Clinical trial NCT03359382: The Rehabilitation Effect of Exercise Training in Cruciate Ligament Reconstruction Patients.
Official title: The Rehabilitation Effect of Exercise Training in Cruciate Ligament Reconstruction Patients.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: ACL Injury
ACL - Anterior Cruciate Ligament Rupture
ACL - Anterior Cruciate Ligament Deficiency
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2017-12-02
Enrollment: 180
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: After anterior cruciate ligament (ACL) injury, the involved quadriceps may demonstrate weakness due to decrease in quadriceps activation. However, elapsed time from the injury may affect muscle strength by restoration of the quadriceps activation. The injury is characterized by joint instability that leads to decreased activity, unsatisfactory knee function, and poor knee-related quality of life in the short term, and it is associated with an increased risk of osteoarthritis on the knee. This study was designed to compare muscle strength, questionnaire and knee function in patients with different exercise training.


Eligibility criteria: Inclusion Criteria:

* cruciate ligament rupture patients

Exclusion Criteria:

* Central nervous or peripheral neuropathy, or those with cardiovascular disease.

Primary outcomes:
measure: Change from preoperative muscle mass
timeFrame: One day after rupture of the cruciate ligament, one day before operative, postoperative 4 months, 7 months, 12 months, 24 months
Secondary outcomes:
measure: Change from preoperative motion analysis
timeFrame: One day after rupture of the cruciate ligament, one day before operative, postoperative 4 months, 7 months, 12 months, 24 months
measure: Change from preoperative muscle strength
timeFrame: One day after rupture of the cruciate ligament, one day before operative, postoperative 4 months, 7 months, 12 months, 24 months
measure: Change from preoperative body composition questionnaire assessment
timeFrame: One day after rupture of the cruciate ligament, one day before operative, postoperative 4 months, 7 months, 12 months, 24 months
measure: Change from preoperative surface electromyography
timeFrame: One day after rupture of the cruciate ligament, one day before operative, postoperative 4 months, 7 months, 12 months, 24 months
measure: Change from preoperative hop test
timeFrame: One day after rupture of the cruciate ligament, one day before operative, postoperative 4 months, 7 months, 12 months, 24 months
measure: Change from preoperative fitness
timeFrame: One day after rupture of the cruciate ligament, one day before operative, postoperative 4 months, 7 months, 12 months, 24 months
measure: Marx activity rating scales questionnaire assessment
timeFrame: one day before operative
measure: Change from preoperative SF-36 questionnaire assessment
timeFrame: One day after rupture of the cruciate ligament, one day before operative, postoperative 4 months, 7 months, 12 months, 24 months
measure: Change from preoperative KOOS questionnaire assessment
timeFrame: One day after rupture of the cruciate ligament, one day before operative, postoperative 4 months, 7 months, 12 months, 24 months
Other outcomes:
Locations:
city: Chiayi City
country: Taiwan
facility: Sports Medicine Center, Chang Gung Memorial Hospital
Study officials:
affiliation: Sports Medicine Center, Chang Gung Memorial Hospital at Chia Yi, Chia Yi, Taiwan
name: Wei-Hsiu Hsu, Dr.
role: STUDY_CHAIR
References: