Clinical trial NCT06614439: PG Versus TG for Advanced PGC
Official title: Proximal Versus Total Gastrectomy for Advanced Proximal Gastric Cancer: A Retrospective Double-Center Propensity Score-Matched Cohort Study
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Gastric Adenocarcinoma
Gastrectomy
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2024-09-26
Enrollment: 96
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: We conducted a retrospective study on patients with pathological stage II-III PGC who underwent PG or TG from 2013 to 2023. Propensity score-matching was applied to adjust for tumor size and stage between the PG and TG groups at a 1:1 ratio. We evaluated the procedural safety, oncological, and functional outcomes.


Eligibility criteria: Inclusion Criteria:

* Proximal gastric adenocarcinoma after total or proximal gastrectomy.

Exclusion Criteria:

* Non-curative resections
* Non-adenocarcinoma histology
* Distally located tumors or middle/proximally located tumors for which distal margin could not be secured by PG
* Remnant gastric cancer
* Clinically T1N0 tumors smaller than 3 cm for which PG was clearly indicated

Primary outcomes:
measure: five-year overall survival
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Hsin-Chu County
country: Taiwan
facility: National Taiwan University Hospital Hsin-Chu Branch
Study officials:
References:
citation: Lee S, Chae YS, Yun WG, Kim JC, Park JK, Kim MG, Kim J, Cho YS, Kong SH, Park DJ, Lee HJ, Yang HK. Long-Term Outcome of Proximal Gastrectomy for Upper-Third Advanced Gastric and Siewert Type II Esophagogastric Junction Cancer Compared With Total Gastrectomy: A Propensity Score-Matched Analysis. Ann Surg Oncol. 2024 May;31(5):3024-3030. doi: 10.1245/s10434-024-15048-8. Epub 2024 Feb 19.
citation: Peng R, Yue C, Wei W, Zhou B, Wen X, Gu RM, Ming XZ, Li G, Chen HQ, Xu ZK. Proximal gastrectomy may be a reasonable choice for patients with selected proximal advanced gastric cancer: A propensity score-matched analysis. Asian J Surg. 2022 Oct;45(10):1823-1831. doi: 10.1016/j.asjsur.2021.09.029. Epub 2021 Oct 9.
citation: Rosa F, Quero G, Fiorillo C, Bissolati M, Cipollari C, Rausei S, Chiari D, Ruspi L, de Manzoni G, Costamagna G, Doglietto GB, Alfieri S. Total vs proximal gastrectomy for adenocarcinoma of the upper third of the stomach: a propensity-score-matched analysis of a multicenter western experience (On behalf of the Italian Research Group for Gastric Cancer-GIRCG). Gastric Cancer. 2018 Sep;21(5):845-852. doi: 10.1007/s10120-018-0804-3. Epub 2018 Feb 8.
citation: Sugoor P, Shah S, Dusane R, Desouza A, Goel M, Shrikhande SV. Proximal gastrectomy versus total gastrectomy for proximal third gastric cancer: total gastrectomy is not always necessary. Langenbecks Arch Surg. 2016 Aug;401(5):687-97. doi: 10.1007/s00423-016-1422-3. Epub 2016 May 4.
citation: Lee S, Son WJ, Roh YH, Song JH, Park SH, Cho M, Kim YM, Hyung WJ, Kim HI. Indication of Proximal Gastrectomy for Advanced Proximal Gastric Cancer Based on Lymph Node Metastasis at the Distal Part of the Stomach. Ann Surg Open. 2021 Nov 24;2(4):e107. doi: 10.1097/AS9.0000000000000107. eCollection 2021 Dec.