Clinical trial NCT04464720: AIM to Improve Asthma: Airflow Improvements During Meal-Prep
Official title: AIM to Improve Asthma: Airflow Improvements During Meal-Prep
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Asthma in Children
Pollution; Exposure
Keywords: asthma
pediatric
indoor air pollution
particulate matter
nitrogen dioxide
cooking
ventilation
Lead sponsor: University of California, Berkeley
Sponsor class: OTHER
Collaborators: name: National Institute of Environmental Health Sciences (NIEHS)
First posted: 2020-07-09
Enrollment: 19
Sex: ALL
Minimum age (years): 6
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: This is a trial with a single group, where they receive the intervention following one week of baseline data collection.
Primary purpose: PREVENTION

Brief summary: The investigators propose a pilot trial of kitchen ventilation in the homes of children using a youth engaged research strategy.

Detailed description: In this trial of children ages 6-12, children and their households will receive an intensive home kitchen ventilation intervention after one week of baseline data collection. The intervention includes education regarding improving ventilation in their homes during cooking and replacement of their range hood if it has inadequate flow or an intolerable noise level. During baseline data collection periods the households will be encouraged to continue their regular cooking patterns. The investigators will measure home particulate matter \<2.5 microns (PM2.5) and nitrogen dioxide (NO2) levels for one week at baseline, and a final week after all remaining families receive the cooking ventilation intervention, to assess for changes within each household. The investigators will also examine changes in airways inflammation (as measured by the exhaled fraction of nitric oxide, FeNO), lung function (as measured by spirometry), and reported symptoms after the baseline and intervention period. Members of the research team have successfully conducted youth participatory action research in the low-income, high asthma prevalence community of Richmond, California (CA) as well as extensive youth participatory action research on other environmental health concerns in the low income city of Salinas, CA; using a similar model, the investigators aim to teach research methods to a new group of Richmond youth.

Eligibility criteria: Inclusion Criteria:

* Household has a gas stove
* Household has a range hood that vents to the outdoors
* Household in Richmond or San Pablo

Exclusion Criteria:

* Child has other significant medical illnesses (e.g. prematurity, diabetes)
* living with a smoker who smokes indoors
* family knows they will not have stable housing for the period of the study
* Parent is not fluent in English.

Primary outcomes:
measure: Continuously-Measured Home PM2.5 (Fine Particulate Matter) Levels Prior to Intervention
timeFrame: 1-2 weeks
measure: Continuously-Measured Home PM2.5 (Fine Particulate Matter) Levels Following Intervention
timeFrame: 1-2 weeks
measure: Continuously-Measured Home NO2 (Nitrogen Dioxide) Levels Prior to Intervention
timeFrame: 1-2 weeks
measure: Continuously-Measured Home NO2 (Nitrogen Dioxide) Level Following Intervention
timeFrame: 1-2 weeks
Secondary outcomes:
measure: Spirometry- Forced Vital Capacity (FVC)
timeFrame: measured at the end of the pre-intervention interval
measure: Spirometry- Forced Expiratory Volume in One Second (FEV1)
timeFrame: measured at the end of the pre-intervention interval
measure: Spirometry-Forced Vital Capacity (FVC)
timeFrame: measured at the end of the post-intervention interval
measure: Spirometry- Forced Expiratory Volume in One Second (FEV1)
timeFrame: measured at the end of the post-intervention interval
measure: Fractional Exhaled Nitric Oxide (FeNO)
timeFrame: measured at the end of the pre-intervention interval
measure: Fractional Exhaled Nitric Oxide (FeNO)
timeFrame: measured at the end of the post-intervention interval
measure: Asthma Control
timeFrame: measured at the end of the pre-intervention interval
measure: Asthma Control
timeFrame: measured at the end of the post-intervention interval
Other outcomes:
Locations:
city: Berkeley
country: United States
facility: University of California Berkeley
state: California
Study officials:
affiliation: University of California, Berkeley
name: John R Balmes, MD
role: PRINCIPAL_INVESTIGATOR
References: