louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06660836: Effect of Digitally Produced Custom Mouthguards on the Awareness and Sports Performance of Child and Adolescent Basketball Players
Official title: Effect of Digitally Produced Custom Mouthguards on the Awareness and Sports Performance of Child and Adolescent Basketball Players
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Sports Performance in Children
Keywords: mouthguard
digital workflow
sports performance
protective equipment
Lead sponsor: Akdeniz University
Sponsor class: OTHER
First posted: 2024-10-28
Enrollment: 80
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: CROSSOVER
Primary purpose: SCREENING

Brief summary: The aim of the study is to investigate the effects of custom mouthguards, prepared using digital workflow, on the sports performance of children and adolescents who play basketball, and to evaluate their views on the use of mouthguards.

Do digitally produced custom mouthguards have an effect on the sports performance of child and adolescent basketball players?

Will the awareness and opinions of child and adolescent basketball players regarding mouthguards be affected?

Participants will:

Undergo the Yo-Yo performance test both while using and not using mouthguards prepared with a digital workflow.


Eligibility criteria: Inclusion Criteria:

* Involved in basketball for at least one year,
* Amateur or semi-professional athletes,
* Possession of a health report confirming eligibility for high-activity sports,
* No severe skeletal or dental anomalies,
* Class I occlusion relationship,
* No or mild dental crowding issues,
* No severe nasal deviation that would interfere with sports,
* No prior use of any type of mouthguard,
* Training 4-5 days a week and actively competing in a basketball league.

Exclusion Criteria:

* Individuals with mouth breathing,
* Individuals with a history of adenoid vegetation or enlarged adenoids.

Primary outcomes:
measure: Effects of custom mouthguards on sports performance of child and adolescent basketball players
timeFrame: From enrollment to the end of performance tests, up to 20 weeks
Secondary outcomes:
measure: Knowledge, awareness, and views on mouthguards
timeFrame: Within 10 minutes after the performance test
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06716736: Socket Preservation After Surgical Extraction of Impacted Lower Third Molar
Official title: Socket Preservation Using Autogenous Particulate Dentin in Combination With Liquid Platelet-rich Fibrin Versus Bone Allografts and Collagen Cones After Surgical Extraction of Impacted Lower Third Molar
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Socket Preservation
Keywords: socket preservation
dentine graft
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2024-12-04
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this study will be to evaluate socket preservation using autogenous particulate dentin in combination with liquid platelet-rich fibrin versus bone allografts and collagen cone after surgical extraction of the horizontally impacted lower third molar

Detailed description: The aim of this study will be to evaluate socket preservation using autogenous particulate dentin in combination with liquid platelet-rich fibrin (sticky tooth) versus bone allografts and collagen cone after surgical extraction of the horizontally impacted lower third molar

Eligibility criteria: Inclusion Criteria:

1. Fresh extracted socket of horizontally impacted mandibular third molar
2. Co-operative patients willing to complete the follow-up periods.
3. Patients age from 18-35 years.
4. Good oral hygiene.

Exclusion Criteria:

1. Any pathological condition at the site of surgery.
2. Patients with systemic diseases that contra-indicate the surgical procedure such as uncontrolled diabetes mellitus, bleeding disorders, serious osseous disorders and mental disorders.
3. Smokers .
4. Pregnancy.

   -

Primary outcomes:
measure: bone resorption distal to second molar
timeFrame: 3 months after extraction
Secondary outcomes:
measure: bone density
timeFrame: 3 months after extraction
measure: edema
timeFrame: 4 days after extraction
measure: pain after surgical extraction
timeFrame: 4 days after extraction
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mansoura University
state: Eldakahlia
Study officials:
affiliation: mansoura uniersity
name: Wael M Ahmed, PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04784936: Identification of Stroke at the Emergency Medical Dispatch Center
Official title: Identification of Stroke at the Emergency Medical Dispatch Center
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stroke
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
First posted: 2021-03-05
Enrollment: 179
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who has called the emergency medical dispatch centre and also are diagnosed as stroke at Södersjukhuset during the study period.

Brief summary: A study to investigate how stroke is identified and whether FAST, face-arm-speech test, is used in the emergency medical dispatch centre in Stockholm. The study will also investigate when FAST is used, does it increase the identification of stroke? And if other factors can be identified as "markers" for more effective identification of stroke during the emergency call.

Detailed description: Transcribed alarm calls are read through and analyzed using a qualitative method. Meaningful units are identified, coded and categorized. A phenomenological analysis is also applied to a separate analysis.

Eligibility criteria: Inclusion Criteria:

* Patients who has called the emergency medical dispatch centre and also are diagnosed as stroke at Södersjukhuset during the study period.

Exclusion Criteria:

* Cases where needed documents and files are missing.

Primary outcomes:
measure: Frequency of stroke symptoms
timeFrame: 1 h
Secondary outcomes:
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Karolinska Institutet, Intitution of clinical science and education, Södersjukhuset
Study officials:
affiliation: Karolinska Institutet, Intitution of clinical science and education, Södersjukhuset
name: Katarina Bohm, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05683236: The Clinical Effect of Palliative Treatment on Patients With Terminal Cancer
Official title: The Clinical Effect Evaluation of Multidisciplinary Collaborative Team Combined With Palliative Care Model in Patients With Terminal Cancer: A Randomised Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Multidisciplinary Collaborative
Palliative Care Model
Quality of Life
Lead sponsor: Shijiazhuang People's Hospital
Sponsor class: OTHER
First posted: 2023-01-13
Enrollment: 84
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study proposed a multidisciplinary collaborative team combined with a palliative care model and proposed to establish a team composed of medical staff in various disciplines to make up for the defects of a conventional nursing team. This study applied the multidisciplinary collaboration team combined with a palliative care model to patients with terminal cancer to evaluate its clinical effect.


Eligibility criteria: Inclusion Criteria:

* Patients were diagnosed as terminal by imaging, pathology and clinical manifestations
* the expected length of stay was more than seven days
* patients with clear consciousness, good communication and understanding ability
* voluntary participation in this study and signing of informed consent
* the estimated survival period is more than three months

Exclusion Criteria:

* Patients with cognitive impairment and mental illness
* those who were seriously ill and could not cooperate with the completion
* patients with severe communication disorders

Primary outcomes:
measure: Self-rating Anxiety Scale
timeFrame: Within 8 hours after hospitalization
measure: Self-rating Anxiety Scale
timeFrame: through study completion, an average of 1 year
measure: Self-rating Depression Scale
timeFrame: Within 8 hours after hospitalization
measure: Self-rating Depression Scale
timeFrame: through study completion, an average of 1 year
measure: Social Support Rating Scale
timeFrame: Within 8 hours after hospitalization
measure: Social Support Rating Scale
timeFrame: through study completion, an average of 1 year
measure: Quality of Life Scale
timeFrame: Within 8 hours after hospitalization
measure: Quality of Life Scale
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Shijiazhuang
country: China
facility: Shijiazhuang People's Hospital
Study officials:
References:
Clinical trial NCT05278936: New Technique in Congenital/Pediatric Cataract Surgery
Official title: A Simplified Sclerocorneal Incision/Tunnel in Performing Congenital/Pediatric Cataract Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pediatric Cataract
Congenital Cataract
Keywords: Corneoscleral incision
Cataract surgery
Vitreorrhexis
Anterior vitrectomy
Lead sponsor: Ibinsina Modern Eye and Retina Center
Sponsor class: OTHER
First posted: 2022-03-14
Enrollment: 52
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: In pediatric/congenital cataract surgery; multiple surgical interventions are performed, which needs multiple general anesthesias. Here, we describe a new technique, to end the operation in one session.

Detailed description: Generally, in congenital/pediatric cataract surgery, it might be possible to different multiple procedures with multiple general anesthesias. Here, the investigators found a new procedure to perform the cataract removal, intraocular implantation, and the anterior vitrectomy all in one session through a sclero-corneal tunnel. The corneoscleral tunnels are covered by the conjunctiva to abolish the need for both suturing and repeated general anesthesia to remove corneal sutures.

Eligibility criteria: Inclusion Criteria:

* Congenital/pediatric cataract

Exclusion Criteria:

* Aphakic and pseudophakic

Primary outcomes:
measure: Slit-lamp examination
timeFrame: The fourth weeks postoperatively
Secondary outcomes:
Other outcomes:
Locations:
city: Erbil
country: Iraq
facility: Ibinsina Modern eye and retina center
Study officials:
affiliation: Ibinsina Modern Eye and Retina Center
name: Omer Abdullah, M.Sc.
role: PRINCIPAL_INVESTIGATOR
affiliation: Dunya Goz Hospital
name: Huseyin Oksuz, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05055336: Longitudinal Evaluation of Gastric Emptying and Accommodation in Children With Dyspepsia
Official title: Longitudinal Evaluation of Gastric Emptying and Accommodation in Children With Dyspepsia: Toward Individualized Care in Functional Abdominal Pain Disorders
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Gastroparesis
Dyspepsia
Lead sponsor: University of Miami
Sponsor class: OTHER
Collaborators: name: American Neurogastroenterology and Motility Society
First posted: 2021-09-24
Enrollment: 0
Sex: ALL
Minimum age (years): 5
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this research is to further study the relationship between gastroparesis (GP) (a condition in which the stomach cannot empty itself of food in a normal fashion) and functional dyspepsia (FD) (frequent symptoms of indigestion that have no obvious cause).


Eligibility criteria: Inclusion Criteria:

* Able to complete the Pediatric Cardinal Symptoms Questionnaire
* Both parent and child must be able to speak and understand English or Spanish

Exclusion Criteria:

* Have global developmental delay, autism disorder, or psychosis
* Are nonverbal and/or illiterate
* Lack fluency in English or Spanish
* Have other GI comorbidities such as inflammatory bowel disease, celiac disease, eosinophilic esophagitis, peptic ulcer disease, GI malignancy, or gastroesophageal reflux disease responsive to medications (medical records will be reviewed to detect these exclusions)
* Have a history of surgical procedures that could have potentially affected their GI tract anatomy, such as fundoplication or Ladd's procedure.
* Healthy child presenting to their well child care visit must not report a history of dyspepsia, have a history of any gastrointestinal disease, or be taking any medication that can disturb the GI tract motility.

Primary outcomes:
measure: Gastric emptying rate
timeFrame: up to 6 months
Secondary outcomes:
measure: Percentage of food retained in the stomach
timeFrame: Day 1
measure: Pediatric Cardinal Symptoms Questionnaire Scores
timeFrame: Up to 6 months
Other outcomes:
Locations:
Study officials:
affiliation: University of Miami
name: Liz Febo-Rodriguez, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01493336: A Study of Capecitabine Rapid Disintegrating Tablets (RDT) Versus Commercial Xeloda in Patients With Solid Tumours
Official title: A Randomized, Open-label, Single Dose, Two-way Cross-Over Study to Investigate the Relative Bioavailability of Capecitabine in Rapid Disintegrating Tablets (RDT) Versus the Commercial Xeloda® Tablets Following Oral Administrations in Adult Patients With Solid Tumours
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Breast Cancer, Colorectal Cancer
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2011-12-15
Enrollment: 37
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This randomized, open-label, two-way crossover study will evaluate the relative bioavailabilty and safety of capecitabine rapid disintegrating tablets (RDT) versus commercial Xeloda tablets in patients with colorectal or breast cancer. Patients will be randomized to a sequence of single oral doses of capecitabine RDT or Xeloda on Days 1 and 2 of a 14-day treatment cycle with Xeloda. Follow-up will be 30 days.


Eligibility criteria: Inclusion Criteria:

* Adult patients,\>/= 18 years of age
* Histological/cytological confirmation of colorectal or breast cancer
* Patient is ambulatory and has a Karnofsky performance status of \> 70%
* Body surface area between 1.5 and 2.0 m2
* Either:
* Due to receive Xeloda as monotherapy or as combination therapy as per their treating physician's treatment plan, or
* Currently receiving Xeloda monotherapy and in the investigator's opinion able to tolerate study drug dose on Day 1 and Day 2

Exclusion Criteria:

* Any contraindication to Xeloda
* Received Xeloda in the 6 days prior to Day 1
* Subjects with organ allografts (other than autologous bone marrow transplant after high dose chemotherapy)
* Renal impairment
* Pregnant or lactating females
* Participation in an investigational drug study within 28 days prior to screening
* Lack of physical integrity of the upper gastrointestinal tract, or clinically significant malabsorption syndrome
* Serious uncontrolled intercurrent infections
* History of clinically significant coronary artery disease
* Concomitant treatment with warfarin
* Known dihydropyrimidine dehydrogenase deficiency

Primary outcomes:
measure: Relative bioavailability: Area under the concentration-time curve (AUC)
timeFrame: Multiple sampling pre-dose to 6 hours post-dose
Secondary outcomes:
measure: Safety: Incidence of adverse events
timeFrame: 30 days
Other outcomes:
Locations:
city: Adelaide
country: Australia
state: South Australia
city: Nedlands
country: Australia
state: Western Australia
city: Christchurch
country: New Zealand
city: Grafton
country: New Zealand
city: Glasgow
country: United Kingdom
city: Leeds
country: United Kingdom
city: London
country: United Kingdom
city: Newcastle upon Tyne
country: United Kingdom
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References:
Clinical trial NCT01484236: National Lymphangioleiomyomatosis Registry, France
Official title: National Lymphangioleiomyomatosis Registry, France
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Lymphangioleiomyomatosis
Keywords: Lymphangioleiomyomatosis
Lead sponsor: Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires
Sponsor class: OTHER
Collaborators: name: Hospices Civils de Lyon
First posted: 2011-12-02
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with lymphangioleiomyomatosis

Brief summary: RE-LAM-CE is a registry of lymphangioleiomyomatosis cases in France. its aim is to determine the incidence and prevalence of lymphangioleiomyomatosis in France, including demographic information and information concerning the timing and modalities of diagnosis.

Based on the registry, we will set up a prospective cohort of patients. The database will include detailed medical information, particularly regarding progression of the respiratory function.

Detailed description: Lymphangioleiomyomatosis is a rare pulmonary disease occuring preferentially in women. Few data are available regarding the epidemiology of this disease, the frequency of the various forms with mild to moderate or severe disease, and the rapid or slow progression.

Several sources of information will be used in order to increase completeness. The registry will also allow to estimate the proportion of patients with lymphangioleiomyomatosis who are managed by the Reference Center and Competence Centers for rare lung diseases in France.

Data will be collected by a research assistant, and the study will be coordinated by the Pole IMER - Department of Public health and Epidemiology of HCL (Lyon Hospitals).

This study will provide a better knowledge on the natural course of the disease and the variability in severity and progression of lymphangioleiomyomatosis, and the applicability of diagnostic criteria proposed in 2009. This study will provide the first detailed epidemiological information on Lymphangioleiomyomatosis, will assess the management of this rare disease within the French National Plan for rare diseases 2005 - 2009, and will provide valuable medical information prior to the establishment of clinical trials

Eligibility criteria: Inclusion Criteria:

* Patients with sporadic lymphangioleiomyomatosis or associated with Tuberous sclerosis.
* patients diagnosed or hospitalized or seen in consultation since 01/01/2008

Exclusion Criteria:

* None

Primary outcomes:
measure: Number of cases
timeFrame: 4 years
Secondary outcomes:
measure: localisation of cases
timeFrame: 4 years
measure: Progression-free survival
timeFrame: 4 years
measure: Progression-free survival
timeFrame: 4 years
Other outcomes:
Locations:
city: Lyon
country: France
facility: Hôpital Louis Pradel
Study officials:
affiliation: Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires, HCL
name: Vincent Cottin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01887236: The Effect of Exercise Training Programs: Step and Stability Ball on Balance and Obstacle Avoidance in Older People
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Aging
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2013-06-26
Enrollment: 45
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Individuals of advanced age undergo both physical and cognitive deterioration. The aim of this study is to explore the effect of two types of physical activity on stability parameters.


Eligibility criteria: Inclusion Criteria:

* Age above 65
* Able to undergo physical activity for 45 minutes twice a week

Exclusion Criteria:

* All Others

Primary outcomes:
measure: Stability
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Netanya
country: Israel
facility: Zinman College for Physical Education and Sport Sciences
Study officials:
References:
Clinical trial NCT02316236: Dexmedetomidine to Improve Outcomes During Emergence From Retroperitoneal Laparoscopic Surgery
Official title: Effect of Dexmedetomidine on Outcomes During Emergence From Retroperitoneal Laparoscopic Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anesthesia
Lead sponsor: Air Force Military Medical University, China
Sponsor class: OTHER
First posted: 2014-12-12
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study is to observe whether dexmedetomidine could reduce agitation during emergence from general anesthesia in patients undergoing retroperitoneal laparoscopic surgery.

Detailed description: Agitation during emergence is frequent after retroperitoneal urologic surgery. Dexmedetomidine is alpha-2 receptor agonist which shows sedative and algesic effect. In this study we will compare the effect of dexmedetomidine given by different protocols on emergence agitation.

Eligibility criteria: Inclusion Criteria:

* Patients scheduled for retroperitoneal laparoscopic surgery
* Patients with written informed consent

Exclusion Criteria:

* Patients with difficulty of communication
* Patients with risk of obstructive sleeping apnea syndrome

Primary outcomes:
measure: Richmond Score
timeFrame: From end of sevoflurane inhalation to departure from PACU, an expected average of 1 hour
Secondary outcomes:
measure: Cough score
timeFrame: From end of sevoflurane inhalation to departure from PACU, an expected average of 1 hour
measure: Time to awake
timeFrame: From end of sevoflurane inhalation to departure from PACU, an expected average of 1 hour
Other outcomes:
Locations:
city: Xi'an
country: China
facility: Xijing Hospital
state: Shaanxi
Study officials:
affiliation: Air Force Military Medical University, China
name: Lize Xiong, PhD
role: STUDY_CHAIR
References:
citation: Yang S, Lee H. A dose-finding study of preoperative intravenous dexmedetomidine in children's emergence delirium after epiblepharon surgery. Eur J Ophthalmol. 2014 May-Jun;24(3):417-23. doi: 10.5301/ejo.5000396. Epub 2013 Nov 29.
citation: Kim SY, Kim JM, Lee JH, Song BM, Koo BN. Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery. Br J Anaesth. 2013 Aug;111(2):222-8. doi: 10.1093/bja/aet056. Epub 2013 Mar 22.
citation: Ibacache ME, Munoz HR, Brandes V, Morales AL. Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children. Anesth Analg. 2004 Jan;98(1):60-63. doi: 10.1213/01.ANE.0000094947.20838.8E.