Clinical trial NCT05110365: Effect of Proprioceptive Neuromuscular Facilitation on Blood Pressure
Official title: Effects of Proprioceptive Neuromuscular Facilitation Exercise on Blood Pressure and Ankle Brachial Index in Patient With Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Keywords: proprioceptive neuromuscular facilitations
ankle brachial index
diabetes
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2021-11-05
Enrollment: 24
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To determine the effect of Proprioceptive Neuromuscular Facilitation exercise on blood pressure in patient with mild to moderate hypertension.Both genders will be included.Patients aged between 40 and 60 years with mild and moderate hypertension.Systolic blood pressure 130-160 mmHg or Diastolic Blood Pressure 80-100 mmHg.

Sphygmomanometer and EuroQoL five-dimensional instrument would be used for the 'Pre' \& 'Post' assessment.

Detailed description: There is a belief that proprioceptive neuromuscular facilitation exercises cause cardiac overload as blood pressure in immediately influenced by exercise but Pereira concluded in his research that proprioceptive neuromuscular facilitation exercises with minimum repetitions are safe for hypertensive or cardiovascular patients because in his study there is no increase in blood pressure in older women after performing three different types of PNF exercises. Pereira discovered that rhythmic initiation , dynamic reversals , and combination of isotonic techniques did not raise blood pressure levels, thus it is recommended to use up to five repeats of repetition maximum . One study observed at the effects of passive and modified proprioceptive neuromuscular facilitation (PNF)stretching techniques on acute systolic and diastolic blood pressure responses. All PNF treatments were beneficial in increasing Range of motion, as we all know.

PNF improves Range Of Motion while avoiding an increase in Systolic blood pressure in one or two trials, but increases Systolic blood pressure in a third trial. Blood pressure rises by 40% with conventional exercise programmers and because PNF involves near-maximal resistance,researchers anticipated a considerable rise in blood pressure during PNF execution. It was discovered that elderly subjects could not readily execute more than five to seven repetitions of PNF exercises, which has also been shown by others. Due to the low repetition number of each movement pattern, the results showed that PNF did not induce a high enough workload to increase blood pressure in the elderly.

Eligibility criteria: Inclusion Criteria:

* Both genders will be included.
* Patients aged between 40 and 60 years with mild and moderate hypertension.
* Systolic blood pressure 130-160 mmHg or Diastolic blood pressure 80-100 mmHg.
* Mild and moderate hypertension with diabetes

Exclusion Criteria:

* Severe hypertensive patients.
* Patient on smoking
* Patient with severe complications and comorbidities.
* Not willing to give consent/ data

Primary outcomes:
measure: sphygmomanometer
timeFrame: 12 weeks
Secondary outcomes:
measure: (EuroQoL five-dimensional instrument )
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Abbottābād
country: Pakistan
facility: Valley Medical Complex Abbottabad
state: Kpk
Study officials:
affiliation: Riphah International University
name: sania aziz, MSNMPT
role: PRINCIPAL_INVESTIGATOR
References:
citation: Linke A, Erbs S, Hambrecht R. Effects of exercise training upon endothelial function in patients with cardiovascular disease. Front Biosci. 2008 Jan 1;13:424-32. doi: 10.2741/2689.
citation: Papaioannou TG, Oikonomou E, Lazaros G, Christoforatou E, Vogiatzi G, Tsalamandris S, Chasikidis C, Kalambogias A, Mavratzas T, Stofa E, Mystakidi VC, Latsios G, Deftereos S, Tousoulis D. Arterial stiffness and subclinical aortic damage of reclassified subjects as stage 1 hypertension according to the new 2017 ACC/AHA blood pressure guidelines. Vasa. 2019 May;48(3):236-243. doi: 10.1024/0301-1526/a000765. Epub 2018 Dec 10.
citation: Varounis C, Katsi V, Nihoyannopoulos P, Lekakis J, Tousoulis D. Cardiovascular Hypertensive Crisis: Recent Evidence and Review of the Literature. Front Cardiovasc Med. 2017 Jan 10;3:51. doi: 10.3389/fcvm.2016.00051. eCollection 2016.
citation: Singh S, Shankar R, Singh GP. Prevalence and Associated Risk Factors of Hypertension: A Cross-Sectional Study in Urban Varanasi. Int J Hypertens. 2017;2017:5491838. doi: 10.1155/2017/5491838. Epub 2017 Dec 3.
citation: Papadopoulos DP, Sanidas EA, Viniou NA, Gennimata V, Chantziara V, Barbetseas I, Makris TK. Cardiovascular hypertensive emergencies. Curr Hypertens Rep. 2015 Feb;17(2):5. doi: 10.1007/s11906-014-0515-z.
citation: Hindle KB, Whitcomb TJ, Briggs WO, Hong J. Proprioceptive Neuromuscular Facilitation (PNF): Its Mechanisms and Effects on Range of Motion and Muscular Function. J Hum Kinet. 2012 Mar;31:105-13. doi: 10.2478/v10078-012-0011-y. Epub 2012 Apr 3.
citation: Kim EK, Lee DK, Kim YM. Effects of aquatic PNF lower extremity patterns on balance and ADL of stroke patients. J Phys Ther Sci. 2015 Jan;27(1):213-5. doi: 10.1589/jpts.27.213. Epub 2015 Jan 9.
citation: Pereira MP. Proprioceptive neuromuscular facilitation does not increase blood pressure of healthy elderly women. Physiother Theory Pract. 2012 Jul;28(5):412-6. doi: 10.3109/09593985.2011.609582. Epub 2011 Oct 18.
citation: Fagard RH, Cornelissen VA. Effect of exercise on blood pressure control in hypertensive patients. Eur J Cardiovasc Prev Rehabil. 2007 Feb;14(1):12-7. doi: 10.1097/HJR.0b013e3280128bbb.