Clinical trial NCT06832436: Atrial Strain in Septic Shock
Official title: Assessment of Left and Right Atrial Strain in Septic Shock
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Septic Shock
Left Atrial Strain
Right Atrial Strain
Transthoracic Echocardiography
Speckle Tracking
Echocardiographic Software
Reproducibility
Critical Care
Keywords: transthoracic echocardiography
septic shock
left atrial strain
right atrial strain
speckle tracking
echocardiographic software
AutoStrain
Bland-Altman analysis
reproducibility
critical care
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
Collaborators: name: Henri Mondor University Hospital
First posted: 2025-02-18
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)

Brief summary: Septic shock is a critical condition associated with high mortality. Transthoracic echocardiography is widely used to evaluate cardiac function and guide treatment. Left and right atrial strain (LAS and RAS) measured via speckle tracking echocardiography have shown prognostic value in cardiovascular diseases. However, differences exist between echocardiographic software, leading to challenges in result comparability. This study aims to compare LAS and RAS measurements between ECHOPAC and UWS software, evaluate AutoStrain technology, and assess reproducibility across observers. The study is non-interventional and will use retrospective echocardiographic data from patients treated for septic shock. The findings will contribute to improving measurement standardization in critically ill patients.


Eligibility criteria: Inclusion Criteria:

* Age: \>18 years
* Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)
* TTE performed as part of medical management
* No objection to data usage

Exclusion Criteria:

* Pregnancy
* Moderate to severe valvular regurgitation/stenosis (\>grade 2)
* Ventricular or supraventricular tachyarrhythmia (HR \>140 bpm) at the time of TTE
* Poor echogenicity preventing LAS measurement
* Mechanical circulatory support
* Pacemaker dependence
* Patients under guardianship

Primary outcomes:
measure: variation of LASr between ECOPAC and UWS
timeFrame: 1 year
Secondary outcomes:
measure: variation of LAScd between ECHOPAC and UWS
timeFrame: 1 year
measure: variation of LASct between ECHOPAC and UWS
timeFrame: 1 year
measure: Comparison of LASr measurements in apical 2-chamber views
timeFrame: 1 year
measure: Comparison of LAScd measurements in apical 2-chamber views
timeFrame: 1 year
measure: Comparison of LASct measurements in apical 2-chamber views
timeFrame: 1 year
measure: Comparison of right atrial strain RASr between ECHOPAC and UWS
timeFrame: 1 year
measure: Comparison of right atrial strain RAScd between ECHOPAC and UWS
timeFrame: 1 year
measure: Comparison of right atrial strain RASct between ECHOPAC and UWS
timeFrame: 1 year
measure: Comparison of LAS in AutoStrain versus manual mode
timeFrame: 1 year
measure: Comparison of RAS in AutoStrain versus manual mode
timeFrame: 1 year
measure: Comparison of LAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC
timeFrame: 1 year
measure: Comparison of RAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC
timeFrame: 1 year
measure: Assessment of differences in LAS measurements at end-diastole between ECHOPAC and UWS
timeFrame: 1 year
measure: Assessment of differences in LAS measurements at pre-A between ECHOPAC and UWS
timeFrame: 1 year
measure: Assessment of differences in RAS measurements at end-diastole between ECHOPAC and UWS
timeFrame: 1 year
measure: Assessment of differences in RAS measurements at pre-A between between ECHOPAC and UWS
timeFrame: 1 year
measure: Inter-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients
timeFrame: 1 year
measure: Intra-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients
timeFrame: 1 year
measure: Inter-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients
timeFrame: 1 year
measure: Intra-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients
timeFrame: 1 year
Other outcomes:
Locations:
city: Salouel
country: France
facility: CHRU Amiens
Study officials:
References: