louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05596604: "Awareness, Preconception, and Fear of Epidural Analgesia Among Childbearing Women in Saudi Arabia."
Official title: "Awareness, Preconception, and Fear of Epidural Analgesia Among Childbearing Women in Saudi Arabia."
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Assess Women Awareness and Fear About EDA for Labor
Keywords: Awareness, preconception, fear, epidural analgesia, labor pain
Lead sponsor: King Khalid University Hospital
Sponsor class: OTHER
Collaborators: name: King Saud University
First posted: 2022-10-27
Enrollment: 202
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 55
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: included pregnant women attending an obstetrical clinic for routine antenatal follow-up

Brief summary: The aim of our study is to measure the level of awareness, preconceptions, and level of fear regarding epidural analgesia among childbearing women in KKUH in Riyadh.

Detailed description: This research was designed as a hospital-based observational cross-sectional study conducted at King Khalid University Hospital, using a self-administered questionnaire based on previous research.22-24-26 approved by the Institutional Review Board at King Saud University, College of Medicine, Riyadh, Saudi Arabia on 08.August.2022 Ref. No. 22/0592/IRB. The sample included pregnant women attending an obstetrical clinic for routine antenatal follow-up, and the data collection was conducted during the month of August 2022. The questionnaire included five parts (sociodemographic, preconception, awareness, fear, and desirability). a total of 26 questions with multiple-choice answers. The sample size was determined using the Comrey and Lee criterion Comrey and Lee (1992) stated that a 200-sample size is acceptable. The questionnaire was completed by 202 participants who met the inclusion criteria that is being a pregnant woman and completing the survey, and the exclusion criteria were non-pregnant women and an incomplete survey. The data collectors made it clear to the participants that taking part in the study was completely optional, and the participants signed anonymous consent forms.

Eligibility criteria: Inclusion Criteria:

* pregnant woman
* completing the survey

Exclusion Criteria:

* non-pregnant women
* incomplete survey

Primary outcomes:
measure: Awareness
timeFrame: month
Secondary outcomes:
Other outcomes:
Locations:
city: Riyadh
country: Saudi Arabia
facility: King Khalid Medical City
Study officials:
References:
Clinical trial NCT00811304: Real-time Ultrasound Guided Labor Epidural Placement
Official title: Real-time Ultrasound Guided Labor Epidural Placement
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Epidural Anesthesia
Keywords: ultrasound
labor epidural
failed epidural
outcome
Epidural insertion under realtime ultrasound guidance
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
First posted: 2008-12-18
Enrollment: 0
Sex: FEMALE
Minimum age (years): 14
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All pregnant women in labor.

Brief summary: Specific Aim: The purpose of this study is to determine if labor epidural placement using real-time (concurrent) ultrasound guided placement is superior to the conventional "standard" epidural technique without the use of ultrasound at Magee-Womens Hospital.

Hypothesis: Ultrasound guided labor epidural placement in real-time will decrease the traditional epidural failure rate from 5% to 1%.


Eligibility criteria: Inclusion Criteria:

* All pregnant women of childbearing age (including children aged 14 years and above) who request epidural analgesia at Magee-Womens Hospital will be eligible to participate in the study.

Exclusion Criteria:

* Men will not be included.

Primary outcomes:
measure: Failed epidural placement rate
timeFrame: From admission untill delivery
Secondary outcomes:
measure: The incidence of post dural puncture headache.
timeFrame: From insertion of epidural to 48 hours
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: Magee-Womens Hospital
state: Pennsylvania
Study officials:
affiliation: University of Pittsburgh
name: Manuel C Vallejo, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01977404: Nutritional Evaluation of Patients With Congestive Heart Failure
Official title: Nutritional Evaluation of Patients With Congestive Heart Failure
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Congestive Heart Failure
Keywords: Congestive heart failure
Energy expenditure
Body composition
Caloric intake
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2013-11-06
Enrollment: 100
Sex: ALL
Minimum age (years): 40
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with congestive heart failure between the ages 40 to 90 years.

Brief summary: This study objective is to assess the nutritional status of Patients With Congestive Heart Failure.


Eligibility criteria: Inclusion Criteria:

* Congestive heart failure patients between tne ages 40 to 90,all stages of the disease.

Exclusion Criteria:

* non

Primary outcomes:
measure: Nutritional status
timeFrame: 1.5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Tel-Aviv
country: Israel
facility: Sourasky medical center (Ichilov)
Study officials:
affiliation: The Tel Aviv Sourasky medical center, Ichilov
name: Nachum Vaisman, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05187104: Treatment of Age-related Macular Degeneration Using Retinal Stem and Progenitor Cells
Official title: Treatment of Age-related Macular Degeneration Using Retinal Stem and Progenitor Cells
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Age-Related Macular Degeneration
Lead sponsor: Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Sponsor class: OTHER_GOV
Collaborators: name: Belarusian State Medical University
First posted: 2022-01-11
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Treatment of age-related macular degeneration using retinal stem and progenitor cells

Detailed description: The aim of the project is to develop a biomedical cell product based on retinal pigment epithelium cells for highly effective treatment age-related macular degeneration; to conduct the clinical trials of the biomedical cell product in the treatment of age-related macular degeneration.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of age-related macular degeneration
* The patient can read, understand, follow the examination procedures and complete, if necessary, the required documentation
* Written informed consent

Exclusion Criteria:

* The presence of any malignant tumor within the last 5 years
* Acute or chronic diseases in the stage of decompensation
* Chronic infectious diseases: HIV, viral hepatitis B, C, tuberculosis
* Patients who are pregnant, breastfeeding, or fertile patients who are not using adequate contraceptive methods
* Chronic and protracted mental disorders, all diseases with the presence of the syndrome of dependence on alcohol, drugs and psychoactive substances, any other condition that makes the patient unable to understand the nature, extent and possible consequences of the study or, in the opinion of the researcher, prevents the patient from observing and performing protocol
* Patients are unable or unwilling to give written informed consent and / or follow research procedures
* Any other medical condition that, in the opinion of the investigator, may be associated with an increased risk to the patient or may affect the outcome or evaluation of the study

Primary outcomes:
measure: Visual acuity
timeFrame: 1 month
measure: Visual acuity
timeFrame: 1 year
measure: Adverse effects associated with the therapy
timeFrame: 1 month
measure: Adverse effects associated with the therapy
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Minsk
country: Belarus
facility: Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Study officials:
affiliation: Belarusian State Medical University
name: Ludmila Marchenko, Prof
role: STUDY_DIRECTOR
affiliation: the Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
name: Zinaida Kvacheva, Dr
role: STUDY_DIRECTOR
References:
Clinical trial NCT04815304: Clinical Features of COVID-19 Patients
Official title: Clinical Features of Severe Acute Respiratory Syndrome Coronavirus 2 Patients Admitted to the Intensive Care Units of Academic Hospital of L'Aquila (Italy)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
Acute Respiratory Distress Syndrome
Ventilatory Failure
Lead sponsor: San Salvatore Hospital of L'Aquila
Sponsor class: OTHER
First posted: 2021-03-25
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The data were collected during the first and the second wave of epidemic in COVID-19 patients with acute respiratory distress syndrome

Brief summary: The data were retrospectively collected during the first and the second wave of epidemic in COVID-19 patients with Severe Acute Respiratory Syndrome Coronavirus 2, at the moment of intensive care unit admission and during the in intensive care unit staying.

Detailed description: At the moment of intensive care unit admission and during the in intensive care unit staying, the following data were collected: peripheral lymphocyte subsets were measured by multiple-color flow cytometry, chest computed tomography and ultrasonography scans, arterial blood gas parameters (pH, partial pressure of carbon dioxide, partial pressure of oxygen, concentration of hydrogen carbonate, base excess, and arterial oxygen saturation), and pain assessed by using numeric rating scale.

Eligibility criteria: Inclusion Criteria:

* COVID-19 patients
* Acute respiratory distress syndrome
* needing of ventilatory support

Exclusion Criteria:

* asymptomatic COVID-19 patients
* few symptoms
* mild symptoms
* without needing of ventilatory support

Primary outcomes:
measure: Peripheral lymphocyte subsets
timeFrame: Change from date of hospitalization until the date of hospital discharge or date of death from any cause, whichever came first, assessed at 60 weeks
Secondary outcomes:
measure: Chest computed tomography
timeFrame: From date of hospitalization until the date of hospital discharge or date of death from any cause, whichever came first, assessed every 10 days up to 60 weeks
measure: Chest ultrasonography
timeFrame: From date of hospitalization until the date of hospital discharge or date of death from any cause, whichever came first, assessed every day up to 60 weeks
measure: Pain assessment
timeFrame: From date of hospitalization until the date of hospital discharge or date of death from any cause, whichever came first, assessed every day up to 60 weeks
measure: Upper airway damages
timeFrame: From date of hospitalization until the date of hospital discharge or date of death from any cause, whichever came first, assessed every day up to 60 weeks
Other outcomes:
Locations:
city: L'Aquila
country: Italy
facility: San Salvatore Academic Hospital
Study officials:
affiliation: ASL 1 Avezzano Sulmona L'Aquila
name: Franco Marinangeli, MD
role: STUDY_CHAIR
References:
Clinical trial NCT03247504: Adherence to Opioids in Oncology Out Patients
Official title: Adherence to Opioids in Oncology Out Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cancer Out Patients With Opioids
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2017-08-11
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: cancer out patients with opioids treatment

Brief summary: Cancer pain is undertreated despite a good access to opioids in France. Although many factors are involved, the barriers related to the patient (and his family) are often reported .the reluctance of the patient or the family to take the prescribed medication is linked to misconceptions about the opioids , cultural barriers; or the lack of explanations provided by the physician. Some patients can have undiagnosed slight cognitive impairment .The situation is now more complicated as appear on the market the new form of opioids for the cancer breakthrough pain drug, adding one more opioid formulation in the prescription. The goal of the study is to measure the adherence to opioids in cancer out patients and the associated factors.


Eligibility criteria: Inclusion Criteria:

* Cancer out patients with opioids by mouth prescription
* Prescription than more than 8 days

Exclusion Criteria:

* Patient not at home, but in nursing home or other setting were the treatment are given by medical staff
* Patient unable to answer at the questionnaire
* Opoids given Intravenous or other way than mouth.

Primary outcomes:
measure: Rate of cancer out patients with a low adherence to the opioids treatment
timeFrame: One day
Secondary outcomes:
Other outcomes:
Locations:
city: Pierre-Bénite
country: France
facility: Centre de Soins Palliatifs Lyon-Sud
Study officials:
References:
Clinical trial NCT06575504: Ultrasonographical of Suprarenal Gland in High Risk Neonates
Official title: Ultrasonographical Study of Suprarenal Gland in High Risk Neonates
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Insuffeciency of the Suprarenal Gland
Keywords: Doppler Ultrasound
Suprarenal gland
high risk neonates
NICU
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2024-08-28
Enrollment: 105
Sex: ALL
Minimum age (years): 1
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: neonates with high risk illness

Brief summary: Observation study The aim is to study the suprarenal blood flow among high-risk neonates and its relation to the risk factors

Detailed description: Ultrasonographical study of the suprarenal gland in high risk newborn infants Al-Zhrraa University hospital Sample size 105 Inclusion criteria: 1- High-risk newborn 2- Need NICU admission Exclusion criteria: Cases with Major congenital anomalies and NEC Primary outcome: Abnormal suprarenal blood flow Informed consent will be obtained from all parents and mothers of the newborns enrolled in the study.

All cases will be subjected to - Full history taking: (prenatal -natal - postnatal). According to the routine admission sheet of NICU of Alzahraa University Hospital, Faculty of Medicine for girls, AL-Azhar University, Cairo, Egypt.

Through clinical examination (APGAR score -estimation of gestational age using modified Ballard score \&#34;Ballard, 1991\&#34; - body weight - severity of respiratory illness using Downs score and Silverman\&#39;s score).

Laboratory investigations:

* Blood gases.
* Serum electrolytes and blood glucose.
* CBC. CRP.
* Liver and kidney functions. Radiological evaluation: in the form of Abdominal and chest x-ray. Ultrasonographical studies were done for suprarenal gland blood flow. - Statistical Analysis, Data were collected, revised, coded, and entered into the statistical package for social science (SPSS)

Eligibility criteria: Inclusion Criteria:

* High risk neonates

Exclusion Criteria:

* congenital anomalies

Primary outcomes:
measure: Adrenocortical insufficiency
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of medicine for girls
state: Pediatrics/neonatology
Study officials:
References:
Clinical trial NCT01250704: Inherited Myokymia: A Clinical and Genetic Study of a Family
Official title: Inherited Myokymia: A Clinical and Genetic Study of a Family
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: A Study of Clinical and Genetic Mutations in a Family of Neuromyotonia, so Called Isaac's Syndrome
Keywords: Neuromyotonia, Isaac's syndrome; Peripheral nerve hyperexcitability; Myokymia; Potassium channelopathy
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2010-12-01
Enrollment: 18
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: We interview and examine the family members directly at our hospital and home visit or indirectly by telephone visit.

Brief summary: Neuromyotonia (NMT), so called Isaac's syndrome, is a rare disorder in which hyperexcitability of peripheral motor nerves leads to intermittent muscle contractions. It is characterized by muscle twitching at rest (visible myokymia), cramps, hyperhidrosis, paraesthesiae, mild muscle weakness. and impaired muscle relaxation, or pseudomyotonia. Electromyographic recording is a key diagnostic tool in detecting myokymia and neuromyotonia. Pathophysiology of neuromyotonia is claimed to be related immune disorder, autoimmune anti-voltage-gated potassium-channel antibodies and genetic mutation in potassium channel. KCNA1 (Kv1.1) mutation was mostly reported in a autosomal dominant trait. In the present study, we report a family affected with myokymia，worsening with elevated body temperature, febrile illness or spicy food. How the change in temperature influence clinical features of channelopathies is an interesting topic. Variant clinical severity of family members are recorded. The index patient has possible autoimmune mechanism involvement because of his clinical feature of myasthenia gravis with thymoma and hyperthyroidism. Further analyzing the genetic mutation in potassium channelopathy may provide researchers some pathophysiological insight into the Isaac's syndrome.


Eligibility criteria: Inclusion Criteria:

* The disease was initially diagnosed of Isaacs syndrome by two neurologist(Dr Tsai and Dr Yang). We will recruit family members of diseased patient and normal subjects for clinical, electromyographic and genetic studies.

Exclusion Criteria:

* none

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: China medical university hospital
city: Taichung
country: Taiwan
facility: China medical university hospital
Study officials:
affiliation: China Medical University Hospital
name: Yi-Ting Hsu, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03290404: Descriptive Assessment of Practice in Anaesthesia : Lidocaine 1% Adrenaline Under in Axillary Block Realization
Official title: Descriptive Assessment of Practice in Anaesthesia : Lidocaine 1% Adrenaline Under in Axillary Block Realization
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Axillary Block
Keywords: Axillary Block
LidocaÏne 1% adrenaliné
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2017-09-21
Enrollment: 292
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult operated for the upper limb under block axillaire

Brief summary: Axillary block is the good anesthetic technique for upper limb surgery without exceeding a certain total dose injected of Local Anesthetic (AL).

The maximal recommended dose of Lidocaine adrenaline in the upper limb is 500 mg. The use of ultrasound helps guiding the locoregional anesthesia, and allows to decrease the AL concentration, thus decreasing the risks.

No previous study estimated a concentration of lidocaine lower than 1,5 % to realize upper limb surgery by axillary block.

The literature overestimating probably the rate of failure of the locoregional anesthesia under ultrasound-guidance, we suggest to estimate the rate of failure of the axillary block ultrasound-guided with the lidocaine 1 % adrenaline for realizing upper limb surgery in standard practice.


Eligibility criteria: Inclusion Criteria:

* Patients operated for the upper limb under block axillaire
* Adult
* non-opposition

Exclusion Criteria:

* medical advice to realize axillary block
* medical advice to local anaesthetic
* Allergy
* Pregnant
* ASA 3 or more

Primary outcomes:
measure: Resort to an anesthesia for help in case of ineffectiveness of the block
timeFrame: Day 1
Secondary outcomes:
measure: Block depth
timeFrame: Day 1
Other outcomes:
measure: Time of Block
timeFrame: Day 1
measure: Total dose of Lidocaïne adrenaline used
timeFrame: Day 1
measure: Patient satisfaction
timeFrame: Day 1
Locations:
city: Brest
country: France
facility: Hôpital Instruction des Armées
city: Brest
country: France
facility: CHRU de Brest
city: Quimper
country: France
facility: Centre Hospitalier Intercommunal de Cornouaille
Study officials:
References:
Clinical trial NCT04264104: Effect of Nervous System Mobilization on Athletes' Performance
Official title: Effect of Nervous System Mobilization on Athletes' Performance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: Aveiro University
Sponsor class: OTHER
First posted: 2020-02-11
Enrollment: 52
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to compare the effects of two diferente doses of nervous system mobilization on athletes performance.

Detailed description: It is anticipated that 60 athletes will be randomly allocated to receive either 4x10 (n=30) or 8x10 (n=30) repetitions of neural mobilization .

Data on flexibility (knee extension test) and lower limb strength and motor control (hop tests and vertical jump test) will be collected at baseline and after the neural mobilization.

Statistical analysis will be performed using a mixed-methods ANOVA.

Eligibility criteria: Inclusion Criteria:

* Healthy athletes

Exclusion Criteria:

* Nerve damage
* Arthritis
* Tumors
* Vascular conditions
* Spinal cord injuries
* Any sistemic condition
* Surgery in the past 6 months
* Injury in the last 3 months
* A knee angle of \<10º

Primary outcomes:
measure: Single Leg Hop Test
timeFrame: Baseline
measure: Single Leg Hop Test
timeFrame: Up to 1 hour after baseline
measure: Crossover Test
timeFrame: Baseline
measure: Crossover Test
timeFrame: Up to 1 hour after baseline
Secondary outcomes:
measure: 6-meter Time Hop Test
timeFrame: Baseline
measure: 6-meter Time Hop Test
timeFrame: Up to 1 hour after baseline
measure: Vertical Jump test
timeFrame: Baseline
measure: Vertical Jump test
timeFrame: Up to 1 hour after baseline
measure: Knee extension test
timeFrame: Baseline
measure: Knee extension test
timeFrame: Up to 1 hour after baseline
Other outcomes:
Locations:
city: Aveiro
country: Portugal
facility: basketball teams at Aveiro region
Study officials:
affiliation: Aveiro University
name: Anabela Silva
role: PRINCIPAL_INVESTIGATOR
References: