louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05155358: Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
Official title: Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Heat Stroke
Early Waking
MODS
Proteinosis
Liver Injury
Kidney Injury
Lead sponsor: Xijing Hospital
Sponsor class: OTHER
First posted: 2021-12-13
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 1. Healthy Volunteers with routine physical examination;
2. Heat stroke is defined as heat stroke (Heat Stroke, HS) is a serious fatal disease caused by heat injury factors acting on the body, accompanied by multiple organ(liver,kindey, lung ect) dysfunction.

Brief summary: Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs. At present, there is no unified diagnostic criteria for acute liver injury associated with heat stroke, and the commonly used prognosis scores are rarely included in liver injury indicators, which is not good for practicality.

Detailed description: The project intends to collect the peripheral blood of the normal population, the 24 hours after the onset of heat stroke and the patients in the recovery period, to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to search for indicators related to disease deterioration and prognosis, construct and verify the early warning and prognosis evaluation system of the disease.

On this basis, the researcher explore cellular and molecular mediated pathological mechanisms of heat stroke, and then clarify the treatment target of heat stroke.

Eligibility criteria: Inclusion Criteria:

1. The patient voluntarily signs an informed consent form;
2. Adult patients who meet the criteria for heat stroke;
3. Heat stroke is defined as heat stroke (Heat Stroke, HS) is a serious fatal disease caused by heat injury factors acting on the body, accompanied by multiple organ damage.

Exclusion Criteria:

1. Age \<18 years old or \>90 years old;
2. Patients with advanced tumors, Pregnancy or lactation;
3. Patients who missed out during treatment and whose data are incomplete.

Primary outcomes:
measure: Prognosis
timeFrame: Day 30 and Day 90
Secondary outcomes:
measure: Heat Stroke-associated kindey injury
timeFrame: Day 0, Day 7 and On the day of discharge after improvement
measure: Heat Stroke-associated liver injury
timeFrame: Day 0, Day 7 and On the day of discharge after improvement
Other outcomes:
Locations:
city: Xi'an
country: China
facility: The First Affillated Hospital,the Air Force Medical University
state: Shannxi
Study officials:
affiliation: The First Affillated Hospital,the Air Force Medical University
name: Yanyan Jia
role: STUDY_CHAIR
References:
Clinical trial NCT04396158: Effect of Radioiodine Therapy on Ovarian Reserve in Female Patients With Differentiated Thyroid Cancer
Official title: Effect of Radioiodine Therapy on Ovarian Reserve in Female Patients With Differentiated Thyroid Cancer
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Ovarian Insufficiency
Radiation Exposure
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-05-20
Enrollment: 38
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 45
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: self controlled case series
Primary purpose: DIAGNOSTIC

Brief summary: Thyroid carcinoma is the most common endocrine malignancy. Surgery is the standard therapeutic approach for patients with differentiated thyroid carcinoma (DTC), followed by radioiodine (RAI) therapy if indicated. For women with DTC, the effects of RAI therapy on gonadal and reproductive function are an important consideration. This study aimed to evaluate the effects of RAI therapy on ovarian function.


Eligibility criteria: Inclusion Criteria:

* Female patient in childbearing period.
* Female patient with differentiated thyroid carcinoma.
* Underwent thyroidectomy.
* Candidate for radioactive iodine therapy.

Exclusion Criteria:

* • Male patients.

  * Postmenopausal female patients.
  * Female patients with undifferentiated thyroid carcinoma.
  * Pregnant female patients.
  * Lactating female patients.

Primary outcomes:
measure: Level of anti-Müllerian (AMH) hormone
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06395558: intErnet-based iNterventions FOR Cardiac arrEst suRvivors
Official title: Internet-Based Interventions for Cardiac Arrest Survivors
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cognitive Impairment
Depression, Anxiety
Cardiac Arrest
Quality of Life
Social Functioning
Sexual Dysfunction
Lead sponsor: Azienda Usl di Bologna
Sponsor class: OTHER_GOV
Collaborators: name: Montecatone Rehabilitation Institute S.p.A.
First posted: 2024-05-02
Enrollment: 137
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Anxiety, depression and cognitive impairment symptoms are common among cardiac arrest survivors. This randomized clinical trial will test whether an internet-based lifestyle intervention administered through a web app can foster anxiety and depression symptoms in patients who survived an out-of-hospital cardiac arrest and suffer from these symptoms


Eligibility criteria: Inclusion Criteria:

* Hospital discharge after out-of-hospital cardiac arrest with Cerebral Performance Category 1 or 2
* HADS anxiety or depression ≥ 8 and/or TICS ≤ 31
* Informed consent for participation in the study
* Native Italian speaker or adequate understanding of the Italian language
* Adequate ability to use the web to guarantee access to the contents

Exclusion Criteria:

* Previous cognitive dysfunction
* Previous psychiatric disease
* Previous episode of out-of-hospital cardiac arrest

Primary outcomes:
measure: Composite outcome
timeFrame: 12 months
Secondary outcomes:
measure: HADS (Hospital Anxiety and Depression Scale) value
timeFrame: 12 months
measure: TICS (Telephone Interview for Cognitive Status)
timeFrame: 12 months
measure: SF-12 (Short Form Health Survey 36)
timeFrame: 12 months
measure: NRS (Neurobehavioural rating scale), PCRS (Patient Competency Rating Scale)
timeFrame: 12 months
measure: NRS (Neurobehavioural rating scale)
timeFrame: 12 months
measure: Pittsburgh Sleep Quality Index (PSQI)
timeFrame: 12 months
measure: Sexual Interest and Satisfaction Scale (SISS)
timeFrame: 12 months
measure: Zarit Burden Inventory (ZBI)
timeFrame: 12 months
measure: PCRS (Patient Competency Rating Scale)
timeFrame: 12 months
measure: HADS (Hospital Anxiety and Depression Scale) - Caregiver
timeFrame: 12 months
measure: PSQI (Pittsburgh Sleep Quality Index) - Caregiver
timeFrame: 12 months
measure: SF-12 (Short Form Health Survey 36) - Caregiver
timeFrame: 12 months
Other outcomes:
Locations:
city: Imola
country: Italy
facility: Montecatone Rehabilitation Institute
state: Bologna
city: Bologna
country: Italy
facility: Azienda Unità Sanitaria Locale
Study officials:
affiliation: Azienda USL Bologna
name: Lorenzo Gamberini, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05134558: Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment
Official title: Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment: Functional Protection of the Lung and Prevention of Radiation Pneumonitis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Lung Cancer
Radiation Therapy Complication
Keywords: lung cancer
Radiation Therapy
Xenon-enhanced ventilation CT
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2021-11-26
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Detailed description: There has been an increase in the application of radiation therapy in the treatment of lung tumors; however, the associated side effect, called radiation pneumonitis, can significantly reduce lung function and the quality of life of patients, eventually leading to fatal consequences. The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Eligibility criteria: Inclusion Criteria:

* Patients aged 20-80 years, with lung cancer receiving thoracic radiotherapy in NTUH, from February 2020 to December 2024.

Exclusion Criteria:

* The age is less than 20 years old or older than 80 years old.
* Unstable clinical condition, unable to maintain apnea for 15 second, and history of prior adverse reaction to xenon.
* Renal insufficiency patients.
* Claustrophobia
* Those who are pregnant.

Primary outcomes:
measure: Incidence of radiation pneumonia
timeFrame: Within 1 year of radiation therapy
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
References:
Clinical trial NCT06409858: Efficacy Testing of Les Mills Pilates
Official title: Efficacy Testing of Les Mills Pilates
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Core Muscle Endurance
Lead sponsor: University of the Fraser Valley
Sponsor class: OTHER
Collaborators: name: Les Mills International
First posted: 2024-05-10
Enrollment: 25
Sex: ALL
Minimum age (years): 19
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Objectives: Determine the effect of an 8-week intervention of the new group fitness program Les Mills Pilates on balance, core stability, abdominal, back, and hip muscle endurance, flexibility, and mood. Research questions: Does doing Les Mills Pilates twice per week for 8 weeks result in: 1) increased balance, 2) increased core stability, 3) increased abdominal, back, and hip muscle endurance, 4) increased flexibility, and 5) improved mood? Intended outcomes: this study will determine the efficacy of a new group fitness program developed by Les Mills International. Results will be used to help refine the program, as well as in marketing of the program.


Eligibility criteria: Inclusion Criteria:

* Not participating in regular core training (no more than 10 minutes per session, twice per week)
* Active (150 minutes per week of moderate to vigorous physical activity)

Exclusion Criteria:

* any neurological, cardiovascular, or musculoskeletal conditions that would put them at risk while participating, or be made worse by exercise
* Participants with current lower back pain
* Pregnant participants

Primary outcomes:
measure: Core endurance (time to failure in seconds)
timeFrame: 8 weeks
Secondary outcomes:
measure: Balance (single leg reach distance in cm)
timeFrame: 8 weeks
measure: Core stability: Sahrmann trunk stability test
timeFrame: 8 weeks
measure: Flexibility in cm
timeFrame: 8 weeks
measure: Mood
timeFrame: Daily for 8 weeks
Other outcomes:
Locations:
Study officials:
affiliation: University of the Fraser Valley
name: Gillian L Hatfield, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04154358: Implementing HPV DNA Self-Collection to Increase Rates of Cervical Cancer Screening in Transgender Men
Official title: Implementing HPV DNA Self-Collection to Increase Rates of Cervical Cancer Screening in Transgender Men
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Transgenderism
Cervical Cancer
Human Papilloma Virus
Lead sponsor: Augusta University
Sponsor class: OTHER
Collaborators: name: The Equality Clinic of Augusta
First posted: 2019-11-06
Enrollment: 100
Sex: FEMALE
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: Transgender men are individuals born genetically female that have a gender identity that is incongruent with their biological sex. For those who have begun or completed transition, they may present as males but still have a uterus and cervix. Thus far, no distinction has been made between routine cervical cancer screening guidelines in non-transgender women and those for transgender men, despite wide variations in sexual practices, including lifelong vaginal abstinence. The purpose of this study is to offer transgender men seen at clinic visits self-collected HPV testing to evaluate for improved cervical cancer screening rates, as well as a survey to further investigate sexual practices, rates of appropriate screening prior to being offered self-collection, and barriers to obtaining appropriate care.


Eligibility criteria: Inclusion Criteria:

* Age \>21 for survey and age\> 25 for HPV testing
* Transgender male or gender non-conforming identity
* Female sex at birth
* Consent to participate in the study

Exclusion Criteria:

* impaired decision making capacity
* Absence of cervix
* Non-English speaking

Primary outcomes:
measure: Rate of cervical cancer screening
timeFrame: 1 year
Secondary outcomes:
measure: incidence of barriers to care
timeFrame: 1 year
measure: incidence of high risk sexual practices
timeFrame: 1 year
measure: rate of HPV vaccination
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03623958: Image Guided VATS vs. VATS Resection
Official title: Image Guided VATS Resection vs. VATS Resection of Lung Lesions
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Lung Cancer
Keywords: image guided
lung nodule
lung cancer
lung mass
Lead sponsor: Brigham and Women's Hospital
Sponsor class: OTHER
First posted: 2018-08-09
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate workflow and outcomes of iVATS and standard VATS for small pulmonary nodules. The outcomes of the patients will be evaluated separately as there will be no direct comparison of the two arms.

Detailed description: This is a prospective phase II clinical study to evaluate iVATS and standard VATS for small pulmonary nodules. We have successfully completed and published a phase I/pilot study with 25 patients demonstrating safety and optimal procedural workflow for combining image-guidance with VATS. This phase II clinical study will further expand upon the safety and feasibility of this procedure. Additionally, this data will be used to design a phase III comparison study between iVATS and standard VATS.

Eligibility criteria: Inclusion Criteria:

* Subject must be 18 years and older
* Subject must be deemed a candidate for the iVATS surgery, by their treating Thoracic Surgeon
* Subject must have nodules/GGO or other abnormal opacity that can be accurately measured in at least one dimension with longest diameter ≤ 20 mm or 2cm
* Subject's lesions that are located in the outer half portion of the lung/lobe.
* Subjects must be evaluated at BWH and/or DFCI Thoracic Surgery outpatient clinics

Exclusion Criteria:

* If participant is a pregnant woman or breast feeding they will not be eligible.
* If treating thoracic surgeon deems the participant not eligible for the study.

Primary outcomes:
measure: Operating Room Time
timeFrame: 3 years to complete
Secondary outcomes:
measure: Time to T-bar placement
timeFrame: 3 years
measure: Time for induction to incision
timeFrame: 3 years
measure: Hospital Length of Stay
timeFrame: 3 years
measure: Radiation Exposure
timeFrame: 3 years
Other outcomes:
measure: Quantitative Analysis of CT scans
timeFrame: 3 years
Locations:
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
Study officials:
affiliation: Brigham and Women's Hospital
name: Raphael Bueno, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gill RR, Zheng Y, Barlow JS, Jayender J, Girard EE, Hartigan PM, Chirieac LR, Belle-King CJ, Murray K, Sears C, Wee JO, Jaklitsch MT, Colson YL, Bueno R. Image-guided video assisted thoracoscopic surgery (iVATS) - phase I-II clinical trial. J Surg Oncol. 2015 Jul;112(1):18-25. doi: 10.1002/jso.23941. Epub 2015 May 28.
Clinical trial NCT01839058: Is Non-Cardiac Chest Pain Caused by Sustained Longitudinal Smooth Muscle Contraction?
Official title: Is Non-Cardiac Chest Pain Caused by Sustained Longitudinal Smooth Muscle Contraction?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chest Pain Atypical Syndrome
Keywords: Non Cardiac Chest Pain
Lead sponsor: Queen's University
Sponsor class: OTHER
First posted: 2013-04-24
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with non cardiac chest pain as diagnosed by cardiologist or other physician. Healthy Volunteers will include anyone in the Kingston area who fulfils Inclusion and Exclusion criteria.

Brief summary: Non-cardiac chest pain (NCCP) is a common disorder whose pathophysiology is poorly understood. Some evidence suggests it may be related to sustained esophageal contractions (SECs) of longitudinal smooth muscle. The investigators have previously shown that acid is a trigger for SECs and results in shortening of the esophagus. In this study, the investigators plan to prospectively evaluate esophageal shortening responses to acid in a group of patients with NCCP compared to controls. The investigators will use high resolution esophageal manometry coupled with acid infusion to evaluate shortening. The investigators hypothesize that at least a subset of patients with NCCP will have an exaggerated esophageal shortening response to acid which correlates with symptom production. If our hypothesis proves true, this may lead to a future therapeutic target in the treatment of these patients.


Eligibility criteria: Inclusion Criteria:

* Healthy volunteers:
* free of esophageal symptoms
* not on any acid suppressing medications
* Non Cardiac Chest Pain Patients:
* Angina like chest pain occuring at least once per month
* Coronary artery disease ruled out by stress test or angiogram

Exclusion Criteria:

* pre existing motility disorder of the esophagus
* connective tissue disease
* pregnancy
* taking calcium channel blockers, Nitrates, Gabapentin, Narcotics, Tricyclic antidepressants, Anti seizure medications

Primary outcomes:
measure: Mean Change in Esophageal Length With Acid
timeFrame: Length at T= 20 minutes - Baseline (T=0)
Secondary outcomes:
measure: Esophageal Length at Symptom Onset
timeFrame: 20 minutes
measure: Esophageal Length at Maximal Symptom Intensity
timeFrame: 20 minutes
measure: Number of Participants for Whom a Correlation Was Found Between Symptom Onset and Esophageal Shortening
timeFrame: 20 minutes
Other outcomes:
Locations:
city: Kingston
country: Canada
facility: Hotel Dieu Hospital
state: Ontario
Study officials:
affiliation: Queen's University
name: William Paterson, MD, FRCPC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00338858: The Connection Between Gait Variability Parameters and Balance Performance in Children With Physical Disability
Official title: The Connection Between Gait Variability Parameters and Balance Performance in Children With Physical Disability
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Brain Injury
Cerebral Palsy
Lead sponsor: Alyn Pediatric & Adolescent Rehabilitation Hospital
Sponsor class: OTHER
First posted: 2006-06-20
Enrollment: 60
Sex: ALL
Minimum age (years): 3
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to explore the connection between gait variability parameters and balance performance in children with physical disability

Detailed description: Step length and step time variability will be measured with an electronic walkway, strength of 4 lower-extremity muscle groups will be tested bilaterally with a hand held dynamometer, walking performance as will be assessed by the 2 minute walk test, energy expenditure index (EEI) and rating of perceived exertion (OMNI scale).

Eligibility criteria: Inclusion Criteria:

3 years of age and older Ambulate, with or without an aid

-

Exclusion Criteria:

-

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Alyn Pediatric and Adolescent Rehabilitation Center
Study officials:
affiliation: Alyn Hospital
name: Hemda Rotem, PT
role: PRINCIPAL_INVESTIGATOR
References: