Clinical trial NCT02689180: Effect of Furosemide Withdraw in Stable Chronic Heart Failure Outpatients
Official title: Effect of Furosemide Withdraw in Stable Chronic Heart Failure Outpatients With Left Ventricular Dysfunction - the Brazilian Research Network on Heart Failure
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Heart Failure
Keywords: heart failure
diuretics
furosemide
Lead sponsor: Hospital de Clinicas de Porto Alegre
Sponsor class: OTHER
Collaborators: name: Conselho Nacional de Desenvolvimento Científico e Tecnológico
First posted: 2016-02-23
Enrollment: 230
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The ReBIC-1 trial was designed to evaluate the potential clinical risks and benefits of withdrawing furosemide use in stable, apparently euvolemic, chronic HF outpatients in a multicentric double-blinded randomized clinical trial.

Detailed description: Diuretics play a central role in HF treatment, particularly during episodes of acute decompensation. Furosemide is the prototype of loop diuretics, acting through the inhibition of the Na+K+2Cl- pump at the thick ascending limb of the Henle loop. According to international registries, almost all patients receive a loop diuretic during a hospital stay for acute decompensated HF and the majority are discharged taking a "maintenance dose". Despite the undeniable beneficial hemodynamic effects of improvement of peripheral and central congestion, the net clinical effect of the chronic use of diuretics on HF prognosis is controversial.

Observational studies suggest that use of high doses of diuretics might be related to unfavorable clinical consequences. Undesirable side effects of loop diuretics are not trivial and involve activation of the renin-angiotensin-aldosterone system, elevation of norepinephrine levels, increases in heart rate, detrimental effects on renal function and several electrolyte disturbances.

Few prospective clinical studies, however, directly evaluated the clinical risks and benefits of diuretics. Most of these studies were under-powered, performed more than 2 decades ago, before modern HF therapy with current drugs and devices was completely implemented.

Current clinical guidelines are unanimous to recommend use of diuretics in HF patients with clinical signs and symptoms of congestion, but reinforce the lack of solid clinical scientific evidence for its use, and the potential risks that might be involved. The European Society of Cardiology proposes the administration of the lowest dose necessary to achieve euvolemia, avoiding the unnecessary delay in the use of drugs that modify the natural history of the disease.

Based on these uncertainties about diuretic use in HF, the ReBIC-1 trial was designed to evaluate the potential clinical risks and benefits of withdrawing furosemide use in stable, apparently euvolemic, chronic HF outpatients in a multicentric double-blinded randomized clinical trial.

ReBIC is a Brazilian research network created to develop clinical studies in heart failure and composed predominantly by university tertiary care hospitals. ReBIC and the ReBIC-1 trial were sponsored by the Brazilian National Council for Scientific and Technological Development (CNPq, Brazil), a public governmental institution. Data collection, management, and analysis were performed at the network's data coordinating center at Hospital de Clínicas de Porto Alegre. All the authors reviewed and approved the manuscript and assume full responsibility for the accuracy and completeness of the data and for the fidelity of this report of the study protocol.

ReBIC-1 is a randomized, double-blind, parallel group, placebo-controlled, two-arm trial comparing the short-term efficacy and safety of discontinuation of furosemide in apparently euvolemic outpatients with chronic stable HF and reduced left ventricular ejection fraction (HF-REF).

Eligibility criteria: The ReBIC-1 study will enroll HF outpatients that fulfill the following criteria:

1. age equal or greater than 18 year-old;
2. New York Heart Association functional class I or II;
3. Left Ventricular Ejection Fraction ≤ 45% by transthoracic two-dimensional echocardiography performed within 3 months before the screening visit;
4. no previous HF related hospitalization or visit to emergency room within 6 months before the screening visit;
5. treatment with a stable dose of furosemide (40 or 80 mg per day) for at least 6 months before the screening visit;
6. plasma potassium \< 5 mg/dl within 3 months before the screening visit;
7. optimal HF treatment with an angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) and beta-blockers, unless contraindicated or not tolerated.

The ReBIC-1 study will exclude HF outpatients that fulfill the following criteria:

1. a clinical congestion score (CCS) \> 5 points;
2. prior acute coronary syndrome, stroke or myocardial revascularization within 3 months before the screening visit;
3. any severe valve heart disease (aortic, mitral or tricuspid);
4. severe pulmonary disease (asthma, emphysema or fibrosis);
5. severe hepatic failure or cirrhosis;
6. end-stage acute or chronic renal disease (on hemodialysis);
7. malignancy on active treatment;
8. congenital heart disease;
9. participation on any other interventional clinical research;
10. inability to understand and sign informed consent.

Primary outcomes:
measure: Feasibility of furosemide withdraw - proportion of patients maintained without diuretic during follow-up
timeFrame: 90 days
measure: Safety of furosemide withdraw - dyspnea score variation assessed by a visual analog scale
timeFrame: 90 days
Secondary outcomes:
measure: Variation of plasmatic levels of natriuretic peptides
timeFrame: Baseline and 90 days
measure: Variation in meters walked assessed by the 6 minute walking test
timeFrame: Baseline and 90 days
measure: Variation in renal function
timeFrame: Baseline, 15, 45 and 90 days
measure: Variation on the Clinical Congestion Score
timeFrame: Baseline, 15, 45 and 90 days
measure: Clinical composite endpoints
timeFrame: 90 days
Other outcomes:
Locations:
city: Porto Alegre
country: Brazil
facility: Cardiovascular Division, Hospital de Clínicas de Porto Alegre
state: RS
Study officials:
affiliation: Hospital de Clínicas de Porto Alegre
name: Luis Eduardo Rohde, PHD
role: STUDY_CHAIR
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