louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05016635: Disability-adjusted Life Years in a Senegalese Cohort of Patients With Subarachnoid Hemorrhage
Official title: Disability-adjusted Life Years in a Senegalese Cohort of Patients With Subarachnoid Hemorrhage
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Disability Adjusted Life Years of Sub-arachnoid Hemorrhage in Senegalese Cohort
Lead sponsor: Association of Future African Neurosurgeons, Yaounde, Cameroon
Sponsor class: OTHER
First posted: 2021-08-23
Enrollment: 388
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: We recruited 448 patients between 2011 and 2020. However, 60 patients (13.4%) had incomplete records and were excluded from the analysis. Herein we present the retrospective analysis of the 388 patients (86.6%) with complete records. We received a median of 40.0 patients annually (IQR=51.5), and a peak was observed in 2017 when 76 SAH patients were admitted at our institution.

Brief summary: Subarachnoid hemorrhage (SAH) is the extravasation of blood into the subarachnoid space from traumatic or nontraumatic origin. There is a paucity of data on the burden of SAH in African countries. In this study, we analyzed data from patients in the largest neurovascular center in Senegal to determine the sex- and age-adjusted burden of SAH in Senegal.

Detailed description: The Fann Teaching Hospital (Dakar, Senegal) institutional review board authorized this study. Consent was obtained from adult patients and the parents/legal guardians of children. Patient data were stored in a password-protected Excel spreadsheet, and this spreadsheet was stored on a hard drive. Only the authors had access to the data.

Eligibility criteria: Inclusion Criteria:

* Sub-arachnoid Hemorrhage admission

Exclusion Criteria:

* Not admitted for sub-arachnoid hemorrhage

Primary outcomes:
measure: Disability Adjusted Life Years
timeFrame: 9 years
Secondary outcomes:
Other outcomes:
Locations:
city: Dakar
country: Senegal
facility: Fann Teaching Hospital
Study officials:
References:
Clinical trial NCT01710735: Skeletal Muscle Contractility, Self-reported Pain and Tissue Sensitivity in Females With Neck/Shoulder Pain and Trapezius MFTrPs
Official title: Skeletal Muscle Contractility, Self-reported Pain and Tissue Sensitivity in Females With Neck/Shoulder Pain and Upper Trapezius Myofascial Trigger Points- a Randomized Intervention Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myofascial Pain Syndrome
Keywords: TP
Myofascial pain
Lead sponsor: University of Southern Denmark
Sponsor class: OTHER
Collaborators: name: Lundbeck Foundation
name: Dansk Kiropraktor Fond
name: IMK Almene Fond
First posted: 2012-10-19
Enrollment: 80
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 46
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: In relation to Myofascial Triggerpoints (MFTrPs) of the upper Trapezius, this study will explore muscle contractility characteristics, the occurrence of post-intervention muscle soreness and the effect of dry needling on muscle contractile characteristics and clinical outcomes.


Eligibility criteria: Inclusion Criteria:

* A clinically relevant MFTrP of the upper Trapezius musculature
* Self-reported pain of ≥3 on an eleven-point numerical pain rating scale (NRS-101).
* BMI less than 31

Exclusion Criteria:

* a history of chronic, systemic pathology (e.g. hemophilia)
* pre-existing neck/shoulder pathology/surgical procedures,
* clinical depression
* health-related legal action
* pregnant
* anti-inflammatory and/or chronic pain medication
* had received dry needling for a shoulder/neck disorder within 6 months prior to the study (to raise the level of patient naiveté) suffered from needle phobia

Primary outcomes:
measure: muscle contractility
timeFrame: 30 minutes
Secondary outcomes:
measure: pressure-pain threshold
timeFrame: 60 seconds
measure: NRS-101
timeFrame: 60 seconds
Other outcomes:
Locations:
city: Odense
country: Denmark
facility: Univ. of Southern Denmark
state: Funen
Study officials:
affiliation: Univ. of Southern Denmark
name: Jan Hartvigsen Hartvigsen, PhD
role: STUDY_DIRECTOR
affiliation: Univ. of Southern Denmark
name: Per Aagaard, PhD
role: STUDY_DIRECTOR
References:
citation: Myburgh C, Hartvigsen J, Aagaard P, Holsgaard-Larsen A. Skeletal muscle contractility, self-reported pain and tissue sensitivity in females with neck/shoulder pain and upper Trapezius myofascial trigger points- a randomized intervention study. Chiropr Man Therap. 2012 Nov 25;20(1):36. doi: 10.1186/2045-709X-20-36.
citation: Hofer KA, Ruonala R, Albert VA. The double-corolla phenotype in the Hawaiian lobelioid genus Clermontia involves ectopic expression of PISTILLATA B-function MADS box gene homologs. Evodevo. 2012 Nov 1;3(1):26. doi: 10.1186/2041-9139-3-26.
Clinical trial NCT01639235: Effects of Secondhand Smoke on Flight Attendant Health
Official title: Cardiopulmonary Effects of Secondhand Smoke Exposure on Flight Attendants
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiopulmonary Disease
Keywords: Secondhand Smoke
Flight Attendants
Lung function
Cardiac function
Reproductive health
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
Collaborators: name: Flight Attendant Medical Research Institute
First posted: 2012-07-12
Enrollment: 592
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This is a cross-sectional observational study of flight attendants exposed to secondhand tobacco smoke.

Brief summary: This is a study on a population of flight attendants who were exposed to occupational secondhand tobacco smoke (SHS). This research will examine associations between flight attendant SHS exposure and development of respiratory illnesses, reproductive problems, and cardiovascular diseases.

Detailed description: The main hypothesis of this study is that exposure to the secondhand tobacco smoke (SHS) in the confined workspace of commercial aircraft prior to the ban of cigarette smoking is responsible for long-term damage on the health of nonsmoking flight attendants. We will compare the data collected from our pre-ban flight attendant participants to age-matched, nonsmoking controls from the NHANES (National Health and Nutrition Examination Survey) database. The results of our study should permit us to determine if SHS exposure is the cause of long-term increased cardiovascular morbidity and risk, as well as increased susceptibility to respiratory illnesses.

Eligibility criteria: Inclusion Criteria:

1. Never smoker flight attendants who began working for airlines before the smoking ban on aircrafts went into effect. Never smoker is defined as those with history of tobacco use of less than 100 cigarettes in their lifetime.
2. SHS exposure for at least 1 year while working with the airlines.

Exclusion Criteria:

1. Less than 1 year of occupational exposure to SHS
2. Smoking more than 100 cigarettes over a lifetime

Primary outcomes:
measure: Characterize the long-term effects of SHS on lung and cardiovascular function in pre-ban flight attendants
timeFrame: 25 minutes
Secondary outcomes:
measure: Clinical Examination
timeFrame: 30 min
measure: Characterize the long term effects of prolonged flight time and SHS on reproductive health
timeFrame: 10 minutes
measure: Characterize the biomarkers of SHS exposure
timeFrame: 10 minutes
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: University of California, San Francisco
state: California
Study officials:
affiliation: University of California, San Francisco
name: Rita Redberg, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01414335: Amino Acid Composition Reduces Frequency of Common Cold. Results of a Controlled Completely Masked Trial
Official title: Amino Acid Composition Reduces Frequency of Common Cold. Results of a Controlled Randomized Completely Masked Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: to Improve the Effectiveness of a Amino Acid Dietary Supplement in Chronic Pharyngeal Infections vs Placebo
Keywords: amino acids
immune system
vitamins
chronic infection
common cold
ear
nose
throat
Lead sponsor: Kyberg Vital GmbH
Sponsor class: INDUSTRY
First posted: 2011-08-11
Enrollment: 145
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate the effectiveness of a dietary supplement with high dosage of amino acids and vitamins in the treatment of acute and chronic infection of pharyngeal area known as common cold. T


Eligibility criteria: Inclusion Criteria:

men and women with at least two episodes of common cold and infection of ear, nose and pharyngeal area.

Exclusion Criteria:

* people with severe infection like pneumonia, patients expecting an in-patient treatment during the trial, pregnant or breast feeding and people not able to understand the procedure of the treatment

Primary outcomes:
measure: outcome of efficacy
timeFrame: 3 month treatment
Secondary outcomes:
measure: outcome of efficacy
timeFrame: 3 month treatment
Other outcomes:
Locations:
city: Oberhaching
country: Germany
facility: Kyberg Vital - Doris Meister
state: Bavaria
Study officials:
References:
Clinical trial NCT06720935: Use of Coils During Percutaneous Coronary Intervention
Official title: Contemporary Use of Coils During Percutaneous Coronary Intervention: From the Multicenter COILSEAL Registry
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Percutaneous Coronary Intervention (PCI)
Coronary Artery Disease
Keywords: Coils
Coronary Artery Perforation
Coronary Fistulas
Coronary aneurysm
Lead sponsor: San Luigi Gonzaga Hospital
Sponsor class: OTHER
First posted: 2024-12-06
Enrollment: 143
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with coronary artery perforation or coronary fistula/aneurysm treated with coils embolization during percutaneous coronary intervention

Brief summary: Use of coils during percutaneous coronary interventions (PCI) is sometimes life-saving and useful althought currently off-label and with unknown clinical outcomes. The study aims to report and compare in-hospital and long-term outcomes of patients undergoing coils implantation for treating coronary perforation or closing coronary aneurysms/fistulas.

Detailed description: Background. Use of coils during percutaneous coronary interventions (PCI) is sometimes life-saving and useful althought currently off-label and with unknown clinical outcomes Objectives. To report and compare in-hospital and long-term outcomes of patients undergoing coils implantation for treating coronary perforation or closing coronary aneurysms/fistulas.

Methods. Among 245.652 PCIs performed in 17 high-volume European centers, patients treated with coils will be identified.

The primary outcome was technical success, defined as the successful sealing coronary perforation or aneurysm/fistulas and procedural success defined as technical success without in-hospital Major Cardiovascular Events (MACe). Long-term MACE and mortality were also reported

Eligibility criteria: Inclusion Criteria:

* Patients with coronary artery perforation or coronary artery fistula/aneurysm suitable treating with coils embolization

Exclusion Criteria:

* Patients without coronary artery disease suitable of coils treatment

Primary outcomes:
measure: Rate of Technical Success
timeFrame: intraprocedural
Secondary outcomes:
measure: Rate of Procedural success
timeFrame: Intraprocedural
Other outcomes:
Locations:
city: Orbassano
country: Italy
facility: San Luigi Gonzaga Hospital
state: Turin
Study officials:
References:
Clinical trial NCT04213235: Educational Materials Development for Physical Activity in CAncer
Official title: E.D.u.CA: a Guidebook to Increase Physical Activity Level in Cancer Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Mixed Cancer
Lead sponsor: Universita di Verona
Sponsor class: OTHER
First posted: 2019-12-30
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: In cancer setting, physical exercise has emerged as an important factor to control cancer-related symptoms and improve patients' quality of life. In addition, the correlation between physical activity and survival is recently consolidating. Nevertheless, several previous studies have shown that the majority of cancer patients are insufficiently active. Written information, for example a guidebook, may be a good oppurtunity, to improve lifestyle. Developing and testing an exercise guidebook, based on Theory of Planned Behavior and specifically designed for cancer patients, may be an effective tool to deliver information and increase physical activity level in this population.


Eligibility criteria: Inclusion Criteria:

* signed informed consent;
* confirmed cancer diagnosis.

Exclusion Criteria:

- sufficient physical activity level.

Primary outcomes:
measure: Physical activity level - using Godin's Leisure Time Exercise Questionnaire (GLTEQ)
timeFrame: Change from baseline physical activity level at 4 weeks
Secondary outcomes:
measure: quality of life - using European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire" (EORTC QLQ C-30)
timeFrame: Change from baseline physical activity level at 4 weeks
measure: Sedentary behavior - using Sedentary Behaviour Questionnaire (SBQ)
timeFrame: Change from baseline physical activity level at 4 weeks
Other outcomes:
Locations:
city: Verona
country: Italy
facility: University of Verona
Study officials:
References:
Clinical trial NCT02831335: Technical Development of Multi-Parametric Renocerebral MRI
Official title: Technical Development of Multi-Parametric Renocerebral MRI
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Aging
Lead sponsor: University of Minnesota
Sponsor class: OTHER
First posted: 2016-07-13
Enrollment: 120
Sex: ALL
Minimum age (years): 21
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Normal participants will be recruited for four age groups with the following age ranges: 21 - 35, 36 -50, 51 - 65 and 66 - 80 years. For each subject group, equal number of male and female subjects will be recruited.

Brief summary: The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.


Eligibility criteria: Inclusion Criteria:

1. English-speaking as primary language
2. No hearing loss or uncorrected vision

Exclusion Criteria:

1. Lacking capacity to consent
2. Having known history of cardiovascular diseases (e.g., clinical stroke)
3. Having acute and chronic obstructive pulmonary disease
4. Having known history of renal diseases (e.g., acute kidney injury)
5. Having known history of cognitive disorder or psychiatric illness
6. Having known history of chemical dependence (e.g., alcohol and narcotics)
7. Being treated with stimulant medications, anticonvulsants, antihypertensives or ß-adrenergic blockers

Primary outcomes:
measure: MRI measured perfusion for each group
timeFrame: Baseline
measure: MRI measured vascular reactivity for each group
timeFrame: Baseline
measure: Cognitive performance for each group
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Minneapolis
country: United States
facility: Center for Magnetic Resonance Research
state: Minnesota
Study officials:
affiliation: University of Minnesota
name: Xiufeng Li, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01949935: Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting
Official title: MIR-CABG: A Randomized, Double-blind, Placebo-controlled, Single-Center Study to Evaluate the Impact of Mupirocin on Infection Rate Post Coronary Artery Bypass Grafting
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Surgical Site Infections
Keywords: Mupirocin
Surgical Site Infections
Coronary Artery Bypass Grafting
Lead sponsor: Horizon Health Network
Sponsor class: OTHER
First posted: 2013-09-25
Enrollment: 974
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The hypothesis is that application of Mupirocin to the nose before and after coronary artery bypass grafting surgery will reduce the incidence of surgical site infections.

Detailed description: Mupirocin applied to the nares is effective in eradicating nasal carriage of Staphylococcus species. Abundant evidence has documented that a majority of gram positive surgical site infections share bacterial phenotypes identical with nasal phage types. Conflicting literature exists regarding the efficacy of mupirocin in reducing the incidence of surgical site infections. A randomized prospective double-blind placebo-controlled trial is needed to help settle this question in the setting of coronary artery bypass grafting surgery where surgical site infections carry significant morbidity, cost, and mortality.

Eligibility criteria: Inclusion Criteria:

* Adults \>18 years old undergoing Coronary Artery Bypass Grafting Surgery (CABG) with or without concomitant cardiac valve surgery or other cardiac surgery,
* Median sternotomy wound
* Capable of informed consent

Exclusion Criteria:

* Allergy to mupirocin or components
* Pregnant or lactating females
* Emergency surgery
* Pre-existing ongoing infection

Primary outcomes:
measure: Surgical Site Infection
timeFrame: <30 days post operation
Secondary outcomes:
measure: Mortality
timeFrame: < or = 30 days post operation
measure: Serious adverse durg effects
timeFrame: < or = 30 day post operation
measure: S. aureus carrier status
timeFrame: < or = 30 day post operation
Other outcomes:
measure: Incidence of subtypes of surgical site infections.
timeFrame: < or = 30 days post operation.
measure: Incidence of pneumonia
timeFrame: < or = 30 days post operation.
Locations:
city: Saint John
country: Canada
facility: New Brunswick Heart Centre, Saint John Regional Hospital
state: New Brunswick
Study officials:
affiliation: New Brunswick Heart Centre
name: Craig D Brown, BSc (Med), MD, FRCSC, FACS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01016535: Care of Child's Hygiene From Zero to Two Years Old
Official title: Care of Child's Hygiene From Zero to Two Years Old: Health Professionals' Perceptions of the Strategy and the Family Caregivers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Children Health Under Two Years Old
Health Professionals
Keywords: Family Health Program
Hygiene
Child Health
Lead sponsor: Faculdade Santa Marcelina
Sponsor class: OTHER
First posted: 2009-11-19
Enrollment: 19
Sex: ALL
Minimum age (years): 1
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children's caregivers from zero to two years old monitored in a health center health professionals of a team of a health center

Brief summary: This study aimed to identify the perceptions of family caregivers and professionals of the Family Health Strategy (FHS) for health care for children from 0 to 2 years, and actions on this issue developed by the FHS.

Detailed description: This study aimed to identify the perceptions of family caregivers and professionals of the Family Health Strategy (FHS) for health care for children from 0 to 2 years, and actions on this issue developed by the FHS. Chosen by a descriptive exploratory with a qualitative approach, consisting of 19 subjects while they were 9 professionals and 10 family caregivers. For data collection was used a semi-tour interview and for the treatment of empirical data, the technique of content analysis recommended by Bardin. For presentation and discussion of results the categories from the speech made the interviewers grouped as the possibility of confrontation between the speaches of the two groups, total of 6 categories: hygienist model: focus on personal hygiene, model medicocêntrico x extended care, environmental risk: the care with hygiene and socioeconomic conditions, family and life experience influence care with hygiene, process work x on caregiver perception of guidance received by the health service, link child / caregiver. The perceptions found in the discourse of professionals and caregivers showed that the biologically vision and focus on the body prevalent in health care, and that such care is still centered in the figure of the doctor because of the historical and cultural hegemony curative.

Eligibility criteria: Inclusion Criteria:

* children under two years old
* professional member of the healthcare team

Exclusion Criteria:

* caregivers who were not relatives
* children who had any physical impairment and/or mental

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Faculdade Santa Marcelina
Study officials:
affiliation: Faculdade Santa Marcelina
name: GIANA MARROCHI
role: PRINCIPAL_INVESTIGATOR
References: