Clinical trial NCT03978169: Pulmonary Impacts of Anaesthetic Modalities Evaluated by Ultrasound
Official title: Pulmonary Impacts of Anaesthetic Modalities Evaluated by Ultrasound: A Prospective Study in Scheduled Knee Arthroplasty
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Anesthesia
Keywords: anaesthetic modality
Lung
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2019-06-07
Enrollment: 99
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient undergoing scheduled primary knee arthroplasty

Brief summary: A prospective, observational, monocentric study aimed at identifying ultrasound changes in anaesthesia on the pulmonary parenchyma after knee arthroplastic surgery using the LUS score in the preoperative, immediate post-operative (D0) and late post-operative (D1) periods.

Detailed description: Post-operative pulmonary complications are responsible from morbidity and mortality close to cardiovascular complications.

Perioperative and post-operative respiratory changes are secondary to anaesthesia (general anaesthesia, elongated position, tidal volume) and to surgery in particular abdominal and cardiothoracic surgery.

Several risk factors related to patients were identified: age, ASA score\> 2, functional dependence, chronic obstructive pulmonary disease, congestive heart failure, obesity, smoking.

Pulmonary ultrasound is a simple and rapid means of monitoring, widely used in resuscitation and developing in anaesthesia.

The hypothesis of the study is that anaesthesia and / or ventilation is responsible for lung lesions observable by ultrasound from the recovery room, even after extra-thoracic surgeries.

To do this, it will perform 3 pleuro-pulmonary ultrasound scans, preoperatively on the day of surgery, post-operatively in the recovery room and the day after surgery. LUS score will be calculated. Preoperative data (morphology, comorbidities), preoperative (ventilation, filling, position, type of anaesthesia - general anaesthesia with intubation or laryngeal mask, spinal anaesthesia- , type of surgery) and postoperative data (constants, oxygen therapy, complications) will be collected.

Eligibility criteria: Inclusion Criteria:

* Patient undergoing scheduled primary knee arthroplasty :
* Partial knee replacement surgery
* Total knee replacement surgery

  • Type of Anaesthesia
* General anaesthesia with orotracheal intubation
* General anaesthesia with laryngeal mask
* Spinal anaesthesia

  * Major Patient
  * Oral non opposition collected after oral information of the study

Exclusion Criteria:

* Refusal to participate
* Preoperative pleural pathology (pleural effusion, pleural symphysis)
* Pregnancy
* Patient under authorship or curators
* non-affiliation to a social security scheme

Primary outcomes:
measure: lung lesions by the anaesthetic and operative management after knee replacement surgery
timeFrame: 10 minutes before surgery
measure: lung lesions by the anaesthetic and operative management after knee replacement surgery
timeFrame: 10 minutes post surgery
measure: lung lesions by the anaesthetic and operative management after knee replacement surgery
timeFrame: 24hours post surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Toulouse
country: France
facility: UHToulouse
Study officials:
affiliation: University Hospital, Toulouse
name: Fabrice FERRE, MD
role: PRINCIPAL_INVESTIGATOR
References: