Clinical trial NCT02819635: A Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Official title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Ulcerative Colitis (UC)
Keywords: Upadacitinib (ABT-494)
Moderately to Severely Active UC
RINVOQ
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2016-06-30
Enrollment: 1302
Sex: ALL
Minimum age (years): 16
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study was comprised of three substudies. The objective of Substudy 1 was to characterize the dose-response, efficacy, and safety of upadacitinib compared to placebo in inducing clinical remission to identify the induction dose of upadacitinib for further evaluation in Substudy 2. The objective of Substudy 2 was to evaluate the efficacy and safety of upadacitinib compared to placebo in inducing clinical remission in participants. The objective of Substudy 3 was to evaluate the efficacy and safety of upadacitinib compared to placebo in achieving clinical remission in participants who had a response following induction with upadacitinib.

Detailed description: Substudy 1 was a Phase 2b dose-ranging study designed to evaluate the efficacy and safety of different oral doses of upadacitinib compared to placebo as 8-week induction therapy in participants with moderately to severely active UC. Approximately 250 participants were planned to be randomized 1:1:1:1:1 to the placebo group and 4 upadacitinib doses (7.5, 15, 30, and 45 mg). Randomization was stratified by previous biologic therapy use (yes/no), Baseline corticosteroid use (yes/no), and Baseline Adapted Mayo score (≤ 7 or \> 7). The study duration included a Screening Period of up to 5 weeks and an 8-week double-blind (DB) Induction Period. After all randomized participants completed the 8-week induction, a dose-selection analysis of efficacy and safety (selected laboratory parameters) of upadacitinib versus placebo was performed. Based on this dose-selection analysis, one induction dose (upadacitinib 45 mg) was identified for further evaluation in two Phase 3 induction studies, M14-234 Substudy 2 and M14-675 (NCT03653026). During the analysis period, 132 additional participants were randomized into Groups 3 and 4 of Substudy 1 (upadacitinib 30 mg and 45 mg dose groups; approximately 66 participants per dose group). The objectives of enrolling these additional participants were to avoid interrupting the study activities during the analysis period and to support a sufficient number of participants with clinical response to be re-randomized into the maintenance portion in Substudy 3. Substudy 1 main participants are defined as those first 250 randomized 250, and additional participants are defined as those who were randomized after the main participants.

Substudy 2 was a two-part Phase 3 dose-confirming study designed to evaluate the efficacy and safety of oral administration of upadacitinib 45 mg compared to placebo as induction therapy for up to 16 weeks in participants with moderately to severely active UC. Substudy 2 included a Screening Period of up to 5 weeks, Part 1, and Part 2. Part 1 was a randomized, DB, placebo-controlled 8-week induction period. Part 2 was an open-label, 8-week extended treatment period for clinical non-responders from Part 1 of Substudy 2. Part 1 was planned to enroll 462 subjects; actual enrollment was 474 subjects. Eligible participants were randomized in a 2:1 ratio to one of the two treatment groups (DB upadacitinib 45 mg or matching placebo) for 8 weeks. The randomization was stratified by bio-IR status (Biologic inadequate responders \[bio-IR\] vs Non-biologic-inadequate responders \[non-bio-IR\], corticosteroid use (yes or no), and Adapted Mayo score (≤ 7 or \> 7) at Baseline. Within bio-IR, the randomization was further stratified by number of prior biologic treatments (≤ 1 or \> 1). Within non-bio-IR, the randomization was further stratified by previous biologic use (yes or no). Part 2 was an open label, 8-week Extended Treatment Period for those who did not achieve clinical response per Adapted Mayo score at Week 8 in Part 1. All participants received upadacitinib 45 mg.

Substudy 3 was a Phase 3 maintenance study designed to evaluate the efficacy and safety of upadacitinib 15 and 30 mg once daily (QD) compared to placebo in achieving clinical remission per Adapted Mayo score in participants with moderately to severely active UC who achieved clinical response per Adapted Mayo score following induction therapy from Substudy 1, Substudy 2, or Study M14-675. A total of 1,046 subjects who achieved clinical response per Adapted Mayo score after completion of induction treatment or Extended Treatment Period in Study M14-234 Substudy 1, Substudy 2, or Study M14-675 entered Substudy 3, and 1,044 were treated with a blinded treatment assignment for up to 52 weeks. Substudy 3 included 4 cohorts. Cohort 1: 847 participants who achieved clinical response in Substudy 1, Substudy 2, or Study M14-675 at either Week 8 or Week 16, and received upadacitinib 15, 30, or 45 mg QD. The treatment groups in Cohort 1 were Group 1: upadacitinib 15 mg QD; Group 2: upadacitinib 30 mg QD; and Group 3: placebo QD. Those who achieved clinical response and received upadacitinib 15 mg QD in Substudy 1 were re-randomized 1:1 to only receive upadacitinib 15 mg QD or placebo QD (treatment Group 1 or 3). Cohort 2: 104 participants who received double-blind placebo QD treatment for 8 weeks during Substudy 1, Substudy 2 Part 1, or Study M14-675 Part 1 and achieved clinical response at Week 8 continued to receive blinded placebo QD in Substudy 3. Cohort 3: 75 participants who received upadacitinib 45 mg QD in Induction Phase and did not achieve clinical response and received upadacitinib 45 mg QD in Extended Treatment in Substudy 2 Part 2 or in Study M14-675 Part 2 and achieved clinical response at Week 16 were re-randomized 1:1 and received blinded upadacitinib 30 mg QD or upadacitinib 15 mg QD in Substudy 3. Cohort 4: 20 participants who received double-blinded treatment of upadacitinib 7.5 mg QD for 8 weeks during Substudy 1 and achieved clinical response at Week 8 continued to receive blinded treatment of upadacitinib 7.5 mg QD in Substudy 3.

Eligibility criteria: Inclusion Criteria:

Note: Adolescent participants who are 16 or 17 years old will be eligible to participate if approved by the country or regulatory/health authority. If approval has not been granted, only participants ≥18 years old will be enrolled. Adolescents must weigh ≥ 40 kilograms and meet the definition of Tanner Stage 5 at Screening Visit.

* Diagnosis of ulcerative colitis for 90 days or greater prior to Baseline, confirmed by colonoscopy during the Screening Period, with exclusion of current infection, colonic dysplasia and/or malignancy. Appropriate documentation of biopsy results consistent with the diagnosis of UC, in the assessment of the Investigator, must be available.
* Active ulcerative colitis with an Adapted Mayo score of 5 to 9 points and endoscopic sub score of 2 to 3 (confirmed by central reader).
* Demonstrated an inadequate response to, loss of response to, or intolerance to at least one of the following treatments including: oral aminosalicylates, corticosteroids, immunosuppressants, and/or biologic therapies in the opinion of the investigator.

Note: Participants who have had inadequate response, loss of response to conventional therapy, but have not failed biologic therapy (Non-bio-IR) and have received a prior biologic for up to 1 year may be enrolled, however they must have discontinued the biologic for reasons other than inadequate response or intolerance (e.g., change of insurance, well controlled disease) and must meet criteria for inadequate response, loss of response or intolerance to aminosalicylates, corticosteroids, and/or immunosuppressants as defined above.

* If female, participant must meet the criteria for Contraception Recommendations
* Female participants of childbearing potential must have a negative serum pregnancy test at the Screening Visit and a negative urine pregnancy test at the Baseline Visit prior to study drug dosing.

Exclusion Criteria:

* Participant with current diagnosis of Crohn's disease (CD) or diagnosis of indeterminate colitis (IC)
* Current diagnosis of fulminant colitis and/or toxic megacolon
* Participant with disease limited to the rectum (ulcerative proctitis) during the screening endoscopy
* Received cyclosporine, tacrolimus, mycophenolate mofetil, or thalidomide within 30 days prior to Baseline
* Participant on azathioprine or 6-mercaptopurine within 10 days of Baseline
* Received intravenous corticosteroids within 14 days prior to Screening or during the Screening Period.
* Participant with previous exposure to Janus Activated Kinase (JAK) inhibitor (e.g., tofacitinib, baricitinib, filgotinib, upadacitinib).
* Screening laboratory and other analyses show any abnormal results meeting the exclusion criteria

Primary outcomes:
measure: Substudy 1: Percentage Of Participants Who Achieved Clinical Remission Per Adapted Mayo Score at Week 8
timeFrame: At Week 8
measure: Substudy 2: Percentage Of Participants Who Achieved Clinical Remission Per Adapted Mayo Score at Week 8
timeFrame: At Week 8
measure: Substudy 3: Percentage Of Participants Who Achieved Clinical Remission Per Adapted Mayo Score at Week 52
timeFrame: At Week 52
Secondary outcomes:
measure: Substudy 1: Percentage Of Participants With Endoscopic Improvement at Week 8
timeFrame: At Week 8
measure: Substudy 1: Percentage Of Participants Achieving Clinical Remission Per Full Mayo Score at Week 8
timeFrame: At Week 8
measure: Substudy 1: Percentage Of Participants Achieving Clinical Response Per Adapted Mayo Score at Week 8
timeFrame: At Week 8
measure: Substudy 1: Percentage Of Participants Achieving Clinical Response Per Partial Mayo Score at Week 2
timeFrame: At Week 2
measure: Substudy 1: Change in Full Mayo Score From Baseline to Week 8
timeFrame: Baseline (Week 0), Week 8
measure: Substudy 1: Percentage Of Participants With Endoscopic Remission at Week 8
timeFrame: At Week 8
measure: Substudy 1: Percentage Of Participants Who Achieved Histologic Improvement at Week 8
timeFrame: At Week 8
measure: Substudy 2: Percentage Of Participants With Endoscopic Improvement at Week 8
timeFrame: At Week 8
measure: Substudy 2: Percentage Of Participants With Endoscopic Remission at Week 8
timeFrame: At Week 8
measure: Substudy 2: Percentage Of Participants Achieving Clinical Response Per Adapted Mayo Score at Week 8
timeFrame: At Week 8
measure: Substudy 2: Percentage Of Participants Achieving Clinical Response Per Partial Mayo Score at Week 2
timeFrame: At Week 2
measure: Substudy 2: Percentage Of Participants Who Achieved Histologic-Endoscopic Mucosal Improvement at Week 8
timeFrame: At Week 8
measure: Substudy 2: Percentage Of Participants Who Report No Bowel Urgency at Week 8
timeFrame: At Week 8
measure: Substudy 2: Percentage Of Participants Who Reported No Abdominal Pain at Week 8
timeFrame: At Week 8
measure: Substudy 2: Percentage Of Participants Who Achieved Histologic Improvement at Week 8
timeFrame: At Week 8
measure: Substudy 2: Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score at Week 8
timeFrame: Baseline (Week 0), Week 8
measure: Substudy 2: Percentage Of Participants With Mucosal Healing at Week 8
timeFrame: At Week 8
measure: Substudy 2: Change From Baseline in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Score at Week 8
timeFrame: Baseline (Week 0), Week 8
measure: Substudy 3: Percentage Of Participants With Endoscopic Improvement at Week 52
timeFrame: At Week 52
measure: Substudy 3: Percentage of Participants With Clinical Remission Per Adapted Mayo Score at Week 52 Among Those Who Achieved Clinical Remission at the End of the Induction Treatment
timeFrame: At Week 52
measure: Substudy 3: Percentage of Participants Who Achieved Clinical Remission Per Adapted Mayo Score at Wk 52 and Were Corticosteroid Free for ≥ 90 Days Immediately Preceding Wk 52 Among Those Who Achieved Clinical Remission at the End of the Induction Treatment
timeFrame: At Week 52
measure: Substudy 3: Percentage of Participants With Endoscopic Improvement at Wk 52 Among Those Who Achieved Endoscopic Improvement at the End of the Induction Treatment
timeFrame: At Week 52
measure: Substudy 3: Percentage Of Participants With Endoscopic Remission At Week 52
timeFrame: At Week 52
measure: Substudy 3: Percentage Of Participants Who Maintained Clinical Response Per Adapted Mayo Score at Wk 52 Among Those Who Achieved Clinical Response at the End of the Induction Treatment
timeFrame: At Week 52
measure: Substudy 3: Percentage Of Participants Who Achieved Histologic-Endoscopic Mucosal Improvement at Week 52
timeFrame: At Week 52
measure: Substudy 3: Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score at Week 52
timeFrame: Baseline (Week 0), Week 52
measure: Substudy 3: Percentage Of Participants With Mucosal Healing at Week 52
timeFrame: At Week 52
measure: Substudy 3: Percentage Of Participants Who Reported No Bowel Urgency at Week 52
timeFrame: At Week 52
measure: Substudy 3: Percentage Of Participants Who Reported No Abdominal Pain at Week 52
timeFrame: At Week 52
measure: Substudy 3: Change From Baseline in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Score at Week 52
timeFrame: Baseline (Week 0), Week 52
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Birmingham Gastroenterology Associates P.C /ID# 151276
state: Alabama
city: Mobile
country: United States
facility: East View Medical Research, LLC /ID# 171183
state: Alabama
city: Mobile
country: United States
facility: CB Flock Research Corporation /ID# 165980
state: Alabama
city: Chandler
country: United States
facility: Delsol Research Management, Ll /Id# 170131
state: Arizona
city: Mesa
country: United States
facility: Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211885
state: Arizona
city: Sun City
country: United States
facility: Arizona Arthritis & Rheumatology Research, PLLC /ID# 169822
state: Arizona
city: Tucson
country: United States
facility: Adobe Clinical Research LLC /ID# 155250
state: Arizona
city: Tucson
country: United States
facility: University of Arizona /ID# 150553
state: Arizona
city: Covina
country: United States
facility: Citrus Valley Gastroenterology /ID# 151914
state: California
city: Huntington Beach
country: United States
facility: Newport Huntington Medical Group /ID# 217005
state: California
city: La Jolla
country: United States
facility: UC San Diego Health System /ID# 155185
state: California
city: Los Alamitos
country: United States
facility: United Medical Doctors /ID# 207464
state: California
city: Los Angeles
country: United States
facility: TLC Clinical Research Inc /ID# 216829
state: California
city: Los Angeles
country: United States
facility: Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157080
state: California
city: Mission Hills
country: United States
facility: Facey Medical Foundation /ID# 203133
state: California
city: Murrieta
country: United States
facility: United Medical Doctors - Murrieta /ID# 151211
state: California
city: Oxnard
country: United States
facility: InSite Digestive Health Care - Oxnard /ID# 163414
state: California
city: Rialto
country: United States
facility: Inland Empire Clinical Trials, LLC /ID# 216038
state: California
city: San Diego
country: United States
facility: San Diego Clinical Trials /ID# 212120
state: California
city: San Diego
country: United States
facility: Medical Assoc Research Grp /ID# 169148
state: California
city: San Francisco
country: United States
facility: Univ of California San Francis /ID# 164581
state: California
city: Colorado Springs
country: United States
facility: Delta Waves, Inc. /ID# 151721
state: Colorado
city: Lone Tree
country: United States
facility: South Denver Gastroenterology /ID# 151223
state: Colorado
city: Wheat Ridge
country: United States
facility: Western States Clinical Res /ID# 158076
state: Colorado
city: Danbury
country: United States
facility: Western Connecticut Medical Group /ID# 169210
state: Connecticut
city: Hamden
country: United States
facility: Medical Research Center of CT /ID# 150482
state: Connecticut
city: Clearwater
country: United States
facility: Gastro Florida /ID# 155245
state: Florida
city: Doral
country: United States
facility: Moonshine Research Center, Inc /ID# 152533
state: Florida
city: Doral
country: United States
facility: Universal Axon Clinical Research /ID# 213461
state: Florida
city: Hialeah
country: United States
facility: Palmetto Research, LLC /ID# 151716
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research - Inverness /ID# 154064
state: Florida
city: Jacksonville
country: United States
facility: Encore Borland-Groover Clinical Research /Id# 170912
state: Florida
city: Kissimmee
country: United States
facility: SIH Research Mumtaz, Inc /ID# 163319
state: Florida
city: Maitland
country: United States
facility: Cfagi Llc /Id# 202017
state: Florida
city: Miami
country: United States
facility: University of Miami /ID# 215441
state: Florida
city: Miami
country: United States
facility: Advanced Pharma /ID# 151719
state: Florida
city: Miami
country: United States
facility: New Horizon Research Center /ID# 152474
state: Florida
city: Miami
country: United States
facility: Crystal Pharmacology Research /ID# 151841
state: Florida
city: Miami
country: United States
facility: Coral Research Clinic /ID# 150444
state: Florida
city: New Port Richey
country: United States
facility: Advanced Research Institute, Inc /ID# 163098
state: Florida
city: Orlando
country: United States
facility: Endoscopic Research, Inc. /ID# 151720
state: Florida
city: Orlando
country: United States
facility: Omega Research Maitland, LLC /ID# 200269
state: Florida
city: Tampa
country: United States
facility: Clinical Research Trials of Florida, Inc. /ID# 201790
state: Florida
city: Tampa
country: United States
facility: University of South Florida /ID# 214493
state: Florida
city: Tampa
country: United States
facility: AdventHealth Tampa /ID# 200272
state: Florida
city: Macon
country: United States
facility: Gastroenterology Associates of Central Georgia, LLC /ID# 165782
state: Georgia
city: Riverdale
country: United States
facility: Infinite Clinical Trials /ID# 215340
state: Georgia
city: Suwanee
country: United States
facility: Atlanta Gastroenterology Spec /ID# 150548
state: Georgia
city: Chicago
country: United States
facility: Next Innovative Clinical Research - Chicago /ID# 216060
state: Illinois
city: Chicago
country: United States
facility: The University of Chicago DCAM /ID# 150547
state: Illinois
city: Evanston
country: United States
facility: NorthShore University HealthSystem /ID# 150555
state: Illinois
city: Hoffman Estates
country: United States
facility: Northwest Health Care Associates /ID# 151590
state: Illinois
city: Urbana
country: United States
facility: Carle Foundation Hospital /ID# 151137
state: Illinois
city: Evansville
country: United States
facility: MediSphere Medical Research Center /ID# 152064
state: Indiana
city: Indianapolis
country: United States
facility: Indianapolis Gastroenterology /ID# 162901
state: Indiana
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics /ID# 157058
state: Iowa
city: Topeka
country: United States
facility: Cotton-O'Neil Clinical Res Ctr /ID# 167182
state: Kansas
city: Crestview Hills
country: United States
facility: Tri-State Gastroenterology /ID# 169811
state: Kentucky
city: Houma
country: United States
facility: Houma Digestive Health Special /ID# 151844
state: Louisiana
city: New Orleans
country: United States
facility: Nola Research Works, LLC /ID# 153356
state: Louisiana
city: Shreveport
country: United States
facility: Louisana Research Center, LLC /ID# 150446
state: Louisiana
city: Baltimore
country: United States
facility: University of Maryland Med Ctr /ID# 150449
state: Maryland
city: Columbia
country: United States
facility: Gastro Center of Maryland /ID# 200022
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital /ID# 165676
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 151140
state: Michigan
city: Ann Arbor
country: United States
facility: Huron Gastroenterology Assoc /ID# 152710
state: Michigan
city: Chesterfield
country: United States
facility: Clin Res Inst of Michigan, LLC /ID# 153027
state: Michigan
city: Southfield
country: United States
facility: Revival Research Institute, LLC /ID# 207280
state: Michigan
city: Troy
country: United States
facility: Center for Digestive Health /ID# 161984
state: Michigan
city: Wyoming
country: United States
facility: Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 157484
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic - Rochester /ID# 151677
state: Minnesota
city: Saint Paul
country: United States
facility: Minnesota Gastroenterology PA /ID# 151678
state: Minnesota
city: Jackson
country: United States
facility: University of Mississippi Medical Center /ID# 213139
state: Mississippi
city: Jackson
country: United States
facility: Southern Therapy and Advanced Research (STAR) LLC /ID# 170712
state: Mississippi
city: Saint Louis
country: United States
facility: Washington University-School of Medicine /ID# 150485
state: Missouri
city: Las Vegas
country: United States
facility: Las Vegas Medical Research /ID# 153044
state: Nevada
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center /ID# 150549
state: New Hampshire
city: Egg Harbor Township
country: United States
facility: AGA Clinical Research Associates, LLC /ID# 153040
state: New Jersey
city: Morristown
country: United States
facility: Atlantic Digestive Health Inst /ID# 150447
state: New Jersey
city: New Brunswick
country: United States
facility: Rutgers Robert Wood Johnson /ID# 155248
state: New Jersey
city: Albuquerque
country: United States
facility: Duplicate_University of New Mexico Department of Internal Medicine /ID# 214396
state: New Mexico
city: Bronx
country: United States
facility: Montefiore Medical Center - Moses Campus /ID# 150543
state: New York
city: Bronx
country: United States
facility: Advantage Clinical Trials /ID# 163938
state: New York
city: Brooklyn
country: United States
facility: NY Scientific /ID# 152707
state: New York
city: Great Neck
country: United States
facility: NYU Langone Long Island Clinical Research Association /ID# 155272
state: New York
city: New York
country: United States
facility: Columbia Univ Medical Center /ID# 163410
state: New York
city: North Massapequa
country: United States
facility: DiGiovanna Institute for Medical Education & Research /ID# 201533
state: New York
city: Poughkeepsie
country: United States
facility: Premier Medical Group - GI Division /ID# 153357
state: New York
city: Rochester
country: United States
facility: Gastoenterology Group of Rochester /ID# 151079
state: New York
city: Staten Island
country: United States
facility: Richmond University Medical Center /ID# 201859
state: New York
city: Asheville
country: United States
facility: Digestive Health Partners, P.A /ID# 167237
state: North Carolina
city: Charlotte
country: United States
facility: Atrium Health Carolinas Medical Center /ID# 156971
state: North Carolina
city: Charlotte
country: United States
facility: Charlotte Gastroenterology and Hepatology, PLLC /ID# 150545
state: North Carolina
city: Greenville
country: United States
facility: Atlantic Gastroenterology Clinical Research /ID# 151899
state: North Carolina
city: Winston-Salem
country: United States
facility: Clinical Trials of America /ID# 153448
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Medical Center /ID# 150448
state: North Carolina
city: Fargo
country: United States
facility: Plains Clinical Research Center, LLC /ID# 170290
state: North Dakota
city: Cincinnati
country: United States
facility: Consultants for Clinical Research /ID# 151679
state: Ohio
city: Cincinnati
country: United States
facility: University of Cincinnati /ID# 164582
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University /ID# 169416
state: Ohio
city: Columbus
country: United States
facility: Optimed Research, Ltd. /ID# 169696
state: Ohio
city: Dayton
country: United States
facility: Hometown Urgent Care and Resea /ID# 200065
state: Ohio
city: Englewood
country: United States
facility: Dayton Gastroenterology, Inc. /ID# 167631
state: Ohio
city: Mentor
country: United States
facility: Great Lakes Medical Research, LLC /ID# 201772
state: Ohio
city: Mentor
country: United States
facility: Ohio Clinical Research Partner /ID# 154068
state: Ohio
city: Oklahoma City
country: United States
facility: Hightower Clinical /ID# 216337
state: Oklahoma
city: Oklahoma City
country: United States
facility: Digestive Disease Specialists /ID# 201056
state: Oklahoma
city: Tulsa
country: United States
facility: Options Health Research, LLC /ID# 150554
state: Oklahoma
city: Tulsa
country: United States
facility: Healthcare Research Consultant /ID# 163100
state: Oklahoma
city: Portland
country: United States
facility: Northwest Gastroenterology Clinic /ID# 152527
state: Oregon
city: Sayre
country: United States
facility: Guthrie Medical Group, PC /ID# 150481
state: Pennsylvania
city: State College
country: United States
facility: Penn State Health Colonnade /ID# 150259
state: Pennsylvania
city: Charleston
country: United States
facility: Pharmacorp Clinical Trials /ID# 153354
state: South Carolina
city: Greenville
country: United States
facility: Gastroenterology Associates, P.A. of Greenville /ID# 150541
state: South Carolina
city: Germantown
country: United States
facility: Gastro One /ID# 151144
state: Tennessee
city: Johnson City
country: United States
facility: East Tennessee Research Institute /ID# 203610
state: Tennessee
city: Nashville
country: United States
facility: Quality Medical Research /ID# 203426
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center /ID# 153355
state: Tennessee
city: Arlington
country: United States
facility: TX Clinical Research Institute /ID# 151526
state: Texas
city: Baytown
country: United States
facility: Inquest Clinical Research /ID# 164635
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209947
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209804
state: Texas
city: Dallas
country: United States
facility: Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 200770
state: Texas
city: Garland
country: United States
facility: DHAT Research Institute /ID# 151218
state: Texas
city: Houston
country: United States
facility: Vilo Research Group Inc /ID# 212624
state: Texas
city: Houston
country: United States
facility: CliniCore International, LLC /ID# 152062
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine - Baylor Medical Center /ID# 150486
state: Texas
city: Houston
country: United States
facility: Centex Studies, Inc. - Houston /ID# 201216
state: Texas
city: Houston
country: United States
facility: GI Specialists of Houston /ID# 202327
state: Texas
city: Lubbock
country: United States
facility: Caprock Gastro Research, LLC /ID# 214754
state: Texas
city: San Antonio
country: United States
facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 201260
state: Texas
city: San Antonio
country: United States
facility: Southern Star Research Institute, LLC /ID# 169396
state: Texas
city: Sugar Land
country: United States
facility: Carl R. Meisner Medical Clinic /ID# 171061
state: Texas
city: Temple
country: United States
facility: Baylor Scott & White Center for Diagnostic Medicine /ID# 204499
state: Texas
city: Tyler
country: United States
facility: Tyler Research Institute, LLC /ID# 169146
state: Texas
city: Victoria
country: United States
facility: Gastro Health & Nutrition - Victoria /ID# 167761
state: Texas
city: Bountiful
country: United States
facility: HP Clinical Research /ID# 163939
state: Utah
city: Ogden
country: United States
facility: Advanced Research Institute /ID# 162624
state: Utah
city: Salt Lake City
country: United States
facility: Utah Gastroenternology - St. Mark's Office /ID# 163101
state: Utah
city: West Jordan
country: United States
facility: Velocity Clinical Research - Salt Lake City /ID# 163181
state: Utah
city: Franklin
country: United States
facility: Ctr for Gastrointestinal Healt /ID# 153360
state: Virginia
city: Leesburg
country: United States
facility: Emeritas Research Group, LLC /ID# 150258
state: Virginia
city: Bellevue
country: United States
facility: Washington Gastroenterology /ID# 163629
state: Washington
city: Seattle
country: United States
facility: Virginia Mason Medical Center /ID# 153026
state: Washington
city: Seattle
country: United States
facility: The Polyclinic /ID# 164369
state: Washington
city: Vancouver
country: United States
facility: The Vancouver Clinic, INC. PS /ID# 162333
state: Washington
city: Grafton
country: United States
facility: Aurora Medical Center - Grafto /ID# 151717
state: Wisconsin
city: Milwaukee
country: United States
facility: Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 151838
state: Wisconsin
city: Milwaukee
country: United States
facility: Medical College of Wisconsin /ID# 151843
state: Wisconsin
city: San Isidro
country: Argentina
facility: Cardio Alem /ID# 211280
state: Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Gedyt /ID# 210015
state: Ciuadad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Mautalen Salud e Investigacion /ID# 171173
state: Ciuadad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Hospital Britanico de Buenos Aires /ID# 209495
state: Ciuadad Autonoma De Buenos Aires
city: San Miguel de Tucuman
country: Argentina
facility: Sanatorio 9 de Julio /ID# 150189
state: Tucuman
city: Cordoba
country: Argentina
facility: Hospital Privado Univesitario /ID# 164185
city: Macquarie University
country: Australia
facility: Macquarie University Hospital /ID# 211951
state: New South Wales
city: South Brisbane
country: Australia
facility: Mater Misericordiae Limited /ID# 212685
state: Queensland
city: Southport
country: Australia
facility: Griffith University /ID# 211952
state: Queensland
city: Clayton
country: Australia
facility: Monash Medical Centre /ID# 150206
state: Victoria
city: Fitzroy Melbourne
country: Australia
facility: St Vincent's Hospital Melbourne /ID# 152472
state: Victoria
city: Murdoch
country: Australia
facility: Fiona Stanley Hospital /ID# 211640
state: Western Australia
city: Linz
country: Austria
facility: Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 150305
state: Oberoesterreich
city: Vienna
country: Austria
facility: Klinik Landstrasse /ID# 162866
state: Wien
city: Vienna
country: Austria
facility: Medizinische Universitaet Wien /ID# 150614
state: Wien
city: Salzburg
country: Austria
facility: Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 150306
city: Витебск
country: Belarus
facility: Vitebsk Regional Advanced Clin /ID# 169612
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven /ID# 150332
state: Vlaams-Brabant
city: Gent
country: Belgium
facility: AZ Maria Middelares /ID# 150331
city: Roeselare
country: Belgium
facility: AZ-Delta /ID# 150330
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska /ID# 150209
state: Republika Srpska
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska /ID# 150706
state: Republika Srpska
city: Tuzla
country: Bosnia and Herzegovina
facility: University Clinical Center Tuzla /ID# 150211
state: Tuzlanski
city: Mostar
country: Bosnia and Herzegovina
facility: University Clinical Hospital Mostar /ID# 150705
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center University of Sarajevo /ID# 150208
city: Goiânia
country: Brazil
facility: Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 153742
state: Goias
city: Curitiba
country: Brazil
facility: Hospital Nossa Senhora das Graças /ID# 152480
state: Parana
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre /ID# 153743
state: Rio Grande Do Sul
city: Botucatu
country: Brazil
facility: Upeclin Fmb - Unesp /Id# 152485
state: Sao Paulo
city: Ribeirão Preto
country: Brazil
facility: Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 152484
state: Sao Paulo
city: Santo André
country: Brazil
facility: Faculdade de Medicina do ABC /ID# 152481
state: Sao Paulo
city: Sao Jose Do Rio Preto
country: Brazil
facility: Kaiser Clinica e Hospital Dia /ID# 152483
state: Sao Paulo
city: Calgary
country: Canada
facility: University of Calgary /ID# 151821
state: Alberta
city: Edmonton
country: Canada
facility: Allen Whey Khye Lim Professional Corporation /ID# 211168
state: Alberta
city: Edmonton
country: Canada
facility: University of Alberta - Zeidler Ledcor Centre /ID# 151100
state: Alberta
city: Edmonton
country: Canada
facility: Covenant Health /ID# 158930
state: Alberta
city: Kelowna
country: Canada
facility: Okanagan Clinical Trials /ID# 153178
state: British Columbia
city: Victoria
country: Canada
facility: Percuro Clinical Research, Ltd /ID# 150367
state: British Columbia
city: Hamilton
country: Canada
facility: Hamilton Health Sciences - McMaster University Medical Centre /ID# 150365
state: Ontario
city: Ottawa
country: Canada
facility: Ottawa Hospital Research Institute /ID# 151820
state: Ontario
city: Sudbury
country: Canada
facility: Medicor Research Inc /ID# 151101
state: Ontario
city: Vaughan
country: Canada
facility: Toronto Digestive Disease Asso /ID# 150363
state: Ontario
city: Greenfield Park
country: Canada
facility: CISSS de la Monteregie /ID# 159215
state: Quebec
city: Levis
country: Canada
facility: CISSS de Chaudière-Appalaches, Hôpital Hotel-Dieu de Lévis /ID# 150361
state: Quebec
city: Montreal
country: Canada
facility: Recherche GCP Research /ID# 151822
state: Quebec
city: Montreal
country: Canada
facility: Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 167169
state: Quebec
city: Montréal
country: Canada
facility: Montreal General Hospital - McGill University Health Centre /ID# 170012
state: Quebec
city: Sherbrooke
country: Canada
facility: CIUSSS de l'Estrie - CHUS /ID# 150366
state: Quebec
city: Santiago
country: Chile
facility: Research Group /ID# 203176
state: Region Metropolitana De Santiago
city: Santiago
country: Chile
facility: M y F Estudios Clínicos /ID# 200107
state: Region Metropolitana Santiago
city: Viña del Mar
country: Chile
facility: Centro de Investigaciones Clínicas Viña del Mar /ID# 150212
state: Valparaíso
city: Concepción
country: Chile
facility: Hospital Guillermo Grant Benavente de Concepción /ID# 212424
city: Providencia
country: Chile
facility: CTR Estudios Clinicos /ID# 200110
city: Santiago
country: Chile
facility: Hospital Clinico Universidad De Los Andes /ID# 207422
city: Guangzhou
country: China
facility: The First Affiliated Hospital, Sun Yat-sen University /ID# 150455
state: Guangdong
city: Guangzhou
country: China
facility: The Sixth Affiliated Hosp Sun /ID# 150456
state: Guangdong
city: Shiyan
country: China
facility: Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216405
state: Hubei
city: Wuhan
country: China
facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 167088
state: Hubei
city: Wuhan
country: China
facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 167078
state: Hubei
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University /ID# 211750
state: Jiangxi
city: Changchun
country: China
facility: The First Hospital of Jilin University /ID# 209986
state: Jilin
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 150461
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Tenth People's Hospital /ID# 150460
state: Shanghai
city: Shanghai
country: China
facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 165815
state: Shanghai
city: Hangzhou
country: China
facility: The second Affiliated hospital of Zhejiang University school of Medicine /ID# 165807
state: Zhejiang
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 150454
state: Zhejiang
city: Changsha
country: China
facility: Xiangya Hospital Central South University /ID# 167229
city: Chengdu
country: China
facility: West China Hospital, Sichuan University /ID# 167040
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University /ID# 166920
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital /ID# 170604
city: Monteria
country: Colombia
facility: Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 207042
state: Cordoba
city: Bogota DC
country: Colombia
facility: Corporacion Hospitalaria Juan Cuidad Sede Denominada Hospital Universitario Mayo /ID# 151564
state: Cundinamarca
city: Medellin
country: Colombia
facility: Hospital Universitario de San /ID# 155387
city: Zagreb
country: Croatia
facility: Clinical Hospital Dubrava /ID# 150213
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Zagreb /ID# 150225
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Zagreb /ID# 150709
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Poliklinika Solmed /ID# 211483
state: Grad Zagreb
city: Osijek
country: Croatia
facility: Duplicate_Klinicki bolnicki centar Osijek /ID# 150216
state: Osjecko-baranjska Zupanija
city: Rijeka
country: Croatia
facility: Klinicki bolnicki centar Rijeka /ID# 150708
state: Primorsko-goranska Zupanija
city: Split
country: Croatia
facility: Klinicki bolnicki centar Split /ID# 213988
state: Splitsko-dalmatinska Zupanija
city: Zadar
country: Croatia
facility: Zadar General Hospital /ID# 150221
city: Hradec Kralove
country: Czechia
facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 150912
city: Olomouc
country: Czechia
facility: CTCenter MaVe s.r.o. /ID# 150904
city: Ostrava
country: Czechia
facility: ARTROSCAN s.r.o. /ID# 150401
city: Pardubice
country: Czechia
facility: Nemocnice Pardubickeho kraje, a.s. /ID# 213539
city: Praha
country: Czechia
facility: Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216221
city: Praha
country: Czechia
facility: Axon Clinical, s.r.o. /ID# 152479
city: Praha
country: Czechia
facility: ISCARE a.s. /ID# 209278
city: Kesklinna Linnaosa
country: Estonia
facility: East Tallinn Central Hospital /ID# 150417
state: Harjumaa
city: Mustamäe Linnaosa
country: Estonia
facility: North Estonia Medical Centre /ID# 160870
state: Harjumaa
city: Tartu Linn
country: Estonia
facility: Tartu University Hospital /ID# 150418
state: Tartumaa
city: Tallinn
country: Estonia
facility: West Tallinn Central Hospital /ID# 150419
city: Tampere
country: Finland
facility: Tampere University Hospital /ID# 150114
state: Pirkanmaa
city: Helsinki
country: Finland
facility: Duplicate_Helsinki Univ Central Hospital /ID# 150407
city: Jyvaskyla
country: Finland
facility: Keski-Suomen Sairaala Nova /ID# 155666
city: Mikkeli
country: Finland
facility: Laakarikeskus Ikioma /ID# 150121
city: Turku
country: Finland
facility: Turku University Hospital /ID# 168301
city: Nice
country: France
facility: Chu de Nice-Hopital L'Archet Ii /Id# 152606
state: Alpes-Maritimes
city: Pierre Benite CEDEX
country: France
facility: HCL - Hôpital Lyon Sud /ID# 152539
state: Auvergne-Rhone-Alpes
city: Marseille
country: France
facility: CHU Hopital Nord /ID# 163508
state: Bouches-du-Rhone
city: Lille
country: France
facility: CHRU Lille - Hopital Claude Huriez /ID# 152607
state: Hauts-de-France
city: Montpellier Cedex 5
country: France
facility: CHU Montpellier - Hôpital Saint Eloi /ID# 200006
state: Herault
city: Amiens CEDEX 1
country: France
facility: CHU Amiens-Picardie Site Sud /ID# 163456
state: Somme
city: La Roche Sur Yon
country: France
facility: CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 154452
city: SAINT-ETIENNE Cedex 1
country: France
facility: CHU de Saint-Etienne, Hopital Nord /ID# 154453
city: Mannheim
country: Germany
facility: Universitatsklinikum Mannheim /ID# 150173
state: Baden-Wuerttemberg
city: Tubingen
country: Germany
facility: Universitaetsklinimum Tuebingen /ID# 150767
state: Baden-Wuerttemberg
city: Munster
country: Germany
facility: Universitatsklinikum Munster /ID# 150158
state: Niedersachsen
city: Herne
country: Germany
facility: Gastroenterologische Gemeinschaftspraxis Herne /ID# 214574
state: Nordrhein-Westfalen
city: Saarbrücken
country: Germany
facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215811
state: Saarland
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 161981
state: Schleswig-Holstein
city: Berlin
country: Germany
facility: MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 150766
city: Frankfurt am Main
country: Germany
facility: Agaplesion Markus Krankenhaus /ID# 161982
city: Muenster
country: Germany
facility: Medizinisches Versorgungszentrum Portal 10 /ID# 207135
city: Wiesbaden
country: Germany
facility: Praxis medicum /ID# 150166
city: Athens
country: Greece
facility: General Hospital of Athens Laiko /ID# 208669
state: Attiki
city: Athens
country: Greece
facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202100
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 150250
state: Kriti
city: Athens
country: Greece
facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 150309
city: Ioannina
country: Greece
facility: University General Hospital of Ioannina /ID# 164248
city: Thessaloniki
country: Greece
facility: Theageneio Anticancer Hospital /ID# 163896
city: Thessaloniki
country: Greece
facility: General Hospital of Thessaloniki Hippokrateio /ID# 209521
city: Szombathely
country: Hungary
facility: Markusovszky Egyetemi Oktatokorhaz /ID# 150313
state: Vas
city: Bekescsaba
country: Hungary
facility: Bekes Megyei Kozponti Korhaz /ID# 151572
city: Budapest
country: Hungary
facility: Semmelweis Egyetem /ID# 150312
city: Kecskemet
country: Hungary
facility: Meditres Kft. /ID# 151521
city: Sopron
country: Hungary
facility: Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 151523
city: Szekesfehervar
country: Hungary
facility: Mentahaz Maganorvosi Kozpont /ID# 205884
city: Beaumont
country: Ireland
facility: Beaumont Hospital /ID# 150321
state: Dublin
city: Dublin 8
country: Ireland
facility: St James Hospital /ID# 150320
state: Dublin
city: Elm Park
country: Ireland
facility: St Vincent's University Hospital /ID# 150318
state: Dublin
city: Cork
country: Ireland
facility: Mercy University Hospital /ID# 151529
city: Galway
country: Ireland
facility: University Hospital Galway /ID# 150319
city: Be'er Sheva
country: Israel
facility: Soroka University Medical Center /ID# 156561
state: HaDarom
city: Haifa
country: Israel
facility: Rambam Health Care Campus /ID# 150325
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center /ID# 161677
city: Jerusalem
country: Israel
facility: Hadassah Medical Center-Hebrew University /ID# 165118
city: Rome
country: Italy
facility: Azienda Ospedaliera San Camillo Forlanini /ID# 151360
state: Lazio
city: Rho
country: Italy
facility: ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216610
state: Milano
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas /ID# 151361
state: Milano
city: Rome
country: Italy
facility: Fondazione PTV Policlinico Tor Vergata /ID# 150338
state: Roma
city: Rome
country: Italy
facility: Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 150333
state: Roma
city: Negrar
country: Italy
facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 201725
state: Verona
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 150337
city: Milano
country: Italy
facility: ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 150602
city: Milan
country: Italy
facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 150334
city: Palermo
country: Italy
facility: A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 150253
city: Nagakute-shi
country: Japan
facility: Aichi Medical University Hospital /ID# 151993
state: Aichi
city: Nagoya shi
country: Japan
facility: Nagoya City University Hospital /ID# 151950
state: Aichi
city: Nagoyashi
country: Japan
facility: Nagoya University Hospital /ID# 152709
state: Aichi
city: Toyohashi-shi
country: Japan
facility: Toyohashi Municipal Hospital /ID# 171457
state: Aichi
city: Toyota-shi
country: Japan
facility: Ieda Hospital /ID# 157781
state: Aichi
city: Hirosaki-shi
country: Japan
facility: Hirosaki National Hospital /ID# 152763
state: Aomori
city: Abiko-shi
country: Japan
facility: Tokatsu Tsujinaka Hospital /ID# 214962
state: Chiba
city: Kashiwa-shi
country: Japan
facility: Tsujinaka Hospital Kashiwanoha /ID# 209130
state: Chiba
city: Sakura-shi
country: Japan
facility: Toho University Sakura Medical Center /ID# 151936
state: Chiba
city: Urayasu-shi
country: Japan
facility: Juntendo University Urayasu Hospital /ID# 208781
state: Chiba
city: Fukui-shi
country: Japan
facility: Fukui Prefectural Hospital /ID# 210448
state: Fukui
city: Chikushino-shi
country: Japan
facility: Fukuoka University Chikushi Hospital /ID# 152628
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Saiseikai Fukuoka Genaral Hospital /ID# 209479
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Kyushu University Hospital /ID# 152526
state: Fukuoka
city: Kitakyushu
country: Japan
facility: Kitakyushu Municipal Med Ctr /ID# 152588
state: Fukuoka
city: Kurume-shi
country: Japan
facility: Kurume University Hospital /ID# 151976
state: Fukuoka
city: Ogaki-shi
country: Japan
facility: Ogaki Municipal Hospital /ID# 208225
state: Gifu
city: Fukuyama-shi
country: Japan
facility: NHO Fukuyama Medical Center /ID# 206293
state: Hiroshima
city: Hiroshima-shi
country: Japan
facility: Hiroshima University Hospital /ID# 151951
state: Hiroshima
city: Asahikawa-shi
country: Japan
facility: Asahikawa Medical University Hospital /ID# 170289
state: Hokkaido
city: Obihiro-shi
country: Japan
facility: Obihiro kosei Hospital /ID# 210412
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Tokushukai Hospital /ID# 209397
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 151506
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Medical University Hospital /ID# 206492
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Higashi Tokushukai Hospital /ID# 208487
state: Hokkaido
city: Kobe-shi
country: Japan
facility: Aoyama Clinic /ID# 152049
state: Hyogo
city: Nishinomiya-shi
country: Japan
facility: Hyogo College of Medicine College Hospital /Id# 152434
state: Hyogo
city: Higashi Ibaraki-gun
country: Japan
facility: National Hospital Organization Mito Medical Center /ID# 152631
state: Ibaraki
city: Kanazawa-shi
country: Japan
facility: Kanazawa University Hospital /ID# 205099
state: Ishikawa
city: Morioka-shi
country: Japan
facility: Iwate Medical University Uchimaru Medical Center /ID# 203411
state: Iwate
city: Kagoshima-shi
country: Japan
facility: Imamura General Hospital /ID# 227134
state: Kagoshima
city: Kagoshima-shi
country: Japan
facility: Idzuro Imamura Hospital /ID# 206024
state: Kagoshima
city: Kagoshima-shi
country: Japan
facility: Sameshima Hospital /ID# 206672
state: Kagoshima
city: Kawasaki-shi
country: Japan
facility: St. Marianna University School of Medicine Hospital /ID# 208654
state: Kanagawa
city: Yokohama shi
country: Japan
facility: Yokohama City University Medical Center /ID# 169899
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Showa University Fujigaoka Hospital /ID# 208222
state: Kanagawa
city: Kyoto-shi
country: Japan
facility: Japanese Red Cross Kyoto Daiichi Hosital /ID# 152359
state: Kyoto
city: Kyoto-shi
country: Japan
facility: Kyoto University Hospital /ID# 211758
state: Kyoto
city: Tsu-shi
country: Japan
facility: Mie University Hospital /ID# 205362
state: Mie
city: Yokkaichi-shi
country: Japan
facility: Yokkaichi Hazu Medical Center /ID# 214347
state: Mie
city: Sendai-shi
country: Japan
facility: National Hospital Organization Sendai Medical Center /ID# 209527
state: Miyagi
city: Omura-shi
country: Japan
facility: NHO Nagasaki Medical Center /ID# 209531
state: Nagasaki
city: Yamatotakada-shi
country: Japan
facility: Kenseikai Dongo Hospital /ID# 208100
state: Nara
city: Niigata-shi
country: Japan
facility: Saiseikai Niigata Hospital /ID# 209916
state: Niigata
city: Niigata-shi
country: Japan
facility: Niigata University Medical & Dental Hospital /ID# 218048
state: Niigata
city: Oita-shi
country: Japan
facility: Ishida Clinic of IBD and Gastroenterology /ID# 210117
state: Oita
city: Kurashiki-shi
country: Japan
facility: Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 157821
state: Okayama
city: Okayama-shi
country: Japan
facility: Okayama University Hospital /ID# 217923
state: Okayama
city: Osaka-shi
country: Japan
facility: Kinshukai Infusion Clinic /ID# 207864
state: Osaka
city: Osaka-shi
country: Japan
facility: Kitano Hospital /ID# 210395
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka City General Hospital /ID# 152704
state: Osaka
city: Osaka-shi
country: Japan
facility: Japanese Red Cross Osaka Hospital /ID# 209476
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka City University Hospital /ID# 152682
state: Osaka
city: Toyonaka-shi
country: Japan
facility: Toyonaka Municipal Hospital /ID# 217079
state: Osaka
city: Saga-shi
country: Japan
facility: Saga University Hospital /ID# 209268
state: Saga
city: Kawagoe-shi
country: Japan
facility: Saitama Medical Center /ID# 152031
state: Saitama
city: Saitama-shi
country: Japan
facility: Tokitokai Tokito clinic /ID# 152677
state: Saitama
city: Higashi-ohmi-shi
country: Japan
facility: National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210709
state: Shiga
city: Izumo-shi
country: Japan
facility: Shimane University Hospital /ID# 208899
state: Shimane
city: Hamamatsu-shi
country: Japan
facility: Hamamatsu University Hospital /ID# 205708
state: Shizuoka
city: Sunto-gun
country: Japan
facility: NHO Shizuoka Medical Center /ID# 163572
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Tokyo Medical And Dental University Hospital /ID# 152016
state: Tokyo
city: Chuo-ku
country: Japan
facility: St.Luke's International Hospital /ID# 208074
state: Tokyo
city: Hachioji-shi
country: Japan
facility: Tokai University Hachioji Hospital /ID# 152587
state: Tokyo
city: Itabashi-ku
country: Japan
facility: Teikyo University Hospital /ID# 208897
state: Tokyo
city: Minato-ku
country: Japan
facility: Kitasato University Kitasato Institute Hospital /ID# 152686
state: Tokyo
city: Mitaka-shi
country: Japan
facility: Kyorin University Hospital /ID# 153194
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Center Hospital of the National Center for Global Health and Medicine /ID# 209267
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Women's Medical University Hospital /ID# 205977
state: Tokyo
city: Yamagata-shi
country: Japan
facility: Yamagata University Hospital /ID# 171454
state: Yamagata
city: Shunan-shi
country: Japan
facility: Tokuyama Central Hospital /ID# 216993
state: Yamaguchi
city: Kofu-shi
country: Japan
facility: Yamanashi Prefectural Central Hospital /ID# 151908
state: Yamanashi
city: Takatsuki-shi
country: Japan
facility: Shoyukai Fujita Gastroenterological Hospital /ID# 216492
city: Guri
country: Korea, Republic of
facility: Hayang University GuriHospital /ID# 150344
state: Gyeonggido
city: Seongnam si
country: Korea, Republic of
facility: CHA University Bundang Medical Center /ID# 159479
state: Gyeonggido
city: Suwon
country: Korea, Republic of
facility: The Catholic University of Korea, ST. Vincent's Hospital /ID# 150347
state: Gyeonggido
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital /ID# 150348
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Yonsei University Health System Severance Hospital /ID# 159478
state: Seoul Teugbyeolsi
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital /ID# 159480
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital /ID# 159481
city: Daegu
country: Korea, Republic of
facility: Yeungnam University Medical Center /ID# 150345
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center /ID# 150900
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center /ID# 150346
city: Riga
country: Latvia
facility: Pauls Stradins Clinical University Hospital /ID# 151409
city: Riga
country: Latvia
facility: Riga East Clinical University Hospital /ID# 150354
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 150357
city: Klaipeda
country: Lithuania
facility: Klaipeda Seamens Hospital /ID# 154319
city: Klaipeda
country: Lithuania
facility: Klaipeda University Hospital /ID# 158862
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital /ID# 154318
city: Alor Setar
country: Malaysia
facility: Hospital Sultanah Bahiyah /ID# 151687
state: Kedah
city: Kuala Lumpur
country: Malaysia
facility: Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 151689
state: Selangor
city: Ampang
country: Malaysia
facility: Hospital Ampang /ID# 151298
city: Kuala Lumpur
country: Malaysia
facility: Uni Malaya MC /ID# 150359
city: Leon
country: Mexico
facility: Morales Vargas Centro de Investigacion S.C. /ID# 211325
state: Guanajuato
city: Guadalajara
country: Mexico
facility: Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 150710
state: Jalisco
city: Monterrey
country: Mexico
facility: Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 150256
state: Nuevo Leon
city: Nijmegen
country: Netherlands
facility: Radboud Universitair Medisch Centrum /ID# 151700
state: Gelderland
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum /ID# 150308
state: Zuid-Holland
city: Amsterdam
country: Netherlands
facility: Academisch Medisch Centrum /ID# 150647
city: Leiden
country: Netherlands
facility: Leids Universitair Medisch Centrum /ID# 152624
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum Utrecht /ID# 152775
city: Nordbyhagen
country: Norway
facility: Akershus universitetssykehus /ID# 150317
state: Akershus
city: Tromsø
country: Norway
facility: Universitetssykehuset Nord-Norge /ID# 152835
state: Troms
city: Torun
country: Poland
facility: Gastromed /Id# 216197
state: Kujawsko-pomorskie
city: Warszawa
country: Poland
facility: Centrum Zdrowia MDM /ID# 150351
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 150580
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centrum Medyczne Reuma Park /ID# 150349
state: Mazowieckie
city: Warszawa
country: Poland
facility: NZOZ Vivamed /ID# 216742
state: Mazowieckie
city: Warszawa
country: Poland
facility: Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215732
state: Mazowieckie
city: Sopot
country: Poland
facility: Endoskopia Sp. z o.o. /ID# 150765
state: Pomorskie
city: Guimaraes
country: Portugal
facility: Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 151607
state: Braga
city: Santa Maria Da Feira
country: Portugal
facility: Centro Hospitalar de Entre Douro e Vouga /ID# 152335
state: Porto
city: Ponte de Lima
country: Portugal
facility: Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 151609
state: Viana Do Castelo
city: Almada
country: Portugal
facility: Hospital Garcia de Orta, EPE /ID# 151613
city: Braga
country: Portugal
facility: CCA Braga - Hospital de Braga /ID# 151608
city: Lisboa
country: Portugal
facility: Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 151611
city: Lisboa
country: Portugal
facility: Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 151606
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 151610
city: San Juan
country: Puerto Rico
facility: School of Medicine University of Puerto Rico-Medical Science Campus /ID# 150358
city: Kaliningrad
country: Russian Federation
facility: Immanuel Kant Baltic Federal University /ID# 200719
state: Kaliningradskaya Oblast
city: St. Petersburg
country: Russian Federation
facility: NW State Medical Univ na Mechn /ID# 169322
state: Leningradskaya Oblast
city: Perm
country: Russian Federation
facility: Perm Clinical Center of the Federal Medical and Biological Agency /ID# 150386
state: Permskiy Kray
city: Samara
country: Russian Federation
facility: Medical Company Hepatolog /ID# 200197
state: Samarskaya Oblast
city: Pyatigorsk
country: Russian Federation
facility: LLC Novaya Klinika /ID# 208107
state: Stavropol Skiy Kray
city: Kazan
country: Russian Federation
facility: Kazan State Medical University /ID# 166042
state: Tatarstan, Respublika
city: Moscow
country: Russian Federation
facility: Olla-Med Clinic /ID# 215332
city: Moscow
country: Russian Federation
facility: City Clinical Hospital #24 /ID# 150395
city: Petrozavodsk
country: Russian Federation
facility: Republican hospital named after V.A. Baranov /ID# 206506
city: Pushkin
country: Russian Federation
facility: Euromedservice /ID# 203800
city: Stavropol
country: Russian Federation
facility: Duplicate_Stavropol State Medical Univ /ID# 150387
city: Belgrade
country: Serbia
facility: Clinical Hosp Center Zvezdara /ID# 150427
state: Beograd
city: Belgrade
country: Serbia
facility: Military Medical Academy /ID# 150429
state: Beograd
city: Belgrade
country: Serbia
facility: University Clinical Center Serbia /ID# 150428
state: Beograd
city: Belgrade
country: Serbia
facility: Clin Hosp Ctr Bezanijska Kosa /ID# 150426
state: Beograd
city: NIS
country: Serbia
facility: University Clinical Center of Nis /ID# 151903
state: Nisavski Okrug
city: Kragujevac
country: Serbia
facility: University Clinical Center Kragujevac /ID# 150430
state: Sumadijski Okrug
city: Novi Sad
country: Serbia
facility: Clinical Center Vojvodina /ID# 150764
state: Vojvodina
city: Leskovac
country: Serbia
facility: General Hospital Leskovac /ID# 217880
city: Singapore
country: Singapore
facility: National University Hospital /ID# 150453
city: Singapore
country: Singapore
facility: Gleneagles Medical Centre /ID# 206018
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital /ID# 150443
city: Banska Bystrica
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 150868
city: Bratislava
country: Slovakia
facility: Medak s.r.o. /ID# 150480
city: Ilava
country: Slovakia
facility: Slovak Research Center Team Me /ID# 150257
city: Kosice
country: Slovakia
facility: B+B MED, s.r.o. /ID# 150471
city: Nove Zamky
country: Slovakia
facility: Fakultna nemocnica s poliklinikou Nove Zamky /ID# 211370
city: Presov
country: Slovakia
facility: GASTRO I., s.r.o. /ID# 150472
city: Boksburg North
country: South Africa
facility: MD Search /ID# 167293
state: Gauteng
city: Johannesburg
country: South Africa
facility: Clinresco Centers /ID# 163622
state: Gauteng
city: Johannesburg
country: South Africa
facility: Lenasia Clinical Trial Centre /ID# 214344
state: Gauteng
city: Johannesburg
country: South Africa
facility: Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 150785
state: Gauteng
city: Johannesburg
country: South Africa
facility: Wits Clinical Research Site /ID# 150496
state: Gauteng
city: CAPE TOWN Milnerton
country: South Africa
facility: Spoke Research Inc /ID# 162202
state: Western Cape
city: Cape Town
country: South Africa
facility: Kingsbury Hospital /ID# 150497
state: Western Cape
city: Cape Town
country: South Africa
facility: Private Practice Dr MN Rajabally /ID# 155144
state: Western Cape
city: Santiago de Compostela
country: Spain
facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 151065
state: A Coruna
city: Santander
country: Spain
facility: Hospital Unversitario Marques de Valdecilla /ID# 216620
state: Cantabria
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Universitario Dr. Negrin /ID# 203937
state: Las Palmas
city: A Coruna
country: Spain
facility: Hospital Universitario A Coruna - CHUAC /ID# 203911
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona /ID# 150612
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia /ID# 151066
city: Madrid
country: Spain
facility: Hospital Universitario Ramon y Cajal /ID# 151067
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 214539
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca /ID# 150509
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe /ID# 150611
city: Gothenburg
country: Sweden
facility: Sahlgrenska University Hospital /ID# 151496
state: Vastra Gotalands Lan
city: Basel
country: Switzerland
facility: Universitätsspital Basel /ID# 161731
state: Basel-Stadt
city: St. Gallen
country: Switzerland
facility: Kantonsspital St. Gallen /ID# 152599
state: Sankt Gallen
city: Zürich
country: Switzerland
facility: Universitätsspital Zürich /ID# 152591
state: Zuerich
city: Bern
country: Switzerland
facility: Inselspital, Universitätsspital Bern /ID# 152590
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 150575
city: Taichung City
country: Taiwan
facility: China Medical University Hospital /ID# 150571
city: Taichung
country: Taiwan
facility: Chung Shan Medical University Hospital /ID# 150573
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital /ID# 151749
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 150574
city: Taipei City
country: Taiwan
facility: Taipei Veterans General Hosp /ID# 151748
city: Melikgazi
country: Turkey
facility: Erciyes University Medical Fac /ID# 150129
state: Kayseri
city: Istanbul
country: Turkey
facility: Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 150125
city: Istanbul
country: Turkey
facility: Umraniye Training and Res Hosp /ID# 162659
city: Istanbul
country: Turkey
facility: Marmara University Medical Fac /ID# 213969
city: Mersin
country: Turkey
facility: Mersin University Medical /ID# 157849
city: Yenimahalle
country: Turkey
facility: Gazi Universitesi Tip Fakultes /ID# 150127
city: Vinnytsya
country: Ukraine
facility: Medical Center of the "Health /ID# 151274
state: Vinnytska Oblast
city: Dnipro
country: Ukraine
facility: Municipal Enterprise "I.I. Mechnikov Dnipropetrovsk Regional Clinical Hospital" /ID# 207723
city: Kharkiv
country: Ukraine
facility: CNCE of Kharkiv Regional Council Regional Clinical Hospital /ID# 206940
city: Kropyvnytskyi
country: Ukraine
facility: PE PMC Acinus, Medical and Diagnostic Center /ID# 217216
city: Kyiv
country: Ukraine
facility: Kyiv Municipal Clinical Hospital #18 /ID# 150372
city: Kyiv
country: Ukraine
facility: Medical Center CONSILIUM MEDICAL /ID# 217446
city: Kyiv
country: Ukraine
facility: CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 217372
city: Lviv
country: Ukraine
facility: Lviv Regional Clinical Hospital /ID# 150375
city: Odesa
country: Ukraine
facility: Municipal Non-Commercial Enterprise Odesa Regional Clinical Hospital of the Od /ID# 151275
city: Vinnytsia
country: Ukraine
facility: CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 216297
city: Exeter
country: United Kingdom
facility: Royal Devon and Exeter NHS Trust Hospital /ID# 150379
state: Devon
city: Basingstoke
country: United Kingdom
facility: Hampshire Hospitals NHS Foundation Trust /ID# 150380
state: Essex
city: London
country: United Kingdom
facility: Barts Health NHS Trust /ID# 150384
state: London, City Of
city: Glasgow
country: United Kingdom
facility: NHS Greater Glasgow and Clyde /ID# 163787
state: Scotland
city: Bath
country: United Kingdom
facility: Royal United Hospitals Bath /ID# 151532
city: Birmingham
country: United Kingdom
facility: University Hospitals Birmingham NHS Foundation Trust /ID# 150382
city: Huddersfield
country: United Kingdom
facility: Calderdale and Huddersfield NHS Foundation Trust /ID# 217658
city: Tooting
country: United Kingdom
facility: St George's University Hospitals NHS Foundation Trust /ID# 208374
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References:
citation: Danese S, Vermeire S, Zhou W, Pangan AL, Siffledeen J, Greenbloom S, Hebuterne X, D'Haens G, Nakase H, Panes J, Higgins PDR, Juillerat P, Lindsay JO, Loftus EV Jr, Sandborn WJ, Reinisch W, Chen MH, Sanchez Gonzalez Y, Huang B, Xie W, Liu J, Weinreich MA, Panaccione R. Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials. Lancet. 2022 Jun 4;399(10341):2113-2128. doi: 10.1016/S0140-6736(22)00581-5. Epub 2022 May 26.
citation: Sandborn WJ, Ghosh S, Panes J, Schreiber S, D'Haens G, Tanida S, Siffledeen J, Enejosa J, Zhou W, Othman AA, Huang B, Higgins PDR. Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis. Gastroenterology. 2020 Jun;158(8):2139-2149.e14. doi: 10.1053/j.gastro.2020.02.030. Epub 2020 Feb 22.