Clinical trial NCT06291935: Safety and Tolerability of Intravitreal Administration of VG901 in Patients With Retinitis Pigmentosa Due to Mutations in the CNGA1 Gene
Official title: A Prospective, Open-label, Phase 1b, Single-arm, Safety Study of an Intravitreal Application of a Recombinant Adeno-associated Virus Vector Expressing CNGA1 (AAV2.NN-CNGA1) in Patients With Retinitis Pigmentosa Due to CNGA1 Mutations
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
Conditions: Retinitis Pigmentosa
Keywords: CNGA1 mutation
AAV2
Gene Therapy
Eye disease
Lead sponsor: ViGeneron GmbH
Sponsor class: INDUSTRY
First posted: 2024-03-04
Enrollment: 6
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: The goal of this phase 1 clinical trial is to learn about the safety and efficacy of a gene therapy, VG901, in patients with a rare disorder of the eye called Retinitis Pigmentosa. The main questions the study aims to answer are:

* What is the best tolerated dose and are there any side effects, in particular any inflammatory reactions post drug administration?
* Are there any early signs of efficacy on visual function?

Participants will be administered a single intravitreal dose of VG901 into the most affected eye through a syringe and followed up for a year to monitor safety and efficacy. There will be two cohorts of participants in this study. Study Cohort 1 will receive the low dose and Study Cohort 2 will receive the high dose as specified in the Protocol.


Eligibility criteria: Inclusion Criteria:

To be eligible for study entry, subjects must satisfy all the following criteria:

1. Able to understand and willing to consent to study participation by a written informed consent
2. Male or female ≥ 18 years of age
3. Clinical diagnosis of RP
4. Confirmed pathogenic, biallelic variants in the CNGA1 gene
5. Ellipsoid zone (EZ) length of the fovea of ≥ 3000 μm in the study eye

Exclusion Criteria:

Subjects will be excluded from the study if one or more of the following statements are applicable to either eye:

1. Additional interfering ocular conditions which would impact study results (e.g., ocular opacity and advanced cataract, uveitis, amblyopia)
2. History or presence of glaucoma
3. Ocular surgery, intravitreal or subretinal implantation of a medical device (within 6 months of screening)
4. Mutations known to cause inherited retinal disease other than biallelic variants in the CNGA1 gene
5. History of ocular infection with herpes simplex virus
6. History of ocular malignancies
7. History of disorders of the internal retina (e.g., retinal detachment)
8. Patients with uncontrolled diabetes (HbA1c \> 7%)
9. Any other retinopathy due to other diseases - including, but not limited to arterial hypertension, previous vascular retinal occlusion, trauma or acquired inflammatory diseases, contraindication to pharmacological mydriasis (e.g., history of angle block glaucoma), diabetes (diabetic retinopathy including macular oedema)
10. Absence of visual function on the contralateral eye
11. Any damage to the optic nerve
12. Individuals performing any other therapy for RP within 3 months before the study, such as - but not limited to - transcorneal electrostimulation
13. Systemic conditions (e.g., autoimmune disorders) which may affect study participation or outcome measures
14. History of immunodeficiency or other medical conditions which may increase the risk of VG901 administration
15. Systemic illness (e.g., hepatitis or human immunodeficiency virus \[HIV\] infection) or medically relevant abnormal laboratory values (3 x upper limit of normal \[ULN\]) in blood analysis including renal and hepatic function
16. Current, or recent, participation in other study/ or administration of investigational biologic agent within 3 months of Screening; Use of any investigational agent, or systemic corticosteroids, or other immunosuppressive drug(s) within 3 months before Screening
17. History of allergy or sensitivity to any compound used in the study
18. Contraindications to systemic immunosuppression
19. Subjects with increased risk of bleeding (i.e., use of anticoagulants or anti-platelet agents within 7 days before VG901 administration and subjects with international normalized ratio \> 2 or Quick \< 50% or partial thromboplastin time \> 50 seconds, thrombocytopenia, as well as any other known coagulopathy)
20. Subject/partner of childbearing potential unwilling to use adequate contraception for the period between Screening and 30 days after treatment, defined as the period from Screening until 30 days after treatment (defined as administration of therapeutic to the eye)
21. For females of childbearing potential, a positive pregnancy test at Screening or Baseline
22. Females who are breastfeeding
23. Previous receipt of any AAV gene therapy product
24. Any condition which leads the investigator to believe that subject cannot comply with the protocol requirements or that may place the subject at an unacceptable risk from participating

Primary outcomes:
measure: Adverse Events (AEs) and Serious Adverse Events (SAEs)
timeFrame: Baseline to Month 12
Secondary outcomes:
measure: Physical Examination
timeFrame: Screening to Month 12
measure: Pulse rate
timeFrame: Screening to Month 12
measure: Blood pressure
timeFrame: Screening to Month 12
measure: Body temperature
timeFrame: Screening to Month 12
measure: Respiratory rate
timeFrame: Screening to Month 12
measure: Slit lamp examination
timeFrame: Screening to Month 12
measure: Fundus biomicroscopy
timeFrame: Screening to Month 12
measure: Optical coherence tomography (OCT)
timeFrame: Screening to Month 12
measure: Fundus autofluorescence
timeFrame: Screening to Month 12
measure: Tonometry
timeFrame: Screening to Month 12
measure: Adeno-associated virus (AAV) spread
timeFrame: From Baseline until two consecutive samples test negative
measure: Immunopathology
timeFrame: Baseline to Month 12
Other outcomes:
Locations:
city: Tuebingen
country: Germany
facility: Center for Ophthalmology, University of Tuebingen
Study officials:
affiliation: Center for Ophthalmology, University of Tuebingen
name: Katarina Stingl
role: PRINCIPAL_INVESTIGATOR
References: