Clinical trial NCT00699998: A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects
Official title: A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects With Unstable Angina/Non-ST-Elevation Myocardial Infarction Who Are Medically Managed
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Acute Coronary Syndrome
Keywords: ACS
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
Collaborators: name: Daiichi Sankyo Co., Ltd.
name: Duke Clinical Research Institute
First posted: 2008-06-18
Enrollment: 9326
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will evaluate the relative efficacy and safety of prasugrel and clopidogrel in a medically managed Unstable Angina/Non-ST-Elevation Myocardial Infarction (UA/NSTEMI) acute coronary syndrome (ACS) population (that is, patients who are not managed with acute coronary revascularization).

Detailed description: Based upon the significant number of subjects with UA/NSTEMI ACS who are managed medically and their high risk for future cardiovascular events, further exploration of novel treatment strategies for this population, who are under-represented in large clinical trials, is warranted. Potential subjects will be those with a recent UA/NSTEMI event who are to be medically managed. Eligibility for this study will be determined by both the timing of the medical management decision and by prior commercial clopidogrel treatment at the time of randomization. The TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) Study will assess the efficacy and safety of prasugrel and aspirin compared to the current standard of care, clopidogrel and aspirin, for long-term treatment of medically managed UA/NSTEMI ACS subjects.

Eligibility criteria: Key Inclusion Criteria:

* Have had a Unstable Angina/Non-ST-Elevation Myocardial Infarction (UA/NSTEMI) index event within 10 days prior to randomization
* Had a medical management strategy decision made with reasonable certainty that neither percutaneous coronary intervention (PCI) nor coronary artery bypass graft (CABG) is planned for treatment of the index event
* Had at least 1 of 4 specified high-risk features at the time of the UA/NSTEMI event

Key Exclusion Criteria:

* Decision for medical management greater than 72 hours after onset of index event without commercial clopidogrel treatment within 72 hours following onset of the index event.
* Insignificant coronary artery disease (CAD) on coronary angiography if performed for Index Event (absence of greater than or equal to 30% stenosis in at least one native vessel)
* Previous or planned PCI or CABG as treatment for the index event
* PCI/CABG within previous 30 days
* ST-segment elevation myocardial infarction (STEMI) as the index event
* Cardiogenic shock, Refractory ventricular arrhythmias, New York Heart Association (NYHA) Class IV congestive heart failure (CHF) within the previous 24 hours
* History of ischemic or hemorrhagic stroke, transient ischemic attack (TIA), Intracranial neoplasm, arteriovenous malformation, or aneurysm
* History of spontaneous gastrointestinal (GI) or non-GI bleeding requiring hospitalization for treatment, unless definitive treatment has occurred and there is low likelihood of recurrence
* Hemodialysis or peritoneal dialysis

Primary outcomes:
measure: Percentage of Participants With a Composite Endpoint of Cardiovascular (CV) Death, Myocardial Infarction (MI), or Stroke
timeFrame: Randomization through end of study (30-month visit)
Secondary outcomes:
measure: Percentage of Participants With a Composite Endpoint of CV Death and MI
timeFrame: Randomization through end of study (30-month visit)
measure: Percentage of Participants With a Composite Endpoint of CV Death, MI, Stroke, or Re-hospitalization for Recurrent Unstable Angina (UA)
timeFrame: Randomization through end of study (30-month visit)
measure: Percentage of Participants With a Composite Endpoint of All-cause Death, MI, or Stroke
timeFrame: Randomization through end of study (30-month visit)
measure: Platelet Aggregation Measures
timeFrame: Day 30 and 12 Months
measure: Biomarker Measurements of Inflammation/Hemodynamic Stress: Brain Natriuretic Peptide (BNP)
timeFrame: Day 30 and 6 Months
measure: Biomarker Measurements of Inflammation/Hemodynamic Stress: C-Reactive Protein (CRP)
timeFrame: Day 30 and Month 6
measure: Genotyping Related to Drug Metabolism
timeFrame: Baseline
measure: Economic and Quality of Life Outcomes
timeFrame: Baseline and follow-up (24 months)
measure: Summary of All Deaths
timeFrame: Randomization through end of study (30-month visit)
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Alabama
city: Huntsville
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Alabama
city: Glendale
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Arizona
city: Tucson
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Arizona
city: Fort Smith
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Arkansas
city: Anaheim
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: California
city: Banning
country: United States
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state: California
city: Bellflower
country: United States
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state: California
city: Healdsburg
country: United States
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state: California
city: Lancaster
country: United States
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state: California
city: Long Beach
country: United States
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state: California
city: Los Angeles
country: United States
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state: California
city: Mather
country: United States
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state: California
city: Newport Beach
country: United States
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state: California
city: Palo Alto
country: United States
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state: California
city: Sacramento
country: United States
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state: California
city: San Diego
country: United States
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state: California
city: Sylmar
country: United States
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state: California
city: Yuba City
country: United States
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state: California
city: Colorado Springs
country: United States
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state: Colorado
city: Denver
country: United States
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state: Colorado
city: Loveland
country: United States
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state: Colorado
city: Wheat Ridge
country: United States
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state: Colorado
city: Washington
country: United States
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state: District of Columbia
city: Atlantis
country: United States
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state: Florida
city: Aventura
country: United States
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state: Florida
city: Boynton Beach
country: United States
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state: Florida
city: Brandon
country: United States
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state: Florida
city: Deerfield Beach
country: United States
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state: Florida
city: Hudson
country: United States
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state: Florida
city: Lakeland
country: United States
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state: Florida
city: Melbourne
country: United States
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state: Florida
city: Miami
country: United States
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state: Florida
city: Orlando
country: United States
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state: Florida
city: Ormond Beach
country: United States
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state: Florida
city: Panama City
country: United States
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state: Florida
city: Pensacola
country: United States
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state: Florida
city: Port Charlotte
country: United States
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state: Florida
city: Sarasota
country: United States
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state: Florida
city: Tallahassee
country: United States
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state: Florida
city: Tampa
country: United States
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state: Florida
city: Trinity
country: United States
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state: Florida
city: West Palm Beach
country: United States
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state: Florida
city: Atlanta
country: United States
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state: Georgia
city: Covington
country: United States
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state: Georgia
city: Decatur
country: United States
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state: Georgia
city: Riverdale
country: United States
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state: Georgia
city: Savannah
country: United States
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state: Georgia
city: Melrose Park
country: United States
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state: Illinois
city: Peoria
country: United States
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state: Illinois
city: Rock Island
country: United States
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state: Illinois
city: Anderson
country: United States
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state: Indiana
city: Elkhart
country: United States
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state: Indiana
city: Hammond
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Indiana
city: Indianapolis
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Indiana
city: Muncie
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Indiana
city: Valparaiso
country: United States
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state: Indiana
city: Ames
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Iowa
city: Louisville
country: United States
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state: Kentucky
city: Alexandria
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Louisiana
city: Baton Rouge
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Louisiana
city: Covington
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Louisiana
city: Lake Charles
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Louisiana
city: Natchitoches
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Louisiana
city: New Orleans
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Louisiana
city: Baltimore
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Maryland
city: Salisbury
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Maryland
city: Boston
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Massachusetts
city: Fall River
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Massachusetts
city: Bay City
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Michigan
city: Flint
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Michigan
city: Minneapolis
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Minnesota
city: Picayune
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Mississippi
city: Columbia
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Missouri
city: Kansas City
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Missouri
city: St Louis
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Missouri
city: Kalispell
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Montana
city: Omaha
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Nebraska
city: Las Vegas
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Nevada
city: Nashua
country: United States
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state: New Hampshire
city: Bridgewater
country: United States
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state: New Jersey
city: Cherry Hill
country: United States
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state: New Jersey
city: Flemington
country: United States
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state: New Jersey
city: Ridgewood
country: United States
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state: New Jersey
city: Bronx
country: United States
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state: New York
city: Brooklyn
country: United States
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state: New York
city: Buffalo
country: United States
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state: New York
city: Flushing
country: United States
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state: New York
city: New Hartford
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state: New York
city: New York
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state: New York
city: Syracuse
country: United States
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state: New York
city: Chapel Hill
country: United States
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state: North Carolina
city: Charlotte
country: United States
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state: North Carolina
city: Elizabeth City
country: United States
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state: North Carolina
city: Gastonia
country: United States
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state: North Carolina
city: Hickory
country: United States
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state: North Carolina
city: Lenoir
country: United States
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state: North Carolina
city: Matthews
country: United States
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state: North Carolina
city: Pinehurst
country: United States
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state: North Carolina
city: Salisbury
country: United States
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state: North Carolina
city: Sanford
country: United States
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state: North Carolina
city: Statesville
country: United States
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state: North Carolina
city: Wilmington
country: United States
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state: North Carolina
city: Winston Salem
country: United States
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state: North Carolina
city: Cincinnati
country: United States
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state: Ohio
city: Cleveland
country: United States
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state: Ohio
city: Mansfield
country: United States
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state: Ohio
city: Toledo
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state: Ohio
city: Zanesville
country: United States
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state: Ohio
city: Muskogee
country: United States
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state: Oklahoma
city: Oklahoma City
country: United States
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state: Oklahoma
city: Tulsa
country: United States
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state: Oklahoma
city: Hillsboro
country: United States
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state: Oregon
city: Portland
country: United States
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state: Oregon
city: Abington
country: United States
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state: Pennsylvania
city: Bethlehem
country: United States
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state: Pennsylvania
city: Chambersburg
country: United States
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state: Pennsylvania
city: Clarks Summit
country: United States
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state: Pennsylvania
city: Doylestown
country: United States
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state: Pennsylvania
city: Erie
country: United States
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state: Pennsylvania
city: Greensburg
country: United States
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state: Pennsylvania
city: Harrisburg
country: United States
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state: Pennsylvania
city: Pittsburgh
country: United States
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state: Pennsylvania
city: Pottstown
country: United States
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state: Pennsylvania
city: Sayre
country: United States
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state: Pennsylvania
city: Sellersville
country: United States
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state: Pennsylvania
city: West Chester
country: United States
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state: Pennsylvania
city: Wormleysburg
country: United States
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state: Pennsylvania
city: Charleston
country: United States
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state: South Carolina
city: Rock Hill
country: United States
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city: Rapid City
country: United States
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city: Sioux Falls
country: United States
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state: South Dakota
city: Chattanooga
country: United States
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state: Tennessee
city: Germantown
country: United States
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state: Tennessee
city: Hendersonville
country: United States
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state: Tennessee
city: Jackson
country: United States
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state: Tennessee
city: Johnson City
country: United States
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state: Tennessee
city: Knoxville
country: United States
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state: Tennessee
city: Lexington
country: United States
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state: Tennessee
city: Memphis
country: United States
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state: Tennessee
city: Oak Ridge
country: United States
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state: Tennessee
city: Amarillo
country: United States
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city: Austin
country: United States
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city: Corpus Christi
country: United States
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city: Edinburg
country: United States
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city: Fort Sam Houston
country: United States
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city: Houston
country: United States
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city: Lackland Afb
country: United States
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city: San Antonio
country: United States
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state: Texas
city: Victoria
country: United States
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city: American Fork
country: United States
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city: Salt Lake City
country: United States
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city: Charlottesville
country: United States
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city: Danville
country: United States
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state: Virginia
city: Hopewell
country: United States
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city: Lake Ridge
country: United States
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state: Virginia
city: Manassas
country: United States
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state: Virginia
city: Newport News
country: United States
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state: Virginia
city: Richmond
country: United States
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state: Virginia
city: Roanoke
country: United States
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state: Virginia
city: Seattle
country: United States
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state: Washington
city: Spokane
country: United States
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state: Washington
city: Tacoma
country: United States
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state: Washington
city: Burlington
country: United States
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state: Wisconsin
city: Milwaukee
country: United States
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state: Wisconsin
city: Bahia Blanca
country: Argentina
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city: Buenos Aires
country: Argentina
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city: Caba
country: Argentina
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city: Concordia
country: Argentina
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city: Corrientes
country: Argentina
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city: Córdoba
country: Argentina
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city: Formosa
country: Argentina
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city: Godoy Cruz
country: Argentina
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city: La Plata
country: Argentina
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city: Mar Del Plata
country: Argentina
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city: Moron
country: Argentina
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city: Rosario
country: Argentina
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city: Salta
country: Argentina
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city: San Luis
country: Argentina
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city: San Miguel De Tucuman
country: Argentina
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city: Santa Fe
country: Argentina
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city: Villa Cabrera
country: Argentina
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city: Villa Maria
country: Argentina
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city: Coffs Harbour
country: Australia
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state: New South Wales
city: Lismore
country: Australia
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state: New South Wales
city: Newcastle
country: Australia
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state: New South Wales
city: Wollongong
country: Australia
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state: New South Wales
city: Herston
country: Australia
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state: Queensland
city: Nambour
country: Australia
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state: Queensland
city: Redcliffe
country: Australia
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state: Queensland
city: Southport
country: Australia
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state: Queensland
city: Bedford Park
country: Australia
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state: South Australia
city: Elizabeth Vale
country: Australia
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state: South Australia
city: Hobart
country: Australia
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state: Tasmania
city: Feldkirch
country: Austria
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city: Vienna
country: Austria
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city: Brussels
country: Belgium
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city: Huy
country: Belgium
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city: Liège
country: Belgium
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city: Mol
country: Belgium
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city: Overpelt
country: Belgium
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city: Aracaju
country: Brazil
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city: Belo Horizonte
country: Brazil
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city: Blumenau
country: Brazil
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city: Brasilia
country: Brazil
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city: Campina Grande Do Sul
country: Brazil
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city: Campinas
country: Brazil
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city: Campo Grande
country: Brazil
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city: Caxias Do Sul
country: Brazil
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city: Curitiba
country: Brazil
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city: Dois Lajeados
country: Brazil
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city: Goiania
country: Brazil
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city: Maceio
country: Brazil
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city: Maringa
country: Brazil
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city: Passo Fundo
country: Brazil
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city: Piracicaba
country: Brazil
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city: Porto Alegre
country: Brazil
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city: Recife
country: Brazil
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city: Ribeirao Preto
country: Brazil
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city: Rio De Janeiro
country: Brazil
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city: Salvador
country: Brazil
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city: Santo Andre
country: Brazil
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city: Sao Caetano Do Sul
country: Brazil
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city: Sao Jose Rio Preto
country: Brazil
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city: Sao Jose
country: Brazil
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city: São Paulo
country: Brazil
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city: Uberlandia
country: Brazil
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city: Votuporanga
country: Brazil
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city: Dimitrovgrad
country: Bulgaria
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city: Haskovo
country: Bulgaria
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city: Kazanlak
country: Bulgaria
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city: Kjustendil
country: Bulgaria
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city: Pazardzhik
country: Bulgaria
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city: Pleven
country: Bulgaria
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city: Plovdiv
country: Bulgaria
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city: Rousse
country: Bulgaria
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city: Sofia
country: Bulgaria
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city: Varna
country: Bulgaria
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city: Edmonton
country: Canada
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state: Alberta
city: Campbell River
country: Canada
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state: British Columbia
city: St Johns
country: Canada
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state: Newfoundland and Labrador
city: Halifax
country: Canada
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state: Nova Scotia
city: Ajax
country: Canada
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state: Ontario
city: Burlington
country: Canada
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state: Ontario
city: Cambridge
country: Canada
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state: Ontario
city: London
country: Canada
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state: Ontario
city: Oshawa
country: Canada
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state: Ontario
city: Sarnia
country: Canada
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state: Ontario
city: Scarborough
country: Canada
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state: Ontario
city: Sudbury
country: Canada
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state: Ontario
city: Montreal
country: Canada
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state: Quebec
city: Sainte-Foy
country: Canada
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state: Quebec
city: La Serena
country: Chile
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city: Osorno
country: Chile
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city: Puente Alto
country: Chile
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city: Rancagua
country: Chile
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city: Santiago
country: Chile
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city: Temuco
country: Chile
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city: Vina Del Mar
country: Chile
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city: Beijing
country: China
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city: Bejing
country: China
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city: Changsha
country: China
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city: Fuzhou
country: China
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city: Guang Zhou
country: China
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city: Hangzhou
country: China
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city: Harbin
country: China
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city: Jiangsu
country: China
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city: Nanchang
country: China
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city: Nanjing
country: China
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city: Shanghai
country: China
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city: Shaoguan
country: China
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city: Shengyang
country: China
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city: Shenyang
country: China
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city: Shijiazhuang
country: China
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city: Suzhou City
country: China
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city: Wenzhou
country: China
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city: Wu Han
country: China
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city: Wuhan City
country: China
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city: Xian
country: China
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city: Xuzhou
country: China
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city: Zhengzhou
country: China
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city: Armenia-Quindio
country: Colombia
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city: Barranquilla
country: Colombia
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city: Bogota
country: Colombia
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city: Cali
country: Colombia
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city: Floridablanca
country: Colombia
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city: Medellin
country: Colombia
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city: San Jose
country: Costa Rica
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city: Dubrovnik
country: Croatia
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city: Karlovac
country: Croatia
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city: Koprivnica
country: Croatia
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city: Krapinske Toplice
country: Croatia
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city: Rijeka
country: Croatia
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city: Slavonski Brod
country: Croatia
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city: Split
country: Croatia
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city: Varazdin
country: Croatia
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city: Zadar
country: Croatia
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city: Zagreb
country: Croatia
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city: Decin
country: Czech Republic
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city: Frydek-Mistek
country: Czech Republic
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city: Hradec Kralove
country: Czech Republic
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city: Karlovy Vary
country: Czech Republic
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city: Kromeriz
country: Czech Republic
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city: Liberec
country: Czech Republic
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city: Novy Jicin
country: Czech Republic
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city: Pardubice
country: Czech Republic
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city: Prague
country: Czech Republic
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city: Zlin
country: Czech Republic
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city: Copenhagen
country: Denmark
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city: Hellerup
country: Denmark
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city: Kobenhavn
country: Denmark
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city: Alexandria
country: Egypt
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city: Beni Sweif
country: Egypt
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city: Cairo
country: Egypt
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city: Ismailia
country: Egypt
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city: Menoufiya
country: Egypt
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city: Jyvaskyla
country: Finland
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city: Angers
country: France
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city: Arras
country: France
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city: Besancon
country: France
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city: Cambrai
country: France
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city: Chartres Cedex
country: France
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city: Dijon
country: France
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city: Douai
country: France
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city: La Roche Sur Yon
country: France
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city: Lagny Sur Marne
country: France
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city: Nantes
country: France
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city: Nice
country: France
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city: Paris
country: France
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city: Pessac
country: France
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city: Poitiers
country: France
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city: Strasbourg
country: France
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city: Toulouse
country: France
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city: Valenciennes
country: France
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city: Vandoeuvre Les Nancy
country: France
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city: Bad Nauheim
country: Germany
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city: Darmstadt
country: Germany
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city: Dortmund
country: Germany
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city: Frankfurt
country: Germany
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city: Halle
country: Germany
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city: Idar-Oberstein
country: Germany
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city: Köln
country: Germany
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city: Leipzig
country: Germany
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city: Mainz
country: Germany
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city: Mannheim
country: Germany
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city: Stuttgart
country: Germany
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city: Tuebingen
country: Germany
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city: Athens
country: Greece
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city: Haidari/Athens
country: Greece
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city: Kallithea
country: Greece
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city: Magoula
country: Greece
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city: Patras
country: Greece
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city: Rhodos
country: Greece
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city: Trikala
country: Greece
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city: Baja
country: Hungary
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city: Bekescsaba
country: Hungary
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city: Budapest
country: Hungary
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city: Kalocsa
country: Hungary
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city: Kecskemet
country: Hungary
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city: Komarom
country: Hungary
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city: Miskolc
country: Hungary
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city: Satoraljaujhely
country: Hungary
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city: Sopron
country: Hungary
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city: Szekszard
country: Hungary
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city: Zalaegerszeg
country: Hungary
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city: Ahmedabad
country: India
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city: Anand
country: India
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city: Aurangabad
country: India
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city: Bangalore
country: India
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city: Baramati
country: India
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city: Bikaner
country: India
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city: Calicut
country: India
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city: Chidambaram
country: India
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city: Cochin
country: India
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city: Coimbatore
country: India
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city: Ernakulam
country: India
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city: Guntur
country: India
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city: Gurgaon
country: India
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city: Hyderabaad
country: India
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city: Indore
country: India
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city: Jaipur
country: India
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city: Jalandhar
country: India
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city: Kolkata
country: India
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city: Kottayam
country: India
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city: Lucknow
country: India
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city: Madurai
country: India
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city: Mumbai
country: India
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city: Mysore
country: India
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city: Nagpur
country: India
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city: Nashik
country: India
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city: New Delhi
country: India
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city: Patiala
country: India
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city: Pune
country: India
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city: Saket
country: India
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city: Secunderabad
country: India
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city: Shivamogga
country: India
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city: Solapur
country: India
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city: Surat
country: India
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city: Thrissur
country: India
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city: Tirupati
country: India
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city: Trivandrum
country: India
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city: Vadodara
country: India
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city: Vijayawada
country: India
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city: Visakhapatnam
country: India
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city: Dublin
country: Ireland
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city: Galway
country: Ireland
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city: Afula
country: Israel
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city: Ashkelon
country: Israel
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city: Beer Sheva
country: Israel
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city: Eilat
country: Israel
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city: Haifa
country: Israel
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city: Jerusalem
country: Israel
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city: Kfar Saba
country: Israel
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city: Nahariya
country: Israel
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city: Nazareth
country: Israel
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city: Rehovot
country: Israel
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city: Tel Aviv
country: Israel
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city: Tel Hashomer
country: Israel
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city: Tiberias
country: Israel
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city: Tzfat
country: Israel
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city: Albano Laziale
country: Italy
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city: Ascoli Piceno
country: Italy
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city: Bari
country: Italy
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city: Bergamo
country: Italy
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city: Brescia
country: Italy
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city: Caserta
country: Italy
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city: Forli
country: Italy
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city: Lecco
country: Italy
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city: Legnago
country: Italy
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city: Legnano
country: Italy
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city: Milano
country: Italy
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city: Novara
country: Italy
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city: Parma
country: Italy
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city: Perugia
country: Italy
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city: Pescara
country: Italy
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city: Reggio Emilia
country: Italy
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city: Rimini
country: Italy
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city: Rome
country: Italy
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city: San Daniele Del Friuli
country: Italy
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city: Santa Maria Capua Vetere
country: Italy
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city: Saronno
country: Italy
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city: Sorrento
country: Italy
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city: Terni
country: Italy
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city: Trieste
country: Italy
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city: Busan
country: Korea, Republic of
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city: Daegu
country: Korea, Republic of
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city: Daejeon
country: Korea, Republic of
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city: Gangwon-Do
country: Korea, Republic of
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city: Gwangju
country: Korea, Republic of
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city: Incheon
country: Korea, Republic of
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city: Jeon Ju-City
country: Korea, Republic of
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city: Jin-Ju-Si
country: Korea, Republic of
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city: Seoul
country: Korea, Republic of
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city: Ulsan-Si
country: Korea, Republic of
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city: Kaunas
country: Lithuania
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city: Klaipeda
country: Lithuania
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city: Siauliai
country: Lithuania
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city: Vilnius
country: Lithuania
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city: Cheras, Kuala Lumpur
country: Malaysia
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city: Johor Bahru
country: Malaysia
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city: Kelantan
country: Malaysia
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city: Kuala Lumpur
country: Malaysia
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city: Kuantan Pahang
country: Malaysia
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city: Perak
country: Malaysia
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city: Sarawak
country: Malaysia
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city: Selangor
country: Malaysia
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city: Taiping Perak
country: Malaysia
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city: Gozo
country: Malta
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city: Msida
country: Malta
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city: Aguascalientes
country: Mexico
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city: Culiacan
country: Mexico
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city: Durango
country: Mexico
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city: Jalisco
country: Mexico
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city: Leon
country: Mexico
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city: Monterrey
country: Mexico
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city: Puebla
country: Mexico
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city: Queretaro
country: Mexico
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city: San Luis Potosi
country: Mexico
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city: Tijuana
country: Mexico
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city: Alkmaar
country: Netherlands
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city: Almelo
country: Netherlands
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city: Amsterdam
country: Netherlands
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city: Apeldoorn
country: Netherlands
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city: Beverwijk
country: Netherlands
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city: Blaricum
country: Netherlands
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city: Delft
country: Netherlands
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city: Ede
country: Netherlands
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city: Eindhoven
country: Netherlands
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city: Gouda
country: Netherlands
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city: Hoorn
country: Netherlands
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city: Leeuwarden
country: Netherlands
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city: Leiden
country: Netherlands
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city: Leiderdorp
country: Netherlands
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city: Meppel
country: Netherlands
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city: Oss
country: Netherlands
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city: Roosendaal
country: Netherlands
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city: Venlo
country: Netherlands
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city: Auckland
country: New Zealand
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city: Christchurch
country: New Zealand
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city: Nelson
country: New Zealand
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city: Wellington
country: New Zealand
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city: Cocle
country: Panama
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city: David
country: Panama
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city: Panama
country: Panama
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city: Arequipa
country: Peru
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city: Callao
country: Peru
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city: Cuzco
country: Peru
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city: Lima
country: Peru
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city: Cagayan De De Oro
country: Philippines
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city: Cavite City
country: Philippines
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city: Davao City
country: Philippines
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city: Iloilo City
country: Philippines
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city: Manila
country: Philippines
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city: Marikina City
country: Philippines
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city: Metro Manila
country: Philippines
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city: Pasig City
country: Philippines
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city: Quezon City
country: Philippines
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city: Quezon City
country: Philippines
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city: Bydgoszcz
country: Poland
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city: Elblag
country: Poland
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city: Gdansk
country: Poland
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city: Katowice
country: Poland
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city: Koszalin
country: Poland
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city: Krakow
country: Poland
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city: Kutno
country: Poland
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city: Lodz
country: Poland
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city: Lubin
country: Poland
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city: Lublin
country: Poland
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city: Myslenice
country: Poland
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city: Nowy Sacz
country: Poland
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city: Olawa
country: Poland
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city: Piotrkow Trybunalski
country: Poland
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city: Pulawy
country: Poland
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city: Ruda Slaska
country: Poland
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city: Skierniewice
country: Poland
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city: Szczecin
country: Poland
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city: Walbrzych
country: Poland
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city: Warsaw
country: Poland
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city: Wejherowo
country: Poland
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city: Wroclaw
country: Poland
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city: Aveiro
country: Portugal
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city: Carnaxide
country: Portugal
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city: Coimbra
country: Portugal
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city: Leiria
country: Portugal
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city: Ponta Delgada
country: Portugal
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city: Santarem
country: Portugal
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city: Setubal
country: Portugal
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city: Vila Franca De Xira
country: Portugal
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city: Caguas
country: Puerto Rico
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city: Mayaguez
country: Puerto Rico
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city: San Juan
country: Puerto Rico
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city: Bacau
country: Romania
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city: Baia Mare
country: Romania
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city: Braila
country: Romania
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city: Brasov
country: Romania
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city: Bucharest
country: Romania
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city: Buzau
country: Romania
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city: Cluj-Napoca
country: Romania
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city: Focsani
country: Romania
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city: Pitesti
country: Romania
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city: Suceava
country: Romania
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city: Targoviste
country: Romania
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city: Arkhangelsk
country: Russian Federation
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city: Gatchina
country: Russian Federation
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city: Kazan
country: Russian Federation
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city: Kemerovo
country: Russian Federation
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city: Krasnoyarsk
country: Russian Federation
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city: Moscow
country: Russian Federation
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city: Nizhny Novgorod
country: Russian Federation
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city: Novokuznetsk
country: Russian Federation
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city: Novosibirsk
country: Russian Federation
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city: Omsk
country: Russian Federation
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city: Rostov-On-Don
country: Russian Federation
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city: Saint Petersburg
country: Russian Federation
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city: Saratov
country: Russian Federation
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city: Tomsk
country: Russian Federation
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city: Tyumen
country: Russian Federation
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city: Belgrade
country: Serbia
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city: Kragujevac
country: Serbia
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city: Niska Banja
country: Serbia
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city: Nis
country: Serbia
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city: Zemun
country: Serbia
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city: Singapore
country: Singapore
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city: Bratislava
country: Slovakia
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city: Levice
country: Slovakia
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city: Martin
country: Slovakia
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city: Nitra
country: Slovakia
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city: Nove Zamky
country: Slovakia
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city: Presov
country: Slovakia
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city: Ruzomberok
country: Slovakia
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city: Zilina
country: Slovakia
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city: Alberton
country: South Africa
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city: Bloemfontein
country: South Africa
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city: Cape Town
country: South Africa
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city: Durban
country: South Africa
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city: George
country: South Africa
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city: Johannesburg
country: South Africa
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city: Parktown West
country: South Africa
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city: Somerset West
country: South Africa
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city: Worcester
country: South Africa
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city: Barcelona
country: Spain
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city: Gerona
country: Spain
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city: Málaga
country: Spain
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city: Palma De Mallorca
country: Spain
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city: Reus
country: Spain
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city: San Boi De Llobregat
country: Spain
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city: Sevilla
country: Spain
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city: Valencia
country: Spain
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city: Bollnas
country: Sweden
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city: Karlstad
country: Sweden
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city: Lund
country: Sweden
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city: Bellinzona
country: Switzerland
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city: Winterthur
country: Switzerland
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city: Kaohsiung
country: Taiwan
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city: Taipei
country: Taiwan
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city: Bangkok
country: Thailand
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city: Chiang Mai
country: Thailand
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city: Khon Kaen
country: Thailand
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city: Nakhon Ratchasima
country: Thailand
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city: Pathumthani
country: Thailand
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city: Udon Thani
country: Thailand
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city: La Marsa
country: Tunisia
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city: Menzel Bourguiba
country: Tunisia
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city: Monastir
country: Tunisia
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city: Sfax
country: Tunisia
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city: Sousse
country: Tunisia
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city: Tunis Monfleury
country: Tunisia
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city: Tunis
country: Tunisia
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city: Adana
country: Turkey
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city: Ankara
country: Turkey
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city: Bolu
country: Turkey
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city: Bursa
country: Turkey
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city: Edirne
country: Turkey
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city: Erzurum
country: Turkey
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city: Isparta
country: Turkey
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city: Istanbul
country: Turkey
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city: Kocaeli
country: Turkey
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city: Konya
country: Turkey
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city: Kırıkkale
country: Turkey
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city: Samsun
country: Turkey
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city: Trabzon
country: Turkey
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city: Cherkasy
country: Ukraine
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city: Dnipropetrovsk
country: Ukraine
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city: Donetsk
country: Ukraine
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city: Ivano-Frankivsk
country: Ukraine
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city: Kharkiv
country: Ukraine
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city: Kiev
country: Ukraine
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city: Kryvyy Rig
country: Ukraine
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city: Kyiv
country: Ukraine
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city: Lugansk
country: Ukraine
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city: Lutsk
country: Ukraine
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city: Lviv
country: Ukraine
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city: Mykolayiv
country: Ukraine
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city: Odesa
country: Ukraine
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city: Poltava
country: Ukraine
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city: Simferopol
country: Ukraine
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city: Vinnytsya
country: Ukraine
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city: Zaporozhye
country: Ukraine
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city: Stockton-On-Tees
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Cleveland
city: Torquay
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Cnwll
city: Durham
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: County Durham
city: Chesterfield
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Derbyshire
city: Plymouth
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Devon
city: Brighton
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: East Sussex
city: Cottingham
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: East Yorkshire
city: Colchester
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Essex
city: Romford
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Essex
city: London
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Greater London
city: Southall
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Greater London
city: Newport
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Gwent
city: Portsmouth
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Hampshire
city: Orpington
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Kent
city: Lincoln
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Lincolnshire
city: Wirral
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Merseyside
city: York
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: North Yorkshire
city: Nottingham
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Nottinghamshire
city: Yeovil
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Somerset
city: Dundee
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Tays
city: Nuneaton
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Warwickshire
city: Warwick
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: Warwickshire
city: Livingston
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: West Lothian
city: Birmingham
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: West Midlands
city: Dudley
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: West Midlands
city: West Bromwich
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: West Midlands
city: Wolverhampton
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: West Midlands
city: Bradford
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: West Yorkshire
city: Northampton
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
city: Sunderland
country: United Kingdom
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Study officials:
affiliation: Eli Lilly and Company
name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UC/GMT - 5 hours, EST)
role: STUDY_DIRECTOR
References:
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