Clinical trial NCT05601882: A Study to Evaluate Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
Official title: A Phase 3b/4 Randomized, Open-label, Efficacy Assessor Blinded Study, Comparing the Safety and Assessor Blinded Efficacy of Upadacitinib to Dupilumab in Subjects With Moderate to Severe Atopic Dermatitis (Level-Up)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Atopic Dermatitis
Keywords: Atopic Dermatitis
AD
Level-Up
Upadacitinib
Dupilumab
RINVOQ
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2022-11-01
Enrollment: 920
Sex: ALL
Minimum age (years): 12
Maximum age (years): 64
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment. This study compares upadacitinib to dupilumab in adolescent and adult participants with moderate to severe AD who have inadequate response to systemic therapies. Adverse events and change in the disease activity will be assessed.

Upadacitinib and dupilumab are approved drugs for the treatment of moderate to severe atopic dermatitis (AD). The study is comprised of a 35-day Screening Period, a 16-week treatment Period 1 and a 16-week treatment Period 2. Participants are randomly assigned to 1 of 2 groups called treatment arms to receive upadacitinib Dose A or dupilumab in Period 1. There is a 30-day or 12-week follow-up visit for those on upadacitinib or dupilumab respectively, who will not enter Period 2. In Period 2, participants will receive upadacitinib Dose A or Dose B for 16 weeks, followed by a 30-day follow-up visit. Approximately 880 adolescent and adult participants ages 12 to 64 with moderate to severe AD who are candidates for systemic therapy will be enrolled at up to 330 sites worldwide.

There may be higher treatment burden for participants in this trial compared to their standard of care . Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.


Eligibility criteria: Inclusion Criteria:

* Chronic atopic dermatitis (AD) with onset of symptoms at least 3 years prior to baseline and participant meets Hanifin and Rajka criteria.
* Eczema area and severity index (EASI) score ≥ 16;validated Investigator´s Global Assessment for AD (vIGA-AD) score ≥ 3 and ≥ 10% Body Surface Area Involvement of Atopic Dermatitis (BSA of AD) involvement at the Baseline Visit.
* Baseline weekly average of daily Worst Pruritus Numerical Rating Scale (WP-NRS) ≥ 4.
* Documented history of inadequate response to previous systemic treatment defined as documented history of previous inadequate response to at least one prior systemic treatment for AD OR for whom other systemic treatments are otherwise medically inadvisable.

Exclusion Criteria:

* History of clinically significant (per investigator's judgment) drug or alcohol abuse within the last 6 months.
* History of an organ transplant which requires continued immunosuppression.

Primary outcomes:
measure: Percentage of Participants Achieving a ≥ 90% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 90) and Worst Pruritus Numerical Rating Scale of 0 or 1 (WP-NRS 0/1) at Week 16
timeFrame: Baseline and Week 16
Secondary outcomes:
measure: Percentage of Participants Achieving a ≥ 90% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 90) at Week 16
timeFrame: Baseline and Week 16
measure: Percentage of Participants Achieving a Worst Pruritus Numerical Rating Scale of 0 or 1 (WP-NRS 0/1) at Week 16 Among Participants With Baseline WP-NRS > 1
timeFrame: Baseline and Week 16
measure: Percentage of Participants Achieving an Improvement (Reduction) in Worst Pruritus Numerical Rating Scale (WP-NRS) ≥ 4 at Week 16 Among Those With Baseline WP-NRS ≥ 4
timeFrame: Baseline and Week 16
measure: Percentage of Participants Achieving a Worst Pruritus Numerical Rating Scale of 0 or 1 (WP-NRS 0/1) at Week 4 Among Participants With Baseline WP-NRS > 1
timeFrame: Baseline and Week 4
measure: Percentage of Participants Achieving a Worst Pruritus Numerical Rating Scale of 0 or 1 (WP-NRS 0/1) at Week 2 Among Participants With Baseline WP-NRS > 1
timeFrame: Baseline and Week 2
measure: Percentage of Participants Achieving a ≥ 90% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 90) at Week 4
timeFrame: Baseline and Week 4
measure: Percentage of Participants Achieving a ≥ 75% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 75) at Week 2
timeFrame: Baseline and Week 2
measure: Percentage of Participants Achieving a 100% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 100) at Week 16
timeFrame: Baseline and Week 16
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Medical Dermatology Specialists /ID# 250212
state: Arizona
city: Phoenix
country: United States
facility: Alliance Dermatology and Mohs Center /ID# 249671
state: Arizona
city: Fayetteville
country: United States
facility: Clinical Trials Institute - Northwest Arkansas /ID# 249838
state: Arkansas
city: North Little Rock
country: United States
facility: Arkansas Research Trials /ID# 250722
state: Arkansas
city: Encino
country: United States
facility: Joseph Raoof Md,Inc /Id# 250211
state: California
city: Fountain Valley
country: United States
facility: First OC Dermatology /ID# 250686
state: California
city: Lancaster
country: United States
facility: Antelope Valley Clinical Trials /ID# 249946
state: California
city: Los Angeles
country: United States
facility: Dermatology Research Associates /ID# 249829
state: California
city: Sacramento
country: United States
facility: University of California Davis Health /ID# 250044
state: California
city: Thousand Oaks
country: United States
facility: Clinical Trials Research Institute /ID# 250213
state: California
city: Wheat Ridge
country: United States
facility: Western States Clinical Res /ID# 250274
state: Colorado
city: Farmington
country: United States
facility: UConn Health /ID# 253807
state: Connecticut
city: New Haven
country: United States
facility: Yale Center for Clinical Investigation /ID# 254791
state: Connecticut
city: Boca Raton
country: United States
facility: Clearlyderm Dermatology /ID# 250457
state: Florida
city: Boca Raton
country: United States
facility: Skin Care Research Boca Raton /ID# 250458
state: Florida
city: Clearwater
country: United States
facility: Olympian Clinical Research /ID# 250453
state: Florida
city: Hollywood
country: United States
facility: Skin Care Research - Hollywood /ID# 250459
state: Florida
city: Jacksonville
country: United States
facility: Solutions Through Adv Rch /ID# 250455
state: Florida
city: Margate
country: United States
facility: GSI Clinical Research, LLC /ID# 250768
state: Florida
city: Miami Lakes
country: United States
facility: Wellness Clinical Research - Miami Lakes /ID# 250236
state: Florida
city: Miami
country: United States
facility: D&H National Research Centers /ID# 250734
state: Florida
city: Miami
country: United States
facility: Florida International Rsrch cr /ID# 249667
state: Florida
city: North Miami Beach
country: United States
facility: Tory P Sullivan, MD PA /ID# 251136
state: Florida
city: Sunrise
country: United States
facility: Precision Clinical Research /ID# 250990
state: Florida
city: Tampa
country: United States
facility: Advanced Clinical Research Institute /ID# 250460
state: Florida
city: West Palm Beach
country: United States
facility: Metabolic Research Inst /ID# 250046
state: Florida
city: Boise
country: United States
facility: Treasure Valley Medical Research /ID# 250727
state: Idaho
city: Indianapolis
country: United States
facility: Dawes Fretzin, LLC /ID# 250276
state: Indiana
city: West Lafayette
country: United States
facility: Randall Dermatology of West Lafayette /ID# 250234
state: Indiana
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center /ID# 251212
state: Massachusetts
city: Quincy
country: United States
facility: Beacon Clinical Research, LLC /ID# 251412
state: Massachusetts
city: Clarkston
country: United States
facility: Clarkston Dermatology /ID# 250225
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Medical Center - New Center One /ID# 250228
state: Michigan
city: Kirksville
country: United States
facility: Cleaver Dermatology /ID# 250725
state: Missouri
city: Saint Joseph
country: United States
facility: MediSearch Clinical Trials /ID# 250272
state: Missouri
city: Lincoln
country: United States
facility: Duplicate_Allergy, Asthma & Immunology Associates, PC /ID# 250616
state: Nebraska
city: Lincoln
country: United States
facility: Physician Research Collaboration, LLC /ID# 251099
state: Nebraska
city: Bronx
country: United States
facility: Montefiore Medical Center - Moses Campus /ID# 251214
state: New York
city: Bexley
country: United States
facility: Derm of Greater Columbus /ID# 250049
state: Ohio
city: Cleveland
country: United States
facility: Univ Hosp Cleveland /ID# 250699
state: Ohio
city: Fairborn
country: United States
facility: Wright State Physicians - Fairborn /ID# 254167
state: Ohio
city: Tulsa
country: United States
facility: Vital Prospects Clinical Research Institute, PC /ID# 249840
state: Oklahoma
city: Portland
country: United States
facility: Oregon Dermatology and Research Center /ID# 250726
state: Oregon
city: Portland
country: United States
facility: Oregon Medical Research Center /ID# 249666
state: Oregon
city: Portland
country: United States
facility: Oregon Medical Research Center /ID# 250712
state: Oregon
city: Pittsburgh
country: United States
facility: University of Pittsburgh MC /ID# 251208
state: Pennsylvania
city: Charleston
country: United States
facility: Duplicate_Medical University of South Carolina /ID# 251218
state: South Carolina
city: Rapid City
country: United States
facility: Health Concepts /ID# 250988
state: South Dakota
city: Murfreesboro
country: United States
facility: International Clinical Research - Tennessee LLC /ID# 250724
state: Tennessee
city: Arlington
country: United States
facility: Arlington Research Center, Inc /ID# 250468
state: Texas
city: Austin
country: United States
facility: Orion Clinical Research /ID# 250473
state: Texas
city: Bellaire
country: United States
facility: Bellaire Dermatology Associates /ID# 250739
state: Texas
city: Dallas
country: United States
facility: Modern Research Associates, PLLC /ID# 250688
state: Texas
city: Houston
country: United States
facility: Center for Clinical Studies - Houston - Northwest Freeway /ID# 250039
state: Texas
city: San Antonio
country: United States
facility: Texas Dermatology and Laser Specialists /ID# 250367
state: Texas
city: Murray
country: United States
facility: University of Utah /ID# 250042
state: Utah
city: Charlottesville
country: United States
facility: University of Virginia - Dermatology /ID# 254166
state: Virginia
city: Norfolk
country: United States
facility: Virginia Clinical Research, Inc. /ID# 249908
state: Virginia
city: Kogarah
country: Australia
facility: Premier Specialist /ID# 250572
state: New South Wales
city: Woolloongabba
country: Australia
facility: Veracity Clinical Research /ID# 249943
state: Queensland
city: Carlton
country: Australia
facility: Skin Health Institute Inc /ID# 249938
state: Victoria
city: East Melbourne
country: Australia
facility: Sinclair Dermatology - Melbourne /ID# 249937
state: Victoria
city: Fremantle
country: Australia
facility: Fremantle Dermatology /ID# 249941
state: Western Australia
city: Woluwe-Saint-Lambert
country: Belgium
facility: Cliniques Universitaires UCL Saint-Luc /ID# 251403
state: Bruxelles-Capitale
city: Charleroi
country: Belgium
facility: Grand Hopital de Charleroi /ID# 251401
state: Hainaut
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven /ID# 251399
state: Vlaams-Brabant
city: Liege
country: Belgium
facility: CHU de Liege /ID# 251400
city: Pleven
country: Bulgaria
facility: UMHAT Dr Georgi Stranski EAD /ID# 251268
state: Smolyan
city: Sofiya
country: Bulgaria
facility: Diagnostic Consultative Center Aleksandrovska /ID# 251137
state: Sofia
city: Plovdiv
country: Bulgaria
facility: DCC Pulmed AD /ID# 251271
city: Sofia
country: Bulgaria
facility: Ambulatory for Specialized Medical Care for skin and venereal diseases /ID# 251272
city: Sofia
country: Bulgaria
facility: Medical center EuroHealth /ID# 251270
city: Sofia
country: Bulgaria
facility: Military Medical Academy Multiprofile Hospital /ID# 251187
city: Sofiya
country: Bulgaria
facility: Diagnostic consultative center Focus-5 /ID# 251269
city: Sofiya
country: Bulgaria
facility: Medical Center Euroderma /ID# 251267
city: Stara Zagora
country: Bulgaria
facility: MC Zara-Med EOOD /ID# 251135
city: Calgary
country: Canada
facility: Dermatology Research Institute - Blackfoot Trail /ID# 251642
state: Alberta
city: Calgary
country: Canada
facility: Beacon Dermatology Inc /ID# 250336
state: Alberta
city: Edmonton
country: Canada
facility: Alberta DermaSurgery Centre /ID# 250217
state: Alberta
city: Surrey
country: Canada
facility: Dr. Chih-ho Hong Medical Inc. /ID# 251643
state: British Columbia
city: Surrey
country: Canada
facility: Enverus Medical Research /ID# 251645
state: British Columbia
city: Winnipeg
country: Canada
facility: Wiseman Dermatology Research /ID# 250219
state: Manitoba
city: Fredericton
country: Canada
facility: Brunswick Dermatology Center /ID# 250220
state: New Brunswick
city: Hamilton
country: Canada
facility: LEADER Research /ID# 251647
state: Ontario
city: London
country: Canada
facility: DermEffects /ID# 250223
state: Ontario
city: Markham
country: Canada
facility: Lynde Institute for Dermatology /ID# 251854
state: Ontario
city: Mississauga
country: Canada
facility: DermEdge Research Inc. /ID# 250216
state: Ontario
city: Peterborough
country: Canada
facility: SKiN Centre for Dermatology /ID# 251853
state: Ontario
city: Toronto
country: Canada
facility: Toronto Dermatology Centre /ID# 252098
state: Ontario
city: Toronto
country: Canada
facility: Research Toronto /ID# 250222
state: Ontario
city: Waterloo
country: Canada
facility: Private Practice - Dr. Kim Papp Clinical Research /ID# 251644
state: Ontario
city: Québec
country: Canada
facility: Centre de Recherche dermatologique du Quebec Metropolitain /ID# 250427
state: Quebec
city: Fuzhou
country: China
facility: The First Affiliated Hospital Of Fujian Medical University /ID# 249674
state: Fujian
city: Guangzhou
country: China
facility: Dermatology Hospital of Southern Medical University /ID# 250121
state: Guangdong
city: Guangzhou
country: China
facility: Guangzhou First People's Hospital /ID# 249695
state: Guangdong
city: Guangzhou
country: China
facility: The Second Affiliated Hospital of Guangzhou Medical University /ID# 249694
state: Guangdong
city: Shenzhen
country: China
facility: The University of Hong Kong- Shenzhen Hospital /ID# 249436
state: Guangdong
city: Changsha
country: China
facility: The Second Xiangya Hospital of Central South University /ID# 249657
state: Guizhou
city: Wuhan
country: China
facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 251485
state: Hubei
city: Shenyang
country: China
facility: The First Hospital of China Medical University /ID# 249638
state: Liaoning
city: Shanghai
country: China
facility: Huashan Hospital, Fudan University /ID# 250025
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Skin Disease Hospital /ID# 249392
state: Shanghai
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital /ID# 250246
state: Tianjin
city: Hangzhou
country: China
facility: Hangzhou First People's Hospital /ID# 249437
state: Zhejiang
city: Hangzhou
country: China
facility: The second affiliated hospital of Zhejiang University school of medicine /ID# 249655
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Provincial People's Hospital /ID# 249653
state: Zhejiang
city: Zagreb
country: Croatia
facility: DermaPlus - Poliklinika za dermatologiju i venerologiju /ID# 249591
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Djecja bolnica Srebrnjak /ID# 249594
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Zagreb /ID# 249596
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinika za dječje bolesti Zagreb /ID# 249590
state: Grad Zagreb
city: Rijeka
country: Croatia
facility: Klinicki bolnicki centar Rijeka /ID# 249593
state: Primorsko-goranska Zupanija
city: Split
country: Croatia
facility: Klinicki Bolnicki Centar (KBC) Split /ID# 249879
state: Splitsko-dalmatinska Zupanija
city: Grad Zagreb
country: Croatia
facility: Poliklinika Solmed /ID# 252138
city: Copenhagen NV
country: Denmark
facility: Bispebjerg and Frederiksberg Hospital /ID# 248902
state: Hovedstaden
city: Hellerup
country: Denmark
facility: Herlev and Gentofte Hospital /ID# 248900
state: Hovedstaden
city: Aarhus
country: Denmark
facility: Aarhus Universitetshospital - Skejby /ID# 248899
state: Midtjylland
city: Roskilde
country: Denmark
facility: Roskilde Sygehus /ID# 248901
state: Sjælland
city: Marseille
country: France
facility: Hopital Saint Joseph /ID# 251053
state: Bouches-du-Rhone
city: Nantes
country: France
facility: CHU de Nantes, Hotel Dieu -HME /ID# 251347
state: Pays-de-la-Loire
city: Pierre Benite CEDEX
country: France
facility: HCL - Hopital Lyon Sud /ID# 251343
state: Rhone
city: Paris
country: France
facility: Hôpital Saint-Louis /ID# 251052
city: Rouen
country: France
facility: Hôpital Charles-Nicolle /ID# 251055
city: Toulouse
country: France
facility: CHU Toulouse - Hopital Larrey /ID# 251344
city: Freiburg
country: Germany
facility: Universitaetsklinikum Freiburg /ID# 249555
state: Baden-Wuerttemberg
city: Heidelberg
country: Germany
facility: Universitaetsklinik Heidelberg /ID# 251458
state: Baden-Wuerttemberg
city: Tubingen
country: Germany
facility: Universitaetsklinikum Tuebingen /ID# 249552
state: Baden-Wuerttemberg
city: Blankenfelde-Mahlow
country: Germany
facility: Dermatologische Gemeinschaftspraxis Mahlow /ID# 250306
state: Brandenburg
city: Darmstadt
country: Germany
facility: Klinikum Darmstadt /ID# 251391
state: Hessen
city: Frankfurt am Main
country: Germany
facility: Universitaetsklinikum Frankfurt /ID# 249544
state: Hessen
city: Bramsche
country: Germany
facility: Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 251392
state: Niedersachsen
city: Bonn
country: Germany
facility: Universitaetsklinikum Bonn /ID# 250307
state: Nordrhein-Westfalen
city: Muenster
country: Germany
facility: Universitaetsklinikum Muenster /ID# 249404
state: Nordrhein-Westfalen
city: Mainz
country: Germany
facility: Universitaetsmedizin Mainz /ID# 249549
state: Rheinland-Pfalz
city: Bad Bentheim
country: Germany
facility: Fachklinik Bad Bentheim /ID# 249545
state: Saarland
city: Leipzig
country: Germany
facility: Universitaetsklinikum Leipzig /ID# 249562
state: Sachsen
city: Lübeck
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 249560
state: Schleswig-Holstein
city: Bochum
country: Germany
facility: Hautarztpraxis Dr. Niesmann und Dr. Othlinghaus /ID# 251566
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 251844
city: Friedrichshafen
country: Germany
facility: Derma Study Center Friedrichshafen GmbH /ID# 251460
city: Hamburg
country: Germany
facility: Universitaetsklinikum Hamburg-Eppendorf /ID# 249547
city: Hamburg
country: Germany
facility: Dermatologikum Hamburg /ID# 251390
city: Munich
country: Germany
facility: Klinikum rechts der Isar /ID# 249548
city: Athens
country: Greece
facility: 401 GSNA - 401 Army General Hospital /ID# 251843
state: Attiki
city: Athens
country: Greece
facility: General Hospital Andreas Syggros /ID# 251842
state: Attiki
city: Thessaloniki
country: Greece
facility: Papageorgiou General Hospital /ID# 251840
state: Evrytania
city: Kecskemet
country: Hungary
facility: Bacs-Kiskun Varmegyei Oktatokorhaz /ID# 249850
state: Bacs-Kiskun
city: Debrecen
country: Hungary
facility: Debreceni Egyetem-Klinikai Kozpont /ID# 249849
state: Hajdu-Bihar
city: Gyongyos
country: Hungary
facility: Gyongyosi Bugat Pal Korhaz /ID# 251367
state: Heves
city: Pecs
country: Hungary
facility: Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 250419
state: Nograd
city: Kaposvár
country: Hungary
facility: Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 249848
state: Somogy
city: Budapest
country: Hungary
facility: Clinexpert Kft /ID# 249822
city: Budapest
country: Hungary
facility: Semmelweis Egyetem /ID# 251368
city: Budapest
country: Hungary
facility: UNO Medical Trials /ID# 249820
city: Debrecen
country: Hungary
facility: DERMA-B Egeszsegugyi es Szolgaltato - Debrecen - Gyepusor Utca /ID# 249819
city: Szeged
country: Hungary
facility: Szegedi Tudományegyetem /ID# 249818
city: Szolnok
country: Hungary
facility: Allergo-Derm Bakos Kft. /ID# 249821
city: Jerusalem
country: Israel
facility: Hadassah Medical Center-Hebrew University /ID# 251576
state: Yerushalayim
city: Haifa
country: Israel
facility: Rabin Medical Center /ID# 251578
city: Chieti
country: Italy
facility: CAST - Center for Advanced Studies and Technology /ID# 251495
state: L Aquila
city: L'Aquila
country: Italy
facility: Presidio Ospedaliero San Salvatore /ID# 250127
state: L Aquila
city: Rozzano
country: Italy
facility: IRCCS Istituto Clinico Humanitas /ID# 251493
state: Milano
city: Rome
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 250125
state: Roma
city: Rome
country: Italy
facility: IRCCS Istituti Fisioterapici Ospitalieri-Istituto Dermatologico San Gallicano /ID# 250558
state: Roma
city: Rome
country: Italy
facility: Policlinico Agostino Gemelli /ID# 251494
state: Roma
city: Brescia
country: Italy
facility: ASST degli Spedali Civili di Brescia /ID# 250129
city: Florence
country: Italy
facility: Ospedale Piero Palagi /ID# 250206
city: Milano
country: Italy
facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 250123
city: Modena
country: Italy
facility: Azienda Ospedaliero-Universitaria di Modena /ID# 250128
city: Perugia
country: Italy
facility: Azienda Ospedaliera di Perugia - Ospedale S. Maria della Misericordia /ID# 251572
city: Pisa
country: Italy
facility: Azienda Ospedaliero Universitaria Pisana /ID# 250124
city: Sapporo-shi
country: Japan
facility: Medical Corporation Kojinkai Sapporo Skin Clinic /ID# 252549
state: Hokkaido
city: Kawasaki-shi
country: Japan
facility: Medical corporation Kojunkai Kosugi Dermatology Clinic /ID# 252554
state: Kanagawa
city: Sagamihara-shi
country: Japan
facility: National Hospital Organization Sagamihara National Hospital /ID# 254518
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Queen's Square Medical Center, Dermatology and Allergology /ID# 252551
state: Kanagawa
city: Habikino-shi
country: Japan
facility: Osaka Habikino Medical Center /ID# 252550
state: Osaka
city: Sakai-shi
country: Japan
facility: Dermatology and Ophthalmology Kume Clinic /ID# 254570
state: Osaka
city: Setagaya-ku
country: Japan
facility: Naoko Dermatology Clinic /ID# 254571
state: Tokyo
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital /ID# 249852
state: Busan Gwang Yeogsi
city: 중구
country: Korea, Republic of
facility: Kyungpook National University Hospital /ID# 249855
state: Daegu Gwang Yeogsi
city: Ansan-si
country: Korea, Republic of
facility: Korea University Ansan Hospital /ID# 249814
state: Gyeonggido
city: Bucheon-si
country: Korea, Republic of
facility: Soon Chun Hyang University Hospital Bucheon /ID# 249812
state: Gyeonggido
city: Dongjak-gu
country: Korea, Republic of
facility: Chungang University Hospital /ID# 251490
state: Gyeonggido
city: Suwon-si
country: Korea, Republic of
facility: Ajou University Hospital /ID# 251491
state: Gyeonggido
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital /ID# 251492
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center /ID# 249811
state: Seoul Teugbyeolsi
city: Monterrey
country: Mexico
facility: Centro de Dermatologia de Monterrey /ID# 249126
state: Baja California
city: Monterrey
country: Mexico
facility: Eukarya PharmaSite, SC /ID# 249702
state: Nuevo Leon
city: Mexico City
country: Mexico
facility: Cryptex Investigacion Clinica S.A de C.V /ID# 249994
city: Tlalnepantla de Baz
country: Mexico
facility: Clinical Research Institute SC /ID# 249647
city: Veracruz
country: Mexico
facility: Arké Estudios Clinicos Veracruz /ID# 250147
city: Bergen op Zoom
country: Netherlands
facility: Bravis Ziekenhuis /ID# 251395
state: Noord-Brabant
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, locatie AMC /ID# 251397
state: Noord-Holland
city: Torun
country: Poland
facility: MICS Centrum Medyczne Torun /ID# 251433
state: Kujawsko-pomorskie
city: Lodz
country: Poland
facility: Dermed Centrum Medyczne Sp. z o.o /ID# 251429
state: Lodzkie
city: Cracow
country: Poland
facility: Lidia Rajzer - Specjalistyczny Gabinet Dermatologiczno-Kosmetyczny /ID# 252082
state: Malopolskie
city: Krakow
country: Poland
facility: Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o. /ID# 251437
state: Malopolskie
city: Warsaw
country: Poland
facility: Royalderm Agnieszka Nawrocka /ID# 251432
state: Mazowieckie
city: Warszawa
country: Poland
facility: Klinika Ambroziak Sp. z o.o. /ID# 249406
state: Mazowieckie
city: Warszawa
country: Poland
facility: Bodyclinic Sp. z o.o. sp.k. /ID# 249599
state: Mazowieckie
city: Iwonicz-Zdrój
country: Poland
facility: Zespol Naukowo-Leczniczy Iwolang Dermatologiczne Centrum Uzdrowiskowe Sp. z o.o /ID# 249598
state: Podkarpackie
city: Bialystok
country: Poland
facility: INTER CLINIC Piotr Adrian Klimiuk /ID# 251430
state: Podlaskie
city: Gdansk
country: Poland
facility: Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 251431
state: Pomorskie
city: Elblag
country: Poland
facility: Centrum Kliniczno-Badawcze J.Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka /ID# 251438
state: Warminsko-mazurskie
city: Poznan
country: Poland
facility: Solumed Centrum Medyczne /ID# 249641
state: Wielkopolskie
city: Cracow
country: Poland
facility: Centrum Medyczne ALL-MED Badania Kliniczne /ID# 249630
city: Guimarães
country: Portugal
facility: Centro Hospitalar Do Alto Ave - Hospital Senhora Da Oliveira /ID# 249196
state: Braga
city: Lisboa
country: Portugal
facility: Hospital CUF Descobertas /ID# 249193
state: Regiao Autonoma Da Madeira
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 249191
state: Regiao Autonoma Da Madeira
city: Almada
country: Portugal
facility: Hospital Garcia de Orta /ID# 251455
state: Setubal
city: Braga
country: Portugal
facility: 2CA-Braga, Hospital de Braga /ID# 250480
city: Leiria
country: Portugal
facility: Unidade Local de Saude da Regiao de Leiria, EPE /ID# 249194
city: Lisbon
country: Portugal
facility: Centro Hospitalar de Lisboa Central /ID# 249195
city: Matosinhos
country: Portugal
facility: Unidade Local de Saúde de Matosinhos, EPE /ID# 249197
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 249192
city: Caguas
country: Puerto Rico
facility: Dr. Samuel Sanchez PSC /ID# 250389
city: Carolina
country: Puerto Rico
facility: Alma M. Cruz Santana, MD-Private practice /ID# 250393
city: San Juan
country: Puerto Rico
facility: Clinical Research Puerto Rico /ID# 250394
city: San Juan
country: Puerto Rico
facility: GCM Medical Group PSC /ID# 250391
city: Bucharest
country: Romania
facility: Bio Terra Med SRL /ID# 249624
state: Bucuresti
city: Cluj Napoca
country: Romania
facility: Private Practice - Dr. Orasan Remus /ID# 249625
state: Cluj
city: Bratislava
country: Slovakia
facility: Derma therapy spol /ID# 249783
state: Bratislavsky Kraj
city: Bratislava
country: Slovakia
facility: Poliklinika Bezrucova (Cliniq s.r.o.) /ID# 249746
city: Bratislava
country: Slovakia
facility: BeneDerma s.r.o. /ID# 251791
city: Pretoria
country: South Africa
facility: University of Pretoria /ID# 250208
state: Gauteng
city: Pretoria
country: South Africa
facility: About Allergy /ID# 249697
state: Gauteng
city: Durban
country: South Africa
facility: Highway Medical Centre /ID# 250103
state: Kwazulu-Natal
city: CAPE TOWN Milnerton
country: South Africa
facility: Spoke Research Inc /ID# 250091
state: Western Cape
city: Cape Town
country: South Africa
facility: Allergy & Immunology (AIU) /ID# 249619
state: Western Cape
city: Badalona
country: Spain
facility: Hospital Universitario Germans Trias i Pujol /ID# 251523
state: Barcelona
city: Esplugues de Llobregat
country: Spain
facility: Hospital Sant Joan de Deu /ID# 249602
state: Barcelona
city: Bilbao
country: Spain
facility: Hospital Universitario Basurto /ID# 249784
state: Vizcaya
city: Alicante
country: Spain
facility: Hospital General Universitario de Alicante Doctor Balmis /ID# 251517
city: Granada
country: Spain
facility: Hospital Universitario Virgen de las Nieves /ID# 249785
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 251518
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena /ID# 249603
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe /ID# 251524
city: Malmo
country: Sweden
facility: Skane University hospital /ID# 250332
state: Skane Lan
city: Solna
country: Sweden
facility: Karolinska University Hospital Solna /ID# 250328
state: Stockholms Lan
city: Umea
country: Sweden
facility: Norrlands University hospital /ID# 250329
state: Vasterbottens Lan
city: Eskilstuna
country: Sweden
facility: Malarsjukhuset /ID# 251908
city: St. Gallen
country: Switzerland
facility: Kantonsspital St. Gallen /ID# 250606
state: Sankt Gallen
city: Bern
country: Switzerland
facility: Inselspital, Universitaetsspital Bern /ID# 250577
city: Kaohsiung City
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital /ID# 249260
state: Kaohsiung
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital /ID# 249261
state: Keelung
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 249258
state: Taipei
city: Hsinchu City
country: Taiwan
facility: National Taiwan University Hospital - Hsinchu branch /ID# 249265
city: New Taipei City
country: Taiwan
facility: Taipei Medical University Shuang Ho Hospital /ID# 249256
city: Taipei City
country: Taiwan
facility: Mackay Memorial Hospital /ID# 249259
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hosp /ID# 249263
city: Taipei
country: Taiwan
facility: Taipei Municipal Wan Fang Hospital /ID# 251500
city: Taoyuan City
country: Taiwan
facility: Linkou Chang Gung Memorial Hospital /ID# 249257
city: Gaziantep
country: Turkey
facility: Gaziantep Universitesi /ID# 249868
state: Adana
city: Ankara
country: Turkey
facility: Ankara City Hospital /ID# 249870
city: Antalya
country: Turkey
facility: Akdeniz Universitesi Tip Fakul /ID# 249866
city: Bursa
country: Turkey
facility: Uludag University Medical Faculty /ID# 249864
city: Kayseri
country: Turkey
facility: Erciyes University Medical Faculty /ID# 249863
city: Samsun
country: Turkey
facility: Ondokuz Mayis Universitesi /ID# 249865
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: