Clinical trial NCT04913935: Investigation of Thenar Muscles Morphometric Parameters in Patients With TMC OA
Official title: Investigation of Parameters of Trapeziometacarpal Joint Configuration and Tenar Muscles in Patients With TMC OA
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Thumb Osteoarthritis
Muscle Atrophy or Weakness
Keywords: thumb
trapeziometacarpal osteoarthritis
muscle thickness
muscle cross sectional area
hand function
hand dexterity
pain
pinch strength
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2021-06-04
Enrollment: 24
Sex: FEMALE
Minimum age (years): 35
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with trapeziometacarpal osteoarthritis who were between 35 and 75 years and who had the intellectual capacity to give informed consent for the treatment were included in the study.

Brief summary: In this study, investigators aimed to investigate the morphometric parameters tenar muscles and joint configuration in patients with trapeziometacarpal osteoarthritis (TMC OA) osteoarthritis stages, thenar muscle parameters, radial subluxation rate, functional level and hand dexterity.

Detailed description: Patients diagnosed with trapeziometacarpal osteoarthritis and healthy subjects will be included in the study. Thickness and cross-sectional area measurements of the thenar muscles of the patient and healthy volunteers will be performed by using Shimadzu SDU 1200-Pro ultrasound system with an 8-10 MHz linear probe. To improve the image quality and to avoid muscle compression, water immersion ultrasonography will be preferred and the hands will be positioned in a water-filled plastic container. The thenar muscles will be imaged in hands of each subject.

In this study, poster-anterior radiographic imaging will be performed. The osteoarthritis stage will be determined on the radiographic image. Three different measurements will be performed on radiography: radial subluxation of the first metacarpal base (RS), articular width (AW) of the first metacarpal, and the distance between the ulnar articular facet of the trapezium and the ulnar edge of the metacarpal (U). RS / AW ratio will be calculated.

Because TMC OA caused pain and affect performance, especially during grip activities in the osteoarthritis and control groups will be tested.

Grip strength will also be measured.

Eligibility criteria: Inclusion Criteria:

* Patients with trapeziometacarpal osteoarthritis who were between 35 and 75 years

Exclusion Criteria:

* Patient with De'quervain tenosynovitis, trigger finger, entrapment neuropathy and who had undergone hand surgery were excluded.

Primary outcomes:
measure: Ultrasound-based muscle cross-sectional area of thenar muscles in this study will investigate in TMC OA patients and healthy subjects.
timeFrame: through study completion, an average of 1 year
measure: Ultrasound-based muscle thickness of thenar muscles in this study will investigate in TMC OA patients and healthy subjects.
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: The radial subluxation rate of the first metacarpal.
timeFrame: through study completion, an average of 1 year
measure: Evaluation of functional status of hand
timeFrame: through study completion, an average of 1 year
measure: Grip strength measurement
timeFrame: through study completion, an average of 1 year
measure: Evaluation of functional status of hand
timeFrame: through study completion, an average of 1 year
measure: Pain Assessment
timeFrame: through study completion, an average of 1 year
measure: Pinch strength measurement
timeFrame: through study completion, an average of 1 year
measure: Minnesota hand skill test
timeFrame: through study completion, an average of 1 year
measure: 9 Hole hand skill test
timeFrame: through study completion, an average of 1 year
Other outcomes:
Locations:
city: Altindağ
country: Turkey
facility: Hacettepe University
state: Ankara
Study officials:
affiliation: Hacettepe University
name: ÇİĞDEM AYHAN, ASS. PROF.
role: STUDY_CHAIR
References:
citation: Wolf JM, Oren TW, Ferguson B, Williams A, Petersen B. The carpometacarpal stress view radiograph in the evaluation of trapeziometacarpal joint laxity. J Hand Surg Am. 2009 Oct;34(8):1402-6. doi: 10.1016/j.jhsa.2009.06.030. Epub 2009 Sep 10.
citation: Mohseny B, Nijhuis TH, Hundepool CA, Janssen WG, Selles RW, Coert JH. Ultrasonographic quantification of intrinsic hand muscle cross-sectional area; reliability and validity for predicting muscle strength. Arch Phys Med Rehabil. 2015 May;96(5):845-53. doi: 10.1016/j.apmr.2014.11.014. Epub 2014 Dec 4.
citation: Grechenig W, Peicha G, Weiglein A, Tesch P, Lawrence K, Mayr J, Preidler KW. Sonographic evaluation of the thenar compartment musculature. J Ultrasound Med. 2000 Nov;19(11):733-41. doi: 10.7863/jum.2000.19.11.733.