Clinical trial NCT04082546: Correlates of Left Ventricular Global Longitudinal Strain and Surgical Intervention on Myocardial Bridges
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myocardial Bridge of Coronary Artery
Keywords: Coronary abnormalities
Angina
Global longitudinal strain
Speckle-traking echocardiography
Myocardial ischemia
Lead sponsor: ITAB - Institute for Advanced Biomedical Technologies
Sponsor class: OTHER
Collaborators: name: Azienda Ospedaliero, Universitaria Ospedali Riuniti
First posted: 2019-09-09
Enrollment: 10
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients presenting a muscular myocardial bridge of the left anterior descending coronary artery causing chest discomfort/angina

Brief summary: To examine the changes in left ventricular (LV) global longitudinal strain (GLS), using two-dimensional speckle tracking analysis, after left anterior descending (LAD) unroofing, in myocardial bridges (MBs) refractory to optimal medical therapy (OMT).

Detailed description: The present study is enrolling all the MBs-patients who underwent angina surgical relief or medical treatment at the "Ospedali Riuniti" of Ancona, Italy, and the "University Hospital" of Chieti, Italy. All the participants will be examined utilizing echocardiography before and after the treatment. The two-dimensional speckle-tracking analysis will be performed with an off-line dedicated software from the apical 4-chambers-view. All the unroofing procedures will be performed under cardiopulmonary bypass.

Eligibility criteria: Inclusion Criteria:

* Myocardial bridge of the anterior descending left coronary artery

Exclusion Criteria:

* Poor echocardiographic imaging quality

Primary outcomes:
measure: Improvement of myocardial function and contractility
timeFrame: 1 to 6 month after the procedure/treatment optimizzation
Secondary outcomes:
measure: Angina relief after surgical treatment
timeFrame: 1-month
measure: Improvement in quality of life
timeFrame: 1-month
Other outcomes:
Locations:
city: Ancona
country: Italy
facility: Ospedali Riuniti
Study officials:
affiliation: G. d'Annunzio University
name: Francesco Bianco, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Alegria JR, Herrmann J, Holmes DR Jr, Lerman A, Rihal CS. Myocardial bridging. Eur Heart J. 2005 Jun;26(12):1159-68. doi: 10.1093/eurheartj/ehi203. Epub 2005 Mar 11.
citation: Corban MT, Hung OY, Eshtehardi P, Rasoul-Arzrumly E, McDaniel M, Mekonnen G, Timmins LH, Lutz J, Guyton RA, Samady H. Myocardial bridging: contemporary understanding of pathophysiology with implications for diagnostic and therapeutic strategies. J Am Coll Cardiol. 2014 Jun 10;63(22):2346-2355. doi: 10.1016/j.jacc.2014.01.049. Epub 2014 Feb 26.
citation: Cerit L, Duygu H. Myocardial bridging and sudden death. Int J Cardiol. 2017 Feb 15;229:11. doi: 10.1016/j.ijcard.2016.11.308. Epub 2016 Dec 1. No abstract available.
citation: Zhang M, Yang J, Ma C, Liu M. Longitudinal strain measured by two-dimensional speckle tracking echocardiography to evaluate left ventricular function in patients with myocardial bridging of the left anterior descending coronary artery. Echocardiography. 2019 Jun;36(6):1066-1073. doi: 10.1111/echo.14357. Epub 2019 May 13.
citation: Alessandri N, Dei Giudici A, De Angelis S, Urciuoli F, Garante MC, Di Matteo A. Efficacy of calcium channel blockers in the treatment of the myocardial bridging: a pilot study. Eur Rev Med Pharmacol Sci. 2012 Jun;16(6):829-34.