Clinical trial NCT06039969: Evaluate Aerobic Exercise on Myocardial Fibrosis and Intestinal Flora in Dilated Cardiomyopathy Diagnosed First Time.
Official title: Study on the Changes of Intestinal Flora and Cardiac Fibrosis in Patients With Dilated Cardiomyopathy Diagnosed for the First Time by Sports Rehabilitation
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cardiac Rehabilitation
Myocardial Fibrosis
Keywords: Aerobic exercise rehabilitation
Myocardial Fibrosis
human gut microbiome
cardiac magnetic resonance
Lead sponsor: Nanjing Medical University
Sponsor class: OTHER
First posted: 2023-09-15
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who were hospitalized for heart failure for the first time and were finally diagnosed with dilated cardiomyopathy

Brief summary: To invegstive the Changes of Intestinal Flora and the improvements of Cardiac Fibrosis in Patients With Dilated Cardiomyopathy Diagnosed for the First Time by heart Rehabilitation

Detailed description: Previous studies have confirmed that Aerobic exercise rehabilitation can reduce the rate of readmission of patients with heart failure and improve their cardiopulmonary endurance and exercise ability. However, whether aerobic exercise rehabilitation can inhibit myocardial fibrosis or delay the progress of fibrosis in patients with heart failure has not been reported. At the same time, some studies have shown that the change of intestinal microbial flora may promote the progress of heart failure, and regular aerobic exercise will also lead to the change of intestinal microbial flora, but whether aerobic exercise rehabilitation can improve intestinal microbial flora in patients with dilated cardiomyopathy has not been reported. In our study, patients who were hospitalized for heart failure for the first time and were finally diagnosed with dilated cardiomyopathy were recruited. Recruited patients will enter the routine cardiac rehabilitation process and make an individualized aerobic exercise plan according to the cardiopulmonary exercise test. Cardiac MRI and intestinal microflora changes will be evaluated.

Eligibility criteria: Inclusion Criteria:

* 1、Patients hospitalized for the first time because of heart failure 2、The patient who was definitely diagnosed as dilated cardiomyopathy for the first time

Exclusion Criteria:

* 1、Other types of cardiomyopathy 2、Has been diagnosed as dilated cardiomyopathy. 3、malignant tumor 4、acute infection 5、Cannot perform cardiopulmonary exercise test.

Primary outcomes:
measure: myocardial fibrosis
timeFrame: first admission six months one year
Secondary outcomes:
measure: Bacterial spectrum of intestine
timeFrame: first admission six months one year
Other outcomes:
measure: cardiac fitiness
timeFrame: first admission six months one year
Locations:
city: Huai'an
country: China
facility: Huai'An First People'S Hospital
state: Jiangsu
Study officials:
affiliation: Huai'an First People's Hospital
name: XiWen Zhang, MD
role: STUDY_DIRECTOR
References: