Clinical trial NCT06449547: Risk Factors of Anxiety and Depression in Patients With Herpes Zoster Neuralgia
Official title: Risk Factors Analysis of Anxiety and Depression in Patients With Herpes Zoster Neuralgia and Characteristics of Serum Biomarkers and Functional Brain Magnetic Resonance Changes
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Herpes Zoster
Keywords: Anxiety
Depression
Herpes Zoster
Neuralgia
Lead sponsor: Huazhong University of Science and Technology
Sponsor class: OTHER
First posted: 2024-06-10
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: This study will be conducted in patients who are diagnosed as herpes zoster neuralgia

Brief summary: The goal of this observational study is to explore risk factors of anxiety and depression in patients with herpes zoster neuralgia, and the changes of certain serum biomarkers and functional brain magnetic resonance images of these patients.

Detailed description: Patients with herpes zoster neuralgia will be recruited and take Hospital anxiety depression rating scale (Hospital anxiety and 'scale, HADS) evaluation. According to the HADS Scores, patients will be divided into depression group and no depression, or anxiety group and no anxiety group. The clinical data the of two groups will be collected and statistically analyzed to explore the risk factors of anxiety and depression, including the changes of serum biomarkers and functional brain magnetic resonance imaging in patients with herpes zoster neuralgia accompanying anxiety or depression.

Eligibility criteria: Inclusion Criteria:

1. Age more than 18 years old
2. Diagnosed as herpes zoster neuralgia
3. Signing informed consent

Exclusion Criteria:

1. Unable to complete the scale assessment
2. History of mental illness

Primary outcomes:
measure: HADS score
timeFrame: during hospital stay, average of 1 week
Secondary outcomes:
measure: Interleukin (IL）-1β plasma level
timeFrame: during hospital stay, average of 1 week
measure: IL-2 receptor plasma level
timeFrame: during hospital stay, average of 1 week
measure: IL-6 plasma level
timeFrame: during hospital stay, average of 1 week
measure: IL-8 plasma level
timeFrame: during hospital stay, average of 1 week
measure: IL-10 plasma level
timeFrame: during hospital stay, average of 1 week
measure: Interferon(INF)-α plasma level
timeFrame: during hospital stay, average of 1 week
measure: Brain-derived neurotrophic factor (BDNF) plasma level
timeFrame: during hospital stay, average of 1 week
measure: C-reactive protein (CRP) plasma level
timeFrame: during hospital stay, average of 1 week
measure: Area under curve (AUC) of topological metrics of functional brain magnetic resonance imaging
timeFrame: during hospital stay, average of 1 week
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Tongji hospital
state: Hubei
Study officials:
affiliation: Tongji medical college of Huazhong University of Science and technology
name: Yang Shuguang, M.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Du J, Sun G, Ma H, Xiang P, Guo Y, Deng Y, Li S, Li X. Prevalence and Risk Factors of Anxiety and Depression in Patients with Postherpetic Neuralgia: A Retrospective Study. Dermatology. 2021;237(6):891-895. doi: 10.1159/000512190. Epub 2020 Dec 16.