Clinical trial NCT00202189: Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease (COPD)
Official title: Acute Effects of Inhaled Corticosteroids on Dynamic Airway Function During Rest and Exercise in Chronic Obstructive Pulmonary Disease (COPD)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: COPD
Pulmicort
Budesonide
Chronic
Obstructive
Pulmonary
Disease
Exercise
Emphysema
Lead sponsor: Queen's University
Sponsor class: OTHER
First posted: 2005-09-20
Enrollment: 4
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Human and animal studies have shown that inhaled corticosteroids (ICS) decrease airway blood flow . This effect is immediate (within 30 minutes), transient (lasting 90 minutes), and in animal studies independent of gene expression. In COPD patients, decrease in bronchial blood flow may also decrease mucosal edema, airway resistance and improve small airway function. If such an effect exists, then we should be able to measure improvements in airway conductance and reduce lung hyperinflation, which would have salutary effects on dyspnea and exercise endurance.

To our knowledge, no study has examined the immediate effect of ICS on small airway function in COPD. The purpose of this study is to examine the effects of nebulized Pulmicort on small airway function (spirometry, plethysmographic lung volumes, airways resistance, closing volume, partial flow-volume loop analysis) and exercise endurance in patients with moderate to severe COPD.

HYPOTHESIS

1. Nebulized ICS will immediately improve airway function compared with placebo (nebulized saline).
2. Enhanced lung emptying and reduced operating lung volumes during rest and exercise following ICS therapy will translate acutely into clinically important reductions in exertional dyspnea and improvements in exercise endurance.

Detailed description: This will be a single site, pilot, randomized, double-blinded, placebo-controlled, cross-over study that will be conducted at this centre. Subjects will be required to complete four (4) visits to the laboratory over a one-month period.

At Visit 1, subjects who meet all study inclusion and exclusion criteria, will have a full set of pulmonary function tests (PFT) done and complete a symptom-limited incremental cycle exercise test. At Visit 2, subjects will have a partial set of pulmonary function tests (PFT) done and complete a symptom-limited constant load cycle exercise test. On the third and fourth visit subjects will be randomized to treatment with either nebulized saline or nebulized Pulmicort® in a double blinded, cross-over design, subsequent to which they will have their PFT's and symptom limited constant load exercise testing done.

Eligibility criteria: Inclusion Criteria:

* FEV1 less than/equal to 70 % predicted, FEV1/FVC ratio less than/equal to 70%, and FRC greater than/equal to 120 % predicted
* Moderate to severe chronic activity-related dyspnea (modified Baseline Dyspnea Index focal score less than/equal to 6)
* Clinically stable as defined by no changes in medication dosage or frequency of administration with no exacerbations or hospital admissions in the preceding four weeks
* Males or females greater than 40 years of age;
* A cigarette smoking history of at least 20 pack-years
* Able to perform all study procedures and sign informed consent

Exclusion Criteria:

* History of asthma, atopy or nasal polyps
* Recent history of cardiovascular disease (\< 1 year) or other significant disease that could contribute to dyspnea or exercise limitation
* Oxygen saturation less than 80% during exercise on room air

Primary outcomes:
measure: endurance time
timeFrame: 60 minutes post-inhalation
measure: dyspnea
timeFrame: 60-minutes post-inhalation
Secondary outcomes:
Other outcomes:
Locations:
city: Kingston
country: Canada
facility: Respiratory Investigation Unit
state: Ontario
Study officials:
affiliation: Queen's University-Respiratory Investigation Unit
name: Denis E O'Donnell, MD
role: PRINCIPAL_INVESTIGATOR
References: