Clinical trial NCT06956963: Aerobic Exercise: A Potential Rescue From the Negative Ramifications of Poor Sleep
Official title: Aerobic Exercise: A Potential Rescue From the Negative Ramifications of Poor Sleep
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Cardiovascular Health
Sleep
Lead sponsor: Florida State University
Sponsor class: OTHER
First posted: 2025-05-04
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: The goal of this interventional study is to differentiate the effects of an acute partial sleep deprivation intervention on markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing in active vs sedentary individuals. The main aims of the project are:

* To differentiate the effects of partial sleep deprivation on central hemodynamics (i.e., central blood pressure and arterial stiffness) in active vs sedentary individuals.
* To differentiate the effects of partial sleep deprivation on physical (i.e., handgrip strength and reactive strength index) and cognitive performance (i.e., reaction time and impulse control) in active vs sedentary individuals.
* To differentiate the effects of partial sleep deprivation on overall wellbeing (i.e., cardio-autonomic function, inflammation levels, and psychological mood states) in active vs sedentary individuals.

Participants will be divided into two groups based on aerobic activity level - active or sedentary - and assessed for markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing before and after three days of normal sleep and three days of partially deprived sleep (i.e., 30% reduction in total time in bed).


Eligibility criteria: Inclusion Criteria:

* Chronically active (≥150 minutes of moderate- and/or ≥75 minutes of vigorous-intensity aerobic exercise per week for the last 3 months) OR
* Sedentary (≤60 minutes of aerobic exercise per week for the last 3 months)

Exclusion Criteria:

* Chronic, uncontrolled disease (cardiovascular, metabolic)
* Poor sleep (regularly achieving \<7 hours of sleep per night)
* Musculoskeletal injury in the last 6 months
* Obese (grade II or higher)
* Pregnant

Primary outcomes:
measure: Arterial Stiffness (i.e., carotid-femoral pulse wave velocity)
timeFrame: Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep
measure: Central Hemodynamics
timeFrame: Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep
Secondary outcomes:
measure: Cardio-Autonomic Function
timeFrame: Daily mid- and post- 3 days of partial sleep deprivation; daily mid- and post- 3 days for normal sleep
measure: Cardio-Autonomic Function
timeFrame: Daily mid- and post- 3 days of partial sleep deprivation; daily mid- and post- 3 days for normal sleep
measure: Cardio-Autonomic Function
timeFrame: Daily mid- and post- 3 days of partial sleep deprivation; daily mid- and post- 3 days for normal sleep
measure: Cognitive Performance
timeFrame: Daily mid- and post- 3 days of partial sleep deprivation; daily mid- and post- 3 days for normal sleep
measure: Cognitive Performance
timeFrame: Daily mid- and post- 3 days of partial sleep deprivation; daily mid- and post- 3 days for normal sleep
measure: Physical Performance
timeFrame: Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep
measure: Physical Performance
timeFrame: Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep
measure: Inflammation
timeFrame: Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep
measure: Inflammation
timeFrame: Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep
measure: Inflammation
timeFrame: Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep
measure: Inflammation
timeFrame: Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep
measure: Inflammation
timeFrame: Immediately- and 3 days-post 3 days of partial sleep deprivation; Immediately- and 3 days-post 3 days of normal sleep
Other outcomes:
Locations:
city: Tallahassee
country: United States
facility: Institute of Sports Sciences and Medicine
state: Florida
Study officials:
References: