Clinical trial NCT05878769: A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
Official title: A Phase III Open-Label Extension Study to Evaluate the Long-Term Safety of Astegolimab in Patients With Chronic Obstructive Pulmonary Disease
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: chronic obstructive pulmonary disease, COPD
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2023-05-26
Enrollment: 2000
Sex: ALL
Minimum age (years): 40
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the long-term safety and to explore the efficacy of astegolimab in participants with chronic obstructive pulmonary disease (COPD) who have completed the 52-week placebo-controlled treatment period in parent studies GB43311 or GB44332.


Eligibility criteria: Inclusion Criteria:

* Completion of the 52-week treatment period in either parent GB43311 or GB44332

Exclusion Criteria:

* Withdrawal of consent and/or premature discontinuation from parent study
* Any permanent discontinuation of study drug in parent study
* Significant non-compliance in the parent study, specifically defined as missing scheduled visits, per investigator's judgment
* Any new diagnosis of asthma according to the Global Initiative for Asthma guidelines or other accepted guidelines since enrolling in the parent study
* Any new clinically significant pulmonary disease other than COPD (e.g., pulmonary fibrosis, sarcoidosis, chronic pulmonary embolism or primary pulmonary hypertension, alpha-1-antitrypsin deficiency) since enrolling in the parent study
* Any new unstable cardiac disease, myocardial infarction, or New York Heart Association Class III or IV heart failure since enrolling in the parent study

Primary outcomes:
measure: Incidence of all adverse events (AEs)
timeFrame: Up to 12 weeks after last dose of study treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: UAB Lung Health Center
state: Alabama
city: Dothan
country: United States
facility: SEC Clinical Research LLC - Dothan 2 - ClinEdge - PPDS
state: Alabama
city: Jasper
country: United States
facility: Jasper Summit Research LLC
state: Alabama
city: Mobile
country: United States
facility: Pulmonary Associates of Mobile PC
state: Alabama
city: Phoenix
country: United States
facility: Pulmonary Associates Deer Valley Office
state: Arizona
city: Tucson
country: United States
facility: AES - DRS - Synexus Clinical Research US, Inc. - Tucson
state: Arizona
city: Bakersfield
country: United States
facility: Kern Allergy and Medical Research
state: California
city: Poway
country: United States
facility: Cadena Care Institute, LLC
state: California
city: San Diego
country: United States
facility: Apex Clinical Research
state: California
city: Clearwater
country: United States
facility: St Francis Medical Institute ClinEdge PPDS
state: Florida
city: Greenacres City
country: United States
facility: Finlay Medical Research Corporation
state: Florida
city: Leesburg
country: United States
facility: Flourish Research - Leesburg - PPDS
state: Florida
city: Miami
country: United States
facility: San Marcus Research Clinic Inc.
state: Florida
city: Miami
country: United States
facility: Finlay Medical Research Corporation
state: Florida
city: Miami
country: United States
facility: Oceane7 Medical & Research Center, Inc.
state: Florida
city: Miami
country: United States
facility: Research Institute of South Florida Inc
state: Florida
city: Miami
country: United States
facility: Diverse Clinical Research, LLC
state: Florida
city: Orlando
country: United States
facility: Central Florida Pulmonary Group, PA
state: Florida
city: Orlando
country: United States
facility: Florida Institute for Clinical Research, LLC
state: Florida
city: Wellington
country: United States
facility: Pulmonary Specialists of the Palm Beaches
state: Florida
city: Winter Park
country: United States
facility: Flourish Research - Orlando - PPDS
state: Florida
city: Stonecrest
country: United States
facility: Pivotal Research Solutions
state: Georgia
city: Chicago
country: United States
facility: Northwestern Center for Clinical Research
state: Illinois
city: Hammond
country: United States
facility: ASHA Clinical Research - ClinEdge - PPDS
state: Indiana
city: New Orleans
country: United States
facility: George Stanley Walker, MD, LLC
state: Louisiana
city: Bangor
country: United States
facility: Paul A. Shapero, MD, PA
state: Maine
city: Fall River
country: United States
facility: Exordia Medical Research, Inc.
state: Massachusetts
city: Farmington Hills
country: United States
facility: Pulmonary Research Institute of Southeast Michigan
state: Michigan
city: Flint
country: United States
facility: Flushing Road Internal Medicine and Pediatrics - F
state: Michigan
city: Southfield
country: United States
facility: Revive Research Institute
state: Michigan
city: Troy
country: United States
facility: Oakland Medical Research
state: Michigan
city: Chesterfield
country: United States
facility: The Lung Research Center
state: Missouri
city: Hannibal
country: United States
facility: Hannibal Regional Healthcare System HRMG Hannibal
state: Missouri
city: Saint Charles
country: United States
facility: Midwest Chest Consultants
state: Missouri
city: Saint Louis
country: United States
facility: Washington University School of Medicine in St. Louis
state: Missouri
city: Saint Louis
country: United States
facility: Midwest Clinical Research LLC
state: Missouri
city: Las Vegas
country: United States
facility: The Machuca Foundation Inc
state: Nevada
city: Las Vegas
country: United States
facility: Sierra Clinical Research - ClinEdge - PPDS
state: Nevada
city: Reno
country: United States
facility: Renown Regional Medical Center Hospital
state: Nevada
city: New York
country: United States
facility: AES - DRS - Synexus Clinical Research US, Inc. - New York
state: New York
city: Charlotte
country: United States
facility: American Health Research Inc.
state: North Carolina
city: Denver
country: United States
facility: Research Carolina Elite
state: North Carolina
city: Gastonia
country: United States
facility: Clinical Research of Gastonia
state: North Carolina
city: Greensboro
country: United States
facility: Pulmonix LLC
state: North Carolina
city: Shelby
country: United States
facility: Carolina Research Center
state: North Carolina
city: Winston-Salem
country: United States
facility: Southeastern Research Center
state: North Carolina
city: Edmond
country: United States
facility: OK Clinical Research
state: Oklahoma
city: Portland
country: United States
facility: The Oregon Clinic.
state: Oregon
city: DuBois
country: United States
facility: Clinical Research Associates Of Central Pa , Llc
state: Pennsylvania
city: Philadelphia
country: United States
facility: Temple University Hospital
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Allergy & Clinical Immun Assoc
state: Pennsylvania
city: Columbia
country: United States
facility: Medtrial, LLC
state: South Carolina
city: Gaffney
country: United States
facility: Velocity Clinical Research - Gaffney - PPDS
state: South Carolina
city: North Charleston
country: United States
facility: Lowcountry Lung and Critical Care
state: South Carolina
city: Rock Hill
country: United States
facility: Clinical Research of Rock Hill
state: South Carolina
city: Chattanooga
country: United States
facility: ClinSearch, LLC
state: Tennessee
city: Hendersonville
country: United States
facility: Tennessee Comprehensive Lung & Sleep Center
state: Tennessee
city: Boerne
country: United States
facility: South Texas Medical Research Institute, Inc., dba TTS Research ? ClinEdge ? PPDS
state: Texas
city: Corsicana
country: United States
facility: Corsicana Medical Research
state: Texas
city: Houston
country: United States
facility: Trio Clinical Trials
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine
state: Texas
city: Houston
country: United States
facility: Houston Pulmonary Medicine Associates, PA - Biopharma Informatic, LLC
state: Texas
city: McKinney
country: United States
facility: Metroplex Pulmonary and Sleep Medicine Center
state: Texas
city: Sherman
country: United States
facility: Sherman Clinical Research - ClinEdge - PPDS
state: Texas
city: Colchester
country: United States
facility: Vermont Lung Center at the University of Vermont
state: Vermont
city: Charlottesville
country: United States
facility: University of Virginia Health System
state: Virginia
city: Everett
country: United States
facility: Western Washington Medical Group
state: Washington
city: Greenfield
country: United States
facility: Allergy Asthma and Sinus Center-Greenfield
state: Wisconsin
city: La Plata
country: Argentina
facility: Centro Medico Capital
state: Buenos Aires
city: Buenos Aires
country: Argentina
facility: Consultorios Medicos Organizacion de Buen Ayre SRL
city: Buenos Aires
country: Argentina
facility: Fundacion Cidea
city: Buenos Aires
country: Argentina
facility: Fundacion Faicep
city: Buenos Aires
country: Argentina
facility: Instituto de Investigaciones En Alergia Y Enfermedades Respiratorias
city: Caba
country: Argentina
facility: CARE - Centro de Alergia y Enfermedades Respiratorias
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Nexo Salud Investigacion Clinica - Riobamba 429
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: CINME S.A. ? Centro de Investigaciones Metabolicas - Rx Trials LLC
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Centro Médico Dra de Salvo
city: Ciudad Autonoma de Buenos Aires
country: Argentina
facility: AES - AS - Glenny Corp. S.A. Buenos Aires
city: Ciudad Autónoma De Buenos Aires
country: Argentina
facility: Centro de Investigaciones Clínicas Belgrano
city: Concepcion Del Uruguay
country: Argentina
facility: Centro de Medicina Respiratoria
city: Cordoba
country: Argentina
facility: Sanatorio de la Canada
city: Córdoba
country: Argentina
facility: Instituto de Medicina Respiratoria, IMeR
city: Entre Rios
country: Argentina
facility: Centro Privado de Medicina Respiratoria
city: La Plata
country: Argentina
facility: Framingham Centro Medico
city: La Plata
country: Argentina
facility: Centro Platense en Investigaciones Respiratorias
city: Lobos
country: Argentina
facility: Centro de Especialidades Medicas Lobos
city: Mar Del Plata
country: Argentina
facility: Centro de Investigaciones Medicas Mar Del Plata
city: Mar Del Plata
country: Argentina
facility: Instituto de Investigaciones Clinicas-Mar del Plata
city: Mar Del Plata
country: Argentina
facility: Instituto Ave Pulmo
city: Mendoza, Mendoza City
country: Argentina
facility: INSARES
city: Mendoza
country: Argentina
facility: Centro Medico Dharma
city: Mendoza
country: Argentina
facility: Fundacion Scherbovsky
city: Quilmes
country: Argentina
facility: Centro Respiratorio Quilmes
city: Ranelagh, Berazategui
country: Argentina
facility: Sala de primeros auxilios Alberto Mignaburu
city: Rosario
country: Argentina
facility: Instituto Medico de la Fundacion Estudios Clinicos
city: Rosario
country: Argentina
facility: Sanatorio Parque de Rosario
city: Rosario
country: Argentina
facility: Instituto Medico Fundacion Grupo Colaborativo Rosario Investigacion y Prevencion Medica
city: Rosario
country: Argentina
facility: Servicio de Investigacion de Patologias Alergicas-Instituto ABC
city: Rosario
country: Argentina
facility: Centro Medico IPAM
city: San Fernando
country: Argentina
facility: Centro Médico Respire
city: San Miguel de Tucuman
country: Argentina
facility: Instituto De Patologias Respiratorias
city: San Miguel de Tucuman
country: Argentina
facility: Centro Modelo de Cardiologia
city: San Miguel de Tucumán
country: Argentina
facility: Centro Integral de Medicina Respiratoria (CIMER)
city: San Nicolas de los Arroyos
country: Argentina
facility: Centro Medico San Nicolas Grupo Orono
city: San Salvador
country: Argentina
facility: CEPROSS- Centro Profesional San Salvador
city: Santa Fe
country: Argentina
facility: Instituto Del Buen Aire
city: Santa Fe
country: Argentina
facility: Centro de Diagnostico Y Rehabilitacion
city: Villa Vatteone
country: Argentina
facility: Instituto De Enfermedades Respiratorias E Investigacion Medica
city: Bedford Park
country: Australia
facility: Flinders Medical Centre
state: South Australia
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: Midland
country: Australia
facility: Institute for Respiratory Health Inc
state: Western Australia
city: Spearwood
country: Australia
facility: TrialsWest Pty Ltd
state: Western Australia
city: Feldbach
country: Austria
facility: Ordination Dr. Robert Voves
city: Linz
country: Austria
facility: Ordination fur Lungenkrankheiten
city: Brugge
country: Belgium
facility: AZ Sint-Jan Brugge-Oostende
city: Brussels
country: Belgium
facility: Universitair Ziekenhuis Brussel
city: Edegem
country: Belgium
facility: Antwerp University Hospital
city: Erpent
country: Belgium
facility: Private Practice Dr Jean Benoit Martinot
city: Leuven
country: Belgium
facility: UZ Leuven
city: Liège
country: Belgium
facility: CHU de Liège
city: Mechelen
country: Belgium
facility: AZ Sint-Maarten
city: Roeselare
country: Belgium
facility: AZ Delta
city: Thuin
country: Belgium
facility: Office of Marc De Meulemeester
city: Yvoir
country: Belgium
facility: CHU UCl Namur asbl - Site Godinne
city: Porto Alegre
country: Brazil
facility: LMK Servicos Medicos SS
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS)
state: Rio Grande Do Sul
city: Santo Andre
country: Brazil
facility: Faculdade de Medicina do ABC - FMABC
state: São Paulo
city: Sao Bernardo Do Campo
country: Brazil
facility: CEMEC - Centro Multidisciplinar de Estudos Clínicos
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: IBPCLIN Instituto Brasil de Pesquisa Clinica
city: Sofia
country: Bulgaria
facility: MHAT Knyaginya Klementina Sofia EAD
state: Sofia-Grad
city: Sofia
country: Bulgaria
facility: Diagnostic-Consultative Center Aleksandrovska EOOD
state: Sofia-Grad
city: Blagoevgrad
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Puls AD PPDS
city: Dimitrovgrad
country: Bulgaria
facility: Multiprofile Hospital For Active Treatment Sveta Ekaterina - Dimitrovgrad EOOD
city: Dupnitsa
country: Bulgaria
facility: Medical Centre "Asklepii", OOD
city: Haskovo
country: Bulgaria
facility: Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases - Haskovo EOOD
city: Lovech
country: Bulgaria
facility: Medical Centre Pratia EOOD branch Lovech
city: Montana
country: Bulgaria
facility: Medical Center Hera Eood
city: Pazardzhik
country: Bulgaria
facility: Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases-Dr.Nikola Penchev-Paza
city: Pernik
country: Bulgaria
facility: Specialized Hospital for Active Treatment of Pulmonary Diseases- Pernik EOOD
city: Pleven
country: Bulgaria
facility: Medical center Medconsult Pleven OOD
city: Plovdiv
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
city: Plovdiv
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Plovdiv
city: Plovdiv
country: Bulgaria
facility: Medical center Unimed EOOD
city: Shumen
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Shumen
city: Silistra
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment - Silistra AD
city: Smolyan
country: Bulgaria
facility: Multiprofile Hospital For Active Treatment - Dr. Bratan Shukerov AD
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov EAD
city: Sofia
country: Bulgaria
facility: Diagnostic- Consultative Center Convex EOOD
city: Sofia
country: Bulgaria
facility: AES DRS Medical Center Synexus Sofia EOOD
city: Stara Zagora
country: Bulgaria
facility: Medical Center New rehabilitation center EOOD
city: Varna
country: Bulgaria
facility: Medical Center Researchexpert OOD
city: Veliko Tarnovo
country: Bulgaria
facility: Medical Center Tara OOD
city: Vratsa
country: Bulgaria
facility: Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases-Vratsa
city: Edmonton
country: Canada
facility: Edmonton Respiratory Consultants
state: Alberta
city: Sherwood Park
country: Canada
facility: Synergy Respiratory & Cardiac Care - Synergy Wellness Centre Location
state: Alberta
city: Vancouver
country: Canada
facility: Vancouver General Hospital
state: British Columbia
city: Ajax
country: Canada
facility: Dynamic Drug Advancement Ltd.
state: Ontario
city: Burlington
country: Canada
facility: Burlington Lung Clinic
state: Ontario
city: Sarnia
country: Canada
facility: Bluewater Clinical Research Group
state: Ontario
city: Toronto
country: Canada
facility: Inspiration Research
state: Ontario
city: Windsor
country: Canada
facility: Dr. Syed Anees Medicine Profession Corporation
state: Ontario
city: Windsor
country: Canada
facility: Dr Anil Dhar Professional Medicine Corporation
state: Ontario
city: Saint-charles-borromee
country: Canada
facility: Clinique de pneumologie et du sommeil de Lanaudiere
state: Quebec
city: Quebec
country: Canada
facility: Centre Hospitalier de l'Universite Laval
city: Pavie Gallegos
country: Chile
facility: Centro Respiratorio Integral LTDA. (CENRESIN)
city: Providencia
country: Chile
facility: Centro de Investigaciones Medicas Respiratorias CIMER
city: Providencia
country: Chile
facility: Sociedad Médica SyG SpA
city: Providencia
country: Chile
facility: Enroll SpA - PPDS
city: Santiago
country: Chile
facility: Centro Internacional de Estudios Clínicos (CIEC)
city: Talca
country: Chile
facility: Centro de Investigacion del Maule
city: Valparaiso
country: Chile
facility: Hospital Carlos Van Buren
city: Vina Del Mar
country: Chile
facility: Centro de Investigacion de Enfermedades Respiratorias e Inmunologicas
city: Vitacura
country: Chile
facility: Fundacion Medica San Cristobal
city: Ñuñoa
country: Chile
facility: Centro de Estudios Clinicos
city: Zunyi
country: China
facility: Affiliated Hospital of Zunyi Medical University
state: Guizhou
city: Shanghai
country: China
facility: Huadong Hospital Affiliated of Fudan University
state: Shanghai
city: Beijing City
country: China
facility: Beijing Hospital
city: Beijing City
country: China
facility: Beijing Chaoyang Hospital Capital Medical University
city: Beijing City
country: China
facility: China-Japan Friendship Hospital
city: Beijing
country: China
facility: Beijing Jingmei Group General Hospital
city: Beijing
country: China
facility: Peking University Shougang Hospital
city: Changchun City
country: China
facility: The First Hospital of Jilin University
city: Changsha
country: China
facility: The First Hospital of Changsha
city: Changsha
country: China
facility: The Third Hospital of Changsha
city: Chengdu
country: China
facility: West China Hospital, Sichuan University
city: Chengdu
country: China
facility: Chengdu Fifth People's Hospital
city: Chongqing City
country: China
facility: Army Medical Center of PLA(Daping Hospital)
city: Guangdong
country: China
facility: Affiliated Hospital of Guangdong Medical University
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou Medical University
city: Guangzhou
country: China
facility: The Third Affiliated Hospital of Guangzhou Medical University
city: Guangzhou
country: China
facility: Guangzhou First People's Hospital
city: Hangzhou
country: China
facility: Hangzhou First People's Hospital
city: Hefei
country: China
facility: Anhui Chest Hospital
city: Huizhou
country: China
facility: Huizhou Central People's Hospital
city: Lianyungang
country: China
facility: The First People's Hospital of Lian Yun Gang
city: Linhai
country: China
facility: Taizhou Hospital of Zhejiang Province
city: Nanchang
country: China
facility: Jiangxi Provincial People's Hospital
city: Nanjing
country: China
facility: Zhongda Hospital Affiliated to Southeast University
city: Pingxiang
country: China
facility: Jiangxi Pingxiang People's Hospital
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
city: Wuhan
country: China
facility: Central Hospital of Wuhan
city: Wuxi City
country: China
facility: Wuxi People's Hospital
city: Wuxi
country: China
facility: Jiangyin People's Hospital
city: Xiamen
country: China
facility: Zhongshan Hospital Xiamen University
city: Xian
country: China
facility: Xi'an International Medical Center Hospital
city: Xinxiang
country: China
facility: Xinxiang First People's Hospital
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical University
city: Zhuhai City
country: China
facility: The Fifth Affiliated Hospital Sun Yat-Sen University
city: Zigong
country: China
facility: Zigong First People's Hospital
city: Brandys nad Labem-Stara Boleslav
country: Czechia
facility: Plicní ambulance MUDr. I. Cierná Peterová s.r.o.
city: Hradec Kralove
country: Czechia
facility: Fakultni nemocnice Hradec Kralove
city: Jind?ich?v Hradec
country: Czechia
facility: MediTrial s.r.o.
city: Kralupy nad Vltavou
country: Czechia
facility: Plicni Ambulance Kralupy nad Vltavou
city: Opava
country: Czechia
facility: Odborna plicni ambulance Opava s.r.o
city: Praha 1
country: Czechia
facility: Ordinace chorob plicních s.r.o.
city: Praha
country: Czechia
facility: AES - DRS - Synexus Czech s.r.o.
city: Tabor
country: Czechia
facility: Nemocnice Tabor, a.s.
city: Teplice
country: Czechia
facility: Plicni stredisko Teplice s.r.o.
city: Tábor
country: Czechia
facility: KASMED s.r.o.
city: Aalborg
country: Denmark
facility: Aalborg Universitetshospital
city: Hellerup
country: Denmark
facility: Gentofte Hospital
city: Hvidovre
country: Denmark
facility: Hvidovre Hospital
city: Odense C
country: Denmark
facility: Odense Universitetshospital
city: Roskilde
country: Denmark
facility: Sjaellands Universitetshospital, Roskilde
city: Vejle
country: Denmark
facility: Sygehus Lillebælt, Vejle
city: Amiens
country: France
facility: Clinique de l'Europe
city: Lyon
country: France
facility: Hôpital de La Croix Rousse
city: Marseille
country: France
facility: Hopital Saint Joseph - Marseille
city: Nice
country: France
facility: Hopital Pasteur II
city: Pessac
country: France
facility: Hopital Haut Leveque
city: Strasbourg
country: France
facility: Nouvel Hopital Civil - CHU Strasbourg
city: Augsburg
country: Germany
facility: Zentrum fuer Pneumologie, Onkologie und Schlafmedizin am Diako
city: Bamberg
country: Germany
facility: Gemeinschaftspraxis fuer Herz und Lunge am Bruderw
city: Bendorf
country: Germany
facility: KPPK Studienzentrum Kroker-Schmidt
city: Berlin
country: Germany
facility: Studienpraxis Berlin-Brandenburg, Berlin
city: Berlin
country: Germany
facility: Praxis fur Kardiologie und Pneumologie Dr. med. Karin Forster
city: Berlin
country: Germany
facility: MECS Research GmbH
city: Berlin
country: Germany
facility: AES - DRS - Synexus Berlin Research Centre
city: Berlin
country: Germany
facility: Clinical Studies Pankow
city: Darmstadt
country: Germany
facility: Lungenzentrum Darmstadt
city: Deggingen
country: Germany
facility: MVZ Jung GbR - Deggingen
city: Essen
country: Germany
facility: Medizentrum Essen Borbeck
city: Frankfurt am Main
country: Germany
facility: Praxis Dr med Claus Keller
city: Frankfurt
country: Germany
facility: Universitaetsklinikum Frankfurt
city: Hamburg
country: Germany
facility: ME Clinical Respiratory Research Hamburg GmbH
city: Hannover
country: Germany
facility: Pneumologicum
city: Heidelberg
country: Germany
facility: University Clinic Heidelberg
city: Immenhausen
country: Germany
facility: Lungenfachklinik Immenhausen
city: Landsberg
country: Germany
facility: Asklepios MVZ Bayern GmbH
city: Leipzig
country: Germany
facility: Salvus-Klinische Studien GmbH
city: Leipzig
country: Germany
facility: BAG Prof. Dr. G. Hoheisel Dr. A. Bonitz
city: Lübeck
country: Germany
facility: KLB Gesundheitsforschung Lubeck GmbH
city: Magdeburg
country: Germany
facility: SMO.MD GmbH
city: Mainz
country: Germany
facility: IKF Pneumologie Mainz
city: Marburg
country: Germany
facility: Praxis für Pneumologie Dr. Silke Mronga & Dr. Lukas Jerrentrup
city: München
country: Germany
facility: Praxis Dr. med. Jan Feimer
city: Neu-Isenburg
country: Germany
facility: Institut fur klinische Forschung GmbH
city: Peine
country: Germany
facility: Studienzentrum Dr Med Schlenska
city: Rheine
country: Germany
facility: framol-med GmbH
city: Rosenheim
country: Germany
facility: RoMed Klinikum Rosenheim-Pettenkoferstr. 10
city: Athens
country: Greece
facility: Evangelismos General Hospital of Athens
city: Athens
country: Greece
facility: Iatriko Palaiou Falirou
city: Athina
country: Greece
facility: Navy Hospital of Athens
city: Herakleion
country: Greece
facility: University General Hospital of Heraklion
city: Ioannina
country: Greece
facility: University General Hospital of Ioannina
city: Thessaloniki
country: Greece
facility: Georgios Papanikolaou General Hospital of Thessaloniki
city: Hong Kong
country: Hong Kong
facility: Tuen Mun Hospital
city: Budapest
country: Hungary
facility: Obudai Egeszsegugyi Centrum Kft.-Budapest
city: Hyderabad
country: India
facility: Paarthiv Lung Care Center
state: Andhra Pradesh
city: Hyderabad
country: India
facility: Yashoda Hospitals Hitec City
state: Andhra Pradesh
city: Hubli
country: India
facility: Karnataka Institute of Medical Sciences (KIMS), Hubbali
state: Karnataka
city: Nagpur
country: India
facility: Shree Hospital And Critical Care Centre
state: Maharashtra
city: Pune City
country: India
facility: Kothrud Hospital
state: Maharashtra
city: Ajmer
country: India
facility: Jawaharlal Nehru Medical College (JNMC)
state: Rajasthan
city: Jaipur
country: India
facility: Sawai Man Singh Hospital and Medical College
state: Rajasthan
city: Jaipur
country: India
facility: Maharaja Agrasen Super Speciality Hospital
state: Rajasthan
city: Aligarh
country: India
facility: Jawaharlal Nehru Medical College (JNMC)
state: Uttar Pradesh
city: Kanpur
country: India
facility: Apollo Spectra Hospital
state: Uttar Pradesh
city: Lucknow
country: India
facility: MV Hospital and Research Centre
state: Uttar Pradesh
city: Ashdod
country: Israel
facility: Assuta Ashdod Medical Center
city: Ashkelon
country: Israel
facility: Barzilai Medical Center
city: Be'er Ya'akov
country: Israel
facility: Shamir Medical Center Assaf Harofeh
city: Beer Sheva
country: Israel
facility: Soroka University Medical Centre
city: Haifa
country: Israel
facility: Rambam Medical Center - PPDS
city: Haifa
country: Israel
facility: Lady Davis Carmel Medical Center
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
city: Jerusalem
country: Israel
facility: Hadassah Medical Center
city: Kfar- Saba
country: Israel
facility: Meir Medical Center
city: Petach Tiqwa
country: Israel
facility: Rabin Medical Center
city: Ramat Gan
country: Israel
facility: Sheba Medical Center - PPDS
city: Rehovot
country: Israel
facility: Kaplan Medical Center
city: Tel Aviv-Yafo
country: Israel
facility: Tel Aviv Sourasky Medical Center PPDS
city: Napoli
country: Italy
facility: Azienda Ospedaliera Dei Colli
state: Campania
city: Cona, Ferrara
country: Italy
facility: Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant' Anna
state: Emilia-Romagna
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico San Matteo di Pavia
state: Lombardia
city: Catania
country: Italy
facility: Azienda Ospedaliero Universitaria Policlinico G.Rodolico - San Marco
state: Sicilia
city: Palermo
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
state: Sicilia
city: Takamatsu
country: Japan
facility: Kamei Internal Medicine and Respiratory Clinic
city: Kilifi
country: Kenya
facility: KEMRI-MTWAPA Clinical Trial Site
city: Machakos
country: Kenya
facility: Clinical Research Health Network (CREA-N)
city: Nairobi
country: Kenya
facility: KEMRI CRDR Clinical Research Clinic Nairobi
city: Nairobi
country: Kenya
facility: University of Nairobi Clinical Research Centre
city: Thika
country: Kenya
facility: Center for Research In Tropical Medicine and community development
city: Bucheon-si,
country: Korea, Republic of
facility: Soon Chun Hyang University Hospital Bucheon
city: Daegu
country: Korea, Republic of
facility: Yeungnam University Hospital
city: Gyeonggi-do
country: Korea, Republic of
facility: CHA Bundang Medical Center
city: Incheon
country: Korea, Republic of
facility: Catholic Univ. of Incheon St.Mary's Hospital
city: Jeollabuk-do
country: Korea, Republic of
facility: Chonbuk National University Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center - PPDS
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center - PPDS
city: Seoul
country: Korea, Republic of
facility: Chung-Ang University Hospital
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St. Mary's Hospital
city: Wonju-Si
country: Korea, Republic of
facility: Yonsei University Wonju Severance Christian Hospital
city: Daugavpils
country: Latvia
facility: Daugavpils Regional Hospital
city: R?ga
country: Latvia
facility: Pauls Stradins Clinical University Hospital
city: Riga
country: Latvia
facility: Riga 1st Hospital
city: Riga
country: Latvia
facility: ConsiliumMedicum
city: Americana
country: Mexico
facility: CICUM San Miguel
state: Jalisco
city: Santa Cecilia
country: Mexico
facility: Instituto Jalisciense de Investigacion Clinica S.A. de C.V.
state: Jalisco
city: Guadalajara
country: Mexico
facility: Unidad Medica de Occidente
city: Monterrey
country: Mexico
facility: Unidad de Investigacion Clinica En Medicina (Udicem) S.C.
city: Amersfoort
country: Netherlands
facility: Meander Medisch Centrum
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis
city: Eindhoven
country: Netherlands
facility: Catharina Hospital
city: Hoorn
country: Netherlands
facility: Dijklander Ziekenhuis - loc Hoorn
city: Zwolle
country: Netherlands
facility: Isala Klinieken
city: Auckland
country: New Zealand
facility: Greenlane Clinical Centre
city: Auckland
country: New Zealand
facility: NZ Respiratory & Sleep Institute
city: Auckland
country: New Zealand
facility: Aotearoa Clinical Trials Trust
city: Christchurch
country: New Zealand
facility: Canterbury Respiratory Research Group
city: Dunedin
country: New Zealand
facility: Dunedin Hospital
city: Hamilton
country: New Zealand
facility: Waikato Hospital
city: Paraparaumu
country: New Zealand
facility: P3 Research - Kapiti - PPDS
city: San Miguel
country: Peru
facility: Clinica Providencia (Inverconsult Sociedad Anonima) - PPDS
state: Lima
city: Lima
country: Peru
facility: Clinica Internacional - PPDS
city: Lima
country: Peru
facility: Medicentro Biociencias Peru S.R.L.
city: San Isidro
country: Peru
facility: Clinica Ricardo Palma - PPDS
city: Caloocan City
country: Philippines
facility: Manila Central University-Filemon D Tanchoco Medical Foundation
city: Dasmarinas
country: Philippines
facility: CARE CT Group Inc.
city: Iloilo City
country: Philippines
facility: Healthlink Medicalsurgicaldental Clinic and Diagnostic Center
city: Iloilo City
country: Philippines
facility: West Visayas State University Medical Center
city: Lipa City
country: Philippines
facility: Mary Mediatrix Medical Center
city: Quezon City
country: Philippines
facility: Philippine Heart Center
city: Quezon City
country: Philippines
facility: Quirino Memorial Medical Center
city: Wroclaw
country: Poland
facility: Lekarze Specjalisci J. Malolepszy i Partnerzy
state: Dolnoslaskie
city: Lodz
country: Poland
facility: AppleTreeClinics Network Sp. z o.o.
state: Lódzkie
city: Lodz
country: Poland
facility: Prywatny Gabinet Lekarski Ginekologia i Poloznictwo Ultrasonografia Prof. Jacek Suzin
state: Lódzkie
city: Bia?ystok
country: Poland
facility: Centrum Medycyny Oddechowej Mroz sp. j.
city: Bydgoszcz
country: Poland
facility: Vitamed Galaj i Cichomski sp.j.
city: Bydgoszcz
country: Poland
facility: Medical Center Kermed
city: Bydgoszcz
country: Poland
facility: Centrum Medyczne Bydgoszcz- PRATIA - PPDS
city: Chojnice
country: Poland
facility: Centrum Medyczne Lukamed Joanna Luka-Wendrowska
city: Gdynia
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Gdyni
city: Grudzadz
country: Poland
facility: Centrum Medyczne CLW-med Aneta Cichomska , Joanna Luka -Wendrowska
city: Katowice
country: Poland
facility: Centrum Medyczne Katowice - PRATIA - PPDS
city: Kielce
country: Poland
facility: Indywidualna Specjalistyczna Praktyka Lekarska lek.
city: Krakow
country: Poland
facility: Centrum Medyczne ALL-MED
city: Kraków
country: Poland
facility: Diamond Clinic
city: Kraków
country: Poland
facility: Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o. sp.k.
city: Ksawerow
country: Poland
facility: Praktyka Lekarska Adam Smialowski
city: Lodz
country: Poland
facility: AES - DRS - Synexus Polska Sp. Z o.o. Oddzial w Lodzi
city: Lodz
country: Poland
facility: ETG Lodz
city: Lublin
country: Poland
facility: Clinical Best Solutions - Lublin
city: Lublin
country: Poland
facility: NZOZ Przychodnia Alergologiczno-pulmonologiczna
city: Lublin
country: Poland
facility: ETG Lublin
city: Nowa Sól
country: Poland
facility: Twoja Przychodnia Centrum Medyczne Nowa Sol
city: Ostrowiec Swietokrzysk
country: Poland
facility: Ostrowieckie Centrum Medyczne Spolka Cywilna Anna Olec-Cudzik
city: Poznan
country: Poland
facility: Centrum Alergologii Teresa Hofman
city: Radom
country: Poland
facility: ABC-Pulmo NZOZ Agnieszka Dobielska, Jaroslaw Dobie
city: Rzeszów
country: Poland
facility: EMED Centrum Uslug Medycznych Ewa Smialek
city: Siedlce
country: Poland
facility: ETG Siedlce
city: Sopot
country: Poland
facility: Centrum Medyczne KARDIOTEL
city: Sosnowiec
country: Poland
facility: Kiepury Clinic
city: Sosnowiec
country: Poland
facility: PULMAG Grzegorz Gasior Marzena Kociolek Spolka Cywilna
city: Szczecin
country: Poland
facility: Gabinet Pulmonologii i Diagnostyki Chorob Alergicznych Dorota Malosek
city: Tarnow
country: Poland
facility: CenterMed Bandrowskiego
city: Trzebnica
country: Poland
facility: Viltis Medica Specjalistyczna Praktyka Lekarska Lek. Med. Agata Kot
city: Warszawa
country: Poland
facility: AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Warszawie
city: Wroc?aw
country: Poland
facility: Dobrostan Gabinety Lekarskie
city: Wroclaw
country: Poland
facility: Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska
city: Guaynabo
country: Puerto Rico
facility: Allianze Pulmonary Research LLC
city: Brasov
country: Romania
facility: Neomed Out-Patient Treatment and Diagnosis Medical Center SRL
city: Bucharest
country: Romania
facility: Dr. Victor Babes Foundation
city: Cluj-Napoca
country: Romania
facility: Leon Daniello Pneumophthisiology Clinical Hospital
city: Suceava
country: Romania
facility: Sf. Ioan cel Nou Emergency County Hospital
city: City Of Tshwane
country: South Africa
facility: Johese Clinical Research
state: Gauteng
city: Bloemfontein
country: South Africa
facility: Iatros International
city: Cape Town
country: South Africa
facility: University of Cape Town Lung Institute
city: City Of Cape Town
country: South Africa
facility: Dr. Ismail Abdullah Private Practice
city: City Of Johannesburg
country: South Africa
facility: Newtown Clinical Research Centre
city: City Of Tshwane
country: South Africa
facility: Clinical Trial Systems
city: Ekurhuleni
country: South Africa
facility: Lakeview Hospital
city: Ekurhuleni
country: South Africa
facility: Dr A.C Wilhase practice-Reimed
city: Ethekwini
country: South Africa
facility: St Augustines Hospital
city: Kempton Park
country: South Africa
facility: CLINRESCO, ARWYP Medical Suites
city: Kraaifontein
country: South Africa
facility: Langeberg Clinical Trials
city: Pretoria
country: South Africa
facility: Medicross Pretoria West, Jongaie Research
city: Pretoria
country: South Africa
facility: AES - DRS - Synexus Watermeyer Clinical Research Centre
city: Somerset West
country: South Africa
facility: AES - DRS - Synexus - Helderberg Clinical Research Centre
city: Welkom
country: South Africa
facility: Dr Yacoob AK Private Practice
city: Merida
country: Spain
facility: Hospital de Merida
state: Badajoz
city: Santander
country: Spain
facility: Hospital Universitario Marques de Valdecilla
state: Cantabria
city: Palma de Mallorca
country: Spain
facility: Hospital Universitario Son Espases
state: Islas Baleares
city: Santiago de Compostela
country: Spain
facility: Hospital Clinico Universitario de Santiago
state: LA Coruna
city: Torrejon de Ardoz
country: Spain
facility: Hospital Universitario de Torrejon
state: Madrid
city: Benalmadena Costa
country: Spain
facility: Vithas Xanit International Hospital
state: Malaga
city: Alzira
country: Spain
facility: Hospital de La Ribera
state: Valencia
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
city: Granada
country: Spain
facility: Hospital Universitario Virgen de Las Nieves
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Maranon
city: Madrid
country: Spain
facility: Hospital Universitario Fundacion Jimenez Diaz.
city: Madrid
country: Spain
facility: Hospital Universitario La Paz - PPDS
city: Malaga
country: Spain
facility: Hospital Universitario Virgen de la Victoria
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia
city: Lidingö
country: Sweden
facility: Fysikalisk Medicin i Stockholm AB
city: Linkoping
country: Sweden
facility: Clinical Trial Consultants - Linkoping
city: Malmö
country: Sweden
facility: PharmaSite
city: Stockholm
country: Sweden
facility: Akardo AB
city: Stockholm
country: Sweden
facility: ProbarE i Stockholm AB
city: Zurich
country: Switzerland
facility: Zurcher Reha Zentren Wald
city: Chang Hua
country: Taiwan
facility: Changhua Christian Hospital
city: Kaoshiung City
country: Taiwan
facility: Kaohsiung Medical University Hospital
city: New Taipei
country: Taiwan
facility: Far East Memorial Hospital
city: Taipei City
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taipei
country: Taiwan
facility: Taipei Medical University Hospital
city: Taipei
country: Taiwan
facility: Tri-Service General Hospital
city: Khon Kaen
country: Thailand
facility: Srinagarind Hospital, Khon Kaen University
city: Muang
country: Thailand
facility: Central Chest Institute of Thailand
city: Adana
country: Turkey
facility: Cukurova University Medical Faculty Balcali Hospital
city: Kirikkale
country: Turkey
facility: Kirikkale Universitesi Tip Fakultesi Hastanesi
city: Rize Merkez
country: Turkey
facility: Rize Recep Tayyip Erdogan University Training and Research Hospital
city: London
country: United Kingdom
facility: Guys Hospital
state: Middlesex
city: Bellshill
country: United Kingdom
facility: AES - DRS - Synexus Scotland Clinical Research Centre
city: Bradford
country: United Kingdom
facility: Bradford Royal Infirmary
city: Cambridge
country: United Kingdom
facility: Addenbrookes Hospital
city: Cardiff
country: United Kingdom
facility: AES - DRS - Synexus Wales Clinical Research Centre
city: Chesterfield
country: United Kingdom
facility: Royal Primary Care - Ashgate Manor
city: Chorley
country: United Kingdom
facility: AES - DRS - NW Consortium Lancashire
city: Cottingham
country: United Kingdom
facility: Castle Hill Hospital
city: Edgbaston
country: United Kingdom
facility: AES - DRS - Synexus Midlands Clinical Research Centre
city: Hexham
country: United Kingdom
facility: AES - DRS - Synexus Hexham Clinical Research Centre
city: Leicester
country: United Kingdom
facility: Glenfield Hospital
city: Liverpool
country: United Kingdom
facility: AES - DRS - NW Consortium Merseyside
city: London
country: United Kingdom
facility: Velocity Clinical Research North London - Percy Road - PPDS
city: London
country: United Kingdom
facility: Queen Anne Street Medical Centre
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References: