Clinical trial NCT01275001: Effects of Music Intervention on the Brain Development of Preschool Children
Official title: Effects of Music Intervention on the Brain Development of Preschool Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Child Development
Keywords: brain
brain development
MRI
preschool children
cortical mantle thickness
hippocampal volume
Lead sponsor: Avera McKennan Hospital & University Health Center
Sponsor class: OTHER
First posted: 2011-01-12
Enrollment: 34
Sex: ALL
Minimum age (years): 3
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants in this research project will be involved with a different research project (Avera Family Wellness Program) investigating the effects of a family-based wellness approach to addressing emotional-behavioral needs of preschool-age children and their families. The Avera Family Wellness Program (AFWP) consists of a group of children who receive the family-based intervention and a group of control preschool-age children.

Brief summary: The purpose of this research study is to learn more about the effects a musical intervention has on typical brain development in preschool-aged children.

Detailed description: This study will advance the science on brain research in young children by determining the effects of a musical intervention or training on children's brain development. The study will investigate how regular instruction in the Suzuki-like method of violin affects brain structure and function over the course of approximately five (5) months in preschool-aged children participating in an Early Childhood/Headstart preschool program when compared to a control group of their peers.

Eligibility criteria: Inclusion Criteria:

* Children who are between the ages of 3 and 4.5 years old and are involved in the intervention arm of the Avera Family Wellness Program
* Children who are between the ages of 3 and 4.5 years old and are involved in the control arm of the Avera Family Wellness Program

Exclusion Criteria:

* Unable to provide written consent to participate in the research project
* Unable to complete the MRI scan

Primary outcomes:
measure: Cortical mantle thickness
timeFrame: 5 months
Secondary outcomes:
measure: Hippocampal volume
timeFrame: 5 months
Other outcomes:
Locations:
city: Sioux Falls
country: United States
facility: Avera Research Institute
state: South Dakota
Study officials:
affiliation: Avera McKennan Hospital & University Health Center
name: Timothy Soundy, MD
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Fujioka T, Ross B, Kakigi R, Pantev C, Trainor LJ. One year of musical training affects development of auditory cortical-evoked fields in young children. Brain. 2006 Oct;129(Pt 10):2593-608. doi: 10.1093/brain/awl247. Epub 2006 Sep 7.
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citation: Gogtay N, Giedd JN, Lusk L, Hayashi KM, Greenstein D, Vaituzis AC, Nugent TF 3rd, Herman DH, Clasen LS, Toga AW, Rapoport JL, Thompson PM. Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9. doi: 10.1073/pnas.0402680101. Epub 2004 May 17.