Clinical trial NCT05355324: Risk Factor for Readmission and Death of Lower Respiratory Infections in Older Adults
Official title: Anemia is a Risk Factor for Readmission and Death of Lower Respiratory Infections in Older Adults
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lower Respiratory Infection
Anemia
Readmission
Death
Lead sponsor: Beijing Tongren Hospital
Sponsor class: OTHER
First posted: 2022-05-02
Enrollment: 215
Sex: ALL
Minimum age (years): 80
Maximum age (years): 100
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Elderly patients (age: ≥ 80 years), hospitalized (from 31 March 2016 to 27 December 2019) at the Department of Geriatrics of a hospital in Beijing, China, and were with lower respiratory tract infection(LRTI) (including pneumonia and acute exacerbation of chronic obstructive pulmonary disease) were included. 215 patients (age: \>/=80 years) who were hospitalized due to LRTI and discharged after being cured were studied. Of these 215 patients, 149 belonged to the anemia group, and 66 belonged to the non-anemia group. The mean age of the cohort at the time of inclusion was 88.73 (SD 4.765) years, and 77.2% of the patients were men.

Brief summary: Lower respiratory tract infection(LRTI) is a prevalent disease that threatens the health of older people worldwide. Anemia is also a common disorder in the elderly, and its prevalence increases significantly with age. Most factors that contribute to the development of anemia are improvable. Therefore, we investigated whether anemia was a risk factor for LRTI-caused readmission and death in the elderly occurring within 1 year of discharge from the hospital.

Detailed description: Objectives: To investigate the effect of anemia on readmission and deaths in the older adults following lower respiratory tract infection (LRTI)-caused hospitalization.

Design: A retrospective cohort study. Setting and Participants: Older patients (age: ≥ 80 years) hospitalized at the Department of Geriatrics, from March 2016 to December 2019 to undergo treatment for LRTIs were included.

Methods: The patients were divided into two groups (anemia and non-anemia) based on the level of hemoglobin. They were kept under observation till the occurrence of mortality event or 1 year after discharge. The primary follow-up outcome was LRTI-caused readmission and/or death.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 80 years
* lower respiratory tract infection

Exclusion Criteria:

* Died at the time of first admission
* Active malignancy
* Tuberculosis
* Anemia caused by gastrointestinal bleeding of unknown origin
* Achalasia of the cardia
* Could not be followed up after discharge
* Data were missing

Primary outcomes:
measure: Number of Patients with Readmission and/ or Death Caused by Lower Respiratory Tract Infection(LRTI) within One Year of Discharge
timeFrame: March 2016 to 27 December 2019
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: He Y, Chen Y, Cao K, Zheng H. Effect of Anemia on Readmission and Death in Octogenarian Patients with Lower Respiratory Tract Infections: A Retrospective Cohort Study. Int J Clin Pract. 2022 Oct 27;2022:4566936. doi: 10.1155/2022/4566936. eCollection 2022.