louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06861751: Correlation Between Smart Phone Overuse, Craniovertebral Angle, Cervical Muscle Endurance and Temporomandibular Proprioception in Adolescents
Official title: Correlation Between Smart Phone Overuse, Craniovertebral Angle, Cervical Muscle Endurance and Temporomandibular Proprioception in Adolescents
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Smart Phone Addiction
Craniovertebral Angle
Temporomandibular Proprioception
Adolescents
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-03-06
Enrollment: 160
Sex: ALL
Minimum age (years): 17
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: 160 adolescent from both sexes with their age ranging from 17 to 19 years and were smart phone addictors for not less than 4 years old

Brief summary: The study was done to:

1. Investigate the correlation between smart phone overuse and craniovertebral angle in adolescents.
2. Investigate the correlation between smart phone overuse and cervical muscle endurance in adolescents.
3. Investigate the correlation between smart phone overuse and temporomandibular joint proprioception in adolescents.

Detailed description: This study was aimed to clarify the correlation between prolonged use of spinal traction on cervical curvature, muscle endurance, and temporomandibular joint proprioception in adolescents. It assisted physiotherapists in detecting and treating problems caused by prolonged spinal traction use, providing necessary precautions and treatments to prevent or alleviate this issue.

Eligibility criteria: Inclusion Criteria:

1. Both genders will be included.
2. Adolescents with age ranging from 17 to 19 years.
3. Adolescents using smart phone daily for not less than 4 years for 4 years.
4. All participants will be free from any medical disease, visual or hearing problem.
5. No history of temporomandibular joint complaints or disorder.

Exclusion Criteria:

1. Adolescent who cannot understand or follow instructions.
2. Congenital or acquired spinal deformities.
3. Adolescents with obesity.
4. Athlete adolescents.
5. Any neck or upper extremity Injury.
6. Neurological, musculoskeletal, and cardiopulmonary disease.
7. Adolescent with teeth braces during last 4 years

Primary outcomes:
measure: Assessment of body mass index
timeFrame: at baseline
Secondary outcomes:
measure: Assessing the craniovertebral angle using software program
timeFrame: at baseline
measure: Testing of temporomandibular joint Proprioception
timeFrame: at baseline
measure: Measuring the Endurance of deep neck flexor muscles
timeFrame: at baseline
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: out-patient clinic, faculty of physical therapy, Delta University for Science and Technology
Study officials:
References:
Clinical trial NCT05072951: Urine Biomarker for Kidney Transplant Rejection
Official title: An Adaptive Sample Collection to Evaluate a Biomarker for Kidney Transplant Rejection
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Graft Rejection
Lead sponsor: Exosome Diagnostics, Inc.
Sponsor class: INDUSTRY
First posted: 2021-10-11
Enrollment: 750
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male and Female, at least 18 years of age with a kidney transplant prior to enrollment.

Brief summary: An adaptive sample collection to support biomarker evaluation for kidney transplant rejection.


Eligibility criteria: Inclusion Criteria:

* Ability to provide informed consent
* Kidney Transplant

Exclusion Criteria:

* Pediatric patients, under 18 years of age

Primary outcomes:
measure: Biospecimen collection
timeFrame: 3 years after last enrollment
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Exosome Diagnostics, Inc.
name: Sonia Kumar
role: STUDY_CHAIR
References:
Clinical trial NCT03680651: Frequency and Type of Genetic Abnormalities Found in Antenatal Corpus Callosum Malformation
Official title: Frequency and Type of Genetic Abnormalities Found in Antenatal Corpus Callosum Malformation
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Corpus Callosum Malformation
Prenatal Disorder
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2018-09-21
Enrollment: 275
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Fetuses with prenatal diagnosis of corpus callosum malformation and antenatal molecular analysis by array CGH performed

Brief summary: Corpus callosum malformation (CCM) is the most frequently detected cerebral defect diagnosed in the prenatal setting. The most common CCM is corpus callosum agenesis (CCA) which is found in 2 to 3% of patients presenting with intellectual disability.

When CCM is diagnosed, the risk of chromosomal disorder is estimated to be 16%, be it aneuploidy such as trisomy 18, trisomy 13 or mosaic trisomy 8, or a chromosome structure anomaly, copy number variation or more complex rearrangement In France, since 2013 oligoarray-based comparative genomic hybridization (aCGH) analysis is performed in the prenatal period for most malformations after approval by a multidisciplinary prenatal diagnosis ethics committee (Centre Pluridisciplinaire de Diagnostic Prénatal, CPDPN) . However, to date only a few studies have been published which report recurrent Copy Number Variations (CNV) associated with CCM and estimate the risk for a chromosomal disorder, thus making counseling difficult in this context of prenatal diagnosis.


Eligibility criteria: Inclusion Criteria:

* Prenatal diagnosis of corpus callosum malformation, isolated or not, between 01/01/2013, and 31/05/2018
* Fetal DNA available
* Mother's informed consent obtained

Exclusion Criteria:

* No amniocentesis performed
* Refusing to participate

Primary outcomes:
measure: frequency of chromosomal abnormalities
timeFrame: 6 months
Secondary outcomes:
measure: Type of chromosomal abnormalities
timeFrame: 6 months
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU de Brest
Study officials:
References:
Clinical trial NCT01187251: Incidence of Tinnitus Amongst Teenagers and Young Adults mp3 Users
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tinnitus
Keywords: tinnitus
mp3 players
noise induced hearing loss
high frequencies audiometry
acoustic otoemissions
Lead sponsor: Faculdade de Medicina de Valenca
Sponsor class: OTHER
First posted: 2010-08-24
Enrollment: 100
Sex: ALL
Minimum age (years): 15
Maximum age (years): 30
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: teenagers and young adults (15 to 30 years old)

Brief summary: The aim of this study is to compare the incidence of tinnitus between mp3 users and non-users, aged between 15 and 30 years old. 100 patients will be recruited in Valença secondary schools. High frequency audiometry and otoacoustic emissions will be performed.Tinnitus patients will complete the Tinnitus Handicap Inventory questionnaire.


Eligibility criteria: Inclusion Criteria:

* 15 to 30 years old
* A-n tympanogram

Exclusion Criteria:

* muscular tinnitus
* vascular tinnitus
* somatosensorial tinnitus
* concomitant TMJ disorders
* external and middle ear diseases
* professional or recreative exposure to other noise sources other than mp3 players

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Valença
country: Brazil
facility: caculdade de Medicina de Valença
state: RJ
city: Volta Redonda
country: Brazil
facility: OTOSUL,Otorrinolaringologia Sul-Fluminense
state: RJ
Study officials:
References:
Clinical trial NCT00673751: Effect of the Enteric Hormone Glucagon-Like Peptide (GLP-2) on the Intestinal Blood Flow in Patients With Short Bowel Syndrome
Official title: GLP-2 Mediated Increased SMA Blood Flow in Patients With Short Bowel Syndrome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Short Bowel Syndrome
Keywords: mesenteric blood flow
GLP-2
short bowel syndrome
Glucagon-Like Peptide 2
Lead sponsor: Glostrup University Hospital, Copenhagen
Sponsor class: OTHER
First posted: 2008-05-07
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of the study is to investigate the effect of the enteric hormone Glucagon-like Peptide (GLP-2) on patients with short bowel syndrome

Detailed description: previous studies have shown that GLP-2 increases mesenteric blow flow, we wish to examine the effect of subcutaneus GLP-2 on patients with short bowl syndrome. The patients will single blinded been given 450 nmol GLP-2 and isotonic saline in order to act as their own reference.

Eligibility criteria: Inclusion Criteria:

* clinical diagnose of short bowel syndrome 4 month of stable fase

Exclusion Criteria:

* activity in IBD

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Glostrup
country: Denmark
facility: Glostrup University Hospital
state: Region Hovedstaden
Study officials:
References:
Clinical trial NCT05628051: Carotid Artery Corrected Flow Time as a Predictor of Hypotension After Induction of General Anesthesia in Elderly Patients
Official title: Effect of Carotid Corrected Flow Time Combined With Perioperative Fluid Therapy on Preventing Hypotension After General Anesthesia Induction in Elderly Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: General Anesthesia Induction for Elective Surgery
Lead sponsor: Fujian Medical University Union Hospital
Sponsor class: OTHER
First posted: 2022-11-28
Enrollment: 177
Sex: ALL
Minimum age (years): 65
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who were scheduled to undergo elective surgery under general anesthesia

Brief summary: The number of elderly patients undergoing elective surgery has been growing in recent years. Elderly patients often have a variety of underlying diseases, including hypertension, coronary heart disease, diabetes, arteriosclerosis, etc., which increase the risk. When the elderly receive general anesthesia, hypotension often occurs after anesthesia induction. Once hypotension occurs, it may lead to myocardial ischemia, myocardial infarction, stroke and other serious complications. Therefore, in clinical anesthesia, a simple, quick and accurate prediction method is needed to evaluate and predict the risk of hypotension in elderly patients after induction, so that appropriate intervention measures can be taken in advance to reduce the incidence of hypotension in elderly patients after induction, thus reducing the occurrence of related complications and ensuring the safety of anesthesia and surgery.Carotid Artery Corrected Flow Time（FTc） is a recently developed volumetric predictor, which refers to the time between the the onset of systolic flow until the closure of the aortic valve. It is related to cardiac preload and can reflect cardiac output to a certain extent. It is considered as a reliable indicator for evaluating volume status and volumetric reactivity. Therefore, this study assessed the effect of FTc combined with perioperative fluid therapy on preventing hypotension after general anesthesia induction in elderly patients.


Eligibility criteria: Inclusion Criteria:

* patients who received elective surgery under general anesthesia, aged 65-85 years old, gender unlimited, ASAI-II

Exclusion Criteria:

* uncontrolled hypertension
* unstable angina pectoris
* history of myocardial infarction
* after heart stent implantation
* severe arrhythmia：Atrial fibrillation、Ventricular premature beat, frequent atrial premature beat, other non-sinus rhythm
* pacemaker implants
* cardiomyopathy
* a left ventricular ejection fraction of \< 40%
* history of neck trauma and surgery
* BMI\>30

Primary outcomes:
measure: Carotid artery corrected flow time (FTc)
timeFrame: 5 minutes before induction of general anesthesia
Secondary outcomes:
Other outcomes:
Locations:
city: Fuzhou
country: China
facility: Fujian Medical University Union Hospital
state: Fujian
Study officials:
References:
Clinical trial NCT01404351: Use of the PEAK PlasmaBlade 4.0 in Bilateral Breast Reduction
Official title: A Prospective, Randomized, Controlled Superiority Study to Evaluate Use of the PEAK PlasmaBlade® 4.0 in Bilateral Breast Reduction
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Macromastia (Symptomatic)
Keywords: Reduction mammaplasty
Breast reduction
PlasmaBlade
PEAK
Lead sponsor: Medtronic Surgical Technologies
Sponsor class: INDUSTRY
First posted: 2011-07-28
Enrollment: 0
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this clinical study is to evaluate the operative performance of the PEAK PlasmaBlade® 4.0 during bilateral breast reduction; to monitor and record post-operative pain, adverse events and skin scarring following surgery; and to compare these outcomes to the HARMONIC SYNERGY® BLADE.


Eligibility criteria: Inclusion Criteria:

1. Age between 18 and 70
2. Physically healthy, stable weight
3. No smoking \<1 month prior to surgery and during study.
4. Desiring bilateral breast reduction
5. Subject must understand the nature of the procedure and provide written informed consent prior to the procedure.
6. Subject must be willing and able to comply with specified follow-up evaluations.
7. Female subjects must either be incapable of reproduction, or taking acceptable measures to prevent pregnancy and have a negative pregnancy test prior to participation in the study.

Exclusion Criteria:

1. Age younger than 18 or greater than 70 years old
2. Anticoagulation therapy which cannot be discontinued
3. Smoking \<1 month prior to surgery or during study
4. Infection (local or systemic)
5. Cognitive impairment or mental illness
6. Severe cardiopulmonary deficiencies
7. Known coagulopathy
8. Immunocompromised
9. Prior history of breast cancer
10. Kidney disease (any type)
11. Currently taking any medication known to affect healing
12. Subjects who are status-post gastric banding or gastric bypass
13. Currently enrolled in another investigational device or drug trial
14. Unable to follow instructions or complete follow-up

Primary outcomes:
measure: Difference in pain
timeFrame: 24 hours and first 10 days post-op
Secondary outcomes:
measure: Operative performance
timeFrame: Intraoperatively on day 0
measure: Adverse events
timeFrame: 1 month post-operatively
measure: Cutaneous scarring
timeFrame: Up to one year post-operatively
Other outcomes:
Locations:
city: Johnstown
country: United States
facility: Gonyon Cosmetic & Plastic Surgery, PC
state: Colorado
Study officials:
affiliation: Gonyon Cosmetic & Plastic Surgery, PC
name: Denis Gonyon, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00773877: Comparison of Retinal Nerve Fiber Layer (RNFL) Thickness Measurements by Time-Domain and Spectral-Domain OCT In Glaucoma Patients
Official title: Comparison of RNFL Thickness Measurements by Time-Domain and Spectral-Domain OCT In Glaucoma Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Primary Open Angle Glaucoma
Keywords: RNFL thickness
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2008-10-16
Enrollment: 400
Sex: ALL
Minimum age (years): 10
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Primary open angle glaucoma

Brief summary: Measurement of RNFL thickness by OCT is at a cornerstone for the correct diagnosis and monitoring of progression of glaucomatous optic neuropathy.

Spectral domain technology has enabled better reproducibility with better axial resolution in the measurement of RNFL thickness. A comparative study among Stratus, Cirrus and RT-View will enable clinicians to determine differences among various instruments.


Eligibility criteria: Exclusion Criteria:

* Evidence of retinal disease
* Secondary glaucoma due to intraocular inflammation
* Lens induced glaucoma
* Neovascular glaucoma
* Tumor induced glaucoma

Primary outcomes:
measure: RNFL thickness
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University School of Medicine
Study officials:
References:
Clinical trial NCT03875677: High-definition Transcranial Direct Current Stimulation for Facilitating Hand Function Recovery After Stroke
Official title: Using Neuroimage and Computational Modeling to Customize High-definition Transcranial Direct Current Stimulation Protocols for Facilitating Hand Function Recovery After Stroke
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2019-03-15
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Transcranial direct current stimulation (tDCS) had recently been shown having feasibility in modulating cortical excitability transiently during motor training in a noninvasive way. The findings support that tDCS and motor practice can positively promote post-stroke motor learning to improve upper-limb motor recovery after stroke. A randomized controlled trial will be conducted with three groups: HD-tDCS, conventional tDCS and sham HD-tDCS. A 10-session training will be provided to evaluate the effectiveness of transient modulation of cortical excitability through tDCS with clinical assessment scores.


Eligibility criteria: Inclusion Criteria:

1. Hemiparesis subsequent to first-ever unilateral stroke for more than 6 months;
2. MCP and PIP finger joints can be extended to 180° passively;
3. Sufficient cognition to follow the experimental instructions

Exclusion Criteria:

1. Severe hand spasticity or hand deformity;
2. History of alcohol or drug abuse or epilepsy;
3. Bilateral brain infarcts;
4. Severe cognitive deficits;
5. Comprehensive aphasia;
6. Contraindications to tDCS

Primary outcomes:
measure: Action Research Arm Test (ARAT)
timeFrame: 3-month after the 10th session training
Secondary outcomes:
measure: Fugl-Meyer Assessment (Upper Extremity)
timeFrame: 3-month after the 10th session training
measure: Wolf Motor Function Test (WMFT)
timeFrame: 3-month after the 10th session training
measure: Magnetic Resonance Imaging
timeFrame: Baseline
Other outcomes:
Locations:
city: Shatin
country: Hong Kong
facility: Department of Biomedical Engineering, The Chinese University of Hong Kong
Study officials:
affiliation: Department of Biomedical Engineering, CUHK
name: Raymond Tong, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04525677: Gut Microbiome Dysbiosis in Sepsis-induced Coagulopathy
Official title: Gut Microbiome Dysbiosis in Sepsis-induced Coagulopathy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sepsis
Lead sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2020-08-25
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Department of Intensive Care Unit, Sun Yat-sen Memorial Hospital, Sun Yat-sen University

Brief summary: In the diagnosis and treatment of patients with sepsis, through routine stool testing and dynamic testing of coagulation function, we found that patients often have stools that are not formed, the proportion of main fecal bacteria is imbalanced, the level of blood bacterial toxins rises, and the abnormal coagulation status indicate the gut microbiome dysbiosis may play an important regulatory role in abnormal blood coagulation in patients with sepsis. Therefore, we propose that the gut microbiome dysbiosis is involved in sepsis-induced coagulopathy. This project intends to prospectively observe the changes in gut microbiome dysbiosis and blood coagulation function in patients with sepsis before and after treatment, and explore whether the changes in gut microbiome dysbiosis promote the development of sepsis through coagulation disorders, provide new research perspectives for diagnosis and treatment for sepsis.


Eligibility criteria: Inclusion Criteria:

* Age ≥18 years and ≤85 years
* Sign the informed consent form
* Expected ICU hospital stay\> 24 hours
* △SOFA score ≥2 and confirmed or suspected infection

Exclusion Criteria:

* Pregnant or breastfeeding women
* Estimated survival time \<24 hours
* Diagnosis of sepsis time\> 24 hours
* The length of ICU stay before diagnosis of sepsis\> 7 days
* Sepsis from which the source of infection cannot be determined
* Congenital coagulopathy

Primary outcomes:
measure: Gut Microbiome alterations
timeFrame: Day 1- Day 14
measure: coagulation disorder tests
timeFrame: Day 1- Day 14
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Sun Yat-sen Memorial Hospital, Sun Yat-sen University
state: Guangdong
Study officials:
affiliation: Department of Intensive Care Unit, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
name: minggen Zhou
role: STUDY_CHAIR
References:
Clinical trial NCT01239277: Combined Nutrient Intake and Muscle Protein Synthesis
Official title: Combined Nutrient Intake and Muscle Protein Synthesis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging
Keywords: muscle
FSR
protein
carbohydrate
leucine
Lead sponsor: Maastricht University Medical Center
Sponsor class: OTHER
First posted: 2010-11-11
Enrollment: 48
Sex: MALE
Minimum age (years): 70
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.


Eligibility criteria: Inclusion Criteria:

* males
* 70-85 years or 18-30 years
* BMI \< 30

Exclusion Criteria:

* Type II diabetes
* All co morbidities interacting with mobility and muscle metabolism of the lower limbs
* Use of anticoagulants
* Patients suffering from Phenylketonuria
* Participation in any regular exercise programme

Primary outcomes:
measure: Muscle protein synthesis
timeFrame: 6 h postprandial period
Secondary outcomes:
Other outcomes:
Locations:
city: Maastricht
country: Netherlands
facility: Universiteit Maastricht, Bewegingswetenschappen
state: Limburg
Study officials:
affiliation: Maastricht University Medical Center
name: A. de Lange
role: PRINCIPAL_INVESTIGATOR
References: