Clinical trial NCT02139163: Epidemiological Study on Community Acquired Pneumonia
Official title: Epidemiological Study on Community Acquired Pneumonia
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Community Acquired Pneumonia
Keywords: Community acquired pneumonia
CAP
CAPNETZ
age ≥18
infiltrate on chest X-ray
cough or production of purulent sputum
pathologic lung auscultation
fever
Lead sponsor: Hannover Medical School
Sponsor class: OTHER
First posted: 2014-05-15
Enrollment: 10150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with pneumonia

Brief summary: Long-term objectives of the basic research part are improvement of CAP-management with respect to therapy, diagnosis and prevention to contribute to a better care of patients with pneumonia.

Detailed description: Long-term objectives of the basic research part are improvement of CAP-management with respect to therapy, diagnosis and prevention to contribute to a better care of patients with pneumonia. The aim of the study CAPNETZ is to improve diagnosis, treatment and patient care.

Eligibility criteria: Inclusion Criteria:

* age ≥ 18
* infiltrate on chest X-ray
* further Inclusion criteria: cough or production of purulent sputum or pathologic lung auscultation (crackles) or fever

Exclusion Criteria:

* hospital inpatient treatment within the last 28 days
* Immune suppressed patients

Primary outcomes:
measure: diagnosis
timeFrame: 2 weeks
measure: therapy
timeFrame: 2 weeks
measure: hospitalization
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Hannover
country: Germany
facility: CAPNETZ FOUNDATION Hannover Medical School (MHH)
state: Niedersachsen
city: Hannover
country: Germany
facility: Hannover Medical School
state: Niedersachsen
Study officials:
affiliation: Hannover Medical School
name: Tobias Welte, Prof. Dr.
role: STUDY_CHAIR
References:
citation: Zobel K, Martus P, Pletz MW, Ewig S, Prediger M, Welte T, Buhling F; CAPNETZ study group. Interleukin 6, lipopolysaccharide-binding protein and interleukin 10 in the prediction of risk and etiologic patterns in patients with community-acquired pneumonia: results from the German competence network CAPNETZ. BMC Pulm Med. 2012 Feb 20;12:6. doi: 10.1186/1471-2466-12-6.
citation: Klapdor B, Ewig S, Schaberg T, Rohde G, Pletz MW, Schutte H, Welte T; CAPNETZ study group. Presentation, etiology and outcome of pneumonia in younger nursing home residents. J Infect. 2012 Jul;65(1):32-8. doi: 10.1016/j.jinf.2012.02.003. Epub 2012 Feb 10.
citation: Lepper PM, Ott S, Nuesch E, von Eynatten M, Schumann C, Pletz MW, Mealing NM, Welte T, Bauer TT, Suttorp N, Juni P, Bals R, Rohde G; German Community Acquired Pneumonia Competence Network. Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study. BMJ. 2012 May 28;344:e3397. doi: 10.1136/bmj.e3397.
citation: Kolditz M, Hoffken G, Martus P, Rohde G, Schutte H, Bals R, Suttorp N, Pletz MW; CAPNETZ study group. Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study. BMC Infect Dis. 2012 Apr 13;12:90. doi: 10.1186/1471-2334-12-90.
citation: Klapdor B, Ewig S, Pletz MW, Rohde G, Schutte H, Schaberg T, Welte T; CAPNETZ Study Group. Community-acquired pneumonia in younger patients is an entity on its own. Eur Respir J. 2012 May;39(5):1156-61. doi: 10.1183/09031936.00110911. Epub 2011 Nov 16.
citation: Ewig S, Klapdor B, Pletz MW, Rohde G, Schutte H, Schaberg T, Bauer TT, Welte T; CAPNETZ study group. Nursing-home-acquired pneumonia in Germany: an 8-year prospective multicentre study. Thorax. 2012 Feb;67(2):132-8. doi: 10.1136/thoraxjnl-2011-200630. Epub 2011 Nov 5.
citation: Glockner V, Pletz MW, Rohde G, Rupp J, Witzenrath M, Barten-Neiner G, Kolditz M; CAPNETZ Study Group. Early post-discharge mortality in CAP: frequency, risk factors and a prediction tool. Eur J Clin Microbiol Infect Dis. 2022 Apr;41(4):621-630. doi: 10.1007/s10096-022-04416-5. Epub 2022 Feb 8.