Clinical trial NCT03427567: A Study to Evaluate Effectiveness of Sublobar Dissection in Patients With Non-small Cell Lung Cancer
Official title: A Multi-centre Real-world Non-interventional Observational Study to Evaluate Effectiveness of Sublobar Dissection in the Chinese Patients With Non-small Cell Lung Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Keywords: Chinese
real-world evidences
NSCLC
sublobar dissection
Lead sponsor: Tongji Hospital
Sponsor class: OTHER
Collaborators: name: LinkDoc Technology (Beijing) Co. Ltd.
First posted: 2018-02-09
Enrollment: 3902
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Chinese patients with pathological diagnosed non-small cell lung cancer who received sublobar dissection and lymphadenectomy

Brief summary: A study to evaluate effectiveness of sublobar dissection in patients with non-small cell lung cancer

Detailed description: This is a multi-centre real-world non-interventional observational study. The study data on patient demographic/tumor biological characteristics and clinical treatments were retrospectively collected to evaluate effectiveness of sublobar dissection in the Chinese patients with non-small cell lung cancer who received sublobar dissection.

Eligibility criteria: Inclusion Criteria:

* Patients \>= 18 years old;
* Patients who received sublobar dissection from 2014 to 2017 (segment dissection/wedge dissection/segment and wedge dissections);
* Patients who received selective or systematic lymphadenectomy;
* Pathologically diagnosed patients with non-small cell lung cancer;
* Pathological staging: I, II

Exclusion Criteria:

* Patients who received cancer treatments before surgeries (adjuvant therapies including chemotherapies, radiotherapies, target therapies);
* Patients who received late-phase or intolerant palliative lobectomy or compromise sublobar dissection;

Primary outcomes:
measure: Overall survival
timeFrame: 2014 - 2017
Secondary outcomes:
measure: Overall survivals in subgroups
timeFrame: 2014 - 2017
Other outcomes:
measure: Impact factors of overall survival
timeFrame: 2014 - 2017
measure: Death rates after surgeries
timeFrame: 2014 - 2017
measure: Impact factors of death rates after surgeries
timeFrame: 2014 - 2017
measure: Incidence of complications after surgeries
timeFrame: 2014 - 2017
Locations:
city: Beijing
country: China
facility: China-Japan Friendship Hospital
state: Beijing
city: Beijing
country: China
facility: China PLA General Hospital
state: Beijing
city: Zhengzhou
country: China
facility: Henan cancer hospital
state: Henan
city: Wuhan
country: China
facility: Tongji Hospital Affiliated to Huazhong Technology Hospital
state: Hubei
city: Nanjing
country: China
facility: Jiangsu cancer hospital
state: Jiangsu
city: Xi'an
country: China
facility: Xi'an Tangdu Hospital
state: Shaanxi
city: Shanghai
country: China
facility: Shanghai Chest Hospital
state: Shanghai
city: Chengdu
country: China
facility: Huaxi Hospital Affiliated to Sichuan University
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Chest Hospital
state: Tianjin
city: Hangzhou
country: China
facility: First Hospital Affiliated to Zhejiang University
state: Zhejiang
Study officials:
affiliation: Tongji Hospital Affiliated to Tongji Medical College Huazhong Technology University
name: Xiangning Fu, PhD
role: PRINCIPAL_INVESTIGATOR
References: