Clinical trial NCT04676958: viTAmin K2 and rEcOVery From ExeRcise
Official title: Effects of Vitamin K2 on Recovery From Muscle Damaging Exercise in Young and Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Inflammation
Oxidative Stress
Vitamin K
Exercise
Strength
Recovery
Lead sponsor: University of Glasgow
Sponsor class: OTHER
Collaborators: name: Kappa Bioscience
First posted: 2020-12-21
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of the current study, therefore, is to investigate the effects of vitamin K2 supplementation on the physiological responses to an acute bout of resistance exercise.


Eligibility criteria: Inclusion Criteria:

* Participant is able and willing to sign the Informed Consent From
* No plans to change lifestyle (activity and nutrition) during the study period
* Older group (n=40): 65 years of age or older.
* Younger group (n=40): Aged 18-40 years

Exclusion Criteria:

* Not currently, or in the last year, participating in more than 1h per week of vigorous aerobic physical activity or any resistance exercise
* BMI \> 30 kg/m2
* diabetes
* severe cardiovascular disease
* seizure disorders
* liver disease
* uncontrolled hypertension (\>150/90mmHg at baseline measurement)
* cancer or cancer that has been in remission \<5 years
* ambulatory impairments which would limit ability to perform assessments of muscle function
* dementia
* currently taking Vitamin K2 supplements
* currently taking Vitamin K antagonists/anticoagulants (e.g. warfarin)
* current smoking
* history of drug abuse
* taking medication known to affect muscle (e.g. steroids).

Primary outcomes:
measure: Change in post exercise recovery of muscle strength
timeFrame: Change from baseline to 12 weeks
Secondary outcomes:
measure: Change in pain free range of motion during knee extension exercise
timeFrame: Change from baseline to 12 weeks
measure: Change in post exercise recovery of functional abilities
timeFrame: Change from baseline to 12 weeks
measure: Change in post exercise recovery of sEMG activity
timeFrame: Change from baseline to 12 weeks
measure: Change in post exercise interleukin-6
timeFrame: Change from baseline to 12 weeks
measure: Change in post exercise peroxiredoxin 3 redox state
timeFrame: Change from baseline to 12 weeks
measure: Change in vitamin K levels
timeFrame: Change from baseline to 12 weeks
measure: Change in Carboxylated Osteocalcin levels
timeFrame: Change from baseline to 12 weeks
measure: Change in uncarboxylated Osteocalcin levels
timeFrame: Change from baseline to 12 weeks
measure: Change in carboxylated matrix gla-protein levels
timeFrame: Change from baseline to 12 weeks
measure: Change in dephosphorylated-uncarboxylated matrix gla-protein levels
timeFrame: Change from baseline to 12 weeks
measure: Change in post exercise F2 isoprostanes
timeFrame: Change from baseline to 12 weeks
Other outcomes:
measure: Change in lean mass
timeFrame: Change from baseline to 12 weeks
measure: Change in blood glucose
timeFrame: Change from baseline to 12 weeks
measure: Change in blood lipids
timeFrame: Change from baseline to 12 weeks
measure: Change in plasma insulin
timeFrame: Change from baseline to 12 weeks
measure: Change in fat mass
timeFrame: Change from baseline to 12 weeks
measure: Change in muscle thickness
timeFrame: Change from baseline to 12 weeks
measure: Change in exercise substrate utilisation
timeFrame: Change from baseline to 12 weeks
Locations:
city: Glasgow
country: United Kingdom
facility: University of Glasgow
city: Glasgow
country: United Kingdom
facility: Stuart Robert Gray
Study officials:
References: