Clinical trial NCT02916277: Endocan in Ventilator-associated Pneumonia
Official title: Endocan; Can be a New Biomarker in Ventilator-associated Pneumonia?
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Serial Endocan Measurements
Lead sponsor: Erzincan University
Sponsor class: OTHER
First posted: 2016-09-27
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients whether intubated and connected to a mechanical ventilator

Brief summary: In this study; in patients undergoing mechanical ventilation, making the day series Endocan measurements during the first 5 day to look at whether there is a relationship between the levels of VAP with Endocan. This relationship, if any, aimed to investigate whether correlated with clinical and laboratory findings \[presence of fever, pathological lung X-ray, the number of white blood cells (WBC), procalcitonin (PCT), C-reactive protein (CRP)\] .


Eligibility criteria: Inclusion Criteria:

* over 18 age
* Patients whether intubated and connected to a mechanical ventilator

Exclusion Criteria:

* patients intubated due to lung problems such as COPD, asthma, pulmonary embolism , etc.
* Patients with brain tumors
* patients with acute and chronic renal failure
* Patients with hypertension
* Patients with previously diagnosed infection
* Patients with extubated
* patients using antibiotics or corticosteroids before bronchoalveolar lavage fluid samples taken

Primary outcomes:
measure: relationship between the level of Endocan and development of VAP
timeFrame: 9 month
Secondary outcomes:
measure: correlation with the level of Endocan and clinical and laboratory findings
timeFrame: 9 month
Other outcomes:
Locations:
city: Erzincan
country: Turkey
facility: Erzincan University
Study officials:
References:
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citation: Tang L, Zhao Y, Wang D, Deng W, Li C, Li Q, Huang S, Shu C. Endocan levels in peripheral blood predict outcomes of acute respiratory distress syndrome. Mediators Inflamm. 2014;2014:625180. doi: 10.1155/2014/625180. Epub 2014 Jul 16.
citation: Kupeli I, Salcan S, Kuzucu M, Kuyrukluyildiz U. Can endocan be a new biomarker in ventilator-associated pneumonia? Kaohsiung J Med Sci. 2018 Dec;34(12):689-694. doi: 10.1016/j.kjms.2018.07.002. Epub 2018 Aug 9.