Clinical trial NCT06055335: Assessing Lung Dynamics and Respiratory Functions in Minimal Flow Anesthesia: A Prospective Study
Official title: EVALUATION OF LUNG DYNAMICS AND RESPIRATORY FUNCTIONS IN PATIENTS APPLIED WITH MINIMAL FLOW ANESTHESIA: A PROSPECTIVE, RANDOMIZED STUDY
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Medium Flow Anesthesia
Minimal Flow Anesthesia
Pulmonary Function Test
Compliance, Patient
Peak Inspiratuar Pressure
Lead sponsor: Ataturk University
Sponsor class: OTHER
First posted: 2023-09-26
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: The patients were randomized into two groups medium flow anesthesia (MeFA) and minimal flow anesthesia (MiFA). While MeFA received medium flow anesthesia with 2 lt/min, MiFA received minimal flow anesthesia with 0.5 lt/min fresh gas flow. In both groups dynamic compliance values, peak inspiratory pressure (PIP) values, total inhalation anesthetic drug consumption, total remifentanil drug consumption, duration of anesthesia, and duration of surgery were recorded. The FVC, FEV1, and FEV1/FVC values of the patients in both groups were evaluated and noted 24 hours before the operation, after the operation 2nd, 8th, and 24th hours.


Eligibility criteria: Inclusion Criteria:

* ASA I-II
* 18-65 years of age, who will undergo elective laparoscopic cholecystectomy surgery

Exclusion Criteria:

* ASA III-IV
* Smokers
* Body mass index (BMI) \> 40 kg / m2,
* Patients with cardiovascular system disease
* Chronic respiratory diseases,
* Patients whose pulmonary function tests cannot be applied and who have problems with pulmonary function tests during the examination of the chest disease consultant

Primary outcomes:
measure: Dynamic Compliance assessment
timeFrame: 5th minutes after endotracheal intubation
measure: Dynamic Compliance assessment
timeFrame: 5th minutes after surgical incision
measure: Dynamic Compliance assessment
timeFrame: 10th minutes after surgical incision
measure: Dynamic Compliance assessment
timeFrame: 30th minutes after surgical incision
measure: Dynamic Compliance assessment
timeFrame: 60th minutes after surgical incision
measure: Dynamic Compliance assessment
timeFrame: immediately after the end of the surgical suturing
measure: Peak inspiratory pressure assessment
timeFrame: 5th minutes after endotracheal intubation
measure: Peak inspiratory pressure assessment
timeFrame: 5th minutes after the surgical incision
measure: Peak inspiratory pressure assessment
timeFrame: 10th minutes after the surgical incision
measure: Peak inspiratory pressure assessment
timeFrame: 30th minutes after the surgical incision
measure: Peak inspiratory pressure assessment
timeFrame: 60th minutes after the surgical incision
measure: Peak inspiratory pressure assessment
timeFrame: immediately after the end of the surgical suturing
Secondary outcomes:
measure: FEV1 measures assessment
timeFrame: 24 hours before the operation
measure: FEV1 measures assessment
timeFrame: 2nd hour after the operation
measure: FEV1 measures assessmentt
timeFrame: 8th hour after the operation
measure: FEV1 measures assessment
timeFrame: 24th hour after the operation
measure: FVC measures assessment
timeFrame: 24 hours before the operation
measure: FVC measures assessment
timeFrame: 2nd hour after the operation
measure: FVC measures assessment
timeFrame: 8th hour after the operation
measure: FVC measures assessment
timeFrame: 24th hour after the operation
measure: FEV1/FVC measures assessment
timeFrame: 24 hours before the operation
measure: FEV1/FVC measures assessment
timeFrame: 2nd hour after the operation
measure: FEV1/FVC measures assessment
timeFrame: 8th hour after the operation
measure: FEV1/FVC measures assessment
timeFrame: 24th hour after the operation
Other outcomes:
Locations:
city: Erzurum
country: Turkey
facility: Erkan Cem ÇELİK
Study officials:
References: