Clinical trial NCT04941339: A Study of MRG002 in the Treatment of Patients With HER2-positive Advanced Solid Tumors
Official title: A Phase I, Open-label, Multi-center, First in Human, Dose Escalation and Expansion Study to Assess the Safety, Tolerability, Efficacy and Pharmacokinetics of MRG002 in Patients With HER2 Positive Advanced Solid Tumors
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Advanced Solid Tumor
Keywords: MRG002
Antibody Drug Conjugate (ADC)
HER2
Solid Tumors
Lead sponsor: Shanghai Miracogen Inc.
Sponsor class: INDUSTRY
First posted: 2021-06-28
Enrollment: 74
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The objective of this study is to assess the safety, efficacy, pharmacokinetics, and immunogenicity of MRG002 in patients with HER2-positive advanced solid tumors.

Detailed description: This study consists of two parts. Phase Ia is a dose escalation study to determine the maximum tolerated dose (MTD) and recommended phase II dose (RP2D) of MRG002. Phase Ib is a dose expansion study to further assess the efficacy and safety of MRG002 at confirmed RP2D.

Eligibility criteria: Inclusion Criteria:

1. Understands and provides written informed consent and willing to follow the requirements specified in protocol;
2. Both genders;
3. Aged 18 to 75 (including 18 and 75);
4. Expected survival time ≥ 12 weeks;
5. Patients with histologically and/or cytologically confirmed HER2-positive solid tumors who have failed standard therapy or for whom no standard therapy exists or for whom standard therapy is not appropriate at current stage;
6. Patients must have at least one evaluable lesion (Phase Ia) or measurable lesion (Phase Ib) according to the Response Evaluation Criteria in Solid Tumors (RECIST 1.1);
7. The score of ECOG for performance status is 0 or 1;
8. Prior anti-tumor treatment-related AEs (NCI CTCAE v5.0 Criteria) have recovered to ≤ Grade 1 (except alopecia);
9. No severe cardiac dysfunction with left ventricular ejection fraction (LVEF) ≥ 50%;
10. Organ functions must meet the basic requirements;
11. Coagulation function must meet the basic requirements;
12. Cumulative anthracycline dose ≤ 360 mg/m2 doxorubicin or its equivalent, 720 mg/m2 epirubicin.

Exclusion Criteria:

1. Received radiotherapy, chemotherapy, biotherapy, immunotherapy, or other anti-tumor drugs within 3 weeks prior to the first dose of MRG002 treatment;
2. History of severe cardiac disease;
3. Clinically significant abnormalities in rhythm, conduction, and resting ECG morphology;
4. Patients with poorly controlled hypertension or clinically significant vascular disease;
5. History of moderate to severe dyspnea at rest due to advanced cancer or their complications, severe primary lung disease, or current need of continuous oxygen therapy, or any history of interstitial lung disease (ILD) or pneumonitis;
6. Nausea and vomiting of any kind difficult to control, or chronic gastrointestinal disease;
7. Patients with symptoms of central nervous system or brain metastasis or received treatment for central nervous system or brain metastasis within 3 months prior to the first dose of MRG002 treatment;
8. Major surgery not fully recovery within 4 months prior to the first dose of MRG002 treatment;
9. History of hypersensitivity to any component of MRG002 or history of hypersensitivity of ≥ Grade 3 to trastuzumab injection;
10. Evidence of active infection of hepatitis B or hepatitis C;
11. History of immunodeficiency, including human immunodeficiency virus (HIV) infection, or other immunodeficiency disease, or history of organ transplantation;
12. Any serious and/or uncontrolled disease or other condition that, considered by the investigator and sponsor, may compromise the patient's participation in this study;
13. Received systemic corticosteroids within 4 weeks prior to the first dose of MRG002 treatment;
14. Female patients with a positive serum pregnancy test or who are breast-feeding or who do not agree to take adequate contraceptive measures during the treatment and for 6 months after the last dose of study treatment.
15. Other conditions inappropriate for participation in this clinical trial, at the discretion of the investigator.

Primary outcomes:
measure: Maximum Tolerated Dose (MTD)
timeFrame: DLT will be evaluated during the first treatment cycle (Day 1-28)
measure: Recommended Phase II Dose (RP2D)
timeFrame: Baseline to study completion (up to 6 months)
measure: Adverse Events (AEs)
timeFrame: Baseline to 49 days after the last dose of study treatment
Secondary outcomes:
measure: Objective Response Rate (ORR)
timeFrame: Baseline to study completion (up to 6 months)
measure: Duration of Response (DoR)
timeFrame: Baseline to study completion (up to 6 months)
measure: Progression Free Survival (PFS)
timeFrame: Baseline to study completion (up to 6 months)
measure: Pharmacokinetics (PK) parameter of MRG002: Cmax
timeFrame: Baseline to 21 days after the last dose of study treatment
measure: Pharmacokinetics (PK) parameter of MRG002: Tmax
timeFrame: Baseline to 21 days after the last dose of study treatment
measure: Pharmacokinetics (PK) parameter of MRG002: t1/2
timeFrame: Baseline to 21 days after the last dose of study treatment
measure: Pharmacokinetics (PK) parameter of MRG002: AUClast
timeFrame: Baseline to 21 days after the last dose of study treatment
measure: Immunogenicity
timeFrame: Baseline to 21 days after the last dose of study treatment
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Oriental Hospital
state: Shanghai
Study officials:
affiliation: Shanghai Oriental Hospital
name: Jin Li, Doctor
role: PRINCIPAL_INVESTIGATOR
References: