Clinical trial NCT06593535: Evaluation of Astaxanthin Properties on Anti-fatigue
Official title: Short-term Astaxanthin Supplementation Enhances Cycling Performance and Attenuates Exhaustive Exercise-induced Muscle Damage and Oxidative Stress in Young Healthy Adults: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Volunteer
Keywords: Cycling performance
fatigue
ergogenic aids
lipid peroxidation
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
Collaborators: name: National Science and Technology Council
name: China Medical University, China
First posted: 2024-09-19
Enrollment: 10
Sex: MALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Ten young healthy physically active male college students. Participants were crossed over for AST or placebo supplements, which was completed in four days. Between the crossover trials, participants had a one-week washout period to nullify the effects of the supplement
Primary purpose: OTHER

Brief summary: Ten young, healthy, physically active male college students were crossed over for AST or placebo supplements randomized into placebo or AST trials and orally consumed placebo or AST (28 mg/d) supplements for four days. Short-term AST supplementation enhanced endurance performance and effectively reversed cycling challenge-induced muscle damage and lipid peroxidation.

Detailed description: AST is composed of two β-ionone ring systems that are linked by a polyene chain and contain oxygenated keto and hydroxyl moieties, which are responsible for its powerful antioxidant activity. AST has been shown to have numerous health benefits in humans, including improved antioxidant and inflammatory status under different stress conditions. Therefore, this study will explore AST supplement to improve exercise-induced muscle damage and/or physiological anomalies in adults. Ten physically active male adults were randomized into placebo or AST trials and consumed placebo or AST (28 mg/d) supplements orally for 4 days. On day-4, participants performed an exhaustive cycling challenge at 75% V̇O2max, and the time to exhaustion (TTE) was recorded. Blood and gaseous samples were collected before, during, and immediately after cycling to determine changes in muscle damage, inflammation, oxidative stress, and substrate utilization.

Eligibility criteria: Inclusion Criteria:

* Recruit people who are healthy are 20-40 years male and have exercise habits in college students

Exclusion Criteria:

* Have smoking and drinking habits.
* Those who have implanted artificial joints in the past six months and have had recent surgery.
* People who feel unwell due to other reasons during the experiment.
* Take any drugs or Nutrition supplements in the past 3 months.

Primary outcomes:
measure: Time to Exhaustion Exercise
timeFrame: 21 days
measure: Clinical Biochemistry of muscle damage biomarkers and blood glucose
timeFrame: 21 days
measure: Clinical Biochemistry of total antioxidant capacity and lipid peroxidation
timeFrame: 21 days
measure: Clinical Biochemistry of the inflammatory response
timeFrame: 21 days
measure: Assessment of the profile of mood state (POMS)
timeFrame: 21 days
measure: Assessment of the RER, fat oxidation rate and carbohydrate oxidation rate
timeFrame: 21 days
Secondary outcomes:
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: China Medical University
Study officials:
affiliation: China Medical University, China
name: Jung-Piao Tsao
role: STUDY_CHAIR
References: