louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05771792: Comparison of Eccentric Training on Injury Prevention and Hamstring Strength in Football Players
Official title: Comparison of Eccentric Training on Injury Prevention and Hamstring Strength in Football Players
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sport Injury
Exercise Therapy
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-03-16
Enrollment: 36
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To determine the effect of the eccentric exercise training on injury prevention and hamstring strength in football players.

Detailed description: Hamstrings injuries are common among footballers with a higher prevalence rate in male footballers. Despite the relatively high incidence of hamstring injuries in sports, no clear prevention methods have been identified. Most hamstring muscle injuries occur during an eccentric phase of any activity. Eccentric hamstring training has been used for injury prevention in recent years. The two distinguishing characteristics of eccentric muscle contractions have been well understood: 1) great force output; and 2) low energy cost to produce the force. Due to these distinguishing characteristics, eccentric exercise is widely used in injury prevention programs.

The aim of this study is to determine the effectiveness of eccentric training as compared to conventional training in hamstring muscle injury prevention and strengthing in football players.

Eligibility criteria: Inclusion Criteria:

* Football players with age 18 to 40
* Male
* Players playing football for \> 1 year

Exclusion Criteria:

* Having history of injury and surgery in past
* Those players having any kind of musculoskeletal, neurological, cardiovascular, or degenerative problems
* Those players who have any medical conditions

Primary outcomes:
measure: Hamstring Strength
timeFrame: 8 weeks
measure: Anaerobic Capacity
timeFrame: 8 weeks
measure: Agility
timeFrame: 8 weeks
Secondary outcomes:
measure: Injury Prevention ( FASH )
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Quetta
country: Pakistan
facility: Etihad Football Club
state: Balochistan
Study officials:
affiliation: Riphah International University
name: Saad Rauf, Ph.D*
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02812589: Diffusion Tensor Breast MRI (DTI)
Official title: Improving the Specificity of Breast MRI Through Diffusion Tensor Breast MRI (DTI)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Breast Cancer
Keywords: MRI
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
First posted: 2016-06-24
Enrollment: 267
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The breast MRI is used in the preoperative scenario to evaluate the extension of a newly diagnosed breast cancer and to screen the contralateral breast. The scan consists of a series of images taken after the use of intravascular contrast media that may detect areas of enhancement that look malignant, but are actually benign tissue, producing a false positive result. The investigators aim to evaluate a novel MRI sequence of images that does not use contrast, diffusion tensor imaging (DTI). Addition of DTI sequence does not add significantly to the time of standard breast MRI exam. This novel technique provides improved detection of tissue microstructure and is able to differentiate malignant from benign tumor. Hence, the investigators hypothesize that DTI may decrease the false positive rate when compared with standard dynamic contrast-enhanced (DCE) MRI.


Eligibility criteria: Inclusion Criteria:

* Female of any race, ethnicity and lifetime risk.
* Eighteen years or older.
* Known recent diagnosis of a breast cancer and normal clinical breast exam of the contralateral side.
* Self-detected lump suspicious for breast cancer that it has not been biopsied yet.

Exclusion Criteria:

* Inability to understand the consent form
* Pregnant or nursing
* Currently taking tamoxifen, evista (raloxifene), or an aromatase inhibitor for adjuvant therapy or chemoprevention
* Physically unable to lie down on her belly for at least 10 minutes.
* Have had benign needle biopsy of the breast performed within 3 months, or breast surgery within 1 year prior to MRI exam.

Primary outcomes:
measure: Validate DTI as a valuable adjunct to improve lesion characterization on breast MRI by using the difference in recall rates
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Princess Margaret Cancer Centre, University Health Network, 610 University Ave.
state: Ontario
Study officials:
affiliation: University Health Network, Toronto
name: Anabel Scaranelo, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06009289: Light and Sleep Fragmentation
Official title: Application of Precision Medicine to Phototherapy: a Stepped Care Approach to Consolidate Sleep and Slow Cognitive Decline in Older Adults
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE4
Conditions: Sleep
Mild Cognitive Impairment
Mood Disorders
Lead sponsor: VA Palo Alto Health Care System
Sponsor class: FED
Collaborators: name: National Institute on Aging (NIA)
First posted: 2023-08-24
Enrollment: 120
Sex: ALL
Minimum age (years): 65
Maximum age (years): 99
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: This trial will examine scheduled exposure to bright light in the morning and afternoon as a countermeasure to sleep fragmentation in older individuals with mild cognitive impairment.


Eligibility criteria: Inclusion Criteria:

* Mild Cognitive Impairment
* Age \>65

Exclusion Criteria:

* Severe depression
* Unstable psychiatric or medical disease
* Acute infection

Primary outcomes:
measure: Sleep fragmentation
timeFrame: 4 weeks
Secondary outcomes:
measure: Cognition
timeFrame: 6 months
measure: Mood
timeFrame: 6 months
Other outcomes:
Locations:
city: Redwood City
country: United States
facility: Stanford University
state: California
Study officials:
References:
Clinical trial NCT03006289: Relationship of Metabolic Syndrome and Its Components With Thyroid Cancer
Official title: Relationship of Metabolic Syndrome and Its Components With Thyroid Cancer
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Thyroid Cancer
Keywords: Metabolic Syndrome
fasting plasma glucose
Lead sponsor: Qianfoshan Hospital
Sponsor class: OTHER
First posted: 2016-12-30
Enrollment: 3000
Sex: ALL
Minimum age (years): 8
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients undergone thyroid surgery

Brief summary: The purpose of this study is to investigate the association between metabolic syndrome (MS), body mass index (BMI), hyperglycemia, dyslipidemia, hypertension and thyroid cancer. Screen for the risk factors that affect the incidence of thyroid cancer.


Eligibility criteria: Inclusion Criteria:

1. patients undergone thyroid surgery
2. signed the informed consent

Exclusion Criteria:

1.patients with no surgery

Primary outcomes:
measure: lipids
timeFrame: before the thyroid surgery
Secondary outcomes:
measure: glucose
timeFrame: before the thyroid surgery
Other outcomes:
measure: blood pressure
timeFrame: before the thyroid surgery
measure: Uric Acid
timeFrame: before the thyroid surgery
measure: sialic acid
timeFrame: before the thyroid surgery
measure: thyroid function
timeFrame: before the thyroid surgery
Locations:
Study officials:
affiliation: Qianfoshan Hospital
name: Lin Liao, MD
role: STUDY_CHAIR
References:
citation: Zhao J, Tian Y, Jia Z, Yao J, Liao L, Dong J. Abnormal Glucose Metabolism Parameters and the Aggressiveness of Differentiated Thyroid Carcinoma: A Hospital-Based Cross-Section Study in China. Front Endocrinol (Lausanne). 2022 Mar 1;13:806349. doi: 10.3389/fendo.2022.806349. eCollection 2022.
citation: Zhao J, Tian Y, Yao J, Gu H, Zhang R, Wang H, Liao L, Dong J. Hypercholesterolemia Is an Associated Factor for Risk of Differentiated Thyroid Cancer in Chinese Population. Front Oncol. 2021 Jan 28;10:508126. doi: 10.3389/fonc.2020.508126. eCollection 2020.
Clinical trial NCT03691389: Investigating the Relationship Between Parents and Their Children With ADHD and Conduct Disorder
Official title: Investigating the Relationship Between Children With ADHD and Conduct Disorder and Their Parents in Reduction of Symptoms
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Observation
Lead sponsor: Yale-NUS College
Sponsor class: OTHER
First posted: 2018-10-01
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: FAMILY_BASED
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study population consists parents of children who participated in a previous longitudinal study that investigates the effectiveness of omega-3 supplementation and social skills training in treating Conduct Disorder and Attention Deficit Hyperactivity Disorder (ADHD). The study ended noting that some children no longer meet the criteria of the disorders and based on existing literature, parental interactions may have a role in this phenomenon. As such, this research proposes to interview parents of these children to understand more.

Brief summary: This study aims to uncover mechanisms of action underlying any long-term change in youth antisocial behavior by considering the role of child and family characteristics as mediators and moderators of change. The study design is qualitative interviews to be conducted face-to-face with parents of children previously diagnosed with Conduct Disorder and Attention Deficit Hyperactivity Disorder (ADHD) but no longer meet diagnostic criteria. Questions will be asked to understand participants' parenting experience over time (before, during and after their children's treatment).


Eligibility criteria: Inclusion Criteria:

* Parents of children who participated in previous study "Supplements and Social Skills Intervention" conducted by Singapore Institute of Mental Health Child Guidance Clinic.
* Children no longer meet the criteria for Conduct Disorder and ADHD, as measured by Antisocial Process Screening Device (APSD) Callous-Unemotional score of 7 or less, and who do not meet the cut-off for rule-breaking and aggressive behavior determined by Child Behavior Checklist (CBCL). These data were collected from a previous study.

Exclusion Criteria:

* Children who still meet the requirements of Conduct Disorder and ADHD as defined above.
* Parents who did not indicate that they wish to be contacted for follow-up studies.

Primary outcomes:
measure: Parental style and interactions with children
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05588089: The Effect of Baby Care Training Given to Fathers After Birth
Official title: The Effect of Baby Care Training Given to Fathers After Birth on Paternal Attachment, Maternal Postpartum Depression and Quality of Life
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mothers
Fathers
Lead sponsor: Hitit University
Sponsor class: OTHER
First posted: 2022-10-20
Enrollment: 64
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Intervention model description: The study is of a semi-separate type and all women can be trained.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The aim of this study is to provide infant care training to fathers and to measure father-infant attachment and maternal postpartum depression and quality of life.

Detailed description: Objective: The aim of this study is to provide infant care training to fathers and to measure father-infant attachment and maternal postpartum depression and quality of life.

Design: The data for the study were collected using the introductory information form (IIF) and the father-infant attachment scale (FIAS) for fathers, Edinburgh Postpartum Depression Scale and Postpartum Quality of Life Scale for mothers.

Participants and setting: A total of 64 fathers and 64 mothers, including 32 in the intervention group and 32in the control group who met the inclusion criteria of the study were included randomly.

Eligibility criteria: Inclusion Criteria:

* The mother and father are over 18 years old,
* Parents becoming parents for the first time,
* The newborn is healthy, born at term, with the mother and father,
* Parents' knowledge of Turkish,
* Mothers who accepted to participate in the study and received baby care training by participating in the pregnant class,
* Parents' willingness to participate in the research.

Exclusion Criteria:

* Having a baby born as a result of a risky pregnancy,
* The newborn is in intensive care,
* Presence of diagnosed psychiatric disease in the mother and father.

Primary outcomes:
measure: Edinburgh Postpartum Depression Scale
timeFrame: 5 months
Secondary outcomes:
measure: Postpartum Quality of Life Scale
timeFrame: 5 months
Other outcomes:
Locations:
city: Çorum
country: Turkey
facility: Fatma Yıldırım
Study officials:
References:
Clinical trial NCT05929989: Cystatin D Fibrinogen Like Protein 1
Official title: Role of Cystatin D and Fibrinogen Like Protein 1 in Rheumatoid Arthritis and Their Relation to Disease Activity
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Fibrinogen Like Protein 1
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-07-05
Enrollment: 86
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: adult patient diagnosed with rheumatoid arthrits

Brief summary: to detect role of cystatin D and fibrinogen like protein 1 in rheumatoid arthritis asses relationship between disease activity and cystatin D and fibrinogen like protein 1


Eligibility criteria: Inclusion Criteria:

* adult patient diagnosed for rheumatoid arthritis

Exclusion Criteria:

* patient with overlap syndrome indiviuals with other auto immune diseases

Primary outcomes:
measure: detect role of cystatin D and fibrinogen like protein 1
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Lin WW, Ho KW, Su HH, Fang TF, Tzou SC, Chen IJ, Lu YC, Chang MS, Tsai YC, Liu ES, Su YC, Wang YT, Cheng TL, Huang HK. Fibrinogen-Like Protein 1 Serves as an Anti-Inflammatory Agent for Collagen-Induced Arthritis Therapy in Mice. Front Immunol. 2021 Dec 16;12:767868. doi: 10.3389/fimmu.2021.767868. eCollection 2021.
citation: Scherer HU, Haupl T, Burmester GR. The etiology of rheumatoid arthritis. J Autoimmun. 2020 Jun;110:102400. doi: 10.1016/j.jaut.2019.102400. Epub 2020 Jan 22.
Clinical trial NCT01347489: Cronic Pressure Wounds and Relation With Gender
Official title: Cronic Pressure Wounds and Relation With Gender
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Wound
Keywords: gender
Lead sponsor: SB Istanbul Education and Research Hospital
Sponsor class: OTHER
First posted: 2011-05-04
Enrollment: 2
Sex: ALL
Minimum age (years): 17
Maximum age (years): 90
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cronic pressure wound patients

Brief summary: There is no exact scientfic data about gender relationship with cronic pressure wounds (CPW). This research is aimed first to reveal gender relationship with CPW and aimed secondarily to reveal the gender related couse(es).

Detailed description: There is no exact scientific data about gender relationship with cronic pressure wounds (CPW). Researches about this subject is generally related to prevention and management of the process. But gender difference is not exactly researched in the literature. This research is aimed first to reveal gender relationship with CPW and aimed secondarily to reveal the gender related couse(es).

Eligibility criteria: Inclusion Criteria:

* Cronic pressure wound patients

Exclusion Criteria:

* Operated cronic pressure wounds

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Bezmialem Vakif University
Study officials:
affiliation: Bezmialem Vakif University
name: erhan aysan, Assoc. Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03270189: Effect of the Visual Information Change in Functional Dystonia
Official title: Effect of the Visual Information Change in Functional Dystonia
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Dystonia
Dystonic Disorders
Torticollis
Movement Disorders
Central Nervous System Diseases
Nervous System Diseases
Dyskinesias
Neurologic Manifestations
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
First posted: 2017-09-01
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Maximum age (years): 71
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Cervical dystonia occurring only during the writing task is a rare form for which there is no established treatment. Many authors agree that alteration of sensory integration is associated with dystonia. Similar disturbances in the integration of oculomotor information could have a role in cervical dystonia forms involving visuo-cervico-manual coordination such as handwriting. We hypothesize that orthoptic treatment by wearing prisms when writing (i) will reduce the abnormal posture of the head occurring whilst writing and remove the associated nuchal pain; (ii) the correction after a period of systematic wearing of the prisms during handwriting tasks will have a sustainable effect allowing to keep a normal head position after the suppression of the prisms.


Eligibility criteria: Inclusion Criteria:

Case

* Presenting a cervical dystonia that occurs only during handwriting tasks, diagnosed by a neurologist specialised in movement disorders
* Being treated or not by injection of Botulinum Neurotoxin (but last injection \> 3 months before the initial assessment)

Control

* No cervical dystonia
* Same sex, age (± 5 years), socio-professional level and hand laterality as the cases

Exclusion Criteria:

Case

* Cervical dystonia occuring in other circumstances than handwriting
* Neurological disease other than cervical dystonia (e.g. Parkinson's syndrome)
* Pain, trauma or pathology of the cervical spine of another cause than cervical dystonia and which have required medical or surgical treatment in the last 6 months preceding the initial assessment

Control

* Cervical disorders requiring medical or surgical treatment in the last 6 months prior to the tests
* Neurological disease affecting the cervical region or the writing hand
* Uncorrected visual disorders

Primary outcomes:
measure: measure of head movement occurring when writing
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Fondation Ophtalmique Adolphe de Rothschild
Study officials:
affiliation: Fondation Ophtalmologique Adolphe de Rothschild
name: Jean-Pierre Bleton, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT06664489: Assessment of Knowledge, Attitude and Practice of Primary Care Doctors Towards Common Dermatologic Conditions in Sudan
Official title: Assessment of Knowledge, Attitude, and Practice of Primary Care Physicians Regarding Common Dermatologic Conditions in Sudan 2024: A Cross Sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dermatological Disorders
Keywords: Dermatological conditions
skin disorders
Attitude
Knowledge
Primary care physicians
Sudan
Lead sponsor: Research and Publication office
Sponsor class: OTHER
First posted: 2024-10-29
Enrollment: 178
Sex: ALL
Minimum age (years): 23
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Primary healthcare doctors working in primary care facilities in Sudan

Brief summary: The goal of this observational study is to assess the knowledge, attitude, and practice of primary care physicians regarding the common dermatologic conditions in Sudan. The main question it aims to answer is:

What is the level of knowledge of primary healthcare doctors regarding common dermatological conditions in Sudan? what is the attitude and practice of primary healthcare doctors regarding common dermatological conditions in Sudan?

Detailed description: Dermatological conditions represent a major global health burden and significant portion of primary healthcare visits. Primary healthcare physicians are the backbone of medical care and they are usually the first responders to deal with skin diseases. Therefore, it is essential for primary care doctors to possess the sufficient knowledge and the best practice to achieve the best possible outcomes. Assessing the knowledge, attitude and practice of doctors will help identify the areas of weakness and address the gaps.

Our online based cross-sectional study involved primary healthcare doctors across the 18 states of Sudan. The study utilized multistage sampling to select the participants to fill the online questionnaire that is intended to assess the knowledge of the participants using a photo quiz, the attitude using likert's scale based assessment and the practice.

the study explored the factors which may affect the knowledge attitude and practice of doctors like the age, sex, years of clinical experience, and number of cases seen per day.

Eligibility criteria: Inclusion Criteria:

* Primary care doctors above 23 years of age
* Work in primary healthcare settings in Sudan during the period of the study.

Exclusion Criteria:

* Doctors less than 23 years of age
* Not located in Sudan
* Didn't work in primary care facilities

Primary outcomes:
measure: Level of knowledge of common dermatological conditions in Sudan
timeFrame: April 2024 - September 2024
measure: Attitude of primary healthcare doctors regarding common dermatological conditions in Sudan
timeFrame: April 2024 - September 2024
Secondary outcomes:
Other outcomes:
Locations:
city: Khartoum
country: Sudan
facility: Research and Publication Office
Study officials:
References: