Clinical trial NCT02747225: Measuring the Electrical Properties of Malignant Tissues In Vivo
Official title: Measuring the Electrical Properties of the Malignant Tissues During Cancer Surgeries
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Neoplasms
Keywords: electrical properties
malignant tissues
in vivo
Lead sponsor: Southern Medical University, China
Sponsor class: OTHER
Collaborators: name: Zhujiang Hospital
name: Nanfang Hospital, Southern Medical University
First posted: 2016-04-21
Enrollment: 50
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The patients who are diagnosed with cancer disease and about to have an operation to excise the cancer tissues.

Brief summary: Previously published studies have indicated that there exist difference in electrical properties (EPs), i.e., the conductivity and relative permittivity, between malignant and adjacent normal tissue, which will be useful in the early detection of cancers. However the EP information mainly based on ex vivo measurement of cancer tissues, and few data in vivo were published. The purpose of this study is to in vivo measure the electrical properties of the malignant tissues.

Detailed description: The measurements were safety guaranteed and were conducted during the cancer surgeries. Before the tissue was excised from the patient,the pathologist assisted the operator (already at the operating room) responsible for the measurement.The measurement of malignant and corresponding normal tissues were both performed. The tissues for dielectric properties measurement were classified as normal or malignant by the pathologist based on his own expertise and decision criteria (visual inspection, anatomy) and the per-operative histological examination. The measurements were directly performed on the tissue before excision.The sites of the measured malignant tissues were marked,doubletracked according to the pathological report to make sure the marked sites are malignant. The patient age and tissue temperature at the time of measurement were recorded.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of cancer Disease

Exclusion Criteria:

* None

Primary outcomes:
measure: Conductivity of the Malignant Tissues measured In Vivo
timeFrame: one year
measure: Relative Permittivity of the Malignant Tissues measured In Vivo
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Southern medical university
state: Guangdong
Study officials:
affiliation: School of Biomedical Engineering,Southern Medical University
name: Sherman X Xin, professor
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Bobowski Jake S, Johnson Thomas. Permittivity measurements of biological samples by an open-ended coaxial line. Progress In Electromagnetics Research B 40: 159-183, 2012.
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citation: Smith SR, Foster KR, Wolf GL. Dielectric properties of VX-2 carcinoma versus normal liver tissue. IEEE Trans Biomed Eng. 1986 May;33(5):522-4. doi: 10.1109/TBME.1986.325740. No abstract available.
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