Clinical trial NCT05942144: Exercise-snacks at Work: Impact on Cardiometabolic Parameters
Official title: Exercise-snacks: an Effective Strategy to Break Sitting Time and Improve Cardiometbaolic Health in Sedentary Overweight Office Workers
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Sedentary Time
Overweight and Obesity
Work-Related Condition
Keywords: brief intense exercise
vascular function
cardiorespiratory fitness
Lead sponsor: University of Avignon
Sponsor class: OTHER
First posted: 2023-07-12
Enrollment: 23
Sex: ALL
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The main objective is to measure the effects of intense brief exercise program in the workplace of administrative staff on the cardio-metabolic health

Detailed description: Backgrounds: Very short (\< 1 minute) and intense exercises, entitled "exercise-snacks", have been reported to be effective 1) in improving physical fitness over 6 weeks and 2) in improving vascular function and lowering blood glucose levels over one day. These studies were all carried out in the laboratory. The question therefore arises as to whether these acute vascular and metabolic benefits, as well as those on physical fitness, are sustainable over time following a chronic "exercise-snacks" program applicable in the professional environment to sedentary, overweight people.

Aims of this project is therefore to measure the effects of an "exercise-snacks" type physical activity program in the workplace of administrative staff on the cardio-metabolic health and sedentary behaviour of staff.

Eligibility criteria: Inclusion Criteria:

* administrative staff,
* age between 30 and 60,
* body mass index ≥25kg/m²,
* sedentary time ≥7h/day,
* minimum 3 working days on site,
* no known cardiovascular or metabolic pathology, social security affiliation or benefit,
* ability and willingness to give free, written and informed consent.

Exclusion Criteria:

* pregnant or breast-feeding women,
* anti-hypertensive treatment, beta-blockers and anti-diabetics,
* known contraindications to physical activity (articular, cardiac or other),
* exercise-induced asthma,
* lack of motivation of subjects posing problems of compliance and adherence to the exercise program,
* participation in a study in the preceding 3 months, ongoing participation in a clinical trial.

Primary outcomes:
measure: Changes in aerobic fitness
timeFrame: at inclusion, at the end of the 4-weeks program and 1 month following the end of the program
Secondary outcomes:
measure: Adherence of staff in the experimental group by analyzing accelerometric data.
timeFrame: during the 4-weeks program
measure: Intensity of exercise-snacks
timeFrame: during the 4-weeks program
measure: Changes in flow mediated dilation of superficial femoral artery
timeFrame: at inclusion, at the end of the 4-weeks program
measure: Changes in peak shear rate of superficial femoral artery
timeFrame: at inclusion, at the end of the 4-weeks program
measure: Changes in nitrate mediated dilation of superficial femoral artery
timeFrame: at inclusion, at the end of the 4-weeks program
measure: Changes in superficial femoral artery compliance
timeFrame: at inclusion, at the end of the 4-weeks program
measure: Changes in carotid intima-thickness
timeFrame: at inclusion, at the end of the 4-weeks program
measure: Changes in carotid compliance
timeFrame: at inclusion, at the end of the 4-weeks program
measure: Changes in carotid-femoral pulse wave velocity
timeFrame: at inclusion, at the end of the 4-weeks program
measure: Changes in post-occlusive skin perfusion
timeFrame: at inclusion, at the end of the 4-weeks program
measure: Changes in blood pressure
timeFrame: at inclusion, at the end of the 4-weeks program and 1 month following the end of the program
measure: Changes in mean amplitude of glycemic excursions
timeFrame: one week before the beginning of the program and the first week of the program and the 2 lastest weeks of the program
measure: Changes in heart rate
timeFrame: between the beginning and end of the 4-week exercise program and 4 weeks after the program.
measure: Changes in level of habitual physical activity
timeFrame: between the start and end of the 4-week exercise program and 4 weeks after the program
measure: Changes in fat mass
timeFrame: between the start and end of the 4-week exercise program and 4 weeks after the program
measure: Changes in lean mass
timeFrame: between the start and end of the 4-week exercise program and 4 weeks after the program
measure: Change in physical activity behaviour at work of staff
timeFrame: between the start and end of the 4-week exercise program.
measure: Changes in rating of perceived exertion
timeFrame: between the start and end of the 4-week exercise program and 4 weeks after the program
Other outcomes:
Locations:
city: Avignon
country: France
facility: Avignon University
Study officials:
affiliation: Avignon University - LaPEC
name: Agnès VINET
role: PRINCIPAL_INVESTIGATOR
References: