Clinical trial NCT04885322: Effects of PFC tDCS on Cognitive Control, Attention Lapses and Coordinated Neural Activity in the Theta and Alpha Bands
Official title: Effects of PFC tDCS on Cognitive Control, Attention Lapses and Coordinated Neural Activity in the Theta and Alpha Bands
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Healthy
Lead sponsor: University of California, Davis
Sponsor class: OTHER
First posted: 2021-05-13
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated by transcranial direct current stimulation (tDCS) at frontal and occipital scalp sites. Testing the effects of tDCS at these scalp sites on cognitive task performance will help us understand the roles of the brain regions corresponding to these sites during higher-order cognitive processing (language comprehension, cognitive control, and related attention and memory processes). Behavioral and electrophysiological (EEG) measures will be used to assess cognitive performance. Our overarching hypothesis is that stimulating prefrontal circuits with tDCS can improve cognitive control performance, and ultimately performance on a range of cognitive tasks, as compared to stimulating a different cortical region (occipital cortex) or using sham stimulation.

This study is solely intended as basic research in order to understand brain function in healthy individuals and individuals with schizophrenia. This study is not intended to diagnose, cure or treat schizophrenia or any other disease.


Eligibility criteria: Inclusion Criteria:

* between ages of 18 and 50
* ability to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks
* ability to give valid informed consent

Exclusion Criteria:

* no history of head trauma
* no current or previous history of treatment with psychotropic medication
* corrected vision 20/30 or better
* tDCS/MRI contraindications, including: pregnancy, ferrous metal in any part of the body, serious medical conditions, claustrophobia, metallic implants, skin damage, conditions such as eczema at electrode sites, cranial pathologies

Primary outcomes:
measure: Behavioral Cognitive Control Measures on the Stroop Task
timeFrame: Through study completion, an average of 1 month
measure: EEG Cognitive Control Measures on the Stroop Task
timeFrame: Through study completion, an average of 1 month
measure: Behavioral Attention Lapse Measures on the Stroop Task
timeFrame: Through study completion, an average of 1 month
measure: EEG Attention Lapse Measures on the Stroop Task EEG Attention Lapse Measures on the Stroop Task
timeFrame: Through study completion, an average of 1 month
measure: Behavioral Cognitive Control Measures on the Change Detection Task Behavioral Cognitive Control Measures on the Change Detection Task
timeFrame: Through study completion, an average of 1 month
measure: EEG Cognitive Control Measures on the Change Detection Task
timeFrame: Through study completion, an average of 1 month
measure: Behavioral Attention Lapse Measures on the Change Detection Task
timeFrame: Through study completion, an average of 1 month
measure: EEG Attention Lapse Measures on the Change Detection Task
timeFrame: Through study completion, an average of 1 month
measure: Delivered tDCS Dose to PFC
timeFrame: Through study completion, an average of 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Sacramento
country: United States
facility: Imaging Research Center
state: California
Study officials:
References: