louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00454025: Intraocular Pressure (IOP) Changes Associated With Muslim Prayer Postural Changes
Official title: Intraocular Pressure Changes Associated With Muslim Prayer Postural Changes
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Glaucoma
Keywords: glaucoma
intraocular pressure
postural changes
Lead sponsor: University of Colorado, Denver
Sponsor class: OTHER
First posted: 2007-03-29
Enrollment: 5
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients 18 and up, diagnosed with primary open angle glaucoma, and are able to assume the standing, bowing, and prostrate positions.

Brief summary: Elevated intraocular pressure is widely accepted as a risk factor for glaucoma and controlling the pressure remains the cornerstone of effective treatment. There is evidence that posture can have a significant effect on intraocular pressure fluctuations. Salat (or Salah) refers to the five daily prayers performed by Muslims. The time spent praying in a kneeling or prostrate position may be associated with wide fluctuations in intraocular pressure, potentially sight-threatening for Muslim patients with glaucoma. The researchers seek to investigate the link between traditional daily Muslim prayer postural changes and intraocular pressure changes.


Eligibility criteria: Inclusion Criteria:

* Diagnosed with primary open angle glaucoma
* Must be age 18 and up
* Provide written informed consent to participate
* Able to cooperate with ocular examination for 60-90 minutes
* Able to assume the standing, bowing, and prostrate positions

Exclusion Criteria:

* Special patient populations (children, pregnant women, prisoners etc.)
* Patients who have had glaucoma surgery that could effect the change in intraocular pressure (ie trabeculectomy, tube-shunts, etc.)
* Patients who are unable to assume bowing or kneeling positions

Primary outcomes:
measure: Intraocular Pressure
timeFrame: Single Exam
Secondary outcomes:
measure: Positional Intraocular Pressure Changes
timeFrame: Single Exam
Other outcomes:
Locations:
city: Aurora
country: United States
facility: Rocky Mountain Lions Eye Institute
state: Colorado
Study officials:
affiliation: Rocky Mountain Lions Eye Institute
name: Malik Y. Kahook, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02320825: Randomized Study Comparing Local Tumor Control After Post-Operative Single-Fraction or Hypofractionated Stereotactic Radiosurgery in the Treatment of Spinal Metastases
Official title: Phase III Multicenter Randomized Study Comparing Local Tumor Control After Post-Operative Single-Fraction or Hypofractionated Stereotactic Radiosurgery in the Treatment of Spinal Metastases
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Spinal Metastases
Keywords: Stereotactic Radiosurgery (SRS)
Single-Fraction
Hypofractionated
Spinal surgery
14-233
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
Collaborators: name: Johns Hopkins University
name: Massachusetts General Hospital
name: Stanford University
First posted: 2014-12-19
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to find out whether giving one higher dose of radiation is as good at treating the tumor in the patient's spine after surgery as giving three lower doses of radiation.


Eligibility criteria: Inclusion Criteria:

* Histologically diagnosed metastatic cancer (Diagnosis made or confirmed at MSKCC for MSKCC participants. Institutional pathologic determination accepted from participating multicenter sites.)
* Age ≥18 years
* Life expectancy ≥3 months
* ECOG ≤ 3
* Spinal surgery carried out with the goal of spinal cord decompression and spinal stabilization within 8 weeks
* Post-operative CT myelogram or MRI perfusion with evidence of separation of tumor and the spinal cord It should be noted that patients with multiple lesions will be eligible as long as there are no overlapping fields of radiation, including at various time frames.

Exclusion Criteria:

* Primary spine tumor
* Age \< 18
* Pregnancy
* Lack of adequate (≥ 2 mm) separation between the spinal cord and the tumor on post-operative CT myelogram or MRI perfusion
* Radiosensitizing chemotherapy (taxol, taxotere, cisplatin, gemcitabine, 5-fluorouracil) given within one week of radiation treatment

Primary outcomes:
measure: Local Tumor Control Using MRI or CT
timeFrame: 2 years
Secondary outcomes:
measure: Treatment-related Toxicity Using CTCAE v4.0
timeFrame: 2 years
measure: Quality of Life Between the Two Cohorts Determined Through Patient-reported Responses of the BPI
timeFrame: 2 years
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University Medical Center
state: California
city: Baltimore
country: United States
facility: John Hopkins Medical Center
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Ilya Laufer
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03566225: Pioglitazone Versus Metformin as First Treatment in Infertile Women With Polycystic Ovary Syndrome
Official title: Combined Pioglitazone and Clomophene Citrate Versus Combined Metformin and Clomiphene Citrate as First Treatment in Infertile Women With Polycystic Ovary Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Pioglitazone
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2018-06-25
Enrollment: 400
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Participants with PCOS will be divided into two groups then each group will randomly recieve one of the following treatment

1. metformin will be adminstered in adose of 500 mg 3 times daily for 3 months to group B.
2. pioglitazone will be administered in adose of 30 mg dialy for 3 months to group A.
3. Induction of ovulation by clomiphene citate 50 mg tablets to all participants

Detailed description: Participants with PCOS will be divided into two groups then each group will randomly recieve one of the following treatment

1. metformin will be adminstered in adose of 500 mg 3 times daily for 3 months to group B.
2. pioglitazone will be administered in adose of 30 mg dialy for 3 months to group A.
3. Induction of ovulation by clomiphene citate 50 mg tablets once or twice dialy 12hours apart starting from the 3rd day of menstrual cycle and continue for five days during treatment with insulin sensitizing agents to group A and B.

Participants with oligomenorrhea will recieve two tablets of noreththisterone 5 mg tab every 12 hours for 5 days to allow for withdrawal bleeding before start ovulation induction

Eligibility criteria: Inclusion Criteria:

* women age 20_35
* BMI 18_29.9
* Women with PCOS(diagnosed by using Rotterdam criteria
* Infertility is cause for seeking tfeatment

Exclusion Criteria:

* Causes of infertility other than PCOS.
* patient refusal.
* Contraindication of any of the drugs used in the study
* Cause of oligo/anovulation other than PCOS
* Current or previous (within the last six month) use of oral contraceptives, glucocorticoids, antiandrogens, antidiabetics, antiobesity drugs or other hormonal drugs.

Primary outcomes:
measure: Clinical pregnancy rate
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams Univerisity
Study officials:
affiliation: AinShams University
name: Asmaa Salih, Resident
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01861925: Study of Clinical Performance of Corneal Topography Measurement Using an Optical Biometer
Official title: Lenstar LS 900 Topography
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Corneal Topography
Lead sponsor: Haag-Streit AG
Sponsor class: INDUSTRY
Collaborators: name: Insel Gruppe AG, University Hospital Bern
First posted: 2013-05-24
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Volunteers recruited at University Hospital

Brief summary: The purpose of this study is to quantify in-vivo repeatability of a new corneal topography measurement mode of an optical biometer, and the clinical performance of measurement in comparison to reference devices.


Eligibility criteria: Inclusion Criteria:

* 18 years or older

Exclusion Criteria:

* No corneal transplants
* No corneal scar(s)
* No acute infections of the eye
* No weak fixation
* No suspected lack of compliance
* No vulnerable population

Primary outcomes:
measure: In-vivo Repeatability of Corneal Topography Measurements With Lenstar LS 900 Topography: Sample Mean of Differences of Mean Power and Sample Mean of Std. Dev of Local Power Differences Between Two Consecutive Measurements
timeFrame: 1 day of examination
Secondary outcomes:
measure: Equivalence of Corneal Topography Measurement Between Lenstar LS 900 Topography and Atlas 9000: Sample Mean of Differences of Mean Power and Sample Mean of Std. Dev of Local Power Differences for One Measurement Per Device.
timeFrame: 1 day of examination
Other outcomes:
measure: Equivalence of Corneal Topography Measurement Between Lenstar LS 900 Topography and Atlas 9000: Sample Mean of Std. Dev. of Local Corneal Elevation Differences for One Measurement Per Device.
timeFrame: 1 day of examination
measure: Equivalence of Keratometry Radius Measurement Between Lenstar LS 900 Topography and Lenstar LS 900: Population Mean of Differences of Keratometry Radius Measurement Between Both Devices.
timeFrame: 1 day of examination
measure: Equivalence of Keratometry Axis Measurement Between Lenstar LS 900 Topography and Lenstar LS 900: Population Mean of Differences of Keratometry Axis Measurement Between Both Devices.
timeFrame: 1 day of examination
Locations:
city: Berne
country: Switzerland
facility: University Hospital Inselspital
Study officials:
affiliation: Insel Gruppe AG, University Hospital Bern
name: Beatrice Frueh, Prof. Fr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03948425: Cerebral Dynamic Perfusion Study With Spectral CT in Patients Suspected of Stroke
Official title: Cerebral Dynamic Perfusion Study With Spectral CT in Patients Suspected of Stroke
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke, Acute
Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2019-05-14
Enrollment: 28
Sex: ALL
Minimum age (years): 50
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: * Generate a dynamic mapping of the distribution of iodine within the cerebral parenchyma in the patient suspected of acute ischemic disorder with the CT spectral scanner.
* Correlate the anomalies of iodine mapping to the other parameters acquired during the classic dynamic infusion phase to define the ischemic area (MTT higher and rCBV normal) versus infarcted zone (MTT higher and rCBV decreased)


Eligibility criteria: Inclusion Criteria:

* Clinical suspicion of hyperacute stroke (6 hours after onset of symptoms)
* Age between 50 and 95 years
* Weight: between 65 and 95 kg

Exclusion Criteria:

* Documented or suspected allergy to IV iodinated contrast media
* Renal impairment with creatinine clearance \<60 ml / min
* Hemorrhagic lesions or vascular abnormalities demonstrated on CT before contrast injection

Primary outcomes:
measure: Cerebral Blood Volume (CBV)
timeFrame: from start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)
measure: Mean Transit Time (MTT)
timeFrame: rom start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)
measure: Cerebral Blood Flow (CBF)
timeFrame: rom start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)
Secondary outcomes:
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Cliniques universitaires saint Luc
Study officials:
affiliation: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
name: Emmanuel Coche, MD-PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05635825: Energy and Nutrient Profiles When Asians Transit From a Meat-based to a Plant-based Diet: A Modelling Exercise
Official title: Energy and Nutrient Profiles When Asians Transit From a Meat-based to a Plant-based Diet: A Modelling Exercise
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nutrition, Healthy
Keywords: plant-based alternative protein
Lead sponsor: Singapore Institute of Food and Biotechnology Innovation
Sponsor class: OTHER_GOV
Collaborators: name: Prince September Pte Ltd Singapore
First posted: 2022-12-02
Enrollment: 50
Sex: ALL
Minimum age (years): 21
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy Asian, non-vegetarian, literate and numerate participants aged between 21-99 years.

Brief summary: This study aims to model and present a simulation exercise to assess the nutritional effects of replacing meat-based protein with meat analogues. The hypothesis of our study is to understand if any positive or detrimental effects on nutrition and health will ensue, when people replace a meat-based diet with plant-based and alternative protein substitutes.

Detailed description: A total of up 100 participants (Chinese/Malay/Indian), non-vegetarians, aged between 21 to 99 years, literate and numerate will be recruited for this study. Participants will be required to complete a 4-day food record as part of the exercise. To ensure accuracy of food records, participants will be requested to either weigh their foods or take photographs of all food and drink consumed during the duration of the study. After all the food records have been collected, the data will be analysed using food composition tables. Nutritional profiles of all participants will be generated. Animal-based products will then be substituted with plant-based counterparts and a new nutritional profile will be generated for each participant.

Eligibility criteria: Inclusion Criteria:

* Healthy males and females
* 21-99 years old
* Non-vegetarians
* Access to smart phone devices if participants intend to use photographic methods

Exclusion Criteria:

* Non-english speaking
* Members of any vulnerable populations
* Members of the research team or their immediate family members. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted

Primary outcomes:
measure: Protein
timeFrame: 4 days
measure: Carbohydrates
timeFrame: 4 days
measure: Fats
timeFrame: 4 days
measure: Minerals
timeFrame: 4 days
measure: Dietary fibre
timeFrame: 4 days
measure: Cholesterol
timeFrame: 4 days
Secondary outcomes:
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: Clinical Nutrition Research Centre
Study officials:
References:
Clinical trial NCT03293225: Efficacy of Antihistamine Dosing-up and add-on Treatment With H2-receptor Antagonist
Official title: A Randomized Open Labeled Trial to Compare the Efficacy of Antihistamine Dosing-up and add-on Treatment With H2-receptor Antagonist in Patients With Chronic Urticaria
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Urticaria
Keywords: cu
Lead sponsor: Ajou University School of Medicine
Sponsor class: OTHER
First posted: 2017-09-26
Enrollment: 110
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Chronic urticaria in Ajou University Hospital

Brief summary: A randomized open labeled trial to compare the efficacy of antihistamine dosing-up and add-on treatment with H2-receptor antagonist in patients with chronic urticaria

Detailed description: * For four weeks
* After the researcher confirms the selection / exclusion criteria on the baseline, the UAS, K-UCT, and CU-QoL are created and randomized from the subject.
* Receive UAS, K-UCT, and CU-QoL from the subject during the last visit to assess safety

Eligibility criteria: Inclusion Criteria:

* Adolescents and adults over 12 years
* Clinical diagnosis of chronic urticaria due to wheal reaction, itching, angioedema over 6 weeks
* Antihistamine 2 or 2 kinds of treatment for more than 2 weeks even if the symptoms are not controlled
* Those who do not have other chronic skin diseases

Exclusion Criteria:

* None

Primary outcomes:
measure: Number of evaluation after 4 weeks treatment by a investigator
timeFrame: 4 weeks
Secondary outcomes:
measure: Peripheral blood eosinophil count
timeFrame: 4 weeks
measure: Number of evaluation as assessed by questionnaire
timeFrame: 4 weeks
measure: Number of urticaria control by K-UCT
timeFrame: 4 weeks
measure: Number of urticaria symptom by UAS
timeFrame: 4 weeks
measure: Quality of life of chronic urticaria by CU-QoL
timeFrame: 4 weeks
measure: Number of Patient-controlled urticaria by VAS
timeFrame: 4 weeks
measure: Number of patients using emergency medication
timeFrame: 4 weeks
measure: Comparison of Serum total IgE
timeFrame: 4 weeks
measure: Number of physiological parameter
timeFrame: 4 weeks
measure: Number of creatinine, AST/ALT
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Suwon-si
country: Korea, Republic of
facility: Ajou University Medical Hospital
Study officials:
affiliation: Ajou University
name: Youngmin Ye, Dr
role: STUDY_DIRECTOR
References:
Clinical trial NCT04692025: Study to Evaluate the Effect of Food on the Pharmacokinetics of ASC41 in Healthy Volunteers
Official title: A Randomized, Single Center, Open-label, Phase I Study to Evaluate the Effect of Food and Fasting on the Pharmacokinetics of ASC41 Tablets in Healthy Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
NAFLD
Hyperlipidemia
Keywords: Healthy Volunteers
NAFLD
NASH
Hyperlipidemia
LDL-C
Lead sponsor: Ascletis Pharma Inc
Sponsor class: INDUSTRY
Collaborators: name: Hunan Provincial People's Hospital
First posted: 2020-12-31
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This study is to evaluate the effect of food on the pharmacokinetics of a single dose of ASC41 tablet in healthy volunteers, comparing fasting and postprandial pharmacokinetic parameters of Tmax, Cmax, AUC0-t, AUC0-∞.


Eligibility criteria: Key Inclusion Criteria:

* 19kg/m2 ≤ BMI \<40kg/m2.

Key Exclusion Criteria:

* A history of thyroid disease.
* History of, or current liver disease.

Primary outcomes:
measure: AUC of ASC41
timeFrame: Up to 19 days
measure: Cmax of ASC41
timeFrame: Up to 19 days
Secondary outcomes:
measure: t1/2 of ASC41
timeFrame: Up to 19 days
measure: CL/F of ASC41
timeFrame: Up to 19 days
measure: Vd/F of ASC41
timeFrame: Up to 19 days
measure: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
timeFrame: Up to 19 days
Other outcomes:
Locations:
city: Changsha
country: China
facility: Hunan provincial people's hospital
state: Hunan
Study officials:
References:
Clinical trial NCT02657525: Acute Exacerbation of Chronic Obstructive Pulmonary Disease Inpatient Registry Study
Official title: Acute Exacerbation of Chronic Obstructive Pulmonary Disease Inpatient Registry Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Lead sponsor: China-Japan Friendship Hospital
Sponsor class: OTHER
Collaborators: name: Peking University
name: China Soong Ching Ling Foundation
First posted: 2016-01-18
Enrollment: 7600
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: AECOPD-IRS plans to enroll 7600 hospitalized patients (≥ 18 years old with main diagnosis as AECOPD). Sample size estimation is based on estimated mortality of AECOPD hospitalized patients (\~5%). Study patients will be recruited from 40-60 hospitals across China,each hospital will recruit 152-190 patients. Hospital selection follows a multi-stage sampling strategy.

Brief summary: The purpose of this study is to investigate the demographic characteristics, clinical features, diagnoses and treatments of AECOPD hospitalized patients in China, and disease prognosis and its economic burden.


Eligibility criteria: Inclusion Criteria:

≥18 years of age; hospitalized patients with main diagnosis as AECOPD.

Exclusion Criteria:

Patients diagnosed as active pulmonary tuberculosis, or acute left heart failure; Patients participating in clinical trials or intervention studies of drugs.

Primary outcomes:
measure: In-hospital mortality
timeFrame: 12 months
measure: Readmission
timeFrame: 12 months
Secondary outcomes:
measure: All-cause and cause-specific mortality
timeFrame: 3 years
measure: Recurrence of acute exacerbation of COPD
timeFrame: 3 years
measure: Lung function and quality of life assessment
timeFrame: 3 years
measure: Healthcare costs
timeFrame: 12 months
Other outcomes:
Locations:
Study officials:
References: