Clinical trial NCT02829463: MRI of Infrapatellar Fat Pad in Osteoarthritis
Official title: Magnetic Resonance Imaging of Infrapatellar Fat Pad in Osteoarthritis and Controls
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoarthritis
Lead sponsor: The Third Xiangya Hospital of Central South University
Sponsor class: OTHER
First posted: 2016-07-12
Enrollment: 121
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects who come to see doctors requiring knee MRI test.

Brief summary: In this study, the investigators use the clinical documentation and imaging data of MRI to do research. Clinical subjects were divided into two groups: osteoarthritis patients and healthy controls without osteoarthritis. Differences of MRI data were studied between two groups.

Detailed description: In this study, the investigators applied high precision MRI technique (with as less as a slice thickness of 0.35 mm and without inter-slice gap), and calculated not only the IPFP maximal sagittal area and IPFP volume, but also the quantitated signal, and compared the differences between healthy controls and osteoarthritis patients. This is an observational cross-sectional study without specific interventions to the subjects. MRI is a regular examination in our hospital. And all subjects are included for the reasons of osteoarthritis (need MRI) and healthy controls (pain but not osteoarthritis, also need MRI). The investigator does not assign specific interventions to the subjects of the study.

Eligibility criteria: Inclusion Criteria:

* Patients with clinical knee osteoarthritis;
* The healthy controls who require MRI test.

Exclusion Criteria:

* Contraindications to magnetic resonance imaging;
* Rheumatoid arthritis patients;
* Gout;
* Hemophilic arthritis;
* Subjects who take non-steroidal anti-inflammatory drugs (NSAIDs);
* Subjects who take lipid-lowering agents;
* Subjects who have the history of knee trauma;
* Subjects who have the history of knee operation;
* Subjects who have the disease of musculoskeletal tumor near knee;
* Subjects who have joint loose bodies.

Primary outcomes:
measure: Infrapatellar Fat Pad Volume in MRI
timeFrame: collect the data within 24 hours after the subjects did the MRI
Secondary outcomes:
Other outcomes:
Locations:
city: Changsha
country: China
facility: Jinshen He
state: Hunan
Study officials:
affiliation: Department of Orthopaedic Surgery, Third Xiangya Hospital of Central South University
name: Jinshen He, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pan F, Han W, Wang X, Liu Z, Jin X, Antony B, Cicuttini F, Jones G, Ding C. A longitudinal study of the association between infrapatellar fat pad maximal area and changes in knee symptoms and structure in older adults. Ann Rheum Dis. 2015 Oct;74(10):1818-24. doi: 10.1136/annrheumdis-2013-205108. Epub 2014 May 15.
citation: Han W, Aitken D, Zhu Z, Halliday A, Wang X, Antony B, Cicuttini F, Jones G, Ding C. Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study. Ann Rheum Dis. 2016 Oct;75(10):1783-8. doi: 10.1136/annrheumdis-2015-208360. Epub 2015 Nov 26.