Clinical trial NCT02830269: Third Ventricle Echographic Study for Neuro-intensive Care Unit Patients
Official title: Third Ventricle Echographic Study for Neuro-intensive Care Unit Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neuro-intensive Care Unit Patients
Brain Injuries
Keywords: Neuro-ICU
Third ventricle
Computer Tomography
Transcranial Doppler ultrasonography
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2016-07-12
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients admitted to the neurointensive care

Brief summary: Transcranial Doppler ultrasonography is usually used in the evaluation and management of patients with brain injury. This noninvasive method measures local blood flow velocity and direction in the proximal portions of large intracranial arteries. The operator requires a short training and experience to perform. The third ventricle diameter measurement by transcranial duplex flow sonography was performed in healthy volunteers . This studies show similar results in those obtained with the MRI or Computer Tomography (CT). Currently the third ventricle diameter measurements by transcranial Doppler ultrasonography was not validated for neuro-intensive care unit patients. The investigators propose to used recent ultrasound system to validate the third ventricle diameter measurements in comparison with the standard method (CT).

Detailed description: Transcranial Doppler ultrasonography is usually used in the evaluation and management of patients with brain injury. This noninvasive method measures local blood flow velocity and direction in the proximal portions of large intracranial arteries. The operator requires a short training and experience to perform. The third ventricle diameter measurement by transcranial duplex flow sonography was performed in healthy volunteers . This studies show similar results in those obtained with the MRI or Computer Tomography (CT). Currently the third ventricle diameter measurements by transcranial Doppler

Eligibility criteria: Inclusion Criteria:

* Adult, \> or equal to 18-yr
* Admission to neuro-intensive care unit with brain injury
* Evaluation by Computer Tomography
* Indication for Transcranial Doppler ultrasonography

Exclusion Criteria:

* Opposition to participate by the patient or a next of kin

Primary outcomes:
measure: Third ventricle diameter (average +/- standard deviation)
timeFrame: Through study completion (30 months)
Secondary outcomes:
measure: Residents' learning curve
timeFrame: 24 months
Other outcomes:
Locations:
city: Montpellier
country: France
facility: UHMontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: GERALD CHANQUES, MD, Ph D
role: STUDY_DIRECTOR
affiliation: University Hospital, Montpellier
name: Pierre-François PERRIGAULT, MD
role: STUDY_CHAIR
affiliation: University Hospital, Montpellier
name: Paul BORY, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Widehem R, Bory P, Greco F, Pavillard F, Chalard K, Mas A, Djanikian F, Carr J, Molinari N, Jaber S, Perrigault PF, Chanques G. Transcranial sonographic assessment of the third ventricle in neuro-ICU patients to detect hydrocephalus: a diagnostic reliability pilot study. Ann Intensive Care. 2021 May 4;11(1):69. doi: 10.1186/s13613-021-00857-x.