louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02710058: Experience of Arab American Women With Breast Cancer: In-depth Interviews
Official title: Experience of Arab American Women With Breast Cancer: In-depth Interviews A Qualitative Study to Explore the Influence of the Arab Culture on Coping With Breast Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Breast Cancer
Keywords: support group
15-246
The Arab American Breast Cancer Education and Referral Program (AMBER)
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2016-03-16
Enrollment: 8
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study is open to current and previous AMBER support group participants held at the MSK Brooklyn Infusion Center.

Brief summary: The investigators are conducting a study entitled 'Experience of Arab American Women with Breast Cancer: In-depth Interviews' through which they hope to learn more about Arab women's experience with breast cancer.


Eligibility criteria: Inclusion Criteria:

* AMBER participant diagnosed with breast cancer who attended at least 1 support group meeting
* Aged 18 to 85
* Arabic-speaking

Exclusion Criteria:

None

Primary outcomes:
measure: Understanding the influence of Arab culture on health behavior
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Brooklyn
country: United States
facility: MSKCC Brooklyn Infusion Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Francesca Gany, MD, MS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04403958: The Use of Proximal Carpal Row Versus Iliac Crest as Bone Graft in Total Wrist Fusion
Official title: The Use of Proximal Carpal Row Versus Iliac Crest Bone Graft in Total Wrist Fusion - a Randomized Controlled Multicenter Trial Comparing Two Operative Techniques (PROOF II - Trial)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Wrist Arthritis
Fusion; Joint
Lead sponsor: Töölö Hospital
Sponsor class: OTHER
Collaborators: name: Turku University Hospital
name: Kymenlaakso Central Hospital Kotka Finland
First posted: 2020-05-27
Enrollment: 84
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Study purpose is to compare the outcome after total wrist arthrodesis (TWA) with proximal carpal row (Proximal Row Carpectomy = PRC) as bone graft versus iliac crest cancellous bone graft.

Patients with radiologically and clinically confirmed advanced osteoarthritis are randomized (1:1 computer generated sequence with random block size) to two parallel groups and will undergo either total wrist arthrodesis with PRC or TWA with iliac crest bone grafting.

Baseline data is collected preoperatively and is a follow-up visits at every 6 weeks after the surgery is arranged until the wrist is fused. The primary end-point is 6 months and the primary outcome is fusion rate.


Eligibility criteria: Inclusion Criteria:

* Age 18 - 75
* Symptom duration \> 3 months
* American Society of Anaesthesiologists physical status (ASA) I-III
* Fluent in written and spoken Finnish

Exclusion Criteria:

* Age \<18 or \>75 years
* Rheumatoid arthritis
* Heavy smoking (\> 20 cigarettes per day)
* Condition or medication affecting bony healing (eg diabetes mellitus with poor glycemic control, malnutrition, use of per oral corticosteroids)
* Ulnar variance \> 1 mm
* Wrist pain treatable with partial wrist fusion
* Previous partial wrist fusion
* Alcohol or drug abuse
* Neurological condition affecting upper limb function
* Less than 6 months after another operation of the same upper limb

Primary outcomes:
measure: Fusion rate (percent)
timeFrame: 6 months
Secondary outcomes:
measure: Pain (Visual Analogue Scale)
timeFrame: 6 months
measure: Patient-Rated Wrist Evaluation (PRWE)
timeFrame: 6 months
measure: Quick-Disabilities of the Arm, Shoulder and Hand (QuickDASH)
timeFrame: 6 months
measure: Global improvement
timeFrame: 6 months
measure: Grip strength
timeFrame: 6 months
measure: Operative time
timeFrame: Perioperative
measure: Complications
timeFrame: 12 months
Other outcomes:
Locations:
Study officials:
affiliation: HUS Töölö Hospital
name: Samuli Aspinen, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06208358: A Study for the Disrupted Interpersonal Interaction Among Gaming Disorder Individuals and Treatment
Official title: Brain Mechanism of Disrupted Interpersonal Interaction in Gaming Disorder Affecting Cognitive Control and Its Hierarchical Multidimensional Evaluation Intervention
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Gaming Disorder
Lead sponsor: Shanghai Mental Health Center
Sponsor class: OTHER
First posted: 2024-01-17
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aiming at the major problems of unclear brain mechanism of gaming disorder and lack of effective assessment intervention tools, this project started by exploring the brain mechanism of abnormal interpersonal interaction and cognitive control deficit promoting and accelerating the development of gaming disorder, adopted a prospective cohort study design, combined with multi-modal brain functional imaging, cognitive function, social psychological assessment, and other means. To clarify the brain mechanism and outcome of gaming disorder. Based on the preliminary stage, for high-risk groups, risky gaming behavior, gaming disorder layout hierarchical multidimensional assessment intervention system, using science education, brief intervention, social psychological intervention, neural regulation, cognitive rehabilitation training, mobile medical treatment, and other ways, stratification and stage, early identification, prevention and treatment combination, accurate intervention to comprehensively reduce the occurrence and development of gaming disorder.


Eligibility criteria: Inclusion Criteria:

* (1)Clinical diagnosis of severe Gaming Disorder defined in the ICD-11; (2)Normal hearing and vision, or within normal range after correction;

Exclusion Criteria:

* (1) Clinical diagnosis of mental health disorders other than GD defined in the ICD-11 in the past 5 years；(2) Suffering from diseases that affect cognitive function (such as cerebrovascular diseases) ; (3) Schizophrenia, bipolar disorder, depression or other Axis I disorder of DSM-V criteria;(4)any contraindication for tACS intervention.

Primary outcomes:
measure: cue-induced craving
timeFrame: Two weeks,Four weeks
measure: inter-brain synchronization (IBS)
timeFrame: Two weeks,Four weeks
measure: cognition measures
timeFrame: Four weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Mental Health Center
state: Shanghai
Study officials:
References:
Clinical trial NCT05584358: Protein Extrusion and Postprandial Amino Acid Handling
Official title: The Impact of the Extrusion Process During Dietary Protein Production on in Vivo Postprandial Amino Acid Availability
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postprandial Plasma Amino Acid Availability
Lead sponsor: University of Exeter
Sponsor class: OTHER
Collaborators: name: Quorn
First posted: 2022-10-18
Enrollment: 9
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The bulk of research that has investigated the effect of dietary protein on muscle tissue in humans has used isolated, minimally processed protein powders. However, the protein that we consume on a daily basis has typically undergone various processing methods, and evidence suggests these can change the way our bodies metabolise the protein. 'Extrusion' is a common processing method that uses high pressure to produce protein containing cereals and meat replacement foods. There is currently no research looking at how extrusion affects the way a protein source is digested and absorbed in humans. This study will compare the availability of ingested protein in the blood in the hours following consumption of an extruded versus a non-extruded source.


Eligibility criteria: Inclusion Criteria:

* BMI between 18 and 30.
* Metabolically healthy

Exclusion Criteria:

* Any metabolic impairments
* cardio/pulmonary diseases.
* Chronic use of the over the counter medicine
* A personal or family history of epilepsy, seizures or schizophrenia.
* Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.

Primary outcomes:
measure: Plasma amino acid concentrations
timeFrame: 5 hours
Secondary outcomes:
measure: Blood glucose
timeFrame: 5 hours
measure: Serum insulin
timeFrame: 5 hours
measure: Resting metabolic rate
timeFrame: 5 hours
Other outcomes:
Locations:
city: Exeter
country: United Kingdom
facility: Sport & Health Sciences University of Exeter
state: Devon
city: Exeter
country: United Kingdom
facility: University of Exeter
state: Devon
Study officials:
affiliation: Professor of Nutritional Physiology
name: Benjamin Wall
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00177658: NCCLS Interpretive Criteria for Salmonella
Official title: NCCLS Interpretive Criteria for Salmonella
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Salmonella Infection
Keywords: Salmonella
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
Collaborators: name: Centers for Disease Control and Prevention
First posted: 2005-09-15
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: isolates with salmonella

Brief summary: To determine the clinical significance of gene mutations encoding antibiotic resistance, but not expressed as clinical resistance, in Salmonella bacteria

Detailed description: Observational study. Physicians in foreign countries caring for patients with Salmonella meningitis or bloodstream infections will collect data on the patients they care for and send this data and an isolate of the organism causing the infection to the University of Pittsburgh.

Eligibility criteria: Inclusion Criteria:

* salmonella positive isolate

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: University of Pittsburgh Medical Center
state: Pennsylvania
Study officials:
affiliation: University of Pittsburgh
name: David Paterson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00515658: Antidepressant Effect of Theta-Burst rTMS
Official title: Antidepressant Effect of Theta-Burst rTMS
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Major Depression
Keywords: Major depression
Theta-burst rTMS
Cortical excitability
Hamilton depression rating scale
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2007-08-14
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to evaluate the safety and efficacy of theta-burst rTMS in patients with major depression. Patients will be randomized to receive ether left-sided intermittent theta-burst rTMS or rigt-sided continuous theta-burst rTMS or sham theta-burst rTMS over two weeks period with an option for an additional two weeks period, depending on treatment response. Clinical assessments will be performed weekly by the Hamilton depression rating scale. In addition, standard neurophysiological assessment of cortical excitability will be done.


Eligibility criteria: Inclusion Criteria:

* Major depressive episode (DSM IV criteria).
* Informed consent.
* Age: 18-70.

Exclusion Criteria:

* Suicidality
* Psychosis
* Pacemaker
* Cardiac arrythmia
* seizure disorder
* implantable metal devices
* PNS and CNS disorders
* any other contraindications as specified in safety guidelines for rTMS (Wassermenn, 1998).

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Rambam Medical Center
Study officials:
affiliation: Rambam Health Care Campus
name: Ehud Klein, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04212858: Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma
Official title: Amplification of Zinc- Finger Protein 217 Gene in Multiple Myeloma Patients as a Prognostic Marker
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Multiple Myeloma
Keywords: Zinc finger 217 protein gene .
Multiple myeloma
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2019-12-30
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Multiple myeloma (MM) is blood disorder characterized by the detection of a monoclonal paraprotein in serum or urine, which is often associated with the presence of clonal plasma cells (PCs) mainly in the bone marrow (BM) .The zinc-finger protein 217 (ZNF217) is an oncogenic protein that plays deleterious functions in various human cancers. The ZNF217 gene is located at the 20q13 chromosomal region, which is frequently amplified in human tumors .

Detailed description: Multiple myeloma (MM) is blood disorder characterized by the detection of a monoclonal paraprotein in serum or urine, which is often associated with the presence of clonal plasma cells (PCs) mainly in the bone marrow (BM) . MM is the second most common hematologic malignancy and is expected to cause ∼13 000 new cases and 30 000 deaths in 2018. Myeloma is a genetically complex disorder characterized by multiple genetic changes, affecting different pathways, that have the ability to deregulate plasma cell biology leading to a broadly similar phenotypic manifestation of disease. From a genetic perspective, myeloma can be divided into those with and without a hyperdiploid karyotype .The zinc-finger protein 217 (ZNF217) is an oncogenic protein that plays deleterious functions in various human cancers. The ZNF217 gene is located at the 20q13 chromosomal region, which is frequently amplified in human tumors . This region also contains several oncogenes thought to confer selective advantages to cancer cells. Increased copy numbers of ZNF217 have been reported in various tumors and linked to poor outcome in some studies . ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy. ZNF217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression. In our best knowledge, No studies were done to detect ZNF217 in multiple myeloma.

Eligibility criteria: Inclusion Criteria:

* Newly diagnosed multiple myeloma patients, who fulfill the WHO criteria of myeloma diagnosis.

Exclusion Criteria:

* Patients with any other type of malignant or benign tumors should be excluded from our study.

Primary outcomes:
measure: zinc-finger protein gene 217 in myeloma patients
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02015858: Pain During Chest Tube Withdrawal: Evaluation Using Pan Monitor
Official title: Pain During Chest Tube Withdrawal: Evaluation Using Pan Monitor in Patients With or Without Epidural Anesthesia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chest Pain
Lead sponsor: Hopital Foch
Sponsor class: OTHER
First posted: 2013-12-19
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Lung surgical patients

Brief summary: Pain evaluation remains a clinical problem. Pain Monitor allows pain evaluation using the measurement of skin conductance.

Withdrawal of chest tube can be painful and the purpose of the study was to compare auto-evaluation of pain (visual analogic scale) and the index measured by the Pain Monitor.


Eligibility criteria: Inclusion Criteria:

* patients undergoing removal of a chest tube after lung surgery,
* patients able to indicate the pain score.

Exclusion Criteria:

* pregnancy, lactation ,
* insulin-dependent diabetes with dysautonomia,
* central or peripheral neurological disease, agitation,
* inability to understand the protocol,
* inability to use the Pain Monitor: skin abnormalities at the site of measurement, pacemaker or implantable defibrillator, condition affecting the sympathetic nervous system, tremor of the extremities,
* contra-indication to oral morphine ,
* respiratory failure, severe hepatic insufficiency, intracranial hypertension, epilepsy associations
* recent administration of neostigmine or of atropine.

Primary outcomes:
measure: Pain monitor evaluation of pain
timeFrame: 1 hour
Secondary outcomes:
measure: Pain intensity
timeFrame: 1 hour
Other outcomes:
Locations:
city: Suresnes
country: France
facility: Hopital Foch
Study officials:
affiliation: Hôpital Foch
name: Marc Fischler
role: STUDY_CHAIR
References:
Clinical trial NCT03779958: Alternatives to Hand Therapy for Hand Surgery Patients
Official title: Alternatives to Hand Therapy for Hand Surgery Patients
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Carpal Tunnel Syndrome
Trigger Finger
Ganglion Cysts
Distal Radius Fracture
Finger Fracture
De Quervain Syndrome
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2018-12-19
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients presenting to a single hand surgery clinic

Brief summary: Patients will be asked to use a mobile phone app to conduct their hand therapy after having hand surgery.

Detailed description: Patients who are undergoing the included procedures will be informed of the study \& consented. They will be given information on how to download the app \& input their surgery date. The app will guide the patient through various hand therapy exercises and ask them to record their QuickDASH, PSFS and VAS Pain weekly.

Eligibility criteria: Inclusion Criteria:

* patients undergoing the following procedures: carpal tunnel release, trigger finger release, distal radius fracture fixation, de quervains release, cyst excision, finger fracture fixation
* smart phone that is compatible with the app

Exclusion Criteria:

-

Primary outcomes:
measure: QuickDASH
timeFrame: once a week for 6 weeks
Secondary outcomes:
measure: Patient Specific Functional Scale
timeFrame: once a week for 6 weeks
measure: VAS Pain
timeFrame: once a week for 6 weeks
Other outcomes:
Locations:
city: Redwood City
country: United States
facility: Stanford Health Care
state: California
Study officials:
affiliation: Stanford University
name: Robin N Kamal, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03183258: Vascularised Sentinel Skin Flaps to Detect Rejection in Pancreas Transplantation
Official title: Vascularised Sentinel Skin Flaps to Detect Rejection in Pancreas Transplantation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Pancreas Transplant Rejection
Lead sponsor: University of Oxford
Sponsor class: OTHER
First posted: 2017-06-12
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This pilot study aims to validate the use of vascularised donor-derived sentinel skin flaps for diagnosing rejection in pancreas transplantation. The aim of the study is to investigate the use of sentinel skin flaps in clinical practice and assess whether rejection occurs concordantly or discordantly between the skin flap and the transplanted abdominal organs. If successful, sentinel skin may allow improved immune surveillance and thereby facilitate earlier treatment of rejection with subsequent improvements in allograft survival and patient morbidity.


Eligibility criteria: Inclusion Criteria:

* Recipient of a pancreas transplant (SPK or PTA)
* Participant is willing and able to give informed consent for participation in the study
* Male or Female, aged 18 years or above

Exclusion Criteria:

* Patient does not have a patent ulna artery in either forearm
* Recipient of an enterically drained PTA
* Patient has received any investigational medical drug within 30 days of transplantation
* Patient is not willing to return to Oxford for all clinical follow-up for 12 months
* Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the trial, or the participant's ability to participate in the study.

Primary outcomes:
measure: Concordant allograft rejection
timeFrame: 12 months
Secondary outcomes:
measure: Discordant rejection of the sentinel skin
timeFrame: 12 months
measure: Discordant rejection of the visceral allograft
timeFrame: 12 months
measure: Donor specific antibodies
timeFrame: 12 months
measure: Immunosuppression
timeFrame: 12 months
measure: Graft survival
timeFrame: 12 months
Other outcomes:
Locations:
city: Oxford
country: United Kingdom
facility: Oxford University Hospitals NHS Foundation Trust
Study officials:
affiliation: University of Oxford
name: Peter J Friend
role: PRINCIPAL_INVESTIGATOR
References: