louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04367363: Social Media and COVID-19
Official title: Tracking WhatsApp Behaviors During a Crisis: A Longitudinal Observation of Messaging Activities During the COVID-19 Pandemic
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronavirus
Depression
Anxiety
Stress
Keywords: Social Media
Misinformation
COVID-19
Lead sponsor: Yale-NUS College
Sponsor class: OTHER
First posted: 2020-04-29
Enrollment: 151
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Representative sample of the Singapore population

Brief summary: In this protocol, we seek to examine the role of popular messaging platform WhatsApp in information spread during a crisis. As there have been few global crises in the last decade (coinciding with the rise of social media), the role of private messaging platforms such as WhatsApp during crisis contexts remains understudied. During the current COVID-19 global health crisis, we undertook this study to: (1) characterize the nature of WhatsApp use during crises, (2) characterize the profiles of WhatsApp users (3) understand how WhatsApp usage links to well-being (fear and thoughts about COVID-19).


Eligibility criteria: Inclusion Criteria:

* At least 21 years
* Has stayed in Singapore for at least 2 years
* Has a WhatsApp account that can be used for the research study

Exclusion Criteria:

* Below 21 years
* Has stayed in Singapore for less than 2 years
* Does not have a WhatsApp account that can be used for the research study

Primary outcomes:
measure: WhatsApp usage
timeFrame: 1 week, starting from date after baseline survey completion
measure: Changes in fear with regards the COVID-19 situation across 1 week
timeFrame: 1 week, starting from date after baseline survey completion
measure: Changes in amount of thinking about the COVID-19 situation across 1 week
timeFrame: 1 week, starting from date after initial survey completion
Secondary outcomes:
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: Yale-NUS College
Study officials:
affiliation: Yale-NUS College
name: Jean Liu, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tan EY, Wee RR, Saw YE, Heng KJ, Chin JW, Tong EM, Liu JC. Tracking Private WhatsApp Discourse About COVID-19 in Singapore: Longitudinal Infodemiology Study. J Med Internet Res. 2021 Dec 23;23(12):e34218. doi: 10.2196/34218.
Clinical trial NCT05991063: The Ability Of Inferior Vena Caval Distensibility Index With Passive Leg Raising Test To Predict Spinal Anesthesia-induced Hypotension In Elderly Patients Undergoing Infra-umbilical Surgeries. A Prospective Observational Study.
Official title: The Ability Of Inferior Vena Caval Distensibility Index With Passive Leg Raising Test To Predict Spinal Anesthesia-induced Hypotension In Elderly Patients Undergoing Infra-umbilical Surgeries. A Prospective Observational Study.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-08-14
Enrollment: 68
Sex: ALL
Minimum age (years): 65
Maximum age (years): 100
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: A total of 68 consecutive elderly patients, aged \>65 years scheduled for elective infra-umbilical surgical operations under spinal anesthesia will be included in the study.

Brief summary: Many previous studies have investigated the ability of various methods such as passive leg raising test , and inferior vena cava collapsibility index in predicting post-spinal hypotension, but none of them have succeeded in obtaining a good predictive value.

Our study aims to combine the passive leg raising test with the inferior vena cava distensibility index to aid in predicting post-spinal hypotension in elderly undergoing infra-umbilical surgeries.


Eligibility criteria: Inclusion Criteria:

* 1. 65 years of age or more. 2. ASA score I \& II. 3. Patients are scheduled for infra umbilical surgeries under spinal anesthesia.

Exclusion Criteria:

* Negative consent. Pre-existing hypertension Diabetes mellitus or autonomic neuropathy (patients diagnosed with autonomic neuropathy or having suggestive symptoms such as orthostatic hypotension, syncopal attacks, decreased sweating, and urinary incontinence) Emergency operations Absolute contraindications or failure to perform spinal anesthesia If PLR maneuver is contraindicated (intracranial hypertension) or possibly unreliable ( venous compression stocking, intraabdominal hypertension) Difficulties in IVC visualization due to increased subcutaneous fat tissue or gastric gas interferin

Primary outcomes:
measure: The sensitivity of Δmax.IVCd in predicting post-spinal anesthesia hypotension in elderly patients.
timeFrame: 15 minutes before spinal anesthesia
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03886363: Effectiveness of MBSR Among School Teachers
Official title: Effectiveness of Mindfulness-Based Stress Reduction Among Danish School Teachers
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Stress Reduction
Mental Well-being
Lead sponsor: University of Aarhus
Sponsor class: OTHER
First posted: 2019-03-22
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim is to evaluate the effectiveness of Mindfulness-Based Stress Reduction among school teachers in Danish schools on mental weii-being in the teachers and their pupils. The study is a cluster-randomised trial including 150 schools; 200 teachers; 4000 pupils from the five geographical regions in Denmark.


Eligibility criteria: Inclusion Criteria:

* School teacher at a Danish school that commit to participate in a trial aiming to implement and evaluate the effectiveness of ".b" (a school-based mindfulness programme)

Exclusion Criteria:

* acute treatment-demanding clinical depression or a diagnosis of psychosis or schizophrenia
* abuse of alcohol, drugs, medicine

Primary outcomes:
measure: Change in perceived stress among the school teachers
timeFrame: post MBSR (8 weeks from baseline), 6 and 12 months from baseline
measure: Change in resilience among the school teachers
timeFrame: post MBSR (8 weeks from baseline), 6 and 12 months from baseline
Secondary outcomes:
measure: Change in symptoms of anxiety and depression among the school teachers
timeFrame: post MBSR (8 weeks from baseline), 6 and 12 months from baseline
measure: Change in well-being among the school teachers
timeFrame: post MBSR (8 weeks from baseline), 6 and 12 months from baseline
measure: Change in mindfulness among the school teachers
timeFrame: post MBSR (8 weeks from baseline), 6 and 12 months from baseline
measure: Change in resting state among the school teachers
timeFrame: post MBSR (8 weeks from baseline), 6 and 12 months from baseline
measure: Change in social capital among the pupils spending >5 hours with the teachers
timeFrame: post MBSR (8 weeks from baseline)
measure: Change in strengths and difficulties among the pupils spending >5 hours with the teachers
timeFrame: post MBSR (8 weeks from baseline)
measure: Change in well-being among the pupils spending >5 hours with the teachers
timeFrame: post MBSR (8 weeks from baseline)
Other outcomes:
Locations:
city: Aarhus
country: Denmark
facility: Danish Center for Mindfulness
Study officials:
affiliation: Aarhus University, Danish Center for Mindfulness
name: Lone Fjorback, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05146063: LNK in Polycystic Ovary Syndrome With Insulin Resistance
Official title: LNK Participates in Insulin Resistance in Polycystic Ovary Syndrome by Regulating Adipose Glucose Transport
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Polycystic Ovarian Syndrome
Insulin Resistance
Lead sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2021-12-06
Enrollment: 80
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with polycystic ovary syndrome who met the 2003 Rotterdam criteria were divided into insulin resistance group and non-insulin resistance group

Brief summary: Insulin resistance (IR) is an important pathological feature of polycystic ovary syndrome (PCOS), with an incidence rate of up to 85%, which seriously affects the patient's fertility, quality of life, and offspring health, but the mechanism is unknown. The adaptor protein LNK is closely related to metabolic diseases. Our exome sequencing has found that the mutation rate of LNK gene in patients with PCOS and IR is high. Studies have found that LNK can affect adipose inflammation and impair glucose tolerance. Whether LNK is related to fat metabolism is worth further study. Our previous research found that: LNK expression was significantly increased in adipose tissue of patients with PCOS and IR. Knockout of LNK in PCOS IR model mice can reduce serum triglycerides, free fatty acids, high-sensitivity C-reactive protein levels and reduce fatty liver occurrence, which indicates that LNK has a mitigating effect on IR. Mechanism studies have shown that LNK knockout can upregulate the glucose transporter Glut4, also LNK and insulin receptor substrate IRS-1 can form protein complexes. Based on the above research basis, we propose the following scientific hypothesis: LNK in adipose tissue can regulate insulin signaling pathway by binding to IRS-1, downregulate Glut4, and participate in PCOS IR occurrence. This project intends to clarify the specific mechanism by which LNK regulates glucose transport and participate in IR in combination with clinical specimens, animal models and cell experiments, and provide scientific basis for LNK as a potential therapeutic target for PCOS IR.


Eligibility criteria: Inclusion Criteria:

* Patients with polycystic ovary syndrome who meet the 2003 Rotterdam criteria

Exclusion Criteria:

* Do not meet the diagnostic criteria for polycystic ovary syndrome

Primary outcomes:
measure: mRNA expression levels of LNK
timeFrame: 2 years
measure: protein expression levels of LNK
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Sun Yat-sen Memorial Hospital, Sun Yat-sen University
state: Guangdong
Study officials:
affiliation: Sun Yat-sen Memorial Hospital, Sun Yat-sen Univers
name: Yi Zhang
role: STUDY_DIRECTOR
References:
Clinical trial NCT00430963: IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines
Official title: A Prospective, Randomized, Double-blind, Placebo-controlled, Multicenter Trial With an Open-label Extension Period to Investigate the Efficacy and Safety of IncobotulinumtoxinA (Xeomin), Free of Complexing Proteins, in the Treatment of Glabellar Frown Lines
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Glabellar Frown Lines
Lead sponsor: Merz Pharmaceuticals GmbH
Sponsor class: INDUSTRY
First posted: 2007-02-02
Enrollment: 256
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: IncobotulinumtoxinA (Xeomin) is a botulinum toxin type A preparation free of complexing proteins, i.e. free of proteins other than the active toxin. Injected into the muscle, IncobotulinumtoxinA (Xeomin) causes local weakening. Botulinum toxin type A is widely used for aesthetic treatment of facial lines. This study investigated the efficacy and safety of IncobotulinumtoxinA (Xeomin) in the treatment of glabellar frown lines compared to placebo. The study consisted of a Main Period and an Open-Label Extension \[OLEX\] Period of 120 days each.


Eligibility criteria: Inclusion Criteria:

•Moderate to severe glabellar frown lines

Exclusion Criteria:

* Previous insertion of permanent material in the glabellar area
* Neuromuscular function disease

Primary outcomes:
measure: Investigator's assessment according to the Facial Wrinkle Scale (FWS)
timeFrame: Day 30
measure: Patient's global assessment
timeFrame: Day 30
Secondary outcomes:
measure: Investigator's assessment according to FWS
timeFrame: Day 7, 60, 90, and 120
measure: Patient's global assessment
timeFrame: Day 7, 60, 90, and 120
Other outcomes:
Locations:
city: Frankfurt
country: Germany
facility: Merz Pharmaceuticals GmbH
Study officials:
affiliation: Merz Pharmaceuticals GmbH
name: Medical Expert
role: STUDY_DIRECTOR
References:
Clinical trial NCT05954663: Clinical and Hemodynamic Evaluation After Venous Recanalization of Post-thrombotic Iliofemoral Syndromes
Official title: Clinical and Hemodynamic Evaluation After Venous Recanalization of Post-thrombotic Iliofemoral Syndromes
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Venous Recanalisation
Keywords: Post-thrombotic syndrome
Deep vein thrombosisA
Endovascular recanalization and stenting
Morphological and hemodynamic echodoppler criteria
Venous stent restenosis
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2023-07-20
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 67
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Population with a disabling post-thrombotic syndrome (venous claudication) after at least 6 months of proximal deep vein thrombosis.

Brief summary: Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT). The endovascular recanalization and stenting technique has become the gold standard treatment for medically resistant and disabling PTS.

Stent thrombosis is a significant complication of this procedure; the risk factors for thrombosis are poorly understood.

Monitoring the patency of the stent is a key component in maintaining clinical success.

Doppler ultrasound is the first-line diagnostic tool for monitoring patients with venous stents, and has the potential to allow accurate assessment of venous stent obstruction.

Absence of validated morphological and hemodynamic echodoppler criteria for the follow-up of these stents.

• Main objective: Clinical and hemodynamic results of venous recanalisations by stenting in the chronic phase

• Secondary objective (s):

* External validation of hemodynamic criteria proposed in the literature to detect venous stent obstruction
* Risk factors for venous stent restenosis


Eligibility criteria: Inclusion Criteria:

- Disabling post-thrombotic syndrome (venous claudication) after at least 6 months of proximal deep vein thrombosis.

Exclusion Criteria:

* Inability to consent
* Age \<18 years old
* Life expectancy \<3 months
* Incomplete medical records
* Lost in follow up

Primary outcomes:
measure: Clinical improvement
timeFrame: 6 first month post intervention
measure: Stent patency
timeFrame: 6 first month post intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Lyon
country: France
facility: Groupement Hospitalier Edouard Herriot
Study officials:
References:
Clinical trial NCT03922763: Fixed Inclination Humeral Cut
Official title: Does a Fixed Inclination Humeral Cut in Anatomic Total Shoulder Arthroplasty Effectively Recreate Normal Anatomy: A Prospective Randomized Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Shoulder Osteoarthritis
Lead sponsor: Rothman Institute Orthopaedics
Sponsor class: OTHER
First posted: 2019-04-22
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the present study is to determine if a standard humeral cut using a fixed neck shaft angled prosthesis for patients undergoing anatomic TSA is able to restore normal glenohumeral relationships as compared to a variable neck shaft angle prosthesis.


Eligibility criteria: Inclusion Criteria:

1. patients 18 years or older
2. primary glenohumeral osteoarthritis
3. intact rotator cuff
4. primary anatomic shoulder arthroplasty

Exclusion Criteria:

1. revision arthroplasty
2. reverse shoulder arthroplasty candidates
3. cognitive or behavioral problems which would preclude informed consent

Primary outcomes:
measure: Radriographic measurements
timeFrame: x-rays taken day of surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Rothman Institute
state: Pennsylvania
Study officials:
References:
Clinical trial NCT06717763: Surgery Following Immune Checkpoint Inhibitions for Controlled Disease in Recurrent or Metastatic dMMR/MSI-H Colorectal Cancer
Official title: Surgery Following Immune Checkpoint Inhibitions for Controlled Disease in Recurrent or Metastatic dMMR/MSI-H Colorectal Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Colorectal Cancer
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2024-12-05
Enrollment: 40
Sex: ALL
Minimum age (years): 16
Maximum age (years): 74
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The patients with recurrent or metastatic dMMR/MSI-H CRC who received PD-1 inhibition-based ICIs and subsequently underwent surgery from January 1, 2017 to July 1, 2023 at Sun Yat-sen University Cancer Center were entrolled.

Brief summary: Surgical resection for residual lesions could significantly improve the prognosis in metastatic colorectal cancers (CRCs) after systemic treatments, yet the necessity of resecting residual lesions after immune checkpoint inhibitions (ICIs) remains controversial in mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) diseases. We retrospectively enrolled recurrent or metastatic dMMR/MSI-H CRCs who received surgerys from Sun Yat-sen University Cancer Center. Patients without disease progression after at least 2 cycles of ICIs were included. Demographic and clinicopathological data were collected and analyzed. Relapse-free survival (RFS) after surgery were analyzed.


Eligibility criteria: Inclusion Criteria:

1. pathologically confirmed CRC with measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST, version 1.1)20;
2. definite pathological or radiological evidence of recurrent or distant metastasis;
3. received at least 2 courses of ICIs;
4. confirmed as dMMR by immunohistochemical method or MSI-H by polymerase chain reaction or next-generation sequencing;
5. receiving therapeutic surgical treatment for residual lesions or tumor sites and achieving no evidence of disease (NED) ;
6. no progression within the duration of preoperative ICIs

Exclusion Criteria:

-

Primary outcomes:
measure: Disease-free Survival
timeFrame: up to 5 years
measure: Overall Survival
timeFrame: up to 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Sun Yat-sen University, Cancer Center
state: Guangdong
Study officials:
References:
Clinical trial NCT02928263: Healthcare Cost and Resource Utilization Related to Metastatic Renal Cell Carcinoma Treatment With Intravenous and Oral Agents
Official title: A Healthcare Cost and Resource Utilization Analysis of Intravenous and Oral Agents in the Treatment of Metastatic Renal Cell Carcinoma
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Renal Cell Carcinoma
Lead sponsor: Bristol-Myers Squibb
Sponsor class: INDUSTRY
First posted: 2016-10-10
Enrollment: 0
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Metastatic RCC patients in the US identified from administrative claim databases

Brief summary: A retrospective study to evaluate healthcare cost and resource utilization for patients with metastatic renal cell carcinoma who have been treated with IV or oral agents


Eligibility criteria: Inclusion Criteria:

* Diagnosis with metastatic renal cell carcinoma
* Prescription/administration of one of the IV or oral agents examined in the study

Exclusion Criteria:

* Patients with other primary cancer diagnosis before RCC diagnosis
* Patients with pregnancy or HIV/AIDS

Primary outcomes:
measure: Distribution of Healthcare costs for patients treated with oral drugs used in the first-line treatment of Metastatic renal cell carcinoma (mRCC)
timeFrame: Up to 63 months
measure: Composite of Resource Utilization for patients treated with oral drugs used in the first-line treatment of mRCC
timeFrame: Up to 63 months
measure: Distribution of Healthcare costs for patients treated with IV drugs used in the first-line treatment of mRCC
timeFrame: Up to 63 months
measure: Composite of Resource Utilization for patients treated with IV drugs used in the first-line treatment of mRCC
timeFrame: Up to 63 months
Secondary outcomes:
measure: Medication Possession Ratio (MPR) for patients treated with oral drugs used in the first-line treatment of mRCC
timeFrame: Up to 63 months
measure: Medication Possession Ratio (MPR) for patients treated with IV drugs used in the first-line treatment of mRCC
timeFrame: Up to 63 months
Other outcomes:
Locations:
city: Princeton
country: United States
facility: Bristol-Myers Squibb
state: New Jersey
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References:
Clinical trial NCT03485235: Effect of Dilatation and Curettage on the Endometrial Receptivity
Official title: Effect of Dilatation and Curettage on the Endometrial Receptivity and Pregnancy Outcome in Patients With Recurrent Implantation Failure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Embryo Implantation
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2018-04-02
Enrollment: 160
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Effect of dilatation and curettage on the endometrial receptivity and pregnancy outcome in patients with recurrent implantation failure


Eligibility criteria: Inclusion Criteria:

1. All the patients had at least 3 failed trials of IVF-ET with day 5 fresh blastocyst transferred
2. At least 10 high-grade embryos were obtained in the previous trials
3. Level of AMH more than or equal 1.1 ng/ml.
4. Age: Less than or equal to 35 years

Exclusion Criteria:

1. Patients with uterine pathology e.g. myoma , Asherman syndrome, Septum ,adenomyosis
2. Hydrosalpinx
3. Endometriosis
4. patients with diagnosed autoimmune diseases affecting pregnancy e.g. S.L.E.

Primary outcomes:
measure: Live Birth Rate
timeFrame: 9 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University Maternity Hospital
Study officials:
References: