Clinical trial NCT06764745: Effect of Different Ventilation Modes on POCD in Elderly Patients with Abdominal Wall Hernia
Official title: Effect of Different Ventilation Modes on POCD in Elderly Patients with Abdominal Wall Hernia: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Cognitive Impairment
Optic Nerve Sheath Edema
Keywords: Ventilation patterns
Elderly patients
Abdominal wall hernia
Postoperative cognitive impairment
Lead sponsor: Inner Mongolia University of Science and Technology
Sponsor class: OTHER
Collaborators: name: Inner Mongolia Baogang Hospital
name: The Affiliated Hospital of Inner Mongolia Medical University
First posted: 2025-01-08
Enrollment: 471
Sex: ALL
Minimum age (years): 65
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this clinical trial is to understand the effect of different ventilation patterns during surgery on postoperative cognitive impairment in elderly patients with abdominal wall hernias. It will also explore how to reduce the incidence of postoperative cognitive impairment. The main questions it aims to answer are:

* Does the mode of ventilation affect the incidence of postoperative cognitive impairment in elderly patients?
* Does optic nerve sheath edema affect the incidence of postoperative cognitive impairment in elderly patients? Researchers will monitor patients with different ventilation patterns intraoperatively and investigate postoperatively to see if the ventilation pattern affects postoperative cognitive impairment.

Participants will:

* Randomly assigned to groups with different ventilation patterns
* Record various values during surgery by the researchers
* Presence of cognitive impairment assessed by cognitive scales after surgery


Eligibility criteria: Inclusion Criteria:

* Age: 65-90 years
* patients with abdominal wall hernias
* American Society of Anesthesiologists general status (ASA-PS) classes II and III.

Exclusion Criteria:

* Emergency (rather than elective) surgery or other types of surgery required
* More than one surgery required during hospitalization
* Preoperative demonstrated inability to communicate (due to coma, severe dementia, Parkinson's disease, severe hearing or visual impairment, or speech impairment).

Primary outcomes:
measure: MMSE scale
timeFrame: From enrollment to two weeks after surgical treatment
measure: optic nerve sheath diameter (ONSD)
timeFrame: From induction of anesthesia to the end of surgery
measure: average airway pressure( PAWM)
timeFrame: From induction of anesthesia to the end of surgery
measure: esophagealp ressure（PES)
timeFrame: From induction of anesthesia to the end of surgery
measure: PaCO2(mmHg)
timeFrame: From induction of anesthesia to the end of surgery
measure: mean arterial pressure（MAP）
timeFrame: From induction of anesthesia to the end of surgery
measure: heart rate(HR）
timeFrame: From induction of anesthesia to the end of surgery
Secondary outcomes:
measure: Aβ1-40 (pg·mL-1)
timeFrame: From induction of anesthesia to the end of surgery
measure: S100 (pg·mL-1)
timeFrame: From induction of anesthesia to the end of surgery
measure: IL-1β (pg·mL-1)
timeFrame: From induction of anesthesia to the end of surgery
measure: IL-6 (pg·mL-1)
timeFrame: From induction of anesthesia to the end of surgery
measure: TNF-α (pg·mL-1)
timeFrame: From induction of anesthesia to the end of surgery
Other outcomes:
Locations:
city: Baotou
country: China
facility: Inner Mongolia Baosteel Hospital
state: Inner Mongolia
Study officials:
References: