Clinical trial NCT02900339: Magnetic Resonance Imaging (MRI) Sequences Optimization in Healthy Subjects
Official title: MRI Sequences Optimization in Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Volunteers
Keywords: MRI
Sequence optimization
Healthy volunteers
Lead sponsor: Rennes University Hospital
Sponsor class: OTHER
First posted: 2016-09-14
Enrollment: 628
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Magnetic resonance imaging (MRI) is a noninvasive and non-ionizing (no use of X-rays) imaging modality. Today it is considered an anatomical and functional exploration reference technique. Since its inception around 1985, this technology is constantly evolving.

Many advances in MRI require constant adaptations of radiological practices. The morphological image is now associated with functional and parametric information (infusion, diffusion spectroscopy, etc ...). In parallel, work combining acquisition and post-processing of data also open new applications (tractography, functional MRI, etc ....). Thus, more and more procedures are necessary to "integrate" these techniques for the diagnosis and adapt to new demands of clinicians.

The type of sequence and its associated parameters allow to directly influence the contrast of images, to characterize tissue compared to another and, ultimately, to highlight morphological or functional abnormality. Image quality can be optimized on each MRI, depending on the time available for the acquisition on the one hand, and on the desired resolution and contrast, on the other hand. For each sequence, it is therefore necessary to find a compromise that will optimize the diagnostic quality of the examination.

This optimization requires a phase focusing on healthy volunteers. It is therefore important that researchers and physicists could design on healthy volunteers, the best settings of all parameters for an image or spectrum. Indeed, it is always necessary to properly optimize every parameter choices before beginning a study of a cohort of patients.

In this context, the main objective of this study is to optimize sequences and imaging protocols to evaluate and validate the choice of parameters in healthy volunteers.


Eligibility criteria: Inclusion Criteria:

* Men or women aged over 18 years
* Written informed consent given

Exclusion Criteria:

* contraindication to MRI :

  * Claustrophobia
  * morphotype not allowing access to MRI
  * Wear a metallic implant, such as:
  * Pacemaker (pacemaker)
  * Ferromagnetic surgical clips
  * Intra orbital metallic foreign bodies or encephalic
* Pregnancy
* Breastfeeding
* Adults under guardianship, trusteeship or safeguard justice
* No social Insurance

Primary outcomes:
measure: Quantitative assessment of acquired sequences
timeFrame: One day after data acquisitions
Secondary outcomes:
measure: Qualitative assessment of acquired sequences
timeFrame: One day after data acquisitions
Other outcomes:
Locations:
city: Rennes cedex 9
country: France
facility: Radiology Department CHU de Rennes
Study officials:
affiliation: CHU Rennes
name: Jean-Christophe FERRE, MD, PhD
role: STUDY_DIRECTOR
References: