Clinical trial NCT04303351: Periodontitis and Atherosclerotic-related Arterial Stenosis
Official title: The Relationship Between Periodontitis and Atherosclerotic-related Arterial Stenosis in the Chinese Population
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Atherosclerosis of Artery
Keywords: arterial stenosis
periodontitis
atherosclerosis
risk factors
Lead sponsor: Guangzhou University of Traditional Chinese Medicine
Sponsor class: OTHER
First posted: 2020-03-11
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 98
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study population are people who underwent cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine from April 2020 to April 2022 and meat the inclusion and exclusion criteria

Brief summary: This study aimed to evaluate the association between periodontitis and atherosclerosis of the cerebral vasculature in the Chinese population.

Detailed description: Periodontitis has been demonstrated as a risk factor for ischaemic stroke in several clinical studies. Atherosclerosis of the cerebral vasculatureis an important pathological process causing ischaemic stroke. The investigator's study aims to investigate the relationship between tooth loss(used as a surrogate of periodontal disease) and atherosclerotic-related arterial stenosis in the Chinese population. An estimated 1,000 participants that underwent cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine between Apirl 2020 and January 2022 will be recruited in this trial. Arterial stenosis features of each participants will be collected based on the results of digital subtraction angiography (DSA). The missing teeth counts of each participant will be collected and some of them will recieved comprehensive periodontal examination. Besides, blood samples will be collected in order to investigate the serum inflammatory markers(CRP,WBC,albumin,IL-6,IL-10). The relationship between tooth loss and atherosclerotic-related arterial stenosis will be analysed by regression models adjusted for conventional risk factors (sex,age, obesity,smoking,Alcohol drinking,diabetes,hypertension,hyperuricaemia,hyperhomocysteinaemia)

Eligibility criteria: Inclusion Criteria:

1. subjects who underwent cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine from April 2020 to December 2021
2. subjects who voluntarily participated in this study and provided informed consent.

Exclusion Criteria:

1. intracranial and extracranial artery stenosis caused by vascular inflammation, systemic connective tissue disease, and muscle fibre structure hypoplasia
2. inability to cooperate with the investigation
3. intracranial aneurysm and cerebral arteriovenous malformation confirmed by cerebral angiography
4. receipt of periodontal treatment in the previous 24 months.

Primary outcomes:
measure: The relationship between atherosclerotic-related stenosis in different brain arteries and tooth loss categories
timeFrame: 1 day
Secondary outcomes:
measure: The relationship between the severity of artery stenosis and tooth loss categories
timeFrame: 1 day
Other outcomes:
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