louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05627765: An Integrated Smoking Cessation and Alcohol Intervention for Young People
Official title: An Integrated Smoking Cessation and Alcohol Intervention Among Hong Kong Chinese Young People: A Feasibility Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Smoking Cessation
Alcohol Drinking
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
First posted: 2022-11-28
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The study will be a three-arm randomized controlled trial in a convenience sample of 150 smokers aged 18-25 years with a drinking habit who will be recruited from smoking hotspots in Mong Kok. Participants will be randomized into a standard treatment (ST), II, or control arm. Participants in the ST arm will receive a brief smoking cessation intervention based on the Asking about tobacco use, Advising smokers to quit, Assessing their willingness to quit, Assisting in quitting, and Arranging for follow-up and Relevance, Risks, Rewards, Roadblocks and Repetition models. Participants in the II arm will receive brief advice on alcohol use based on the FRAMES model in addition to the brief smoking cessation intervention. Booster interventions will be provided to both ST and II arms at 1-week, 1-month, 3-month, and 6-month follow-up. Participants in the control arm will receive leaflets on smoking cessation and alcohol abstinence. Data collection will be done at baseline and at 1-week, 1-month, 3-month, and 6-month follow-ups. Self-reported quitters at 6-month follow-up will be invited for biochemical validation.


Eligibility criteria: Inclusion Criteria:

* smoked at least one cigarette in the past 30 days
* have consumed at least one cup of alcohol (10 ounces of beer, 4 ounces of wine, or 1 ounce of liquor) in the past 30 days
* speak Cantonese.

Exclusion Criteria:

* have a compromised mental status and/or communication problems
* participating in other smoking cessation interventions

Primary outcomes:
measure: screening rate
timeFrame: 24 months
measure: eligibility rate
timeFrame: 24 months
measure: consent rate
timeFrame: 24 months
measure: randomization rate
timeFrame: 24 months
measure: attendance rate
timeFrame: 24 months
measure: adherence to intervention
timeFrame: 24 months
measure: retention rate
timeFrame: 24 months
measure: completion rate
timeFrame: 24 months
measure: missing data
timeFrame: 24 months
measure: adverse events
timeFrame: 24 months
Secondary outcomes:
measure: self-reported quit rate
timeFrame: 6 month
measure: biochemically validated quit rate
timeFrame: 6 month
Other outcomes:
Locations:
Study officials:
affiliation: The Hong Kong Polytechnic University
name: Ka Yan HO
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02906865: Proximal Hamstring Avulsion Surgery Cohort Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Proximal Hamstring Rupture
Lead sponsor: Fonds de Dotation pour la Recherche Clinique en Orthopédie et Pathologie du Sport
Sponsor class: OTHER
First posted: 2016-09-20
Enrollment: 1000
Sex: ALL
Minimum age (years): 10
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Partial or complete hamstring proximal rupture

Brief summary: Proximal hamstring rupture is a rare injury, which may be immediately diagnosed.

In 1996, Sallay showed that functional results of surgical repair were better than those of conservative treatment. Surgery is now the rule. The main aim of this study is to obtain a more detailed and quantified description of the postoperative outcomes.


Eligibility criteria: Inclusion Criteria:

* a partial or complete hamstring proximal rupture,
* treated surgically
* diagnosis of rupture based on clinical signs and confirmed on MRI

Exclusion Criteria:

* no exclusion criteria

Primary outcomes:
measure: Activity level
timeFrame: 2 years
Secondary outcomes:
measure: Return to sports
timeFrame: 1 year
measure: Healing on MRI
timeFrame: 6 months
Other outcomes:
Locations:
city: Paris
country: France
facility: Clinique du Sport
Study officials:
References:
citation: Lefevre N, Bohu Y, Naouri JF, Klouche S, Herman S. Returning to sports after surgical repair of acute proximal hamstring ruptures. Knee Surg Sports Traumatol Arthrosc. 2013 Mar;21(3):534-9. doi: 10.1007/s00167-012-2204-2. Epub 2012 Sep 13.
citation: Lefevre N, Bohu Y, Klouche S, Herman S. Surgical technique for repair of acute proximal hamstring tears. Orthop Traumatol Surg Res. 2013 Apr;99(2):235-40. doi: 10.1016/j.otsr.2012.05.006. Epub 2012 Aug 25.
Clinical trial NCT03096665: Effectiveness of Point of Care Blood Analysis Obtained From Skin Puncture Blood
Official title: Correlation Between the Point of Care Blood Analysis Obtained From Skin Puncture Blood and Conventional Blood Analysis Obtained From Venous and Arterial Blood
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cardiovascular Diseases
Acute Abdomen
Respiratory Disease
Renal Disease
Cerebrovascular Disorders
Keywords: venous blood
arterial blood
capillary blood
Lead sponsor: Hanyang University
Sponsor class: OTHER
First posted: 2017-03-30
Enrollment: 250
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The patients who require the blood test (venous blood test, skin puncture blood test and arteria blood gas analysis) of the patients presenting to the emergency department during the study period

Brief summary: This study aimed to evaluate the correlation between the point of care blood analysis obtained from skin puncture blood and conventional blood analysis obtained from venous and arterial blood.


Eligibility criteria: Inclusion Criteria:

* The patients who simultaneously require the venous blood test, skin puncture blood test and arterial blood gas analysis

Exclusion Criteria:

* Unstable patients
* Patients receiving the medications affecting the results of blood analysis.

Primary outcomes:
measure: Blood analysis between capillary blood, venous blood and arterial blood
timeFrame: within 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Guri
country: Korea, Republic of
facility: Hanyang university guri hospital, Department of emergency medicine
state: GyeongGido
Study officials:
References:
citation: Kupke IR, Kather B, Zeugner S. On the composition of capillary and venous blood serum. Clin Chim Acta. 1981 May 5;112(2):177-85. doi: 10.1016/0009-8981(81)90376-4.
citation: Sobiech P, Pomianowski A, Stopyra A, Kuleta Z, Zbanyszek M, Procajlo A, Rajski K. Acid-base balance parameters and ionic composition of arterial, venous and capillary blood in goats. Pol J Vet Sci. 2004;7(2):117-21.
citation: Blumenfeld TA, Hertelendy WG, Ford SH. Simultaneously obtained skin-puncture serum, skin-puncture plasma, and venous serum compared, and effects of warming the skin before puncture. Clin Chem. 1977 Sep;23(9):1705-10.
citation: Falch DK. Clinical chemical analyses of serum obtained from capillary versus venous blood, using Microtainers and Vacutainers. Scand J Clin Lab Invest. 1981 Feb;41(1):59-62. doi: 10.3109/00365518109092015.
Clinical trial NCT02775565: Initial Experience With the AngioVac Venous Drainage Cannula
Official title: Initial Experience With the AngioVac Venous Drainage Cannula and Cardiopulmonary Bypass Circuit: A Retrospective, Multi-Center Chart Review
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart Disease
Lead sponsor: Angiodynamics, Inc.
Sponsor class: INDUSTRY
First posted: 2016-05-17
Enrollment: 51
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients treated at each study site between February 1, 2013 and February 28, 2015 will be included.

Brief summary: This is a retrospective, record-based study of approximately 100 patients across up to 12 centers within the United States. All patients who have been treated with the AngioVac Venous Drainage Cannula and the Extracorporeal Circuit will be considered for study participation. Eligible subject must meet all of the inclusion criteria and none of the exclusion criteria to be considered enrolled in the study. The purpose of the study is to describe initial experience with the AngioVac Venous Drainage Cannula and the Extracorporeal Circuit.


Eligibility criteria: Inclusion Criteria:

* Consecutive patients treated at each study site between February 1, 2013 and February 28, 2015 will be included.

Exclusion Criteria:

* Patients treated with the AngioVac venous drainage system outside of those dates.

Primary outcomes:
measure: Detailing early clinical experience with the AngioVac Venous Drainage Cannula
timeFrame: Experience and success is determined immediately after the procedure is completed. No subject follow up data is collected and retrospective data will be reviewed.
Secondary outcomes:
Other outcomes:
Locations:
city: Burbank
country: United States
facility: Providence St. Joseph
state: California
city: Los Angeles
country: United States
facility: UCLA
state: California
city: Fargo
country: United States
facility: Sanford Research
state: North Dakota
city: Charleston
country: United States
facility: MUSC
state: South Carolina
city: Seattle
country: United States
facility: Swedish Health Services
state: Washington
Study officials:
References:
Clinical trial NCT00715065: fMRI in Blood Phobia Syncope
Official title: Neuroimaging in Blood Phobia Syncope
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Syncope
Blood Injury Phobia
Autonomic Dysfunction
Keywords: syncope
faint
blood
blood injury phobia
phobia
Lead sponsor: Vanderbilt University
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2008-07-15
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1. Patients with at least 1 prior syncopal episode in response to viewing blood
2. Healthy subjects without a history of syncope

Brief summary: We plan to study patient who faint in response to the sight of blood and compare them to healthy subjects who do not. We are going to use a special type of MRI scan (functional MRI) to determine if there are differences in brain activation in response to seeing bloody or gory pictures that occur before the fainting occurs.

Detailed description: Another aim of the study is to determine whether or not differences in personality traits among people with blood phobia is associated with differences in BOLD signal responses during fMRI.

Eligibility criteria: Inclusion Criteria:

* 18-30 years of age
* 1. History of at least one syncopal episode upon exposure to viewing blood (Case Group)
* Negative urine pregnancy test on study day

Exclusion Criteria:

* Vasoactive medications (within 2 weeks of study day)
* antihypertensives
* beta blockers
* vasoconstrictors
* Psychotropic medications (within 4 weeks of study day)
* History of psychostimulant or opiate use
* History of alcohol, benzodiazepine or cannabis abuse or dependence

Primary outcomes:
measure: fMRI BOLD signal
timeFrame: Immediate
Secondary outcomes:
measure: Blood Injection Symptoms Scale
timeFrame: Single visit
measure: Disgust Scale (Revised)
timeFrame: Single Visit
Other outcomes:
Locations:
city: Nashville
country: United States
facility: Vanderbilt University Autonomic Dysfunction Center
state: Tennessee
Study officials:
affiliation: Vanderbilt University
name: Satish R Raj, MD MSCI
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06797765: Optical Coherence Tomography Angiography in Neurological Disease
Official title: Optical Coherence Tomography Angiography in Neurological Disease: A Pilot Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Octa
Stroke
Subarachnoid Hemorrhage
Intracerebral Hemorrhage
Lead sponsor: University of Texas Southwestern Medical Center
Sponsor class: OTHER
First posted: 2025-01-28
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Control and Patient population

Brief summary: Optical Coherence Tomography Angiography (OCTA) is a non-invasive tool that images the neurovascular structures of the eye by using near-infrared light. Previous literature has demonstrated the potential of OCTA as a screening tool in stroke, but its utility in other neurological illness such as intracranial hemorrhage is unclear. Hence, this pilot study will gather preliminary data to support future grant applications to investigate this area more fully by recruiting patients with neurological illness and healthy controls and comparing their OCTA imaging parameters.


Eligibility criteria: Inclusion Criteria:

* Age 18 years or older
* Patient admitted to the neuroscience intensive care unit with a diagnosis of: subarachnoid hemorrhage, intracerebral hemorrhage, intracranial aneurysm (ruptured or unruptured), intracranial vascular malformation, ischemic stroke, seizure disorder, intracranial infection, intracranial tumor(s), inflammatory demyelinating disease, traumatic brain injury and/or neuromuscular respiratory failure OR subjects from the community without major neurologic, cardiovascular, pulmonary or metabolic disease

Exclusion Criteria:

* Pregnancy
* Non-English speaking
* GCS motor score less than 6 (i.e. must be able to follow commands)
* Temporary or permanent physical limitation that renders the patient unable to sit up and look inside OCTA device

Primary outcomes:
measure: Vascular and Perfusion Density in healthy controls
timeFrame: Once (approx. 10 mins)
measure: Vascular and Perfusion Density in Patients with neurological disease
timeFrame: Throughout study completion up to 28 days
Secondary outcomes:
Other outcomes:
Locations:
city: Dallas
country: United States
facility: UT Southwestern Medical Center
state: Texas
Study officials:
References:
citation: Patton N, Aslam T, Macgillivray T, Pattie A, Deary IJ, Dhillon B. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat. 2005 Apr;206(4):319-48. doi: 10.1111/j.1469-7580.2005.00395.x.
Clinical trial NCT04761965: Quantitative MRI of Bone Marrow Fat Fraction in Patients With Trepanobiopsy
Official title: Clinical Study of the Sensitivity and Specificity of the Quantitative Assessment of Bone Marrow Cellularity by MRI in Comparison With Trepanobiopsies in Patients With Diseases of the Hematopoietic System
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Aplastic Anemia
Aplastic Anemia Idiopathic
Keywords: Quantitative MRI
trepanobiopsy
Aplastic Anemia Idiopathic
children
Lead sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Sponsor class: OTHER
First posted: 2021-02-21
Enrollment: 150
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The study is aimed to find correlation between the assessment of cellularity according to trepanobiopsy data and the results of measuring MRI parameters.

Detailed description: The ratio of fat to water in the bone marrow depends on the cellularity of the bone marrow. In addition to the water/fat ratio in bone marrow there are also other parameters for quantitative MRI assessment. These include the apparent diffusion coefficient (ACD), the T1 relaxation time, mapping of the macromolecular proton fraction. The undoubted advantage of MRI is its non-invasiveness and the ability to assess any localization of the bone marrow.

MRI may become a new non-invasive method for assessing the cellularity of the bone marrow in children with oncohematological diseases.

Eligibility criteria: Inclusion Criteria:

presence of indications for performing trepanobiopsy:

1. aplastic anemia
2. chronic myeloproliferative disease
3. reactive changes in hematopoiesis

Exclusion Criteria:

1. Refusal to sign an informed consent to participate in a clinical trial
2. Presence of contraindications for MRI examination
3. Extremely serious condition of the patient at the time of inclusion in the study.

Primary outcomes:
measure: correlation between Bone marrow cellularity by mDixon-quant and trepanobiopsy.
timeFrame: Before the start of treatment
Secondary outcomes:
measure: T1 maping
timeFrame: Before the start of treatment
measure: apparent diffusion coefficient
timeFrame: Before the start of treatment
measure: Percentage of the macromolecular proton fraction (MPF)
timeFrame: Before the start of treatment
measure: Percentage of the bone marrow fat fraction
timeFrame: Before the start of treatment
Other outcomes:
Locations:
city: Moscow
country: Russian Federation
facility: Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology
state: Samory-Mashela,1
Study officials:
References:
Clinical trial NCT03731065: Exogenous Oxidation of Fructose-glucose Mixtures During Running
Official title: Examining Exogenous Carbohydrate Oxidation From Glucose, Multiple Transportable Carbohydrates and Hydrogel Carbohydrate Drinks During Endurance Running
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Lead sponsor: University of Bath
Sponsor class: OTHER
Collaborators: name: University of Birmingham
First posted: 2018-11-06
Enrollment: 9
Sex: MALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of this study is to characterise exogenous carbohydrate oxidation rates during exercise, when ingesting glucose (polymers) only, compared to glucose-fructose mixtures, and glucose-fructose mixtures ingested in hydrogel form.


Eligibility criteria: Inclusion Criteria:

* Maximal oxygen consumption \> 50 ml.kg-1.min-1
* \> 1 year training in endurance running or triathlon
* No current injury or injury within the last three months
* No history of cardiac or metabolic disease such as coronary heart disease or diabetes
* No current or history of gastrointestinal issues
* Successful completion of the physical activity readiness questionnaire (PAR-Q)

Exclusion Criteria:

* Female
* Untrained in endurance running
* Current injury or injury within the past three months
* History of cardiac or metabolic disease such as coronary heart disease or diabetes
* History of or current gastrointestinal issues such as irritable bowel syndrome
* Unable to replicate diet and training for 3 and 5 days respectively prior to each experimental visit.

Primary outcomes:
measure: Peak exogenous carbohydrate oxidation rate
timeFrame: 120 minutes
Secondary outcomes:
measure: Total carbohydrate oxidation
timeFrame: 120 minutes
measure: Ratings of gastrointestinal discomfort
timeFrame: 120 minutes
measure: Total fat oxidation
timeFrame: 120 minutes
measure: Plasma insulin concentrations
timeFrame: 120 minutes
measure: Plasma glucose concentrations
timeFrame: 120 minutes
measure: Plasma lactate concentrations
timeFrame: 120 minutes
measure: Plasma non-esterified fatty acid concentrations
timeFrame: 120 minutes
measure: Ratings of perceived exertion
timeFrame: 120 minutes
measure: Heart rate
timeFrame: 120 minutes
measure: Rate of oxygen consumption
timeFrame: 120 minutes
measure: Rate of carbon dioxide production
timeFrame: 120 minutes
Other outcomes:
Locations:
city: Bath
country: United Kingdom
facility: Department for Health, University of Bath
Study officials:
References:
Clinical trial NCT06969365: Weighted Blankets for IUD Insertion
Official title: Do Weighted Blankets Reduce Pain and Anxiety Associated With Gynecological Procedures?
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: PHASE1
Conditions: Intra-uterine Device Placement
Keywords: weighted blanket
gynecological procedure
IUD
anxiety
Lead sponsor: Saint Luke's Health System
Sponsor class: OTHER
First posted: 2025-05-13
Enrollment: 54
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: When having an intrauterine device placed in an outpatient clinic, patients frequently feel anxiety related to the procedure. This study is designed to determine if the use of a small, weighted blanket, placed over the patient's chest and shoulders, would help decrease that anxiety, as well as pain related to the procedure.

Detailed description: Patients scheduled for an IUD placement in this specific outpatient clinic will be approached by the study nurse to gauge interest in participating. Consented patients will be randomized to either receive a weighted blanket or a non-weighted blanket. Patients will rate their anxiety on a 100 mm visual-analog scale and pain on a 0-10 verbal scale.

Eligibility criteria: Inclusion Criteria:

* scheduled for IUD placement
* age 18 years or older
* able to read and understand English and use a pen

Exclusion Criteria:

* inability to consent
* inability to remove weighted blanket

Primary outcomes:
measure: Visual Analog Scale - Anxiety
timeFrame: At the conclusion of the procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: Saint Luke's Hospital
state: Missouri
Study officials:
affiliation: Saint Luke's Health System
name: Anna Guastello, BSN
role: PRINCIPAL_INVESTIGATOR
References:
citation: Nguyen L, Lamarche L, Lennox R, Ramdyal A, Patel T, Black M, Mangin D. Strategies to Mitigate Anxiety and Pain in Intrauterine Device Insertion: A Systematic Review. J Obstet Gynaecol Can. 2020 Sep;42(9):1138-1146.e2. doi: 10.1016/j.jogc.2019.09.014. Epub 2019 Dec 25.