Clinical trial NCT06907368: Analysis of the Functional Impact of Total Knee Arthroplasty Using Quantified Gait Analysis and Proprioceptive Evaluation
Official title: Analysis of the Functional Impact of Total Knee Arthroplasty Using Quantified Gait Analysis and Proprioceptive Evaluation. Prospective, Single-center, Open-label Study, Cohort Follow-up.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Total Knee Arthroplasty for Gonarthrosis
Keywords: Gonarthrosis
Proprioception
Functional recovery
Patient-reported Outcomes Measures (PROMs)
Quantitative Gait Analysis
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
Collaborators: name: University Grenoble Alps
First posted: 2025-04-02
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients who undergone total knee arthroplasty for gonarthrosis in Grenoble University Hospital

Brief summary: Total knee arthroplasty remains the gold standard in the management of disabling gonarthrosis. Improved functional results, increased availability of care and an ageing population have all contributed to the rise in total knee replacement surgery in Western countries. Surgical techniques have been steadily improving for several decades in terms of implant positioning and joint alignment. However, 10% of patients are dissatisfied with the clinical and functional results. The challenge is to understand why these patients remain dissatisfied despite these surgical advances. Our aim is to understand the functional impact of knee prosthesis through a quantified analysis of gait, the performance of certain tasks of daily living, and pre- and post-operative proprioceptive assessments. We will link these results with patient feedback to identify factors potentially responsible for poor postoperative outcomes.


Eligibility criteria: Inclusion Criteria:

* Adult patient
* Gonarthrosis on imaging with indication for total knee arthroplasty (TKA)
* Isolated gonarthrosis

Exclusion Criteria:

* Patient objecting to study participation
* Patient with an associated pathology causing balance and/or proprioceptive disorders (Parkinson's, stroke sequelae, etc.).
* Patients with a history of cognitive disorders, either confirmed or currently being assessed.
* IADL score below 3, indicating major dependence in daily life.
* Patients unable to walk without technical aids for 6 months.
* Patients unable to get up from a chair without armrests
* Parker score below 6
* Protected persons covered by articles L1121-5 to L1121-8 of the French Public Health Code

Primary outcomes:
measure: Post-operative functional recovery of patients who have undergone total knee arthroplasty for gonarthrosis by analyzing their locomotion ability
timeFrame: Preoperatively (PreOP) and 12 months postoperatively (PostOP12)
Secondary outcomes:
measure: Functional recovery by analyzing changes in gait variability
timeFrame: Preoperatively (PreOP) , 3 months postoperatively (PostOP3), 12 months postoperatively (PostOP3)
measure: Impact of total knee arthroplasty (TKA) on proprioception
timeFrame: Preoperatively (PreOP) , 3 months postoperatively (PostOP3), 12 months postoperatively (PostOP3)
measure: Functional recovery after TKA by analyzing changes in daily living tasks by SIT TO STAND test
timeFrame: Preoperatively (PreOP) , 3 months postoperatively (PostOP3), 12 months postoperatively (PostOP3)
measure: Functional recovery after TKA by analyzing changes in daily living tasks by STEP INITIATION test
timeFrame: Preoperatively (PreOP) , 3 months postoperatively (PostOP3), 12 months postoperatively (PostOP3)
measure: Functional recovery after TKA by analyzing changes in daily living tasks by OBSTACLE CLEARANCE test
timeFrame: Preoperatively (PreOP) , 3 months postoperatively (PostOP3), 12 months postoperatively (PostOP3)
measure: Evolution of Quality of Life
timeFrame: Preoperatively (PreOP) , 3 months postoperatively (PostOP3), 12 months postoperatively (PostOP3)
measure: Evolution of the patient's functional results assessed by the KSS questionnaire
timeFrame: Preoperatively (PreOP) , 3 months postoperatively (PostOP3), 12 months postoperatively (PostOP3)
measure: Evolution of the patient's functional results assessed by the SKV questionnaire
timeFrame: Preoperatively (PreOP) , 3 months postoperatively (PostOP3), 12 months postoperatively (PostOP3)
measure: Evolution of the patient's functional results assessed by the KOOS questionnaire
timeFrame: Preoperatively (PreOP) , 3 months postoperatively (PostOP3), 12 months postoperatively (PostOP3)
Other outcomes:
Locations:
city: Grenoble
country: France
facility: Grenoble University Hospital
Study officials:
References: