Clinical trial NCT03394235: Optimizing Parameters for Long-pulsed Nd:YAG Laser for Reducing Hair Shaft Diameter
Official title: Optimizing Parameters for Long-pulsed Nd:YAG Laser for Reducing Hair Shaft Diameter at the Donor Area for Hair Transplantation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Androgenetic Alopecia
Hair Loss/Baldness
Keywords: hair transplant
hairline
laser hair removal
Lead sponsor: Institute of Dermatology, Thailand
Sponsor class: OTHER_GOV
First posted: 2018-01-09
Enrollment: 14
Sex: ALL
Minimum age (years): 25
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: This is a pilot study. We plan to enroll 15 participants who requires to do hair transplantation or normal participants who are eligible for the study.
Primary purpose: TREATMENT

Brief summary: This study evaluates the optimizing parameters of long pulse Nd:YAG Laser for reducing the size of hair shaft diameter of the donor for hair transplantation. All participants will receive long-pulsed Nd-YAG laser treatments with three different parameters at the occipital area.

Detailed description: Since the beginning of hair transplantation era, hair transplant technique has been greatly improved to achieve the best natural looking of hairline and hair density. Most Asians tend to have large size of hair shaft at the donor area, which often cause unnatural look of the hairline at the frontal area after hair transplantation due to the contrast between the transplanted hair and the original hair.

The idea of reducing the size of the hair shaft in the certain part of donor area before being transplanted to the frontal hairline becomes appealing. This transection is being practiced extensively in the field of cosmetic medicine by using long-pulsed Neodymium-Doped:Yttrium Aluminum Gamet (Nd:YAG), a laser treatment for permanent hair removal and vascular lesions.

Eligibility criteria: Inclusion Criteria:

* Men and women, aged 25-60 years with AGA or healthy
* Completed informed consent form

Exclusion Criteria:

* Pregnancy or breastfeeding
* Acute infection on the scalp or any systemic infection
* Immunocompromised host
* Chronic wasting diseases
* Use of any medications which may affect hair loss such as anticoagulants, anti-hypertensive, hormones, anticonvulsants, retinoid, mood stabilizers and antidepressants
* Unstable medical problems which may affect hair loss such as thyroid diseases, autoimmune diseases, myocardial infarction, coronary bypass surgery, unstable angina, cardiac arrhythmias, congestive heart failure, cerebrovascular accident and psychiatric problems
* Hair thinning at the occipital area

Primary outcomes:
measure: Evaluate the changes in hair density at the treated sites.
timeFrame: 24 weeks
Secondary outcomes:
measure: Evaluate the changes in hair diameter at the treated sites.
timeFrame: 24 weeks
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Institute of Dermatology
Study officials:
affiliation: Institute of Dermatology
name: Chinmanat Tangjaturonrusamee, MD
role: STUDY_DIRECTOR
References: