Clinical trial NCT06842368: Immediate Implant Placement Using Xenograft Mixed with Vitamin D Versus Hyaluronic Acid.
Official title: Immediate Implant Placement Using Xenograft As Space Filling Material Mixed with Vitamin D Versus Hyaluronic Acid in Posterior Mandible Region: a Randomized Controlled Clinical Trial.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Immediate Implant Placement
Keywords: Hyaluronic acid
Vitamin D
Xenograft
Immediate Implant
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-02-24
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized Controlled Clinical Trial. Parallel group study. Allocation Ratio 1:1.
Primary purpose: TREATMENT

Brief summary: Immediate implant placement using xenograft as space filling material mixed with vitamin D versus hyaluronic acid in posterior mandible region This study aims to evaluate implant stability and density after placement of immediate implant and Xenograft mixed with Hyaluronic acid or Vitamin D at posterior mandible region

Detailed description: Dental implants in fresh extraction sockets and healed sites have a erratic morphology, creating a wide space defect between the implant and buccal alveolar bone. This defect is critical for implant success, known as a jumping gap. Proper management of this space is essential for esthetic and functional success. Studies show adequate bone fill can be achieved in jumping gaps, but wider gaps increase implant body exposure risk.

The application of biological mediators embedded in the biomaterial can induce specific cell and tissue response, which can improve bone quality and quantity. Dental research has focused on improving bone substitutes by morphologic or bio- chemical modification.

Eligibility criteria: Inclusion Criteria:

Age: 18-60.

* Systemically healthy patients indicated for single or multiple immediate implants in posterior teeth region.
* Absence of any peri-apical pathosis.
* Patients with intact buccal plate of bone.
* Patients with adequate bone volume for the dental implant procedure.
* Patient with good oral hygrine

Exclusion Criteria:

* Heavy Smokers.
* Systemic disease that may affect the final outcome of the surgical procedure.
* No or poor patient's compliance.
* Patients with psychological problems.
* Pathology at the site of intervention.
* Patient with vit d deficiency

Primary outcomes:
measure: Implant secondary stability
timeFrame: after 6 months
Secondary outcomes:
measure: Density of bone around implant
timeFrame: after 6 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of dentistry ,Cairo university
Study officials:
References:
citation: Abd Elwahap, Mohammad et al. "Effect of Xenograft Alone versus Xenograft Mixed with Vitamin-D On Preservation of Alveolar Sockets of Chronically Infected Teeth." Al-Azhar Journal of Dental Science (2024): n. pag.
citation: ⦁ Elgazzar, A., Yousef, E., Amer, M. Effect of Hyaluronic Acid Mixed with Biphasic Calcium Phosphate on Bone Healing Around Immediately Placed Implants in the Posterior Area of the Mandible. Egyptian Dental Journal, 2023; 69(4): 2631-2641. doi: 10.21608/edj.2023.227200.2669