Clinical trial NCT02555774: Efficacy of Cognitive Training in Subjective Memory Impairment
Official title: A Prospective, Three-arm, Parallel Design, Controlled Trial to Assess Efficacy of Cognitive Training in Subjective Memory Impairment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Memory Loss
Keywords: subjective memory impairment
cognitive training
Lead sponsor: Asan Medical Center
Sponsor class: OTHER
First posted: 2015-09-22
Enrollment: 65
Sex: ALL
Minimum age (years): 55
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluates the efficacy of cognitive training in subjects with subjective memory impairment. The first group will receive cognitive training and lifestyle modification in combination, the second group will receive only lifestyle modification, and the third group will receive no intervention.

Detailed description: Subjective memory impairment is currently thought to be a risky state of progression to Alzheimer's disease. This study aims to confirm whether cognitive training in subjective memory impairment would show improvement in the subjective and objective cognition. We include subjects with normal cognition but complained subjective feeling of memory decline and conduct cognitive training programs combined with lifestyle modifications for 3 months. We evaluate the neuropsychological tests and questionnaires about subjective improvement after 3 months of interventions.

Eligibility criteria: Inclusion Criteria:

* Subjects who showed normal range (above 16percentile of norm) in all domains of detailed neuropsychological tests battery named Seoul Neuropsychological Screening Battery (SNSB)
* Clinical dementia rating (CDR) score of 0
* Subjects with at least 3 years of formal education

Exclusion Criteria:

* Subjects with mild cognitive impairment or dementia
* Subjects who was diagnosed as any neurological disorders such as epilepsy, stroke, hemorrhage, hydrocephalus, Parkinson's disease or brain tumor
* Subjects with uncontrolled severe medical conditions according to investigator's opinion

Primary outcomes:
measure: Paired associates learning test
timeFrame: 3 month
measure: Rapid visual information processing test
timeFrame: 3 month
measure: Pattern recognition memory test
timeFrame: 3 month
measure: Spatial working memory test
timeFrame: 3 month
Secondary outcomes:
measure: cognitive failure questionnaire
timeFrame: 3 month
measure: Mini-mental state examination
timeFrame: 3 month
measure: Geriatric depression scale
timeFrame: 3 month
measure: Beck anxiety index
timeFrame: 3 month
measure: Seoul instrumental activities of daily living
timeFrame: 3 month
measure: Rey complex figure copy test
timeFrame: 3 month
measure: Digit symbol test
timeFrame: 3 month
measure: Seoul verbal learning test, immediate recall
timeFrame: 3 month
measure: Seoul verbal learning test, delayed recall
timeFrame: 3 month
measure: Seoul verbal learning test, delayed recall
timeFrame: 3 month
measure: Logical memory test, delayed recall
timeFrame: 3 month
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Jae-Hong Lee
Study officials:
affiliation: Asan Medical Center
name: Jae-Hong Lee, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References: