Clinical trial NCT03512886: The Effect of Multiple-Task Training in Patients With Multiple Sclerosis
Official title: The Effect of Multiple-Task Training on Physical and Cognitive Functions in Patients With Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Multiple Sclerosis
Keywords: Multiple sclerosis
Multi-task training
Balance
Mobility
Cognition
Upper extremity function
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2018-05-01
Enrollment: 39
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The Activities of Daily Living requires the ability to perform multiple activities at the same time, not just the motor or cognitive activity. When many tasks are performed at the same time, the attention capacity is effectively used and attention is shared according to the difficulty and priority of the tasks. There is evidence that patients with Multiple Sclerosis (MS) have reduced performance during multitasking.

In this study, the investigators aim to investigate the effect of multitasking training on balance, mobility, upper extremity performance and cognitive functions in patients with MS.

Detailed description: Patients with MS between 0-1,5 score according to the Extended Disability Status Scale (EDSS) will be included in the study. The balance, mobility, upper extremity performance, the cognitive function will be evaluated twice.

The study was designed as a prospective, randomized controlled study. The patients will be randomly assigned to three groups, the "multi-task training (MT)" group, the "single task training (ST)" group, and "control" group. The training will be twice a week for 6 weeks.

Statistical analyses will be performed using the SPSS software version 15 (SPSS Inc. Chicago, IL, USA). The pre-training and post-training measurements of groups will be compared with the Wilcoxon Test. The significance level was set at p\< 0.05

Eligibility criteria: Inclusion Criteria:

* Participants who are ambulatory and volunteer to participate to the study, in a stable phase of the disease, without relapses in the last 3 month, with an EDSS between 0-1,5.

Exclusion Criteria:

* Participants who have orthopedic, vision, hearing, or perception problems

  * Patients who have any cardiovascular or pulmonary disease in which exercise is contraindicated

Primary outcomes:
measure: Mobility
timeFrame: ten minutes]
measure: Modified Sensory Organization Test
timeFrame: Fifteen minutes]
measure: Upper extremity function
timeFrame: ten minutes
measure: cognitive function
timeFrame: thirty minutes
Secondary outcomes:
measure: Physical Activity
timeFrame: ten minutes
measure: Fatigue Impact
timeFrame: five minutes
measure: Fatigue Severity
timeFrame: Five minutes
measure: Balance Confidence
timeFrame: five minutes
measure: Neuropsychological Questionnaire
timeFrame: one minute
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazi University
Study officials:
affiliation: Gazi University
name: Cagla Ozkul
role: PRINCIPAL_INVESTIGATOR
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