louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06818396: Analgesic Efficacy of Fascia Iliaca Compartment Block Compared With Intrathecal Nalbuphine for Hip Surgery Under Spinal Anesthesia
Official title: Analgesic Efficacy of Fascia Iliaca Compartment Block Compared With Intrathecal Nalbuphine for Hip Surgery Under Spinal Anesthesia: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Postoperative Pain
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2025-02-10
Enrollment: 120
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: It is already known that fascia iliaca compartment block and intrathecal nalbuphine are very effective ways in postoperative pain control in patients having hip surgeries.


Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists (ASA) score (ASA I- ASA II).
* Age ≥ 21years.
* Body mass index \< 35 kg/m2

Exclusion Criteria:

* Patient's refusal.
* Known coagulopathy.
* Known peripheral neuropathy or neurological deficits.
* Known allergy to study drugs

Primary outcomes:
measure: Time to first rescue analgesia (minutes).
timeFrame: in the first 24 hours after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain-Shams University Hospitals
Study officials:
References:
Clinical trial NCT04227496: The Effect of Auditory Disturbances on Human Movement
Official title: Evaluating the Effect of Auditory Disturbances on Human Movement
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy
Pain
Lead sponsor: University College of Northern Denmark
Sponsor class: OTHER
Collaborators: name: Aalborg University
First posted: 2020-01-13
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study sets out to investigate the potential effect of auditory disturbances on human movement

Detailed description: Clinicians routinely investigate/test human movement but if/how this is effect by auditory disturbances is unclear. This study sets out to investigate the impact of auditory disturbances on human movement.

Eligibility criteria: Criteria:

Inclusion Criteria: - Healthy participants

* Pain free healthy participants
* Able to speak, read and understand Danish and English

Exclusion Criteria: - Healthy participants

* Pain from the neck, back, arm or leg during the past 6 months up to the test session
* Former surgery in neck, back, arm or leg restricting normal movement
* Current or previous chronic or recurrent pain condition
* Pregnancy
* Current or previous neurologic, musculoskeletal or mental illnesses
* Lack of ability to cooperate

Inclusion Criteria: - Pain population

* Self reported ongoing or recurring pain from neck, back, arm or leg
* Able to speak, read and understand Danish and English

Exclusion Criteria: - Neck pain population

* Current or previous chronic or recurrent pain condition
* Former surgery in neck, back, arm or leg restricting normal movement
* Pregnancy
* Current or previous neurologic, musculoskeletal (other than what is included) or mental illnesses
* Lack of ability to cooperate

Primary outcomes:
measure: Range of motion
timeFrame: During a single test session (approximately 2hours)
Secondary outcomes:
measure: Experienced pain
timeFrame: During a single test session (approximately 2hours)
measure: Experienced difficultness of performing movement
timeFrame: During a single test session (approximately 2hours)
Other outcomes:
Locations:
city: Aalborg
country: Denmark
facility: Department of Physiotherapy, University College of Northern Denmark
Study officials:
affiliation: Department of Physiotherapy, University College of Northern Denmark
name: Steffan WM Christensen, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03784196: Changes of Pain Sensitivity During Rehabilitation of Patients Suffering From Whiplash Associated Disorders
Official title: Whiplash Associated Disorders - Sensory Changes During Rehabilitation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Whiplash
Whiplash Injury
Neck Pain
Healthy
Keywords: WAD
rehabilitation
whiplash
neck pain
pain sensitivity
Lead sponsor: Universidad San Jorge
Sponsor class: OTHER
Collaborators: name: Aalborg University
First posted: 2018-12-21
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Acute WAD following a motor vehicle accident (MVA) and age- and sex-matched healthy controls.

Brief summary: This study investigates the sensory profile of people suffering from whiplash associated disorders (WAD) during rehabilitation.

Detailed description: Altered pain sensitivity is commonly reported in WAD populations when compared to a healthy control group but how/if this changes over time during rehabilitation is unclear. This study investigates the effect of 2 weeks rehabilitation protocol on pain sensitivity in a group suffering from WAD compared to a healthy control group.

Eligibility criteria: Inclusion Criteria:

WAD

* No more than 3 weeks since MVA/WAD
* WAD grade II defined by Quebec Task Force classification

Controls • Being healthy and free from any pain specific to the low back and/or in general

Exclusion Criteria:

Applies for both groups:

* Pain related to a specific pathology such as spinal stenosis, metastasis, fracture, nerve lesions or injuries to the brain etc.
* Previous painful condition (including neck pain) in the previous 6 months.
* Prior surgery in the neck or shoulder area.
* Radiculopathy.
* Multiple painful sites/areas unrelated to the neck pain.
* Operation to the spine.
* Any neurological or systemic diseases which can affect the outcome measures.
* Pregnancy.
* Lack of ability to cooperate.

Additional exclusion criteria for Controls:

• No current or previous history of on-going pain, defined as pain in the neck/shoulder region and/or elsewhere during the past 6 months.

Primary outcomes:
measure: Changes in Pressure Pain Thresholds
timeFrame: Baseline, 2 weeks, 6 months
measure: Changes in Conditioned Pain Modulation
timeFrame: Baseline, 2 weeks, 6 months
Secondary outcomes:
measure: Neck Disability Index (NDI)
timeFrame: Baseline, 2 weeks, 6 months
Other outcomes:
Locations:
city: Villanueva De Gállego
country: Spain
facility: Universidad San Jorge
state: Zaragoza
Study officials:
affiliation: Aalborg University
name: Steffan W Christensen, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03975296: QLB Versus PVB for Acute Pain and Quality of Recovery After Laparoscopic Partial Nephrectomy
Official title: Transmuscular Quadratus Lumborum Block Versus Thoracic Paravertebral Block for Acute Pain and Quality of Recovery After Laparoscopic Partial Nephrectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nerve Block, Nephrectomy, Analgesia
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2019-06-05
Enrollment: 60
Sex: ALL
Minimum age (years): 17
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This trial is a prospective, randomized, single-center, open-label, parallel-arm, blinded-analysis trial, the objective of which is to evaluate the effect of transmuscular quadratus lumborum block (TMQLB) in the pain relief and quality of recovery in laparoscopic partial nephrectomy compared with thoracic paravertebral block (TPVB).


Eligibility criteria: Inclusion Criteria:

Age 18-70 yrs American Society of Anesthesiologists physical statusⅠ-Ⅲ Undergo laparoscopic nephrectomy Informed consent

Exclusion Criteria:

A known allergy to the drugs being used Coagulopathy, on anticoagulants Analgesics intake, history of substance abuse Participating in the investigation of another experimental agent Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Primary outcomes:
measure: cumulative morphine consumption
timeFrame: within 48 postoperative hours
Secondary outcomes:
measure: The pain scores determined by the numeric rating scale (NRS, 0-10)
timeFrame: within 48 postoperative hours
measure: dermatomal distribution of sensory reduction
timeFrame: 30 min after the block
measure: quality of recovery evaluated by the self-assessment 15-item quality of recovery (QoR) scale
timeFrame: at 3 days and 5 days after the sugery
measure: postoperative length of hospital stay
timeFrame: within 2 weeks after the surgery
measure: patient satisfaction with anesthesia
timeFrame: 48 hours after surgery
measure: nausea and vomiting episodes
timeFrame: within 24 hours after the surgery]
measure: ambulation time
timeFrame: within the 5 days after surgery
measure: time of recovery of bowl movement
timeFrame: within the 5 days after surgery
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking Union Medical College Hospital
Study officials:
affiliation: Peking Union Medical College Hospital
name: yuguang huang
role: STUDY_CHAIR
References:
Clinical trial NCT00766116: Combination 5-azacitidine and Gemtuzumab Ozogamicin Therapy for Treatment of Relapsed Acute Myeloid Leukemia (AML)
Official title: A Phase I/II Trial of the Combination 5-azacitidine and Gemtuzumab Ozogamicin Therapy for Treatment of Relapsed AML
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Acute Myeloid Leukemia
Keywords: AML
Lead sponsor: University of California, San Diego
Sponsor class: OTHER
Collaborators: name: Celgene Corporation
name: Pfizer
First posted: 2008-10-03
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: This study will test an experimental combination of the drugs Mylotarg and 5-azacitidine in the hopes of finding a treatment that may be effective against Acute Myeloid Leukemia that has come back after treatment.

Detailed description: In the Phase I portion of the study patients with a diagnosis of AML who have relapsed disease will be treated with an assigned number of doses of 5 azacitidine followed by Mylotarg administered two times over two weeks

In the Phase II portion of the study patients will be treated with the dose of 5azacitidine determined to be safe in the Phase I portion of the study followed by Mylotarg.

A sample of blood or bone marrow will be obtained prior to initiation of treatment and another sample obtained after treatment with 5-azacitidine but before Mylotarg and the samples will be tested in the laboratory to determine response to treatment.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of Relapsed AML
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2, and life expectancy \> 3 months
* ≥ 18 years old
* Previously untreated for current AML relapse
* Adequate organ function
* Written informed consent

Exclusion Criteria:

* Pregnant or breast-feeding women
* Growth factors that support platelet or white cell number or function must not have been administered within the past 7 days
* Currently receiving another investigational drug
* Currently receiving other anti-cancer agents
* Uncontrolled infection
* HIV positive
* Received previous therapy with either Mylotarg or 5-azacitidine

Primary outcomes:
measure: Number of Participants With Dose Limiting Toxicities
timeFrame: up to 28 days
Secondary outcomes:
measure: Number of Participants With Response to the Combination Treatment of Mylotarg With 5-azacitidine
timeFrame: Hematologic and Cytogeneic Response to treatment will be assessed when evaluated at the time the ANC has reached 1000/mm3 for three consecutive days, assessed up to 4 years
Other outcomes:
Locations:
city: La Jolla
country: United States
facility: UCSD Moores Cancer Center
state: California
city: Stanford
country: United States
facility: Stanford University
state: California
city: Atlanta
country: United States
facility: Northside Hospital/BMTGA
state: Georgia
Study officials:
affiliation: UCSD
name: Edward D Ball, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03865316: Comparison of Depth of Sedation Performance Between SedLine and Comparator Device During General Anesthesia
Official title: Comparison of Depth of Sedation Performance Between SedLine and Comparator Device During General Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anesthesia
Lead sponsor: Masimo Corporation
Sponsor class: INDUSTRY
First posted: 2019-03-06
Enrollment: 108
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The primary objective is to compare the performance of Masimo's SedLine and the comparator's device systems during surgery. Relative accuracy of the individual depth of sedation indices will be compared.


Eligibility criteria: Inclusion Criteria:

* Patients 18 years old and older at the time of consent.
* ASA status I, II, or III.
* English-speaking subjects.
* Scheduled for surgical and non-surgical procedures scheduled under general anesthesia (Common procedures include but are not restricted to tonsillectomy, adenoidectomy, urological procedures, dental rehabilitation, orthopedic procedures, biopsies, audiogram, nuclear scans, gastroscopy, colonoscopy, etc.).

Exclusion Criteria:

* Any deformities or devices that may prevent application of EEG Sensor to forehead with a proper fit.
* Subjects who are developmentally delayed.
* Subjects deemed not suitable for study at the discretion of the investigator.

Primary outcomes:
measure: Correlation of Sedation Indices Performance Across Anesthesia Range
timeFrame: Duration of surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Sacramento
country: United States
facility: UC Davis Medical Center
state: California
Study officials:
References:
citation: Jones JH, Nittur VR, Fleming N, Applegate RL 2nd. Simultaneous comparison of depth of sedation performance between SedLine and BIS during general anesthesia using custom passive interface hardware: study protocol for a prospective, non-blinded, non-randomized trial. BMC Anesthesiol. 2021 Apr 6;21(1):105. doi: 10.1186/s12871-021-01326-5.
Clinical trial NCT06256016: Effectiveness of Massage of the Thoracic Region in Neck Pain
Official title: Application of Massage to the Dorsal Paravertebral Muscles and Its Efficacy in the Treatment of Neck Pain
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Neck Pain
Lead sponsor: University of Alcala
Sponsor class: OTHER
First posted: 2024-02-13
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Neck pain is a common disorder in industrialized countries. Manual therapy techniques have been commonly used in the treatment of this problem. Actually, there is no research work that has evaluated the work well of treatment with soft tissue techniques (massage) applied to the dorsal paravertebral muscle in the management of neck pain. The goal of this study (clinical trial) is to compare the efficacy of a massage protocol performed on the dorsal region in subjects with mechanical neck pain.

The researchers will compare:

A group that will be treated with a local protocol of cervical manual therapy and therapeutic exercise along with the treatment(massage) of the thoracic region.

Another group that will be treated only with a local protocol of cervical manual therapy and therapeutic exercise.

It is to see if the inclusion of treatment of the thoracic region improves the local intervention in cervical region.


Eligibility criteria: Inclusion Criteria:

* Subjects with neck pain.
* Pain between 4 and 7 points according to a visual anological scale.
* Neck pain lasting more than three months

Exclusion Criteria:

* Subjects who have suffered a whiplash injury.
* Subjects with neck pain and upper extremity pain.
* Subjects with a diagnosis of herniated disc.
* Subjects with fibromyalgia.
* Subjects with any cancer process.

Primary outcomes:
measure: Neck pain
timeFrame: Change from Baseline pain at 3 month
Secondary outcomes:
measure: Neck disability index
timeFrame: Change from Baseline pain at 3 month
measure: Pain catastrophizing
timeFrame: Change from Baseline pain at 3 month
measure: kinesiophobia
timeFrame: Change from Baseline pain at 3 month
measure: The Global Rating of Change (GRoC)
timeFrame: Change from Baseline pain at 3 month
Other outcomes:
Locations:
city: Alcalá de Henares
country: Spain
facility: Physioterapy and Pain center research
state: Madrid
Study officials:
affiliation: Alcala University
name: Daniel Pecos-Martin, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02887716: Mapping the Lumbar Spine Marrow Adiposity
Official title: Mapping the Lumbar Spine Marrow Adiposity
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Marrow Adiposity Lumbar Spine
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2016-09-02
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who had an MRI of the lumbar spine in a context that justified (back pain, spondylitis research, radicular syndrome) having no corporeal spinal lesion at MRI examination.

Brief summary: The objective of this study is to describe the change in the percentage of fat in the lumbar spine.

Detailed description: The study of the distribution of bone marrow adiposity is little known in subjects who did not have pathology likely to alter the fat content of the vertebrae. Or that fat content is potentially a reflection of brittle bones (osteoporosis, for example), and deserves to be known because it can be used to normalize the lipid fraction values with respect to age or from the level (L1 , L2, L3, L4 or L5) of the vertebra being studied.

Eligibility criteria: Inclusion Criteria:

* Consecutive patients who underwent MRI of the lumbar spine with Sagittal sequenceT1, T2 STIR and IDEAL, good quality, in a clinical setting type back pain, spondylitis research, radicular syndrome ...
* Examinations conducted between 2014 and 2015 on the same equipment
* Major patient
* Having formulated their non-opposition

Exclusion Criteria:

* Previous history of neoplastic disease
* Vertebral Fracture
* Pathology reaching the vertebral body detectable by MRI (disc lesion with rearrangements of the endplates (MODIC)
* Inflammation,
* Bone tumor,
* fracture
* Refusal of participation

Primary outcomes:
measure: Value of the fat fraction by vertebral level of the lumbar spine, in MRI, measured on the mapping generated by the IDEAL-IQ sequence.
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU de Brest
Study officials:
affiliation: CHRU de Brest
name: Douraied Ben Salem, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00005416: Diet, Exercise, and Cardiovascular Health Among Ethnic Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Diseases
Heart Diseases
Lead sponsor: Augusta University
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2000-05-26
Sex: MALE
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: To analyze data collected over a four year period on an initial cohort of 3 or 4 year old children and their parents in Galveston, Texas, and in Augusta, GA, in regard to cardiovascular disease (CVD) physical risk factors and risk related behaviors.

Detailed description: BACKGROUND:

Little was known about tracking of cardiovascular disease (CVD) risk factors and risk related behaviors, or about predicting these variables in young children. Tracking was an important issue because it reflected the extent to which the disease processes found among adults start in childhood, and whether behavioral or social factors could be used to interrupt that tracking.

DESIGN NARRATIVE:

In Texas, physical risk factor data were collected at four annual clinics. Data on childrens' physical activity and diet were collected for up to four times per year for the three years between the annual measurement clinics. Similar data, although with some different measurement techniques, were collected in Georgia. For this data analysis, specific longitudinal research questions addressed whether these physical risk factors (blood pressure, lipids, lipoproteins and body composition) and risk related behaviors (diet and physical activity) tracked across the annual assessments, whether a variety of behavioral and social factors (demographic characteristics and family function) affected that tracking, and whether relationships obtained among adults between physical risk factors and these other variables could be found in this age child. The testing of these relationships was enhanced by the availability of multiple assessments of blood pressures and body composition at each point for more reliable assessments, and by multiple assessments of diet and physical activity within each year. It was further enhanced by the availability of observational data on physical activity and diet, which overcame the limitations of the more common self report approach to measurement. Models were developed in each data set and cross validated in the other. Procedures were employed to determine reasons for differences and to revise the models to produce maximal fit in both data sets. The results of these analyses contributed to a better understanding of at what age, and with what factors, it was most appropriate to intervene to mitigate CVD.

Eligibility criteria: No eligibility criteria

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: