Clinical trial NCT03119740: Postoperative Complications After Appendectomy
Official title: Clinical Value of Postoperative C-reactive Protein in the Detection of Complications After Open and Laparoscopic Appendectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Appendicitis
Lead sponsor: Kepler University Hospital
Sponsor class: OTHER
First posted: 2017-04-19
Enrollment: 744
Sex: ALL
Minimum age (years): 18
Maximum age (years): 96
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who had undergone open or laparoscopic appendectomy because of clinically suspected appendicitis between 1 January 2011 and 31 December 2015 at the department of general and visceral surgery, Kepler University Hospital in Linz, Austria

Brief summary: The frequency of complications after appendectomy is about 9% . The predictive value of CRP as an indicator of postoperative complications has been addressed in a small number of studies. The aim of the present retrospective analysis was to determine whether postoperative CRP levels are a reliable predictor of postoperative complications.

Detailed description: Background: Acute appendicitis is a common emergency in general surgery. The frequency of complications after appendectomy is about 9% \[9\]. The predictive value of CRP as an indicator of postoperative complications has been addressed in a small number of studies. The aim of the present retrospective analysis was to determine whether postoperative CRP levels are a reliable predictor of postoperative complications.

Methods: This retrospective single-center cohort study comprised 744 patients who had undergone open or laparoscopic appendectomy for clinically suspected appendicitis between 1 January 2011 and 31 December 2015 at the department of general and visceral surgery, Kepler University Hospital in Linz, Austria. Demographic data, the surgical technique, postoperative complications, histopathological findings, postoperative white blood counts, and C-reactive protein levels were evaluated.

Eligibility criteria: Inclusion Criteria:

* clinically suspected appendicitis between 1 January 2011 and 31 December 2015

Exclusion Criteria:

* an elective appendectomy as part of an oncological or gynecological operation tumor was found intraoperatively and required ileocecal resection or right hemicolectomy

Primary outcomes:
measure: superficial wound infection
timeFrame: 4 weeks postoperative
Secondary outcomes:
measure: intraabdominal abscess
timeFrame: 4 weeks postoperative
measure: ileus
timeFrame: 4 weeks postoperative
Other outcomes:
Locations:
city: Linz
country: Austria
facility: Clinic for General and Visceral Surgery, Kepler University Clinic Linz
state: Upper Austria
Study officials:
affiliation: Clinic for General and Visceral Surgery, Kepler University Clinic Linz
name: Andreas Shamiyeh, MD
role: STUDY_DIRECTOR
References:
citation: Barkhausen S, Wullstein C, Gross E. [Laparoscopic versus conventional appendectomy--a comparison with reference to early postoperative complications]. Zentralbl Chir. 1998;123(7):858-62. German.
citation: Izbicki JR, Knoefel WT, Wilker DK, Mandelkow HK, Muller K, Siebeck M, Schweiberer L. Accurate diagnosis of acute appendicitis: a retrospective and prospective analysis of 686 patients. Eur J Surg. 1992 Apr;158(4):227-31.
citation: Kaya B, Sana B, Eris C, Karabulut K, Bat O, Kutanis R. The diagnostic value of D-dimer, procalcitonin and CRP in acute appendicitis. Int J Med Sci. 2012;9(10):909-15. doi: 10.7150/ijms.4733. Epub 2012 Nov 13.