Clinical trial NCT06471439: An Investigation of Different Type Single Limb Exercise Training Effects in Copd
Official title: An Investigation of Different Type Single Limb Exercise Training Effects on Functional Capacity, Arterial Stifness, Muscle Activation and Quality of Life in Chronic Obstructive Pulmonary Disease
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Exercise
Keywords: Chronic Obstructive Pulmonary Disease
Single Limb exercise
resistance training
continous exercise training
high intensity exercise training
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2024-06-24
Enrollment: 66
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: three different type one leg exercise intervention are apllied in patients with copd
Primary purpose: SUPPORTIVE_CARE

Brief summary: COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise limitation is observed in COPD. Especially, decreased exercise performance related to vascular and fatique in quadriceps muscle. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and fatigue are observed in COPD. One leg exercise training result is not enough to highlight these parameters.

Three types single leg exercise intervantion will be applied. Exercise capacity, muscle strength, lung function, electromyography, lactate and quality of life will be measured.

Detailed description: Three types single leg exercise intervantion will applied to COPD patients that devided three groups. One leg continuous exercise training will be aplied to one group. One leg HIIT exercise training will be aplied to other group. One leg resistance exercise training will be aplied to the last group.

Exercise capacity and muscle strength are assesed. Lung function is measured. Electormyography is recorded. Lactate and quality of life are measured.

Eligibility criteria: Inclusion Criteria:

* COPD patients that applied to physiotherapy
* Cooperation for tests
* without severe ortopedical and neurological disease
* without severe cardiovascular disease
* To volunteer for the study.

Exclusion Criteria:

* have an acute exacerbation or having exacerbation at last month
* hypoxemia (PaO2\<55mmHg)
* no cooperated to test without volunteer to study having ortophedical and neurological diesase that affecting of tests severe cardiovascular disease

Primary outcomes:
measure: six minute walk test
timeFrame: pre-intervention
Secondary outcomes:
measure: cardiopulmonary exercise test
timeFrame: beginning day 2
measure: one leg cardiopulmonary exercise test
timeFrame: beginning, day 3
measure: quadriceps muscle strength assesing (repeated measeure)
timeFrame: beginning day 1 and last day
measure: isometrics quadriceps muscle strength assesing
timeFrame: beginning day 1 and last day
measure: lung function
timeFrame: beginning day 1 and last day
measure: quality of life assesing
timeFrame: beginning day 1 and last day
measure: arterial stiffness
timeFrame: beginning day 2 and last day
measure: lactate measurement
timeFrame: beginning day 2 and last day
measure: electromyography measurement
timeFrame: beginning day 2 and last day
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Elif Kocaaga
Study officials:
affiliation: Hacettepe University
name: elif kocaaga, ms
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dolmage TE, Goldstein RS. Effects of one-legged exercise training of patients with COPD. Chest. 2008 Feb;133(2):370-6. doi: 10.1378/chest.07-1423. Epub 2007 Oct 9.
citation: Evans RA, Dolmage TE, Mangovski-Alzamora S, Romano J, O'Brien L, Brooks D, Goldstein RS. One-Legged Cycle Training for Chronic Obstructive Pulmonary Disease. A Pragmatic Study of Implementation to Pulmonary Rehabilitation. Ann Am Thorac Soc. 2015 Oct;12(10):1490-7. doi: 10.1513/AnnalsATS.201504-231OC.
citation: MacInnis MJ, Morris N, Sonne MW, Zuniga AF, Keir PJ, Potvin JR, Gibala MJ. Physiological responses to incremental, interval, and continuous counterweighted single-leg and double-leg cycling at the same relative intensities. Eur J Appl Physiol. 2017 Jul;117(7):1423-1435. doi: 10.1007/s00421-017-3635-8. Epub 2017 May 11.