louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02511392: Repetitive Transcranial Magnetic Stimulation in the Treatment of Obsessive Compulsive Disorders
Official title: Repetitive Transcranial Magnetic Stimulation in the Treatment of Obsessive-Compulsive Disorders: Double Blind Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obsessive Compulsive Disorders
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2015-07-30
Enrollment: 45
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objectives.-Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive stimulation methods that became widely used as therapeutic tools in neuropsychiatric research. The aim of this study is to Evaluate the therapeutic impact of different frequencies of repetitive transcranial stimulation (1HZ, 10HZ) in OCD patients. Material and Methods; Forty five patients of OCD were participated in the study. All patients fulfilled the diagnostic criteria of DSM-IV-TR. The mean age of the patients was 27.1+4.5 years. Each patient was subjected to the following: Yale-Brown obsessive compulsive scale (Y-BOCS), Hamilton Anxiety Rating Scale (HAM-A), and Clinical Global Impression - Severity scale (CGI-S). The patients were randomly classified into three equal groups using closed envelop: 1st group received 1 Hz rTMS at 100% of the RMT, 2nd group received 10 Hz rTMS with intensity of 100% of the RMT and 3rd group was sham group received the sham stimulation with a total 2000 pulses every day for each group for 10 sessions. Follow up of the patients using the same previous scales after the end of sessions and 3 months later.


Eligibility criteria: Inclusion Criteria:

* All patients fulfilled the diagnostic criteria of DSM-IV-TR

Exclusion Criteria:

* Patients with comorbid psychiatric disorder .

Primary outcomes:
measure: changes of Y-BOCS
timeFrame: Base line and after 3 months
Secondary outcomes:
measure: Changes in HAM-A score
timeFrame: Base line and after 3 months
measure: Changes in CGI-S score
timeFrame: Base line and after 3 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04369092: Myotonometer Analyses of Muscles in Multiple Sclerosis Patients With Dysphagia
Official title: Myotonometric Assessment of Muscles in Multiple Sclerosis Patients With Dysphagia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Multiple Sclerosis
Dysphagia
Swallowing Disorder
Deglutition Disorders
Muscle Tonus
Lead sponsor: Hasan Kalyoncu University
Sponsor class: OTHER
First posted: 2020-04-30
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Multiple Sclerosis is a chronic inflammatory autoimmune neurological disease characterized by the destruction of myelin in the central nervous system, grey matter and axonal loss. The prevalence of neurogenic dysphagia in this group of patients is estimated to be more than 30%. The aim of this study was investigating of Masseter, Orbicularis Oris, Sternocleidomastoid muscles' viscoelastic properties in MS patients with and without swallowing problems.

Detailed description: The aim of this study was investigating of Masseter, Orbicularis Oris, Sternocleidomastoid muscles' viscoelastic properties in MS patients with and without swallowing problems. It carried out that myotonometric assessment of muscles in multiple sclerosis patients with dysphagia and comparison of these properties.

Eligibility criteria: Inclusion Criteria:

1. being diagnosed with Mc Donald's Multiple sclerosis (MS) in accordance with 2010 criteria,
2. being between the ages of 18-45.

Exclusion Criteria:

1. having psychological, orthopedic and other neurological disorders,
2. pregnancy,
3. having had an attack in the last 3 months,
4. application of botulinum toxin in the last 6 months.

Primary outcomes:
measure: Myotonometric Measurement
timeFrame: through study completion, average one hour
Secondary outcomes:
measure: Eating Assessment Tool
timeFrame: through study completion, average one hour
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Hasan Kalyoncu University
Study officials:
References:
Clinical trial NCT03139292: Comparative Evaluation of Ambu AuraGain Laryngeal Mask and Proseal Laryngeal Mask Airway
Official title: Comparative Evaluation of Ambu AuraGain Laryngeal Mask and Proseal Laryngeal Mask Airway in Spontaneously Breathing Patients Undergoing Elective Surgery Under General Anaesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Laryngeal Masks
Lead sponsor: Tata Main Hospital
Sponsor class: OTHER
First posted: 2017-05-03
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Prospective randomized single blinded parallel group controlled study
Primary purpose: TREATMENT

Brief summary: Comparison of two different supraglottic airway devices i.e., the ProSeal Laryngeal Mask Airway (PLMA) and Ambu AuraGain, a third generation laryngeal mask Airway.

Detailed description: The study aims to compare the two devices with respect to:

Time taken for insertion. Insertion attempts or failed attempt. Oropharyngeal leak pressure Air leak Time taken to pass an orogastric tube Attempts to pass an orogastric tube or failed attempt. Haemodynamic variation Incidence of adverse events like failed insertion, aspiration-regurgitation, hypoxia (SpO2\< 90%), bronchospasm, airway obstruction, gastric insufflation, coughing, gagging, retching, hiccup, coughing during removal, blood staining of the airway device and trauma to tongue, lip, teeth, or gums.

Eligibility criteria: Inclusion Criteria:

1. American Society of Anesthesiologists (ASA) Physical Status I \& II
2. Patients undergoing limb or breast surgery
3. Patients undergoing elective surgery under general anesthesia and spontaneous ventilation.
4. Patients with expected duration of surgery of less than 2 hours.

Exclusion Criteria:

1. Patients with known or predicted difficult airway or Mallampati Grade (MPG) III or IV
2. Patients with mouth opening of less than 2.5 cm or cervical spine disease
3. Patients with H/o upper respiratory tract infection in the previous 10 days.
4. Patients with increased risk of regurgitation and aspiration (non-fasting patients, gastroesophageal reflux disease etc.)
5. Patients with a body mass index (BMI) \> 30 kg/m2
6. Patients with past history of radiotherapy involving the hypopharynx/neck area 7Patients with expected duration of surgery of more than 2 hours.

8.Surgery to be performed to the head, neck or thorax, abdomen or in the lateral or prone positions

Primary outcomes:
measure: Success rate for the first attempt at insertion
timeFrame: 5 minutes
Secondary outcomes:
measure: Time taken for insertion
timeFrame: 5 minutes
measure: The number of insertion attempts
timeFrame: 5 minutes
measure: Intracuff and the oropharyngeal leak pressures after ensuring effective placement.
timeFrame: 5 minutes
measure: The time taken for orogastric tube placement
timeFrame: 5 minutes
Other outcomes:
Locations:
city: Jamshedpur
country: India
facility: Tata Main Hospital
state: Jharkhand
Study officials:
References:
Clinical trial NCT06459492: Puzzle Game Strategy on Older Adults
Official title: Effect of Puzzle Game Strategy on Cognitive Functioning and Psychological Well-being Among Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Old Age; Debility
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2024-06-14
Enrollment: 70
Sex: ALL
Minimum age (years): 60
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: One innovative approach uses puzzle game strategies, including crosswords, Sudoku, and other brain-teasing activities. These strategies have been shown to help maintain attention, improve memory, and keep older adults' thoughts clear and sharp. Additionally, engaging in these activities can provide psychological benefits by offering a sense of achievement, reducing stress, and fostering social interactions.

Detailed description: Cognitive abilities naturally decline as people age, one factor leading to deteriorating psychological health among older adults. Therefore, it is crucial to develop interventions to enhance this population's cognitive abilities and psychological well-being through non-pharmacological complementary treatments. Such interventions should focus on improving these symptoms while replacing traditional therapies.

One innovative approach uses puzzle game strategies, including crosswords, Sudoku, and other brain-teasing activities. These strategies have been shown to help maintain attention, improve memory, and keep older adults' thoughts clear and sharp. Additionally, engaging in these activities can provide psychological benefits by offering a sense of achievement, reducing stress, and fostering social interactions.

Given puzzle games' potential to enhance cognitive and psychological health, exploring their effectiveness as a non-pharmacological intervention for community-dwelling older adults is essential. This research aims to fill the gap by empirically investigating the impact of puzzle game strategies on cognitive functioning and psychological well-being in this demographic.

Eligibility criteria: Inclusion Criteria:

* Aged 60 years and above.
* Able to communicate effectively.
* Have mild or moderate cognitive impairment,

Exclusion Criteria:

* Have rheumatoid arthritis.
* Hand tremors that could limit their ability to use puzzles.

Primary outcomes:
measure: Older adults who participate in puzzle game strategies and cognitive functioning by Mental Health Scale (MHS)
timeFrame: three months
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Alexandria university
state: Al Iskandariyah
Study officials:
References:
Clinical trial NCT00417092: Biventricular Pacing After Coronary Artery Bypass Grafting (BIVAC)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiac Pacing,Artificial
Coronary Artery Bypass
Ventricular Function, Left
Keywords: coronary artery bypass grafting
reduced left ventricular function
postoperative pacing
cardiac resynchronization
Lead sponsor: University Hospital Schleswig-Holstein
Sponsor class: OTHER
First posted: 2006-12-29
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine which pacing mode after coronary artery bypass grafting in patients with reduced left ventricular function is hemodynamically favorable.

Detailed description: Patients with severely reduced left ventricular function undergoing coronary artery bypass grafting (CABG) are at an increased perioperative risk and often need prolonged postoperative treatment on intensive care units. A significant portion of these patients require postoperative pacing. Right ventricular pacing has been shown to be hemodynamically deleterious whereas biventricular pacing improves cardiac output in patients with severely reduced left ventricular function and bundle branch block. The purpose of this study is to compare DDD-right ventricular, DDD-biventricular and AAI pacing in CABG patients with an ejection fraction less than 40% in a prospective randomized setting.

Eligibility criteria: Inclusion Criteria:

* Elective or urgent coronary artery bypass grafting
* Preoperative ejection fraction less than 40%

Exclusion Criteria:

* Existing permanent pacemaker or ICD
* Concomitant valve surgery
* Preoperative cardiovascular instability requiring intubation or IABP use
* Chronic renal failure requiring dialysis
* Failure to provide informed consent

Primary outcomes:
measure: Duration of Intensive Care Treatment
Secondary outcomes:
measure: 30 day mortality
measure: Major adverse events
measure: Duration of Hospital Stay
measure: Hemodynamic parameters
measure: Inotrope use
measure: Atrial fibrillation
measure: Ventricular tachycardia / ventricular fibrillation
measure: Renal function
measure: Stability of pacing wires
Other outcomes:
Locations:
city: Luebeck
country: Germany
facility: University Hospital Schleswig Holstein, Campus Luebeck, Cardiac Surgery
state: Schleswig Holstein
Study officials:
affiliation: University Hospital Schlesig Holstein, Campus Luebeck, Medicine II, Luebeck, Germany
name: Uwe KH Wiegand, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00712192: Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting
Official title: The Impact on Endothelial Function and Integrity by Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Artery Disease
Keywords: coronary artery bypass grafting
endoscopic vein harvest
saphenous vein
endothelial cells
eNOS
ET-1
Lead sponsor: Far Eastern Memorial Hospital
Sponsor class: OTHER
First posted: 2008-07-09
Enrollment: 34
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Although the long saphenous vein remains the most commonly used conduit in coronary revascularization, traditional open vein harvest may lead to significantly impaired wound healing and post-operative pain. To this end, endoscopic saphenous vein harvesting techniques have been shown to reduce post-operative morbidity. Studies have shown that endothelial integrity and luminal nitric oxide synthase (NOS) are better preserved with novel "no-touch" techniques; however, the effect and the associated mechanism of endoscopic vein harvest on endothelial integrity and function remain unknown. Therefore, in the present proposal, we will collect the saphenous vein segements immediately after harvesting, reperfusion, and grafting, and then use enzyme-linked immunosorbant assay (ELISA), immunohistochemical staining (IHC), and real-time polymerase chain reaction (RT-PCR) to detect the expression and distribution of endothelial NOS (eNOS), endothelin-1 (ET-1), vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), and platelet endothelial cell adhesion molecule-1(PECAM-1) at protein and RNA levels in the endothelium of saphenous veins. The major aim of this study is to elucidate the effect and mechanism of endoscopic saphenous vein harvesting on endothelial properties as compare to conventional open vein harvest technique.


Eligibility criteria: Inclusion Criteria:

* patient with coronary artery disease underwent coronary artery bypass grafting in our hospital

Exclusion Criteria:

* no

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02772692: Defecation Postures for Functional Consumption
Official title: Influence of Defecation Postures on Functional Consumption in Humans
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Constipation
Lead sponsor: Air Force Military Medical University, China
Sponsor class: OTHER
First posted: 2016-05-13
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Whether functional consumption is influenced by defecation postures is unclear. The investigators investigated effects of defecation postures on functional consumption.

Detailed description: Constipation is a chronic problem in many patients all over the world. In some groups of patients such as the elderly, constipation is a significant health care problem. A prospective study was performed at 3 hospitals in China. The included patients were functional consumption patients with defecation sitting on a standard-sized toilet. Patients received standard functional consumption treatment according to the guideline and were randomly assigned to groups that using a squatting pan or a standard-sized toilet.

Eligibility criteria: Inclusion Criteria:

* Subject has functional constipation
* Subject does not receive other treatments

Exclusion Criteria:

* History of heart cerebrovascular disease
* History of other types of constipation
* Pregnant, trying to become pregnant or breast feeding
* Age\< 18-year and \>70-year

Primary outcomes:
measure: Frequency of defecation
timeFrame: Six months
Secondary outcomes:
measure: Frequency of re-defecation after the first defecation
timeFrame: Six months
measure: Defecation time
timeFrame: Six months
measure: Sensation of non-complete defecation
timeFrame: Six months
measure: Straining forces during defecation
timeFrame: Six months
Other outcomes:
Locations:
Study officials:
affiliation: Xijing Hospital
name: Qingchuan Zhao, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Roberts MC, Millikan RC, Galanko JA, Martin C, Sandler RS. Constipation, laxative use, and colon cancer in a North Carolina population. Am J Gastroenterol. 2003 Apr;98(4):857-64. doi: 10.1111/j.1572-0241.2003.07386.x.
citation: Lindberg G, Hamid SS, Malfertheiner P, Thomsen OO, Fernandez LB, Garisch J, Thomson A, Goh KL, Tandon R, Fedail S, Wong BC, Khan AG, Krabshuis JH, LeMair A; World Gastroenterology Organisation. World Gastroenterology Organisation global guideline: Constipation--a global perspective. J Clin Gastroenterol. 2011 Jul;45(6):483-7. doi: 10.1097/MCG.0b013e31820fb914. No abstract available.
citation: Rao SS, Kavlock R, Rao S. Influence of body position and stool characteristics on defecation in humans. Am J Gastroenterol. 2006 Dec;101(12):2790-6. doi: 10.1111/j.1572-0241.2006.00827.x. Epub 2006 Oct 6.
Clinical trial NCT06308692: Molecular Diagnostics of Bacterial Infections and Antibiotic Resistance in Blood Samples and Rectal Swabs Using Real Time PCR-ARES PCR Methods
Official title: Molecular Diagnostics of Bacterial Infections and Antibiotic Resistance in Blood Samples and Rectal Swabs Using Real Time PCR-ARES PCR Methods
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Drug Resistant Bacterial Infection
Lead sponsor: IRCCS Sacro Cuore Don Calabria di Negrar
Sponsor class: OTHER
First posted: 2024-03-13
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Experimental study without drug and device, on pseudo-anonymized samples archived at the Tropica Biobank.

The objective is to evaluate the performance for the identification of microorganisms in blood samples and rectal swabs of real time PCR assays for the targets: KPC, VIM, IMP, NDM, Acinetobacter OXA, Oxa48, MCR.

The evaluations will be carried out taking into consideration the data obtained from the diagnostic routine at the DITM.


Eligibility criteria: Inclusion criteria:

* Samples of patients for whom blood culture and Multi Drug Resistant (MDR) surveillance tests were carried out in rectal swabs at the IRCCS Sacro Cuore Don Calabria Hospital
* Samples for which the Information and consent to the conservation of biological samples for research purposes at the Tropica Biobank has been signed

Exclusion criteria:

* Absence of data relating to positivity or negativity to the germs of interest
* Absence of stored residual material
* Absence of information and consent to the conservation of biological samples for signed research purposes

Primary outcomes:
measure: PCR results
timeFrame: Baseline
Secondary outcomes:
measure: Gene mutations
timeFrame: Baseline
Other outcomes:
Locations:
city: Negrar
country: Italy
facility: IRCCS Sacro Cuore Don Calabria hospital
state: Verona
Study officials:
References:
Clinical trial NCT02786992: Misoprostol+Oxytocin vs. Carbetocin in CS
Official title: Adjuvant Use of Misoprostol and Oxytocin vs. Carbetocin for the Prevention of Post-partum Hemorrhage in Elective Cesarian Section
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Cesarean Section
Keywords: Misoprostol
Oxytocin
Carbetocin
Prevention
Post-partum hemorrhage
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2016-06-01
Enrollment: 600
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This prospective randomized double-blind clinical trial will be conducted at Ain-Shams University Maternity Hospital, Cairo, Egypt. Patients eligible for elective lower segment cesarean section will be randomized to 2 groups. Group 1: will receive 400 ug misoprostol following + 10 IU oxytocin intravenous slowly after cord clamping. Group 2: will receive 100 ug carbetocin intravenous after cord clamping.


Eligibility criteria: Inclusion Criteria:

* Women with singleton pregnancy Women scheduled for elective CS full term (gestational age ≥37 weeks).

Exclusion Criteria:

* hypersensitivity to oxytocin, carbetocin or prostaglandins
* contraindication to prostaglandins (e.g. glaucoma)
* history of significant heart disease
* severe asthma
* epilepsy
* history or evidence of liver
* renal or vascular disease
* history of coagulopathy
* thrombocytopenia or anticoagulant therapy
* women with HELLP syndrome
* eclampsia
* women presenting by placental abruption
* contraindication to spinal anesthesia as carbetocin is licensed for use with regional anesthesia only.

Primary outcomes:
measure: incidence of post-partum hemorrhage
timeFrame: 24 hours
measure: amount of blood loss
timeFrame: 24 hours
Secondary outcomes:
measure: Number of participants needing extra uterotonic drug (10 IU oxytocin IVI)
timeFrame: 24 hours
measure: Number of participants needing hemostatic surgical interventions
timeFrame: intra-operative
measure: Hemoglobin deficit in gm/dl
timeFrame: 24 hours
measure: APGAR score at 1 minute and 5 minutes
timeFrame: 1 minute and 5 minutes
measure: Number of participants with NICU admission
timeFrame: 24 hours
measure: Drug side effects
timeFrame: 24 hours
measure: Time till resuming bowel habits
timeFrame: 24 hours
measure: hematocrit deficit in %
timeFrame: 24 hours
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University Maternity Hospital
Study officials:
References: