louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03720587: The Experiences of Patients With Greater Trochanteric Pain Syndrome.
Official title: The Experiences of Patients With Greater Trochanteric Pain Syndrome.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Greater Trochanteric Pain Syndrome
Keywords: GTPS
Gluteal tendinopathy
Lateral hip pain
Trochanteric bursitis
Lead sponsor: The Royal Orthopaedic Hospital NHS Trust
Sponsor class: OTHER
First posted: 2018-10-25
Enrollment: 10
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study participants will be identified from Orthopaedic clinic lists and the Outpatient Physiotherapy waiting list at a single, elective Orthopaedic NHS Trust. Patients will have been assessed in a Specialist Consultant lead clinic by and been given one of the following diagnoses:

1. Lateral Hip pain
2. Greater Trochanteric Pain Syndrome (GTPS)
3. Trochanteric bursitis.
4. Gluteal tendinopathy

Brief summary: Greater Trochanteric Pain syndrome (GTPS) is a debilitating condition causing pain on the outside of the hip. This study aims to explore the experiences, beliefs and expectations of patients with GTPS, using semi-structured interviews.

Detailed description: Greater Trochanteric Pain syndrome (GTPS) is a debilitating condition causing pain on the outside of the hip. There is growing evidence to suggest that psychological barriers to recovery are present in patients with peripheral pain. The experiences and beliefs of patients suffering with GTPS are unknown. This study aims to explore the experiences, beliefs and expectations of patients with GTPS, using semi-structured interviews to inform the development of interventions for evaluation in future research.

Eligibility criteria: Inclusion Criteria:

* Adults \> 16
* Able to speak and understand the English language
* Patients seen in a Specialist Consultant lead clinic who have been given the diagnosis of lateral hip pain, Greater Trochanteric Pain Syndrome (GTPS), Trochanteric Bursitis or Gluteal Tendinopathy.

Exclusion Criteria:

* Inflammatory conditions
* Systemic / Infective disease
* Previous diagnosis of Fibromyalgia or persistent multi-joint pain.

Primary outcomes:
measure: Framework Method of data analysis.
timeFrame: 10 months
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United Kingdom
facility: The Royal Orthopaedic Hospital NHS Trust
Study officials:
References:
citation: Stephens G, O'Neill S, Mottershead C, Hawthorn C, Yeowell G, Littlewood C. "It's just like a needle going into my hip, basically all of the time". The experiences and perceptions of patients with Greater Trochanteric Pain syndrome in the UK National Health Service. Musculoskelet Sci Pract. 2020 Jun;47:102175. doi: 10.1016/j.msksp.2020.102175. Epub 2020 Apr 29.
Clinical trial NCT02384187: Gabapentin Premedication and Adenotonsillectomy in Pediatric Patients
Official title: The Effects of Oral Gabapentin Premedication on Postoperative Nausea and Vomiting and Early Postoperative Recovery Profile in Pediatric Patients Undergoing Adenotonsillectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Post Operative Nausea and Vomiting (PONV)
Adenotonsillectomy
Keywords: Gabapentin
PONV
Adenotonsillectomy
Pediatrics
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2015-03-10
Enrollment: 140
Sex: ALL
Minimum age (years): 3
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The frequent incidence of postoperative vomiting and severe pain in children undergoing adenotonsillectomy, may delay postoperative oral intake and increase the risk of dehydration. Postoperative nausea and vomiting (PONV) is of multi-factorial origin in this group of patients, with a reported incidence ranging from 23% to 73%.

There is growing evidence that the perioperative administration of gabapentinin in adults is beneficial for preoperative anxiolysis, postoperative analgesia, reduction of postoperative nausea and vomiting, and delirium.

Only few studies in literature explored the analgesic effects of preoperative gabapentin as premedication in pediatric population. However, the antiemetic effect of gabapentin in pediatric patients was not systematically investigated before.


Eligibility criteria: Inclusion Criteria:

* Aged (3-12)
* ASA physical status I or II
* Scheduled for adenotonsillectomy surgery in Abu Elrish Al-Mounira Hospital

Exclusion Criteria:

* Patients who have active infection
* Obstructive sleep apnea
* Cognitive impairment
* Abnormal bleeding profile
* Renal or hepatic dysfunction
* History of allergic reaction to study medications or chronic use of anti-consultants will be excluded.

Primary outcomes:
measure: Incidence of PONV
timeFrame: over the first postoperative 6 hours
Secondary outcomes:
measure: Pediatric Anesthesia Behavior score (PAB)
timeFrame: within10 minutes before the child falls asleep.
measure: Incidence and severity of postoperative delirium
timeFrame: up to 60 minutes after the end of the operation.
measure: Duration of recovery
timeFrame: up to 60 minutes after the end of surgery.
measure: Time to first request of postoperative rescue analgesics.
timeFrame: over the first postoperative 6 hours
measure: Postoperative analgesic consumption
timeFrame: over the first postoperative 6 hours
measure: Objective pain scale (OPS)
timeFrame: over the first postoperative 6 hours
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Kasr Al Ainy
Study officials:
affiliation: Cairo University
name: Mohamed Abdulatif, Professor of Anesthesia
role: STUDY_CHAIR
References:
Clinical trial NCT06546787: The Effect of Interpersonal Relationships Psychotherapy on Breast Cancer Patients
Official title: The Effect of Interpersonal Relationships Psychotherapy on Depression, Emotion Regulation and Social Support Levels in Breast Cancer Patients With Depression Risk: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Breast Cancer Patients Diagnosed
Keywords: Depression
Emotion Regulation
Social Support
Interpersonal Relationships
Breast Cancer
Lead sponsor: Koç University
Sponsor class: OTHER
First posted: 2024-08-09
Enrollment: 42
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled trial
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study is planned to examine the effect of Interpersonal Relationship Psychotherapy on depression, interpersonal emotion regulation and multidimensional perceived social support levels of breast cancer patients with depression risk.

Detailed description: There are not enough studies showing the effect of IPT, which is an evidence-based psychotherapy that works on problem areas such as role change that may occur with the disease and provides support for recognizing and using social support mechanisms, on cancer patients. This study is thought to make a significant contribution to the literature, especially in terms of making family support, which has an important place in social support systems, available to patients, intervening in interpersonal emotion regulation problems that may occur in patients and affecting depression levels.

Eligibility criteria: Includes Criteria

* Ability to communicate in Turkish
* Diagnosed with Stage-II and Stage-III breast cancer
* Continuing outpatient treatment
* Four points on the Primary Care Depression Screening Scale
* Internet connection
* Has a phone that can use the zoom app to continue conversations to be
* To be able to use the Zoom app

Exclusion Criteria

* Being a pediatric oncology/hematology patient
* Diagnosed with stage -IV breast cancer
* Taking psychopharmacological medication
* To have received KIPT within the last year

Primary outcomes:
measure: Beck Depression Screening Scale for Primary Care
timeFrame: Through study completion, an average of 6 months
measure: Interpersonal relationships emotion regulation scale
timeFrame: Through study completion, an average of 6 months
measure: Multidimensional Perceived Social Support Scale:
timeFrame: Through study completion, an average of 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Koc University
state: Nursing Department
Study officials:
References:
Clinical trial NCT00076687: Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Stroke
Muscle Spasticity
Motor Neuron Disease
Lead sponsor: Allergan
Sponsor class: INDUSTRY
First posted: 2004-02-26
Enrollment: 155
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the safety of injections of botulinum toxin Type A in patients with reduced lung function and focal upper limb poststroke spasticity


Eligibility criteria: Inclusion Criteria:

* Abnormal pulmonary function test results;
* focal, upper limb spasticity, upper motor neuron syndrome

Exclusion Criteria:

* Previous exposure to botulinum toxin of any serotype

Primary outcomes:
measure: Change From Baseline in Forced Vital Capacity (FVC)
timeFrame: Baseline, Week 6
measure: Change From Baseline in Forced Expiratory Volume (FEV1)
timeFrame: Baseline, Week 6
Secondary outcomes:
measure: Change From Baseline in FEV1/FVC Ratio
timeFrame: Baseline, Week 6
measure: Change From Baseline in Ashworth Scale
timeFrame: Baseline, Week 6
Other outcomes:
Locations:
city: Miami
country: United States
state: Florida
city: Prague
country: Czech Republic
city: Szeged
country: Hungary
city: Warsaw
country: Poland
Study officials:
affiliation: Allergan
name: Medical Director
role: STUDY_DIRECTOR
References:
Clinical trial NCT04258787: OCT in Fuchs' Dystrophy
Official title: Evaluating Corneal Edema in Fuchs' Endothelial Dystrophy Using Optical Coherence Tomography
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Fuchs Dystrophy
Pseudophakic Bullous Keratopathy
Keywords: Fuchs
Pseudophakic Bullous Keratopathy
Optical Coherence Tomography (OCT)
PBK
Lead sponsor: Oregon Health and Science University
Sponsor class: OTHER
Collaborators: name: National Eye Institute (NEI)
First posted: 2020-02-06
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults age 18 or older with Fuchs' or PBK

Brief summary: This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.


Eligibility criteria: Inclusion Criteria:

* Damaged or diseased corneal endothelium from Fuchs' or PBK
* Willingness to commit to required study visits

Exclusion Criteria:

* Prior Endothelial Keratoplasty (EK) or any other surgery except uncomplicated cataract surgery
* Presence of a condition that increases the probability for treatment failure (e.g., heavily vascularized cornea, uncontrolled uveitis)
* Other primary endothelial dysfunction conditions (e.g., posterior polymorphous corneal dystrophy and congenital hereditary corneal dystrophy, iridocorneal endothelial syndrome)
* Central sub-epithelial or stromal scarring that could impact post-operative clarity assessment
* Peripheral anterior synechiae in the angle greater than 3 clock hours
* Hypotony
* Uncontrolled glaucoma
* Visually significant optic nerve or macular pathology

Primary outcomes:
measure: Corneal Epithelial Edema/Haze
timeFrame: up to 2 years
measure: Corneal Stromal Edema/Haze
timeFrame: up to 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Portland
country: United States
facility: Oregon Health & Science University
state: Oregon
Study officials:
affiliation: Oregon Health and Science University
name: Winston Chamberlain, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06464887: A Predictive Model for Recurrent Acute Pancreatitis
Official title: Construction and Validation of an Early Prediction Nomogram for Recurrent Acute Pancreatitis Based on the MIMIC Database
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Pancreatitis
Keywords: Recurrent acute pancreatitis
Prediction
Lead sponsor: Yangzhou University
Sponsor class: OTHER
First posted: 2024-06-18
Enrollment: 659
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: We collected data from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and from patients with acute pancreatitis in the Department of Gastroenterology of Clinical Medical College of Yangzhou University between January 2016 and December 2017, forming the primary and validation cohort, respectively.

Brief summary: The goal of this observational study is to learn about recurrent acute pancreatitis (RAP) .The main questions it aims to answer are:

1. What are the risk factors for RAP?
2. How to predict RAP?

All patients with acute pancreatitis will be given standardized treatment for the condition.

The researchers will compare the RAP group with the non-RAP group to find the risk factors for RAP.

Detailed description: Investigators retrospectively collected data from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and from patients with acute pancreatitis (AP) in the Department of Gastroenterology of Clinical Medical College of Yangzhou University between January 2016 and December 2017, forming the primary and validation cohort, respectively.

Eligibility criteria: Inclusion Criteria:

* Meeting the diagnostic criteria of acute pancreatitis (AP)
* Age ≥18 years
* Systematic examination and diagnostic information were available after admission

Exclusion Criteria:

* Not the first episode of AP
* The duration of hospital stay was less than 24 hours
* Died within the first episode of AP
* A history of chronic pancreatitis or tumor
* Pregnancy

Primary outcomes:
measure: Number of Participants Who Experience Recurrent Acute Pancreatitis
timeFrame: From admission to 3 years after discharge.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Johnson AEW, Bulgarelli L, Shen L, Gayles A, Shammout A, Horng S, Pollard TJ, Hao S, Moody B, Gow B, Lehman LH, Celi LA, Mark RG. MIMIC-IV, a freely accessible electronic health record dataset. Sci Data. 2023 Jan 3;10(1):1. doi: 10.1038/s41597-022-01899-x.
citation: Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013 Jan;62(1):102-11. doi: 10.1136/gutjnl-2012-302779. Epub 2012 Oct 25.
Clinical trial NCT03170687: Comparative Outcomes Between Foot Cast and Short Leg Cast in the Patients With Acute Closed Fracture of Proximal Fifth Metatarsal (Zone II)
Official title: Comparative Outcomes Between Foot Cast and Short Leg Cast in the Patients With Acute Closed Fracture of Proximal Fifth Metatarsal (Zone II)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acute Closed Fracture of Proximal Fifth Metatarsal (Zone II)
Lead sponsor: Ramathibodi Hospital
Sponsor class: OTHER
Collaborators: name: Police General Hospital
First posted: 2017-05-31
Enrollment: 72
Sex: ALL
Minimum age (years): 15
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to compare outcomes of short leg cast and foot cast for treatment acute fifth metatarsal fracture (Zone II).

Detailed description: A randomized controlled trial will conducts between January 2017 and January 2019, participants with acute fifth metatarsal fracture (Zone II) will recruit for this study at the orthopedic outpatient clinic of a police general hospital, Bangkok, Thailand. A total of 100 patients will randomly allocate to receive foot cast or short leg cast. acute closed fracture of proximal fifth metatarsal (zone II) patients.

Eligibility criteria: Inclusion Criteria:acute closed fracture of proximal fifth metatarsal (zone II) with following criteria

1. History of trauma and pain at lateral side of foot
2. Tenderness at base of 5th metatarsal
3. Radiographic finding shown fracture line at proximal 5th metatarsal bone

Exclusion Criteria:

1. more than 1 week
2. comminuted or multiple fracture
3. Open fracture
4. Ligament and tendon injury
5. Previous injury complication: nonunion, delayed union
6. Malignancy
7. refuse to inform consent

Primary outcomes:
measure: VAS
timeFrame: 8 weeks
Secondary outcomes:
measure: AOFAS
timeFrame: 8 weeks
measure: union rate
timeFrame: 8 weeks
measure: complication
timeFrame: 8 weeks
Other outcomes:
measure: rescue medication
timeFrame: 8 weeks
Locations:
city: Bangkok
country: Thailand
facility: Jatupon Kongtharvonskul
state: Select...
Study officials:
References:
Clinical trial NCT02414087: Therapeutic Effects of Customized Insoles on Children With Flat Foot
Official title: Therapeutic Effects of Customized Insoles on Children With Flat Foot
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Flat Foot
Keywords: flat foot
therapeutic effect
insoles
children
Lead sponsor: Taipei Medical University
Sponsor class: OTHER
First posted: 2015-04-10
Enrollment: 52
Sex: ALL
Minimum age (years): 3
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Using double blind, randomized controlled design to study the short-term therapeutic effects of customized arch-support shoe insoles to children with flat foot.

Detailed description: A total of 52 children with flat foot will be collected. The participants will be randomized into two groups, including study group (insoles group) and control group (without insole group).

All participants in the insoles group will be evaluated at baseline, that is before the customized full-length shoe insoles are prescribed. All the evaluations, including physical functional ability, balance, physical activity, functional performance, and quality of life will be re-evaluated up to 12 weeks after shoe insoles wearing in the insoles group.

The control group will be evaluated at the baseline and up to 12 weeks.

Eligibility criteria: Inclusion Criteria:

* flat foot

Exclusion Criteria:

* age less than 3 years old or older than 10 years old
* pathological flat foot

Primary outcomes:
measure: health related quality of life (Pediatric Quality of Life Inventory (PedQoL)
timeFrame: baseline and up to 12 weeks
Secondary outcomes:
measure: functional performance (Pediatric Outcome Data Collection Instrument)
timeFrame: baseline and up to 12 weeks
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Shin Kong Wu Ho-Su Memorial Hospital
Study officials:
affiliation: Shin Kong Wu Ho-Su Memorial Hospital; Taipei Medical University
name: Ru-Lan Hsieh, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Evans AM, Rome K, Carroll M, Hawke F. Foot orthoses for treating paediatric flat feet. Cochrane Database Syst Rev. 2022 Jan 26;1(1):CD006311. doi: 10.1002/14651858.CD006311.pub4.
citation: Evans AM, Rome K, Carroll M, Hawke F. Foot orthoses for treating paediatric flat feet. Cochrane Database Syst Rev. 2022 Jan 14;1(1):CD006311. doi: 10.1002/14651858.CD006311.pub3.
Clinical trial NCT00334087: The Relation Between Pregnancy,Birth Outcome, Feeding , Oral Hygiene Habits and Early Childhood Caries Development.
Official title: Assessment of Pregnancy History, Birth Outcome, Feeding and Oral Practices With Development of Early Childhood Caries in Offspring of Women Who Have Not Participated in Previous Birth Preparation Class
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Dental Caries
Keywords: primary dental prevention
early childhood caries
prenatal oral care
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2006-06-06
Enrollment: 200
Sex: ALL
Minimum age (years): 36
Maximum age (years): 48
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: DEFINED_POPULATION
Time perspective: OTHER

Brief summary: * 200 children between ages 36 to 48 months will be invited for a regular dental examination
* Parameters to be investigated

  1. Pregnancy history
  2. Birth outcome
  3. Child's general health
  4. Feeding habits
  5. Oral hygiene habits
  6. Dmft caries index
  7. Congenital enamel defects

Detailed description: Severe Early Childhood Caries is a condition whereby very young children suffer multiple caries. The value of a pre- perinatal preventive approach is currently being examined in the dental literature. At Hadassah, a Pilot Study is currently underway to test the feasibility of a comprehensive Baby Clinic designed to prevent Severe Early Childhood Caries. The pilot study in cooperation with the Woman's Health Center and with the midwives and the breastfeeding counselors of the maternity unit. Lectures are given by pediatric dentists to parents of firstborn children attending Hadassah's Birth Preparation Class, emphasis is given to the importance of breastfeeding and other feeding habits in the emotional, physical, nutritional and immunological development of the future baby. In addition the effect of these feeding habits on the dental/oral aspects, relevant for the developing dentition.

After birth the parents are invited to come with their babies around 12 months for the first dental examination and follow up according to individual risk for caries development. The current proposed study will be a control group from offspring of women who have participated previous Sessions Hadassah's Birth Preparation Class ("Historical Controls" before the Baby Clinic project)

Eligibility criteria: Inclusion Criteria:

* children born in previous Sessions Hadassah's Birth Preparation Class " before the Baby Clinic project)

Exclusion Criteria:

* children not born in previous Sessions Hadassah's Birth Preparation Class " before the Baby Clinic project)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem,
country: Israel
facility: Hadassah Medical Organization
Study officials:
affiliation: Hadassah Medical Organization IRB
name: Evelyn Mamber, DMD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gomez SS, Weber AA. Effectiveness of a caries preventive program in pregnant women and new mothers on their offspring. Int J Paediatr Dent. 2001 Mar;11(2):117-22. doi: 10.1046/j.1365-263x.2001.00255.x.