Clinical trial NCT01045824: Family-based Genetic Long-term Study of Brain Function in Schizophrenia
Official title: The Genetic Study of Longitudinal Brain Function Among Schizophrenic Patients With Family History
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Schizophrenia
Blooddraw
MRI
Keywords: Schizophrenia
DNA
MRI
Lead sponsor: Taichung Veterans General Hospital
Sponsor class: OTHER
First posted: 2010-01-11
Enrollment: 600
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: FAMILY_BASED
Sampling method: PROBABILITY_SAMPLE
Study population: Schizophrenia family

Brief summary: The goal of this research is to find out possible susceptible gene(s) in schizophrenic patients with family history and 5-year period functional changes of brain among the members of family, in order to further analysis factors and their interactions.

Detailed description: Schizophrenia is a serious mental disease, highly family inheritable inclination. By means of traditional psychiatry diagnosis, genetics and long term brain change researches will help to unveil the secret of schizophrenia and other factors. The advantage of comparative gene hybridization is that chromosome copy number alterations can be detected; this technique has been widely applied in many researches, such as cancer, mental retardation screening and autism. As we known, we are the first one use this technique in chromosome abnormality research for family history schizophrenic patient, this study also is the first one to track the relationship of long term brain function alteration and chromosome abnormality in Taiwan.

Eligibility criteria: Inclusion Criteria:

1.Psychiatry doctor diagnosed who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for schizophrenia or schizoaffective disorder, family history, age older than 15 will be recruited for participation in this study. Participants agree and sign informed consent forms will eligible to participate this experiment.

2.10-20c.c blood will be drawn from the participants. 3.Participants need to understand procedures and assays of this experiment. 4.At least one psychiatry doctor interview needed, participants and their family voluntarily join this interview, approximately 30-45min.

Exclusion Criteria:

1. Participant can not understand procedures and assays of this experiment.
2. Participant has another major mental disease other than the inclusion criteria.
3. Participant has material abuse history, it could seriously influence diagnosis.
4. Participant has combination diseases, it could seriously influence diagnosis.
5. Psychopathy or psychosis can not be categorized in defined group.

Other considerations:

1. Participants, age fewer than 20 needs to their deputy guardians (parents) and their own consent altogether.
2. Participants who are inability needs to their deputy guardians (parents) and their own consent altogether.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taichung City
country: Taiwan
facility: Taichung Veterans General Hospital
Study officials:
affiliation: Taichung Veterans General Hospital
name: Tsuo-Hung Lan, MD., PhD.
role: STUDY_DIRECTOR
affiliation: Taichung Veterans General Hospital
name: Tsuo-Hung Lan, MD.,PhD
role: STUDY_DIRECTOR
References: