louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05288322: Mostafa Maged Maneuveur to Prevent and Control Post-partum Haemorrhage During Normal Vaginal Delivery
Official title: The Effectiveness of Mostafa Maged Maneuveur to Prevent and Control Post-partum Haemorrhage During Normal Vaginal Delivery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post Partum Hemorrhage
Keywords: Mostafa Maged maneuver
Atony
normal delivery
postpartum bleeding
Lead sponsor: Fayoum University
Sponsor class: OTHER
First posted: 2022-03-21
Enrollment: 150
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: PPH is commonly defined as blood loss exceeding 1000 milliliters after vaginal birth or cesarean section.1 PPH is often classified as primary/immediate/early (occurring within 24 hours of birth) or secondary/delayed/late (occurring from more than 24 hours postbirth to up to 12 weeks postpartum)..

Atonic post-partum haemorrhage is one of the most challenging complications of normal delivery process . There are many maneuveurs applied to the atonic uterus for controlling the blood loss and conserving the uterus from hysterectomy process . There are pharmacological and surgical methods to control the bleeding . In this study , Mostafa Maged technique is to prevent and control post-partum bleeding during vaginal delivery . It is so simple and not-costly method .

Detailed description: In this study , Mostafa Maged technique to prevent and control post-partum bleeding during vaginal delivery . It is so simple and not-costly method . Mostafa Maged maneuveur has been applied to those all female patients to prevent or control post-partum bleeding in normal delivery . Mostafa Maged technique is applied by :- (Description of the Mostafa Maged technique) :-

1. First , placing the right hand to the posterior fornix of vaginal canal trying to cuddle the lower part of uterus compressing the anterior and posterior walls of the uterus .
2. Second , placing the left hand over the fundus of the uterus and the posterior wall of uterus from the abdominal part of the pregnant mother ( the side of the abdominal skin ) .
3. Third , by the two hands , trying to grasp the whole uterus by the two hands abdominally and vaginally against the symphysis pubis as if the uterus is cuddling the symphysis pubis bone and in this way , getting the anterior and posterior walls of the uterus against each other compressed is achieved and reducing the intra-cavitary space so prevention of the expansion of the uterus is applied .

Eligibility criteria: Inclusion Criteria:

* pregnant females Inclusion criteria :-

  1. All pregnant patients
  2. Age is between (18) to (40) years old

Exclusion Criteria:

1. Smokers
2. Morbid obese
3. Medical history of blood diseases and collagen diseases

Primary outcomes:
measure: post-partum bleeding
timeFrame: six hours post-delivery
Secondary outcomes:
Other outcomes:
Locations:
city: Fayoum
country: Egypt
facility: Fayoum general hospital and Fayoum university
Study officials:
References:
Clinical trial NCT00363922: Rehabilitation After Coronary Bypass Grafting. Comparison of Different Types of Rehabilitation Programs
Official title: Rehabilitation After Coronary Bypass Grafting: Home Based Rehabilitation Versus Rehabilitation in Institution and Rehabilitation in Institution Versus Out-patient Rehabilitation at the Hospital
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Coronary Artery Disease
Keywords: Coronary Artery Bypass [E04.100.376.719.332]
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
Collaborators: name: Stiftelsen Helse og Rehabilitering
First posted: 2006-08-15
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare different types of rehabilitation after coronary bypass surgery. The investigators wish to compare rehabilitation in an institution for four weeks with a home based rehabilitation. They also wish to compare rehabilitation in an institution for four weeks with a rehabilitation program were the patients live at home but visit the hospital twice a week for twelve week. The investigators will measure the patients' physical capacity by measuring their maximal oxygen consumption. The investigators will also analyze their blood and their endothelian function (how well their arteries dilate).


Eligibility criteria: Inclusion Criteria:

* Coronary artery bypass

Exclusion Criteria:

* Significant lung disease
* Drug abuse
* Pregnancy
* Major physical impairment

Primary outcomes:
measure: Maximal oxygen consumption
timeFrame: At baseline and after 6 months
Secondary outcomes:
measure: Blood analyses (different markers for cardiovascular risk and endothelian function)
timeFrame: At baseline and after 6 months
measure: Endothelian function (flow mediated dilatation)
timeFrame: At baseline and after 6 months
measure: Quality of life (SF36 and MacNew)
timeFrame: At baseline and after 6 months
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Norwegian University of Science and Technology
Study officials:
affiliation: National Taiwan Normal University
name: Trine T. Moholdt, cand.polit
role: PRINCIPAL_INVESTIGATOR
References:
citation: Moholdt T, Bekken Vold M, Grimsmo J, Slordahl SA, Wisloff U. Home-based aerobic interval training improves peak oxygen uptake equal to residential cardiac rehabilitation: a randomized, controlled trial. PLoS One. 2012;7(7):e41199. doi: 10.1371/journal.pone.0041199. Epub 2012 Jul 18.
Clinical trial NCT02220322: Age-related Cognitive Change of Femur
Official title: Age-related Cognitive Change of Femur
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Osteoporosis
Keywords: cortical thickness
age
Lead sponsor: Tomidahama Hospital
Sponsor class: OTHER
First posted: 2014-08-19
Enrollment: 1000
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Osteoporosis or osteopenia patients

Brief summary: Age-related change of femur is not well-known. The investigators investigated the longitudinal changes of femur.

Detailed description: Recently, bisphosphonate-related atypical fracture of femur (AFF) is paid attention in clinicians. Almost all AFFs were occurred in thicker cortical thickness. But age-related change of femur is not well-known.

The main objective of this study is to reveal the age-related change of femur.

Eligibility criteria: Inclusion Criteria:

* Osteoporosis or osteopenia patients who presented to our hospital

Exclusion Criteria:

* Patients without osteoporosis or osteopenia

Primary outcomes:
measure: Age-related change of femur
timeFrame: Up to 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Yokkaichi
country: Japan
facility: Tomidahama Hospital
state: Mie
Study officials:
affiliation: Tomidahama Hospital
name: Rui Niimi, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01076322: A Study to Evaluate the Efficacy and Safety of Meptin® Swinghaler® and Ventolin® MDI in Stable Asthma Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Asthma
Lead sponsor: Taiwan Otsuka Pharm. Co., Ltd
Sponsor class: INDUSTRY
First posted: 2010-02-26
Enrollment: 17
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This is an open-label, randomized, cross-over, active-controlled study to evaluate the efficacy and safety effects using Meptin® Swinghaler and Ventolin® MDI in stable asthma patients.


Eligibility criteria: Inclusion Criteria:

1. Male or females outpatients aged ≥ 16 years old with stable mild to moderate persistent asthma; Stability was assessed the patient remained in the same severity class (mild, moderate) and had no acute exacerbations by investigator judgment during the past 14 days;
2. Pulmonary function test:

   * Improvement ≥12% reversibility in FEV1 or FVC following administration of an inhaled β2-agonist before the study or ;
   * Positive result of Broncho-provocation test (PC20 ≤ 32 mg/ml) before the study.
3. Baseline forced expiratory volume in one second 60% ≤(FEV1)≤ 90% of predicted value on entry of the study;

Exclusion Criteria:

1. Hypersensitivity to β2-agonist or lactose;
2. Hospitalization due to asthma during the previous 3months;
3. Respiratory tract infection requiring treatment with antibiotics in the previous 4 weeks;
4. Oral or systemic corticosteroids in the previous 4weeks;
5. Inadequately controlled hyperthyroidism;
6. Severe hepatic or renal or cardiovascular disease as judged by the investigator;
7. Patients receive an investigational drug within 30 days prior to admission to the study;
8. Patients with significant alcohol, drug or medication abuse as judged by the investigator;
9. Females who are pregnant or breast-feeding; (exception: Females of child-bearing age might be included, if in the opinion of the investigator, they are using adequate contraceptive precautions).

Primary outcomes:
measure: The change in Forced Expiratory Volume in 1 second (FEV1) value.
timeFrame: 2 days
Secondary outcomes:
measure: The change in sGaw
timeFrame: 2 days
measure: The changes in IOS parameters (R, X and RF)
timeFrame: 2 days
measure: The change in Peak Expiratory Flow Rate (PEFR)
timeFrame: 2 days
measure: The change in Forced Vital Capacity (FVC)
timeFrame: 2 days
measure: The change in Oxygen Saturation (SpO2)
timeFrame: 2 days
measure: The change in Borg scale
timeFrame: 2 days
measure: Device acceptance
timeFrame: 2 days
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: Ping-Hung Kuo, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01995422: Effect of Physical Activity on Depressive Symptoms With a 5 Month Follow-up
Official title: Effects of Physical Activity Program on the Emotional and Cognitive Dynamics in Major Depressive Disorder Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Major Depressive Disorder
Keywords: Major depressive disorder
Follow-up study
Ecological momentary assessment
Physical activity
Depression
Self-esteem
Anxiety
Rumination
Quality of life
Lead sponsor: Laboratory Motricité, Interactions, Performance
Sponsor class: OTHER
Collaborators: name: Nantes University Hospital
First posted: 2013-11-26
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The main objective of this study is to evaluate the effect of a 12 weeks adapted physical activity program (active walking) on depression by analyzing the dynamics of emotional and cognitive functioning. The secondary objectives are to test the effects of a physical activity on functional performance and to highlight psychological mechanisms.

Detailed description: Primary outcomes:

Self evaluations concerning global self-esteem, a perception of competence and satisfaction in the physical self and four sub-domains that are perceived physical endurance, perceived competence in sports, perceived physical force and perceived physical appearance, are performed.

Assessment of depressive symptomatology is also realised including momentary levels of depression, anxiety, rumination, efficacy of coping strategies and quality of life.

Secondary outcomes:

Assessment of postural control

Eligibility criteria: Inclusion Criteria:

* Speaking French
* Aged between 18 and 65 years
* Diagnosed with current major depressive disorder
* BDI II score ≥ 12
* IPAQ score \<600

Exclusion Criteria:

* Alcohol or substance(s) dependence(s)
* Psychotic disorders
* Anti-social personality
* Pregnant or nursing women
* Physical inability to perform active walking

Primary outcomes:
measure: Effect of physical activity on depression
timeFrame: Five months
Secondary outcomes:
measure: Distraction, self-efficacy and social support scores on 7-point Likert scales and balance on force platform
timeFrame: Five months
Other outcomes:
Locations:
city: Nantes
country: France
facility: University of Nantes
state: Pays de la Loire
Study officials:
affiliation: Laboratory MIP
name: Marina Bourbousson, PhD
role: STUDY_DIRECTOR
References:
citation: Deschamps T, Thomas-Ollivier V, Sauvaget A, Bulteau S, Fortes-Bourbousson M, Vachon H. Balance characteristics in patients with major depression after a two-month walking exercise program: A pilot study. Gait Posture. 2015 Oct;42(4):590-3. doi: 10.1016/j.gaitpost.2015.07.057. Epub 2015 Jul 31.
Clinical trial NCT03279822: Association Analysis for Chronic Diseases Based on Resident Health Records by Using Big Data Methods
Official title: Association Analysis for Chronic Diseases Based on Resident Health Records in China by Using Big Data Methods
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Disease
Lead sponsor: Shanghai Tongji Hospital, Tongji University School of Medicine
Sponsor class: OTHER
Collaborators: name: Huashan Hospital
First posted: 2017-09-12
Enrollment: 10000000
Sex: ALL
Minimum age (years): 20
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The investigators collect data regarding residents health records from rural and urban in China. This study needs more than 10 million resident records from 2010.

Brief summary: This is an observational study to analysis the association factors for common diseases, including chronic obstructive pulmonary disease, coronary artery disease, hypertension, diabetes etc, based on resident healthcare records. More than 10 million resident healthcare records should be collected for the associations study by using big data methods.


Eligibility criteria: Inclusion Criteria:

* Survey Chinese residents aged 20 - 100 years, were included in this study.

Exclusion Criteria:

* Serious hepatic or renal dysfunctions.

Primary outcomes:
measure: regular diagnosis and medical history of common diseases
timeFrame: an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Huasha Hospital
state: Shanghai
Study officials:
References:
citation: Liu J, Xu F, Mohammadtursun N, Lv Y, Tang Z, Dong J. The Analysis of Constitutions of Traditional Chinese Medicine in Relation to Cerebral Infarction in a Chinese Sample. J Altern Complement Med. 2018 May;24(5):458-462. doi: 10.1089/acm.2017.0027. Epub 2017 Aug 18.
citation: Li X, Lei T, Tang Z, Dong J. Analyzing the association between fish consumption and osteoporosis in a sample of Chinese men. J Health Popul Nutr. 2017 Apr 19;36(1):13. doi: 10.1186/s41043-017-0088-y.
Clinical trial NCT01610622: Estimation of Cardiac Output in Neonatal ICU Using an Ultrasound Dilution Technique
Official title: Estimation of Cardiac Output in Neonatal ICU Using an Ultrasound Dilution Technique
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neonatal Intensive Care
Keywords: Cardiac Output
Blood volumes
Neonates
Lead sponsor: Transonic Systems Inc.
Sponsor class: INDUSTRY
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2012-06-04
Enrollment: 7
Sex: ALL
Maximum age (years): 1
Standard ages: CHILD
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients from Neonatal Intensive Care Unit

Brief summary: Presently there is no apparatus, clinically available, for routine determination of cardiac output (CO) in children. The goal of this research is to develop new technology that will help determine CO in neonates.


Eligibility criteria: Inclusion Criteria:

* All neonatal patients cared for in our ICU with umbilical venous and arterial catheters simultaneously in place for their care, will be eligible.

Exclusion Criteria:

* Patients would be excluded if the family/guardian denied permission or if the attending physician felt the patient was not stable.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Syracuse
country: United States
facility: Crouse Hospital
state: New York
Study officials:
affiliation: Crouse Hospital
name: Bonnie Marr, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00012922: Low Literacy Intervention for Colorectal Cancer Screening
Official title: Low Literacy Intervention for Colorectal Cancer Screening
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colorectal Cancer
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2001-03-16
Enrollment: 2400
Sex: MALE
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: Of 17 performance measures of hospital quality regularly reported for the Veterans Administration (VA) health care system, rates of colorectal cancer screening are the lowest.

Detailed description: Background:

Of 17 performance measures of hospital quality regularly reported for the Veterans Administration (VA) health care system, rates of colorectal cancer screening are the lowest.

Objectives:

The objectives of this study were to 1) test whether a health care provider-directed intervention increased colorectal cancer screening rates in an urban VA medical center and 2) evaluate the cost-effectiveness of the intervention.

Methods:

The study was a randomized controlled trial, conducted at two clinic firms at a VA Medical Center in Chicago. Eligible patients were men, age 50 and older, had no personal or family history of colorectal cancer or polyps, had not received colorectal cancer screening, and had at least one visit to the clinic during the study period. Health care providers in the intervention firm attended a workshop on colorectal cancer screening. Every 4-6 months they attended quality improvement workshops where they received group screening rates, individualized confidential feedback, and training on improving communication with patients with limited literacy skills. Medical records were reviewed for colorectal cancer screening recommendations and completion. Literacy level was assessed in a subset of patients. In the cost-effectiveness analysis, resource and cost estimates were derived.

Status:

The project is complete.

Eligibility criteria: Inclusion Criteria:

Patients over 50 with average risk for colorectal cancer. Patients with family history and/or personal history excluded, as well as those up to date on colorectal cancer screening.

Exclusion Criteria:

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Jesse Brown VA Medical Center Community-Based Outpatient Clinic Lake Side Divison, Chicago, IL
state: Illinois
Study officials:
affiliation: Jesse Brown VA Medical Center Community-Based Outpatient Clinic Lake Side Divison, Chicago, IL
name: Charles L. Bennett, MD PhD MPP
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04136522: Usefulness of the Artery First Approach in Pancreatic Cancer Surgery
Official title: A Prospective Randomized Study of the Usefulness of the Artery First Approach in Pancreatic Cancer With Pancreaticoduodenectomy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pancreatic Cancer, Adult
Margin, Tumor-Free
Surgery Site Fistula
Recurrence Tumor
Lead sponsor: Asan Medical Center
Sponsor class: OTHER
First posted: 2019-10-23
Enrollment: 268
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is aimed to evaluate difference of the 2 year recurrence free survival after pancreaticoduodenectomy for pancreatic cancer between artery-first approach and conventional procedure groups.

Detailed description: The patients will be divided into 2 groups

conventional group: The patients who included this group will undergo conventional pancreaticoduodenectomy (PD) or pylorus preserving pancreaticoduodenectomy (PPPD). We will identify and isolate superior mesenteric vein (SMV) before pancreatic resection. The surgeon will dissect tissue around superior mesenteric artery (SMA) and uncinate process of pancreas along the SMA.

Experimental group:

The patients who included this group will undergo PD or PPPD including total pancreatic mesopancreas excision and superior mesenteric artery approach. Before pancreatic transection, the surgeon will isolate superior mesenteric vein (SMV) and superior mesenteric artery (SMA). And the surgeon will dissect nerve plexus and lymph node around SMA. inferior pancreaticoduodenal artery (IPDA) and first jejunal artery will be identified and the surgeon will ligate according to surgical margin. Anastomosis will be performed as usual manners.

Postoperative manage is same in two groups. The investigators will compared 2 years recurrence free survival rate between conventional and experimental groups.

Eligibility criteria: Inclusion Criteria:

* Resectable pancreatic head cancer
* No systemic metastasis
* Age \> 20 years
* The patients who understand informed consent and is able to agree with study

Exclusion Criteria:

* The patients who have systemic metastasis
* The patients who need neoadjuvant therapy in borderline resectable and locally advanced pancreatic cancer
* Those with active or uncontrolled infections
* Those with severe psychiatric / neurological disorders
* Alcohol or other drug addicts
* Patients with moderate or severe comorbidities who are thought to have an impact on quality of life or nutritional status (cirrhosis, chronic kidney failure, heart failure, etc.)

Primary outcomes:
measure: 2 years recurrence free survival
timeFrame: 2 years after surgery
Secondary outcomes:
measure: R0 resection
timeFrame: 7-10 days after surgery
measure: Recurrence pattern
timeFrame: 2 years after surgery
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Asan medical center
Study officials:
affiliation: Asan Medical Center
name: Song-Cheol Kim, MD.PhD
role: PRINCIPAL_INVESTIGATOR
References: