louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00884039: Anecortave Acetate Injection to Treat Steroid-responsive Intraocular Pressure Increase in Cornea Transplant Patients
Official title: Compassionate Use of Anecortave Acetate: Clinical Protocol for the Treatment of Corticosteroid-induced Intraocular Pressure (IOP) Increases After Corneal Transplantation
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Transplant
Intraocular Pressure
Keywords: cornea
transplant
intraocular pressure
steroid response
Lead sponsor: Cornea Research Foundation of America
Sponsor class: OTHER
First posted: 2009-04-20
Enrollment: 7
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will investigate the use of anecortave acetate injection to reduce intraocular pressure (IOP) in corneal transplant recipients who are experiencing steroid-associated pressure control problems. Alternative methods of IOP control have been shown to entail serious risks. For example, reduction of topical steroids increases the risk of graft rejection, and use of glaucoma medications or glaucoma surgery increases the risk of graft failure. This study is designed to have sufficient power to detect whether a single injection can induce a clinically significant IOP reduction.


Eligibility criteria: Inclusion Criteria:

* at least 18 years of age
* corneal transplant recipient with intraocular pressure (IOP) greater than 24 mmHg and with relative increase in IOP of at least 10 mmHg over the pre-graft baseline

Exclusion Criteria:

* not pregnant or lactating
* intraocular surgery in the study eye within 30 days before enrolling in the study
* use of any investigational drug or treatment within 30 days before receipt of study medication
* clinical evidence of scleral thinning

Primary outcomes:
measure: Intraocular Pressure Within Normal Limits (<24 mm Hg)
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Indianapolis
country: United States
facility: Price Vision Group
state: Indiana
Study officials:
affiliation: Cornea Research Foundation of America
name: Francis W. Price, Jr., MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06913439: Fin Wax Bath Therapy in Patients With Post-traumatic Stiffness of Knee Joint: A Randomized Controlled Trial
Official title: Fin Wax Bath Therapy in Patients With Post-traumatic Stiffness of Knee Joint: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Stiffness; Sacroiliac
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2025-04-06
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Knee traumas termed as any injury or damage to the knee's joint which is caused by different factors like sports injury, accidents and by fall .Knee stiffness is a common complication of femoral and tibia fracture and injuries to the extensor mechanism of the knee.

Detailed description: There are many types of trauma of knee joint such as anterior cruciate ligament (ACL) tear, posterior cruciate ligament (PCL) tears, medial collateral ligament (MCL) tear, lateral collateral ligament (LCL) tear and meniscal tears etc. Post-traumatic knee stiffness is a commonest problem after knee injuries or surgical procedure. It affects significantly patient's quality of life and making daily living activities challenging. Paraffin wax bath therapy involves soaking targeted area in a warm paraffin wax bath pour hot liquid form wax on target area.The heat from the wax increase blood circulation in the affected areas. Mobilization with Movement (MWM) is a type manual therapy technique includes combination of joint mobilization with movement to improve joint mobility, decrease pain and improve functional ability. MWM play a role of application of joint mobilization and active movement simultaneously. The researcher employs a randomized controlled trial methodology.

Eligibility criteria: Inclusion Criteria:

* Age 18-40 years.
* Both Male and female
* Fracture of the unilateral knee joint and around the knee managed with conservative treatment only.
* Subjects with post-traumatic stiffness of knee joint having a minimum of 70º knee flexion.
* Able to walk independently or with minimal assistance.
* Administer patient in study after 12 weeks of knee injury.

Exclusion Criteria:

* deformity of hip and knee.
* Implant at fracture and around fracture site.
* Subject having polyarthritis, bleeding disorders, tumors, local infection, peripheral vascular disease, leg-length discrepancy of more than one-half inch.
* History of knee replacement or other knee surgeries within the last six months.
* Presence of neurological conditions (e.g., stroke, multiple sclerosis) affecting gait or knee mobility.
* Known allergy or intolerance to paraffin wax therapy or other study interventions."

Primary outcomes:
measure: VISUAL ANALOG SCALE (VAS)
timeFrame: 12 Months
measure: OSTEOARTHRITS INDEX (WOMAC)
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Shoukat ismail medical complex
state: Punjab
Study officials:
References:
Clinical trial NCT06245239: Perfusion Index in Assessment of Postoperative Pain in Children.
Official title: Using Perfusion Index in Assessment of Postoperative Pain in Children Undergoing Hypospadias Repair Surgery: an Observational Follow up Study.
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Postoperative Pain
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-02-07
Enrollment: 65
Sex: ALL
Minimum age (years): 1
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children aged\<3 years of both sexes undergoing hypospadias repair surgery.

Brief summary: The aim of this study will be to examine the validity of perfusion index in predicting pain and evaluation of its severity in the postoperative period.

Detailed description: \* Hypospadias repair is a common surgery that is accompanied with significant postoperative pain. The largest group of children usually undergo this type of surgery are infants and pre-verbal children who cannot verbally report pain, and their treatment depends typically on behavioral and observational tools. Although these tools are valid and reliable measures in assessment of pediatric pain, they are still hindered by their subjectivity, which consequently could result in inadequate pain treatment that in early childhood may lead to negative behavioral and neurophysiological sequalae.

That is why recent studies have focused on developing more objective measures to evaluate pain especially when self-report is not possible.

\* Changes in perfusion index(PI) caused by sympathetic stimulation refers to possible correlation between pain and PI which forms the basis of our study proposing that the PI is a non-invasive easy method that can be used in evaluating pain in infants

Eligibility criteria: Inclusion Criteria:

1. patients aged \<3 years
2. Sex:- both male and female.
3. ASA I-II
4. Informed written consent obtained from parents or guardians of all patients.
5. Undergoing hypospadias repair surgery

Exclusion Criteria:

1. Patients outside the selective age range
2. Parents or guardians refusing to enroll their child in the study.
3. ASA III or VI
4. Children with behavioral changes or physical developmental delay
5. Children treated with sedatives or anticonvulsants.

Primary outcomes:
measure: Detection of the validity of Perfusion index in predicting Postoperative pain assessed by FLACC score
timeFrame: The baseline preoperative Perfusion index., The FLACC score along with the corresponding Perfusion index readings, will be recorded postoperatively: upon arrival to the PACU and every 30 minutes for 2 hours, then at 6, 12, 18, 24 hours.
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Noha yahia Mohammed
state: Assuit Governorate
Study officials:
affiliation: lecturer of anesthesia, faculty of medicine, Assiut university, Egypt
name: Noha yahia Mohammed, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02995239: A Study to Compare the Pharmacokinetic Characteristics of CJ-12420
Official title: A Randomized, Open-label, Single Dose, Crossover Study to Compare the Pharmacokinetic Characteristics of CJ-12420 in Healthy Male Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Erosive Esophagitis
Lead sponsor: HK inno.N Corporation
Sponsor class: INDUSTRY
First posted: 2016-12-16
Enrollment: 12
Sex: MALE
Minimum age (years): 19
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: To compare the pharmacokinetics after administration of different formulation of CJ-12420

Detailed description: The purpose of this study is to compare the pharmacokinetics after a single dose administration of CJ-12420 formulation 1 and formulation 2.

Eligibility criteria: Inclusion Criteria:

* Healthy male aged 19 to 45 years at the screening
* Subject who is over 50kg with BMI between 19 kg/m2 to 28 kg/m2 (inclusive)
* Subject who fully understood after being informed detailed description of clinical trial, written informed consent voluntarily to observe the precautions.

Exclusion Criteria:

* Subject who fall under the criteria below in laboratory test.

  * AST, ALT, ALP, GGT, total bilirubin, BUN, creatinine \> UNL x 1.5
* Subject who with low blood pressure with clinical significance at screening test.

  * (systolic blood pressure is less than 90 mmHg or over 140 mmHg, and diastolic blood pressure is less than 50 mmHg or over 90 mmHg)
* Subject who has a medical history of symptomatic GERD, erosive esophagitis or duodenal ulcer, gastric ulcer, barrett's esophagus or zollinger-ellison syndrome.

Primary outcomes:
measure: Assessment of the AUClast
timeFrame: Up to 48 hours
Secondary outcomes:
measure: Assessment of the AUCinf
timeFrame: Up to 48 hours
measure: Tmax
timeFrame: Up to 48 hours
measure: t1/2
timeFrame: Up to 48 hours
measure: Vd/F
timeFrame: Up to 48 hours
Other outcomes:
Locations:
city: Chonju
country: Korea, Republic of
facility: Chonbuk National University Hospital
Study officials:
affiliation: Chonbuk university hospital
name: Min-Gul Kim, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05350839: Reliability and Validity of HHIRS General Quality of Life Questionnaire
Official title: Reliability and Validity of HHIRS General Quality of Life Questionnaire in Urdu Speaking Population of Pakistan
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Musculoskeletal Pain
Neurological Disorder
Keywords: Reliability
Validity
HHIRS-General-QOL
questionnaire
patient reported outcome measure
Lead sponsor: Helping Hand Institute of Rehabilitation Sciences
Sponsor class: OTHER
First posted: 2022-04-28
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: study population targeted will be the Urdu-speaking population with any neurological or musculoskeletal pain/ disorder impacting their quality of life.

Brief summary: Quality of life is conceded by copious musculoskeletal and neurogenic conditions which are evaluated by manifold questionnaires. These questionnaires are obtainable in English and many other languages but in Pakistan, these cannot be applied due to differences in languages, lifestyles, culture, and activities of daily living (ADL's). In relation to the culture of Pakistan, there are many accomplishments such as offer prayers and other domestic obligation which cannot be executed appropriately if any Musculoskeletal and neurogenic disorders are existing. All these disorders can be assessed appropriately by questionnaires previously accessible but not in a single tool.

Detailed description: HHIRS developed a general quality of life questionnaire in the Urdu language for the expediency of patients. Relation of the questionnaire with upper limb has been identified but there is no clear relation with other body regions. Consequently, the purpose of this research is to evaluate the validity and reliability of the HHIRS-General-QOL Questionnaire in the Urdu Speaking Population of Pakistan.

Eligibility criteria: Inclusion Criteria:

* participants able to read and write Urdu
* neurological disorders
* musculoskeletal pain
* systemic diseases

Exclusion Criteria:

* communication disorder
* cognitive disorder

Primary outcomes:
measure: validity of HHIRS general quality of life questionnaire
timeFrame: 2 months
measure: Reliability of HHIRS general quality of life questionnaire
timeFrame: 72 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Mansehra
country: Pakistan
facility: Helping hand Institute of Rehabilitation Sciences Trust
state: KPK
Study officials:
affiliation: HHIRS Trust
name: keramat Ullah Keramat
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05080439: Comparative Effects of Two Conservative Treatments in Teres Major in Handball Athletes With Shoulder Pain
Official title: Comparative Effects of Two Conservative Treatments in Teres Major in Handball Athletes With Shoulder Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Shoulder Pain
Dry Needling
Diacutaneous Fibrolysis
Athletic Injuries
Lead sponsor: Universidad de Zaragoza
Sponsor class: OTHER
First posted: 2021-10-15
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to investigate the effects of the dry needling technique and diacutaneous fibrolysis technique in teres major muscles on pain, range of motion, strength extensibility and muscular properties of the soft tissues of the shoulder in athletes with shoulder pain.


Eligibility criteria: Inclusion Criteria:

* Athletes with Shoulder pain
* Glenohumeral internal rotation deficit
* Presence of active MTrP in the teres major muscle

Exclusion Criteria:

* Previous surgery in the upper limb
* Previous physiotherapy treatments in the shoulder
* Dry needling contraindications
* Previous dry needling experience to mantain the blinding

Primary outcomes:
measure: muscle stiffness
timeFrame: baseline
measure: muscle stiffness
timeFrame: After treatment immediately "1 hour"
measure: muscle stiffness
timeFrame: After treatment, one week follow-up
Secondary outcomes:
measure: Pain intensity
timeFrame: Baseline
measure: Pain intensity
timeFrame: After treatment immediately "1 hour"
measure: Pain intensity
timeFrame: After treatment, "one week follow-up"
measure: Range of motion
timeFrame: Baseline
measure: Range of motion
timeFrame: After treatment immediately "1 hour"
measure: Range of motion
timeFrame: After treatment, "one week follow-up"
measure: Extensibility
timeFrame: Baseline
measure: Extensibility
timeFrame: After treatment immediately "1 hour"
measure: Extensibility
timeFrame: After treatment, "one week follow-up"
Other outcomes:
Locations:
city: Soria
country: Spain
facility: Sandra Jiménez Jiménez-del-Barrio
Study officials:
affiliation: University of Valladolid
name: Luis Ceballos Laita, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT02822339: Sun Protection Factor Assay
Official title: Sun Protection Factor (SPF) Assay: UVA Protection Factor Assay Minimal Persistent Pigment-Darkening Dose
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sunscreening Agents
Lead sponsor: Bayer
Sponsor class: INDUSTRY
First posted: 2016-07-04
Enrollment: 5
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To evaluate the Sun Protection Factor efficacy on human skin.


Eligibility criteria: Inclusion Criteria:

* Fitzpatrick Skin Type l, ll and/or lll for UVB testing. Fitzpatrick Skin Type ll, lll and/or lV for UVA testing.
* Male and female
* Aged between 18-70 years old.
* Good health as determined from the HRL SHF (Subject History Form)
* Signed and dated Informed Consent Form
* Signed and dated HIPAA (Health Insurance Portability and Accountability Act) form.
* An unambiguous MED (Minimal Erythema Dose) or MPPD (Minimal Persistent Pigment Darkening Dose)

Exclusion Criteria:

* Subjects on test at any other research laboratory or clinic.
* Known allergy or sensitivity to sunscreens, cosmetics and toiletries, topical drugs and/or ultraviolet light.
* Pre-existing dermatologic conditions which have been diagnoses by a medical professional (e.g. psoriasis, eczema, etc.) which would interfere with this study.
* Pre-existing other medical conditions (e.g. adult asthma. diabetes).
* Treatment with antihistamines or corticosteroids within one week prior to initiation of the test.
* Treatment with antibiotics within two weeks prior to initiation of the test.
* Chronic medication which could affect the results of the study.
* Known pregnant or nursing women.

Primary outcomes:
measure: Minimal Erythema Dose (MED)
timeFrame: Up to 15 minutes
measure: Minimal Persistent Pigment Darkening Dose (MPPD)
timeFrame: Up to 15 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Union
country: United States
state: New Jersey
Study officials:
References:
Clinical trial NCT06938139: Defining Benchmarks for Gastric Cancer Patients Underwent Minimal Invasive Gastrectomy
Official title: Defining Benchmarks for Gastric Cancer Patients Underwent Minimal Invasive Gastrectomy: A Multicentre Analysis
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Adenocarcinoma
Surgery, Laparoscopic
Lead sponsor: Fujian Medical University
Sponsor class: OTHER
First posted: 2025-04-22
Enrollment: 90000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with postoperative histologically confirmed gastric adenocarcinoma at stages T1-4a, N0/+, M0 and treated with robotic or laparoscopic gastrectomies with curative intent along with lymph node dissection between January 2009 and April 2024.

Brief summary: The Benchmark-MISGC study was a large-scale retrospective observational study launched by the China Gastric Cancer Surgical Union, aiming to establish the benchmarks of the short- and long-term outcomes for gastric cancer patients who underwent minimal invasive gastrectomy.


Eligibility criteria: Inclusion Criteria:

1. Patients with postoperative histologically confirmed gastric adenocarcinoma at stages T1-4a, N0/+, M0;
2. underwent robotic or laparoscopic gastrectomies with curative intent

Exclusion Criteria:

1. ASA class \> 3;
2. remnant gastric cancer;
3. concurrent/previous malignant disease;
4. Distant metastasis;
5. Palliative resection;
6. Abodominal exploration.

Primary outcomes:
measure: Benchmark values of overall complication
timeFrame: 30 days
Secondary outcomes:
measure: Benchmark values of Overall survival (OS)
timeFrame: 1-year, 2-year and 3-year
measure: Benchmark values of Disease-specific survival (DSS)
timeFrame: 1-year, 2-year, and 3-year
measure: benchmark value of the number of harvest lymph nodes
timeFrame: 1 month
measure: Benchmark values of Mortality rates
timeFrame: 30 days
measure: Benchmark values of the incidence of intraoperative complications
timeFrame: 1 days
measure: Benchmark values of Intraoperative blood loss
timeFrame: 1 day
measure: Benchmark values of operation time
timeFrame: 1 day
measure: Benchmark values of textbook Outcome
timeFrame: 30 days
Other outcomes:
Locations:
city: Fuzhou
country: China
facility: Fujian medical university union hospital
state: Fujian
Study officials:
References:
Clinical trial NCT02094339: Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty
Official title: Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Pain
Complications
Keywords: Local analgesia system
Ropivacaine
Analgesic efficacy after operation
Postoperative
Lead sponsor: Guangzhou General Hospital of Guangzhou Military Command
Sponsor class: OTHER
First posted: 2014-03-21
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. There are multimodal postoperative pain management after TKA, including intravenous opioids, epidural analgesia, peripheral nerve blocks or periarticular infiltration with local anesthetics. All of these treatments may lead to side effects such as nausea, headache, hypotension, urinary retention, partial motor block and infection of the knee. Therefore the investigators will compare three methods of postoperative analgesic after TKA by their efficiency and complication.


Eligibility criteria: Inclusion Criteria:

1. Patients of American Association of anesthetists（ASA）Grade 1、2 or 3
2. Aged between 18 and 85 years
3. Undergoing elective total knee replacement

Exclusion Criteria:

1. Mental illness can not match
2. Nerve block, epidural anesthesia contraindicated
3. People who have Slow-type arrhythmias
4. History of chronic headaches and long-term use of analgesic drugs
5. People who were postoperative consciousness, language or hearing impaired

Primary outcomes:
measure: pain
timeFrame: 72 hours postoperation
Secondary outcomes:
measure: sedation
timeFrame: 72 hours postoperation
measure: complication
timeFrame: 72 hours postoperation
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Guangzhou Military Region General Hospital, Department of Anesthesiology
state: Guangdong
Study officials:
References:
citation: Toftdahl K, Nikolajsen L, Haraldsted V, Madsen F, Tonnesen EK, Soballe K. Comparison of peri- and intraarticular analgesia with femoral nerve block after total knee arthroplasty: a randomized clinical trial. Acta Orthop. 2007 Apr;78(2):172-9. doi: 10.1080/17453670710013645.
citation: Serpell MG, Millar FA, Thomson MF. Comparison of lumbar plexus block versus conventional opioid analgesia after total knee replacement. Anaesthesia. 1991 Apr;46(4):275-7. doi: 10.1111/j.1365-2044.1991.tb11495.x.