Clinical trial NCT02965365: PATET Ratio to Rule Out Transient Tachypnea of the Newborn
Official title: A Non-invasive Method To Rule Out Transient Tachypnea of the Newborn (TTN) : Pulmonary Artery Acceleration to Ejection Time Ratio
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Transient Tachypnea of the Newborn
Lead sponsor: Kayseri Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2016-11-16
Enrollment: 105
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Singleton pregnancies beyond 34 weeks gestational age, with no congenital fetal abnormalities and without any chronicle maternal disease or pregnancy complication like gestational diabetes, preeclampsia, etc. were included in the study.

Brief summary: This study aims to find out whether diagnosis of Transient Tachypnea of the Newborn(TTN) can be predicted via evaluating pulmonary artery Doppler indices.

Detailed description: Transient Tachypnea of the Newborn(TTN) is the most common diagnosed disease in state of neonatal respiratory distress. However there is not an adequate method to diagnose or rule out TTN.

In several studies pulmonary artery Doppler indices are investigated as the possible indicators of pulmonary function. As a result of these studies, physiological processes in fetal lung maturation were established; pulmonary tissue impedance or resistance decreases with increasing gestational age, leading to increased pulmonary blood flow. In a normal lung maturation process the peak sistolic velocity is reached in midsystole, but in case of any reason disturbing the nornal development process,the peak occurs earlier.

We suggested that TTN, which is a factor increasing pulmonary tissue impedance like respiratory distress syndrome(RDS) and pulmonary hypoplasia, would change pulmonary artery(PA) Doppler indices, thus by the way of evaluating pulmonary artery Doplerr indices, we could predict possible diagnosis of TTN

Eligibility criteria: Inclusion Criteria:

* Singleton pregnancies who delivered beyond 34 weeks gestational age

Exclusion Criteria:

* fetal abnormality, chronicle maternal disease, pregnancy complication (preeclampsia, diabetes, intrauterine growth restriction,etc.)

Primary outcomes:
measure: PATET ratio
timeFrame: 5 minutes
Secondary outcomes:
measure: PA PI
timeFrame: 2 minutes
Other outcomes:
Locations:
city: Kocasinan
country: Turkey
facility: Kayseri Doğumevi
state: Kayseri
Study officials:
affiliation: Kayseri Education and Research Hospital
name: Barış Büke, resident
role: PRINCIPAL_INVESTIGATOR
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