Clinical trial NCT06653153: A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)
Official title: A Study of Remternetug Versus Placebo in Early Alzheimer's Disease Participants at Risk for Cognitive and Functional Decline
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Alzheimer's Disease
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
First posted: 2024-10-22
Enrollment: 1200
Sex: ALL
Minimum age (years): 55
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to measure the difference in time to developing or worsening memory, thinking, or functional problems due to Alzheimer's disease occurring in participants receiving study drug compared to placebo.

Participation could last up to 255 weeks including screening, a double-blind treatment period, and a double-blind observation period. In addition, eligible participants who receive placebo during the double-blind treatment period may choose to extend their study participation to receive open-label remternetug in an extension period.


Eligibility criteria: Inclusion Criteria:

* Have a phosphorylated tau (P-tau) result consistent with the presence of amyloid pathology.
* Have a reliable study partner and backup study partner familiar with overall function and behavior, such as day-to-day activities and cognitive abilities.
* Have adequate literacy, vision, and hearing for neuropsychological testing at screening.
* Have a Mini Mental Status Exam (MMSE) score consistent with no to minimal cognitive impairment.
* Have a Functional Activities Questionnaire (FAQ) score consistent with no to minimal functional impairment.
* If currently receiving medications as symptomatic treatment for AD, dose has been stable for at least 30 days before screening.

Exclusion Criteria:

* Have dementia or significant other neurological disease that can affect cognition.
* Have current serious or unstable illnesses that in the investigator's opinion, could interfere with the analyses of the study.
* Have a history of cancer that, in the investigator's opinion, has a high risk of recurrence.
* Have a history of clinically significant multiple or severe drug allergies, or hypersensitivity reactions.
* Have a clinically important laboratory test result or other abnormality as determined by investigator, prior to randomization, that could be detrimental to the participant or could compromise the study.
* Have any contraindications for magnetic resonance imaging (MRI).
* Have a centrally read MRI that does not meets study entry criteria.

Prior or Current Therapies

* Have ever had prior treatment with a passive anti-amyloid immunotherapy.
* Have received active immunization against Aβ in any other study.

Primary outcomes:
measure: Time to Clinically Meaningful Progression as Measured by Clinical Dementia Rate (CDR)
timeFrame: Baseline to Time to Event up to Week 255
Secondary outcomes:
measure: Change from Baseline in Clinical Dementia Rate Box Score (SB)
timeFrame: Baseline, Week 255
measure: Change from Baseline in Montreal Cognitive Assessment (MoCA)
timeFrame: Baseline, Week 255
measure: Change from Baseline in the Category Fluency - Language, Executive Function, Semantic Memory
timeFrame: Baseline, Week 255
measure: Change from Baseline in the Continuous Paired Associate Learning (CPAL)
timeFrame: Baseline, Week 255
measure: Change from Baseline in International Shopping List Test (ISLT) - Verbal Episodic Mem
timeFrame: Baseline, Week 255
measure: Change from Baseline in International Daily Symbol Substitution Test-Medicines (iDSSTm) - Complex Attention Memory
timeFrame: Baseline, Week 255
measure: Change from Baseline in Cogstate Brief Battery (CBB) - Psychomotor Function, Attention, Learning and Working Memory
timeFrame: Baseline, Week 255
measure: Change from Baseline in Cognitive Function Index (CFI)
timeFrame: Baseline, Week 255
measure: Change from Baseline in Mild Behavioral Impairment Checklist (MBI-C)
timeFrame: Baseline, Week 255
measure: Change from Baseline in Alzheimer's Disease Cooperative Study (ADCS) Activities of Daily Living - Prevention Instrument (ADCS-ADL-PI)
timeFrame: Baseline, Week 255
measure: Pharmacokinetics: Serum Concentrations of Remternetug
timeFrame: Baseline through Week 255
measure: Number of Participants with Treatment Emergent Anti-Drug Antibodies (TE-ADAs)
timeFrame: Baseline through Week 255
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Parkway Medical Center
state: Alabama
city: Chandler
country: United States
facility: MD First Research - Chandler
state: Arizona
city: Mesa
country: United States
facility: Care Access - 801 South Power Road, Mesa
state: Arizona
city: Phoenix
country: United States
facility: Banner Alzheimer's Institute
state: Arizona
city: Tucson
country: United States
facility: Banner Alzheimer's Institute Tucson
state: Arizona
city: Fresno
country: United States
facility: Neuro-Pain Medical Center
state: California
city: Huntington Beach
country: United States
facility: Care Access - Huntington Beach
state: California
city: Inglewood
country: United States
facility: Inglewood Clinical
state: California
city: Irvine
country: United States
facility: Irvine Clinical Research
state: California
city: Long Beach
country: United States
facility: Healthy Brain Clinic
state: California
city: Riverside
country: United States
facility: Riverside Clinical
state: California
city: Sacramento
country: United States
facility: Clinical Trials Research
state: California
city: San Diego
country: United States
facility: Artemis Institute for Clinical Research
state: California
city: San Diego
country: United States
facility: Sharp Neurocognitive Research Center
state: California
city: San Francisco
country: United States
facility: Ray Dolby Brain Health Center
state: California
city: San Marcos
country: United States
facility: The Neuron Clinic - San Marcos
state: California
city: Santa Ana
country: United States
facility: Syrentis Clinical Research
state: California
city: Santa Rosa
country: United States
facility: Providence Medical Foundation
state: California
city: Sherman Oaks
country: United States
facility: California Neuroscience Research, LLC
state: California
city: Aurora
country: United States
facility: Care Access - Aurora
state: Colorado
city: Basalt
country: United States
facility: Mountain Neurological Research Center
state: Colorado
city: Boulder
country: United States
facility: Alpine Clinical Research Center
state: Colorado
city: Englewood
country: United States
facility: CenExel Rocky Mountain Clinical Research
state: Colorado
city: New Haven
country: United States
facility: Invicro
state: Connecticut
city: Stamford
country: United States
facility: Ki Health Partners, LLc, dba New England Institute for Clinical Research
state: Connecticut
city: Atlantis
country: United States
facility: JEM Research Institute
state: Florida
city: Aventura
country: United States
facility: VIN-Julie Schwartzbard
state: Florida
city: Bradenton
country: United States
facility: Bradenton Research Center, Inc.
state: Florida
city: Clermont
country: United States
facility: K2 Medical Research WINTER GARDEN
state: Florida
city: Davie
country: United States
facility: TecTum Research
state: Florida
city: Delray Beach
country: United States
facility: Brain Matters Research
state: Florida
city: Fort Myers
country: United States
facility: Neuropsychiatric Research Center of Southwest Florida
state: Florida
city: Hialeah
country: United States
facility: Indago Research & Health Center, Inc
state: Florida
city: Lady Lake
country: United States
facility: K2 MEDICAL Research THE VILLAGES
state: Florida
city: Maitland
country: United States
facility: ClinCloud
state: Florida
city: Maitland
country: United States
facility: K2 Medical Research ORLANDO
state: Florida
city: Melbourne
country: United States
facility: ClinCloud
state: Florida
city: Merritt Island
country: United States
facility: Merritt Island Medical Research, LLC
state: Florida
city: Miami
country: United States
facility: VIN-Andrew Lerman
state: Florida
city: Miami
country: United States
facility: New Age Medical Research Corporation
state: Florida
city: Mount Dora
country: United States
facility: Adult Medicine of Lake County, Inc.
state: Florida
city: Naples
country: United States
facility: Aqualane Clinical Research
state: Florida
city: New Port Richey
country: United States
facility: Suncoast Clinical Research, Inc.
state: Florida
city: Ocala
country: United States
facility: Renstar Medical Research
state: Florida
city: Orlando
country: United States
facility: Charter Research - Winter Park
state: Florida
city: Orlando
country: United States
facility: AdventHealth Orlando
state: Florida
city: Pensacola
country: United States
facility: Emerald Coast Neurology - Airport Boulevard
state: Florida
city: Port Orange
country: United States
facility: Progressive Medical Research
state: Florida
city: Stuart
country: United States
facility: Alzheimer's Research and Treatment Center
state: Florida
city: Tampa
country: United States
facility: Axiom Brain Health LLC
state: Florida
city: Tampa
country: United States
facility: Stedman Clinical Trials
state: Florida
city: Tampa
country: United States
facility: Care Access - Tampa
state: Florida
city: The Villages
country: United States
facility: Charter Research - Lady Lake
state: Florida
city: Wellington
country: United States
facility: Alzheimer's Research and Treatment Center
state: Florida
city: West Palm Beach
country: United States
facility: Palm Beach Neurology
state: Florida
city: Winter Park
country: United States
facility: Conquest Research
state: Florida
city: Columbus
country: United States
facility: Columbus Memory Center, LLC
state: Georgia
city: Decatur
country: United States
facility: Care Access - Decatur
state: Georgia
city: Gainesville
country: United States
facility: Center for Advanced Research & Education
state: Georgia
city: Woodstock
country: United States
facility: North Georgia Clinical Research
state: Georgia
city: Boise
country: United States
facility: Northwest Clinical Trials
state: Idaho
city: Arlington Heights
country: United States
facility: Care Access - Arlington Heights
state: Illinois
city: Chicago
country: United States
facility: Re:Cognition Health - Chicago
state: Illinois
city: Chicago
country: United States
facility: Great Lakes Clinical Trials - Andersonville
state: Illinois
city: Elk Grove Village
country: United States
facility: Alexian Brothers Medical Center
state: Illinois
city: Indianapolis
country: United States
facility: Care Access - South Indianapolis
state: Indiana
city: Indianapolis
country: United States
facility: Josephson Wallack Munshower Neurology, PC
state: Indiana
city: Waterloo
country: United States
facility: Cedar Valley Medical Specialists
state: Iowa
city: Topeka
country: United States
facility: Cotton O'Neil Clinical Research Center
state: Kansas
city: Lake Charles
country: United States
facility: Care Access - Lake Charles (Bayou Pines)
state: Louisiana
city: Marrero
country: United States
facility: Tandem Clinical Research
state: Louisiana
city: Bangor
country: United States
facility: Acadia Hospital
state: Maine
city: Baltimore
country: United States
facility: Care Access - Baltimore
state: Maryland
city: Boston
country: United States
facility: Copley Clinical
state: Massachusetts
city: Boston
country: United States
facility: Boston Clinical Trials
state: Massachusetts
city: Newton
country: United States
facility: Boston Center for Memory
state: Massachusetts
city: Quincy
country: United States
facility: Care Access - Quincy
state: Massachusetts
city: Waltham
country: United States
facility: MedVadis Research Corporation
state: Massachusetts
city: Watertown
country: United States
facility: Adams Clinical
state: Massachusetts
city: Dearborn
country: United States
facility: Revival Research Institute, LLC
state: Michigan
city: Farmington Hills
country: United States
facility: QUEST Research Institute
state: Michigan
city: Saint Paul
country: United States
facility: HealthPartners Neuroscience Center
state: Minnesota
city: Hattiesburg
country: United States
facility: Private Practice - Dr. Ronald Louis Schwartz
state: Mississippi
city: Bolivar
country: United States
facility: Citizens Memorial Hospital District
state: Missouri
city: Chesterfield
country: United States
facility: Clinical Research Professionals
state: Missouri
city: Omaha
country: United States
facility: University Of Nebraska Medical Center
state: Nebraska
city: Las Vegas
country: United States
facility: Vector Clinical Trials
state: Nevada
city: Hoboken
country: United States
facility: Care Access - Hoboken
state: New Jersey
city: Ridgewood
country: United States
facility: The Cognitive and Research Center of New Jersey - Ridgewood
state: New Jersey
city: Springfield
country: United States
facility: The Cognitive and Research Center of New Jersey
state: New Jersey
city: Toms River
country: United States
facility: Advanced Memory Research Institute of New Jersey
state: New Jersey
city: Albuquerque
country: United States
facility: IMA Clinical Research
state: New Mexico
city: Charlotte
country: United States
facility: Care Access - Charlotte
state: North Carolina
city: Greensboro
country: United States
facility: Medication Management
state: North Carolina
city: Monroe
country: United States
facility: Monroe Biomedical Research
state: North Carolina
city: Lima
country: United States
facility: Care Access - Lima
state: Ohio
city: Middleburg Heights
country: United States
facility: North Star Medical Research
state: Ohio
city: Portland
country: United States
facility: Summit Headlands
state: Oregon
city: Philadelphia
country: United States
facility: Clinical Research of Philadelphia
state: Pennsylvania
city: Plymouth Meeting
country: United States
facility: Keystone Clinical Studies
state: Pennsylvania
city: East Providence
country: United States
facility: Rhode Island Mood & Memory Research Institute
state: Rhode Island
city: Providence
country: United States
facility: Butler Hospital
state: Rhode Island
city: Greenville
country: United States
facility: Tribe Clinical Research, LLC
state: South Carolina
city: Summerville
country: United States
facility: Palmetto Clinical Research
state: South Carolina
city: Cordova
country: United States
facility: Neurology Clinic, P.C.
state: Tennessee
city: Knoxville
country: United States
facility: Genesis Neuroscience Clinic
state: Tennessee
city: Austin
country: United States
facility: Senior Adults Specialty Research
state: Texas
city: Beaumont
country: United States
facility: Gadolin Research
state: Texas
city: Dallas
country: United States
facility: Kerwin Medical Center - Oak Cliff
state: Texas
city: Dallas
country: United States
facility: Kerwin Medical Center
state: Texas
city: Georgetown
country: United States
facility: Care Access - Georgetown
state: Texas
city: Houston
country: United States
facility: Care Access - Houston
state: Texas
city: Houston
country: United States
facility: The University of Texas Health Science Center at Houston
state: Texas
city: Houston
country: United States
facility: Next Level Urgent Care
state: Texas
city: Rio Grande City
country: United States
facility: El Faro Health and Therapeutics
state: Texas
city: Round Rock
country: United States
facility: Central Texas Neurology Consultants, PA
state: Texas
city: San Antonio
country: United States
facility: IMA Clinical Research San Antonio
state: Texas
city: Shavano Park
country: United States
facility: Consano Clinical Research, LLC
state: Texas
city: Arlington
country: United States
facility: Care Access - Arlington
state: Virginia
city: Fairfax
country: United States
facility: Re:Cognition Health
state: Virginia
city: Norfolk
country: United States
facility: Eastern Virginia Medical School (EVMS) Medical Group
state: Virginia
city: Bellevue
country: United States
facility: Northwest Clinical Research Center
state: Washington
city: Renton
country: United States
facility: Rainier Clinical Research Center
state: Washington
city: Ciudad de Buenos Aires
country: Argentina
facility: IDIM - Instituto de Investigaciones Metabólicas
state: Buenos Aires
city: ABB
country: Argentina
facility: Hospital Italiano de Buenos Aires
state: Ciudad Autónoma De Buenos Aires
city: Rosario
country: Argentina
facility: Fundacion Estudios Clinicos
state: Santa Fe
city: Rosario
country: Argentina
facility: Instituto de Investigaciones Clinicas Rosario
state: Santa Fe
city: SAN M. DE Tucuman
country: Argentina
facility: Centro de Investigaciones Médicas Tucuman
state: Tucumán
city: Buenos Aires
country: Argentina
facility: Instituto de Neurología Cognitiva (INECO)
city: Buenos Aires
country: Argentina
facility: Instituto Médico Especializado (IME)
city: Buenos Aires
country: Argentina
facility: CIPREC
city: Buenos Aires
country: Argentina
facility: Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI)
city: Buenos Aires
country: Argentina
facility: Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)
city: Ciudad Autónoma de Buenos Aires
country: Argentina
facility: Instituto Argentino de Investigación Neurológica (IADIN)
city: Ciudad Autónoma de Buenos Aires
country: Argentina
facility: Centro Médico Arsema
city: Córdoba
country: Argentina
facility: CEN Centro Especializado en Neurociencias
city: Córdoba
country: Argentina
facility: Instituto Kremer
city: Mendoza
country: Argentina
facility: Fundacion Scherbovsky
city: Santa Fe
country: Argentina
facility: Centro de Diagnóstico y Rehabilitación (CEDIR)
city: Botany
country: Australia
facility: Emeritus Research
state: New South Wales
city: East Maitland
country: Australia
facility: GenesisCare - Maitland
state: New South Wales
city: Kogarah
country: Australia
facility: Southern Neurology
state: New South Wales
city: Macquarie Park
country: Australia
facility: KARA Institute for Neurological Diseases
state: New South Wales
city: Sydney
country: Australia
facility: St Vincent's Hospital
state: New South Wales
city: Birtinya
country: Australia
facility: USC Clinical Trials Sunshine Coast
state: Queensland
city: Herston
country: Australia
facility: The University of Queensland
state: Queensland
city: Ipswich
country: Australia
facility: Ipswich Hospital
state: Queensland
city: South Brisbane
country: Australia
facility: USC Clinical Trials Brisbane (South Bank)
state: Queensland
city: Norwood
country: Australia
facility: Fusion Clinical Research
state: South Australia
city: Woodville
country: Australia
facility: The Queen Elizabeth Hospital
state: South Australia
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: Camberwell
country: Australia
facility: Emeritus Research
state: Victoria
city: Ivanhoe
country: Australia
facility: Austin Health
state: Victoria
city: Malvern
country: Australia
facility: HammondCare
state: Victoria
city: Parkville
country: Australia
facility: The Royal Melbourne Hospital
state: Victoria
city: Nedlands
country: Australia
facility: Alzheimer's Research Australia
state: Western Australia
city: Kelowna
country: Canada
facility: OCT Research ULC
state: British Columbia
city: West Vancouver
country: Canada
facility: The Medical Arts Health Research Group - West Vancouver
state: British Columbia
city: Ottawa
country: Canada
facility: Ottawa Memory Clinic
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Centre - Redefining Healthy Aging
state: Ontario
city: Sarnia
country: Canada
facility: Bluewater Clinical Research Group Inc.
state: Ontario
city: Toronto
country: Canada
facility: Toronto Memory Program
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Research Institute
state: Ontario
city: Toronto
country: Canada
facility: Baycrest Health Sciences
state: Ontario
city: Chicoutimi
country: Canada
facility: Ecogene-21 - Cmas
state: Quebec
city: Greenfield Park
country: Canada
facility: MoCA Research and Innovation Inc.
state: Quebec
city: Lévis
country: Canada
facility: Alpha Recherche Clinique - Lévis
state: Quebec
city: Montreal
country: Canada
facility: Genge Partners
state: Quebec
city: Montréal
country: Canada
facility: Clinique Mémoire de Montréal
state: Quebec
city: Sherbrooke
country: Canada
facility: Q&T Research Sherbrooke Inc.
state: Quebec
city: Victoriaville
country: Canada
facility: Diex Recherche Victoriaville
state: Quebec
city: Quebec
country: Canada
facility: Alpha Recherche Clinique
city: Quebec
country: Canada
facility: ALPHA Recherche Clinique
city: Hefei
country: China
facility: Anhui Provincial Hospital
state: Anhui
city: Beijing
country: China
facility: Beijing Tiantan Hospital Affiliated to Capital Medical University
state: Beijing
city: Beijing
country: China
facility: Beijing Anding Hospital - Affiliated Capital University of Medical Science
state: Beijing
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
state: Guangdong
city: Guangzhou
country: China
facility: Guangzhou First People's Hospital
state: Guangdong
city: Guangzhou
country: China
facility: Guangzhou Medical University 2nd Hospital
state: Guangdong
city: Guangzhou
country: China
facility: Zhujiang Hospital
state: Guangdong
city: Shijiazhuang
country: China
facility: The First Hospital of Hebei Medical University
state: Hebei
city: Luoyang
country: China
facility: The First Affiliated Hospital of Henan University of Science &Technology
state: Henan
city: Changsha
country: China
facility: Xiangya Hospital Central South University
state: Hunan
city: Nanjing
country: China
facility: Nanjing Brain Hospital
state: Jiangsu
city: Nanjing
country: China
facility: Sir Run Run Hospital of Nanjing Medical University
state: Jiangsu
city: Suzhou
country: China
facility: The Second Affiliated Hospital of Soochow University
state: Jiangsu
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical College
state: Jiangsu
city: Xuzhou
country: China
facility: Xuzhou Central Hospital
state: Jiangsu
city: Nanchang
country: China
facility: The Second Affiliated Hospital of Nanchang University
state: Jiangxi
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University
state: Jiangxi
city: Changchun
country: China
facility: The First Hospital of Jilin University
state: Jilin
city: Xi'an
country: China
facility: The First Affiliated Hospital of Xi'an Medical University
state: Shaanxi
city: Xianyang
country: China
facility: Xianyang Hospital of Yan'an University
state: Shaanxi
city: Xian
country: China
facility: Shaanxi provincial people's hospital
state: Shaanxi
city: Jinan
country: China
facility: Jinan Central Hospital
state: Shandong
city: Shanghai
country: China
facility: Shanghai Sixth People's Hospital
state: Shanghai
city: Shanghai
country: China
facility: Huashan Hospital, Fudan University
state: Shanghai
city: Shanghai
country: China
facility: Renji Hospital Shanghai Jiao Tong University School of Medicine
state: Shanghai
city: Shanghai
country: China
facility: Pudong New Area People's Hospital Shanghai
state: Shanghai
city: Chengdu
country: China
facility: Sichuan Provincial People's Hospital
state: Sichuan
city: Zigong
country: China
facility: Zigong First People's Hospital
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
state: Tianjin
city: Obu
country: Japan
facility: National Center for Geriatrics and Gerontology
state: Aichi
city: Imabari
country: Japan
facility: Saiseikai Imabari Hospital
state: Ehime
city: Himeji
country: Japan
facility: Hyogo Prefectural Harima-Himeji General Medical Center
state: Hyogo
city: Kobe
country: Japan
facility: Kobe University Hospital
state: Hyogo
city: Fujisawa
country: Japan
facility: Kawashima Neurology Clinic
state: Kanagawa
city: Suita-shi
country: Japan
facility: Medical Corporation Heishinkai OCROM Clinic
state: Osaka
city: Takatsuki-shi
country: Japan
facility: Takatsuki Hospital
state: Osaka
city: Wako
country: Japan
facility: Wako Hospital
state: Saitama
city: Bunkyo-ku
country: Japan
facility: The University of Tokyo Hospital
state: Tokyo
city: Chuo-ku
country: Japan
facility: Medical Corporation Chiseikai Tokyo Center Clinic
state: Tokyo
city: Chuo-ku
country: Japan
facility: Tokyo-Eki Center-building Clinic
state: Tokyo
city: Chuo-ku
country: Japan
facility: Fukuwa Clinic
state: Tokyo
city: Chuo-ku
country: Japan
facility: Tokyo Asbo Clinic
state: Tokyo
city: Hachioji
country: Japan
facility: P-One Clinic
state: Tokyo
city: Itabashi
country: Japan
facility: Tokyo Metropolitan Geriatric Hospital
state: Tokyo
city: Kodaira
country: Japan
facility: Showa General Hospital
state: Tokyo
city: Minato-ku
country: Japan
facility: Sakurazaka Clinic SophyAnce
state: Tokyo
city: Setagaya-ku
country: Japan
facility: Kanto Central Hospital
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Clinical Research Hospital Tokyo
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Heishinkai Medical Group ToCROM Clinic
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Higashi Shinjuku Clinic
state: Tokyo
city: Shinjuku
country: Japan
facility: Samoncho Clinic
state: Tokyo
city: Tachikawa
country: Japan
facility: Tachikawa Hospital
state: Tokyo
city: Fukuoka
country: Japan
facility: UNB Sumiyoshi Jinjamae Clinic
city: Fukuoka
country: Japan
facility: Boocs Clinic Fukuoka
city: Kyoto
country: Japan
facility: Tatsuoka Neurology Clinic
city: Osaka
country: Japan
facility: Iwata Neurosurgery Clinic
city: Cheongju-si
country: Korea, Republic of
facility: Chungbuk National University Hospital
state: Chungcheongbuk-do [Chungbuk]
city: Incheon
country: Korea, Republic of
facility: Inha University Hospital
state: Incheon-gwangyeoksi [Incheon]
city: Namdong-gu
country: Korea, Republic of
facility: Gachon University Gil Medical Center
state: Incheon-gwangyeoksi [Incheon]
city: Jeju-si
country: Korea, Republic of
facility: Jeju National University Hospital
state: Jeju-teukbyeoljachido [Jeju]
city: Wonju
country: Korea, Republic of
facility: Wonju Severance Christian Hospital
state: Kang-won-do
city: Gwangju-si
country: Korea, Republic of
facility: Chonnam National University Hospital
state: Kwangju-Kwangyǒkshi
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Kyǒnggi-do
city: Suwon
country: Korea, Republic of
facility: Ajou University Hospital
state: Kyǒnggi-do
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital
state: Pusan-Kwangyǒkshi
city: Gangnam-gu
country: Korea, Republic of
facility: Gangnam Severance Hospital, Yonsei University Health System
state: Seoul-teukbyeolsi [Seoul]
city: Gangseo-gu
country: Korea, Republic of
facility: Ewha Womans University Seoul Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Hanyang University Seoul Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: The Catholic Univ. of Korea Seoul St. Mary's Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Bayamon
country: Puerto Rico
facility: SCB Research Center
city: San Juan
country: Puerto Rico
facility: Caribbean Medical Research Center
city: San Juan
country: Puerto Rico
facility: INSPIRA Clinical Research
city: San Juan
country: Puerto Rico
facility: Instituto De Neurologia Dra. Ivonne Fraga
city: Seville
country: Spain
facility: Hospital Victoria Eugenia
state: Andalucía
city: Barcelona
country: Spain
facility: Barcelonabeta Brain Research Center
state: Barcelona [Barcelona]
city: Barcelona
country: Spain
facility: Fundació ACE
state: Barcelona [Barcelona]
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
state: Catalunya [Cataluña]
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
state: Catalunya [Cataluña]
city: Pozuelo de Alarcon
country: Spain
facility: Hospital Universitario Quironsalud Madrid
state: Madrid
city: San Sebastián
country: Spain
facility: Policlinica Gipuzkoa
state: País Vasco
city: Changhua County
country: Taiwan
facility: Changhua Christian Hospital
state: Changhua
city: Kaohsiung Niao Sung Dist
country: Taiwan
facility: Chang Gung Memorial Hospital at Kaohsiung
state: Kaohsiung
city: New Taipei City
country: Taiwan
facility: Far Eastern Memorial Hospital
state: New Taipei
city: New Taipei City
country: Taiwan
facility: Cardinal Tien Hospital
state: New Taipei
city: New Taipei City
country: Taiwan
facility: New Taipei Municipal TuCheng Hospital
state: New Taipei
city: Douliu City
country: Taiwan
facility: National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region
state: Yunlin
city: New Taipei
country: Taiwan
facility: Taipei Medical University Shuang Ho Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation-Linkou Branch
city: Bath
country: United Kingdom
facility: ReMind UK
state: Bath And North East Somerset
city: Redruth
country: United Kingdom
facility: Homecroft Surgery
state: Cornwall
city: Plymouth
country: United Kingdom
facility: Roborough Surgery
state: Devon
city: Edinburgh
country: United Kingdom
facility: Scottish Brain Sciences
state: Edinburgh, City Of
city: Romsey
country: United Kingdom
facility: Abbeywell Surgery
state: England
city: Motherwell
country: United Kingdom
facility: NeuroClin
state: Great Britain
city: Southampton
country: United Kingdom
facility: Moorgreen Hospital
state: Hampshire
city: Blackpool
country: United Kingdom
facility: Layton Medical Centre
state: Lancashire
city: London
country: United Kingdom
facility: St Pancras Clinical Research
state: London, City Of
city: Oxford
country: United Kingdom
facility: Warneford Hospital
state: Oxfordshire
city: West Kirby
country: United Kingdom
facility: Marine Lake Medical Practice
state: Wirral
city: Birmingham
country: United Kingdom
facility: Re:Cognition Health - Birmingham
city: Manchester
country: United Kingdom
facility: NIHR Manchester Clinical Research Facility
Study officials:
affiliation: Eli Lilly and Company
name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
role: STUDY_DIRECTOR
References: