Clinical trial NCT03507998: Phase 1 Dose Escalation Study of CGX1321 in Subjects With Advanced Gastrointestinal Tumors
Official title: A Phase 1 Open-label Dose Escalation Study of CGX1321 in Subjects With Advanced Gastrointestinal Tumors
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Colorectal Adenocarcinoma
Gastric Adenocarcinoma
Pancreatic Adenocarcinoma
Bile Duct Carcinoma
Hepatocellular Carcinoma
Esophageal Carcinoma
Gastrointestinal Cancer
Lead sponsor: Curegenix Inc.
Sponsor class: INDUSTRY
Collaborators: name: Guangzhou Curegenix Co. Ltd.
First posted: 2018-04-25
Enrollment: 39
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a multi-center, open label, repeat dose, Phase 1 study consisting of a Dose Escalation Phase and a Dose Expansion Phase to evaluate safety, pharmacokinetics, and clinical activity.

Detailed description: The purpose of the Dose Escalation Phase is to examine the safety and determine the maximum tolerated dose of CGX1321 when administered to subjects with advanced GI tumors that have relapsed or are refractory to or not considered medically suitable to receive standard of care treatment.

Once the dose is identified in the Dose Escalation Phase, the Dose Expansion Phase will start. The purpose of the Dose Expansion Phase is to continue to examine the safety and confirm the final Phase 2 dose of CGX1321 when administered to subjects with advanced GI tumors who meet the entry criteria.

Eligibility criteria: Inclusion Criteria:

* Histologically-diagnosed advanced Gl tumors, such as colorectal adenocarcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma, bile duct carcinoma, hepatocellular carcinoma, esophageal carcinoma that have relapsed or are refractory to or are not considered medically suitable to receive standard of care treatment
* Eastern Cooperative Oncology Group (ECOG) score of 0 - 1
* Minimum estimated life expectancy of 3 months
* Adequate organ function
* Recovery from prior treatment-related toxicities
* Ability to swallow capsules
* Willingness for subjects of reproductive potential to use adequate methods of contraception during and for 3 months after study treatment

Exclusion Criteria:

* Prior exposure to a WNT inhibitor
* Received previous therapy for malignancy within 21 days
* Major surgery within 4 weeks of first dose of study drug
* Radiotherapy within 2 weeks of first dose of study drug
* Significant GI or variceal bleeding or subdural hematoma within 3 months of treatment start
* Uncontrolled central nervous system metastases or leptomeningeal metastases
* Requirement for immunosuppressive agents (must be off for at least 7 days)
* Currently receiving medications that are known CYP3A4/5 inhibitors. Patients currently receiving medications of known inducers of CYP3A4/5 or substrates of CYP2C8/9 and CYP1A2 may be excluded.
* Bone abnormalities
* Hypercalcemia
* Cardiac abnormalities
* Known human immunodeficiency virus positive, or active hepatitis A, B or C
* History of additional prior malignancy with the exception of surgically cured carcinomas such as skin, prostate, bladder, thyroid, cervix or other carcinomas in situ
* Active systemic infection requiring intravenous antibiotics within 2 weeks of treatment start
* Pregnancy or lactation

Primary outcomes:
measure: Number of participants with adverse events and/or abnormal laboratory values that are related to treatment
timeFrame: 21 months
Secondary outcomes:
measure: CGX1321 maximum or peak concentration
timeFrame: 30 days
measure: CGX1321 minimum or trough concentration
timeFrame: 30 days
measure: CGX1321 time to maximum concentration
timeFrame: 30 days
measure: CGX1321 half life
timeFrame: 30 days
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Cancer Hospital
city: Beijing
country: China
facility: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Study officials:
References: