Clinical trial NCT04629482: Brain Activity by Magnetoencephalography for Children
Official title: The Brain Network Activity of Functional Tasks Performance by Magnetoencephalography for Children
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Brain Activity
Keywords: attention deficit hyperactivity disorder
networks
magnetoencephalography
developmental delay
children
Lead sponsor: Taipei Medical University
Sponsor class: OTHER
First posted: 2020-11-16
Enrollment: 24
Sex: ALL
Minimum age (years): 4
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children diagnosed with attention deficit hyperactivity disorder with developmental delays, aged 4 to 10; and age-sex matched children with typical development

Brief summary: Investigate the differences in activation of brain networks during performing functional tasks for children with attention deficit hyperactivity disorder with developmental delays and typical development

Detailed description: A total of 12 children with attention deficit hyperactivity disorder with developmental delays and12 children with typical development will be enrolled.

The following evaluations will be evaluated by the investigator who is blinded to the group's classification.

Working task-related functions, such as Beery-Buktenica Visual-Motor Integration, Sensory Profile, the Chinese version of Swanson, Nolan and Pelham version IV, and Chinese version of Wechsler Intelligence Scale for Children-IV)

Non-working memory-related functions, such as Pediatric Outcome Data Collection Instrument (PODCI), Child Health Questionnaire- Parent Form (CHQ-PF 28), Pediatric Quality of Life Inventory (PedsQL), and physical function (10 meters normal and fast walking, stair ascent, stair descent, and 5 times chair rising and timed up and go test)

All participants will be investigated by magnetoencephalography and eye-tracking system to identify the difference of brain network activation during resting and performing tasks and between-group differences.

Brain magnetic resonance image study will be performed for matching of brain localization.

Eligibility criteria: Inclusion Criteria:

* children with attention deficit hyperactivity disorder with development delays
* intelligence quotient 70 or greater

Exclusion Criteria:

* age less than 4 or greater than 10 of children
* intelligence quotient less than 70

Primary outcomes:
measure: Brain network activity by magnetoencephalograph
timeFrame: measure simultaneous brain activity by different types of music through study completion, up to 6 minutes
measure: Brain network activity by magnetoencephalography
timeFrame: measure simultaneous brain activity by different types of videos through study completion, up to 10.5 minutes
measure: Brain network activity by magnetoencephalography
timeFrame: measure simultaneous brain activity by different types of interactive cognitive stimulation through study completion, up to 5 minutes
Secondary outcomes:
Other outcomes:
measure: Beery-Buktenica Visual-Motor Integration
timeFrame: before magnetoencephalography examination
measure: Sensory Profile Questionnaire
timeFrame: before magnetoencephalography examination
measure: Swanson, Nolan and Pelham
timeFrame: before magnetoencephalography examination
measure: Wechsler Intelligence Scale for Children
timeFrame: before magnetoencephalography examination
measure: Pediatric Outcome Data Collection Instrument
timeFrame: before magnetoencephalography examination
measure: Child Health Questionnaire- Parent Form
timeFrame: before magnetoencephalography examination
measure: Pediatric Quality of Life Inventory
timeFrame: before magnetoencephalography examination
measure: 10 meters walking speed
timeFrame: before magnetoencephalography examination
measure: stairs climbing time
timeFrame: before magnetoencephalography examination
measure: chair-rising time
timeFrame: before magnetoencephalography examination
measure: timed up and go
timeFrame: before magnetoencephalography examination
Locations:
city: Taipei
country: Taiwan
facility: Shin Kong Wu Ho-Su Memorial Hospital
Study officials:
affiliation: Shin Kong Wu Ho-Su Memorial Hospital
name: Ru-Lan Ru-Lan, MD
role: PRINCIPAL_INVESTIGATOR
References: