Clinical trial NCT06930222: The Investigation of Predicting Mortality and Morbidity in Patients Admitted to Intensive Care Unit With Thoracic Trauma Using Selected Biomarkers and Parameters
Official title: The Investigation of Predicting Mortality and Morbidity in Patients Admitted to Intensive Care Unit With Thoracic Trauma Using Selected Biomarkers and Parameters
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Thorax Traumas
Keywords: thorax trauma
ROX index
Surfactant-d
Lead sponsor: Suleyman Demirel University
Sponsor class: OTHER
First posted: 2025-04-16
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with thoracic trauma admitted to icu

Brief summary: This prospective study aimed to predict morbidity and mortality after thoracic trauma in intensive care unit evaluated clinical and biochemical data of 50 intensive care unit patients. The research examined demographic factors such as gender, age, and smoking status, trauma scoring systems like ISS and RTS as well as biomarkers such as Surfactant-d and oxygenation parameters including the ROX index, PaO₂/FiO₂ ratio and FiO₂.


Eligibility criteria: Inclusion Criteria:

* Patients with thoracic trauma between the ages of 18-85
* Patients who have been monitored in intensive care for at least 1 week

Exclusion Criteria:

* Being outside the age range of 18-85
* Pregnant patients
* Patients whose intensive care follow-up lasted less than 1 week
* Patients who do not want to be included in the study
* Patients with a lung malignancy diagnosis before admission

Primary outcomes:
measure: Mortality Prediction Using ROX Index in Thoracic Trauma Patients
timeFrame: Measurements taken on day 1, day 3, and day 7 of hospitalization, following ICU admission.
measure: Mortality Prediction Using SP-D Levels in Thoracic Trauma Patients
timeFrame: Measurements taken on day 1, day 3, and day 7 of hospitalization, following ICU admission.
Secondary outcomes:
measure: Predictive Value of APACHE II Score in Mortality
timeFrame: Measurements taken on day 1, day 3, and day 7 of hospitalization.
measure: Predictive Value of SOFA Score in Mortality
timeFrame: Measurements taken on day 1, day 3, and day 7 of hospitalization.
measure: Predictive Value of TRISS Score in Mortality
timeFrame: Measurements taken on day 1, day 3, and day 7 of hospitalization.
measure: Predictive Value of RTS Score in Mortality
timeFrame: Measurements taken on day 1, day 3, and day 7 of hospitalization.
measure: CRP Levels and Mortality Prediction
timeFrame: Measurements taken on day 1, day 3, and day 7 of hospitalization.
measure: Procalcitonin Levels and Mortality Prediction
timeFrame: Measurements taken on day 1, day 3, and day 7 of hospitalization.
Other outcomes:
measure: NEU/LYM Ratio and Mortality Correlation
timeFrame: Measurements taken on day 1, day 3, and day 7 of hospitalization.
measure: Glasgow Coma Scale (GCS) and Mortality Correlation
timeFrame: Measurements taken on day 1, day 3, and day 7 of hospitalization.
Locations:
city: Isparta
country: Turkey
facility: Suleyman Demirel University
Study officials:
affiliation: Suleyman Demirel University
name: pınar karabacak
role: STUDY_DIRECTOR
References:
citation: Determann RM, Royakkers AA, Haitsma JJ, Zhang H, Slutsky AS, Ranieri VM, Schultz MJ. Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients. BMC Pulm Med. 2010 Feb 16;10:6. doi: 10.1186/1471-2466-10-6.
citation: Baker JE, Millar DA, Heh V, Goodman MD, Pritts TA, Janowak CF. Does chest wall Organ Injury Scale (OIS) or Abbreviated Injury Scale (AIS) predict outcomes? An analysis of 16,000 consecutive rib fractures. Surgery. 2020 Jul;168(1):198-204. doi: 10.1016/j.surg.2020.04.032. Epub 2020 May 13.
citation: Lundin A, Akram SK, Berg L, Goransson KE, Enocson A. Thoracic injuries in trauma patients: epidemiology and its influence on mortality. Scand J Trauma Resusc Emerg Med. 2022 Dec 12;30(1):69. doi: 10.1186/s13049-022-01058-6.