louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02169245: Effects of Protein and Fiber at Breakfast on Appetite, Blood Sugar, and Cholesterol
Official title: Relative Effects of Chronic Consumption of Egg Protein at Breakfast With and Without Fiber on Brain Neural Activation, Appetite, Glycemic and Lipemic Control and Self-selected Energy Intake
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Brain Activity
Appetite
Ingestive Behavior
Glucose Control
Cholesterol
Lead sponsor: Purdue University
Sponsor class: OTHER
Collaborators: name: American Egg Board
First posted: 2014-06-23
Enrollment: 20
Sex: ALL
Minimum age (years): 21
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The objectives of the research are to assess the effects of increased protein and fiber intake at breakfast on neural activation in brain regions associated with appetitive drive and reward-driven eating, measures of subjective appetite, and ingestive behavior in overweight adults. Additional outcomes of interest include the effects of the breakfast intervention on blood sugar and cholesterol profiles.

Detailed description: The objectives of the research are to assess the effects of increased protein and fiber intake at breakfast on neural activation in brain regions associated with appetitive drive and reward-driven eating, measures of subjective appetite, and ingestive behavior in overweight adults. Additional outcomes of interest include the effects of the breakfast intervention on 24-hour glucose profile as well as fasting and postprandial glycemic and lipemic regulation. The investigators will test the effects of consuming breakfasts with normal protein/normal fiber (NPNF), normal protein/high fiber (NPHF), high protein/normal fiber (HPNF), and high protein/high fiber (HPHF) for two weeks in a randomized cross-over study.

Eligibility criteria: Inclusion Criteria:

* male or female
* age 21 - 45 years
* BMI 25-29.9 kg/m2

Exclusion Criteria:

* Irregular menstrual cycles
* current smoker
* medications or supplements that affect appetite
* pregnant or lactating
* not weight stable
* acutely ill
* diabetic
* claustrophobic
* any implantation unsafe in magnetic resonance imaging (MRI) environment

Primary outcomes:
measure: Brain activation measured with functional magnetic resonance imaging and its association with measures subjective of appetite, self-selected daily energy intake, and energy intake at an ad libitum lunch.
timeFrame: 16 weeks
Secondary outcomes:
measure: 24-hour blood glucose profile
timeFrame: 16 Weeks
measure: Fasting and postprandial blood glucose, insulin, and lipid concentrations
timeFrame: 16 Weeks
Other outcomes:
Locations:
city: West Lafayete
country: United States
facility: InnerVision West/Purdue MRI Facility
state: Indiana
city: West Lafayette
country: United States
facility: Purdue University
state: Indiana
Study officials:
affiliation: Purdue University Dept of Nutrition Science
name: Wayne W Campbell, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06160245: Core Stabilization Exercises in Forward Head Posture
Official title: Effect of Core Stabilization Exercises on Cervical Sagittal Balance Parameters in Forward Head Posture
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Forward Head Posture
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-12-07
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Based on the reviewed literature, Core Stabilization Exercises (CSEs) have been shown to have positive effects on patients with low back pain. To our knowledge, very few studies have examined the impact of CSEs on neck pain, particularly in patients with forward head posture (FHP), despite that several authors suggested that FHP may be caused by lumbopelvic malalignment.

Therefore, the purpose of the study is to assess how CSEs may affect the cervical sagittal balance parameters (CSB) in patient with FHP.

Detailed description: After the patient fills the consent form, the Craniovertebral angle will be measured by taking a photograph, then this photograph will be analysed by the KINOVEA software.

If the CVA is less than 50 degrees, he/she will have a lateral x-ray on the cervical spine to measure the radiographic variables of the CSB parameters. These variables will be assessed and quantified by Image J software.

The patients will be classified randomly into 2 groups, the intervention and control groups. The intervention will receive CSEs program and Postural Correction Exercises (PCEs) program, but control group will receive only PCEs program.

Both programs will be implemented for 6 weeks 3 times/ week and after 6 weeks, patients will be reassessed again to determine the difference.

Eligibility criteria: Inclusion Criteria:

* CVA less than 50 degrees/ neck pain for about 4 weeks

Exclusion Criteria:

* Vertebrobasilar insufficiency/ cervical surgery/ cervical or TMJ fracture

Primary outcomes:
measure: cervical sagittal vertical alignment
timeFrame: baseline, week 6
measure: T1 slope angle
timeFrame: baseline, week 6
measure: craniovertebral angle
timeFrame: baseline, week 6
Secondary outcomes:
measure: numerical pain rating scale
timeFrame: baseline, week 6
measure: neck disability index
timeFrame: baseline, week 6
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Faculty of physical therapy, Cairo University & AXA One-Health clinics Korba branch
Study officials:
References:
Clinical trial NCT02672345: Systemic Inflammatory Response Evaluation With the Use of Inhaled Anesthetic Sevoflurane During CPB
Official title: Systemic Inflammatory Response Evaluation With the Use of Inhaled Anesthetic Sevoflurane During CPB
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Inflammatory Response
Keywords: Sevoflurane
MicroRNAs
Inflammatory Response
Cytokines
Anesthetics, Inhalation
Macrophage Inflammatory Proteins
Lead sponsor: Instituto Dante Pazzanese de Cardiologia
Sponsor class: OTHER
First posted: 2016-02-03
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Will be selected 100 patients who underwent cardiac surgery of coronary artery bypass graft electively in Dante Pazzanese Institute of Cardiology (IDPC).

Brief summary: Cardiac surgery has evolved considerably after the advent of cardiopulmonary bypass (CPB), a feature that allowed more precision and tranquility to the heart surgeon. But their influence on exacerbation of inflammatory response can unbalance the whole homeostasis so happens surgical trauma. The attenuation of the systemic inflammatory response in major surgeries like cardiac surgery for aortic aneurysm appears to represent an important advance in reducing morbidity and mortality of these patients. Some studies suggest that inhaled anesthetics such as sevoflurane appear to play an important role in this control, but the mechanism by which this happens is still unclear. This study has the primary purpose of analyzing from a clinical study sevoflurane inhalation anesthetic can change the inflammatory response induced by CPB, significantly reducing the release of inflammatory markers, especially elastase PMN.


Eligibility criteria: Inclusion Criteria:

* Age over 18 years
* Cardiac Surgery elective of coronary artery bypass graft with cardiopulmonary bypass (CPB)
* The informed consent signature savvy

Exclusion Criteria:

* Use of steroids or anti-inflammatory drugs routine
* Presence of asthma, COPD, autoimmune diseases
* Participation in other clinical studies
* Presence of decompensated heart failures, liver or kidney
* Combined elective surgery (ex .: aneurysm correction + CABG)
* Acute myocardial infarction in the last 30 days
* Unstable angina
* And obesity (BMI\> 50kg / m2)

Primary outcomes:
measure: Reduction of systemic inflammatory response
timeFrame: Through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Thiago Augusto Azevedo Maranhão Cardoso
Study officials:
References:
citation: Cardoso TAAM, Kunst G, Neto CN, de Ribamar Costa Junior J, Silva CGS, Bastos GM, Borges JB, Hirata MH. Effect of sevoflurane on the inflammatory response during cardiopulmonary bypass in cardiac surgery: the study protocol for a randomized controlled trial. Trials. 2021 Jan 6;22(1):25. doi: 10.1186/s13063-020-04809-x.
Clinical trial NCT02283645: Efficacy and Safety of 3% Minoxidil Lotion for Chest Hair Enhancement
Official title: Efficacy and Safety of 3% Minoxidil Lotion for Chest Hair Enhancement : A Randomized, Double-blind, Placebo-controlled Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Chest Hair Enhancement
Lead sponsor: Mae Fah Luang University Hospital
Sponsor class: OTHER
First posted: 2014-11-05
Enrollment: 64
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine efficacy and safety of 3% minoxidil lotion for chest hair enhancement.


Eligibility criteria: Inclusion Criteria:

* healthy male

Exclusion Criteria:

* serious underlying diseases
* history of chest/ hair treatment before 6 months
* history of surgery or trauma on chest area.
* history of minoxidil allergy

Primary outcomes:
measure: The change of global photographic assessment after 20 weeks from baseline
timeFrame: baseline and 20 weeks
Secondary outcomes:
measure: The change in number of hairs after 20 weeks from baseline
timeFrame: baseline and 20 weeks
Other outcomes:
measure: The change of hair diameter after 20 weeks from baseline
timeFrame: baseline and 20 weeks
measure: Number of participants with adverse events
timeFrame: baseline and 20 weeks
measure: Patient satisfaction by self-assessment questionnaires
timeFrame: baseline and 20 weeks
Locations:
Study officials:
References:
citation: Lee S, Tanglertsampan C, Tanchotikul M, Worapunpong N. Minoxidil 2% lotion for eyebrow enhancement: a randomized, double-blind, placebo-controlled, spilt-face comparative study. J Dermatol. 2014 Feb;41(2):149-52. doi: 10.1111/1346-8138.12275. Epub 2013 Nov 8.
citation: Suwanchatchai W, Tanglertsampan C, Pengsalae N, Makornwattana M. Efficacy and safety of bimatoprost 0.03% versus minoxidil 3% in enhancement of eyebrows: a randomized, double-blind, split-face comparative study. J Dermatol. 2012 Oct;39(10):865-6. doi: 10.1111/j.1346-8138.2012.01579.x. Epub 2012 May 17. No abstract available.
citation: Tanglertsampan C. Efficacy and safety of 3% minoxidil versus combined 3% minoxidil / 0.1% finasteride in male pattern hair loss: a randomized, double-blind, comparative study. J Med Assoc Thai. 2012 Oct;95(10):1312-6.
Clinical trial NCT04896645: Albuterol Integrated Adherence Monitoring in Children With Asthma
Official title: Albuterol Integrated Adherence Monitoring in Children With Asthma
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Asthma in Children
Lead sponsor: Children's Hospital Los Angeles
Sponsor class: OTHER
Collaborators: name: Teva Pharmaceuticals USA
First posted: 2021-05-21
Enrollment: 21
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The investigators propose to evaluate whether an integrated electronic adherence monitoring albuterol rescue inhaler can improve proper use in a mostly minority and inner-city population of children treated for asthma at the Children's Hospital of Los Angeles

Detailed description: This study is designed to (1) determine whether an integrated EAM albuterol rescue inhaler can increase proper use (2) determine if the monitoring capabilities of the device (flow rate, warnings) and/or increased proper use from having the device correlate with better outcomes. The investigators will also have patients perform at-home gamified spirometry (Aluna ©) to (3) determine if at-home spirometry can predict albuterol use or change outcomes.

Eligibility criteria: Inclusion Criteria:

* Patients 8 to \<19 years of age with a diagnosis of asthma as ICD-9 code 493 or ICD-10 code J45 seen in the allergy clinic at CHLA who have an albuterol rescue inhaler already prescribed and access to a personal smartphone will be eligible for recruitment.

Exclusion Criteria:

* Patients unable to use device, unable to use albuterol (i.e. must use levalbuterol) or Age \< 4 (ProAir® Digihaler only approved for Subjects 4 years and older). Patients with other chronic lung disease besides asthma or other significant comorbidities that could affect lung function/asthma (e.g. significant heart defects, immunodeficiency, cystic fibrosis, etc).

Primary outcomes:
measure: Asthma Outcomes
timeFrame: 3 months
measure: Asthma Adherence
timeFrame: 3 months
measure: Asthma Adherence
timeFrame: 3 months
measure: Asthma Outcomes
timeFrame: 3 months
measure: Asthma Outcomes
timeFrame: 3 months
measure: Albuterol Use
timeFrame: 3 months
Secondary outcomes:
measure: Spirometry
timeFrame: 3 months
measure: Lung Function
timeFrame: 3 months
measure: Asthma Quality of Life
timeFrame: 3 months
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Children's Hospital Los Angeles
state: California
Study officials:
affiliation: Children's Hospital Los Angeles
name: Neema Izadi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05486845: Special Lower Back Pillow Examination
Official title: The Effect of the Use of Lower Back Pillow.
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Low Back Pain
Keywords: LBP
special pillow
lower back pillow
Lead sponsor: Szeged University
Sponsor class: OTHER
First posted: 2022-08-04
Enrollment: 5000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SEQUENTIAL
Primary purpose: SCREENING

Brief summary: Low back pain is a significant, serious and widespread problem in our world today, both in terms of social and economic burdens. It should be emphasized that even the young adult age group is very often affected by non-specific, low back pain without proven pathoanatomical changes.

Detailed description: We plan to examine the use of a special lower back pillow and the time period of the sitting position. We would like to know how it helps to prevent and treat low back pain. We would like to know more about the people's pillow usage habits.

We are planning a questionnaire survey. We combine our own questions with validated, official questionnaires. Validated forms ask for an assessment of the extent of low back pain and the quality of experienced stress.

Eligibility criteria: Inclusion Criteria:

* in case of patients with low back pain: chronic pain
* in case of asymptomatic individuals: no symptomes

Exclusion Criteria:

* serious neurologycal symptomes
* serious scoliosis
* previous surgery which affected the local stabilizers
* serious pulmonar disease

Primary outcomes:
measure: MEDICAL HISTORY RECORD SHEET
timeFrame: 3 minutes
measure: THE QUEBEC BACK PAIN DISABILITY SCALE (QBPDS)
timeFrame: 2 minutes
measure: THE PERCEIVED STRESS SCALE (PSS)
timeFrame: 2 minutes
measure: VISUAL ANALOG SCALE
timeFrame: 1 minute
Secondary outcomes:
Other outcomes:
Locations:
city: Szeged
country: Hungary
facility: University of Szeged
state: Csongrád-Csanád
Study officials:
References:
Clinical trial NCT06276647: Improving Health Outcomes and Equity by Targeting Postpartum Mothers at Highest Risk
Official title: Improving Health Outcomes and Equity by Targeting Postpartum Mothers at Highest Risk: a Pilot Randomized Control Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Maternal Behavior
Postpartum Depression
Keywords: Postpartum
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
name: Columbia University
name: National Institute on Minority Health and Health Disparities (NIMHD)
First posted: 2024-02-26
Enrollment: 214
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The goal of this educational clinical trial is to identify Black women most at risk for poor outcomes following delivery, the problems they experience, and to create a system to improve quality of postpartum care for high-risk women. The main question\[s\] it aims to answer are:

* How can the investigators help postpartum Black people who have poor outcomes by decreasing the number of ED visits/readmissions for postpartum people within the first 30 days postpartum?
* How can the investigators increase the ability of participants to "obtain needed services" and ability for patients to see their provider when they need to, in the 30-day post discharge period as one of the main pathways of unnecessary ED visits?

Participants will be put into the study group or control group. The study group will receive a pamphlet postpartum with helpful information as well as a patient navigator who the participants will be able to reach out to their first 30 days postpartum.


Eligibility criteria: Inclusion Criteria:

* Postpartum patients who have delivered a baby at the Hospital of University of Pennsylvania
* Ages 18 or older
* Self-identify as Black (listed on chart)
* Speak English
* Able to read
* Other characteristics defined by our risk prediction model (algorithm)

Exclusion Criteria:

* Unable to provide informed consent
* Speaks a language other than English

Primary outcomes:
measure: Emergency Department (ED) Visits and Readmissions
timeFrame: 1-30 days postpartum
Secondary outcomes:
measure: Ability to Obtain Needed Services
timeFrame: 1-30 days postpartum
measure: Depressive Symptoms
timeFrame: 1 day-6 months postpartum
measure: Depressive Symptoms
timeFrame: 1 day-6 months postpartum
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Hospital of the University of Pennsylvania
state: Pennsylvania
Study officials:
References:
Clinical trial NCT01254747: Clinical Evaluation of an Investigational Soft Contact Lens
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myopia
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
First posted: 2010-12-07
Enrollment: 130
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this 4-week dispensing trial is to evaluate and compare an investigational soft contact lens worn on a daily disposable basis with three other soft contact lenses also worn on a daily disposable basis.


Eligibility criteria: Inclusion Criteria:

* Germany: Be of legal age.
* USA: Be of legal age or, if under legal age, have written consent of parent/guardian to participate and sign informed assent.
* Sign Informed Consent.
* Wear soft contact lenses for at least 3 months prior to the study.
* Wear soft contact lenses on a daily disposable basis, daily wear basis, or occasional extended wear basis.
* Other protocol-defined inclusion/exclusion criteria may apply.

Exclusion Criteria:

* Eye injury or surgery within twelve weeks prior to enrollment.
* Pre-existing ocular irritation that would preclude contact lens fitting.
* Currently enrolled in any clinical trial.
* Regularly wear contact lenses on an extended/overnight basis.
* Germany: pregnant or lactating.
* Other protocol-defined inclusion/exclusion criteria may apply.

Primary outcomes:
measure: Overall Comfort
timeFrame: 4 weeks
measure: Vision Quality During the Day
timeFrame: 4 weeks
measure: Overall Handling
timeFrame: 4 weeks
measure: Dryness Throughout the Day
timeFrame: 4 weeks
measure: Average Daily Wear Time
timeFrame: 4 weeks
Secondary outcomes:
measure: Lens Fit
timeFrame: 4 weeks
measure: Corrected Visual Acuity
timeFrame: 4 weeks
measure: Overall Satisfaction
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Duluth
country: United States
facility: CIBA VISION Research Clinic
state: Georgia
city: Grosswallstadt
country: Germany
facility: CIBA VISION Research Clinic
Study officials:
References:
Clinical trial NCT06807047: Effect of the EpiSchool-M App on Teachers' Epilepsy Knowledge, Attitudes, and Self-Management
Official title: The Effect of Epilepsy Management at School Mobile Health Application on Epilepsy Knowledge, Attitudes, and Self-Management of Teachers of Children With Intellectual Disability: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Epilepsy
Intellectual Disabilities
Teacher Training
Mobile Applications
Knowledge
Attitude
Self Management
Keywords: epilepsy
children with intellectual disabilities
Mobile Health Application
epilepsy knowledge
epilepsy attitude
epilepsy self management
Lead sponsor: Kafkas University
Sponsor class: OTHER
Collaborators: name: Akdeniz University
First posted: 2025-02-04
Enrollment: 90
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this study was to determine the effects of the training given to the teachers of children with intellectual disabilities with the "Epilepsy Management at School Mobile Health Application" and the "Digital Epilepsy Education Guide" on teachers' epilepsy knowledge, attitudes, and self management levels. This study was planned in a pretest, posttest design, follow-up, randomized controlled study. The sample of the study will consist of 90 teachers. Intervention-1 (Epilepsy Management at School Mobile Health Application, n=30), intervention-2 (Digital Epilepsy Education Guide, n=30) and control group (group without any intervention, n=30) will be included in the study. The data collection tools to be used in the research will be applied to all three groups at the same time intervals (T0: Just before the application phase of the research, T1: 15 days after the application, T2: one month after the application). The data will be collected using the Personal Information Form, the Knowledge and Attitudes Toward Epilepsy Among School Teachers Scale, and the Epilepsy Self-Management Scale for Teachers. Statistical Package for the Social Sciences (SPSS) 25.0 package program will be used in the analysis of the data.


Eligibility criteria: Inclusion Criteria:

* Working at special education schools affiliated with the Ministry of National Education in Antalya Province,
* Teachers of children with moderate to severe intellectual disabilities,
* Having a smartphone with internet access and either an Android or iOS operating system.

Exclusion Criteria:

* Teachers of children with hearing and visual impairments, without intellectual disabilities
* Teachers of children with mild intellectual disabilities

Primary outcomes:
measure: Knowledge And Attitudes Toward Epilepsy Among School Teachers Scale
timeFrame: 1.5 months
measure: Epilepsy Self-Management Scale for Teachers
timeFrame: 1.5 months
Secondary outcomes:
Other outcomes:
Locations:
city: Antalya
country: Turkey
facility: Akdeniz University
state: Konyaaltı
Study officials:
References: