Clinical trial NCT04631822: Comparing Dexamethasone With Dexmedetomidine as Additives to Bupivacaine in Adductor Canal Block for Knee Arthroscopy.
Official title: Comparative Study Between Dexamethasone, and Dexmedetomidine as Additives to Bupivacaine in Ultrasound Guided Adductor Canal Block in Knee Arthroscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain, Postoperative
Keywords: adductor canal regional block
anaesthesia for knee arthroscopic surgeries
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-11-17
Enrollment: 135
Sex: ALL
Minimum age (years): 19
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: a comparison shall be conducted between dexamethasone accompanied by bupivacaine, on one hand, and dexmedetomedine accompanied by bupivacaine on the other hand and a control group for pain-free knee arthroscopic surgeries.

Detailed description: Arthroscopic knee surgery can cause significant postoperative pain to the degree that can potentially delay timely discharge from the ambulatory surgical setting. Analgesia after knee surgery can be provided by multiple, non-systemic, non-opioid-based methods, including local anesthetic infiltration, peripheral nerve blockade, neuraxial procedures, and intra-articular injections. The femoral nerve block has been shown to be superior to traditional intra-articular injection of local anesthetics in some knee surgeries, but motor blockade of the quadriceps muscle, with the potential risk for falls, limits the value of femoral blocks for less invasive ambulatory surgery. Orthopedic surgery is increasingly being performed on an ambulatory basis, where perioperative analgesia can improve timely discharge in the outpatient setting.

Eligibility criteria: Inclusion Criteria: -

* Adult patients of aged more than 18 years old ASA "American Society of Anaesthesia"
* physical status I or II under-going any unilateral knee arthroscopy. Exclusion Criteria: -
* patient refusal.
* Pre-existing pain ; postoperative pain similar to preoperative pain
* Known contraindications to peripheral nerve block, including local skin infections, bleeding diathesis, and coagulopathy.
* Allergies to local anesthetics, dexmedetomidine, or any component of multimodal analgesia.

Primary outcomes:
measure: Dynamic Visual Analogue Scale score
timeFrame: month 1 postoperative
Secondary outcomes:
measure: Dynamic Visual Analogue Scale score
timeFrame: month 3 postoperative
measure: 24 hours opioid analgesia consumed
timeFrame: 24 hours postoperative
measure: Visual Analogue Scale score
timeFrame: 24 hours postoperative
measure: month 3 opioid analgesia
timeFrame: month 3 postoperative
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Rasha Hamed
Study officials:
affiliation: Professor of Anesthesia and Intensive care unit, faculty of medicine, Assiut University
name: Hamdy A Yousef, MD
role: STUDY_CHAIR
affiliation: Lecturer of Anesthesia and Intensive care unit, faculty of medicine, Assiut University
name: yara A yousef, Lecturer
role: STUDY_DIRECTOR
affiliation: aisstant professor of anesthesia and ICU
name: rasha hamed, MD
role: PRINCIPAL_INVESTIGATOR
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