Clinical trial NCT06588439: Cognitive-motor Training in Parkinson Disease
Official title: Cognitive-motor Training on Brain Activity, Cognitive Function, and Walking Ability in People With Parkinson Disease
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Parkinson Disease
Keywords: Cognitive-motor training
Executive function
Gait
Electroencephalography
Lead sponsor: National Yang Ming Chiao Tung University
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 50
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Literature reviews showed the cognitive-motor training that combines cognitive tasks may enhance cognitive functions more effectively than individual interventions. Stepping-based cognitive-motor training has been shown to improve cognitive functions, balance, and gait performance in older adults. However, there is insufficient research evidence on the impact and correlation of this training mode on the walking ability, executive functions, and brain activity changes in people with PD. Therefore, this study is designed to investigate the effects of stepping-based cognitive-motor training on the walking ability, executive functions, and brain activity in people with PD.


Eligibility criteria: Inclusion Criteria:

* Diagnoses of idiopathic Parkinson disease
* Stable dopaminergic medicine ≥ 2 weeks
* Able to walk 10 meters without aid
* Mini-Mental Status Examination ≥ 24 points
* No uncorrected visual or auditory disorders
* Education at least junior high school
* No other disease may affect balance

Exclusion Criteria:

* Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders
* History of brain surgery (e.g. deep brain stimulation)

Primary outcomes:
measure: Gait variability
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Gait speed
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Step length
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Step width
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Single support time
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Double support time
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Frontal Assessment Battery
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Stroop color and word test
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Digit span test
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Event-related potential - N2
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Event-related potential - P300
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Go/Nogo test
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Trail making test
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Secondary outcomes:
measure: Mini-Balance Evaluation Systems Test
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Montreal Cognitive Assessment
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Timed up and go test
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
measure: Parkinson Disease Questionnaire
timeFrame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Yang Ming Chiao Tung University
Study officials:
References: