louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04538898: A Retrospective Study Investigating the Factors Related to Non-tuberculous Mycobacterial Pulmonary Disease in Hong Kong
Official title: A Retrospective Study Investigating the Factors Related to Non-tuberculous Mycobacterial Pulmonary Disease in Hong Kong
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Non-Tuberculous Mycobacterial Pneumonia
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2020-09-04
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The Clinical Data Analysis and Reporting System (CDARS) will be queried to identify patients from whom one or more respiratory isolates (namely, sputum, tracheal aspirates, bronchial washing, bronchial aspirates, bronchial trap and bronchoalveolar lavage) of mycobacteria collected in the Prince of Wales Hospital in the period of 2009-2018. Specimen and clinical information is linked through the Clinical Management System (CMS). The clinical history from the CMS will be reviewed to assess the comorbid conditions and baseline demographic information.

Laboratory reported use of DNA probes for identification of Mycobacterium avium complex (MAC), M. avium, Mycobacterium intracellulare, Mycobacterium kansasii, and Mycobacterium gordonae, high-performance liquid chromatography and biochemical will be used to identify rapid growers. For trend analysis, no changes in methods for species identification during the study periods will be reported.

Brief summary: In this retrospective study, we aim to investigate the demographic and clinical features of patients with nontuberculous mycobacteria (NTM) lung disease in our hospital and the trends and diversity of NTM species isolated in the period of 2009-2018.


Eligibility criteria: Inclusion Criteria:

* Patients older than 18 years old.
* patients with one or more respiratory isolates (namely, sputum, tracheal aspirates, bronchial washing, bronchial aspirates, bronchial trap and bronchoalveolar lavage) of mycobacteria collected in the Prince of Wales Hospital in the period of 2009-2018.

Exclusion Criteria:

* none

Primary outcomes:
measure: diversity of nontuberculous mycobacteria species
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Chinese University of Hong
state: Please Select
Study officials:
References:
Clinical trial NCT06360198: The Relationship Between Posture, Sense of Position, Musculoskeletal Discomfort and Anxiety
Official title: The Relationship Between Posture, Sense of Position, Musculoskeletal Discomfort and Anxiety in Asymptomatic Individuals: A Cross-Sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Kyphosis Postural Thoracic
Proprioception
Musculoskeletal System
Anxiety
Lead sponsor: Ankara Yildirim Beyazıt University
Sponsor class: OTHER
First posted: 2024-04-11
Enrollment: 67
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Young people who are asymptomatic in terms of musculoskeletal problems

Brief summary: It is known that posture is affected by various factors such as somatosensation, visual perception and cognition. In addition, it is also thought to affect conditions such as stress and anxiety through receptors. The aim of this study was to investigate the relationship between postural changes such as thoracic kyphosis, musculoskeletal problems, trunk position sense and anxiety in young individuals who were asymptomatic in terms of musculoskeletal problems.


Eligibility criteria: Inclusion Criteria:

* 18 years and older
* Volunteered to participate in the study
* No systemic or neurological disease

Exclusion Criteria:

* Severe visual and hearing problems
* Orthopedic injury or surgery in the last 6 months

Primary outcomes:
measure: Throcic Kyphosis
timeFrame: Baseline
Secondary outcomes:
measure: Trunk Position Sense
timeFrame: Baseline
measure: Musculoskeletal Discomfort
timeFrame: Baseline
measure: Anxiety
timeFrame: Baseline
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara Yıldırım Beyazıt University
Study officials:
References:
Clinical trial NCT04312698: Clinical Trial to Evaluate the Efficacy and Safety of CKD-386
Official title: A Randomized, Double-blind, Multi-center, Therapeutic Confirmatory, Phase III Trial to Evaluate the Efficacy and Safety of D013, D326 and D337 Combination Therapy in Dyslipidemia Patients With Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Dyslipidemia Patients With Hypertension
Lead sponsor: Chong Kun Dang Pharmaceutical
Sponsor class: INDUSTRY
First posted: 2020-03-18
Enrollment: 100
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Clinical Trial to Evaluate the Efficacy and Safety of CKD-386


Eligibility criteria: Inclusion Criteria:

1. Subjects are diagnosed with Dyslipidemia Patients with Hypertension or are being administered anti-hypertension and anti-hypertension drugs after diagnosis.
2. Subjects who agreed to participate in this clinical trial voluntarily.

Exclusion Criteria:

1. Subjects who were satisfied specific blood pressure levels that measured at screening period.
2. Subjects who were satisfied specific lipid levels that measured at screening period.
3. Subjects who cannot participate in a clinical trial based on the PI's judgment.

Primary outcomes:
measure: Change rate from baseline in LDL-C
timeFrame: 8 weeks after drug administrations
measure: Change from baseline in MSSBP
timeFrame: 8 weeks after drug administrations
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Yonsei University Medical Center Severance Hospital
Study officials:
References:
Clinical trial NCT06627998: Study of the Prevalence of Osteo-metabolic Complications in Patients With Thyroid Cancer
Official title: Study of the Prevalence of Osteo-metabolic Complications in Patients With Thyroid Cancer
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cancer of Thyroid
Vertebral Fracture
Osteoporosis
Lead sponsor: IRCCS San Raffaele
Sponsor class: OTHER
Collaborators: name: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
First posted: 2024-10-04
Enrollment: 82
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with thyroid cancers who have been evaluated at the outpatient clinics of the Endocrinology Unit of the IRCCS San Raffaele Hospital and the Nuclear Medicine Unit of the Spedali Civili di Brescia.

Brief summary: This is a multicenter retrospective observational study aimed to evaluate the prevalence of osteo-metabolic complications in patients with thyroid cancer.

Detailed description: Approximately 150-200 outpatients evaluated in the Endocrinology Unit of the IRCCS San Raffaele Hospital and the Nuclear Medicine Unit of the Spedali Civili of Brescia will be included in the study.

During the follow-up visits, patients who meet the inclusion criteria will be offered inclusion in the study. After signing the informed consent, the patient's anamnestic and clinical (biochemical, radiological, anamnestic) data will be retrospectively collected in an electronic database. Sensitive data will be anonymized.

Eligibility criteria: Inclusion Criteria:

* age ≥ 18 years
* Histological diagnosis of Thyroid Carcinoma
* radiological data from chest x-ray in lateral projection in the preoperative evaluation on which the vertebral morphometry
* Signing of the informed consent

Exclusion Criteria:

* Subjects not falling within the previously described criteria are excluded

Primary outcomes:
measure: To estimate the incidence and prevalence of osteoporosis and vertebral fractures in Patients With Thyroid Cancer
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Milan
country: Italy
facility: Andrea Giustina
Study officials:
References:
Clinical trial NCT01214798: A Case of Sesamoid Displacement Causing the First Metacarpophalangeal Joint Locking
Official title: Study of the Second Hospital of Qinhuangdao
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Primary Disease
Keywords: sesamoid displacement,
metacarpophalangeal joint,
radial condylar ridge of the metacarpal head.
Lead sponsor: The Second Hospital of Qinhuangdao
Sponsor class: OTHER
First posted: 2010-10-05
Enrollment: 1
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1 person

Brief summary: Traumatic sesamoid displacement of the first metacarpophalangeal joint can affect thumb function.

Detailed description: Although occurrence is rare, the mechanism of the displacement is commonly complex and varied. Understanding the mechanism is critical for treatment of the disorder. We herein present a locked thumb MCPJ caused by sesamoid displacement.

Eligibility criteria: Inclusion Criteria:

* Traumatic sesamoid displacement

Exclusion Criteria:

* Pathologic sesamoid disorder

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Second Hospital of Qinhuangdao
name: Chenlin Li, M.D.
role: STUDY_CHAIR
References:
Clinical trial NCT04995445: Retrospective Evaluation of the Effect of Ultrasound-guided Obturator Nerve Block on Complications in Transurethral (TUR-M) Resection Surgery for Bladder Side Wall Tumors.
Official title: Retrospective Evaluation of the Effect of Ultrasound-guided Obturator Nerve Block on Complications in Transurethral (TUR-M) Resection Surgery for Bladder Side Wall Tumors.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Efficacy of Peripheral Nerve Blocks on Complications, Morbidity and Mortality
Keywords: Obturator nerve block
complications of transurethral resection
TUR-M
Lead sponsor: Erol Olcok Corum Training and Research Hospital
Sponsor class: OTHER
First posted: 2021-08-09
Enrollment: 115
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: more than 18 years regional anesthesia method was applied The files of patients who underwent Tur-M surgery were reviewed retrospectively.

Brief summary: In this study, the effectiveness of obturator nerve block added to spinal anesthesia in the operation of transurethral resection (TUR-M) of bladder lateral-infrolateral wall tumors on the obturator reflex and related complications was investigated.


Eligibility criteria: retrospective study

Inclusion criteria:

* Patients over the age of 18 who have undergone bladder tumor surgery and whose anesthesia method is spinal anesthesia

Exclusion Criteria:

* under 18 years old , received general anesthesia pregnant and pediatric patient data not used

Primary outcomes:
measure: Effect of ultrasound-guided obturator nerve block on complications in transurethral resection of bladder cancer
timeFrame: 2 year
Secondary outcomes:
measure: Effect of ultrasound-guided obturator nerve block on complications in transurethral resection of bladder cancer
timeFrame: 2 year
Other outcomes:
Locations:
city: Çorum
country: Turkey
facility: Çorum training and research state hospital
Study officials:
References:
Clinical trial NCT03881345: Ongoing Registry of Treatment of Venous Thromboembolism
Official title: Russian Registry of Treatment of Venous Thromboembolism
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Deep Vein Thrombosis
Thromboses, Venous
Thrombosis Embolism
Postthrombotic Syndrome
Pulmonary Embolism
Lead sponsor: Medalp Private Surgery Clinic
Sponsor class: OTHER
Collaborators: name: State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
First posted: 2019-03-19
Enrollment: 5000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing any kind of treatment for venous thromboembolism

Brief summary: Ongoing registration of patients with venous thromboembolism treated by means of antithrombotic therapy, thrombolisys, open surgery, endovenous desobstruction and stenting.

Detailed description: Data of patients with VTE treated in different Russian medical centers are entered in a prospective digital database, and continuously updated.

There is planned to conduct prospective randomized, cohort and observational studies on the site of register

Eligibility criteria: Inclusion Criteria:

* case of venous thrombosis of a limb or pulmonary embolus

Exclusion Criteria:

* no exclusion criteria

Primary outcomes:
measure: Veins patency
timeFrame: Baseline, 3 and 12 months post-intervention
Secondary outcomes:
measure: Postthrombotic syndrome
timeFrame: Baseline, 3 and 12 months post-intervention
measure: QoL SF-36
timeFrame: Baseline, 3 and 12 months post-intervention
measure: QoL AVVQ
timeFrame: Baseline, 3 and 12 months post-intervention
Other outcomes:
Locations:
city: Moscow
country: Russian Federation
facility: Pirogov Russian National Research Medical University
Study officials:
References:
Clinical trial NCT02320045: Study to Evaluate Pharmacokinetics of ITCA 650 in Subjects With Renal Impairment Compared to Normal Subjects
Official title: A Phase 1 Study to Evaluate the Pharmacokinetics of ITCA 650 in Subjects With Mild and Moderate Renal Impairment Compared to the Pharmacokinetics of Subjects With Normal Renal Function
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Renal Insufficiency
Lead sponsor: Intarcia Therapeutics
Sponsor class: INDUSTRY
First posted: 2014-12-19
Enrollment: 38
Sex: ALL
Minimum age (years): 25
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A Phase 1 study to evaluate the pharmacokinetics of ITCA 650 in subjects with mild and moderate renal impairment compared to the pharmacokinetics of subjects with normal renal function


Eligibility criteria: Inclusion Criteria:

* Body mass index between 22 and 40 kg/m²
* Subjects meeting pre-defined estimated glomerular filtration rate criteria and creatinine clearance rate

  * Normal (≥90 mL/min/1.73 m2)
  * Mild (60-89 mL/min/1.73 m2)
  * Moderate (45-59 mL/min/1.73 m2)
  * Moderate (\>30-44 mL/min/1.73 m2)

Exclusion Criteria:

* History of acute metabolic complications
* Uncontrolled Hypertension
* History of Hypersensitivity to Exenatide
* Cardiovascular Disease
* History of Acute or chronic pancreatitis
* Personal or family history of Multiple endocrine neoplasia type 2
* History of Medullary thyroid cancer
* Severe renal failure, End stage renal disease or dialysis

Primary outcomes:
measure: 24-h Area under the Curve at steady state (AUCt,ss)
timeFrame: Approximately 67 Days
Secondary outcomes:
measure: Rate of adverse events
timeFrame: Approximately 67 Days
measure: Severity of adverse events
timeFrame: Approximately 67 Days
measure: Safety laboratory parameters
timeFrame: Approximately 67 Days
measure: Vital signs
timeFrame: Approximately 67 Days
measure: Electrocardiogram
timeFrame: Approximately 67 Days
measure: Physical exam
timeFrame: Approximately 67 Days
Other outcomes:
Locations:
city: Boston
country: United States
facility: Intarcia Therapeutics Inc.
state: Massachusetts
city: Kiel
country: Germany
facility: Study Site
city: Mannheim
country: Germany
facility: Study Site
city: Moenchengladbach
country: Germany
facility: Study Site
Study officials:
References:
Clinical trial NCT04570345: 3 Months Versus 12 Months Dual Antiplatelet Therapy After Drug-eluting Stent Implantation in STEMI
Official title: 3 Months Versus 12 Months Dual Antiplatelet Therapy After Second Generation Sirolimus Stent Implantation in ST-elevation Myocardial Infarction(BULK-STEMI)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: ST Elevation Myocardial Infarction
Lead sponsor: Dong-A University
Sponsor class: OTHER
First posted: 2020-09-30
Enrollment: 1002
Sex: ALL
Minimum age (years): 19
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the clinical outcomes of dual antiplatelet therapy with aspirin and P2Y12 receptor inhibitor vs. ticagrelor monotherapy at 3 months after PCI in patients with ST-elevation myocardial infarction.

Detailed description: The purpose of this study is to compare the use of ticagrelor alone versus P2Y12 receptor inhibitor and aspirin together after PCI among ST-elevation myocardial infarction patients who complete 3-month course of dual antiplatelet therapy. The object of this study is to determine the effectiveness and safety of ticagrelor alone, compared to P2Y12 receptor inhibitor plus aspirin in reducing clinically relevant bleeding and in reducing ischemic adverse events among patients diagnosed with ST-elevation myocardial infarction undergoing PCI with second-generation drug-eluting stent.

Eligibility criteria: Inclusion Criteria:

* Patients ≥ 19 years old
* Patients who received new generation sirolimus-eluting (Osiro®) stent implantation for treating ACS
* Provision of informed consent

Exclusion Criteria:

* Age \> 80 years
* Pregnant women or women with potential childbearing
* Life expectancy \< 1 year

Primary outcomes:
measure: NACE: net clinical adverse event
timeFrame: 12 months after randomization
measure: Major adverse cardiac and cerebrovaascular event(MACCE)
timeFrame: 12 months after randomization
measure: Major bleeding (BARC type 3,5)
timeFrame: 12 months after randomization
Secondary outcomes:
measure: Individual component of MACCE and bleeding episode
timeFrame: 12 months after randomization
Other outcomes:
Locations:
city: Busan
country: Korea, Republic of
facility: Department of Internal Medicine,Dong-A University College of Medicine
Study officials:
affiliation: Dong-A University Hospital
name: Kyungil Park, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02820545: Patient's Perception of Hospital Safety
Official title: Patient's Perception of Hospital Safety: Measure of the Patients' Perception and Correlation With Patient Safety Strategies in the Surgical Care Units
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Patient Safety in Surgical Care Units
Keywords: patient safety culture
hospital
patient perception
healthcare professional perception
sociological
qualitative
questionnaire construct
psychometrics
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2016-07-01
Enrollment: 1277
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients hospitalized in surgical care units

Brief summary: The study aims to construct and validate a self-administrated questionnaire to assess the patients' perception of patient safety in surgical care units. The originality of the study is to perform sociological interviews of hospitalized patients to assess their own perception on the safety of their care and to create corresponding items which will be included in a new questionnaire. In a second step, patients' perception of patient safety will be assessed in numerous surgical care units in France, in order to analyze the psychometric properties of the questionnaire and consequently to validate the questionnaire. The patients' perception will be compared to the healthcare professionals' perception on patient safety and to the patient safety strategies in place in the care units.


Eligibility criteria: Inclusion Criteria:

* Patient hospitalized in a surgical care unit for at least 1 night stay
* Patient hospitalized for a scheduled surgery
* French speaking patient

Exclusion Criteria:

* Ambulatory surgery
* Hospitalization in emergency
* Unable to answer a survey
* Patient transfer from another unit of the same hospital

Primary outcomes:
measure: Patient's perception of patient safety in hospital measured by sociological interviews (qualitative outcome)
timeFrame: During patient's hospital stay, up to 2 weeks
Secondary outcomes:
measure: Care safety perception score
timeFrame: 7 days after patient left hospital
measure: Care safety perception score
timeFrame: The day patient leave hospital, up to 2 weeks
measure: Patient Safety Strategies (PSS) score
timeFrame: During patient's hospital stay, up to 2 weeks
Other outcomes:
Locations:
city: Lyon cedex 03
country: France
facility: Hospices Civils de Lyon, Pole Information Médicale Evaluation Recherche
Study officials:
affiliation: Hospices Civils de Lyon
name: Pauline OCCELLI, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Occelli P, Mougeot F, Robelet M, Buchet-Poyau K, Touzet S, Michel P. Feelings of Trust and of Safety Are Related Facets of the Patient's Experience in Surgery: A Descriptive Qualitative Study in 80 Patients. J Patient Saf. 2022 Aug 1;18(5):415-420. doi: 10.1097/PTS.0000000000000950. Epub 2021 Dec 17.