Clinical trial NCT01510496: Transition From Acute to Chronic Pain After Inguinal Hernia, Hysterectomy and Thoracotomy: Analysis of Risk Factors and Association With Genetic Polymorphisms
Official title: Transition From Acute to Chronic Pain After Inguinal Hernia, Hysterectomy and Thoracotomy : Analysis of Risk Factors and Association With Genetic Polymorphisms
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Postoperative Pain
Keywords: Chronic pain
genetic polymorphisms
postoperative pain
Lead sponsor: Fundacion IMIM
Sponsor class: OTHER
First posted: 2012-01-16
Enrollment: 3979
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All spanish patients who undergo scheduled surgery of one of the following types: inguinal herniorrhaphy, hysterectomy, toracothomy.

Brief summary: The treatment of postoperative pain continues to be inadequate in the investigators practice setting.

Inadequate pain treatment not only contributes to postoperative complications in the short term but can also be a factor that favors the development of chronic postoperative pain and diminishes long-term quality of life. Risk factors that can lead to a transition to chronic pain need to be analyzed.


Eligibility criteria: Inclusion Criteria:

* Patients with given inform consent, aged mor than 18 years, who undergo scheduled surgery of one of the following types: inguinal hernia (men), hysterectomy, thoracotomy (men).

Exclusion Criteria:

* Patients aged less than 18 years,
* Patients requiring reoperation because of surgical complications.

Primary outcomes:
measure: Evaluation of chronic postsurgical pain.
timeFrame: After 3 and 12 months of surgery.
Secondary outcomes:
measure: Predictive factors of chronic postsurgical pain.
timeFrame: After 3 and 12 months of surgery.
Other outcomes:
Locations:
city: Badalona
country: Spain
facility: Hospital Municipal de Badalona
state: Barcelona
city: Badalona
country: Spain
facility: Hospital Universitari Germans Trias i Pujol
state: Barcelona
city: Berga
country: Spain
facility: Hospital de San Bernabé
state: Barcelona
city: Granollers
country: Spain
facility: Hospital de Granollers
state: Barcelona
city: L'Hospitalet de Llobregat
country: Spain
facility: Hospital Universitari de Bellvitge
state: Barcelona
city: Manresa
country: Spain
facility: Hospital General de Manresa
state: Barcelona
city: Mataro
country: Spain
facility: Hospital de Mataro
state: Barcelona
city: Sabadell
country: Spain
facility: Hospital Parc Tauli
state: Barcelona
city: Terrassa
country: Spain
facility: Hospital Mutua de Terrassa
state: Barcelona
city: Terrassa
country: Spain
facility: Hospital Universitari Mutua de Terrassa
state: Barcelona
city: Viladecans
country: Spain
facility: Hospital de Viladecans
state: Barcelona
city: Salt
country: Spain
facility: Hospital de Santa Caterina
state: Girona
city: Reus
country: Spain
facility: Hospital Sant Joan de Reus
state: Tarragona
city: Xàtiva
country: Spain
facility: Hospital Lluís Alcanyís de Xàtiva
state: València
city: Barcelona
country: Spain
facility: Hospital del Mar
city: Barcelona
country: Spain
facility: Hospital de l'Esperança
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
city: Barcelona
country: Spain
facility: Hospital Sagrat Cor
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron
city: Barcelona
country: Spain
facility: Hospital Clínic i Provincial de Barcelona
city: Barcelona
country: Spain
facility: Hospital del Sant Boi
city: Girona
country: Spain
facility: Hospital Universitari Doctor Josep Trueta de Girona
city: Lleida
country: Spain
facility: Hospital Santa Maria
city: Valencia
country: Spain
facility: Hospital Clínico de Valencia
city: Valencia
country: Spain
facility: Hospital General Universitario de Valencia
city: Valencia
country: Spain
facility: Hospital Universitari de la Fe
Study officials:
References:
citation: Bande D, Molto L, Pereira JA, Montes A. Chronic pain after groin hernia repair: pain characteristics and impact on quality of life. BMC Surg. 2020 Jul 6;20(1):147. doi: 10.1186/s12893-020-00805-9.
citation: Montes A, Roca G, Sabate S, Lao JI, Navarro A, Cantillo J, Canet J; GENDOLCAT Study Group. Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study. Anesthesiology. 2015 May;122(5):1123-41. doi: 10.1097/ALN.0000000000000611.