Clinical trial NCT05519631: Correlates Between EEG Microstates and Clinical Characteristics of People With Stroke
Official title: Correlates Between EEG Microstates and Clinical Characteristics of People With Stroke
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Stroke
Electroencephalogram
Lead sponsor: Federal University of Paraíba
Sponsor class: OTHER
First posted: 2022-08-29
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The sample consisted of 45 people, 15 individuals with subacute stroke, 15 individuals with chronic stroke and 15 healthy controls, selected for convenience. Stroke subjects were recruited through personal invitations from individuals admitted to a hospital's neurology outpatient clinic.

Individuals matched by sex and age, with no history of neurological or psychiatric diseases, were recruited to the control group.

Brief summary: Stroke has been considered one of the main causes of long-term disability in the adult population, and is no longer considered a disease of the elderly, since 2/3 of all strokes occur among people under 70 years of age. According to the Ministry of Health, stroke is responsible for 40% of early retirements, being one of the most important causes of mortality in Brazil. The electroencephalogram (EEG) has been shown to be a very useful tool in the study of functional status and for the diagnosis of brain damage and disorders. It is considered a simple, non-invasive test with high temporal resolution, being a method widely used in laboratories to non-invasively monitor brain activity.

Detailed description: Stroke has been considered one of the main causes of long-term disability in the adult population, and is no longer considered a disease of the elderly, since 2/3 of all strokes occur among people under 70 years of age. According to the Ministry of Health, stroke is responsible for 40% of early retirements, being one of the most important causes of mortality in Brazil. Stroke usually causes long-term deficits such as asymmetrical muscle weakness between limbs, impaired proprioceptive ability, sensory loss, vision problems, and spasticity. In addition, these sensorimotor deficits interfere with various functions of the lower limbs, including balance, postural control, and gait ability, affecting their quality of life. The electroencephalogram (EEG) has been shown to be a very useful tool in the study of functional status and for the diagnosis of brain damage and disorders. It is considered a simple, non-invasive test with high temporal resolution, being a method widely used in laboratories to non-invasively monitor brain activity. Microstates reflect short periods (\~100 ms) of nearly stable brain states evolving over time, resulting from the synchronous and coordinated activity of brain networks. The aim of this study is to observe whether EEG microstates have correlations with clinical characteristics of people with stroke.

Eligibility criteria: Inclusion Criteria:

* people over 18 years of age, regardless of sex and with a stroke confirmed by computed tomography or magnetic resonance imaging.

Exclusion Criteria:

* have other associated neurological pathology

Primary outcomes:
measure: eeg microstates
timeFrame: Immediately after evaluation
Secondary outcomes:
measure: Relationship between microstates and injury severity
timeFrame: Immediately after evaluation
measure: Relationship between microstates and cognitive function
timeFrame: Immediately after evaluation
Other outcomes:
Locations:
city: Joao Pessoa
country: Brazil
facility: Aging and Neuroscience Studies Laboratory
Study officials:
affiliation: Federal University of Paraiba
name: Suellen Andrade, Dra
role: PRINCIPAL_INVESTIGATOR
References: