Clinical trial NCT05315635: Substance Use and Eating Disorders : Food Craving and Addiction Transfer
Official title: Substance Use and Eating Disorders : Food Craving and Addiction Transfer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Substance Use Disorders
Eating Disorders
Keywords: Substance Use Disorders
Eating Disorders
Food craving
Addiction transfer
Addiction
Craving
Lead sponsor: Centre Hospitalier Charles Perrens, Bordeaux
Sponsor class: OTHER_GOV
First posted: 2022-04-07
Enrollment: 294
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Diagnostic and Statistical Manual (DSM)-5 diagnostic criteria for substance use disorder/behavioral addiction (gambling) or DSM-5 diagnostic criteria for eating disorders (Anorexia nervosa, Bulimia nervosa, Hyperphagia access)

Brief summary: Substance Use Disorder (SUD) and Eating Disorders (ED) are severe and persistent disturbances that are associated with significant harm. These two disorders have many clinical similarities, including craving and behavioral loss of control. Recently, craving for food has been described in newly abstinent patients with SUD. the aim of the study is to verify the hypothesis of addiction transfer based on common neurobiological mechanisms between substance craving and food craving, that postulates that food craving would correspond to an attempt to regulate substance craving (or vice versa).

Detailed description: The knowledge of existence of common addictive, neurobiological and clinical processes between substance use disorders and eating disorders has been a promising approach for a better understanding of the factors involved in the emergence and maintenance of these disorders. Several studies have shown that increased palatable food with high sugar or fat content causes brain neurochemistry changes similar to those observed after use of addictive drugs. Clinical and behavioral similarities concerning craving, loss of control and use as a coping strategy have also been highlighted. Craving is considered as a clinical marker of addiction and a potent predictor of relapse vulnerability. In substance addiction, the link between craving, use and relapse has been previously demonstrated in experimental and daily life studies. The main objective of this study is to examine the hypothesis of addiction transfer between Substance Use Disorders and Eating Disorders, according to which food craving for palatable foods would correspond to an attempt to regulate substance craving or vice versa. One assumption is that food intake could be used to alleviate craving for substances in patients hospitalized for substance use disorder. The secondary objective is to explore psychopathological, addictive, and medical similarities between substance use disorder and eating disorder participants. Included patients (group 1: substance use disorder participants and group 2: eating disorder) will be asked to answer different self-questionnaires, as well as a clinical psychiatric (MINI) and cognitive (MoCA) assessment.

Eligibility criteria: Inclusion Criteria:

* DSM-5 diagnostic criteria for substance use disorder/behavioral addiction (gambling) or an eating disorder (Anorexia nervosa, Bulimia nervosa or Hyperphagia access).
* Begin treatment in addiction complex care unit, located in inter-hospital unit Charles Perrens Hospital and Bordeaux University Hospital
* Non-opposition formulated

Exclusion Criteria:

* Severely impaired physical and/or mental health that, according to the investigator, may affect the participant's compliance with the study and understanding of assessment tools
* Trouble in understanding/writing French
* Hospitalization for less than 3-weeks for patients with substance use disorders or behavioral addiction (gambling)
* Individuals participating in another study that includes an ongoing exclusion period.
* Be under guardianship
* Pregnant and/or lactating woman

Primary outcomes:
measure: Craving for substance
timeFrame: At the inclusion
measure: Craving for substance
timeFrame: At week-3
measure: Craving for food
timeFrame: At the inclusion
Secondary outcomes:
measure: Identify common determinants of food craving in patients suffering from ED
timeFrame: At inclusion
measure: Identify common determinants of food craving in patients suffering from ED & SUD - Addictive characteristics :
timeFrame: At inclusion
measure: Identify common determinants of food craving in patients suffering from ED & SUD - Emotional characteristics
timeFrame: At inclusion
measure: Identify common determinants of food craving in patients suffering from ED & SUD - Psychopathological and cognitive characteristics
timeFrame: At inclusion
measure: Identify Medical characteristics : of food craving in patients suffering from ED - Medical characteristics :
timeFrame: At inclusion
measure: Identify Medical characteristics : of food craving in patients suffering from SUD
timeFrame: At inclusion and at week-3
measure: Identify cognitive characteristics of food craving in patients suffering from ED
timeFrame: At inclusion
measure: Identify cognitive characteristics of food craving in patients suffering from SUD
timeFrame: At inclusion and at week-3
measure: Identify addictive characteristics of substances craving in patients suffering from SUD
timeFrame: At week-3 At inclusion and at week-3
measure: Identify emotional characteristics of substances craving in patients suffering from SUD
timeFrame: At week-3
measure: Identify psychopathological characteristics of substances craving in patients suffering from SUD
timeFrame: At week-3
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: Centre Hospitalier Universitaire de Bordeaux
state: Gironde
Study officials:
affiliation: Physician
name: Mélina FATSEAS, Prof, MD
role: STUDY_DIRECTOR
References:
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citation: Bydlowski S, Corcos M, Jeammet P, Paterniti S, Berthoz S, Laurier C, Chambry J, Consoli SM. Emotion-processing deficits in eating disorders. Int J Eat Disord. 2005 May;37(4):321-9. doi: 10.1002/eat.20132.
citation: Calero-Elvira A, Krug I, Davis K, Lopez C, Fernandez-Aranda F, Treasure J. Meta-analysis on drugs in people with eating disorders. Eur Eat Disord Rev. 2009 Jul;17(4):243-59. doi: 10.1002/erv.936.
citation: Canan F, Karaca S, Sogucak S, Gecici O, Kuloglu M. Eating disorders and food addiction in men with heroin use disorder: a controlled study. Eat Weight Disord. 2017 Jun;22(2):249-257. doi: 10.1007/s40519-017-0378-9. Epub 2017 Apr 22.