louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06619535: Sepsis As a Cause of Death Among Elderly Cancer Patients
Official title: Sepsis As a Cause of Death Among Elderly Cancer Patients: an Updated SEER Database Analysis 2000-2021
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sepsis
Cancer
Keywords: sepsis
Cancer
mortality
SMR
SEER
Lead sponsor: Suez Canal University
Sponsor class: OTHER
First posted: 2024-10-01
Enrollment: 5239194
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: elderly cancer patients

Brief summary: The goal of this retrospective study is to explore the association between sepsis and morality among the elderly cancer patients. Data were extracted from the Surveillance, Epidemiology and End Results( SEER) database using SEER\*stat software. The study included patients aged 65 years or more who were diagnosed with cancer from 2000 to 2021. The extracted data included age, race, marital status, sex, stage, surgery, chemotherapy and radiotherapy. Multiple primary session was used to calculate the standardized Mortality ratio (SMR) as Observed/Expected with excess risk/10,000 and significance was achieved at 0.05.


Eligibility criteria: Inclusion Criteria:

* cancer patients
* age 65 year or more
* latency exclusion period of 0 months.

Exclusion Criteria:

- Death certificate only and autopsy only cases

Primary outcomes:
measure: SMR for sepsis as a cause of death among elderly cancer patients
timeFrame: from Jan, 2000 till Dec, 2021
Secondary outcomes:
Other outcomes:
Locations:
city: Ismailia
country: Egypt
facility: Suez Canal University
Study officials:
References:
Clinical trial NCT00717535: Studying Umbilical Cord Blood From African-American Donors
Official title: Investigation of the Total Nucleated Cell Yield of Cord Blood Units Collected From African-American Donors in Correlation With Gestational and Other Health Variables
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Health Status Unknown
Keywords: health status unknown
Lead sponsor: Barbara Ann Karmanos Cancer Institute
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2008-07-17
Enrollment: 0
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: African American cord blood donors

Brief summary: RATIONALE: Studying umbilical cord blood in the laboratory and gathering information about current and previous pregnancies from African-American umbilical cord blood donors may help doctors learn more about the umbilical cord blood of these donors.

PURPOSE: This clinical trial is looking at umbilical cord blood from African-American donors.

Detailed description: OBJECTIVES:

* To correlate the total nucleated cell yield of cord blood units from African-American cord blood donors with gestational history, maternal history, and delivery information.

OUTLINE: This is a multicenter study.

Donors complete questionnaires about their demographics, maternal history, gestational history, and delivery. Cord blood units (CBU) are collected in utero and transported to the Stem Cell Processing Laboratory where they are evaluated for CBU volume and cell count (i.e., total nucleated cell yield) and cryopreserved. The study results will then be used to devise future interventional strategies to improve the yield of nucleated cells of CBU.

Eligibility criteria: DISEASE CHARACTERISTICS:

* African-American participant in the National Marrow Donor Program cord blood collection protocol C-2844
* Recruited from the Labor and Delivery Suites of the Detroit Medical Center or its affiliated sites

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* Not specified

Primary outcomes:
measure: Correlation between total nucleated cell yield of cord blood units and gestational history, maternal history, and delivery information
timeFrame: Within a year
measure: Improvement in total nucleated cell yield of cord blood units from African-American donors
timeFrame: Within a year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Barbara Ann Karmanos Cancer Institute
name: Voravit Ratanatharathorn, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05731635: Plantar Pressure Values in Patients With Ankylosing Spondylitis
Official title: Plantar Pressure Values in Patients With Ankylosing Spondylitis and Their Relation With Clinical and Radiological Parameters
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Device is Used for Evalution (Event)
Lead sponsor: Amasya University
Sponsor class: OTHER
First posted: 2023-02-16
Enrollment: 75
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Seventy-five adult patients who applied to Celal Bayar University outpatient clinics and were diagnosed with AS according to the modified New York criteria were included in the study.

Brief summary: this study was discovered that clinical and radiological characteristics were related to plantar pressure assessments in patients with AS.

Detailed description: Determine the correlation between the plantar pressure readings of AS patients and the clinical and radiological measures utilized in the monitoring of the condition.

Method: This study covered 75 participants. The quality of life was measured using ASQoL, BASMI, BASFI, and BASDAI, and demographic information was also recorded. The pedobarographic evaluations included the recording of static and dynamic plantar pressures

Eligibility criteria: Inclusion Criteria: patients diagnosed with AS -

Exclusion Criteria: Patients with cognitive dysfunction, vision loss that would prevent walking on the pedobarography platform, history of surgery and neurological deficit in the lower extremity, and patients who could not walk independently

-

Primary outcomes:
measure: Pedobarographic Measurements
timeFrame: at begining
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00508235: Quality of Friendships in Children With Neurofibromatosis
Official title: Quality of Friendships in Children With Neurofibromatosis: Relationship to Disease Severity
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neurofibromatosis
Keywords: Neurofibromatosis
Quality of Friendships
Disease Severity
Questionnaire
NF-1
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
First posted: 2007-07-27
Enrollment: 61
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study participants with Neurofibromatosis, type 1 (NF-1) between the ages of 8 and 18 years old.

Brief summary: The aim of this study is to determine if children with a higher disease severity have lower quality friendships than children who are less severely affected and children who are unaffected. Researchers will test the hypothesis that the quality of friendships is inversely related to their disease severity.

Specific Aims:

1. To use the FQQ to determine if the quality of friendships in children with NF1 is lower than the quality of friendships in unaffected children.
2. To use a disease severity scale and the FQQ to determine if children who are less severely affected have higher friendship qualities than children who are more severely affected.

Detailed description: You (your) child will be asked to complete a short questionnaire (40 questions) about their relationship with their best friend. Doctors will review your (child's) medical chart to find out how severe the disease is, so that this may be compared to the answers you have (your child has) given on the friendship questionnaire.

This is an Investigational Study. About 90-100 children and adolescents with NF-1 will be asked to take part in this study. All will be enrolled at M.D. Anderson.

Eligibility criteria: Inclusion Criteria:

1) Patients with a clinical diagnosis of neurofibromatosis, type 1 (NF-1) who are between the ages of 8 and 18 years will be eligible. Patients must be English or Spanish speaking (test instrument will be translated into Spanish), and be able to read.

Exclusion Criteria:

Primary outcomes:
measure: Disease severity scale and Friendship Quality Questionnaire (FQQ)
timeFrame: Questionnaire completion by patient and chart review by doctor for disease severity scoring.
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: U.T.M.D. Anderson Cancer Center
state: Texas
Study officials:
affiliation: M.D. Anderson Cancer Center
name: Bartlett D. Moore, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02368535: Improving Teamwork in an Academic, Tertiary Care Labor and Delivery Unit
Official title: A Decade of Safon Rounds: Interdisciplinary Daily Rounding as a Method of Improving Teamwork in an Academic, Tertiary Care Labor and Delivery Unit
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Interdisciplinary Communication
Keywords: teamwork
Lead sponsor: Brigham and Women's Hospital
Sponsor class: OTHER
First posted: 2015-02-23
Enrollment: 234
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Staff working at Brigham and Women's Hospital Labor and Delivery Suite

Brief summary: The investigators wanted to determine if the establishment of interdisciplinary rounds has made meaningful changes in the perceptions of teamwork and communication.

The purpose of this study is to determine if the establishment of interdisciplinary daily rounding has improved teamwork in an academic, tertiary care labor and delivery unit.

Detailed description: Failures in teamwork and communication are among the leading cases of sentinel and adverse obstetric events. Multidisciplinary approaches and communication could improve patients outcomes. In 2003, leaders from the department of obstetrics, anesthesia and nursing decided to institute interdisciplinary rounds as a method of improving team communication. Obstetricians, Anesthesiologists, Nurses, Perinatologists, Administrative Assistants, Consultants, and Neonatologists participate in the rounds. The investigators wanted to determine if the establishment of interdisciplinary rounds has made meaningful changes in the perceptions of teamwork and communication.

The purpose of this study is to determine if the establishment of interdisciplinary daily rounding has improved teamwork in an academic, tertiary care labor and delivery unit.

Eligibility criteria: Inclusion Criteria:

* Working at L\&D at Brigham and Women's and participating in daily rounds

Exclusion Criteria:

* subject's refusal to participate

Primary outcomes:
measure: Perception of Teamwork Elements Present in Interdisciplinary Rounds - Total Response Scores
timeFrame: Individual Participation-10 min; Study Completion within 1 Year
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
Study officials:
affiliation: Brigham and Women's Hospital
name: Lawrence Tsen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01960335: Whey Protein Intake With and Without Exercise on Visceral Fat: The P+RISE Study
Official title: Whey Protein With and Without Exercise Training Enhances Total and Regional Body Composition, Insulin, Leptin, and Blood Pressure in Overweight and Obese Adults - The P+RISE Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Overweight
Keywords: whey protein intake
obesity
visceral fat
resistance exercise training
sprint interval training
endurance exercise training
yoga training
healthy eating
healthy lifestyle strategies
leptin
hunger
Lead sponsor: Skidmore College
Sponsor class: OTHER
First posted: 2013-10-10
Enrollment: 79
Sex: ALL
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Dietary manipulation is proving to be an effective lifestyle strategy to combat the obesity epidemic. Increased dietary protein is one effective strategy. For example, increased whey protein ingestion with and without exercise training is associated with enhanced weight loss, body composition and subjective hunger in overweight and obese individuals. Our findings suggest that the effects of whey protein ingestion occur independent of a calorie-restricted diet and to a greater extent in individuals following a combined exercise program of resistance exercise, sprint intervals, stretching/yoga/pilates, and aerobic exercise training compared to standard resistance training.

Detailed description: This study was a 16 week whey protein and exercise training intervention in middle aged overweight/obese adults. Subjects were randomized into 3 groups: Whey protein only consumed as 20 grams per serving three times per day (total 60 grams per day) (WP); Whey protein and resistance exercise training (WP-RT); and Whey protein and combined exercise training (P+RISE). All outcomes, including the primary outcome of visceral fat was measured at baseline (week 0) and post-intervention (week 17) in all study subjects.

Eligibility criteria: Inclusion Criteria:

* healthy, overweight or obese, inactive

Exclusion Criteria:

* smoker, exercise-trained, recent weight loss, heavy caffeine-consumer

Primary outcomes:
measure: change in visceral fat
timeFrame: baseline and 17 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Saratoga Springs
country: United States
facility: Health & Exercise Sciences Department, Human Nutrition and Metabolism Laboratory, Skidmore College
state: New York
Study officials:
affiliation: Skidmore College
name: Paul J Arciero, Doctorate
role: PRINCIPAL_INVESTIGATOR
References:
citation: Baer DJ, Stote KS, Paul DR, Harris GK, Rumpler WV, Clevidence BA. Whey protein but not soy protein supplementation alters body weight and composition in free-living overweight and obese adults. J Nutr. 2011 Aug;141(8):1489-94. doi: 10.3945/jn.111.139840. Epub 2011 Jun 15.
Clinical trial NCT04808635: The Predictors of Depression and Burnout Among Surgical Residents: A Cross-sectional Study From Kuwait
Official title: The Predictors of Depression and Burnout Among Surgical Residents: A Cross-sectional Study From Kuwait
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Burnout
Lead sponsor: Ministry of Health, Kuwait
Sponsor class: OTHER_GOV
First posted: 2021-03-22
Enrollment: 80
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: surgical residents across 4 specialties.

Brief summary: To assess the prevalence and risk factors for depression and burnout among residents across surgical specialties in Kuwait.

Detailed description: This is a questionnaire based cross-sectional study conducted in Kuwait from jan 2021- February 2021 An online questionnaire was sent to the residents enrolled to the surgical residency programs in Kuwait. Residency training in Kuwait provides programs in both medical and surgical specialties. Specialties included in our cohort were: general surgery, orthopedic surgery, urology, neurosurgery, Obstetrics and Gynecology and otolaryngology.

The email sent to our participants included an invitation letter detailing the reason behind the questionnaire and that it is confidential and anonymous. Consent was obtained from participants.

Variables:

Variables collected included; age, gender, marital status, smoking history, exercise, specialty, year of training, on-call frequency, assessment of burnout and assessment of depression symptoms.

Eligibility criteria: Inclusion Criteria:

- residents enrolled in surgical training in Kuwait. Across all surgical specialties From R1-R5

Exclusion Criteria:

Recently accepted candidates that have not yet started residency.

Primary outcomes:
measure: Symptoms of depression were assessed using the 9-item Patient Health Questionnaire (PHQ-9) score
timeFrame: 1 month
measure: Burnout symptoms were assessed using 9-item form of the Maslach Burnout Inventory - Human Services Survey (aMBI-HSS)
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Kuwait
country: Kuwait
facility: Mubarak al Kabeer hospital
state: Outside U.S./Canada
Study officials:
References:
Clinical trial NCT01796158: Pilot Test of Computerized MET to Reduce Adolescent Alcohol Use
Official title: Pilot Test of Computerized MET Intervention to Reduce Adolescent Alcohol Use
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Alcohol Abuse
Keywords: adolescents
alcohol abuse
drug abuse
substance use
Lead sponsor: Boston Children's Hospital
Sponsor class: OTHER
First posted: 2013-02-21
Enrollment: 0
Sex: ALL
Minimum age (years): 12
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this project is to conduct a pilot study evaluating feasibility, acceptability, and estimating the effect size of a new computerized Motivational Enhancement Therapy (cMET) intervention for alcohol-involved adolescent primary care patients.

Detailed description: The goal of this project is to conduct a pilot study evaluating feasibility, acceptability, and estimating the effect size of a new computerized Motivational Enhancement Therapy (cMET) intervention for alcohol-involved adolescent primary care patients. The investigators hypothesize that 1) cMET, when added to Computerized Alcohol Screening and Brief Intervention (cASBI), (cASBI+cMET) will be feasible and acceptable when used in primary care; and 2) 12- to 18-yr old patients receiving cASBI+cMET will have lower rates of any alcohol use, days of alcohol use, drinks per drinking day, and days of heavy episodic drinking, than cASBI alone.

Eligibility criteria: Inclusion Criteria:

* any alcohol use days in the past 90 days
* have an email address and internet access at home, school, or library

Exclusion Criteria:

* unable to read or understand English
* living away at college at the time of the recruitment visit
* not available for computer/telephone follow-ups
* judged by the provider to be medically or emotionally unstable at time of visit

Primary outcomes:
measure: cMET completion
timeFrame: Baseline
Secondary outcomes:
measure: cMET satisfaction
timeFrame: 9 months
Other outcomes:
measure: Alcohol use
timeFrame: 9 months
Locations:
city: Boston
country: United States
facility: Boston Children's Hospital
state: Massachusetts
Study officials:
References:
Clinical trial NCT00802958: Randomized Study to Compare the Bioavailability of Two Halobetasol Propionate 0.05% Topical Ointments
Official title: Bioequivalence of Two Halobetasol Propionate 0.05% Topical Ointments
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: Bioequivalence
Halobetasol Propionate
Lead sponsor: Padagis LLC
Sponsor class: INDUSTRY
First posted: 2008-12-05
Enrollment: 76
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy Community Volunteers

Brief summary: The purpose of this study was to compare the relative vasoconstrictive effects of test and reference Halobetasol Propionate 0.05% Ointment in healthy, female subjects.


Eligibility criteria: Inclusion Criteria:

* Non-tobacco using female subjects, 18 to 50 years of age
* Demonstrated blanching response to Reference Drug
* Weight within +/- 20% from normal for height and weight for body frame
* Good health as determined by lack of clinically significant abnormalities in medical history and clinical assessment, as judged by the Investigator
* Signed and dated informed consent form which meets all criteria of current FDA regulations

Exclusion Criteria:

* History of allergy to systemic or topical corticosteroids
* Presence of any skin condition or coloration that would interfere with the placement of test sites or the response or assessment of skin blanching
* Presence of medical condition requiring regular treatment with prescription drugs
* Drug or alcohol addiction requiring treatment in the past 12 months prior to dosing
* Use of any tobacco products in the 30 days prior to study dosing
* Use of any dermatological drug therapy on the flexor surface of the forearms within 30 days of dosing
* Receipt of any drugs as part of a research study within 30 days prior to study dosing
* Pregnant or lactating

Primary outcomes:
measure: Vasoconstriction will be measured by the degree of skin blanching observed after treatment removal using a ChromaMeter
timeFrame: Over the course of a day
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: