Clinical trial NCT03150069: Pregnancy With Morquio Syndrome - What Are Patients' Perspectives and Has ERT Changed Them?
Official title: Pregnancy With Morquio Syndrome - What Are Patients' Perspectives and Has ERT Changed Them?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Morquio Disease
MPS - Mucopolysaccharidosis
Keywords: Pregnancy
Lead sponsor: Emory University
Sponsor class: OTHER
Collaborators: name: BioMarin Pharmaceutical
First posted: 2017-05-11
Enrollment: 18
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women with Morquio syndrome, at least 15 years of age, English-speaking

Brief summary: The present study seeks to interview women with Morquio A and Morquio B syndrome, to explore their concerns surrounding pregnancy and the impact of ERT on their perspectives, in comparison with the control group of Morquio B subjects for whom no ERT treatment exists.

Interviews will be conducted by a health psychologist, in-person or over the telephone. Data will be analyzed using MAXQDA 12.0 software and Grounded Theory. Differences in thematic trends between Morquio A subjects, for whom treatment exists, and a control group of Morquio B subjects, for whom there is no treatment, will be compared.

Detailed description: The present study seeks to interview women with Morquio A and Morquio B syndrome themselves, to explore and discover their perspectives and concerns surrounding pregnancy and having biological children, the impact of the advent of ERT for Morquio A on their perspectives and concerns in comparison with the control group of Morquio B subjects for whom no ERT treatment exists, as well as what each group is being told by the medical community and others in their lives in this regard.

Interviews will be conducted by a health psychologist, either in-person or over the telephone. We will interview 1) those women with Morquio syndrome who are known to have been pregnant and 2) those women with Morquio syndrome who have not been pregnant and/or chose to adopt children. All information will be kept confidential, except as in accordance with Georgia law relating to reporting of child or elder abuse, suicidal and/or homicidal intent.

Data will be analyzed using MAXQDA 12.0 software to develop code which can be used to describe and compare the data using Grounded Theory. Differences in thematic trends between Morquio A subjects, for whom treatment exists, and a control group of Morquio B subjects, for whom there is no treatment, will be compared.

Eligibility criteria: Inclusion Criteria:

1. Documented clinical diagnosis of either MPS IVA or MPS IVB, based on clinical signs and symptoms, documented reduced fibroblast or leukocyte GALNS enzyme activity or genetic testing confirming diagnosis.
2. Subject is at least 15 years old.
3. Subject is female.
4. Subject is fluent enough in English to complete in-depth interview with PI.

Exclusion Criteria:

1. Patient has a clinically significant disease other than Morquio which would confound the effects of Morquio upon study variables.
2. Any condition that, in the view of the Investigator, places the patient at high risk of poor compliance or of not completing the study.

Primary outcomes:
measure: Completion of in-depth interview
timeFrame: Approximately 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Decatur
country: United States
facility: Emory University
state: Georgia
Study officials:
References: