Clinical trial NCT02709863: Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests
Official title: Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests in Patients Undergoing Endoscopic Endonasal Transsphenoidal Surgery of Pituitary Gland
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pituitary Adenoma
Lead sponsor: Istanbul University
Sponsor class: OTHER
First posted: 2016-03-16
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland. Participants will be divided into three equal groups. The first group will receive sevoflurane, second grup will receive desflurane and third grup will receive total intravenous anaesthesia. Investigators are also going to evaluate blood gas analysis.

Detailed description: Investigators are going to evaluate forced expiratory volume in 1st Second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, partial pressure of arterial oxygen (PaO2), partial pressure of arterial carbon dioxide (PaCO2), potential of hydrogen (pH), arterial oxygen saturation (SaO2), base excess (BE), bicarbonate (HCO3) and partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio to compare the effects of drugs.

Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists (ASA) score I-II patients

Exclusion Criteria:

* Significant cardiopulmonary disease,
* Diagnosed obstructive or restrictive pulmonary disease,
* Patients with chest wall deformities, liver or kidney failure,
* Postoperative lack of cooperation

Primary outcomes:
measure: Change from baseline FEV1%predicted (no unit)
timeFrame: Preoperative baseline, postoperative 1st hour and postoperative 24th hour
Secondary outcomes:
measure: Change from baseline FVC%predicted (no unit)
timeFrame: Preoperative baseline, postoperative 1st hour and postoperative 24th hour
measure: Change from baseline FEV1/FVC ratio (no units)
timeFrame: Preoperative baseline, postoperative 1st hour and postoperative 24th hour
measure: Change from baseline PaO2 (mmHg)
timeFrame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour
measure: Change from baseline PaCO2 (mmHg)
timeFrame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour
measure: Change from baseline pH
timeFrame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour
measure: Change from baseline SaO2 (%)
timeFrame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour
measure: Change from baseline BE (mmol/L)
timeFrame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour
measure: Change from baseline HCO3 (mmol/L)
timeFrame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour
measure: Change from baseline PaO2/FiO2 ratio (no units)
timeFrame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul University Cerrahpasa Medical Faculty Neurosurgery Department
Study officials:
affiliation: Istanbul University
name: Özlem Korkmaz Dilmen, Assoc. Prof.
role: STUDY_DIRECTOR
References: