Clinical trial NCT03975751: Practice of Sedation and Analgesia in Patients With Severe Brain Injury in China
Official title: A Survey on the Practice of Sedation and Analgesia Among Patients With Severe Brain Injury in China: a Prospective Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intensive Care Unit
Keywords: severe brain injuries
sedation and analgesia
intensive care unit
survey
Lead sponsor: Capital Medical University
Sponsor class: OTHER
First posted: 2019-06-05
Enrollment: 387
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All the patients at 9am on the on-site investigation day in the participating ICUs will be screened and enrolled according to the inclusion and exclusion criteria.

Brief summary: Sedation and analgesia is necessary management for patients in the intensive care units. The high-level studies of sedation and analgesia in China are still deficient, especially in patients with brain injuries who even have been excluded from the relevant studies.

Detailed description: Sedation and analgesia is necessary management for patients in the intensive care units. The high-level studies of sedation and analgesia in China are still deficient, especially in patients with brain injuries who even have been excluded from the relevant studies. In the present study, a multicenter, 1-day point cross-sectional study about the sedation and analgesia among patients in China, particularly brain-injured will be investigated. The objectives are to investigate sedation and analgesia among patients in China and to compare sedation and analgesia between brain injuries and other patients.

Eligibility criteria: Inclusion Criteria:

* All adult patients admitted to the participating ICUs on the investigation day

Exclusion Criteria:

* Age under 18 years
* Less than 24 hours of ICU stay before screening
* Taking part in other studies

Primary outcomes:
measure: Performance of sedation assessment
timeFrame: The previous 24 hours prior to the on-site investigation
measure: Performance of pain assessment
timeFrame: The previous 24 hours prior to the on-site investigation
Secondary outcomes:
measure: Use of sedatives
timeFrame: The previous 24 hours prior to the on-site investigation
measure: Use of analgesics
timeFrame: The previous 24 hours prior to the on-site investigation
measure: ICU mortality
timeFrame: Within 60 days after on-site investigation
measure: Hospital mortality
timeFrame: Within 60 days after on-site investigation
Other outcomes:
Locations:
city: Beijing
country: China
facility: ICU, Beijing Tiantan Hospital, Capital Medical University
state: Beijing
Study officials:
affiliation: Beijing Tiantan Hospital
name: Jian-Xin Zhou, MD
role: STUDY_CHAIR
References:
citation: Chen K, Yang YL, Li HL, Xiao D, Wang Y, Zhang L, Zhou JX. A gap existed between physicians' perceptions and performance of pain, agitation-sedation and delirium assessments in Chinese intensive care units. BMC Anesthesiol. 2021 Feb 25;21(1):61. doi: 10.1186/s12871-021-01286-w.