Clinical trial NCT02681822: Multi-center Imaging Genetics Studies in China
Official title: Multi-center Imaging Genetics Studies in China
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Alzheimer Disease
Schizophrenia
Major Depressive Disorders
Keywords: Genome-wide association studies
Environmental factors
Behavioral Assessment
Pathway analysis
Lead sponsor: Tianjin Medical University General Hospital
Sponsor class: OTHER
Collaborators: name: Tianjin Medical University Cancer Institute and Hospital
name: Tianjin Medical University Second Hospital
name: Tianjin First Central Hospital
name: Pingjin Hospital,Logistics University of Chinese People's Armed Police Forces
name: School of Medical Imaging, Tianjin Medical University
name: Tianjin Huanhu Hospital
name: Beijing Hospital
name: Chinese PLA General Hospital
name: Beijing Tongren Hospital
name: Xuanwu Hospital, Beijing
name: Peking Union Medical College Hospital
name: Beijing Normal University
name: Chinese Academy of Sciences
name: The Second Hospital of Hebei Medical University
name: The First Affiliated Hospital of Shanxi Medical University
name: Inner Mongolia Medical College Hospital
name: The First Hospital of Jilin University
name: The Frist Hospital Of China Medical University
name: The First Affiliated Hospital of Dalian Medical University
name: RenJi Hospital
name: Huashan Hospital
name: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
name: Nanjing PLA General Hospital
name: The First Affiliated Hospital with Nanjing Medical University
name: Xuzhou Medical University
name: Second Affiliated Hospital, School of Medicine, Zhejiang University
name: First Affiliated Hospital of Wenzhou Medical University
name: The First Affiliated Hospital of Anhui Medical University
name: Shan dong Medical Imaging Research Institute
name: Qilu Hospital of Shandong University
name: Yantai Yuhuangding Hospital
name: Henan Provincial People's Hospital
name: The First Affiliated Hospital of Zhengzhou University
name: Tongji Hospital
name: Wuhan University
name: Xiangya Hospital of Central South University
name: Central South University
name: Guangdong Provincial People's Hospital
name: The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
name: South China Normal University、Hainan General Hospital
name: First Affiliated Hospital Xi'an Jiaotong University
name: Xijing Hospital
name: Tang-Du Hospital
name: LanZhou University
name: West China Hospital
name: Second Affiliated Hospital of Wenzhou Medical University
name: University of Electronic Science and Technology of China
name: First Affiliated Hospital of Chongqing Medical University
name: Southwest Hospital, China
name: The University of Science and Technology of China
name: Guangdong No.2 Provincial People's Hospital
First posted: 2016-02-12
Enrollment: 10000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Healthy young Chinese Han subjects age 18-30

Brief summary: To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.

Detailed description: The investigators plan to collect behavioral assessment and environmental factors data,peripheral blood sample, MRI brain images in more than 10,000 healthy young Chinese Han individuals in order to build the pathway from gene to high-level cognitive phenotypes.

Eligibility criteria: Inclusion Criteria:

* aged 18-30
* Chinese Han
* right-handed
* without history of neuropsychiatric disease
* no substance addiction
* smoking

Exclusion Criteria:

* younger or elder than 18-30 year-old
* other ethnics
* with history of neuropsychiatric disease
* with history of neuropsychiatric disease among first,second and third degree relatives

Primary outcomes:
measure: Brain structure and function measured by MRI scans
timeFrame: 2 years
Secondary outcomes:
measure: Childhood adversities as assessed by Childhood Trauma Questionnaire-Short Form (Chinese Version)
timeFrame: 2 years
Other outcomes:
Locations:
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
state: Tianjin
Study officials:
affiliation: Tianjin Medical University General Hospital
name: Chunshui Yu, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Braskie MN, Jahanshad N, Stein JL, Barysheva M, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011 May 4;31(18):6764-70. doi: 10.1523/JNEUROSCI.5794-10.2011.
citation: Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993 Aug 13;261(5123):921-3. doi: 10.1126/science.8346443.