Clinical trial NCT06773104: Autogenous Tooth Bone Graft Versus Allogeneic Bone Graft Around Dental Implant in Aesthetic Zone
Official title: Autogenous Tooth Bone Graft Versus Allogeneic Bone Graft Around Dental Implant in Aesthetic Zone
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Immediate Dental Implants
Thin Labial Plate of Bone Pre-extraction
Hopeless Tooth in Esthetic Zone
Keywords: autogenous tooth bone graft
allogenic bone graft
grafting the jumbing gap
immediate dental implant
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2025-01-14
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: non restorable anterior teeth with thin labial plate of bone
Primary purpose: TREATMENT

Brief summary: 24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation using bone grafts either autogenous tooth bone graft or allogenic bone graft Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft.

• Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous).

Detailed description: 24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation randomized to two groups Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft.

• Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous).

preparation of autogenous tooth bone graft Any restorations, caries, cementum, periodontal ligament and pulp tissue will be removed .The tooth will be grinded using dental bone mill and bone crusher Tooth particles will be sieved to particles size 300 to 1200 microns. The sorted particles will be immersed in 70 % ethanol and 5% Peracetic acid\* in a sterile container for 10 minutes to remove any soft tissue remnants, bacteria and smear layer (defatting and sterilization).

Tooth particles will be demineralized using 2% HNO3for 20 minutes to expose the dentine organic matrix.

The bacteria-free particulate dentin will be washed with phosphate buffered saline‡ twice for 5 minutes to restore the PH balance to 7.4. In the same setting, surgical procedure after atraumatic extraction immediate implant willbe inserted according to dimensions taken from CBCT and jumbing gap will be filled with bone graft according to randomization

Eligibility criteria: Inclusion Criteria:

Patients with non restorable maxillary anterior teeth need to be extracted.

* Thin labial plate of bone of the tooth to be extracted.
* Patients age above 20years old.
* Good oral hygiene.
* No signs of acute infection or inflammation

Exclusion Criteria:

* Prior radiation therapy.
* Soft and hard tissue pathology at the operation site.
* Any relevant systemic disease or medication that might compromise bone healing.

Primary outcomes:
measure: labial bone thickness
timeFrame: 6 months
measure: marginal bone loss
timeFrame: 6 months
Secondary outcomes:
measure: bone density around dental implant
timeFrame: 6 months
measure: implant secondary stability
timeFrame: 6 months
measure: implant success
timeFrame: 6 months
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Faculty of Dentistry
Study officials:
affiliation: faculty of dentistry tanta university
name: diab abdelgaied diab, master
role: PRINCIPAL_INVESTIGATOR
affiliation: faculty of dentistry tanta university
name: Rafic ramadan bedir, professor
role: PRINCIPAL_INVESTIGATOR
affiliation: faculty of dentistry tanta university
name: Ibrahim mohammed nowair, professor
role: PRINCIPAL_INVESTIGATOR
affiliation: faculty of dentistry tanta university
name: Mona samy sheta, lecturer
role: PRINCIPAL_INVESTIGATOR
References: