Clinical trial NCT00057720: TLK286 (Telcyta) vs. Doxil/Caelyx or Hycamtin in Platinum Refractory or Resistant Ovarian Cancer
Official title: Phase 3 Randomized Study of TLK286 (Telcyta) Versus Doxil/Caelyx or Hycamtin as Third-Line Therapy in Platinum Refractory or Resistant Ovarian Cancer [ASSIST-1 (Assessment of Survival In Solid Tumors-1)]
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Ovarian Neoplasms
Keywords: ovary
Lead sponsor: Telik
Sponsor class: INDUSTRY
First posted: 2003-04-08
Enrollment: 440
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to demonstrate superiority in survival in favor of TLK286 as compared to active control therapy with Doxil/Caelyx or Hycamtin in the intent-to-treat (ITT) populations.


Eligibility criteria: Inclusion criteria include:

* Considered platinum refractory or resistant according to standard criteria
* Progressed during or following completion of one second-line treatment with Doxil/Caelyx or Hycamtin
* Histologically or cytologically confirmed diagnosis of epithelial cancer of the ovary, fallopian tube, or primary peritoneal cancer
* Measurable disease according to RECIST criteria with documented tumor progression

Exclusion criteria include:

* Treatment with second-line chemotherapy other than Doxil/Caelyx or Hycamtin
* History of whole pelvis radiation therapy within 12 months of enrollment
* Clinically significant cardiac disease
* Evidence of gross hematuria at the time of study entry
* Any signs of intestinal obstruction interfering with nutrition at the time of study entry
* Pregnant or lactating women

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Little Rock
country: United States
facility: Little Rock Hematology Oncology Associates
state: Arkansas
city: Little Rock
country: United States
facility: University of Arkansas for Medical Sciences
state: Arkansas
city: Baldwin Park
country: United States
facility: Southern California Permanente Medical Group
state: California
city: Burbank
country: United States
facility: Providence Saint Joseph Medical Center
state: California
city: Chula Vista
country: United States
facility: Marilyn Norton, M. D.
state: California
city: Chula Vista
country: United States
facility: Rosalba Rodriguez, M. D.
state: California
city: Concord
country: United States
facility: Bay Area Research Cancer Group
state: California
city: Escondido
country: United States
facility: Southwest Cancer Care
state: California
city: Fresno
country: United States
facility: California Oncology of the Central Valley
state: California
city: Hayward
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: La Jolla
country: United States
facility: Gynecologic Oncology Associates
state: California
city: La Mesa
country: United States
facility: Grossmont Hospital
state: California
city: La Mesa
country: United States
facility: Sharp Rees-Stealy
state: California
city: Loma Linda
country: United States
facility: LLU Faculty Medical Offices
state: California
city: Loma Linda
country: United States
facility: LLU Faculty Meidical Offices
state: California
city: Loma Linda
country: United States
facility: Loma Linda University Medical Center
state: California
city: Los Angeles
country: United States
facility: David Geffen School of Medicine at UCLA
state: California
city: Los Gatos
country: United States
facility: Women's Cancer Center - Community Hospital Los Gatos
state: California
city: Murrieta
country: United States
facility: Southwest Cancer Care
state: California
city: Newport Beach
country: United States
facility: Gyncologic Oncology Associates
state: California
city: Oakland
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: Oceanside
country: United States
facility: N. County Oncology Medical
state: California
city: Poway
country: United States
facility: Southwest Cancer Care
state: California
city: Redwood City
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: Roseville
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: Sacramento
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: San Diego
country: United States
facility: Southern California Permanente Medical Group
state: California
city: San Diego
country: United States
facility: Medical Oncology Associates-SD
state: California
city: San Diego
country: United States
facility: Sharp Healthcare Clinical Oncology Research
state: California
city: San Diego
country: United States
facility: Sharp Memorial Hospital
state: California
city: San Diego
country: United States
facility: Sharp Rees-Stealy
state: California
city: San Francisco
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: San Rafael
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: Santa Clara
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: Santa Rosa
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: Santa Teresa
country: United States
facility: Kaiser Permanente Oncology Clinical Trails Program
state: California
city: South San Francisco
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: Vallejo
country: United States
facility: Kaiser Permanente Oncology Clinical Trials Program
state: California
city: Walnut Creek
country: United States
facility: Kaiser Permanente Oncology Clinial Trials Program
state: California
city: Norwalk
country: United States
facility: Whittingham Cancer Center at Norwalk Hospital
state: Connecticut
city: Stamford
country: United States
facility: Hematology Oncology, P.C.
state: Connecticut
city: Boca Raton
country: United States
facility: The Center for Hematology-Oncology
state: Florida
city: Delray Beach
country: United States
facility: The Center for Hematology-Oncology
state: Florida
city: Hollywood
country: United States
facility: Memorial Regional Hospital
state: Florida
city: Hollywood
country: United States
facility: Sheridan Clinical Research, Inc.
state: Florida
city: Jacksonville
country: United States
facility: University of Florida Health Science Center/Jacksonville
state: Florida
city: Orlando
country: United States
facility: Florida Hospital
state: Florida
city: Orlando
country: United States
facility: Gynecologic Oncology
state: Florida
city: Ormond Beach
country: United States
facility: Florida Hospital Memorial Division, Cancer Care Center
state: Florida
city: Ormond Beach
country: United States
facility: Florida Hospital Memorial Division
state: Florida
city: Palm Beach Gardens
country: United States
facility: Palm Beach Cancer Institute
state: Florida
city: Pembroke Pines
country: United States
facility: Gynecologic Oncology Associates
state: Florida
city: Port St. Lucie
country: United States
facility: Hematology/Oncology Associates of Treasure Coast
state: Florida
city: S. Miami
country: United States
facility: Women's Cancer Research Foundation, Inc.
state: Florida
city: Wellington
country: United States
facility: Palm Beach Cancer Institute
state: Florida
city: West Palm Beach
country: United States
facility: Palm Beach Cancer Institute
state: Florida
city: Duluth
country: United States
facility: Suburban Hematology Oncology
state: Georgia
city: Lawrenceville
country: United States
facility: Suburban Hematology-Oncology Associates
state: Georgia
city: Savannah
country: United States
facility: Memorial Health University Medical Center
state: Georgia
city: Snellville
country: United States
facility: Suburban Hematology Oncology
state: Georgia
city: Honolulu
country: United States
facility: Kaiser Permanente - Moanalua Medical Center
state: Hawaii
city: Honolulu
country: United States
facility: Straub Clinic and Hospital
state: Hawaii
city: Honolulu
country: United States
facility: Univ. of Hawaii, Kapiolani Medical Center for Women and Children
state: Hawaii
city: Barrington
country: United States
facility: North Shore Oncology Hematology Associates
state: Illinois
city: Berwyn
country: United States
facility: MacNeal Cancer Center
state: Illinois
city: Chicago
country: United States
facility: Swedish Covenant Cancer Center
state: Illinois
city: Chicago
country: United States
facility: Hematology Oncology Associates of Illinois (HOAI)
state: Illinois
city: Decatur
country: United States
facility: Cancer Care Specialists of Central IL
state: Illinois
city: Decatur
country: United States
facility: Decatur Memorial Hospital
state: Illinois
city: Effingham
country: United States
facility: Cancer Care Specialists of Central IL-Crossroads Cancer Care Center
state: Illinois
city: Flossmoor
country: United States
facility: Joliet Oncology-Hematology Associates, Ltd.
state: Illinois
city: Joliet
country: United States
facility: Joliet Oncology-Hematology Associates, Ltd.
state: Illinois
city: Lake Forest
country: United States
facility: North Shore Oncology Hematology Associates - Deerpath Medical Associates
state: Illinois
city: Libertyville
country: United States
facility: North Shore Oncology Hematology Associates
state: Illinois
city: McHenry
country: United States
facility: North Shore Oncology Hematology Associates
state: Illinois
city: Morris
country: United States
facility: Joliet Oncology-Hematology Associates, Ltd.
state: Illinois
city: Skokie
country: United States
facility: Hematology Oncology Associates of Illinois (HOAI)
state: Illinois
city: Skokie
country: United States
facility: Midwest Cancer Research Group, Inc.
state: Illinois
city: Elkhart
country: United States
facility: Elkhart General Hospital
state: Indiana
city: Elkhart
country: United States
facility: Michiana Hematology Oncology
state: Indiana
city: Indianapolis
country: United States
facility: Indiana Cancer Pavilion
state: Indiana
city: Indianapolis
country: United States
facility: Indiana University Medical Center
state: Indiana
city: Indianapolis
country: United States
facility: St. Vincent Gynecologic Oncology
state: Indiana
city: Indianapolis
country: United States
facility: St. Vincent Hospital and Health Care Center
state: Indiana
city: Indianapolis
country: United States
facility: St. Vincent Hospital and Helath Care Center
state: Indiana
city: South Bend
country: United States
facility: Michiana Hematology Oncology
state: Indiana
city: South Bend
country: United States
facility: St. Joseph's Regional
state: Indiana
city: South Bend
country: United States
facility: Saint Joseph's Regional
state: Indiana
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics
state: Iowa
city: Iowa City
country: United States
facility: University of Iowa
state: Iowa
city: Wichita
country: United States
facility: Research Support Personnel, LLC
state: Kansas
city: Wichita
country: United States
facility: Associates in Women's Health
state: Kansas
city: Crestview
country: United States
facility: Oncology/Hematology Care, Inc.
state: Kentucky
city: Louisville
country: United States
facility: Univ. of Louisville, Div. of Gynecologic Oncology
state: Kentucky
city: Covington
country: United States
facility: Hematology and Oncology Specialists, LLC
state: Louisiana
city: Metairie
country: United States
facility: OncRx (Pharmacy)
state: Louisiana
city: New Orleans
country: United States
facility: Hematology and Oncology Specialists, LLC
state: Louisiana
city: New Orleans
country: United States
facility: Ochsner Clinic Foundation
state: Louisiana
city: Shreveport
country: United States
facility: LSU Health Sciences Center
state: Louisiana
city: Baltimore
country: United States
facility: Sinai Cancer Institute
state: Maryland
city: Bethesda
country: United States
facility: Center for Cancer and Blood Disorders
state: Maryland
city: Boston
country: United States
facility: St. Elizabeth's Med. Ctr.
state: Massachusetts
city: Ann Arbor
country: United States
facility: St. Joseph Mercy Hospital
state: Michigan
city: Lansing
country: United States
facility: Sparrow Regional Cancer Center
state: Michigan
city: Duluth
country: United States
facility: St. Mary's Duluth Clinic
state: Minnesota
city: Columbia
country: United States
facility: Ellis Fischel Cancer Center
state: Missouri
city: St. Louis
country: United States
facility: St. Louis University, Dept. of Ob-Gyn and Women's Health
state: Missouri
city: St. Louis
country: United States
facility: Gynecology & Oncology Consultants, PC
state: Missouri
city: St. Louis
country: United States
facility: Saint John's Mercy Hospital
state: Missouri
city: Billings
country: United States
facility: Deaconess Billings Clinic
state: Montana
city: Billings
country: United States
facility: Hematology & Oncology Centers Northern Rockies
state: Montana
city: Butte
country: United States
facility: Hematology Oncology Centers of the Northern Rockies
state: Montana
city: Scottsbluff
country: United States
facility: Horizon's West Medical Group
state: Nebraska
city: Las Vegas
country: United States
facility: Nevada Cancer Center
state: Nevada
city: Neptune
country: United States
facility: Jersey Shore University Medical Center
state: New Jersey
city: New Brunswick
country: United States
facility: The Cancer Institute of New Jersey
state: New Jersey
city: New Brunswick
country: United States
facility: Robert Wood Johnson University Hospital
state: New Jersey
city: Albuquerque
country: United States
facility: UNM Cancer Research and Treatment Center
state: New Mexico
city: Babylon
country: United States
facility: Benjamin Schwartz, M.D.
state: New York
city: Cooperstown
country: United States
facility: The Mary Imogene Bassett Hospital
state: New York
city: Malone
country: United States
facility: Med-Onc/Hem
state: New York
city: New City
country: United States
facility: Hematology-Oncology Associates of Rockland
state: New York
city: New Hyde Park
country: United States
facility: Long Island Jewish Medical Center
state: New York
city: New Hyde Park
country: United States
facility: North Shore-Long Island Jewish Health System/Medical Center
state: New York
city: New York
country: United States
facility: Bellevue Hospital Center
state: New York
city: New York
country: United States
facility: Comprehensive Cancer Center Medical Practice Offices
state: New York
city: New York
country: United States
facility: New York University Medical Center - Tisch Hospital
state: New York
city: New York
country: United States
facility: NYU School of Medicine
state: New York
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
city: Nyack
country: United States
facility: The Union State Bank Cancer Center at Nyack Hospital
state: New York
city: Rochester
country: United States
facility: Gynecologic-Oncology
state: New York
city: West Islip
country: United States
facility: Good Samaritan Hospital Medical Center
state: New York
city: West Islip
country: United States
facility: South Bay OB/GYN
state: New York
city: Charlotte
country: United States
facility: Blumenthal Cancer Center
state: North Carolina
city: Charlotte
country: United States
facility: Presbyterian Gynecologic Oncology
state: North Carolina
city: Charlotte
country: United States
facility: Presbyterian Hospital Center for Cancer Research
state: North Carolina
city: Winston-Salem
country: United States
facility: Piedmont Hematology Oncology Assoc., PA-Salem Research Group
state: North Carolina
city: Winston-Salem
country: United States
facility: Salem Research Group, Inc.
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest University School of Medicine
state: North Carolina
city: Bismarck
country: United States
facility: Mid Dakota Clinic
state: North Dakota
city: Bismarck
country: United States
facility: Odyssey Research Services
state: North Dakota
city: Fargo
country: United States
facility: Dakota Cancer Institute
state: North Dakota
city: Fargo
country: United States
facility: Odyssey Research Services
state: North Dakota
city: Cincinnati
country: United States
facility: Oncology/Hematology Care, Inc.
state: Ohio
city: Cincinnati
country: United States
facility: Barrett Cancer Center
state: Ohio
city: Cincinnati
country: United States
facility: Barrett Cancer Center
state: Ohio
city: Cincinnati
country: United States
facility: Oncology/Hematology Care, Inc.
state: Ohio
city: Cincinnati
country: United States
facility: UC Physician's Medical Arts Bldg.
state: Ohio
city: Cincinnati
country: United States
facility: UC Physician's Medical Arts Building
state: Ohio
city: Cincinnati
country: United States
facility: University Hospital
state: Ohio
city: Cincinnati
country: United States
facility: Oncology/Hematology Care, Inc.
state: Ohio
city: Cincinnati
country: United States
facility: Oncology/Hematology Care, Inc.
state: Ohio
city: Cincinnati
country: United States
facility: Oncology/Hematology Care, Inc.
state: Ohio
city: Cleveland
country: United States
facility: Metro Health Medical Center
state: Ohio
city: Cleveland
country: United States
facility: MetroHealth Medical Center
state: Ohio
city: Columbus
country: United States
facility: Mid-Ohio Oncology Hematology St. Anne's
state: Ohio
city: Columbus
country: United States
facility: Mid Ohio Oncology Hematology
state: Ohio
city: Columbus
country: United States
facility: Mid-Ohio Oncology Hematology
state: Ohio
city: Columbus
country: United States
facility: Gynecologic Oncology
state: Ohio
city: Columbus
country: United States
facility: Mount Carmel Health
state: Ohio
city: Dayton
country: United States
facility: Wright State Univ. School of Medicine
state: Ohio
city: Mayfield Heights
country: United States
facility: Hillcrest Hospital Cancer Center
state: Ohio
city: Oklahoma City
country: United States
facility: OU Medical Center - Everett Tower
state: Oklahoma
city: Oklahoma City
country: United States
facility: OU Physicians' Bldg.
state: Oklahoma
city: Oklahoma City
country: United States
facility: Presbyterian
state: Oklahoma
city: Oklahoma City
country: United States
facility: University of Oklahoma Health Sciences Center
state: Oklahoma
city: Portland
country: United States
facility: Kaiser Permanente Nw, Oncology Research
state: Oregon
city: Portland
country: United States
facility: Oregon Health & Science University
state: Oregon
city: Portland
country: United States
facility: Oregon Health Science University
state: Oregon
city: Abington
country: United States
facility: Abington Mem. Hospita/Rosenfield Cancer Center
state: Pennsylvania
city: Dunmore
country: United States
facility: Advanced Imaging
state: Pennsylvania
city: Dunmore
country: United States
facility: Hematology & Oncology Associates of NEPA
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Magee-Womens Hospital
state: Pennsylvania
city: Scranton
country: United States
facility: Viewmont Medical Services
state: Pennsylvania
city: Scranton
country: United States
facility: Community Medical Center
state: Pennsylvania
city: Scranton
country: United States
facility: Mercy Health Partners
state: Pennsylvania
city: Scranton
country: United States
facility: Moses Taylor Hospital
state: Pennsylvania
city: Upland
country: United States
facility: Associates in Hematology-Oncology, P.C.
state: Pennsylvania
city: Charleston
country: United States
facility: Carolina Center of Gynecologic Oncology, PA
state: South Carolina
city: Columbia
country: United States
facility: South Carolina Oncology Associates, PA
state: South Carolina
city: Greenville
country: United States
facility: Gynecologic Oncology Research and Development
state: South Carolina
city: Spartanburg
country: United States
facility: Gynecologic Oncology Research and Development
state: South Carolina
city: Sioux Falls
country: United States
facility: Sioux Valley Clinic Clinical Research Center
state: South Dakota
city: Sioux Falls
country: United States
facility: Sioux Valley Clinic Oncology
state: South Dakota
city: Sioux Falls
country: United States
facility: Sioux Valley Hospital - North Center Radiology
state: South Dakota
city: Sioux Falls
country: United States
facility: Sioux Calley Clinic OBGYN Ltd.
state: South Dakota
city: Chattanooga
country: United States
facility: Chattanooga Oncology & Hematology Associates, P.C.
state: Tennessee
city: Chattanooga
country: United States
facility: Memorial Hospital
state: Tennessee
city: Franklin
country: United States
facility: The Consultant Group
state: Tennessee
city: Gallatin
country: United States
facility: The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
state: Tennessee
city: Hermitage
country: United States
facility: The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
state: Tennessee
city: Knoxville
country: United States
facility: Saint Mary's Health System, Inc.
state: Tennessee
city: Knoxville
country: United States
facility: Hall and Martin, M.D.'s, P.C.
state: Tennessee
city: Knoxville
country: United States
facility: Fort Sanders Parkwest Medical Center
state: Tennessee
city: Lebanon
country: United States
facility: The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
state: Tennessee
city: Murfreesboro
country: United States
facility: The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
state: Tennessee
city: Nashville
country: United States
facility: The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
state: Tennessee
city: Nashville
country: United States
facility: The Consultant Group
state: Tennessee
city: Nashville
country: United States
facility: The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
state: Tennessee
city: Nashville
country: United States
facility: The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
state: Tennessee
city: Nashville
country: United States
facility: The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
state: Tennessee
city: Smyma
country: United States
facility: The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
state: Tennessee
city: Amarillo
country: United States
facility: Amarillo Cancer Center
state: Texas
city: Arlington
country: United States
facility: Arlington Cancer Center
state: Texas
city: Dallas
country: United States
facility: Dallas Oncology Consultants
state: Texas
city: Dallas
country: United States
facility: Texas Cancer Associates
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology, PA
state: Texas
city: Fort Worth
country: United States
facility: Southwest Fort Worth Cancer Center
state: Texas
city: Houston
country: United States
facility: Univ. of TX, MD Anderson Cancer Center
state: Texas
city: Danville
country: United States
facility: Danville Hematology and Oncology, Inc.
state: Virginia
city: Aberdeen
country: United States
facility: Western Washington Oncology
state: Washington
city: Centralia
country: United States
facility: Western Washington Oncology
state: Washington
city: Covington
country: United States
facility: Covington Multicare - Oncology Clinic
state: Washington
city: Olympia
country: United States
facility: Western Washington Oncology
state: Washington
city: Olympia
country: United States
facility: Western Washington Oncology
state: Washington
city: Shelton
country: United States
facility: Western Washington Oncology
state: Washington
city: Tacoma
country: United States
facility: Allenmore Hospital - Hematology Oncology Clinic
state: Washington
city: Tacoma
country: United States
facility: MultiCare Health System - Medical Oncology
state: Washington
city: Chippewa Falls
country: United States
facility: Chippewa Falls Cancer Center
state: Wisconsin
city: Eau Claire
country: United States
facility: Regional Cancer Center
state: Wisconsin
city: Marshfield
country: United States
facility: Marshfield Clinic Research Foundation
state: Wisconsin
city: Marshfield
country: United States
facility: Saint Joseph's Hospital
state: Wisconsin
city: Marshfield
country: United States
facility: Wisconsin Rapid Cancer Center
state: Wisconsin
city: Merrill
country: United States
facility: Merrill Cancer Center
state: Wisconsin
city: Milwaukee
country: United States
facility: Medical Consultants, Ltd.
state: Wisconsin
city: Minocqua
country: United States
facility: Marshfield Clinc - Lakeland Center
state: Wisconsin
city: Minocqua
country: United States
facility: Marshfield Clinic - Lakeland Center
state: Wisconsin
city: Rice Lake
country: United States
facility: Diagnostic Radiology Associates
state: Wisconsin
city: Rice Lake
country: United States
facility: Lakeview Medical Center
state: Wisconsin
city: Rice Lake
country: United States
facility: Marshfield Clinic - Indianhead Center
state: Wisconsin
city: Stevens Point
country: United States
facility: Saint Michael Hospital
state: Wisconsin
city: Wausau
country: United States
facility: Wausau Cancer Center
state: Wisconsin
city: Cody
country: United States
facility: Hematology Oncology Centers of the Northern Rockies
state: Wyoming
city: Sheridan
country: United States
facility: Hematology Oncology of the Northern Rockies
state: Wyoming
city: Bahia Blanca
country: Argentina
facility: Hospital Italiano Regional del Sur
state: Buenos Aires
city: Capital Federal
country: Argentina
facility: Hospital General de Agudos Donacion F. Santojanni
state: Buenos Aires
city: Pilar
country: Argentina
facility: Hospital Universitario Austral
state: Buenos Aires
city: Buenos Aires
country: Argentina
facility: Hospital Donacion Francisco Santojanni
city: Buenos Aires
country: Argentina
facility: Complejo Medico de la Policia Federal Argentina "Churruca-Visca"
city: Buenos Aires
country: Argentina
facility: Hospital Italiano de Buenos Aires
city: Buenos Aires
country: Argentina
facility: Sanatorio Municipal Dr. Julio Mendez
city: Buenos Aires
country: Argentina
facility: Hospital General de Agudos "Carlos G. Durand"
city: Buenos Aires
country: Argentina
facility: Complejo Medico de la Policia Federal Argentina "Churruca-Visca"
city: Buenos Aires
country: Argentina
facility: Hospital de Oncologia Maria Curie
city: Buenos Aires
country: Argentina
facility: Policlinica Privada Instituto de Medicina Nuclear
city: Cordoba
country: Argentina
facility: Sociedad de Beneficencia Hospital Italiano
city: Santa Fe
country: Argentina
facility: ISIS Clinica Especializada
city: Lindedreef
country: Belgium
facility: Algemeen Ziekenhuis Antwerpen
state: Antwerpen
city: Wilrijkstraat
country: Belgium
facility: Universitaire Ziekenhuis Antwerpen
state: Edegem
city: Herestraat
country: Belgium
facility: University Hospital Gasthuisberg
state: Leuven
city: Brussels
country: Belgium
facility: AZ-VUB Dienst Oncologie
city: Brussels
country: Belgium
facility: Cliniques Universitaires Saint-Luc
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent.
city: Liege
country: Belgium
facility: Centre Hospitalier Regional de la Citadelle
city: Fortaleza
country: Brazil
facility: Instituto do Cancer do Ceara
state: CE
city: Belo Horizonte
country: Brazil
facility: Hospital Vera Cruz
state: MG
city: Belo Horizonte
country: Brazil
facility: Hospital Luxemburgo
state: MG
city: Bairro Bom Fim
country: Brazil
facility: Hospital de Clinicas de Porto Alegre
state: Porto Alegre
city: Curitiba
country: Brazil
facility: Hospital de Clinicas da Universidade Federal do Parana
state: PR
city: Londrina
country: Brazil
facility: Centro de Tratamento Oncologico de Londrina
state: PR
city: Sao Paolo
country: Brazil
facility: Instituto Arnaldo Vieira de Carvalho
state: SP
city: Sao Paolo
country: Brazil
facility: Hospital das Clinicas de Sao Paulo-FMUSP
state: SP
city: Rio de Janeiro
country: Brazil
facility: INCA Hospital de Oncologia Clinica
city: Sao Paolo
country: Brazil
facility: Hospital do Cancer - A.C. Camargo
city: Sao Paolo
country: Brazil
facility: Instituto de Saude e Bem Estar da Mulher
city: Sao Paulo
country: Brazil
facility: Unifesp/Epm
city: Independencia
country: Chile
facility: Servicio de Oncologia-Hospital Clinico Unversidad de Chile
state: Santiago
city: Santiago de Chile
country: Chile
facility: Clinica Santa Maria
city: Pardubice
country: Czech Republic
facility: Fakultni nemocnice Olomouc, Onkologicka klinika
state: Olomouc
city: Kyjevska 44
country: Czech Republic
facility: Krajska nemocnice Pardubice, Oddeleni radiacni onklogie
state: Pardubice
city: Doudlevecka 69
country: Czech Republic
facility: Fakultni Nemocnice - Onkologicka Klinika
state: Plzen
city: Unemocnice
country: Czech Republic
facility: Vseobecna Fakultni Nemocnice - Onkologicka Klinika
state: Praha
city: Havlickovo nabrezi 600
country: Czech Republic
facility: Batova krajska nemocnice Zlin, prispevkova organizace, Onkologicke oddeleni
state: Zlin
city: Havlickovo nabrezi
country: Czech Republic
facility: Batova krajska nemocnice Zlin, prispevkova organizace, Radiodiagnosticke oddeleni
state: Zlin
city: Brno
country: Czech Republic
facility: Masarykuv Onkologicky Ustav
city: Plzen
country: Czech Republic
facility: Fakultni nemocnice, Onkologicka klinika
city: Berlin
country: Germany
facility: Universitatsklinikum Charite - Campus Virchow-Klinikum
city: Karlsruhe
country: Germany
facility: St. Vincentius Kliniken
city: Karlsruhe
country: Germany
facility: St. Vincentius Kliniken - Frauenkinik
city: Karlsruhe
country: Germany
facility: St. Vincentius Kliniken - Radiology
city: Munich
country: Germany
facility: Klinikum GroBhadern-Institut fur Radiologie
city: Munich
country: Germany
facility: Klinikum GroBhadern-Zentrum fur Frauenheilkunde
city: Ulm
country: Germany
facility: Universitaets-Frauenklinik Ulm
city: Wiesbaden
country: Germany
facility: Dr. Horst-Schmidt-Kliniken GmbH
city: Baross
country: Hungary
facility: Semmelweis University, 1st Dept. of Obstetrics and Gynaecology
city: Budapest
country: Hungary
facility: Uzsoki Street Hospital Dept. of Radiooncology
city: Debrecen
country: Hungary
facility: Faculty of Gynaecologycal Oncology/Univ. of Debrecen
city: Pecs
country: Hungary
facility: Baranya County Hospital
city: Rakoczi
country: Hungary
facility: Baranya County Hospital - Department of Oncology
city: Rakoczi
country: Hungary
facility: Baranya County Hospital - Department of Radiology
city: Szeged
country: Hungary
facility: SZTE, Department of Oncotherapy
city: Belfast
country: Ireland
facility: Oncology Dept., University Floor, Belfast City Hospital
city: HV Amsterdam
country: Netherlands
facility: Vrije Universiteit Medical Centre (VUMC)
city: Nijmegen
country: Netherlands
facility: University Medical Centre Nijmegen (UMCN)
city: Panorama
country: South Africa
facility: Panorama Medical Centre
state: Cape Town
city: Overport
country: South Africa
facility: Hopelands Cancer Centre
state: Durban
city: Rosebank
country: South Africa
facility: Medical and Dental Centre
state: Johannesburg
city: Saxonwold
country: South Africa
facility: Rosebank Oncology Centre
state: Johannesburg
city: Die Wilgers x14
country: South Africa
facility: Wilgers Oncology Centre
state: Pretoria
city: Port Elizabeth
country: South Africa
facility: Eastern Cape Oncology Research Centre
city: Vall d'Hebron
country: Spain
facility: Servicio Oncologia Hospital General Vall d'HebronPaseo
state: Barcelona
city: Profesor Beltran Baguena
country: Spain
facility: Instituto Valenciano de Oncologia (IVO)
state: Valencia
city: Barcelona
country: Spain
facility: Hospital Clinic i Provincial de Barcelona - Servicio de Oncologia Medica
city: Barcelona
country: Spain
facility: Hospital Clinic i Provincial
city: Guadalajara
country: Spain
facility: Hospital General de Guadalajara
city: Madrid
country: Spain
facility: Servicio de Oncologia
city: Valencia
country: Spain
facility: Instituto Valenciano de Oncologia (IVO) Servicio de Oncologia
city: Valencia
country: Spain
facility: Instituto Valenciano de Oncologia (IVO) Servicio de Radiologia
city: Scotland
country: United Kingdom
facility: Department of Cancer Medicine - Ninewells Hospital & Medical School
state: Dundee
city: Sutton
country: United Kingdom
facility: Dept. of Med. Oncology/The Royal Marsden Hospital
state: Surrey
city: Birmingham
country: United Kingdom
facility: St. Chad's Outpatients Unit, City Hospital
city: Bristol
country: United Kingdom
facility: United Bristol Healthcare Trust - Bristol Oncology Centre
city: Glasgow
country: United Kingdom
facility: Beatson Oncology Centre
city: Glasgow
country: United Kingdom
facility: Beatson Oncology Unit
city: London
country: United Kingdom
facility: Medical Oncology - Guy's and St. Thomas' Hospital
city: London
country: United Kingdom
facility: Department of Medicine-Royal Marsden Hospital
city: Manchester
country: United Kingdom
facility: Department of Medical Oncology, Christie Hospital
city: Newcastle-upon-Tyne
country: United Kingdom
facility: Medical Oncology (NCCT) - Newcastle General Hospital
city: Poole
country: United Kingdom
facility: Dorset Cancer Centre - Poole Hospital
city: Wales
country: United Kingdom
facility: Velindre NHS Trust - Velindre Hospital
Study officials:
References: