Clinical trial NCT03895554: Quantification of Myocardial Blood Flow by Positron Emission Tomography in Healthy Volunteers
Official title: Quantification of Myocardial Blood Flow by Positron Emission Tomography in Healthy Volunteers
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Normal Healthy Volunteers Without Chronic Medical Conditions
Lead sponsor: Ochsner Health System
Sponsor class: OTHER
First posted: 2019-03-29
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Volunteers will be selected from the local community.

Brief summary: To establish quantitative values of myocardial blood flow (MBF) in normal, healthy volunteers .

Detailed description: We seek to establish quantitative values of myocardial blood flow in 20 normal, healthy volunteers using our existing 2D PET camera (Positron Attrius) and invasively validated software package (HeartSee) in order to 1) establish institutional values for which clinical patients can be compared to and 2) add to the collective data of the scientific community. Values to be measured will be resting myocardial blood flow (MBF), stress MBF and coronary flow reserve.

Eligibility criteria: Inclusion Criteria:

* Adults ≥18 and \<40 years old
* Participants must be able to give informed consent.
* Ability to abstain from caffeine for 48 hours

Exclusion Criteria:

* Any chronic cardiac disease or condition (e.g. hypertension, hyperlipidemia)
* Any chronic systemic disease or condition (e.g. diabetes, systemic lupus, rheumatoid arthritis)
* Tobacco use
* Family history in a first degree relative with clinical coronary artery disease (history of myocardial infarctio, percutaneous intervention or coronary artery bypass grafting) in men \<55 years old or women \<65 years old
* Severe claustrophobia
* Positive urine pregnancy test
* Inability to give informed consent

Primary outcomes:
measure: Absolute myocardial blood flow at rest and stress in cc/min/g
timeFrame: measured at the time of the cardiac PET stress scan
Secondary outcomes:
Other outcomes:
Locations:
city: New Orleans
country: United States
facility: Ochsner
state: Louisiana
Study officials:
References:
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