Clinical trial NCT06969339: Unilateral Posterior Wedge Closing Vertebral Column Resection for Treatment of Congenital Kyphoscoliosis
Official title: Unilateral Posterior Wedge Closing Vertebral Column Resection for Treatment of Adolescent Neglected Congenital Kyphoscoliosis
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Unilateral Posterior Wedge Closing
Keywords: unilateral posterior wedge closing
neglected congenital kyphoscoliosis
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-05-13
Enrollment: 15
Sex: ALL
Minimum age (years): 10
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population consisted of adolescents (mean age 15.7 years) with neglected congenital kyphoscoliosis, who had not undergone any prior spinal surgery and had complete preoperative and follow-up imaging data. The sample represents a total coverage of all cases meeting criteria during the study period, reflecting the rarity of congenital kyphoscoliosis requiring surgical intervention in adolescence, The patients who have moderate to severe spinal deformity, with a mean preoperative Cobb angle of 53.2° (kyphoscoliosis involves abnormal curvature in both sagittal and coronal planes, hese cases typically present during adolescence, coinciding with the second growth spurt, which is a known period for progression of congenital spinal deformities

Brief summary: A retrospective analysis of 12 adolescents undergoing unilateral posterior wedge closing VCR for neglected congenital kyphoscoliosis, assessing surgical outcomes over a mean 2.9-year follow-up.

Detailed description: Design: Single-center case series (Assiut University Hospital, 2015-2020).

Intervention: Modified posterior VCR with unilateral convex wedge resection, spinal shortening, and instrumentation.

Key Steps:

Preoperative CT/MRI for anatomical planning.

Posterior-only approach with pedicle screw instrumentation.

Wedge resection focused on convex side, preserving concave continuity.

Bone grafting (cancellous or mesh cage) post-correction.

Follow-up: Radiographic and clinical assessments up to 2 years post-surgery.

Eligibility criteria: Inclusion Criteria:

Age \>10 years.

Congenital kyphoscoliosis diagnosis.

No prior spinal surgery.

Preoperative CT/MRI and 24-month follow-up data.

Exclusion Criteria:

Idiopathic or neuromuscular scoliosis

Previous spinal surgery

Incomplete radiographic or follow-up data

Primary outcomes:
measure: Cobb angle correction
timeFrame: Baseline, and 2-year follow-up.
Secondary outcomes:
measure: Blood loss
timeFrame: Intraoperative
Other outcomes:
Locations:
Study officials:
References:
citation: Suk SI, Kim JH, Kim WJ, Lee SM, Chung ER, Nah KH. Posterior vertebral column resection for severe spinal deformities. Spine (Phila Pa 1976). 2002 Nov 1;27(21):2374-82. doi: 10.1097/00007632-200211010-00012.
citation: Yang JH, Kim HJ, Chang DG, Suh SW, Nam Y, Hong JY. The Efficacy of Single-Stage Correction by Posterior Approach for Neglected Congenital Scoliosis: Comparative Analysis According to the Age of Surgical Intervention. J Clin Med. 2022 Apr 19;11(9):2278. doi: 10.3390/jcm11092278.