Clinical trial NCT01854268: Respiratory Kinematics During Voluntary and Reflex Cough in Healthy Adults
Official title: Respiratory Kinematics During Voluntary and Reflex Cough in Healthy Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Cough
Keywords: cough
Lead sponsor: University of Florida
Sponsor class: OTHER
First posted: 2013-05-15
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Cough is a defensive behavior that involves three stages. A large inspiratory phase, a compression phase where the vocal folds close and subglottal pressure is developed, and an expiratory phase. Cough serves to protect the upper and lower airways from material such as liquids, solids, or saliva, that have been aspirated. There are two types of cough: voluntary and reflex cough. Voluntary cough involves a cough to command. Reflex cough is a cough that is generated secondary to a stimulus in or near the airway. There has been some research regarding the differences between voluntary and reflex cough. However, no research has described the differences in airflow or movement pattern (kinematics) between the two types of cough. This study seeks to determine the respiratory kinematics and airflow differences between voluntary and reflex cough in healthy participants.

Detailed description: As a participant, completion of this study will require the following:

Investigators will first place cotton elastic bands around your chest and abdomen so that measures of chest wall and abdominal movements can be measured. Then, tests of your breathing made from pulmonary function testing will be completed.

Investigators will then have you complete a maximum inspiration followed by a maximum expiration three times.

Investigators will ask you to produce a voluntary cough three times into a facemask which is attached to a computer.

Then the investigators will provide you with nebulized water (FOG) through the facemask for up to a minute three times. You will have a minute break in between each presentation.

Finally, the investigators will provide you with a nebulized dose of Capsaicin, which is derived from hot peppers, through the same facemask used in all of the above tasks. You will receive three doses of capsaicin and be provided with water at any time during the study.

Eligibility criteria: Inclusion Criteria:

* Healthy adults between the ages of 18-80 years.
* Ability to provide informed consent.

Exclusion Criteria:

* No history of smoking within the last 5 years as this reduces the sensitivity to capsaicin
* No history of neurological disease (i.e. Parkinson's disease, stroke, traumatic brain injury, etc.)
* No known allergy to capsaicin
* No history of respiratory disease (i.e. asthma, chronic obstructive pulmonary disease, or respiratory infection within the last 5 weeks.)

Primary outcomes:
measure: Lung Volume Initiation
timeFrame: 1 hour
Secondary outcomes:
measure: Peak Expiratory Airflow Rate
timeFrame: 1 hour
measure: Urge-to-cough
timeFrame: 1 hour
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: University of Florida, Dauer Hall
state: Florida
Study officials:
affiliation: University of Florida
name: Alexandra E. Brandimore, M.A.
role: PRINCIPAL_INVESTIGATOR
References: