louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06167824: Assessment of Predictive Role of [11C] Choline PET/CT on Survival in Prostate Cancer Patients With Biochemical Failure Without Androgen Deprivation Therapy
Official title: Assessment of Predictive Role of [11C] Choline PET/CT on Survival in Prostate Cancer Patients With Biochemical Failure Without Androgen Deprivation Therapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Prostate Cancer
Lead sponsor: IRCCS San Raffaele
Sponsor class: OTHER
First posted: 2023-12-13
Enrollment: 302
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients previously treated with radical prostatectomy, with progressive increase in PSA value in the absence of hormonal therapy and for whom there is knowledge of the main clinical and follow up data with particular attention to survival data.

Brief summary: Among all the patients who underwent PET/CT with choline at our Institute between 2004 and 2007 to restage the prostatic disease following biochemical recovery of the disease, in this retrospective study the patients previously treated with radical prostatectomy, who present a progressive increase in the PSA value in the absence of hormone therapy and of which there is knowledge of the main clinical and follow-up data, with particular attention to survival data.

The PET/CT study with Choline, being part of the normal standard diagnostic work-up of patients, was performed following the normal clinical protocol. With the retrospective analysis of the data, the time elapsed following the prostatectomy operation and the follow-up time after the Choline PET/CT study will be evaluated and patients who died due to prostate cancer will therefore be considered. Prostate cancer-specific survival, calculated as the interval between radical prostatectomy and death due to prostate cancer, will be used as the end point. The differences between prostate cancer-specific survival of patients with a positive choline PET/CT study and patients with a negative choline PET/CT study will be evaluated (log-rank test). Choline PET/CT will be considered positive if pathological findings with significant tracer uptake are identified. In the subpopulation of patients with a positive Choline PET/CT study, survival data will also be evaluated in relation to the site of positivity of the PET/CT study, in particular at the level of local recurrence, in the lymph node or skeletal site.


Eligibility criteria: Inclusion Criteria:

* patients previously treated with radical prostatectomy, with progressive increase in PSA value in the absence of hormonal therapy.

Exclusion Criteria:

* \< 18 years patients

Primary outcomes:
measure: PET/CT with coline in patients previously treated with radical prostatectomy.
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Milano
country: Italy
facility: Irccs San Raffaele
state: Italia
Study officials:
References:
Clinical trial NCT03736824: Correlation of Endoscopic Findings and Symptoms in Patients Undergoing the First Upper Gastrointestinal Endoscopy
Official title: Correlation of Endoscopic Findings and Symptoms in Patients Undergoing the First Upper Gastrointestinal Endoscopy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Symptoms and Signs
Malignancy
Ulcer Peptic
Lead sponsor: Shanghai Jiao Tong University School of Medicine
Sponsor class: OTHER
First posted: 2018-11-09
Enrollment: 5000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients undergoing the first upper gastrointestinal endoscopy were collected from January 2018 to December 2018 in Renji Hospital, Shanghai Jiaotong University School of Medicine.

Brief summary: Endoscopy is the best means of finding early stage of upper gastrointestinal diseases, especially early cancer and benign ulcers. Currently, most people still undergo upper gastrointestinal endoscopy due to discomfort, rather than a regular physical examination at a certain age. This study prospectively investigated the reason for undergoing the first upper gastrointestinal endoscopy in patients and found the correlation of endoscopic findings and symptoms.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing the first upper gastrointestinal endoscopy.

Exclusion Criteria:

* The patients had previously performed endoscopy and any esophageal, gastric or duodenal surgery.
* The patients couldn't complete the questionnaire survey under the guidance of physicians at the appointment of the upper gastrointestinal endoscopy.

Primary outcomes:
measure: Correlation of endoscopic findings and symptoms
timeFrame: Within two weeks after receiving the survey
Secondary outcomes:
measure: The proportion of various symptoms in patients undergoing the first upper gastrointestinal endoscopy
timeFrame: Within two weeks after receiving the survey
measure: The proportion of different upper gastrointestinal diseases
timeFrame: Within two weeks after receiving the survey
measure: The infection rate of Helicobacter Pylori
timeFrame: Within two weeks after receiving the survey
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Renji Hospital, Shanghai Jiaotong University School of Medicine
Study officials:
affiliation: School of Medicine, Shanghai Jiao Tong University
name: Hong Lu
role: STUDY_DIRECTOR
References:
Clinical trial NCT01863524: Screening for Abdominal Aortic Aneurysm Using a Portable Transthoracic Echocardiography Among Patients With Acute Coronary Syndrome
Official title: Screening for Abdominal Aortic Aneurysm Using a Portable Transthoracic Echocardiography (TTE) Among Patients With Acute Coronary Syndrome in Intensive Cardiac Care Unit.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Coronary Syndrome
Keywords: Abdominal Aortic Aneurysm (AAA),
Echocardiography (TTE),
Acute Coronary Syndrome (ACS)
Patients over 65 years old
Lead sponsor: HaEmek Medical Center, Israel
Sponsor class: OTHER
First posted: 2013-05-29
Enrollment: 90
Sex: ALL
Minimum age (years): 65
Maximum age (years): 100
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients over 65 years old with ACS admitted in Intensive Cardiac Care Unit, who will be examined by TTE.

Brief summary: The prevalence of Abdominal Aortic Aneurysm among 65 years old individuals worldwide is 1-2%. when diagnosis is confirmed by abdominal Ultrasound the prevalence is 5.5% in men and 1% in women.

As abdominal aortic aneurysm and coronary heart disease share common risk factors, patients with acute coronary syndrome represent a high risk population in which screening for another atherosclerotic site is recommended.

Patients admitted for ACS undergo routinely TTE. during the same study, TTE may offer the opportunity to evaluate the cardiac morphology and function and to screen for Abdominal Aortic aneurysm. It was reported by different studies that the Sensitivity of this technique was between 91-96% for AAA screening.

In addition, this method is cheap, available and requires only 2-3 minutes to be added to the standard TTE.

we plan to examine patients admitted with ACS in our Intensive Care Unit for screening AAA by TTE in subcostal views in addition to the standard TTE examination.


Eligibility criteria: Inclusion Criteria:

* patients over 65 years old with ACS. patients capable of reading, understanding and signing informed concent

Exclusion Criteria:

* suboptimal TTE windows

Primary outcomes:
measure: Abdominal aortic diameter measurement of 30 mm or more by portable transthoracic echocardiography, will be defined as abdominal aortic aneurysm.
timeFrame: Average time period of 72 hours.
Secondary outcomes:
Other outcomes:
Locations:
city: Afula
country: Israel
facility: HaEmek MC Cardiology depratment
city: Afula
country: Israel
facility: Haemek Medical Center
Study officials:
affiliation: Haemek Medical Center, Afula, Israel
name: Mohamad Jabaren, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06773624: Use of 68Ga-DOTATOC PET/CT-enterography for Detection of the Primary Lesion in Neuroendocrine Tumors of the Small Bowel
Official title: Evaluation of 68Ga-DOTATOC PET/CT-enterography for the Detection of the Primary Lesion in Neuroendocrine Tumors of the Small Bowel
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Small Bowel Neoplasia
Neuroendocrine (NE) Tumors
Lead sponsor: European Institute of Oncology
Sponsor class: OTHER
First posted: 2025-01-14
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The neuroendocrine neoplasms of the small intestine (Si-NENs) is a relatively rare malignancy. Surgical resection is the only curative treatment for the early-stage. It remains controversial its application for advanced metastatic gastroenteropancreatic neuroendocrine tumours (GEP-NETs).

The identification of metastatic disease and tumor grade are the most important prognostic factors in advanced GEPNETs. Therefore, precise staging and evaluation of disease burden with a reliable imaging method is crucial for determining the correct stage of the disease and consequently the correct treatment.

A unique feature of NeuroEndocrinal Tumors (NETs) is the expression of somatostatin receptors (SSTR) which can be targeted with radiolabeled peptides for imaging.

The Positron Emission Tomography-Computed Tomography (PET/CT) technique using somatostatin analogs labeled with the positron emitting isotope, 68Ga (68Ga-DOTA peptides), has been shown to offer advantages over conventional imaging modalities as well as additional important quantitative and qualitative diagnostic information.

The aim of this study is to calculate the sensitivity (SE), the specificity (SP), the positive and negative predictive values (PPV and NPV) and the overall accuracy of 68Ga-DOTATOC PET/CT-enterography in detecting in primary lesion and multifocality of siNETs.


Eligibility criteria: Inclusion Criteria:

* patients with small bowel neuroendocrine tumours
* tumors with any grade (from 1 to 3) and any Ki 67 percentage
* patients eligible for surgical resection

Exclusion Criteria:

* patients with synchronous other oncological disease
* patients with Inflammatory bowel disease
* patients Not eligible for surgery

Primary outcomes:
measure: Evaluation of predictive role of CT-Enterography and 68Ga-DOTATOC PET/CT in detecting siNETs
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Milan
country: Italy
facility: European Institute of Oncology
Study officials:
References:
Clinical trial NCT05884996: Kabat Training Program With Elastic Bands for Shoulder in Amateur Swimmers
Official title: Kabat Training Program in Diagonal Pattern With Elastic Bands for Shoulder in Amateur Swimmers. A Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy
Keywords: Swimming
Proprioceptive Neuromuscular Facilitation
Resistance Training
Lead sponsor: Universidad Europea de Madrid
Sponsor class: OTHER
First posted: 2023-06-01
Enrollment: 50
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: It has been shown that 90% of swimmers experience shoulder pain at some point in their career. During the macrocycle, swimmers present significant alterations in the muscular balance between external and internal rotators of the shoulder: the IR assumes much prominence in strength levels and RE goes progressively weaker.

furthermore, all overhead athletes (such as swimmers) present a glenohumeral Internal Rotation Deficit and an increase in External Rotation.

The objective of this study is to propose an exercise with an elastic band aimed to strengthening the RE of the shoulder to analyze the effects on the muscular balance between IR and RE. In addition, the effect caused in the limitation of internal rotation is going to be studied


Eligibility criteria: Inclusion Criteria:

* Healthy volunteers
* Swimmers minimum 2 times per week

Exclusion Criteria:

* Acute infection
* Shoulder pathology
* Neer and Hawkins-Kennedy test positive

Primary outcomes:
measure: change in ROM external rotation of the shoulder in degrees
timeFrame: Change from Baseline at 8 weeks
measure: change in ROM internal rotation of the shoulder in degrees
timeFrame: Change from Baseline at 8 weeks
measure: change in external rotation isometric strength of the shoulder in newton
timeFrame: Change from Baseline at 8 weeks
measure: change in internal rotation isometric strength of the shoulder in newton
timeFrame: Change from Baseline at 8 weeks
measure: change in scapular displacement in maximum flexion in centimeters
timeFrame: Change from Baseline at 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Villaviciosa De Odón
country: Spain
facility: Universidad Europea de Madrid
state: Madrid
Study officials:
affiliation: Universidad Europea de Madrid
name: José A Del Blanco, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05111496: Evaluation of the Radiological Dose Delivered to Risky Interventional Cardiology Patients (Optidose)
Official title: Evaluation of the Radiological Dose Delivered to Risky Interventional Cardiology Patients (Optidose)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: X-rays; Effects
Chronic Total Occlusion
Lead sponsor: Ramsay Générale de Santé
Sponsor class: OTHER
Collaborators: name: European Clinical Trial Experts Network
First posted: 2021-11-08
Enrollment: 85
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient over 18 years-old, requiring intervention with a predicted risk of exceeding the radiological threshold (Air Kerma\> 3Gy): complex coronary dilation, coronary recanalization

Brief summary: The purpose of this study is therefore to study the actual doses of X-rays delivered to the patient's skin during recanalization of a coronary artery in a context of Chronic Total Occlusion


Eligibility criteria: Inclusion Criteria:

* Patient over 18 years-old
* Patient requiring intervention with a predicted risk of exceeding the radiological threshold (Air Kerma\> 3Gy): complex coronary dilation, coronary recanalization
* Patient benefiting from a social protection insurance
* Patient having been informed and not objecting to this research

Exclusion Criteria:

* Patient refusal to participate in the study
* Patient with known radiosensitivity factors (eg: Lupus)
* Patient having had radiotherapy treatment of the thoracic region.
* Patient whose sum of radiation doses to the skin\> 0.5 Gy in the thoracic region in the 3 months preceding inclusion.
* Patient participating in another clinical study
* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision
* Pregnant or breastfeeding woman
* Patient hospitalized without consent.

Primary outcomes:
measure: Dose measured to the patient's skin at the entrance to the X-ray beam
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Lille
country: France
facility: Hôpital privé La Louvière
state: Haut De France
Study officials:
References:
Clinical trial NCT01596296: Foley Catheter Versus Dinoprostone Vaginal Insert for Induction of Labor in Parous Women at Term: A Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Failed Induction of Labor
Keywords: labor induction
transcervical foley catheter
dinoprostone
parous women
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2012-05-10
Enrollment: 154
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the effectiveness and safety of transcervical foley catheter as compared to dinoprostone vaginal insertion for preinduction cervical ripening and labor induction in term parous women with unfavorable cervix.


Eligibility criteria: Inclusion Criteria:

* singleton pregnancy
* parous women
* gestational age \>=37.0 weeks
* Bishop score \<=5
* intact amniotic membrane
* absence of labor
* live fetus with vertex presentation
* no previous uterine surgical procedure

Exclusion Criteria:

* major congenital anomaly

Primary outcomes:
measure: Successful labor induction
timeFrame: Twelve hours of initiating oxytocin on the first day of induction
Secondary outcomes:
measure: Cervical change in the bishop scores and cervical lengths induced by transcervical foley catheter and dinoprostone vaginal insertion
timeFrame: When transcervical foley catheter or dinoprostone was removed before adminitoring oxytocin
Other outcomes:
Locations:
city: Seongnam-si
country: Korea, Republic of
facility: Department of Obstetrics and Gynecology Seoul National University Bundang Hospital
state: Gyeonggi-do
Study officials:
affiliation: Seoul National University Bundang Hospital
name: Kyo Hoon Park, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01909596: Lateral Wedge Insoles With Arch Support in Knee Osteoarthritis
Official title: Does it Exist a Relationship Between Inclination Angle of Foot Orthoses and Varus Angle of the Knee in the Relief of the Knee Osteoarthritis Symptoms?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Medial Knee Osteoarthritis
Lead sponsor: Laval University
Sponsor class: OTHER
Collaborators: name: Natural Sciences and Engineering Research Council, Canada
name: Fonds de la Recherche en Santé du Québec
name: Ergorecherche Inc.
First posted: 2013-07-26
Enrollment: 24
Sex: ALL
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this is to test lateral foot orthoses with different amount of wedging to find a model that predicts the optimal lateral inclination of foot orthosis based on biomechanical or feelings measures. This study was a cross-sectional study with patients serving as their own control. The investigators recruited 24 knee osteoarthritis. Knee radiography and clinical angles measures was carried out before making orthoses, then motion analysis with an optoelectronic system was performed with each pair of foot orthoses. During motion analysis, five gait trials were carried out in each condition.


Eligibility criteria: Inclusion Criteria:

* Symptomatic medial knee osteoarthritis (OA ; Kellgren-Lawrence grade I, II or III) according to clinical and radiological criteria of the American College of Rheumatology
* Knee pain \> 31/100 (Western Ontario and McMaster Universities Arthritis Index - WOMAC)
* Moderately active
* Varus knee alignment equal or superior to 2°

Exclusion Criteria:

* Severe knee OA (K-L grade IV)
* Rheumatoid arthritis or other inflammatory arthritis
* Avascular necrosis
* History of periarticular fracture or septic arthritis
* Bone metabolic disease
* Pigmented villonodular synovitis
* Cartilaginous disease
* Neuropathic arthropathy
* Synovial osteochondromatosis
* Total or partial knee arthroplasty
* Flexion contracture of ipsi- or contra-lateral knee greater than 15°
* Hip or ankle joint damage with mobility limitation
* Obesity (BMI ≥ 40)
* Intra-articular corticosteroids injection in the affected knee during the two previous months
* Reduced mobility (Charnley class C)

Primary outcomes:
measure: Knee pain
timeFrame: At time of device receipt
measure: Knee adduction moment
timeFrame: At time of device receipt
Secondary outcomes:
measure: Foot orthoses comfort
timeFrame: At time of device receipt
Other outcomes:
Locations:
city: Québec
country: Canada
facility: Pavillon de l'Éducation Physique et des Sports - Université Laval
state: Quebec
Study officials:
affiliation: Laval University
name: Philippe Corbeil, PhD
role: STUDY_DIRECTOR
affiliation: Laval University
name: Yoann Dessery, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: Laval University
name: Étienne L Belzile, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00305396: Calcineurin Inhibitor Avoidance With Thymoglobulin and Sirolimus in Kidney Transplantation
Official title: Calcineurin Inhibitor Avoidance With Thymoglobulin and Sirolimus in Kidney Transplant Recipients.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Kidney Transplantation
Keywords: Kidney transplantation
immunosuppression
sirolimus
Thymoglobulin
Lead sponsor: Vanderbilt University
Sponsor class: OTHER
Collaborators: name: Genzyme, a Sanofi Company
First posted: 2006-03-21
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A prospective, single center, open-label, randomized trial of Thymoglobulin induction and sirolimus, prednisone, and mycophenolate mofetil versus Thymoglobulin induction and tacrolimus, prednisone, and mycophenolate mofetil in non-HLA identical living or deceased donor kidney transplant recipients.

Detailed description: Calcineurin inhibitor-associated nephrotoxicity may exacerbate chronic allograft nephropathy and reduce long-term kidney graft survival. Complete avoidance of calcineurin inhibitors may improve graft function as measured by serum creatinine and calculated GFR and improve long-term outcomes following kidney transplantation. We conducted a prospective, randomized, single-center study comparing sirolimus versus tacrolimus in kidney transplantation. Primary cadaver of non-HLA identical living donor recipients are randomized to received either sirolimus 5 mg QD (target level 8-12 ng/ml) or tacrolimus 0.075 mg/kg BID (target level 8-12 ng/ml). All patients also received Thymoglobulin 1.5 mg/kg x 4 doses, mycophenolate 1 gm BID, and prednisone. Main outcome measures are patient and graft survival, biopsy-proven acute rejection, serum creatinine, hyperlipidemia, post-transplant diabetes, and surgical and wound complications.

Eligibility criteria: Inclusion Criteria:

Primary cadaver or non-HLA identical living donor kidney transplant. -

Exclusion Criteria:

HIV HCV Pregnancy Age \< 18 years Malignancy

-

Primary outcomes:
measure: Patient and graft survival
measure: Biopsy proven acute rejection
measure: Serum creatinine
Secondary outcomes:
measure: Hyperlipidemia
measure: post-transplant diabetes
measure: wound infections
measure: lymphoceles
Other outcomes:
Locations:
city: Nashville
country: United States
facility: Vanderbilt University Medical Center/Nashville VA
state: Tennessee
Study officials:
affiliation: Vanderbilt University Medical Center
name: A. Tarik Kizilisik, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Flechner SM, Goldfarb D, Modlin C, Feng J, Krishnamurthi V, Mastroianni B, Savas K, Cook DJ, Novick AC. Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine. Transplantation. 2002 Oct 27;74(8):1070-6. doi: 10.1097/00007890-200210270-00002.