Clinical trial NCT06241040: Effects of Aerobic Exercise and Core Muscle Strengthening on Pain, Menstrual Pattern and QOL in Endometriosis
Official title: Effects of Aerobic Exercise With and Without Core Muscle Strengthening on Pain, Menstrual Pattern and Quality of Life in Endometriosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Endometriosis
Keywords: Endometriosis
Menstrual pattern
Aerobic Exercise
Core Muscle Strengthening
Quality of Life
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2024-02-05
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 49
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Endometriosis is a complex and debilitating gynecological condition affecting millions of women worldwide. It is characterized by the abnormal growth of endometrial-like tissue outside the uterus, leading to chronic pelvic pain, dysmenorrhea, dyspareunia, and reduced quality of life. While pharmacological interventions are commonly prescribed to manage symptoms, their efficacy may be limited, and they often come with adverse effects. Therefore, exploring non-pharmacological approaches, such as exercise, is crucial in improving the management of endometriosis-related symptoms. Aerobic exercise has gained attention as a potential therapeutic intervention for endometriosis due to its positive effects on pain modulation, hormonal regulation, and overall well-being.

Detailed description: This randomized controlled trial (RCT) will be conducted at Jinnah Hospital in Lahore, Pakistan, to investigate the effects of aerobic exercise with and without core muscle strengthening on pain, menstrual pattern, and quality of life in women diagnosed with endometriosis. The study will employ a convenient randomization sampling technique, aiming to recruit approximately 30 participants who meet the inclusion criteria. Eligible participants will be reproductive-age women experiencing endometriosis-related pain, with regular menstrual cycles or irregularities associated with endometriosis. They should be medically stable, cleared for physical activity, and willing to participate in an exercise intervention program. Exclusion criteria include pregnancy, severe endometriosis-related complications, significant comorbidities, recent surgery, ongoing hormonal treatments targeting endometriosis, inability to participate in exercise programs, and severe mental health conditions. By investigating these interventions, the study seeks to improve symptom management, menstrual regularity, and overall quality of life for women with endometriosis while considering safety and feasibility within the study setting.

Keywords: Endometriosis, Menstrual pattern, Aerobic Exercise, Core Muscle Strengthening, Quality of Life

Eligibility criteria: Inclusion Criteria:

* Women diagnosed with endometriosis.(16)
* Age range (e.g., 18-49 years)
* Regular menstrual cycles or menstrual irregularities associated with endometriosis.
* Medically stable and cleared for participation in physical activity.
* No contraindications for aerobic exercise or core muscle strengthening

Exclusion Criteria:

* Pregnant individuals or those actively trying to conceive.
* Recent endometriosis-related surgeries/procedures
* Use of hormonal therapies/medications targeting endometriosis
* Severe endometriosis complications requiring immediate medical intervention
* Inability to engage in aerobic exercise.
* Significant cardiovascular/respiratory conditions
* Concurrent participation in another exercise/rehabilitation program

Primary outcomes:
measure: Visual Analog Scale for Pain:
timeFrame: 8 weeks
measure: Endometrial Health Profile-30 Endometrial Health Profile
timeFrame: 8 weeks
measure: Menstrual pattern Bleeding score MIQ questionnaire
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Jinnah Hospital
state: Punjab
Study officials:
affiliation: Riphah International University, Senior Lecturer
name: Faiza Taufiq, PPDPT
role: PRINCIPAL_INVESTIGATOR
References: