Clinical trial NCT05173363: Influence of Square-stepping Exercise on Brain Activation, Cognitive Function and Physical Performance in Frail Elders With MCI
Official title: Influence of Square-stepping Exercise on Brain Activation, Cognitive Function and Physical Performance in Frail Elders With MCI
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Frailty
Mild Cognitive Impairment
Keywords: Square-stepping exercise
Frailty
Mild Cognitive Impairment
Lead sponsor: National Yang Ming Chiao Tung University
Sponsor class: OTHER
First posted: 2021-12-29
Enrollment: 25
Sex: ALL
Minimum age (years): 65
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Older adults with frailty and mild cognitive impairment

Brief summary: This study is to elucidate the possible mechanisms of SSE by examining brain activation differences between SSE patterns and usual walking, as well as the relationship between brain activity and SSE performance, between cognitive function and SSE performance, and between physical performance and SSE performance in frail elders with MCI.

Detailed description: Background:

Both frailty and MCI exert negative impact on motor and cognitive function, which increase the risks of fall and adverse health condition. SSE has been proved to be an effective intervention for motor and cognitive function in older adults. However, the underlying mechanisms of SSE still remain undetermined for its possible effects. This study aims to elucidate the possible mechanisms of SSE in frail elders with MCI.

Methods:

This is a cross-sectional study. The inclusion criteria are: (1) age between 65 and 90 years old, (2) the presence of at least 1 characteristic of the Fried frailty criteria, (3) with mini-mental state examination (MMSE) score≧24 and Montreal Cognitive Assessment (MoCA) score \<26 (MCI criteria), and (4) ability to walk independently for 1 min without assistive devices. The exclusion criteria are: (1) central nervous system disorders (such as stroke, Parkinson's disease, spinal cord injury), and (2) any unstable physical condition, psychiatric disorder, and other neurological disorder or diagnosed with learning disability which may affect participating this study. Brain activity during SSE and usual walking, SSE performance, physical performance, and cognitive function are measured. The purpose of this study is to elucidate the possible mechanisms of SSE by examining brain activation differences between SSE patterns and usual walking, as well as the relationship between brain activity and SSE performance, between cognitive function and SSE performance, and between physical performance and SSE performance in frail elders with MCI.

Eligibility criteria: Inclusion Criteria:

* Age between 65 and 90 years old
* Presence of at least 1 characteristic of the Fried frailty criteria
* Mini-mental state examination score equal to or more than 24
* Montreal Cognitive Assessment score less than 26
* Ability to walk independently for 1 min without assistive devices

Exclusion Criteria:

* Central nervous system disorders (such as stroke, Parkinson's disease, spinal cord injury)
* Any unstable physical condition, psychiatric disorder, and other neurological disorder or diagnosed with learning disability which may affect participating this study

Primary outcomes:
measure: Brain activity
timeFrame: 20 minutes
measure: SSE performance
timeFrame: 15 minutes
measure: Montreal Cognitive Assessment
timeFrame: 15 minutes
measure: Trail making test
timeFrame: 5 minutes
measure: Stroop color and word test
timeFrame: 5 minutes
measure: Digit span test
timeFrame: 8 minutes
measure: Timed up and go test
timeFrame: 5 minutes
measure: Berg balance scale
timeFrame: 15 minutes
measure: Five times sit to stand test
timeFrame: 3 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Yang Ming Chiao Tung University
Study officials:
References: