louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05252663: Effect of Intrathorathic Oscillations on Pulmonary Functions in Children With Cerebral Palsy
Official title: Effect of Intrathorathic Oscillations on Pulmonary Functions in Children With Cerebral Palsy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebral Palsy
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-02-23
Enrollment: 24
Sex: ALL
Minimum age (years): 6
Maximum age (years): 8
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aim: To investigate the effect of intrathoracic oscillations on forced expiratory volume at first second and peak expiratory flow in the children with cerebral palsy.

Methods and Procedures: Children were randomly assigned into two groups (study group and control group). Each child was evaluated before and after 6 successive weeks.

Detailed description: Methods and Procedures: 24 children with spastic cerebral palsy from both sexes, There ages from 6 to 8 years old. Children were randomly assigned into two groups (study group and control group). Each child was evaluated before and after 6 successive weeks. The children of the control group received traditional chest physiotherapy. while, the children of the study group received 4 sessions per week for 6 weeks with quake device.

Eligibility criteria: Inclusion Criteria:

* children with cerebral palsy
* Age from 6 to 8 years old
* the degree of spasticity from 2 to 2+
* grade 4, 5 according to GMFCs

Exclusion Criteria:

* Uncontrolled convulsions
* Any psychiatric disorders

Primary outcomes:
measure: FEV1
timeFrame: After 6 weeks
measure: PEF
timeFrame: After 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Physical Therapy, Cairo University
city: Cairo
country: Egypt
facility: Faculty of physical therapy, Cairo university
Study officials:
affiliation: Cairo University
name: Mai Abbass, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01795963: ePREP for Community Couples
Official title: ePREP for Community Couples
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intimate Partner Violence
Keywords: intimate partner violence
Lead sponsor: Brigham Young University
Sponsor class: OTHER
Collaborators: name: Florida State University
name: Department of Health and Human Services
First posted: 2013-02-21
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of the present study is to examine the impact of ePREP when it is administered to couples. More specifically, investigators will test whether--compared to placebo controls--participants who receive ePREP will experience better outcomes for relationship relevant variables.


Eligibility criteria: Inclusion Criteria:

* Only those who are married or who have been in a committed romantic relationship for six months or longer will be invited to participate.

Exclusion Criteria:

* The only exclusionary criteria were inability to read study questionnaires and unwillingness to access the internet to receive e-mail instructions on weekly homework assignments.

Primary outcomes:
measure: Revised Conflict Tactics Scale (CTS-2)
timeFrame: Change across three time-points: baseline, 6-week follow up and 1-year follow up
measure: Communication Patterns Questionnaire (CPQ)
timeFrame: Change across three time-points: baseline, 6-week follow up and 1-year follow up
Secondary outcomes:
Other outcomes:
Locations:
city: Tallahassee
country: United States
facility: Florida State University
state: Florida
Study officials:
affiliation: Brigham Young University
name: Scott R Braithwaite, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01409863: Fractional Laser Therapy and Dermabrasion for Scar Revision
Official title: A Comparison Evaluation of Fractional Laser Therapy an Dermabrasion for Scar Revision
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Scar
Keywords: post surgical or post traumatic scar on face or scalp
Lead sponsor: University of Minnesota
Sponsor class: OTHER
First posted: 2011-08-04
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The goals of this study will be to compare the safety and efficacy of fractional photothermolysis (Fraxel) with dermabrasion when used for scar revision.

Detailed description: Post traumatic and post surgical scar resurfacing is a common reason for patient visits to dermatologists and plastic surgeons. The Fraxel Laser is a new FDA cleared treatment for textural irregularities of the skin. There have been no studies examining the efficacy of Fraxel specifically for scar resurfacing though it is being used in clinical practice as its clearance was given under hte umbrella of "coagulation of soft tissue." Dermabrasion is the gold standard for scar resurfacing and provides the criterion against which Fraxel therapy should be measured.

Eligibility criteria: Inclusion Criteria:

* post surgical or post traumatic scar on face or scalp
* age 18 or older
* able to read and comprehend English
* Willing to follow treatment schedule and post treatment care requirements
* signed informed consent form
* Fitzpatrick skin type I-III

Exclusion Criteria:

* known photosensitivity
* taken any medications known to induce photosensitivity in previous three months
* taken accutane within past 12 months
* pregnant or nursing
* currently on topical or oral antibiotics
* immunocompromised status
* skin type IV or greater

Primary outcomes:
measure: safety and efficacy of fractional photothermolysis
timeFrame: Post Surgery
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of Minnesota
name: John Christophel, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00875563: Zenith(R) Fenestrated Abdominal Aortic Aneurysm (AAA) Endovascular Graft Clinical Study
Official title: Evaluation of the Safety and Effectiveness of the Zenith(R) Fenestrated AAA Endovascular Graft
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Abdominal Aortic Aneurysms
Aorto-iliac Aneurysms
Juxtarenal Aneurysms
Lead sponsor: Cook Group Incorporated
Sponsor class: INDUSTRY
First posted: 2009-04-03
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The Zenith(R) Fenestrated AAA Endovascular Graft Clinical Study is a clinical investigation approved by the US FDA to study the safety and effectiveness of the Zenith(R) Fenestrated AAA Endovascular Graft in the treatment of abdominal aortic and aorto-iliac aneurysms.


Eligibility criteria: Inclusion Criteria:

* Abdominal aortic and aortoiliac aneurysms with diameter greater than or equal to 5 cm

Exclusion Criteria:

* Proximal neck less than 4 mm or greater than or equal to 15 mm in length unless otherwise compromised to preclude seal
* Renal artery stenosis greater than 50 percent

Primary outcomes:
measure: Number of Participants With Treatment Success
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: University of California, San Francisco
state: California
city: Gainesville
country: United States
facility: Shands Hospital
state: Florida
city: Indianapolis
country: United States
facility: The Indiana Heart Hospital
state: Indiana
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Worcester
country: United States
facility: University of Massachusetts
state: Massachusetts
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
city: St. Louis
country: United States
facility: Barnes-Jewish Hospital
state: Missouri
city: Lebanon
country: United States
facility: Dartmouth Hitchcock Medical Center
state: New Hampshire
city: New York
country: United States
facility: NYU Medical Center
state: New York
city: Chapel Hill
country: United States
facility: University of North Carolina
state: North Carolina
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
city: Philadelphia
country: United States
facility: Hospital of the University of Pennsylvania
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh Medical Center
state: Pennsylvania
city: Seattle
country: United States
facility: Harborview Medical Center
state: Washington
Study officials:
References:
Clinical trial NCT02993263: Postoperative Acute Myocardial Ischemic Injury
Official title: Detection and Prediction of Postoperative Acute Myocardial Ischemic Injury/Infarction by the VectraplexECG System With CEB®
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Myocardial Infarction
Lead sponsor: The Cleveland Clinic
Sponsor class: OTHER
First posted: 2016-12-15
Enrollment: 323
Sex: ALL
Minimum age (years): 45
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The investigators propose to estimate the sensitivity and specificity of the VectraplexECG System for detecting acute myocardial ischemic injury, including acute myocardial infarctions after major non-cardiac surgery.

A 10 second CEB dynamic sequence recording will be obtained immediately after surgery in the post-anesthesia care unit.

On the first, second and third post operative morning a 10 second CEB dynamic sequence will be recorded. Blood will be sampled for troponin as well.

On the first, second and third post operative afternoons a 10 second CEB dynamic sequence will be recorded.

The morning 10 second CEB dynamic sequence and blood draw for troponin will continue as long as the patient remains hospitalized. The afternoon 10 second CEB dynamic sequence will continue as long as the patient remains hospitalized.


Eligibility criteria: Inclusion Criteria:

1. Written informed consent.
2. ≥ 45 years old.
3. Anticipated hospitalization of at least two nights.

Exclusion Criteria:

1. Inadequate ECGs, based on an initial 10-second trace, as defined by:

   * wandering baseline
   * excessive noise
   * ventricular ectopy
   * pacer spikes or
   * lead placement error
2. Atrial fibrillation.
3. Average heart rate exceeding 90 beats/minute.
4. Evidence of previous myocardial infarction:

   * Pathologic Q waves (≥0.04 sec) and/or
   * Pathologic findings of a healed or healing MI and/or
   * Evidence from an imaging study of a region of loss of viable myocardium

Primary outcomes:
measure: Accuracy
timeFrame: 1 minute to complete the test
Secondary outcomes:
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
Study officials:
affiliation: The Cleveland Clinic
name: Daniel Sessler, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03097263: Is the Walking Velocity an Efficient Outcome of Rehabilitation Program in Non- Specific Low Back Pain Patient
Official title: Is the Walking Velocity an Efficient Outcome of Rehabilitation Program in Non- Specific Low Back Pain Patient
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Non-specific Low Back Pain
Functional Capacities
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2017-03-31
Enrollment: 127
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Non-specific low back pain patients included for rehabilitation program

Brief summary: Despite the prevalence of chronic low back pain, functional symptomatology of this disease remains poor and treatment decisions are based mainly on subjective data (importance and pain tolerance). However, there are some experimental elements that involve objective assessment of locomotor capabilities - at forefront objectives which the walking velocity in the evaluation of this pathology in terms of severity of functional impairment. Recent evidence suggest the effectiveness of physical rehabilitation program for improving patients functional capacities and their reintegration in socio-professional life. This retrospective study aims to quantify the evolution of the parameters collected during standardized walking tests performed before and after rehabilitation program. These patients have systematically carry out a comfortable walk test (400m walk test) and a brisk walk test (200m) at the beginning and end of their program. Furthermore, a maximal stress test on a treadmill was performed before the program in order to detect any cardiovascular events and to allow the personalization of the effort level required (target heart rate) during rehabilitation. In this study the evolution of the comfortable and fast speed will be collected and compared with the stress test data, and other measured parameters (functional score of Quebec, muscle Tests Shirado and Sorensen).


Eligibility criteria: Inclusion Criteria:

* Female or male
* age between 18 and 70
* Non-specific low back pain - achieved rehabilitation program

Exclusion Criteria:

* inflammatory diseases
* cancer
* infectious diseases

Primary outcomes:
measure: COMFORTABLE WALKING SPEED (TEST OF 400M)
timeFrame: 4 weeks
Secondary outcomes:
measure: 200m fast walk test walking velocity
timeFrame: 4 weeks
measure: Quebec score
timeFrame: 4 weeks
measure: Shirado test
timeFrame: 4 weeks
measure: Sorensen test
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Dijon
country: France
facility: Rehabiltiation department CHU Dijon
Study officials:
References:
Clinical trial NCT06271863: Outcome of Conservative Management in Cases of Pre Mature Rupture of Membranes (PROM) Between 20 and 28 Weeks of Pregnancy in Sohag City Hospitals
Official title: Outcome of Conservative Management in Cases of Pre Mature Rupture of Membranes (PROM) Between 20 and 28 Weeks of Pregnancy in Sohag City Hospitals
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: PROM, Preterm (Pregnancy)
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2024-02-22
Enrollment: 100
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: pregnant woman 24 weeks to 28 weeks of pregnancy with PROM in sohag city hospitals

Brief summary: Prospective observational study


Eligibility criteria: Inclusion Criteria:

* pregnant woman 24 weeks to 28 weeks of pregnancy with PROM

Exclusion Criteria:

* gestational age other than the mentioned before Multiple pregnancy Cerclage Other causes of decreased AF

Primary outcomes:
measure: Conservation vs termination in cases of PROM 20 to 28 weeks of pregnancy
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Sohag university hospital
Study officials:
References:
Clinical trial NCT01106963: Anterior Knee Pain After Tibial Nailing
Official title: Nail Position Has an Influence on Anterior Knee Pain After Tibial Intramedullary Nailing
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Knee Pain
Keywords: knee
tibial fractures
pain
osteosynthesis
intramedullary nailing
Lead sponsor: University of Zagreb
Sponsor class: OTHER
First posted: 2010-04-20
Enrollment: 50
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population consists of primary care hospital trauma patients with tibial shaft fractures treated with intramedullary nailing.

Brief summary: Anterior knee pain (AKP) is a common complication following intramedullary (IM) nailing of a tibial shaft fracture. The purpose of this prospective study was to determine if there is an association between AKP and nail position. The investigators have analyzed postoperative outcome results and the possible relationship between AKP according to the visual-analog scale (VAS) scale, and nail position marked as a distance from the tip of the nail to the tibial plateau (NP) and tuberositas tibiae (NT), measured postoperatively on L-L knee X-rays.

Detailed description: The aim of this study was to determine the possible relationship between anterior knee pain (AKP) and nail position marked as a distance from tip of nail to tibial plateau (NP) and to the tuberositas tibiae (NT).

We evaluated postoperative outcome results of 50 patients in the last 3 years with healed fractures initially treated with intramedullary (IM) reamed nails with 2 or 3 interlocking screws on both parts of the nail and with the use of medial peritendinous incision for nail entry portal. Patients marked a point on the visual analog scale (VAS) that corresponded to the level of postoperative AKP felt. Two groups of patients were formed on the basis of AKP (pain level was neglected): groups A and B, with and without pain, respectively.

We found that the difference between the two groups concerning NP measurements was statistically significant, but not concerning NT measurements (P \< 0.05). Patients were classified by pain with high accuracy (98%) according to a classification tree.

We conclude that the symptoms of AKP did not appear if the tip of the nail position was more than 6.0 mm from the NP and more than 2.6 mm from the NT. However, for better evaluation of these results it will be necessary to examine more postoperative patients with AKP.

Eligibility criteria: Inclusion Criteria:

* tibial shaft fractures
* fracture treatment with intramedullary nailing with 2 or 3 interlocking screws on both ends of the nail

Exclusion Criteria:

* amputated legs

Primary outcomes:
measure: Anterior knee pain
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Zagreb
country: Croatia
facility: University of Zagreb School of Medicine, Department of Traumatology
Study officials:
affiliation: University of Zagreb School of Medicine
name: Nikica Darabos, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00584363: Pancreatic and Gastrointestinal Tumor Registry and Tissue Collection
Official title: Pancreatic and Gastrointestinal Tumor Registry and Tissue Collection (UAB/UMN SPORE in Pancreatic Cancer)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pancreatic Cancer
Lead sponsor: University of Alabama at Birmingham
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2008-01-02
Enrollment: 731
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults 19 years of age or older, pancreatic cancer patients at the University of Alabam at Birmingham.

Brief summary: The purpose of the study is to collect pancreatic tissue, blood and urine from adults to study pancreatic abnormalities.

Detailed description: The aim of the study is to standardize, collect and share pancreatic cancer related information, to be used for research purposes only by researchers from different participating institutions/centers.

Eligibility criteria: Inclusion Criteria:

* Person over 19 years of age, patient with a tissue-proven diagnosis of pancreatic cancer at the University of Alabama at Birmingham (UAB) University Hospital during the period, and cognitive ability to provide informed consent

Exclusion Criteria:

* Person not 19 or older and have not had a tissue-proven diagnosis of pancreatic cancer.

Primary outcomes:
measure: To diagnose Pancreatic Cancer
timeFrame: 5 years
Secondary outcomes:
measure: Preventing patient form being misdiagnosed
timeFrame: 5 years
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
Study officials:
affiliation: University of Alabama at Birmingham
name: Charles M Wilcox, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02263963: The Transversus Abdominis Plane Block: A Prospective Randomized Clinical Trial Using EXPAREL.
Official title: The Transversus Abdominis Plane Block: A Prospective Randomized Clinical Trial Using EXPAREL.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Postoperative Pain
Lead sponsor: Spectrum Health Hospitals
Sponsor class: OTHER
First posted: 2014-10-15
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to evaluate the effectiveness of EXPAREL in a transversus abdominis plane block by assessing the demand of postoperative narcotic, length of hospital stay and incidence of postoperative complications.


Eligibility criteria: Inclusion Criteria:

1. Patients over the age of 18 years w
2. Elective laparoscopic colorectal resection.

Exclusion Criteria:

1. Patients under 18 years.
2. Patients unable to provide informed consent
3. Patients undergoing emergency surgery.
4. Pregnant women
5. Severe liver or kidney disease (GFR 15-29 ml/min)

Primary outcomes:
measure: Postoperative Pain Score
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 4 days
Secondary outcomes:
measure: Postoperative Narcotic Use
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 4 days
Other outcomes:
measure: Postoperative Complications.
timeFrame: participants will be followed for the duration of hospital stay, and 30 days after discharge.
measure: Length of Hospital Stay.
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 4 days
Locations:
city: Grand Rapids
country: United States
facility: Spectrum Health
state: Michigan
Study officials:
References:
Clinical trial NCT03596463: Influence of Multidisciplinary Breast Tumor Board on Physician Decision
Official title: Influence of Multidisciplinary Breast Tutor Board on Physician Clinical Decision
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Breast Cancer
Breast Neoplasms
Surgery
Oncology
Lead sponsor: Okan University
Sponsor class: OTHER
First posted: 2018-07-23
Enrollment: 120
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 120 patients having breast cancer

Brief summary: In our study, the treatment plan for the case prior to the breast tumor counseling will be asked to physician and the treatment protocol observed by the primary physician will be observed after the decision of the tumor council.


Eligibility criteria: Inclusion Criteria:

Patients having primary breast cancer

Exclusion Criteria:

Patients having recurrent breast cancer -

Primary outcomes:
measure: Better survival
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: