Clinical trial NCT02226640: Uncovering the 'ORIGINS' of Diabetes
Official title: Uncovering the 'ORIGINS' of Diabetes
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Type 2 Diabetes
Lead sponsor: AdventHealth Translational Research Institute
Sponsor class: OTHER
Collaborators: name: AdventHealth
name: Sanford-Burnham Medical Research Institute
name: UCSF Benioff Children's Hospital Oakland
name: Duke Univeristy Sarah W. Stedman Nutrition & Metabolism Center
First posted: 2014-08-27
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Community sample

Brief summary: This is a study to identify different subtypes of type 2 diabetes. The investigators will look for information at the molecular level, which may lead to personalized diagnosis and therapies.

Detailed description: Type 2 diabetes mellitus (T2DM) is approaching epidemic prevalence in the US adult population (over 1 in 10 of all US adults over 20). Diabetes is diagnosed based on fasting hyperglycemia, oral glucose intolerance or markers of hyperglycemia such as HbA1c. However, we now recognize that diabetes is a heterogeneous disorder. With the existing overly simplistic diagnostic criteria, treatment failure rates are high for virtually every agent currently in the drug arsenal - including insulin. In the late 1990's oncologists pioneered the use of high-throughput molecular technologies, such as transcriptome profiling and more recently metabolomics to identify discrete sub-classes of cancers that cannot be distinguished histologically or by a small number of biochemical markers. That effort rapidly accelerated the pace of scientific discovery and quickly led to the development of personalized cancer therapeutics. We believe that those cancer efforts provide a roadmap for biomarker discovery and personalized therapy in diabetes. molecular phenotyping (profiling the metabolome, transcriptome, and epigenome) with advanced bioinformatics analysis will identify discrete subtypes of diabetes - ushering in a new era of personalized diagnosis and therapy in diabetes.

Eligibility criteria: Inclusion Criteria:

* Age \> 18
* HbA1C \< 8.0% \*
* You have not gained or lost more than 3 kg or 6.6 pounds in the last 8 weeks
* You have not lost more than 10% of your heaviest body weight in your lifetime
* BMI \< 25 kg/m2 or \> 30 kg/m2
* Women: more than 1 year post-partum
* Have diabetes and are able to maintain accurate and reliable home glucose monitoring logs

Exclusion Criteria:

* Treatment with more than 2 of the following: metformin (Fortamet, Glucophage, Glumetza, Riomet), sulfonylureas (Glucotrol, Diabeta, Glynase, Micronase), Glucagon-like peptide-1 analogs (Byetta) and/or Dipeptidyl peptidase IV inhibitors (Januvia, Onglyza)
* Treatment with long acting Glucagon-like peptide-1 agonists within the last 3 months (i.e. exenatide once weekly)
* Treatment with thiazolidinediones (TZDs) (i.e. Avandia, Actos, Rezulin) within the last 3 months
* Known, untreated thyroid disease or abnormal thyroid function blood test.\*
* Known diagnosis of liver disease (except NASH) or elevated liver function blood test
* Known diagnosis of kidney disease or elevated kidney function blood test
* Uncontrolled high blood pressure (BP \> 140 systolic or \> 90 diastolic)
* Start of or changes in oral contraceptives or hormone replacement therapy within the last 3 months
* Use of drugs or alcohol (\> 3 drinks per day) within the last 5 years.
* Uncontrolled psychiatric disease that would interfere with study participation.
* History of cancer within the last 5 years (skin cancers, with the exception of melanoma, may be acceptable)
* History of organ transplant
* History of heart attack within the last 6 months
* Current treatment with blood thinners or antiplatelet medications that cannot be safely stopped for testing procedures
* Current anemia
* History of HIV, active Hepatitis B or C, or Tuberculosis
* Presence of clinically significant abnormalities on electrocardiogram.
* Current smokers (smoking any nicotine or non-nicotine product within the past 3 months)
* Use of any medications known to influence glucose, fat and/or energy metabolism within the last 3 months (e.g., growth hormone therapy, glucocorticoids \[steroids\], etc.)

Primary outcomes:
measure: Perform 'deep' clinical and molecular phenotyping of 360 adults- Diabetic and Non-Diabetic
timeFrame: up to Day 9
Secondary outcomes:
Other outcomes:
Locations:
city: Orlando
country: United States
facility: Translational Research Institute for Metabolism and Diabetes
state: Florida
Study officials:
affiliation: Translational Research Institute for Metabolism and Diabetes
name: Steven R Smith, MD
role: PRINCIPAL_INVESTIGATOR
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