Clinical trial NCT03155997: Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
Official title: A Randomized, Open-Label, Phase 3 Study of Abemaciclib Combined With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone in Patients With High Risk, Node Positive, Early Stage, Hormone Receptor Positive, Human Epidermal Receptor 2 Negative, Breast Cancer
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Breast Cancer
Keywords: early stage breast cancer
cyclin-dependent kinase (CDK)
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
Collaborators: name: NSABP Foundation Inc
First posted: 2017-05-16
Enrollment: 5637
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the safety and efficacy of the study drug abemaciclib in participants with high risk, node positive, early stage, hormone receptor positive (HR+), human epidermal receptor 2 negative (HER2-), breast cancer.


Eligibility criteria: Inclusion Criteria:

* Women (regardless of menopausal status) or men ≥18 years of age (or per local regulations).
* The participant has confirmed HR+, HER2-, early stage resected invasive breast cancer without evidence of distant metastases.
* The participant must have undergone definitive surgery of the primary breast tumor.
* The participant must have tumor tissue from breast (preferred) or lymph node for exploratory biomarker analysis available prior to randomization.
* Pathologic lymph node involvement and at least one of the following indicating a higher risk of recurrence:

  * 4 or more positive axillary lymph nodes
  * Tumor size of at least 5 centimeters
  * Grade 3 defined as at least 8 points on the Bloom Richardson grading system
  * Ki-67 index by central analysis of ≥20% on untreated breast tissue
* The participant must be randomized within 16 months from the time of definitive breast cancer surgery.
* The participant may receive up to 12 weeks of endocrine therapy until randomization following the last non-endocrine therapy (surgery, chemotherapy, or radiation) whichever is last.
* Participants must have recovered (grade ≤1) from the acute effects of chemotherapy and radiotherapy and from surgical side effects following definitive breast surgery.
* Women of reproductive potential must have a negative blood pregnancy test and agree to use highly effective contraceptive methods.
* The participant has a Eastern Cooperative Oncology Group (ECOG) performance status ≤1.
* The participant has adequate organ function.
* The participant is able to swallow oral medications.

Exclusion Criteria:

* Metastatic disease (including contralateral axillary lymph nodes) or node-negative disease.
* Participants with inflammatory breast cancer.
* Participants with a history of previous breast cancer, with the exception of ipsilateral ductal carcinoma in situ (DCIS) treated by locoregional therapy alone ≥5 years ago. Participants with a history of contralateral DCIS treated by local regional therapy at any time may be eligible. Participants with a history of any other cancer (except non-melanoma skin cancer or carcinoma in situ of the cervix), unless in complete remission with no therapy for a minimum of 5 years from the date of randomization are excluded.
* Females who are pregnant or lactating.
* The participant has previously received treatment with any CDK4 and CDK6 inhibitor.
* The participant is receiving concurrent exogenous reproductive hormone therapy (for example, birth control pills, hormone replacement therapy, or megestrol acetate).
* The participant has previously received endocrine therapy for breast cancer prevention (tamoxifen or aromatase inhibitors) or raloxifene.
* The participant has serious preexisting medical condition(s) that, in the judgment of the investigator, would preclude participation in this study.
* The participant has a personal history of any of the following conditions: syncope of cardiovascular etiology, ventricular arrhythmia of pathological origin or sudden cardiac arrest. Any participant with a history of venous thromboembolism (VTE).
* The participant has active systemic infections or viral load.
* The participant has received an experimental treatment in a clinical trial within the last 30 days or 5 half-lives, whichever is longer.

Primary outcomes:
measure: Invasive Disease Free Survival (IDFS)
timeFrame: Baseline to Recurrence or Death from Any Cause (Up to 32 Months)
Secondary outcomes:
measure: IDFS for Participants With Ki-67 Index ≥20%
timeFrame: Baseline to Recurrence or Death from Any Cause (Approximately 10 Years)
measure: Distant Relapse-Free Survival (DRFS)
timeFrame: Baseline to Distant Recurrence or Death from Any Cause (Up to 32 Months)
measure: Overall Survival (OS)
timeFrame: Baseline to Death from Any Cause (Approximately 10 Years)
measure: Pharmacokinetics (PK): Minimum Steady State Concentration (Cmin,ss) of Abemaciclib
timeFrame: Day 1 (2 hours post-dose), Days 30, 60, 90 post-dose
measure: Change From Baseline on the Functional Assessment of Cancer Therapy - Breast (FACT-B)
timeFrame: Baseline, Follow Up (Approximately 3 Years)
measure: Change From Baseline on the Functional Assessment of Cancer Therapy - Endocrine Symptoms (FACT-ES)
timeFrame: Baseline, Follow Up (Approximately 3 Years)]
measure: Change From Baseline on the Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F)
timeFrame: Baseline, Follow Up (Approximately 3 Years)]
measure: Change From Baseline on the EuroQol Five-Dimension Five-Level Questionnaire (EQ-5D-5L)
timeFrame: Baseline, Follow Up (Approximately 3 Years)]
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama Birmingham
state: Alabama
city: Anchorage
country: United States
facility: Providence Alaska Medical Center
state: Alaska
city: Gilbert
country: United States
facility: Banner MD Anderson Cancer Center
state: Arizona
city: Goodyear
country: United States
facility: Arizona Oncology Associates, P.C. - HOPE
state: Arizona
city: Phoenix
country: United States
facility: St. Joseph's Hospital and Medical Center
state: Arizona
city: Phoenix
country: United States
facility: Mayo Clinic Hospital
state: Arizona
city: Tucson
country: United States
facility: The University of Arizona Cancer Center
state: Arizona
city: Yuma
country: United States
facility: Yuma Regional Cancer Center
state: Arizona
city: Jonesboro
country: United States
facility: St. Bernards Medical Center
state: Arkansas
city: Springdale
country: United States
facility: Highlands Oncology Group
state: Arkansas
city: Beverly Hills
country: United States
facility: Beverly Hills Cancer Center
state: California
city: Burbank
country: United States
facility: Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center
state: California
city: Duarte
country: United States
facility: City of Hope National Medical Center
state: California
city: Fresno
country: United States
facility: California Cancer Associates Research and Excellence
state: California
city: Harbor City
country: United States
facility: Kaiser Permanente
state: California
city: Loma Linda
country: United States
facility: Loma Linda University School of Medicine
state: California
city: Los Angeles
country: United States
facility: Cedars-Sinai Medical Center
state: California
city: Monterey
country: United States
facility: Pacific Cancer Care
state: California
city: Orange
country: United States
facility: St. Joseph Hospital
state: California
city: Sacramento
country: United States
facility: University of California Davis (UC Davis) Comprehensive Cancer Center
state: California
city: San Francisco
country: United States
facility: UCSF Medical Center at Mission Bay
state: California
city: San Marcos
country: United States
facility: California Cancer Associates in Research and Excellence
state: California
city: Santa Cruz
country: United States
facility: Dignity Health Dominican Oncology and Hematology
state: California
city: Vallejo
country: United States
facility: Kaiser Permanente
state: California
city: Boulder
country: United States
facility: USO-Rocky Mountain Cancer Center
state: Colorado
city: Thornton
country: United States
facility: USO-Rocky Mountain Cancer Center
state: Colorado
city: New Haven
country: United States
facility: Yale-New Haven Hospital
state: Connecticut
city: Fort Myers
country: United States
facility: Florida Cancer Specialists - South
state: Florida
city: Gainesville
country: United States
facility: University of Florida College of Medicine
state: Florida
city: Hollywood
country: United States
facility: Millennium Oncology - Hollywood
state: Florida
city: Jacksonville
country: United States
facility: Mayo Clinic in Florida
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Lecanto
country: United States
facility: Florida Cancer Specialists - North
state: Florida
city: Ocala
country: United States
facility: Ocala Oncology, P.A.
state: Florida
city: Tallahassee
country: United States
facility: Tallahassee Memorial Cancer Center
state: Florida
city: Tampa
country: United States
facility: Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center
state: Florida
city: Athens
country: United States
facility: University Cancer & Blood Center, LLC
state: Georgia
city: Atlanta
country: United States
facility: Northside Hospital
state: Georgia
city: Marietta
country: United States
facility: Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
state: Georgia
city: Savannah
country: United States
facility: Summit Cancer Care DBA Candler Medical Oncology Practice
state: Georgia
city: Honolulu
country: United States
facility: University of Hawaii Cancer Center
state: Hawaii
city: Chicago
country: United States
facility: John H. Stroger Hospital of Cook County
state: Illinois
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
city: Naperville
country: United States
facility: Edward Cancer Center
state: Illinois
city: Quincy
country: United States
facility: Quincy Medical Group
state: Illinois
city: Indianapolis
country: United States
facility: Franciscan St. Francis Health
state: Indiana
city: Kokomo
country: United States
facility: Community Howard Oncology Center
state: Indiana
city: Wichita
country: United States
facility: Cancer Center of Kansas
state: Kansas
city: Louisville
country: United States
facility: Univ of Louisville School of Medicine
state: Kentucky
city: Baton Rouge
country: United States
facility: Mary Bird Perkins Cancer Center - Baton Rouge
state: Louisiana
city: Houma
country: United States
facility: Terrebonne General Medical Center
state: Louisiana
city: Brewer
country: United States
facility: Cancer Care of Maine
state: Maine
city: Kennebunk
country: United States
facility: New England Cancer Specialists - Kennebunk
state: Maine
city: Lewiston
country: United States
facility: Central Maine Medical Center
state: Maine
city: Hagerstown
country: United States
facility: Meritus John Marsh Cancer Center
state: Maryland
city: Boston
country: United States
facility: Dana-Farber Cancer Institute
state: Massachusetts
city: Worcester
country: United States
facility: Reliant Medical Group, Inc.
state: Massachusetts
city: Rochester
country: United States
facility: Mayo Clinic in Rochester, Minnesota
state: Minnesota
city: Jackson
country: United States
facility: Jackson Oncology Associates PLLC
state: Mississippi
city: Kansas City
country: United States
facility: HCA Midwest Kansas City, MidAmerica Division, Inc.
state: Missouri
city: Omaha
country: United States
facility: Cancer Alliance of Nebraska
state: Nebraska
city: Omaha
country: United States
facility: Nebraska Methodist Hospital
state: Nebraska
city: Omaha
country: United States
facility: Tennessee Cancer Specialists
state: Nebraska
city: Reno
country: United States
facility: Renown Regional Medical Center
state: Nevada
city: Lebanon
country: United States
facility: Dartmouth Hitchcock Medical Center
state: New Hampshire
city: Basking Ridge
country: United States
facility: Memorial Sloan Kettering - Basking Ridge
state: New Jersey
city: Florham Park
country: United States
facility: Summit Medical Group Cancer Center
state: New Jersey
city: Newark
country: United States
facility: Newark Beth Israel Medical Center
state: New Jersey
city: Paramus
country: United States
facility: The Valley Hospital, Inc.
state: New Jersey
city: Toms River
country: United States
facility: Community Medical Center
state: New Jersey
city: Binghamton
country: United States
facility: Broome Oncology
state: New York
city: New York
country: United States
facility: Weill Cornell Medical College
state: New York
city: Poughkeepsie
country: United States
facility: Vassar Brothers Medical Center
state: New York
city: Stony Brook
country: United States
facility: SUNY At Stony Brook
state: New York
city: White Plains
country: United States
facility: White Plains Hospital
state: New York
city: Cary
country: United States
facility: WakeMed Cancer Care - Waverly Hematology & Medical Oncology
state: North Carolina
city: Hendersonville
country: United States
facility: Margaret R. Pardee Memorial Hospital
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest University Health Sciences
state: North Carolina
city: Canton
country: United States
facility: Aultman Hospital
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals Cleveland Medical Center
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
city: Columbus
country: United States
facility: Columbus Community Clinical Oncology Program
state: Ohio
city: Medford
country: United States
facility: Asante Rogue Regional Medical Center
state: Oregon
city: Portland
country: United States
facility: Oregon Health and Science University
state: Oregon
city: Abington
country: United States
facility: Abington Medical Specialists
state: Pennsylvania
city: Bethlehem
country: United States
facility: St. Luke's Hospital & Health Network
state: Pennsylvania
city: Philadelphia
country: United States
facility: Albert Einstein Healthcare Network
state: Pennsylvania
city: Pittsburgh
country: United States
facility: AHN Allegheny General Hospital
state: Pennsylvania
city: Pittsburgh
country: United States
facility: NSABP Foundation
state: Pennsylvania
city: Pittsburgh
country: United States
facility: PinnacleHealth Cancer Institute
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Univ of Pittsburgh Cancer Inst. (UPCI)
state: Pennsylvania
city: York
country: United States
facility: WellSpan Health/York Cancer Center Oncology Research
state: Pennsylvania
city: Florence
country: United States
facility: McLeod Regional Medical Center
state: South Carolina
city: Greenville
country: United States
facility: St Francis Cancer Center
state: South Carolina
city: Spartanburg
country: United States
facility: Spartanburg Regional Medical Center
state: South Carolina
city: Sioux Falls
country: United States
facility: Sanford USD Medical Center
state: South Dakota
city: Chattanooga
country: United States
facility: Erlanger Health System
state: Tennessee
city: Chattanooga
country: United States
facility: Chattanooga Research and Medicine
state: Tennessee
city: Germantown
country: United States
facility: The West Clinic, PLLC dba West Cancer Center
state: Tennessee
city: Kingsport
country: United States
facility: Urology Associates of Kingsport
state: Tennessee
city: Knoxville
country: United States
facility: Tennessee Cancer Specialists
state: Tennessee
city: Knoxville
country: United States
facility: University of Tennessee Medical Center
state: Tennessee
city: Memphis
country: United States
facility: Baptist Cancer Center
state: Tennessee
city: Nashville
country: United States
facility: Florida Cancer Specialists
state: Tennessee
city: Nashville
country: United States
facility: Sarah Cannon Cancer Center
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology Nashville
state: Tennessee
city: Austin
country: United States
facility: Texas Oncology Cancer Care and Research Center
state: Texas
city: Dallas
country: United States
facility: Texas Oncology-Baylor Charles A. Sammons Cancer Center
state: Texas
city: Dallas
country: United States
facility: University of Texas Southwestern Medical Center at Dallas
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology Fort Worth
state: Texas
city: Houston
country: United States
facility: Oncology Consultants, P.A.
state: Texas
city: Lewisville
country: United States
facility: Texas Oncology P.A.
state: Texas
city: San Antonio
country: United States
facility: University of Texas Health Science Center - San Antonio
state: Texas
city: The Woodlands
country: United States
facility: Arizona Oncology Associates, P.C. - HOPE
state: Texas
city: The Woodlands
country: United States
facility: Comprehensive Cancer Centers of Nevada
state: Texas
city: The Woodlands
country: United States
facility: Illinois Cancer Specialists
state: Texas
city: The Woodlands
country: United States
facility: Miami Cancer Institute at Baptist Health, Inc.
state: Texas
city: The Woodlands
country: United States
facility: Minnesota Oncology/Hematology PA
state: Texas
city: The Woodlands
country: United States
facility: Northwest Cancer Specialists PC
state: Texas
city: The Woodlands
country: United States
facility: Oncology and Hematology Associates of Southwest Virginia Inc
state: Texas
city: The Woodlands
country: United States
facility: Oncology Hematology Care Inc
state: Texas
city: The Woodlands
country: United States
facility: Oncology Hematology West
state: Texas
city: The Woodlands
country: United States
facility: Sansum Clinic
state: Texas
city: The Woodlands
country: United States
facility: Shenandoah Oncology, P.C.
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - Dallas Presbyterian Hospital
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - Denison
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - McAllen
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - McKinney
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - Medical City Dallas
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - Methodist Dallas Cancer Center
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - Paris
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - San Antonio Medical Center
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - The Woodlands
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - Tyler
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology - West Texas
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology Cancer Care and Research Center
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology Denton
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology Fort Worth
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology P.A.
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology- Mesquite
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology-Arlington South
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology-Baylor Charles A. Sammons Cancer Center
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology-Deke Slayton Cancer Center
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology-Plano East
state: Texas
city: The Woodlands
country: United States
facility: Texas Oncology-Plano West
state: Texas
city: The Woodlands
country: United States
facility: US Oncology
state: Texas
city: The Woodlands
country: United States
facility: USO - Texas Oncology, P. A.
state: Texas
city: The Woodlands
country: United States
facility: USO-Maryland Oncology Hematology, P.A.
state: Texas
city: The Woodlands
country: United States
facility: USO-New York Oncology Hematology, P.C
state: Texas
city: The Woodlands
country: United States
facility: USO-Rocky Mountain Cancer Center
state: Texas
city: The Woodlands
country: United States
facility: USO-Southern Cancer Center, P.C.
state: Texas
city: The Woodlands
country: United States
facility: USO-Virginia Oncology Associates
state: Texas
city: The Woodlands
country: United States
facility: Virginia Cancer Specialists
state: Texas
city: The Woodlands
country: United States
facility: Willamette Valley Cancer Institute & Research Ctr.
state: Texas
city: Tyler
country: United States
facility: Texas Oncology - Paris
state: Texas
city: Tyler
country: United States
facility: Texas Oncology - Tyler
state: Texas
city: Salt Lake City
country: United States
facility: Utah Cancer Specialists
state: Utah
city: Burlington
country: United States
facility: The University of Vermont Medical Center Inc.
state: Vermont
city: Fredericksburg
country: United States
facility: Hematology Oncology Associates of Fredericksburg Inc.
state: Virginia
city: Richmond
country: United States
facility: Virginia Commonwealth University (VCU) Medical Center
state: Virginia
city: Auburn
country: United States
facility: MultiCare Regional Cancer Center - Auburn
state: Washington
city: Seattle
country: United States
facility: Swedish Medical Center
state: Washington
city: Berazategui
country: Argentina
facility: Centro de Oncologia e Investigacion Buenos Aires
state: Buenos Aires
city: Mar del Plata
country: Argentina
facility: Instituto de Investigaciones Clinicas Mar del Plata
state: Buenos Aires
city: Pilar
country: Argentina
facility: Hospital Universitario Austral
state: Buenos Aires
city: Caba
country: Argentina
facility: Fundacion CENIT para la Investigacion en Neurociencias
state: Ciudad Autonoma Buenos Aires
city: Buenos Aires
country: Argentina
facility: Hospital Aleman
state: Ciudad Autónoma De Buenos Aires
city: Viedma
country: Argentina
facility: Clinica Viedma
state: Rio Negro
city: Rosario
country: Argentina
facility: Instituto de Oncologia de Rosario
state: Santa Fe
city: San Miguel de Tucuman
country: Argentina
facility: Centro Para la Atención Integral del Paciente Oncologico (CAIPO)
state: Tucumán
city: Buenos Aires
country: Argentina
facility: IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Clinica Adventista de Belgrano
city: Ciudad Autónoma de Buenos Aires
country: Argentina
facility: Instituto Alexander Fleming
city: La Rioja
country: Argentina
facility: Fundación CORI para la Investigación y Prevención del Cáncer
city: Salta
country: Argentina
facility: Consultorio Dr. Miguel Ángel Escudero
city: San Juan
country: Argentina
facility: CER San Juan
city: Tucuman
country: Argentina
facility: Centro Medico San Roque
city: Camperdown
country: Australia
facility: Chris O'Brien Lifehouse
state: New South Wales
city: Darlinghurst
country: Australia
facility: St Vincent's Hospital
state: New South Wales
city: Lismore
country: Australia
facility: Lismore Base Hospital
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital
state: New South Wales
city: Sydney
country: Australia
facility: Mater Hospital Sydney
state: New South Wales
city: Waratah
country: Australia
facility: Calvary Mater Newcastle
state: New South Wales
city: Westmead
country: Australia
facility: Westmead Hospital
state: New South Wales
city: Wollongong
country: Australia
facility: Southern Medical Day Care Centre
state: New South Wales
city: Brisbane
country: Australia
facility: Mater Misericordiae Limited
state: Queensland
city: Southport
country: Australia
facility: Gold Coast University Hospital
state: Queensland
city: Townsville
country: Australia
facility: The Townsville Hospital
state: Queensland
city: Elizabeth Vale
country: Australia
facility: Lyell McEwin Hospital
state: South Australia
city: Kurralta Park
country: Australia
facility: Ashford Cancer Centre Research
state: South Australia
city: Launceston
country: Australia
facility: Launceston General Hospital
state: Tasmania
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: East Melbourne
country: Australia
facility: Epworth Hospital
state: Victoria
city: Melbourne
country: Australia
facility: Peter MacCallum Cancer Centre
state: Victoria
city: Melbourne
country: Australia
facility: Maroondah Hospital
state: Victoria
city: Nedlands
country: Australia
facility: Breast Cancer Research Centre WA
state: Western Australia
city: Subiaco
country: Australia
facility: St John of God Subiaco Hospital
state: Western Australia
city: Graz
country: Austria
facility: Medizinische Universität Graz
state: Steiermark
city: Innsbruck
country: Austria
facility: Medizinische Universitaet Innsbruck
state: Tirol
city: Schwaz
country: Austria
facility: Private Practice - Dr. Hubalek
state: Tirol
city: Vienna
country: Austria
facility: Medizinische Universität Wien
state: Wien
city: Vienna
country: Austria
facility: Universitaetsklinikum Allgemeines Krankenhaus Wien
state: Wien
city: Vienna
country: Austria
facility: Klinik Hietzing
state: Wien
city: Salzburg
country: Austria
facility: Universitätsklinikum Salzburg
city: Brasschaat
country: Belgium
facility: Algemeen Ziekenhuis klina
state: Antwerpen
city: Edegem
country: Belgium
facility: Antwerp University Hospital
state: Antwerpen
city: Brussels
country: Belgium
facility: Cliniques Universitaires Saint-Luc
state: Bruxelles-Capitale, Région De
city: Lodelinsart
country: Belgium
facility: CHU de Charleroi - Hopital Civil Marie Curie
state: Hainaut
city: Hasselt
country: Belgium
facility: Jessa Ziekenhuis
state: Limburg
city: Liege
country: Belgium
facility: Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
state: Liège
city: Libramont
country: Belgium
facility: Centre Hospitalier D'Ardenne - Forget
state: Luxembourg
city: Yvoir
country: Belgium
facility: Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne
state: Namur
city: Sint-Niklaas
country: Belgium
facility: AZ Nikolaas
state: Oost-Vlaanderen
city: Leuven
country: Belgium
facility: UZ Leuven
state: Vlaams-Brabant
city: La Louvière
country: Belgium
facility: Groupe Jolimont
state: Wallonne, Région
city: Liege
country: Belgium
facility: Clinical Chc Montlégia
state: Wallonne, Région
city: Ottignies
country: Belgium
facility: Clinique Saint Pierre
state: Wallonne, Région
city: Brugge
country: Belgium
facility: AZ Sint-Jan Brugge-Oostende AV
state: West-Vlaanderen
city: Ieper
country: Belgium
facility: Jan Yperman ziekenhuis
state: West-Vlaanderen
city: Kortrijk
country: Belgium
facility: AZ Groeninge Campus Kennedylaan
state: West-Vlaanderen
city: Namur
country: Belgium
facility: CHU UCL Namur/Site Sainte Elisabeth
city: Fortaleza
country: Brazil
facility: Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
state: Ceara
city: Brasilia
country: Brazil
facility: Sírio-Libanês Brasilia-Centro de Oncologia-Asa Sul
state: District Federal
city: Goiania
country: Brazil
facility: Hospital Araújo Jorge
state: Goias
city: Londrina
country: Brazil
facility: Hospital de Cancer de Londrina
state: Parana
city: Curitiba
country: Brazil
facility: CIONC - Centro Integrado de Oncologia de Curitiba
state: Paraná
city: Ijui
country: Brazil
facility: ONCOSITE - Centro de Pesquisa Clinica em Oncologia
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital São Lucas da PUCRS
state: Rio Grande Do Sul
city: Rio de Janeiro
country: Brazil
facility: Instituto de Educação, Pesquisa e Gestão em Saúde
state: RJ
city: Lajeado
country: Brazil
facility: Hospital Bruno Born
state: RS
city: Barretos
country: Brazil
facility: Fundação Pio XII - Hospital de Câncer de Barretos
state: Sao Paulo
city: Sao Jose Rio Preto
country: Brazil
facility: Hospital de Base de São José do Rio Preto
state: Sao Paulo
city: São Paulo
country: Brazil
facility: Instituto do Cancer do Estado de Sao Paulo - ICESP
state: SP
city: Ribeirao Preto
country: Brazil
facility: Hospital de Clínicas de Ribeirão Preto
state: São Paulo
city: Santo André
country: Brazil
facility: Faculdade de Medicina do ABC
state: São Paulo
city: Rio De Janeiro
country: Brazil
facility: INCA - Instituto Nacional Do Cancer
city: Sao Paulo
country: Brazil
facility: Instituto D'Or de Pesquisa e Ensino (IDOR)
city: São Paulo
country: Brazil
facility: Hospital Sírio Libanês
city: São Paulo
country: Brazil
facility: Pérola Centro de Pesquisa em Oncologia
city: São Paulo
country: Brazil
facility: IBCC - Núcleo de Pesquisa e Ensino
city: São Paulo
country: Brazil
facility: Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T
city: Ottawa
country: Canada
facility: The Ottawa Hospital - General Campus
state: Ontario
city: Toronto
country: Canada
facility: North York General Hospital
state: Ontario
city: Toronto
country: Canada
facility: Humber River Hospital
state: Ontario
city: Toronto
country: Canada
facility: Unity Health Toronto, St. Michael's Hospital
state: Ontario
city: Montreal
country: Canada
facility: Centre Hospitalier de l'Universite de Montreal
state: Quebec
city: Montreal
country: Canada
facility: Jewish General Hospital
state: Quebec
city: Montreal
country: Canada
facility: Hopital du Sacre-Coeur de Montreal
state: Quebec
city: Quebec City
country: Canada
facility: CHU de Quebec-Hopital de Saint-Sacrement
state: Quebec
city: Sherbrooke
country: Canada
facility: Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitair -T
state: Quebec
city: Beijing
country: China
facility: The Fifth Medical Center of PLA General Hospital
state: Beijing
city: Beijing
country: China
facility: Beijing Cancer Hospital
state: Beijing
city: Fuzhou
country: China
facility: Fujian Medical University Union Hospital-1 Bingfanglou
state: Fujian
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital, Sun-Yat Sen University
state: Guangdong
city: Guangzhou
country: China
facility: Sun Yat-Sen University
state: Guangdong
city: Harbin
country: China
facility: Harbin Medical University Cancer Hospital
state: Heilongjiang
city: Zhengzhou
country: China
facility: Henan Cancer Hospital
state: Henan
city: Changsha
country: China
facility: Hunan Cancer Hospital
state: Hunan
city: Nanjing
country: China
facility: Jiangsu Cancer Hospital
state: Jiangsu
city: Nanjing
country: China
facility: Jiangsu Province Hospital
state: Nanjing
city: Jinan
country: China
facility: Shandong Cancer Hospital
state: Shandong
city: Shanghai
country: China
facility: Shanghai Jiaotong University School of Medicine Ruijin Hospital
state: Shanghai
city: Shanghai
country: China
facility: Fudan University Shanghai Cancer Center
state: Shanghai
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital
state: Zhejiang
city: Hangzhou
country: China
facility: The Second Affiliated Hospital of Zhejiang University School of Medicine
state: Zhejiang
city: Horovice
country: Czechia
facility: Nemocnice Horovice
state: Beroun
city: Brno
country: Czechia
facility: Masarykuv onkologicky ustav
state: Brno-město
city: Ostrava
country: Czechia
facility: Fakultni Nemocnice Ostrava
state: Moravskoslezský Kraj
city: Pardubice
country: Czechia
facility: Multiscan
state: Pardubický Kraj
city: Prague
country: Czechia
facility: Fakultni Thomayerova nemocnice
state: Praha 4
city: Plzen
country: Czechia
facility: FN Plzen Lochotin
city: Copenhagen
country: Denmark
facility: Herlev and Gentofte Hospital
state: Hovedstaden
city: København Ø
country: Denmark
facility: Rigshospitalet
state: Hovedstaden
city: Aarhus
country: Denmark
facility: Aarhus Universitetshospital, Skejby
state: Midtjylland
city: Herning
country: Denmark
facility: Regionshospitalet Herning
state: Midtjylland
city: Aalborg
country: Denmark
facility: Aalborg Universitetshospital, Syd
state: Nordjylland
city: Næstved
country: Denmark
facility: Næstved Sygehus
state: Sjælland
city: Esbjerg
country: Denmark
facility: Sydvestjysk Sygehus Esbjerg
state: Syddanmark
city: Odense
country: Denmark
facility: Odense Universitetshospital
state: Syddanmark
city: Soenderborg
country: Denmark
facility: Sygehus Soenderjylland
state: Syddanmark
city: Vejle
country: Denmark
facility: Vejle Sygehus
state: Syddanmark
city: Jyväskylä
country: Finland
facility: Keski-Suomen Keskussairaala
state: Mellersta Finland
city: Tampere
country: Finland
facility: Tampereen yliopistollinen sairaala
state: Pirkanmaa
city: Vaasa
country: Finland
facility: Vaasan Keskussairaala
state: Pohjanmaa
city: Oulu
country: Finland
facility: Oulun yliopistollinen sairaala
state: Pohjois-Pohjanmaa
city: Kuopio
country: Finland
facility: Kuopion Yliopistollinen Sairaala
state: Pohjois-Savo
city: Pori
country: Finland
facility: Satakunnan Keskussairaala
state: Satakunta
city: Helsinki
country: Finland
facility: Docrates Syöpäsairaala
state: Uusimaa
city: Turku
country: Finland
facility: Turku University Central Hospital
state: Varsinais-Suomi
city: Lahti
country: Finland
facility: Päijät-Häme Central hospital
city: Brest
country: France
facility: Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan
state: Bretagne
city: La Chaussee Saint Victor
country: France
facility: Polyclinique De Blois
state: Centre
city: Dijon
country: France
facility: Centre Georges Francois Leclerc
state: Côte-d'Or
city: Plérin
country: France
facility: Hôpital Privé des Côtes d'Armor- HPCA
state: Côtes-d'Armor
city: Besancon
country: France
facility: CHU de Besancon Hopital Jean Minjoz
state: Doubs
city: Rennes
country: France
facility: Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer
state: Ille-et-Vilaine
city: Montpellier
country: France
facility: Centre de Cancérologie du Grand Montpellier
state: Languedoc-Roussillon
city: Saint Herblain
country: France
facility: Institut de Cancérologie de l'Ouest
state: Loire-Atlantique
city: Nancy
country: France
facility: Polyclinique de Gentilly
state: Meurthe-et-Moselle
city: Le Mans
country: France
facility: Clinique Victor Hugo Le Mans
state: Pays-de-la-Loire
city: Clermont-Ferrand
country: France
facility: Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne
state: Puy-de-Dôme
city: Lyon
country: France
facility: Centre Leon Berard
state: Rhône-Alpes
city: Creteil
country: France
facility: Henri Mondor Hospital
state: Seine-et-Marne
city: Rouen
country: France
facility: Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen
state: Seine-Maritime
city: Avignon
country: France
facility: Sainte Catherine Institut du Cancer Avignon Provence
state: Vaucluse
city: La Roche Sur Yon
country: France
facility: Centre Hospitalier de Vendee Les Oudairies
state: Vendée
city: Paris CEDEX 05
country: France
facility: Institut Curie
city: Freiburg im Breisgau
country: Germany
facility: Praxis für interdisziplinäre Onkologie & Hämatologie
state: Baden-Württemberg
city: Freiburg
country: Germany
facility: Universitätsklinikum Freiburg
state: Baden-Württemberg
city: Friedrichshafen
country: Germany
facility: Private Practice - Dr. Helmut Oettle und Prof.Dr.med. Frank Mayer
state: Baden-Württemberg
city: Ludwigsburg
country: Germany
facility: Klinikum Ludwigsburg
state: Baden-Württemberg
city: Tübingen
country: Germany
facility: Universitätsklinikum Tübingen
state: Baden-Württemberg
city: Ulm
country: Germany
facility: Universitätsklinikum Ulm
state: Baden-Württemberg
city: Amberg
country: Germany
facility: Klinikum St. Marien Amberg
state: Bayern
city: Augsburg
country: Germany
facility: Gemeinschaftspraxis hop-augsburg
state: Bayern
city: Erlangen
country: Germany
facility: Universitätsklinikum Erlangen
state: Bayern
city: München
country: Germany
facility: Klinikum der Ludwig-Maximilians-Universitaet Muenchen
state: Bayern
city: München
country: Germany
facility: Klinikum Rechts Der Isar Der Technischen Universität München
state: Bayern
city: München
country: Germany
facility: Rotkreuzklinikum München gemeinnützige GmbH
state: Bayern
city: Frankfurt
country: Germany
facility: Agaplesion Markus Krankenhaus
state: Hessen
city: Offenbach
country: Germany
facility: Sana Klinikum Offenbach
state: Hessen
city: Langen
country: Germany
facility: Private Practice - Dres. Andreas Köhler und Roswitha Fuchs
state: Hesse
city: Georgsmarienhütte
country: Germany
facility: Franziskus-Hospital Harderberg
state: Niedersachsen
city: Hannover
country: Germany
facility: Gynäkologisch-Onkologische Praxis am Pelikanplatz
state: Niedersachsen
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
state: Niedersachsen
city: Bonn
country: Germany
facility: Universitätsklinikum Bonn
state: Nordrhein-Westfalen
city: Düsseldorf
country: Germany
facility: Universitätsklinikum Düsseldorf
state: Nordrhein-Westfalen
city: Essen
country: Germany
facility: Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung
state: Nordrhein-Westfalen
city: Krefeld
country: Germany
facility: Zentrum fuer ambulante gynaekologische Onkologie (ZAGO)
state: Nordrhein-Westfalen
city: Mönchengladbach
country: Germany
facility: Evangelisches Krankenhaus Bethesda Mönchengladbach gGmbH
state: Nordrhein-Westfalen
city: Münster
country: Germany
facility: Universitätsklinikum Münster - Albert Schweitzer Campus
state: Nordrhein-Westfalen
city: Witten
country: Germany
facility: Marien Hospital Witten
state: Nordrhein-Westfalen
city: Dresden
country: Germany
facility: Universitätsklinikum Carl Gustav Carus
state: Sachsen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel
state: Schleswig-Holstein
city: Gera
country: Germany
facility: SRH Wald-Klinikum Gera gGmbH
state: Thüringen
city: Berlin
country: Germany
facility: Helios Klinikum Berlin-Buch
city: Berlin
country: Germany
facility: Medizinisches Versorgungszentrum Onkologischer Schwerpunkt am Oskar-Helene-Heim
city: Hamburg
country: Germany
facility: Mammazentrum HH - Krankenhaus Jerusalem
city: Hamburg
country: Germany
facility: Kath. Marienkrankenhaus gGmbH
city: Hamburg
country: Germany
facility: Asklepios Kliniken Hamburg
city: Patras
country: Greece
facility: University Hospital of Patras
state: Achaia
city: Athens
country: Greece
facility: Errikos Dunant Hospital Center
state: Attikí (Region)
city: Athens
country: Greece
facility: Agios Savvas Regional Cancer Hospital
state: Attikí
city: Athens
country: Greece
facility: Metropolitan Hospital
state: Attikí
city: Athina
country: Greece
facility: Alexandra Hospital
state: Attikí
city: Chaidari
country: Greece
facility: Attikon General University Hospital
state: Attikí
city: Nea Kifissia
country: Greece
facility: General Oncology Hospital of Kifissia "Agioi Anargiroi"
state: Attikí
city: Thessaloniki
country: Greece
facility: Bioclinic of Thessaloniki
state: Kentrikí Makedonía
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion
state: Krítí
city: Thessaloniki
country: Greece
facility: European Interbalkan Medical Center
state: Thessaloníki
city: Thessaloniki
country: Greece
facility: Euromedica - General Clinic of Thessaloniki
city: Thessaloniki
country: Greece
facility: Papageorgiou General Hospital of Thessaloniki
city: Ioannina
country: Greece
facility: University Hospital of Ioannina
state: Ípeiros
city: Chai Wan
country: Hong Kong
facility: Pamela Youde Nethersole Eastern Hospital
city: Hksar
country: Hong Kong
facility: Queen Mary Hospital
city: Tuen Mun
country: Hong Kong
facility: Tuen Mun Hospital
city: Yau Ma Tei
country: Hong Kong
facility: Queen Elizabeth Hospital
city: Kecskemet
country: Hungary
facility: Bacs-Kiskun Varmegyei Oktatokorhaz
state: Bacs-Kiskun
city: Szolnok
country: Hungary
facility: Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz
state: Jász-Nagykun-Szolnok
city: Budapest
country: Hungary
facility: Szent Margit Kórház
city: Budapest
country: Hungary
facility: Magyar Honvedseg Egeszsegugyi Kozpont
city: Budapest
country: Hungary
facility: Semmelweis University
city: Budapest
country: Hungary
facility: Szent Imre Egyetemi Oktatokorhaz
city: Budapest
country: Hungary
facility: Uzsoki Utcai Kórház
city: Hyderabad
country: India
facility: MNJ Institute of Oncology
state: Andhra Pradesh
city: New Delhi
country: India
facility: Dr. B. L. Kapur Memorial Hospital
state: Delhi
city: Ahmedabad
country: India
facility: HCG Cancer Centre
state: Gujarat
city: Vadodara
country: India
facility: HCG Cancer Centre
state: Gujarat
city: Gurgaon
country: India
facility: Artemis Hospital
state: Haryana
city: Bangalore
country: India
facility: Manipal Hospital
state: Karmnataka
city: Trivandrum
country: India
facility: Regional Cancer Centre
state: Kerala
city: Mumbai
country: India
facility: Tata Memorial Hospital
state: Maharashtra
city: Nasik
country: India
facility: HCG Manavata Cancer Centre
state: Maharashtra
city: Pune
country: India
facility: Grant Medical Foundation - Ruby Hall Clinic
state: Maharashtra
city: Pune
country: India
facility: Deenanth Mangeshkar Hospital and Research Centre
state: Maharashtra
city: Chennai
country: India
facility: Apollo Speciality Hospital - Teynampet
state: Tamil Nadu
city: Kolkata
country: India
facility: Apollo Gleneagles Hospitals
state: West Bengal
city: Kolkata
country: India
facility: Medica Superspecialty Hospital
state: West Bengal
city: Chandigarh
country: India
facility: Post Graduate Institute of Medical Education & Research
city: Beer Sheva
country: Israel
facility: Soroka Medical Center
state: HaDarom
city: Kfar Saba
country: Israel
facility: Meir Medical Center
state: HaMerkaz
city: Petach Tikva
country: Israel
facility: Rabin Medical Center
state: HaMerkaz
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
state: HaMerkaz
city: Rehovot
country: Israel
facility: Kaplan Medical Center
state: HaMerkaz
city: Zerifin
country: Israel
facility: Yitzhak Shamir Medical Center
state: HaMerkaz
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
state: Yerushalayim
city: Jerusalem
country: Israel
facility: Hadassah Medical Center
state: Yerushalayim
city: Haifa
country: Israel
facility: Rambam Health Care Campus
state: Ḥeifā
city: Napoli
country: Italy
facility: University of Naples Federico II
state: Campania
city: Cona
country: Italy
facility: Azienda Ospedaliero Universitaria S.Anna
state: Emilia-Romagna
city: Meldola
country: Italy
facility: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
state: Emilia-Romagna
city: Monza
country: Italy
facility: Fondazione IRCCS San Gerardo dei Tintori
state: Lombardia
city: Milan
country: Italy
facility: Ospedale Fatebenefratelli-Oftalmico
state: Milano
city: Rozzano
country: Italy
facility: Humanitas
state: Milano
city: Rome
country: Italy
facility: Istituto Nazionale Tumori Regina Elena
state: Roma
city: Rome
country: Italy
facility: Azienda Ospedaliera Sant'Andrea
state: Roma
city: Terni
country: Italy
facility: Azienda Ospedaliera Santa Maria
state: TR
city: Bologna
country: Italy
facility: Ospedale Bellaria - Azienda USL di Bologna
city: Brindisi
country: Italy
facility: Ospedale Antonio Perrino
city: Genova
country: Italy
facility: Ospedale San Martino
city: Modena
country: Italy
facility: Azienda Ospedaliero Universitaria
city: Napoli
country: Italy
facility: Istituto Nazionale Tumori IRCCS Fondazione Pascale
city: Padova
country: Italy
facility: Istituto Oncologico Veneto IRCCS
city: Parma
country: Italy
facility: Azienda Ospedaliera Di Parma
city: Torino
country: Italy
facility: Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino
city: Trento
country: Italy
facility: APSS - Presidio Ospedaliero Santa Chiara
city: Nagoya
country: Japan
facility: Aichi Cancer Center Hospital
state: Aichi
city: Chiba-shi
country: Japan
facility: Chiba Cancer Center
state: Chiba
city: Kashiwa
country: Japan
facility: National Cancer Center Hospital East
state: Chiba
city: Matsuyama
country: Japan
facility: National Hospital Organization Shikoku Cancer Center
state: Ehime
city: Kurume
country: Japan
facility: Kurume General Hospital
state: Fukuoka
city: Ōta
country: Japan
facility: Gunma Prefectural Cancer Center
state: Gunma
city: Hiroshima-shi
country: Japan
facility: Hiroshima University Hospital
state: Hiroshima-ken
city: Sapporo
country: Japan
facility: National Hospital Organization Hokkaido Cancer Center
state: Hokkaido
city: Nishinomiya
country: Japan
facility: Hyogo College of Medecine
state: Hyogo
city: Tsukuba-shi
country: Japan
facility: University of tsukuba hospital
state: Ibaragi
city: Isehara
country: Japan
facility: Tokai University Hospital- Isehara Campus
state: Kanagawa
city: Kawasaki
country: Japan
facility: St Marianna University School of Medicine Hospital
state: Kanagawa
city: Yokohama
country: Japan
facility: Kanagawa Cancer Center
state: Kanagawa
city: Aoba-ku, Sendai-shi
country: Japan
facility: KKR Tohoku Kosai Hospital
state: Miyagi
city: Niigata-shi
country: Japan
facility: Niigata Cancer Center Hospital
state: Niigata
city: Osaka Sayama-shi
country: Japan
facility: Kindai University Hospital- Osakasayama Campus
state: Osaka
city: Hidaka
country: Japan
facility: Saitama Medical University International Medical Center
state: Saitama
city: Ina-machi
country: Japan
facility: Saitama Prefectural Cancer Center
state: Saitama
city: Nagaizumi
country: Japan
facility: Shizuoka Cancer Center
state: Shizuoka
city: Shimotsuke
country: Japan
facility: Jichi Medical University Hospital
state: Tochigi
city: Utsunomiya
country: Japan
facility: Tochigi Cancer Center
state: Tochigi
city: Bunkyō-Ku
country: Japan
facility: Juntendo University Hospital
state: Tokyo
city: Chuo Ku
country: Japan
facility: National Cancer Center Hospital
state: Tokyo
city: Chuo-Ku
country: Japan
facility: St. Lukes International Hospital
state: Tokyo
city: Koto
country: Japan
facility: Japanese Foundation for Cancer Research
state: Tokyo
city: Shinagawa-ku
country: Japan
facility: Showa University Hospital
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Medical University Hospital
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: National Center for Global Health and Medicine
state: Tokyo
city: Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Cancer Center
city: Kagoshima
country: Japan
facility: Sagara Hospital
city: Kumamoto
country: Japan
facility: Kumamoto University Hospital
city: Kumamoto
country: Japan
facility: Kumamoto Shinto General hospital
city: Kyoto
country: Japan
facility: Kyoto University Hospital
city: Osaka
country: Japan
facility: National Hospital Organization Osaka Medical Center
city: Osaka
country: Japan
facility: Osaka International Cancer Institute
city: Cheongju-si
country: Korea, Republic of
facility: Chungbuk National University Hospital
state: Chungcheongbuk-do [Chungbuk]
city: Cheonan-si
country: Korea, Republic of
facility: Soon chun hyang University Cheonan Hospital
state: Chungcheongnam-do [Chungnam]
city: Incheon
country: Korea, Republic of
facility: Inha University Hospital
state: Incheon-gwangyeoksi [Incheon]
city: Namdong-gu
country: Korea, Republic of
facility: Gachon University Gil Medical Center
state: Incheon-gwangyeoksi [Incheon]
city: Goyang-si
country: Korea, Republic of
facility: National Cancer Center
state: Kyǒnggi-do
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Kyǒnggi-do
city: Busan
country: Korea, Republic of
facility: Dongnam Institute of Radiological and Medical Sciences
state: Pusan-Kwangyǒkshi
city: Haeundae-gu
country: Korea, Republic of
facility: Inje University Haeundae Paik Hospital
state: Pusan-Kwangyǒkshi
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Severance Hospital Yonsei University Health System
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Ewha Womans University Mokdong Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Chilgok Hospital
state: Taegu-Kwangyǒkshi
city: Torreon
country: Mexico
facility: CIMAB S.A. de C.V.
state: Coahuila
city: México City
country: Mexico
facility: Grupo Medico Camino S.C.
state: Distrito Federal
city: Ciudad de México
country: Mexico
facility: Health Pharma Professional Research, S.A. de C.V.
state: Federal District
city: Guadalajara
country: Mexico
facility: Hospital Civil Fray Antonio Alcalde
state: Jalisco
city: Guadalajara
country: Mexico
facility: Centro Oncológico Internacional (COI)
state: Jalisco
city: Monterrey
country: Mexico
facility: Centro Regiomontano de Investigacion
state: Nuevo Leon
city: Monterrey
country: Mexico
facility: Filios Alta Medicina
state: Nuevo Leon
city: Monterrey
country: Mexico
facility: Private Practice - Dr. Joaquin Reinoso
state: Nuevo León
city: Juchitan
country: Mexico
facility: Centro de Estudios y Prevencion del Cancer
state: Oaxaca
city: Culiacan
country: Mexico
facility: Neurociencias Estudios Clinicos S.C.
state: Sinaloa
city: Toluca de Lerdo
country: Mexico
facility: Centro Hemato Oncologico Privado
state: Toluca
city: Merida
country: Mexico
facility: Medical Care and Research, S.A. de C.V.
state: Yucatan
city: Merida
country: Mexico
facility: Centro de Atención e Investigación Clínica en Oncología
state: Yucatan
city: Chihuahua
country: Mexico
facility: Unidad de Investigacion en Salud
city: Oaxaca
country: Mexico
facility: Oaxaca Site Management Organization SC
city: Puebla
country: Mexico
facility: Unidad Médica Onco-hematológica
city: San Luis Potosí
country: Mexico
facility: Oncológico Potosino
city: Maastricht
country: Netherlands
facility: Maastricht UMC+
state: Limburg
city: Amsterdam
country: Netherlands
facility: Onze Lieve Vrouwe Gasthuis (OLVG)
state: Noord-Holland
city: Den Haag
country: Netherlands
facility: Haga Ziekenhuis locatie Leyweg
state: Zuid-Holland
city: Dordrecht
country: Netherlands
facility: Albert Schweitzer Ziekenhuis, locatie Dordwijk
state: Zuid-Holland
city: Hamilton
country: New Zealand
facility: Waikato Hospital
state: Waikato
city: Palmerston North
country: New Zealand
facility: Palmerston North Hospital
state: Wanganui
city: Auckland
country: New Zealand
facility: Auckland City Hospital
city: Wroclaw
country: Poland
facility: Dolnośląskie Centrum Onkologii we Wrocławiu
state: Dolnośląskie
city: Lublin
country: Poland
facility: Centrum Onkologii Ziemii Lubelskiej
state: Lubelskie
city: Warszawa
country: Poland
facility: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
state: Mazowieckie
city: Warszawa
country: Poland
facility: Luxmed Onkologia sp. z o. o.
state: Mazowieckie
city: Opole
country: Poland
facility: Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Koszarowskiego
state: Opolskie
city: Gdansk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne
state: Pomorskie
city: Gdynia
country: Poland
facility: Szpitale Pomorskie Sp. z o. o.
state: Pomorskie
city: Olsztyn
country: Poland
facility: Olsztyński Ośrodek Onkologiczny Kopernik
state: Warmińsko-mazurskie
city: Konin
country: Poland
facility: Przychodnia Lekarska "Komed"
state: Wielkopolskie
city: Poznan
country: Poland
facility: Wielkopolskie Centrum Onkologii
state: Wielkopolskie
city: Lodz
country: Poland
facility: Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
state: Łódzkie
city: Coimbra
country: Portugal
facility: Instituto Portugês de Oncologia de Coimbra Francisco Gentil
city: Lisboa
country: Portugal
facility: Champalimaud Foundation
city: Lisboa
country: Portugal
facility: Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria
city: Porto
country: Portugal
facility: Centro Hospitalar do Porto - Hospital de Santo António
city: Porto
country: Portugal
facility: IPOFG - Porto
city: Bayamon
country: Puerto Rico
facility: Puerto Rico Hematology/Oncology Group
city: San Juan
country: Puerto Rico
facility: UPR Comprehensive Cancer Center
city: Bucuresti
country: Romania
facility: Institutul Oncologic
state: București
city: Cluj-Napoca
country: Romania
facility: Institutul Oncologic
state: Cluj
city: Ovidiu
country: Romania
facility: Ovidius Clinical Hospital OCH
state: Constanta
city: Craiova
country: Romania
facility: Centrul de Oncologie "Sfântul Nectarie"
state: Dolj
city: Otopeni
country: Romania
facility: Radiology Therapeutic Center
state: Ilfov
city: Baia Mare
country: Romania
facility: Oncopremium Team
state: Maramureș
city: Bucuresti
country: Romania
facility: Spitalul Clinic Filantropia
city: Chelyabinsk
country: Russian Federation
facility: Chelyabinsk Regional Oncology Dispensary
state: Chelyabinskaya Oblast'
city: Kaluga
country: Russian Federation
facility: Kaluga Regional Clinical Oncology Center
state: Kalužskaja Oblast'
city: Kursk
country: Russian Federation
facility: Kursk Regional Oncology Dispensary
state: Kurskaya Oblast'
city: Moscow
country: Russian Federation
facility: Fed State Budgetary Inst "N.N. Blokhin Med Center of Oncology" MHRF
state: Moskva
city: Moscow
country: Russian Federation
facility: Burdenko Main Military Hospital
state: Moskva
city: Orenburg
country: Russian Federation
facility: Orenburg Regional Clinical Oncology Dispensary
state: Orenburgskaya Oblast'
city: Samara
country: Russian Federation
facility: Samara Regional Clinical Oncology Center
state: Samarskaya Oblast'
city: Saint Petersburg
country: Russian Federation
facility: Leningrad Regional Oncology Dispensary
state: Sankt-Peterburg
city: Saint-Petersburg
country: Russian Federation
facility: St. Petersburg City Oncological Dispensary - Berezovaya Avenue
state: Sankt-Peterburg
city: St. Petersburg
country: Russian Federation
facility: North-Western State Medical University named after I.I.Mechnikov
state: Sankt-Peterburg
city: St. Petersburg
country: Russian Federation
facility: N.N.Petrov Research Institute of Oncology
state: Sankt-Peterburg
city: St. Petersburg
country: Russian Federation
facility: Saint-Petersburg Scientific-Practical Center of Specialized Kinds of Medical Care (oncological) named afte -T
state: Sankt-Peterburg
city: Kazan
country: Russian Federation
facility: Republican Clinical Oncology Dispensary
state: Tatarstan Republic
city: Volzhsky
country: Russian Federation
facility: Volgograd Regional Oncological Dispensary No. 3
state: Volgogradskaya Oblast'
city: Yaroslavl
country: Russian Federation
facility: Yaroslavl Regional Cancer Hospital
state: Yaroslavskaya Oblast'
city: Moscow
country: Russian Federation
facility: Blokhin Cancer Research Center
city: Riyadh
country: Saudi Arabia
facility: King Abdulaziz Medical City - National Guard Hospital
state: Ar Riyāḑ
city: Riyadh
country: Saudi Arabia
facility: King Fahad Medical City
state: Ar Riyāḑ
city: Dammam
country: Saudi Arabia
facility: King Fahad Specialist Hospital-Dammam
state: Ash Sharqīyah
city: Riyadh
country: Saudi Arabia
facility: King Faisal Specialist Hospital & Research Center
city: Singapore
country: Singapore
facility: National Cancer Center
state: Central Singapore
city: Singapore
country: Singapore
facility: National University Hospital
city: Port Elizabeth
country: South Africa
facility: Cancercare Langenhoven Drive Oncology Centre
state: Eastern Cape
city: Pretoria
country: South Africa
facility: Life Groenkloof
state: Gauteng
city: Pretoria
country: South Africa
facility: Eastleigh Breast Care Center
state: Gauteng
city: Sandton
country: South Africa
facility: Sandton Oncology Medical Group (Pty) Ltd
state: Gauteng
city: Cape Town
country: South Africa
facility: Cancercare Rondebosch Oncology
state: Western Cape
city: George
country: South Africa
facility: GVI Oncology
state: Western Cape
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia
state: Andalucía
city: Oviedo
country: Spain
facility: Hospital Universitario Central de Asturias
state: Asturias
city: Barcelona
country: Spain
facility: Hospital Quiron Barcelona
state: Barcelona [Barcelona]
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
state: Catalunya [Cataluña]
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
state: Catalunya [Cataluña]
city: Santiago de Compostela
country: Spain
facility: CHUS - Hospital Clinico Universitario
state: La Coruna
city: Lleida
country: Spain
facility: Hospital Universitario Arnau de Vilanova de Lleida
state: Lleida [Lérida]
city: Alcorcón
country: Spain
facility: Hospital Universitario Fundacion ALcorcon
state: Madrid, Comunidad De
city: Madrid
country: Spain
facility: Hospital Universitario Ramón y Cajal
state: Madrid, Comunidad De
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
state: Madrid, Comunidad De
city: Pozuelo de Alarcon
country: Spain
facility: Hospital Universitario Quironsalud Madrid
state: Madrid
city: Malaga
country: Spain
facility: Hospital Universitario Virgen de la Victoria
state: Málaga
city: San Cristobal de La laguna
country: Spain
facility: Hospital Universitario de Canarias
state: Santa Cruz De Tenerife
city: Valencia
country: Spain
facility: Hospital Clínico de Valencia
state: Valenciana, Comunitat
city: Barcelona
country: Spain
facility: Parc de Salut Mar - Hospital del Mar
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron
city: Granada
country: Spain
facility: Hospital Universitario San Cecilio
city: Jaen
country: Spain
facility: Complejo Hospitalario de Jaén
city: Madrid
country: Spain
facility: Hospital La Princesa
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañon
city: Madrid
country: Spain
facility: Hospital Clinico San Carlos
city: Madrid
country: Spain
facility: Hospital Universitario HM Sanchinarro
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen de Valme
city: Valencia
country: Spain
facility: Hospital Quirón Salud Valencia
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet
city: Malmö
country: Sweden
facility: Skånes universitetssjukhus Lund
state: Skåne Län [se-12]
city: Umeå
country: Sweden
facility: Norrlands universitetssjukhus
state: Västerbottens Län [se-24]
city: Sundsvall
country: Sweden
facility: Sundsvalls Sjukhus
state: Västernorrlands Län [se-22]
city: Västerås
country: Sweden
facility: Västmanlands sjukhus Västerås
state: Västmanlands Län [se-19]
city: Växjö
country: Sweden
facility: Växjö Centrallasarettet
city: Kaohsiung Niao Sung Dist
country: Taiwan
facility: Chang Gung Memorial Hospital - Kaohsiung
state: Kaohsiung
city: Taipei City
country: Taiwan
facility: Tri-Service General Hospital
state: Taipei
city: Changhua
country: Taiwan
facility: Changhua Christian Hospital
city: Kaohsiung City
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: New Taipei City
country: Taiwan
facility: Taipei Medical University Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taipei City
country: Taiwan
facility: MacKay Memorial Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taipei
country: Taiwan
facility: Koo Foundation Sun Yat-Sen Cancer Center
city: Taoyuan City
country: Taiwan
facility: Chang Gung Medical Foundation-Linkou Branch
city: Istanbul- Fatih
country: Turkey
facility: Istanbul Universitesi Cerrahpasa
state: İstanbul
city: Üsküdar/stanbul
country: Turkey
facility: Acibadem Altunizade Hospital
state: İstanbul
city: Bornova
country: Turkey
facility: Ege University Medicine of Faculty
state: Izmir
city: Izmir, Karsiyaka
country: Turkey
facility: Izmir Medical Park Hospital
state: Izmir
city: Ankara
country: Turkey
facility: Ankara Gülhane Eitim ve Aratrma Hastanesi
state: Kecioren
city: Adana
country: Turkey
facility: Baskent University Dr. Turgut Noyan Research and Training Center
city: Ankara
country: Turkey
facility: Ankara Universitesi Tip Fakultesi Hastanesi
city: Ankara
country: Turkey
facility: Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital
city: Ankara
country: Turkey
facility: Hacettepe Universitesi
city: Antalya
country: Turkey
facility: Akdeniz Universitesi Hastanesi
city: Edirne
country: Turkey
facility: Trakya University Faculty of Medicine
city: Istanbul
country: Turkey
facility: TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
city: Kocaeli
country: Turkey
facility: Kocaeli Üniversitesi
city: Malatya
country: Turkey
facility: İnönü Üniversitesi Turgut Özal Tıp Merkezi
city: Dnipro
country: Ukraine
facility: Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council
state: Dnipropetrovska Oblast
city: Kryvyi Rih
country: Ukraine
facility: Communal Enterprise 'Kryvyi Rih Oncology Dispensary' of the Dnipropetrovsk Regional Council
state: Dnipropetrovska Oblast
city: Odesa
country: Ukraine
facility: Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council
state: Odeska Oblast
city: Poltava
country: Ukraine
facility: Poltava Regional Clinical Oncology Center
state: Poltavska Oblast
city: Vinnytsia
country: Ukraine
facility: Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council"
state: Vinnytska Oblast
city: Lutsk
country: Ukraine
facility: Municipal Enterprise "Volyn Regional Medical Oncology Centre" of the Volyn Regional Council
state: Volynska Oblast
city: Uzhhorod
country: Ukraine
facility: Uzhgorod Central City Clinical Hospital
state: Zakarpatska Oblast
city: Truro
country: United Kingdom
facility: The Royal Cornwall Hospital
state: England
city: Chelmsford
country: United Kingdom
facility: Mid Essex Hospital Services NHS Trust
state: Essex
city: London
country: United Kingdom
facility: North Middlesex Hospital
state: Greater London
city: London
country: United Kingdom
facility: Charing Cross Hospital
state: Hammersmith And Fulham
city: Northwood
country: United Kingdom
facility: Mount Vernon Hospital
state: Hertfordshire
city: Blackpool
country: United Kingdom
facility: Victoria Hospital
state: Lancashire
city: Preston
country: United Kingdom
facility: Royal Preston Hospital
state: Lancashire
city: Boston
country: United Kingdom
facility: Boston Pilgrim Hospital
state: Lincolnshire
city: London
country: United Kingdom
facility: Sarah Canon Research Institute UK
state: London, City Of
city: London
country: United Kingdom
facility: Guy's & St Thomas' NHS Foundation Trust
state: London, City Of
city: Central Middlesbrough
country: United Kingdom
facility: James Cook University Hospital
state: Middlesbrough
city: Edinburgh
country: United Kingdom
facility: Western General Hospital
state: Midlothian
city: Nottingham
country: United Kingdom
facility: Nottingham City Hospital
state: Nottinghamshire
city: Oxford
country: United Kingdom
facility: The Churchill Hospital
state: Oxfordshire
city: Taunton
country: United Kingdom
facility: Musgrove Park Hospital
state: Somerset
city: Guildford
country: United Kingdom
facility: Royal Surrey County Hospital
state: Surrey
city: London
country: United Kingdom
facility: Royal Marsden Hospital
state: Sutton
city: Bradford
country: United Kingdom
facility: Airedale General Hospital
city: Manchester
country: United Kingdom
facility: The Christie
Study officials:
affiliation: Eli Lilly and Company
name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
role: STUDY_DIRECTOR
References:
citation: Toi M, Boyle F, Im YH, Reinisch M, Molthrop D, Jiang Z, Wei R, Sapunar F, Grimes BR, Nabinger SC, Johnston SRD. Adjuvant Abemaciclib Combined with Endocrine Therapy: Efficacy Results in monarchE Cohort 1. Oncologist. 2023 Jan 18;28(1):e77-e81. doi: 10.1093/oncolo/oyac234.
citation: Martin M, Hegg R, Kim SB, Schenker M, Grecea D, Garcia-Saenz JA, Papazisis K, Ouyang Q, Lacko A, Oksuzoglu B, Reeves J, Okera M, Testa L, Shimizu C, Denduluri N, Adamchuk H, Dakhil S, Wei R, Forrester T, Fernandez MM, Zimmermann A, Headley D, Johnston SRD. Treatment With Adjuvant Abemaciclib Plus Endocrine Therapy in Patients With High-risk Early Breast Cancer Who Received Neoadjuvant Chemotherapy: A Prespecified Analysis of the monarchE Randomized Clinical Trial. JAMA Oncol. 2022 Aug 1;8(8):1190-1194. doi: 10.1001/jamaoncol.2022.1488.
citation: Perachino M, Poggio F, Arecco L, Blondeaux E, Spinaci S, Marrocco C, Levaggi A, Lambertini M. Update on Pregnancy Following Breast Cancer Diagnosis and Treatment. Cancer J. 2022 May-Jun 01;28(3):176-182. doi: 10.1097/PPO.0000000000000599.
citation: Polewski MD, Nielsen GB, Gu Y, Weaver AT, Gegg G, Tabuena-Frolli S, Cajaiba M, Hanks D, Method M, Press MF, Gottstein C, Gruver AM. A Standardized Investigational Ki-67 Immunohistochemistry Assay Used to Assess High-Risk Early Breast Cancer Patients in the monarchE Phase 3 Clinical Study Identifies a Population With Greater Risk of Disease Recurrence When Treated With Endocrine Therapy Alone. Appl Immunohistochem Mol Morphol. 2022 Apr 1;30(4):237-245. doi: 10.1097/PAI.0000000000001009.
citation: Rugo HS, O'Shaughnessy J, Boyle F, Toi M, Broom R, Blancas I, Gumus M, Yamashita T, Im YH, Rastogi P, Zagouri F, Song C, Campone M, San Antonio B, Shahir A, Hulstijn M, Brown J, Zimmermann A, Wei R, Johnston SRD, Reinisch M, Tolaney SM; monarchE Committee Members. Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: safety and patient-reported outcomes from the monarchE study. Ann Oncol. 2022 Jun;33(6):616-627. doi: 10.1016/j.annonc.2022.03.006. Epub 2022 Mar 23.
citation: Royce M, Osgood C, Mulkey F, Bloomquist E, Pierce WF, Roy A, Kalavar S, Ghosh S, Philip R, Rizvi F, Mixter BD, Tang S, Pazdur R, Beaver JA, Amiri-Kordestani L. FDA Approval Summary: Abemaciclib With Endocrine Therapy for High-Risk Early Breast Cancer. J Clin Oncol. 2022 Apr 10;40(11):1155-1162. doi: 10.1200/JCO.21.02742. Epub 2022 Jan 27.
citation: Johnston SRD, Harbeck N, Hegg R, Toi M, Martin M, Shao ZM, Zhang QY, Martinez Rodriguez JL, Campone M, Hamilton E, Sohn J, Guarneri V, Okada M, Boyle F, Neven P, Cortes J, Huober J, Wardley A, Tolaney SM, Cicin I, Smith IC, Frenzel M, Headley D, Wei R, San Antonio B, Hulstijn M, Cox J, O'Shaughnessy J, Rastogi P; monarchE Committee Members and Investigators. Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2-, Node-Positive, High-Risk, Early Breast Cancer (monarchE). J Clin Oncol. 2020 Dec 1;38(34):3987-3998. doi: 10.1200/JCO.20.02514. Epub 2020 Sep 20.