louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04632004: Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health
Official title: Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dry Mouth
Halitosis
Lead sponsor: University of Göttingen
Sponsor class: OTHER
First posted: 2020-11-17
Enrollment: 3750
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Patients, visitors, and staff members of the University Medical Center Goettingen are invited to participate within the survey study.
Primary purpose: PREVENTION

Brief summary: During the current COVID-19 pandemic, the use of face masks is recommended / mandatory to prevent infection. Patients and students have reported to experience limitations in their oral health-related quality of life, especially with regard to the occurrence of dry mouth and halitosis, while wearing face masks.

Scientific studies regarding the effects of face masks have so far focused exclusively on medical staff. Studies among the general population are not yet available, but are of interest as dry mouth is a risk factor for dental diseases (e.g., caries, erosion).

Therefore, the present study aims at performing a questionnaire survey regarding self-perceived dry mouth and halitosis and the use of face masks (type, wearing time).


Eligibility criteria: Inclusion Criteria:

* Patients, visitors, and staff members of the University Medical Center Goettingen

Exclusion Criteria:

* N/A

Primary outcomes:
measure: Self-perceived dry mouth
timeFrame: During the 1 day of questionnaire survey
measure: Self-perceived halitosis
timeFrame: During the 1 day of questionnaire survey
Secondary outcomes:
Other outcomes:
Locations:
city: Göttingen
country: Germany
facility: University Medical Center Goettingen, Dept. of Preventive Dentistry, Periodontology and Cariology
state: Lower Saxony
Study officials:
References:
citation: Farronato M, Boccalari E, Del Rosso E, Lanteri V, Mulder R, Maspero C. A Scoping Review of Respirator Literature and a Survey among Dental Professionals. Int J Environ Res Public Health. 2020 Aug 17;17(16):5968. doi: 10.3390/ijerph17165968.
citation: Rebmann T, Carrico R, Wang J. Physiologic and other effects and compliance with long-term respirator use among medical intensive care unit nurses. Am J Infect Control. 2013 Dec;41(12):1218-23. doi: 10.1016/j.ajic.2013.02.017. Epub 2013 Jun 12.
citation: Shenal BV, Radonovich LJ Jr, Cheng J, Hodgson M, Bender BS. Discomfort and exertion associated with prolonged wear of respiratory protection in a health care setting. J Occup Environ Hyg. 2012;9(1):59-64. doi: 10.1080/15459624.2012.635133.
citation: Kanzow P, Dylla V, Mahler AM, Hrasky V, Rodig T, Barre F, Scheithauer S, Wiegand A. COVID-19 Pandemic: Effect of Different Face Masks on Self-Perceived Dry Mouth and Halitosis. Int J Environ Res Public Health. 2021 Aug 31;18(17):9180. doi: 10.3390/ijerph18179180.
Clinical trial NCT05896904: Clinical Comparison of Patients With Transthyretin Cardiac Amyloidosis and Patients With Heart Failure With Reduced Ejection Fraction
Official title: Clinical Comparison of Patients With Transthyretin Cardiac Amyloidosis and Patients With Heart Failure With Reduced Ejection Fraction
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Transthyretin Amyloid Cardiomyopathy
Heart Failure
Keywords: Heart Failure
Echocardiography
Lead sponsor: Aarhus University Hospital Skejby
Sponsor class: OTHER
First posted: 2023-06-09
Enrollment: 100
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: Clinical comparison of patients with transthyretin cardiac amyloidosis and patients with heart failure with reduced ejection fraction


Eligibility criteria: Inclusion Criteria:

* Age \>65
* ATTRwt diagnosis for patients, either with DPD-scintigraphy or myocardiac biopsy
* informed consent

Exclusion Criteria:

* Alder \<65
* No ATTRwt diagnosis

Primary outcomes:
measure: intraventricular wall thickness
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Aarhus
country: Denmark
facility: Aarhus University Hospital
Study officials:
affiliation: Clinic of heart diseases, AUH.
name: Valentin R Klarskov, Bachelor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04765904: Clinical Efficiency and Treatment Failure of Hall Versus SDF Techniques in the Management of Carious Primary Molar.
Official title: Clinical Efficiency and Treatment Failure of Hall Versus SDF Techniques in the Management of Carious Primary Molar: Randomized Clinical Trial.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Early Childhood Caries
Keywords: hall technique
Silver diamide fluoride
non invasive technique
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2021-02-23
Enrollment: 120
Sex: ALL
Minimum age (years): 4
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will compare two non- invasive treatment options: Hall technique and 38% Silver diamine fluoride. Both are methods used to create a more favorable environment without removal of caries leading to the arrest of the progression of demineralization process and restoring the function of the diseased molars.

Detailed description: Detailed Description:

Dental caries, also known as tooth decay, it can occur in primary teeth in early childhood, is formed through interaction between acid-producing bacteria and carbohydrate. The caries develops in both the crowns and roots of teeth. Progress of caries depended on the lifestyle of the child (as high numbers of cariogenic bacteria, inadequate salivary flow, insufficient fluoride exposure and poor oral hygiene). To avoid this disease should follow the proper oral hygiene and improve lifestyle . A lot of methods found to treatment the decayed tooth - like; Hall technique and Silver diamine fluoride The first report on the Hall Technique published in 2007 by a general dental practitioner from Aberdeen/Scotland, Dr. Norna Hall. Dr. Hall used PMCs to restore carious primary molars rather than using the standard technique, placed them using a simplified method2

Previous studies have recommended that Silver diamine fluoride (SDF) solution would exert a preventive result in managing early childhood caries ECC. However, no well-designed clinical trials have yet been performed to study the effect of SDF on caries prevention. the objective is useful in arresting early childhood caries (ECC)

Eligibility criteria: Inclusion Criteria:

* Age: From 4 to 6 years
* Caries in primary molars within enamel/dentin without pulp disease

Exclusion Criteria:

* Presence of signs and symptoms of necrosis
* Root caries
* Spontaneous pain

Primary outcomes:
measure: percentage of Treatment failure:
timeFrame: one year
Secondary outcomes:
measure: Canine overbite
timeFrame: one year
measure: Arresting caries in SDF
timeFrame: one year
Other outcomes:
Locations:
Study officials:
affiliation: Cairo University
name: Gihan Abuelniel, professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT01978704: Glycaemic Load and Pre-meal Insulin Doses in Type 1 Diabetes Patients
Official title: Use of the Glycemic Load for the Adjustment of the Dose of Preprandial Insulin in Patients With Type 1 Diabetes Mellitus in Insulin Pump Therapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Type 1 Diabetes
Lead sponsor: Federico II University
Sponsor class: OTHER
First posted: 2013-11-07
Enrollment: 9
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The aim of this study is to compare the feasibility and the efficacy on short-term glucose control of pre-meal insulin doses adjustment made on the bases of the glycemic load or of the carbohydrates content of the meal in patients with type 1 diabetes mellitus treated with insulin pump


Eligibility criteria: Inclusion Criteria:

* Type 1 diabetes treated by insulin pump

Exclusion Criteria:

* Preganncy
* HbA1c \> 9%

  * Any serious acute or chronic illness a part diabetes

Primary outcomes:
measure: daily plasma glucose excursion
timeFrame: 1 week
measure: mean plasma glucose concentrations
timeFrame: 1 week
Secondary outcomes:
measure: postprandial plasma glucose concentrations
timeFrame: 1 week
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02949804: Relation Between Vasovagal Tendency and Smoking Among University Students
Official title: Relation Between Vasovagal Tendency and Smoking Among University Students
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Vasovagal Syncope
Smoke Inhalation
Lead sponsor: Jordan Collaborating Cardiology Group
Sponsor class: OTHER
First posted: 2016-10-31
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Students at the university or college

Brief summary: Almost everyone is aware these days is aware about the risk of smoking. Still many people start this habit specially in early life and during college year. We aim to investigate in this study if there is a drive to smoke in people with vasovagal tendency to improve their symptoms, even if not aware of this. Vasovoagal symptoms are common and include dizziness, smoking, sweating, abdominal pain, fatigue and syncope. Some studies have shown correlation between smoking and a positive tilt table test which is indicative of vasovagal tendency. By collecting the information regarding smoking habit and vasovagal symptoms analysis can be done to see if there is correlation between these two factors

Detailed description: Methods

A questionnaire will be conducted among university students to investigate the tendency toward vasovagal symptoms and also smoking habits. Statistical correlation will be subsequently conducted to see if there is correlation between those two problems (vasovagal symptoms and smoking)

Study criteria inclusion

Benefit to the patient:

There is no direct benefit for participation in the study. The information obtained may help in the future to find factors that increase smoking and being aware of these factors may help in controlling the habit of smoking.

Eligibility criteria: Inclusion Criteria:

* College students who agree to participate in the questionnaire

Exclusion Criteria:

* Unable or does not consent to fill the form

Primary outcomes:
measure: Incidence of vasovagal tenancy in smokers and non smokers
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Amman
country: Jordan
facility: Istishari hospital
Study officials:
affiliation: Jordan Collaborating Cardiology Group
name: Munir Al Zaqqa, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04232501: Radial, Sequential Compression Device Deep Venous Thrombosis Detection Study
Official title: Effect of Novel Sequential Compression Device on the Incidence of Deep Venous Thrombosis on Complex Surgical Spine Patients
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Deep Venous Thrombosis
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2020-01-18
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to evaluate the effectiveness of a new leg compression device in preventing post-surgical deep vein thrombosis (blood clot) that can occur after major and complex spine surgery. The investigators aim to show that this new compression device is no worse than the standard sequential compression device (SCD) at preventing DVT and may be able to detect deep vein thrombosis in patients who are not typically screened for this diagnosis after surgery. This new device may be able to capture an important post-surgical complication while providing a more comfortable treatment option.

Detailed description: Compression therapy of the leg is a proven and well-established modality to prevent deep vein thrombosis in immobilized and post-surgical patients. The investigators aim to compare a new sequential compression for the leg that utilizes a servo motor for compression as opposed to a traditional pneumatic motor that is typically used in the hospital and after surgery. Pneumatic sequential compression devices are cumbersome, expensive and not mobile. This new compression device was developed to provide a cheaper, mobile device that can be worn by the patient after surgery and while at home during ambulation. The addition of the servo motor and fine sensors may also be able to detect sub-clinical DVT's that contribute to post-surgical pulmonary embolus and post-surgical complications. The investigators aim to learn how this new device performs in the subset of patients undergoing complex spine surgery, the incidence of post-surgical DVT with this new device compared to traditional SCD and if this new device is capable of detecting sub-clinical post-surgical DVT.

Eligibility criteria: Inclusion Criteria:

* Patients scheduled for complex spine surgery at Stanford Hospital

Exclusion Criteria:

* Pregnancy
* Non-decisional capacity
* Incarcerated persons
* Any hereditary or acquired coagulopathy

Primary outcomes:
measure: Incidence of Deep Vein Thrombosis (DVT)
timeFrame: Within four weeks after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford Hospital and Clinics
state: California
Study officials:
affiliation: Stanford University
name: Adam Schlifke
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05242601: Investigation of Quality of Life in Adolescent Idiopathic Scoliosis
Official title: Investigation of Quality of Life in Adolescent Idiopathic Scoliosis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis
Lead sponsor: Kirsehir Ahi Evran Universitesi
Sponsor class: OTHER
First posted: 2022-02-16
Enrollment: 28
Sex: ALL
Minimum age (years): 10
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: volunteered for the study participants were diagnosed with adolescent idiopathic scoliosis,

Brief summary: the aim of our study is to identify independent predictors of quality of life in AIS.

Detailed description: Adolescent idiopathic scoliosis (AIS) is the lateral and horizontal deformity of the columna vertebralis which occurs idiopathically in adolescence ages. The aim of this study is to identify independent predictors of quality of life in AIS

Eligibility criteria: Inclusion Criteria:

* volunteered for the study participants were diagnosed with adolescent idiopathic scoliosis,
* between ages 10-18
* Cobb angle between 10-30 degrees
* Lenke curve type 1

Exclusion Criteria:

* non-idiopathic scoliosis,
* who had exercise contraindications
* who had previous spinal surgery
* who had orthotic treatment for scoliosis before
* who had exercise contraindications
* who had another neuromuscular
* who had cardiopulmonary and rheumateulogical problem

Primary outcomes:
measure: Investigation of Quality of Life in Adolescent Idiopathic Scoliosis
timeFrame: 4 week
Secondary outcomes:
Other outcomes:
Locations:
city: Kırşehir
country: Turkey
facility: Kırşehir Ahi Evran University
Study officials:
References:
citation: Kaya MH, Erbahceci F, Alkan H, Kocaman H, Buyukturan B, Canli M, Buyukturan O. Factors influencing of quality of life in adolescent idiopathic scoliosis. Musculoskelet Sci Pract. 2022 Dec;62:102628. doi: 10.1016/j.msksp.2022.102628. Epub 2022 Jul 19.
Clinical trial NCT06784401: Oncologic and Functional Outcome and Quality of Life in Patients Treated for Laryngeal Cancer
Official title: Oncologic and Functional Outcome and Quality of Life in Patients Treated for Laryngeal Cancer. (Original Title in Italian Language: "Il Trattamento Del Carcinoma Laringeo: Outcome Oncologico, Funzionale e Quality of Life")
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Laryngeal Cancer
Lead sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sponsor class: OTHER
First posted: 2025-01-20
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults (\>= 18 years) of both sexes treated and followed for laryngeal cancer at the Department of Otollaryngology and Audiology of the University Hospital of Bologna.

Brief summary: The goal of this observational study is to learn about oncologic and functional outcome and investigate quality of life in patients treated for laryngeal cancer.

Detailed description: Adult (\>=18 years of age) patients treated by surgery and/or radiation therapy are enrolled retrospectively.

The main question it aims to answer is:

Is voice after total laryngectomy with voice prosthesis better than voice after open partial horizzontal laryngectomy? Subjective and objective scales and parameters are used.

Eligibility criteria: Inclusion Criteria:

* Patients treated for laryngeal cancer diagnosed by histopathologic examination

Exclusion Criteria:

* Patients lost at follow up
* Age \< 18 years

Primary outcomes:
measure: Oncologic and functional outcome in patients treated for laryngeal cancer.
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: Quality of life in patients treated for laryngeal cancer.
timeFrame: through study completion, an average of 1 year
Other outcomes:
Locations:
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study officials:
affiliation: IRCCS Azienda Ospedaliero-Universitaria di Bologna
name: Cecilia Botti, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02710201: A Randomized-controlled Trial of Social Norm Interventions to Increase Physical Activity
Official title: A Randomized-controlled Trial of Social Norm Interventions to Increase Physical Activity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physical Activity
Lead sponsor: University of California, Merced
Sponsor class: OTHER
First posted: 2016-03-16
Enrollment: 111
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: BASIC_SCIENCE

Brief summary: Objective: Physical activity confers numerous health benefits, yet few adults meet recommended physical activity guidelines. The impact of brief messages providing feedback on physical activity was tested in this study. Methods: Young adults were randomly assigned to one of three conditions: (1) feedback on how active others were, (2) feedback on how active others were plus a message of approval or disapproval depending on whether the participant was more or less active than average, or (3) no feedback (control condition). Participants used pedometers for eight weekdays and recorded their step counts each evening. The group receiving feedback on how active others were got information about the average number of steps taken by group members the previous day. The group that also received approval or disapproval received feedback about the group average, as well as a sad face if the participant was below the average or a happy face if the participant was above the average. The control group received no feedback throughout the study. Impacts of these feedback messages were compared on number of steps taken during the study.


Eligibility criteria: Inclusion Criteria:

* Age 18 or older

Exclusion Criteria:

* Answering yes to any questions on the Physical Activity Readiness Questionnaire.

Primary outcomes:
measure: Number of steps
timeFrame: Two weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Wally CM, Cameron LD. A Randomized-Controlled Trial of Social Norm Interventions to Increase Physical Activity. Ann Behav Med. 2017 Oct;51(5):642-651. doi: 10.1007/s12160-017-9887-z.
Clinical trial NCT02546401: Comparison of Insulin's Injection Before or After the Meal in Type 1 Diabetic Patients Treated With Insulin Pump
Official title: Comparison of Injection of an Analogue Bolus of Insulin Before or After the Meal in Type 1 Diabetic Patients Treated With Insulin Pump.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Diabetes Type 1
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2015-09-10
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The current study focuses on terms of use of Insulin Aspart, fast analogue of human insulin and commonly used in the treatment of type 1 diabetes, where it obtained the marketing authorization for this indication. In the patient who have an insulin pump, insulin Aspart is given daily like a pre-prandial bolus (just before the meal). However, many patients perform their bolus after the meal. However this insulin administration modality is not clearly studied in the literature.

Detailed description: The functional insulin therapy is a method for adjusting insulin doses which tends to mimic the physiology, especially when food intake with proportional dose calculation to the amount of carbohydrates ingested by the use of ratios. This method of adaptation, increasingly used in France, is an extension in the use of subcutaneous insulin pump with a more precise determination of bolus doses with meals, and use of aids dose calculations (assistant wizard for instance). In practice every day, some patients perform their bolus immediately after eating, not just before, allowing them to know exactly the amount of ingested carbohydrates and not the one provided in advance.

This study is very interesting because it allows to compare the injection of an analogous bolus of fast insulin before and after the meal.

Eligibility criteria: Inclusion Criteria:

* Major patients with type 1 diabetes treated with insulin pump.

Exclusion Criteria:

* Unbalanced diabetes,
* Ongoing pregnancy known,
* Gastrointestinal neuropathy known,
* Chronic medical illness and psychiatric

Primary outcomes:
measure: Area Under Curve (AUC) of glycemia
timeFrame: During 14 days
Secondary outcomes:
measure: Mean Amplitude of Glycemic excursions (MAGE) = measure of glycemia instability
timeFrame: During 14 days
measure: Area Under Curve (AUC) during 4H after a high-fat meal
timeFrame: 4 hours
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU Brest
Study officials:
References: