Clinical trial NCT04479098: Effects of Training and Detraining on Postmenopausal Breast Cancer Survivors
Official title: Effects of Training and Detraining on Body Composition and Inflammatory, Oxidative and Lipid Profiles of Postmenopausal Breast Cancer Survivors Undergoing Tamoxifen Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Breast Neoplasm Female
Keywords: Breast Cancer
Immune function
Inflammation
Resistance exercise
Oxidative Stress
Menopause
Lead sponsor: Federal University of Uberlandia
Sponsor class: OTHER
First posted: 2020-07-21
Enrollment: 14
Sex: FEMALE
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The present study aimed to verify the effects of resistance exercise training and successive detraining on body composition, lipid profile, muscle strength, oxidative stress, and inflammatory markers of postmenopausal breast cancer survivors undergoing tamoxifen treatment.

Detailed description: The present study aimed to verify the effects of 12 weeks of resistance exercise training and successive 12 weeks of detraining on body composition (Body Mass, Body Mass Index, Fat Mass, and Fat-Free Mass), lipid profile (Triglycerides, Total Cholesterol, LDL-Cholesterol, HDL-Cholesterol), muscle strength (1RM test), oxidative stress (Thiobarbituric acid reactive substances,Non-Protein Thiols, Catalase activity, and Superoxide Dismutase), and inflammatory markers (Interferon γ, Tumor Necrosis Factor α, interleukin 6 , Adiponectin, and Interleukin 4) of postmenopausal breast cancer survivors undergoing tamoxifen treatment.

Eligibility criteria: Inclusion Criteria:

* 1) age between 40 and 65 years; 2) stage 0-IIIA Breast Cancer; 3) submission to axillary lymphadenectomy); 4) completion of chemotherapy and radiation therapy at least 6 months before the study; 5) lack of participation in supervised physical exercise programs in the six months before the beginning of the research; 6) absence of a problem and/or musculoskeletal limitation that would prevent the performance of the proposed exercises; 7) release by a medical professional to participate in the physical training program; 8) residency in Uberlândia

Exclusion Criteria:

* missing more than 20% of the exercise sessions; unable to perform the proposed training protocols; change in drug therapy during the intervention.

Primary outcomes:
measure: Changes in blood biomarkers (pg/mL)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/detraining
measure: Changes in blood biomarkers (mmol/L)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/detraining
measure: Changes in blood biomarkers (K/gHb.s)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/detraining
measure: Changes in blood biomarkers (U/gHb)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/detraining
measure: Changes in blood biomarkers (mg/dL)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/detraining
Secondary outcomes:
measure: Strength (kg)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/detraining
measure: Anthropometry (kg)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/detraining
measure: Anthropometry (%)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/detraining
measure: Anthropometry (kg/m²)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/detraining
Other outcomes:
Locations:
city: Uberlandia
country: Brazil
facility: Guilherme Morais Puga
state: Minas Gerais
Study officials:
References: