louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01248767: A Prospective Clinical Study of a Cohort of Patients Seeking Treatment for a Behavioral Addiction
Official title: A Prospective Clinical Study of a Cohort of Pathological Patients Seeking Treatment for a Behavioral Addiction in the University Hospital of Nantes
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Behavioral Addictions
Keywords: cohort
cognitive distortions
impulsivity
psychiatric comorbidities
addiction
gambling disorder
sexual addiction
videogame disorder
food addiction
eating disorders
compulsive buying
behavioral addictions
Lead sponsor: Nantes University Hospital
Sponsor class: OTHER
First posted: 2010-11-25
Enrollment: 2720
Sex: ALL
Minimum age (years): 15
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients seeking treatment for a behavioral addiction

Brief summary: This research aims to provide a better understanding of the factors associated with the evolution of behavioral addictions, and compliance with care. The investigators thus aim to follow patients with several types of behavioral addictions, based on addictive, sociodemographic, clinical and endophenotypical characteristics, as well as their care adhesion.


Eligibility criteria: Inclusion Criteria :

- All consecutive patients seeking treatment at the University Hospital of Nantes for a behavioral addiction and age over 15 will be allowed to participate to the study.

Exclusion Criteria :

* Cognitive impairment incompatible with the assessment
* Difficulty for writing or reading the French language, incompatible with the assessement
* Gardianship

Primary outcomes:
measure: Evolution of behavioral addictions
timeFrame: 8 years
Secondary outcomes:
Other outcomes:
Locations:
city: Nantes
country: France
facility: Nantes University Hospital
Study officials:
affiliation: Nantes University Hospital
name: Marie GRALL-BRONNEC, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01979367: Physician Clinical Trial Policy (CTP) Neurological Ischemia Lower Extremity Pain and Swelling
Official title: To Evaluate the Efficacy Treatment of Lower Extremity Pathologies Derived From Neurological Ischemia Disorders
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Lower Extremity Swelling Acute
Lead sponsor: American Association of Sensory Electrodiagnostic Medicine
Sponsor class: INDUSTRY
First posted: 2013-11-08
Enrollment: 1000
Sex: ALL
Minimum age (years): 25
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Physician Clinical Trial Policy (CTP) to evaluate the efficacy treatment of lower extremity pathologies derived from neurological ischemia disorders using the combination of Monochromatic Infrared Photo Energy (MIRE) and Transcutaneous Electrical Nerve Stimulation (TENS) therapies.

Detailed description: Although there are a number of pain disorders, associated with back, or lower extremity pain and swelling, the American Association of Sensory Electrodiagnostic Medicine (AASEM/ DTSC) study programs will accumulate received data following a protocol of treatment performed for the purpose of eliminating pain, reducing swelling, and accelerating recovery periods as well as to record the success or failure and/or improvement of the malfunctioning body part.

* Condition: Neuropathic Pain, Tingling or Numbness derived from neurological Ischemia
* Intervention: Treatments of Monochromatic Infrared Photo Energy (MIRE) in combination with Electronic Signal Treatment (TENS) therapy
* Study Type: Interventional
* Study Design:

  1. Allocation: Non-Randomized
  2. Endpoint Classification: Efficacy Study
  3. Intervention Model: Single Group Assignment
  4. Masking: Open Label
  5. Primary Purpose: Scientific record of treatment success or failure

Eligibility criteria: Inclusion Criteria:

* In the investigator's judgment, a high probability of 5 year survival and compliance with the study visit schedule.

Ability to comprehend and sign an informed consent document prior to study enrollment.

Exclusion Criteria:

* Any other excluding factors that, according to the investigator's judgment, would preclude enrollment in the study.

Primary outcomes:
measure: Primary Outcome: Scientific record of treatment success or failure
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: American Association of Sensory Electrodiagnostic Medicine
name: Michael Boyer, M.D.
role: STUDY_DIRECTOR
affiliation: American Association of Sensory Electrodiagnostic Medicine
name: Chad Pfefer, M.D.
role: STUDY_CHAIR
References:
Clinical trial NCT02581267: Missed Serious Medical Illness in Psychiatric Patients Seen in an Academic Emergency Department
Official title: Missed Serious Medical Illness in Psychiatric Patients Seen in an Academic Emergency Department
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Emergency Services, Psychiatric
Lead sponsor: Western University, Canada
Sponsor class: OTHER
First posted: 2015-10-20
Enrollment: 800
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults emergency room patients referred to adult psychiatry by the emergency physician

Brief summary: Psychiatric presentations are common in the emergency department (ED), and determining whether or not a psychiatric presentation is due to medical illness can be a difficult task for the emergency physician. The investigators define "serious medical illness" (SMI) as a pathological condition that would necessitate inpatient treatment on a medical or surgical ward. It is important for patient safety that SMI be triaged by the emergency physician to the appropriate inpatient service. The rate of missed SMI in patients with psychiatric presentations to the ED is unknown. The investigators will research missed SMI in patients referred to adult psychiatry from the ED, with the intent to improve patient safety.


Eligibility criteria: Inclusion Criteria:

* All patients greater than or equal to 18 years of age presenting to London Health Sciences Centre, Victoria Hospital emergency department between October 1, 2014 - July 31, 2015 who were referred to adult psychiatry by the emergency physician.

Exclusion Criteria:

* None

Primary outcomes:
measure: Number of patients admitted to a medical / surgical service within 7 days of psychiatry referral in the emergency department
timeFrame: Approximately 8 months
measure: Medical / surgical admission diagnosis
timeFrame: Approximately 8 months
measure: Number of days after psychiatric referral that patient is admitted to medical / surgical service
timeFrame: Approximately 8 months
Secondary outcomes:
measure: Proportion of patients discharged home from the emergency department by psychiatry following referral by the emergency physician
timeFrame: Approximately 8 months
measure: Risk factors associated with medical / surgical admission after initial psychiatry referral
timeFrame: Approximately 8 months
measure: Number of admissions to medical / surgical service within 30 days of discharge from psychiatry
timeFrame: Approximately 8 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04116567: Lung Ultrasonography After Laparoscopic Gynecologic Surgery
Official title: Lung Ultrasonography for the Assessment of Perioperative Atelectasis After Laparoscopic Gynecologic Oncologic Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pulmonary Atelectasis
Keywords: Pulmonary Atelectasis
Lung Ultrasound
Laparoscopic Surgery
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2019-10-04
Enrollment: 80
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients \>18yo undergoing laparoscopy for ginecologic oncologic surgery willing to participate to the study

Brief summary: This study evaluates the influence of surgical and anesthesia-related variable on atelectasis formation during laparoscopic gynecologic oncologic surgery by lung ultrasound.

Detailed description: Approximately 50% of patients undergoing general anesthesia are hypoxemic. Anaesthesia, paralysis, high concentrations of oxygen, inadequate level of PEEP, capnoperitoneum, Trendelenburg position all result in persistent atelectasis. Lung ultrasound is a safe and accurate bedside tool useful to study lung aeration. The aim of the investigator's study was to assess the impact of general anesthesia and laparoscopic gynecologic oncologic surgery on post-operative atelectasis and related oxygenation changes using lung ultrasound.

Eligibility criteria: Inclusion Criteria:

* Patients older than 18 yo undergoing laparoscopic surgery for gynecologic surgery who provide written informed consent.

Exclusion Criteria:

* age \< 18 yo;
* pregnancy;
* refused to partecipate;
* known pulmonary metastasis;
* preexisting pulmonary conditions (COPD, pleural effusion, pulmonary consolidations, lung edema, pulmonary embolism);
* anesthesia with mechanical ventilation in the 2 weeks.

Primary outcomes:
measure: Assess if LUS score measured after surgery is higher that LUS score measured before induction of anesthesia
timeFrame: The outcome will be measured 10 minutes after extubation
measure: Correlation between the increase of LUS score after surgery and surgical or anesthesia-related variables.
timeFrame: The outcome will be measured 10 minutes after extubation
Secondary outcomes:
Other outcomes:
Locations:
city: Rome
country: Italy
facility: IRCCS Fondazione Policlinico Universitario Agostino Gemelli
Study officials:
affiliation: IRCCS Fondazione Universitaria Policlinico Agostino Gemelli
name: Luciano Frassanito, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: IRCCS Fondazione Universitaria Policlinico Agostino Gemelli
name: Gaetano Draisci, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01781767: Changes in Metabolic Status in Patients With Total Thyroidectomy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Thyroid Cancer
Keywords: UCP2
Thyroid function
Thyroid carcinoma
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2013-02-01
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who were diagnosed with thyroid carcinoma and are going throgh total thyroidectomy and recive a thyroid replacement therapy.

Brief summary: This study objective is to evaluate the change in mitochondrial uncoupling protein 2 (UCP2) mRNA expression as function of thyroid activity (TSH, T3 and Free T4).

Detailed description: Blood will be drown before thyroidectomy, 2 weeks after the operation and 3-4 month after the operation.

Eligibility criteria: Inclusion Criteria:

* Patients who were diagnosed with thyroid carcinoma and are going to have total thyroidectomy.
* Patients with unbalanced thyroid hormones.
* Aged 18-65 years at the time of screening.
* Provision of written informed consent.

Exclusion Criteria:

* Patients with Diabetes.
* Patients with any other chronic inflammatory diseases.
* Steroid treatment.

Primary outcomes:
measure: Changes in UCP2 mRNA concentrations.
timeFrame: Base line (before opporation), 2 weeks after opporation and for after opporation.
Secondary outcomes:
measure: Weight
timeFrame: Approximately 4 months
measure: Resting energy expenditure
timeFrame: Approximatly 4 months
Other outcomes:
Locations:
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center
Study officials:
References:
citation: Yen PM. Physiological and molecular basis of thyroid hormone action. Physiol Rev. 2001 Jul;81(3):1097-142. doi: 10.1152/physrev.2001.81.3.1097.
citation: Schwartz HL, Oppenheimer JH. Physiologic and biochemical actions of thyroid hormone. Pharmacol Ther B. 1978;3(3):349-76. doi: 10.1016/s0306-039x(78)80002-6. No abstract available.
citation: Brand MD, Esteves TC. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2005 Aug;2(2):85-93. doi: 10.1016/j.cmet.2005.06.002.
citation: Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev. 1984 Jan;64(1):1-64. doi: 10.1152/physrev.1984.64.1.1. No abstract available.
citation: Gjedde S, Gormsen LC, Riis AL, Jorgensen JO, Rungby J, Moller N, Weeke J, Pedersen SB. Reduced expression of uncoupling protein 2 in adipose tissue in patients with hypothyroidism. J Clin Endocrinol Metab. 2010 Jul;95(7):3537-41. doi: 10.1210/jc.2009-0907. Epub 2010 Apr 28.
Clinical trial NCT01255267: The Correlation Between Genetic Polymorphism, Platelet Activity, Clopidogrel Responsiveness, and Serum Adipokine Concentration in Asian Acute Coronary Syndrome Patients
Official title: The Correlation Between Genetic Polymorphism, Platelet Activity, , Clopidogrel Responsiveness, and Serum Adipokine Concentration in Asian Acute Coronary Syndrome Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Coronary Syndrome
Chronic Coronary Artery Disease
Keywords: Acute coronary syndrome and chronic coronary artery disease patients
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2010-12-07
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Acute coronary syndrome and chronic coronary artery diseae patients

Brief summary: In this study, we evaluate the acute coronary syndrome patients to see if there is correlation between platelet activity, genetic polymorphism (CYP2C19 and ABCB1), serum adipokines level, and Clopidogrel responsiveness.


Eligibility criteria: Inclusion Criteria:

1. Age \> 18 y/o
2. Acute coronary syndrome patients
3. Chronic coronary artery disease patients
4. Healthy volunteers

Exclusion Criteria:

1. Patient refusal
2. Allergy to Clopidogrel
3. Receive Gp IIb/IIIa inhibitor simultaneously
4. Cancer history
5. Severe renal and liver function impairment
6. Coagulopathy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: China Medical University Hospital
Study officials:
References:
Clinical trial NCT00795067: Relation of Circulating Endothelium-derived Microparticle to Carotid Atherosclerosis
Official title: Relation of Circulating Endothelium-derived Microparticle to Carotid Atherosclerosis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Atherosclerosis
Lead sponsor: Kurume University
Sponsor class: OTHER
First posted: 2008-11-21
Enrollment: 154
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who undergo carotid ultrasound examination for screening of atheroscrelosis

Brief summary: The investigators hypothesized that circulating endothelium-derived microparticle (EMP) may be a useful surrogate marker of atherosclerosis and future episode of cerebrovascular events. Peripheral blood is drawn at the time of carotid ultrasound examination. Circulating EMPs are counted using flow-cytometry. The correlation among circulating EMP, ultrasound findings, and atherosclerotic risk factors are determined by multiple stepwise regression analysis. The prevalence of cerebrovascular events is also determined during 3-year follow-up period.


Eligibility criteria: Inclusion Criteria:

* Patients who undergo carotid ultrasound examination for screening of atherosclerosis

Exclusion Criteria:

* Cerebrovascular events within the last 12 months
* Acute coronary syndrome, coronary and peripheral intervention within the last 6 months
* Uncontrolled heart failure
* Other severe systemic diseases

Primary outcomes:
measure: The number of circulating EMPs
timeFrame: at the time of carotid ultrasound examination
Secondary outcomes:
measure: The occurrence of cerebrovascular and/or cardiovascular events
timeFrame: 3 years
Other outcomes:
Locations:
city: Kurume
country: Japan
facility: Kurume University Hospital
state: Fukuoka
Study officials:
affiliation: Kurume University
name: Tsutomu Imaizumi, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT02997267: Early Closure of Protective Ileostomy in Rectal Cancer Patients
Official title: The Early Closure of the Protective Ileostomy After Low Anterior Resection Enables Correct Start of Chemotherapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ileostomy - Stoma
Lead sponsor: Stanley Dudrick's Memorial Hospital
Sponsor class: OTHER
First posted: 2016-12-20
Enrollment: 58
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study was to compare the restoration of the GI tract by the closure of protective ileostomy after low anterior resection for rectal cancer after 14 days and more than 3 months.

Detailed description: The closure of the protective ileostomy created during the low anterior resection for rectal cancer to protect the colo-rectal anastomosis is inevitable to restore the continuity of the gastrointestinal tract. It usually takes place several months after the primary surgery, because the patients starts chemotherapy and cannot undergo the procedure during the therapy. It results in the relative low quality of life of the patient, as well as often leads to complications. Therefore, it seem reasonable to close the stoma as soon as possible to take the burden off patient.

It is well known that the healing process of the anastomosis runs in the three phases, but only two first are crucial for the clinical result. The second takes place between 5th and 14th postoperative day. Therefore it should be possible to perform successful restoration of the GI tract already after two weeks after operation, and not after many moths.

The aim of the study was to compare the restoration of the GI tract after 14 days and more than 3 months, so to compare the traditional and early strategy.

Eligibility criteria: Inclusion Criteria:

* more than 18 year old
* the presence of the protective ileostomy created during the low anterior resection to protect the colo-rectal anastomosis

Exclusion Criteria:

* the presence of the protective ileostomy created during any other procedure than the low anterior resection to protect the colo-rectal anastomosis
* age \< 18 yo

Primary outcomes:
measure: Number of postoperative fistulas
timeFrame: 3 months after surgery
Secondary outcomes:
measure: Timing of anticancer therapy
timeFrame: 3 months after surgery
Other outcomes:
Locations:
city: Skawina
country: Poland
facility: Stanley Dudrick's Memorial Hospital
Study officials:
References:
Clinical trial NCT06412367: FUNCTIONAL ASSESSMENT FOR SURGERY BY A TIMED WALK
Official title: FUNCTIONAL ASSESSMENT FOR SURGERY BY A TIMED WALK
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Surgery-Complications
Postoperative Complications
Keywords: Six Minute Walk Test
Functional assessment
Lead sponsor: Unity Health Toronto
Sponsor class: OTHER
Collaborators: name: Canadian Institutes of Health Research (CIHR)
name: The Physicians' Services Incorporated Foundation
First posted: 2024-05-14
Enrollment: 1672
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The sample will include adults who warrant preoperative risk assessment for inpatient non-cardiac surgery. To identify patients at elevated risk for complications, participants must be aged ≥40 y and have ≥1 risk factor for postoperative complications.

Brief summary: The FAST Walk study aims to determine whether a walking test called the 6-minute walk test (6MWT) can help identify people who are more likely to experience complications after surgery. This test will be completed before surgery. We hope that the results of this study will help improve care for patients having major surgery in the future.


Eligibility criteria: Inclusion Criteria:

1. Age ≥40 years
2. ≥1 risk factors for postoperative complications
3. Elective non-cardiac surgery with expected post-surgery stay ≥2 days
4. Preoperative 6MWT is feasible
5. Working knowledge of official language(s) in country of study recruitment

Exclusion Criteria:

1. Endovascular surgery
2. Lower limb orthopedic surgery
3. Contraindications to 6MWT

Primary outcomes:
measure: Postoperative complications
timeFrame: 30 days after surgery
Secondary outcomes:
measure: Days alive and out of the hospital
timeFrame: 30 days after surgery
measure: Significant new disability
timeFrame: 90 days after surgery
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: St. Michael's Hospital
state: Ontario
Study officials:
affiliation: Unity Health Toronto
name: Duminda N Wijeysundera, MD PhD FRCPC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02009267: Nuss Procedure: Clinical Options in Pediatric Pain Management?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pectus Excavatum
Lead sponsor: Nationwide Children's Hospital
Sponsor class: OTHER
First posted: 2013-12-11
Enrollment: 32
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing the Nuss procedure to correct pectus excavatum at Nationwide Children's Hospital.

Brief summary: A retrospective chart review study analyzing the benefits of patient controlled analgesia, thoracic epidural analgesia, and paravertebral nerve block catheters in patients having surgical repair of pectus excavatum using the Nuss procedure.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing the NUSS procedure since the beginning of 2011 to Sept. 30th, 2013.

Exclusion Criteria:

* None

Primary outcomes:
measure: Total morphine dose
timeFrame: Participants will be followed for the duration of hospital stay, an expected average of 3 days
Secondary outcomes:
measure: Pain score
timeFrame: Participants will be followed for the duration of hospital stay, an expected average of 3 days
measure: Length of hospitalization
timeFrame: Within the first week after surgery.
measure: Nausea and vomiting
timeFrame: 0-48 hrs. post-op
Other outcomes:
Locations:
city: Columbus
country: United States
facility: Nationwide Children's Hospital
state: Ohio
Study officials:
affiliation: Nationwide Children's Hospital
name: Beltran Ralph, MD
role: PRINCIPAL_INVESTIGATOR
References: