Clinical trial NCT06440863: Postoperative BMI Changes and Functional Outcomes in Knee and Hip Arthroplasty
Official title: The Effect of Changes in Body Mass Index After Total Knee and Hip Arthroplasty on Patient Functional Scores
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Arthropathy
Obesity
Keywords: Total Hip Arthroplasty
Total Knee Arthroplasty
Weight Loss
Obesity
Body Mass Index
Lead sponsor: Istanbul University - Cerrahpasa
Sponsor class: OTHER
First posted: 2024-06-04
Enrollment: 459
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: PURPOSE Obesity poses challenges to preoperative mobility and functional recovery for arthroplasty patients, yet postoperative weight loss remains elusive. This study aims to investigate postoperative weight changes and their impact on functional scores following knee and hip arthroplasty, exploring factors influencing these changes.

METHODS A total of 459 knee and hip arthroplasty cases with a 2-year follow-up were analyzed. BMI and Oxford scores were tracked, alongside factors including comorbidities, corticosteroid use, physiotherapy, and unilateral vs. bilateral surgery.

EXPECTED OUTCOMES Based on the study's design and the data available, we anticipate observing the impact of changes in patients' BMI on clinical scores as an independent variable. Additionally, we aim to elucidate the effects of comorbidities, corticosteroid use, physiatrist follow-up, and the type of surgical procedure on both BMI and clinical outcomes. Through this analysis, we expect to gain a comprehensive understanding of how these factors interplay to influence postoperative recovery and overall patient health.


Eligibility criteria: Inclusion Criteria:

* Patients who underwent primary TKA and THA with a 2-year follow-up were included

Exclusion Criteria:

* Patients who underwent bariatric surgery before or after the surgery
* Incomplete 2-year follow-up
* Whom BMI or Oxford scores could not be accessed

Primary outcomes:
measure: BMI
timeFrame: 2 years
measure: Oxford hip and knee scores
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul University - Cerrahpasa, Cerrahpasa Faculty of Medicine
state: Fatih
Study officials:
affiliation: Istanbul University - Cerrahpasa
name: Cumhur Deniz Davulcu
role: PRINCIPAL_INVESTIGATOR
References:
citation: Woodruff MJ, Stone MH. Comparison of weight changes after total hip or knee arthroplasty. J Arthroplasty. 2001 Jan;16(1):22-4. doi: 10.1054/arth.2001.9826.
citation: Riddle DL, Singh JA, Harmsen WS, Schleck CD, Lewallen DG. Clinically important body weight gain following knee arthroplasty: a five-year comparative cohort study. Arthritis Care Res (Hoboken). 2013 May;65(5):669-77. doi: 10.1002/acr.21880.
citation: Inacio MC, Silverstein DK, Raman R, Macera CA, Nichols JF, Shaffer RA, Fithian D. Weight patterns before and after total joint arthroplasty and characteristics associated with weight change. Perm J. 2014 Winter;18(1):25-31. doi: 10.7812/TPP/13-082.