Clinical trial NCT06889116: VExUS Score and AKI in Critically Ill Adult patients-a Prospective Observational Study.
Official title: Correlation of Point of Care Venous Excess Ultrasonography (VExUS) Score and Acute Kidney Injury (AKI) in Critically Ill Adult Patients- a Prospective Observational Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Kidney Injury
VExUS
Keywords: VExUS
Acute Kidney Injury
Cumulative fluid balance
Point of Care Ultrasound
Lead sponsor: Tribhuvan University Teaching Hospital, Institute Of Medicine.
Sponsor class: OTHER
First posted: 2025-03-21
Enrollment: 52
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who had AKI at the time of admission or who developed AKI during their ICU stay were screened for inclusion.

Brief summary: Introduction Renal perfusion is dependent on the renal perfusion pressure across the renal capillaries. Venous congestion due to excess fluid therapy can drastically reduce the renal perfusion pressure in spite of a normal mean arterial pressure. Increasing cumulative fluid balance during the ICU stay has been found to be associated with negative outcomes including acute kidney injury (AKI) and hospital mortality. Venous excess ultrasound (VExUS) to assess the Doppler studies of renal, hepatic and portal veins along with the inferior venacava has been shown to reliably predict the incidence of AKI in certain ICU patient population more specifically in cardiorenal syndrome. The aim of this study was to correlate the incidence of AKI and VExUS scores in a mixed ICU population and hence determine the contribution of venous congestion on the causation of AKI in a general ICU.

Methods:

The patients included who have AKI at admission or developed AKI during their ICU stay were included. The definition of AKI used for this study was as defined by Kidney Disease: Improving Global Outcomes (KDIGO). Point of care VExUS scans were done on each patient at inclusion (day 0), then each day for a total of 4 days (day 1, 2 and 3), till initiation of renal replacement therapy, death or discharge form the ICU. Correlation between VExUS grades and creatinine clearances was explored as the primary objective.


Eligibility criteria: Inclusion Criteria:

* Age ≥18 years
* Admitted to the adult ICUs of TUTH (ICU A and ICU B)
* Admitting diagnosis of AKI or who developed AKI during their ICU stay

Exclusion Criteria:

* Pregnancy
* Diagnosed case of chronic kidney disease
* Diagnosed case of cirrhosis/ portal hypertension
* Arrhythmias which would interfere with the acquisition and interpretation of the Doppler waveforms
* Inferior venacava thrombus
* Poor window for assessment

Primary outcomes:
measure: To determine correlation between the VExUS score with creatinine clearance.
timeFrame: At the end of Day 3 or initiation of renal replacement therapy or resolution of AKI, death or discharge from the ICU. whichever came first.
Secondary outcomes:
Other outcomes:
Locations:
city: Maharajganj
country: Nepal
facility: Tribhuvan University Teaching Hospital
state: Bagmati
Study officials:
References: