louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01830998: Early Detection of Cognitive Dysfunction in Diabetes
Official title: Study of Cognitive Dysfunction and Diabetes
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Dementia
DM
MCI
Keywords: Dementia
Olfactory
Lead sponsor: Wuhan General Hospital of Guangzhou Military Command
Sponsor class: OTHER
First posted: 2013-04-12
Enrollment: 400
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with type 2 diabetes

Brief summary: The rate of cognitive decline due to ageing is increased 1.5-fold to 2.0-fold in individuals with type 2 diabetes.There are no established specific treatment measures to prevent or ameliorate cognitive impairments in patients with diabetes. we want to detecte early clinical dementia in diabete.

Detailed description: Clinically relevant cognitive decrements in relation to diabetes mainly occur during two crucial periods in life: the period of brain development in childhood, and the period when the brain undergoes neurodegenerative changes associated with ageing.Potential leads for treatment are to optimise glycaemic control and avoid and treat vascular risk factors.we want to detecte early clinical dementia in diabete by MMSE and Olfactory function.

Eligibility criteria: Inclusion Criteria:

* Patients with type 2 diabetes(Age\>50 years)

Exclusion Criteria:

* with stroke or other complications.

Primary outcomes:
measure: MMSE Olfactory function dementia
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan,chongqing
country: China
facility: Wuhan general hospital of Guangzhou command
state: Hubei
city: Wuhan
country: China
facility: Wuhan general hospital of Guangzhou Command
state: Hubei
city: Wuhan
country: China
facility: tongji Medical University
state: Hubei
Study officials:
References:
Clinical trial NCT04720898: LUNA-EMG to Enhance Motor Functions in Multiple Sclerosis
Official title: LUNA-EMG to Enhance Lower Limb Motor Functions in Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Multiple Sclerosis
Lead sponsor: University of Liege
Sponsor class: OTHER
Collaborators: name: Jean-François Kaux, MD PhD
name: Frank Houlmont
First posted: 2021-01-22
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the present study is to evaluate the effects of training performed with the LUNA-EMG system to enhance motor functions of the lower limb in multiple sclerosis. This is a randomized open-label trial. Patients will be randomized into the intervention group (LUNA-EMG, 30-45 minutes once a week for 12 weeks) or in the control group (standard care).

The effect of the training will be measured based on the muscular strength, walking tests, proprioception and a quality of life questionnaire.


Eligibility criteria: Inclusion Criteria:

* EDSS less or equal to 6.5
* Between 18 and 70 years old
* Having signed the informed consent

Exclusion Criteria:

* Acute pain syndrome
* Severe cognitive deficits
* Risk of fracture or unconsolidated fracture
* Rigid joints (spasticity, severe osteoarthritis and arthritis) or unstable joints
* Severe ataxia and apraxia
* Epilepsy
* Pacemakers and similar implants
* Insufficient skin conditions

Primary outcomes:
measure: Muscle strength in mV
timeFrame: 12 weeks
Secondary outcomes:
measure: Timed 25-Foot Walk, seconds
timeFrame: 12 weeks
measure: Timed Up and Go, seconds
timeFrame: 12 weeks
measure: Proprioception
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Tinlot
country: Belgium
facility: CNRF
state: Liege
Study officials:
References:
Clinical trial NCT05812898: Adding Deep Front Line Myofascial Release to Selected Exercises in Patients With Knee Osteoarthritis
Official title: Effects of Adding Deep Front Line Myofascial Release to Selected Exercises in Patients With Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Osteoarthritis
Keywords: myofascial release
Knee osteoarthritis
Deep front line
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-04-14
Enrollment: 42
Sex: ALL
Minimum age (years): 45
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: exercise plus myofascial release of the adductor and tipialis posterior muscles.
Primary purpose: TREATMENT

Brief summary: the aim of the study is to investigate the effect of deep front line myofascial release to selected exercises in patients with knee osteoarthritis

Detailed description: : Knee osteoarthritis (KOA) also known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage.

The myofascial meridian is a new approach to the facial restriction .the knee capsules, the adductor muscles and the tipialis posterior are part of the deep front line which is a line of the myofascial meridian.

Exercise is the highest evidence in the treatment of knee osteoarthritis. The myofascial release is effective in the treatment of knee osteoarthritis so the study will investigate the effect of adding deep front line myofascial release to selected exercises in patients with knee osteoarthritis.

Eligibility criteria: Inclusion Criteria:

* Mild to moderate unilateral or bilateral medial tibiofemoral OA grade II-III (K/L).
* The age of the participants will range from 45 to 60 years old .
* BMI ranged from 20-30 kg/m2

Exclusion Criteria:

1. Severe knee OA (grade IV according to K/L classification).
2. Congenital or acquired inflammatory, rheumatic or neurological (systemic or local) diseases involving the knee.
3. Patients receiving oral or injected corticosteroids for the last 3 months .
4. History of knee surgery/fracture.
5. Patients with ACL and meniscus injury

Primary outcomes:
measure: pain intensity
timeFrame: up to four weeks
measure: function
timeFrame: up to four weeks
measure: rang of motion
timeFrame: up to four weeks
measure: joint position sense
timeFrame: up to four weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Hoda Mohamed Ahmed
Study officials:
affiliation: phyical therapist at Cairo university hospitals
name: hoda m Ahmed, bachelor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01608945: Prospective Randomized Study of Glucocorticoids in the Impact of the Liver Function and the Prognosis After Hepatectomy of HCC
Study type: OBSERVATIONAL
Overall status: SUSPENDED
Conditions: Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver
Keywords: steroid
liver function
prognosis
Lead sponsor: Eastern Hepatobiliary Surgery Hospital
Sponsor class: OTHER
First posted: 2012-05-31
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 60

Brief summary: The major drawback of hepatic pedicle clamping is ischaemia-reperfusion injury with impairment of liver function. Perioperative steroid administration has been advocated to reduce liver damage. The aim of this prospective, randomized study was to determine whether steroid administration can reduce liver injury and impact the prognosis


Eligibility criteria: Inclusion Criteria:

* 18-70 years old
* diametre of the mass\>3cm.
* hcc

Primary outcomes:
measure: liver function
timeFrame: six months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01209845: Ketamine for Low Mood States in the ER
Official title: Low Dose Ketamine for Low Mood States: An Emergency Department Feasibility Study for Depressed Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Depression
Suicide Ideation
Keywords: depression
suicide ideation
emergency department
ketamine
Lead sponsor: Yale University
Sponsor class: OTHER
First posted: 2010-09-27
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The investigators hope to see if a commonly used drug such as ketamine could help depressed ER patients feel better and improve their mood quickly.

Detailed description: Rapid-onset antidepressants could have important clinical impact if their benefits extended to Emergency Department (ED) patients. We hope to explore the preliminary feasibility, tolerability and efficacy of single-dose, intravenous (IV) ketamine in depressed ED patients who presented with suicide ideation (SI).

The manuscript (article) for this study has been retracted because Yale University conducted an investigation that determined that the description of the research was not accurate. The article misrepresents both the protocol-specified doses and the actual delivered doses of ketamine.

Eligibility criteria: Inclusion Criteria:

* adults (\>18yrs) presenting to the Emergency department with symptoms of depression and/or suicide ideation (MADRS\>30) with ability to give informed consent.
* medically stable

Exclusion Criteria:

* psychosis, bipolar, or other significant physical or mental illness
* pregnancy
* non-voluntary status
* urine drug screen positive for drugs of abuse

Primary outcomes:
measure: Montgomery Asberg Depression Rating Scale (MADRS)
timeFrame: 40, 80, 120, 240 minutes after administration of drug
Secondary outcomes:
measure: recruitment success and retention of subjects in the ER
timeFrame: initial recruitment of eligible subjects in the ER and for two weeks after administration of drug
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Yale New Haven Hospital Emergency Department
state: Connecticut
Study officials:
affiliation: Yale University School of Medicine, Department of Emergency Medicine
name: Gregory L Larkin, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Larkin GL, Beautrais AL. A Preliminary Naturalistic Study of Low-Dose Ketamine for Depression and Suicide Ideation in the Emergency Department. Int J Neuropsychopharmacol. 2017 Jul 1;20(7):611. doi: 10.1093/ijnp/pyx035. No abstract available.
citation: Larkin GL, Beautrais AL. A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department. Int J Neuropsychopharmacol. 2011 Sep;14(8):1127-31. doi: 10.1017/S1461145711000629. Epub 2011 May 5.
Clinical trial NCT05485298: The Influence of the Volume of Injuries and Surgical Operations on the Results of Pain Treatment in Patients With Gunshot and Mine-explosive Wounds at the Stages of Treatment
Official title: The Influence of the Volume of Injuries and Surgical Operations on the Results of Pain Treatment in Patients With Gunshot and Mine-explosive Wounds at the Stages of Treatment
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Pain
Keywords: pain treatment, wounds, damage, operative interventions
Lead sponsor: Bogomolets National Medical University
Sponsor class: OTHER
First posted: 2022-08-03
Enrollment: 2215
Sex: MALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: all patients were injured during hostilities

Brief summary: Treatment of pain in patients with gunshot and mine-explosive injuries in the stages of treatment is important, because in 82.1% the pain becomes chronic. This indicates that treatment results need to be improved. One of the factors that can influence the outcome of pain treatment is the extent of damage and surgery.

Detailed description: The influence of the amount of damage and operative interventions on the results of pain treatment in patients with gunshot and mine-explosive wounds at the stages of treatment needs to be studied, because the subjective feelings and emotional experiences experienced by patients during the wounding in combat conditions through the prism of psychological disorders have its features. Since in 82.1% of cases it is not possible to achieve a positive result of treatment, the data of our study will play an important role in their treatment.

Eligibility criteria: Inclusion Criteria:

* the presence of gunshot wounds

Exclusion Criteria:

* no gunshot wounds

Primary outcomes:
measure: visual analog scale
timeFrame: 12 months
measure: Didier Bouhassiraa DN4
timeFrame: 12 months
measure: The Hospital Anxiety and Depression Scale
timeFrame: 12 months
measure: Chaban Quality of Life Scale
timeFrame: 12 months
measure: Mississippi PTSD scale (military version)
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Kyiv
country: Ukraine
facility: Bogomolets National Medical University, Ministry of Health of Ukraine
Study officials:
References:
Clinical trial NCT03083145: Protein Source, Nutrition Messaging, and Food Intake
Official title: Evaluating How Breakfast Protein Source Affects Satiety, Glucose and Food Preference
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Lead sponsor: University of Arkansas, Fayetteville
Sponsor class: OTHER
First posted: 2017-03-17
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The objective of this study is to determine how the protein source and the physical form of food consumed at breakfast impact food intake. Research will be conducted by assessing feelings of hunger, food preference and blood glucose in healthy adults following the ingestion protein-based (animal versus plant) drinks similar calorie and protein content.


Eligibility criteria: Inclusion Criteria:

* Healthy, no known health conditions

Exclusion Criteria:

* Taking medication, excluding hormonal birth control
* Food allergies
* Food intolerances

Primary outcomes:
measure: Appetite assessment
timeFrame: 2 hours
Secondary outcomes:
measure: Snack intake using checklist
timeFrame: 1 hour
Other outcomes:
Locations:
city: Fayetteville
country: United States
facility: University of Arkansas
state: Arkansas
Study officials:
References:
Clinical trial NCT04047745: Post-operative Exparel Study Following Rotator Cuff Repair
Official title: The Use of Liposomal Bupivacaine Interscalene Brachial Plexus Block for Rotator Cuff Surgery: A Randomized, Double Blind, Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Rotator Cuff Tears
Lead sponsor: Rothman Institute Orthopaedics
Sponsor class: OTHER
First posted: 2019-08-07
Enrollment: 132
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary purpose of this study is to determine if the postoperative oral narcotics consumption in patients receiving liposomal bupivacaine (LB) interscalene brachial plexus nerve block (ISBPB) is different than the narcotics consumption receiving traditional bupivacaine ISBPB for arthroscopic rotator cuff repair analgesia.


Eligibility criteria: Inclusion Criteria:

* Males and females aged 18 years or older with a full-thickness rotator cuff tear (confirmed on MRI) undergoing arthroscopic rotator cuff repair surgery.
* Anesthesiologists physical status 1, 2, or 3 and normal preoperative motor (Lovett scale: biceps, wrist, thumb) and sensory function.

Exclusion Criteria:

* Revision shoulder surgery
* History of more than 1 prior surgery performed on the operative shoulder
* Concomitant severe glenohumeral arthritis
* Concomitant adhesive capsulitis
* Worker's compensation claim
* Pregnancy
* History of hypersensitivity or idiosyncratic reaction to amide-type local anesthetics
* History of renal or hepatic failure
* Chronic neuromuscular deficit affecting the surgical limb.
* Uncontrolled psychiatric or neurologic disorder

Primary outcomes:
measure: opioid consumption
timeFrame: surgery through 48 hours post-op
Secondary outcomes:
Other outcomes:
Locations:
city: Egg Harbor Township
country: United States
facility: Rothman Orthopaedics at Egg Harbor Township
state: New Jersey
Study officials:
References:
Clinical trial NCT03103945: Prospective Physician-Initiated Observational Study of The Contact Detection System (CDS) in Patients Undergoing Radiofrequency Ablation Using the Niobe™ Remote Magnetic Navigation System
Official title: Prospective Physician-Initiated Observational Study of The Contact Detection System (CDS) in Patients Undergoing Radiofrequency Ablation Using the Niobe™ Remote Magnetic Navigation System (STAR)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Atrial Fibrillation
Catheter Ablation
Keywords: Atrial Fibrillation
Atrial Arrhythmia
Arrhythmias, Cardiac
Cardiac Diseases
Electrophysiologic Techniques, Cardiac
Electrophysiology
Remote Magnetic Navigation
Contact Detection System
Lead sponsor: Erasmus Medical Center
Sponsor class: OTHER
First posted: 2017-04-07
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Consecutive participant sampling of patients who will receive RF ablation of cardiac arrhythmias with the Niobe Remote Magnetic Navigation system.

Brief summary: This observational study evaluates peri-procedural results of the Niobe™ Remote Magnetic Navigation (RMN) ES system using the contact detection system (CDS) in patients undergoing standard of care radiofrequency ablation of cardiac arrhythmias.

The objective of this observational study is to confirm system performance of the CDS and that it does not alter pacing, electrocardiograms, or mapping during RF ablation procedures.


Eligibility criteria: Inclusion Criteria:

* patients with a clinical indication for RF ablation of cardiac arrhythmias with the Niobe Remote Magnetic Navigation system
* patients referred to one of the participating ablation centers
* written informed consent

Exclusion Criteria:

* presence of a atrial thrombus or left atrial appendage (LAA) thrombus seen on (contrast) echocardiography or MRI
* contra-indication for general anesthesia
* age below 18 years

Primary outcomes:
measure: Mapping quality
timeFrame: One day - during ablation procedure
measure: Pacing thresholds
timeFrame: One day - during ablation procedure
measure: Pacing capture
timeFrame: One day - during ablation procedure
measure: Electrocardiograms
timeFrame: 10 months - ECGs will be evaluated after inclusion is completed
Secondary outcomes:
measure: Number of procedure related major adverse events, attributed to the CDS system
timeFrame: 30 days
measure: Number of procedure related minor adverse events, attributed to the CDS system
timeFrame: 30 days
measure: Number of acute procedure succes
timeFrame: 1 day - during ablation procedure
Other outcomes:
Locations:
city: Rotterdam
country: Netherlands
facility: Erasmus MC
state: Zuid Holland
Study officials:
References:
Clinical trial NCT00483145: Laser-Mediated Photodynamic Therapy of Acne Vulgaris and Rosacea
Official title: Laser-Mediated Photodynamic Therapy of Acne Vulgaris and Rosacea
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acne Vulgaris and Rosacea
Lead sponsor: Bispebjerg Hospital
Sponsor class: OTHER
First posted: 2007-06-06
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: To evaluate efficacy and adverse effect from long-pulsed dye laser versus long-pulsed dye laser-mediated photodynamic therapy for acne vulgaris and rosacea.


Eligibility criteria: Inclusion Criteria:

* Inflammatory acne and rosacea
* Skin types I-IV

Exclusion Criteria:

* Patients younger than 18 years
* Skin types V and VI
* Topical and systemic conventional acne treatments

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Copenhagen NV
country: Denmark
facility: Bispebjerg Hospital
Study officials:
affiliation: Bispebjerg Hospital
name: Merete Hædersdal
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06528145: Long Covid (Individuals with Ongoing COVID-19 Symptoms) Ongoing Effects
Official title: Comparison of Quality of Life and Functional Capacity of Long Covid Patients and Symptom-Free Volunteers: a Randomized Controlled Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19 Infection
Keywords: Long Covid
Quality of Life
COVID-19
Lead sponsor: Isparta University of Applied Sciences
Sponsor class: OTHER
Collaborators: name: Suleyman Demirel University
name: Pamukkale University
First posted: 2024-07-30
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who had an infection at Süleyman Demirel University Hospital at least 6 and up to 18 months ago and were re-admitted to the hospital due to symptoms were included.

Brief summary: Persistent Covid-19 symptoms, known as long Covid, can impact healthcare provision. This study aimed to assess how symptoms persisting six months after Covid-19 affect quality of life and functional capacity.


Eligibility criteria: Inclusion Criteria:

* The study included individuals who had Covid-19 disease at least 6-18 months ago, who agreed to participate, and who were diagnosed with Covid-19 by a health institu-tion during the disease period.

Exclusion Criteria:

* Individuals who were not between the ages of 18-65, who had cognitive and commu-nicative impairments, and who had orthopedic and neurological limitations that would prevent them from performing physical activity were excluded from the study.

Primary outcomes:
measure: Functional capacity, physical function, physical role difficulties, emotional role difficulties, pain and general health
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Isparta
country: Turkey
facility: Süleyman Demirel Univesity
Study officials:
References: