Clinical trial NCT03484312: Hypertensive Urgency Treatment and Outcomes in a Northeast Thai Population
Official title: Hypertensive Urgency Treatment and Outcomes in a Northeast Thai Population: The Results From the Hypertension Registry Program
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hypertension on Emergence
Lead sponsor: Khon Kaen University
Sponsor class: OTHER
First posted: 2018-03-30
Enrollment: 537
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aged 18 years or older who visited the ER with a diagnosis of HT urgency were consecutively enrolled in the study. Patients who were pregnant or lactating, had secondary causes of hypertension were excluded from the study.

Brief summary: Previous studies have reported a high prevalence of hypertensive (HT) urgency. However, these studies have also reported low rates of serious complications, suggesting that rapid blood pressure (BP) reduction may be unnecessary. There are limited clinical data available on this topic in Asian populations. The investigators aimed to determine the basic characteristics, treatment methods, and outcomes in HT urgency patients, both in the emergency room (ER) and at a two-week follow-up.

Detailed description: Previous studies have reported the high prevalence of hypertensive (HT) urgency. However, these studies have also reported low rates of serious complications, suggesting that rapid blood pressure (BP) reduction may be unnecessary. There are limited clinical data available on this topic in Asian populations. The investigators aimed to determine the basic characteristics, treatment methods, and outcomes in HT urgency patients, both in the emergency room (ER) and at a two-week follow-up.

This was a cohort study conducted at Srinagarind hospital, a tertiary-care level university hospital in Khon Kaen, Thailand. The data collection period was from January 2012 to June 2017. The Khon Kaen University Ethics Committee in Human Research approved the protocol. Patients aged 18 years or older who visited the ER with a diagnosis of HT urgency were consecutively enrolled in the study. Patients who were pregnant or lactating had secondary causes of HT, or had incomplete medical records were excluded from the study Office BP was measured using an upper arm cuff oscillometric BP device. The appropriate cuff size for each individual's arm circumference was used. Three BP readings were taken at 30-second intervals with the patient in a sitting position after five minutes of rest. The average of three BP measurements was used for analysis.

Baseline characteristic data were shown as the mean and standard deviation (SD) or percentage. An independent sample t-test was used to compare between groups for continuous variables including age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), time of treatment, and the number of medications being administered. A probability value \<0.05 was considered statistically significant. All statistical analyses were performed with SPSS for Mac version 20.0, registered to Khon Kaen University.

Eligibility criteria: Inclusion Criteria:

* Patients aged 18 years or older who visited the ER with a diagnosis of HT urgency

Exclusion Criteria:

* Pregnant or lactating
* Secondary hypertension

Primary outcomes:
measure: Systolic and diastolic blood pressure (mm Hg)
timeFrame: Up to 24 hours
measure: Discharge status including 1. discharge to home 2. admit to hospital 3. death 4. refer to another hospital
timeFrame: Up to 24 hours
Secondary outcomes:
measure: Systolic and diastolic blood pressure at first hypertension clinic follow up
timeFrame: 2 weeks after discharge from emergency room
Other outcomes:
Locations:
city: Khon Kaen
country: Thailand
facility: Emergency Medicine, Khon Kaen University
state: Muang
Study officials:
References: