louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06901804: Effect of Pilates Core Stabilization in Adjunct With Plyometric Shoulder Training on Low Back Pain in Fast Bowlers(RCT)
Official title: Effect of Pilates Core Stabilization in Adjunct With Plyometric Shoulder Training on Low Back Pain in Fast Bowlers: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Low Back Pain
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2025-03-30
Enrollment: 36
Sex: ALL
Minimum age (years): 17
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This RCT will seek to determine both the Pilates core stabilization and plyometric shoulder training on LBP in fast bowlers. The research problem will emphasize the absence of detailed rehabilitation protocols that address the upper and lower limb strength dysfunction, pain, quality of life, and biomechanics of fast bowlers. Prior literature has not examined the combined use of these two training interventions to address LBP, which affects the performance of fast bowlers. In this study, participants will be randomly assigned to two groups. Group A (experimental) will receive Pilates core stabilization and plyometric shoulder training, while Group B (control) will receive conventional physiotherapy for LBP. There will be two sessions per week for six weeks, and the intensity of the exercises will gradually increase to address athletes' strength, flexibility, and movement control.

Detailed description: Assessments will be conducted using multiple scales of upper limb strength for the Cricket Ball Throw Test, lower limb strength for the Vertical Jump Test, Quality of Life for the Oswestry Disability Index, biomechanics analysis to determine movement efficiency and Pain Intensity for Numeric Pain Rating Scale. This study will give information about the efficiency of adding core and shoulder training to managing LBP in fast bowlers, increasing their athletic performance and bringing helpful value to the sports and physiotherapy domain.

Eligibility criteria: Inclusion Criteria:

* Age between 17-25 years
* Male cricket players
* Playing cricket for more than 2 years
* Low back pain without radiation
* Chronic low back pain for more than 3 months
* Non-specific mechanical type without identifiable specific anatomical or neurophysiological causative factors and medically fit

Exclusion Criteria:

* Any pathological condition of the spine, hip, knee, and pelvis.
* Any history of musculoskeletal injury in the past 6 months.
* Any history of a neurological condition.
* Uncontrolled metabolic disorders such as Diabetes Mellitus
* Any surgical h/o shoulder or elbow in the past 6 months

Primary outcomes:
measure: NPRS (Numeric Pain Rating Scale)
timeFrame: 12 Months
measure: CBTT (Cricket Ball Throw Test)
timeFrame: 12 months
measure: VJT (Vertical Jump Test)
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Pakistan Cricket Board
state: Punjab
Study officials:
References:
Clinical trial NCT05158504: The Effect of Motivational Messages on Emergency Nurses
Official title: The Effects of Motivational Messages Sent to Emergency Nurses During the COVID-19 Pandemic on Job Satisfaction, Compassion Fatigue, and Communication Skills: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Satisfaction
Compassion Fatigue
Communication, Social
Lead sponsor: Istanbul Saglik Bilimleri University
Sponsor class: OTHER
First posted: 2021-12-15
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Aim and objectives: The aim of this study is to examine the effect of motivational notifications applied to emergency nurses on job satisfaction, compassion fatigue and communication skills during the COVID-19 pandemic.

Background: Emergency room nurses working on the front lines during the COVID-19 pandemic; many factors such as excessive workload, prolonged working hours, threat of infection, death of the patients they care for have caused them to experience physical, social and psychological problems.

Design: It is a randomized controlled, open-label study. Methods: This study was carried out with a total of 60 nurses working in the emergency units of two training and research hospitals in Istanbul. Participants were divided into motivational group and control group. Motivational notifications were sent via Short Message Service (SMS) to the mobile phones of the participants in the motivational group (n=30) for 21 days. No motivational notification was sent to the control group (n=30) during this process. Data were obtained with the Individual Introduction Form, Job Satisfaction, Compassion Fatigue and Communication Skills Scale.


Eligibility criteria: Inclusion Criteria:The nurses working in the emergency room, working only in the day shift on weekdays, using mobile phones and volunteering to participate in the study were included in the study.

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Exclusion Criteria: Exclusion criteria for the study included being on leave for any reason (maternity, annual, medical) during the study dates, not completely filling in the data collection forms, or withdrawing from the study.

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Primary outcomes:
measure: Job Satisfaction-Short Scale
timeFrame: Baseline and after 3 weeks
measure: Compassion Fatigue-Short Scale
timeFrame: Baseline and after 3 weeks
measure: Communication Skills Scale
timeFrame: Baseline and after 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Hilal KARTAL
state: Beylikdüzü
Study officials:
References:
Clinical trial NCT05752604: Impact of Conventional Treatments and Clinical Variables on Thyroid Cancer
Official title: Retrospective and Prospective Evaluation of the Impact of Innovative and Conventional Treatments and of Clinical Variables on the Outcome of Thyroid Cancer
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Thyroid Cancer
Lead sponsor: Istituto Auxologico Italiano
Sponsor class: OTHER
First posted: 2023-03-02
Enrollment: 3000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: all consecutive patients referred to our tertiary clinical center for thyroid cancer

Brief summary: DTC has a generally favorable prognosis. The possibility to discriminate between patients with aggressive tumors and those with a more indolent behavior may reduce the need for unnecessary treatments. Aim of this observational study is to evaluate how anamnestic, clinical, and histopathological variables may influence the outcome of the enrolled patients, both regarding morbidity and mortality and in terms of therapeutic choices. The study aims to evaluate the prognostic impact of the therapeutic interventions in terms of efficacy and regarding the appearance of adverse events.


Eligibility criteria: Inclusion Criteria:

- thyroid cancer diagnosis

Exclusion Criteria:

* patients unable to sign informed consent

Primary outcomes:
measure: Dynamic risk stratification
timeFrame: one year from the primary treatment
measure: Dynamic risk stratification
timeFrame: five years from the primary treatment
measure: Dynamic risk stratification
timeFrame: ten years from the primary treatment
measure: Progression-free survival
timeFrame: one year from the primary treatment
measure: Progression-free survival
timeFrame: five years from the primary treatment
measure: Progression-free survival
timeFrame: ten years from the primary treatment
measure: Overall survival
timeFrame: one year from the primary treatment
measure: Overall survival
timeFrame: five years from the primary treatment
measure: Overall survival
timeFrame: ten years from the primary treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Milan
country: Italy
facility: Istituto Auxologico Italiano, IRCCS
Study officials:
References:
Clinical trial NCT02865304: The Efficacy and Safety of Endostar Combined With Taxane-based Regimens for HER-2-negative MBC Patients
Official title: The Efficacy and Safety of Endostar Combined With Taxane-based Regimens for HER-2-negative Metastatic Breast Cancer Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Angiogenesis
Breast Cancer
Keywords: metastatic breast cancer
HER-2-negative
endostar
Lead sponsor: Fujian Cancer Hospital
Sponsor class: OTHER_GOV
First posted: 2016-08-12
Enrollment: 80
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of the present study was to prospectively evaluate the efficacy and safety of endostar, a recombinant product of endostatin, combined with taxane-based regimens for HER-2 negative metastatic breast cancer (MBC) patients.

Detailed description: Endostar is a recombinant product of endostatin, which is an endogenous inhibitor of angiogenesis. Animal studies have shown that endostatin is capable of blocking the proliferation and organization of endothelial cells into new blood vessels in vitro and inhibiting angiogenesis and growth of both primary tumors and secondary metastasis. Regarding breast cancer, in vivo studies showed that the combination of paclitaxel and P125A-endostatin inhibited mammary cancer growth, delayed the onset of multifocal mammary adenocarcinomas, decreased tumor angiogenesis, increased the survival of treated mice in the prevention model, and inhibited lung and lymph node metastasis in the intervention model. Moreover, in a prospective, randomized, controlled, phase II neoadjuvant trial, the combination of rh-endostatin with chemotherapy produced a higher tumor response rate without increasing toxicity in breast cancer patients. Considering these promising data, this prospective study was conducted to evaluate the efficacy and safety of endostar combined with taxane-based regimens for HER-2-negative MBC patients.

Eligibility criteria: Inclusion Criteria:

* women with ages between 18-70 years with histologically confirmed MBC documented as HER-2-negative

Exclusion Criteria:

* cannot tolerated chemotherapy
* cardiac insufficiency

Primary outcomes:
measure: overall response rate
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Department of Medical Oncology, Fujian Provincial Cancer Hospital, The Teaching Hospital of Fujian Medical University, The Teaching Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350014, China
name: weiwei huang, doctor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06939504: A Trial of HRS-9813 Capsule and Tablet in Healthy Subjects
Official title: Evaluation of the Relative Bioavailability of HRS-9813 Capsule and Tablet in Healthy Subjects and the Effect of Food on the Pharmacokinetics of HRS-9813 Capsule
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE1
Conditions: Pulmonary Fibrosis
Lead sponsor: Guangdong Hengrui Pharmaceutical Co., Ltd
Sponsor class: INDUSTRY
First posted: 2025-04-22
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This is a phase Ⅰ study to evaluate the relative bioavailability of HRS-9813 capsule and tablet in healthy subjects and the effect of food on the pharmacokinetics of HRS-9813 capsule.


Eligibility criteria: Inclusion Criteria:

1. Aged 18-45 years.
2. Male weight ≥ 50 kg, female weight ≥ 45 kg, and body mass index (BMI): 19-26 kg/m2.
3. Subjects not with clinically significant vital signs and laboratory tests.
4. Take contraception measures.

Exclusion Criteria:

1. Any serious clinical diseases that affect the absorption, metabolism and/or excretion of the study drug.
2. Severe infection, severe trauma or major surgery.
3. Any medications in the two weeks before screening or baseline period.
4. History of blood donation or severe blood loss.
5. Have been vaccinated within 2 weeks before the screening or baseline period.
6. History of smoking or excessive alcohol or drug abuse.
7. Other situations that the researcher judges to be unsuitable.

Primary outcomes:
measure: Maximum observed concentration of HRS-9813 capsule (Cmax)
timeFrame: Day 1-Day 23.
measure: Maximum observed concentration of HRS-9813 tablet (Cmax)
timeFrame: Day 1-Day 23.
measure: Area under the concentration-time curve from time 0 to infinity of HRS-9813 tablet (AUC0-inf)
timeFrame: Day 1-Day 23.
measure: Area under the concentration-time curve from time 0 to infinity of HRS-9813 capsule (AUC0-inf)
timeFrame: Day 1-Day 23.
Secondary outcomes:
measure: Adverse events (AEs)
timeFrame: Day 1-Day 23.
measure: Time to Cmax of HRS-9813 capsule (Tmax).
timeFrame: Day 1-Day 23.
measure: Time to Cmax of HRS-9813 tablet (Tmax).
timeFrame: Day 1-Day 23.
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
state: Shanghai
Study officials:
References:
Clinical trial NCT03122704: Group B Streptococcus (GBS) Infection and in Preterm Labor Women Conceived Through IVF
Official title: Prevalence of Group B Streptococcus Infection in Pregnant Women Conceived Through IVF Diagnosed With Preterm Labor.
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Preterm Labor
Lead sponsor: Vietnam National University
Sponsor class: OTHER
First posted: 2017-04-21
Enrollment: 0
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: This is a cross - sectional study to determine the prevalence of GBS infection and associated factors in preterm labor women conceived through ART.

221 subjects will be involved.

Detailed description: Pregnant women at 20 0/7 to 36 6/7 weeks of gestation, conceived through ART, with signs and symptoms of preterm labor will be recruited.

Anal - vaginal fluid samples will be taken by 2 cotton swabs from each participant for culture. Digital examination will be performed after that. Only participants fulfilling all the study's eligible criteria will be interviewed face-to-face with a questionnaire.

The samples will be sent immediately to My Duc hospital laboratory or will be stored in Stuart-Amies medium in \< 4 hours. All culture results are interpreted based on Clinical and Laboratory Standards Institute (CLSI) in 2012.

Statistical analysis was performed by Statistical Package for the Social Sciences (SPSS) v.20 and chi-square test. A p-value of \< 0.05 was considered as statistically significant.

Eligibility criteria: \* Inclusion Criteria:

To be eligible for enrolment into this trial, subject must fulfil all of the following criteria, unless specified otherwise

* Being conceived through IVF
* Moderate uterine contractions (2 contractions per 10 minutes, duration \< 30 seconds)
* 20 0/7 to 36 6/7 weeks of gestation
* Intact membrane
* Cervical dilation ≤ 3 cm
* Willing to participate into the study

  * Exclusion Criteria:

To be eligible for enrolment in this study each subject must not meet any of the following criteria:

* Having had intercourse during 24 hours before
* Being suspected of amniotic leakage
* Rupture of membrane identified by direct observation through speculum examination of amniotic fluid flow from cervix
* Vaginal bleeding
* Being suspected of placenta abruption, placenta previa
* Having been treated with antibiotics within 1 week before
* Vaginal douche within 48 hours before
* Having used vaginal medicines during 48 hours before
* Having vaginal ultrasound shortly before
* Urine culture positive with GBS

Primary outcomes:
measure: Percentage of women with GBS infection
timeFrame: 7 days after swab taken
Secondary outcomes:
Other outcomes:
Locations:
city: Ho Chi Minh City
country: Vietnam
facility: My Duc Hospital
state: Tan Binh District
Study officials:
affiliation: Research Center for Genetics and Reproductive Health
name: Tuong M Ho, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT04266704: Building a Multidisciplinary Research Program to Address Hypertension Disparities: Exploring the Neurocognitive Mechanisms of a Self-Management Intervention for African American Women
Official title: Building a Multidisciplinary Research Program to Address Hypertension Disparities: Exploring the Neurocognitive Mechanisms of a Self-Management Intervention for African American Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Lead sponsor: University of Michigan
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2020-02-12
Enrollment: 50
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The goal of this project is to develop and pilot test a research protocol to assess the influence of a health information behavior enhanced intervention on self-management, blood pressure control, and brain activity in African American women with hypertension. This work will identify characteristics of African American women that are associated with improved self-management and decreased blood pressure, and subsequent reduction of risk of heart disease and premature death. The results of this project will have direct impact in informing interventions to improve blood pressure control, by advancing our knowledge of brain activity associated with behavior change in African American women with hypertension in the metro-Detroit area, and ultimately everywhere.


Eligibility criteria: Inclusion Criteria: Inclusion criteria are (a) aged \>18, (b) clinically diagnosed with hypertension, and (c) right-handed (due to potential differences in brain morphology compared to left-handed individuals).

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Exclusion Criteria: Exclusion criteria are (a) history of renal insufficiency, (b) score less than 22 on the Montreal Cognitive Assessment (MOCA), and (c) having one of the following contraindications for fMRI: heart pacemaker, heart defibrillator, metal in the eye, and some types of metal elsewhere within the body such as certain surgical clips for aneurysms in the head, heart valve prostheses, electrodes, and some other implanted devices, pregnant. We require a score of \>22 on the MOCA to assure that subjects are able to participate cognitive procedures.

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Primary outcomes:
measure: Brain activity
timeFrame: 6 months
Secondary outcomes:
measure: Blood pressure
timeFrame: Baseline and 6 months
measure: Quality of life-PROMIS
timeFrame: Baseline and 6 months
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan School of Nursing
state: Michigan
Study officials:
References:
Clinical trial NCT05738304: Ureteral Stenting After Retrograde Intrarenal Surgery for Renal Stones
Official title: One-Day External Ureteral Catheter Versus Double-J Internal Ureteral Stent After Retrograde Intrarenal Surgery for Renal Stones: A Prospective, Randomized Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Kidney Stone
Retrograde Intrarenal Surgery
Ureteral Stent
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2023-02-22
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Several studies evaluated the benefit of a short-term external ureteral catheter (UC) compared to double-J (DJ) ureteral stent after flexible ureteroscopy (URS); the results were controversial. These studies had combined analyses of ureteral and renal stones with a high risk of selection bias. Studies comparing external UC and DJ stent after flexible URS for isolated renal stones are lacking.

In the present study, the investigators will compare the outcomes of using a one-day external UC versus a DJ internal ureteral stent for ureteral drainage after retrograde flexible URS (retrograde intrarenal surgery "RIRS") for renal stones. The investigators aim to identify the best ureteral drainage method after RIRS regarding stone clearance, complications, and stent-related symptoms.


Eligibility criteria: Inclusion Criteria:

• Adult patients of either gender in whom RIRS was the primary modality.

Exclusion Criteria:

* Pregnant women
* Active urinary tract infection
* solitary kidney
* Concomitant pathology that need intervention in the same setting
* Patients with surgical incidents that indicate double-J stenting (Residual sizable fragments, ureteral false passage, ureteral mucosal laceration, ureteral perforation, and calyceal rupture).

Primary outcomes:
measure: Stone free rate
timeFrame: up to 1 month
measure: Stent-related symptoms
timeFrame: from post operative day one till double J removal; an average of 2 weeks
Secondary outcomes:
measure: Postoperative renal pain
timeFrame: up to 1 month
measure: Rehospitalization rate
timeFrame: From post RIRS home discharge up to one month
measure: Reintervention rate
timeFrame: up to 3 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Urology Department, Al-Azhar University Hospital
Study officials:
References: