louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05463146: Effects of Deep Breathing Excer. With & Without PMR on Post C Section LBP, QOS & PA
Official title: Effects of Deep Breathing Excercises With and Without Progressive Muscle Relaxation Technique on Post Cesarean Section Low Back Pain, Quality of Sleep and Physical Activity.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cesarean Section Complications
Keywords: Cesarean section
Deep breathing excercises
Low back pain
Progressive muscle relaxation
Physical activity
Quality of sleep
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2022-07-18
Enrollment: 32
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To find out the Effects of deep breathing exercises with and without Progressive Muscle Relaxation Technique on Post Cesarean Section low back Pain, Quality of Sleep and Physical Activity


Eligibility criteria: Inclusion Criteria:

* Females who had caesarian section
* Age 20-35 years
* No contraindications to exercise stated by an obstetrician

Exclusion Criteria:

* Females having heart disease,
* Females with Diabetes mellitus,
* Pre-eclampsia or eclampsia
* Complications during the operation
* Diseases of the nervous system, e.g. MS, stroke, Respiratory diseases, Diabetes, Cancer \&rheumatic diseases

Primary outcomes:
measure: Lowback pain
timeFrame: 8 weeks
measure: Quality of sleep
timeFrame: 8 weeks
measure: Physical activity
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Jinnah hospital
state: Punjab
Study officials:
affiliation: Riphah International University
name: Hafiza Neelam Muneeb, MS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03585946: Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis
Official title: A Prospective Multicenter Cohort Study Assessing Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Stevens-Johnson Syndrome
Toxic Epidermal Necrolysis
Drug Reaction
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
First posted: 2018-07-13
Enrollment: 750
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults hospitalized with a diagnosis of Stevens Johnsons Syndrome/Toxic Epidermal Necrolysis confirmed by examination of a dermatologist and/or skin biopsy plus described appropriate clinical findings (epidermal necrosis plus two involved mucosal surfaces) presenting within one week of disease onset.

Brief summary: This is a prospective, multicenter cohort observational; study to compare treatment outcomes in patients admitted to the hospital with Stevens-Johnsons Syndrome/Toxic Epidermolysis, aiming to assess the utility of medical management. The hypothesis of this study is that one or more treatment options will demonstrate improved patient outcomes. The primary objectives are cessation of progression of disease, time to complete re-epithelialization, length of stay, and mortality rate in the treatment groups as compared to those receiving supportive care alone. Exploratory analyses will assess the cause, risk factors, and severity prediction factors associated with the disease.


Eligibility criteria: Inclusion Criteria:

* a diagnosis of Stevens Johnsons Syndrome/Toxic Epidermal Necrolysis confirmed by examination of a dermatologist and/or skin biopsy plus described appropriate clinical findings (epidermal necrosis plus two involved mucosal surfaces) presenting within one week of disease onset

Exclusion Criteria:

* Pregnancy
* Age \<18y
* Decisional impairment
* Incarceration
* Onset of skin separation \>7d

Primary outcomes:
measure: Mortality
timeFrame: 3 years
measure: Time to cessation of new lesion formation
timeFrame: 3 years
measure: Time to re-epithelialization
timeFrame: 3 years
measure: Hospital length of stay
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05160246: The Instant Effect of Kinesiology Taping in Patients With Knee OA
Official title: Investigation of the Instant Effect of Kinesiology Taping on Rectus Femoris Muscle on Muscle Activation, Physical Performance and Proprioception in Knee Osteoarthritis Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteoarthritis, Knee
Keywords: knee osteoarthritis
Kinesiotape
Physical performance
Muscle activation
Lead sponsor: Kırıkkale University
Sponsor class: OTHER
First posted: 2021-12-16
Enrollment: 40
Sex: ALL
Minimum age (years): 45
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to determine instant effect of kinesiology taping applied to the rectus femoris on muscle activation, physical performance and proprioception in patients with knee osteoarthritis.

Detailed description: 40 patients with knee OA will be included in the study. Intervention group and placebo group will be formed. Facilitation taping will be applied on the rectus femoris of the patients in the taping group. The patients in the placebo group will be placed tape on the rectus femoris without any tension. Muscle activation, physical performance and proprioception will be evaluated before taping and 30 minutes after taping.

Eligibility criteria: Inclusion Criteria:

* Patients aged 45-65 years,
* Patients with independent ambulation,
* Patients with Grade II-III knee osteoarthritis according to the Kellgren and Lawrence Classification,
* Patients not using NSAIDs during the study,
* Patients who volunteered to participate in the study

Exclusion Criteria:

* Patients with previous surgery on the lower extremities
* Patients with neuromuscular disease
* Patients with vestibular pathology
* Patients with diseases of the cardiopulmonary system,
* Patients with communication difficulties,
* Patients who have received physiotherapy or intra-articular injections in the last 6 months or who exercise

Primary outcomes:
measure: muscle activation
timeFrame: 5 minutes
Secondary outcomes:
measure: timed up and go test
timeFrame: 5 minutes
measure: 5 times sit-to-stand test
timeFrame: 1 minutes
measure: proprioception
timeFrame: 5 minutes
measure: WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index)
timeFrame: 5 minutes
Other outcomes:
Locations:
city: Kırıkkale
country: Turkey
facility: Kırıkkale University
Study officials:
affiliation: Kırıkkale University
name: Aylin ATAŞ
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tuzun EH, Eker L, Aytar A, Daskapan A, Bayramoglu M. Acceptability, reliability, validity and responsiveness of the Turkish version of WOMAC osteoarthritis index. Osteoarthritis Cartilage. 2005 Jan;13(1):28-33. doi: 10.1016/j.joca.2004.10.010.
citation: Ye W, Jia C, Jiang J, Liang Q, He C. Effectiveness of Elastic Taping in Patients With Knee Osteoarthritis: A Systematic Review and Meta-Analysis. Am J Phys Med Rehabil. 2020 Jun;99(6):495-503. doi: 10.1097/PHM.0000000000001361.
Clinical trial NCT04777669: Removing Background Talker Noise for Cochlear Implant Users
Official title: Removing Background Talker Noise for Cochlear Implant Users
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: Hearing Loss
Lead sponsor: York Sound Inc
Sponsor class: INDUSTRY
Collaborators: name: NYU Langone Health
First posted: 2021-03-02
Enrollment: 100
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: When hearing-impaired listeners are properly aided with a hearing aid (HA) or cochlear implant (CI), they are often able to comfortably maintain a conversation in quiet environments. However, in group environments, such as a large family dinner, restaurant, or other environment where multiple people are talking simultaneously, hearing-impaired listeners have great difficulty participating in conversations and frequently withdraw or avoid the situation. As such, it would be highly beneficial to implement an algorithm into HAs or CIs to remove background talkers ("babble") from the signal to reduce listening effort for the hearing-impaired listener and allow them to converse as if they were in a quiet environment. Although HAs and CIs frequently incorporate noise reduction algorithms, these algorithms are not effective when the background is babble. The problem of removing babble involves segregating speech from speech. Hence, the spectral properties of the signal and noise are extremely similar.

Despite these challenges, we developed an algorithm to remove background babble. In the following study will test the ability of cochlear implant users to understand speech with background babble noise using our noise reduction algorithm or no noise reduction algorithm. We hypothesize that CI users will be able to understand significantly more speech in babble noise when using our algorithm.


Eligibility criteria: Inclusion Criteria:

Subjects with CIs 12 years of age and older with no diagnosis of other communicative or cognitive disorders. Subjects must have native or native-like English proficiency.

Exclusion Criteria:

No diagnosed cognitive or communicative disorders (other than hearing loss), presence of acute/chronic otitis media, useable acoustic hearing, and non-English speaking.

Primary outcomes:
measure: Speech Recognition
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: New York University School of Medicine
state: New York
Study officials:
References:
Clinical trial NCT06396169: The Effect of Yoga Exercises and Callisthenic Exercises on the Quality of Life in Healthy Individuals
Official title: The Effect of Yoga Exercises and Callisthenic Exercises on the Quality of Life in Healthy Individuals
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Quality of Life
Exercise
Lead sponsor: KTO Karatay University
Sponsor class: OTHER
First posted: 2024-05-02
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: In this study, healthy individuals will be asked to do yoga exercises or a calisthenic exercise program. The effect of different exercise programs on quality of life will be investigated.

Detailed description: While yoga was a part of the philosophy of life in India, today it has become widespread as a physical and mental practice and has become a preferred approach to protect and improve physical functions, especially in healthy individuals. The word yoga means "union" and "unity". It is a group of practices or disciplines that mainly include physical movements , special breathing techniques and deep concentration. A study on this subject has shown that Yoga training applied to healthy individuals increases muscle strength, muscle endurance and flexibility, and reduces stress levels.

Calisthenic exercises; These are exercises that are performed by creating resistance only with your body weight, without the need for any equipment or gym. Calisthenic exercises are aerobic and dynamic exercises. Calisthenics exercises are a useful and useful exercise method that can be done at a fast pace, at different intensities, and can also be modified. Calisthenic exercises should be rhythmic and performed by counting. A study on this subject has shown that calisthenic exercises improve muscle strength and balance.

In this study, healthy individuals will be asked to do yoga exercises or a calisthenic exercise program. The effect of different exercise programs on quality of life will be investigated.

Eligibility criteria: Inclusion Criteria:

1. The ages of 18 - 45
2. No communication problems
3. Not having had a surgical operation in the last 6 months

Exclusion Criteria:

1. Individuals with musculoskeletal system problems that prevent them from exercising
2. Individuals who have respiratory problems when their physical activity increases
3. Individuals with a history of chest pain related and unrelated to physical activity
4. Individuals with chronic diseases

Primary outcomes:
measure: 36-Item Short Form Survey Instrument
timeFrame: The evaluation will be applied at the baseline and after study completion, an average of 2 months.
Secondary outcomes:
measure: Positive and Negative Affect Schedule (PANAS)
timeFrame: The evaluation will be applied at the baseline and after study completion, an average of 2 months.
Other outcomes:
Locations:
city: Konya
country: Turkey
facility: KTO Karatay University
Study officials:
affiliation: KTO Karatay University
name: Osman Karaca
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01302769: Ear Acupuncture for Acute Sore Throat.
Official title: Ear Acupuncture for Acute Sore Throat. A Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acute Sore Throat
Keywords: Acute Sore Throat
Ear Acupuncture
Lead sponsor: Mike O'Callaghan Military Hospital
Sponsor class: FED
First posted: 2011-02-24
Enrollment: 56
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare ear acupuncture plus standard of care versus standard therapy (anti-inflammatory medications) in the reduction of pain, reduction in oral anti inflammatory medication use, hours lost from work in acute sore throat.


Eligibility criteria: Inclusion:

* Male and female subjects (DoD beneficiaries), 18 years or older, with upper respiratory complaints and their primary symptom being acute sore throat.
* Minimum pain score of 5 points on an 11 point scale (0-10 with 10 being the worst pain)

Exclusion:

* History of significant gastrointestinal bleed
* Previous documented history of stage 2 kidney disease or worse
* Known Pregnancy
* History of gastric bypass surgery
* Known Peritonsillar abscess (PTA)
* Throat, mouth or esophageal cancer
* Chronic oral steroids use
* Absence of one or more ears
* Active cellulitis of ear
* Ear anatomy precluding identification of acupuncture landmarks
* Non-English speaking
* Use of Hearing Aids that preclude the use of ear acupuncture
* Allergy to Ibuprofen

Primary outcomes:
measure: Reduction in Pain
timeFrame: 48 hours per subject
measure: Ibuprofen Doses Taken
timeFrame: 48 hours per subject
measure: Missed Work Hours
timeFrame: 48 hours per subject
Secondary outcomes:
Other outcomes:
Locations:
city: Nellis Air Force Base
country: United States
facility: Mike O'Callaghan Federal Hosptial
state: Nevada
Study officials:
affiliation: Mike O'Callaghan Federal Hospital/Nellis Air Force Base
name: David Moss, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05158569: Comparison of Breathing Exercise for Hypertensive Patients
Official title: Effectiveness of Diaphragmatic Breathing vs. Slow Breathing Techniques on Blood Pressure and Health-related Quality of Life in Adults With Stage 1 Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Keywords: Stage 1 hypertension
Diaphragmatic breathing
Slow breathing
Quality of life
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2021-12-15
Enrollment: 32
Sex: ALL
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To determine the Effectiveness of diaphragmatic breathing vs. slow breathing techniques on blood pressure and Quality of life in adults with stage 1 hypertension. In accessible literature limited data was found on the comparison of different breathing techniques. The current study will compare the effect of slow vs. diaphragmatic breathing exercises and will demonstrate which one is more effective.

Detailed description: Literature reports that inspiratory muscle training is more effective in reducing Blood Pressure and voluntary diaphragmatic breathing at 10 or 6 breaths per minute for 10 min twice a day for 4 weeks is effective in producing positive outcomes in hypertensive patients.

Eligibility criteria: Inclusion Criteria:

* Patient having stage 1 hypertension, Diagnosed after 1 week BP charting

Exclusion Criteria:

* Patients taking antihypertensive medication Patient having comorbidities Smokers and women taking oral contraceptives

Primary outcomes:
measure: Blood Pressure
timeFrame: 4 weeks
Secondary outcomes:
measure: Health related Quality of life
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Swāt
country: Pakistan
facility: Zakir khan shaheed hospital matta
state: KPK
Study officials:
affiliation: Riphah International University
name: Mehwish Waseem, MSPT(CPPT)
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jones CU, Sangthong B, Pachirat O, Jones DA. Slow breathing training reduces resting blood pressure and the pressure responses to exercise. Physiol Res. 2015;64(5):673-82. doi: 10.33549/physiolres.932950. Epub 2015 Mar 24.
citation: Janet SK, Mangala Gowri P. Effectiveness of deep breathing exercise on blood pressure among patients with hypertension. Int J Pharma Bio Sci 2017; 8(1):B256-60.
citation: Ma X, Yue ZQ, Gong ZQ, Zhang H, Duan NY, Shi YT, Wei GX, Li YF. The Effect of Diaphragmatic Breathing on Attention, Negative Affect and Stress in Healthy Adults. Front Psychol. 2017 Jun 6;8:874. doi: 10.3389/fpsyg.2017.00874. eCollection 2017.
Clinical trial NCT06517069: Effect of TEAS Combined With Oxycodone on Postoperative Visceral Pain in Gynecologic Laparoscopic Patients
Official title: Effect of Transcutaneous Electrical Acupoint Stimulation Combined With Oxycodone on Postoperative Visceral Pain and Early Recovery Quality in Gynecologic Laparoscopic Patients
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Visceral Pain
Lead sponsor: Yangzhou University
Sponsor class: OTHER
First posted: 2024-07-24
Enrollment: 120
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To investigate the effect and feasibility of percutaneous acupoint stimulation combined with oxycodone on postoperative visceral pain in laparoscopic patients, and provided a clinical basis for optimizing perioperative pain management in laparoscopic patients.

Detailed description: Patients aged 18-65 years old, BMI 18-30kg/m2, ASA grade I or II were selected for gynecologic laparoscopic surgery (laparoscopic ovarian tumor stripping, laparoscopic uterine fibroid stripping, laparoscopic total hysterectomy) under general anesthesia from May 2024 to July 2024. Exclusion criteria: Patients who were allergic to the drugs used in the study, had confusion or cognitive impairment, contraindicated percutaneous acupoint electrical stimulation, abnormal cardiopulmonary and liver and kidney function, history of analgesic drug use within one week, history of diabetes, myocardial infarction, or cerebrovascular accident. Exclusion criteria: patients dropped out of the experiment midway or the data was not completely collected, the surgical method changed midway, the operation duration was less than 30 minutes or more than 2 hours, and patients with opioid and addictive drug dependence

Eligibility criteria: Inclusion Criteria:

* Age 18-65 years
* American Society of Anesthesiologists grade I-II
* Body mass index (BMI) 18.5-30 kg/m2;
* No ulceration or infection at the acupuncture stimulation site.

Exclusion Criteria:

* Allergic to the drugs used in the study;
* People with unclear consciousness or cognitive dysfunction;
* There are contraindications of percutaneous acupoint electrical stimulation;
* Abnormal cardiopulmonary and liver and kidney function;
* History of analgesic drug use within one week;
* History of diabetes, myocardial infarction or cerebrovascular accident.

Primary outcomes:
measure: the VAS score of postoperative visceral pain
timeFrame: 30 minutes after surgery、6 hours after surgery、24 hours after surgery、48 hours after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Yangzhou
country: China
facility: Affiliated Hospital of Yangzhou University
state: Jiangsu
Study officials:
References:
Clinical trial NCT00691769: Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia
Official title: Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Central Centrifugal Scarring Alopecia
Lichen Planopilaris
Discoid Lupus Erythematosus
Keywords: alopecia
lupus
Lead sponsor: Wake Forest University Health Sciences
Sponsor class: OTHER
First posted: 2008-06-05
Enrollment: 8
Sex: FEMALE
Minimum age (years): 30
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Wake Forest University Health Sciences Dermatology Clinic.

Brief summary: The purpose of this research study is to see if a specific protein that we are interested in is involved in scarring hair loss. If these proteins are involved, further genetic work may also better define the disease as well as future treatment options.

Detailed description: This is a single-center study, designed to evaluate the expression of Fas protein in skin biopsies of patients with scarring alopecia including fourteen patients with central centrifugal scarring alopecia (CCSA), three patients with lichen planopilaris (LP) and three patients with discoid lupus erythematosus (DLE). Skin biopsies of five healthy participants will be used as controls.

Eligibility criteria: Inclusion Criteria:

* Participants ages 30 years or older with a biopsy- proven diagnosis of CCSA.
* Undergone standard of care treatment for CCSA by a WFUSM Dermatologist
* Women of child bearing age will be required to have a negative pregnancy test in order to participate in the study
* Participants ages 30 years or older with a biopsy- proven diagnosis of LP.
* Participants ages 30 years or older with a biopsy- proven diagnosis of DLE.
* Healthy participants must be ages 30 years or older.

Exclusion Criteria:

* Age less than 30 years of age.
* Clinically evident bacterial or viral infection of the scalp.
* Pregnant or nursing woman of child-bearing potential.
* Participation in any other investigative research study involving study medication.
* Inability to return for the biopsy visit.

Primary outcomes:
measure: To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia (CCSA), lichen planopilaris (LP) and discoid lupus erythematosus (DLE) and in healthy controls.
timeFrame: 8 weeks
Secondary outcomes:
measure: To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia before and after treatment with intralesional and topical steroids.
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Winston-Salem
country: United States
facility: Wake Forest University Health Sciences Dermatology
state: North Carolina
Study officials:
affiliation: Wake Forest University Health Sciences
name: Amy McMichael, MD
role: PRINCIPAL_INVESTIGATOR
References: