Clinical trial NCT03370081: Effects of Capnometry Monitoring in Post Anesthesia Care Unit
Official title: Effects of Capnometry Monitoring in Post Anesthesia Care Unit
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: VENTILATION
Capnography
Keywords: Capnometry
Capnography
ETCO2
Recovery room
Post-anesthesia care unit
Lead sponsor: University Hospital, Bordeaux
Sponsor class: OTHER
First posted: 2017-12-12
Enrollment: 53
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: There is few information about the best capnometry value in recovery room for intubated awakening patients. Furthermore, capnometry values could influence ventilation applied by nurses on these patients. The aim of this study is to observe the effects of capnometry monitoring on intubated awakening patients in recovery room.

Detailed description: In France, there is actually no recommandation about capnography monitoring in recovery rooms. Nevertheless, some patients are still ventilated in post-anesthesia care units during awakening period. Alveolar hypoventilation could induce moderate hypercapnia, thereby stimulate central ventilatory command. However, this hypoventilation could delay the clearance of anesthetic gases. Capnometry monitoring could influence ventilation applied to these patients. Recovery rooms nurses would perform moderate hyperventilation in response to hign capnometry values. This method could enhance gases elimination, with faster spontaneous breathing recovery and extubation. Length of stay in recovery room could also be shortened. An objective surrogate of ventilation is maximal End Tidal CO2, if there is no alveolo-capillary gradient abnormality (Obesity, Chronic respiratory disease, Cyanogenic heart disease). Thus, this study will compare the percentage of patients who reached a maximum End Tidal CO2 greater than 45mmHg during awakening period in post-anesthesia care unit (PACU) in 2 groups :

* first group ("non-blind group") with capnography monitoring see by the PACU nurses
* second group ("blind group") with capnography monitoring but PACU nurses cannot see the values Other parameters like the time between ventilator's disconnection and the first ventilatory cycle in spontaneous ventilation, the time between ventilator's disconnection and tracheal extubation or laryngeal mask's withdrawal, the minimal SpO2 reached after tracheal extubation or laryngeal mask withdrawal or the length of stay in PACU are also recorded.

Eligibility criteria: Inclusion Criteria:

* Major patients with given written consent
* General anesthesia, induction with Propofol infusion and Target-Controlled Infusion (TCI) remifentanil, relayed with inhaled sevoflurane and TCI remifentanil
* Upper airway control with naso-orotracheal tube or laryngeal mask
* Ventilated normotherm patients in PACU

Exclusion Criteria:

* Minor or pregnant patients
* Obesity with Body Mass Index \> 40 kg/m²
* Chronic respiratory disease with SpO2\<90% in ambiant air
* Cyanogenic heart disease
* Patients under myorelaxant in PACU

Primary outcomes:
measure: End Tidal CO2 up
timeFrame: through awakening period in PACU, an average of 30 minutes
Secondary outcomes:
measure: End Tidal CO2 max 1
timeFrame: through awakening period in PACU, an average of 15 minutes
measure: End Tidal CO2 max 2
timeFrame: through awakening period in PACU, an average of 30 minutes
measure: respiratory rate
timeFrame: through awakening period in PACU, an average of 15 minutes
measure: spontaneous ventilation time
timeFrame: through awakening period in PACU, an average of 15 minutes
measure: time for removal of airway device
timeFrame: through awakening period in PACU, an average of 30 minutes
measure: Spo2 min
timeFrame: through awakening period in PACU, an average of 2 hours
measure: length of stay in PACU
timeFrame: through awakening period in PACU, an average of 2 hours
measure: time for oxygenotherapy removal
timeFrame: through awakening period in PACU, an average of 1 hour
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: Centre hospitalier Universitaire de Bordeaux
Study officials:
References:
citation: Potvin J, Etchebarne I, Soubiron L, Biais M, Roullet S, Nouette-Gaulain K. Effects of capnometry monitoring during recovery in the post-anaesthesia care unit: a randomized controlled trial in adults (CAPNOSSPI). J Clin Monit Comput. 2022 Apr;36(2):379-385. doi: 10.1007/s10877-021-00661-9. Epub 2021 Feb 7.