Clinical trial NCT02180425: The Lipid Profile of the Skin Surface in Acne
Official title: The Lipid Profile of the Skin Surface in Acne
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acne
Keywords: acne
lipid
tretinoin
isotretinoin
Lead sponsor: University of California, Davis
Sponsor class: OTHER
First posted: 2014-07-02
Enrollment: 30
Sex: ALL
Minimum age (years): 12
Maximum age (years): 30
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects will be from the UC Davis Dermatology Clinic, surrounding dermatology clinics, from the UC Davis undergraduate campus, and from the California State University Sacramento campus.

Brief summary: The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.

Detailed description: Skin lipid profile will be conducted via sebutapes- adhesive tapes that painlessly absorbs sebum from the face. These tapes will be placed on the face for 1 hour. A photograph of the face will be taken during each study visit. A sebumeter will also be used to measure skin sebum secretion rate.

Eligibility criteria: Inclusion Criteria:

* age 12 to 30 years
* have been prescribed tretinoin OR isotretinoin

Exclusion Criteria:

* those who have taken isotretinoin (systemic)
* those who used tretinoin or other topical retinoid within two weeks of starting the study
* those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome
* those who are pregnant, prisoners, or cognitively impaired
* those who do not fit the inclusion criteria

Primary outcomes:
measure: Skin lipid profile of acne and healthy patients
timeFrame: baseline visit
Secondary outcomes:
measure: Skin lipid profile of acne patients after treatment
timeFrame: at 1 month and 4-5 months of treatment
Other outcomes:
Locations:
city: Davis
country: United States
facility: Dermatology Research Area
state: California
city: Sacramento
country: United States
facility: UC Davis Department of Dermatology
state: California
Study officials:
affiliation: UC Davis
name: Raja K Sivamani, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Thody AJ, Shuster S. Control and function of sebaceous glands. Physiol Rev. 1989 Apr;69(2):383-416. doi: 10.1152/physrev.1989.69.2.383.
citation: Blume U, Verschoore M, Poncet M, Czernielewski J, Orfanos CE, Schaefer H. The vellus hair follicle in acne: hair growth and sebum excretion. Br J Dermatol. 1993 Jul;129(1):23-7. doi: 10.1111/j.1365-2133.1993.tb03306.x.
citation: Zouboulis CC, Baron JM, Bohm M, Kippenberger S, Kurzen H, Reichrath J, Thielitz A. Frontiers in sebaceous gland biology and pathology. Exp Dermatol. 2008 Jun;17(6):542-51. doi: 10.1111/j.1600-0625.2008.00725.x.
citation: Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997 Jun;36(6):416-8. doi: 10.1046/j.1365-4362.1997.00099.x. No abstract available.
citation: Morello AM, Downing DT, Strauss JS. Octadecadienoic acids in the skin surface lipids of acne patients and normal subjects. J Invest Dermatol. 1976 May;66(5):319-23. doi: 10.1111/1523-1747.ep12482300.