Clinical trial NCT04109339: Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy
Official title: Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Oxytocin
Hemodynamic Monitoring
Laparoscopic Surgery
Keywords: Oxytocin
Hemodynamic
Myomectomy
Lead sponsor: Yangzhou University
Sponsor class: OTHER
First posted: 2019-09-30
Enrollment: 80
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This project will study the effect of oxytocin on hemodynamics in patients undergoing laparoscopic myomectomy, and how to prevent and manage such hemodynamic changes effectively.It provides a reference for the rational use of oxytocin in clinical practice, which can not only effectively contract the uterus and reduce bleeding, but also reduce the influence on hemodynamics.


Eligibility criteria: Inclusion Criteria:

* General anesthesia for gynecological laparoscopic surgery,ASA I\~III

Exclusion Criteria:

* Oxytocin use contraindications

Primary outcomes:
measure: Changes of traditional hemodynamic parameters after oxytocin use during laparoscopic hysteromyomectomia.
timeFrame: "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection".
measure: Changes of traditional hemodynamic parameters after oxytocin use during laparoscopic hysteromyomectomia.
timeFrame: "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection".
measure: Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia.
timeFrame: "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection".
measure: Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia.
timeFrame: "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection".
measure: Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia.
timeFrame: "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection".
measure: Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia.
timeFrame: "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection".
Secondary outcomes:
Other outcomes:
Locations:
city: Yangzhou
country: China
facility: the Affiliated Hospital of Yangzhou University
state: Jiangsu
Study officials:
References: