Clinical trial NCT06549322: Timing and Resistance Exercise: Impact on Eating and Metabolism
Official title: The Efficacy of Exercise Timing - Effects of Resistance Exercise on Eating Behavior and Energy Metabolism
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Circadian Rhythm
Energy Balance
Appetitive Behavior
Food Reward
Keywords: resistance exercise
energy expenditure
Lead sponsor: National Taiwan Normal University
Sponsor class: OTHER
First posted: 2024-08-12
Enrollment: 18
Sex: MALE
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Exercise timing (morning or evening) for optimal weight control is a research topic urgently addressed by scholars in the relevant field. Due to the better control of energy metabolism and physical activity levels in the morning, existing research on resistance exercise and eating behavior primarily focuses on experiments conducted in the morning, with only one study in the afternoon. No research has yet compared the potential differences between morning and evening resistance exercise. A one-year study aims to investigate the impact of morning and evening resistance exercise on physiological metabolism and eating behavior. Eighteen healthy male participants will be randomly assigned to a crossover design study, including AM exercise, PM exercise, and control (rest condition) trials. Variables including subjective appetite, appetite hormones (ghrelin, peptide YY), food preferences, ad libitum eating, dietary records, energy expenditure, and PBMCs circadian rhythm genes will be measured. This preliminary study through a multidimensional observation, the results will contribute to understanding the potential differences and mechanisms of morning and evening resistance exercise on physiological metabolism and eating behavior. In practical applications, conducting resistance exercise in the evening or at night aligns better with current lifestyles. The findings of this study can support the optimization of exercise benefits by validating the choice of exercise timing.


Eligibility criteria: Inclusion Criteria:

* Age: 20-30
* weight stable for at least 6 months

Exclusion Criteria:

* Obesity (BMI \> 30 kg/m² or body fat percentage \> 25%)
* Hypertension (blood pressure over 140/90 mmHg)
* Heart disease
* Cancer
* Liver or kidney diseases
* Any other conditions that could potentially influence the study's outcomes

Primary outcomes:
measure: Subjective appetite Subjective appetite Subjective appetite Subjective appetite Subjective appetite Subjective appetite
timeFrame: 3 hours during each study intervention
measure: Change in acyl-Ghrelin
timeFrame: 3 hours during each study intervention
measure: Change in PYY
timeFrame: 3 hours during each study intervention
measure: Change in Leptin
timeFrame: 3 hours during each study intervention
measure: Change in lactate
timeFrame: 3 hours during each study intervention
measure: Change in PBMCs circadian rhythm genes
timeFrame: 3 hours during each study intervention
measure: Energy intake
timeFrame: The Before day, the durning day, and the day following the experiment.
measure: Energy expenditure
timeFrame: The Before day, the durning day, and the day following the experiment.
Secondary outcomes:
measure: Explicit liking
timeFrame: 3 hours during each study intervention
measure: Explicit wanting
timeFrame: 3 hours during each study intervention
measure: Implicit wanting
timeFrame: 3 hours during each study intervention
measure: Relative preference
timeFrame: 3 hours during each study intervention
measure: Taste appeal bias
timeFrame: 3 hours during each study intervention
measure: Fat appeal bias
timeFrame: 3 hours during each study intervention
measure: change in Cortisol
timeFrame: 3 hours during each study intervention
measure: change in complete blood count
timeFrame: 3 hours during each study intervention
measure: change in growth hormone
timeFrame: 3 hours during each study intervention
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan Normal University
Study officials:
affiliation: National Taiwan Normal University
name: Hung-wen Liu, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: