louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02245386: Effects of Pregnancy and Childbirth on Pelvic Floor Morphology and Sexual Function in Egyptian Women
Official title: Effects of Pregnancy and Parturition on Pelvic Floor Morphology and Sexual Function in Egyptian Women.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pregnancy, Childbirth and Puerperal Disorders
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2014-09-19
Enrollment: 120
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: primiparae in early postpartum period (48 hours to72 hours). written consent was taken. easy communicable, reachable women for further requirements.

Brief summary: To evaluate levator ani muscle morphology following normal vaginal delivery and cesarean section (elective and emergent), using three-dimensional (3D) transperineal ultrasound, and to study the effect of mode of delivery on female sexual function.

Detailed description: 1. transperineal pelvic floor ultrasound applied for the submitted 120 women "primiparae" (40 women after normal vaginal delivery), (40 women after urgent cesarean section), (40 women after elective cesarean section), in early postpartum period (48 to 72) hours postpartum, to evaluate levator ani morphology.
2. answering of the validated female sexual function index (F.S.F.I) three months postpartum period for same cases submitted to ultrasound.

Eligibility criteria: Inclusion Criteria:

* primiparae in early postpartum period (48 hours to72 hours). written consent was taken. easy communicable, reachable women for further requirements.

Exclusion Criteria:

1. Refused consent.
2. Previous vaginal or cesarean delivery.
3. Severe mental illness.
4. Severe physical handicap or difficulties in communication.
5. Women without postpartum active sexual life or separate from their spouse.
6. Past history of sexual dysfunction.

Primary outcomes:
measure: Pelvic floor muscle strength as assessed by three/four dimensional translabial pelvic floor ultrasound
timeFrame: early postpartum period (48 to 72) hours postpartum
measure: Sexual function of pelvic floor as assessed by the validated female sexual function index
timeFrame: at 3 months after delivery
Secondary outcomes:
measure: Trauma or avulsion of levator ani muscle as assessed by three/four dimensional translabial pelvic floor ultrasound
timeFrame: 6 months after delivery.
measure: Sexual function as assessed by the validated female sexual function index
timeFrame: 3 months after delivery
Other outcomes:
Locations:
Study officials:
affiliation: Al-Azhar University
name: Muhamed Osman, Ms
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05899686: Effect of Location of Tetanic Stimuli on Photoplethysmogram Under General Anesthesia
Official title: Effect of Tetanic Stimuli on Photoplethysmogram During General Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stress Reaction
Keywords: photoplethysmography
stress response
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
First posted: 2023-06-12
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Each participant will receive three tetanic stimuli. They are applied to the same three anatomical locations in each subject, but the order at which they are delivered to these locations will be random.
Primary purpose: DIAGNOSTIC

Brief summary: The effect of the location of tetanic stimulus on photoplethysmography signals will be studied in patients under general anesthesia.

Detailed description: A 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations (Ulnar nerve, Facial nerve, Posterior Tibial nerve) in a random order in patients who are under general anesthesia. Tetanic stimuli are used routinely during general anesthesia to assess effectiveness of neuromuscular blockade. These tetanic stimuli are noxious stimuli that elicit a stress response which can be quantified using photoplethysmography. This study investigates if the magnitude of the tetanus induced stress response is dependent on the location of the tetanic stimulus as measured by photoplethysmography.

Eligibility criteria: Inclusion Criteria:

* Surgical patients
* Undergoing general anesthesia
* Able to consent in english
* 18 years of age or older

Exclusion Criteria:

* Under 18 years of age
* unable to consent in english
* receiving regional anesthesia

Primary outcomes:
measure: Tetanic Stimulus Induced Change in Photoplethysmography Light Transmission (in Analog to Digital Units as Measured Using a Pulse Oximeter) From Pre Stimulus Baseline
timeFrame: Maximum light transmission change from pre tetanic stimulus baseline within 60 seconds after the tetanic stimulus
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: University of California San Francisco
state: California
Study officials:
affiliation: University of California, San Francisco
name: Pekka Talke, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03358186: Investigation on the Surgical Treatment Effect of Periprosthetic Femur Fracture After Hip Arthroplasty
Official title: A Multi-center Study on Investigating the Surgical Treatment Effect of Periprosthetic Femur Fracture After Hip Arthroplasty
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Periprosthetic Fractures
Keywords: Periprosthetic Fractures
Arthroplasty
Surgical procedures
Lead sponsor: Peking University People's Hospital
Sponsor class: OTHER
First posted: 2017-11-30
Enrollment: 155
Sex: ALL
Minimum age (years): 55
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with surgically treated periprosthetic femur fracture after hip arthroplasty

Brief summary: To Investigate the Surgical Treatment effect of Periprosthetic Femur Fracture After Hip Arthroplasty

Detailed description: In the study，155 patients from multiple center with periprosthetic femur fracture after hip arthroplasty are planned to be recruited. All the patients are treated surgically according to Vancouver classification，and their fracture union，pain in fracture site and lower extremity length are evaluated at 6 months and 1 year postoperatively．Also Harris scores are used to assess hip function at the 2 time points.

Eligibility criteria: Inclusion Criteria:

patients with periprosthetic femur fracture after hip arthroplasty

Exclusion Criteria:

Severe complications after surgery

Primary outcomes:
measure: fracture union
timeFrame: 1 year after surgery
Secondary outcomes:
measure: hip function
timeFrame: 1 year after surgery
measure: pain in fracture site
timeFrame: 1 year after surgery
measure: lower extremity length
timeFrame: 1 year after surgery
Other outcomes:
Locations:
Study officials:
affiliation: Peking University People's Hospital
name: Peng Zhang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02748486: Efficacy of Metacognitive Training Single Modules: Jumping to Conclusions and To Empathize...
Official title: Efficacy of Metacognitive Training Single Modules: Jumping to Conclusions and To Empathize... Among Patients of Psychiatric Rehabilitation Ward With Diagnosis of Schizophrenia.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Schizophrenia
Psychotic Disorders
Keywords: schizophrenia
randomized controlled trial
metacognitive training
single sessions
Lead sponsor: University of Warsaw
Sponsor class: OTHER
Collaborators: name: Medical University of Warsaw
name: Institute of Psychiatry and Neurology, Warsaw
First posted: 2016-04-22
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether modules of Metacognitive Training: Jumping to Conclusions and To empathize... are effective in the treatment of patients with schizophrenia. Also it was investigated whether these modules have specific impact on cognitive biases severity.

Detailed description: Investigators employ randomized controlled trial design. Patients in ward were recruited for the study in three waves. In each wave patients were assessed pre-intervention, then randomly allocated in one of three groups: with modules of Metacognitive Training or control group. Then patients were assessed post-intervention.

Eligibility criteria: Inclusion Criteria:

* diagnosis of psychotic disorders
* informed consent

Exclusion Criteria:

* neurological disorders

Primary outcomes:
measure: Fish Task
timeFrame: up to 3h after intervention
measure: Reading the Mind in the Eyes Test
timeFrame: up to 3h after intervention
measure: Cognitive Biases Questionnaire for Psychosis
timeFrame: up to 3h after intervention
Secondary outcomes:
measure: Symptom Checklist 27 plus
timeFrame: up to 3h after intervention
measure: Paranoia Checklist
timeFrame: up to 3h after intervention
Other outcomes:
Locations:
Study officials:
affiliation: Medical University of Warsaw
name: Łukasz Gawęda, MD
role: STUDY_CHAIR
References:
citation: Kuncewicz D, Dragan M, Hardt J. [Validation of the Polish version of the symptom checklist-27-plus questionnaire]. Psychiatr Pol. 2014 Mar-Apr;48(2):345-58. Polish.
citation: Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I. The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry. 2001 Feb;42(2):241-51.
citation: Moritz S, Woodward TS. Jumping to conclusions in delusional and non-delusional schizophrenic patients. Br J Clin Psychol. 2005 Jun;44(Pt 2):193-207. doi: 10.1348/014466505X35678.
citation: Freeman D, Garety PA, Bebbington PE, Smith B, Rollinson R, Fowler D, Kuipers E, Ray K, Dunn G. Psychological investigation of the structure of paranoia in a non-clinical population. Br J Psychiatry. 2005 May;186:427-35. doi: 10.1192/bjp.186.5.427.
Clinical trial NCT06440486: Assessment of Probiotics on Inflammation and Metabolism in Type 2 Diabetes.
Official title: Based on a Randomized, Double-blind, Controlled Trial, Evaluate the Effects of Probiotics on Inflammation and Metabolism in Patients With Type 2 Diabetes Mellitus.
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Type 2 Diabetes
Lead sponsor: Wecare Probiotics Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2024-06-03
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This clinical study aims to explore the effects of probiotics on inflammatory and metabolic indicators in patients with type 2 diabetes. By assessing the potential of probiotics to modify these markers, the study seeks to identify an economical and effective strategy for the prevention and treatment of type 2 diabetes.


Eligibility criteria: Inclusion Criteria:

1. Signed an informed consent form before the study and has a thorough understanding of the content, process, and possible adverse reactions of the study;
2. Age 18 (inclusive) and above, gender not limited;
3. Diagnosed with type 2 diabetes mellitus;
4. Not diagnosed with cardiovascular, kidney, or any other diabetic complications.

Exclusion Criteria:

1. Age over 75 years old;
2. Use of exogenous insulin or patients with cardiovascular disease and other complications;
3. Patients who are currently using α-glucosidase inhibitors;
4. Patients who have a habit of taking probiotics or are currently taking probiotics;
5. Pregnant or lactating women;
6. Subjects deemed unsuitable for participation in this clinical study by the investigators due to other reasons.

Primary outcomes:
measure: Inflammatory markers
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Nanchong
country: China
facility: Nanchong Central Hospital
state: Sichuan
Study officials:
References:
Clinical trial NCT05721586: Self-assembling Peptide With Sodium Fluoride in Treating White Spot Lesionss in Primary Teeth
Official title: Effectiveness of Self-assembling Peptide (p11-4) in Conjunction With Fluoride Varnish in the Management of White Spot Lesions in Primary Teeth (Randomized Controlled Clinical Trial)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: White Spot Lesion
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2023-02-10
Enrollment: 24
Sex: ALL
Minimum age (years): 3
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Regenerative medicine-based approaches for caries treatment focus on biomimetic remineralization of initial carious lesions as a minimally invasive therapy using Self-Assembling Peptide P11-4 (CURODONTTM REPAIR) which enhances remineralization of white spot lesions (WSLs). The study aimed to assess clinically the effect of Self Assembling Peptide P11-4 (CURODONTTM REPAIR) + Fluoride varnish (DURAFLOR) versus a 5% fluoride varnish (DURAFLOR) on remineralization of enamel White Spot Lesions in primary teeth.


Eligibility criteria: Inclusion Criteria:

* children with high caries risk with the presence of at least one visible active WSL in primary teeth with ICDAS II score of 1, 2 or 3

Exclusion Criteria:

* Children with systemic diseases
* Teeth with cavitated lesion involving dentin and enamel defects

Primary outcomes:
measure: Change in DIAGNOdent readings
timeFrame: Baseline, 3 months, and 6 months
Secondary outcomes:
measure: Change in ICDAS II scores
timeFrame: Baseline, 3 months, and 6 months
measure: Change in Nyvad scores
timeFrame: Baseline, 3 months, and 6 months
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Alexandria Faculty of Dentistry
Study officials:
References:
Clinical trial NCT01903486: Assessing the Efficacy of Steroid Treatment of Achalasia
Official title: A Pilot Study Assessing the Efficacy of Steroids in the Treatment of Achalasia
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Achalasia
Keywords: Trouble swallowing
dysphagia
disorder of the esophagus
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2013-07-19
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Would systemic steroids be an effective treatment in early variants of achalasia?


Eligibility criteria: Inclusion criteria:

* Adults ages 18-90 with a diagnosis of achalasia confirmed by findings on esophageal manometry and barium esophagogram will be eligible for the study.
* Eckardt score6 greater or equal to 6 or 2 or greater for dysphagia and/or regurgitation
* Symptoms less than 2 years

Exclusion criteria:

* Medical conditions such as severe heart or lung disease that preclude safe performance of endoscopy and injection;
* Greater than mild esophageal dilation
* Type 1 achalasia as defined by the Chicago classification scheme7 and/or esophageal diameter \> 3cm;
* Prior treatment for achalasia
* Use of medications that might affect LES pressure such as anticholinergics or calcium channel antagonists
* Symptom duration greater than 2 years
* Inability to read due to: Blindness, cognitive dysfunction, or English language illiteracy
* Disorders which predispose to unreliable responses such as Schizophrenia, Alzheimer's disease or significant memory loss
* Pregnant and lactating females will be excluded as steroids are not thought safe for the fetus.

Primary outcomes:
measure: the proportion of patients with an Eckhart score ≥ 6 at 1 month
timeFrame: Baseline to 1 month
Secondary outcomes:
measure: proportion of patients with symptomatic improvement (Eckardt sore 6 or greater)
timeFrame: baseline to 1 year
Other outcomes:
Locations:
Study officials:
affiliation: Mayo Clinic
name: Karthik Ravi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02838186: Backwards Examination of the Right Colon: A Back-to-back Study
Official title: Diagnostic Yield of Scope Retroflexion in the Right Colon: A Prospective Cohort Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colon Neoplasms
Keywords: colonoscopy
right colon retroflexion
adenoma detection rate
feasibility
surveillance interval
Lead sponsor: Attikon Hospital
Sponsor class: OTHER
First posted: 2016-07-20
Enrollment: 674
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this study is to evaluate the examination of the proximal colon with the retroflexion colonoscopic technique in terms of feasibility and its possible additive contribution in the detection of important lesions, namely polyps and cancers.

Detailed description: The investigators prospectively examined the additional diagnostic yield of right colon examination with colonoscope retroflexion in consecutive, symptomatic and screening - surveillance patients. Right colon was examined in forward-view first and thereafter, retroflexion was performed to re-inspect it.

Eligibility criteria: Inclusion Criteria:

* patients undergoing elective colonoscopy in a Attikon University General Hospital.

Exclusion Criteria:

* patients aged \<18 and \>80 years;
* right colectomy;
* recent abdominalsurgery;
* multiple diverticula of the right colon;
* American Society of Anesthesiology (ASA) physical status classification grade IV;
* inflammatory bowel disease and polyposis syndromes.

Primary outcomes:
measure: number of additional identified polyps with right colon scope retroflexion
timeFrame: one week
Secondary outcomes:
measure: Change in colorectal cancer (CRC) surveillance intervals among screening-surveillance patients
timeFrame: one week
measure: Rate of retroflexion-related adverse events.
timeFrame: one week
Other outcomes:
Locations:
city: Haidari
country: Greece
facility: Attikon University General Hospital
state: Attica
Study officials:
affiliation: Hepatogastroenterology Unit, 2nd Department of Internal Medicine and Research Institute, Attikon University General Hospital, University of Athens, Greece
name: Konstantinos Triantafyllou, Prof
role: STUDY_DIRECTOR
References:
citation: van Rijn JC, Reitsma JB, Stoker J, Bossuyt PM, van Deventer SJ, Dekker E. Polyp miss rate determined by tandem colonoscopy: a systematic review. Am J Gastroenterol. 2006 Feb;101(2):343-50. doi: 10.1111/j.1572-0241.2006.00390.x.
citation: Vemulapalli KC, Rex DK. Evolving techniques in colonoscopy. Curr Opin Gastroenterol. 2011 Sep;27(5):430-8. doi: 10.1097/MOG.0b013e328349cfc0.
Clinical trial NCT04340986: Cohort of Patients With Hepatocellular Carcinoma or Cholangiocarcinoma
Official title: Cohort Study of Patients With Primary Hepatocellular Carcinoma or Cholangiocarcinoma
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cholangiocarcinoma
Hepatocellular Carcinoma
Keywords: hepatocellular carcinoma
cholangiocarcinoma
cohort
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2020-04-10
Enrollment: 1250
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients with hepatocellular carcinoma or cholangiocarcinoma treated in Saint-Antoine hospital

Brief summary: The main objective is to describe the evolution of patients treated for a primary malignant hepatobiliary tumor (hepatocellular carcinoma or cholangiocarcinoma) over the long course.

Detailed description: The collection of data from patients with CHC and cholangiocarcinomas who are cancers with poor prognosis is a major challenge to improve patients'care (diagnosis, prognosis); facilitate the search for new therapeutic targets and the follow-up of clinical studies; and develop personalized treatments.

Eligibility criteria: Inclusion Criteria:

Inclusion Criteria :

* Age ≥ 18 years olds
* Medical care in Nephrology department since 2015

Cholangiocarcinoma:

- Histologically and cytologically documented cholangiocarcinoma, regardless of the stage of the disease

Hepatocellular carcinoma:

* Hepatocellular carcinoma at any stage of the disease, presenting the diagnostic criteria according to the diagnostic criteria of Barcelona : Tumor of more than 1 cm, developed on cirrhosis liver with arterial phase hyperenhancement and washout in the portal venous or delayed phases on CT and MRI
* Hepatocellular histologically documented

Exclusion Criteria:

- Lack of patient non-opposition

Primary outcomes:
measure: Overall survival
timeFrame: 5 years
Secondary outcomes:
measure: Overall survival
timeFrame: 5 years
measure: Disease free survival
timeFrame: 2 and 5 years
measure: Progression time under chemotherapy
timeFrame: Time of progression under chemotherapy up to 5 years
Other outcomes:
Locations:
city: Paris
country: France
facility: Serviec hépatologie-Hôpital Saint Antoine
Study officials:
affiliation: AssistancePublique-Hôpitaux de Paris
name: Marie LEQUOY, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01972386: EBUS/Spectrum Analysis
Official title: Spectrum Image Analysis of Lymph Nodes During Endobronchial Ultrasound-Guided (EBUS) Transbronchial Needle Aspiration (TBNA) in Patients With Lung Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Cancer
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
First posted: 2013-10-30
Enrollment: 122
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with lung cancer or suspected lung cancer who undergo EBUS TBNA for lymph node staging.

Brief summary: To evaluate the clinical benefit of spectrum analysis of endobronchial ultrasound images of lymph nodes during EBUS TBNA for lymph node staging in patients with lung cancer.


Eligibility criteria: Inclusion Criteria:

* Ages 18 years or older
* Patients with known or suspected lung cancer who require EBUS-TBNA for lymph node staging

Exclusion Criteria:

* Patients who are deemed on clinical grounds not to be medically fit for a bronchoscopy
* Inability to give informed consent
* Patients who are pregnant

Primary outcomes:
measure: Lymph Node Staging
timeFrame: Pathology report will be completed as soon as possible after the procedure. (Within one year)
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: University Health Network
state: Ontario
Study officials:
References: