Clinical trial NCT02106546: Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Previously Untreated Advanced or Metastatic Squamous Non-Small Cell Lung Cancer
Official title: Randomized, Double-Blind, Multicenter, Phase 3 Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Previously Untreated Advanced or Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Squamous Non-Small Cell Lung Cancer
Keywords: veliparib
carboplatin
paclitaxel
Poly Adenosine diphosphate (ADP)-ribose Polymerase (PARP)
Overall Survival
Advanced
Metastatic
ABT-888
Squamous
Randomized
non-small cell lung cancer
placebo controlled
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2014-04-08
Enrollment: 970
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the safety and efficacy of the addition of veliparib plus carboplatin and paclitaxel versus the addition of placebo plus carboplatin and paclitaxel in adults with advanced or metastatic squamous non-small cell lung cancer (NSCLC).


Eligibility criteria: Inclusion Criteria:

1. Life expectancy \> 12 weeks
2. Subject must have cytologically or histologically confirmed squamous NSCLC.
3. Subject must have advanced or metastatic squamous NSCLC that is not amenable to surgical resection or radiation with curative intent at time of study Screening.
4. Subjects with recurrent squamous NSCLC after surgical treatment that is not amenable to surgical resection or radiation with curative intent are eligible.
5. Subject must have at least 1 unidimensional measurable NSCLC lesion on a computerized tomography (CT) scan as defined by Response Evaluation Criteria In Solid Tumors (RECIST - version 1.1).

Exclusion Criteria:

1. Subject has a known hypersensitivity to paclitaxel or to other drugs formulated with polyethoxylated castor oil (Cremophor).
2. Subject has a known hypersensitivity to platinum compounds.
3. Subject has peripheral neuropathy \>= grade 2.
4. Subject has non-squamous NSCLC, or a known epidermal growth factor receptor (EGFR) mutation of exon 19 deletion or L858R mutation in exon 21, or a known anaplastic lymphoma kinase (ALK) gene rearrangement.
5. Subject has received prior cytotoxic chemotherapy (including definitive chemoradiotherapy) for NSCLC, except for adjuvant or neoadjuvant therapy.

Primary outcomes:
measure: Overall Survival (OS) in current smokers
timeFrame: Up to 3 years from first dose of study drug
Secondary outcomes:
measure: Overall Survival (OS) in all subjects
timeFrame: Up to 3 years from first dose of study drug
measure: Progressive-Free Survival (PFS) in current smokers and in all subjects
timeFrame: Up to 3 years from first dose of study drug
measure: Objective Response Rate (ORR) in current smokers and in all subjects
timeFrame: Up to 3 years from first dose of study drug
Other outcomes:
measure: Change in Quality of Life: European Organisation for Research and Treatment of Cancer Quality of Life Core 30 Question Questionnaire (EORTC-QLQ-C30).
timeFrame: From Screening (prior to dosing) up to 2 years
measure: Change in Quality of Life: European Organisation for Research and Treatment of Cancer Quality of Life Lung Cancer 13 Question Questionnaire (EORTC-LC13).
timeFrame: From Screening (prior to dosing) up to 2 years
measure: Change in Eastern Cooperative Oncology Group (ECOG) Performance Status
timeFrame: From Screening (prior to dosing) up to 2 years
measure: Change in Quality of Life: European Quality of Life-5 Dimensions-5 Levels Questionnaire (EQ-5D-5L)
timeFrame: From Screening (prior to dosing) up to 2 years
measure: Duration of Response
timeFrame: From complete or partial response to disease progression (up to 3 years from randomization).
Locations:
city: Jonesboro
country: United States
facility: Northeast Arkansas Clinical Ch /ID# 128071
state: Arkansas
city: Los Angeles
country: United States
facility: LA Hem-Oncology Med Group /ID# 129178
state: California
city: Aurora
country: United States
facility: VA Eastern Colorado Healthcare System /ID# 128065
state: Colorado
city: Fort Lauderdale
country: United States
facility: Holy Cross Hospital /ID# 128074
state: Florida
city: Gainesville
country: United States
facility: University of Florida - Archer /ID# 126476
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida - Southpoint /ID# 127815
state: Florida
city: Atlanta
country: United States
facility: Winship Cancer Institute of Emory University /ID# 124061
state: Georgia
city: Boise
country: United States
facility: St. Luke's Mountain States Tumor Institute - Boise /ID# 124059
state: Idaho
city: Arlington Heights
country: United States
facility: Illinois Cancer Specialists /ID# 127468
state: Illinois
city: Evanston
country: United States
facility: NorthShore University HealthSystem - Evanston Hospital /ID# 128585
state: Illinois
city: Harvey
country: United States
facility: Ingalls Memorial Hosp /ID# 128360
state: Illinois
city: Zion
country: United States
facility: Midwestern Regional CTC /ID# 126124
state: Illinois
city: Goshen
country: United States
facility: Goshen Center for Cancer Care /ID# 123875
state: Indiana
city: Indianapolis
country: United States
facility: Franciscan St. Francis Health /ID# 126678
state: Indiana
city: Hazard
country: United States
facility: Appalachian Regional Healthcare, Inc (ARH) /ID# 128061
state: Kentucky
city: Detroit
country: United States
facility: Henry Ford Health System /ID# 126500
state: Michigan
city: Lansing
country: United States
facility: Sparrow Regional Cancer Center, Sparrow Health System /ID# 127156
state: Michigan
city: Minneapolis
country: United States
facility: Minnesota Oncology Hematology, PA /ID# 127473
state: Minnesota
city: Lincoln
country: United States
facility: Nebraska Hematology Oncology /ID# 127699
state: Nebraska
city: Lincoln
country: United States
facility: SE Nebraska Hema/Oncology Consultants P.C.d/b/a Southeast Nebraska Cancer Center /ID# 126477
state: Nebraska
city: Las Vegas
country: United States
facility: Comprehensive Cancer Ctrs Neva /ID# 127491
state: Nevada
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center /ID# 128075
state: New Hampshire
city: Hackensack
country: United States
facility: Hackensack Univ Med Ctr /ID# 124057
state: New Jersey
city: Canton
country: United States
facility: Gabrail Cancer Center Research /ID# 127415
state: Ohio
city: Hershey
country: United States
facility: Penn State University and Milton S. Hershey Medical Center /ID# 126676
state: Pennsylvania
city: Germantown
country: United States
facility: The Jones Clinic, PC /ID# 124062
state: Tennessee
city: Austin
country: United States
facility: Texas Oncology - Austin Midtown /ID# 127477
state: Texas
city: Austin
country: United States
facility: Texas Oncology - South Austin /ID# 127476
state: Texas
city: Dallas
country: United States
facility: Parkland Health and Hosp Syste /ID# 128518
state: Texas
city: Dallas
country: United States
facility: Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 128385
state: Texas
city: Dallas
country: United States
facility: UT Southwestern Medical Center /ID# 127876
state: Texas
city: Houston
country: United States
facility: University of Texas MD Anderson Cancer Center /ID# 127946
state: Texas
city: Paris
country: United States
facility: Texas Oncology - Paris /ID# 127484
state: Texas
city: Waco
country: United States
facility: Texas Oncology - Waco /ID# 127459
state: Texas
city: Burlington
country: United States
facility: University of Vermont Medical Center /ID# 128064
state: Vermont
city: Norfolk
country: United States
facility: Virginia Oncology Associates /ID# 127458
state: Virginia
city: Vancouver
country: United States
facility: Northwest Cancer Specialists, P.C. /ID# 127486
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists, P.C. /ID# 127488
state: Washington
city: Wollongong
country: Australia
facility: Southern Medical Day Care Ctr /ID# 125604
state: New South Wales
city: Birtinya
country: Australia
facility: Sunshine Coast University Hosp /ID# 125608
state: Queensland
city: Douglas
country: Australia
facility: The Townsville Hospital /ID# 125609
state: Queensland
city: Bedford Park
country: Australia
facility: Flinders Centre for Innovation /ID# 125605
state: South Australia
city: Woodville
country: Australia
facility: The Queen Elizabeth Hospital /ID# 125607
state: South Australia
city: Geelong
country: Australia
facility: Barwon Health University Hospital Geelong /ID# 125606
state: Victoria
city: Linz
country: Austria
facility: Ordensklinikum Linz GmbH, Elisabethinen /ID# 126183
city: Bobruisk
country: Belarus
facility: Bobruysk Interdistrict Onco. /ID# 128999
city: Brest
country: Belarus
facility: Brest Regional Hospital /ID# 125955
city: Lesnoy
country: Belarus
facility: State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 125815
city: Mogilev
country: Belarus
facility: Mogilev Reg Clin Oncology Dis /ID# 128639
city: Vitebsk
country: Belarus
facility: Vitebsk Reg Clin Onc Disp /ID# 125516
city: Porto Alegre
country: Brazil
facility: Hospital Sao Lucas da PUCRS /ID# 127737
state: Rio Grande Do Sul
city: Itajai
country: Brazil
facility: Clinica de Neoplasias Litoral - Centro de Novos Tratamentos Itajai /ID# 127738
state: Santa Catarina
city: Barretos
country: Brazil
facility: Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 126736
state: Sao Paulo
city: Rio de Janeiro
country: Brazil
facility: Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 127309
city: Rio de Janeiro
country: Brazil
facility: Instituto COI de Educacao e Pesquisa /ID# 127739
city: Sao Paulo
country: Brazil
facility: Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 126737
city: Calgary
country: Canada
facility: University of Calgary /Id# 126326
state: Alberta
city: Edmonton
country: Canada
facility: Cross Cancer Institute /ID# 126154
state: Alberta
city: Hamilton
country: Canada
facility: Juravinski Cancer Clinic /ID# 126153
state: Ontario
city: London
country: Canada
facility: Victoria Hospital /ID# 126669
state: Ontario
city: Ottawa
country: Canada
facility: The Ottawa Hospital /ID# 126522
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Cancer Centre /ID# 126155
state: Ontario
city: Montreal
country: Canada
facility: McGill Univ HC /ID# 130431
state: Quebec
city: Quebec City
country: Canada
facility: CSSS Alphonse-Desjardins, CHAU de Levis /ID# 126149
state: Quebec
city: Québec
country: Canada
facility: Iucpq-Ul /Id# 126524
state: Quebec
city: Zagreb
country: Croatia
facility: Klinika za plucne bolesti Jordanovac /ID# 126537
state: Grad Zagreb
city: Osijek
country: Croatia
facility: Klinicki bolnicki centar Osijek /ID# 132214
state: Osjecko-baranjska Zupanija
city: Pula
country: Croatia
facility: Opca bolnica Pula /ID# 126540
city: Slavonski Brod
country: Croatia
facility: Opca bolnica Dr. Josip Bencevi /ID# 126539
city: Olomouc
country: Czechia
facility: Fakultni Nemocnice Olomouc /ID# 125820
state: Olomoucky Kraj
city: Nová Ves pod Pleší
country: Czechia
facility: Nemocnice Na Plesi s.r.o. /ID# 125817
state: Pribram
city: Kyjov
country: Czechia
facility: Nemocnice Kyjov, prispevkova organizace /ID# 125819
city: Nový Jičín 1
country: Czechia
facility: Nemocnice Novy Jicin /ID# 125818
city: Ostrava
country: Czechia
facility: Vitkovicka nemocnice a. s. /ID# 127023
city: Herlev
country: Denmark
facility: Herlev Hospital /ID# 125995
state: Hovedstaden
city: Odense C
country: Denmark
facility: Odense Universitets Hospital /ID# 125996
state: Syddanmark
city: Alexandria
country: Egypt
facility: University of Alexandria /ID# 128337
city: Cairo
country: Egypt
facility: Naser Institute for Res & Dev /ID# 129263
city: Cairo
country: Egypt
facility: Cairo Uni Hosp Al Kasr El Ainy /ID# 128338
city: Cairo
country: Egypt
facility: Cairo Uni Hosp Al Kasr El Ainy /ID# 128340
city: Tallinn
country: Estonia
facility: North Estonian Medical Centre /ID# 128215
city: Tartu
country: Estonia
facility: Tartu University Hospital /ID# 127735
city: Helsinki
country: Finland
facility: Helsinki Univ Central Hospital /ID# 125897
city: Vaasa
country: Finland
facility: Vaasa Central Hospital /ID# 125896
city: Marseille
country: France
facility: CHU Hopital Nord /ID# 128388
state: Bouches-du-Rhone
city: Pessac CEDEX
country: France
facility: Hopital Haut-Lévêque /ID# 135270
state: Gironde
city: Lille CEDEX
country: France
facility: CHRU Lille - Hôpital Claude Huriez /ID# 126353
state: Hauts-de-France
city: Le Mans CEDEX 9
country: France
facility: Centre Hospitalier Le Mans /ID# 127902
state: Sarthe
city: Creteil
country: France
facility: Centre Hosp Intercommunal de Creteil /ID# 125922
state: Val-de-Marne
city: Brest
country: France
facility: CHRU de Brest - Hopital Morvan /ID# 127903
city: Nice
country: France
facility: Centre Antoine Lacassagne /ID# 126360
city: Rennes
country: France
facility: Hospital Pontchaillou /ID# 126356
city: Toulouse
country: France
facility: Hopital Larrey - CHU de Toulouse /ID# 128394
city: Berlin
country: Germany
facility: Charite-Univ. Berlin, Benjamin-Franklin /ID# 125708
city: Grosshansdorf
country: Germany
facility: Lungen Clinic Grosshansdorf /ID# 126107
city: Kassel
country: Germany
facility: Klinikum Kassel /ID# 127025
city: Löwenstein
country: Germany
facility: Klinik Loewenstein GmbH /ID# 126191
city: Mainz
country: Germany
facility: Univ Johannes Gutenberg /ID# 125603
city: Nea Efkarpia
country: Greece
facility: Papageorgiou General Hospital Thessaloniki /ID# 125876
state: Thessaloniki
city: Athens
country: Greece
facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 125879
city: Athens
country: Greece
facility: Metropolitan Hospital /ID# 125878
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 125877
city: Miskolc
country: Hungary
facility: CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 135234
state: Borsod-Abauj-Zemplen
city: Budapest XII
country: Hungary
facility: Orszagos Koranyi Pulmonologiai Intezet /ID# 126112
state: Budapest
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Központ /ID# 126119
city: Farkasgyepu
country: Hungary
facility: Veszprem Megyei Tudogyogyintez /ID# 126121
city: Gyor
country: Hungary
facility: Petz Aladar Megyei Oktato Korh /ID# 126110
city: Gyula
country: Hungary
facility: Bekes Megyei Pandy Kalman Korhaz /ID# 126117
city: Kékesteto
country: Hungary
facility: Matrahaza Gyogyintezet /ID# 126109
city: Szekesfehervar
country: Hungary
facility: Fejer Megyei Szent Gyorgy Korh /ID# 126118
city: Szolnok
country: Hungary
facility: Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz /ID# 126120
city: Torokbalint
country: Hungary
facility: Tudogyogyintezet Toeroekbalint /ID# 126111
city: Dublin 8
country: Ireland
facility: St. James's Hospital /ID# 126177
state: Dublin
city: Cork
country: Ireland
facility: Cork University Hospital /ID# 126176
city: Dublin
country: Ireland
facility: Beaumont Hospital /ID# 126218
city: Limerick
country: Ireland
facility: University Hospital Limerick /ID# 126175
city: Waterford
country: Ireland
facility: University Hospital Waterford /ID# 126178
city: Be'er Ya'akov
country: Israel
facility: Assaf Harofeh Medical Center /ID# 127076
city: Jerusalem
country: Israel
facility: Hadassah University Hospital /ID# 127077
city: Kfar Saba
country: Israel
facility: Meir Medical Center /ID# 127078
city: Ramat Gan
country: Israel
facility: Sheba Medical Center /ID# 127079
city: Avellino
country: Italy
facility: AO San Giuseppe Moscati /ID# 125701
city: Milan
country: Italy
facility: Istituto Europeo di Oncologia /ID# 125702
city: Monza
country: Italy
facility: Azienda Ospedaliera San Gerardo di Monza _ Oncologia Medica /ID# 125704
city: Orbassano
country: Italy
facility: A.O.U. San Luigi Gonzaga /ID# 125700
city: Parma
country: Italy
facility: Azienda Ospedaliero Uni Parma /ID# 125703
city: Perugia
country: Italy
facility: Azienda Ospedaliera-Universitaria di Perugia-Divisione di Oncologia Medica. /ID# 125699
city: Viagrande
country: Italy
facility: Istituto Oncologico del Medite /ID# 132844
city: Riga
country: Latvia
facility: Riga East Clinical Univ Hosp /ID# 125597
city: Riga
country: Latvia
facility: P. Stradins Clinical Univ Hosp /ID# 126322
city: Kovno
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 127176
state: Kaunas
city: Vilnius
country: Lithuania
facility: National Cancer Institute /ID# 126323
city: Chihuahua
country: Mexico
facility: Centro Estatal de Cancerologia /ID# 127583
city: San Luis Potosí
country: Mexico
facility: Hospital Angeles Centro Medico /ID# 127620
city: Santiago de Querétaro
country: Mexico
facility: Cancerologia de Queretaro S.C. /ID# 125920
city: Amsterdam
country: Netherlands
facility: Vrije Universiteit Medisch Centrum /ID# 125578
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis /ID# 126466
city: Eindhoven
country: Netherlands
facility: Catharina Ziekenhuis /ID# 125577
city: Harderwijk
country: Netherlands
facility: Ziekenhuis St. Jansdal /ID# 125576
city: Heerlen
country: Netherlands
facility: Atrium-Orbis Zuyderland Medisch Centrum /ID# 125710
city: S Hertogenbosch
country: Netherlands
facility: Jeroen Bosch Ziekenhuis /ID# 125709
city: Zwolle
country: Netherlands
facility: Isala /ID# 125579
city: Wellington
country: New Zealand
facility: Wellington Hospital (Capital and Coast District Health Board) /ID# 125755
city: Bergen
country: Norway
facility: Haukeland University Hospital /ID# 126338
state: Hordaland
city: Bodø
country: Norway
facility: Nordland Hospital /ID# 126337
city: Kristiansand
country: Norway
facility: Sorlandet Sykehus HF /ID# 126341
city: Oslo
country: Norway
facility: Oslo Universitetssykehus, Radiumhospitalet /ID# 126335
city: Stavanger
country: Norway
facility: Stavanger University Hospital /ID# 126336
city: Tonsberg
country: Norway
facility: Sykehuset i Vestfold HF /ID# 126340
city: Rzeszów
country: Poland
facility: Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 126548
state: Podkarpackie
city: Gdynia
country: Poland
facility: Szpital Morski im. PCK /ID# 126547
city: Warsaw
country: Poland
facility: NZOZ Magodent Ctr. Med. Ostro /ID# 126545
city: Wieliszew
country: Poland
facility: Mazowiecki Szpital Onkologiczn /ID# 126546
city: Guimaraes
country: Portugal
facility: Hospital Senhora da Oliveira de Guimaraes, EPE /ID# 126761
state: Braga
city: Braga
country: Portugal
facility: CCA Braga - Hospital de Braga /ID# 125837
city: Coimbra
country: Portugal
facility: Ctr Hosp Univ Coimbra, EPE /ID# 125838
city: Lisbon
country: Portugal
facility: Hospital Pulido Valente /ID# 125835
city: Porto
country: Portugal
facility: IPO Porto FG, EPE /ID# 125836
city: Porto
country: Portugal
facility: Centro Hospitalar de Sao Joao, EPE /ID# 125875
city: San Juan
country: Puerto Rico
facility: VA Caribbean Healthcare System /ID# 124562
city: Moscow
country: Russian Federation
facility: Federal State Budgetary Scientific Institution N.N. Blokhin Russian Cancer Resea /ID# 128458
state: Moskva
city: Ekaterinburg
country: Russian Federation
facility: Sverdlovsk Regional Oncology Center Dispensary /ID# 128457
state: Sverdlovskaya Oblast
city: Volgograd
country: Russian Federation
facility: Volgograd Regional Clinical Oncology Dispensary /ID# 126350
state: Volgogradskaya Oblast
city: Belgorod
country: Russian Federation
facility: Belgorod Oncology Dispensary /ID# 129899
city: Irkutsk
country: Russian Federation
facility: State Budgetary Healthcare Institution"Irkutsk Regional Oncology Center /ID# 128460
city: Murmansk
country: Russian Federation
facility: State Regional Budgetary Healthcare Institution " Murmansk Regional Oncology Dis /ID# 128461
city: Orenburg
country: Russian Federation
facility: Orenburg Regional Clinical Onc /ID# 137474
city: Saransk
country: Russian Federation
facility: Ogarev Mordovia State Univ /ID# 127595
city: Smolensk
country: Russian Federation
facility: Smolensk Regional Onc Clin Dis /ID# 127144
city: Tomsk
country: Russian Federation
facility: Cancer Research Institute Siberian Branch of the Russian Academy of Medical Scie /ID# 127143
city: Belgrade
country: Serbia
facility: Clinical Center Serbia /ID# 128738
state: Beograd
city: NIS
country: Serbia
facility: Clinical Center of Nis /ID# 128735
state: Nisavski Okrug
city: Belgrade
country: Serbia
facility: Institute for Oncology and Rad /ID# 128721
city: Belgrade
country: Serbia
facility: University Hospital Bezanijska /ID# 128761
city: Sremska Kamenica
country: Serbia
facility: Institute For Pulmonary Diseas /ID# 128737
city: Bratislava
country: Slovakia
facility: Univerzitna Nemocnica Bratislava /ID# 126342
city: Pieštany
country: Slovakia
facility: MEDEON, s.r.o. /ID# 128517
city: Port Elizabeth
country: South Africa
facility: GVI Oncology /ID# 126102
state: Eastern Cape
city: Johannesburg
country: South Africa
facility: Wits Clinical Research Site /ID# 126101
state: Gauteng
city: Johannesburg
country: South Africa
facility: Sandton Oncology Centre /ID# 126097
state: Gauteng
city: Pretoria
country: South Africa
facility: University of Pretoria /ID# 127297
state: Gauteng
city: Pretoria
country: South Africa
facility: Dr Albert, Bouwer and Jordaan Incorporated /ID# 126098
state: Gauteng
city: Pretoria
country: South Africa
facility: Mary Potter Oncology Centre /ID# 126099
state: Gauteng
city: Durban
country: South Africa
facility: The Oncology Centre /ID# 126096
state: Kwazulu-Natal
city: Cape Town
country: South Africa
facility: Netcare Oncology Intervent Ctr /ID# 126100
state: Western Cape
city: George
country: South Africa
facility: Cancercare Outeniqua Oncology Unit /ID# 126103
state: Western Cape
city: L'Hospitalet de Llobregat
country: Spain
facility: Hospital Duran i Reynals /ID# 125161
state: Barcelona
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro Majadahonda /ID# 125160
state: Madrid
city: Barcelona
country: Spain
facility: Hospital Universitario Vall d'Hebron /ID# 125159
city: Madrid
country: Spain
facility: Hospital Universitario HM Sanchinarro /ID# 125162
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio /ID# 125207
city: Valencia
country: Spain
facility: Fundacion Instituto Valenciano Oncologia IVO /ID# 125205
city: Gavle
country: Sweden
facility: Gavle Sjukhus /ID# 126444
city: Goteborg
country: Sweden
facility: Sahlgrenska University Hosp /ID# 129997
city: Linkoping
country: Sweden
facility: University Hospital Linkoping /ID# 126443
city: Solna
country: Sweden
facility: Karolinska Univ Sjukhuset /ID# 126445
city: St. Gallen
country: Switzerland
facility: Kantonsspital St. Gallen /ID# 126349
state: Sankt Gallen
city: Aarau
country: Switzerland
facility: Hirslanden Medical Center /ID# 128216
city: Bern
country: Switzerland
facility: Inselspital, Universitaetsklinik /ID# 126347
city: Thun
country: Switzerland
facility: Spital STS AG /ID# 126348
city: Antalya
country: Turkey
facility: Akdeniz University Medical Fac /ID# 126997
city: Istanbul
country: Turkey
facility: Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 126186
city: Istanbul
country: Turkey
facility: Marmara University Medical Fac /ID# 126187
city: Izmir
country: Turkey
facility: Ege University Medical Faculty /ID# 126189
city: Izmir
country: Turkey
facility: Dr. Suat Seren Gogus Has /ID# 126190
city: Kharkiv
country: Ukraine
facility: Communal non-profit enterprise Regional Center of Oncology /ID# 128221
state: Kharkivska Oblast
city: Cherkasy
country: Ukraine
facility: Cherkassy Regional Onc Ctr /ID# 128222
city: Chernivtsi
country: Ukraine
facility: Regional Municipal Non-Profit Enterprise Bukovynian Clinical Oncology Center /ID# 128220
city: Dnipro
country: Ukraine
facility: Municipal Non-Profit Enterprise City Clinical Hospital No.4 of Dnipro City Counc /ID# 128217
city: Lviv
country: Ukraine
facility: Lviv Oncological Regional Therapeutical and Diagnostic Centre /ID# 128218
city: Poltava
country: Ukraine
facility: Poltava Regional Clinical Oncology Centre of Poltava Regional Council /ID# 128223
city: Sumy
country: Ukraine
facility: Municipal Non-Profit Enterprise of Sumy Regional Council Sumy Regional Clinical /ID# 128219
city: Cheltenham
country: United Kingdom
facility: Cheltenham General Hospital /ID# 125692
state: Gloucestershire
city: London
country: United Kingdom
facility: Guy's and St Thomas' NHS Found /ID# 125694
state: London, City Of
city: Norwich
country: United Kingdom
facility: Norfolk and Norwich Univ Hosp /ID# 125697
state: Norfolk
city: Bangor
country: United Kingdom
facility: Betsi Cadwaladr Univ Health Bo /ID# 127177
city: Barnstaple
country: United Kingdom
facility: North Devon District Hospital /ID# 125689
city: Bournemouth
country: United Kingdom
facility: The Royal Bournemouth Hospital /ID# 125690
city: Canterbury
country: United Kingdom
facility: East Kent Hosp Univ NHS Trust /ID# 125698
city: Glasgow
country: United Kingdom
facility: Gartnavel General Hospital /ID# 126233
city: Great Yarmouth
country: United Kingdom
facility: James Paget University Hosp /ID# 125696
city: London
country: United Kingdom
facility: Charing Cross Hospital /ID# 125688
city: Maidstone
country: United Kingdom
facility: Maidstone Hospital /ID# 125693
city: Newcastle Upon Tyne
country: United Kingdom
facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 129228
city: Wirral
country: United Kingdom
facility: The Clatterbridge Cancer Ctr /ID# 125695
Study officials:
affiliation: AbbVie
name: AbbVie Inc.
role: STUDY_DIRECTOR
References:
citation: Ramalingam SS, Novello S, Guclu SZ, Bentsion D, Zvirbule Z, Szilasi M, Bernabe R, Syrigos K, Byers LA, Clingan P, Bar J, Vokes EE, Govindan R, Dunbar M, Ansell P, He L, Huang X, Sehgal V, Glasgow J, Bach BA, Mazieres J. Veliparib in Combination With Platinum-Based Chemotherapy for First-Line Treatment of Advanced Squamous Cell Lung Cancer: A Randomized, Multicenter Phase III Study. J Clin Oncol. 2021 Nov 10;39(32):3633-3644. doi: 10.1200/JCO.20.03318. Epub 2021 Aug 26.