Clinical trial NCT06958965: Resistance Exercise Training on Vascular and Physical Function in Postmenopausal Women
Official title: Effects of Resistance Exercise Training on Vascular Function and Physical Performance in Postmenopausal Women
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Postmenopausal Women
Keywords: exercise
cardiovascular diseases
arteries
arterial compliance
hormones
estrogen
Lead sponsor: National Yang Ming Chiao Tung University
Sponsor class: OTHER
First posted: 2025-05-06
Enrollment: 32
Sex: FEMALE
Minimum age (years): 55
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Postmenopausal women often face risks of vascular dysfunction and muscle deterioration due to estrogen deficiency. These changes significantly increase the risk of cardiovascular disease and mortality. Previous studies have shown a significant positive correlation between vascular endothelial function and muscle strength. Moreover, muscle strength is a stronger predictor of mortality than muscle mass and is closely associated with the maintenance of functional independence in daily life. However, studies investigating the effects of whole-body progressive resistance training on vascular function and physical performance in postmenopausal women remain limited. This study aims to examine changes in vascular function and muscle strength in postmenopausal women following a whole-body progressive resistance training program.


Eligibility criteria: Inclusion Criteria:

Participants were eligible for the study if they met the following criteria:

1. Postmenopausal women aged between 55 and 70 years;
2. Body mass index (BMI) less than 30 kg/m²;
3. At least one year since menopause;
4. Able to live independently in the community;
5. Able to communicate independently in Mandarin or Taiwanese.

Exclusion Criteria:

Participants were excluded if they met any of the following conditions:

1. Acute musculoskeletal injuries within the past month (e.g., acute inflammation, fractures, sprains, contusions, or joint implants);
2. Diagnosed central or peripheral nervous system disorders affecting exercise participation (e.g., stroke, dementia, Parkinson's disease, autonomic dysfunction);
3. History of serious cardiac conditions within the past six months (e.g., coronary stenting, pacemaker implantation, peripheral or cerebral vascular reconstruction);
4. Presence of peripheral vascular diseases (e.g., peripheral artery disease, venous thrombosis);
5. Hormone therapy within the past six months;
6. Currently taking beta-blockers, anti-inflammatory drugs, or anticoagulant medications;
7. Currently participating in any other structured exercise training programs.

Primary outcomes:
measure: Flow-mediated dilation-endothelial function
timeFrame: Change from baseline at 12 weeks
measure: Brachial-ankle plus wave velocity (baPWV)-arterial stiffness
timeFrame: Chang from baseline at 12 weeks
Secondary outcomes:
measure: Hand grip strength- muscle strength
timeFrame: Change from baseline at 12 weeks
measure: Five-repetition maximum test (5RM)
timeFrame: Change from baseline at 12 weeks
measure: Body Composition
timeFrame: Change from baseline at 12 weeks
measure: Perceived Exertion
timeFrame: Change from baseline at 12 weeks
measure: International Physical Activity Questionnaire (IPAQ) - Taiwan Physical Activity Questionnaire (Short Form)
timeFrame: Change from baseline at 12 weeks
measure: Short Physical Performance Battery (SPPB)
timeFrame: Change from baseline at 12 weeks
measure: 3-Meter Walk Test
timeFrame: Change from baseline at 12 weeks
measure: 30-Second Chair Stand Test:
timeFrame: Change from baseline at 12 weeks
Other outcomes:
Locations:
Study officials:
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