Clinical trial NCT02145286: Phase 1/2 Study to Determine Optimal Dose for Treating Bone Metastases Using Novel STAT-RT Workflow
Official title: A Phase I/II Single Arm Prospective Single Fraction Real-time Stereotactic Body Radiation Therapy Dose Escalation Trial of Rapid Helical TomoTherapy-based Radiation Therapy for Patients With Painful Osseous Metastatic Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Metastatic Bone Lesion
Lead sponsor: University of Virginia
Sponsor class: OTHER
First posted: 2014-05-22
Enrollment: 47
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this research study is to evaluate the safety and effectiveness of an experimental procedure called Focused Radiation that may result in a faster way to plan and deliver radiation for the treatment of pain caused by metastatic bone tumors (cancerous tumors that originally came from another organ and have spread to bones). In this trial a single fraction of radiation will be given from 8-15 Gray.

Detailed description: The purpose of this research study is to evaluate the safety and effectiveness of an experimental procedure called Focused Radiation that may result in a faster way to plan and deliver radiation for the treatment of pain caused by metastatic bone tumors (cancerous tumors that originally came from another organ and have spread to bones).

Focused radiation (the radiation is focused on the tumor in the bone with reduced radiation dose to the normal tissues) is used as standard of care treatment for patients with painful metastatic tumors in their spines with just one treatment. In this study, the focused radiation will be used to treat tumors in other bones as well. The current standard of care radiation treatment planning and delivery can take 2 to 3 weeks from start to finish depending on how many treatments are given although the standard of care is to treat patients with 1-10 treatments. The University of Virginia has developed an experimental workflow/process: a radiation treatment planning and delivery workflow called "STAT RAD" (STAT means "right away", and RAD means radiation). This experimental workflow will shorten the time it takes to plan and treat painful bone metastases to 1-2 hours.

When only one treatment is given the standard radiation dose is 8 Gray. This has resulted in radiation retreatment rates to the treated bone of 20% in prior studies for persistent or recurrent bone pain. In this study patients will be treated with higher doses of targeted radiation to determine if higher doses, which have been reported to be safely delivered for bone metastases in the spine with very low re-treatment rates, can be safely delivered to non-spine bone metastases. After the treatment, patients will be followed for pain relief in the treated bone, need for pain medication, quality of life, toxicity, and the need to retreat the bone metastasis for persistent or recurrent pain.

Eligibility criteria: Inclusion Criteria:

* Patient has 1-3 major painful osseous metastases (target lesions)
* Radiographic evidence (CT, MR, or PET CT) consistent with osseous metastatic disease on CT, MR, or PET CT obtained within 4 weeks of treatment will be used for pre-study treatment delivery. The GTV of the target lesions will be determined from this radiographic study and must be ≤ 250 cubic centimeters.

NOTE: Patient is still eligible if a diagnostic image set is not available within 4 weeks of treatment if the patient will undergo a kVCT simulation in the Department of Radiation Oncology with contouring directly onto this image set.

* Patient is medically able to undergo palliative radiation therapy
* Patient has pain that is persistent and distinguishably associated with the target sites to be treated
* Planning Target Volume 1 (PTV1) must be \> 5mm from the spinal cord or brain
* Women of Childbearing age and men must consent to use adequate contraception for six months following study entry

Exclusion Criteria:

* Inability to lie on the treatment table for 1 hour
* Systemic therapeutic radionuclide delivery within 30 days prior to treatment
* Target lesions have been previously treated with external beam radiation
* Long bone target lesions with a Mirels fracture score \>7
* Unstable bone in the target lesion requiring surgical stabilization
* PTV1 is located within 5mm of spinal cord or brain
* A serious, uncontrolled medical disorder
* Pregnancy

Primary outcomes:
measure: Radiation Dose
timeFrame: Up to 12 months following treatment
Secondary outcomes:
measure: Single Treatment Pain Scores
timeFrame: Up to 4 weeks following treatment
measure: Paired Dose Pain Score Comparison
timeFrame: Up to 4 weeks following treatment
measure: Post Treatment Measures
timeFrame: Up to 12 months following treatment
Other outcomes:
Locations:
city: Charlottesville
country: United States
facility: University of Virginia Health System
state: Virginia
Study officials:
affiliation: University of Virginia
name: Paul W Read, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: