Clinical trial NCT04820946: Evolution of DMDD Children and Adolescent
Official title: Evolution of Children and Adolescents With Disruptive Mood Dysregulation Disorder Refereed to Hospital for Suicidal Behavior After Three Year: Diagnostic Stability, Psychiatric Comorbidity, Psychosocial Functioning, Identification of Clinical and Actigraphy-measured Prognosis Factors
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Disruptive Mood Dysregulation Disorder
Prognosis Factors
Suicidal Behaviors
Actigraphy
Keywords: Disruptive Mood Dysregulation Disorder
prognosis factors
natural course
suicidal behaviors
actigraphy
pediatric depressive disorder
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2021-03-29
Enrollment: 55
Sex: ALL
Minimum age (years): 10
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: DMDD patients referred to the hospital for suicidal behaviors between 2013 and 2018 in terms of diagnostic stability, psychiatric comorbidity, and psychosocial factors.

A group of patients with various episodic mood disturbances was used as a clinical case control group.

Brief summary: Little is known about the natural course and prognosis factors of inpatients and outpatients with Disruptive Mood Dysregulation Disorder (DMDD). The investigators conducted a cross-sectional study to determine the evolution of a sample of DMDD patients referred to the hospital for suicidal behaviors between 2013 and 2018 in terms of diagnostic stability, psychiatric comorbidity, and psychosocial factors. A group of patients with various episodic mood disturbances was used as a clinical case control group.

In addition to change in DMDD symptoms across time, the investigators examined the onset and persistence of psychiatric comorbidity using the KIDDIE-SADS PL and suicidal behaviors using the Colombia Suicidality Severity Rating Scale. The investigators also examined the persistence of depressive symptoms using the Beck Depression Inventory (BDI-II), the persistence of emotional lability (Affective Lability Scale-18), borderline traits (Abbreviated Diagnostic of Inventory Borderline). Socio-demographic, clinical features and actigraphy-measured sleep characteristics determined between 2013 and 2018 were used to predict the evolution of the DMDD patients and the clinical control group.


Eligibility criteria: Inclusion Criteria:

* Boys and girls between 10 and 25-year-old
* patients who had been referred to the university hospital of Amiens for suicidal behaviors between 2013 and 2018
* patients who participated to the study "Clinical and actigraphy-measured profiles of inpatient youths with suicidal behavior: exploration of the severe mood dysregulation"

Exclusion Criteria:

* No affiliation to a social security service
* Persons deprived of their liberty as stipulated in article L.1121-6 of the Public Health Code

Primary outcomes:
measure: Diagnostic evolution toward an other psychiatric disorder.
timeFrame: one day
measure: persistence of a full-blown DMDD diagnostic
timeFrame: one day
Secondary outcomes:
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens
Study officials:
References: