louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06134089: Evaluating Online Messages About Colon Cancer Screening
Official title: Evaluating Online Messages About Colon Cancer Screening
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Colonic Cancer
Lead sponsor: University of Utah
Sponsor class: OTHER
First posted: 2023-11-18
Enrollment: 2186
Sex: ALL
Minimum age (years): 45
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Participants will be White (n=1,000) and Black (n=1,000) Americans between the ages of 45 and 74. The goal of the study is to determine if there are differences in message preferences and evaluations between these two groups due to historical disparities in colorectal cancer screening uptake and outcomes.

Brief summary: The goal of the study is to determine, using a choice-based approach, what messages (pulled from various online sites) people find more and less persuasive and shareable on the topic of colorectal cancer screening. As a secondary goal, the study is interested how various information behaviors, such as people's self-reported seeking of health information and encountering of health information, demographic variables, individual difference variables, and message exposure associate with their intentions to adhere to recommended colorectal cancer screening guidelines from the National Cancer Institute. The study is interested at differences specifically among Black and White Americans of recommended screening age (45-74).


Eligibility criteria: Inclusion Criteria:

* Identify as white/Caucasian or Black/African American.

Exclusion Criteria:

* Do not identify as white/Caucasian or Black/African American.
* Previously diagnosed with colorectal cancer

Primary outcomes:
measure: Number of messages generated by participants
timeFrame: 15 minutes
Secondary outcomes:
measure: Intentions to follow screening recommendations in the future
timeFrame: 15 minutes
Other outcomes:
Locations:
city: Salt Lake City
country: United States
facility: University of Utah Hospital/ Huntsman Cancer Institute
state: Utah
Study officials:
affiliation: Huntsman Cancer Institute/ University of Utah
name: Andy J. King, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00367289: CT for Diagnosis of Implant Stability in Revision Arthroplasty
Official title: CT for Diagnosis of Implant Stability in Revision Arthroplasty
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hip Arthroplasty
Knee Arthroplasty
Osteolysis
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2006-08-22
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Revision hip and knee arthroplasty patients

Brief summary: All patients over 18 who undergo a revision of hip or knee arthroplasty will be included. Patients undergo a CT of the hip joint. A radiologist will mark the presence of cysts and bone loss and will assess implant stability.

After the surgery, the surgeon will fill a similar form.


Eligibility criteria: Inclusion Criteria:

* patients admitted for hip or knee revision arthroplasty
* age over 18

Exclusion Criteria:

* fractures
* dislocations

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
Study officials:
affiliation: Hadassah Medical Organization
name: Leonid Kandel, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00527189: Balance Impairment and Falls Risk in People With Lower Limb Arthritis, and Can These be Improved With Exercise?
Official title: Which Measures of Balance Best Discriminate Balance Impairment and Falls Risk in People With Lower Limb Arthritis, and Can These be Improved With Exercise?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Arthritis
Keywords: Arthritis
Exercise
Balance - Postural Control
Lead sponsor: National Ageing Research Institute, Australia
Sponsor class: OTHER
Collaborators: name: Melbourne Health
First posted: 2007-09-10
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Arthritis has been reported as a risk factor for falls. Few studies have investigated the effect of balance training on balance performance in women with lower limb arthritis. The aim of this study was to evaluate the effectiveness of a four-month individualised home exercise programme in improving gait stability and balance for women with arthritis.


Eligibility criteria: Inclusion Criteria:

* Lower limb osteoarthritis or lower limb rheumatoid arthritis

Exclusion Criteria:

Participants were excluded if they:

* Did not have lower limb arthritis,
* Were bed bound,
* Had additional co-morbidities that confer risk of falls (such as Parkinson's disease, stroke, multiple sclerosis, history of cardiac syncope, epilepsy),
* Had undergone lower limb surgery within the previous twelve months, and/or
* Had synvisc or a corticosteroid injection within the last six months.

Primary outcomes:
measure: Falls Risk Human Activity Profile Confidence Balance Measures Gait Measures
Secondary outcomes:
Other outcomes:
Locations:
city: Melbourne
country: Australia
facility: National Ageing Research Institute
state: Victoria
Study officials:
affiliation: National Ageing Research Institue, Australia
name: Keith Hill, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03596489: Objective Assessment of Sensory Nerve Fiber Sensitivity
Official title: Developing a Method to Objectively Assess Sensory Nerve Fiber Sensitivity: A Pilot Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nerve Pain
Lead sponsor: Children's National Research Institute
Sponsor class: OTHER
First posted: 2018-07-24
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy Adult Volunteers will be from within the Children's National Medical Center and the surrounding community.

Brief summary: This pilot study utilizes a unique technology to determine nerve fiber sensitivity. This will allow us to determine whether this method and device can discern changes in pain intensity and type, which is predicated on differing nerve fiber sensitivities.


Eligibility criteria: Inclusion Criteria:

1. The subject is 18 to 65 years of age
2. The subject is willing to have a tourniquet applied as part of the study
3. The subject is willing and able to provide written informed consent to the study participation
4. The subject is willing and able to comply with all study procedures

Exclusion Criteria:

1. Eye pathology precluding pupillometry
2. Subjects who have ongoing pain requiring medical attention
3. Subjects who are not normotensive
4. Subjects with peripheral vascular disease
5. Subjects who are morbidly obese (BMI \>40)
6. Subjects with diabetes or diabetic retinopathy
7. Subjects who are or may be pregnant
8. Subjects with cardiac disease
9. Subjects with neuropathic disease states

Primary outcomes:
measure: Pupillary Reflex Parameters
timeFrame: 0,5,10,15,20,25,30,35 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Washington
country: United States
facility: Children's National Health System
state: District of Columbia
Study officials:
affiliation: Children's National Health System
name: Julia C Finkel, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03946189: Comparison of the PaO2/FiO2 Ratio to Other Oxygenation Indexes for the Classification of Severity of Acute Respiratory Distress Syndrome
Official title: Comparison of the PaO2/FiO2 Ratio to Other Oxygenation Indexes for the Classification of Severity of Acute Respiratory Distress Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Lead sponsor: American University of Beirut Medical Center
Sponsor class: OTHER
First posted: 2019-05-10
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients of both gender and greater than 18 years old receiving mechanical ventilation in the ICU

Brief summary: In mechanically ventilated patients the PaO2/FiO2 ratio might not be the best reflection of the severity of ARDS. It does not incorporate variables and settings used during mechanical ventilatory support such as the positive end expiratory pressure (PEEP), inspiratory time to expiratory time ratio (Ti:Te), and the peak alveolar pressure (Palv). The aim is to identify a new oxygenation index for stratification of severity of ARDS


Eligibility criteria: Inclusion Criteria:

* Patients receiving mechanical ventilation in the Intensive Care Unit.
* Patients in whom the managing medical team requested an arterial blood gas (ABG) analysis.

Exclusion Criteria:

* Patients in whom arterial blood gas could not be obtained or not ordered.

Primary outcomes:
measure: New oxygenation index
timeFrame: Immediate
Secondary outcomes:
Other outcomes:
Locations:
city: Beirut
country: Lebanon
facility: American University of Beirut
Study officials:
References:
citation: El-Khatib MF, Bouakl IJ, Ayoub CM, Chatburn RL, Farhat H, Msheik M, Fakih MH, Hallal AH. Comparison of the Oxygenation Factor and the Oxygenation Ratio in Subjects With ARDS. Respir Care. 2020 Dec;65(12):1874-1882. doi: 10.4187/respcare.07669. Epub 2020 Jul 21.
Clinical trial NCT05836389: Long-term Results of Bilateral Thoracoscopic Ablation for Stand-alone Atrial Fibrillation
Official title: Long-term Results of Bilateral Thoracoscopic Ablation for Stand-alone Atrial Fibrillation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Atrial Fibrillation
Lead sponsor: Ospedale San Raffaele
Sponsor class: OTHER
First posted: 2023-05-01
Enrollment: 56
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who underwent isolated ablation of paroxysmal or persistent AFib with pulmonary veins isolation in bilateral thoracoscopy

Brief summary: Atrial fibrillation (AFib) represents the most frequent cardiac arrhythmia whose prevalence appears to be increasing in the general population. Furthermore, this arrhythmia determines an increased risk of neurological complications (stroke) and, consequently, of mortality and morbidity.

Currently, the first choice for the treatment of AFib is represented by the use of antiarrhythmic drugs. In patients who do not respond to pharmacological treatment, the ESC 2016 European guidelines recommend the execution of transcatheter ablation (Class I, level of evidence A). However, minimally invasive pulmonary vein isolation surgery (PVI) is recommended for subjects who are not even responsive to transcatheter ablation (Class IIa, Level of Evidence B).

Previous studies have demonstrated good short-term results of thoracoscopic AFib ablation using PVI, with a 1-year freedom from atrial fibrillation recurrence without antiarrhythmic drugs of approximately 64-73%. However, only a few authors have described the medium-long term follow-up outcomes.

The aim of this study is to report the long-term follow-up data of ablation of isolated, predominantly paroxysmal atrial fibrillation performed by isolation of the pulmonary veins by radiofrequency in bilateral thoracoscopy.


Eligibility criteria: Inclusion Criteria:

* Age between 20 and 80 years old;
* Isolated atrial fibrillation (predominantly paroxysmal);
* Patients undergoing ablation of atrial fibrillation (both paroxysmal and persistent) by isolation of the pulmonary veins by radiofrequency in thoracoscopy.

Exclusion Criteria:

* Age under 20 or over 80;
* Previous trauma/deformity of the rib cage limiting the thoracoscopic approach;
* Previous pleurisy or thoracic operations (e.g. lobectomies) conditioning the possible appearance of pleural adhesions limiting the thoracoscopic approach.

Primary outcomes:
measure: Mortality
timeFrame: through study completion, a minimum of 6 years
measure: Freedom from AFib
timeFrame: through study completion, a minimum of 6 years
Secondary outcomes:
Other outcomes:
Locations:
city: Milan
country: Italy
facility: IRCCS Ospedale San Raffaele
Study officials:
References:
Clinical trial NCT02369289: Bone Mineral Density in Israeli Female Vegans and Omnivores
Official title: Bone Mineral Density in Israeli Female Vegans and Omnivores
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Bone Mineral Density
Vegan Diet
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2015-02-23
Enrollment: 240
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Sampling method: NON_PROBABILITY_SAMPLE
Study population: generaly healthy vegan and omnivore females, age 30-45

Brief summary: A vegan diet is more and more prevalent in the general population in Israel in recent years. There have been some concerens that a vegan diet may lack in bone-health related nutrients (such as calcium, protein and vitamin D), and therefore may cause a decreased bone mineral density. The study aims to compare bome mineral density and other biochemical bone health parameters in vegan and omnivore non-menopausal Israely females.


Eligibility criteria: Inclusion Criteria:

* generaly healthy
* vegan group: vegan diet for the past 3 years
* omnivore group: comsumption of animal products at least 3 times a week

Exclusion Criteria:

* pragnent / breastfeeding women
* amenorrhea (absence of a menstrual period) for more than 3 months
* amenorrhea in the past
* significant underweight in the present/past (BMI \< 17.5)
* taking medicine that affect bone density
* hypo/hyper thyroidism
* hypo/hyper parathyroidism
* smokimg in the past 10 years
* over consumption of alcohol (more than 7 units a week)

Primary outcomes:
measure: bone mineral density
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Tel Aviv
country: Israel
facility: Clinical Nutrition Unit, Sourasky Medical Center
Study officials:
References:
Clinical trial NCT00205829: Bion for Occipital Nerve Stimulation
Official title: Bion for Occipital Nerve Stimulation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Chronic Headaches
Keywords: Chronic headaches
greater occipital nerve stimulation
Lead sponsor: Boston Scientific Corporation
Sponsor class: INDUSTRY
First posted: 2005-09-21
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a prospective, single-centre, cross-over study designed to evaluate the safety and efficacy of using the bion, an implantable medical device, for the treatment of chronic headaches. The clinical study is proposed to determine the anticipated adverse event rate and treatment outcomes at the conclusion of the study. Each trial subject will serve as his/her own control.


Eligibility criteria: Inclusion Criteria:

1. Be diagnosed with chronic migraine or primary chronic daily headache
2. Have headaches characterized by pain
3. Be 18 years of age or older;
4. Be willing and able to follow all study-related procedures during course of study;
5. Have exhibited refractoriness to two acute medication regimens and two prophylactic medications from two separate preventive classes.

Exclusion Criteria:

1. Have received a botulinum toxin (botox) injection for treatment of headache within the last 90 days;
2. Have previously undergone destructive ganglionectomy
3. Have had a previous surgery in the intended implant area;
4. Have Arnold-Chiari malformation;
5. Have participated within the last 30 days or plan to participate during this study in another device or drug trial;
6. Be pregnant or planning on becoming pregnant during the study period;
7. Have an implanted electrical device (e.g., pacemaker, spinal cord stimulator) that may interfere with this therapy;
8. Demonstrate significant psychological signs, substance abuse symptoms, or behavioral problems on examination and/or history that, in the investigator's judgment, render them inappropriate for the study;
9. Currently require, or be likely to require, diathermy;
10. Have other medical conditions that the investigator believes would confound the study.

Primary outcomes:
measure: Demonstrate acceptable rate of adverse events.
timeFrame: Throughout the Study
measure: The primary efficacy measure is a significant reduction in either headache frequency or severity
timeFrame: 4 months Post-Activation Visit
Secondary outcomes:
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: University College London - Institute of Neurology
Study officials:
affiliation: University College London Hospitals
name: Peter J. Goadsby, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04634929: Endocrinological and Neuronal Aspects of Bariatric Surgery
Official title: Changes in Endocrinological and Central Neuronal Satiety Regulation Following Bariatric Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Bariatric Surgery
Obesity
Keywords: fMRI
hormonal satiety signaling
hypothalamus
weight loss
Lead sponsor: University of Heidelberg Medical Center
Sponsor class: OTHER
First posted: 2020-11-18
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: healthy participants with obesity

Brief summary: The overall aim of the proposed project is to investigate the contribution of changes in neuronal food processing, hypothalamic reactivity and hormonal factors to weight loss after bariatric surgery.


Eligibility criteria: Inclusion Criteria:

* planning to undergo bariatric surgery
* planning to take part in a conservative diet

Exclusion Criteria:

* inability to undergo fMRI
* psychiatric disorders
* metabolic disorders

Primary outcomes:
measure: Change in Functional magnetic resonance imaging following intravenous glucose infusion.
timeFrame: 2 weeks before surgery or start of dietary intervention and 2 weeks after surgery or start of dietary intervention.
measure: Experimental functional magnetic resonance imaging task (gustatory stimulation).
timeFrame: 2 weeks before surgery or start of dietary intervention and 2 weeks after surgery or start of dietary intervention.
measure: Assessment of glucose-induced changes in peripheral ghrelin using blood samples.
timeFrame: 15 minutes before and 15 minutes after functional magnetic resonance imaging
Secondary outcomes:
Other outcomes:
measure: Weight change
timeFrame: 12 months
Locations:
city: Heidelberg
country: Germany
facility: University Hospital Heidelberg
Study officials:
affiliation: Department of General, Visceral, and Transplantation Surgery, University of Heidelberg
name: Adrian Billeter, PD, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01243229: Genetic Analysis of Congenital Diaphragmatic Disorders
Official title: Genetic Analysis of Congenital Diaphragmatic Disorders
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Congenital Diaphragmatic Hernia
Congenital Diaphragmatic Eventration
Congenital Hiatal Hernia
Congenital Diaphragmatic Disorders
Lead sponsor: University of Utah
Sponsor class: OTHER
First posted: 2010-11-18
Enrollment: 305
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Newborns, children and adults affected by congenital disorders of the diaphragm, such as congenital diaphragmatic hernia, eventration and hiatal hernia.

Brief summary: The purpose of this study is to understand the genetic causes of congenital diaphragmatic disorders (CDD), namely congenital diaphragmatic hernia (CDH), eventration and hiatal hernia.

Specifically, the investigators plan to:

1. Ascertain informative families and sporadic cases with congenital diaphragmatic disorders and obtain appropriate phenotypic data and genetic material (peripheral blood and/or diaphragm tissue sample).
2. Localize the gene(s) for CDD to specific chromosomal segments using linkage analysis, and determine the role of somatic mutations in CDD.
3. Isolate and characterize genes involved in the pathogenesis of CDD.
4. Develop molecular markers that will facilitate accurate diagnosis (including prenatal diagnosis) and permit correlation of phenotypic variation with specific mutations.
5. Compare RNA-sequencing from tissue samples of children without CDH to those children with CDH.


Eligibility criteria: Inclusion Criteria:

* Diagnosed with a congenital diaphragmatic disorder

Exclusion Criteria:

* none

Primary outcomes:
measure: Genes implicated in CDD can be identified by linkage analysis
timeFrame: 5 years
Secondary outcomes:
measure: Develop molecular markers that will facilitate accurate diagnosis of CDD and CDH.
timeFrame: 5 years
Other outcomes:
Locations:
city: Salt Lake City
country: United States
facility: Primary Children's Medical Center
state: Utah
city: Salt Lake City
country: United States
facility: University Hospital
state: Utah
Study officials:
affiliation: University of Utah
name: Luca Brunelli, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04185129: Comparison Efficacy in Patients With Asthma Using Foster MDI and Relvar Medications
Official title: Comparison Efficacy in Patients With Asthma Using Foster MDI and Relvar Medications
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Asthma
Lead sponsor: Far Eastern Memorial Hospital
Sponsor class: OTHER
Collaborators: name: Orient Europharma Co., Ltd.
First posted: 2019-12-04
Enrollment: 200
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a randomized study to compare asthma patients using Foster or Relvar.

Detailed description: The Global Asthma Association (GAA) and the World Allergy Organization (WAO) recently issued statements stating that the small airway is caused by asthma and chronic obstructive pulmonary disease (COPD). Both pathogenesis and treatment play an important role. The small airway is an airway with diameter less than 2 mm and is one of the main sites where airflow obstruction occurs. Small particles (\<2 μm) and large particles are more likely to deposit in the distal airways, and have shown to have better effects on asthma and pulmonary obstruction. At the same time, real-life research has also shown that extra-fine particles provide better asthma control than large particles, and can better improve quality of life.The aim of the study is to compare the efficacy of asthma inhalers between extra-fine particles and non-extra-fine particles.

Eligibility criteria: Inclusion Criteria:

* patients diagnosis with asthma with treatment naive
* asthma patients with poor controlled status

Exclusion Criteria:

* COPD
* smoking history
* pregnancy
* cardiaovascular disease
* patients with acute respiratory infection

Primary outcomes:
measure: Lung function improvement
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Far Eastern Memorial Hospital
Study officials:
affiliation: Far Eastern Memorial Hospital
name: Shih-Lung Cheng
role: PRINCIPAL_INVESTIGATOR
References: