Clinical trial NCT06678386: Alteration of Sweet Taste Perception After Reduction of Sweet Food and Beverage Consumption.
Official title: Alteration of Sweet Taste Perception After 50% Reduction of Sweet Food and Beverage Consumption for 12 Weeks, Compared With Unmodified Diet.
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Health-Related Behavior
Keywords: sweet taste perception
sugar reduction
dietary behavior
dietary modification
sweet intensity
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2024-11-07
Enrollment: 58
Sex: ALL
Minimum age (years): 18
Maximum age (years): 59
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The goal of this clinical trial is to determine whether reducing sugar intake by 50% for 12 weeks can change sweet taste perception in healthy adults and its consequences. The main questions it aims to answer are:

* Does sweet intensity change after reducing daily sugar intake by 50% for 12 weeks?
* How does sweet intensity change after completing dietary modification for 8 weeks?
* Does individual daily sugar intake change after completing dietary modification for 8 weeks?

Researchers will compare reducing daily sugar intake by 50% for 12 weeks to an unmodified diet to see if sugar reduction can change sweet intensity.

Participants will:

* Reduce daily sugar intake by 50% or maintain an unmodified diet for 12 weeks.
* Visit the clinic three times for anthropometric measurements, sweet perception tests, and to complete questionnaires.
* Keep a diet record for a total of 15 days during the research period.


Eligibility criteria: Inclusion Criteria:

* People with a fasting blood sugar level below 126 mg/dL or an HbA1C below 6.5% in the past 6 months, who are not currently being treated for diabetes.
* People who score 10 or more points on the sweet food consumption behavior questionnaire.
* People who are able to communicate in the Thai language.
* People who are able to chat and use video calls via the Line application.
* People who agree to modify their diet and beverages according to the recommendations of a dietitian.
* People who agree to undergo sweet taste testing, complete a food record, and fill out a questionnaire.

Exclusion Criteria:

* People with uncontrolled chronic conditions who have had changes in their treatment within the past 3 months.
* People with a history of severe illness in the past 6 months.
* People who regularly use medication, excluding contraceptives and vitamins.
* Pregnant women.
* People who have experienced a weight change of at least 10% over the past 3 months.

Primary outcomes:
measure: Sweet intensity change from baseline after 12 weeks of the intervention.
timeFrame: 16 weeks from baseline (12 weeks after the start of the intervention)
Secondary outcomes:
measure: Sweet intensity change from baseline after completing the intervention for 8 weeks.
timeFrame: 24 weeks from baseline
measure: Changes in sugar consumption behavior from baseline
timeFrame: 24 weeks from baseline
Other outcomes:
Locations:
city: Bangkoknoi
country: Thailand
facility: Faculty of Medicine Siriraj Hospital, Mahidol University
state: Bangkok
Study officials:
References: