Clinical trial NCT00854334: Co-existent Obstructive Sleep Apnea (OSA) and Obesity: Finding Non-exercise Activity Thermogenesis (NEAT) Targets for Intervention
Official title: Co-existent OSA and Obesity: Finding NEAT Targets for Intervention
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Childhood Obesity
Childhood Obstructive Sleep Apnea
Keywords: Sleep
Overweight
Physical activity
Appetite
NEAT
Lead sponsor: Katz, Sherri Lynne, M.D.
Sponsor class: INDIV
First posted: 2009-03-03
Enrollment: 9
Sex: ALL
Minimum age (years): 10
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects will be recruited from those scheduled to undergo polysomnography in the sleep laboratory at the Children's Hospital of Eastern Ontario

Brief summary: Rationale: Obesity is an increasing childhood epidemic in Canada. Obstructive sleep apnea (OSA) is a complication of obesity which causes cardiovascular disease, reduced quality of life, and premature death. While the complex interactions between obesity and OSA are not entirely clear, we hypothesize that these conditions may compound each other by:

1. decreasing physical activity and total energy expenditure by reducing both non-exercise physical pursuits (NEAT- non-exercise activity thermogenesis) and purposeful physical activity.
2. alterations in the secretion of appetite-controlling hormones, which may lead to increases in energy intake.

Objective: To determine whether the presence of both obesity and OSA in children is associated with a decrease in physical activity and alterations in appetite-regulating hormones greater than those seen in either condition alone or compared to controls.

Methods: Comparison of children 10-17 years with obesity and OSA, obesity alone, OSA alone and neither condition, for the following outcomes: (1) NEAT (kcal/day) (2) Physical activity behavior, appetite regulating hormone profile and self-report appetite assessment.

Unique Aspects: This study combines expertise in sleep medicine, exercise physiology and obesity. Conclusions from this study will better characterize this high-risk clinical population so that innovative strategies targeting improvements in lifestyle behaviors can be developed.


Eligibility criteria: Inclusion Criteria:

* age 10-17 years
* coming for polysomnography at the Children's Hospital of Eastern Ontario

Exclusion Criteria:

* children receiving treatment for OSA with CPAP (continuous positive airway pressure) or bi-level therapy
* craniofacial abnormalities
* genetic syndromes
* neuromuscular disease
* tracheostomy
* medications that may affect appetite or energy balance (systemic corticosteroids)

Primary outcomes:
measure: NEAT (kcal/day)
timeFrame: 10 day period
Secondary outcomes:
measure: Physical activity behavior (minutes of moderate-vigorous physical activity as directly measured by accelerometry), appetite regulating hormone profile and self-report appetite assessment.
timeFrame: 10 day period
Other outcomes:
Locations:
city: Ottawa
country: Canada
facility: Childrens Hospital of Eastern Ontario
state: Ontario
Study officials:
References: