louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06955858: Clinical Study of rhTPO in Hematopoietic Stem Cell Mobilization for Autologous Transplantation in Acute Leukemia
Official title: Recombinant Human Thrombopoietin for Autologous Hematopoietic Stem Cell Mobilization in Acute Leukemia: A Single-Arm Prospective Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Hematopoietic Stem Cell Mobilization
Keywords: Recombinant Human Thrombopoietin
Lead sponsor: Institute of Hematology & Blood Diseases Hospital, China
Sponsor class: OTHER
First posted: 2025-05-02
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Evaluation of the efficacy and safety of recombinant human thrombopoietin (rhTPO) at 300 U/kg/day for hematopoietic stem cell mobilization in autologous transplantation among acute leukemia patients


Eligibility criteria: Inclusion Criteria:

1. Age 18～65 years, regardless of gender.
2. Histopathologically confirmed acute leukemia with immunohistochemical validation
3. Sustained complete hematologic remission with documented minimal residual disease (MRD) negativity.
4. Eastern Cooperative Oncology Group (ECOG) performance status smaller than 2 and a life expectancy of more than 6 months
5. No active infectious disease; no severe organ failure.
6. Willingness to participate with written informed consent for study enrollment.

Exclusion Criteria:

1. Liver dysfunction (alanine aminotransferase or bilirubin greater than two times the normal upper limit).
2. Renal dysfunction (creatinine or urea higher than 1.5 times the normal upper limit).
3. Any disease that could put patients at high risk, including but not limited to unstable cardiac disease, uncontrolled atrial fibrillation or hypertension, severe diabetic retinopathy
4. rhTPO aller- gies.
5. Severe prior thrombosis-event.
6. History of other malignancy, unless cured for more than 3 years
7. Pregnant or lactating women
8. Severe infectious disease (uncured tuberculosis, pulmonary aspergillosis)
9. Epilepsia, dementia or any mental disease requiring treatment.
10. Other conditions deemed inappropriate for study participation by the investigator.

Primary outcomes:
measure: total CD34+ cell count
timeFrame: two weeks
Secondary outcomes:
measure: the proportion of patients collecting more than or equal to 2*10^6 CD34+ cells/kg
timeFrame: two weeks
measure: the proportion of patients collecting more than or equal to 5*10^6 CD34+ cells/kg
timeFrame: two weeks
measure: total mononuclear cell count
timeFrame: two weeks
measure: time of platelet engraftment
timeFrame: eight weeks
measure: time of neutrophil engraftment
timeFrame: four weeks
Other outcomes:
Locations:
city: Tianjin
country: China
facility: Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences
Study officials:
References:
Clinical trial NCT00488358: Hemodynamic Changes After Aortic Aneurysm Treatment With Stent-Graft
Official title: Hemodynamic Changes After Aortic Aneurysm Treatment With Stent-Graft
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Keywords: abdominal
aortic
aneurysm
Zenith
blood pressure
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
First posted: 2007-06-20
Enrollment: 10
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Abdominal Aortic Aneurysm with planned treatment using Zenith Endovascular Stent-Graft

Brief summary: To compare the aortic pulse profile before and after stent-graft implantation to prove that endovascular AAA repair using non-compliant stent-graft changes the aortic pulse profile.

Detailed description: This study will assess hemodynamic changes in aortas of patients after treatment of their abdominal aortic aneurysm (AAA) with an FDA approved stent-graft (Zenith). This study does not require any change in clinical protocol to the the way the AAA procedures are currently done. Utilizing the catheters already employed in this procedure, intravascular blood pressure measurements will be documented at various times and at various anatomic levels prior to and after deployment of the stent-graft.

As the compliant aortic aneurysm acts as a capacitor, expanding during systole and contracting during diastole, it is our hypothesis that endovascular AAA repair using a non-compliant stent-graft changes the aortic pulse profile.

Eligibility criteria: Inclusion Criteria:

* Abdominal Aortic Aneurysm with planned treatment using Zenith Endovascular Stent-Graft

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: Division of Vascular Surgery, UCSF
state: California
Study officials:
affiliation: Assistant Professor in Residence
name: Jade S Hiramoto, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT07010458: Exploring Acne Treatments Through Clinical Research Participation
Official title: Advancing Acne Care - Clinical Trials Open for Patient Enrollment
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Acne
Keywords: Acne
Lead sponsor: Power Life Sciences Inc.
Sponsor class: INDUSTRY
First posted: 2025-06-08
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with acne who are actively considering enrolling in a clinical trial for said condition, but have not yet completed enrollment and randomization phases.

Brief summary: The purpose of this study is to understand the lived experiences of acne patients enrolled in a related clinical trial testing a particular treatment. The primary focus will be on tracking trial adherence and dropout rates to enhance future research and care approaches, especially for underserved groups.


Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with acne.
* Aged ≥ 18 years old and ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed
* Subjects willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examination.

Exclusion Criteria:

* Refusal of consent
* Women of childbearing potential without a negative pregnancy test; or women who are lactating.
* Any serious and/or unstable pre-existing medical disorders

Primary outcomes:
measure: Rate of patients who decide to enroll in an acne clinical research.
timeFrame: 3 month
measure: Number of acne study participants who remain in clinical study until completion.
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: Power Life Sciences
state: California
Study officials:
affiliation: Power Life Sciences Inc.
name: Michael B Gill
role: STUDY_DIRECTOR
References:
citation: Eichenfield DZ, Sprague J, Eichenfield LF. Management of Acne Vulgaris: A Review. JAMA. 2021 Nov 23;326(20):2055-2067. doi: 10.1001/jama.2021.17633.
citation: Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet. 2012 Jan 28;379(9813):361-72. doi: 10.1016/S0140-6736(11)60321-8. Epub 2011 Aug 29.
citation: Titus S, Hodge J. Diagnosis and treatment of acne. Am Fam Physician. 2012 Oct 15;86(8):734-40.
Clinical trial NCT01454258: Indication for Intraoperative Volume Therapy
Official title: Indication for Intraoperative Volume Therapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Patients Undergoing Any Kind of Surgery
Lead sponsor: Johann Wolfgang Goethe University Hospital
Sponsor class: OTHER
First posted: 2011-10-18
Enrollment: 10100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients of participating hospitals that will undergo surgery and receive intravenous fluid or volume treatment(cristalloid or colloid) will be included.

Participating hospitals are the university teaching hospitals of the Goethe University Hospital

Brief summary: This study evaluates which substitution solutions are used in daily clincal practice in various teaching hospitals in a specific district (Frankfurt/Rhine-Main Metropolitan Region). Furthermore the indication for usage of these solutions is investigated.


Eligibility criteria: Inclusion Criteria:

* patients undergoing surgery receiving at least one bag of cristalloid or colloid solution

Exclusion Criteria:

* decline of participation

Primary outcomes:
measure: Number of Different Substitution Solutions Administered
timeFrame: 24h
Secondary outcomes:
Other outcomes:
Locations:
city: Frankfurt am Main
country: Germany
facility: Goethe University Hospital
state: Hessen
Study officials:
affiliation: Johann Wolfgang Goethe University Hospital
name: Kai Zacharowski, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02498158: Functional Neural Connectivity at Rest as a Diagnostic Tool for Intolerance to Heat
Official title: Functional Neural Connectivity at Rest, as a Diagnostic Tool for Intolerance to Heat and Return to Duty After Exertional Heat Stroke
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Functional Neural Connectivity
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2015-07-15
Enrollment: 20
Sex: MALE
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: population of soldiers from the israeli defence forces (IDF), healthy in general, who had gone through heat injury (heat fatigue or hyperthermia) in the two month prior to their recruitment.

Brief summary: Functional neural connectivity at rest of 3 groups (heat tolerant, heat intolerant and healthy subjects) will be assessed using the anatomical and functional MRI scans and compared.

Detailed description: 20 healthy subjects that had already underwent Heat Tolerance Test (HTT) at the Heller Institute of Medical Research (Sheba Medical Center) will be recruited and divided into 2 groups: heat tolerant and heat intolerant (according to the HTT results). They will be asked to arrive to one experimental day at the imaging department in Sheba Medical Center and undergo anatomical and functional MRI scans.

Third group will consist of 10 existing brain scans (separated from personal details) of healthy males, at the same age range and who had never gone through heat injury.

Data will be analysed by fMRI expert in order to compare the functional neural connectivity at rest between the three groups.

Eligibility criteria: Inclusion Criteria:

* generally healthy subjects
* underwent heat injury in the past two months
* underwent Heat Tolerance Test at the Heller Institute of Medical research

Exclusion Criteria:

* drug or alcohol use
* history of neurological disorders, mental retardation or head injury
* history or diagnosis of psychiatric disorders
* claustrophobia

Primary outcomes:
measure: functional neural connectivity
timeFrame: one day
Secondary outcomes:
Other outcomes:
Locations:
city: Tel-Hashomer
country: Israel
facility: Sheba medical center
state: Ramat- Gan
Study officials:
affiliation: Sheba Medical Center
name: Ofir Frenkel, M.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06847958: HepC Micro-elimination on MSM and TGW Population.
Official title: HepC Micro-elimination on MSM Comunity
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hepatitis C
PrEP
Drugs of Abuse
Keywords: MSM
TGW
PrEP
Hepatitis C Transmision
micro-elimination
Lead sponsor: Projecte dels NOMS Hispanosida
Sponsor class: OTHER
Collaborators: name: Fundació Lluita contra les Infeccions
name: Germans Trias i Pujol Hospital
First posted: 2025-02-26
Enrollment: 13161
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Men who have sex with other men or transgender women, that are HIV negative and comes to get tested in our center or are under controls in our center. Estimated enrollment first Phase 6000-7000 participants. Second phase 2000-3000 participants.

Brief summary: This is an observational study, in which a single visit will be carried out, which includes a questionnaire on sexual habits and in which the possibility of carrying out a screening for Hepatitis C will be offered. Depending on the score obtained in the questionnaire, the screening will be carried out using a rapid serology test or viral load. During the first year, a SCORE will be developed to classify the risk of positive results. This SCORE will be used during phase 2 to offer users of the centres a targeted screening based on the Pre-test score.


Eligibility criteria: Inclusion Criteria:

1. All BCN Checkpoint and BCN PreP·Point clients.
2. 18 years and older.
3. HIV uninfected or diagnosticated in the center in the last 7 days prior to the study inclusion.
4. Men that have sex with men or transgender women.
5. Signature of written consent form.
6. Ability to comply with the requirements of the study protocol.

Exclusion Criteria:

1. Knowledge of HIV infection from more than 7 days
2. Knowledge of active HCV infection

Primary outcomes:
measure: Hepatitis C active infection
timeFrame: August 2021 o September 2023
Secondary outcomes:
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: BCN checkpoint
Study officials:
References:
Clinical trial NCT04901858: Knee Aspiration and High Definition MRI for ACL Injury
Official title: Pilot Study Into the Structural Local Molecular Environment Following an ACL Injury
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: ACL Injury
Lead sponsor: Cambridge University Hospitals NHS Foundation Trust
Sponsor class: OTHER
First posted: 2021-05-26
Enrollment: 5
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this pilot study is to understand the biological changes that occur within the knee joint following injury to the anterior cruciate ligament (ACL). This will be achieved through aspiration and analysis of the haemarthrosis which fills the knee following injury. The study will look at inflammatory and healing responses using DNA, RNA and protein analysis.

This, combined with high resolution imaging of the knee and surrounding soft tissue structures, may enable a more patient specific approach to treatment of ACL injury.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of ACL injury confirmed by MRI
* All participants must have the capacity to provide informed consent to participate
* Participants must be able to comply with required study visit

Exclusion Criteria:

* Participants outside of the specified age range
* Participants who do not have the mental capacity to make informed decisions
* Participants who have meniscal pathology or other injuries requiring urgent surgery

Primary outcomes:
measure: Pattern of injury on High Definition MRI measured by comparison with 3t MRI images
timeFrame: Last visit, usually 28 days
Secondary outcomes:
measure: Identification of acute inflammatory mediators measured by NanoString molecular analysis
timeFrame: Last visit, usually 28 days
Other outcomes:
Locations:
city: Cambridge
country: United Kingdom
facility: Cambridge University Hospitals NHS Foundation Trust
Study officials:
References:
Clinical trial NCT02452658: Fast Food Photo Study 2
Official title: Detecting Changes on Fast Food Menu
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Keywords: Fast food literacy
Lead sponsor: Carnegie Mellon University
Sponsor class: OTHER
First posted: 2015-05-22
Enrollment: 311
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Participants will be exposed to a hypothetical fast food menu, asked to place a hypothetical lunch order, and will then be exposed to a second menu with several changes made to the menu. Participants will be asked to identify as many changes as possible on this second menu, and then complete a survey about their eating tendencies and demographics.

Detailed description: The menu with changes will feature changes to both calories and prices, allowing for measures of whether participants notice such changes and the order in which changes are noticed.

Eligibility criteria: Inclusion Criteria:

* 18 or older,
* agrees to consent form

Exclusion Criteria:

* N/A

Primary outcomes:
measure: Number of participants who notice calorie change
timeFrame: Participants will have 2 minutes to notice changes on the menu
measure: Number of participants who notice price change
timeFrame: Participants will have 2 minutes to notice changes on the menu
Secondary outcomes:
measure: Within-participant ranking of the order in which changes were noticed
timeFrame: Participants will have 2 minutes to notice changes on the menu
measure: Total number of changes noticed
timeFrame: Participants will have 2 minutes to notice changes on the menu
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: Carnegie Mellon University
state: Pennsylvania
Study officials:
affiliation: Graduated PhD Candidate
name: Eric M VanEpps, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01840358: Hypoglycemia at Initiation of Pump Therapy in Children With Type 1 Diabetes
Official title: Evaluation of the Frequency of Hypoglycemia at Initiation of Insulin Pump Therapy in Children With Type 1 Diabetes
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Type 1 Diabetes
Keywords: Hypoglycemias
Insulin pump
Children
Lead sponsor: St. Justine's Hospital
Sponsor class: OTHER
First posted: 2013-04-25
Enrollment: 30
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP

Brief summary: The purpose of this study is to determine if patients have more hypoglycemic episodes the first 3 days following pump start compared to their usual number of hypoglycemias with our actual pump initiation protocol.


Eligibility criteria: Inclusion Criteria:

* Patients with type 1 diabetes with follow-up at the CHU Sainte-Justine
* Patient about to start insulin pump therapy at the CHU Sainte-Justine
* Last HbA1c between 7.2 and 9.7%
* Informed and signed consent

Exclusion Criteria:

* Type 1 diabetes diagnosed less than 1 year ago WITH total daily dose of insulin \< 0.5U/kg/day
* Home of the patient at more than 50km of the CHU Sainte-Justine
* Refusal to consent

Primary outcomes:
measure: Frequency of hypoglycemias
timeFrame: 6 days
Secondary outcomes:
measure: Frequency of hyperglycemias
timeFrame: 6 days
Other outcomes:
Locations:
city: Montreal
country: Canada
facility: CHU Sainte-Justine
state: Quebec
Study officials:
affiliation: St. Justine's Hospital
name: patricia Olivier, Md
role: PRINCIPAL_INVESTIGATOR
References:
citation: Manousaki D, Deladoey J, Geoffroy L, Olivier P. Continuous Subcutaneous Insulin Infusion in Children: A Pilot Study Validating a Protocol to Avoid Hypoglycemia at Initiation. Front Endocrinol (Lausanne). 2017 Apr 24;8:84. doi: 10.3389/fendo.2017.00084. eCollection 2017.
Clinical trial NCT02500758: Effectiveness of Preoperative Surgical Scrubbing Using Clorhexidine Digluconate and Parachlorometaxylenol (ECP)
Official title: Effectiveness of Preoperative Surgical Scrubbing in Reducing Bacterial Load, Using Chlorhexidine Digluconate (CHX) and Parachlorometaxylenol (PCMX)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Skin Diseases
Surgical Site Infection
Keywords: Surgical scrubbing
Chlorhexidine digluconate
Parachlorometaxylenol
Lead sponsor: Universidad Complutense de Madrid
Sponsor class: OTHER
First posted: 2015-07-16
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: Despite the wide variety of products and antiseptic agents, no agent is ideal for every situation. The investigators would like to evaluate the difference in reducing bacterial load, using 4% chlorhexidine digluconate and 3% parachlorometaxylenol after a preoperative surgical scrubbing.

Detailed description: The investigators conducted a controlled, prospective, randomized study to evaluate the antiseptic effectiveness of preoperative surgical scrubbing using 4% chlorhexidine digluconate and 3% parachlorometaxylenol. Samples were taken from the hands of each volunteer after a preparatory handwash, pre-surgical scrubbing, post-surgical scrubbing and 3 hours after surgical scrubbing.

Eligibility criteria: Inclusion Criteria:

* No systemic diseases.
* Healthy skin on hands, without cuts or abrasions.
* Short and clean fingernails.
* No use of substances with antimicrobial action (e.g. medicated soaps or creams).

Exclusion Criteria:

* History of eczema.
* History of psoriasis.
* Allergies to any of the ingredients of the solutions or contraindication to its use.

Primary outcomes:
measure: Change in the Release of Skin Flora From the Hands From Baseline to 5 Minutes After Disinfection by Surgical Scrubbing (Time Frame- "Baseline and 5 Minutes").
timeFrame: 5 minutes
Secondary outcomes:
measure: Change in the Release of Skin Flora From the Hands From Baseline to 3 Hours After Surgical Scrub Disinfection, Wearing Surgical Gloves (Time Frame- "Baseline and 3 Hours").
timeFrame: 3 hours
Other outcomes:
Locations:
Study officials:
affiliation: Universidad Complutense de Madrid
name: Ricardo Becerro de Bengoa Vallejo, DPM
role: PRINCIPAL_INVESTIGATOR
References:
citation: Becerro de Bengoa Vallejo R, Losa Iglesias ME, Cervera LA, Fernandez DS, Prieto JP. Efficacy of intraoperative surgical irrigation with polihexanide and nitrofurazone in reducing bacterial load after nail removal surgery. J Am Acad Dermatol. 2011 Feb;64(2):328-35. doi: 10.1016/j.jaad.2010.01.011. Epub 2010 Nov 26.
citation: Vallejo RBB, Fernandez DS, Cervera LA, Aragon LM, Iglesias MEL, Yurrita LRC, Lopez DL. Effectiveness of surgical hand antisepsis using chlorhexidine digluconate and parachlorometaxylenol hand scrub: Cross-over trial. Medicine (Baltimore). 2018 Oct;97(42):e12831. doi: 10.1097/MD.0000000000012831.