Clinical trial NCT03452735: Fertility Study of Women With Chronic Inflammatory Rheumatism
Official title: Fertility Study of Women With Chronic Inflammatory Rheumatism
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Arthritis, Psoriatic
Arthritis, Rheumatoid
Ankylosing Spondylitis
Chronic Juvenile Arthritis
Keywords: Chronic inflammatory rheumatism
Fertility
Procreation
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2018-03-02
Enrollment: 2900
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: * Case group: patient with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis, Chronic juvenile arthritis
* Control Group: patient not suffering from RIC, having consulted in rheumatology for a mechanical pathology (eg osteoarthritis, mechanical low back pain ...)

Brief summary: Etiopathogenesis of Chronic inflammatory rheumatisms (CIR) includes genetic, autoimmune and environmental factors. Their impact on the quality of life is important, leading to a sometimes severe disability. Thus they are likely to affect female fertility through several mechanisms, including autoimmune since the association between immunity and fertility has already been demonstrated in other autoimmune diseases.

This study wants to evaluate and compare the birth rate between CIR and control group.

Detailed description: Data collection will be carried out using a questionnaire submitted to women in charge of the rheumatology department of the University Hospital of Toulouse and having agreed to participate:

* women with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis or Chronic juvenile arthritis for the chronic inflammatory rheumatism group
* women with a mechanical rheumatic pathology for the control group

The primary endpoint was birth rate after spontaneous or induced pregnancy in patients who attempted to procreate, in the CIR group and in the control group.

Eligibility criteria: Inclusion Criteria:

* Patient with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis, Chronic juvenile arthritis, Chronic Inflammatory Rheumatism
* Patient diagnosed before the age of 40
* Patient having given her no opposition to her participation in research
* For the control group: patient not suffering from chronic inflammatory rheumatism, having consulted in Rheumatology for a mechanical pathology

Exclusion Criteria:

* Patient\> 40 years old at the time of diagnosis
* Patient with insufficient medical data (treatments)

Primary outcomes:
measure: Birth rate after spontaneous or induced pregnancy
timeFrame: One day
Secondary outcomes:
measure: Rates of ectopic pregnancy, early or late spontaneous miscarriage
timeFrame: one day
measure: Design time
timeFrame: One day
measure: Birth rate according to the treatments used
timeFrame: One day
measure: Birth rate according to the activity of the disease
timeFrame: One day
measure: Rates of desire for pregnancy
timeFrame: One day
measure: Rates of sexual dysfunction
timeFrame: One day
Other outcomes:
Locations:
city: Toulouse
country: France
facility: University Hospital Toulouse
Study officials:
affiliation: University Hospital, Toulouse
name: Jean Parinaud, MD
role: PRINCIPAL_INVESTIGATOR
References: