Clinical trial NCT03286387: Contextual Associations During Episodic Recall of Everyday or Virtual Reality
Official title: Contextual Associations During Episodic Recall of Everyday or Virtual Reality
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Volunteers
Keywords: Memory
naturalistic
context
fMRI
Attention
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2017-09-18
Enrollment: 95
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The project is dedicated to development of new paradigms to investigate memory and attention in the rich and realistic environments. The investigator will use modern interactive digital technologies for encoding complex episodes either using mobile phone technology in everyday life or using a virtual reality life-like simulation.

He aims to characterize the role of the medial temporal lobe and prefrontal cortex during recall of naturalistic episodic experiences, using functional neuroimaging (fMRI) in healthy participants. The secondary aim is assess how the allocation of attention during memory encoding contribute to mechanisms of the subsequent recall. He will achieve this by monitoring gaze direction during encoding and by analyzing the retrieval data as a function of the elements that participants attended / fixated during encoding.

The protocol will involve, first, behavioral testing of memory performance with encoding in the real-life or in virtual reality, followed by the main hypothesis testing phase when fMRI will be used to measure brain activity during retrieval.


Eligibility criteria: Inclusion Criteria:

* Possession a Smartphone compatible with GPS 3-rd generation and exploitation system Android 4.2 with user-activated geolocation (for mobile phone studies).
* Able to navigate in virtual reality with a help of the keyboard (for virtual reality studies).
* Not using glasses.
* All subjects will give their written consent for participation in the study.
* They will be right-handed
* They will have French social coverage.

Exclusion Criteria:

* Previous neurologic or psychiatric disease.
* Cognitive deficits restricting understanding of the tasks.
* Pregnant or breath-feeding women.
* Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights or liberty.
* Subjects currently participating in other study.

Additional exclusion criteria for an fMRI recording

* Neurologic, cardiac electrostimulation or defibrillator.
* Cardiac prostheses
* Intracranial clips or clamps
* Cerebrospinal fluid disorders
* Metal particles in the eyes
* Metal dental or articular prostheses
* Diffusion pomp or other infusion system
* Claustrophobia
* Head tattoo , makeup, hair gel

Primary outcomes:
measure: BOLD cerebral response to contextual recall in medial temporal lobe
timeFrame: up to 1 week after the end of the encoding session
measure: BOLD cerebral response to contextual recall in prefrontal cortex
timeFrame: up to 1 week after the end of the encoding session
Secondary outcomes:
measure: Pattern of gaze fixation during episodic encoding and cerebral activity during recall
timeFrame: up to 1 week after the end of the encoding session
Other outcomes:
Locations:
city: Bron
country: France
facility: U1028 INSERM - CNRS UMR 5292 Equipe ImpAct
Study officials:
affiliation: INSERM U1028 - Impact - CRNL
name: Emiliano MACALUSO, PhD
role: PRINCIPAL_INVESTIGATOR
References: