Clinical trial NCT05210335: RISK ANALYSIS AND MANAGEMENT FOR MEDICATION OPTIMIZATION IN THE PREOPERATIVE AND POSTOPERATIVE PERIOD OF CARDIAC SURGICAL PATIENTS
Official title: RISK ANALYSIS AND MANAGEMENT FOR MEDICATION OPTIMIZATION IN THE PREOPERATIVE AND POSTOPERATIVE PERIOD OF CARDIAC SURGICAL PATIENTS
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Drug Related Problems
Clinical Pharmacy
Cardiac Surgery
Risk Assesment
Keywords: Drug related problems
Clinical pharmacy
Cardiac surgery
Risk assesment
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2022-01-27
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: PREVENTION

Brief summary: Optimal perioperative and long-term success in cardiac-surgery require precise management of drug treatment. This study was aimed to determine prevalence, types and associated factors of drug related problems (DRPs) at both preoperative and postoperative stages in patients at cardiac-surgery by using risk analysis method.

Detailed description: Cardiac surgery becomes a life-saving option in patients once medical treatments become inadequate. In order to achieve optimal perioperative and long- term success in cardiac surgery, drug treatment should be managed precisely. Patients with cardiovascular diseases are at risk for developing drug related problems (DRPs) due to polypharmacy and having received high-alert medications, such as antiarrhythmics or antithrombotic agents. In addition, type of operation (multiple artery bypass or combined valve procedures), existence of chronic atherosclerotic diseases (such as diabetes mellitus, hypertension), length of stay (LOS) at hospital, frailty, changes in medications for unstable cardiac conditions, incomplete or inadequate history for medication at hospital admission, transition between wards by different healthcare teams and transfer of discrepancies throughout entire perioperative period contributes to increased risk of DRPs in patients at cardiac surgery. It has been shown that over one third of patients suffer from DRPs during hospitalization. Clinical pharmacists are in a position to identify and prevent DRPs, therefore can help to provide optimal pharmaceutical treatment by performing medication reconciliation, improving patient compliance, monitoring of laboratory values and conducting patient education for surgical patients.However, there is limited information about prevalence and risk factors of DRPs in patients at cardiac surgery, in particular with perioperative stages. Majority of studies regarding DRPs have been conducted in specific populations such as elderly, pediatrics or in general medicine. Therefore this study was aimed to determine prevalence, types and associated factors of drug related problems (DRPs) at both preoperative and postoperative stages in patients at cardiac-surgery by using risk analysis method.

Eligibility criteria: Inclusion Criteria:

* Patients are aged 18 years or older
* admitted to the hospital for a planned elective cardiac surgery during the study period were considered eligible.

Exclusion Criteria:

* Patients who refused to participate,
* transferred from different wards
* have urgent surgery planned were excluded

Primary outcomes:
measure: Obtaining drug related problems preoperative and postoperative periods
timeFrame: 6 months (1 November 2019-30 March 2020)
measure: Building risk analysis model
timeFrame: 3 months (30 March 2020-30 June 2020)
measure: Obtaining clinical pharmacist affect
timeFrame: 6 months (1 August 2020- 30 January 2021)
Secondary outcomes:
measure: Obtaining clinical pharmacist intervention on other factors
timeFrame: 6 months (1 August 2020- 30 January 2021)
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University Faculty of Pharmacy Department of Clinical Pharmacy
state: Altındağ
Study officials:
References: