Clinical trial NCT04561622: Emotional Proactive Processing in Bipolar Disorder
Official title: Emotional Proactive Processing in Bipolar Disorder
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Bipolar Disorder
Bipolar I Disorder
Bipolar II Disorder
Keywords: bipolar disorder
emotion
cognition
stroop
proactive emotional processing
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2020-09-23
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: bipolar patients cohort followed-up in the Expert Center of University Hospital of Grenoble

Brief summary: The main objective of this project is to identify behavioral specificities of the proactive emotional brain among bipolar patients, compared to healthy subjects. These could contribute to some of the emotional processing biases that can be observed in these patients. To achieve this goal, two behavioral tasks will be administer (emotional stroop and emotional stimuli categorization task) to bipolar patients and control subjects, and their performances will be compared.

Detailed description: This is a case-control non-interventional study comparing bipolar patients to matched healthy controls during one assessment visit at the University Hospital of Grenoble.

The experimentation phase takes place in three stages: first, the experimenter collects demographic data (age and level of study, lack of medical history and treatments that may interfere with the task). For bipolar subjects, it also collects the type of bipolarity, the type and date of the last episode, the age of the onset of the disease and the treatment.

Secondly, the subject performs a classic Stroop task lasting 3 to 5 minutes, including instructions.

Finally, the subject performs the two main tasks: the emotional Stroop task lasting about 20 minutes and then the task of emotional stimuli categorization lasting about 15 minutes.

Eligibility criteria: Inclusion Criteria:

* Right-handed
* Francophones
* Bipolar disorder diagnosis (for patients) according to DSM-5 / CIM-10 criteria
* Affiliation to the French social security insurance

Exclusion Criteria:

* uncorrected perceptual disturbance
* psychiatric disorders other than bipolarity as the main psychiatric disorder or a condition which may affect the tasks proposed for the patients' group
* subject under legal protection
* subject deprived of freedoms by a judicial or administrative decision
* drug abuse less than 12 hours before the assessment

Primary outcomes:
measure: performances at the emotional Stroop task
timeFrame: day1
Secondary outcomes:
measure: sensitivity to interference during Stroop tasks
timeFrame: day1
measure: Effect of mood state (depressive state) on behavioral tasks' performances
timeFrame: day 1
measure: Effect of mood state (hypo/manic state) on behavioral tasks' performances
timeFrame: day 1
Other outcomes:
Locations:
city: La Tronche
country: France
facility: CHU Grenoble Alpes
state: Isère
Study officials:
affiliation: University Hospital, Grenoble
name: Mircea Polosan, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Beffara B, Wicker B, Vermeulen N, Ouellet M, Bret A, Molina MJ, Mermillod M. Reduction of interference effect by low spatial frequency information priming in an emotional Stroop task. J Vis. 2015;15(6):16. doi: 10.1167/15.6.16.
citation: Golden, C. (1978). Diagnosis and Rehabilitation in Clinical Neuropsychology. College of Psychology: Faculty Books and Book Chapters. https://nsuworks.nova.edu/cps_facbooks/48