louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01997424: Association of Non-alcoholic Fatty Liver Disease and Diabetes Mellitus
Official title: Association of Non-alcoholic Fatty Liver Disease and Diabetes Mellitus
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Non-alcoholic Fatty Liver Disease (NAFLD)
Lead sponsor: Johann Wolfgang Goethe University Hospital
Sponsor class: OTHER
First posted: 2013-11-28
Enrollment: 340
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This study will evaluate the association of non-alcoholic fatty liver disease and diabetes mellitus. Patients presenting in our clinic with Diabetes mellitus type 1 or 2 will receive the following examination:

* Transient Elastography and Controlled Attenuation Parameter using the FibroScan
* blood examination including biochemical markers The statistically calculated sample size needed is 340 patients.


Eligibility criteria: Inclusion Criteria:

* Male or female, 18 years and older
* Written informed consent
* Diabetes mellitus type 1 or 2

Exclusion Criteria:

* Patients with mental diseases
* Pregnancy or lactation
* Ascites
* Continued alcohol consumption (\> 21 drinks/week for male and \> 14 drinks/week for female patients)
* Chronic liver disease (viral hepatitis, autoimmune hepatitis, PBC, PSC, hemochromatosis, M Wilson)
* Hepatocellular carcinoma/ Liver metastasis

Primary outcomes:
measure: Steatosis
timeFrame: one day
Secondary outcomes:
measure: Fibrosis
timeFrame: one day
measure: Steatosis (serum)
timeFrame: one day
Other outcomes:
Locations:
city: Frankfurt am Main
country: Germany
facility: University Hospital Frankfurt
state: Hessen
Study officials:
affiliation: Goethe University
name: Mireen Friedrich-Rust, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06769724: Anthropometric Predictability of Full-Thickness Peroneus Longus and Semitendinosus Autograft Size
Official title: Anthropometric Predictability of Full-Thickness Peroneus Longus and Semitendinosus Autograft Size: A Comparative Analysis
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Anterior Cruciate Ligaments
Keywords: Anterior Cruciate Ligaments
peroneus longus tendon
semitendinosus tendon
anthropometric
Lead sponsor: Karadeniz Technical University
Sponsor class: OTHER
First posted: 2025-01-10
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who will apply to our center due to ACL ligament injury and will be decided to undergo surgical treatment will be included in the study if they volunteer to participate.

Brief summary: The study is aimed to determine correlation between autografts used in anterior cruciate ligaments and anthropometric variables e.g. height, sex, weight, BMI etc..

Detailed description: Categorical data: Age, Sex, Height, Weight, BMI, Preoperative parameters: cruris length, cruris circumference, thigh length, thigh circumference Intraoperative Info: Tendon Type, Tendon length (total-muscular part-tendinoz part), Graft Length, Graft Diameter.

After the data collected, correlation analysis will be held and determine the both tendons preoperative size predictability before acl reconstruction surgery.

Eligibility criteria: Inclusion Criteria:

* Ages between 18-45 years
* Diagnosed Acl rupture preoperavitely with mri imaging
* Diagnosed Acl rupture and having symptoms related to acl rupture
* Eligible for harvesting same side semitendinosus or peroneous longus tendon

Exclusion Criteria:

* Previous surgery history on donor side knee or ankle
* Congenital defect on donor extremity
* Multiple Ligament Injury History

Primary outcomes:
measure: Correlation Between Preoperative Anthropometric Variables and Autograft Dimensions
timeFrame: Intraoperatively
Secondary outcomes:
measure: Comparison of Predictability Between Peroneus Longus and Semitendinosus Tendons
timeFrame: Preoperatively at surgery day
measure: Predictability of Autograft Dimensions Based on Preoperative Anthropometric Data
timeFrame: Intraoperatively
Other outcomes:
Locations:
city: Trabzon
country: Turkey
facility: Karadeniz Technical University, Orthopedic and Traumatology Department
Study officials:
References:
citation: Wierer G, Gwinner C, Scheffler S. Peroneus Longus Split Versus Semitendinosus Tendon Autograft Size: A Cross-sectional Study. Am J Sports Med. 2023 Jun;51(7):1743-1751. doi: 10.1177/03635465231165297. Epub 2023 Apr 24.
Clinical trial NCT00155324: Change and Clinical Significance of Plantar Fascia Thickness After ESWT
Official title: Change and Clinical Significance of Plantar Fascia Thickness After Extracorporeal Shock Wave Therapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Plantar Fasciitis
Keywords: plantar fasciitis
ultrasonographic examination
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2005-09-12
Enrollment: 60
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to investigate the effect of extracorporeal shock wave therapy (ESWT) on the thickness of plantar fascia measured by ultrasonographic examination among patients with chronic plantar fascitis. The change of plantar fascia thickness will be correlated with clinical improvement.

Detailed description: The aim of the study is to investigate the effect of extracorporeal shock wave therapy (ESWT) on the thickness of plantar fascia measured by ultrasonographic examination among patients with chronic plantar fascitis. Two different dosage of ESWT will be applied, and the outcome will be followed 3 and 6 months after the treatment. The change of plantar fascia thickness will be correlated with clinical improvement, including the pain improvement, foot function, and quality of life at follow up.

Eligibility criteria: Inclusion Criteria:

* diagnosed as plantar fasciitis for at least 6 months
* refractory to other conservative treatments

Exclusion Criteria:

* Acute infection of soft tissue/bone
* Malignancy
* Epiphysiolysis in the focus
* Blood coagulation disorders
* Pregnancy
* Patients with pacemaker
* Foot deformity
* Autoimmune disorders-related arthropahy
* Sciatica
* Previous treatment with ESWT

Primary outcomes:
measure: Thickness of plantar fascia by ultrasonographic examination at 3 & 6 months
Secondary outcomes:
measure: Pain (visual analogue scale) at 3 & 6 months
measure: Foot function index at 3 & 6 months
measure: Short Form-36 at 3 & 6 months
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: H W Liang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00281424: Increasing Walking Following Cardiac Rehabilitation
Official title: Increasing Walking Following Completion of Cardiac Rehabilitation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Cardiac Diseases
Walking
Keywords: exercise adherence
cardiac patients
walking
Lead sponsor: University of Alberta
Sponsor class: OTHER
First posted: 2006-01-24
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the project was to test the widely endorsed assumption that pedometers produce or encourage more physical activity participation in the form of walking. The investigators hypothesized that pedometers would not increase the amount of walking cardiac patients participated in after their cardiac rehabilitation program compared to patients without pedometers.

Detailed description: As evidenced by the media attention given to pedometers and recent physical activity promotional efforts focused on pedometers, people seem to think that owning a pedometer will influence activity levels.

However, an examination of a few social cognitive theories produces no theoretical rationale that would support any sustained positive influence of pedometers in the absence of some other conditional factor, such as a behavioural goal or a social support system. We believe that once people determine how many steps their usual routes and daily activity typically amounts to, that the pedometer will no longer be used. We based our contentions on two theories: self efficacy theory (Bandura, 1986;1997) and self-determination theory (Deci \& Ryan, 2000).

Eligibility criteria: Inclusion Criteria:

* All patients referred to the Northern Alberta Cardiac Rehabilitation Program
* Patients who are willing to participate
* Are able to read English
* Patients who are able to walk at 2.0 mph based on their exercise stress test results

Exclusion Criteria:

* patients unable to walk or walking contra-indicated
* unwilling
* do not read English

Primary outcomes:
measure: Physical activity behaviour
timeFrame: months
Secondary outcomes:
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: Glenrose Rehabilitation Hospital
state: Alberta
Study officials:
affiliation: University of Alberta
name: Wendy M Rodgers, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05100524: Motivational Interview for Daily Living Activities in Elderly People Undergoing Total Knee Replacement
Official title: The Effect of Motivational Interview for Daily Living Activities on Physical Adjustment and Quality of Life in Elderly People Who Have Had Total Knee Replacement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Motivation
Behavior, Health
Nursing Caries
Nurse's Role
Keywords: motıvatıonal ıntervıew
total knee prosthesıs
old age
quality of life
physical compatibility
Lead sponsor: Maltepe University
Sponsor class: OTHER
Collaborators: name: Saglik Bilimleri Universitesi
First posted: 2021-10-29
Enrollment: 70
Sex: ALL
Minimum age (years): 65
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Parallel Assignment
Primary purpose: SUPPORTIVE_CARE

Brief summary: Purpose: In this study, it was aimed to examine the effect of motivational interview on daily living activities on physical adaptation and quality of life in elderly people who underwent total knee replacement.it was aimed to examine the effect of motivational interview on daily living activities on physical adaptation and quality of life in elderly people who underwent total knee replacement.

Design: The research was planned as a pretest, posttest, randomized controlled study in order to determine the effect of the motivational interviews on the life quality and physical activity of old patients.

H1: After total knee replacement, the target for daily living activities is higher than the patients who applied the hand and those who did not.

H2: Patients with targeted daily living activities with total knee replacement begin to get used to it and begin earlier than those who do not.


Eligibility criteria: Inclusion Criteria:

* Those aged 65 and over,
* Having total knee replacement,
* The non-spiritual system (the peasant of the sick),
* A person who can read and write can cope at a level that prevents conversation,
* First time system add-on,
* They are viewed as agreeing to participate in the research.

Exclusion Criteria:

* Neurological (such as dementia) and psychiatric (such as schizophrenia) medical diagnoses that affect cognitive status
* Patients who did not participate in the motivational interviews and who wanted to leave the study were determined.

Primary outcomes:
measure: The SF-36 Quality of Life Scale
timeFrame: For 3 months
measure: Functional Evaluation Form
timeFrame: For3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Ataşehi̇r
country: Turkey
facility: Gizem Kubat Bakir
state: İ̇stanbul
Study officials:
affiliation: GİZEM KUBAT BAKIR
name: GİZEM KUBAT BAKIR
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05680324: Impact of Monsplasty in Women Undergoing Abdominoplasty
Official title: the Aesthetic and Functional Impact of Monsplasty in Women Undergoing Abdominoplasty
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Liposuction
Mons Pubis Lift
Keywords: monsplasty
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-01-11
Enrollment: 24
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Evaluate The aesthetic and function satisfaction outcomes of different monsplasty surgery with or after abdominoplasty

Detailed description: The high incidence of female obesity has resulted in common complaints of a large mons pubis and labia majora (outer labial lips) related to unsightly fat deposits. The mons and labia majora enlarge, protrude, descend, and hang. Even with dramatic weight loss, these areas remain descended and bulky, with excess fat and skin. The affected majora can cause difficulty with sexual intercourse and maintenance of hygiene, and result in discomfort when wearing pants and swimsuits. These unnatural .fat deposits can also severely affect self-esteem

The surgical treatment of the enlarged mons pubis and labia majora has been poorly understood and therefore often neglected. Traditionally, the mons has been treated by fat reduction, whether by liposuction or open excision, along with a pubic skin lift. However, skin elevation is usually unsatisfactory, because the mons will descend again upon standing. Many of these unsuccessful lifts present after a simultaneous abdominoplasty.

In many ways, the treatment of the mons pubis correlates with the treatment of the hidden penis in the obese or formerly obese male.1-3 Excess suprapubic skin and mons fat removal-along with tacking of the fibrofatty tissue of the pubic skin flap to the rectus fascia-are mandatory to achieve a lasting, successful mons pubis lift.4 Labia majora reduction. Depends on the surgically appropriate removal of fat and/or skin

Eligibility criteria: Inclusion Criteria:

* Any adult married woman from 20 to 45 years old candidate for abdominoplasty with stable weight in last 6 months

Exclusion Criteria:

* patients less than 20 years old and more than 45 years old
* patients with medical conditions affecting wound healing
* patients with skin infection in lower abdomen and pubic area

Primary outcomes:
measure: Determine better result
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut university
Study officials:
References:
Clinical trial NCT04437524: Comparison of the Effects of Balance-proprioception and Aerobic Exercises on Functional Status and Strength Parameters in Patients With Fibromyalgia.
Official title: Comparison of the Effects of Balance-proprioception and Aerobic Exercises on Functional Status, Pain and Strength Parameters in Patients With Fibromyalgia Syndrome (FMS).
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Fibromyalgia Syndrome
Keywords: Fibromyalgia, aerobic exercise, balance, proprioception, pain, strength
Lead sponsor: Istanbul University
Sponsor class: OTHER
First posted: 2020-06-18
Enrollment: 51
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study, it was aimed to examine the effects of aerobic exercise and balance-proprioception exercises on pain, functionality and strength parameters of fibromyalgia patients and to compare the two exercise types.

Detailed description: In the study planned to evaluate the effect of aerobic and balance-proprioception exercises on the symptoms of the disease and the superiority of the two exercise models in patients with fibromyalgia syndrom (FMS), 62 women who meet the inclusion criteria will be randomly divided into two groups. Aerobic exercise group (n = 26) and balance-proprioception exercise group (n = 26) will be applied for 3 weeks a week, 6 days a week under the supervision of a physiotherapist in the exercise laboratory of the Istanbul Medical Faculty Sports Medicine Department. Pain (VAS), functional status (FİQ) and knee extension muscle strength (Cybex isokinetic dynamometer) will be evaluated before and after the program. Cognitive status will be evaluated with standardized Mini Mental Test only before the program.

Eligibility criteria: Inclusion Criteria:

* Being between the ages of 18 and 60,
* Symptoms lasting longer than 3 months,
* According to the 2013 ACR criteria, the Pain Settlement Score (PLI) is ≥17,
* According to the 2013 ACR criteria, the Symptomatic Impact Scoring (SIQR) is ≥21,
* Acceptance of treatment that will continue 3 days a week for 6 weeks,
* The possibility of any change in medical treatment due to FMS during the study is not foreseen.

Exclusion Criteria:

* Known central or peripheral nervous system disease, progressive neurological damage,
* Any serious cardiovascular pathology,
* Sense, loss of sense of position, unhealed fracture or a surgical wound,
* Presence of uncontrolled hypertension,
* Failure to understand or perform simple commands.

Primary outcomes:
measure: Fibromyalgia Impact Questionnaire (FIQ)
timeFrame: 6 weeks
measure: Pain (Visual Analogue Scale)
timeFrame: 6 weeks
measure: Muscle Strength Evaluation
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: İstanbul Faculty of Medicine, Department of Sports Medicine
Study officials:
affiliation: İstanbul Univesity, İstanbul Faculty of Medicine
name: Gökhan Metin, Professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT00651196: Bone Health in Type 1 Diabetes
Official title: Pilot Study - Type 1 Diabetes and Bone Health
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Type 1 Diabetes
Osteoporosis
Keywords: Type 1 diabetes
bone
Lead sponsor: Creighton University
Sponsor class: OTHER
First posted: 2008-04-02
Enrollment: 60
Sex: ALL
Minimum age (years): 19
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: males or females who are greater than 19 years of age and less than age 50 who have been diagnosed with type 1 diabetes for over 3 years.

Brief summary: An increased skeletal fracture risk in diabetes has only recently been recognized. This human study is designed to elucidate the effect of Type 1 diabetes on bone remodeling and on structure.

Detailed description: An increased skeletal fracture risk in diabetes has only recently been recognized. Human studies of patients with diabetes using bone mineral density and bone markers have noted low bone mass and mixed results on remodeling activity. Mouse models of diabetes have suggested that low bone turnover is the underlying problem. Low bone turnover could lead to an accumulation of microdamage that is not repaired causing compromised bone strength. Low bone turnover has not yet been confirmed in humans. This human study is designed to elucidate the effect of Type 1 diabetes on 1) bone remodeling, including histomorphometric and biochemical measures of bone formation and resorption, and 2) on structure, including micro architectural arrangement of trabeculae and bone mineral density.

Eligibility criteria: Inclusion Criteria:

* Age \> 19 yrs or \< 50 yrs.
* The diabetic subjects must have a diagnosis of Type 1 diabetes clinically defined as diabetes onset before age 50, acute presentation or diabetic ketoacidosis, with normal BMI. If history is equivocal, GAD antibodies \> 1.45 U/mL will be used to define diagnosis.
* Diabetic subjects must be on insulin treatment.
* All subjects must have BMI between 18-30

Exclusion Criteria:

* On any medications that are known to interfere with bone metabolism including loop diuretics, steroids, anticonvulsants, bisphosphonates, metformin, glitazones
* Have normal or only mildly impaired kidney function defined as a calculated GFR greater than 60 mL/min/1.73m2
* History of cancer other than skin cancer
* Unstable angina, myocardial infarction, uncontrolled hypertension, malabsorption, active rheumatoid or collagen disease.

Primary outcomes:
measure: histomorphometry measurements
timeFrame: at 2nd visit
Secondary outcomes:
measure: peripheral QCT measurements
timeFrame: at 1st visit
measure: micro CT measurements
timeFrame: at 2nd visit
measure: nanoindentation measurements
timeFrame: at 2nd visit
measure: Bone mineral density
timeFrame: at 1st visit
Other outcomes:
Locations:
city: Omaha
country: United States
facility: Creighton University
state: Nebraska
Study officials:
affiliation: Creighton University
name: Laura A Armas, MD
role: PRINCIPAL_INVESTIGATOR
References: