Clinical trial NCT05723939: Carnosine Supplementation and Cardiovascular Function
Official title: Effects of Carnosine Supplementation in Form of Capsules and Functional Food on Cardiovascular Function
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Carnosine
Keywords: carnosine
oxidative stress
vascular reactivity
endothelium
inflammation
microcirculation
macrocirculation
Lead sponsor: Josip Juraj Strossmayer University of Osijek
Sponsor class: OTHER
First posted: 2023-02-13
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It was originally discovered in skeletal muscle where it is present in larger amounts than in other tissues, but it is also found in high concentrations in the brain, heart, and gastrointestinal tissues of humans. Although its physiological role has not been completely understood yet, carnosine is a non-enzymatic free-radical scavenger and a natural antioxidant and has anti-inflammatory and neuroprotective properties.

The hypothesis of this research is that the consumption of carnosine supplements in the form of capsules, as well as chicken meat enriched with carnosine (functional food) has a beneficial effect on vascular reactivity measured in different vascular basins, and the lipid profile with a positive effect on the reduction of oxidative stress and inflammatory response in healthy sedentary people. subjects and active athletes measured in different vascular basins.

The main goal of this study is to investigate the influence of carnosine supplement consumption (in the form of capsules and functional food) on vascular and endothelial function in a population of healthy young subjects and active athletes.


Eligibility criteria: Inclusion Criteria:

* young healthy sedentary individuals - did not perform regular physical activities for at least 12 months before conducting the study
* young healthy active athletes - have a minimum of 5 training sessions per week (mainly endurance training) for at least 12 months prior to conducting the study

Exclusion Criteria:

* smoking
* hypertension
* coronary disease
* diabetes
* hyperlipidemia
* kidney damage
* cerebrovascular and peripheral artery diseases
* and any other disease that could have an impact on vascular and endothelial function

Primary outcomes:
measure: Microvascular endothelial function
timeFrame: 3 weeks
measure: Macrovascular endothelial function
timeFrame: 3 weeks
measure: Cerebrovascular reactivity
timeFrame: 3 weeks
Secondary outcomes:
measure: Lipid profile
timeFrame: 3 weeks
measure: Oxidative stress status
timeFrame: 3 weeks
measure: Systemic hemodynamics
timeFrame: 3 weeks
measure: Serum Pro- and Anti-Inflammatory Cytokines, Chemokines, Growth Factors and Soluble Cell Adhesion Molecules Protein Concentration
timeFrame: 3 weeks
measure: Body composition
timeFrame: 3 weeks
measure: Body fluid status
timeFrame: 3 weeks
measure: Oxidative stress status
timeFrame: 3 weeks
measure: Oxidative stress status
timeFrame: 3 weeks
measure: Systemic hemodynamics
timeFrame: 3 weeks
measure: Systemic hemodynamics
timeFrame: 3 weeks
Other outcomes:
Locations:
city: Osijek
country: Croatia
facility: Scientific Center of Excellence for Personalized Health Care, Josip Juraj Strossayer University of Osijek
Study officials:
References: