louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03757663: UV Dosimetry Feedback in NMSC Patients
Official title: UV Dosimetry Feedback in Non-Melanoma Skin Cancer Patients
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Non-Melanoma Skin Cancer
Keywords: UV Dosimetry
UV Exposure
Behavioral
Social Cognitive Theory
Self-Regulation
Self-Efficacy
Lead sponsor: University of Colorado, Denver
Sponsor class: OTHER
First posted: 2018-11-29
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Each participant will self-report skin protective behaviors and attitudes before wearing a UV dosimeter for 3 weeks. After the wear period, the study team provides feedback based on UV exposure. The participant will then wear the device again for 3 weeks.
Primary purpose: PREVENTION

Brief summary: This study aims to characterize UV exposures among NMSC patients (those with a history of skin cancer) and to pilot an innovative behavioral intervention to decrease modifiable UV exposures. It will use UV dosimeters to objectively measure UV exposure and provide time and activity specific UV data on an individual level. These data will be used to develop a targeted and personalized behavioral feedback plan with counseling aimed at effective sun exposure behavior change

Detailed description: The study will focus on helping to prevent NMSC and its associated morbidity through learning when patients are unintentionally exposed to extreme UV radiation. It will then help to create manageable and realistic behavioral interventions to reduce exposure, while also educating patients of the dangers of abundant sun exposure.

Eligibility criteria: Inclusion Criteria:

* Patients between ages 18 and 50.
* Must be diagnosed with non-melanoma skin cancer.

Exclusion Criteria:

* Patients, who at the discretion of the clinician, are too ill or sick.
* Non-English speaking patients.

Primary outcomes:
measure: Identify Discrepancies of Self-Reported Sun Exposure and Actual Sun Exposure
timeFrame: Start of study to end of study, up to 3 months
measure: Identify Discrepancies of Self-Reported Sun Exposure and Actual Sun Exposure
timeFrame: Start of study to end of study, up to 3 months
Secondary outcomes:
measure: Behavioral Intervention and immediate follow-up
timeFrame: Start of study to end of study, up to 3 months
measure: Long Term Follow Up - longitudinal change in sun exposure based on dosimetry
timeFrame: Start of study to end of study, up to 3 months
Other outcomes:
Locations:
city: Aurora
country: United States
facility: University of Colorado
state: Colorado
Study officials:
affiliation: University of Colorado, Denver
name: Myles Cockburn, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05169463: NETTUNIT - Italy-Tunisia Cross-border Environmental network_1
Official title: NETTUNIT - Italy-Tunisia Cross-border Environmental network_1
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Respiratory Disease
Cardiovascular Diseases
Lead sponsor: Istituto per la Ricerca e l'Innovazione Biomedica
Sponsor class: OTHER
First posted: 2021-12-27
Enrollment: 10000
Sex: ALL
Minimum age (years): 0
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All emergency room visits for respiratory or cardiovascular problems at the hospital of Gela (Italy) and Niscemi (Italy), from 2010 to 2019.

Brief summary: Retrospective, case-crossover study aiming to use environmental pollutant data for assessing the associated risk of visiting the emergency room (ER) for respiratory or cardiovascular problems in the territory of the Caltanissetta Provincial Health Authority (Italy). All the ER visits for respiratory and/or cardiovascular disorders in the hospital of Gela (Italy) and Niscemi (Italy) from 2010 to 2019 will be considered.


Eligibility criteria: Inclusion Criteria:

* All emergency room visits for respiratory or cardiovascular problems at the hospital of Gela (Italy) and Niscemi (Italy), from 2010 to 2019.

Exclusion Criteria:

* Emergency room visits for other diseases.

Primary outcomes:
measure: Occurrence of emergency room visit for respiratory diseases (binary outcome)
timeFrame: From year 2010 to year 2019
measure: Occurrence of emergency room visit for cardiovascular diseases (binary outcome)
timeFrame: From year 2010 to year 2019
Secondary outcomes:
Other outcomes:
Locations:
city: Palermo
country: Italy
facility: Institute for Biomedical Research and Innovation (IRIB) - National Research Council (CNR)
Study officials:
References:
Clinical trial NCT00867763: In Vitro Maturation With in Vitro Fertilization (IVF) Compared to Mild in Vitro Fertilization
Official title: Clinical Research Study on in Vitro Maturation With IVF Compared to Mild Stimulation IVF
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: NA
Conditions: Infertility
Keywords: Polycystic ovaries,
Tubal occlusion
Unexplained infertility
Low ovarian reserve
Male factor infertility
Lead sponsor: Batzofin Fertility Services
Sponsor class: OTHER
First posted: 2009-03-24
Enrollment: 1440
Sex: FEMALE
Minimum age (years): 21
Maximum age (years): 41
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Methods of infertility treatment may involve in vitro fertilization or IVF. Though effective, IVF is complex and expensive. Methods using no gonadotropin hormone stimulation of the ovaries are being compared to mild stimulation doses. The goal of the research is to determine which of these if more suitable as a low cost approach for varying individual patients.

Detailed description: Low cost environment is utilized, but fees are charged.

Eligibility criteria: Inclusion Criteria:

* Under age 42 female, normal uterine cavity, BMI 18-34kg/m2,

Exclusion Criteria:

* Donor eggs, donor sperm, myoma over 5 cm
* Current hydrosalpinx, abnormal uterine cavity.

Primary outcomes:
measure: Cost effectiveness
timeFrame: two years
Secondary outcomes:
measure: Ongoing pregnancy rates per cycle
timeFrame: 3 months
Other outcomes:
Locations:
city: New York
country: United States
facility: Batzofin Fertilty Services
state: New York
city: NY
country: United States
facility: BFS
state: New York
Study officials:
affiliation: Batzofin Fertility Services
name: Joe B Massey, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Son WY, Chung JT, Herrero B, Dean N, Demirtas E, Holzer H, Elizur S, Chian RC, Tan SL. Selection of the optimal day for oocyte retrieval based on the diameter of the dominant follicle in hCG-primed in vitro maturation cycles. Hum Reprod. 2008 Dec;23(12):2680-5. doi: 10.1093/humrep/den332. Epub 2008 Sep 4.
citation: Son WY, Chung JT, Demirtas E, Holzer H, Sylvestre C, Buckett W, Chian RC, Tan SL. Comparison of in-vitro maturation cycles with and without in-vivo matured oocytes retrieved. Reprod Biomed Online. 2008 Jul;17(1):59-67. doi: 10.1016/s1472-6483(10)60294-5.
Clinical trial NCT05058235: Comparison of Active Release Technique and Bent Leg Raise In Osteoarthritis.
Official title: Comparison Of Effects Of Active Release Technique And Bent Leg Raise On Hamstring Flexibility In Patients With Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Osteoarthritis
Keywords: Active Release Technique
Bent leg raise
Hamstring flexibility
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2021-09-27
Enrollment: 48
Sex: ALL
Minimum age (years): 45
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of the study was to compare the effects of active release technique and bent leg raise on hamstring flexibility, functional outcomes, and pain in patients with knee osteoarthritis.

Detailed description: Knee Osteoarthritis is a common progressive degenerative joint disease. Muscular weakness and other structural abnormalities can cause low back pain. Hamstring muscle being a postural muscle has an increased tendency to become tight. In this study, participants with knee osteoarthritis having hamstring tightness were included. Active Release Technique and Bent Leg Raise technique have been used to increase flexibility in hamstrings in these patients with knee osteoarthritis.

Eligibility criteria: Inclusion Criteria:

* Diagnosed patients of Knee Osteoarthritis
* Hamstring length less than 160 degrees
* Minimum history of 3 months
* Willing to participate

Exclusion Criteria:

* Patients who have passive knee extension more than 160 degrees
* Patients with less than 3 months history
* Patients who have osteoarthritis of other than the knee joint
* Patients with history of fracture
* Patients with post surgical history

Primary outcomes:
measure: Hamstring flexibility
timeFrame: 12 days
Secondary outcomes:
measure: Functional outcome
timeFrame: 12 days
measure: Pain on Visual analogue Scale
timeFrame: 12 days
Other outcomes:
Locations:
city: Islamabad
country: Pakistan
facility: Noor Physio and Sports Injury Clinic, G-8 Markaz
state: Federal
city: Rawalpindi
country: Pakistan
facility: Riphah Rehabilitation Center, Westridge campus, Potohar Tower, Peshawar Road
state: Punjab
Study officials:
affiliation: Riphah International University
name: Asghar Khan, Phd
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03584035: Sensorimotor Integration Exercises on Post-stroke Balance and Fall Efficacy
Official title: Effects of Sensorimotor Integration Exercises on Balance and Fall Efficacy in Sub-acute Stroke
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Keywords: sensory motor integration exercise
Lead sponsor: Mahidol University
Sponsor class: OTHER
Collaborators: name: University of Medical Technology, Yangon
First posted: 2018-07-12
Enrollment: 46
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized Control Trial
Primary purpose: TREATMENT

Brief summary: To study the effect of sensorimotor integration exercises on balance and fall efficacy in sub-acute stroke by performing 18 balance training exercises with three progressive steps.

Detailed description: Balance impairment after stroke is significantly correlated with fall risk. To improve balance and reduce fall efficacy, the participants in the study group will be trained by six weeks three progressive steps of sensorimotor integration exercises. Each exercise step will take 30 minutes of a practice session, three sessions per week. Conventional physiotherapy (passive and active exercises and lower extremities strengthening exercises) will be given to the control group. The changes in balance performance and fall efficacy will be measured and compared within and between groups.

Eligibility criteria: Inclusion Criteria:

* First episode of sub-acute stroke (from 1 to 26 weeks) referred from physicians
* Both sexes
* Age above 20
* Good cognition (Mini Mental State Examination Scale ≥24)
* Moderate and moderately severe disability (Modified Rankin Scale- 3 and 4)
* Impaired balance (BBS \<41)

Exclusion Criteria:

* Recurrent stroke
* Associated with other neurological conditions (such as Parkinson's disease, Epilepsy, meningitis)
* Deficits of somatic sensation involving the paretic limb (Fugl-Meyer Assessment - sesation\< 1)
* Lower extremity weight bearing pain (Fugl-Meyer Assessment- pain \<1)
* Low back pain (VAS ≥ 3)
* Severe visual deficits which cannot be corrected by lens or glasses
* Symptomatic vestibular disorders (Paroxysmal postural vertigo)
* Associated serious cardiac disorder

Primary outcomes:
measure: Berg Balance Scale (BBS)
timeFrame: 6 weeks
Secondary outcomes:
measure: Functional Reach Test
timeFrame: 6 weeks
measure: Fall Efficacy Scale
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Yangon
country: Myanmar
facility: National Rehabilitation Hospital
city: Yangon
country: Myanmar
facility: Physical Medicine and Rehabilitation Department, Yangon General Hospital
Study officials:
affiliation: University of Medical Technology, Yangon
name: May Phyu Phyu Maung, B.Med.Tech
role: PRINCIPAL_INVESTIGATOR
affiliation: Mahidol University
name: Thin Thin Moe, Ph.D
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Medical Technology, Yangon
name: Myo Thuzar Khin, Ph.D
role: STUDY_CHAIR
References:
Clinical trial NCT03838835: Equine Facilitated CBT Group Therapy for Youth Anxiety
Official title: Equine Facilitated Cognitive Behavioral Therapy (CBT) Group Therapy for Youth Anxiety
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Anxiety
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
First posted: 2019-02-12
Enrollment: 59
Sex: ALL
Minimum age (years): 6
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate a 10-week equine facilitated cognitive behavioral therapy (CBT) group program for youth between ages of 6 to 17 with symptoms of anxiety. The program will be delivered at GallopNYC, a stable that provides equine-facilitated group therapy to youth with a range of mental health problems.

Detailed description: The equine-facilitated group therapy normally provided at GallopNYC (Treatment as Usual, TAU) will be compared to an augmented group program that will include CBT strategies, including psychoeducation to the child and caregiver about anxiety, coping strategies to use when anxious, and identifying and addressing dysfunctional thoughts that maintain anxiety. Seventy-five children between 6 to 17 years of age will be randomized to TAU (equine-facilitated group therapy), the augmented group therapy that contains CBT strategies, or wait list control. Outcomes include anxiety symptoms, self-efficacy,receipt of services, functioning and the child's relationship with the horse.

Eligibility criteria: Inclusion Criteria:

* A child aged 6-17 seeking services for anxiety at Gallop NYC, who (based on the screener administered by GallopNYC) evidence symptoms of anxiety (as measured by a score of 2 or more on the GAD 2 item questionnaire) and a minimum functioning score of 51 (as measured by the child global assessment scale)
* Caregivers will also serve as study respondents. To do so, they must meet the following criteria:
* Primary caregiver/ legal guardian of a child who meets eligibility criteria
* Aged 18 years or older
* English speaking

Providers will serve as study therapists. To do so, they must meet the following criteria:

* PATH-certified provider employed at Gallop NYC

Exclusion Criteria:

* Inability to provide informed consent
* Child does not meet criteria for anxiety symptoms (as measured by a score of 2 or more on the GAD 2 item questionnaire) and/or does not meet minimum level of functioning (does not meet a minimum functioning score of 51 as measured by the child global assessment scale)

Primary outcomes:
measure: Anxiety, as measured by the SCARED
timeFrame: Baseline to 10 Weeks
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: NYU Langone Health
state: New York
Study officials:
affiliation: New York Langone Medical Center
name: Kimberly Hoagwood, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00863135: Effect of CPAP on Blood Pressure in Patients With Sleep Apnea and Refractory Hypertension
Official title: Effect of Continuous Positive Airway Pressure (CPAP) Treatment on Blood Pressure in Patients With Sleep Apnea and Refractory Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obstructive Sleep Apnea
Refractory Arterial Hypertension
Keywords: obstructive sleep apnea
refractory arterial hypertension
continuous positive airways pressure
Lead sponsor: Corporacion Parc Tauli
Sponsor class: OTHER
Collaborators: name: Carlos III Health Institute
First posted: 2009-03-17
Enrollment: 68
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the effects of CPAP treatment on blood pressure in patients with sleep apnea syndrome (SAS) and refractory arterial hypertension (RAH).

Also, some of the mechanisms mediating SAS and RAH (systemic inflammation, oxidative stress, sympathetic hyperactivity) will be analyzed.


Eligibility criteria: Inclusion Criteria:

* refractory arterial hypertension and sleep apnea with apnea-hypopnea index over 15

Exclusion Criteria:

* excessive sleepiness
* professional drivers
* secondary arterial hypertension

Primary outcomes:
measure: 24 hours blood pressure monitoring
timeFrame: basal and after three months of CPAP treatment
Secondary outcomes:
measure: oxidative stress and inflammatory mediators
timeFrame: basal and after three months of CPAP treatment
Other outcomes:
Locations:
city: Sabadell
country: Spain
facility: Corporacio Parc Tauli
state: Barcelona
Study officials:
affiliation: Corporació Parc Taulí
name: Jaume Almirall, Dr
role: PRINCIPAL_INVESTIGATOR
affiliation: Corporació Parc Tauli
name: Juan-Carlos Martinez-Ocaña, Dr
role: STUDY_CHAIR
affiliation: Corporacio Parc Tauli
name: Antonio Ferrer, Dr
role: STUDY_CHAIR
References:
Clinical trial NCT01411735: Evaluation of Enalapril Versus Placebo in Patients With Diastolic Heart Failure
Official title: Evaluation of Enalapril Versus Placebo in Patients With Diastolic Heart Failure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Heart Failure With Preserved Ejection Fraction
Heart Failure, Congestive
Lead sponsor: Wake Forest University Health Sciences
Sponsor class: OTHER
First posted: 2011-08-08
Enrollment: 71
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: BACKGROUND: Exercise intolerance is the primary symptom in older patients with heart failure and preserved ejection fraction (HFPEF), however little is known regarding its mechanisms and therapy.

METHODS: 71 elderly stable, compensated HFPEF patients (age 70+1 years; 80% women) with controlled blood pressure were randomized into a 12 month follow-up (FU) double-blind trial of enalapril 20 mg per day (E) vs. placebo (P). Assessments included: peak exercise oxygen consumption (VO2); six-minute walk test; Minnesota Living with HF Questionnaire (MLHF); MRI; Doppler-echocardiography; and vascular ultrasound.


Eligibility criteria: Inclusion Criteria:

* All participants will be 60 years of age or older.

Exclusion Criteria:

1. systolic dysfunction
2. patients with evidence of significant ischemic or valvular heart disease
3. chronic pulmonary disease.

Participants who appear preliminarily eligible are invited to a formal screening visiting with an investigator cardiology physician. They also undergoing a rest and exercise electrocardiogram and echocardiogram and pulmonary function testing as well as blood hematology and chemistry tests.

Final eligibility will be based upon all information available at the conclusion of the screening visits test, including hospital and outpatient records, history, physical examination, echocardiogram and exercise test.

Primary outcomes:
measure: exercise capacity and aortic distensibility
timeFrame: 9 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Professor of Medicine-Cardiology Section
name: Dalane W Kitzman, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03719235: Accuracy of Linear Measurements of Ultra-low Dose Cone Beam Computed Tomography and Digital Panoramic Radiography
Official title: Accuracy of Linear Measurements of Ultra-low Dose Cone Beam Computed Tomography and Digital Panoramic Radiography Performed on Mandibular Anaesthetic Landmarks Versus Real Mandibular Measurements
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cone Beam Computed Tomography
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2018-10-25
Enrollment: 10
Sex: ALL
Minimum age (years): 10
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: measurements performed directly on dry mandibles will be compared with measurements obtained from CBCT( ultra-low dose) scans and Digital panoramic radiography.

Detailed description: Mandibular anaesthetic landmarks will be identified on each dry mandible and will be marked using gutta percha.

The ten human dry mandibles will be submitted for:

1. Digital Panoramic Radiography. Panoramic radiographs will be obtained using the SOREDEX CRANEX™ 3Dx unit. The exposure parameters will be 8Ma, 63kVp and 16.4 sec exposure time.
2. Cone Beam Computed Tomography (CBCT). SOREDEX CRANEX™ 3Dx unit will be used in this study. Images will be acquired at a single rotation. SOREDEX® MiniDose parameters will be used. The exposure parameters will be 3.2 Ma, 90kVp and 2.3 sec exposure time to take the advantage of 3D data in dose sensitive cases like children, or reduce the radiation dose for the patient.

The real linear measurements will be measured in millimeter on dry mandibles using digital caliper and will be compared with measurements obtained from both techniques.

Images will be evaluated by two experienced radiologists of ten years of experience. Each one will evaluate the images separately twice with a period of two weeks in-between the two reading sessions. The researcher will measure out the real linear measurements on the dry mandibles using digital caliper.

Eligibility criteria: Inclusion Criteria:

* age 10 to 70 years
* no gender nor race predilection
* Either dentulous or edentulous are acceptable.

Exclusion Criteria:

* fractures
* pathology

Primary outcomes:
measure: assessment of diagnostic accuracy of linear measurements
timeFrame: within 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
Study officials:
References: