Clinical trial NCT02042963: KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation (KNOW-KT)
Official title: KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation : A 9-year Longitudinal Cohort Study of the Kidney Transplantation (KNOW-KT)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Kidney Transplant Recipients
Complications After Kidney Transplant
Keywords: The cohort of Asian kidney transplant recipients
The cohort of metabolic complication after kidney transplant
The biorepository of Asian kidney transplant recipients
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: Asan Medical Center
name: Chonbuk National University Medical School
name: Gachon University Gil Medical Center
name: Keimyung University Dongsan Medical Center
name: Korea University
name: Kyungpook National University Hospital
name: Samsung Medical Center
name: Medical Research Collaborating Center, Seoul, Korea
name: Yonsei University
name: Seoul National University College of Medicine
First posted: 2014-01-23
Enrollment: 1000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Kidney transplant recipients and their donors (donors for baseline data)

Brief summary: KNOW-KT (KoreaN cohort study for Outcome in patients With KT: A 9-year Longitudinal cohort study of the Korean adult KT patients), funded by Korea Center for Disease Control and Prevention (KCDC) was established in 2012 by a group of transplant physicians, transplant surgeons, nephrologists, epidemiologists, and biostatisticians in Korea.

We aimed to establish an adult KT cohort, to investigate the renal allograft outcomes, mortality, complications, and to explore traditional or nontraditional risk factors for morbidity and mortality. We established a bio-bank to integrate clinical and biological information. Here, we report design and method of the KNOW-KT.


Eligibility criteria: Inclusion Criteria:

* Recipients and Donors of kidney transplant

Exclusion Criteria:

* Multi-organ transplant recipients

Primary outcomes:
measure: overall mortality
timeFrame: 9 years
measure: Allograft survival
timeFrame: 9 years
Secondary outcomes:
measure: cardiovascular event
timeFrame: 9 years
measure: Albuminuria
timeFrame: 9 years
measure: Acute Rejection
timeFrame: 9 years
measure: New onset of diabetes after transplant
timeFrame: 9 years
measure: Quality of Life
timeFrame: 2 years
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National Univeristy Hospital
Study officials:
References:
citation: Jung HY, Jeon Y, Huh KH, Park JB, Kim MG, Lee S, Han S, Ro H, Yang J, Ahn C, Cho JH, Park SH, Kim YL, Kim CD. Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study. Transpl Int. 2022 May 30;35:10243. doi: 10.3389/ti.2022.10243. eCollection 2022.
citation: Hong N, Lee J, Kim HW, Jeong JJ, Huh KH, Rhee Y. Machine Learning-Derived Integer-Based Score and Prediction of Tertiary Hyperparathyroidism among Kidney Transplant Recipients: An Integer-Based Score to Predict Tertiary Hyperparathyroidism. Clin J Am Soc Nephrol. 2022 Jul;17(7):1026-1035. doi: 10.2215/CJN.15921221. Epub 2022 Jun 10.
citation: Yang J, Lee J, Huh KH, Park JB, Cho JH, Lee S, Ro H, Han SY, Kim YH, Jeong JC, Park BJ, Han DJ, Park SB, Chung W, Park SK, Kim CD, Kim SJ, Kim YS, Ahn C; KNOW-KT Study Group. KNOW-KT (KoreaN cohort study for outcome in patients with kidney transplantation: a 9-year longitudinal cohort study): study rationale and methodology. BMC Nephrol. 2014 May 9;15:77. doi: 10.1186/1471-2369-15-77.