louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02369263: DVT Ultrasound in the Emergency Department
Official title: An Observational Study of Emergency Medicine Resident Performed Ultrasonography for DVT.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Deep Vein Thrombosis
DVT
Keywords: Deep Vein Thrombosis
DVT
Leg Swelling
Leg Pain
Blood Clot
Lead sponsor: Emergency Medicine Physicians, Nevada
Sponsor class: OTHER
First posted: 2015-02-23
Enrollment: 288
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients presenting to the Emergency Departmetn suspicious of DVT

Brief summary: Emergency Medicine (EM) Residents routinely conduct bedside ultrasound exams in the Emergency Department (ED) employing the two point compression method. This study endeavors to investigate the accuracy and utility of bedside ultrasound for Deep Vein Thrombosis (DVT) in the ED by EM Residents by comparing the results of that exam against the gold standard of a DVT ultrasound performed in the Radiology Department and interpreted by a Radiologist.

Detailed description: For subjects with suspicion of DVT to the Emergency Department, an EM Resident will perform a bedside non-diagnostic two point compression DVT Ultrasound. Subjects will then receive a diagnostic DVT Ultrasound in the Radiology Department with official radiologist interpretation. The bedside ultrasound will not interfere with or delay the diagnostic ultrasound. Patient demographic and clinical data will be collected for validation purposes. Validation of the The EM Resident interpretation will be accomplished by comparison to the official Radiologist interpretation.

Eligibility criteria: Inclusion Criteria:

* Age 18 or older
* Suspect of having DVT

Exclusion Criteria:

* Known DVT
* DVT with in previous 6 months
* DVT Ultrasound within the last 6 months

Primary outcomes:
measure: Outcome measures is the proportion of agreement between Resident performed two point DVT ultrasaound and the Radiologist interpertation of a formal DVT ultrasound.
timeFrame: 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Las Vegas
country: United States
facility: University Medical Center of Southern Nevada
state: Nevada
Study officials:
affiliation: Emergency Medicine Physicians
name: Jamie Baydoun, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05066763: Parkinson's Foundation Surveys
Official title: Parkinson's Foundation Surveys
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Parkinson Disease
Lead sponsor: Parkinson's Foundation
Sponsor class: OTHER
First posted: 2021-10-04
Enrollment: 1000000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: People with Parkinson's disease, care partners of people with Parkinson's disease, health professional that treats people with Parkinson's disease

Brief summary: Parkinson's Foundation Surveys is an initiative seeking to periodically survey people with Parkinson's disease (PD), their care partners and medical professionals to better understand specific aspects of living with PD.


Eligibility criteria: Inclusion Criteria:

* Willingness to be contacted by the Parkinson's Foundation for surveys and any future research opportunities
* Anyone who self-reports that they have a diagnosis of Parkinson's disease
* Care partner of a person with Parkinson's disease
* Any health professional that regularly works with people with Parkinson's disease
* 18 years of age or older

Exclusion Criteria:

* People who report that they do not have a diagnosis of Parkinson's disease, are not a care partner to someone with PD or do not work with people with PD in the health setting
* An individual younger than 18 years of age

Primary outcomes:
measure: Total number of survey respondents
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Miami
country: United States
facility: Parkinson's Foundation
state: Florida
Study officials:
References:
Clinical trial NCT05373563: Quality of Postpartum Cesarean Recovery Score Validity Reliability
Official title: Quality of Postpartum Cesarean Recovery Score Validity Reliability
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Failed VBAC (Vaginal Birth After Cesarean)
Lead sponsor: Ondokuz Mayıs University
Sponsor class: OTHER
First posted: 2022-05-13
Enrollment: 1
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Study study of 18 patients using large cesarean section.

Brief summary: In order to provide the best care of patients after cesarean section, to help solve all their biopsychosocial problems in the recovery process, and to shorten the hospitalization period, it should be measured with appropriate measurement tools for various evaluations. The Scale of Post-cesarean Healing Quality You will provide in adapting the ObsQoR-11 questionnaire to Turkish.

Detailed description: In order to provide the best care of patients after cesarean section, to help solve all their biopsychosocial problems in the recovery process, and to shorten the hospitalization period, it should be measured with appropriate measurement tools for various evaluations. We will provide the Scale of Post-Cesarean Healing Quality in adapting the ObsQoR-11 questionnaire to Turkish.It is important to define well the recovery after cesarean section.

Eligibility criteria: Inclusion Criteria:

* Must be Over 18 age,
* Must be literate women,
* Must be no neurological disease

Exclusion Criteria:

* Must be unwilling to participate in the study
* Must be under 18 years old women

Primary outcomes:
measure: Quality of Postpartum Cesarean Recovery Score validity reliability
timeFrame: July 2022-October 2022
measure: obstetric qualityof- recovery score (ObsQoR-11)
timeFrame: About six mount
Secondary outcomes:
Other outcomes:
Locations:
city: Samsun
country: Turkey
facility: Samsun Health Directorate
state: Black Sea
Study officials:
affiliation: Samsun Provincial Health Directorate
name: Dilek Kıymaz,, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Samsun Provincial Health Directorate
name: Esra Saraçoğlu, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT03160963: Clinical Power Testing Across Human Lifetime
Official title: Optimal Manner of Measuring Power Across the Lifespan
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aged
Keywords: elderly
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2017-05-19
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Men and women 18-100

Brief summary: We will determine when to transition from the common vertical jump to chair stand depending on age and physical activity levels.

Detailed description: Assessing individuals' power, while it is useful in measuring fitness and performance levels, often requires expensive materials. Vertical jump height has been used to assess peak power output using specific regression equations. The issue with this test, although it is often used with older persons, is that it is not practical or useful in assessing the power output in elderly adults due to possible injury risk and lack of familiarity with providing a maximal jump performance. Power is important for elderly adults; because, higher power output in elderly adults has been shown to highly correlate with overall functionality, the ability to do activities of daily living (ADL), and a reduction in fall probability. A recent study examined the capacity of a regression equation to quantify power in elderly adults using a sit-to-stand test and determined; however, the sit-to-stand lacks the difficulty and exhibits a ceiling effect in younger individuals. Therefore, this study will attempt to determine when to transition from the vertical jump to the sit-to-stand, so that the differences in chronological versus physiological age may be determined during aging, and conversely, during improvements through physical or other interventions.

Eligibility criteria: Inclusion Criteria:

* between 18 and 89 years old willing to commit to two days of testing

Exclusion Criteria:

* severe musculoskeletal impairment,
* neurological impairment that would affect balance,
* severe cognitive impairment (Mini-mental 19 or below),
* unstable chronic disease state,
* severe vestibular problems
* severe orthostatic hypotension,
* Simultaneous use of cardiovascular, psychotropic and antidepressant drugs.
* Adults unable to consent
* Prisoners
* Pregnant females

Primary outcomes:
measure: 30 second stand-up test
timeFrame: 5 minutes
measure: Countermovement jump test
timeFrame: 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Coral Gables
country: United States
facility: Max Orovitz Laboratories
state: Florida
Study officials:
affiliation: University of Miami
name: Joseph F Signorile, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01435863: A Phase 1 Study of SP-02L in Relapsed or Refractory Patients With Peripheral T-cell Lymphoma (PTCL)
Official title: A Phase 1 Study of SP-02L (Darinaparsin for Injection) in Relapsed or Refractory Patients With Peripheral T-cell Lymphoma (PTCL)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Peripheral T-cell Lymphoma
Lead sponsor: Solasia Pharma K.K.
Sponsor class: INDUSTRY
First posted: 2011-09-19
Enrollment: 17
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the safety and tolerability of SP-02L monotherapy in Japanese patients with relapsed or refractory Peripheral T-cell Lymphoma (PTCL).


Eligibility criteria: Inclusion Criteria:

* Japanese patients aged ≥ 20 years of age at the day of obtaining the informed consent
* Patients with histologically confirmed diagnosis of the following:
* Peripheral T-cell Lymphoma, not otherwise specified (PTCL-NOS)
* Anaplastic Large Cell Lymphoma (ALCL ALK-positive/negative)
* Angioimmunoblastic T-cell Lymphoma (AITL)
* Have relapsed or refractory to at least one prior systemic chemotherapy for the above disease (currently requiring therapy)
* Have at least 1 evaluable lesion
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
* Life expectancy of at least 3 months

Primary outcomes:
measure: Incidence of dose-limiting toxicity and adverse events
timeFrame: 12 or 16 weeks
Secondary outcomes:
measure: Tumor response (overall response)
timeFrame: 2 and 4 cycles
measure: Plasma concentration-time profile
timeFrame: 0, 0.5, 1, 2, 4, 8 hours post-dose on Day 1 and 5, and 0 hour on Day 2, 3, 4, 6, 8 and 15
Other outcomes:
Locations:
city: Nagoya
country: Japan
state: Aichi
city: Sendai
country: Japan
state: Miyagi
city: Fukuoka
country: Japan
city: Tokyo
country: Japan
Study officials:
References:
citation: Ogura M, Kim WS, Uchida T, Uike N, Suehiro Y, Ishizawa K, Nagai H, Nagahama F, Sonehara Y, Tobinai K. Phase I studies of darinaparsin in patients with relapsed or refractory peripheral T-cell lymphoma: a pooled analysis of two phase I studies conducted in Japan and Korea. Jpn J Clin Oncol. 2021 Feb 8;51(2):218-227. doi: 10.1093/jjco/hyaa177.
Clinical trial NCT00186563: A Human In-vivo Model for the Detection of Inflammatory and Nociceptive Biomarkers
Official title: Proof-of-concept Study for Bio-marker Assay Validation in Humans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Skin Diseases
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2005-09-16
Enrollment: 13
Sex: ALL
Minimum age (years): 21
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: This study aims to establish a novel approach assisting the rational development of analgesic and anti-inflammatory drugs. In a first step we will test in healthy human volunteers whether proteins mediating inflammation and pain can be detected in an experimentally induced inflammatory skin lesion. Fluids that will be used to detect such proteins will be collected from the inflamed skin site via small porous catheters. We wish to establish the expression pattern of different proteins and correlate it with various tests assessing pain.


Eligibility criteria: Inclusion Criteria:1. Age between 21-60. 2. Skin type II or III according to the classification of Fitzpatrick (II: fair skin, always burns, sometimes tans, III: medium skin, sometimes burns, always tans).\&#xA; Exclusion Criteria:1. History of a significant systemic disease, a dermatological disease, bleeding disorder, or chronic pain.

2. Consumption of analgesic drugs. 3. Hypersensitivity to sunlight.

Primary outcomes:
measure: Cytokine-release profile in response to inflammation, noxious heat, and asministration of a COX-inhibitor
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University School of Medicine
state: California
Study officials:
affiliation: Stanford University
name: Martin S Angst
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05955963: Bowel Sounds Analysis in Paediatric Inflammatory Bowel Disease: Relationship With wPCDAI
Official title: Bowel Sounds Analysis in Paediatric Inflammatory Bowel Disease: Relationship With wPCDAI
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Bowel Sounds
Intestinal Inflammation
Crohn Disease
Keywords: bowel sounds
Intestinal Inflammation
Crohn Disease
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2023-07-21
Enrollment: 49
Sex: ALL
Minimum age (years): 4
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The precise and noninvasive evaluation of disease activity among patients with Crohn's disease is not easy, especially for children. It deals with clinical, biological, histological and radiological parameters.

Bowel sounds (BS) when evaluated by a stethoscope are modified by several factors including surgery, infection, drugs or intestinal inflammation. These factors can interact on intestinal motricity. There is a direct relationship between gastrointestinal motility and characteristics of BW. The study of BS using a stethoscope is a simple method, although operator dependent and subjective,with a wide inter and intraindividual variability. Some studies among adults showed interest in the spectral analysis of BS to assess gastrointestinal motility. This more precise and reproducible method is not operator dependent.

To date, no such study has evaluated the correlation between disease activity and the spectral pattern of BS.

of this project is to assess the correlation between disease activity and the spectral pattern of BS in pediatric Crohn's disease.


Eligibility criteria: Inclusion Criteria:

* Crohn's Disease
* Age between 4 and 17 years
* Follow-up at CHU Amiens-Picardie

Exclusion Criteria:

* Other diseases than Crohn's or treatments affecting the gastrointestinal tract, recent (\< 3 months) surgery or refusal to participate (parents or children)

Primary outcomes:
measure: evaluation of frequency of bowel sounds
timeFrame: one day
measure: evaluation of wPCDAI
timeFrame: one day
measure: correlation between wPCDAI and frequency of bowel sounds
timeFrame: one day
Secondary outcomes:
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens
Study officials:
References:
Clinical trial NCT00973063: Effectiveness of Routine Sterile Gloving in Blood Culture
Official title: Influence of Routine Sterile Gloving on Contamination Rates in Blood Culture
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bacteremia
Keywords: bacteremia
blood culture
contamination
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2009-09-09
Enrollment: 1854
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to determine whether routine sterile gloving can lower contamination rates in blood culture.

Detailed description: Because contamination during sampling for blood culture may interfere in interpreting the results of blood culture, lowering the contamination rates in blood culture is very important. According to current guideline, routine sterile gloving is not recommended. We hypothesized that routine sterile gloving can lower contamination rates in blood culture.

Eligibility criteria: Inclusion Criteria:

* The patients in whom Blood culture is medically needed

Exclusion Criteria:

* Blood sample is obtained through central venous catheter or arterial line
* No consent to this study

Primary outcomes:
measure: contamination rate in blood culture
timeFrame: at the time of identification of organisms
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: WAN BEOM PARK, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kim NH, Kim M, Lee S, Yun NR, Kim KH, Park SW, Kim HB, Kim NJ, Kim EC, Park WB, Oh MD. Effect of routine sterile gloving on contamination rates in blood culture: a cluster randomized trial. Ann Intern Med. 2011 Feb 1;154(3):145-51. doi: 10.7326/0003-4819-154-3-201102010-00003.
Clinical trial NCT04453163: Interest of the Patient Management by Improved Recovery After Surgery in Percutaneous Vertebroplasty
Official title: Interest of Improved Recovery After Surgery (IRAS) Management [RAAC in French] in Percutaneous Vertebroplasty
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vertebral Compression
Lead sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche
Sponsor class: OTHER
First posted: 2020-07-01
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This research aims to demonstrate the benefits of the RAAC program for patients undergoing cementoplasty, in particular on their level of anxiety and pain control throughout the perioperative phase.

Detailed description: The aim of the study is to compare the preoperative anxiety of patients hospitalized for a percutaneous vertebroplasty, depending on whether or not they are managed in an RAAC program.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 80 years or ≥ 18 years with oncological history;
* Patient with vertebral compression fracture with indication for percutaneous vertebroplasty;
* Patient seen in preoperative anesthesia / radiology consultation more than 4 days before the date of the vertebroplasty;
* Having expressed their consent to participate in the study.

Exclusion Criteria:

* Patient with a contraindication to percutaneous vertebroplasty, such as coagulation disorders, or an allergy or hypersensitivity to any of the products administered during the procedure;
* Patient not affiliated to a social security scheme;
* Patient participating in another clinical trial during the follow-up period;
* Inability to understand information related to the study (linguistic, psychiatric, cognitive reason, etc.).

Primary outcomes:
measure: Superiority of Improved Recovery After Surgery versus standard management over preoperative anxiety
timeFrame: 10 days
Secondary outcomes:
measure: Pain evaluation
timeFrame: 10 days
measure: Patient satisfaction
timeFrame: 10 days
measure: Functional impotence
timeFrame: 10 days
measure: Consumption of analgesics
timeFrame: 10 days
Other outcomes:
Locations:
city: Bayonne
country: France
facility: Clinique Belharra
Study officials:
References:
Clinical trial NCT01070563: Transcranial Doppler Ultrasonography and Brain Death
Official title: Evaluation of Transcranial Doppler Ultrasonography to Guide the Time of Cerebral Angiography for the Brain Death Diagnosis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Brain Dead
Keywords: Brain death
CT angiography
Ultrasonography, doppler, transcranial
Lead sponsor: Institut d'Anesthesiologie des Alpes Maritimes
Sponsor class: OTHER
First posted: 2010-02-18
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: ICU patients showing brain injury due to stroke or trauma and developping subsequently brain death

Brief summary: In France the diagnosis of brain death relies on electroencephalography (EEG) or cerebral angiography. Concerning the latter a time of 6 hours is mandatory between the clinical diagnosis and the realization of the cerebral computed tomography (CT) angiography. Transcranial doppler (TCD) is not recommended in the french guidelines for the diagnosis of brain death. In other countries, some flow patterns allow to confirm the diagnosis of brain death. The hypothesis of our study is that TCD could shorten the time between the clinical diagnosis of brain death and the realization of the CT angiography.


Eligibility criteria: Inclusion Criteria:

* brain death patients

Exclusion Criteria:

* craniectomy
* post anoxia encephalopathy
* no TCD performed before the clinical diagnosis of brain death
* transtemporal approach impossible

Primary outcomes:
measure: Time between clinical diagnosis of brain death and realization of CT angiography
timeFrame: the outcome is assessed when the CT angiography is performed
Secondary outcomes:
measure: Number of CT angiography required for the diagnosis of brain death
timeFrame: the outcome is measured until the diagnosis of brain death is confirmed
Other outcomes:
Locations:
city: Nice
country: France
facility: Centre Hospitalier Universitaire de Nice
Study officials:
affiliation: Nice University Hospital
name: Jean-Christophe Orban, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Orban JC, El-Mahjoub A, Rami L, Jambou P, Ichai C. Transcranial Doppler shortens the time between clinical brain death and angiographic confirmation: a randomized trial. Transplantation. 2012 Sep 27;94(6):585-8. doi: 10.1097/TP.0b013e3182612947.