Clinical trial NCT06942845: Exploration of Risk Factors for Postoperative Cerebral Infarction in Lung Cancer Patients: a Retrospective Single-centre Study
Official title: Exploration of Risk Factors for Postoperative Cerebral Infarction in Lung Cancer Patients: a Retrospective Single-centre Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer, Non-Small Cell
Postoperative Cerebral Infarction
Lead sponsor: Shanghai Chest Hospital
Sponsor class: OTHER
First posted: 2025-04-24
Enrollment: 300
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1. patients with postoperative cerebral infarction in the hospital during the same period of time as the case group
2. hospitalised surgical patients in the same period as the control group.
3. patients who underwent pneumonectomy for lung nodules as the reason for surgery.

Brief summary: Lung cancer remains the world's leading cancer in terms of morbidity and mortality, with more than 20 million new cases and 9.7 million deaths annually. Despite improvements in surgical techniques and medical care, the number of elderly people undergoing surgery is gradually increasing, so there are an increasing number of complications following lung resection. Postoperative cerebral infarction is a relatively rare but devastating complication that places a heavy burden on patients and families. The incidence of postoperative cerebral infarction in patients after thoracic surgery has been reported to be 0.6-1.1%. There is a risk of postoperative cerebral infarction after lung cancer surgery, and the results of a few studies have shown that postoperative cerebral infarction is related to old age, male, hypertension, hyperlipidemia, and lobectomy factors, but the pathogenesis of the occurrence of cerebral infarction has not been clearly proved for the time being, and so these risk factors cannot be taken as the direct cause of cerebral infarction. Therefore, we need to further explore the factors leading to cerebral infarction after lung cancer surgery. If we can further prove that some of the risk factors are related to the causes of cerebral infarction after lung cancer surgery, we can make corresponding strategies in the perioperative period to improve the safety of surgery and reduce the incidence of cerebral infarction in the postoperative period.


Eligibility criteria: Inclusion Criteria:

Postoperative cerebral infarction

Exclusion Criteria:

No postoperative infarction

Primary outcomes:
measure: Analysing independent risk factors for cerebral infarction after pneumonectomy
timeFrame: 5min
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Chest Hospital
Study officials:
References:
citation: Nishizawa N, Okawara M, Mori M, Fujino Y, Matsuda S, Fushimi K, Tanaka F. Postoperative cerebral infarction risk is related to lobectomy site in lung cancer: a retrospective cohort study of nationwide data in Japan. BMJ Open Respir Res. 2022 Jul;9(1):e001327. doi: 10.1136/bmjresp-2022-001327.
citation: Matsumoto K, Sato S, Okumura M, Niwa H, Hida Y, Kaga K, Date H, Nakajima J, Usuda J, Suzuki M, Souma T, Tsuchida M, Miyata Y, Nagayasu T. Frequency of cerebral infarction after pulmonary resection: a multicenter, retrospective study in Japan. Surg Today. 2018 May;48(5):571-572. doi: 10.1007/s00595-017-1620-9. Epub 2018 Jan 11. No abstract available.
citation: Gao S, Zhou Y, Yang R, Du C, Wu Y. Risk factors for postoperative cerebral infarction in patients after lung resection: a single-center case-control study. J Thorac Dis. 2023 Feb 28;15(2):376-385. doi: 10.21037/jtd-22-1019. Epub 2023 Jan 16.
citation: Hattori A, Takamochi K, Kitamura Y, Matsunaga T, Suzuki K, Oh S, Suzuki K. Risk factor analysis of cerebral infarction and clinicopathological characteristics of left upper pulmonary vein stump thrombus after lobectomy. Gen Thorac Cardiovasc Surg. 2019 Feb;67(2):247-253. doi: 10.1007/s11748-018-1017-8. Epub 2018 Sep 24.
citation: Nojiri T, Inoue M, Takeuchi Y, Maeda H, Shintani Y, Sawabata N, Hamasaki T, Okumura M. Impact of cardiopulmonary complications of lung cancer surgery on long-term outcomes. Surg Today. 2015 Jun;45(6):740-5. doi: 10.1007/s00595-014-1032-z. Epub 2014 Sep 19.