louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02883920: Work-related Respiratory Symptoms in Champagne Vineyard Workers
Official title: Work-related Respiratory Symptoms in Champagne Vineyard Workers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Respiratory Symptoms
Lead sponsor: CHU de Reims
Sponsor class: OTHER
First posted: 2016-08-30
Enrollment: 307
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: workers of Champagne vineyard.

Brief summary: Work related asthma and rhinitis are frequent diseases with a significant morbidity and a social and economic impact. Farmers are highly exposed to various inhaled agents such as organic or inorganic dust, endotoxin, micro-organisms, pollen, mites, moulds, animal danders and pesticides, inducing rhinitis, asthma, chronic bronchitis, hypersensitivity pneumonitis and organic dust toxic syndrome. Work related respiratory symptoms are frequent in crop farmers. Allergic rhinitis and respiratory symptoms in fruit farmers are mainly related to pollen allergy, especially gramineae pollen. They can also be related to the use of pesticides or exposure to mites .

Detailed description: Aim of the study were :

to determine the prevalence of work related respiratory symptoms in workers of Champagne vineyard in France to analyze the relationships between respiratory symptoms, occupational exposure and sensitization profile in workers of Champagne vineyard in France

Eligibility criteria: Inclusion Criteria:

* workers of Champagne vineyard
* aged \> 18 years

Primary outcomes:
measure: Sensitization
timeFrame: Day 0
Secondary outcomes:
Other outcomes:
Locations:
city: Reims
country: France
facility: Chu de Reims
Study officials:
References:
citation: Perotin JM, Barbe C, Nguyen KL, Fontaine JF, Gabignon Y, Nardi J, Launois C, Lebargy F, Lavaud F, Deslee G. Work-related respiratory symptoms in Champagne vineyard workers. Eur Ann Allergy Clin Immunol. 2015 Sep;47(5):140-4.
Clinical trial NCT00827320: Bioequivalency Study of Levetiracetam 1g Tablets Under Fed Conditions
Official title: A Single Dose, 2-Period, 2-Treatment, 2-Way Crossover Bioequivalency Study of Levetiracetam 1g Tablets Under Fed Conditions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Seizures
Lead sponsor: West-Ward Pharmaceutical
Sponsor class: INDUSTRY
First posted: 2009-01-22
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The objective of this study was to prove the bioequivalence of Levetiracetam 1000 mg Tablets under fed conditions


Eligibility criteria: Inclusion Criteria:

* No clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening

Exclusion Criteria:

* Positive test for HIV, Hepatitis B, or Hepatitis C. Treatment with known enzyme altering drugs. History of allergic or adverse response to Levetiracetam or any comparable or similar product.

Primary outcomes:
measure: bioequivalence based on Cmax
timeFrame: 10 days
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: Novum Pharmaceutical Research Services
state: Texas
Study officials:
affiliation: Novum Pharmaceutical Research Services
name: Soran Hong, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06656520: Impact of Telehealth Care
Official title: Impact of Telehealth Care on Clinical Outcomes in Heart Failure Patients
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Telehealth Services
Telehealth
Keywords: Telehealth, heart failure, rehospitalization, mortality
Lead sponsor: National Taipei University of Nursing and Health Sciences
Sponsor class: OTHER
Collaborators: name: Mackay Memorial Hospital
name: National Taipei University of Nursing and Health Sciences
First posted: 2024-10-24
Enrollment: 0
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Inpatients diagnosed with heart failure were enrolled, with patients automatically selected daily by the electronic medical record system. A list of ward visits was obtained based on the first three digits of the International Classification of Diseases 10th edition diagnosis codes; the ICD-10 code I50 was applied for selection.

Brief summary: Heart failure is associated with high incidence and mortality rates, limited physical activity, decreased quality of life, and increased healthcare expenses. Implementing a Telehealth Care (TC) HF program could address these challenges while improving patient outcomes.

Detailed description: Telemonitoring for heart failure patients reduces all-cause and cardiovascular mortality by enabling early intervention during clinical deterioration, improving outcomes even for those recently discharged. Moreover, a reduction in the percentage of days lost due to unplanned cardiovascular hospital admissions is evident. Furthermore, the rapid expansion of telehealth care and telemedicine services during the COVID-19 pandemic optimized the management and care quality of heart failure patients through telemonitoring .

Eligibility criteria: Inclusion Criteria:

* Inpatients diagnosed with heart failure were enrolled, with patients automatically selected daily by the electronic medical record system. A list of ward visits was obtained based on the first three digits of the International Classification of Diseases 10th edition diagnosis codes; the ICD-10 code I50 was applied for selection.

Exclusion Criteria:

* Other diagnosis

Primary outcomes:
measure: mortality and rehospitalization rates
timeFrame: After discharge one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02194920: Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft Function
Official title: Arathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft Function
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Thyroid Goiter
Thyroid Carcinoma
Multinodular Goiter
Graves Diseases
Lead sponsor: University of Roma La Sapienza
Sponsor class: OTHER
First posted: 2014-07-18
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients receiving thyroid surgery with accidental removal or devascularization of normal parathyroid gland

Brief summary: The purpose of this study is to evaluate safety and effectiveness of normal parathyroid tissue reimplantation in forearm subcutaneous tissue in case of accidental removal of parathyroid gland during thyroid surgery.


Eligibility criteria: Inclusion Criteria:

* Patients affected by benign thyroid disease undergoing thyroidectomy

Primary outcomes:
measure: Assessment of parathyroid tissue graft function by selective (left or right) parathormone measurement by vein blood sample
timeFrame: up to 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Latina
country: Italy
facility: General Surgery Unit, ICOT Hospital
Study officials:
References:
Clinical trial NCT06391320: Obesity Queue Database
Official title: Obesity Queue Database
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Obesity
Lead sponsor: RenJi Hospital
Sponsor class: OTHER
First posted: 2024-04-30
Enrollment: 5000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with obesity, aged 18-75 years, who met the diagnostic criteria for simple obesity and did not participate in any drug clinical trials within 3 months prior to inclusion.

Brief summary: To establish an obesity specific disease cohort database and form a special disease cohort, so as to provide guarantee for carrying out high-quality real-world clinical research and clinical research.


Eligibility criteria: Inclusion Criteria:

* Patients aged 18-75 years with simple obesity. Simple obesity diagnosis criteria: meet one of the following conditions

  1. BMI≥25 kg/m2
  2. Waist circumference for male/female ≥90/80 cm
  3. Waist-to-hip ratio: 0.9 (male); 0.85 (female)

Exclusion Criteria:

* Patients aged 18-75 years with simple obesity. Simple obesity diagnosis criteria: meet one of the following conditions

  1. BMI≥25 kg/m2
  2. Waist circumference for male/female ≥90/80 cm
  3. Waist-to-hip ratio: 0.9 (male); 0.85 (female)

Primary outcomes:
measure: MRI-PDFF intraperitoneal fat content, fasting and postprandial blood glucose, insulin, C-peptide, glycated hemoglobin, body weight, waist circumference, hip circumference
timeFrame: 5 years
Secondary outcomes:
measure: Intestinal flora components, glucagon, gastrointestinal hormones GLP-1 and GIP, inflammatory immune indicators, etc
timeFrame: 5 years
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Renji Hospital, Shanghai Jiao Tong University, School of Medicine
Study officials:
References:
Clinical trial NCT03710720: Trauma Informed Prevention for Substance Use and Risky Sex
Official title: Mentorship and Research in HIV and Addiction Prevention Among Traumatized Youth
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Substance Use
HIV/AIDS
Keywords: Traumatic stress
substance use prevention
HIV prevention
adolescents
Lead sponsor: Medical University of South Carolina
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2018-10-18
Enrollment: 62
Sex: ALL
Minimum age (years): 12
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this research study is to determine the usefulness of the TIPS iPad app in the treatment of adolescent patients who qualify for Trauma Focused-Cognitive Behavioral Therapy (TF-CBT).

Detailed description: The primary goal of this study is to conduct a feasibility test of the delivery of the TIPS app during implementation of TF-CBT in comparison to TF-CBT as it is usually administered, as well as feasibility of methods that would be utilized in a larger scale evaluation of the toolkit. Clients will be randomly assigned to one of the two conditions, TF-CBT plus the TIPS app or TF-CBT as usual. Study duration is six months and includes four total assessments, which will be completed by hand. These assessments will occur over the 12-16 weeks of TF-CBT that clients would receive whether they choose to participate in the study or not. Participation in this study may broaden your child's treatment to target prevention of risk behaviors, but that cannot be guaranteed.

Eligibility criteria: Inclusion Criteria:

* Have experienced at least one traumatic event

Exclusion Criteria:

* Adolescents exhibiting psychotic symptoms
* Significant cognitive disability
* PDD
* Active suicidal or homicidal ideations
* Meets criteria for a DSM-5 moderate or severe substance use disorder

Primary outcomes:
measure: Risky Sexual Behaviors Scale
timeFrame: Pretreatment to 6 month follow-up
Secondary outcomes:
measure: Family Environment Scale
timeFrame: Pretreatment to 6 month follow-up
measure: Bad Friends Subscale of the Pittsburgh Youth Study
timeFrame: Pretreatment to 6 month follow-up
measure: Alabama Parenting Questionnaire
timeFrame: Pretreatment to 6 month follow-up
measure: UCLA PTSD Index DSM-V
timeFrame: Pretreatment to 6 month follow-up
measure: Children's Depression Inventory
timeFrame: Pretreatment to 6 month follow-up
measure: Timeline Follow Back (TLFM)-Form 90
timeFrame: Pretreatment to 6 month follow-up
measure: CRAFFT Screening Tool for Adolescent Substance Abuse
timeFrame: Pretreatment to 6 month follow-up
Other outcomes:
Locations:
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
Study officials:
affiliation: Medical University of South Carolina
name: Carla K Danielson, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03103620: Safety and Effectiveness Evaluation of COBRA PzF Coronary Stent System: A Post Marketing Observational Registry
Official title: Safety And Effectiveness Evaluation Of COBRA PzF™ Coronary Stent System: A French Observational Postmarketing Registry
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stable Angina
Unstable Angina
ACS - Acute Coronary Syndrome
STEMI
NSTEMI - Non-ST Segment Elevation MI
Myocardial Infarction
Lead sponsor: CeloNova BioSciences, Inc.
Sponsor class: INDUSTRY
Collaborators: name: AlpinARC
First posted: 2017-04-06
Enrollment: 1027
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients undergoing treatment of "de novo" lesions in native coronary vessels, saphenous vein graft and/or arterial bypass conduits with the COBRA PzF coronary stent system

Brief summary: A multi-center, prospective, consecutive enrolled, observational registry. The population being studied includes all patients undergoing treatment of "de novo" lesions in native coronary vessels, saphenous vein graft and/or arterial bypass conduits with the COBRA PzF coronary stent system. The registry will primarily assess the rate of MACE (cardiac death, myocardial infarction and clinically driven target lesion revascularization.


Eligibility criteria: Inclusion Criteria:

Patient has given oral consent to participate in the registry Patient is implanted with a COBRA PzF stent Target lesion(s) is/are "de novo"

Exclusion Criteria:

Pregnancy Age \<18 years Refusal or inability to give oral consent

Primary outcomes:
measure: MACE
timeFrame: 12 months
Secondary outcomes:
measure: Stent thrombosis
timeFrame: 12 months
measure: TVR and TLR
timeFrame: 12 months
measure: DAPT
timeFrame: 12 months
Other outcomes:
Locations:
city: Aix
country: France
facility: Clinique Axium
city: Annecy
country: France
facility: GCS Cardio
city: Antony
country: France
facility: SCM Angioscan
city: Aubagne
country: France
facility: Clinique La Casamance
city: Avignon
country: France
facility: Centre Hospitalier
city: Bayonne
country: France
facility: Clinique La Fourcade
city: Brive
country: France
facility: Centre Hospitalier
city: Clermont
country: France
facility: Clinique des Domes
city: Evecquemont
country: France
facility: Clinique Cardiologie
city: Grenoble
country: France
facility: Clinique Mutualiste
city: Haguenau
country: France
facility: Centre Hospitalier
city: Lyon
country: France
facility: Infirmerie Protestante
city: Montauban
country: France
facility: Clinique du Pont de Chaume
city: Montpellier
country: France
facility: Clinique du Millenaire
city: Pau
country: France
facility: Centre Hospitalier
city: Pessac
country: France
facility: Clinique St-Martin
city: Reims
country: France
facility: Polyclinique de Courlancy
city: Rouen
country: France
facility: Clinique St Hilaire
Study officials:
affiliation: Clinique Axium
name: Luc Maillard, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01399320: Ghnnam Excision Technique for Pilonidal Sinus
Official title: Ghnnam Excision Technique for Pilonidal Sinus
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Pilonidal Sinus
Surgical Wound
Dressing by Cyanoacrylate
Keywords: Pilonidal disease
Excision
cyanoacrylate
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2011-07-21
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Pilonidal disease is a common disorder of the sacrococcygeal region. It comprises a variety of problems, including infection/abscess and the development of a chronic sinus cavity.here we try a minimmally invasive method for managing such condition

Detailed description: Pilonidal disease is a common disorder of the sacrococcygeal region. It comprises a variety of problems, including infection/abscess and the development of a chronic sinus cavity. Incidence varies across countries and races .The cause remains controversial. Both congenital and acquired causes have been postulated Excision with a simple lay-open or performing marsupialization both result in a midline wound that takes several weeks to heal and there is a significant recurrence rate because of the open portal for hair insertion.so here we apply a new minimally invasive excision with cyanoacrylate dressing

Eligibility criteria: Inclusion Criteria:

* any patient with pilonidal sinus

Exclusion Criteria:

* pilonidal abscess or sever acute inflammation

Primary outcomes:
measure: healing of the sinus
timeFrame: 1 month
Secondary outcomes:
measure: recurrence
timeFrame: 1 year
measure: wound infection
timeFrame: 3-6 months
measure: patient satisfaction
timeFrame: 3 months
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mansoura Faculty of Medicine
state: Dakahlia
Study officials:
affiliation: mansoura faculty of medicine general surgery department
name: wagih m ghnnam, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02990520: Prevalence of Malnutrition and/or Sarcopenia at Hospital Admission
Official title: Prevalence of Malnutrition and/or Sarcopenia at Hospital Admission
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Malnutrition
Sarcopenia
Lead sponsor: The University of Texas Medical Branch, Galveston
Sponsor class: OTHER
First posted: 2016-12-13
Enrollment: 190
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hospitalized older adults

Brief summary: The purpose of this study is to determine the prevalence of malnutrition and/or sarcopenia at admission to the hospital in older adults.

Detailed description: The primary outcome of this study is to determine the prevalence of malnutrition and/or sarcopenia at admission to the hospital in older adults. The secondary outcome is to assess the relationship between malnutrition/sarcopenia status and length of stay, comorbidity load, polypharmacy, and 30-day readmission.

Eligibility criteria: Inclusion Criteria:

* Admitted to the UTMB ACE unit
* Aged 65 years or older
* Able to consent to participate in study (alert and oriented x3)

Exclusion Criteria:

* Because this study aims to determine prevalence of malnutrition and/or sarcopenia at admission to the hospital, patients will be excluded if study measures are not able to be taken within 72 hours of admission.

Primary outcomes:
measure: Prevalence of Malnutrition
timeFrame: baseline
Secondary outcomes:
measure: Prevalence of sarcopenia
timeFrame: baseline
Other outcomes:
Locations:
city: Galveston
country: United States
facility: UTMB Hospitals
state: Texas
Study officials:
affiliation: UTMB
name: Elena Volpi, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01057420: Effect of Hyperoxemia on Platelet Function in Healthy Volunteers
Official title: Effect of Hyperoxemia on Platelet Function in Healthy Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Healthy Volunteers
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2010-01-27
Enrollment: 50
Sex: ALL
Minimum age (years): 25
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: Prospective, controlled, randomized crossover volunteer study to investigate the effect of hyperoxemia due to inhalation of oxygen (80% inspiratory fraction) via reservoir-face-mask on blood coagulation, especially platelet function, as measured by thrombelastography. According to results of basic animal and in vitro investigations, hyperoxemia may activate platelets by means of reactive oxygen species. This study aims at investigating a possible pro-coagulant effect of hyperoxemia in healthy volunteers. Additional studies on possible mechanisms are integrated.

* Trial with medical device


Eligibility criteria: Inclusion criteria:

* informed consent; no coagulation disorder or other illnesses;
* non-smoker;
* women: no pharmacological contraception, negative pregnancy test;
* 25-45 years old; no medication; no acute or chronic airway problems;
* for 24 hours before study: no extreme physical activity, no polyphenol-containing food (red wine, apples, cabbage, garlic);
* for 48 hours: no caffeine-containing drinks, no dark chocolate.

Exclusion criteria:

* Lack of one of the inclusion criteria;
* allergy or incompatibility to substances/materials applied in the study;
* very thin veins/arteries.

Primary outcomes:
measure: maximum amplitude in thrombelastography
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: Surgical Intensive Care Medicine
Study officials:
affiliation: Surgical Intensive Care Medicine, UniversitaetsSpital Zuerich
name: Johannes Wacker, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Surgical Intensive Care Medicine, UniversitaetsSpital Zurich
name: Reto Stocker, Prof., MD
role: STUDY_DIRECTOR
References: