Clinical trial NCT06241274: Moxibustion in the Treatment of Hemorrhagic Cystitis After Allo-HSCT
Official title: Clinical Study of Moxibustion in the Treatment of Hemorrhagic Cystitis After Allogeneic Hematopoietic Stem Cell Transplantation
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Moxibustion
Hematopoietic Stem Cell Transplantation
Hemorrhagic Cystitis
Treatment
Lead sponsor: Wuhan Union Hospital, China
Sponsor class: OTHER
First posted: 2024-02-05
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study was a prospective, multicenter, single-arm clinical study planned to enroll 60 patients who developed hemorrhagic cystitis after sexually allogeneic hematopoietic stem cell transplantation Patients with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation were given symptomatic supportive treatment combined with moxibustion covering Shenque, Zhongguo, Guanyuan, and Qihai for 30 minutes every day for 14 days and urine routine was collected every day for 14 days to assess the severity of hemorrhagic cystitis and pain scores to evaluate the effectiveness of moxibustion in treating hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.


Eligibility criteria: Inclusion Criteria:

1. patients were fully aware of the study, participated voluntarily, and signed the informed consent form;
2. Age: 18-55 years old;
3. patients with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation;

Exclusion Criteria:

1. refusal to participate in this clinical study;
2. broken or sensitized skin corresponding to the moxibustion site;
3. allogeneic hematopoietic stem cell transplantationpatients pretreated with the Reduced-intensity conditioning.

Primary outcomes:
measure: Core Lower Urinary Tract Symptom Score
timeFrame: 14 days
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Yi Zhang
state: Hubei
Study officials:
References:
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citation: Hassan Z, Remberger M, Svenberg P, Elbander M, Omazic B, Mattsson J, Conrad R, Svahn BM, Ahlgren A, Sairafi D, Aschan J, Le Blanc K, Barkholt L, Ringden O. Hemorrhagic cystitis: a retrospective single-center survey. Clin Transplant. 2007 Sep-Oct;21(5):659-67. doi: 10.1111/j.1399-0012.2007.00705.x.
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