Clinical trial NCT06717633: Comparison of Short-term Effects of Extracorporeal Shock Wave Therapy, Low-level Laser Therapy and Pulsed Electromagnetic Field Therapy in Knee Osteoarthritis
Official title: Comparison of Short-term Effects of Extracorporeal Shock Wave Therapy, Low-level Laser Therapy and Pulsed Electromagnetic Field Therapy in Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Knee Osteoarthritis
Keywords: knee osteoarthritis
Lead sponsor: Istanbul Medeniyet University
Sponsor class: OTHER
First posted: 2024-12-05
Enrollment: 120
Sex: ALL
Minimum age (years): 40
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: 120 patients with Kellgren-Lawrence grade 2-3 knee osteoarthritis will be randomized into four groups: Control group, Extracorporeal shock wave therapy (ESWT) (once a week for 3 sessions), Low-level laser therapy (LLLT) (twice a week for 8 sessions), and Pulsed electromagnetic field therapy (PEMF) (twice a week for 8 sessions), with 30 patients in each group. All participants will be instructed in a daily exercise program, including knee joint range of motion, stretching, and strengthening exercises (3×10 repetitions). Outcome measures, including the Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Short Form-36 (SF-36), and Timed Up \& Go (TUG) test, will be assessed at baseline after treatment and at 3rd month.


Eligibility criteria: Inclusion Criteria:

* experiencing knee pain persisting for more than 6 months, radiological assessment confirming grade 2 and grade 3 knee osteoarthritis based on the Kellgren-Lawrence system
* no history of physical therapy or regular use of non-steroidal anti-inflammatory drugs (NSAIDs) within the last 6 months,
* absence of any pathology other than osteoarthritis that could cause knee pain,
* no lumbar spine or hip pathology that could refer pain to the knee,
* free from any conditions that would prevent participation in exercise or physical therapy
* willing to regularly participate the treatment programs were included in the study.

Exclusion Criteria:

* presence of a condition that impairs ambulation,
* a documented history of spinal stenosis,
* evidence of a neurological disorder based on medical history or physical examination,
* the existence of an inflammatory or metabolic disorder that could lead to secondary osteoarthritis,
* administration of intra-articular knee injections within the past year,
* use of NSAIDs, paracetamol or topical agents within the preceding week,
* a prior history of surgical intervention involving the knee joint.

Primary outcomes:
measure: Visual Analogue Scale (VAS)
timeFrame: baseline after treatment and at 3rd month
measure: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
timeFrame: baseline after treatment and at 3rd month
measure: Short Form-36 (SF-36)
timeFrame: baseline after treatment and at 3rd month
measure: Timed Up & Go Test (TUG)
timeFrame: baseline after treatment and at 3rd month
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Medeniyet University Goztepe Prof Dr Suleyman Yalcin City Hospital
state: None Selected
Study officials:
References: