Clinical trial NCT04905186: Different Domains of Executive Function Dual Task Walking on Brain Activation and Gait Performance in Healthy Adults
Official title: The Effects of Different Domains of Executive Function Dual Task Walking on Brain Activation and Gait Performance in Healthy Adults
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Executive Function
Neurosciences
Keywords: executive function
dual task walking
difficulty level
brain activity
motor performance
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2021-05-27
Enrollment: 39
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population in this study are heathy adults.

Brief summary: The aim of this study is to investigate the effects of different domains of executive function (EF) during dual task walking condition on brain activation and gait performance in healthy adults. There are two experiments will be conducted in this study. Experiment 1 is a pilot study to determine the same level of difficulty in 3 EF domains, including inhibition, working memory and cognitive flexibility. Experiment 2 is carried out to investigate the effects of 3 different domains of EF which difficulties are controlled on gait performance and brain activation in dual task condition. 10 subjects will perform Stroop test (2s/3s/4s to change question), backward digit spans (3/4/5 digits) and naming test in Experiment 1. In Experiment 1, the primary outcome is the correct response speed (CRS) while secondary outcome will be the brain activity. In Experiment 2, 30 subjects will perform the single cognitive task A (SCTA, Stroop test), single cognitive task B (SCTB, backward digit spans), single cognitive task C (SCTC, naming test), single walking task (SWT), dual task A (DTA, walking while performing cognitive task A), dual task B (DTB, walking while performing cognitive task B) and dual task C (DTC, walking while performing cognitive task C). The CRS, gait performance, brain activity and the dual task costs (DTC) will be recorded in the Experiment 2. Brain activities in prefrontal cortex (PFC), premotor cortex (PMC) and supplementary motor area (SMAs) will be measured by functional near-infrared spectroscopy (fNIRS) during this study. One-way ANOVA with Tukey post-hoc test will be performed to establish the effect of different type of executive task on CRS or the brain activity. The differences of gait parameters and brain activity in different condition in the Experiment 2 will be examined by one-way ANOVA with repeated measured. Furthermore, the Pearson correlation coefficient will be used to examine the correlation of brain activation and executive function performance or gait parameters.


Eligibility criteria: Inclusion Criteria:

* 20-30 years (Experiment 1 \& 2)
* Mini-Mental State Examination (MMSE) score greater than 24 points (Experiment 1 \& 2)
* ability to walk 10 meters independently without an assistive device (Experiment 2)

Exclusion Criteria:

* any neurologic, orthopedic or psychological diseases (Experiment 1 \& 2)
* color vision deficiency (Experiment 1 \& 2)
* had the fall experiences within 6 months before the study (Experiment 2)

Primary outcomes:
measure: Experiment 1: Executive function performance- correct response speed (CRS)
timeFrame: Day 1
measure: Experiment 2: Executive function performance- correct response speed (CRS)
timeFrame: Day 1
measure: Experiment 2: walking performance- gait speed
timeFrame: Day 1
measure: Experiment 2: walking performance- cadence
timeFrame: Day 1
measure: Experiment 2: walking performance- stride length
timeFrame: Day 1
measure: Experiment 2: dual task performance- dual task costs(DTC) in mobility
timeFrame: Day 1
measure: Experiment 2: dual task performance- dual task costs(DTC) in executive function
timeFrame: Day 1
measure: Experiment 2: dual task performance- combine mean of dual task costs(DTC)
timeFrame: Day 1
Secondary outcomes:
measure: Experiment 1: Brain activation over prefrontal cortex
timeFrame: Day 1
measure: Experiment 1: Brain activities over supplementary motor area
timeFrame: Day 1
measure: Experiment 1: Brain activities over premotor cortex
timeFrame: Day 1
measure: Questionnaire in Chinese version
timeFrame: Day 1
measure: Experiment 2: Brain activities over prefrontal cortex
timeFrame: Day 1
measure: Experiment 2: Brain activities over supplementary motor area
timeFrame: Day 1
measure: Experiment 2: Brain activities over premotor cortex
timeFrame: Day 1
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
References: