Clinical trial NCT06449716: Tailored Versus Traditional Resistance Exercise
Official title: A Tailored Intervention to Prevent Age-Related Declines in Muscle Power and Functional Ability
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Exercise Training
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2024-06-10
Enrollment: 72
Sex: ALL
Minimum age (years): 65
Maximum age (years): 80
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Preserving functional ability is crucial for healthy aging. Unfortunately, age-related decreases in muscle power often lead to declines in functional ability. As power is the product of force and velocity, decreases in power can originate from changes in muscle force, contraction velocity, or both, varying between individuals. The primary method to prevent functional disability is power-based resistance training. Although training interventions are effective for most older adults, they do not induce substantial improvements in a subset of the population. These inconsistent outcomes may arise from neglecting the observed differences in the force-velocity (F-v) profiles between individuals. Therefore, this study provides a novel approach to resistance exercise, in which exercise dose is tailored according to the individual's F-v profile. The effectiveness of the tailored method will be assessed in a randomized control trial, comparing the effects of an individualized and a non-individualized 12-week training intervention on muscle power parameters and functional ability.


Eligibility criteria: Inclusion Criteria:

* Community-dwelling adults
* 65-80 years old

Exclusion Criteria:

* Systematic engagement in resistance exercise during the past year
* Unstable cardiovascular disease, neuromuscular disease, acute infection or fever
* Recent surgery
* Lower-extremity injuries
* Low levels of functional ability (i.e., SPPB score ≤ 9)
* Cognitive malfunctioning (i.e., Mini-Mental State Examination \< 24)

Primary outcomes:
measure: Maximal force (F0)
timeFrame: Change from baseline in maximal force at 12 weeks
measure: Maximal velocity (V0)
timeFrame: Change from baseline in maximal velocity at 12 weeks
measure: Force-velocity slope
timeFrame: Change from baseline in F-v slope at 12 weeks
measure: Maximal power (P0)
timeFrame: Change from baseline in maximal power at 12 weeks
measure: Force at maximal power
timeFrame: Change from baseline in force at maximal power at 12 weeks
measure: Velocity at maximal power
timeFrame: Change from baseline in velocity at maximal power at 12 weeks
Secondary outcomes:
measure: Exercise adherence
timeFrame: Total adherence over 12-week period
measure: Short Physical Performance Battery (SPPB) score
timeFrame: Change from baseline in SPPB test score at 12 weeks
measure: Gait speed
timeFrame: Change from baseline in gait speed at 12 weeks
measure: Countermovement jump height
timeFrame: Change from baseline in countermovement jump height at 12 weeks
measure: Timed up and go
timeFrame: Change from baseline in timed up and go time at 12 weeks
measure: 5-repetition sit-to-stand time
timeFrame: Change from baseline in sit-to-stand performance at 12 weeks
measure: 5-repetition sit-to-stand power
timeFrame: Change from baseline in sit-to-stand performance at 12 weeks
measure: Stair ascent time
timeFrame: Change from baseline in stair climbing performance at 12 weeks
measure: Stair ascent power
timeFrame: Change from baseline in stair climbing performance at 12 weeks
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: KU Leuven - Department of Movement Sciences
state: Vlaams-Brabant
Study officials:
References: