Clinical trial NCT01840839: Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
Official title: Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Slow Wave Sleep in Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Older Adults (50-90 Years)
Keywords: aging
cognitive decline
brain stimulation
tSOS
tDCS
sleep
nap
daytime sleep
memory
memory consolidation
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2013-04-26
Enrollment: 18
Sex: ALL
Minimum age (years): 50
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The beneficial effect of nocturnal as well as daytime sleep on memory consolidation is well-documented in young, healthy subjects. Slow wave sleep (SWS), in particular, with its slow oscillating activity have shown to enhance declarative, hippocampus-dependent memory representations. This impact of sleep on memory performance can be additionally enhanced by exogeneous induction of transcranial slow oscillating stimulation (tSOS) within the frequency range of SWS in humans (0,7- 0,8 Hz) during sleep, as has been demonstrated in young, healthy subjects. If older adults that commonly experiencing cognitive decline, including long-term retention of declarative memory - benefit from transcranial slow oscillatory stimulation (tSOS) during sleep in the same way has not been studied so far. The primary goal of the study is therefore to investigate the impact of oscillating current stimulation (tSOS) during a daytime nap on declarative memory consolidation in older adults.


Eligibility criteria: Inclusion Criteria:

* age: 50-90 years
* right handed
* inobtrusive neuropsychological examination

Exclusion Criteria:

* untreated severe internal or psychiatric diseases
* epilepsy
* other severe neurological diseases eg., previous major stroke, brain tumour
* dementia
* contraindications to MRI

Primary outcomes:
measure: Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS
timeFrame: 4 weeks
Secondary outcomes:
measure: 1. Amount of Slow wave Sleep
timeFrame: 4 weeks
measure: 2. sleep spindels
timeFrame: 4 weeks
measure: 3. EEG-correlates
timeFrame: 4 weeks
measure: 4. further memory systems
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Charite CCM Neurologie Berlin
Study officials:
affiliation: Charite Universitätsmedizin Berlin - Neurologie
name: Agnes Flöel, Professor
role: STUDY_CHAIR
affiliation: Charite Universitätsmedizin Berlin - Neurologie
name: Agnes Flöel, Professor
role: PRINCIPAL_INVESTIGATOR
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citation: Ladenbauer J, Kulzow N, Passmann S, Antonenko D, Grittner U, Tamm S, Floel A. Brain stimulation during an afternoon nap boosts slow oscillatory activity and memory consolidation in older adults. Neuroimage. 2016 Nov 15;142:311-323. doi: 10.1016/j.neuroimage.2016.06.057. Epub 2016 Jul 2.
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