Clinical trial NCT06867016: Effects of Bidomain Cognitive and Aerobic Training on Cognitive Functioning in Mild Cognitive Impairment.
Official title: Effects of Bidomain Cognitive and Aerobic Training on Cognitive Functioning in Mild Cognitive Impairment.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Mild Cognitive Impairment
Keywords: Cognition
Old age
mild cognitive impairment
aerobic
cognitive training
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2025-03-10
Enrollment: 44
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study aims to assess the effects of Bidomain cognitive and aerobic training on both cognitive functioning and quality of life in individuals with mild cognitive impairment.

Detailed description: The proposed study addresses a notable gap in the literature regarding the comparison between combined cognitive-aerobic training and cognitive training alone in improving cognitive function for patients with mild cognitive impairment (MCI). While previous studies have demonstrated the positive effects of both training methods on cognitive function independently, there is currently no research directly comparing their effectiveness when used together. The study aims to provide evidence on which treatment regime-combined cognitive-aerobic training or cognitive training alone-offers better outcomes for MCI patients. Aerobic training is known to enhance brain structure and function by strengthening neuronal connections, largely due to increased levels of brain-derived neurotrophic factor (BDNF) and enhanced vascularization, which stimulates hippocampal growth. On the other hand, cognitive training improves global cerebral functional connectivity, particularly activating the prefrontal cortex, which leads to better cognitive performance. Combining these training modalities may yield greater benefits than focusing on just one, offering a cost-effective, accessible approach that could significantly improve the quality of life and daily functioning for individuals with MCI.

Eligibility criteria: Inclusion Criteria:

* Older adults 60 years \& above
* With normal vision and color perception
* Independent Individual capable of carrying out daily tasks
* Individuals scoring 21-25 on the Mini-Mental State Examination (MMSE)

Exclusion Criteria:

* Medication affecting the exercise capacity of individual
* Regular participation in aerobic training for the last six months
* Cardiovascular or other diseases that do not allow physical activity
* A diagnosed severe psychiatric disease (e.g., depression)
* Patients with cognitive impairment or other neurological impairments due to AD or dementia.

Primary outcomes:
measure: Mini-mental state examination (MMSE)
timeFrame: 8 weeks
measure: Short Cognitive Test (SKT)
timeFrame: 8 weeks
Secondary outcomes:
measure: World health observational quality of life-BREF-100
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Chakwal
country: Pakistan
facility: DHQ Chakwal
state: Punjab
Study officials:
affiliation: Riphah International University
name: Saliha Ashfaq, MS-NMPT*
role: PRINCIPAL_INVESTIGATOR
References: