Clinical trial NCT05113446: MDD(Mild Cognitive Impairment Delirium Dementia) Cohort
Official title: A Prospective, Longitudinal Cohort Study of the Incidence of Dementia After the Onset of Delirium in Patients With Mild Cognitive Impairment: MDD Cohort (Mild Cognitive Impairment Delirium Dementia)
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Delirium
Mild Cognitive Impairment
Dementia
Keywords: delirium
mild cognitive impairment
dementia
Lead sponsor: Keimyung University Dongsan Medical Center
Sponsor class: OTHER
First posted: 2021-11-09
Enrollment: 163
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients admitted to 3 long-term care (LTC) facilities

Brief summary: * Identify the degree of delirium in subjects with mild cognitive impairment and find the risk factors of delirium. Mortality, hospital stay, and medical expenses are analyzed as clinical consequences related to delirium incidence.
* Dementia conversion rate and conversion period of subjects with mild cognitive impairment with delirium and it identifies the effect of delirium on dementia conversion.
* Develop an AI(Artificial intelligence) algorithm for predicting dementia transition in subjects with mild cognitive impairment based on the research results of the 1st, 2nd, and 3rd years.


Eligibility criteria: Inclusion Criteria:

* Patients 65 years of age or older who are admitted to a LTC
* Patients diagnosed with mild cognitive impairment by doctors
* Patients with a score of 18 or more and 23 or less on the Mini-Mental State Examination

Exclusion Criteria:

* Patients unable to measure the delirium assessment tool, The Short Confusion Assessment Methods (S-CAM) (Inouye, 2014) due to severe vision and hearing problems
* Patients with serious psychiatric or neurological diagnosis,Patients who expire or were transferred on the day of admission -
* Patients receiving emergency treatment at the time of the delirium assessment or unable to measure or intervene with S-CAM due to hospital circumstances

Primary outcomes:
measure: Delirium incidence in participants with mild cognitive impairment
timeFrame: The number of subjects evaluated as positive in the delirium assessment using S-CAM for 30 days from the 1st day of study participation is statistically calculated.
measure: Dementia conversion rate and transition period in participants with mild cognitive impairment
timeFrame: The participant's dementia conversion is checked in units of 1 month, and the period until conversion to dementia is analyzed in units of 12 months for 36 months.
Secondary outcomes:
measure: Risk factors affecting participants' delirium
timeFrame: On the first day of data collection, the characteristics of subjects are collected through medical records. After 12 months, the risk factors affecting the occurrence of delirium among the characteristics of the subject are analyzed.
measure: Mortality
timeFrame: It is statistically calculated in 30-day, 60-day, 12-month, 24-month, and 36-month increments.
measure: hospital length of stay
timeFrame: The period from hospitalization to discharge is calculated in days and analyzed in units of 12 months.
measure: healthcare costs
timeFrame: From the healthcare costs consumed during the hospital length of stay, the direct healthcare costs used only for treatment are calculated in won units and analyzed in units of 12 months.
Other outcomes:
Locations:
city: Daegu
country: Korea, Republic of
facility: Yangsan Seoul long-term care (LTC) facilities
state: Gyeongsangnam-do,
city: Daegu
country: Korea, Republic of
facility: Gunsan Chamsarang long-term care (LTC) facilities
state: Jeollabuk-do
Study officials:
References: