Clinical trial NCT03539744: A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.
Official title: A Phase 3, Multicenter, Randomized, Open Label Study of Venetoclax and Dexamethasone Compared With Pomalidomide and Dexamethasone in Subjects With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Multiple Myeloma
Keywords: Cancer, Multiple Myeloma (MM), Relapsed or Refractory Multiple Myeloma (R/R MM), pharmacokinetics
CANOVA
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
Collaborators: name: Roche-Genentech
First posted: 2018-05-29
Enrollment: 265
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A study designed tocompare progression-free survival (PFS) in participants with t(11;14)-positive MM treated with venetoclax in combination with dexamethasone versus pomalidomide in combination with dexamethasone.


Eligibility criteria: Inclusion Criteria:

* Documented diagnosis of multiple myeloma (MM) based on standard International Myeloma Working Group (IMWG) criteria.
* Measurable disease at screening as defined per protocol.
* Has received at least 2 prior lines of therapy as described in the protocol.
* Has had documented disease progression on or within 60 days after completion of the last therapy.
* Has received at least 2 consecutive cycles of lenalidomide and be relapsed/refractory to lenalidomide, as defined per protocol.
* Has received at least 2 consecutive cycles of a proteasome inhibitor (PI).
* Has t(11;14)-positive status determined by an analytically validated fluorescent in situ hybridization (FISH) assay per centralized laboratory testing.
* An Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2.
* Laboratory values (liver, kidney and hematology laboratory values) that meet criteria as described per protocol.

Exclusion Criteria:

* History of treatment with venetoclax or another B-Cell Lymphoma (BCL)-2 inhibitor or pomalidomide.
* History of other active malignancies, including myelodysplastic syndromes (MDS), within the past 3 years (exceptions described in the protocol).
* Evidence of ongoing graft-versus-host disease (GvHD) if prior stem cell transplant (SCT).
* Prior treatment with any of the following: allogeneic or syngeneic SCT within 16 weeks prior to randomization; or autologous SCT within 12 weeks prior to randomization.
* Known central nervous system involvement of MM.
* Concurrent conditions as listed in the protocol.

Primary outcomes:
measure: Progression-Free Survival (PFS)
timeFrame: Up to approximately 43 months from first randomization
Secondary outcomes:
measure: Overall Response Rate (ORR)
timeFrame: Up to approximately 43 months from first randomization
measure: Very Good Partial Response or Better Response Rate (VGPR)
timeFrame: Up to approximately 43 months from first randomization
measure: Overall survival (OS)
timeFrame: Up to approximately 51 months from first randomization
measure: Minimal Residual Disease (MRD) Negativity Rate
timeFrame: Up to approximately 43 months from first randomization
measure: Time to Deterioration in Disease Symptoms
timeFrame: Up to approximately 51 months from first randomization
measure: Time to Deterioration in Physical Functioning
timeFrame: Up to approximately 51 months from first randomization
measure: Change from Baseline in PROMIS Fatigue Score
timeFrame: Up to approximately 51 months from first randomization
measure: Change from Baseline in BPI-SF Worst Pain Score
timeFrame: Up to approximately 51 months from first randomization
measure: Change from Baseline in EuroQoL 5 Dimension 5 Level (EQ-5D-5L)
timeFrame: Up to approximately 51 months from first randomization
measure: Change from Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30)
timeFrame: Up to approximately 51 months from first randomization
measure: Change from Baseline in European Organization for Research and Treatment of Cancer Quality of Life Multiple Myeloma Module 20 (EORTC QLQ-MY20)
timeFrame: Up to approximately 51 months from first randomization
measure: Duration of response (DOR)
timeFrame: Up to approximately 43 months from first randomization
measure: Time to Disease Progression (TTP)
timeFrame: Up to approximately 43 months from first randomization
measure: Time to Response (TTR)
timeFrame: Up to approximately 43 months from first randomization
measure: Cmax of Venetoclax
timeFrame: Up to approximately 225 days from initial dose
measure: Trough Concentration (Ctrough) of Venetoclax
timeFrame: Up to approximately 225 days from initial dose
measure: Number of Participants With Adverse Events (AEs)
timeFrame: Up to approximately 51 months from first randomization
Other outcomes:
Locations:
city: Tucson
country: United States
facility: Duplicate_University of Arizona Cancer Center - North Campus /ID# 218407
state: Arizona
city: Fresno
country: United States
facility: VA Central California Health Care System /ID# 200047
state: California
city: Los Angeles
country: United States
facility: University of California, Los Angeles /ID# 171524
state: California
city: Aurora
country: United States
facility: Rocky Mountain Regional VA Medical Center/Eastern Colorado Health Care System /ID# 222904
state: Colorado
city: Jacksonville
country: United States
facility: Mayo Clinic /ID# 200075
state: Florida
city: Weston
country: United States
facility: Cleveland Clinic Florida /ID# 208884
state: Florida
city: Louisville
country: United States
facility: Duplicate_Norton Cancer Institute /ID# 200834
state: Kentucky
city: Baltimore
country: United States
facility: University of Maryland, Baltimore /ID# 217422
state: Maryland
city: Boston
country: United States
facility: Boston Medical Center /ID# 223606
state: Massachusetts
city: Detroit
country: United States
facility: Barbara Ann Karmanos Cancer In /ID# 201377
state: Michigan
city: Detroit
country: United States
facility: Duplicate_Henry Ford Hospital /ID# 171531
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic - Rochester /ID# 201091
state: Minnesota
city: New York
country: United States
facility: Columbia University Medical Center /ID# 200715
state: New York
city: Cleveland
country: United States
facility: Fairview Hospital - Moll Pavilion /ID# 208919
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Main Campus /ID# 202247
state: Ohio
city: Pittsburgh
country: United States
facility: UPMC Hillman Cancer Ctr /ID# 200063
state: Pennsylvania
city: Houston
country: United States
facility: MD Anderson Cancer Center at Texas Medical Center /ID# 200060
state: Texas
city: Salt Lake City
country: United States
facility: Huntsman Cancer Institute /ID# 218406
state: Utah
city: Seattle
country: United States
facility: VA Puget Sound Health Care System /ID# 222708
state: Washington
city: Liverpool
country: Australia
facility: Liverpool Hospital /ID# 202431
state: New South Wales
city: Wahroonga
country: Australia
facility: Sydney Adventist Hospital /ID# 222874
state: New South Wales
city: Wollongong
country: Australia
facility: Wollongong Hospital /ID# 205545
state: New South Wales
city: Hyde Park
country: Australia
facility: ICON Cancer Care - Townsville /ID# 206565
state: Queensland
city: South Brisbane
country: Australia
facility: Icon Cancer Centre /ID# 205663
state: Queensland
city: Woodville South
country: Australia
facility: The Queen Elizabeth Hospital /ID# 202432
state: South Australia
city: Nedlands
country: Australia
facility: Perth Blood Institute Ltd /ID# 206649
state: Western Australia
city: Calgary
country: Canada
facility: Arthur J. E. Child Comprehensive Cancer Centre /ID# 218846
state: Alberta
city: Vancouver
country: Canada
facility: BC Cancer - Vancouver /ID# 222804
state: British Columbia
city: Halifax
country: Canada
facility: Queen Elizabeth II Health Sciences Centre - Victoria General /ID# 218883
state: Nova Scotia
city: Levis
country: Canada
facility: CISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 218887
state: Quebec
city: Beijing
country: China
facility: Beijing Chaoyang Hospital,Capital Medical University /ID# 216014
state: Beijing
city: Beijing
country: China
facility: Peking University Third Hospital /ID# 216371
state: Beijing
city: Beijing
country: China
facility: Peking Union Medical College Hospital (East) - Dongdan Campus /ID# 216040
state: Beijing
city: Guangzhou
country: China
facility: Sun Yat-Sen University Cancer Center /ID# 223828
state: Guangdong
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital /ID# 215860
state: Guangdong
city: Zhengzhou
country: China
facility: Henan Cancer Hospital /ID# 215987
state: Henan
city: Wuhan
country: China
facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 215850
state: Hubei
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital /ID# 223143
state: Jiangsu
city: Suzhou
country: China
facility: The First Affiliated Hospital of Soochow University /ID# 216094
state: Jiangsu
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University /ID# 216954
state: Jiangxi
city: Shenyang
country: China
facility: The First Hospital of China Medical University /ID# 215996
state: Liaoning
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University /ID# 223435
state: Liaoning
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 216643
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Tongji Hospital /ID# 218865
state: Shanghai
city: Chengdu
country: China
facility: West China Hospital, Sichuan University /ID# 216647
state: Sichuan
city: Tianjin
country: China
facility: Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 216041
state: Tianjin
city: Tianjin
country: China
facility: Tianjin Medical University Cancer Institute & Hospital /ID# 223550
state: Tianjin
city: Hangzhou
country: China
facility: The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 215989
state: Zhejiang
city: Hangzhou
country: China
facility: The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 218691
state: Zhejiang
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University /ID# 218953
state: Zhejiang
city: Beijing
country: China
facility: Beijing Chaoyang Hospital, Capital Medical University(West campus) /ID# 234033
city: Brno
country: Czechia
facility: Fakultní Nemocnice Brno - Jihlavská /ID# 204512
state: Brno-mesto
city: Hradec Králové
country: Czechia
facility: Fakultní nemocnice Hradec Králové - Sokolská /ID# 221291
state: Hradec Kralove
city: Ostrava
country: Czechia
facility: Fakultni Nemocnice Ostrava /ID# 204515
state: Ostrava-mesto
city: Olomouc
country: Czechia
facility: Fakultni nemocnice Olomouc /ID# 221290
city: Praha
country: Czechia
facility: Vseobecna fakultni nemocnice v Praze /ID# 221166
city: Herlev
country: Denmark
facility: Duplicate_Herlev Hospital /ID# 223221
state: Hovedstaden
city: Aalborg
country: Denmark
facility: Aalborg University Hospital /ID# 223220
state: Nordjylland
city: Odense
country: Denmark
facility: Odense University Hospital /ID# 223217
state: Syddanmark
city: Vejle
country: Denmark
facility: Sygehus Lillebalt, Vejle /ID# 223216
state: Syddanmark
city: Roskilde
country: Denmark
facility: Duplicate_Roskilde Hospital /ID# 223366
city: Paris Cedex 13
country: France
facility: Hopital Pitie Salpetriere /ID# 214173
state: Ile-de-France
city: La Tronche
country: France
facility: Duplicate_CHU Grenoble - Hopital Michallon /ID# 223182
state: Isere
city: Reims CEDEX
country: France
facility: CHU Reims - Hôpital Robert Debre /ID# 233907
state: Marne
city: Vandoeuvre-les-Nancy
country: France
facility: CHRU Nancy - Hopitaux de Brabois /ID# 201076
state: Meurthe-et-Moselle
city: Lille
country: France
facility: CHRU Lille - Hopital Claude Huriez /ID# 202213
state: Nord
city: Creteil
country: France
facility: Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 202211
state: Paris
city: Nantes
country: France
facility: CHU de Nantes, Hotel Dieu -HME /ID# 200099
state: Pays-de-la-Loire
city: Pierre Benite CEDEX
country: France
facility: HCL - Hopital Lyon Sud /ID# 200097
state: Rhone
city: Rouen
country: France
facility: Centre Henri Becquerel /ID# 223186
state: Seine-Maritime
city: Avignon CEDEX 9
country: France
facility: CH Henri Duffaut /ID# 234154
state: Vaucluse
city: Stuttgart
country: Germany
facility: Robert-Bosch-Krankenhaus /ID# 223947
state: Baden-Wuerttemberg
city: Tubingen
country: Germany
facility: Universitaetsklinikum Tuebingen /ID# 238646
state: Baden-Wuerttemberg
city: Wuerzburg
country: Germany
facility: Universitaetsklinikum Wuerzburg /ID# 200055
state: Bayern
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz gGmbH /ID# 233797
state: Sachsen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 201830
state: Schleswig-Holstein
city: Jena
country: Germany
facility: Universitaetsklinikum Jena /ID# 201254
state: Thueringen
city: Berlin
country: Germany
facility: Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 200051
city: Hamburg
country: Germany
facility: Universitaetsklinikum Hamburg-Eppendorf /ID# 215495
city: Hamburg
country: Germany
facility: Asklepios Klinik Altona /ID# 222506
city: Athens
country: Greece
facility: Alexandra General Hospital /ID# 202386
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 222879
state: Kriti
city: Athens
country: Greece
facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 213982
city: Patras
country: Greece
facility: University Gen Hosp of Patra /ID# 201691
city: Thessaloniki
country: Greece
facility: Theageneio Anticancer Hospital /ID# 213983
city: Thessaloniki
country: Greece
facility: General Hospital of Thessaloniki George Papanikolaou /ID# 201692
city: Haifa
country: Israel
facility: Rambam Health Care Campus /ID# 169678
state: H_efa
city: Haifa
country: Israel
facility: Bnai Zion Medical Center /ID# 169466
state: H_efa
city: Haifa
country: Israel
facility: The Lady Davis Carmel Medical Center /ID# 222969
state: H_efa
city: Ashdod
country: Israel
facility: Duplicate_Assuta Ashdod Medical Center /ID# 222968
state: HaDarom
city: Be'er Sheva
country: Israel
facility: Soroka University Medical Center /ID# 218768
state: HaDarom
city: Ramat Gan
country: Israel
facility: The Chaim Sheba Medical Center /ID# 169778
state: Tel-Aviv
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 169437
state: Tel-Aviv
city: Jerusalem
country: Israel
facility: Hadassah /ID# 169474
state: Yerushalayim
city: Petah Tikva
country: Israel
facility: Rabin Medical Center /ID# 244611
city: Bologna
country: Italy
facility: Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 170952
state: Emilia-Romagna
city: Torino
country: Italy
facility: A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 170962
state: Piemonte
city: Rionero In Vulture
country: Italy
facility: Irccs-Crob /Id# 170955
state: Potenza
city: Ancona
country: Italy
facility: Azienda Ospedaliero Universitaria delle Marche /ID# 170950
city: Milano
country: Italy
facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 212498
city: Palermo
country: Italy
facility: Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 222988
city: Terni
country: Italy
facility: Azienda Ospedaliera Santa Maria Terni /ID# 170948
city: Nagoya shi
country: Japan
facility: Nagoya City University Hospital /ID# 170880
state: Aichi
city: Kashiwa-shi
country: Japan
facility: The Jikei University Kashiwa Hospital /ID# 223031
state: Chiba
city: Fukuoka-shi
country: Japan
facility: Kyushu University Hospital /ID# 171117
state: Fukuoka
city: Ogaki-shi
country: Japan
facility: Ogaki Municipal Hospital /ID# 171043
state: Gifu
city: Maebashi-shi
country: Japan
facility: Gunma University Hospital /ID# 170966
state: Gunma
city: Hiroshima-shi
country: Japan
facility: Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital /ID# 171255
state: Hiroshima
city: Kobe-shi
country: Japan
facility: Kobe City Medical Center General Hospital /ID# 170992
state: Hyogo
city: Higashi Ibaraki-gun
country: Japan
facility: Duplicate_National Hospital Organization Mito Medical Center /ID# 171187
state: Ibaraki
city: Hitachi-shi
country: Japan
facility: Hitachi General Hospital /ID# 200843
state: Ibaraki
city: Shiwa-gun
country: Japan
facility: Iwate Medical University Hospital /ID# 222849
state: Iwate
city: Sendai-shi
country: Japan
facility: Tohoku University Hospital /ID# 201935
state: Miyagi
city: Okayama-shi
country: Japan
facility: Okayama Medical Center /ID# 200119
state: Okayama
city: Osaka-shi
country: Japan
facility: Japanese Red Cross Osaka Hospital /ID# 171493
state: Osaka
city: Suita-shi
country: Japan
facility: The University of Osaka Hospital /ID# 201966
state: Osaka
city: Tokushima-shi
country: Japan
facility: Tokushima University Hospital /ID# 202571
state: Tokushima
city: Minato-ku
country: Japan
facility: The Jikei University Hospital /ID# 239014
state: Tokyo
city: Shibuya-ku
country: Japan
facility: Japanese Red Cross Medical Center /ID# 171256
state: Tokyo
city: Yamagata-shi
country: Japan
facility: Yamagata University Hospital /ID# 238329
state: Yamagata
city: Incheon
country: Korea, Republic of
facility: Duplicate_Gachon University Gil Medical Center /ID# 202827
state: Gyeonggido
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital /ID# 202711
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center /ID# 202710
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St. Marys Hospital /ID# 234045
state: Seoul Teugbyeolsi
city: Ulsan
country: Korea, Republic of
facility: Ulsan University Hospital /ID# 222716
state: Ulsan Gwang Yeogsi
city: Seoul
country: Korea, Republic of
facility: Yonsei University Health System Severance Hospital /ID# 202709
city: Moscow
country: Russian Federation
facility: Moscow State budget healthcare /ID# 169685
state: Moskva
city: Novosibirsk
country: Russian Federation
facility: Research Institute of Fundamental and Clinical Immunology /ID# 223594
state: Novosibirskaya Oblast
city: Pyatigorsk
country: Russian Federation
facility: LLC Novaya Klinika /ID# 169689
state: Stavropol Skiy Kray
city: Moscow
country: Russian Federation
facility: City Clinical Hospital #52 /ID# 206289
city: Saint Petersburg
country: Russian Federation
facility: Leningrad Regional Clinical Hospital /ID# 202776
city: Sankt-Peterburg
country: Russian Federation
facility: Almazov National Medical Research Centre /ID# 169681
city: Tula
country: Russian Federation
facility: Tula Regional Clinical Hospital /ID# 223226
city: Singapore
country: Singapore
facility: National University Hospital /ID# 203988
city: Singapore
country: Singapore
facility: Singapore General Hospital /ID# 202131
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital /ID# 204374
city: Palma de Mallorca
country: Spain
facility: Hospital Universitari Son Espases /ID# 222889
state: Illes Balears
city: Marbella
country: Spain
facility: Hospital Costa del Sol /ID# 234083
state: Malaga
city: Orense
country: Spain
facility: Complejo Hospitalario Universitario Ourense /ID# 222876
state: Ourense
city: San Cristóbal de La Laguna
country: Spain
facility: Hospital Universitario Canarias /ID# 238452
state: Santa Cruz De Tenerife
city: Barcelona
country: Spain
facility: Hospital Universitario Vall d'Hebron /ID# 218106
city: Girona
country: Spain
facility: Instituto Catalan de Oncologia (ICO) Girona /ID# 171311
city: Leon
country: Spain
facility: Hospital de Leon /ID# 233878
city: Madrid
country: Spain
facility: Hospital Universitario Fundacion Jimenez Diaz /ID# 171304
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre /ID# 171288
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 218107
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca /ID# 171294
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio /ID# 171286
city: Toledo
country: Spain
facility: Hospital General Universitario de Toledo /ID# 222887
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe /ID# 234019
city: Lulea
country: Sweden
facility: Sunderby sjukhus /ID# 201314
state: Norrbottens Lan
city: Boras
country: Sweden
facility: Sodra Alvsborgs sjukhus /ID# 213061
state: Vastra Gotalands Lan
city: Linkoping
country: Sweden
facility: Duplicate_Universitetssjukhuset Linköping /ID# 200789
state: Vastra Gotalands Lan
city: Uddevalla
country: Sweden
facility: Uddevalla sjukhus /ID# 201315
state: Vastra Gotalands Lan
city: Saricam Adana
country: Turkey
facility: Cukurova Universitesi Tip Fakultesi /ID# 201955
state: Adana
city: Karsiyaka
country: Turkey
facility: Izmir Ekonomi Universitesi Ozel Medicalpoint Hastanesi /ID# 201954
state: Izmir
city: Ankara
country: Turkey
facility: Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi /ID# 201956
city: Ankara
country: Turkey
facility: Gazi University Medical Faculty /ID# 222698
city: Ankara
country: Turkey
facility: Ankara Univ Medical Faculty /ID# 201881
city: Istanbul
country: Turkey
facility: Istanbul University Istanbul Medical Faculty /ID# 201953
city: Istanbul
country: Turkey
facility: Bagcilar Medipol Mega Universite Hastanesi /ID# 222914
city: Istanbul
country: Turkey
facility: Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 201952
city: Izmir
country: Turkey
facility: Ege University Medical Faculty /ID# 222697
city: Cherkasy
country: Ukraine
facility: Communal Nonprofit Enterprise Cherkasy Regional Oncology Dispensary /ID# 223943
state: Cherkaska Oblast
city: Kharkiv
country: Ukraine
facility: Communal non-profit enterprise Regional Center of Oncology /ID# 223945
state: Kharkivska Oblast
city: Khmelnytskyi
country: Ukraine
facility: MNI Khmelnytskyi Regional Hospital of Khmelnytskyi Regional Council /ID# 223942
city: Kyiv
country: Ukraine
facility: National Cancer Institute /ID# 223944
city: Lviv
country: Ukraine
facility: SI Institute of Blood Pathology and Transfusion Medicine of NAMS of Ukraine /ID# 223941
city: Cambridge
country: United Kingdom
facility: Addenbrooke's Hospital /ID# 223097
state: Cambridgeshire
city: London
country: United Kingdom
facility: Hammersmith Hospital /ID# 171446
state: England
city: London
country: United Kingdom
facility: University College London Hospital /ID# 171428
state: Greater London
city: Norwich
country: United Kingdom
facility: Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 218213
state: Norfolk
city: Nottingham
country: United Kingdom
facility: Duplicate_Nottingham University Hospitals NHS Trust /ID# 223292
state: Nottinghamshire
city: Glasgow
country: United Kingdom
facility: Duplicate_NHS Greater Glasgow and Clyde /ID# 202199
state: Scotland
city: Stoke-on-Trent
country: United Kingdom
facility: Duplicate_University Hospitals North Midlands - Royal Stoke University Hospital /ID# 218355
state: Staffordshire
city: London
country: United Kingdom
facility: Duplicate_Duplicate_Lewisham and Greenwich NHS Trust /ID# 171445
city: Manchester
country: United Kingdom
facility: Manchester University NHS Foundation Trust /ID# 171440
city: Portsmouth
country: United Kingdom
facility: Portsmouth Hospitals University NHS Trust /ID# 171444
city: Reading
country: United Kingdom
facility: Royal Berkshire NHS Foundation Trust /ID# 217835
city: Sheffield
country: United Kingdom
facility: Duplicate_Sheffield Teaching Hospitals NHS Foundation Trust - Royal Hallamshire /ID# 171447
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: