louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02886663: Visual Field Restoration in Patients With Post-stroke Homonymous Hemianopsia
Official title: Visual Field Restoration in Patients With Post-stroke Homonymous Hemianopsia
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Hemianopsia
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
First posted: 2016-09-01
Enrollment: 9
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: This study will assess the effectiveness of a stimulus, in the blind field of hemianopsic patients, to restore the vision of patients with homonymous hemianopsia consecutive to stroke (unilateral occipital lesion). Hemianopsia occurs in 30% of strokes regardless of the cerebral localization and in 60% of stroke interesting the territory of the posterior cerebral artery.


Eligibility criteria: Inclusion Criteria:

* Presence of an homonymous visual field amputation after vascular retrochiasmatic lesion of the occipital region (visual cortex alone or with optical radiations or with other associated occipital areas)
* inclusion 3 months to 36 months after stroke
* Patients aged 18 years and older

Exclusion criteria:

* Brain injury history
* Severe neuropsychological, psychiatric or behavioral disorder
* Severe eye disorder or visual impairment (visual acuity less than 3/10)
* Progressive eye disorder (cataracts or glaucoma)
* insufficient French language proficiency to understand the questionnaires and rehabilitation tasks
* patient under legal protection
* patient's opposition to participate in the study
* no medical insurance coverage
* pregnant pr breastfeeding patient

Primary outcomes:
measure: change in the sensitivity of detection of a visual stimulus after rehabilitation
timeFrame: change from baseline sensitivity at week 22
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Fondation Ophtalmologique Adolphe de Rothschild
Study officials:
affiliation: Fondation OPH A de Rothschild
name: Sylvie CHOKRON
role: STUDY_DIRECTOR
affiliation: Fondation OPH A de Rothschild
name: Olivier GOUT, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02734563: Collagen Alterations in Patients With Abdominal Wall Hernias
Official title: Collagen Alterations in Patients With Abdominal Wall Hernias
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hernia, Abdominal
Lead sponsor: Bispebjerg Hospital
Sponsor class: OTHER
First posted: 2016-04-12
Enrollment: 174
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Males with multiple hernias wer identified from the Danish Hernia Database. The control group were recruited from hospital staff.

Brief summary: The aim of this study was to evaluate collagen turnover in patients with multiple hernias

Detailed description: Venous blood was collected and markers for type IV and V collagen synthesis and breakdown was measured

Eligibility criteria: Inclusion Criteria:

* patients with a history of three hernia repairs (multiple hernia group)
* patients without any history or presence of hernias (control group)

Exclusion Criteria:

* connective tissue disorder (Ehlers-Danloss/Marfan)
* presence of hernia upon clinical examination (control group)

Primary outcomes:
measure: Type IV and V collagen synthesis and breakdown
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Bispebjerg Hospital
state: NV
Study officials:
affiliation: Bispebjerg Hospital, Dept. of Surgery
name: Lars N Jorgensen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05789563: Comparison of SpO2 Measurement Accuracy of Different Types of Smartwatches
Official title: Comparison of SpO2 Measurement Accuracy of Different Types of Smartwatches
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hypoxia
Keywords: SpO2
Pulse oximetry
Smartwatch
Lead sponsor: Czech Technical University in Prague
Sponsor class: OTHER
First posted: 2023-03-29
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: All participants go through all study arms, in random order. Two measuring devices are active simultaneously during each measurement on each participant and their functioning is compared.
Primary purpose: OTHER

Brief summary: The aim of the study is to compare the accuracy of peripheral blood oxygen saturation measurements using smartwatches from three manufacturers compared to a standard medical pulse oximeter.

Detailed description: The aim is to create a study that compares multiple smartwatch models simultaneously with a standard medical pulse oximeter using a single measurement methodology. According to the available literature, no such study exists. The methodology of the study and the subsequent statistical evaluation are based on the guidelines of the standard ČSN EN ISO 80601-2-61, which specifies requirements for the basic safety and necessary functionality of pulse oximetry devices. The comparison will be performed non-invasively in healthy volunteers during gradual desaturation in the range of 70-100 % SpO2 (normobaric hypoxia). The data obtained could help to increase the awareness of the possibilities of SpO2 monitoring using smartwatches in medical conditions that are manifested by a decrease in SpO2 level over a longer time period, where measurement with a conventional oximeter is impractical.

Eligibility criteria: Inclusion Criteria:

* Passing the initial examination, which will determine the following data: wrist circumference, heart rate, blood pressure and blood oxygen saturation

Exclusion Criteria:

* pregnancy
* severe cardiovascular conditions
* severe asthma or other severe respiratory conditions
* injury to the upper limbs or hands that could affect the peripheral perfusion
* diabetes
* hypotension or hypertension

Primary outcomes:
measure: Similarity of SpO2 readings
timeFrame: Under 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Kladno
country: Czechia
facility: Czech Technical University in Prague
Study officials:
affiliation: Czech Technical University in Prague
name: Jakub Rafl, PhD.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Rafl J, Bachman TE, Rafl-Huttova V, Walzel S, Rozanek M. Commercial smartwatch with pulse oximeter detects short-time hypoxemia as well as standard medical-grade device: Validation study. Digit Health. 2022 Oct 11;8:20552076221132127. doi: 10.1177/20552076221132127. eCollection 2022 Jan-Dec.
Clinical trial NCT01378663: Review of Pain Management After Congenital Cardiac Surgery
Official title: Review of Pain Management After Congenital Cardiac Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Pain Management
Keywords: Congenital cardiac surgery
Postoperative pain management
Lead sponsor: Nationwide Children's Hospital
Sponsor class: OTHER
First posted: 2011-06-22
Enrollment: 92
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients that underwent congenital cardiac surgery from 2004 till 2010 and required PCA or NCA.

Brief summary: One of the main problems that faces children undergoing congenital cardiac surgery is posoperative pain management. PCAs (Patient Controlled Analgesia) and NCAs (Nurse Controlled Analgesia) are the main means of pain management here at NCH. In this study, the investigators will review the difference between different PCA and NCA modalities. Also, the investigators aim to find out if there are differences between age groups in terms of type of drug used, total drug used, side effects and length of use of the PCA or NCA.

Detailed description: All patients that underwent congenital cardiac surgery from 2004 till 2010 and required PCA or NCA will be included. Data will be collected from the pain team database and charts review. Data will include; patient's age, weight, sex, procedure, pain scores and sedation score during the times of PCA and NCA use, side effects (respiratory depression, nausea, vomitting, pruritus, itching and other).In addition we will record the total days of PCA and NCA use. We will also look at the incidence of changes done in the PCA/NCA and drug itself.

Identifying the ideal drug and dose based on the patient's age and procedure will allow us to take better care of our patients. Our patient population is peculiar in the fact that a big percentage of our patients are extubated in the Operating Room. For this reason, sedation and analgesia play an important role for our continued success in taking care of them.

Eligibility criteria: Inclusion Criteria:

* All patients that underwent congenital cardiac surgery from 2004 till 2010 and required PCA or NCA.

Exclusion Criteria:

* All patients that underwent congenital cardiac surgery from 2004 till 2010 and did not receive PCA or NCA for postoperative pain management.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Columbus
country: United States
facility: Nationwide Children's Hospital
state: Ohio
Study officials:
affiliation: Nationwide Children's Hospital
name: Aymen N Naguib, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Howard RF, Lloyd-Thomas A, Thomas M, Williams DG, Saul R, Bruce E, Peters J. Nurse-controlled analgesia (NCA) following major surgery in 10,000 patients in a children's hospital. Paediatr Anaesth. 2010 Feb;20(2):126-34. doi: 10.1111/j.1460-9592.2009.03242.x.
Clinical trial NCT05754463: The Effect Of Plyometric Training On Balance And Proprioception In Different Branches Athletes
Official title: The Effect Of Plyometric Training On Balance And Proprioception
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Athlete Foot
Keywords: Plyometrics
Balance
Proprioception
Lead sponsor: Baskent University
Sponsor class: OTHER
Collaborators: name: Okan University
First posted: 2023-03-03
Enrollment: 54
Sex: ALL
Minimum age (years): 12
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this study is to investigate the effect of plyometric training on balance and proprioception in athletes in different branches.

54 athletes participated in the study. Two groups were included as 27 athletics and 27 karate groups. Plyometric training was applied to the athletes participating in our study, 2 days a week for 6 weeks, after 20 minutes of warming up and stretching movements before each training. Sociodemographic characteristics of the athletes were recorded. Dynamic balance Y balance test and static balance Stroke balance test; sense of proprioception was evaluated with Angle reproduction test.


Eligibility criteria: Inclusion Criteria:

* Being a licensed athlete in the province of Tokat
* Being an athlete who trains regularly
* To be healthy, between the ages of 12 and 18
* Volunteering to work.

Exclusion Criteria:

* Presence of any disturbance that may affect balance and balance reactions,
* Musculoskeletal injury in the last 6 months,
* Presence of previous musculoskeletal surgery,
* Pregnancy,
* Having an acute or chronic illness or injury that will limit performance in training or a match,
* Calcification or other bone and joint problems,
* Using cigarettes, alcohol, and drugs that affect balance.

Primary outcomes:
measure: Plyometric training
timeFrame: 2 days a week for 6 weeks
measure: Y balance Test
timeFrame: 6 weeks
measure: Stroke Balance Test
timeFrame: 6 weeks
measure: Proprioception assessment (Eyes-closed kinematic angle reproduction test)
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: The Effect of Plyometric Training on Balance and Proprioception in Different Branches Athletes
Study officials:
affiliation: Baskent University
name: Mustafa Gulsen
role: STUDY_DIRECTOR
References:
Clinical trial NCT06006663: Effect of Hebal and Synthetic Medicamentss on Enterococcus Feacalis
Official title: Antimicrobial Efficacy of Synthetic Versus Herbal Intracanal Medicaments Against Enterococcus Faecalis
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE2
PHASE3
Conditions: Effective Intracanal Medicaments Against Enterococcus Faecalis
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2023-08-23
Enrollment: 32
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: this study aims to evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases.

Detailed description: we evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases by taking three samples from root canal , the first sample after removing gutta percha from root canal system, the second sample after shaping with protaper universal files and cleaning with 2.5% sodium hypochlorite , the third sample after 7 days from application of the medication .

samples will be diluted into ten fold serial dilution and then the diluted samples will be cultured on bile esculin agar as it is selective media for enterococcus feacalis.

bacterial reduction will be determined and comparision will be made .

Eligibility criteria: Inclusion Criteria:

* Single rooted teeth.
* Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.
* Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.

Exclusion Criteria:

* • Teeth with fractures of the crown or root.

  * Teeth with periodontal pocket deeper than 4mm.
  * Teeth have procedural error like ledge, broken instrument, or perforation.

Primary outcomes:
measure: measurment of microbial reduction as result of applying synthetic and herbaal intracanal medicaments
timeFrame: time necessary for incubation of each sample is 24 hour
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06785363: The Study Focuses on the Release of the Iliolumbar Ligament Using a Pumped Technique, Addressing Its Tightness Caused by Excessive Anterior Pelvic Tilt During Pregnancy. This Condition Often Results in Low Back Pain and Mechanical Dysfunction of the Lumbar and Sacroiliac Regions.
Official title: Effect of Pumped Technique for Ilio-lumber Ligament Release on Postnatal Low Back Pain
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Low Back Pain
Keywords: low back pain
lumbar and sacroiliac pain
iliolumbar ligament disorder
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-01-21
Enrollment: 40
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The iliolumbar ligament, one of the sacroiliac ligaments, has been identified in recent research as a contributor to low back pain when tight. During pregnancy, hormonal changes and postural changes can cause this ligament to tighten, leading to pain. Releasing the iliolumbar ligament can reduce low back pain and restore normal mechanical function.

Detailed description: Group A (Control group) It will be consisted of postnatal women and will be treated by hot packs for 20 minutes three times per week for 8 weeks.

Group B (study group) the participant will treated by hot packs for 20 min in additional to pumping technique for iliolumbar ligament release for 30 min. 3 times per week for 8 weeks.

Eligibility criteria: Inclusion Criteria:

1- the women are delivery within 3 months. 3- Their BMI must be less than 30 Kg\\m 2 . 4- Its included primipara or multipara. 5- Its included be normal vaginal labor delivery or caesarian section.

Exclusion Criteria:

1. Clinical diagnosis by Lumbar disc prolapse.
2. Clinical diagnosis by Lumbar spondylolysis and spondlysis.
3. Clinical diagnosis by back trauma or fracture.
4. Clinical diagnosis by Lumbar canal stenosis.
5. Clinical diagnosis by Rheumatoid arthritis.
6. Clinical diagnosis by Malignancy.
7. Clinical diagnosis by any deformity for low limb.
8. Clinical diagnosis by Scoliosis.
9. Taking analgesic drugs.
10. Clinical diagnosis by Deep vein thrombosis

Primary outcomes:
measure: Visual analog scale (VAS):
timeFrame: 8 weeks
measure: Goniometer
timeFrame: 8 weeks
measure: Inclinometer
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo university
Study officials:
References:
Clinical trial NCT03381963: Hemostatic Profiles of Endocrine Therapies for Breast Cancer
Official title: Hemostatic Profiles Associated With Use of Aromatase Inhibitors and Tamoxifen in Women With Breast Cancer : a Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Breast Neoplasms
Venous Thromboembolism
Keywords: tamoxifen
aromatase inhibitors
breast cancer
venous thromboembolism
Lead sponsor: University Hospital, Geneva
Sponsor class: OTHER
First posted: 2017-12-22
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women with a new diagnosis of non-metastatic breast cancer and a planned adjuvant endocrine therapy.

Brief summary: The aim of this prospective cohort study is to evaluate the modifications of the biological hemostatic profile associated with the use of endocrine therapy in women with breast cancer (tamoxifen or aromatase inhibitors).

Detailed description: In this cohort study, women with breast cancer and an indication for endocrine therapy will be prospectively enrolled. At the 1st visit (before the start of endocrine therapy (tamoxifen or aromatase inhibitor)) and at the 2nd visit (at \~3 months after the start of treatment), demographical / clinical data and blood samples will be collected. We will evaluate the hemostatic biological profiles associated with the use of endocrine therapy by comparing hemostatic biomarkers before and during its use.

Eligibility criteria: Inclusion Criteria: adult women with a diagnosis of non-metastatic breast cancer and an indication for adjuvant endocrine therapy

Exclusion Criteria:

* lack of consent
* planned chemotherapy
* personal history of venous thromboembolism
* ongoing anticoagulant treatment

Primary outcomes:
measure: Change in thrombin generation, including APC sensitivity ratio
timeFrame: three months
Secondary outcomes:
measure: Change in levels of coagulation factors
timeFrame: three months
measure: Change in fibrinolytic time
timeFrame: three months
Other outcomes:
Locations:
city: Geneva
country: Switzerland
facility: Geneva University Hospitals
Study officials:
References:
citation: Blondon M, Bodmer A, Thouvenin L, Lecompte T, Righini M, Fontana P, Casini A. Differential impact of tamoxifen and aromatase inhibitors on thrombin generation: the prospective HEMOBREAST cohort. Blood Adv. 2022 May 10;6(9):2884-2892. doi: 10.1182/bloodadvances.2021006623.
Clinical trial NCT02481063: Adaptation in Lower Extremity After 3 Running Days, With a Group Trained by Eccentric Overload
Official title: Differences in Muscle (Vastus Laterals and Gastrocnemius Medialis) and Tendon Adaptation (Patellar and Achilles) in Lower Extremity After 3 Running Days With a Group Trained by Eccentric Overload, Measured by Ultrasound and Thermography
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sports Injuries
Keywords: Eccentric
Running
Muscle
Tendon
Ultrasound
Thermography
Lead sponsor: Universidad San Jorge
Sponsor class: OTHER
Collaborators: name: University of Jaén
First posted: 2015-06-25
Enrollment: 19
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: This study evaluates the changes in muscles and tendons in the lower limb after an intervention of fatigue during 3 consecutive days between trained or not healthy subjects. One of the 2 groups received training by eccentric overload previously.

Detailed description: Changes in muscle and tendon tissues, due to exercise, could determine in the future the possibility of an injury. Understand the changes in the mechanical tissues is a key tool for prevention.

The evaluation of the thickness and area in tendons, the existence of new vessels within the tendon, muscle pennation angle or thermography are tools that have been widely used to detect these changes.

Running is one of the activities that can cause more muscle-tendon injuries, specially overuse injuries. However, the eccentric exercise suggest to make some adaptations in different tissues that may be beneficial to prevent damage after exercise.

Eligibility criteria: Inclusion Criteria:

* Healthy subjects that performs any sport usually
* Subjects that never have made eccentric training will be included.
* Subjects must be willing to perform the procedure
* Sign informed consent

Exclusion Criteria:

* Subjects enrolled with lower limb pathology in last 6 months
* Subjects that don´t complete all the procedure will be excluded.

Primary outcomes:
measure: Composite Measure with Ultrasound in Tendons and Muscles
timeFrame: Change from Baseline in tendon structure, an expected average of 3 days of running
Secondary outcomes:
measure: Temperature changes in Patellar and Achilles Tendon as assessed by thermography
timeFrame: Change from Baseline in tendon structure after 3 days of running. Just immediately and 10 minutes after intervention
Other outcomes:
Locations:
city: Villanueva de Gallego
country: Spain
facility: Universidad San Jorge
state: Zaragoza
Study officials:
affiliation: Universidad San Jorge
name: César Berzosa, Ph.D
role: STUDY_DIRECTOR
References: