Clinical trial NCT05369169: Afferent Neurocardiac Signals, Cue Reactivity, and Cognitive Control
Official title: Afferent Neurocardiac Signals, Cue Reactivity, and Cognitive Control
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Binge Drinking
Keywords: Alcohol Consumption
Baroreflex
Arousal
Breathing
Cardiovascular System
Cognition
Electrophysiology
Event-Related Potentials
Heavy Drinking
Attention
Individual Differences
Alcohol Cue
Brief Intervention
Cognitive Control
Cue Reactivity
Drinking Behavior
Young Adult
Heart Rate Variability
Lead sponsor: Rutgers, The State University of New Jersey
Sponsor class: OTHER
First posted: 2022-05-11
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Subjects will complete an active treatment of slow resonance paced breathing and a control visual color block task on separate days, separated by approximately one week
Primary purpose: BASIC_SCIENCE

Brief summary: Conscious attempts to regulate alcohol use are often undermined by automatic attention and arousal processes activated by alcohol cues, as well as by diminished ability to inhibit in-the-moment behaviors. The current study will examine whether a brief behavioral intervention of slow breathing paced at a resonance frequency of the cardiovascular system can interrupt automatic alcohol cue reactivity and enhance cognitive control in binge drinkers. Results from the proposed study may provide new prevention and intervention targets to interrupt unhealthy drinking behaviors.


Eligibility criteria: Inclusion Criteria:

* Must report at least 2 binge drinking episodes in the past month
* Have normal or corrected-to-normal vision

Exclusion Criteria:

* History or presence of serious psychiatric disorders, neurological disorders, or head injury resulting in a loss of consciousness
* Presence of any serious medical condition
* Report of more than a few occasions (3-4) of illicit drug use, except for cannabis, in the preceding year

Primary outcomes:
measure: N2 ERP amplitude (in microvolts) elicited from an Alcohol Cued Go/No-Go task
timeFrame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
measure: N2pc ERP amplitude (in microvolts) elicited from a visual dot probe detection task
timeFrame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
measure: P3b ERP amplitude (in microvolts) elicited from a picture-viewing task
timeFrame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
measure: N2 ERP latency (in milliseconds) elicited from an Alcohol Cued Go/No-Go task
timeFrame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
measure: N2pc ERP latency (in milliseconds) elicited from a visual dot probe detection task
timeFrame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
measure: P3b ERP latency (in milliseconds) elicited from a picture-viewing task
timeFrame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
measure: Task accuracy from the behavioral response during the Alcohol Cued Go/No-Go task
timeFrame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
measure: Reaction time from the behavioral response during the Alcohol Cued Go/No-Go task
timeFrame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
measure: Task accuracy from the behavioral response during the visual dot probe detection task
timeFrame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
measure: Reaction time from the behavioral response during the visual dot probe detection task
timeFrame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
Secondary outcomes:
Other outcomes:
Locations:
city: New Brunswick
country: United States
facility: Rutgers, The State University of New Jersey
state: New Jersey
Study officials:
affiliation: Rutgers, The State University of New Jersey
name: Brandon L Alderman, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Rutgers, The State University of New Jersey
name: Marsha E Bates, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: