Clinical trial NCT02049645: The Suitability of Sniff Dog as a Tool in Screening Tumors
Official title: The Suitability of Sniff Dog as a Tool in Screening Tumors-- a Prospective Observational Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Neoplasia
Keywords: lung cancer
breast cancer
Lead sponsor: Central South University
Sponsor class: OTHER
First posted: 2014-01-30
Enrollment: 4000
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The Third Xiang-Ya Hospital staff members and their adult family members who wish to participate the study.

Brief summary: Previous studies have demonstrated that sniff dogs can identify cancer patients from healthy subjects through sniffing exhaled breath air or blood or serum or urine or feces. It is hypothesized that sniff dogs may be used as a tool in screening cancer patients in health examination. Trained dogs will sniff serum from participants who are attending the annual health examination to identify potential or high risk subjects, and the results will be compared with the outcome of the traditional health examination, and the high risk subjects will be followed periodically for at least five years.


Eligibility criteria: Inclusion Criteria:

* old than 20 years
* currently without cancer diagnosed with pathological examination
* allow the study team to examine his/her case history and incoming record

Exclusion Criteria:

* cancer patients with pathological diagnosis
* who does not allow the study team to examine his/her case history and incoming record

Primary outcomes:
measure: Sensitivity and specificity in screening cancer patients
timeFrame: up to 5 years
Secondary outcomes:
measure: Behavior patterns of sniff dogs to different diseases
timeFrame: up to 5 years
Other outcomes:
measure: The substances used by the sniff dogs to identifying tumors
timeFrame: up to 5 years
Locations:
city: Changsha
country: China
facility: The Third Xiang-Ya Hospital
state: Hunan
Study officials:
affiliation: Central South University
name: Chang-Qing Gao, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ehmann R, Boedeker E, Friedrich U, Sagert J, Dippon J, Friedel G, Walles T. Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon. Eur Respir J. 2012 Mar;39(3):669-76. doi: 10.1183/09031936.00051711. Epub 2011 Aug 18.
citation: Church J, Williams H. Another sniffer dog for the clinic? Lancet. 2001 Sep 15;358(9285):930. doi: 10.1016/S0140-6736(01)06065-2. No abstract available.
citation: Willis CM, Church SM, Guest CM, Cook WA, McCarthy N, Bransbury AJ, Church MR, Church JC. Olfactory detection of human bladder cancer by dogs: proof of principle study. BMJ. 2004 Sep 25;329(7468):712. doi: 10.1136/bmj.329.7468.712.
citation: McCulloch M, Jezierski T, Broffman M, Hubbard A, Turner K, Janecki T. Diagnostic accuracy of canine scent detection in early- and late-stage lung and breast cancers. Integr Cancer Ther. 2006 Mar;5(1):30-9. doi: 10.1177/1534735405285096.
citation: Horvath G, Jarverud GA, Jarverud S, Horvath I. Human ovarian carcinomas detected by specific odor. Integr Cancer Ther. 2008 Jun;7(2):76-80. doi: 10.1177/1534735408319058. Epub 2008 May 27.