Clinical trial NCT05659420: High Intensity Interval Training in Chronic Heart Failure
Official title: The Effect of High-intensity Interval Training and Moderate Intensity Continuous Training on Cardiopulmonary Functions in Chronic Heart Failure
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Chronic Heart Failure
Cardiac Rehabilitation
Lead sponsor: Inha University Hospital
Sponsor class: OTHER
First posted: 2022-12-21
Enrollment: 60
Sex: ALL
Minimum age (years): 30
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to investigate the effect of high-intensity interval training and moderate intensity continuous training on cardiopulmonary functions in chronic heart failure.

Detailed description: enroll chronic heart failure patients into 3 randomized controlled group

* high intensity interval training
* moderate intensity continous training
* control

perform cardica rehab for 12 weeks, compare primary and secondary endpoints between baseline and 12 weeks results

Eligibility criteria: Inclusion Criteria:

* medically stable chronic heart failure
* NYHA II-III
* can perform cardiopulmonary exercise test
* after 3months with proper medication
* age 30 to 70
* ejection fraction\< 40%

Exclusion Criteria:

* contraindication to cardiopulmonary exercise test
* musculoskeletal problem who cannot perform cardiopulmonary exercise test
* cognition deficit who cannot understand directions
* severe medial illness

Primary outcomes:
measure: Maximal or peak oxygen consumption (VO2max or VO2peak, same meaning) (kg/ml/min)
timeFrame: compare baseline data with 12 weeks rehabilitation data
Secondary outcomes:
measure: Anaerobic threshold (kg/ml/min)
timeFrame: compare baseline data with 12 weeks rehabilitation data
measure: 6minute walk test (meter)
timeFrame: compare baseline data with 12 weeks rehabilitation data
measure: maximal heart rate (bpm)
timeFrame: compare baseline data with 12 weeks rehabilitation data
measure: systolic blood pressure (mmHg)
timeFrame: compare baseline data with 12 weeks rehabilitation data
measure: diastolic blood pressure (mmHg)
timeFrame: compare baseline data with 12 weeks rehabilitation data
measure: resting heart rate (bpm)
timeFrame: compare baseline data with 12 weeks rehabilitation data
measure: diastolic blood presure (mmHg)
timeFrame: compare baseline data with 12 weeks rehabilitation data
measure: depression scale by Patient Health Questionnaire
timeFrame: compare baseline data with 12 weeks rehabilitation data
measure: anxiety scale by Generalized Anxiety Disorder Scale
timeFrame: compare baseline data with 12 weeks rehabilitation data
measure: fatigue scale by fatigue severity scale
timeFrame: compare baseline data with 12 weeks rehabilitation data
measure: Quality of Life (QoL) questionnaire (MacNew)
timeFrame: compare baseline data with 12 weeks rehabilitation data
Other outcomes:
Locations:
city: Incheon
country: Korea, Republic of
facility: Inha University hospital
state: Kyunggi-do
Study officials:
affiliation: Department of physical medicine and rehabilitation, Inha University hospital
name: Kyung-Lim Joa, M.D.
role: PRINCIPAL_INVESTIGATOR
References: