louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01985425: Colchicine For Prevention of Perioperative Atrial Fibrillation in Patients Undergoing Thoracic Surgery Pilot Study
Official title: Colchicine For Prevention of Perioperative Atrial Fibrillation in Patients Undergoing Thoracic Surgery Pilot Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Atrial Fibrillation
Thoracic Surgery
Lead sponsor: Population Health Research Institute
Sponsor class: OTHER
Collaborators: name: Canadian Institutes of Health Research (CIHR)
First posted: 2013-11-15
Enrollment: 100
Sex: ALL
Minimum age (years): 55
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this pilot study is to determine the feasibility of comparing colchicine to placebo for the prevention of new onset atrial fibrillation in patients undergoing general thoracic surgery and establish the foundation for a large, multi-centre, clinical trial.


Eligibility criteria: Inclusion Criteria:

* All patients ≥55 years of age undergoing intra-thoracic surgery for a resection of tumor in lung.

Exclusion Criteria:

* In AF prior to surgery\*,
* Undergoing minor thoracic interventions/ procedures (i.e., chest tube insertion, needle pleural/lung biopsies, or minor chest-wall surgeries), or
* With contraindications to colchicine (i.e., allergy, or myelodysplastic disorders or estimated glomerular filtration rate \[e-GFR\] \<30 mL/min/1.73m)

  * Clarification: Patients with history of AF who are in sinus rhythm during enrollment will be eligible for recruitment. Patients who have no history of AF and are found to be in AF at the time of enrollment will not be eligible.

Primary outcomes:
measure: Clinically Significant Atrial Fibrillation
timeFrame: Post-operative Day 1 until Postoperative Day 30
Secondary outcomes:
measure: Death
timeFrame: Post-operative Day 1 until Postoperative Day 30
measure: New Onset Atrial Flutter
timeFrame: Post-operative Day 1 until Postoperative Day 30
measure: Myocardial Injury After Non-Cardiac Surgery (MINS)
timeFrame: Post-operative Day 1 until Postoperative Day 30
measure: Stroke
timeFrame: Post-operative Day 1 until Postoperative Day 30
measure: Transient Ischemic Attack (TIA)
timeFrame: Post-operative Day 1 until Postoperative Day 30
measure: Post-operative Infection
timeFrame: Post-operative Day 1 until Postoperative Day 30
Other outcomes:
Locations:
city: Winnipeg
country: Canada
facility: University of Manitoba Health Sciences Centre
state: Manitoba
city: Hamilton
country: Canada
facility: St. Joseph Healthcare, St. Joseph Hospital
state: Ontario
Study officials:
affiliation: McMaster University
name: PJ Devereaux, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00845325: Early Motion Following Carpal Tunnel Release
Official title: Early Motion Following Carpal Tunnel Release, a Randomized Control Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Carpal Tunnel Syndrome
Keywords: Carpal tunnel release
Rehabilitation
Early motion
Lead sponsor: University of Missouri-Columbia
Sponsor class: OTHER
First posted: 2009-02-18
Enrollment: 16
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: To objectively and subjectively assess two modes of commonly employed rehabilitation and confirm a superior method to treat patients following carpal tunnel release.

One of the problems following carpal tunnel release (CTR) for carpal tunnel syndrome, and all hand surgeries, is the debilitation in the postoperative period. This relates to muscle atrophy and joint stiffness due to immobilization or relative inactivity in the postoperative period. Specifically, patients suffer increased days off from work, lost wages, and difficulties with activities of daily living affecting the patient and society at large. CTR is a very common procedure in hand surgery making it easy to study and important to optimize the postoperative care.

Detailed description: The surgical procedure, carpal tunnel release, will be performed in a standard open fashion. In a random fashion, the patients will be placed into either of two rehabilitation groups following CTR with specifically different postoperative instructions after the procedure.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of carpal tunnel syndrome
* Recommended for carpal tunnel release

Exclusion Criteria:

* Severe thenar weakness
* proximal neuropathy of the same arm.
* generalized peripheral neuropathy
* active psychiatric disorder
* chronic renal failure require dialysis
* reflex sympathetic dystrophy
* previous injury of affected wrist or median nerve
* simultaneous ipsilateral upper extremity surgery
* carpal tunnel syndrome with acute injury

Primary outcomes:
measure: days to return to activities of daily living, return to work, grip strength, pinch strength, digital sensibility, subjective pain control, number of pain pills used, grading of success,and any complications encountered.
timeFrame: 1 week, 3 weeks, 3 months, and 1 year postoperatively
Secondary outcomes:
Other outcomes:
Locations:
city: Columbia
country: United States
facility: University of Missouri
state: Missouri
Study officials:
affiliation: University of Missouri-Columbia
name: Stephen H Colbert, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04737525: Connective Tissue Graft Versus a Porcine-derived Membrane (Mucoderm) After Immediate Placement
Official title: The Influence of a Connective Tissue Graft Versus a Porcine-derived Membrane (Mucoderm) on the Aesthetic Outcome After Immediate Placement and Loading of a Tapered Dental Implant in the Anterior Maxilla. A Randomized Controlled Clinical Trial.
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Immediate Implants
Keywords: Soft tissue grafting
Lead sponsor: Vilniaus Implantologijos Centro (VIC) Klinika
Sponsor class: NETWORK
Collaborators: name: Straumann Group
First posted: 2021-02-04
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Esthetic outcome of immediate implant placement in fresh extraction sockets remains one of the biggest challenges in implant dentistry. Recently a method to preserve the peri-implant tissues was introduced using provisional restoration, allogenic bone and soft tissue thickening. However, the evidence that this immediate provisialisation with soft tissue grafting using different grafting materials results in constantly high Pink Esthetic scores, especially compared to the delayed loading approach is still lacking.

The aim of this clinical trial is to assess the esthetic outcome of immediate temporization of immediately placed and loaded tapered implants in fresh extraction sockets with bone and soft tissue augmentation, using either a connective tissue graft (CTG) or a porcine-derived membrane (Mucoderm) in maxillary anterior sites.

The secondary objectives are to investigate the influence of immediate loading on the success rate of tapered implants and crestal bone levels.


Eligibility criteria: Inclusion Criteria:

1. Males and females of at least 18 years of age
2. 1 implant per patient
3. Subject must have voluntarily signed the informed consent before any study related action, are willing and able to attend scheduled follow-up visits, and agree that the pseudonymized data will be collected and analyzed
4. Anterior single teeth (canines and incisors) in both jaws
5. Class I extraction socket (intact buccal wall) or Class II (1/3 of buccal wall)
6. No recession of gingival contour of tooth to be extracted
7. No periodontal bone loss of neighboring anterior teeth
8. No implants in neighboring teeth
9. Atraumatic extraction of the tooth with intact socket walls remaining

Exclusion Criteria:

1. Deep bite (severe II class)
2. Heavy smokers (more than 10 cigarettes/day)
3. Systemic disease (diabetes, osteoporosis)
4. Primary stability after implant placement not achieved
5. Pregnancy

Primary outcomes:
measure: Aesthetic evaluation
timeFrame: Change from baseline, 1 year, 5 and 10 years after prosthetic delivery
Secondary outcomes:
measure: Recession of gingiva (REC)
timeFrame: Change from baseline, 1 year, 5 and 10 years after prosthetic delivery
Other outcomes:
Locations:
city: Vilnius
country: Lithuania
facility: VIC clinic
Study officials:
References:
Clinical trial NCT06778525: The Effect of Rehabilitative Games With SmartPose on Upper Extremity Recovery in Stroke Patients
Official title: The Effect of Rehabilitative Games With SmartPose Practice on Upper Extremity Recovery in Ischemic Stroke Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke, Ischemic
Smartpose
Telerehabilitation
Keywords: Rehabilitation
Stroke
Exergaming
Upper Extremity
Lead sponsor: Istanbul University - Cerrahpasa
Sponsor class: OTHER
First posted: 2025-01-16
Enrollment: 34
Sex: ALL
Minimum age (years): 35
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to investigate the effects of SmartPose games on upper extremity motor, functional, and sensory recovery in patients with stroke. The main question it aims to answer is:

* Does the use of rehabilitative games with the SmartPose application work to treat upper extremity motor, functional, and sensory recovery in stroke patients?

Researchers will compare the experimental group with the control group, which receives only conventional exercises with proven effectiveness, to determine whether SmartPose has an effect on upper extremity motor, functional, and sensory recovery in stroke patients.

The experimental group will receive 30 minutes of neuromuscular therapy and 30 minutes of SmartPose, 3 times a week for 8 weeks.

The control group will receive 60 minutes of neuromuscular therapy, 3 times a week for 8 weeks.


Eligibility criteria: Inclusion Criteria:

* Mini Mental State Examination score ≥ 24
* Age between 35 and 75 years
* Medical condition sufficiently stable to allow participation in active rehabilitation
* Brunnstrom Upper Extremity Stage ≥ 3
* Minimum sixth week post-stroke
* Ability to perform shoulder abduction and flexion against gravity with a minimum of 20°

Exclusion Criteria:

* Presence of secondary impairments affecting upper extremity movement
* Modified Ashworth Scale score of 4 or 5
* Inability to maintain independent sitting balance
* Visual impairment or loss that prevents the perception of visual materials

Primary outcomes:
measure: The Fugl-Meyer Assessment of Motor Recovery after Stroke - Upper Limb
timeFrame: Baseline and 8 weeks
measure: Frenchay Arm Test
timeFrame: Baseline and 8 weeks
Secondary outcomes:
measure: Modified Ashworth Scale
timeFrame: Baseline and 8 weeks
measure: Brunnstrom Stages of Stroke Recovery
timeFrame: Baseline and 8 weeks
measure: Box and Block Test
timeFrame: Baseline and 8 weeks
measure: Functional Independence Measure
timeFrame: Baseline and 8 weeks
measure: Stroke Specific Quality of Life Scale
timeFrame: Baseline and 8 weeks
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul University-Cerrahpasa, Faculty of Health Science
Study officials:
References:
Clinical trial NCT03134625: Metabolite Biomarkers Related to Acute Rejection in Kidney Transplantation
Official title: Identification of Metabolite Biomarkers Related to Acute Rejection of Patients With Kidney Transplantation
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Kidney Transplantation
Rejection Acute Renal
Keywords: metabolomics
biomarker
acute rejection
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2017-05-01
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study population includes low or moderate risk kidney transplantation. They should have triple immunosuppression.

Brief summary: The development of acute rejection can only be considered in cases with increasing serum creatinine in patients with kidney transplantation. However, the serum creatinine itself is not specific but also accurate for detection of acute rejection. So The specific biomarker is required for acute rejection of kidney transplant. In this study, the investigators will enroll 200 consecutive kidney transplant patients in Seoul National University Hospital and follow up. Serial collection of urine and serum will be done. Acute rejection specific urine metabolite will be found by LC MS/MS.


Eligibility criteria: Inclusion Criteria:

* Kidney transplant patients in Seoul National University Hospital
* Patients with triple maintenance immunosuppression including Tacrolimus, mycophenolate and steroid

Exclusion Criteria:

* History of other organ transplantation
* ABOi and/or crossmatch(+) transplantation

Primary outcomes:
measure: biomarker for acute rejection in kidney transplantation
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References:
Clinical trial NCT05183425: Patient-derived Organoids Predicts the Clinical Efficiency of Colorectal Liver Metastasis
Official title: The Exploratory Study of Patient-derived Organoids for the Prediction and Evaluation of Clinical Efficiency Effect of Colorectal Cancer Liver Metastasis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Explore the Consistency of Drug Sensitivity Between Primary Colorectal Cancer and Liver Metastases
Lead sponsor: Changhai Hospital
Sponsor class: OTHER
First posted: 2022-01-10
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients with histologically proven colorectal cancer with liver metastasis.

Brief summary: Accumulating evidence indicates that patient- derived organoids (PDOs) can predict drug responses in the clinic. Metastasis is the main cause of death in colorectal cancer patients, and the treatment of patients with liver metastasis remains poor. Tumor heterogeneity is the cause of treatment failure. In this study, we aim the investigate the consistency of drug sensitivity for the matched primary and metastatic tumor in patients with liver metastasis.


Eligibility criteria: Inclusion Criteria:

* Histologically proven colorectal cancer with liver metastasis
* Aged between 18 and 70 years
* Written informed and signed consent
* Accessible to surgery sample of metastasis and primary tumor

Exclusion Criteria:

* Less than 18 years and older than 70 years
* Not able to give informed consent
* Not accessible to surgery sample

Primary outcomes:
measure: The consistency of drug sensitivity
timeFrame: 3 years
Secondary outcomes:
measure: The establishment of PDO
timeFrame: 3 years
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Department of Colorectal Surgery in Changhai Hospital
state: Shanghai
Study officials:
References:
Clinical trial NCT04471025: Jedi Grip Versus Double Operator Technique For Ultrasound Guided Infraclavicular Block
Official title: A Prospective, Randomized, Observer-Blinded Comparison Between Single And Double Operator In Ultrasound Guided Infraclavicular Block: Jedi Grip Versus Conventional Double Operator Technique
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ultrasound
Nerve Block
Keywords: Jedi Grip
Ultrasound guided infraclavicular block
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2020-07-14
Enrollment: 78
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: single-center, prospective, randomized into two goups: Jedi grip versus conventional double operator technique
Primary purpose: SUPPORTIVE_CARE

Brief summary: The investigators aimed to compare the block characteristics of the single operator "jedi grip" technique and the conventional double operator technique.

Detailed description: Patients undergoing hand, wrist, elbow and forearm surgery randomly assigned two groups (Group I: Jedi grip and Group II: Conventional double operator technique). By a blind observer, the block characteristics were evaluated and recorded .

Eligibility criteria: Inclusion Criteria:

* undergoing elective hand, wrist and forearm surgery

Exclusion Criteria:

* hepatic or renal failure
* serious cardiac or pulmoner disease
* local or systemic infection
* sepsis
* coagulation disorder
* neurological, muscular or psychiatric disease
* body mass index (BMI) below 18.5 or above 35
* drug and substance abuse
* pregnancy
* refusal of regional anesthesia
* history of allergy to local anesthetics
* mental-motor retardation (inability to consent or assess the visual analog scale(VAS) pain score)
* preoperative long-term NSAIDs or opioid use.

Primary outcomes:
measure: block performance time
timeFrame: during block application
measure: block success
timeFrame: during surgery
Secondary outcomes:
measure: Sensory block onset time
timeFrame: before surgery
measure: motor block onset time
timeFrame: before surgery
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara City Hospital
Study officials:
affiliation: Ankara City Hospital Anesthesiology Department
name: İsmail Aytac
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pappin D, Christie I. The Jedi Grip: a novel technique for administering local anaesthetic in ultrasound-guided regional anaesthesia. Anaesthesia. 2011 Sep;66(9):845. doi: 10.1111/j.1365-2044.2011.06845.x. No abstract available.
Clinical trial NCT01517425: Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells
Official title: Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Coronary Artery Disease
Lead sponsor: Scripps Translational Science Institute
Sponsor class: OTHER
First posted: 2012-01-25
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects previously enrolled in the Scripps Genebank or Healthy Elderly Active Longevity (HEAL) Cohort

Brief summary: This research is being done to understand how changes in DNA may put people at risk for developing coronary artery disease. Stem cells will be made using cells from blood and/or skin biopsy samples. We are trying to understand which specific changes in DNA negatively impact a person's health.


Eligibility criteria: Inclusion Criteria:

Cases:

1. Previously enrolled in the CAD module of the Genebank at Scripps Clinic Registry
2. Eligible to have their blood drawn
3. Be reliable, cooperative and willing to comply with all protocol-specified procedures
4. Able to understand and grant informed consent

Controls:

1. Previously enrolled in the Healthy Elderly Active Longevity (HEAL) Cohort
2. Eligible to have their blood drawn
3. Be reliable, cooperative and willing to comply with all protocol-specified procedures
4. Able to understand and grant informed consent

Exclusion Criteria:

1. Unwilling or unable to grant informed consent.
2. Have a significant medical condition that in the Investigator's opinion may interfere with subject's study participation.

Primary outcomes:
measure: iPSC development
timeFrame: five years
Secondary outcomes:
Other outcomes:
Locations:
city: La Jolla
country: United States
facility: Scripps Translational Science Institute
state: California
Study officials:
References:
Clinical trial NCT04266925: Preventing Youth Soccer Injury
Official title: Preventing Youth Soccer Injury
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Injuries
Sports Injury
Sports Injuries in Children
Keywords: youth soccer injury
Lead sponsor: University of Alabama at Birmingham
Sponsor class: OTHER
First posted: 2020-02-12
Enrollment: 49
Sex: ALL
Minimum age (years): 8
Maximum age (years): 11
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: A study is proposed to test whether adding additional referees to youth soccer matches may reduce the risk of injury to the children playing soccer. Publicly-open youth soccer games will be randomly assigned to have either one or three referees and videotaped. The videotaped games will then be watched to record risk-taking behavior by players, referee decisions, and other factors relevant to potential injury.


Eligibility criteria: Inclusion Criteria:

* unit of measurement was youth soccer teams playing in Birmingham, Alabama area league

Exclusion Criteria:

* teams serving children under age 9 or over age 11

Primary outcomes:
measure: Average Number of Injuries During Soccer Matches
timeFrame: baseline through one hour, which is beginning of the game until the end of the game, averaged across games
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: UAB Youth Safety Lab, University of Alabama at Birmingham
state: Alabama
Study officials:
affiliation: University of Alabama at Birmingham
name: David Schwebel, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Schwebel DC, Long DL, McClure LA. Injuries on the Youth Soccer (Football) Field: Do Additional Referees Reduce Risk? Randomized Crossover Trial. J Pediatr Psychol. 2020 Aug 1;45(7):759-766. doi: 10.1093/jpepsy/jsaa050.
Clinical trial NCT03327025: Survivor Health and Resilience Education
Official title: Survivor Health and Resilience Education
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pediatric Cancer
Lead sponsor: Georgetown University
Sponsor class: OTHER
First posted: 2017-10-31
Enrollment: 17
Sex: ALL
Minimum age (years): 8
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: An intervention to assist pediatric cancer survivors to behaviorally manage late effects.


Eligibility criteria: Inclusion Criteria:

* Pediatric cancer survivor

Exclusion Criteria:

-

Primary outcomes:
measure: Tobacco use
timeFrame: 1 Month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: