louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03854422: For Easy, Fast and Comfortable Colonoscopy, Which Position
Official title: Which Position is Suitable for Easy, Fast and Comfortable Colonoscopy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Colonic Diseases, Functional
Prone Position
Endoscopy
Keywords: Colonoscopy
Insertıon tecnique
Prone
Left Supine
Dynamic
Lead sponsor: Bulent Ecevit University
Sponsor class: OTHER
First posted: 2019-02-26
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: this study includes 3 different groups. left, left supine,dynamıc
Primary purpose: SCREENING

Brief summary: Colonoscopy is one of the most common endoscopic procedures today. However, it sometimes can be a serious challenging situation both for the clinicians and patients. In this study, the investigators tried to determine which colonoscopic position allows easy, fast and comfortable way.

Detailed description: colonoscopy and colonoscopic screening are the most common routine studies to reduce the incidence of colorectal cancer.In this process, the most important problem for the endoscopist and the patient is pain, loop formation, (the reason why the device is not able to progress in the bowel) and in some patients it takes a long time due to these reasons and the risk of complication development.The subject of what should be the most ideal position in colonoscopy has previously been studied in some specific subgroups.There is not enough study on what should be the ideal position in colonoscopy. In this study, the investigators tried to determine which colonoscopic position allows easy, fast and comfortable way.

Eligibility criteria: Inclusion Criteria:

* Adult patients aged for 18 to 80 years,
* colonoscopy indications (iron deficiency anemia ,Malignancy screening in patients over 50 years of age,secret blood positivity in stool, rectal bleeding,patients describing Hematoconia, chronic diarrhea, constıpatıon

Exclusion Criteria:

* patients with previous colon surgery
* serious comorbid disease (congestive heart failure ef\< %30 , advanced chronic obstructive pulmonary disease,terminal period cancer with a life expectancy of less than 5 years, those who have not had appropriate bowel cleaning,endoscopic treatment during colonoscopy or removal of diagnostic lesions,other sedatives for sedation other than midazolam

Primary outcomes:
measure: Time to reach cecum
timeFrame: 2 hour
Secondary outcomes:
measure: patient's comfort assessment: Visual Analog Score
timeFrame: 3 hour
Other outcomes:
Locations:
city: Zonguldak
country: Turkey
facility: Betul Topal
state: Kozlu Bulent Ecevit University Faculty OF Medicine
Study officials:
affiliation: BULENT ECEVIT UNIVERSITY FACULTY OF MEDICINE , GASTROENTEROLOGY
name: TARIK AKAR, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT04352322: Effectiveness of Oral Hyaluronic Acid in Knee Osteoarthritis
Official title: Effectiveness of Oral Hyaluronic Acid (A+ HA(tm), TOP Pharm.) in Knee Osteoarthritis: Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Osteoarthritis
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
Collaborators: name: TOP Pharm & Medicalware
First posted: 2020-04-20
Enrollment: 47
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study was a randomized, double-blind, placebo-controlled study evaluating the efficacy of an oral liquid HA supplement (A+HA) in symptoms relief and improvement of quality of life in knee osteoarthritis patients with mild knee pain.

Detailed description: Subjects were initially screened at the Randomization/Baseline Visit (Week 0). Eligible subjects were randomized at the same visit into the treatment period and received the assigned treatment in a double-blind fashion for 8 weeks. During the 8 weeks treatment period, there were three follow-up visits requested (Week 2, Week 4 and Week 8). Efficacy was measured by using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Short Form-36 (SF-36).

Eligibility criteria: Inclusion Criteria:

* Male or female age \>= 40 years old
* Diagnosed with knee OA which met the definition of Ahlbӓck classification12 and had knee joint symptoms within 30 days prior to enrollment

Exclusion Criteria:

* Had administered glucosamine one month prior to enrollment
* Had known allergy to oral HA
* BMI ≧40 kg/m2
* Knee OA was caused by occupational hazard or sports injury
* Patients with known other causes of arthritis (infectious rheumatoid or psoriatic arthritis), bony or soft tissue malignancy or peripheral neuropathy involving the lower extremities, cardiopulmonary disease which limited walking more than knee pain, knee instability defined as a report of knee buckling or locking within the past month of the study knee, major neurological deficit that affected gait, psychiatric illness that limited informed consent or Parkinsonism
* Women in pregnancy
* Wheel chair users

Primary outcomes:
measure: WOMAC
timeFrame: 8 weeks
Secondary outcomes:
measure: SF-36
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: TOP Pharm. & Medicalware
Study officials:
affiliation: China Medical University Hospital
name: Shyu-Jye Wang, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wang SJ, Wang YH, Huang LC. The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial. Medicine (Baltimore). 2021 Feb 5;100(5):e24252. doi: 10.1097/MD.0000000000024252.
Clinical trial NCT00573222: Non-interventional Surveillance of Effectiveness of Symbicort® Maintenance And Reliever Therapy (Symbicort® SMART) in the Treatment of Moderate and Severe Asthma
Official title: Non-interventional Surveillance of Effectiveness of Symbicort® Maintenance And Reliever Therapy (Symbicort® SMART) in the Treatment of Moderate and Severe Asthma
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Asthma
Keywords: Asthma
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2007-12-14
Enrollment: 330
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: pulmonology clinics

Brief summary: This is a 3-month non-interventional, observational study on patients with moderate and severe asthma.


Eligibility criteria: Inclusion Criteria:

* Patients with moderate and severe asthma on Symbicort SMART treatment

Exclusion Criteria:

* Under 18 years old

Primary outcomes:
measure: To evaluate & describe asthma control in adult patients w/moderate to severe asthma treated w/Symbicort SMART following the frequency, type & severity of symptoms through the Asthma Control Questionnaire.
Secondary outcomes:
measure: to evaluate the safety of Symbicort SMART treatment through the number and type of reported adverse events 2. assessment of patient's satisfaction with the treatment 3.assessment of physician's satisfaction with the treatment
Other outcomes:
Locations:
city: Cakovec
country: Croatia
facility: Research Site
city: Dubrovnik
country: Croatia
facility: Research Site
city: Osijek
country: Croatia
facility: Research Site
city: Pozega
country: Croatia
facility: Research Site
city: Pula
country: Croatia
facility: Research Site
city: Rijeka
country: Croatia
facility: Research Site
city: Senj
country: Croatia
facility: Research Site
city: Sibenik
country: Croatia
facility: Research Site
city: Slavonskibrod
country: Croatia
facility: Research Site
city: Vinkovci
country: Croatia
facility: Research Site
city: Vukovar
country: Croatia
facility: Research Site
city: Zadar
country: Croatia
facility: Croatia
city: Zagreb
country: Croatia
facility: Research Site
Study officials:
affiliation: AstraZeneca
name: Anan Marija Gjurovic
role: STUDY_DIRECTOR
References:
Clinical trial NCT04577222: The Ability of Adipose Flap Over the NVB to Improve Sexual and Urinary Function Following Radical Prostatectomy
Official title: The Ability of Adipose Flap Over the NVB to Improve Sexual and Urinary Function Following Radical Prostatectomy; a Randomized Control Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Prostate Cancer
Erectile Dysfunction
Urinary Incontinence
Lead sponsor: Rabin Medical Center
Sponsor class: OTHER
First posted: 2020-10-06
Enrollment: 60
Sex: MALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Despite technological advances, incontinence and impotence remain significant side effects of radical prostatectomy (RP). Strategies have been developed to reduce the injury to the erection nerves (i.e. neurovascular bundle - NVB)during surgery to further improve functional outcomes after RP. Adipose tissue is known for its stabilizing and even healing potential. These features include reducing the inflammatory process and improving blood supply to an injured nerve. We hypothesized that covering the NVB with periprostatic fat during surgery may potentially improve neural recovery and enhance functional recovery after RP. We sought to examine our hypothesis in a randomized controlled trial.


Eligibility criteria: Inclusion Criteria:

1. Male aged 18 years and older.
2. Patients diagnosed with prostate cancer.
3. Patients should be potent (IIEF erectile function domain score of 26 and above) and have a sexual partner.
4. Patients scheduled for Radical Prostatectomy with NVB preservation (at least unilateral).

Exclusion Criteria:

Patients who did not undergo NVB preservation or technical inability to create flap

Primary outcomes:
measure: Erectile function
timeFrame: Change from Baseline IIEF score at 12 months
Secondary outcomes:
measure: Continence status
timeFrame: Change from Baseline King's score at 12 months
Other outcomes:
Locations:
city: Petach Tikva
country: Israel
facility: Rabin Medical Center
Study officials:
References:
Clinical trial NCT01686022: Grass Sensitisation and Allergic Rhinitis in Thai Patients
Official title: The Study of Allergens From Grass and Weed Which Are Causes of Allergic Rhinitis in Thai Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Allergy to Grass Pollen
Allergic Rhinitis Due to Weed Pollens
Keywords: Grass
Major allergen
cross-reactivity
Lead sponsor: Mahidol University
Sponsor class: OTHER
Collaborators: name: National Research Council of Thailand
First posted: 2012-09-17
Enrollment: 40
Sex: ALL
Minimum age (years): 10
Maximum age (years): 50
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Allergy Clinic

Brief summary: Allergic rhinitis patients are the patients who have nasal symptoms when triggered by indoor or outdoor allergens. Outdoor allergen can be divided into grass, tree, or weed. The type of grass or weed are different in various part of the world. The allergens from grass and weed has never been studied in Thailand. This study will find the major allergen from Bermuda grass, Johnson grass, Para grass, sedge, and ragweed, which are very common in Thailand. In addition, the investigators will study about the cross-reactivity among these group of allergen.

Detailed description: To find the major allergen of grass and weed, the serum of patients will be used to bind with the allergen extract by immunoblot study.

The ELISA-inhibition will be used to study about cross-reactivity among various kinds of grass and weed.

Eligibility criteria: Inclusion Criteria:

* Allergic rhinitis patients age 10-50 years old
* Control: healthy volunteer age 18-50 years old

Exclusion Criteria:

* Chronic illness such as cardiovascular diseases, liver diseases
* History of anaphylaxis
* Pregnancy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Bangkoknoi
country: Thailand
facility: Siriraj Hospital
state: Bangkok
Study officials:
affiliation: Mahidol University
name: Punchama Pacharn, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03846622: Comparison of Scoring Systems for Bleeding in Open Cardiac Surgery Patients
Official title: Comparison of Preoperative Scoring Systems for Prediction of Perioperative Bleeding in Patients To Be Operated for Open Cardiac Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bleeding
Lead sponsor: Kocaeli Derince Education and Research Hospital
Sponsor class: OTHER
First posted: 2019-02-19
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients over 18 years of age who were operated for elective open cardiac surgery.

Brief summary: Seven different scoring systems used for prediction of perioperative bleeding were compared regarding patients operated for elective open cardiac surgery in the investigator's study.

Detailed description: Collected data of 500 consecutive patients, operated for elective open cardiac surgery were analyzed retrospectively. Seven different scoring systems were used to predict the probability of bleeding, including TRACK, PAPWORTH, WILL-BLEED, CRUSADE, ACTION, TRUST and ACTA-PORT. The scores are calculated for each of these systems by using their own parameters, and classified into four risk groups as very low, low, moderate and high. Then, these risk groups were compared with patients identified in two groups regarding the use of perioeprative erythrocyte suspension (ES) transfusions or not, as ES positive and ES negative.

Eligibility criteria: Inclusion Criteria:

1. Patients with 18 years of age or older,
2. Patients operated for elective open cardiac surgery.

Exclusion Criteria:

1. Patients with incomplete data,
2. Patients with an age less than 18 years,
3. Patients operated for emergent surgical procedures.

Primary outcomes:
measure: Bleeding scores
timeFrame: Bleeding risk scores were calculated through study completion, an average of 2 years.
measure: The amount of blood transfusions
timeFrame: The amount of blood transfusions were recorded through study completion, an average of 2 years.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Associate professor of the department of anaesthesiology and reanimation
name: Tolga Saracoglu
role: STUDY_DIRECTOR
References:
Clinical trial NCT04318522: Non-Invasive Brain Stimulation
Official title: Effect of Conventional Transcranial Direct Current Stimulation (c-tDCS) and High-definition Transcranial Direct Current Stimulation (HD-tDCS) on the Prefrontal Cortex
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Stroke
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2020-03-24
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The study focusses on utilizing neuroimaging modalities, including Electroencephalography (EEG) and Functional Magnetic Resonance Imaging (fMRI) to study the impact of non-invasive brain stimulation on the prefrontal cortex during a cognitive task.

Detailed description: In this study, a total of 40 subjects will be randomly assigned to 2 groups i.e. experimental and sham. Conventional transcranial direct current stimulation (c-tDCS) and high-definition transcranial direct current stimulation (HD-tDCS) will be used to stimulate the prefrontal cortex of the brain. EEG and fMRI will be collected before, during and after stimulation to understand the impact of stimulation on brain dynamics. The investigators hypothesize that the stimulation of the prefrontal cortex will improve performance during cognitive tasks along with changes in the neural processing detected by neuroimaging modalities.

Eligibility criteria: Inclusion Criteria:

* Right Handedness,
* Age \> 18

Exclusion Criteria:

* History of any other neurological disease,
* Any psychological or psychiatric disease,
* Significant visual or auditory impairments,
* tDCS contraindications including implanted metallic or electronic devices, seizures or convulsions, and pregnancy.

Primary outcomes:
measure: Reaction Time (RT)
timeFrame: 1 hour
measure: Concentration Rate
timeFrame: 1 hour
measure: Event related potential latency and amplitude
timeFrame: 1 hour
measure: Functional Magnetic Resonance Imaging (fMRI)
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Shatin
country: Hong Kong
facility: Department of Biomedical Engineering, The Chinese University of Hong Kong
Study officials:
affiliation: Department of Biomedical Engineering, CUHK
name: Raymond Tong, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Khan A, Chen C, Eden CH, Yuan K, Tse CY, Lou W, Tong KY. Impact of anodal high-definition transcranial direct current stimulation of medial prefrontal cortex on stroop task performance and its electrophysiological correlates. A pilot study. Neurosci Res. 2022 Aug;181:46-54. doi: 10.1016/j.neures.2022.03.006. Epub 2022 Apr 1.
citation: Khan A, Wang X, Ti CHE, Tse CY, Tong KY. Anodal Transcranial Direct Current Stimulation of Anterior Cingulate Cortex Modulates Subcortical Brain Regions Resulting in Cognitive Enhancement. Front Hum Neurosci. 2020 Dec 16;14:584136. doi: 10.3389/fnhum.2020.584136. eCollection 2020.
Clinical trial NCT02480322: Metabolomic Fingerprint After Bariatric Surgery
Official title: Metabolomic Fingerprint of Severe Obesity is Dynamically Affected by Bariatric Surgery in a Procedure-dependent Manner
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Keywords: metabolic alterations
Lead sponsor: eSwiss Medical & Surgical Center
Sponsor class: OTHER
Collaborators: name: University of Florence
name: FiorGen Foundation, Italy
First posted: 2015-06-24
Enrollment: 106
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: severely obese patients of the Interdisciplinary Obesity Center, St. Gallen, Switzerland

Brief summary: Background: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that cannot only reduce body weight but also obesity-associated morbidity.

Objective: The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood.

Design: In the longitudinal observational study, the investigator applied a 1H-NMR-based global, untargeted metabolomics strategy on human serum samples that were collected before and repeatedly up to one year after distinct bariatric procedures (sleeve gastrectomy, proximal and distal Roux-en Y gastric bypass; RYGB). For comparison, the investigator also analyzed serum samples from normal-weight and less obesity obese subjects that were matched for 1-year postoperative BMI values of the surgical groups.


Eligibility criteria: Inclusion Criteria:

* BMI \>/=35 kg/m2
* at least 2 years of unsuccessful conservative weight loss attempts

Exclusion Criteria:

* \< 18 years of age
* BMI \< 35 kg/m2
* informed consent was not signed by the patient

Primary outcomes:
measure: compare the NMR metabolic fingerprint as assessed in serum samples of severely obese patients with that of normal-weight control subjects
timeFrame: pre operative
measure: follow up changes in the metabolic fingerprint over one year after 3 distinct bariatric procedures
timeFrame: pre operative, 3-, 6-, 9- and 12 months post operative
measure: compare the metabolic fingerprints established one year after the different surgeries with those of BMI-matched and normal-weight control subjects
timeFrame: 12 months post operative
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Gralka E, Luchinat C, Tenori L, Ernst B, Thurnheer M, Schultes B. Metabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner. Am J Clin Nutr. 2015 Dec;102(6):1313-22. doi: 10.3945/ajcn.115.110536. Epub 2015 Nov 18.
Clinical trial NCT06288022: Comparison of Total Tubeless Mini-PCNL Versus Tubeless Mini-PCNL
Official title: Comparison of Total Tubeless Mini-PCNL Versus Tubeless Mini-PCNL : A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Surgery-Complications
Nephrolithiasis Staghorn Calculus
Safety Issues
Keywords: total tubeless PCNL
complication
safety
tubeless PCNL
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2024-03-01
Enrollment: 130
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized Controlled Trial in 2 group

1. total tubeless mini-PCNL
2. tubeless mini-PCNL
Primary purpose: OTHER

Brief summary: Limited literature has focused on the use of totally tubeless mini-percutaneous nephrolithotomy (Mini-PCNL) for the treatment of large renal stones.

This Randomized Controlled trial aims to compare complication and safety of Mini-PCNL between total tubeless and tubeless Mini-PCNL.

Detailed description: After being informed about study and potential risks, all patient giving written informed consent with undergo a mini-PCNL operation. Patient who meet the eligibility requirements will be randomized in a single-blind manner (patient) in a 1:1 ratio to total tubeless mini-PCNL or tubeless mini-PCNL.

Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with kidney stones with a size ranging from 20 to 40 millimeters.
* Patients have undergone mini-PCNL, unilateral
* Absence of urinary tract infections before surgery.
* No urological congenital abnormality
* No coagulopathy

Exclusion Criteria:

* Presence of residual stones after the surgery, fragments larger than 4 millimeters.
* Patients with a single functioning kidney
* Complicated cases, including:

  1. massive bleeding in the upper tract during surgery
  2. Severe collecting systems injury during surgery
  3. Severe UPJ mucosa swelling considered unsafe by the physician, requiring the placement of a DJ stent or nephostomy tube
* Participants who decline or request withdrawal from the research study.

Primary outcomes:
measure: incidence of complications between total tubeless mini-pcnl and tubeless mini-PCNL
timeFrame: from post operative day 0 to day 45
Secondary outcomes:
measure: The secondary objective is to assess the surgical outcomes between total tubeless mini-pcnl and tubeless mini-PCNL
timeFrame: from post operative day 0 to day 45
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Ramathibodi Hospital, Mahidol University
state: Ratchathewi
Study officials:
affiliation: Ramathibodi Hospital, Mahidol University
name: THANAKORN SIRAJARUS
role: PRINCIPAL_INVESTIGATOR
References: