Clinical trial NCT02153463: Activity in Tourette Syndrome
Official title: Enhancing Physical Activity in Children With Tics and Tourette Syndrome: Impact on Tic Severity and Quality of Life
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tourette Syndrome
Persistent Tic Disorder
Keywords: Tourette Syndrome
Persistent Tic Disorder
Physical Activity
Quality of Life
Lead sponsor: Children's Hospital of Eastern Ontario
Sponsor class: OTHER
First posted: 2014-06-03
Enrollment: 14
Sex: ALL
Minimum age (years): 8
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Tics are brief repetitive movements or vocalizations. Gilles de la Tourette's syndrome (TS) is a disorder characterized by recurrent motor and vocal tics. Tourette syndrome and tic disorders affect up to 8% of children. Peak severity of tic disorders occurs between the ages of 8 to 12 years, therefore during childhood and adolescence the most significant impacts are felt. The quality of life of young people with tics is lower than their peers' and tic severity predicts lower quality of life. Studies have also shown negative social perception toward children with tics.

Approximately 50% of patients with Tourette syndrome will have other diagnoses including attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder, anxiety and depression. Studies have shown improvements in ADHD with physical activity. ADHD and tic disorders are thought to involve the same areas of the brain; thus it is possible that tics might also improve with physical activity. However, no studies to date have examined this. The investigators predict that by implementing a motivational physical activity program, in conjunction with physical activity counseling, the investigators will be able to increase levels of physical activity in children with tics and Tourette syndrome, with a positive impact on tic severity.


Eligibility criteria: Inclusion Criteria:

* Participants are between 8-16 years of age.
* Participants are required to have a diagnosis of either Tourette Syndrome or Persistent (Chronic) Motor of Vocal Tic Disorder as per the DSM V.
* Participants must be ambulatory.
* Participants and parents must understand English or French.
* Participants must be able and willing to complete the questionnaires.
* Participants cannot have any changes to their medication for tics, or any other psychotropic medications for 4 weeks prior to and for the entire duration of the study

Exclusion Criteria:

* Participants who cannot ambulate independently.
* Participants who are not permitted to participate in physical education class at school.
* Participants or families who are not willing to be randomly assigned to a study group.

Primary outcomes:
measure: Decrease in Yale Global Tic Severity Scale.
timeFrame: 8 weeks
Secondary outcomes:
measure: Change in The Gilles de la Tourette Syndrome Quality of Life Scale for children and adolescents
timeFrame: 8 weeks
Other outcomes:
measure: Change in PedsQL 4.0 measure
timeFrame: 8 weeks
measure: Change in KidScreen-27
timeFrame: 8 weeks
measure: Chang in The Children's Self-perceived Adequacy and Predilection for Physical Activity Questionnaire
timeFrame: 8 Weeks
measure: Change in step count via pedometer
timeFrame: 8 weeks
Locations:
city: Ottawa
country: Canada
facility: Children's Hospital of Eastern Ontario
state: Ontario
Study officials:
References:
citation: Doja A, Bookwala A, Pohl D, Rossi-Ricci A, Barrowman N, Chan J, Longmuir PE. Relationship Between Physical Activity, Tic Severity and Quality of Life in Children with Tourette Syndrome. J Can Acad Child Adolesc Psychiatry. 2018 Nov;27(4):222-227. Epub 2018 Nov 1.