Clinical trial NCT04141722: Age-Related Changes in Sleep-Dependent Emotional Memory
Official title: AGE-RELATED CHANGES IN SLEEP-DEPENDENT EMOTIONAL MEMORY
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Sleep
Age
Emotional Valence
Keywords: Emotional Memory
Memory Consolidation
Age-Related Positivity Effect
Lead sponsor: University of Massachusetts, Amherst
Sponsor class: OTHER
First posted: 2019-10-28
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression. Conversely, reactivating positive memories has been shown to reduce stress and symptoms of depression. In young adults, sleep is widely implicated in emotional processing, including consolidation of emotional memories. Evidence suggests that aging is associated with changes in emotion, including a positive memory bias and enhanced emotional well-being. These changes have been termed the "age-related positivity effect." However, the influence of sleep on these measures has not been investigated in healthy older individuals. The objective of this research is to understand the role of sleep in emotional memory consolidation and emotional well-being across adulthood. We hypothesize that sleep contributes to the age-related positivity effect in memory and affect. Our alternative hypothesis is that age-related decreases in sleep are responsible for reduced emotional memory processing over healthy aging.


Eligibility criteria: Inclusion Criteria:

* 18-30 or 50-80 years of age
* Have no history of a sleep disorder
* Have no history of neurological disease or injury
* Have no history of psychiatric illness (anxiety or mood disorder, schizophrenia, etc.)
* No history of chemotherapy
* Not be taking medications which effect sleep
* Habitually sleep more than 6 or more hours per night
* Be able to walk freely and independently
* Have normal to corrected-to-normal vision

Primary outcomes:
measure: Memory bias
timeFrame: 12 hr delay between encoding and recognition test
Secondary outcomes:
Other outcomes:
Locations:
city: Amherst
country: United States
facility: University of Massachusetts, Amherst
state: Massachusetts
Study officials:
affiliation: University of Massachusetts, Amherst
name: Rebecca Spencer
role: PRINCIPAL_INVESTIGATOR
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