Clinical trial NCT02026596: SpareBrain - Mechanisms and Prevention of Secondary Brain Injury in Subarachnoid Haemorrhage
Official title: Observational Study on Mechanisms and Prevention of Secondary Brain Injury in Subarachnoid Haemorrhage
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aneurysmal Subarachnoid Hemorrhage
Keywords: subrachnoid hemorrhage
secondary brain injury
Lead sponsor: Tampere University Hospital
Sponsor class: OTHER
First posted: 2014-01-03
Enrollment: 61
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients suffering from aneurysmal subarachnoid haemorrhage

Brief summary: Subarachnoidal hemorrhage (SAH) is a cause of long-term disability and death. Annually about 1000 people in Finland suffer from SAH, their average age being under 50 years. SAH has a mortality rate of 12 % acutely and 40 % of patients die within a month from admission to hospital. In addition, 30 % of the surviving patients remain with neurological deficits. Most survivors of the primary insult suffer from secondary injury during the first 2-3 weeks from the insult.

Despite the advances in neurosurgical and -radiological techniques and intensive care, the mortality and morbidity rates in SAH have not changed in recent years. There is still only limited understanding of the mechanisms of secondary insults causing brain injury after SAH.

In this study the investigators are aiming to clarify the timescale and mechanisms contributing to the secondary insults. The investigators also explore usability of novel biomarkers to guide treatment of the patients suffering from SAH.

Detailed description: Subarachnoidal hemorrhage (SAH) is a cause of long-term disability and death. Annually about 1000 people in Finland suffer from SAH, their average age being under 50 years. SAH has a mortality rate of 12 % acutely and 40 % of patients die within a month from admission to hospital. In addition, 30 % of the surviving patients remain with neurological deficits. Most survivors of the primary insult suffer from secondary injury during the first 2-3 weeks from the insult.

Despite the advances in neurosurgical and -radiological techniques and intensive care, the mortality and morbidity rates in SAH have not changed in recent years. There is still only limited understanding of the mechanisms of secondary insults causing brain injury after SAH.

In this study the investigators are aiming to clarify the timescale and mechanisms contributing to the secondary insults. The investigators also explore usability of novel biomarkers to guide treatment of the patients suffering from SAH.

Eligibility criteria: Inclusion Criteria:

* aneurysmal subarachnoid haemorrhage

Exclusion Criteria:

* age under 18 years
* pregnant
* moribund patient

Primary outcomes:
measure: Neuroradiologically confirmed secondary injury lesions
timeFrame: up to 2 weeks after the primary insult
Secondary outcomes:
measure: Neurological outcome of the patient
timeFrame: 6 months
Other outcomes:
Locations:
city: Tampere
country: Finland
facility: Tampere University Hospital
state: Länsi-Suomen lääni
Study officials:
References: