Clinical trial NCT03471689: Multisensory Integration and Pain Perception
Official title: Multisensory Integration and Pain Perception
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Pain
Regulation, Self
Keywords: Multimodal
Pain perception
Regulation
Mindfulness
Lead sponsor: Wake Forest University Health Sciences
Sponsor class: OTHER
Collaborators: name: Wake Forest University
First posted: 2018-03-20
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 23
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Pain is a predominant disruption of well-being among humans. Feeling pain is a multimodal sensory experience where information is collected and processed from various senses such as sight and touch. Because pain is complex, variable, and experienced differently by each individual, finding more accessible and practical treatments for pain are necessary. Mindfulness meditation (MM) aims to reduce pain by directing focus to perceive thoughts through non-judgmental awareness. Positive reappraisal (PR) is a possible cognitive pain treatment that focuses on changing the meaning of stressful or negative events into positive, benign, valuable, or beneficial. When a stressful event, such as experiencing pain, is positively reappraised, the individual recognizes and engages with the feeling of stress produced by the event and intentionally looks for benefits that change the feeling from negative to positive. The focus of this study is to examine the effect of different cognitive techniques on multimodal innocuous and noxious stimuli. Visual and tactile noxious stimuli will be administered to determine how visual cue integrate to form and modulate the subjective experience of pain. The study team postulates that mindfulness meditation and positive reappraisal will significantly reduce pain in response to multimodal stimulus (visual cue + noxious heat) when compared to a non-manipulation control condition. These findings will be utilized to better understand the multidimensional mechanisms supporting nociception and the cognitive modulation of pain.


Eligibility criteria: Inclusion Criteria:

* Native/fluent English speaker
* Ability to understand/willingness to sign consent form

Exclusion Criteria:

* Chronic pain
* Cardiac medications
* Diagnosis of mental illness or personality disorder
* Diagnosis of heart or lung conditions/hyper tension
* Taking psychiatric medications

Primary outcomes:
measure: Psychophysical Assessment of Pain
timeFrame: throughout study completion, up to 2 hours
measure: Assessment of Physiologic Measurements
timeFrame: throughout study completion, up to 2 hours
measure: Freiburg Mindfulness Inventory (FMI) (Short Form)
timeFrame: throughout study completion, up to 2 hours
measure: Ways of Coping Scale (WOCS-PR; Positive Reappraisal Subscale)
timeFrame: throughout study completion, up to 2 hours
measure: State Anxiety Inventory (SAI)
timeFrame: throughout study completion, up to 2 hours
measure: Pain Catastrophizing Scale (PCS)
timeFrame: throughout study completion, up to 2 hours
measure: Positive and Negative Affective Scale (PANAS)
timeFrame: throughout study completion, up to 2 hours
measure: Beck Depression Inventory (BDI)
timeFrame: throughout study completion, up to 2 hours
measure: Perceived Stress Scale (PSS)
timeFrame: throughout study completion, up to 2 hours
measure: VAS of Analgesia
timeFrame: throughout study completion, up to 2 hours
measure: VAS of Political Affiliation
timeFrame: throughout study completion, up to 2 hours
measure: VAS of Stress
timeFrame: throughout study completion, up to 2 hours
measure: Valence Ratings for Images
timeFrame: throughout study completion, up to 2 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Winston-Salem
country: United States
facility: Wake Forest University
state: North Carolina
Study officials:
affiliation: Wake Forest University
name: Christian Waugh, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Wake Forest University Health Science
name: Fadel Zeidan, PhD
role: PRINCIPAL_INVESTIGATOR
References: