Clinical trial NCT03450824: Relationship Between Constitutional Varus Knee and Patellofemoral Pain
Official title: Research on the Relationship Between Constitutional Varus Knee and Patellofemoral Pain
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Patellofemoral Pain Syndrome
Keywords: Patellofemoral Pain Syndrome
Anterior Knee Pain
Knee Varus
Lead sponsor: 113th Hospital of Chinese People's Liberation Army
Sponsor class: OTHER
Collaborators: name: Air Force Military Medical University, China
First posted: 2018-03-01
Enrollment: 21
Sex: ALL
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Military personnel. Running at least 10 km per week for at least 3 months.

Brief summary: This study aims to research on the relationship between constitutional varus knee and patellofemoral pain. The standardized standing whole-lower-extremity radiographs, the knee lateral view and skyline view of the participants will be taken. The hip-knee-ankle angle will be obtained from the radiographs. According to the hip-knee-ankle angle, the knees will be labelled knee varus or knee nonvarus. The knee varus incidences of the two groups will be determined and compared.

Detailed description: The patellofemoral joint will be assessed in the skyline view and lateral view. The hip-knee-ankle angle will be obtained from the standing whole-lower-extremity radiographs. According to the hip-knee-ankle angle, the knees will be labelled knee varus or knee nonvarus. The knee varus incidences of the two groups will be determined and compared. It is hypothesized that constitutional varus knee is a risk factor for patellofemoral pain.

Eligibility criteria: Inclusion Criteria:

* Patellofemoral pain during physical activities such as running, jumping, squatting, and going up or down stairs for at least 4 weeks.
* The onset of pain is required to be atraumatic in nature.
* Exhibit two of the following clinical criteria on assessment: pain on direct compression of the patella against the femoral condyles with the knee in full extension, tenderness of the posterior surface of the patell on palpation, pain on resisted knee extension, and pain with isometric quadriceps muscle contraction against suprapatellar resistance with the knee in 15° of flexion.
* Negative findings in the examination of knee ligaments, menisci, bursae, synovial plicae, Hoffa's fat pad, iliotibial band, and the hamstring, quadriceps, and patellar tendons and their insertions.

Exclusion Criteria:

* With patellofemoral instability, or With other knee diagnoses.
* Any previous surgery or severe trauma in the affected limb.
* Inflammatory joint disease or tumors in the affected limb.

Primary outcomes:
measure: The hip-knee-ankle angle
timeFrame: 1 day
Secondary outcomes:
measure: Patellar alignment
timeFrame: 1 day
measure: The width of of the patellofemoral joint space
timeFrame: 1 day
measure: Trochlear morphology
timeFrame: 1 day
measure: Patellar height
timeFrame: 1 day
Other outcomes:
Locations:
city: Ningbo
country: China
facility: Orthopaedics clinic, No.113 Hospital of Chinese People's Liberation Army
state: Zhejiang
Study officials:
affiliation: Department of orthopaedics, Xijing hospital, Fourth Military Medical University, Xi'an, China
name: Qingsheng Zhu, MD
role: STUDY_DIRECTOR
References: