Clinical trial NCT01523639: A Randomized, Placebo-controlled, Double-blind Phase II Study Evaluating if Glucophage Can Avoid Liver Injury Due to Chemotherapy Associated Steatosis
Official title: A Randomized, Placebo-controlled, Double-blind Multicenter Phase II Study to Investigate the Protectivity and Efficacy of Metformin Against Steatosis in Combination With FOLFIRI and Cetuximab in Subjects With First-line Palliative Treated, KRAS-Wild-Type, Metastatic Colorectal Cancer
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Colorectal Cancer
Steatohepatitis
Keywords: liver injury
steatosis
KRAS-Wild-Type
metastatic colorectal cancer
metformin
placebo
chemotherapy
Lead sponsor: Austrian Breast & Colorectal Cancer Study Group
Sponsor class: NETWORK
Collaborators: name: Merck Gesellschaft mbH, Austria
First posted: 2012-02-01
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This multicenter randomized, placebo-controlled phase II study will enroll 132 first-line palliative treated subjects with metastatic KRAS wild type CRC. Subjects with histologically confirmed, KRAS wild-type CRC without previous chemo-therapy for metastatic disease will be screened for this study.

Approximately 10 sites in Austria will participate in the study. Subjects will be randomized in a ratio of 1:1 into two groups.

Detailed description: This multicenter randomized, placebo-controlled phase II study will enroll 132 first-line palliative treated subjects with metastatic KRAS wild type CRC.

Wild-type KRAS is required for study entry. Further target-related parameters, based on current scientific knowledge may be assessed.

Subjects are randomized to Arm A or Arm B Arm A: FOLFIRI in combination with cetuximab and metformin Arm B: FOLFIRI in combination with cetuximab and placebo

A liver biopsy of hepatic metastasis and normal liver tissue is planned before the first cycle and at the end of treatment; with regard to the primary study objective, these subjects are evaluable.

Both efficacy and safety data will be collected. The investigators will assess response to treatment every 8 weeks based on imaging.

Following permanent treatment cessation, subjects will be followed-up for survival.

One interim analysis for futility (54 evaluable patients) and in addition two safety analysis for evaluation of reported adverse events between the two treatment groups will be performed at two different timepoints (20 evaluable patients/54 evaluable patients).

Eligibility criteria: Inclusion Criteria:

* Signed written informed consent
* Male or female \>= 18 years of age
* Diagnosis of histologically confirmed, KRAS "wild-type" adenocarcinoma of the colon or rectum
* Non-resectable metastatic colorectal carcinoma
* Either presence of at least one liver lesion measurable unidimensionally by CT scan or MRI or at least one resectable liver metastasis with non-resectable extrahepatic disease (as assessed within 3 weeks prior to randomisation)
* Subjects scheduled to receive cetuximab and FOLFIRI
* ECOG performance status of 0 - 1 at study entry
* Leukocytes \>= 3.0 x 10\^9/L and neutrophils \>= 1.5 x 10\^9/L, platelets \>= 100 x 10\^9/L, and hemoglobin \>= 8 g/dL
* Bilirubin \<= 1.5 x ULN
* ASAT and ALAT \<= 5 x ULN

Exclusion Criteria:

* Brain metastasis (if suspected, brain scan indicated)
* Previous chemotherapy for the currently existing metastatic disease
* Known or newly diagnosed diabetes
* Patients with ACS within the last three months
* Stage 3 or 4 heart failure defined according to the NYHA criteria
* Uncontrolled angina
* Contraindications to metformin (renal impairment \[eGFR \<45 mL/min/1.73m\^2\], known hypersensitivity to metformin, acute illness \[dehydration, severe infection, shock, acute cardiac failure\]), and suspected tissue hypoxia
* Surgery (excl. diagnostic biopsy, central venous catheter) or irradiation within 2 weeks prior to study entry defined as given written informed consent
* Concurrent chronic systemic immune therapy, chemotherapy, or hormone therapy not indicated in the study protocol
* Administration of any investigational agent(s) within 4 weeks prior to study entry,
* Previous exposure to EGFR-pathway targeting therapy
* Acute or sub-acute intestinal occlusion or history of inflammatory bowel disease
* Known grade 3 or 4 allergic reaction to any of the components of the treatment
* Any concurrent malignancy other than non-melanoma skin cancer, or carcinoma in situ of the cervix. (Subjects with a previous malignancy but without evidence of disease for \>= 5 years will be allowed to enter the trial)
* Pregnancy or lactation
* Inadequate contraception (male or female patients) if of childbearing or procreative potential
* Known drug abuse/ alcohol abuse
* Legal incapacity or limited contractual capacity Medical or psychological condition which in the opinion of the investigator would not permit the patient to complete the study or sign meaningful informed consent

Primary outcomes:
measure: Reduction in the chemotherapy-associated steatosis
timeFrame: up to 24 weeks
Secondary outcomes:
measure: Progression Free Survival
timeFrame: up to 30 months
measure: Overall Survival
timeFrame: up to 30 months
measure: Safety assessment of all randomized subjects with at least one administration of study treatment
timeFrame: up to 24 weeks
measure: Occured Adverse Events of all randomized subjects with at least one administration of study treatment
timeFrame: up to 30 months
measure: Objective response rate (CR/PR)
timeFrame: up to 24 weeks
measure: Reduction in chemo-therapy associated steatohepatitis (CASH)
timeFrame: up to 24 weeks
Other outcomes:
Locations:
city: Graz
country: Austria
facility: Medical University Graz, Oncology
state: Styria
city: Innsbruck
country: Austria
facility: Medical University Innsbruck, Internal Medicine
state: Tyrol
city: Zams
country: Austria
facility: Hospital St. Vinzenz
state: Tyrol
city: Ried
country: Austria
facility: Hospital BHS Ried
state: Upper Austria
city: Vienna
country: Austria
facility: KH BHB Vienna
city: Vienna
country: Austria
facility: Med. Univ. Vienna, General Hospital Vienna
city: Vienna
country: Austria
facility: KH St. Josef KH
Study officials:
affiliation: Austrian Breast & Colorectal Cancer Study Group
name: Birgit Gruenberger, MD
role: PRINCIPAL_INVESTIGATOR
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