Clinical trial NCT06012435: A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer
Official title: A Randomized, Phase 3, Open-label Study to Evaluate Sigvotatug Vedotin Compared With Docetaxel in Adult Participants With Previously Treated Non-small Cell Lung Cancer (Be6A Lung-01)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Carcinoma, Non-Small-Cell Lung
Keywords: Non-Small Lung Cancer
Seattle Genetics
lung cancer
advanced lung cancer
metastatic lung cancer
non small cell lung cancer
stage 3 lung cancer
stage 4 lung cancer
lung cancer treatment
lung cancer clinical trial
nonsquamous lung cancer
ADC
Pfizer cancer trial
vedotin
lung disease
phase 3 lung
Lead sponsor: Seagen Inc.
Sponsor class: INDUSTRY
First posted: 2023-08-25
Enrollment: 670
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This clinical trial is studying nonsquamous non-small cell lung cancer (NSCLC). Participants in this study must have cancer that has spread through their body or can't be removed with surgery. Participants in this study must have been treated with no more than a platinum-based chemotherapy and an anti-PD-(L)1 drug. Participants with tumors that have certain treatable genomic alterations must have had at least 1 drug for that genomic alteration, in addition to platinum-based chemotherapy.

This clinical trial uses an experimental drug called sigvotatug vedotin, which is a type of antibody drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. This clinical trial also uses a drug called docetaxel. Docetaxel is an anticancer drug that has been approved to treat non-small cell lung cancer. It is usually given to patients who previously received another anticancer treatment. In this study, one group of participants will get sigvotatug vedotin on Days 1 and 15 during each 28-day-cycle. A second group of participants will get docetaxel on Day 1 during each 21-day cycle.

This study is being done to see if sigvotatug vedotin works better than docetaxel to treat participants with NSCLC. This study will also test what side effects happen when participants take these drugs. A side effect is anything a drug does to the body besides treating the disease.


Eligibility criteria: Inclusion Criteria:

* Histologically or cytologically confirmed diagnosis of locally advanced, unresectable (Stage IIIB, IIIC), or metastatic Stage IV (M1a, M1b, or M1c) NSCLC American Joint Committee on Cancer (AJCC) Staging Manual, Version 8.0, and the Union for International Cancer Control (UICC) Staging System (Eighth edition).
* Participants must have NSCLC with nonsquamous histology

  * Tumors with squamous, or predominantly squamous histology are excluded.
  * Tumors with small cell elements are excluded.
* Participants who have NSCLC with known actionable genomic alteration (AGAs) are permitted
* Participants must have received the following prior therapies and progressed during or relapsed after receiving their most recent prior therapy:

  * Participants with no known AGAs must fulfill 1 of the following conditions:

    * Received a platinum-based combination therapy for the treatment of metastatic or recurrent disease and a PD-(L)1 monoclonal antibody (concurrently or sequentially with platinum-based chemotherapy), unless contraindicated.
    * Experienced disease progression within 6 months of the last dose of platinum-based chemotherapy in the adjuvant or neoadjuvant setting and received a PD-(L)1 monoclonal antibody at any time during the course of treatment.
  * Participants with known AGAs must fulfill the following conditions:

    * Must have received at least 1 relevant AGA targeted therapy and in the opinion of the investigator, additional AGA targeted therapy is not in the best interest of the participant.
    * Received a platinum-based combination therapy for the treatment of metastatic or recurrent disease, or experienced disease progression within 6 months of the last dose of platinum-based chemotherapy in the adjuvant or neoadjuvant setting
    * May have received up to 1 PD-(L)1 monoclonal antibody (concurrently or sequentially with platinum-based chemotherapy).
* Measurable disease based on RECIST v1.1
* Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, with adequate baseline hematologic, hepatic, and renal function and measurable disease according to RECIST v1.1

Exclusion Criteria:

* Life expectancy of less than (\<) 3 months
* Known allergies/hypersensitivity/intolerance to or contraindication of taxanes, docetaxel, or any excipient contained in the drug formulation of sigvotatug vedotin
* History of another malignancy within 3 years before Cycle 1 Day 1, or any evidence of residual disease from a previously diagnosed malignancy. Exceptions are malignancies with a negligible risk of metastasis or death
* Participants with any of the following respiratory conditions:

  * Evidence of noninfectious interstitial lung disease (ILD) or pneumonitis that:

    * Was previous diagnosed and required systemic steroids, or
    * Is currently diagnosed and managed, or
    * Is suspected on radiologic imaging at screening
  * Known diffusing capacity of the lung for carbon monoxide (DLCO) \< 50%
  * Any Grade greater than or equal to (≥) 3 pulmonary disease unrelated to underlying malignancy
* Pre-existing peripheral neuropathy Grade greater than or equal to (≥) 2
* Uncontrolled diabetes mellitus
* Prior therapy:

  * Prior treatment with antimicrotubule agents (taxanes, vinca alkaloids, or MMAEs) in the locally advanced, unresectable/refractory, or metastatic setting
  * Prior antimicrotubule agent exposure in curative settings (including adjuvant, neoadjuvant, or chemoradiotherapy) is permissible.
  * Received more than 1 prior line of cytotoxic chemotherapy in the locally advanced, unresectable/refractory, or metastatic setting
  * Prior cytotoxic chemotherapy in curative settings is permissible
  * At least 14 days must have elapsed from the last dose of radiotherapy until Cycle 1 Day 1.
  * Prior radiation therapy to the lung parenchyma that is \>30 Gray (Gy) within 6 months of Cycle 1 Day 1.
  * Any systemic anticancer therapy (standard or experimental) within 21 days prior to Cycle 1 Day 1.
* Active central nervous system (CNS) lesions, including leptomeningeal metastasis, are excluded. Participants with definitively treated brain metastases are eligible in they meet the following criteria:

  * Have been clinically stable for at least 4 weeks prior to treatment initiation and baseline scans show no evidence of new or enlarged metastasis
  * On a stable dose of less than or equal to (≤) 10mg/day of prednisone or equivalent for a least 2 weeks (if requiring steroid treatment)
  * Treatment with corticosteroids greater than (\>) 1 month prior to Screening visit
  * No evidence of clinical and radiographic disease progression in the CNS for ≥ 21 days after definitive radiotherapy and/or surgery

Primary outcomes:
measure: Overall survival (OS) between the experimental arm (sigvotatug vedotin) and control arm (docetaxel) in all participants and in participants whose tumors express high levels of integrin beta-6 (IB6-high)
timeFrame: Approximately 5 years
measure: Progression Free Survival (PFS) per Response Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST v1.1) by Blinded Independent Central Review (BICR) between the experimental and control arms in all participants and in the IB6-high subgroup
timeFrame: Approximately 5 years
Secondary outcomes:
measure: Confirmed Objective Response Rate (ORR) per RECIST v1.1 as assessed by BICR between the experimental and control arms in all participants and in the IB6-high subgroup
timeFrame: Approximately 5 years
measure: Confirmed ORR per RECIST v1.1 by investigator assessment
timeFrame: Approximately 5 years
measure: PFS per RECIST v1.1 by investigator assessment
timeFrame: Approximately 5 years
measure: Duration of Response (DOR) per RECIST v1.1 by BICR
timeFrame: Approximately 5 years
measure: DOR per RECIST v1.1 by investigator assessment
timeFrame: Approximately 5 years
measure: Number of participants with adverse events (AEs)
timeFrame: Through 30 days after the last study intervention; Approximately 5 years
measure: Mean score in the global health status/QoL combined score on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)
timeFrame: Approximately 5 years
measure: Change from baseline in global health status/QoL combined score on the EORTC QLQ-C30
timeFrame: Approximately 5 years
measure: Mean score in physical functioning scores on the EORTC QLQ-C30
timeFrame: Approximately 5 years
measure: Change from baseline score in physical functioning scores on the EORTC QLQ-C30
timeFrame: Approximately 5 years
measure: Mean score in role functioning scores on the EORTC QLQ-C30
timeFrame: Approximately 5 years
measure: Change from baseline score in role functioning scores on the EORTC QLQ-C30
timeFrame: Approximately 5 years
measure: Mean scores in the dyspnea, cough, and chest pain scores on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer 13 (EORTC QLQ-LC13)
timeFrame: Approximately 5 years
measure: Change from baseline in the dyspnea, cough, and chest pain scores on the EORTC QLQ-LC13
timeFrame: Approximately 5 years
measure: Time to Deterioration (TTD) in the global health status/QoL combined score on the EORTC QLQ-C30
timeFrame: Approximately 5 years
measure: TTD in physical functioning scores on the EORTC QLQ-C30
timeFrame: Approximately 5 years
measure: TTD in role functioning scores on the EORTC QLQ-C30
timeFrame: Approximately 5 years
measure: TTD in the dyspnea, cough, and chest pain scores on the EORTC QLQ-LC13
timeFrame: Approximately 5 years
Other outcomes:
Locations:
city: Alabaster
country: United States
facility: Alabama Oncology
state: Alabama
city: Bessemer
country: United States
facility: Alabama Oncology
state: Alabama
city: Birmingham
country: United States
facility: Alabama Oncology
state: Alabama
city: Birmingham
country: United States
facility: Alabama Oncology
state: Alabama
city: Birmingham
country: United States
facility: Alabama Oncology
state: Alabama
city: Birmingham
country: United States
facility: Alabama Oncology
state: Alabama
city: Anchorage
country: United States
facility: Alaska Oncology and Hematology, LLC
state: Alaska
city: Goodyear
country: United States
facility: Arizona Oncology Associates
state: Arizona
city: Prescott
country: United States
facility: Arizona Oncology Associates
state: Arizona
city: Bakersfield
country: United States
facility: Comprehensive Blood and Cancer Center TRIO
state: California
city: Fullerton
country: United States
facility: Providence Medical Foundation
state: California
city: Fullerton
country: United States
facility: Providence St. Jude Medical Center
state: California
city: Los Alamitos
country: United States
facility: Cancer and Blood Specialty Clinic
state: California
city: Los Alamitos
country: United States
facility: Cancer Blood and Specialty Clinic
state: California
city: Los Angeles
country: United States
facility: Regulatory Management Only: TRIO-US Central Administration
state: California
city: Los Angeles
country: United States
facility: Drug Management Only: UCLA West Medical Pharmacy, Attn: Steven L Wong, Pharm.D.
state: California
city: Orange
country: United States
facility: Cancer and Blood Care Specialists
state: California
city: Orange
country: United States
facility: Cancer& Blood Specialty Clinic
state: California
city: Orange
country: United States
facility: Providence Medical Foundation
state: California
city: Orange
country: United States
facility: St. Joseph Hospital Orange
state: California
city: San Francisco
country: United States
facility: UCSF Medical Center - Mission Bay
state: California
city: Santa Barbara
country: United States
facility: Sansum Clinic
state: California
city: Solvang
country: United States
facility: Sansum Clinic
state: California
city: Aurora
country: United States
facility: Rocky Mountain Cancer Centers LLP
state: Colorado
city: Boulder
country: United States
facility: Rocky Mountain Cancer Centers LLP
state: Colorado
city: Colorado Springs
country: United States
facility: Rocky Mountain Cancer Centers LLP
state: Colorado
city: Denver
country: United States
facility: Rocky Mountain Cancer Centers LLP
state: Colorado
city: Denver
country: United States
facility: Rocky Mountain Cancer Centers LLP
state: Colorado
city: Lakewood
country: United States
facility: Rocky Mountain Cancer Centers LLP
state: Colorado
city: Littleton
country: United States
facility: Rocky Mountain Cancer Centers LLP
state: Colorado
city: Lone Tree
country: United States
facility: Rocky Mountain Cancer Centers LLP
state: Colorado
city: Longmont
country: United States
facility: Rocky Mountain Cancer Centers LLP
state: Colorado
city: Pueblo
country: United States
facility: Rocky Mountain Cancer Centers LLP
state: Colorado
city: Derby
country: United States
facility: Smilow Cancer Hospital - Derby
state: Connecticut
city: Fairfield
country: United States
facility: Smilow Cancer Hospital - Fairfield
state: Connecticut
city: Glastonbury
country: United States
facility: Smilow Cancer Hospital - Glastonbury
state: Connecticut
city: Greenwich
country: United States
facility: Smilow Cancer Hospital - Greenwich
state: Connecticut
city: Guilford
country: United States
facility: Smilow Cancer Hospital - Guilford
state: Connecticut
city: Hartford
country: United States
facility: Smilow Cancer Hospital at St. Francis
state: Connecticut
city: New Haven
country: United States
facility: Smilow Cancer Hospital - Yale New Haven Health
state: Connecticut
city: New Haven
country: United States
facility: Yale - New Haven Hospital - Yale Cancer Center
state: Connecticut
city: North Haven
country: United States
facility: Smilow Cancer Hospital - North Haven
state: Connecticut
city: Torrington
country: United States
facility: Smilow Cancer Hospital - Torrington
state: Connecticut
city: Trumbull
country: United States
facility: Smilow Cancer Hospital - Trumbull
state: Connecticut
city: Waterbury
country: United States
facility: Smilow Cancer Hospital - Waterbury
state: Connecticut
city: Waterford
country: United States
facility: Smilow Cancer Hospital - Waterford
state: Connecticut
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Melbourne
country: United States
facility: Cancer Care Centers of Brevard, Inc.
state: Florida
city: Miami
country: United States
facility: Miami Cancer Institute at Baptist Health, Inc.
state: Florida
city: Palm Bay
country: United States
facility: Cancer Care Centers of Brevard, Inc.
state: Florida
city: Rockledge
country: United States
facility: Cancer Care Centers of Brevard, Inc.
state: Florida
city: Arlington Heights
country: United States
facility: Illinois Cancer Specialists
state: Illinois
city: Niles
country: United States
facility: Illinois Cancer Specialists
state: Illinois
city: Annapolis
country: United States
facility: Maryland Oncology Hematology P.A.
state: Maryland
city: Bethesda
country: United States
facility: Maryland Oncology Hematology P.A.
state: Maryland
city: Brandywine
country: United States
facility: Maryland Oncology Hematology P.A.
state: Maryland
city: Columbia
country: United States
facility: Maryland Oncology Hematology P.A.
state: Maryland
city: Germantown
country: United States
facility: Maryland Oncology Hematology P.A.
state: Maryland
city: Largo
country: United States
facility: Maryland Oncology Hematology P.A.
state: Maryland
city: Rockville
country: United States
facility: Maryland Oncology Hematology P.A.
state: Maryland
city: Silver Spring
country: United States
facility: Maryland Oncology Hematology P.A.
state: Maryland
city: Boston
country: United States
facility: Boston Medical Center
state: Massachusetts
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center
state: Massachusetts
city: Fairhaven
country: United States
facility: Southcoast Centers for Cancer Care
state: Massachusetts
city: Fall River
country: United States
facility: Southcoast Centers for Cancer Care
state: Massachusetts
city: Burnsville
country: United States
facility: Minnesota Oncology Hematology, P.A
state: Minnesota
city: Chaska
country: United States
facility: Minnesota Oncology Hematology, P.A
state: Minnesota
city: Coon Rapids
country: United States
facility: Allina Health Cancer Institute - Mercy Hospital
state: Minnesota
city: Coon Rapids
country: United States
facility: Minnesota Oncology Hematology, P.A
state: Minnesota
city: Edina
country: United States
facility: M Health Fairview Cancer Clinic-Edina
state: Minnesota
city: Maple Grove
country: United States
facility: Minnesota Oncology Hematology, P.A
state: Minnesota
city: Maplewood
country: United States
facility: M Health Fairview St. John's Hospital
state: Minnesota
city: Minneapolis
country: United States
facility: Minnesota Oncology Hematology, P.A
state: Minnesota
city: Minneapolis
country: United States
facility: Allina Health Cancer Institute - Abbott Northwestern Hospital
state: Minnesota
city: Minneapolis
country: United States
facility: Hennepin County Medical Center
state: Minnesota
city: Plymouth
country: United States
facility: Minnesota Oncology Hematology, P.A
state: Minnesota
city: Robbinsdale
country: United States
facility: North Memorial Health Cancer Center
state: Minnesota
city: Saint Louis Park
country: United States
facility: Park Nicollet Frauenshuh Cancer Center
state: Minnesota
city: Saint Paul
country: United States
facility: Regions Hospital
state: Minnesota
city: Saint Paul
country: United States
facility: Allina Health Cancer Institute - United Hospital
state: Minnesota
city: Woodbury
country: United States
facility: Minnesota Oncology Hematology, P.A
state: Minnesota
city: Hattiesburg
country: United States
facility: Hattiesburg Clinic Hematology/Oncology.
state: Mississippi
city: Kansas City
country: United States
facility: Saint Luke's Cancer Institute LLC
state: Missouri
city: Omaha
country: United States
facility: University of Nebraska Medical Center.
state: Nebraska
city: Omaha
country: United States
facility: University of Nebraska Medical Center
state: Nebraska
city: Henderson
country: United States
facility: Comprehensive Cancer Centers of Nevada
state: Nevada
city: Henderson
country: United States
facility: Comprehensive Cancer Centers of Nevada
state: Nevada
city: Las Vegas
country: United States
facility: Comprehensive Cancer Centers of Nevada
state: Nevada
city: Las Vegas
country: United States
facility: Comprehensive Cancer Centers of Nevada
state: Nevada
city: Las Vegas
country: United States
facility: Comprehensive Cancer Centers of Nevada
state: Nevada
city: Las Vegas
country: United States
facility: Comprehensive Cancer Centers of Nevada
state: Nevada
city: Berkeley Heights
country: United States
facility: Summit Medical Group
state: New Jersey
city: Clifton
country: United States
facility: Summit Medical Group
state: New Jersey
city: Florham Park
country: United States
facility: Summit Medical Group
state: New Jersey
city: Albuquerque
country: United States
facility: New Mexico Cancer Center
state: New Mexico
city: Albuquerque
country: United States
facility: University of New Mexico Comprehensive Cancer Center
state: New Mexico
city: Mineola
country: United States
facility: NYU Langone Hospital
state: New York
city: Mineola
country: United States
facility: Perlmutter Cancer Center at NYU Langone Hospital - Long Island
state: New York
city: New York
country: United States
facility: Laura & Isaac Perlmutter Cancer Center - NYU ACC
state: New York
city: New York
country: United States
facility: Laura& Isaac Perlmutter Cancer Center at NYU Langone Health
state: New York
city: New York
country: United States
facility: NYU Langone Medical Center
state: New York
city: Avon
country: United States
facility: University Hospitals Seidman Cancer Center at UH Avon Health Center
state: Ohio
city: Cincinnati
country: United States
facility: Oncology Hematology Care Clinical Trials, LLC
state: Ohio
city: Cincinnati
country: United States
facility: Oncology Hematology Care Clinical Trials, LLC
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Taussig Cancer Center Investigational Pharmacy
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals Cleveland Medical Center
state: Ohio
city: Cleveland
country: United States
facility: Fairview Hospital Moll Pavilion - Cleveland Clinic Cancer Center
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
city: Fairfield
country: United States
facility: Oncology Hematology Care Clinical Trials, LLC
state: Ohio
city: Maumee
country: United States
facility: Taylor Cancer Research Center
state: Ohio
city: Mayfield Heights
country: United States
facility: Hillcrest Hospital - Cleveland Clinic Cancer Center
state: Ohio
city: Mentor
country: United States
facility: University Hospitals Seidman Cancer Center at UH Mentor Health Center
state: Ohio
city: Orange Village
country: United States
facility: UH Minoff Health Center at Chagrin Highlands
state: Ohio
city: Beaverton
country: United States
facility: Oregon Health and Science University - CHO Beaverton
state: Oregon
city: Eugene
country: United States
facility: Oncology Associates of Oregon, P.C.
state: Oregon
city: Gresham
country: United States
facility: Oregon Health and Science University - CHO Gresham
state: Oregon
city: Portland
country: United States
facility: Oregon Health and Science University - CHO Northwest
state: Oregon
city: Portland
country: United States
facility: Oregon Health and Science University - CHO East Portland
state: Oregon
city: Portland
country: United States
facility: Northwest Cancer Specialists, P.C.
state: Oregon
city: Portland
country: United States
facility: Oregon Health and Science University (CHH1)
state: Oregon
city: Portland
country: United States
facility: Oregon Health and Science University (CHH2)
state: Oregon
city: Tigard
country: United States
facility: Northwest Cancer Specialists, P.C.
state: Oregon
city: Tualatin
country: United States
facility: Oregon Health and Science University - CHO Tualatin
state: Oregon
city: Bensalem
country: United States
facility: Alliance Cancer Specialists, PC
state: Pennsylvania
city: Doylestown
country: United States
facility: Alliance Cancer Specialists, PC
state: Pennsylvania
city: Horsham
country: United States
facility: Alliance Cancer Specialists, PC
state: Pennsylvania
city: Langhorne
country: United States
facility: Alliance Cancer Specialists, PC
state: Pennsylvania
city: Media
country: United States
facility: Alliance Cancer Specialists, PC
state: Pennsylvania
city: Sellersville
country: United States
facility: Alliance Cancer Specialists, PC
state: Pennsylvania
city: Wynnewood
country: United States
facility: Alliance Cancer Specialists, PC
state: Pennsylvania
city: Abilene
country: United States
facility: Texas Oncology
state: Texas
city: Amarillo
country: United States
facility: Texas Oncology
state: Texas
city: Austin
country: United States
facility: Texas Oncology
state: Texas
city: Austin
country: United States
facility: Texas Oncology
state: Texas
city: Austin
country: United States
facility: Texas Oncology
state: Texas
city: Beaumont
country: United States
facility: Texas Oncology - Gulf Coast
state: Texas
city: Dallas
country: United States
facility: University of Texas Southwestern Medical Center - Simmons Cancer Center
state: Texas
city: Dallas
country: United States
facility: University Of Texas Southwestern Medical Center
state: Texas
city: Dallas
country: United States
facility: UT Southwestern Medical Center - Redbird
state: Texas
city: Dallas
country: United States
facility: Univ. of TX Southwestern Medical Center - Zale Lipshy University Hospital
state: Texas
city: Dallas
country: United States
facility: University of Texas Southwestern Medical Center - William P. Clements, Jr., University Hospital
state: Texas
city: Dallas
country: United States
facility: University Of Texas Southwestern Medical Center
state: Texas
city: El Paso
country: United States
facility: Texas Oncology
state: Texas
city: Fort Worth
country: United States
facility: UT Southwestern - Simmons Cancer Center - Fort Worth
state: Texas
city: Houston
country: United States
facility: Texas Oncology - Gulf Coast
state: Texas
city: Irving
country: United States
facility: US Oncology Investigational Product Center (IPC)
state: Texas
city: Midland
country: United States
facility: Texas Oncology
state: Texas
city: Odessa
country: United States
facility: Texas Oncology
state: Texas
city: Pearland
country: United States
facility: Texas Oncology - Gulf Coast
state: Texas
city: Richardson
country: United States
facility: UT Southwestern - Simmons Cancer Center - Richardson/Plano
state: Texas
city: Sugar Land
country: United States
facility: Texas Oncology - Gulf Coast
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - Gulf Coast
state: Texas
city: Tyler
country: United States
facility: The University of Texas Health Science Center at Tyler on behalf of UT
state: Texas
city: Tyler
country: United States
facility: The University of Texas Health Science Center at Tyler on behalf of UT
state: Texas
city: Waco
country: United States
facility: Texas Oncology
state: Texas
city: Webster
country: United States
facility: Texas Oncology - Gulf Coast
state: Texas
city: Wichita Falls
country: United States
facility: Texas Oncology
state: Texas
city: Salem
country: United States
facility: Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
state: Virginia
city: Wytheville
country: United States
facility: Oncology & Hematology Associates of Southwest Virginia, INC.
state: Virginia
city: Bonney Lake
country: United States
facility: Northwest Medical Specialties, PLLC
state: Washington
city: Federal Way
country: United States
facility: Northwest Medical Specialties, PLLC
state: Washington
city: Gig Harbor
country: United States
facility: Northwest Medical Specialties, PLLC
state: Washington
city: Olympia
country: United States
facility: American Oncology Network Vista Oncology Division-West office
state: Washington
city: Olympia
country: United States
facility: American Oncology Network Vista Oncology Division
state: Washington
city: Puyallup
country: United States
facility: Northwest Medical Specialties, PLLC
state: Washington
city: Tacoma
country: United States
facility: Northwest Medical Specialties, PLLC
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists, P.C.
state: Washington
city: Milwaukee
country: United States
facility: Froedtert Hospital/Medical College of Wisconsin
state: Wisconsin
city: Cordoba
country: Argentina
facility: CEMAIC - Centro Medico Privado
city: Cordoba
country: Argentina
facility: Sanatorio Allende Cerro
city: Mar del Plata
country: Argentina
facility: Instituto de Investigaciones Clinicas de Mar del Plata
city: Rosario
country: Argentina
facility: Sanatorio Parque
city: Rosario
country: Argentina
facility: Instituto de Oncologia de Rosario
city: Rosario
country: Argentina
facility: Hospital Provincial del Centenario
city: San Juan
country: Argentina
facility: Centro Oncologico de Excelencia
city: Albury
country: Australia
facility: Border Medical Oncology
state: New South Wales
city: Albury
country: Australia
facility: Ramsay Health Care Australia Pty Ltd
state: New South Wales
city: Kingswood
country: Australia
facility: GenesisCare Kingswood
state: New South Wales
city: Waratah
country: Australia
facility: Calvary Mater Newcastle
state: New South Wales
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital
state: Queensland
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Murdoch
country: Australia
facility: St John of God Hospital Murdoch
state: Western Australia
city: Frankston
country: Australia
facility: Frankston Hospital
city: Graz
country: Austria
facility: LKH- Universitat Klinikum Graz
city: Graz
country: Austria
facility: Medizinische Universitat Graz - Universitatsklinik fur Radiologie
city: Graz
country: Austria
facility: Medizinische Universitat Graz
city: Graz
country: Austria
facility: Medizinische Universitat Graz - Diagnostik- & Forschungsinstitut fur Pathologie
city: Graz
country: Austria
facility: Medizinische Universitat Graz - Klinische Abteilung fur Nuklearmedizin
city: Vienna
country: Austria
facility: AKH - Medizinische Universitat Wien
city: Wien
country: Austria
facility: Riedl-Prayer-Drahanowsky-Barton Radiologiegruppenpraxis OG (RPDB)- Imagingpraterstern
city: Brasschaat
country: Belgium
facility: Algemeen Ziekenhuis klina
city: Edegem
country: Belgium
facility: Universitair Ziekenhuis Antwerpen
city: Ghent
country: Belgium
facility: Universitair Ziekenhuis Gent
city: Hasselt
country: Belgium
facility: Jessa Ziekenhuis VZW
city: Liege
country: Belgium
facility: CHU de Liege
city: Santo Andre
country: Brazil
facility: CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
state: SAO Paulo
city: Vila Olímpia
country: Brazil
facility: Centro Paulista de Oncologia S A
state: SAO Paulo
city: Barretos
country: Brazil
facility: Hospital de Cancer de Barretos - Fundacao Pio XII
city: Fortaleza
country: Brazil
facility: Centro Regional Integrado de Oncologia.
city: Ijui
country: Brazil
facility: Oncosite - Centro de Pesquisa Clinica e Oncologia
city: Jaú
country: Brazil
facility: Fundação Doutor Amaral Carvalho.
city: Porto Alegre
country: Brazil
facility: Hospital Mãe de Deus
city: Porto Alegre
country: Brazil
facility: Sao Lucas Hospital of PUCRS
city: Salvador
country: Brazil
facility: Centro de Oncologia da Bahia
city: Calgary
country: Canada
facility: Arthur J.E. Child Comprehensive Cancer Centre
state: Alberta
city: Edmonton
country: Canada
facility: University of Alberta / Cross Cancer Institute
state: Alberta
city: Brampton
country: Canada
facility: Peel Memorial Hospital
state: Ontario
city: East Brampton
country: Canada
facility: William Osler Health Sciences
state: Ontario
city: Etobicoke
country: Canada
facility: Etobicoke General Hospital
state: Ontario
city: Ottawa
country: Canada
facility: Ottawa Hospital Cancer Centre
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Health Sciences Centre
state: Ontario
city: Greenfield Park
country: Canada
facility: CISSS de la Monteregie-Centre
state: Quebec
city: Montreal
country: Canada
facility: Centre Hospitalier de l'Universite de Montreal
state: Quebec
city: Montreal
country: Canada
facility: McGill University Department of Oncology/McGill University Health Centre
state: Quebec
city: Santiago
country: Chile
facility: CeCim Biocinetic
state: Region Metropolitana
city: Providencia
country: Chile
facility: CDIEM - Centro de Investigación y Especialidades Medicas
state: Santiago
city: Vina del Mar
country: Chile
facility: Centro de Investigaciones Clinicas Viña del Mar Ltda.
state: Valparaíso
city: Concepción
country: Chile
facility: BIOCENTER Centro Clínico de Investigación
city: Santiago
country: Chile
facility: Centro de Investigacion Clinica Bradford Hill
city: Hefei
country: China
facility: The First Affiliated Hospital of Anhui Medical University
state: Anhui
city: Fuzhou
country: China
facility: Fujian provincial Cancer Hospital
state: Fujian
city: Foshan
country: China
facility: The First People's Hospital of Foshan
state: Guangdong
city: Guangzhou
country: China
facility: Guangdong General Hospital
state: Guangdong
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
state: Guangdong
city: Jiangmen City
country: China
facility: Jiangmen Central Hospital
state: Guangdong
city: Nanning
country: China
facility: Guangxi Medical University Affiliated Tumor Hospital
state: Guangxi
city: Luoyang
country: China
facility: The First Affiliated Hospital of Henan University of Science &Technology
state: Henan
city: Zhengzhou
country: China
facility: Henan Cancer Hospital
state: Henan
city: Wuhan
country: China
facility: Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
state: Hubei
city: Changsha
country: China
facility: Hunan Cancer Hospital
state: Hunan
city: Nanjing
country: China
facility: Jiangsu Province Hospital
state: Jiangsu
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University
state: Jiangxi
city: Changchun
country: China
facility: Jilin Cancer Hospital
state: Jilin
city: Jinan
country: China
facility: Shandong Cancer Hospital
state: Shandong
city: Linyi
country: China
facility: LinYi Cancer Hospital
state: Shandong
city: Taiyuan
country: China
facility: Shanxi Bethune Hospital
state: Shanxi
city: Chengdu
country: China
facility: Sichuan Province Cancer Hospital
state: Sichuan
city: Tian Jin
country: China
facility: Tianjin Cancer Hospital
state: TIAN JIN
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital
state: Zhejiang
city: Taizhou
country: China
facility: Taizhou Hospital of Zhejiang Province
state: Zhejiang
city: Beijing
country: China
facility: Beijing Cancer Hospital
city: Beijing
country: China
facility: Beijing Chest Hospital, Capital Medical University
city: Chongqing
country: China
facility: Chongqing University Cancer Hospital
city: Shanghai
country: China
facility: Fudan University Shanghai Cancer Center
city: Olomouc
country: Czechia
facility: Fakultni nemocnice Olomouc, Onkologicka klinika
city: Ostrava
country: Czechia
facility: Nemocnice AGEL Ostrava Vitkovice a.s.,
city: Praha 2
country: Czechia
facility: Onkologicka klinika VFN
city: Toulon
country: France
facility: Chits Sainte Musse
state: VAR
city: Besancon
country: France
facility: CHU de Besancon - Hopital Jean Minjoz
city: Cholet
country: France
facility: Centre Hospitalier de Cholet
city: Creteil
country: France
facility: Centre Hospitalier Intercommunal Creteil - CHI Creteil
city: Lille
country: France
facility: CHRU de Lille
city: Marseille
country: France
facility: Hopital Nord Marseille
city: Montpellier
country: France
facility: Centre de Cancerologie du Grand Montpellier
city: Montpellier
country: France
facility: Service UPCC, R-1, Clinique Clementville
city: Paris
country: France
facility: Hopital Cochin, APHP Centre Universite de Paris
city: Paris
country: France
facility: Hopital Bichat-Claude Bernard - APHP
city: Pessac
country: France
facility: CHU Bordeaux Hopital Haut-Leveque
city: Quimper
country: France
facility: CH de Cornouaille
city: Rennes Cedex 9
country: France
facility: Centre Hospitalier Universitaire de Rennes, Hopital Pontchaillou
city: Strasbourg
country: France
facility: Institut de Cancerologie Strasbourg Europe
city: Toulouse
country: France
facility: CHU Toulouse - Hopital Larrey
city: Villejuif
country: France
facility: IGR Gustave Roussy
city: Bonn
country: Germany
facility: Johanniter Krankenhaus Bonn
city: Esslingen
country: Germany
facility: Klinikum Esslingen GmbH
city: Frankfurt
country: Germany
facility: Universitatsklinkik Frankfurt
city: Gauting
country: Germany
facility: Asklepios Klinik Gauting GmbH
city: Grosshansdorf
country: Germany
facility: LungenClinic Grosshansdorf
city: Halle
country: Germany
facility: Krankenhaus Martha-Maria Halle Dölau gGmbH Klinik für Innere Medizin II
city: Heidelberg
country: Germany
facility: Thoraxklinik Heidelberg gGmbH
city: Kassel
country: Germany
facility: Klinikum Kassel GmbH
city: Luebeck
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein, Campus Luebeck
city: Luebeck
country: Germany
facility: Universitatsklinikum Schleswig-Holstein, Campus Lubeck
city: Munster
country: Germany
facility: Universitaetsklinikum Muenster (UKM)
city: Larissa
country: Greece
facility: University Hospital of Larissa
state: Thessaly
city: Athens
country: Greece
facility: Henry Dunant Hospital Center
city: Athens
country: Greece
facility: Alexandra General Hospital of Athens.
city: Cholargos
country: Greece
facility: Metropolitan General Hospital.
city: N.Faliro
country: Greece
facility: Metropolitan Hospital
city: Patras
country: Greece
facility: General University Hospital of Patras
city: Pilea
country: Greece
facility: Interbalkan Medical Center
city: Thessaloniki
country: Greece
facility: St. Luke's Hospital
city: Budapest
country: Hungary
facility: Affidea Diagnosztika Kft.
city: Budapest
country: Hungary
facility: Semmelweis Egyetem
city: Budapest
country: Hungary
facility: National Koranyi Institute of Pulmonology
city: Budapest
country: Hungary
facility: Orszagos Koranyi Pulmonologiai Intezet
city: Farkasgyepu
country: Hungary
facility: Farkasgyepui Tudogyogyintezet
city: Veszprem
country: Hungary
facility: TritonLife Diagnosztikai
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center
state: Other
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
city: Kfar Saba
country: Israel
facility: Meir Medical Center
city: Petah Tikva
country: Israel
facility: Rabin Medical Center
city: Rehovot
country: Israel
facility: Kaplan Medical Center
city: Torrette (AN)
country: Italy
facility: A.O.U. - Ospedali Riuniti di Ancona
state: Ancona
city: Caserta
country: Italy
facility: Azienda Ospedaliera di Rilievo Nazionale Sant'Anna e San Sebastiano
state: Campania
city: Meldola
country: Italy
facility: IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino Amadori- IRST S.r.l
state: Emilia-romagna
city: Roma
country: Italy
facility: Policlinico Universitario Agostino Gemelli
state: Lazio
city: Milano
country: Italy
facility: Ospedale San Raffaele
state: Lombardy
city: Milano
country: Italy
facility: Fondazione IRCCS Istituto Nazionale Dei Tumori
state: Lombardy
city: Monza
country: Italy
facility: U.O.C. Centro di Ricerca di Fase 1, Fondazione IRCCS San Gerardo dei Tintori
state: MB
city: Monza
country: Italy
facility: U.O.C. Oncologia Medica, Fondazione IRCCS San Gerardo dei Tintori
state: MB
city: Aviano
country: Italy
facility: Centro di Riferimento Oncologico Di Aviano
state: Pordenone
city: Brescia
country: Italy
facility: Azienda Ospedaliera Spedali Civili di brescia
state: Province OF Brescia
city: Roma
country: Italy
facility: Farmacia
state: Rome
city: Roma
country: Italy
facility: Oncologia Medica 2
state: Rome
city: Catania
country: Italy
facility: A.O.U Policlinico G. Rodolico S. Marco
state: Sicily
city: Catania
country: Italy
facility: G Rodolico AOU Policlinico - S. Marco
city: Genova
country: Italy
facility: Clinica di Oncologia Medica Policlinico San Martino
city: Parma
country: Italy
facility: UOC Oncologia Medica - Azienda Ospedaliero - Universitaria di Parma
city: Rome
country: Italy
facility: Radiologia
city: Nagoya-shi
country: Japan
facility: Aichi Cancer Center
state: Aichi
city: Kashiwa-shi
country: Japan
facility: National Cancer Center Hospital East
state: Chiba
city: Matsuyama-shi
country: Japan
facility: NHO Shikoku Cancer Center
state: Ehime
city: Kurume
country: Japan
facility: Kurume University Hospital
state: Fukuoka
city: Kobe-shi
country: Japan
facility: Kobe City Hospital Organization Kobe City Medical Center General Hospital
state: Hyōgo
city: Kanazawa-shi
country: Japan
facility: Kanazawa University Hospital
state: Ishikawa
city: Yokohama
country: Japan
facility: Kanagawa Cancer Center
state: Kanagawa
city: Niigata-shi
country: Japan
facility: Niigata Cancer Center Hospital
state: Niigata
city: Osakasayama
country: Japan
facility: Kindai University Hospital
state: Osaka
city: Takatsuki-shi
country: Japan
facility: Osaka Medical and Pharmaceutical University Hospital
state: Osaka
city: Osaka
country: Japan
facility: Osaka International Cancer Institute
state: Other
city: Sunto-gun
country: Japan
facility: Shizuoka Cancer Center
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Nippon Medical School Hospital
state: Tokyo
city: Bunkyo-ku
country: Japan
facility: Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital
state: Tokyo
city: Chuo-ku
country: Japan
facility: National Cancer Center Hospital
state: Tokyo
city: Koto-ku
country: Japan
facility: The Cancer Institute Hospital of JFCR
state: Tokyo
city: Ota-shi
country: Japan
facility: Gunma Prefectural Cancer Center
state: Tokyo
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
state: Other
city: Suwon-si
country: Korea, Republic of
facility: St. Vincent's Hospital, The Catholic University of Korea.
state: Other
city: Suwon-si
country: Korea, Republic of
facility: Ajou University Hospital.
state: Other
city: Jeonju-si
country: Korea, Republic of
facility: Jeonbuk National University Hospital
city: Suwon-si
country: Korea, Republic of
facility: Ajou University Hospital
city: Groningen
country: Netherlands
facility: Martini Ziekenhuis
city: Maastricht
country: Netherlands
facility: Maastricht UMC
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum Daniel Den Hoed
city: Drammen
country: Norway
facility: Vestre Viken Health Trust - Drammen Hospital
city: Oslo
country: Norway
facility: Oslo University Hospital (OUH) - The Norwegian Radium Hospital
city: Oslo
country: Norway
facility: Sykehusapoteket Oslo, Radiumhospitalet - Avdeling Produksjon
city: Trondheim
country: Norway
facility: Kreftklinikken, St.Olavs hospital
city: GdaDsk
country: Poland
facility: Medical University of Gdansk
state: Other
city: Lodz
country: Poland
facility: Instytut MSF Sp. z.o.o.
city: Lublin
country: Poland
facility: Institute of Genetics and Immunology GENIM LCC
city: Poznan
country: Poland
facility: Med-Polonia Sp. z.o.o.
city: Cluj-Napoca
country: Romania
facility: Institutul Oncologic "Prof. Dr. I. Chiricuta" Cluj-Napoca
state: Koblenz
city: Bucuresti
country: Romania
facility: SC Policlinica CCBR SRL
city: Bucuresti
country: Romania
facility: Spitalul de Oncologie Monza SRL
city: Cluj-Napoca
country: Romania
facility: Medisprof Cancer Center
city: Constanta
country: Romania
facility: Ovidius Clinical Hospital S.R.L
city: Craiova
country: Romania
facility: Centrul de Oncologie Sf Nectarie
city: Timisoara
country: Romania
facility: Oncocenter-Oncologie Clinica SRL
city: Alicante
country: Spain
facility: Hospital General Universitario Alicante
state: Comunidad Valenciana
city: Palma
country: Spain
facility: Hospital Universitario Son Espases
state: Islas Baleares
city: Barcelona
country: Spain
facility: CETIR Viladomat
state: Other
city: A Coruna
country: Spain
facility: Complejo Hospitalario Universitario La Coruna
city: Alicante
country: Spain
facility: Hospital General Universitario de Alicante - Farmacia
city: Badalona
country: Spain
facility: lnstitut Catala D'oncologia (ICO) Badalona - Hospital Universitari Germans Trias I Pujol
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron
city: Castello de la Plana
country: Spain
facility: Consorcio Hospitalario Provincial de Castellon
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Maranon
city: Madrid
country: Spain
facility: Hospital Clinico San Carlos
city: Madrid
country: Spain
facility: Servicio de Farmacia Hospitalaria
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Malaga
country: Spain
facility: Hospital Quironsalud Malaga
city: Valencia
country: Spain
facility: Fundación Instituto Valenciano de Oncología (FIVO)
city: Valencia
country: Spain
facility: Hospital Universitari i Politecnic La Fe
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa de Zaragoza
city: Chur
country: Switzerland
facility: Kantonsspital Graubunden,Onkologie und Hamatologie
state: Graubünden (DE)
city: Chur
country: Switzerland
facility: Kantonsspital Graubuenden
state: Other
city: Basel
country: Switzerland
facility: Universitatsspital Basel
city: Bern
country: Switzerland
facility: Inselspital
city: Chur
country: Switzerland
facility: Kantonsspital Graubunden
city: Lausanne
country: Switzerland
facility: University Hospital Lausanne CHUV
city: Zurich
country: Switzerland
facility: Universitatsspital Zurich, Institut fur diagnostische und interventionelle Radiologie
city: Zurich
country: Switzerland
facility: Universitatsspital Zurich
city: Zurich
country: Switzerland
facility: Universitatsspital Zurich
city: Douliou City
country: Taiwan
facility: National Taiwan University Hospital Yunlin Branch
state: Other
city: Changhua
country: Taiwan
facility: Changhua Christian Medical Foundation Changhua Christian Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Hospital
city: Kaohsiung
country: Taiwan
facility: E-Da Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: London
country: United Kingdom
facility: Diagnostic Centre
state: Others
city: London
country: United Kingdom
facility: The Harley Street Clinic (THSC)
state: Other
city: Glasgow
country: United Kingdom
facility: The Beatson West of Scotland Cancer Centre
city: Leeds
country: United Kingdom
facility: Leeds Teaching Hospitals Trust
city: London
country: United Kingdom
facility: St. Bartholomew's Hospital - Barts Health NHS Trust
city: London
country: United Kingdom
facility: The Royal Marsden NHS Foundation Trust (RM).
city: London
country: United Kingdom
facility: The Royal Marsden NHS Foundation Trust (RM)
city: London
country: United Kingdom
facility: Sarah Cannon Research Institute UK
city: London
country: United Kingdom
facility: The Harley Street Clinic
city: London
country: United Kingdom
facility: The Harley Street Clinic
city: Manchester
country: United Kingdom
facility: The Christie NHS Foundation Trust
city: Sutton
country: United Kingdom
facility: Royal Marsden Hospital Sutton
city: Sutton
country: United Kingdom
facility: The Royal Marsden NHS Foundation Trust (RM)
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References: