louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03029663: Complications of Transurethral Resection of the Bladder Tumour
Official title: Complications of Transurethral Resection of the Bladder Tumour: A Prospective Analysis of Incidence and Predictive Factors
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bladder Cancer
Keywords: bladder cancer
postoperative complications
Lead sponsor: Medical University of Warsaw
Sponsor class: OTHER
First posted: 2017-01-24
Enrollment: 983
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All adult patients undergoing TURBT

Brief summary: This is a prospective study enrolling consecutive patients who undergo transurethral resection of the bladder tumour (TURBT) aimed at determination of a safety of the procedure. Study end-points are incidence, severity and predictive factors of surgical complications. The study secondary aim is a validation of Clavien Dindo scoring system for reporting complication of TURBT.


Eligibility criteria: Inclusion Criteria:

* primary or recurrent bladder tumour
* informed consent to undergo the surgery

Exclusion Criteria:

* age \<18 years

Primary outcomes:
measure: Complications rate
timeFrame: 30 days postop
Secondary outcomes:
measure: Complications severity
timeFrame: 30 days postop
Other outcomes:
Locations:
city: Warsaw
country: Poland
facility: Medical University of Warsaw, Dept. of Urology
Study officials:
References:
citation: Poletajew S, Krajewski W, Gajewska D, Sondka-Migdalska J, Borowik M, Buraczynski P, Dziegala M, Lykowski M, Przudzik M, Tukiendorf A, Wozniak R, Bar K, Jablonowski Z, Roslan M, Slojewski M, Zdrojowy R, Radziszewski P, Dziobek K. Prediction of the risk of surgical complications in patients undergoing monopolar transurethral resection of bladder tumour - a prospective multicentre observational study. Arch Med Sci. 2019 Oct 7;16(4):863-870. doi: 10.5114/aoms.2019.88430. eCollection 2020.
Clinical trial NCT00368563: A Capacitance and Transepidermal Water Loss Test to Determine the Ability of Sunscreen to Moisturize Skin
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Dry Skin
Lead sponsor: Loreal USA
Sponsor class: INDUSTRY
First posted: 2006-08-24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: To evaluate the ability of 2 Helioblock SX Cream formulations to moisturize skin using capacitance and transepidermal water loss methodology


Eligibility criteria: Inclusion Criteria:

* Healthy,male or female subjects 18 years to 55 years of age, with a minimum Stanfield score at baseline of "2" at the forearm sites intended to be assessed in the study
* Female subjects of childbearing potential using a reliable form of contraception during the course of the study(oral contraceptive pill, intrauterine device, bilateral tubal ligation, abstinence, or other reliable forms at the discretion of the Investigator.) or of non childbearing potential(i.e.,post-menopausal(one year without menstrual period), hysterectomy or bilateral ovariectomy)
* Subjects who have read, understood and signed an informed consent
* Subjects who are willing and capable of cooperating to the extent and degree required by the protocol
* Absence of any visible skin diseases which might be confused with a skin reaction from the test material

Exclusion Criteria:

* Subjects with a condition, or in a situation, which in the Investigator's or Sub-Investigator's opinion, may suggest a significant hazard for the subject, may confound the study results, or may interfere with the subject's participation in the study.
* Subjects with known sensitivities to any of the study preparations or to other skin care products
* Subjects who have participated in a clinical research study, including consumer products studies, within the last 30 days prior to enrollment
* Subjects who are currently receiving medication(prescription or OTC) that in the opinion of the Investigator may interfere with the evaluations made in this study (e.g.vasoactive substances)
* Pregnant or nursing females or women who are planning to get pregnant during the study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Scottsdale
country: United States
facility: Hill Top Research
state: Arizona
Study officials:
affiliation: Hill Top Research
name: Linda Oddo, B.S.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02867163: Tranexamic Acid and Blood Clots in Knee Surgery
Official title: Does the Intraoperative Administration of Tranexamic Acid (TXA) Increase the Incidence of Deep Venous Thrombosis in Total Knee Arthroplasty?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Venous Thrombosis
Lead sponsor: University of New Mexico
Sponsor class: OTHER
First posted: 2016-08-15
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients having total knee replacement at Sandoval Regional Medical Center in Rio Rancho, New Mexico, and who receive an intraoperative dose of tranexamic acid to control surgical bleeding

Brief summary: This is an observational trial to estimate the incidence of deep vein thrombosis (DVT) in total knee replacement patients who received an intraoperative dose of tranexamic acid.

Detailed description: This study is anticipated to consist of 30 participants over 18 years of age scheduled for total knee arthroplasty at Sandoval Regional Medical Center with administered intraoperative tranexamic acid, who do not meet the exclusion criteria. The patients will be examined on postoperative day 1. Lower-extremity ultrasound will be used to screen for deep vein thrombosis (DVT). Incidence data for DVT will then be compared with the historical incidence rate at our institution for total knee arthroplasty without the use of tranexamic acid, which is approximately 12%. Patients found on screening to have deep vein thrombosis will be referred for appropriate care.

Eligibility criteria: Inclusion Criteria:

* Adult patients scheduled for total knee arthroplasty at Sandoval Regional Medical Center with an intraoperative dose of tranexamic acid

Exclusion Criteria:

* Previous deep vein thrombosis or pulmonary embolism episode
* Known coronary artery disease or peripheral vascular disease
* Previously diagnosed hypercoagulable states (e.g. Leiden factor V, antiphospholipid antibody, protein C or S deficiency)
* Pregnancy
* Creatinine clearance less than 30 ml/min
* Non-fluency in English

Primary outcomes:
measure: Deep Vein Thrombosis
timeFrame: One day
Secondary outcomes:
Other outcomes:
Locations:
city: Rio Rancho
country: United States
facility: Sandoval Regional Medical Center
state: New Mexico
Study officials:
affiliation: University of New Mexico
name: David Siegel, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06677463: An Evaluation of Virtual Reality in Labor Pain During Vaginal Childbirth
Official title: An Evaluation of Virtual Reality in Labor Pain During Vaginal Childbirth
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: An Evaluation of Virtual Reality in Labor Pain During Vaginal Childbirth
Lead sponsor: Kafrelsheikh University
Sponsor class: OTHER
First posted: 2024-11-06
Enrollment: 80
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: This study will be conducted to evaluate the effect of applying virtual reality among laboring women during first stage of labor
Primary purpose: OTHER

Brief summary: This study will be conducted to evaluate the effect of applying virtual reality among laboring women during first stage of labor

Detailed description: This study will be conducted to evaluate the effect of applying virtual reality among laboring women during first stage of labor

Eligibility criteria: Inclusion Criteria:

* Age between 20-25 years old .
* body mass index (BMI) 25- 32 kg/m2 .
* Primiparous .
* Highly educated.

Exclusion Criteria:

* Laboring women with high risk pregnancy.
* Laboring women are taking pharmacological methods to relieve pain during first stage of labor.
* Low educated women

Primary outcomes:
measure: Serum cortisol levels
timeFrame: Immediately after the intervention
measure: Time of labor
timeFrame: Immediately after the intervention
measure: Type of labor normal , cesarean section or episiotomy
timeFrame: Immediately after the intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Menshawy general hospital
state: Gharabia
Study officials:
affiliation: Fayiz Elshamy
name: Fayiz Elshamy Elshamy Fayiz Elshamy, Professor of physical therapy
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01573663: A Drug-Drug Interaction Study of Ambroxol and Levodropropizine
Official title: Open Label, Randomized, 3-sequence Crossover Study to Evaluate the Drug-drug Interaction Between Ambroxol HCl and Levodropropizine in Healthy Male Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Keywords: Ambroxol
Levodropropizine
Drug-drug interaction
Lead sponsor: Hanmi Pharmaceutical Company Limited
Sponsor class: INDUSTRY
First posted: 2012-04-09
Enrollment: 21
Sex: MALE
Minimum age (years): 20
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the drug-durg interaction between ambroxol and levodropropizine.


Eligibility criteria: Inclusion Criteria:

* Healthy male
* Age between 20 and 55
* Signed informed consent

Exclusion Criteria:

* Has a history of hypersensitivity to IP ingredients
* Hypotension or hypertension
* Has a history of acute infection within 14 days of screening

Primary outcomes:
measure: AUClast
timeFrame: 0-48hrs
measure: Cmax
timeFrame: 0-48hrs
Secondary outcomes:
measure: Tmax
timeFrame: 0-48hrs
measure: T1/2
timeFrame: 0-48hrs
measure: AUCinf
timeFrame: 0-48hrs
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung medical center
Study officials:
affiliation: Samsung Medical Center
name: Wooseong Huh, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02821663: Vocal Intervention in Systemic Sclerosis
Official title: Rehabilitation in Patients Suffering From Systemic Sclerosis by Vocal Intervention: A Pilot Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Systemic Sclerosis
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2016-07-01
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Systemic sclerosis is a systemic connective tissue disease with physical and mental disturbances. Based on a pilot study the feasibility and effectiveness of a novel, self-developed concept of vocal intervention in Systemic Sclerosis under vocal pedagogical guidance and music therapy is assessed.

Detailed description: This concept aims at functional improvement of respiration and mouth-opening, enhancement of Quality of Life, and reduction of stress carried out by a music therapist and singer with pedagogical formation.

Eligibility criteria: Inclusion Criteria:

* positive criteria for Systemic Sclerosis according to the American College of Rheumatology/European League Against Rheumatism

Exclusion Criteria:

* affection of the vocal apparatus
* dyspnea at rest
* oxygen prescription

Primary outcomes:
measure: MOS 36-Item Short Form Health Survey
timeFrame: up to 4 weeks
Secondary outcomes:
measure: Mouth open; in millimeter
timeFrame: up to 4 weeks
measure: 6-minutes walk test
timeFrame: up to 4 weeks
measure: Secretory immunoglobulin A; mg/l
timeFrame: up to 4 weeks
measure: Saliva cortisol; ng/ml
timeFrame: up to 4 weeks
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Department of Physical Medicine and Rehabilitation, Medical University of Vienna
Study officials:
affiliation: Deptartment of Physical Medicine and Rehabilitation, MUW
name: Michael Mickel, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04718363: Effects of Foam Rolling Prior to PNF Stretching on Hamstring Flexibility and Thigh Skin Temperature in Healthy Subjects
Official title: Effects of Foam Roller Application Prior to Proprioceptive Neuromuscular Facilitation Stretching on Hamstring Flexibility and Thigh Skin Temperature in Healthy Subjects
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy
Keywords: hamstring muscles
PNF stretching
foam rolling
thermal imaging
flexibility
range of motion
vibration
Lead sponsor: Dokuz Eylul University
Sponsor class: OTHER
First posted: 2021-01-22
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: There is no study investigating the hamstring flexibility and skin temperature after combined warm-up techniques especially PNF and foam rolling. The main purpose of this study is to investigate the effects of foam roller application prior to proprioceptive neuromuscular facilitation stretching on hamstring flexibility and thigh skin temperature in healthy subjects.Secondly, it is aimed to compare the effects between non-vibration foam rolling and vibration foam rolling on measured parameters.

Detailed description: In this study forty-eight subjects will be voluntarily recruited into the study according to inclusion criteria. Participants will be randomly assigned to Vibration Foam Rolling + PNF stretching, Non-Vibration Foam Rolling + PNF stretching, only PNF stretching and control group. Subjects will be evaluated before, immediately after and 30 minutes after intervention. Hamstring flexibility will be evaluated with Active Knee Extension Angle (AKEA) Test and functionally Sit and Reach test. Thigh skin temperature will be evaluated with thermographic imaging.

Eligibility criteria: Inclusion Criteria:

* 18 years and older,
* Having limitation of 20 degrees or more in knee extension angle in AKEA test,
* Right side lower extremity dominance

Exclusion Criteria:

* History of lower extremity injury in the last 12 months
* Having neurological or psychological problem
* Doing a stretching based exercise recently
* History of pain in the lower body and extremity in the Nordic Musculoskeletal Questionnaire
* Having lower extremity deformity

Primary outcomes:
measure: Change in hamstring flexibility
timeFrame: Change from baseline hamstring flexibility at immediately after intervention and 30 minutes after intervention
measure: Change in thigh skin temperature
timeFrame: Change from baseline skin temperature at immediately after intervention and 30 minutes after intervention
measure: Change in functional hamstring flexibility
timeFrame: Change from baseline functional hamstring flexibility at immediately after intervention and 30 minutes after intervention
Secondary outcomes:
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: Dokuz Eylul University
Study officials:
References:
Clinical trial NCT04030663: The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter
Official title: The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter Prior to Cannulation.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Radial Artery Injury Prevetion
Lead sponsor: Kasr El Aini Hospital
Sponsor class: OTHER
First posted: 2019-07-24
Enrollment: 90
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Compare the effect of periradial injection of papaverine versus nitroglycerine on radial artery diamter before cannulation of it in cardiac surgery.

Detailed description: we want in this study to facilitate radial artery canulation and decrease the number of attemps of puncture which may lead to disappearance of the pulse.

The aim of this study is to compare the effect of adding papaverine to local anesthetic xylocaine versus adding nitroglycerine to it on the diameter and palpability of radial artery and if perioperative spasm will decrease significantly with one of these methods.

Eligibility criteria: Inclusion Criteria:

- Patients who will be included in the study are those scheduled for elective cardiac surgery who are hemodynamically stable.

Exclusion Criteria:

* Any patient with negative modified Allen test, atrioventricular block, glaucoma, altered liver function, unstable hemodynamics, emergency surgeries, and peripheral vascular disease.

Primary outcomes:
measure: diameter of radial artery
timeFrame: 20 minutes
Secondary outcomes:
measure: spasm of radial artery
timeFrame: 24 hours
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Medicine
state: Benisuef
Study officials:
References:
Clinical trial NCT06529263: The Effect of Newborn Massage on Comfort Level and Vital Signs
Official title: The Effect of Newborn Massage on Comfort Level and Vital Signs
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Newborn
Keywords: Newborn
infant massage
vital signs
comfort
Lead sponsor: Istanbul Medipol University Hospital
Sponsor class: OTHER
First posted: 2024-07-31
Enrollment: 30
Sex: ALL
Minimum age (years): 1
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled experimental study
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study was planned as a randomized, controlled, experimental study to examine the effect of neonatal massage on the comfort level and vital signs of newborn babies.An answer to the question "Does massage applied to infants in the neonatal period have an effect on vital signs and comfort level?" will be sought.

Detailed description: The sample of the study consisted of a total of 60 infants, 30 in the experimental group and 30 in the control group, who were hospitalized in the Neonatal Intensive Care Unit of a City Hospital between December 2022 and April 2023, whose parents' written and verbal consent was obtained for participation in the study after being informed, and who met the inclusion criteria. "Data Collection Form", 'Life Findings Assessment Form' and 'Newborn Comfort Behaviors Scale' prepared by the researchers were used as data collection tools. Newborns in the experimental group were massaged twice a day for 15 minutes 30 minutes after feeding and routine care for 4 days. The data obtained in the study will be analyzed using SPSS (Statistical Package for Social Sciences) for Windows 22.0 program.

Eligibility criteria: Inclusion Criteria:

* Gestational age between 37-42 weeks,
* Birth weight of 2500 grams and above,
* The infant was hospitalized in the Neonatal Intensive Care Unit during data collection,
* Completion of 24 hours after birth

Exclusion Criteria:

* Gestational age below 37 weeks,
* Birth weight below 2500 grams,
* Refusal of the parent to participate in the study,
* The baby is on mechanical ventilation

Primary outcomes:
measure: Body temperature
timeFrame: Measurements were taken before and after the newborn massage 2 times a day for 4 days.
measure: Pulse
timeFrame: Measurements were taken before and after the newborn massage 2 times a day for 4 days.
measure: Respiration
timeFrame: Measurements were taken before and after the newborn massage 2 times a day for 4 days.
measure: Understanding Pulse Oximetry
timeFrame: Measurements were taken before and after the newborn massage 2 times a day for 4 days.
measure: Newborn comfort behaviors scale
timeFrame: Measurements were taken before and after the newborn massage 2 times a day for 4 days.
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Medipol University
state: Beykoz
Study officials:
affiliation: Faculty Member
name: Aysel Kokcu Dogan
role: STUDY_DIRECTOR
References:
Clinical trial NCT01633463: An Observational Study of Pain Assessment and Treatment Adequacy of Emergency Cancer Pain
Official title: A Prospective Observational Study of Assessment of Pain and Its Treatment Adequacy in Emergency Department at Tertiary Care Cancer Hospital.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: OBSERVE PAIN MANAGEMENT PRACTICES IN EMERGENCY DEPARTMENT
Keywords: EMERGENCY CANCER PAIN, ASSESSMENT, TREATMENT ADEQUACY.
Lead sponsor: Tata Memorial Hospital
Sponsor class: OTHER_GOV
First posted: 2012-07-04
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 100 ADULT CANCER PATIENTS REPORTING TO EMERGENCY DEPARTMENT WITH COMPLAINTS OF PAIN.

Brief summary: EMERGENCY CANCER PAIN DRAWS CANCER PATIENT TO EMERGENCY DEPARTMENT FOR TREATMENT. HOWEVER, THERE HAS BEEN INCONSISTENCY AND INADEQUACY OF PAIN MANAGEMENT IN EMERGENCY DEPARTMENT. THIS STUDY OBSERVES THE STATUS OF PAIN ASSESSMENT AND ITS ADEQUACY IN EMERGENCY DEPARTMENT IN A TERTIARY CARE CANCER HOSPITAL.


Eligibility criteria: Inclusion Criteria:

* ADULT CANCER PATIENTS REPORTING TO EMERGENCY DEPARTMENT WITH COMPLAINTS OF PAIN

Exclusion Criteria:

* 1.PATIENTS BELOW 18 YEARS OF AGE, 2. PATIENTS WITH INCOHERENT BEHAVIOUR.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Mumbai, Parel
country: India
facility: Tata Memorial Hospital
state: Maharashtra
Study officials:
affiliation: Tata Memorial Centre
name: SWAPNIL Y PARAB, MD
role: PRINCIPAL_INVESTIGATOR
References: