Clinical trial NCT04985968: The Efficacy and Safety of Cobitolimod in Participants With Moderate to Severe Active Left-Sided Ulcerative Colitis
Official title: A Randomised Double-Blind Placebo-Controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of Cobitolimod as an Induction and Maintenance Therapy in Participants With Moderate to Severe Active Left-Sided Ulcerative Colitis
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Ulcerative Colitis
Keywords: Colitis, Ulcerative
Gastrointestinal Disease
Inflammatory Bowel Diseases
Glucocorticosteroids
Anti-Inflammatory Agents
Therapeutic uses
Cobitolimod
Toll like receptor 9 agonist
TLR9 agonist
Kappaproct
IDX0150
DIMS0150
Lead sponsor: InDex Pharmaceuticals
Sponsor class: INDUSTRY
First posted: 2021-08-02
Enrollment: 171
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to evaluate the efficacy of cobitolimod treatment compared to placebo in inducing clinical remission, in participants with moderate to severe active left-sided UC and to evaluate the efficacy of cobitolimod maintenance treatment compared to placebo in inducing or maintaining clinical remission at week 52, in participants with clinical response at week 6 after induction treatment with cobitolimod.

Detailed description: This phase III study protocol includes an induction study for 6 weeks and a maintenance study for an additional 45 weeks.

In the induction study there will be an initial phase to explore the best dose, between cobitolimod 250 mg and cobitolimod 500 mg using adaptive design.

Eligibility criteria: Inclusion Criteria Induction:

* Male or female ≥ 18 years of age.
* Established diagnosis of UC.
* Moderate to severe active left-sided UC assessed by central reading.
* Have inadequate response, loss of response or be intolerant of at least one of the following treatments: Oral GCS, AZA/6-MP, Biologics, JAK-inhibitors, or other approved advanced therapies for UC.
* Allowed to receive a therapeutic dose of the following UC drugs during the study: Oral GCS therapy (≤20 mg prednisone or equivalent/day) , Oral 5-ASA/SP compounds, AZA/6-MP.
* Ability to understand the treatment, willingness to comply with all study requirements, and ability to provide informed consent.

Exclusion Criteria Induction:

* Suspicion of differential diagnosis.
* Acute fulminant UC and/or signs of systemic toxicity.
* UC limited to the rectum or extending beyond the splenic flexure.
* Have failed treatment with more than three advanced therapies of two different therapeutic classes.
* Have had surgery for treatment of UC.
* History of malignancy, unless treated with no relapse of the disease and ≥ 5 years since last treatment (cured).
* History or presence of any clinically significant disorder.
* Concomitant treatment with cyclosporine, methotrexate, tacrolimus, or advanced therapies or similar immunosuppressants and immunomodulators.
* Treatment with rectal GCS, 5-ASA/SP or tacrolimus.
* Long-term treatment (\>14 days) with antibiotics or NSAIDs .
* Serious known active infection including history of latent or active tuberculosis.
* Gastrointestinal infections including positive Clostridium difficile stool assay.
* Females who are lactating or have a positive serum pregnancy test.
* Women of childbearing potential not using highly effective contraceptive methods.
* Concurrent participation in another clinical study.
* Previous exposure to cobitolimod.

Inclusion Criteria Maintenance:

* Participants are eligible to be included in the maintenance study if they have achieved clinical response at week 6 and have adhered to the protocol procedures of the induction study.

Exclusion Criteria Maintenance:

* Participants will not be eligible for the maintenance study if they are not willing to comply with all further study requirements.

Primary outcomes:
measure: Induction - Proportion of participants with clinical remission.
timeFrame: Week 6
measure: Maintenance - Proportion of participants with clinical remission.
timeFrame: Week 52
Secondary outcomes:
measure: Induction - Proportion of participants with endoscopic improvement.
timeFrame: Week 6
measure: Induction - Proportion of participants with symptomatic remission.
timeFrame: Week 6
measure: Induction - Proportion of participants with clinical response.
timeFrame: Week 6
measure: Induction - Proportion of participants with normalisation of stool frequency.
timeFrame: Week 6
measure: Induction - Proportion of participants with absence of rectal bleeding.
timeFrame: Week 6
measure: Induction - Mean stool frequency.
timeFrame: Week 6
measure: Induction - Proportion of participants with histologic improvement.
timeFrame: Week 6
measure: Induction - Proportion of participants with histologic remission.
timeFrame: Week 6
measure: Induction - Proportion of participants with mucosal healing.
timeFrame: Week 6
measure: Induction - Mean ln-transformed faecal calprotectin.
timeFrame: Week 6
measure: Induction - Mean 3-component and 4-component Mayo scores.
timeFrame: Week 6
measure: Induction - Mean IBDQ total score.
timeFrame: Week 6
measure: Induction - Proportion of participants with an improvement in IBDQ total score.
timeFrame: Week 6
measure: Maintenance - Proportion of participants with endoscopic improvement.
timeFrame: Week 52
measure: Maintenance - Proportion of participants with clinical remission and steroid-free.
timeFrame: Week 52
measure: Maintenance - Proportion of participants with clinical remission among those who achieved clinical remission
timeFrame: Week 52
measure: Maintenance - Proportion of participants with symptomatic remission.
timeFrame: Week 52
measure: Maintenance - Proportion of participants with histologic improvement.
timeFrame: Week 52
measure: Maintenance - Proportion of participants with histologic remission.
timeFrame: Week 52
measure: Maintenance - Proportion of participants with mucosal healing.
timeFrame: Week 52
measure: Maintenance - Proportion of participants with clinical response.
timeFrame: Week 52
measure: Maintenance - Proportion of participants with absence of rectal bleeding.
timeFrame: Week 52
measure: Maintenance - Proportion of participants with normalisation of stool frequency.
timeFrame: Week 52
measure: Maintenance - Mean stool frequency.
timeFrame: Week 52
measure: Maintenance - Mean ln-transformed faecal calprotectin.
timeFrame: Week 52
measure: Maintenance - Mean 3-component and 4-component Mayo scores.
timeFrame: Week 52
measure: Maintenance - Mean IBDQ total score.
timeFrame: Week 52
measure: Maintenance - Proportion of participants with an improvement in IBDQ total score.
timeFrame: Week 52
Other outcomes:
Locations:
city: Granada Hills
country: United States
facility: Amicis Research Center
state: California
city: Mission Viejo
country: United States
facility: Allameh Medical Corporation
state: California
city: Rancho Cucamonga
country: United States
facility: Prospective Research Innovations Inc.
state: California
city: Tarzana
country: United States
facility: Valiance Clinical Research
state: California
city: Boynton Beach
country: United States
facility: RecioMed Clinical Research Network, Inc.
state: Florida
city: Doral
country: United States
facility: MB & V Medical Research
state: Florida
city: Miami
country: United States
facility: A+ Research, Inc.
state: Florida
city: Miami
country: United States
facility: SouthCoast Research Center, Inc
state: Florida
city: Miami
country: United States
facility: I.V.A.M. Clinical & Investigational Center LLC
state: Florida
city: Miami
country: United States
facility: D&H National Research Centers, Inc.
state: Florida
city: Miami
country: United States
facility: Medical Professionals Clinical Research Center
state: Florida
city: Naples
country: United States
facility: Gastroenterology Group Of Naples
state: Florida
city: Tampa
country: United States
facility: Alliance Clinical Research - Gastroenterology
state: Florida
city: Topeka
country: United States
facility: Cotton O'Neil Clinical Research Center
state: Kansas
city: Troy
country: United States
facility: Clinical Research Institute of Michigan
state: Michigan
city: New York
country: United States
facility: Lenox Hill Hospital
state: New York
city: Charlotte
country: United States
facility: Carolina Digestive Health Associates, PA
state: North Carolina
city: Greenville
country: United States
facility: Carolina Research
state: North Carolina
city: High Point
country: United States
facility: Peters Medical Research
state: North Carolina
city: Beavercreek
country: United States
facility: Dayton Gastroenterology
state: Ohio
city: Carrollton
country: United States
facility: Digestive Health Associates of Texas, PA
state: Texas
city: Houston
country: United States
facility: Clinical Research Solution: Digestive Health Associates
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine - Gastroeneterology
state: Texas
city: Fairfax
country: United States
facility: Gastroenterology Associates of Northern Virginia
state: Virginia
city: Milwaukee
country: United States
facility: Wisconsin Center For Advanced Research
state: Wisconsin
city: Clayton
country: Australia
facility: Monash Health
city: Fitzroy
country: Australia
facility: St Vincent's Hospital Melbourne
city: Melbourne
country: Australia
facility: The Alfred Hospital
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
city: South Brisbane
country: Australia
facility: Mater Health Services
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital
city: Innsbruck
country: Austria
facility: MedUn Innsbruck
city: Klagenfurt
country: Austria
facility: LKH Klagenfurt
city: Salzburg
country: Austria
facility: Universitätsklinikum Salzburg
city: Wien
country: Austria
facility: Akh Wien
city: Antwerpen
country: Belgium
facility: UZ Antwerpen
city: Bonheiden
country: Belgium
facility: Imelda Ziekenhuis
city: Brussels
country: Belgium
facility: Erasme University Hospital
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent
city: Kortrijk
country: Belgium
facility: AZ Groeninge - Campus Kennedylaan
city: Roeselare
country: Belgium
facility: AZ Delta
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska - Gastroenterology
city: Foca
country: Bosnia and Herzegovina
facility: The University Hospital Foca
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center University of Sarajevo - Gastroenterology
city: Sarajevo
country: Bosnia and Herzegovina
facility: General Hospital "Prim.dr.Abdulah Nakas"
city: Sarajevo
country: Bosnia and Herzegovina
facility: Polyclinic Dr. Al-Tawil
city: Tesanj
country: Bosnia and Herzegovina
facility: Opca Bolnica Tesanj
city: Tuzla
country: Bosnia and Herzegovina
facility: Plava Medical Group
city: Zenica
country: Bosnia and Herzegovina
facility: Cantonal Hospital Zenica
city: Goiania
country: Brazil
facility: Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre - Centro de Pesquisa Clinica
city: Rio De Janeiro
country: Brazil
facility: Ufrj - Hospital Universitario Clementino Fraga Filho
city: Santo Andre
country: Brazil
facility: Praxis Pesquisa Medica
city: Sao Jose do Rio Preto
country: Brazil
facility: Kaiser Clinica
city: São Bernardo do Campo
country: Brazil
facility: CEMEC - Centro Multidisciplinar de Estudos Clinicos
city: Hamilton
country: Canada
facility: MUMC - Hamilton Health Sciences
city: Montréal
country: Canada
facility: Installation Hospital Maisonneuve-Rosemont
city: Saskatoon
country: Canada
facility: Royal University Hospital
city: Bjelovar
country: Croatia
facility: Opca bolnica Bjelovar
city: Osijek
country: Croatia
facility: Clinical Hospital Osijek
city: Pula
country: Croatia
facility: Opca bolnica Pula
city: Zadar
country: Croatia
facility: Zadar General Hospital
city: Zagreb
country: Croatia
facility: Poliklinika Solmed
city: Zagreb
country: Croatia
facility: University Hospital Centre Zagreb
city: Aalborg
country: Denmark
facility: Aalborg University Hospital
city: Aarhus
country: Denmark
facility: Aarhus University Hospital
city: Herlev
country: Denmark
facility: Herlev Hospital
city: Hillerød
country: Denmark
facility: Hillerod Hospital
city: Vejle
country: Denmark
facility: Lillebælt Hospital Vejle
city: Lille
country: France
facility: CHRU de Lille - Hôpital Claude Huriez
city: Montpellier
country: France
facility: CHRU Montpellier-Hopital Saint Eloi - Hepato-gastro-enterologie
city: Nancy
country: France
facility: CHU de Nancy Brabois
city: Nice
country: France
facility: CHU de Nice - Hôpital de l'Archet II - Gastro-Entérologie, Hépatologie
city: Paris Cedex 12
country: France
facility: Hopital Saint Antoine
city: Paris
country: France
facility: Hopital Bichat - Gastroenterology
city: Pierre Benite Cedex
country: France
facility: Centre Hospitalier Lyon Sud
city: Poitiers
country: France
facility: Centre Hospitalier Universitaire de Poitiers
city: Saint-Étienne
country: France
facility: CHU de Saint Etienne, Hôpital Nord - Service de Gastroentérologie
city: Salouel
country: France
facility: CHU Amiens - Hopital Sud - Service Hepato-Gastroenterolog
city: Toulouse
country: France
facility: Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
city: Batumi
country: Georgia
facility: JSC " Evex Hospitals"
city: Tiflis
country: Georgia
facility: LTD Israel-Georgian Medical Research Clinic Helsicore
city: Augsburg
country: Germany
facility: Universitätsklinikum Augsburg
city: Berlin
country: Germany
facility: Charité - Universitätsmedizin Berlin KöR
city: Cologne
country: Germany
facility: University Hospital Cologne AöR
city: Duisburg
country: Germany
facility: MVZ Sanaklinikum Duisburg
city: Erlangen
country: Germany
facility: Universitätsklinikum Erlangen
city: Frankfurt am main
country: Germany
facility: Agaplesion Markus Krankenhaus
city: Frankfurt am Main
country: Germany
facility: Klinikum der Johann Wolfgang Goethe-Universität - Medizinische Klinik I
city: Freiburg
country: Germany
facility: Universitätsklinikum Freiburg
city: Halle
country: Germany
facility: Uniklinik Halle (Saale)
city: Heidelberg
country: Germany
facility: Gastroenterology Outpatient Clinic Prof. Dr. med. Ehehalt
city: Kiel
country: Germany
facility: University Hospital Schleswig-Holstein
city: Mannheim
country: Germany
facility: Universitätsmedizin Mannheim
city: Nürtingen
country: Germany
facility: Medius Klinik Nürtingen
city: Rostock
country: Germany
facility: Universitätsklinikum Rostock
city: Ulm
country: Germany
facility: Universitätsklinikum Ulm
city: Weyhe
country: Germany
facility: Internistische Praxis Weyhe
city: Budapest
country: Hungary
facility: Clinexpert Egészségügyi Szolgáltató És Kereskedelmi Kft.
city: Budapest
country: Hungary
facility: Pannónia Magánorvosi Centrum Kft
city: Budapest
country: Hungary
facility: Semmelweis Egyetem Altalanos Orvostudomanyi Kar Sebeszeti, Transzplantacios es Gasztroenterologiai Klinika
city: Budapest
country: Hungary
facility: Semmelweis Egyetem Altalanos Orvostudomanyi Kar
city: Szeged
country: Hungary
facility: SzTE Szt-Gy A Orvostud Kar Bel Klin
city: Ashkelon
country: Israel
facility: The Barzilai Medical Center
city: H̱olon
country: Israel
facility: The Edith Wolfson Medical Center
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization, Hadassah Medical Center, Ein-
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
city: Nahariya
country: Israel
facility: Galilee Medical Center (Western Galilee Hospital)
city: Rehovot
country: Israel
facility: Kaplan Medical Center
city: Bergamo
country: Italy
facility: ASST Papa Giovanni XXIII - Cardiologia - Bergamo
city: Cagliari
country: Italy
facility: AO Brotzu
city: Firenze
country: Italy
facility: Universita degli Studi di Firenze - Azienda Ospedaliero - Un
city: Milan
country: Italy
facility: IRCCS Ospedale San Raffaele
city: Monza
country: Italy
facility: Azienda Ospedaliera San Gerardo
city: Padova
country: Italy
facility: AOU di Padova
city: Roma
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Tor Vergata (P
city: Roma
country: Italy
facility: Policlinico Universitario Agostino Gemelli
city: Rom
country: Italy
facility: Policlinico Universitario Campus Biomedico
city: Torino
country: Italy
facility: A.O. Ordine Mauriziano Di Torino
city: Udine
country: Italy
facility: AOU S. Maria della Misericordia
city: Varese
country: Italy
facility: Universita degli Studi dell'Insubria - Ospedale di Circolo e
city: Busan
country: Korea, Republic of
facility: Inje University Haeundae Paik Hospital
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Hospital
city: Guri-Si
country: Korea, Republic of
facility: Hanyang University Guri Hospital
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Soeul
country: Korea, Republic of
facility: Kyung Hee University Hospital - Internal Medicine
city: Soeul
country: Korea, Republic of
facility: Kyung Hee University Hospital
city: Suwon-Si
country: Korea, Republic of
facility: The Catholic University of Korea, St. Vincent's Hospital
city: Wŏnju
country: Korea, Republic of
facility: Yonsei University, Wonju Severance Christian Hospital
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kauno Klinikos
city: Klaipeda
country: Lithuania
facility: Klaipeda Seamen's Hospital
city: Klaipeda
country: Lithuania
facility: Republic Klaipeda Hospital
city: Panevezys
country: Lithuania
facility: Panevezio ligonine
city: Vilnius
country: Lithuania
facility: Vilniaus Universiteto ligonines Santariskiu Klinikos
city: Durango
country: Mexico
facility: Instituto de Investigaciones Aplicadas a la Neurociencia A.C.
city: Merida
country: Mexico
facility: Medical Care and Research S. A. de C. V
city: Mexico City
country: Mexico
facility: Clinicos Asociados Bocm, S.C.
city: Monterrey
country: Mexico
facility: Centro Regiomontano de Estudios Clinicos Roma SC
city: Tlalnepantla
country: Mexico
facility: Clinical Research Institute S.C.
city: Nijmegen
country: Netherlands
facility: Radboud University Medical Center
city: Lørenskog
country: Norway
facility: Akershus Universitetssykehus
city: Tromsø
country: Norway
facility: Universitetssykehuset Nord-Norge Tromsø, Gastrolab, Medisinsk poliklinikk, B8
city: Tønsberg
country: Norway
facility: Vestfold Hjertesenter As
city: Ålesund
country: Norway
facility: Ålesund Hospital, Møre & Romsdal Hospital trust, Dept. of Medicine, div of Gastroenterology and the Clinical research unit HMR
city: Grudziadz
country: Poland
facility: MPS - MED sp. z o.o.
city: Knurow
country: Poland
facility: MZ Badania Slowik Zymla Spolka jawna
city: Krakow
country: Poland
facility: Centrum Medyczne PROMED
city: Krakow
country: Poland
facility: Krakowskie Centrum Medyczne Sp. z o.o.
city: Kraków
country: Poland
facility: Centrum Medyczne Plejady
city: Lodz
country: Poland
facility: Szpital Zakonu Bonifratrow Sw. Jana Bozego w Lodzi
city: Malbork
country: Poland
facility: Klinika Badawcza Centrum Badawcze Panaceum Agnieszka Brzezicka, Magdalena Lenkiewicz Sp. z o.o.
city: Opole
country: Poland
facility: Twoja Przychodnia - Opolskie Centrum Medyczne
city: Oswiecim
country: Poland
facility: Medicome Sp. z o.o.
city: Poznan
country: Poland
facility: Szpital Kliniczny im. Heliodora Swiecickiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu
city: Skierniewice
country: Poland
facility: ETG Skierniewice
city: Staszow
country: Poland
facility: KO-MED Centra Kliniczne Staszow
city: Szczecin
country: Poland
facility: Twoja Przychodnia - SCM
city: Torun
country: Poland
facility: GASTROMED Kopoń, Zmudziński i Wspólnicy spółka jawna, Specjalistyczne Centrum Gastrologii i Endoskopii, Specjalistyczne Gabinety Lekarskie
city: Warsaw
country: Poland
facility: Centrum Zdrowia Matki, Dziecka i Mlodziezy
city: Warszawa
country: Poland
facility: Bodyclinic sp. z o.o. sp.k.
city: Warszawa
country: Poland
facility: Centralny Szpital Kliniczny MSWiA w Warszawie
city: Wroclaw
country: Poland
facility: PlanetMed
city: Zamosc
country: Poland
facility: ETG Zamosc
city: Amadora
country: Portugal
facility: Hospital Prof. Doutor Fernando Fonseca (HFF) (Hospital Amadora Sintra)
city: Braga
country: Portugal
facility: Hospital de Braga
city: Loures
country: Portugal
facility: Hospital Beatriz Angelo (HBA)
city: Santa Maria da Feira
country: Portugal
facility: Centro Hospitalar de Entre o Douro e Vouga (CHEDV)- Hospital São Sebastião
city: Bucharest
country: Romania
facility: Spitalul Clinic Colentina
city: Bucuresti
country: Romania
facility: Sana Monitoring
city: Cluj-Napoca
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Cluj-Napoca
city: Iasi
country: Romania
facility: Spitalul Clinic Judetean de Urgenta "Sf. Spiridon" Iasi
city: Timişoara
country: Romania
facility: Cabinet Particular Policlinic Algomed
city: Târgu Mureș
country: Romania
facility: Spitalul Clinic Judetean Mures
city: Belgrade
country: Serbia
facility: Clinic Center of Serbia
city: Belgrade
country: Serbia
facility: Clinical Hospital Center "Dr. Dragisa Misovic"
city: Belgrade
country: Serbia
facility: Euromedik Hospital
city: Belgrad
country: Serbia
facility: Zvezdara University Medical Center
city: Kragujevac
country: Serbia
facility: Clinical Center Kragujevac - Center for Gastroenterohepatology
city: Zrenjanin
country: Serbia
facility: General Hospital Dr Djordje Joanovic
city: Zrenjanin
country: Serbia
facility: General hospital Zrenjanin
city: Banska Bystrica
country: Slovakia
facility: FNsP F.D.R. Banska Bystrica
city: Bratislava
country: Slovakia
facility: CLINIQ s.r.o.
city: Košice
country: Slovakia
facility: ENDOMED s.r.o.
city: Nove Zamky
country: Slovakia
facility: GASTROMEDIC, s.r.o.
city: Sahy
country: Slovakia
facility: Accout Center s.r.o.
city: Stockholm
country: Sweden
facility: Karolinska Universitetssjukhuset - Gastroenterology
city: Uppsala
country: Sweden
facility: Uppsala University Hospital, Akademiska
city: Örebro
country: Sweden
facility: Örebro Univ. Hospital
city: Ankara
country: Turkey
facility: Hacettepe University Medical Faculty - Hematology
city: Istanbul
country: Turkey
facility: Istanbul University Medical Faculty
city: Mersin
country: Turkey
facility: Mersin Universtiy Medical Faculty
city: Bury
country: United Kingdom
facility: Northern Care Alliance NHS Foundation Trust-Fairfield General Hospital - Gastroenterology
city: Coventry
country: United Kingdom
facility: Accellacare Warwickshire Quality Research Site
city: Darlington
country: United Kingdom
facility: County Durham and Darlington NHS Foundation Trust (CDDFT) - Darlington Memorial Hospital
city: Glasgow
country: United Kingdom
facility: Glasgow Royal Infirmary
city: Harrow
country: United Kingdom
facility: North West London Hospitals NHS Trust
city: London
country: United Kingdom
facility: Central Middlesex Hospital
city: London
country: United Kingdom
facility: Kings College Hospital
city: Northwood
country: United Kingdom
facility: Accellacare North London
city: Orpington
country: United Kingdom
facility: Accellacare Limited/Accellacare of South London
city: Reading
country: United Kingdom
facility: Royal Berkshire Hospital
Study officials:
affiliation: Friedrich-Alexander University Erlangen-Nuremberg
name: Raja Atreya, Professor
role: PRINCIPAL_INVESTIGATOR
References: