Clinical trial NCT02112695: Opioid System Cerebral Activity in Endurance Sportswomen - Addiction or Denutrition ? [11C]Diprenorphine PET Study
Official title: Opioid System Cerebral Activity in Endurance Sportswomen - Addiction or Denutrition ? [11C]Diprenorphine PET Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sports Nutritional Sciences
Keywords: endurance sportswomen
addiction
undernutrition
[11C]diprenorphine Pet
pituitary region
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
Collaborators: name: Ministry of Health, France
First posted: 2014-04-14
Enrollment: 35
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Abnormal opioid system have been identified in addictive behavior and activity of the opioid system has also shown a strong link with the nutritional balance. A significant increase in endorphin levels was noticed after exercise, proportional to the duration and intensity of this activity. One brain imaging study showed an increase in opioid activity in athletes after endurance training. However , a decrease in opioid tone related to receptor desensitization in the brain has been raised in the sport and it is possible to feel like , the subject must perform physical exercise more frequently . Consequently, in order to deepen the hypothesis of addiction in high-level sport , the brain opioid activity should be assessed pre- training compared to a group of sedentary control subjects .

Preliminary results of a previous study the investigators are conducting on anorexia nervosa (AN ) show abnormalities that appear to be involved in self addiction anorexia nervosa and the regulation of gonadal function. However, the relation of cause and effect between these anomalies and undernutrition remains to be determined . Given the addictive component in the endurance sport and the variability of the nutritional status of its practitioners , evaluation of brain activity in these subjects could provide additional answers.


Eligibility criteria: Inclusion Criteria:

For High-level sportswomen :

* 18-35-year-old
* High-level sportswomen
* BMI\>19kg/m2
* Absence of eating disorders
* In pre-competition period
* Signature of written consent

For controls :

* 18-35-year-old
* Sedentary normal weight women
* BMI\>19kg/m2
* Normal nutritional markers
* Absence of eating disorders or other psychiatric or organic diseases

Exclusion Criteria:

* Oral contraception
* Heart failure
* Neuroleptics, antiparkinson drugs, alpha-methyl-dopa, beta blockers, inhibitors of monoamine oxidase-A or MOA-B, tricyclic antidepressants, selective serotonin reuptake inhibitor, thyme-regulators (lithium), anticonvulsant drugs, codeine, morphine, drugs containing tramadol, dopaminergic drugs

Primary outcomes:
measure: [11C]diprenorphine binding potential
timeFrame: 2 weeks
Secondary outcomes:
measure: correlation [11C]diprenorphine BP
timeFrame: 2 weeks
measure: correlation [11C]diprenorphine BP
timeFrame: 2 weeks
measure: correlation [11C]diprenorphine BP
timeFrame: 2 weeks
measure: correlation [11C]diprenorphine BP
timeFrame: 2 weeks
Other outcomes:
Locations:
city: Saint-Etienne
country: France
facility: Service d'Endocrinologie - CHU Saint-Etienne
Study officials:
affiliation: CHU SAINT-ETIENNE
name: Bruno Estour, PU-PH
role: PRINCIPAL_INVESTIGATOR
References: