louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05695053: Low Level Laser Therapy Applied in Orthodontic Tooth Movement
Official title: Low Level Laser Therapy Applied in Orthodontic Tooth Movement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Orthodontic Appliance Complication
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2023-01-23
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DEVICE_FEASIBILITY

Brief summary: Currently, orthodontic treatment takes 2-3 years.. If we accelerate tooth movement by low energy laser therapy, we could reduce treatment time. Low Level Laser Therapy(LLLT) applied in Orthodontic Tooth Movement, which stimulates formation of osteoclast-like cells expression in vitro. Osteoclast can be served as an index for tooth movement. Increasing the number of osteoclast will increase bone formation and tooth movement. We plan to find a useful clinical protocol to improve the efficiency of orthodontic tooth movement. Test low energy laser in vitro. Find an effective wavelength and irradiation time to stimulate formation of osteoclast. Develop an useful protocol that clinical orthodontist could follow and reduce orthodontic treatment time.


Eligibility criteria: Inclusion Criteria:

* Patients with good oral hygiene
* 18 years old
* Patients who required bilateral canine retraction into the extracted premolar

Exclusion Criteria:

* Serious medical history
* Poor oral hygiene
* Previous orthodontic treatment
* Orthognathic surgery or syndromic patients

Primary outcomes:
measure: Orthodontic tooth movement
timeFrame: 1-6month
Secondary outcomes:
measure: bone density after Orthodontic tooth movement
timeFrame: 1-6month
Other outcomes:
Locations:
city: Taichung City
country: Taiwan
facility: China Medical University Hospital
Study officials:
affiliation: China Medical University Hospital
name: SHENG-FEN HUANG
role: STUDY_CHAIR
References:
citation: Farivar S, Malekshahabi T, Shiari R. Biological effects of low level laser therapy. J Lasers Med Sci. 2014 Spring;5(2):58-62.
Clinical trial NCT04612153: Musculoskeletal Disorders of Workers in a Production and Distribution Company in Argentina
Official title: Musculoskeletal Disorders of Workers in a Production and Distribution Company in Argentina: a Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Describe Musculoskeletal Disorders of Workers
Lead sponsor: Ergosol
Sponsor class: INDUSTRY
First posted: 2020-11-02
Enrollment: 300
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Workers with pain

Brief summary: Describe musculoskeletal disorders of workers in a company in Argentina regarding working areas and demographic carachteristics of the workers.

Detailed description: We are analyzing the first consultation registration of every worker that had been attended by the physiotherapist in a clinic that is located inside the company. These records consist on demographic data and also injury related information.

Eligibility criteria: Inclusion Criteria:

* workers in a production and distribution company in Argentina that walks into the clinic inside the company

Exclusion Criteria:

* lack of registered information

Primary outcomes:
measure: Musculoskeletal disorders
timeFrame: 21 months
Secondary outcomes:
Other outcomes:
Locations:
city: Buenos Aires
country: Argentina
facility: Ergosol
state: Caba
Study officials:
affiliation: Ergosol
name: Diego H Mendez, PT
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06074653: Effects of Mulligans BLR and CR on Hamstrings Flexibility in Office Workers
Official title: Comparative Effects of Mulligan Bent Leg Raise and Contract Relax Technique on Hamstring Flexibility in Office Workers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Tightness
Keywords: hamstring tightness
contract relax
mulligan bent leg raise
office worker
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-10-10
Enrollment: 52
Sex: ALL
Minimum age (years): 30
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this research is to compare the effect of mulligan bent leg raise and contract relax technique on hamstring flexibility in office workers with sedentary life styles.

Detailed description: Flexibility is regarded as a crucial component of typical biomechanical operation. A tight hamstring increases the risk of frequent impairment to the associated musculature and bony structure. Hamstring muscles are associated with lumbar spine, pelvic and lower limb movement disorders and have been connected to low back discomfort and abnormal gait pattern. It has been observed that long sitting and sedentary life style is directly related to reduce the hamstrings flexibility, so the persons with tight hamstrings are more prone to develop musculoskeletal disorders if not addressed properly. Previous research has shown that contract relaxation and Mulligan's bent leg are both useful for increasing hamstring flexibility. But there hasn't been much research comparing the two methods, Mulligan bent leg lift and contract relax, for hamstring muscle stiffness in middle age office employees; instead, it was done in young people and athletes. Hence, the aim of present work is to study and compare the effectiveness of contract relax and Mulligan bent leg raise in middle age office workers with long sitting hours having hamstring tightness

Eligibility criteria: Inclusion Criteria:

* Middle age men and women (30 to 45 years)
* Working/ sitting hours ≥ 36 hours per week.
* Real estate and IT office workers.
* Participant with positive Active Knee Extension Test: A lag of 20degrees is considered normal from full extension, anything less than 20degrees is considered as hamstrings tightness

Exclusion Criteria:

* History of knee and hip injury
* Neurological impairment
* Other orthopedic conditions i.e., hip fracture, THR, TKR etc
* Fracture of lower limb

Primary outcomes:
measure: Active Knee Extension Test
timeFrame: 4 weeks
measure: Lower Extremity Functional Mobility Scale
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Bari Builders and IT path limited
state: Punjab
Study officials:
affiliation: Riphah International University
name: Faiza Ashraf, TDPT
role: PRINCIPAL_INVESTIGATOR
affiliation: Riphah International University
name: Amna Pervaiz, MS OMPT*
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00908453: The Study of NPC-06 - Investigation of Safety, Efficacy and Pharmacokinetics of Fosphenytoin
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Epilepsy
Keywords: NPC-06
fosphenytoin
phenytoin
pharmacokinetics
safety
Lead sponsor: Nobelpharma
Sponsor class: INDUSTRY
First posted: 2009-05-25
Enrollment: 40
Sex: ALL
Minimum age (years): 2
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The study is to evaluate safety, efficacy and pharmacokinetics of intravenously administered fosphenytoin in patients with neurosurgery, head trauma, epilepsy or status epilepticus who are requiring a loading dose of phenytoin.


Eligibility criteria: Inclusion Criteria:

* male or female, hospitalized patients 2 years of age or older
* Adult patients or guardian for pediatric patients to provide written informed consent

Exclusion Criteria:

* patient with a history of hypersensitivity to hydantoins
* patient with hypotension, sinus bradycardia, sino-atrial block, second or third degree A-V block, or Adams-Stokes syndrome
* pregnant or nursing female patients

Primary outcomes:
measure: Incidence of adverse events
timeFrame: 8 to 12 days
Secondary outcomes:
measure: frequency and nature of seizures
timeFrame: 8 to 12 days
Other outcomes:
Locations:
city: Kodaira
country: Japan
facility: National Center of Neurology and Psychiatry
state: Tokyo
Study officials:
affiliation: National Center of Neurology and Psychiatry
name: Eiji Nakagawa, M.D.
role: STUDY_DIRECTOR
References:
Clinical trial NCT05786053: Correction of V-pattern Strabismus by Graded Recession of Inferior Oblique Muscle .
Official title: Evaluation of Graded Recession of Inferior Oblique Muscle for Correction of Different Grades of V-pattern Strabismus
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: V Pattern Esotropia
Monocular Exotropia With V Pattern
Keywords: Vpattern strabismus
inferior oblique overaction
graded recession
Dissociated vertical deviation
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2023-03-27
Enrollment: 40
Sex: ALL
Minimum age (years): 3
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Forty patients from 3 to 18 years old with V pattern strabismus and primary IOOA were evaluated by prism cover test to assess the grade of IOOA and amplitude of V-pattern. Graded recession of IO muscle depends on the amplitude of the V-pattern and degree of IOOA. Eight mm recession for amplitude 7.5to 10 degree and mild IOOA (10 degree or +1) ,10 mm recession for amplitude 11- 15 degree and moderate IOOA (11 -15 degree or +2) and maximum recession for amplitude more than 15 degree and marked IOOA (15 or +3). Simultaneous correction of the horizontal deviation was performed at the same sitting. Follow up after one week,1 month ,3 month and 6-month.
Primary purpose: TREATMENT

Brief summary: V pattern strabismus is the commonest of alphabet pattern. Its identification is essential to plan a proper surgical management. Graded recession is a very logical approach to treat inferior oblique overaction (IOOA). The aim Is to evaluate the efficacy of graded recession of inferior oblique muscle for correction of different grades of V pattern.

Detailed description: prospective interventional study for forty patients with V pattern strabismus and primary inferior oblique overeaction will be evaluated by prism cover test to assess the grade of IOOA and amplitude of V-pattern. Graded recession of IO muscle depends on the amplitude of the V-pattern and degree of IOOA. Eight mm recession for amplitude 7.5 to 10 degree and mild IOOA (10 or +1) ,10 mm recession for amplitude 11- 15 degree and moderate IOOA (11-15 or +2) and maximum recession for amplitude more than 15 degree and marked IOOA ( more than 15 degree or +3). Simultaneous correction of the horizontal deviation will be performed at the same sitting. Follow up after I week,1 month ,3 month and 6-month.

Eligibility criteria: Inclusion Criteria:

* Cases with V pattern strabismus with the age of the patients will be ≥3 years.

Exclusion Criteria:

* - Structural ocular pathology
* Significant neurodevelopmental delay

Primary outcomes:
measure: orthotropia in primary position with no v pattern esotropia or exotropia.
timeFrame: 6 month
Secondary outcomes:
measure: No Inferior oblique overaction
timeFrame: 6 month
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Faculty of medicine
state: El Gharbeya
city: Tanta
country: Egypt
facility: Faculty of medicine
state: ELGharbia
Study officials:
References:
Clinical trial NCT02239653: Reduction of Excessive Calories From Beverages in Children
Official title: Randomized Controlled Trial to Reduce Calorie Intake From Sugar-sweetened Beverages by Children 1 - 12 Years of Age
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Unhealthy Diet
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2014-09-15
Enrollment: 443
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objective: to test the hypothesis that an intervention comprised of targeted physician and print messages can influence parents to reduce the amount of sugar-sweetened beverages (SSB) and fruit juice they give to their children 1 - 12 years of age.

Detailed description: The study will be conducted through a practice-based research network of community pediatric practices. Participating sites will be randomized to the intervention or control condition (usual care) using a pre-specified randomization scheme derived using computer generated random numbers. The intervention sites will participate in a 30-minute training for using the "Milk. Water. Period" intervention (brochures, posters, key talking points and phone messages) in their office. The goal is for them to discuss beverage consumption and encourage "Milk. Water. Period" for all children 12 months to 12 years old (not yet reached their 13th birthday) at their checkup visit. The primary care provider (PCP) will use the talking points to facilitate the discussion about drink milk and water only and will give a brochure to each family. Assessments will be by telephone interview of the parent 2 to 4 weeks after a check-up visit for the index child.

Eligibility criteria: Inclusion Criteria:

* Parent of child age 12 months to 12 years attending for a check-up visit during the study period

Exclusion Criteria:

* Cannot speak English
* No phone access
* Already completed the survey for another child.

Primary outcomes:
measure: Excessive calories from beverages
timeFrame: 2-4 weeks after check-up visit
Secondary outcomes:
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
Study officials:
References:
Clinical trial NCT00679653: Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives
Official title: Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Obesity
Hypertension
Lead sponsor: Abbott
Sponsor class: INDUSTRY
First posted: 2008-05-19
Enrollment: 171
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To study the effect of sibutramine treatment on weight reduction and blood pressure improvement in three groups with antihypertensive therapy whose blood pressure was not adequately controlled with antihypertensive combination treatment.


Eligibility criteria: Inclusion Criteria:

* Treated essential hypertension.
* Obesity: BMI 27-35 kg/m2

Exclusion Criteria:

* Secondary hypertension.
* Stage 3 hypertension.
* Secondary obesity; BMI \> 35kg/m2.
* CAD; MI within past 6 months; NYHA stage 3 or 4 heart failure; tachyarrhythmia/atrial fibrillation; myocarditis.
* Kidney failure.
* Liver failure.
* Hyperthyroidism.
* Unstable DM.
* Carcinoma.
* Severe chronic infectious disease.
* Alcohol or drug abuse.
* Pregnancy.
* Epilepsy.
* Psychosis or treatment with antidepressants or major tranquilizers

Primary outcomes:
measure: Systolic Blood Pressure
timeFrame: Duration of Study
measure: Diastolic Blood Pressure
timeFrame: Duration of Study
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01494753: Pharmacokinetics, Efficacy and Safety Assessment of T2345 Compared With Active Comparator in Newly Diagnosed Patients With Open-angle Glaucoma or Ocular Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Primary Open Angle Glaucoma
Lead sponsor: Laboratoires Thea
Sponsor class: INDUSTRY
First posted: 2011-12-19
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the pharmacokinetics, efficacy and safety of T2345 versus an active comparator.


Eligibility criteria: Inclusion Criteria:

* Untreated bilateral newly diagnosed patients with primary open angle glaucoma

Exclusion Criteria:

* Any ocular hypertension other than chronic open angle glaucoma

Primary outcomes:
measure: Mean Intra Ocular Pressure (IOP) at 8.00am
timeFrame: Day 42 and Day 84 (8.00am for the IOP)
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Aptel F, Choudhry R, Stalmans I. Preservative-free versus preserved latanoprost eye drops in patients with open-angle glaucoma or ocular hypertension. Curr Med Res Opin. 2016 Aug;32(8):1457-63. doi: 10.1080/03007995.2016.1202818. Epub 2016 Jun 25.
Clinical trial NCT06103253: Effect of Probiotic on the Gut Microbiota of Healthy Volunteers
Official title: Effect of Intervention With Probiotic on the Gut Microbiota of Healthy Volunteers: a Placebo-controlled Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Adults
Keywords: Probiotics
Gut microbiota
Uric acid
Lead sponsor: Wecare Probiotics Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2023-10-26
Enrollment: 112
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this placebo-controlled randomized trial is to test the effect of intervention with Bifidobacterium animalis subsp. lactis BLa80 on the composition of the gut microbiota of healthy volunteers. The main question it aims to answer is whether probiotic can effectively regulate intestinal flora. Participants will take a package of probiotics every day, and their weight was recorded once a week using a weight scale. Blood and stool tests were conducted before and after taking probiotics.

Detailed description: This placebo-controlled study aims to investigate the effect of Bifidobacterium animalis subsp. lactis BLa80 supplementation on the status of the gut microbiota of healthy participants. 112 subjects were randomly divided into a placebo group (maltodextrin) and a Bla80 group (maltodextrin + strain BLa80 in 1 × 10 10 colony-forming units/day). The intervention lasted 8 weeks, and 16S rRNA sequencing technology was used to study the changes in gut microbiota between different groups. Simultaneously, clinical indicators such as alanine transaminase (ALT), aspartate aminotransferase (AST), and uric acid (UC) were measured to illustrate the metabolic effects of BLa80.

Eligibility criteria: Inclusion Criteria:

* BMI ≥ 21

Exclusion Criteria:

* Those who have been diagnosed with diabetes or have high blood sugar are not recommended to participate in the test;
* People whose daily diet is too light or too greasy are not recommended to participate in the test; People with special dietary structure caused by weight loss or other reasons (such as ketogenic diet, etc.) are not recommended to participate in the test;
* Other people with special circumstances are not recommended to participate, such as those who are allergic to probiotic products; Pregnant women, breastfeeding women and people under 19 years old and over 45 years old should not be tested.

Primary outcomes:
measure: gut microbiota diversity
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Zhengzhou
country: China
facility: National Engineering Laboratory for Deep Processing of wheat and corn
state: Henan
Study officials:
References:
Clinical trial NCT02216253: L-methionine, Hibiscus Sabdariffa and Boswellia Leaf Extract to Prevent Postoperative Urinary Tract Infection.
Official title: L-methionine, Hibiscus Sabdariffa and Boswellia Leaf Extract to Prevent Postoperative Urinary Tract Infection: a Double-blind Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Urinary Tract Infection
Pelvic Organ Prolapse
Urinary Incontinence
Keywords: Urinary tract infection
Pelvic organ prolapse
Urinary incontinence
Stress urinary incontinence
Mixed Urinary incontinence
L-methionine
Placebo
Lead sponsor: IRCCS San Raffaele
Sponsor class: OTHER
First posted: 2014-08-13
Enrollment: 150
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will include women who will undergo pelvic reconstructive surgery and/or anti-incontinence sling procedures. Patients will be randomized to the combination of L-methionine, Hibiscus Sabdariffa and Boswellia Leaf Extract in tablet or placebo twice a day during the seven days before and after surgery (total of 14 days). In this randomized, double-blind study, the investigators will assess treatment of clinically suspected or culture-proven urinary tract infections within 3 weeks of surgery (primary outcome), and risk factors for treatment for postoperative urinary tract infections (secondary outcomes) between the two study groups.


Eligibility criteria: Inclusion Criteria:

* postoperative transurethral catheterization after surgery for pelvic organ prolapse and/or urinary incontinence
* patients aged ≥ 18 years

Exclusion Criteria:

* acute urinary tract infection at the moment of inclusion in the study
* antibiotic treatment prescribed for any other cause than urinary tract infection
* pregnancy
* known allergy to one of the elements of the active compound
* surgery for mesh excision
* surgery for urethral diverticulum
* surgery for fistula repair
* surgery for sacral neuromodulation
* any condition precluding the acquisition of written consent

Primary outcomes:
measure: Treatment for urinary tract infection after surgery.
timeFrame: 3 weeks after surgery.
Secondary outcomes:
Other outcomes:
Locations:
city: Milan
country: Italy
facility: IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University
state: Lombardy
Study officials:
affiliation: IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University
name: Umberto Leone Roberti Maggiore, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University
name: Stefano Salvatore, MD
role: STUDY_DIRECTOR
References: