Clinical trial NCT03335644: The NutriNet-Santé Study
Official title: The NutriNet-Santé Study. A Web-based Prospective Cohort Study of the Relationship Between Nutrition and Health and of Dietary Patterns and Nutritional Status Predictors
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Diet, Food, and Nutrition
Exercise
Diseases Category
Cohort Studies
Adult
Anthropometry
Humans
Internet
Surveys and Questionnaires
Mortality
Keywords: determinants of dietary patterns and nutritional status
Food additives, Food processing
Exclusion diets, vegetarian diet, vegan diet
Organic food, pesticide exposure, sustainability
Gut microbiota
Food labeling
Dietary supplements
Food based dietary guidelines
Psychological determinants of food behavior
Geographical determinants of food behavior
Breastfeeding
Mental health
Cancer
Cardiovascular and cardiometabolic health
Multimorbidity
Lead sponsor: University of Paris 13
Sponsor class: OTHER
Collaborators: name: Institut National de la Santé Et de la Recherche Médicale, France
name: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
name: Conservatoire national des Arts et Métiers
First posted: 2017-11-08
Enrollment: 170000
Sex: ALL
Minimum age (years): 15
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The NutriNet-Santé study is a French ongoing web-based cohort launched in 2009 with the objective to study the associations between nutrition and health as well as the determinants of dietary behaviors and nutritional status. This cohort has been previously described in details (citations). Participants aged over 15 years with access to the Internet are recruited by vast multimedia campaigns. All questionnaires are completed online using a dedicated website (www.etude-nutrinet-sante.fr).

Brief summary: The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=171 000 as of 2021) focused on the complex link between nutrition and health status. It is characterized by a very detailed assessment of nutritional exposure and dietary behavior.

https://etude-nutrinet-sante.fr/ https://info.etude-nutrinet-sante.fr/en

Detailed description: NutriNet-Santé is a large-scale (n=171,000) web-based cohort coordinated by EREN, launched in France in 2009 to investigate nutrition and health relationships. All required ethics authorisations have been obtained (listed here). NutriNet-Santé participants regularly fill questionnaires through a dedicated and secure website, providing extensive, high-quality nutritional and non-nutritional data, including repeated data on socio-demographics and lifestyle (yearly), anthropometrics (every 6 months), dietary intake (every 6 months), physical activity (IPAQ questionnaire, yearly)5 and health status (every 6 months). NutriNet-Santé is characterised by a very detailed and up-to-date assessment of nutritional exposure and dietary behaviours. Usual dietary intakes are assessed at baseline and every 6 months thereafter through a series of 3 non-consecutive randomly assigned 24h dietary records. Daily energy, alcohol, micro- and macronutrient intakes are calculated using the published NutriNet-Santé food composition database (\>3,500 generic items). All major health events (e.g., cancers, cardio- and cerebrovascular diseases) are reported by the participants and validated by an expert committee of physicians based on medical records, and/or retrieved from the French National Health Insurance medico-administrative databases to limit potential reporting bias. In turn, mortality data are obtained from the exhaustive French National Mortality Registry (CépiDC). The number of incident events already registered is as follows: 4,200 cancers and 1,240 deaths. A sub-sample of the cohort (n=20,000) provided blood and urine samples, currently stored at -80°C in EREN's biobank.

Eligibility criteria: Inclusion Criteria:

* aged over 15 years
* access to internet

Exclusion Criteria:

* aged under 15 years

Primary outcomes:
measure: cancers using health questionnaire and/or the website for declaration of major health events
timeFrame: every 6 months after registration, up to 10 years of follow-up
measure: CVD using health questionnaire and/or the dedicated website for declaration of major health events
timeFrame: every 6 months after registration, up to 10 years of follow-up
measure: type 2 diabetes using health questionnaire and/or the website for declaration of major health events
timeFrame: every 6 months after registration, up to 10 years of follow-up
measure: hypertension using health questionnaire and/or the website for declaration of major health events
timeFrame: every 6 months after registration, up to 10 years of follow-up
measure: metabolic syndrome using health questionnaire and/or the website for declaration of major health events
timeFrame: every 6 months after registration, up to 10 years of follow-up
measure: depression using health questionnaire and/or the website for declaration of major health events
timeFrame: every 6 months after registration, up to 10 years of follow-up
measure: migraine using health questionnaire and/or the website for declaration of major health events
timeFrame: every 6 months after registration, up to 10 years of follow-up
measure: rheumatoid arthritis using health questionnaire and/or the website for declaration of major health events
timeFrame: every 6 months after registration, up to 10 years of follow-up
measure: cognitive decline using health questionnaire and/or the website for declaration of major health events
timeFrame: every 6 months after registration, up to 10 years of follow-up
measure: quality of life using the SF-36 questionnaire
timeFrame: every 6 months after registration, up to 10 years of follow-up
measure: Weight using anthropometric questionnaire
timeFrame: every year after registration, up to 10 years of follow-up
measure: Height using anthropometric questionnaire
timeFrame: every year after registration, up to 10 years of follow-up
measure: Mortality
timeFrame: continuously updated
measure: Mental health (incl. anxious disorders, sleep disorders, addictive behaviors, eating disorders)
timeFrame: repeatedly during followup
measure: SARSCOV-2 (Covid 19) infection
timeFrame: regular update for a subsampe of the cohort from 2020
measure: multi-morbidity (mental and physical health)
timeFrame: continuous update
Secondary outcomes:
Other outcomes:
Locations:
city: Bobigny
country: France
facility: EREN
state: Seine Saint Denis
Study officials:
References:
citation: Hercberg S, Castetbon K, Czernichow S, Malon A, Mejean C, Kesse E, Touvier M, Galan P. The Nutrinet-Sante Study: a web-based prospective study on the relationship between nutrition and health and determinants of dietary patterns and nutritional status. BMC Public Health. 2010 May 11;10:242. doi: 10.1186/1471-2458-10-242.
citation: Kesse-Guyot E, Alles B, Brunin J, Fouillet H, Dussiot A, Mariotti F, Langevin B, Berthy F, Touvier M, Julia C, Hercberg S, Lairon D, Barbier C, Couturier C, Pointereau P, Baudry J. Nutritionally adequate and environmentally respectful diets are possible for different diet groups: an optimized study from the NutriNet-Sante cohort. Am J Clin Nutr. 2022 Dec 19;116(6):1621-1633. doi: 10.1093/ajcn/nqac253.
citation: Bellicha A, Wendeu-Foyet G, Coumoul X, Koual M, Pierre F, Gueraud F, Zelek L, Debras C, Srour B, Sellem L, Kesse-Guyot E, Julia C, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M. Dietary exposure to acrylamide and breast cancer risk: results from the NutriNet-Sante cohort. Am J Clin Nutr. 2022 Oct 6;116(4):911-919. doi: 10.1093/ajcn/nqac167.
citation: Reuze A, Mejean C, Carrere M, Sirieix L, Druesne-Pecollo N, Peneau S, Touvier M, Hercberg S, Kesse-Guyot E, Alles B. Rebalancing meat and legume consumption: change-inducing food choice motives and associated individual characteristics in non-vegetarian adults. Int J Behav Nutr Phys Act. 2022 Sep 1;19(1):112. doi: 10.1186/s12966-022-01317-w.
citation: Berthy F, Brunin J, Alles B, Fezeu LK, Touvier M, Hercberg S, Galan P, Pointereau P, Lairon D, Baudry J, Kesse-Guyot E. Association between adherence to the EAT-Lancet diet and risk of cancer and cardiovascular outcomes in the prospective NutriNet-Sante cohort. Am J Clin Nutr. 2022 Oct 6;116(4):980-991. doi: 10.1093/ajcn/nqac208.
citation: Gisch UA, Robert M, Berlin N, Nebout A, Etile F, Teyssier S, Andreeva VA, Hercberg S, Touvier M, Peneau S. Mastery Is Associated With Weight Status, Food Intake, Snacking, and Eating Disorder Symptoms in the NutriNet-Sante Cohort Study. Front Nutr. 2022 May 25;9:871669. doi: 10.3389/fnut.2022.871669. eCollection 2022.
citation: Robert M, Shankland R, Bellicha A, Kesse-Guyot E, Deschasaux-Tanguy M, Andreeva VA, Srour B, Hercberg S, Touvier M, Leys C, Peneau S. Associations between Resilience and Food Intake Are Mediated by Emotional Eating in the NutriNet-Sante Study. J Nutr. 2022 Aug 9;152(8):1907-1915. doi: 10.1093/jn/nxac124.
citation: Rebouillat P, Vidal R, Cravedi JP, Taupier-Letage B, Debrauwer L, Gamet-Payrastre L, Guillou H, Touvier M, Fezeu LK, Hercberg S, Lairon D, Baudry J, Kesse-Guyot E. Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Sante cohort. Environ Health. 2022 May 25;21(1):57. doi: 10.1186/s12940-022-00862-y.
citation: Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaesse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Alles B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M. Artificial sweeteners and cancer risk: Results from the NutriNet-Sante population-based cohort study. PLoS Med. 2022 Mar 24;19(3):e1003950. doi: 10.1371/journal.pmed.1003950. eCollection 2022 Mar.
citation: Deschasaux-Tanguy M, Srour B, Bourhis L, Arnault N, Druesne-Pecollo N, Esseddik Y, de Edelenyi FS, Allegre J, Alles B, Andreeva VA, Baudry J, Fezeu LK, Galan P, Julia C, Kesse-Guyot E, Peneau S, Hercberg S, Bajos N, Severi G, Zins M, de Lamballerie X, Carrat F, Touvier M; SAPRIS-SERO study group. Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Sante cohort. BMC Med. 2021 Nov 30;19(1):290. doi: 10.1186/s12916-021-02168-1.
citation: Debras C, Chazelas E, Srour B, Julia C, Kesse-Guyot E, Zelek L, Agaesse C, Druesne-Pecollo N, Andreeva VA, Galan P, Hercberg S, Latino-Martel P, Deschasaux-Tanguy M, Touvier M. Glycaemic index, glycaemic load and cancer risk: results from the prospective NutriNet-Sante cohort. Int J Epidemiol. 2022 Feb 18;51(1):250-264. doi: 10.1093/ije/dyab169.
citation: Carra MC, Fessi S, Detzen L, Darnaud C, Julia C, Hercberg S, Touvier M, Andreeva VA, Bouchard P. Self-reported periodontal health and incident hypertension: longitudinal evidence from the NutriNet-Sante e-cohort. J Hypertens. 2021 Dec 1;39(12):2422-2430. doi: 10.1097/HJH.0000000000002941.
citation: Schneider E, Sabate JM, Bouchoucha M, Debras C, Touvier M, Hercberg S, Benamouzig R, Buscail C, Julia C. FODMAP Consumption by Adults from the French Population-Based NutriNet-Sante Cohort. J Nutr. 2021 Oct 1;151(10):3180-3186. doi: 10.1093/jn/nxab207.
citation: Courtois F, Peneau S, Salanave B, Andreeva VA, Roland-Cachera MF, Touvier M, Galan P, Hercberg S, Fezeu LK. Trends in breastfeeding practices and mothers' experience in the French NutriNet-Sante cohort. Int Breastfeed J. 2021 Jul 2;16(1):50. doi: 10.1186/s13006-021-00397-x.
citation: Julia C, Leroy P, Adjibade M, Assmann KE, Touvier M, Hercberg S, Soler LG, Kesse-Guyot E. Public health potential of guidelines-based dietary scores for non-communicable diseases mortality prevention: simulation study using the Preventable Risk Integrated ModEl (PRIME) model. Public Health Nutr. 2021 Nov;24(16):5539-5549. doi: 10.1017/S1368980021002871. Epub 2021 Jul 2.
citation: Deschasaux-Tanguy M, Druesne-Pecollo N, Esseddik Y, de Edelenyi FS, Alles B, Andreeva VA, Baudry J, Charreire H, Deschamps V, Egnell M, Fezeu LK, Galan P, Julia C, Kesse-Guyot E, Latino-Martel P, Oppert JM, Peneau S, Verdot C, Hercberg S, Touvier M. Diet and physical activity during the coronavirus disease 2019 (COVID-19) lockdown (March-May 2020): results from the French NutriNet-Sante cohort study. Am J Clin Nutr. 2021 Apr 6;113(4):924-938. doi: 10.1093/ajcn/nqaa336.
citation: Egnell M, Boutron I, Peneau S, Ducrot P, Touvier M, Galan P, Buscail C, Porcher R, Ravaud P, Hercberg S, Kesse-Guyot E, Julia C. Randomised controlled trial in an experimental online supermarket testing the effects of front-of-pack nutrition labelling on food purchasing intentions in a low-income population. BMJ Open. 2021 Feb 8;11(2):e041196. doi: 10.1136/bmjopen-2020-041196.
citation: Mervant L, Tremblay-Franco M, Jamin EL, Kesse-Guyot E, Galan P, Martin JF, Gueraud F, Debrauwer L. Osmolality-based normalization enhances statistical discrimination of untargeted metabolomic urine analysis: results from a comparative study. Metabolomics. 2021 Jan 2;17(1):2. doi: 10.1007/s11306-020-01758-z.
citation: Kesse-Guyot E, Rebouillat P, Payrastre L, Alles B, Fezeu LK, Druesne-Pecollo N, Srour B, Bao W, Touvier M, Galan P, Hercberg S, Lairon D, Baudry J. Prospective association between organic food consumption and the risk of type 2 diabetes: findings from the NutriNet-Sante cohort study. Int J Behav Nutr Phys Act. 2020 Nov 9;17(1):136. doi: 10.1186/s12966-020-01038-y.
citation: Chazelas E, Debras C, Srour B, Fezeu LK, Julia C, Hercberg S, Deschasaux M, Touvier M. Sugary Drinks, Artificially-Sweetened Beverages, and Cardiovascular Disease in the NutriNet-Sante Cohort. J Am Coll Cardiol. 2020 Nov 3;76(18):2175-2177. doi: 10.1016/j.jacc.2020.08.075. No abstract available.
citation: Debras C, Chazelas E, Srour B, Kesse-Guyot E, Julia C, Zelek L, Agaesse C, Druesne-Pecollo N, Galan P, Hercberg S, Latino-Martel P, Deschasaux M, Touvier M. Total and added sugar intakes, sugar types, and cancer risk: results from the prospective NutriNet-Sante cohort. Am J Clin Nutr. 2020 Nov 11;112(5):1267-1279. doi: 10.1093/ajcn/nqaa246.
citation: Beslay M, Srour B, Mejean C, Alles B, Fiolet T, Debras C, Chazelas E, Deschasaux M, Wendeu-Foyet MG, Hercberg S, Galan P, Monteiro CA, Deschamps V, Calixto Andrade G, Kesse-Guyot E, Julia C, Touvier M. Ultra-processed food intake in association with BMI change and risk of overweight and obesity: A prospective analysis of the French NutriNet-Sante cohort. PLoS Med. 2020 Aug 27;17(8):e1003256. doi: 10.1371/journal.pmed.1003256. eCollection 2020 Aug.
citation: Rebouillat P, Vidal R, Cravedi JP, Taupier-Letage B, Debrauwer L, Gamet-Payrastre L, Touvier M, Hercberg S, Lairon D, Baudry J, Kesse-Guyot E. Estimated dietary pesticide exposure from plant-based foods using NMF-derived profiles in a large sample of French adults. Eur J Nutr. 2021 Apr;60(3):1475-1488. doi: 10.1007/s00394-020-02344-8. Epub 2020 Jul 30.
citation: Gehring J, Touvier M, Baudry J, Julia C, Buscail C, Srour B, Hercberg S, Peneau S, Kesse-Guyot E, Alles B. Consumption of Ultra-Processed Foods by Pesco-Vegetarians, Vegetarians, and Vegans: Associations with Duration and Age at Diet Initiation. J Nutr. 2021 Jan 4;151(1):120-131. doi: 10.1093/jn/nxaa196.
citation: Partula V, Deschasaux M, Druesne-Pecollo N, Latino-Martel P, Desmetz E, Chazelas E, Kesse-Guyot E, Julia C, Fezeu LK, Galan P, Hercberg S, Mondot S, Lantz O, Quintana-Murci L, Albert ML, Duffy D; Milieu Interieur Consortium; Srour B, Touvier M. Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Sante cohort. Am J Clin Nutr. 2020 Jul 1;112(1):195-207. doi: 10.1093/ajcn/nqaa063.
citation: Chaltiel D, Julia C, Adjibade M, Touvier M, Hercberg S, Kesse-Guyot E. Adherence to the 2017 French dietary guidelines and adult weight gain: A cohort study. PLoS Med. 2019 Dec 30;16(12):e1003007. doi: 10.1371/journal.pmed.1003007. eCollection 2019 Dec.
citation: Srour B, Fezeu LK, Kesse-Guyot E, Alles B, Debras C, Druesne-Pecollo N, Chazelas E, Deschasaux M, Hercberg S, Galan P, Monteiro CA, Julia C, Touvier M. Ultraprocessed Food Consumption and Risk of Type 2 Diabetes Among Participants of the NutriNet-Sante Prospective Cohort. JAMA Intern Med. 2020 Feb 1;180(2):283-291. doi: 10.1001/jamainternmed.2019.5942.
citation: Seconda L, Egnell M, Julia C, Touvier M, Hercberg S, Pointereau P, Lairon D, Alles B, Kesse-Guyot E. Association between sustainable dietary patterns and body weight, overweight, and obesity risk in the NutriNet-Sante prospective cohort. Am J Clin Nutr. 2020 Jul 1;112(1):138-149. doi: 10.1093/ajcn/nqz259.
citation: Andrianasolo RM, Hercberg S, Kesse-Guyot E, Druesne-Pecollo N, Touvier M, Galan P, Varraso R. Association between dietary fibre intake and asthma (symptoms and control): results from the French national e-cohort NutriNet-Sante. Br J Nutr. 2019 Nov 14;122(9):1040-1051. doi: 10.1017/S0007114519001843.
citation: Chazelas E, Srour B, Desmetz E, Kesse-Guyot E, Julia C, Deschamps V, Druesne-Pecollo N, Galan P, Hercberg S, Latino-Martel P, Deschasaux M, Touvier M. Sugary drink consumption and risk of cancer: results from NutriNet-Sante prospective cohort. BMJ. 2019 Jul 10;366:l2408. doi: 10.1136/bmj.l2408.
citation: Adjibade M, Lemogne C, Touvier M, Hercberg S, Galan P, Assmann KE, Julia C, Kesse-Guyot E. The Inflammatory Potential of the Diet is Directly Associated with Incident Depressive Symptoms Among French Adults. J Nutr. 2019 Jul 1;149(7):1198-1207. doi: 10.1093/jn/nxz045.
citation: Srour B, Fezeu LK, Kesse-Guyot E, Alles B, Mejean C, Andrianasolo RM, Chazelas E, Deschasaux M, Hercberg S, Galan P, Monteiro CA, Julia C, Touvier M. Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Sante). BMJ. 2019 May 29;365:l1451. doi: 10.1136/bmj.l1451.
citation: Benard M, Bellisle F, Kesse-Guyot E, Julia C, Andreeva VA, Etile F, Reach G, Dechelotte P, Tavolacci MP, Hercberg S, Peneau S. Impulsivity is associated with food intake, snacking, and eating disorders in a general population. Am J Clin Nutr. 2019 Jan 1;109(1):117-126. doi: 10.1093/ajcn/nqy255.
citation: Mejean C, Lampure A, Si Hassen W, Gojard S, Peneau S, Hercberg S, Castetbon K. Influence of food preparation behaviors on 5-year weight change and obesity risk in a French prospective cohort. Int J Behav Nutr Phys Act. 2018 Nov 26;15(1):120. doi: 10.1186/s12966-018-0747-4.
citation: Andreeva VA, Tavolacci MP, Galan P, Ladner J, Buscail C, Peneau S, Galmiche M, Hercberg S, Dechelotte P, Julia C. Sociodemographic correlates of eating disorder subtypes among men and women in France, with a focus on age. J Epidemiol Community Health. 2019 Jan;73(1):56-64. doi: 10.1136/jech-2018-210745. Epub 2018 Oct 9.
citation: Si Hassen W, Castetbon K, Peneau S, Tichit C, Nechba A, Lampure A, Bellisle F, Hercberg S, Mejean C. Socio-economic and demographic factors associated with snacking behavior in a large sample of French adults. Int J Behav Nutr Phys Act. 2018 Mar 15;15(1):25. doi: 10.1186/s12966-018-0655-7.
citation: Si Hassen W, Castetbon K, Tichit C, Peneau S, Nechba A, Ducrot P, Lampure A, Bellisle F, Hercberg S, Mejean C. Energy, nutrient and food content of snacks in French adults. Nutr J. 2018 Feb 27;17(1):33. doi: 10.1186/s12937-018-0336-z.
citation: Fiolet T, Srour B, Sellem L, Kesse-Guyot E, Alles B, Mejean C, Deschasaux M, Fassier P, Latino-Martel P, Beslay M, Hercberg S, Lavalette C, Monteiro CA, Julia C, Touvier M. Consumption of ultra-processed foods and cancer risk: results from NutriNet-Sante prospective cohort. BMJ. 2018 Feb 14;360:k322. doi: 10.1136/bmj.k322.