Clinical trial NCT06957158: The Effect of Serum Calcium Levels on Postoperative Pain: A Prospective Observational Study
Official title: The Effect of Serum Calcium Levels on Postoperative Pain in Patients Undergoing Abdominal Surgery: A Prospective Observational Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Postoperative Pain
Keywords: Serum calcium levels
Postoperative pain
Ionized calcium levels
Lead sponsor: The Second Affiliated Hospital of Chongqing Medical University
Sponsor class: OTHER
First posted: 2025-05-04
Enrollment: 350
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who underwent elective abdominal surgery under general anesthesia

Brief summary: This is a prospective observational study. To investigate the effect of serum calcium levels on postoperative pain in patients undergoing abdominal surgery, and to determine whether changes in serum calcium levels are a risk factor for postoperative pain.

Detailed description: This study aimed to measure the total serum calcium and ionized calcium levels both before and after surgery. Additionally, NRS scores were recorded at different time points.

Eligibility criteria: Inclusion Criteria:

* Aged 18-70 years old
* American Society of Anesthesiologists Classification I-III
* Patients undergoing elective abdominal surgery under general anesthesia
* Patients participate voluntarily and sign an informed consent form

Exclusion Criteria:

* Patients with a history of severe disease
* Patients with chronic preoperative pain and/or long-term analgesic use
* Patients with hearing disorders or verbal communication difficulties
* Patients with psychiatric disorders or cognitive dysfunction
* Patients requiring mechanical ventilation or ICU admission after surgery
* Patients with a history of substance or alcohol abuse Patients who could not cooperate with the study for any reason

Primary outcomes:
measure: The incidence of pain NRS score ≥6 within 48 hours after surgery
timeFrame: From the end of the surgery to 48 hours after surgery
Secondary outcomes:
measure: The maximum incisional pain score at 0-12h postoperatively
timeFrame: From the end of the surgery to 12 hours after surgery
measure: The maximum incisional pain score at 12-24h postoperatively
timeFrame: From 12hours to 24 hours after surgery
measure: The maximum incisional pain score at 24-48h postoperatively
timeFrame: From 24 hours to 48 hours after surgery
measure: The maximum visceral pain score at 0-12h postoperatively
timeFrame: From the end of the surgery to 12 hours after surgery
measure: The maximum visceral pain score at 12-24h postoperatively
timeFrame: From 12 hours to 24 hours after surgery
measure: The maximum visceral pain score at 24-48h postoperatively
timeFrame: From 24 hours to 48 hours after surgery
measure: Whether additional analgesia was administered within 48 hours after surgery
timeFrame: From the end of the surgery to 48 hours after surgery
measure: Patient-controlled intravenous analgesia opioid consumption
timeFrame: From the end of the surgery to 24 hours and 48 hours after surgery
Other outcomes:
Locations:
city: Chongqing
country: China
facility: The Second Affiliated Hospital of Chongqing Medical University
state: Chongqing
Study officials:
References: