Clinical trial NCT04402996: Meteorin-like Levels in Individuals With Periodontitis
Official title: Evaluation of Meteorin-like Levels in Individuals With Healthy and Periodontal Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Periodontitis
Gingivitis
Healthy
Keywords: Meteorin-like
Lead sponsor: Istanbul Saglik Bilimleri University
Sponsor class: OTHER
First posted: 2020-05-27
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Individuals will be divided into three different groups, about 20-25 people in each group.

Brief summary: Metrnl has proven to be an inflammatory-related immunoregulatory cytokine and shown to play a role in the pathogenesis of human inflammatory diseases. Metrnl is highly expressed from the oral mucosa to the esophagus. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. The authors think that Metrnl may play a role in the periodontitis. The aim of this study is to compare the Metrnl, IL-1β, and IL-10 levels of healthy and periodontitis individuals.

Detailed description: Periodontitis is a destructive chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. Cytokines play an important role in inflammation that occurs in periodontal disease.

Interleukine -1β ( IL-1β ) levels are associated with periodontal destruction in the pathogenesis of periodontal disease. Cytokines such as Interleukine-10 (IL-10) and transforming growth factor- β (TGF-β) have been reported to decrease periodontal disease progression rate.

Gingival crevicular fluid shows the cellular response in the periodontium. The most important host-related ingredients are inflammatory markers, including cytokines, enzymes, and interleukins. Saliva analysis is used in the diagnosis of systemic conditions as well as in the diagnosis of oral pathologies.

Meteorin- like (Metrnl) is a protein that plays a role in natural and acquired immune-related functions and inflammatory responses, and expressed in barrier tissues (skin and mucosa) as well as various macrophage populations, from dendritic cells and some granulocytes. Metrnl has proven to be an inflammatory-related immunoregulatory cytokine and shown to play a role in the pathogenesis of human inflammatory diseases. Metrnl, which is highly expressed from the oral mucosa to the esophagus, may play a role in the onset of periodontitis and an effective marker in preventing the progression of destruction. We think that Metrnl plays an important role in periodontitis, an inflammatory disease. The aim of this study is to compare the Metrnl, IL-1β, and IL-10 levels of healthy and periodontitis individuals

Eligibility criteria: Inclusion Criteria:

* systemically healthy
* individuals who does not have a disease under treatment,
* individuals without regular systemic medication

Exclusion Criteria:

* smoking
* receiving periodontal treatment in the last 6 months
* pregnancy
* menopausal or menstrual period

Primary outcomes:
measure: IL-1β
timeFrame: through study completion, an average of 6 months
measure: Metrnl
timeFrame: through study completion, an average of 6 months
measure: IL-10 levels
timeFrame: through study completion, an average of 6 months
Secondary outcomes:
measure: Plaque Index
timeFrame: up to 20 weeks
measure: Probing Depth
timeFrame: up to 20 weeks
measure: Bleeding on Probe
timeFrame: up to 20 weeks
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Ebru Sağlam
state: Eyalet/Yerleşke
Study officials:
affiliation: Saglik Bilimleri Universitesi
name: Ayşe Toraman, Dr.
role: STUDY_CHAIR
affiliation: Saglik Bilimleri Universitesi
name: Serhat Köseoğlu, assoc prof
role: STUDY_CHAIR
affiliation: Izmir Katip Celebi University
name: Mehmet Sağlam, assoc prof
role: STUDY_CHAIR
affiliation: Izmir Katip Celebi University
name: Levent Savran, PhD
role: STUDY_CHAIR
affiliation: Saglik Bilimleri Universitesi
name: Ebru Sağlam, Dr
role: PRINCIPAL_INVESTIGATOR
References: