Clinical trial NCT03946540: Longitudinal Follow Up of Eating Disorder Treatment
Official title: Follow up of Young People Treated in CAEDS 2009-2014. Longitudinal Follow Up of Eating Disorder Treatment
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Feeding and Eating Disorders of Childhood
Anorexia Nervosa
Bulimia Nervosa
Lead sponsor: South London and Maudsley NHS Foundation Trust
Sponsor class: OTHER
First posted: 2019-05-10
Enrollment: 159
Sex: ALL
Minimum age (years): 16
Maximum age (years): 30
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: People who were assessed and offered treatment at the National and Specialist CAMHS Eating Disorder Service, South London and Maudsley NHS Foundation Trust between 1/8/2009 and 31/1/2014

Brief summary: The research proposed here seeks to delineate the outcomes of people who have received treatment for an eating disorder at a specialist eating disorder service in childhood or adolescence (hereafter 'former patients'). This will inform our understanding of the maintenance of treatment effects beyond initial trial follow-ups, and together with data collected during treatment will allow for identification of factors predicting chronicity which will inform further treatment development.

Detailed description: Research Questions

1. Is recovery from an eating disorder in adolescence maintained and associated with good socio-economic outcomes?
2. Is poor outcome from eating disorder treatment in adolescence associated with a chronic course of illness?
3. Are there factors measured during treatment that predict maintenance of outcome or relapse?

This study will use a longitudinal follow up design, contacting former patients of the National and Specialist Child and Adolescent Mental Health Service (CAMHS) Eating Disorder Service, South London and Maudsley National Health Service (NHS) Foundation Trust (CAEDS) between 1/8/2009 and 31/1/2014. These former patients are now aged 16-27. The study will thus provide the longest and largest follow up of treated adolescents to date (n = 358 over a 4-8 year follow up). Former patients will be asked a series of questions by phone/post/email about their health and socio-economic well-being since discharge from the service. This data will be analysed together with assessment and outcome data collected while they were patients of CAEDS.

Measures Data will be collected using a data collection tool developed for this project, as well as the Eating Disorders Examination Questionnaire and the Work and Social Adjustment Scale.

Data collected will comprise:

* Age now
* Employment/education
* Any help sought for eating disorder
* Any help sought for other mental health difficulties
* Current weight
* Current binge/purge symptoms
* Current general well being All data will be self-reported by participants.

Statistical power The primary analysis will be descriptive. We will recruit as many of our original treatment group as possible.

A secondary analysis will be to predict who continues to require mental health care following discharge from CAEDS. Power has been calculated following Babyak's (2004) advice for power calculation for logistic regression of 13 events (continuing mental health care needs) per variable. We have taken figures from the original audit in which 24.1% (n = 69.89) had a poor outcome to hypothesise that a similar proportion of the sample at follow up will have a poor outcome. This is a conservative estimate given the chronicity of eating disorders in adulthood and the longitudinal data of on-going mental health difficulties even in the absence of diagnosable eating disorders. In order to run a logistic regression with 5 predictor variables will require 65 cases with on-going eating disorder symptoms. This will require recruitment of the majority of the original sample assuming the % of on-going difficulties remains the same. Depending on recruitment rate we will adjust analysis accordingly, and reduce the number of predictors in the model.

Data analysis

Planned analyses:

1. Descriptive analysis of key health and socio-economic outcomes for all young people who received treatment in the audited timeframe and split by treatment outcome and diagnosis for between group analysis.
2. Regression analysis to identify predictors of long term outcome from clinical variables measured at baseline assessment and service discharge (including weight, mood, anxiety, eating disorder symptoms)

Eligibility criteria: Inclusion criteria:

* People who were assessed and offered treatment at the National and Specialist CAMHS Eating Disorder Service, South London and Maudsley NHS Foundation Trust between 1/8/2009 and 31/1/2014.

Exclusion criteria:

* young people who were referred for treatment but did not attend assessment
* young people who were referred for treatment but did not meet criteria for an eating disorder
* young people who were referred for treatment but did not accept treatment (or attended for fewer than 3 sessions).

Primary outcomes:
measure: Receipt of further treatment for an eating disorder in the first four years after discharge from treatment
timeFrame: From discharge from service to L-FED research assessment. Discharges between 2009 and 2014 (4-10) year follow up. Proportion of sample needing treatment in the first four years post discharge will be reported
measure: Eating Disorder Examination Questionnaire (EDEQ). Fairburn & Beglin, 1994
timeFrame: 28 days prior to L-FED research assessment
measure: Work and social adjustment scale (WSAS) Mundt, J. C., I. M. Marks, et al. (2002).
timeFrame: At time of L-FED research assessment. Discharges between 2009 and 2014 (4-10) year follow up. Variation in time since discharge will be stratified in analysis.
Secondary outcomes:
measure: Receipt of treatment for an eating disorder >4 years after discharge from treatment
timeFrame: From four years post discharge from service to L-FED research assessment. Proportion
measure: Psychosocial wellbeing
timeFrame: At time of L-FED assessment.Discharges between 2009 and 2014 (4-10) year follow up. Variation in time since discharge will be stratified in analysis.
Other outcomes:
measure: Receipt of treatment for any other mental health difficulties in four years post discharge, and at >4 years post discharge.
timeFrame: 1: Up to four years post discharge. 2: as applicable up to 10 years post discharge as described able for receipt of treatment for an eating disorder
measure: Self harm since discharge
timeFrame: Four time points assesed: while in treatment, since discharge, in the past three months on in the past month. Variation in time since discharge will be stratified in analysis.
measure: Current eating disorder symptoms
timeFrame: At time of L-FED assessment. Discharges between 2009 and 2014 (4-10) year follow up. Variation in time since discharge will be stratified in analysis.
Locations:
city: London
country: United Kingdom
facility: Maudsley Centre for Child and Adolescent Eating Disorders
Study officials:
affiliation: South London and Maudsley NHS Foundation Trust
name: Catherine s Stewart, }hD DClinPsy
role: PRINCIPAL_INVESTIGATOR
References: