Clinical trial NCT03644329: Effect of Resistance Training Variable Manipulation in Postmenopausal Breast Cancer Survivors.
Official title: Effect of Resistance Training Variable Manipulation (Intensity and Volume) on Body Composition, Fatigability and Functional Capacity in Postmenopausal Breast Cancer Survivors.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Breast Cancer Survivors
Postmenopause
Keywords: Breast Cancer Survivors
resistance Training
fatigability
Body Composition
Functional capacity
Lead sponsor: Universidade Federal do Triangulo Mineiro
Sponsor class: OTHER
First posted: 2018-08-23
Enrollment: 80
Sex: FEMALE
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study intends to evaluate the impact of resistance training variable manipulation (intensity and volume) on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.

Detailed description: The treatment for breast cancer (chemotherapy, radiotherapy and hormone therapy) provokes collateral effects,such as muscle mass and strength losses, increase of fat mass, fatigue and disability and reduced quality of life in postmenopausal breast cancer survivors. The resistance training is assumed as a non-pharmacologic interventions in postmenopausal breast cancer survivors. However, it is unclear whether the manipulation of training variables (intensity and volume) maximize the effects of resistance training on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.

Eligibility criteria: Inclusion Criteria:

* Postmenopausal breast cancer survivors;
* No supervised or unsupervised exercise at least for six months prior to the study.

Exclusion Criteria:

* Alcoholics;
* No controlled blood pressure and glucose;
* Presence of myopathies, arthropathies, and neuropathies;
* Presence of muscle, thromboembolic and gastrointestinal disorders, infection diseases.

Primary outcomes:
measure: Evaluation the Fatigability
timeFrame: pre and post intervention (i.e. 12 weeks)
Secondary outcomes:
measure: Four- meter walk test
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: Fat mass
timeFrame: pre intervention and post intervention (i.e. 12 weeks)
measure: Muscle strength
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: Six Minutes-walk test (6MWT)
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: Timed Up and Go test
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: Five-times-sit-to-stand test
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: Muscle mass
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: 10-meter walk test
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: 400-meter walk test
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: 900-meter walk test
timeFrame: pre and post intervention (i.e. 12 weeks)
Other outcomes:
measure: Rate of force development (RFD)
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: Electromyography
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: Physical activity level
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: Evaluation the quality of life
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: Self-report fatigue
timeFrame: pre and post intervention (i.e. 12 weeks)
measure: Cytokines
timeFrame: pre and post intervention (i.e. 12 weeks)
Locations:
city: Uberaba
country: Brazil
facility: Post-degree program in physical education
state: MG - Minas Gerais
Study officials:
affiliation: Federal University of Triângulo Mineiro
name: Fábio L Orsatti, PhD
role: PRINCIPAL_INVESTIGATOR
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