Clinical trial NCT06843512: Identifying Changes in Food Behaviors Associated With Beginning GLP-1 Medication
Official title: Exploring the Influence of GLP-1 Medication on Food Attitudes and Selection in a Virtual Reality Buffet
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Weight Loss
Food Selection
Keywords: GLP-1
Weight Loss
Virtual Reality
Food behavior
Lead sponsor: Penn State University
Sponsor class: OTHER
First posted: 2025-02-25
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants will be identified from a list of medical patients prescribed GLP-1 medication by their physicians (located in offices near State College or Hershey, PA) and who volunteered to be contacted regarding studies they are eligible for.

Brief summary: In recent years, GLP-1 medications have become a widely employed approach by physicians to address weight concerns in patients and lead to weight loss. Little is known, however, about how these medications may alter an individual's attitude towards food, food reactivity, or the specific types and amounts of foods an individual will choose. The purpose of this study is to observe the changes an individual experiences in their relationship and reaction to food and in their food selection prior to or within the first two weeks of taking GLP-1 medication to after three months on the medication. The researchers of this study believe that an understanding of such changes can inform questions seeking to ensure maintenance of appropriate nutrient balance within individuals on weight loss medications.


Eligibility criteria: Inclusion Criteria:

* Adults (18+) with overweight or obesity (BMI \>25 kg/m2)
* Not currently taking an incretin-based medication at baseline
* Recently (within two weeks) prescribed a GLP-1, can be included if they have a obesity-related co-occurring condition (diabetes, hypertension, cardiovascular disease, dyslipidemia)
* Have had no prior diagnosis of cognitive or physical disability, dyslexia, or epilepsy.
* Fluent in English

Exclusion Criteria:

* Adults (18+) without overweight or obesity
* \<18 years of age at time of testing
* Adults not taking a GLP-1 Medication
* Adults taking a compound GLP-1
* Adults on GLP-1 medication for longer than 2 weeks at baseline
* Have had a prior diagnosis of cognitive or physical disability, dyslexia, or epilepsy.
* Not fluent in English

Primary outcomes:
measure: Change from Baseline in Total Weight of Food Selected in the VR Buffet at 3 Months
timeFrame: Baseline and 3 months
measure: Change from Baseline in Total Calories of Food Selected in the VR Buffet at 3 Months
timeFrame: Baseline and 3 months
measure: Change from Baseline in Energy Density of Food Selected in the VR Buffet at 3 Months
timeFrame: Baseline and 3 months
measure: Change from Baseline in Variety of Food Selected in the VR Buffet at 3 Months
timeFrame: Baseline and 3 months
Secondary outcomes:
measure: Change in Baseline Weight Watchers Food Noise Score at 3 Months
timeFrame: Baseline and 3 months
measure: Change in Baseline 9-question External Food Cue Responsiveness Questionnaire Score at 3 Months
timeFrame: Baseline and 3 months
measure: Change in Baseline Adult Eating Behavior Score at 3 Months
timeFrame: Baseline and 3 months
measure: Change in Baseline Three-Factor Eating Questionnaire Score at 3 Months
timeFrame: Baseline and 3 months
measure: Change in Baseline General Food Craving-Trait Scale Score at 3 Months
timeFrame: Baseline and 3 months
measure: Change in Baseline Buffet Food Liking Scores at 3 Months
timeFrame: Baseline and 3 months
Other outcomes:
measure: Change in Baseline BMI at 3 Months
timeFrame: Baseline and 3 months
Locations:
city: State College
country: United States
facility: Health, Ingestive Behavior, and Technology Laboratory of Pennsylvania State University
state: Pennsylvania
Study officials:
affiliation: The Pennsylvania State University
name: Travis Masterson
role: PRINCIPAL_INVESTIGATOR
References: