louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02200835: Gender-related Differences in Chinese Patients With AAD
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aneurysm Dissecting
Keywords: aortic dissection
Chinese patients
gender differences
Lead sponsor: General Hospital of Beijing PLA Military Region
Sponsor class: OTHER
First posted: 2014-07-25
Enrollment: 2015
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Chinese pupolation and foreign citizen of Chinese origin from 15 major hospitals in China

Brief summary: Few data exist on gender-related differences in clinical features, management, and outcomes of acute aortic dissection (AAD) in China. Accordingly, we enrolled 2015 patients with AAD from 15 hospitals in China to access differences in clinical features, management and outcomes between men and women. in this study, our results provided new insights into gender-related differences in clinical features, management and outcomes in the Chinese patients with AAD. Important implications may be helpful to improve diagnostic and therapeutic outcomes.


Eligibility criteria: Inclusion Criteria:

* Patients with acute aortic dissection

Exclusion Criteria:

* Simple dilated aneurysm and penetrating atherosclerotic ulcer

Primary outcomes:
measure: all patients with acute aortic dissection
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01632735: Mobile Continuing Care Approach for Youth
Official title: Mobile Continuing Care Approach for Youth
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Addiction
Keywords: Continuing Care
Youth Substance Abuse
Recovery Support
Mobile Texting
Lead sponsor: Azusa Pacific University
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
name: University of California, Los Angeles
First posted: 2012-07-03
Enrollment: 80
Sex: ALL
Minimum age (years): 12
Maximum age (years): 24
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The primary purpose of this study is to test the effectiveness of a pilot mobile based continuing care program (monitoring/feedback texting) relative to standard continuing care as usual in reducing relapse and improving psychosocial functioning outcomes in a youth population (under 24) with substance abuse problems.

Detailed description: This study will include approximately 80 participants randomized to either 12 weeks of mobile continuing care (intervention) or standard continuing care as usual (control). Participants will be recruited from the treatment programs in Los Angeles County, including Matrix Institute on Addictions, Tarzana Treatment, Twin Town, Phoenix House, and Cri-Help. During the 12-week active program, participants will be monitored monthly via telephone data collection. Both groups will be followed for 10-months using repeated assessments (self-report and urine specimens) at baseline (month 0) and at follow-up points (months 3, 6, and 9).

Eligibility criteria: Inclusion Criteria:

1. Youth between 12 and 24 years old
2. Youth in treatment for substance abuse
3. Youth who complete treatment (minimum 12 weeks)
4. Youth who have the cognitive capacity to understand study procedures and agree to participate

Exclusion Criteria:

1. Presence of an adverse (life threatening) medical condition that could interfere with study participation.
2. Presence of psychiatric co-occurring illness or symptoms warranting safety concerns or continued treatment, including acute suicide risk; and
3. Current homelessness (unless residing in recovery home for which contact information can be provided).

Primary outcomes:
measure: Primary Substance Use (Defined as Substance Received Treatment for)
timeFrame: Baseline, discahrge, 3 month follow-up, 6 month follow-up, 9 month follow-up
Secondary outcomes:
measure: Participation in Recovery Behaviors Over Time
timeFrame: baseline, discharge, 3-, 6- and 9-month follow-ups
measure: Recovery Confidence (Self-efficacy) Over Time
timeFrame: baseline, discharge, 3-, 6-, and 9-month follow-ups
measure: Social Support Utilization
timeFrame: Baseline, discahrge, 3 month follow-up, 6 month follow-up, 9 month follow-up
Other outcomes:
Locations:
city: Azusa
country: United States
facility: Azusa Pacific University Psychology Department
state: California
Study officials:
affiliation: Azusa Pacific University
name: Rachel Gonzales-Castaneda, MPH, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01050335: Collaborative Surgical Proficiency Initiative
Official title: Collaborative Surgical Proficiency Initiative
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Surgical Proficiency
Lead sponsor: Phoenix Integrated Surgical Residency
Sponsor class: OTHER
First posted: 2010-01-15
Enrollment: 90
Sex: ALL
Minimum age (years): 23
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Surgical residents and attendings from Banner Good Samaritan Medical Center

Brief summary: The purpose of this study is to provide a quantitative base line comparison to determine a surgeon's proficiency based on that surgeon's hand and tool movements while performing simulation tasks.


Eligibility criteria: Inclusion Criteria:

* Surgical residents and attendings from Banner Good Samaritan Medical Center
* Range in age from 23-65 years
* Willing to provide informed consent

Exclusion Criteria:

* N/A

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Simulation and Education Training (SimET) Center, Banner Good Samaritan Medical Center
state: Arizona
Study officials:
affiliation: Simulation and Education Training (SimET) Center, Banner Good Samaritan Medical Center
name: Kanav Kahol, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Phoenix Integrated Surgical Residency
name: John Ferrara, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05198635: Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy
Official title: Association Between Local Cerebral Oxygen Saturation Monitoring and Postoperative Delirium in Carotid Endarterectomy：A Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cerebral Oxygen Saturation
Postoperative Delirium
Carotid Endarterectomy
Lead sponsor: Beijing Tiantan Hospital
Sponsor class: OTHER
First posted: 2022-01-20
Enrollment: 140
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Scheduled carotid endarterectomy

Brief summary: Postoperative delirium (POD) is a common perioperative complication, which can lead to adverse outcomes. Patients undergoing carotid endarterectomy (CEA) were elderly, complicated with vascular risk factors, cognitive dysfunction, some also had a history of stroke, and the circulation fluctuated greatly during the operation, often resulting in hypoperfusion of cerebral tissue and hypoxia. Therefore, they're the high-risk group of POD. Near-infrared Spectroscopy (NIRS) can continuously and noninvasively monitor local cerebral oxygen saturation (SctO2) to identify the mismatch of oxygen supply and demand in brain tissue. However, for CEA patients, the association between intraoperative SctO2 changes and POD remains unclear. This study intends to explore the association between them and determine the SctO2 threshold for predicting POD. We will monitor SctO2 intraoperatively, follow up and collect data postoperatively.


Eligibility criteria: Inclusion Criteria:

Scheduled carotid endarterectomy; Signed informed consent.

Exclusion Criteria:

Severe cognitive impairment(Mini-Mental State Examination, MMSE\<18); History of psychotropic drugs; Previous intracranial surgery history; Poor hearing or vision; Language barriers

Primary outcomes:
measure: Postoperative delirium
timeFrame: With postoperative 5 day
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Tian Tan Hospital, Capital Medical University
state: Beijing
Study officials:
affiliation: Beijing Tian Tan Hospital
name: Yuming MD Peng, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05852535: Spontaneous Evisceration of Infantile Umbilical Hernia
Official title: Spontaneous Evisceration of Infantile Umbilical Hernia
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pediatric Disorder
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-05-10
Enrollment: 1
Sex: MALE
Minimum age (years): 1
Maximum age (years): 3
Standard ages: CHILD
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: pediatric age group

Brief summary: Infantile umbilical hernia is common in children. It has a regressive course in most cases. Conservative management is the standard in most cases before the age of 3 years unless there are complications such as incarceration, rupture with evisceration which are extremely rare and warrants emergency surgery.

We present a rare case of a 6-month-old child with sudden spontaneous evisceration of infantile umbilical hernia.

Detailed description: Infantile umbilical hernia is common in children. It has a regressive course in most cases. Conservative management is the standard in most cases before the age of 3 years unless there are complications such as incarceration, rupture with evisceration which are extremely rare and warrants emergency surgery.

We present a rare case of a 6-month-old child with sudden spontaneous evisceration of infantile umbilical hernia.

Eligibility criteria: Inclusion Criteria:

* Pediatric group

Exclusion Criteria:

* Adult group

Primary outcomes:
measure: hospital stay
timeFrame: From April 1, 2023 to April 1, 2024
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Ahmed Ali
Study officials:
References:
Clinical trial NCT05118035: Applying an Artificial Intelligence-Enabled Electrocardiographic System for Reducing Mortality
Official title: Applying an Artificial Intelligence-Enabled Electrocardiographic System for Reducing Mortality: a Pragmatic Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiovascular Diseases
Intensity Care
Morality
Lead sponsor: National Defense Medical Center, Taiwan
Sponsor class: OTHER
First posted: 2021-11-11
Enrollment: 15965
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: intervention group:8001 control group:7964
Primary purpose: SCREENING

Brief summary: This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for early detection of clinical deterioration for reducing mortality.


Eligibility criteria: Inclusion Criteria:

* Patients in emergency department or inpatient department.
* Patients recieved at least 1 ECG examination.

Exclusion Criteria:

* The patients recieved ECG at the period of inactive AI-ECG system.

Primary outcomes:
measure: All cause mortality (death)
timeFrame: Within 90 days
Secondary outcomes:
measure: Cardiovascular cause mortality (death)
timeFrame: Within 90 days
measure: Arrhythmia medication
timeFrame: Within 12 hours
measure: Electrolyte examination
timeFrame: Within 3 days
measure: Cadiac examination
timeFrame: Within 3-7 days
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Defense Medical Center
Study officials:
References:
Clinical trial NCT04245735: The Role of Perfusion Index in Children
Official title: The Role of Peripheral Perfusion Index in Evaluating the Success of Peripheral Nerve Block in Children Under Sedation
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Perfusion Index
Lead sponsor: Erzincan University
Sponsor class: OTHER
Collaborators: name: Derince Training and Research Hospital
First posted: 2020-01-29
Enrollment: 60
Sex: ALL
Minimum age (years): 2
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 60 patients with ASA 1 between the ages 2-10 who will undergo elective upper extremity surgery will be included in the study.

Brief summary: The purpose of our study is to test the usability of the perfusion index in evaluating the success of the peripheral nerve block applied under sedation in children.


Eligibility criteria: Inclusion Criteria:

* will undergo elective upper limb surgery,
* 2- 10 years old,
* ASA I

Exclusion Criteria:

* have regional anesthesia contraindications,
* allergic to local anesthetics,
* having an infection at the injection site
* patients who do not accept the procedure

Primary outcomes:
measure: perfusion index
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Abdelnasser A, Abdelhamid B, Elsonbaty A, Hasanin A, Rady A. Predicting successful supraclavicular brachial plexus block using pulse oximeter perfusion index. Br J Anaesth. 2017 Aug 1;119(2):276-280. doi: 10.1093/bja/aex166.
citation: Kus A, Gurkan Y, Gormus SK, Solak M, Toker K. Usefulness of perfusion index to detect the effect of brachial plexus block. J Clin Monit Comput. 2013 Jun;27(3):325-8. doi: 10.1007/s10877-013-9439-4. Epub 2013 Feb 10.
citation: Galvin EM, Niehof S, Verbrugge SJ, Maissan I, Jahn A, Klein J, van Bommel J. Peripheral flow index is a reliable and early indicator of regional block success. Anesth Analg. 2006 Jul;103(1):239-43, table of contents. doi: 10.1213/01.ane.0000220947.02689.9f.
citation: Sebastiani A, Philippi L, Boehme S, Closhen D, Schmidtmann I, Scherhag A, Markstaller K, Engelhard K, Pestel G. Perfusion index and plethysmographic variability index in patients with interscalene nerve catheters. Can J Anaesth. 2012 Dec;59(12):1095-101. doi: 10.1007/s12630-012-9796-3. Epub 2012 Oct 2.
citation: Xu Z, Zhang J, Shen H, Zheng J. Assessment of pulse oximeter perfusion index in pediatric caudal block under basal ketamine anesthesia. ScientificWorldJournal. 2013 Sep 19;2013:183493. doi: 10.1155/2013/183493. eCollection 2013.
Clinical trial NCT03277235: Effect of a Resilience Model-Based Care Plan in Newly Diagnosed Colorectal Cancer Patients
Official title: Effect of a Resilience Model-Based Care Plan in Reducing Fear of Recurrence and GI Symptom Distress and Improving Quality of Life in Newly Diagnosed Colorectal Cancer Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colon Cancer
Keywords: fatigue
colon cancer
quality of life
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2017-09-11
Enrollment: 128
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aims of this three-year study are to explore the protective and risk factors of resilience in colorectal cancer patients, and examine the effect of the resilience model-based care plan in reducing fear of recurrence and GI symptom distress and improving quality of life in newly diagnosed colorectal cancer (CRC) patients.

Detailed description: Develop and evaluate the effect of a resilience model-based total care plan on reducing fear of recurrence and GI symptom distress and improving quality of life (QOL) in this population.

Eligibility criteria: Inclusion Criteria:

* patients with stage I to III colon cancer.

Exclusion Criteria:

* patients with cancer other than colon cancer or have cancer recurrence.

Primary outcomes:
measure: Resilience scale
timeFrame: Change from baseline resilience at 12 months
Secondary outcomes:
measure: Self-report Questionnaire
timeFrame: Change from baseline fear of cancer recurrence at 12 months
measure: Self-report Questionnaire
timeFrame: Change from baseline symptom at 12 months
measure: Fatigue Symptom Inventory
timeFrame: Change from baseline fatigue at 12 months
measure: Center for Epidemiological Studies Depression Scale
timeFrame: Change from baseline depressive symptoms at 12 months
measure: Functional Assessment of Chronic Illness Therapy - Spiritual Well-Being Scale
timeFrame: Change from baseline spiritual well-being at 12 months
Other outcomes:
measure: Self-report Questionnaire
timeFrame: Change from baseline quality of life at 12 months
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University
Study officials:
affiliation: National Taiwan University
name: Shiow-Ching Shun, PHD
role: STUDY_CHAIR
References:
citation: Chou YJ, Lin HY, Cooper BA, Lin BR, Jiang JK, Yang HY, Miaskowski C, Shun SC. A Resilience Model for Patients With Colorectal Cancer: A Structural Equation Modeling Analysis. Cancer Nurs. 2022 Jan-Feb 01;45(1):E83-E90. doi: 10.1097/NCC.0000000000000882.
Clinical trial NCT01267435: Evaluation of Tibial and Femoral Tunnel Position After Arthroscopic Reconstruction of the Anterior Cruciate Ligament
Official title: Study of Evaluation of Tibial and Femoral Tunnel Position After ACL Reconstruction
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Anterior Cruciate Ligament Rupture
Keywords: Arthroscopy, Anterior Cruciate Ligament, Tibial Tunnel.
Lead sponsor: Isfahan University of Medical Sciences
Sponsor class: OTHER
Collaborators: name: Shahid Beheshti University of Medical Sciences
First posted: 2010-12-28
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to evaluate the accuracy of tunnel positions in anterior cruciate ligament reconstruction

Detailed description: The tunnel placement in ACL reconstruction is the most important predictor of clinical outcome and there is a high rate of inaccurate tunnel placements, even when performed by experienced surgeons.Tibial and femoral tunnel positions are one of the major concerns in anterior cruciate ligament reconstruction which have a great impact on the final surgical results

Eligibility criteria: Inclusion Criteria:

* anterior cruciate ligament rupturing

Exclusion Criteria:

* none

Primary outcomes:
measure: number of correct femoral tunnel position
timeFrame: 5 min after operation
Secondary outcomes:
measure: number of correct Tibial tunnel position
timeFrame: 5 min after operation
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Akhtar university hospital
Study officials:
affiliation: research comittee
name: hamidreza shemshaki, MD
role: STUDY_CHAIR
References:
Clinical trial NCT02892786: Detection in Peripheral Blood of Circulating Tumor Cells in Patient With Head and Neck Squamous Cell Carcinoma
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Head and Neck Cancer
Keywords: circulating tumor cell
CellSearch™ method
RT-PCR
Lead sponsor: Institut de Cancérologie de Lorraine
Sponsor class: OTHER
First posted: 2016-09-08
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The dissemination of individual tumor cells is a common phenomenon in solid cancers. Detection of tumor cells in peripheral blood circulating tumor cells (CTC) in nonmetastatic situation is of high prognostic significance.

The objective of our study was to detect circulating tumor cells in two different method in patient with head and neck squamous cell carcinoma .


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years
* Patient with head and neck squamous cell cancer stage III or IV histologically proven
* Patient naive to any prior therapy
* Patient with operate cancer and resectable tumor
* Hemoglobin ≥ 10g / dL
* Performance status ≤ 2
* Ability to provide written informed consent
* Patient's legal capacity to consent to study participation

Exclusion Criteria:

* Other previous histology tumors
* Medical conditions or acute or chronic severe psychiatric disorders
* Deprived of liberty or under supervision

Primary outcomes:
measure: Circulating tumor cells in peripheral blood during head and neck surgery
timeFrame: 7 days
Secondary outcomes:
measure: Comparison between RT-PCR and CellSearch™ method
timeFrame: 1 day
measure: Prognostic marker of relapse
timeFrame: 2 years
Other outcomes:
Locations:
city: Vandoeuvre-les-Nancy
country: France
facility: Institut de Cancérologie de Lorraine
Study officials:
affiliation: Institut de Cancérologie de Lorraine
name: MASTRONICOLA Romina, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT07025486: Effectiveness of HabitWorks and Symptom Tracking for Anxiety and Depression
Official title: Effectiveness of HabitWorks and Symptom Tracking for Anxiety and Depression
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anxiety
Depression, Anxiety
Keywords: interpretation bias
digital mental health
Lead sponsor: Mclean Hospital
Sponsor class: OTHER
First posted: 2025-06-17
Enrollment: 340
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Our objective is to conduct a randomized controlled trial (RCT) that compares two digital interventions - Symptom Tracking and the HabitWorks app - in a sample of adults endorsing symptoms of anxiety or depression. We hope to obtain pilot data to support a fully powered RCT to test moderators:

1. Target engagement (improvement in interpretation bias)
2. Feasibility and acceptability of Symptom Tracking and HabitWorks and procedures for a general community sample
3. Symptom and functioning measures

Detailed description: HabitWorks is a personalized, transdiagnostic, smartphone-delivered interpretation bias intervention. Our pilot studies of HabitWorks revealed good acceptability, feasibility, and target engagement in a variety of populations (Beard, Ramadurai, et al., 2021; Beard, Beckham, et al., 2021). Our next step is to test effectiveness for anxiety and depression symptoms in a larger, community sample. Results will provide pilot data to support an R01 effectiveness trial. We will randomize adults with anxiety or depression to HabitWorks or a credible control arm and examine effects on interpretation bias, symptoms, and functioning.

Eligibility criteria: Inclusion Criteria:

1. Age ≥ 18 at the time of consent (19 in Nebraska, 21 in Puerto Rico based on age of consent)
2. Current US resident
3. Total score ≥ 3 on the Patient Health Questionnaire-2 (Kroenke et al., 2003) or Generalized Anxiety Disorder-2 (Spitzer et al., 2006), indicating at least mild depression and/or anxiety symptoms
4. 24-hour access to an iPhone smartphone
5. ability to understand English

Exclusion criteria:

1. No current psychiatric symptoms that would prevent informed consent, understanding of research procedures, or ability to complete the study (e.g., active symptoms of psychosis, mania)
2. No medical symptoms that would prevent informed consent, understanding of research procedures, or ability to complete the study (e.g., physical disability)

Primary outcomes:
measure: GAD-7
timeFrame: From enrollment to the end of followup period at 8 weeks
Secondary outcomes:
measure: Clinical Global Improvement Scale
timeFrame: post-treatment (4 weeks after enrollment)
Other outcomes:
Locations:
city: BElmont
country: United States
facility: McLean Hospital
state: Massachusetts
Study officials:
References: