Clinical trial NCT05891951: Effect of Carotid Ultrasound-guided Fluid Management on Anesthetic-induced Hypotension in Elderly Patients Undergoing Gastrointestinal Surgery
Official title: Effect of Carotid Ultrasound-guided Fluid Management on Anesthetic-induced Hypotension in Elderly Patients Undergoing Gastrointestinal Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hypotension on Induction
Lead sponsor: First Affiliated Hospital of Chongqing Medical University
Sponsor class: OTHER
First posted: 2023-06-07
Enrollment: 150
Sex: ALL
Minimum age (years): 60
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This is a randomized controlled clinical study to investigate whether carotid ultrasound-guided fluid therapy reduces the incidence of induced hypotension in elderly patients undergoing gastrointestinal surgery.
Primary purpose: PREVENTION

Brief summary: The goal of this clinical trial is to learn about Whether carotid ultrasound guided fluid management can reduce the incidence of hypotension after general anesthesia induction in elderly patients undergoing gastrointestinal surgery.

The main question\[s\] it aims to answer are:

Whether fluid therapy reduces the incidence of general anaesthesia induced hypotension in elderly patients undergoing gastrointestinal surgery.

Whether carotid ultrasound can guide fluid management in elderly patients undergoing gastrointestinal surgery.

Participants will use carotid ultrasound to assess volume status. If volume is insufficient, fluid therapy will be selected until volume is sufficient, anesthesia will be then induced. If volume is sufficient, anesthesia will be directly induced. There is a comparison group: No carotid ultrasound will be used to assess the volume status of the patients, and anesthesia will be directly induced.


Eligibility criteria: Inclusion Criteria:

* Age 60-80 years old
* gender unlimited
* ASA: Grade I-Ⅲ
* BMI:18-30kg/㎡
* Patients undergoing elective gastrointestinal surgery under general anesthesia Informed consent

Exclusion Criteria:

* Carotid artery stenosis ≥50%
* Patients with heart valve disease
* Patients with left ventricular ejection fraction \< 50%
* Patients with cardiac dysfunction (NYHA grade Ⅲ-Ⅳ and/or NTproBNP≥900pg/ml)
* Patients Combined with renal insufficiency (creatinine ≥178μmol/L, and/or blood urea nitrogen \> 9mmol/L)
* Preoperative systolic blood pressure\> 160mmHg or diastolic blood pressure \> 100mmHg
* Refuse to participate in the test
* Patients participating in other clinical trials

Primary outcomes:
measure: Occurrence of hypotension after anesthesia induction
timeFrame: General anesthesia induction from the beginning to 20 minutes after induction
Secondary outcomes:
measure: Postoperative acute kidney injury
timeFrame: Within 7 days after surgery
measure: postoperative delirium
timeFrame: Within 30 days after surgery
measure: postoperative stroke
timeFrame: Within 30 days after surgery
Other outcomes:
Locations:
city: Chongqing
country: China
facility: China,Chongqing The First Affiliated Hospital of Chongqing Medical University
state: Chongqing
Study officials:
affiliation: First Affiliated Hospital of Chongqing Medical University
name: Su Min
role: STUDY_DIRECTOR
References: