Clinical trial NCT06952946: Effect of Fresh Gas Flow Differences on Postoperative Nausea and Vomiting
Official title: Effects of Different Fresh Gas Flow Applications on Postoperative Nausea and Vomiting in Septorhinoplasty Surgeries
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Nausea and Vomiting, Postoperative
Septoplasty/Septorhinoplasty
Keywords: fresh gas flow
low flow anesthesia
postoperative nausea vomiting
Lead sponsor: Adiyaman University Research Hospital
Sponsor class: OTHER
First posted: 2025-05-01
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Three groups to which fresh gas flow is applied as low flow (0.5 l/min), medium flow (2 l/min) and high flow (4 l/min).
Primary purpose: PREVENTION

Brief summary: The aim of this study is to investigate the effect of fresh gas flow applied during general anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing septorhinoplasty surgery. Patients who agree to participate in the study will be divided into three groups according to the fresh gas flow applied: low flow (0.5 lt/min) (Group L), medium flow (2 lt/min) (Group M) and high flow (4 lt/min) (Group H), and the postoperative nausea and vomiting data of the groups will be compared.

Detailed description: Preoperative demographic characteristics and Apfel score (smoking history, gender, postoperative opioid use, POB history) of the patients will be recorded. General anesthesia will be applied to all patients with standard ASA monitoring. In general anesthesia induction, 2 mg/kg propofol, 1 mcg/kg remifentanil, 0.6 mg/kg rocuronium will be used for all patients. Sevoflurane (minimum alveolar concentration of 1) will be used as a volatile agent and remifentanil (0.1 mcg-1 mcg/kg/h) will be used as an analgesic agent for anesthesia maintenance. After endotracheal intubation, fresh gas flow will be applied at 4 lt/min for 8 minutes, reduced to 0.5 lt/min in Group L, 2 lt/min in Group M, and maintained at 4 lt/min in Group H. After extubation, patients will be monitored in the recovery unit for at least 30 minutes, and at postoperative 0th minute (when first seen in the recovery room), 30th minute, 1st hour, 6th hour, 12th hour and 24th hour, the nausea score of the patients will be evaluated using the Numerical Rating Scale (NRS) with a score between 0 and 10. If vomiting is present, the number of times the patient vomited will be questioned and recorded. The patients' postoperative VAS scores, the amount of antiemetics used, the amount of opioids used intraoperatively and postoperatively will be recorded, and comparisons will be made between the groups and evaluated.

Eligibility criteria: Inclusion Criteria:

* Patients who agreed to participate in the study
* 18-65 years of age
* ASA I-II risk group patients

Exclusion Criteria:

* Patient does not accept the study
* Presence of psychiatric disorder and patient's inability to cooperate
* Cognitive dysfunction
* Hearing problems
* History of alcohol or drug addiction
* Presence of a serious pre-existing medical condition that limits objective assessment
* Complications developed during surgery
* Presence of any life-threatening condition after surgery
* Patient's classification is ASA III-IV

Primary outcomes:
measure: postoperative nausea and vomiting
timeFrame: 24 hours
Secondary outcomes:
measure: intraoperative body temperature
timeFrame: intraoperative
measure: Whether kidney functions are affected
timeFrame: 1 hour postoperative
measure: whether liver functions are affected
timeFrame: 1 hour postoperative
Other outcomes:
Locations:
city: Adıyaman
country: Turkey
facility: Adıyaman Training and Research Hospital
state: Merkez
Study officials:
References: