Clinical trial NCT04449016: Effect of Ethnicity on Changes in VO2max and Cardiac Output in Response to Short-Term High Intensity Interval Training
Official title: Effect of Ethnicity on Changes in VO2max and Cardiac Output in Response to Short-Term High Intensity Interval Training
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Improved VO2max and Cardiac Output in Response to Training
Keywords: HIIT
Inactive
Women
Lead sponsor: California State University, San Marcos
Sponsor class: OTHER
First posted: 2020-06-26
Enrollment: 22
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: This study was a longitudinal, repeated measures between subjects design.
Primary purpose: PREVENTION

Brief summary: The purpose of this study was to determine if ethnicity alters training responsiveness to a low dose of high intensity interval training in inactive women.

Detailed description: Prior to the session, women completed a 4-minute warmup at 10 % PPO. Each subject completed 9 sessions of HIIT over a 3-week period which consisted of eight to ten 1-minute bouts of cycling at 85% PPO with 75-second recovery between bouts at 10 % PPO. This protocol is well-tolerated in inactive individuals. Continuously during each session, heart rate was monitored using telemetry. On days 1, 3, 6, and 9 of training, the physical activity enjoyment scale (PACES) was completed. VO2max and cardiac output max were assessed prior to training, as well as post.

Eligibility criteria: Inclusion Criteria:

* Women
* Between the age of 18-45
* Healthy and non-obese (BMI \< 30 kg/m2)
* Perform less than 150 minutes per week of exercise in the last 12 months
* 100% Caucasian or 100% Hispanic

Exclusion Criteria:

* Injured
* Obese
* Active
* Mixed ethnicity

Primary outcomes:
measure: Change in baseline in VO2max at 3 weeks
timeFrame: 3 weeks
measure: Change in baseline in cardiac output max at 3 weeks
timeFrame: 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: San Marcos
country: United States
facility: California State University San Marcos
state: California
Study officials:
affiliation: California State University, San Marcos
name: Todd Astorino, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Raleigh JP, Giles MD, Scribbans TD, Edgett BA, Sawula LJ, Bonafiglia JT, Graham RB, Gurd BJ. The impact of work-matched interval training on V̇O2peak and V̇O2 kinetics: diminishing returns with increasing intensity. Appl Physiol Nutr Metab. 2016 Jul;41(7):706-13. doi: 10.1139/apnm-2015-0614. Epub 2016 Feb 29.
citation: Astorino TA, White AC, Dalleck LC. Supramaximal testing to confirm attainment of VO2max in sedentary men and women. Int J Sports Med. 2009 Apr;30(4):279-84. doi: 10.1055/s-0028-1104588. Epub 2009 Feb 6.
citation: Astorino TA, Schubert MM, Palumbo E, Stirling D, McMillan DW, Cooper C, Godinez J, Martinez D, Gallant R. Magnitude and time course of changes in maximal oxygen uptake in response to distinct regimens of chronic interval training in sedentary women. Eur J Appl Physiol. 2013 Sep;113(9):2361-9. doi: 10.1007/s00421-013-2672-1. Epub 2013 Jun 11.
citation: Bowdon M, Marcovitz P, Jain SK, Boura J, Liroff KG, Franklin BA. Exercise Training in "At-Risk" Black and White Women: A Comparative Cohort Analyses. Med Sci Sports Exerc. 2018 Jul;50(7):1350-1356. doi: 10.1249/MSS.0000000000001580.
citation: Gill JM, Celis-Morales CA, Ghouri N. Physical activity, ethnicity and cardio-metabolic health: does one size fit all? Atherosclerosis. 2014 Feb;232(2):319-33. doi: 10.1016/j.atherosclerosis.2013.11.039. Epub 2013 Nov 23.
citation: Johnson JL, Slentz CA, Duscha BD, Samsa GP, McCartney JS, Houmard JA, Kraus WE. Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study. Atherosclerosis. 2004 Oct;176(2):371-7. doi: 10.1016/j.atherosclerosis.2004.05.018.
citation: Skinner JS, Jaskolski A, Jaskolska A, Krasnoff J, Gagnon J, Leon AS, Rao DC, Wilmore JH, Bouchard C; HERITAGE Family Study. Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study. J Appl Physiol (1985). 2001 May;90(5):1770-6. doi: 10.1152/jappl.2001.90.5.1770.