Clinical trial NCT01733563: Sugar Sweetened Beverages (SSB)- Effects on Metabolism
Official title: Effects of Carbohydrate Containing Diets on Lipid Metabolism & Fatty Acid Oxidation in Healthy Young Men - a Randomized, Double-Blinded Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Metabolism
Keywords: sugar sweetened beverages
fructose
lipogenesis
beta-oxidation
Lead sponsor: University of Zurich
Sponsor class: OTHER
Collaborators: name: SNF Swiss National Foundation
name: University of Lausanne
First posted: 2012-11-27
Enrollment: 96
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The objective of this study is to investigate the impact of sugar sweetened beverages on the fat metabolism of healthy young men. It is well known that consumption of beverages sweetened with fructose is associated with different health risks such as type 2 diabetes. The present study has been designed to dissect differences in the metabolic pathways of fructose and glucose, but also metabolic adaptations during fructose, glucose and sucrose diets. During a period of seven weeks subjects will consume either fructose, glucose or sucrose sweetened beverages or continue their usual drinking habits. During these seven weeks there will be different metabolic investigations using stable isotope tracers. First, the rate of lipolysis and beta-oxidation will be determined. Second, the rates of fatty acid synthesis will be measured. During all examinations there will also be substrate- and energy-utilization measurements by indirect calorimetry, blood analysis and morphometric measurements. Based on the literature main hypotheses are: Fructose enhances de novo lipogenesis postprandially and also in the fasting state significantly more than glucose by enhanced expression of lipogenic enzymes. Fructose decreases beta oxidation via downregulation of oxidative enzymes.


Eligibility criteria: Inclusion criteria:

* Healthy male volunteers aged 18-30
* BMI between 19-24 kg/m2
* Non-smoker

Exclusion criteria:

* Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study.
* Diabetes
* Known alcohol, substance or drug abuse, concomitant medication
* More than three hours of physical exercise per week
* Consumption of more than 2 times 3 dl SSB daily
* Subjects likely to fail to comply with the study protocol
* Subjects who do not give informed consent

Primary outcomes:
measure: Lipogenesis
timeFrame: After total 6 weeks dietary intervention
Secondary outcomes:
measure: Lipolysis
timeFrame: After total 6 weeks dietary intervention
Other outcomes:
measure: Waist/Hip Ratio
timeFrame: After total 6 weeks dietary intervention
Locations:
city: Zurich
country: Switzerland
facility: University Hospital Zurich, Endocrinology and Diabetology
state: ZH
Study officials:
affiliation: University Hospital Zurich, Endocrinology and Diabetology
name: Philipp Gerber, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Geidl-Flueck B, Hochuli M, Nemeth A, Eberl A, Derron N, Kofeler HC, Tappy L, Berneis K, Spinas GA, Gerber PA. Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial. J Hepatol. 2021 Jul;75(1):46-54. doi: 10.1016/j.jhep.2021.02.027. Epub 2021 Mar 6.