Clinical trial NCT01562769: Interest of Contact Precautions for Preventing Micro-organisms Acquisition in Patients Hospitalized in Infectious Disease Unit of University-affiliated Hospital in Rennes
Official title: Interest of Contact Precautions for Preventing Micro-organisms Acquisition in Patients Hospitalized in Infectious Disease Unit of University-affiliated Hospital in Rennes
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Patients Hospitalized in Infectious Disease
Lead sponsor: Rennes University Hospital
Sponsor class: OTHER
First posted: 2012-03-26
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients hospitalized in Infectious Disease Unit of university-affiliated hospital in Rennes

Brief summary: Application of isolation (=contact precautions) in hospitalized patients is recommended when patient is colonized (or infected) by micro-organism known for its outbreak capacity or high pathogenicity. It allows the reinforcement of universal precautions (=standard precautions) in order to control patient-to-patient micro-organisms transmission. Recently, the efficacy of this measure is questioned and its impact on patient care seems deleterious.

In a particular context of Infectious Disease Unit, where standard precautions are handled (favorable architecture and appropriate practice for hand hygiene), assessment of contact precautions to reduce the incidence of acquired bacteria during hospitalization would be of interest.

The investigators design a non-inferiority comparative study to measure the colonization pressure in patients hospitalized in two different parts of the department: one unit only with standard precautions applied (intervention) and one unit with contact precautions (control) as current routine care.


Eligibility criteria: Inclusion Criteria:

* Patient hospitalized in Infectious Diseases Unit during the study period in one of the selected part of the unit participating to the study
* Patient informed about the study protocol and approved to participate.

Exclusion Criteria:

* Patient requiring isolation prescription type "air" or "droplet"
* Patient hospitalized in the central sector of the building (including 4 bedrooms in depression negative service)
* Patient colonized with bacteria producing carbapenemase, multi-resistant Acinetobacter baumanii or Vancomycin-Resistant Enterococcus.
* Patients under legal protection (juridical protection, legal guardianship) or persons on juridical detention.

Primary outcomes:
measure: Acquisition rate of micro-organisms
timeFrame: 2 years
Secondary outcomes:
measure: Number of infections acquired during hospitalization in each group
timeFrame: 2 years
measure: Consumption of hydro-alcoholic rub in each group
timeFrame: 2 years
measure: Utilization of aprons and gloves in each group
timeFrame: 2 years
Other outcomes:
Locations:
city: Rennes
country: France
facility: Rennes University Hospital
state: Brittany
Study officials:
affiliation: Rennes University Hospital
name: jean-marc chapplain
role: PRINCIPAL_INVESTIGATOR
References: