Clinical trial NCT01688622: Glypican4 and CTRP5 in Metabolic Syndrome and the Effect of Exercise on These Adipokines
Official title: Effects of Exercise on Glypican4,CTRP3,5 and RBP4 Levels and Circulating Levels of These Adipokines in the Subjects With or Without Metabolic Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Metabolic Syndrome
Obesity
Lead sponsor: Korea University
Sponsor class: OTHER
First posted: 2012-09-20
Enrollment: 90
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP

Brief summary: Glypican4, CTRP3, CTRP5 are emerging novel adipokines mediating obesity and inflammation related disorders. RBP4 and adiponectin are well known important adipokines. Therefore, we examine the circulating levels of theses adipokines in the subjects with or without metabolic syndrome. Furthermore, we tried to clarify the effect of exercise on the circulating these adipokines.


Eligibility criteria: Inclusion Criteria:

* Women between 30 and 60 years of age who had a body mass index (BMI) more than 25 kg/m2
* The subjects of metabolic syndrome and age, gender matched non metabolic syndrome among the participants of Korean SO Study (KSOS) study, which is an ongoing epidemiologic study supported by the Korea Science and Engineering Foundation

Exclusion Criteria:

* participants had a history of cardiovascular disease
* any type of diabetes
* stage 2 hypertension
* malignant disease, severe renal, or hepatic disease
* Subjects taking medications that might affect body weight or body composition

Primary outcomes:
measure: The changes of circulating glypican4 levels after 3 months exercise
timeFrame: baseline and 12weeks
measure: The changes of circulating CTRP3 levels after 3 months exercise
timeFrame: baseline and 12weeks
measure: The changes of circulating CTRP5 levels after 3 months exercise
timeFrame: baseline and 12weeks
measure: The changes of circulating RBP4 levels after 3 months exercise
timeFrame: baseline and 12weeks
measure: The changes of circulating adiponectin levels after 3 months exercise
timeFrame: baseline and 12weeks
Secondary outcomes:
measure: Circulating glypican4 levels in the subjects with or without metabolic syndrome
timeFrame: baseline
measure: Circulating CTRP3 levels in the subjects with or without metabolic syndrome
timeFrame: baseline
measure: Circulating CTRP5 levels in the subjects with or without metabolic syndrome
timeFrame: baseline
measure: Circulating RBP4 levels in the subjects with or without metabolic syndrome
timeFrame: baseline
measure: Circulating adiponectin levels in the subjects with or without metabolic syndrome
timeFrame: baseline
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
Study officials:
References:
citation: Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, Yoo HJ, Hwang TG, Kim SM, Baik SH, Park KS, Youn BS, Choi KM. Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. Diabetes Care. 2013 Oct;36(10):3321-7. doi: 10.2337/dc13-0178. Epub 2013 Jun 18.
citation: Yoo HJ, Hwang SY, Cho GJ, Hong HC, Choi HY, Hwang TG, Kim SM, Bluher M, Youn BS, Baik SH, Choi KM. Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease. J Clin Endocrinol Metab. 2013 Jul;98(7):2897-901. doi: 10.1210/jc.2012-4297. Epub 2013 Apr 30.