louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01506622: Comparison Between Propofol and Fentanyl for Prevention of Emergence Agitation in Children After Sevoflurane Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Emergence Agitation
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2012-01-10
Enrollment: 222
Sex: ALL
Minimum age (years): 18
Maximum age (years): 72
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: The occurrence of emergence agitation (EA) in pediatric patients who have received sevoflurane anesthesia is a common postoperative problem. The prevalence of EA varies between 10% to 80% depending on the scoring system for evaluation and the anesthetic technique used.

Many authors reported various strategies such as use of sedative premedication, change of maintenance technique of anesthesia, or pharmacological agents administered at the end of anesthesia to reduce the incidence and severity of EA, and to allow a smooth emergence from sevoflurane anesthesia. Among these strategies, the use of pharmacological agents at the end of anesthesia is not affected by anesthetic duration, and may not prolong recovery duration of anesthesia excessively when these agents are administered as subhypnotic or small dose. The typical agents that can be administered in this way are propofol and fentanyl.

Previous studies demonstrated that the use of either propofol or fentanyl at the end of anesthesia could reduce the incidence of EA.

The purpose of this study is to compare the preventive effect on EA and the characteristics of anesthesia recovery between propofol and fentanyl administered at the end of sevoflurane anesthesia.


Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists I or II,
* 18-72 months of age,
* scheduled for ambulatory inguinal hernia repair undergoing general sevoflurane anesthesia

Exclusion Criteria:

* developmental delay
* psychological and neurologic disorder
* sedatives medication
* an abnormal airway
* reactive airway disease
* extreme agitation and uncooperation
* previous history of anesthesia

Primary outcomes:
measure: The incidence of emergence agitation
timeFrame: Participants will be followed for the duration of postanesthesia care unit (PACU) stay, an expected average of one hour.
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Yonsei University
Study officials:
References:
citation: Chen J, Li W, Hu X, Wang D. Emergence agitation after cataract surgery in children: a comparison of midazolam, propofol and ketamine. Paediatr Anaesth. 2010 Sep;20(9):873-9. doi: 10.1111/j.1460-9592.2010.03375.x.
Clinical trial NCT05575622: Clinical Study for Combined Analysis of CTC and Exosomes on Predicting the Efficacy of Immunotherapy in Patients With Hepatocellular Carcinoma
Official title: Clinical Study for Combined Analysis of CTC and Exosomes on Predicting the Efficacy of Immunotherapy in Patients With Hepatocellular Carcinoma
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Lead sponsor: Zhongnan Hospital
Sponsor class: OTHER
First posted: 2022-10-12
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients in this study were enrolled by the Clinical Trial Centerin Zhongnan Hospital.

Brief summary: This project intends to perform CTC PD-L1 imaging, exosomal PD-L1 protein detection, and exosomal LAG-3 protein detection, so as to resolve the functional marker profiles of immunotherapy in the peripheral blood of HCC patients and comprehensively present the responsiveness of patients to immunotherapy.

Detailed description: Liquid biopsy methods such as PD-L1 of CTC, number of peripheral immune cells and their subtypes, and exosomal PD-L1 provide a dynamic monitoring strategy for immunotherapy evaluation. Monitoring CTC and immune-related functional markers in peripheral blood can dynamically reflect the multi-dimensional characteristics of tumor microenvironment, comprehensively represent the response of patients to immunotherapy, and provide a new strategy of companion diagnostics for immunotherapy in HCC. This project intends to perform CTC PD-L1 imaging, exosomal PD-L1 protein detection, and exosomal LAG-3 protein detection, so as to resolve the functional marker profiles of immunotherapy in the peripheral blood of HCC patients and comprehensively present the responsiveness of patients to immunotherapy.

Eligibility criteria: Inclusion Criteria:

* having signed informed consent
* clinically or pathologically confirmed hepatocellular carcinoma;
* liver tumor load not exceeding 50% of liver volume;
* expected survival ≥ 12 weeks;
* vital organ function meeting enrollment criteria; and (6) no need for pregnancy.

Exclusion Criteria:

* Patients who have been diagnosed with malignant tumors of other systems or organs;
* Patients with hematologic disorders and extreme physical failure;
* Patients with immune deficiencies or organ transplants;
* Other conditions deemed by the investigator to be inappropriate for participation in this study.

Primary outcomes:
measure: CTC-PD-L1, exosomal PD-L1, and exosomal LAG-3
timeFrame: Treatment baseline; Up to 2 months from the initial treatment; From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Zhongnan Hospital of Wuhan University
state: Hubei
Study officials:
affiliation: Wuhan University
name: Fubing Wang, Doctor
role: STUDY_DIRECTOR
References:
Clinical trial NCT04081922: Postoperative Analgesia With Erector Spinae Plane Block After Pectus Excavatum Repair in Children
Official title: Postoperative Analgesia With Erector Spinae Plane Block After Pectus Excavatum Repair in Children
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pectus Excavatum
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2019-09-09
Enrollment: 30
Sex: ALL
Minimum age (years): 3
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy of erector spinae plane (ESP) block in children after pectus excavatum repair (nuss procedure).


Eligibility criteria: Inclusion Criteria:

* 30 children aged between 3 and 7 years who undergo Nuss bar insertion due to Pectus excavatum

Exclusion Criteria:

* Allergy to opioid
* Allergy to local anesthetics
* Disease in heart, lung, kidney, and liver
* Coagulation disorder
* Disease in central and peripheral nervous system

Primary outcomes:
measure: Pain score
timeFrame: 1 hour after surgery
Secondary outcomes:
measure: Fentanyl dosage (mcg/kg)
timeFrame: until hospital discharge (postoperative day 3)
measure: Dose of rescue analgesics (mg/kg)
timeFrame: until hospital discharge (postoperative day 3
measure: Plasma concentration of ropivacaine
timeFrame: 5, 10, 20, 30, 60, 120 minutes after injection
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul national university hospital
Study officials:
affiliation: Seoul National University Hospital
name: Jin-Tae Kim, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04595422: Educating Smokers About Lung Cancer Screening Using Tobacco Quitlines
Official title: Educating Smokers About Lung Cancer Screening Using Tobacco Quitlines
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Lung Carcinoma
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2020-10-20
Enrollment: 800
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This implementation study will examine the best ways to refer heavy smokers to information about lung cancer screening.

Detailed description: PRIMARY OBJECTIVE:

I. To increase the number of smokers eligible for lung cancer screening (LCS) who receive high-quality educational materials about LCS through tobacco quitlines.

OUTLINE:

CALL CENTER STAFF: Participants undergo training consisting of a 60-minute educational session.

CALLERS SUBSTUDY: Participants are referred to lung cancer screening educational materials. Participants also complete questionnaires at 1 week and 6 months after referral to educational materials.

Eligibility criteria: Inclusion Criteria:

* QUITLINE CALL CENTER STAFF
* Staff member of a quitline
* Aged 18 years and above
* CALLERS (SMOKERS WHO CONTACT THE QUITLINE ABOUT SMOKING CESSATION SERVICES) INCLUSION CRITERIA
* Callers 55-80 years of age
* Current smoker, or former smoker with a cessation history of \< 15 years
* \>= 30 pack-year smoking history
* English-speaking

Exclusion Criteria:

* CALLERS (SMOKERS WHO CONTACT THE QUITLINE ABOUT SMOKING CESSATION SERVICES) EXCLUSION CRITERIA
* History of lung cancer by self-report

Primary outcomes:
measure: Content from communications (email, phone, monthly calls)
timeFrame: Up to 4 years
measure: Healthcare sector perspective
timeFrame: Up to 4 years
measure: Reach
timeFrame: During 6 month implementation period
measure: Overall lung cancer screening rate
timeFrame: Up to 6 months
measure: Effectiveness (Caller Substudy)
timeFrame: Up to 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: M D Anderson Cancer Center
state: Texas
Study officials:
affiliation: M.D. Anderson Cancer Center
name: Robert J Volk
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00357422: Comparison Study of Operation and PEIT for Small, Solitary Hepatocellular Carcinoma (HCC)
Official title: Prospective Randomized Trial of the Effective Therapy for Small, Solitary HCC Comparing Operation and Percutaneous Ethanol Injection Therapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hepatocellular Carcinoma
Keywords: HCC, operation, percutaneous ethanol injection
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2006-07-27
Enrollment: 36
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to choose the preferred treatment modality for solitary, small hepatocellular carcinoma.

Detailed description: To compare the below things between operation group and percutaneous ethanol injection therapy (PEIT) group:

1. Survival

   * 5 year overall survival rate
   * Disease free survival rate
2. Recurrence

   * Cumulative recurrence rate

Eligibility criteria: Inclusion Criteria:

* The evidences of hepatitis B virus (HBV)\&/or hepatitis C virus (HCV) infection or liver cirrhosis
* Single tumor nodule with Child-Pugh classification A (serum albumin ≥ 3.2 g/dL)
* The maximal, longest diameter of tumor mass measured by CT finding should be less than 2 cm
* Only for the newly detected HCCs which were not treated before
* It should be compatible with the typical finding of hepatocellular carcinomas (HCCs) radiologically (MD CT or dynamic MRI)
* Without portal hypertension

Exclusion Criteria:

* In case of hepatic vein or portal vein invasion radiologically (CT or MRI)

Primary outcomes:
measure: overall survival rate
timeFrame: 5 year
Secondary outcomes:
measure: disease free survival rate and recurrence rate
timeFrame: 5 year
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul NUH
state: Chongno-gu
Study officials:
affiliation: Seoul National University Hospital
name: J H Yoon, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01024322: Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas
Official title: Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Keratoconus
Ectasia
Degeneration
Keywords: Diagnosis of keratoconus, post-LASIK ectasia, FFKC, or pellucid marginal degeneration
Lead sponsor: Cxlusa
Sponsor class: INDUSTRY
First posted: 2009-12-02
Enrollment: 1189
Sex: ALL
Minimum age (years): 8
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Primary care clinic.

Brief summary: To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or between collagen fibers using UVA light and the photo- mediator riboflavin. The purpose of this study is to generate data for presentation at medical meetings and for peer-review publication


Eligibility criteria: Inclusion Criteria:

* 8 years of age or older
* Diagnosis of keratoconus, post-LASIK ectasia, or pellucid marginal degeneration or forme fruste pellucid marginal degeneration.
* Diagnosis of FFKC
* History of Radial Keratotomy with fluctuating vision.
* Terrien's Marginal Degeneration
* Ability to provide written informed consent
* Likely to complete all study visits
* Minimum corneal thickness of at least 300 250 microns measured by ultrasound or Pentacam for all indications other than Terriens. For Terriens, the minimal corneal thickness should be consistent with the surgeon's best surgical judgment.

Exclusion Criteria:

* Severe corneal scarring that markedly affects vision
* Contraindications to any study medications or their components
* Pregnancy or breast feeding
* Active Herpes Corneal Disease

Primary outcomes:
measure: Increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within
timeFrame: 1 year
Secondary outcomes:
measure: increase the biomechanical and biochemical stability of the cornea between collagen fibers using UVA light and the photo- mediator riboflavin
timeFrame: 1 year
Other outcomes:
Locations:
city: Miami
country: United States
facility: The Center for Excellence in Eye Care
state: Florida
city: Rockville
country: United States
facility: TLC Laser Eye Center
state: Maryland
city: Fairfax
country: United States
facility: TLC Laser Eye Center
state: Virginia
Study officials:
affiliation: The Center for Excellence in Eye Care
name: William Trattler, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Re: Vision
name: Roy Rubinfeld, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00812422: The Efficacy and Safety of Dexibuprofen Syrup
Official title: Multi-center, Randomized, Double Blinded (Double-dummy), Active-Controlled Parallel-group Comparative, Phase 3 Clinical Trial to Assess the Efficacy and Safety of Dexibuprofen Syrup Compared to Ibuprofen Syrup in Patients With Fever of Common Cold (Acute Upper Respiratory Infection)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Fever
Respiratory Tract Infection
Keywords: Fever due to acute upper respiratory tract infection
Lead sponsor: Inje University
Sponsor class: OTHER
First posted: 2008-12-22
Enrollment: 260
Sex: ALL
Minimum age (years): 6
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the safety and efficacy of dexibuprofen syrup and ibuprofen syrup in patients with fever due to common cold.


Eligibility criteria: Inclusion Criteria:

* Common cold with fever
* Age 6 months to 14 years

Exclusion Criteria:

* Gastric ulcer
* Bleeding tendency
* Liver disease
* Kidney disease
* Hypertension
* Hypersensitivity to the drug

Primary outcomes:
measure: measure reduction in fever
timeFrame: measure temperature every hour for 3 hours then once again 3 days later
Secondary outcomes:
measure: determine safety of dexibuprofen by unwanted reaction, clinical laboratory test and physical examination.
timeFrame: every hour for 3 hours (unwanted reaction). 3 days later (clinical laboratory test and physical examination).
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Inje University Sanggye Paik Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Hospital
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Young Yull Koh
role: STUDY_DIRECTOR
affiliation: Inje University
name: Chang-Keun Kim
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06323122: A Comparative Study Between Three Different Plating Techniques in Management of Mandibular Parasymphyseal Fractures.
Official title: A Comparative Study Between Three Different Plating Techniques in Management of Mandibular Parasymphyseal Fractures. A Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mandibular Fractures
Keywords: parasymphyseal
mandibular fracture
internal fixation
miniplates
3D miniplate
Lead sponsor: October 6 University
Sponsor class: OTHER
First posted: 2024-03-21
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients who had suffered from a recent mandibular fractures in the symphyseal or parasymphyseal region which required Open Reduction with Internal Fixation (ORIF)

Brief summary: The main goal in management of mandibular fractures is to restore the pre-injury form and function, with the least disability and shortest recovery period.

Detailed description: Currently there are a diversity of metallic hardware used for fixation of jaw fractures. However, the proper selection of the suitable technique is still a matter of debate.

The aim of the current study was to compare between the effect of two miniplates, 2.3 high profile Miniplates and three dimensional (3D) Miniplates for internal fixation treatment of mandibular para-symphyseal fractures.

Eligibility criteria: Inclusion Criteria:

1. Patients with symphyseal/ parasymphyseal mandibular fracture.
2. Patients presenting within 7 days of trauma.

Exclusion Criteria:

1. Associated fractures that could affect occlusion or dimensions
2. Medically compromised patients who are unfit for management under General Anesthesia
3. Patients with gross infection at the site of fracture
4. Patients not willing to return for follow-up
5. Patients with associated bone pathology

Primary outcomes:
measure: Surgery Time
timeFrame: intraoperative
Secondary outcomes:
measure: complication
timeFrame: 6 months
measure: fracture stability
timeFrame: 6 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: October 6U
Study officials:
affiliation: Associated Professor of oral and maxillofacial surgery, Oral Surgery Department
name: Nermine Ramadan Mahmoud, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hu W, Agrawal M, Thadani S, Mukul SK, Sood R, Patel A, Dhanak R, Tailor S. Comparative evaluation of a single 2.0-mm AO locking reconstruction plate with conventional miniplate osteosynthesis for treatment of linear non-comminuted fractures of symphysis and parasymphsis region of the mandible. J Stomatol Oral Maxillofac Surg. 2019 Feb;120(1):11-15. doi: 10.1016/j.jormas.2018.10.002. Epub 2018 Oct 26.
Clinical trial NCT00562822: Surgery Versus No Surgery for Osteoarthritis (OA) of the Knee
Official title: Arthroscopic vs. Non-surgical Treatment of Osteoarthritis of the Knee
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Osteoarthritis of the Knee
Lead sponsor: University of Western Ontario, Canada
Sponsor class: OTHER
Collaborators: name: Canadian Institutes of Health Research (CIHR)
First posted: 2007-11-22
Enrollment: 188
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to discover whether arthroscopic surgery is helpful in controlling the symptoms of osteoarthritis of the knee.

Detailed description: Although arthroscopic surgery has been widely used for osteoarthritis of the knee, scientific evidence to support its efficacy is lacking. This study will compare optimized physical and medical therapy alone with arthroscopic treatment in addition to optimized physical and medical therapy.

Eligibility criteria: Inclusion Criteria:

* Idiopathic or secondary osteoarthritis of the knee with Grade II to IV radiographic severity as defined by the modified Kellgren and Lawrence classification

Exclusion Criteria:

* Patients with inflammatory or post-infectious arthritis
* Those who had undergone previous arthroscopic treatment for knee osteoarthritis
* Those with isolate Grade III to IV medical compartment osteoarthritis with greater than 5 degrees of varus deformity.

Primary outcomes:
measure: Function, pain and quality of life based on the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) scores
timeFrame: 2 years
Secondary outcomes:
measure: Health utility using the Standard Gamble Technique
timeFrame: 24 months
Other outcomes:
Locations:
city: London
country: Canada
facility: London Health Sciences Centre - University Hospital
state: Ontario
Study officials:
affiliation: Western University, Canada
name: Peter J Fowler, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Western University, Canada
name: Brian G Feagan, MD
role: STUDY_CHAIR
References:
citation: Moseley JB, O'Malley K, Petersen NJ, Menke TJ, Brody BA, Kuykendall DH, Hollingsworth JC, Ashton CM, Wray NP. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2002 Jul 11;347(2):81-8. doi: 10.1056/NEJMoa013259.