Clinical trial NCT03650322: Effects of Yoga, Strength Training and Aerobic Exercise on Cognition in Adult Cancer Survivors
Official title: Effects of Yoga, Strength Training and Aerobic Exercise on Cognition in Adult Cancer Survivors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cancer
Cancer-related Problem/Condition
Exercise
Lead sponsor: University of Illinois at Urbana-Champaign
Sponsor class: OTHER
First posted: 2018-08-28
Enrollment: 78
Sex: ALL
Minimum age (years): 30
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The investigators propose to compare the effects of a 12-week, supervised, site-based group yoga intervention on cognitive function, functional fitness, and well-being in middle-aged cancer survivors. Subjects will be randomly assigned to one of three exercise conditions: a yoga group, an aerobic walking group or a strength training group. All sessions (2-3 times per week) will be led by a trained exercise leader for a total of 150 minutes of exercise each week for the 12-week intervention.


Eligibility criteria: Inclusion Criteria:

* 30-70 years of age
* Cancer diagnosis
* 1 year since last cancer treatment (surgery, chemotherapy, and/or radiation)
* Not planning to receive treatment during study period
* Completion of Physical Activity Readiness Questionnaire (PAR-Q)
* Ambulatory and absence of health conditions that may be exacerbated by yoga, walking, or strength training
* Physician consent (if deemed necessary)
* Low-active, i.e. less than 150 minutes/week of moderate to vigorous exercise, no current yoga practice (including within last six months)
* Intention to remain in the Champaign-Urbana area over the study duration
* Willingness to be randomly assigned to one of the three groups (yoga, aerobic walking, strength training)
* Comfortable with reading, writing, and speaking English

Exclusion Criteria:

* Below 30 or above 70 years of age
* Cancer diagnosis of the brain
* Less than 1 year since last treatment (surgery, chemotherapy, and/or radiation) or plans to receive treatment during study
* Determined ambulatory or 'high risk' based on responses to PAR-Q
* High-active (exercising more than 150 minutes/week in the last six months)
* No consent from physician
* Intent to be away from the Champaign-Urbana area for an extended period of time during the study
* Inability to communicate effectively in English

Primary outcomes:
measure: Cognitive Function
timeFrame: Change from baseline to 12 weeks will be reported
Secondary outcomes:
measure: Cardiovascular Function
timeFrame: Change from baseline to 12 weeks will be reported
Other outcomes:
measure: Feasibility: Recruitment and retention rates
timeFrame: Baseline to 12-weeks
Locations:
city: Urbana
country: United States
facility: University of Illinois at Urbana-Champaign
state: Illinois
Study officials:
affiliation: University of Illinois at Urbana-Champaign
name: Neha Gothe, Ph.D., M.A.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gothe NP, Erlenbach ED, Streeter SL, Lehovec L. Effects of yoga, aerobic, and stretching and toning exercises on cognition in adult cancer survivors: protocol of the STAY Fit pilot randomized controlled trial. Trials. 2020 Sep 15;21(1):792. doi: 10.1186/s13063-020-04723-2.