Clinical trial NCT05184335: Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia
Official title: Phase 3, Randomized, 28 Days, Double-blind, Placebo-controlled, Multicenter Study to Assess the Safety and Efficacy of Brilaroxazine (RP5063) in Subjects With Schizophrenia, Followed by a 52-Week Open-label Extension
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Schizophrenia
Lead sponsor: Reviva Pharmaceuticals
Sponsor class: INDUSTRY
First posted: 2022-01-11
Enrollment: 690
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This is a parallel group efficacy and safety study with 3 treatment arms (2 active, one placebo, randomized 1:1:1) that is blinded for participants and involved study staff except dedicated unblinded individuals in statistics and drug safety. The OLE part will provide RP5063 15 mg, 30mg or 50mg OD open label to all participants.
Primary purpose: TREATMENT

Brief summary: This study is to evaluate the effect and safety of Brilaroxazine in patients with acute schizophrenia compared to the placebo short and long-term. Brilaroxazine will be given at fixed doses of 15 mg or 50 mg once daily over 4 weeks, then in the long-term flexible doses 15-50mg daily over a period of 52 weeks.

Detailed description: This is a randomized, double-blind (DB), placebo-controlled, multicenter study to assess the efficacy and safety of RP5063 (brilaroxazine) at fixed doses of 15 mg or 50 mg, administered once daily (OD) for 28 days (28 days DB treatment) in subjects with an acute exacerbation of schizophrenia. The study further will assess the safety of RP5063 (brilaroxazine) at flexible doses of either 15, 30 or 50 mg administered OD in an Open Label (OL) treatment over a period of 52 weeks (52-week OL treatment part), in subjects with stable schizophrenia. The OL treatment will have 2 populations of stable schizophrenia: DB rollover and de novo subjects.

The study comprises 2 parts: a 28-day DB treatment, followed by 52 weeks OL treatment.

The total duration of the study is 56 weeks (28 days/4 weeks DB treatment and 52-weeks OL treatment).

Eligibility criteria: Inclusion Criteria:

1. Subject is male or female, aged 18 to 65 years
2. Subject reads, understands, and signs an Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved current ICF prior to performing any of the Screening procedures
3. Diagnosis schizophrenia

Exclusion Criteria:

1. Has a history of treatment resistance exhibited by any of the following:

   1. No or minimal response to at least 2 periods of treatment lasting 28 days or longer, with antipsychotic agents at the maximally tolerated dose.
   2. Lifetime history of clozapine use
   3. History of electroconvulsive therapy (ECT) for treatment of schizophrenia within the past 5 years.
2. Is treatment-naïve for schizophrenia.
3. Primary current diagnosis other than schizophrenia or a comorbid diagnosis that is primarily responsible for the current symptoms and functional impairment.
4. Has a current diagnosis of a psychotic disorder other than schizophrenia or a behavioral disturbance thought to be due to substance abuse disorder.
5. Meets criteria for moderate-to-severe substance use disorder within past 6 months prior to Screening (excluding those related to caffeine or nicotine).
6. Has a history of the following: (a) traumatic brain injury causing ongoing cognitive difficulties, Alzheimer's disease, or another form of dementia, or any chronic organic disease of the central nervous system (CNS) (b) intellectual disability of a severity that would impact ability to participate in the study.
7. Subject has a current primary DSM-5 diagnosis other than schizophrenia, including schizoaffective disorder, major depressive disorder, post-traumatic stress disorder, obsessive-compulsive disorder, manic episode, hypomania, panic disorder, delirium, amnestic or other cognitive disorders. Also, subjects with borderline, paranoid, histrionic, schizotypal, schizoid, or antisocial personality disorder.
8. On antipsychotic within the Screening Period (minimum 3 days prior to Baseline and throughout the study).
9. Within 28 days prior to Baseline: monoamine oxidase (MAO) inhibitors, CNS stimulants, potent CYP3A4/5 enzyme-inducing drugs including but not limited to rifampin and carbamazepine and strong CYP3A4/5 inhibitors like ketoconazole, itraconazole, clarithromycin, etc. (see Appendix 20.1 for prohibited medications).
10. Antipsychotic depot medication within 5 half-lives prior to Baseline.
11. Positive Urine Drug Screen for drugs of abuse, including amphetamines, barbiturates, cocaine, ecstasy, phencyclidine or opiates meeting criteria of moderate-to-severe DSM-5 substance use disorder.

Primary outcomes:
measure: Double Blind Safety and Efficacy of Brilaroxazine (RP5063)
timeFrame: 28 days
measure: Open label Safety and Efficacy of Brilaroxazine (RP5063)
timeFrame: 52 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Reviva site
state: Arizona
city: Bentonville
country: United States
facility: Reviva site
state: Arkansas
city: Little Rock
country: United States
facility: Reviva site
state: Arkansas
city: Rogers
country: United States
facility: Reviva site
state: Arkansas
city: Garden Grove
country: United States
facility: Reviva site
state: California
city: Lemon Grove
country: United States
facility: Reviva site
state: California
city: Riverside
country: United States
facility: Reviva site
state: California
city: Hollywood
country: United States
facility: Reviva site
state: Florida
city: Hollywood
country: United States
facility: Reviva site
state: Florida
city: Miami Lakes
country: United States
facility: Reviva site
state: Florida
city: Atlanta
country: United States
facility: Reviva site
state: Georgia
city: Decatur
country: United States
facility: Reviva site
state: Georgia
city: Chicago
country: United States
facility: Reviva site
state: Illinois
city: Gaithersburg
country: United States
facility: Reviva site
state: Maryland
city: Boston
country: United States
facility: Reviva site
state: Massachusetts
city: Oklahoma City
country: United States
facility: Reviva site
state: Oklahoma
city: Austin
country: United States
facility: Reviva site
state: Texas
city: Richardson
country: United States
facility: Reviva site
state: Texas
Study officials:
affiliation: Reviva Pharma
name: Medical Director
role: STUDY_DIRECTOR
References: