Clinical trial NCT06848712: Brain Structural Abnormalities in Patients With Vertigo
Official title: Brain Structural Abnormalities in Patients With Vertigo
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Vertigo
MRI
Keywords: vertigo
MRI
white matter lesions
Circle of Willis
sinusitis
BPPV
lifestyle modifications
betahistine
Lead sponsor: University of Pecs
Sponsor class: OTHER
First posted: 2025-02-27
Enrollment: 464
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population consisted of adult patients (≥18 years) with vertigo who were referred for brain MRI to investigate potential structural abnormalities. A control group of individuals without a history of vertigo or neurological disorders was included for comparison. Exclusion criteria included prior neurological diseases, recent head trauma, and MRI contraindications.

Brief summary: Introduction: Dizziness is one of the most common complaints in medical practice and is associated with various underlying conditions, including neurological, otolaryngological, and psychological disorders. Preliminary imaging studies like CT, cervical spine X-rays, and carotid/vertebral artery ultrasound, aids in precise diagnosis and targeted therapeutic decisions. MRI is one of the most effective imaging modalities currently available for examining the brain.

Purpose: To identify structural brain changes linked to vertigo, explore pre-MRI diagnostic approaches, and evaluate treatment strategies.

Methods: The study included 232 patients with vertigo and 232 control subjects. MRI results were categorized, and pre-MRI examinations, symptoms, and treatments were analyzed. Statistical comparisons were conducted using chi-square and t-tests, with significance set at p\<0.05.

Detailed description: Vertigo is a prevalent symptom with multiple underlying etiologies, including neurological, vascular, and musculoskeletal causes. Despite its high prevalence, the exact structural brain abnormalities associated with vertigo remain unclear. This observational study aims to assess brain MRI findings in patients with vertigo and compare them to a control group without vertigo symptoms. The study also evaluates pre-MRI diagnostic procedures, such as vertebral/carotid ultrasound and cervical spine X-rays, to identify potential vascular and musculoskeletal contributors to vertigo. The results may provide insights into the structural brain changes linked to vertigo and help refine diagnostic and treatment strategies.

Eligibility criteria: Inclusion Criteria:

* Age ≥18 years
* Reported dizziness (vertigo) as a primary symptom
* Brain MRI requested by the attending physician

Exclusion Criteria:

* Prior neurological disease or disorder (other than vertigo/dizziness in the vertigo group)
* MRI contraindications (e.g., pacemaker, metal implants, claustrophobia)

Primary outcomes:
measure: Occurrences With Specific Structural Brain Abnormalities Observed on MRI
timeFrame: From September 2020 to December 2022
Secondary outcomes:
measure: Occurrences of associated symptoms in vertigo patients
timeFrame: From September 2020 to December 2022
measure: Occurrences of pre-MRI diagnostic procedures in vertigo patients
timeFrame: From September 2020 to December 2022
measure: Occurrences of post-MRI diagnoses in vertigo patients
timeFrame: From September 2020 to December 2022
measure: Occurrences of treatment strategies applied
timeFrame: From September 2020 to December 2022
Other outcomes:
Locations:
city: Budapest
country: Hungary
facility: Szent Margit Hospital
Study officials:
affiliation: University of Pécs, Faculty of Health Sciences, Hungary
name: Klaudia Széphelyi
role: PRINCIPAL_INVESTIGATOR
References: