Clinical trial NCT06729268: Fluid Responsiveness Tests in Critically Ill Patients During Admission to the Intensive Care Unit
Official title: Possibility of Applying Fluid Responsiveness Tests in Critically Ill Patients During Admission to the Intensive Care Unit - a Prospective Observational Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Shock Circulatory
Heart Failure
Hypovolemia
Lead sponsor: Uniwersytecki Szpital Kliniczny w Opolu
Sponsor class: OTHER
First posted: 2024-12-11
Enrollment: 389
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients admitted to the intensive care unit

Brief summary: The goal of this observational study is to investigate the prevalence of conditions allowing the performance fluid responsiveness tests in critically ill patients during admission to the intensive care unit.

Detailed description: Patients admitted to the intensive care unit are very often hemodynamically unstable. In these cases fluid responsiveness tests should be performed to assess whether the patient would benefit from the fluid administration.

However, fluid responsiveness tests have many limitations including lack of spontaneous breathing, necessity of invasive mechanical ventilation with tidal volume of \> 8 mL/kg ideal body weight, regular hearth rhythm, and lack of abdominal hypertension.

In the study, the investigators evaluated the prevalence of conditions enabling the performance fluid responsiveness tests in patients admitted to the intensive care unit. An assessment was performed within the six hours after admission to the intensive care unit. Evaluation was based on transthoracic echocardiography, clinical examination of the patients, and data derived from anamnesis.

The following fluid responsiveness tests were included into assessment: passive leg raising test, end-expiratory occlusion test, pulse pressure variation, stroke volume variation, velocity time integral variation in left ventricle output track, tidal volume challenge, inferior vena cava diameter variation, and superior vena cava diameter variation.

The aim of the study was to assess how many patients have the conditions allowing performance fluid responsiveness tests during admission to the intensive care unit.

Eligibility criteria: Inclusion Criteria:

1. Adult patients admitted to the intensive care unit

Exclusion Criteria:

1. Age under 18
2. The researcher unavailable in the intensive care unit
3. Patient assessment cannot be completed within the first six hours after admission to the ICU

Primary outcomes:
measure: To assess the prevalence of conditions allowing the performance fluid responsiveness tests during admission to the intensive care unit.
timeFrame: Six hours after admission to the intensive care unit
Secondary outcomes:
measure: To assess which fluid responsiveness test based on heart-lung interactions can be applied most often during admission to the intensive care unit
timeFrame: Six hours after admission to the intensive care unit
measure: To assess the percentage of patients in shock whom fluid responsiveness tests can be performed during admission to the intensive care unit
timeFrame: Six hours from the admission to the intensive care unit.
Other outcomes:
Locations:
city: Opole
country: Poland
facility: Department of Anesthesiology and Intensive Care, Uniwersytecki Szpital Kliniczny w Opolu
Study officials:
References: