Clinical trial NCT05645289: Efficacy and Safety of Minodronate in Patients With Low Back Pain
Official title: Efficacy and Safety of Minodronate in the Treatment of Postmenopausal Osteoporosis With Low Back Pain: a Single-centre and Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Postmenopausal Osteoporosis
Keywords: minodronate
low back pain
adverse reactions
pharmacokinetic
pharmacodynamic
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2022-12-09
Enrollment: 72
Sex: FEMALE
Minimum age (years): 55
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will provide objective evidence for the efficiency and safety of minodronate in the treatment of postmenopausal osteoporosis with low back pain protocol. Furthermore, it will be helpful to evaluate the quantitative relationship between bone metabolic markers (BTM) and bone mineral density (BMD) in patients with osteoporosis under different ages.

Detailed description: The study is a randomized, parallel controlled clinical trial in Chinese postmenopausal OP patients receiving minodronate or alendronate. Minodronate will be administered once daily for 12 weeks, and alendronate will be administered once daily for 12 weeks. This study is divided into two stages: the first stage is 12 weeks, and at the end of the first stage, the results of patients' back pain and gastrointestinal adverse reactions will be summarized; the second stage is 12 weeks, and the pharmacokinetic and pharmacodynamic characteristics of patients will be summarized at the end of the second stage. The VAS score in this study rangs from 0-100 mm. During the screening, the patient's past pain relief methods, such as pain medication or the way of life intervention will be recorded. The use of the above methods during the patients' treatment will be prohibited to prevent interference with the results of the clinical trials. During the treatment, if patients experience sudden aggravation of low back pain, the VAS score is more than 70, and the patients could not bear the pain, a rescue drug (acetaminophen) will be used uniformly to relieve the pain. Throughout the trial, a total of 5 follow-up visits will be planned. The VAS score, PK\&PD sampling, BMD evaluation, and Izumo scale score will be calculated.

Eligibility criteria: Inclusion Criteria:

1. Chinese postmenopausal patients with a diagnosis of OP;
2. Patients with low back pain of at least 3 months and a VAS score ≥30;
3. The value of lumbar L1-4 or total hip bone density measured by DXA is \< -2.5;
4. Serum 25-hydroxyvitamin D (25-OHD) concentration ≥20 ng/mL;
5. Patients with full capacity for civil conduct and understanding of the research process and methods voluntarily participated in this study and signed the informed consent form.

Exclusion Criteria:

1. Patient who are allergic to minodronate, alendronate, or other bisphosphonate drug or any other component of the drug under evaluation;
2. Patients with a diagnosis of secondary OP;
3. The following drugs affecting bone metabolism were used before the screening:

   Received injections of bisphosphonate and denosumab within 3 years; Received oral bisphosphonate, parathyroid hormones or analogues, strontium, or fluoride within 6 months; Received glucocorticoids, steroids, immunosuppressants, calcitonin, calcitriol or its analogues, thiazide diuretics, and ng-acting oestrogen/progesterone replacement therapy within 3 months;
4. Patients with a diagnosis of diseases affecting bone metabolism (e.g., osteogenesis imperfecta, malignancy, progressive diaphyseal dysplasia, Paget's disease, rheumatoid arthritis, osteosclerosis, osteoporosis with a slipped disc and spinal stenosis, and liver and kidney failure);
5. Patients are participating or have participated in an investigational drug study within 3 months before signing the informed consent form;
6. Patients under 75 years old with a creatinine clearance rate \< 60 mL/min and those \> 75 years old with a creatinine clearance rate \< 45 mL/min;
7. Serum calcium levels \< 2.0 mmol/L (8 mg/dL) or \> 2.7 mmol/L (11.0 mg/dL);
8. Patients with fever, severe infection, severe trauma, or major surgery within 30 days;
9. Patients with a QTc interval of \> 480 ms;
10. Patients are undergoing or planning to undergo invasive dental treatment;
11. Smoking history in the past six months;
12. Patients with a history of alcohol abuse (\> 15 g of alcohol per day, equivalent to 350 mL of beer or 150 mL of wine, more than twice per week) and drug abuse;
13. Patients with a prior history of cerebral infarction, ischaemic or haemorrhagic stroke;
14. Patients with implants and/or fractures in the lumbar spine or hip that interfere with BMD testing;
15. Received pain relievers (e.g., nonsteroidal anti-inflammatory drugs, central analgesics) or life interventions to relieve pain within 1 week before screening;

Primary outcomes:
measure: The time for a 10 point decrease in the VAS score within 24 weeks
timeFrame: up to 24 weeks
Secondary outcomes:
measure: Concentration in plasma of minodronate and alendronate on the first day before administration
timeFrame: on the first day before administration
measure: Concentration in plasma of minodronate and alendronate on the 8th week after administration
timeFrame: on the 8th week after administration
measure: Concentration in plasma of minodronate and alendronate on the 12th week after administration
timeFrame: on the 12th week after administration
measure: Concentration in plasma of minodronate and alendronate on the 24th week after administration
timeFrame: on the 24th week after administration
measure: Maximum concentration of minodronate and alendronate within 24 weeks
timeFrame: 0-24 weeks
measure: AUC of minodronate and alendronate within 24 weeks
timeFrame: 0-24 weeks
measure: Apparent clearance of minodronate and alendronate within 24 weeks
timeFrame: 0-24 weeks
measure: The pharmacodynamic of minodronate and alendronate on the first day before administration
timeFrame: on the first day before administration
measure: The pharmacodynamic of minodronate and alendronate on the 12th week after administration
timeFrame: on the12th week after administration
measure: The pharmacodynamic of minodronate and alendronate on the 24th week after administration
timeFrame: on the 24th week after administration
measure: The incidence of upper gastrointestinal symptoms
timeFrame: 0-24 weeks
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University Third Hospital
state: Beijing
Study officials:
affiliation: Peking University Third Hospital
name: Chunli Song, Pro.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yoshioka T, Okimoto N, Okamoto K, Sakai A. A comparative study of the effects of daily minodronate and weekly alendronate on upper gastrointestinal symptoms, bone resorption, and back pain in postmenopausal osteoporosis patients. J Bone Miner Metab. 2013 Mar;31(2):153-60. doi: 10.1007/s00774-012-0393-x. Epub 2012 Oct 19.