louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03235622: Women Health Cohort for Breast, Bone and Coronary Artery Disease
Official title: Women Health Cohort for Breast, Bone and Coronary Artery Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2017-08-01
Enrollment: 2100
Sex: FEMALE
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: * The number of women who met inclusion criteria was 2113.
* 13 women were excluded due to history of coronary revascularization (n=1) and breast surgery or intervention (n=12).
* Finally, 2100 women were enrolled to the BBC cohort.

Brief summary: A single center cohort which enrolled women who performed mammography, bone densitometry (DEXA), and coronary CT angiography in Seoul National University Bundang Hospital from March 2011 to February 2013.

Detailed description: To evaluate whether bone mineral density and breast arterial calcification can predict coronary artery disease in women older than 40 years

Eligibility criteria: Inclusion Criteria:

* Women (≥ 40 years) who performed mammography, bone DEXA, and coronary CT angiography at health promotion center of Seoul National University Bundang Hospital.

Exclusion Criteria:

* Women who have history of breast surgery or intervention
* Women who have history of myocardial infarction or revascularization
* Too poor image quality of coronary CT angiography for interpretation
* Renal dysfunction with serum creatinine ≥ 1.4mg/dL

Primary outcomes:
measure: Presence of coronary plaque
timeFrame: 5 years
Secondary outcomes:
measure: Characteristics of coronary plaque
timeFrame: 5 years
measure: Major adverse cardiovascular events
timeFrame: 5 years
Other outcomes:
Locations:
Study officials:
affiliation: Seoul National University Bundang Hospital
name: Jung-Won Suh, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yoon YE, Kim KM, Han JS, Kang SH, Chun EJ, Ahn S, Kim SM, Choi SI, Yun B, Suh JW. Prediction of Subclinical Coronary Artery Disease With Breast Arterial Calcification and Low Bone Mass in Asymptomatic Women: Registry for the Women Health Cohort for the BBC Study. JACC Cardiovasc Imaging. 2019 Jul;12(7 Pt 1):1202-1211. doi: 10.1016/j.jcmg.2018.07.004. Epub 2018 Aug 15.
Clinical trial NCT01219439: Evaluation of Discarded Laboratory Pathological Specimens and Media
Official title: Laboratory Evaluation of IVF Discarded Pathological Specimens and Media for Optimization of Techniques for Assisted Reproduction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Non-viable Oocytes
Extra Spermatozoa
Seminal Fluid
Granulosa Cells
Serum
Follicular Fluid
Conditioned IVF Media
Keywords: discarded pathological specimens
discarded media
IVF
Lead sponsor: Reproductive Medicine Associates of New Jersey
Sponsor class: OTHER
First posted: 2010-10-13
Enrollment: 10000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients undergoing infertility treatment.

Brief summary: The researchers propose to investigate the causes, incidence, and time-related events of chromosomal and physiologic abnormalities as they relate to patient diagnosis, fertility drugs utilized, and in vitro laboratory culture conditions.

Detailed description: We propose to identify a group of parameters that have significant predictive value for assisted reproductive technology outcomes. We seek to test, standardize and implement better methods for the freezing of oocytes and sperm prior to these techniques being used in the clinical setting. We seek to develop new methods to optimize the determination of genes and chromosomes in gametes. We hope to develop new cell surgery or micromanipulation techniques (e.g. use of cell drills and lasers in order to enhance the efficiency of procedures such as ICSI, assisted hatching, biopsy) as well as other manipulations. We will test the safety and efficiency of micro fluidics and automation in the Embryology lab. This has the potential to reduce cost, human errors, temperature and physical changes. We hope to develop new methods and media and media supplements normally found in the reproductive tract that allow for higher survival of gametes in vitro. We will also test the proficiency of laboratory staff members on techniques and/or procedures performed in the in-vitro fertilization laboratory. We will perform Quality Control to review how changes in temperature and setting can effect specimens

Eligibility criteria: Inclusion Criteria:

none

Exclusion Criteria:

none

Primary outcomes:
measure: Methods for the freezing of ooyctes and sperm
timeFrame: duration of study
Secondary outcomes:
measure: New methods of gene and chromosome analysis
timeFrame: duration of study
Other outcomes:
Locations:
city: Basking Ridge
country: United States
facility: Reproductive Medicine Assoicates of New Jersey
state: New Jersey
Study officials:
affiliation: Reproductive Medicine Associates of New Jersey
name: Richard T Scott, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05974839: Effect of Ocrelizumab on Cortical Lesion Accumulation in Patients With PPMS (ORATORIO-Cortical)
Official title: Effect of Ocrelizumab on Cortical Lesion Accumulation in Patients With Primary-progressive Multiple Sclerosis Participating in the ORATORIO: a Post-hoc Analysis of a Double-blind, Randomized, Phase 3, Placebo-controlled Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Primary Progressive Multiple Sclerosis
Lead sponsor: State University of New York at Buffalo
Sponsor class: OTHER
Collaborators: name: Genentech, Inc.
First posted: 2023-08-03
Enrollment: 732
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Primary Progressive Multiple Sclerosis

Brief summary: The goal of this non-interventional, observational study is to determine whether cortical pathology can be slowed down by use of ocrelizumab.

Detailed description: To study the effect of ocrelizumab on cortical lesion accumulation in patients with primary-progressive multiple sclerosis participating in the ORATORIO: a post-hoc analysis of a double-blind, randomized, phase 3, placebo-controlled study.

Eligibility criteria: Inclusion Criteria:

* Patient participating in the ORATORIO study
* MRI scans available at baseline
* Presence of T2-weighted image (WI) (FLAIR, T2/PD), and 2D/3D T1-WI at baseline

Exclusion Criteria:

- None

Primary outcomes:
measure: Cortical lesion number accumulation
timeFrame: 5 years
Secondary outcomes:
measure: Cortical lesion number accumulation and disability.
timeFrame: 5 years
Other outcomes:
Locations:
city: Buffalo
country: United States
facility: Buffalo Neuroimaging Analysis Center
state: New York
Study officials:
References:
Clinical trial NCT04673539: Spanish Version of the Brief-BESTest in Stroke Patients
Official title: Adaptation and Validation of the Spanish Version of the Brief-BESTest in Stroke Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stroke
Keywords: Stroke
Validation Study
Postural Balance
Lead sponsor: University of Salamanca
Sponsor class: OTHER
First posted: 2020-12-17
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Stroke patients

Brief summary: The aim of this study is to adapt and validate the Spanish version of the Brief-BESTest in stroke patients

Detailed description: Balance disorder is a major risk factor for falls. The population that has suffered a cerebrovascular accident (CVA) or stroke has balance disorders. Over the last few years the assessment of balance has taken on special importance, carrying out the development, adaptation and validation of various tools that assess it.

The Brief-BESTest has 6 items, it has demonstrated comparable reliability to the Mini-BESTest and potentially superior sensitivity. This version represents all dimensions based on the original BESTest theory.

The purpose is to adapt and validate the Spanish version of the Brief-BESTest in stroke patients in order to have a brief tool, appropriate to the clinical environment and to the characteristics and limitations of these patients.

Eligibility criteria: Inclusion Criteria:

* Older than 18 years old
* Diagnosis of stroke

Exclusion Criteria:

* Cognitive impairment
* Physical disability that prevents them from completing the assessment
* No cooperation and communication problems

Primary outcomes:
measure: BESTest
timeFrame: Baseline
measure: Mini-BESTest
timeFrame: Baseline
measure: Berg Balance Test
timeFrame: Baseline
measure: Time Up and Go Test
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Salamanca
country: Spain
facility: Universidad de Salamanca
Study officials:
References:
Clinical trial NCT00275639: The Effects of Angiotensin II Receptor Blockade on Kidney Function and Scarring After Liver Transplant
Official title: A Randomized, Double-blinded, Placebo-controlled Study of Angiotensin II Receptor Blockade to Prevent Renal Dysfunction Following Liver Transplantation.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Liver Transplant Recipients
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2006-01-12
Enrollment: 62
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This research study is being done to study the effects, both good and bad, of calcineurin inhibitors and the drug Cozaar (losartan), on kidney function and kidney scarring following a liver transplant.

Detailed description: This study is a double-blinded, placebo controlled trial to help determine the pathogenesis of chronic renal dysfunction in patients undergoing liver transplantation. It will examine the renal function and renal morphology in patients on calcineurin inhibitors and the effects of Cozaar (losartan) following liver transplantation. Participants will have blood, urine and iothalamate clearance test, to look at kidney function prior to transplant. At the time of transplant, kidney biopsies will be performed in the operating room under anesthesia. Participants will be in the study for one year. At three weeks following liver transplant, participants will be randomly assigned to receive either a placebo (inactive drug) or the study drug (losartan). The participant will need to continue to return to the clinic at the normal scheduled intervals. During these times blood and urine tests will be done. A kidney biopsy will be performed at the yearly exam and study pills will be stopped. The researchers will continue to follow participant's creatine measurements for the next 10 years.

Eligibility criteria: Participants who will be undergoing a liver transplant and are between the ages of 18 to 70 years of age.

Primary outcomes:
measure: Development of renal dysfunction (measured by iothalamate clearance).
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: K.V. Narayanan Menon, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03528239: The Use of Hospital and Emergency Department of Refugee Patients
Official title: The Use of Hospital Outpatient Clinics and Emergency Department by Refugee Patients in Turkey
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Refugees
Health Care
Outpatients
Emergency Departments
Lead sponsor: Nevsehir Public Hospital
Sponsor class: OTHER_GOV
First posted: 2018-05-17
Enrollment: 10000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Refugee patients are registered in the hospital system in a different way than that of others. We will use these datas as recorded refugees. And also, we will use the number of other visits to calculate the incidence of visits of refugees.

Brief summary: After Middle Eastern crisis, millions people were forced to migrate to European countries and especially neighboring countries. In Turkey, cities which are closed to east of border, face to cope more refugees' health care than those of other cities. The incidence of admission of hospital outpatient clinics and emergency department by refugee patients is not known clearly in our city, Nevsehir. In this study, we wanted to investigate use of health care among these patients in Nevsehir in Turkey.


Eligibility criteria: Inclusion Criteria:

All patients who visited an outpatient clinic and emergency department.

Exclusion Criteria:

Patients who have missing records.

Primary outcomes:
measure: The incidence of outpatient clinics and emergency department use by refugee patients
timeFrame: 2014-2017
Secondary outcomes:
Other outcomes:
Locations:
city: Nevsehir
country: Turkey
facility: Nevsehir State Hospital
Study officials:
References:
Clinical trial NCT06428539: T Regulatory Cells IN LUPUS NEPHRITIS
Official title: T Regulatory Cells in Lupus Nephritis
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Lupus Nephritis
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-05-24
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: patients with lupus nephritis, both currently active or in remission, divided in Group 1: active lupus nephritis, Group 2: lupus nephritis in remission. Besides including normal Group 3: healthy volunteers

Brief summary: * To study the role FoxP3-positive T regulatory cells in the pathogenesis of Lupus Nephritis, and determine the factors associated with levels of T regs .
* To compare the functional capacity of T regs in LN and in normal individuals.

Detailed description: Lupus Nephritis (LN) encompasses a group of glomerulonephrites, that occur in association with systemic lupus erythematosus (SLE). The mainstream theory that it is an immune disease resulting from loss of immune tolerance against body cells. The regulatory T cells (T regs ) are a subpopulation of immune cells that maintain tolerance to self-antigens and suppress autoimmune diseases. The main marker of Tregs is FoxP3 (forkhead box protein 3) positivity. Moreover, It has been suggested that functional capacity of Tregs is also compromised in autoimmune diseases. Studying the role of T regs in LN is a promising field that can help tailor current immune therapy and develop new treatment strategies.

Eligibility criteria: Inclusion Criteria:

adults both genders clinical diagnosis of lupus nephritis

Exclusion Criteria:

patients diagnosed with other renal pathologies, e.g. diabetic kidney disease

Primary outcomes:
measure: FoxP3 between groups
timeFrame: baseline
measure: Association of FoxP3 and activity index
timeFrame: baseline
measure: Tregs in normal and lupus participants
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Doglio M, Alexander T, Del Papa N, Snowden JA, Greco R; Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT). New insights in systemic lupus erythematosus: From regulatory T cells to CAR-T-cell strategies. J Allergy Clin Immunol. 2022 Dec;150(6):1289-1301. doi: 10.1016/j.jaci.2022.08.003. Epub 2022 Sep 20.
Clinical trial NCT05969639: Improving Dietary Habit and Weight Loss in Young Adults With Overweight and Obesity: The Healthy Eating for Young Adults (HEYA) Study
Official title: Improving Dietary Habit and Weight Loss in Young Adults With Overweight and Obesity: The Healthy Eating for Young Adults (HEYA) Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Obesity
Lead sponsor: National University Health System, Singapore
Sponsor class: OTHER
First posted: 2023-08-01
Enrollment: 150
Sex: ALL
Minimum age (years): 21
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to examining the effectiveness of a psychoeducational program (Healthy Eating in Young Adults; HEYA) on improving the dietary habits and body composition (e.g. weight and percentage fat mass) in young adults in Singapore.


Eligibility criteria: Inclusion Criteria:

1. have a body mass index (BMI) ≥23kg/m2; and
2. are between the ages of 21 and 35 years old; and
3. can understand and read the English language; and
4. use a smartphone that can download apps; and
5. willing to travel to the National University Singapore.

Exclusion Criteria:

1. Pregnant or lactating; and
2. Participating in a structured weight loss program; and
3. Planning or receiving pharmacotherapy or bariatric surgery within the next 6 months; and
4. Has existing diagnosed mental disorder besides eating disorders.

Primary outcomes:
measure: weight
timeFrame: 0,12,24
Secondary outcomes:
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: National University of Singapore
Study officials:
References:
Clinical trial NCT05400239: SOTO: Treatment Sensitivity of Organoids to Predict Treatment Outcome
Official title: SOTO Study: Prospective Study to Correlate the Treatment Sensitivity of Patient-derived Organoids With Clinical Outcomes in Head and Neck Squamous Cell Carcinoma (HNSCC) Patients
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Head and Neck Cancer
Lead sponsor: Guy's and St Thomas' NHS Foundation Trust
Sponsor class: OTHER
First posted: 2022-06-01
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This is a prospective study with a one-year pilot study aiming to recruit 20 patients, which is the realistic target for year 1. The results from year 1 will be used to estimate the sample size for future prospective observation study

Brief summary: In this study, we aim to assess whether Patient Derived Organoids can be used to predict treatment sensitivity in HNSCC patients.

Detailed description: This is a prospective observation study to generate patient-derived organoids from patients' samples to assess treatment response and to correlate with patients' treatment outcomes and to collect preliminary data on the ability of PDOs to predict patients' treatment response and whether their radiosensitivity and chemosensitivity can be correlated with their survival outcome.

Eligibility criteria: Inclusion Criteria:

* Patients with head and neck squamous cell carcinoma (including oral cavity, oropharynx, paranasal sinuses, hypopharynx or larynx) undergoing curative treatment (primary surgery or radiotherapy) or presenting with recurrent or metastatic cancers
* Age \> 18 years old

Exclusion Criteria:

* Patients unable to give informed consent e.g. mental disability or vulnerable adults

Primary outcomes:
measure: Successful Organoids
timeFrame: 1 Year
Secondary outcomes:
measure: Sensitivity
timeFrame: 1 Year
measure: Treatment Outcome
timeFrame: 1 Year
Other outcomes:
measure: Treatment Sensitivities
timeFrame: 1 Year
measure: Patients Features
timeFrame: 1 Year
measure: PDOs Sensitivities
timeFrame: 1 Year
measure: Translational Research
timeFrame: 1 Year
Locations:
city: London
country: United Kingdom
facility: Guys Hospital
Study officials:
References:
Clinical trial NCT06745739: Life Skills Training Workplace Prevention Program
Official title: Life Skills Training Workplace Prevention Program
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Job Satisfaction
Work Performance
Health Care Utilization
Depression Symptoms
Stress
Lead sponsor: National Health Promotion Associates, Inc.
Sponsor class: INDUSTRY
First posted: 2024-12-20
Enrollment: 1313
Sex: ALL
Minimum age (years): 16
Maximum age (years): 24
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: A workplace health promotion intervention for youth age 16-24

Detailed description: A workplace health promotion intervention for youth age 16-24, adapted from the school-based Life Skills Training program. The program teaches participants the skills necessary to be productive in work and personal settings while also promoting healthy behaviors and preventing or reducing health risk behaviors. Program content focuses on goal-setting and problem-solving skills, stress and anger management skills, effective communication and conflict management skills, time and financial management, substance use risk reduction, and how to contribute to a healthy, safe, and drug-free workplace.

Eligibility criteria: Inclusion Criteria:

* employed at participating store

Exclusion Criteria:

-

Primary outcomes:
measure: job satisfaction
timeFrame: month
measure: work performance
timeFrame: month
measure: health care utilization
timeFrame: month
measure: symptoms of depression
timeFrame: month
measure: stress
timeFrame: month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05751239: Motives for Desiring Children in Different Sexual-romantic Orientations
Official title: Motives for Desiring Children in Different Sexual-romantic Orientations: A Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Family Characteristics
Sexual Orientation
Keywords: Romantic orientation
Queer
Parenting
Lead sponsor: Insel Gruppe AG, University Hospital Bern
Sponsor class: OTHER
First posted: 2023-03-02
Enrollment: 837
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: LGBT+ organisations and groups in Switzerland and social media were contacted for the participants' recruitment.

Brief summary: The goal of this cross-sectional study is to compare the motives for the desire to have children in different sexual-romantic orientation. The main question\[s\] it aims to answer are:

* Do all orientations have the same motives for the desire to have children?
* What are the preferred methods for having a child for the different orientations

Participants will answer an online questionaire .

Researchers will compare the different orientations to see if there are differences.


Eligibility criteria: Inclusion Criteria:

* All participants regardless of sex, gender or age

Exclusion Criteria:

* Incomplete questionnaire
* Under 18 years
* Caring for a child in a social, economic or educational way (self-report)

Primary outcomes:
measure: Possible difference in the motive to have a child between different orientations.
timeFrame: At baseline in July/August 2018
Secondary outcomes:
measure: Preferred way to have a child of the different orientations
timeFrame: At baseline in July/August 2018
Other outcomes:
Locations:
city: Bern
country: Switzerland
facility: Department of Obstetrics and Gynecology, lnselspital, Bern University Hospital, University of Bern
Study officials:
affiliation: Department of Obstetrics and Gynecology, lnselspital, Bern University Hospital, University of Bern
name: Petra Stute, Dr. med.
role: STUDY_CHAIR
References: