Clinical trial NCT01111240: Efficacy and Safety of Humira® in Patients With Psoriatic Arthritis in Normal Medical Practice
Official title: A Long Term Documentation to Demonstrate Long Term Efficacy and Safety of Humira® in Patients With Psoriatic Arthritis Under Conditions of Daily Practice
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Psoriatic Arthritis
Keywords: Humira
Long-term safety and effectiveness
Psoriatic Arthritis
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2010-04-27
Enrollment: 4635
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Clinical routine patients with psoriatic arthritis

Brief summary: This study is a documentation of effectiveness and safety of Humira in patients with psoriatic arthritis.

Detailed description: Psoriatic Arthritis participants receiving adalimumab are evaluated in a prospective, non-interventional study (NIS) for 2 years. Patients receive adalimumab 40 mg every other week (eow), per its label. Efficacy and safety parameters are measured routinely at baseline and after 3, 6, 9, 12, 18 and 24 months.

Eligibility criteria: Inclusion:

* 18 years of age or older (younger patients may be enrolled at the discretion of physician)
* Diagnosis of Psoriatic Arthritis (or any indication at the discretion of physician) and initiating adalimumab therapy
* Signed/dated Informed Consent

Exclusion:

-None

Primary outcomes:
measure: Mean Change From Baseline in Disease Activity Score (DAS)28
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
measure: Mean Tender Joint Count (TJC) Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Mean Swollen Joint Count (SJC) Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Mean Percent Body Surface Area (BSA) Affected by Psoriasis Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Mean Target Lesion Score (TLS) Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Number of Participants With Adverse Events (AEs)
timeFrame: Baseline up to 24 months
Secondary outcomes:
measure: Number of Participants by Severity of Enthesitis Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Number of Participants by Severity of Dactylitis Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Number of Participants by Severity of Nail Psoriasis Levels Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Mean Erythrocyte Sedimentation Rate (ESR) Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Mean C-Reactive Protein (CRP) Levels Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Patients Global Assessment of Disease Activity Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Participants Assessment of Fatigue Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Participants Assessment of Pain Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Mean Funktionsfragebogen Hannover (FFbH) Questionnaire Scores Over Time
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Percentage of Participants With Impairment in Daily Activities During the Last 4 Weeks of Each Visit
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Mean Number of Days Missed From Work Due to Psoriatic Arthritis
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Percentage of Participants With In-Patient Hospitalization
timeFrame: Baseline, and Months 3, 6, 9, 12, 18, and 24
measure: Percentage of Participants on Concomitant Systemic Rheumatic and Pain Relief Medication
timeFrame: Baseline, and Months 6 and 24
Other outcomes:
Locations:
city: Aachen
country: Germany
facility: Site Reference ID/Investigator# 35035
city: Aachen
country: Germany
facility: Site Reference ID/Investigator# 64288
city: Ahlen
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city: Ahrensburg
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city: Altenburg
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city: Altenholz
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city: Amberg
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city: Annaberg-Buchholz
country: Germany
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city: Arnstadt
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city: Artern
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city: Augsburg
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city: Bad Abbach
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city: Bad Aibling
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city: Bad Bramstedt
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city: Bad Endbach
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country: Germany
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country: Germany
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country: Germany
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country: Germany
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country: Germany
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country: Germany
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city: Heidelberg
country: Germany
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country: Germany
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city: Heidelberg
country: Germany
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city: Heidelberg
country: Germany
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city: Heilbad Heiligenstadt
country: Germany
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city: Heilbad Heiligenstadt
country: Germany
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city: Herne
country: Germany
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city: Herrsching
country: Germany
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city: Herten
country: Germany
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city: Hildburghausen
country: Germany
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city: Hilden
country: Germany
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city: Hildesheim
country: Germany
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city: Hofheim
country: Germany
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city: Hof
country: Germany
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city: Hohen Neuendorf
country: Germany
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city: Hohenfelde
country: Germany
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city: Holzkirchen
country: Germany
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city: Homburg
country: Germany
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city: Homburg
country: Germany
facility: Site Reference ID/Investigator# 91085
city: Hoyerswerda
country: Germany
facility: Site Reference ID/Investigator# 53109
city: Immenstadt
country: Germany
facility: Site Reference ID/Investigator# 33857
city: Ingoldstadt
country: Germany
facility: Site Reference ID/Investigator# 98538
city: Ingolstadt
country: Germany
facility: Site Reference ID/Investigator# 33934
city: Ingolstadt
country: Germany
facility: Site Reference ID/Investigator# 53111
city: Jena
country: Germany
facility: Site Reference ID/Investigator# 53053
city: Jena
country: Germany
facility: Site Reference ID/Investigator# 53055
city: Jena
country: Germany
facility: Site Reference ID/Investigator# 5305
city: Juelich
country: Germany
facility: Site Reference ID/Investigator# 33941
city: Kahla
country: Germany
facility: Site Reference ID/Investigator# 33945
city: Kahla
country: Germany
facility: Site Reference ID/Investigator# 35123
city: Kaiserslautern
country: Germany
facility: Site Reference ID/Investigator# 33949
city: Kamenz
country: Germany
facility: Site Reference ID/Investigator# 52992
city: Karlsruhe
country: Germany
facility: Site Reference ID/Investigator# 33960
city: Karlstadt
country: Germany
facility: Site Reference ID/Investigator# 35483
city: Kassel
country: Germany
facility: Site Reference ID/Investigator# 53192
city: Kassel
country: Germany
facility: Site Reference ID/Investigator# 33963
city: Katzhuette
country: Germany
facility: Site Reference ID/Investigator# 33967
city: Kiel
country: Germany
facility: Site Reference ID/Investigator# 53229
city: Kleinmachnow
country: Germany
facility: Site Reference ID/Investigator# 72859
city: Koblenz
country: Germany
facility: Site Reference ID/Investigator# 53233
city: Koenigs Wusterhausen
country: Germany
facility: Site Reference ID/Investigator# 34001
city: Krefeld
country: Germany
facility: Site Reference ID/Investigator# 91076
city: Krefeld
country: Germany
facility: Site Reference ID/Investigator# 91093
city: Krefeld
country: Germany
facility: Site Reference ID/Investigator# 53108
city: Kressbronn
country: Germany
facility: Site Reference ID/Investigator# 34007
city: Kronach
country: Germany
facility: Site Reference ID/Investigator# 34083
city: Kyritz
country: Germany
facility: Site Reference ID/Investigator# 53101
city: Lahr
country: Germany
facility: Site Reference ID/Investigator# 34004
city: Landau
country: Germany
facility: Site Reference ID/Investigator# 35244
city: Langenfeld
country: Germany
facility: Site Reference ID/Investigator# 64290
city: Leinefelde
country: Germany
facility: Site Reference ID/Investigator# 53245
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 53115
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 53087
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 34105
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 34108
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 53197
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 53052
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 53211
city: Leverkusen
country: Germany
facility: Site Reference ID/Investigator# 53088
city: Lichtenstein
country: Germany
facility: Site Reference ID/Investigator# 34122
city: Lingen
country: Germany
facility: Site Reference ID/Investigator# 53180
city: Lippstadt
country: Germany
facility: Site Reference ID/Investigator# 35253
city: Loebau
country: Germany
facility: Site Reference ID/Investigator# 96240
city: Ludwigsfelde
country: Germany
facility: Site Reference ID/Investigator# 35259
city: Ludwigshafen
country: Germany
facility: Site Reference ID/Investigator# 53195
city: Ludwigslust
country: Germany
facility: Site Reference ID/Investigator# 53249
city: Luebeck
country: Germany
facility: Site Reference ID/Investigator# 53110
city: Luebeck
country: Germany
facility: Site Reference ID/Investigator# 34135
city: Luedenscheid
country: Germany
facility: Site Reference ID/Investigator# 53074
city: Lueneburg
country: Germany
facility: Site Reference ID/Investigator# 96239
city: Lutherstadt Eisleben
country: Germany
facility: Site Reference ID/Investigator# 53000
city: Magdeburg
country: Germany
facility: Site Reference ID/Investigator# 34146
city: Magdeburg
country: Germany
facility: Site Reference ID/Investigator# 34149
city: Magdeburg
country: Germany
facility: Site Reference ID/Investigator# 91082
city: Magdeburg
country: Germany
facility: Site Reference ID/Investigator# 64292
city: Magdeburg
country: Germany
facility: Site Reference ID/Investigator# 68583
city: Magdeburg
country: Germany
facility: Site Reference ID/Investigator# 53230
city: Magdeburg
country: Germany
facility: Site Reference ID/Investigator# 64305
city: Mainz
country: Germany
facility: Site Reference ID/Investigator# 53075
city: Mainz
country: Germany
facility: Site Reference ID/Investigator# 68593
city: Mannheim
country: Germany
facility: Site Reference ID/Investigator# 34179
city: Marktredwitz
country: Germany
facility: Site Reference ID/Investigator# 34191
city: Marl
country: Germany
facility: Site Reference ID/Investigator# 34195
city: Meissen
country: Germany
facility: Site Reference ID/Investigator# 34199
city: Melsungen
country: Germany
facility: Site Reference ID/Investigator# 53269
city: Memmingen
country: Germany
facility: Site Reference ID/Investigator# 53078
city: Menz
country: Germany
facility: Site Reference ID/Investigator# 35284
city: Minden
country: Germany
facility: Site Reference ID/Investigator# 35286
city: Mittelherwigsdorf
country: Germany
facility: Site Reference ID/Investigator# 34207
city: Moenchengladbach
country: Germany
facility: Site Reference ID/Investigator# 34217
city: Moenchengladbach
country: Germany
facility: Site Reference ID/Investigator# 34212
city: Moenchengladbach
country: Germany
facility: Site Reference ID/Investigator# 53095
city: Moenchengladbach
country: Germany
facility: Site Reference ID/Investigator# 53261
city: Moenkeburg
country: Germany
facility: Site Reference ID/Investigator# 57883
city: Muehlhausen
country: Germany
facility: Site Reference ID/Investigator# 34223
city: Muelheim
country: Germany
facility: Site Reference ID/Investigator# 35291
city: Muelheim
country: Germany
facility: Site Reference ID/Investigator# 53235
city: Muellheim
country: Germany
facility: Site Reference ID/Investigator# 34228
city: Muenster
country: Germany
facility: Site Reference ID/Investigator# 53062
city: Muenster
country: Germany
facility: Site Reference ID/Investigator# 68587
city: Muenster
country: Germany
facility: Site Reference ID/Investigator# 34047
city: Muenster
country: Germany
facility: Site Reference ID/Investigator# 53093
city: Muenster
country: Germany
facility: Site Reference ID/Investigator# 91096
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 64282
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 34039
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 57892
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 64295
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 35294
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 34234
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 91080
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 34042
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 53270
city: Naila
country: Germany
facility: Site Reference ID/Investigator# 53246
city: Nastaetten
country: Germany
facility: Site Reference ID/Investigator# 53271
city: Naumburg
country: Germany
facility: Site Reference ID/Investigator# 35305
city: Naunhof
country: Germany
facility: Site Reference ID/Investigator# 34051
city: Neubrandenburg
country: Germany
facility: Site Reference ID/Investigator# 34060
city: Neuburg
country: Germany
facility: Site Reference ID/Investigator# 34063
city: Neunkirchen
country: Germany
facility: Site Reference ID/Investigator# 53220
city: Neuss
country: Germany
facility: Site Reference ID/Investigator# 35312
city: Neustadt
country: Germany
facility: Site Reference ID/Investigator# 34075
city: Niefern-Oeschelbronn
country: Germany
facility: Site Reference ID/Investigator# 34079
city: Nienburg
country: Germany
facility: Site Reference ID/Investigator# 34157
city: Nienburg
country: Germany
facility: Site Reference ID/Investigator# 57891
city: Nordhausen
country: Germany
facility: Site Reference ID/Investigator# 52997
city: Nordhausen
country: Germany
facility: Site Reference ID/Investigator# 52999
city: Nordhausen
country: Germany
facility: Site Reference ID/Investigator# 53277
city: Nuremberg
country: Germany
facility: Site Reference ID/Investigator# 53054
city: Nuremberg
country: Germany
facility: Site Reference ID/Investigator# 68588
city: Nuremberg
country: Germany
facility: Site Reference ID/Investigator# 53112
city: Oberhausen
country: Germany
facility: Site Reference ID/Investigator# 96244
city: Oelsnitz
country: Germany
facility: Site Reference ID/Investigator# 34172
city: Oelsnitz
country: Germany
facility: Site Reference ID/Investigator# 53104
city: Offenburg
country: Germany
facility: Site Reference ID/Investigator# 34175
city: Oldenburg
country: Germany
facility: Site Reference ID/Investigator# 33491
city: Oldenburg
country: Germany
facility: Site Reference ID/Investigator# 57886
city: Oschatz
country: Germany
facility: Site Reference ID/Investigator# 91067
city: Osnabrueck
country: Germany
facility: Site Reference ID/Investigator# 53207
city: Osnabrueck
country: Germany
facility: Site Reference ID/Investigator# 81600
city: Ostseebad Damp
country: Germany
facility: Site Reference ID/Investigator# 53228
city: Paderborn
country: Germany
facility: Site Reference ID/Investigator# 35334
city: Parchim
country: Germany
facility: Site Reference ID/Investigator# 33507
city: Passau
country: Germany
facility: Site Reference ID/Investigator# 35339
city: Peitz
country: Germany
facility: Site Reference ID/Investigator# 72858
city: Petershagen
country: Germany
facility: Site Reference ID/Investigator# 53096
city: Pinneberg
country: Germany
facility: Site Reference ID/Investigator# 53086
city: Pirna
country: Germany
facility: Site Reference ID/Investigator# 53232
city: Planegg
country: Germany
facility: Site Reference ID/Investigator# 33522
city: Plauen
country: Germany
facility: Site Reference ID/Investigator# 33527
city: Plochingen
country: Germany
facility: Site Reference ID/Investigator# 96278
city: Potsdam
country: Germany
facility: Site Reference ID/Investigator# 33469
city: Potsdam
country: Germany
facility: Site Reference ID/Investigator# 33465
city: Potsdam
country: Germany
facility: Site Reference ID/Investigator# 96236
city: Potsdam
country: Germany
facility: Site Reference ID/Investigator# 53281
city: Pruem
country: Germany
facility: Site Reference ID/Investigator# 33475
city: Puettlingen
country: Germany
facility: Site Reference ID/Investigator# 33478
city: Puettlingen
country: Germany
facility: Site Reference ID/Investigator# 53257
city: Puettlingen
country: Germany
facility: Site Reference ID/Investigator# 91120
city: Quedlinburg
country: Germany
facility: Site Reference ID/Investigator# 53094
city: Querfurt
country: Germany
facility: Site Reference ID/Investigator# 53265
city: Radebeul
country: Germany
facility: Site Reference ID/Investigator# 33483
city: Radebeul
country: Germany
facility: Site Reference ID/Investigator# 35346
city: Ratingen
country: Germany
facility: Site Reference ID/Investigator# 53280
city: Ratingen
country: Germany
facility: Site Reference ID/Investigator# 57888
city: Ratzeburg
country: Germany
facility: Site Reference ID/Investigator# 33487
city: Regensburg
country: Germany
facility: Site Reference ID/Investigator# 33889
city: Regensburg
country: Germany
facility: Site Reference ID/Investigator# 57912
city: Regensburg
country: Germany
facility: Site Reference ID/Investigator# 57911
city: Regensburg
country: Germany
facility: Site Reference ID/Investigator# 53264
city: Rendsburg
country: Germany
facility: Site Reference ID/Investigator# 33901
city: Ribnitz-Damgarten
country: Germany
facility: Site Reference ID/Investigator# 52991
city: Riesa
country: Germany
facility: Site Reference ID/Investigator# 53267
city: Riesa
country: Germany
facility: Site Reference ID/Investigator# 33910
city: Rinteln
country: Germany
facility: Site Reference ID/Investigator# 33913
city: Rostock
country: Germany
facility: Site Reference ID/Investigator# 33922
city: Rostock
country: Germany
facility: Site Reference ID/Investigator# 33926
city: Rothenburg
country: Germany
facility: Site Reference ID/Investigator# 33930
city: Rudolstadt
country: Germany
facility: Site Reference ID/Investigator# 53113
city: Ruedersdorf
country: Germany
facility: Site Reference ID/Investigator# 35361
city: Saarbruecken
country: Germany
facility: Site Reference ID/Investigator# 34015
city: Saarlouis
country: Germany
facility: Site Reference ID/Investigator# 91071
city: Salzwedel
country: Germany
facility: Site Reference ID/Investigator# 34022
city: Sande
country: Germany
facility: Site Reference ID/Investigator# 34026
city: Schleiz
country: Germany
facility: Site Reference ID/Investigator# 53208
city: Schlettau
country: Germany
facility: Site Reference ID/Investigator# 91074
city: Schneeberg
country: Germany
facility: Site Reference ID/Investigator# 33533
city: Schramberg
country: Germany
facility: Site Reference ID/Investigator# 33538
city: Schutterwald
country: Germany
facility: Site Reference ID/Investigator# 33541
city: Schwandorf
country: Germany
facility: Site Reference ID/Investigator# 35370
city: Schwandorf
country: Germany
facility: Site Reference ID/Investigator# 91072
city: Schwedt
country: Germany
facility: Site Reference ID/Investigator# 57905
city: Schweina
country: Germany
facility: Site Reference ID/Investigator# 72855
city: Schwerin
country: Germany
facility: Site Reference ID/Investigator# 33548
city: Schwerin
country: Germany
facility: Site Reference ID/Investigator# 35375
city: Schwerte
country: Germany
facility: Site Reference ID/Investigator# 33554
city: Seesen
country: Germany
facility: Site Reference ID/Investigator# 33558
city: Sinsheim
country: Germany
facility: Site Reference ID/Investigator# 33566
city: Soltau
country: Germany
facility: Site Reference ID/Investigator# 33571
city: Spelle
country: Germany
facility: Site Reference ID/Investigator# 53255
city: St. Martin
country: Germany
facility: Site Reference ID/Investigator# 35382
city: Stadtbergen
country: Germany
facility: Site Reference ID/Investigator# 33584
city: Stolberg
country: Germany
facility: Site Reference ID/Investigator# 98539
city: Storkow
country: Germany
facility: Site Reference ID/Investigator# 53218
city: Straubing
country: Germany
facility: Site Reference ID/Investigator# 53082
city: Stuttgart
country: Germany
facility: Site Reference ID/Investigator# 33603
city: Stuttgart
country: Germany
facility: Site Reference ID/Investigator# 33606
city: Stuttgart
country: Germany
facility: Site Reference ID/Investigator# 33610
city: Stuttgart
country: Germany
facility: Site Reference ID/Investigator# 33597
city: Suhl
country: Germany
facility: Site Reference ID/Investigator# 53210
city: Suhl
country: Germany
facility: Site Reference ID/Investigator# 53223
city: Suhl
country: Germany
facility: Site Reference ID/Investigator# 35388
city: Torgelow
country: Germany
facility: Site Reference ID/Investigator# 33624
city: Treuenbrietzen
country: Germany
facility: Site Reference ID/Investigator# 53077
city: Treuenbrietzen
country: Germany
facility: Site Reference ID/Investigator# 57906
city: Tuttlingen
country: Germany
facility: Site Reference ID/Investigator# 53200
city: Ueberlingen-Nussdorf
country: Germany
facility: Site Reference ID/Investigator# 57910
city: Ulm
country: Germany
facility: Site Reference ID/Investigator# 33640
city: Ulm
country: Germany
facility: Site Reference ID/Investigator# 33723
city: Unna
country: Germany
facility: Site Reference ID/Investigator# 81602
city: Varel
country: Germany
facility: Site Reference ID/Investigator# 96241
city: Verden
country: Germany
facility: Site Reference ID/Investigator# 98536
city: Viersen
country: Germany
facility: Site Reference ID/Investigator# 72860
city: Villingen-Schwenningen
country: Germany
facility: Site Reference ID/Investigator# 33736
city: Waltrop
country: Germany
facility: Site Reference ID/Investigator# 33741
city: Wasserburg
country: Germany
facility: Site Reference ID/Investigator# 72853
city: Weener
country: Germany
facility: Site Reference ID/Investigator# 33748
city: Welzow
country: Germany
facility: Site Reference ID/Investigator# 33851
city: Wiesbaden
country: Germany
facility: Site Reference ID/Investigator# 35407
city: Wiesbaden
country: Germany
facility: Site Reference ID/Investigator# 33764
city: Wiesbaden
country: Germany
facility: Site Reference ID/Investigator# 52989
city: Wilhelmshaven
country: Germany
facility: Site Reference ID/Investigator# 33771
city: Winsen
country: Germany
facility: Site Reference ID/Investigator# 53076
city: Wismar
country: Germany
facility: Site Reference ID/Investigator# 33775
city: Wittlich
country: Germany
facility: Site Reference ID/Investigator# 33779
city: Wittmund
country: Germany
facility: Site Reference ID/Investigator# 91095
city: Wolfenbuettel
country: Germany
facility: Site Reference ID/Investigator# 96235
city: Wuerzburg
country: Germany
facility: Site Reference ID/Investigator# 33717
city: Wuerzburg
country: Germany
facility: Site Reference ID/Investigator# 57903
city: Wuppertal
country: Germany
facility: Site Reference ID/Investigator# 91068
city: Wuppertal
country: Germany
facility: Site Reference ID/Investigator# 91069
city: Wuppertal
country: Germany
facility: Site Reference ID/Investigator# 35419
city: Wurzen
country: Germany
facility: Site Reference ID/Investigator# 57884
city: Zeitz
country: Germany
facility: Site Reference ID/Investigator# 53064
city: Zerbst
country: Germany
facility: Site Reference ID/Investigator# 33863
city: Zeven
country: Germany
facility: Site Reference ID/Investigator# 33866
city: Zschopau
country: Germany
facility: Site Reference ID/Investigator# 64299
city: Zwickau
country: Germany
facility: Site Reference ID/Investigator# 52996
city: Zwickau
country: Germany
facility: Site Reference ID/Investigator# 33875
city: Zwickau
country: Germany
facility: Site Reference ID/Investigator# 52993
city: Zwickau
country: Germany
facility: Site Reference ID/Investigator# 53056
city: Zwickau
country: Germany
facility: Site Reference ID/Investigator# 53102
city: Zwickau
country: Germany
facility: Site Reference ID/Investigator# 52994
city: Zwickau
country: Germany
facility: Site Reference ID/Investigator# 53226
city: Zwickau
country: Germany
facility: Site Reference ID/Investigator# 53260
city: Zwiesel
country: Germany
facility: Site Reference ID/Investigator# 33879
Study officials:
affiliation: Abbvie Deutschland GmbH & Co. KG, Medical Department
name: Bianca Wittig, MD
role: STUDY_DIRECTOR
References:
citation: Behrens F, Koehm M, Schwaneck EC, Schmalzing M, Wittig BM, Gnann H, Greger G, Tony HP, Burkhardt H. Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis. Scand J Rheumatol. 2019 Sep;48(5):375-382. doi: 10.1080/03009742.2019.1600717. Epub 2019 Jul 16.
citation: Behrens F, Koehm M, Schwaneck EC, Schmalzing M, Gnann H, Greger G, Tony HP, Burkhardt H. Minimal disease activity is a stable measure of therapeutic response in psoriatic arthritis patients receiving treatment with adalimumab. Rheumatology (Oxford). 2018 Nov 1;57(11):1938-1946. doi: 10.1093/rheumatology/key203.
citation: Behrens F, Koehm M, Thaci D, Gnann H, Greger G, Maria Wittig B, Burkhardt H. Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis. Rheumatology (Oxford). 2016 Oct;55(10):1791-5. doi: 10.1093/rheumatology/kew229. Epub 2016 Jun 21.
citation: Behrens F, Koehm M, Arndt U, Wittig BM, Greger G, Thaci D, Scharbatke E, Tony HP, Burkhardt H. Does Concomitant Methotrexate with Adalimumab Influence Treatment Outcomes in Patients with Psoriatic Arthritis? Data from a Large Observational Study. J Rheumatol. 2016 Mar;43(3):632-9. doi: 10.3899/jrheum.141596. Epub 2015 Dec 15.