Clinical trial NCT04388345: SILENT SINUS SYNDROME (First Case Report, Saudi Arabia With Recommendation)
Official title: SILENT SINUS SYNDROME (First Case Report, Saudi Arabia With Recommendation)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: SILENT SINUS SYNDROME
Keywords: Case report
Silent sinus syndrome
SSS
CT
MRI
Functional endoscopic sinus surgery
Lead sponsor: King Saud University
Sponsor class: OTHER
First posted: 2020-05-14
Enrollment: 1
Sex: FEMALE
Minimum age (years): 37
Maximum age (years): 37
Standard ages: ADULT
Observational model: CASE_CROSSOVER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: community sample

Brief summary: Silent sinus syndrome is a rare disorder that presents a diagnostic challenge, most of the patients with this syndrome present with ophthalmological complaints without any nasal sinus symptoms, and it has a painless course and slow development. A case report of a 37-years-old-female who was complaining of severe throbbing pain since 2009, is presented here where the diagnosis of SSS was obtained in 2018, this delay in diagnosing the situation had affected the patient lifestyle tremendously.

Detailed description: Silent sinus syndrome is a rare disorder that presents a diagnostic challenge, most of the patients with this syndrome present with ophthalmological complaints without any nasal sinus symptoms, and it has a painless course and slow development. The syndrome can be diagnosed clinically and confirmed radiologically, and CT imaging is considered the gold standard for its diagnosis. The classical radiographic findings are opacification and collapse of the sinus walls. Functional endoscopic sinus surgery (FESS) is the standard gold treatment of choice to arrest the progression of the disease.

A case report of a 37-years-old-female who was complaining of severe throbbing pain since 2009, is presented here where the diagnosis of SSS was obtained in 2018, this delay in diagnosing the situation had affected the patient lifestyle tremendously.

Accordingly, knowledge of the signs and features of SSS can result in an accurate diagnosis. Suspected cases of silent sinus syndrome require prompt ear, nose, and throat referral for consideration of definitive diagnosis and surgical management. Nasal endoscopy and clinical evaluation are also essential for the diagnosis. Our recommendation is to consider SSS as a differential diagnosis for patients with spontaneous enophthalmos and hypoglobus, even in the absence of maxillary sinus opacification. Moreover, encourage all the specialists in the medical and the dental field to communicate well together in cases like this.

Eligibility criteria: Inclusion Criteria:

signs or symptoms in the eyes. signs in the Sinus that seen by X-ray.

Exclusion Criteria:

Children ( \<7 years old)

Primary outcomes:
measure: Knowledge of the signs and features of Silent Sinus Syndeome will result in accurate diagnosis by A computerized tomography (CT) scan.
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Riyadh
country: Saudi Arabia
facility: King Saud University
Study officials:
References:
citation: Cobb AR, Murthy R, Cousin GC, El-Rasheed A, Toma A, Uddin J, Manisali M. Silent sinus syndrome. Br J Oral Maxillofac Surg. 2012 Sep;50(6):e81-5. doi: 10.1016/j.bjoms.2011.10.001. Epub 2011 Nov 1.
citation: Bossolesi P, Autelitano L, Brusati R, Castelnuovo P. The silent sinus syndrome: diagnosis and surgical treatment. Rhinology. 2008 Dec;46(4):308-16.
citation: Guillen DE, Pinargote PM, Guarderas JC. The silent sinus syndrome: protean manifestations of a rare upper respiratory disorder revisited. Clin Mol Allergy. 2013 Dec 9;11(1):5. doi: 10.1186/1476-7961-11-5.
citation: Hourany R, Aygun N, Della Santina CC, Zinreich SJ. Silent sinus syndrome: an acquired condition. AJNR Am J Neuroradiol. 2005 Oct;26(9):2390-2.
citation: Soparkar CN, Patrinely JR, Cuaycong MJ, Dailey RA, Kersten RC, Rubin PA, Linberg JV, Howard GR, Donovan DT, Matoba AY, et al. The silent sinus syndrome. A cause of spontaneous enophthalmos. Ophthalmology. 1994 Apr;101(4):772-8. doi: 10.1016/s0161-6420(94)31267-x.
citation: Vahdani K, Rose GE. Bilateral Silent Sinus (Imploding Antrum) Syndrome. Ophthalmic Plast Reconstr Surg. 2019 May/Jun;35(3):e67-e69. doi: 10.1097/IOP.0000000000001350.
citation: Babar-Craig H, Kayhanian H, De Silva DJ, Rose GE, Lund VJ. Spontaneous silent sinus syndrome (imploding antrum syndrome): case series of 16 patients. Rhinology. 2011 Aug;49(3):315-7. doi: 10.4193/Rhino10.103.
citation: Tribich S, Mahoney CJ, Davies NW. Silent sinus syndrome: an unusual case of facial numbness. Pract Neurol. 2018 Dec;18(6):494-496. doi: 10.1136/practneurol-2017-001807. Epub 2018 Jul 20.
citation: Numa WA, Desai U, Gold DR, Heher KL, Annino DJ. Silent sinus syndrome: a case presentation and comprehensive review of all 84 reported cases. Ann Otol Rhinol Laryngol. 2005 Sep;114(9):688-94. doi: 10.1177/000348940511400906.
citation: Suh JD, Ramakrishnan V, Lee JY, Chiu AG. Bilateral silent sinus syndrome. Ear Nose Throat J. 2012 Dec;91(12):E19-21. doi: 10.1177/014556131209101217.