Clinical trial NCT02800122: PAthwAy of Dyspneic patIent in Emergency (PArADIsE)
Official title: PAthwAy of Dyspneic patIent in Emergency
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Dyspnea; Cardiac
Acute Disease
Keywords: acute dyspnea
emergency
acute heart failure
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
Collaborators: name: Central Hospital, Nancy, France
First posted: 2016-06-15
Enrollment: 24000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with acute dyspnea cared by a medical team of emergencies of CHRU Nancy in the last 5 years.

Brief summary: This is an observational retrospective single-center study (CHRU of Nancy) in patients cared for acute dyspnea by a medical team of the emergencies of the CHRU of Nancy.

The main purpose of the study is to evaluate the outcome of patients cared for acute dyspnea by a medical team of emergencies of CHRU of Nancy.

Detailed description: This observational retrospective single-center study will be conducted using data from medical records, acquired as part of usual care, patients cared for acute dyspnea in the last 5 years (from the date of authorization of data processing). About 4,000 patients will be affected, including more than 800 patients with acute heart failure.

Eligibility criteria: Inclusion Criteria:

* Man or women ≥ 18 years
* Patients with acute dyspnea cared by a medical team of the emergencies of CHRU of Nancy.

Exclusion Criteria:

* Cardiorespiratory arrest before the care by a medical team of the emergencies of the CHRU of Nancy.

Primary outcomes:
measure: All cause in-hospital mortality
timeFrame: in the last 5 years
Secondary outcomes:
measure: Demographic and clinical data of patients cared by a medical team of emergencies
timeFrame: in the last 5 years
measure: Duration of total hospitalization (including emergency stay and conventional hospitalization)
timeFrame: in the last 5 years
measure: The main diagnosis of the initial hospitalization
timeFrame: in the last 5 years
measure: Rate of Brain Natriuretic Peptide (BNP)
timeFrame: in the last 5 years
measure: Administration of non-invasive ventilation and / or diuretics and / or nitrates
timeFrame: in the last 5 years
measure: Administration time of non-invasive ventilation and / or diuretics and / or nitrates
timeFrame: in the last 5 years
measure: Service type admitting the patient after the emergency care (intensive care, cardiology, intensive care cardiology, other ...)
timeFrame: in the last 5 years
measure: Admission time in a service after the emergency care
timeFrame: in the last 5 years
measure: Mortality and re-hospitalization of included patients
timeFrame: in the last 5 years
Other outcomes:
Locations:
city: Nancy
country: France
facility: CHRU Nancy - Service des Urgences
Study officials:
affiliation: Central Hospital, Nancy, France
name: Tahar CHOUIHED, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Central Hospital, Nancy, France
name: Nicolas GIRERD, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chouihed T, Bassand A, Duarte K, Jaeger D, Roth Y, Giacomin G, Delaruelle A, Duchanois C, Bannay A, Kobayashi M, Rossignol P, Girerd N. Head-to-head comparison of diagnostic scores for acute heart failure in the emergency department: results from the PARADISE cohort. Intern Emerg Med. 2022 Jun;17(4):1155-1163. doi: 10.1007/s11739-021-02879-6. Epub 2021 Nov 17.
citation: Chouihed T, Buessler A, Bassand A, Jaeger D, Virion JM, Nace L, Barbe F, Salignac S, Rossignol P, Zannad F, Girerd N. Hyponatraemia, hyperglycaemia and worsening renal function at first blood sample on emergency department admission as predictors of in-hospital death in patients with dyspnoea with suspected acute heart failure: retrospective observational analysis of the PARADISE cohort. BMJ Open. 2018 Mar 30;8(3):e019557. doi: 10.1136/bmjopen-2017-019557.