Clinical trial NCT03422822: Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis
Official title: A PHASE 3 MULTI-CENTER, LONG-TERM EXTENSION STUDY INVESTIGATING THE EFFICACY AND SAFETY OF ABROCITINIB, WITH OR WITHOUT TOPICAL MEDICATIONS, ADMINISTERED TO SUBJECTS AGED 12 YEARS AND OLDER WITH MODERATE TO SEVERE ATOPIC DERMATITIS
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Dermatitis, Atopic
Keywords: atopic dermatitis
atopic eczema
eczema
JAK
janus kinase
Magnetic Resonance Imaging
MRI
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2018-02-06
Enrollment: 3164
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: B7451015 is a Phase 3 study to evaluate Abrocitinib with or without Topical Medications in patients aged 12 years and older who have moderate to severe atopic dermatitis and have completed a qualifying parent study. The efficacy and safety of two dosage strengths of Abrocitinib, 100 mg and 200 mg taken orally once daily, will be evaluated over variable lengths of study participation. The study consists of a 92 week initial treatment period followed by a variable length secondary treatment period during which subjects will receive treatment with open-label abrocitinib until availability of commercial product in their country, or until the sponsor terminates the study in that country.

The B7451015 study also includes a sub-study evaluating whether abrocitinib has any potential effects on adolescent bone with regard to abnormal bone findings in knee MRI. The sub-study will be conducted in selected countries at selected sites. Eligible subjects are those who were 12 to \<18 years of age at the screening visit of the qualifying parent study and who are currently participating in the main B7451015 study. The sub-study will include serial Magnetic Resonance Imaging (MRI) annually and continue until all enrolled subjects are 18 years of age and have been imaged at least once or have discontinued/withdrawn.


Eligibility criteria: Inclusion Criteria:

1. Evidence of a personally signed and dated informed consent document indicating that the subject or their parent(s)/legal guardian, if applicable, have been informed of all pertinent aspects of the study.
2. Male or female subjects of 12 years of age or older, at the time of informed consent and meets inclusion criterion for minimum body weight (if applicable) from qualifying Parent study. Adolescent subjects below the age of 18 years old (or country-specific age of majority) will only be enrolled in this study if instructed by the sponsor and approved by the country or regulatory/health authority. If these approvals have not been granted, only subjects aged 18 years (or country-specific age of majority) and older will be enrolled.
3. Willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures.
4. Must have completed the full treatment period of a qualifying Parent study OR must have completed the full rescue treatment period of a qualifying Parent study (if applicable) OR must have completed the full open-label run-in period in B7451014 and did not meet the protocol-specified response criteria at Week 12.
5. Female subjects who are of childbearing potential (which includes all female subjects aged 12 years and older, regardless of whether they have experienced menarche) must ot be intending to become pregnant, currently pregnant, or lactating. The following onditions apply:

   1. Female subjects of childbearing potential must have a confirmed negative pregnancy test prior to allocation to treatment.
   2. Female subjects of childbearing potential must agree to use a highly effective method of contraception (as per Section 4.4.1) for the duration of the active treatment period and for at least 28 days after the last dose of investigational product.

For Czech Republic only, 5 b. is revised and 5 c. is added to require:

Female subjects of childbearing potential 15 years of age who are at risk of pregnancy must agree to use a highly effective method of contraception for the duration of the active treatment period and for at least 28 days after the last dose of investigational product.

c. Female subjects less than 15 years of age must not be sexually active, and abstinence per the below definition should be confirmed prior to enrollment. NOTE: Sexual abstinence, defined as completely and persistently refraining from all heterosexual intercourse (including during the entire period of risk associated with the study treatments) may obviate the need for contraception ONLY if this is the preferred and usual lifestyle of the subject.

6. Female subjects of non-childbearing potential must meet at least 1 of the following criteria:

1. Have undergone a documented hysterectomy and/or bilateral oophorectomy;
2. Have medically confirmed ovarian failure; or
3. Achieved postmenopausal status, defined as follows: cessation of regular menses for at least 12 consecutive months with no alternative pathological or physiological cause and have a serum follicle-stimulating hormone (FSH) level confirming the postmenopausal state. All other female subjects (including female subjects with tubal ligations) are considered to be of childbearing potential. 7. Must agree to avoid prolonged exposure to the sun and not to use tanning booths, sun lamps or other ultraviolet light sources during the study.

   8. Must agree to avoid use of prohibited medications throughout the duration of the study. Exclusion Criteria
   1. Other acute or chronic medical or psychiatric condition including recent (within the past year) or active suicidal ideation or behavior or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study.
   2. Currently have active forms of other inflammatory skin diseases, ie, not AD or have evidence of skin conditions (eg, psoriasis, seborrheic dermatitis, Lupus) at the time of Day -1 that would interfere with evaluation of atopic dermatitis or response to treatment.
   3. Discontinued from treatment (or rescue treatment period/open-label run-in period, if applicable) early in a qualifying Parent study OR triggered a discontinuation criterion at any point during the qualifying Parent study which in the opinion of the investigator, or sponsor, is an ongoing safety concern.
   4. Ongoing adverse event in the qualifying Parent study which in the opinion of the investigator, or sponsor, is an ongoing safety concern.
   5. Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or subjects who are Pfizer employees, including their family members, directly involved in the conduct of the study.

   There are also additional separate inclusion and exclusion criteria to assess eligibility specifically for the B7451015 MRI sub-study.

Primary outcomes:
measure: Treatment emergent adverse events
timeFrame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
measure: Serious adverse events and adverse events leading to discontinuation
timeFrame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
measure: Change from baseline in clinical laboratory values
timeFrame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
measure: Change from baseline in electrocardiogram (ECG) measurements
timeFrame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
measure: Change from baseline in vital signs
timeFrame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
Secondary outcomes:
measure: Investigator's Global Assessment (IGA)
timeFrame: Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
measure: Eczema Area and Severity Index (EASI)
timeFrame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
measure: Pruritus Numerical Rating Scale (NRS)
timeFrame: Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
measure: Patient Global Assessment (PtGA)
timeFrame: Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
measure: Body Surface Area (BSA) affected
timeFrame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
measure: Dermatology Life Quality Index (DLQI) or Children's DLQI (CDLQI)
timeFrame: Baseline, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
measure: Patient Oriented Eczema Measure (POEM)
timeFrame: Baseline, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92
measure: Hospital Anxiety and Depression Scale (HADS)
timeFrame: Baseline, Week 12, Week 24, Week 36, Week 48, Week 60, Week 64, Week 72, Week 84, Week 92, Week 96
measure: EuroQol Quality of Life 5 Dimension 5 Level Scale (EQ-5D-5L) or EuroQol Quality of Life 5 Dimension Youth Scale (EQ-5D-Y)
timeFrame: Baseline, Week 24, Week 48, Week 60, Week 72, Week 92
measure: Steroid-Free Days
timeFrame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
measure: Serum Hs-CRP Levels
timeFrame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
measure: Change in height standard deviation score (SDS)
timeFrame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years
measure: Proportion of abnormal findings in knee MRI in adolescent subjects exposed to abrocitinib 100mg and 200mg QD
timeFrame: Throughout sub-study until all enrolled subjects are 18 years of age and have been imaged at least once or have discontinued or withdrawn; an estimated maximum of 4 years
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Total Skin and Beauty Dermatology Center, PC
state: Alabama
city: Birmingham
country: United States
facility: Clinical Research Center of Alabama, LLC
state: Alabama
city: Birmingham
country: United States
facility: University of Alabama at Birmingham - Dermatology Research Clinic
state: Alabama
city: Birmingham
country: United States
facility: University of Alabama at Birmingham Hospital Outreach Lab
state: Alabama
city: Birmingham
country: United States
facility: Clinical Research Center of Alabama, LLC
state: Alabama
city: Birmingham
country: United States
facility: The University of Alabama at Birmingham, Department of Dermatology
state: Alabama
city: Anaheim
country: United States
facility: Emmaus Research Center, Inc.
state: California
city: Encinitas
country: United States
facility: California Dermatology & Clinical Research Institute
state: California
city: Fountain Valley
country: United States
facility: First OC Dermatology Research Inc
state: California
city: Huntington Beach
country: United States
facility: Marvel Research, LLC
state: California
city: Irvine
country: United States
facility: Tilda Research Inc.
state: California
city: Long Beach
country: United States
facility: Beach Allergy and Asthma Specialty Group, A Medical Corporation
state: California
city: Los Angeles
country: United States
facility: Keck School of Medicine of University of Southern California
state: California
city: Los Angeles
country: United States
facility: Wallace Medical Group, Inc
state: California
city: Mission Viejo
country: United States
facility: Allergy & Asthma Associates of Southern California dba Southern California Research
state: California
city: Oceanside
country: United States
facility: Dermatology Specialists, Inc.
state: California
city: Rolling Hills Estates
country: United States
facility: Peninsula Headlands LLC
state: California
city: Sacramento
country: United States
facility: UC Davis Health
state: California
city: San Diego
country: United States
facility: MedDerm Associates
state: California
city: San Diego
country: United States
facility: University of California San Diego Dermatology
state: California
city: San Francisco
country: United States
facility: Synergy Dermatology
state: California
city: San Luis Obispo
country: United States
facility: San Luis Dermatology and Laser Clinic
state: California
city: Santa Ana
country: United States
facility: Southern California Dermatology, Inc.
state: California
city: Santa Ana
country: United States
facility: Wolverine Clinical Trials, Llc
state: California
city: Santa Monica
country: United States
facility: Mosaic Dermatology
state: California
city: Santa Monica
country: United States
facility: Clinical Science Institute
state: California
city: Colorado Springs
country: United States
facility: Asthma and Allergy Associates, PC
state: Colorado
city: Colorado Springs
country: United States
facility: Colorado Springs Dermatology Clinic, PC
state: Colorado
city: Boca Raton
country: United States
facility: Skin Care Research
state: Florida
city: Cape Coral
country: United States
facility: Renaissance Research and Medical Group, Inc
state: Florida
city: Coral Gables
country: United States
facility: Florida Academic Centers Research and Education, LLC
state: Florida
city: Coral Gables
country: United States
facility: Skin Research Institute
state: Florida
city: Doral
country: United States
facility: Moonshine Research Center, Inc.
state: Florida
city: Homestead
country: United States
facility: Homestead Research Institute
state: Florida
city: Jacksonville
country: United States
facility: Clinical Neuroscience Solutions, Inc.
state: Florida
city: Jacksonville
country: United States
facility: Solutions Through Advanced Research, Inc.
state: Florida
city: Kendall
country: United States
facility: C & R Research Services USA, Inc
state: Florida
city: Miami Lakes
country: United States
facility: Savin Medical Group LLC
state: Florida
city: Miami Lakes
country: United States
facility: Wellness Clinical Research, LLC
state: Florida
city: Miami
country: United States
facility: Clinical Trials Solutions
state: Florida
city: Miami
country: United States
facility: Global Health Clinical Trials Corp
state: Florida
city: Miami
country: United States
facility: Baumann Cosmetic and Research Institute
state: Florida
city: Miami
country: United States
facility: Suncoast Research Associates
state: Florida
city: Miami
country: United States
facility: La Salud Research Clinic, Inc.
state: Florida
city: Miami
country: United States
facility: Nicklaus Children's Hospital
state: Florida
city: Miami
country: United States
facility: South Miami Medical & Research Group, Inc.
state: Florida
city: Miami
country: United States
facility: Ciocca Dermatology, PA
state: Florida
city: Miami
country: United States
facility: Miami Dermatology & Laser Research, LLC
state: Florida
city: Miami
country: United States
facility: INTERMED Medical Research Center, Inc
state: Florida
city: Miami
country: United States
facility: Suncoast Research Associates
state: Florida
city: Orange Park
country: United States
facility: Park Avenue Dermatology
state: Florida
city: Orlando
country: United States
facility: Clinical Neuroscience Solutions, Inc.
state: Florida
city: Orlando
country: United States
facility: AdventHealth Orlando
state: Florida
city: Orlando
country: United States
facility: AdventHealth Pediatric Dermatology Orlando
state: Florida
city: Orlando
country: United States
facility: Advent Health Orlando - Investigational Drug Services
state: Florida
city: Orlando
country: United States
facility: Outpatient Services Center - AdventHealth Orlando
state: Florida
city: Orlando
country: United States
facility: Pediatric Outpatient Procedures and Sedation
state: Florida
city: Orlando
country: United States
facility: Accel Research Sites - Nona Pediatric Center
state: Florida
city: Saint Petersburg
country: United States
facility: Olympian Clinical Research
state: Florida
city: Tampa
country: United States
facility: Clinical Research Trials of Florida, Inc.
state: Florida
city: Tampa
country: United States
facility: Clinical Research Trials of Florida
state: Florida
city: Tampa
country: United States
facility: ForCare Clinical Research
state: Florida
city: Tampa
country: United States
facility: University of South Florida; Asthma, Allergy and Immunology Clinical Research Unit
state: Florida
city: Tampa
country: United States
facility: Olympian Clinical Research
state: Florida
city: West Palm Beach
country: United States
facility: Integrated Clinical Research
state: Florida
city: Columbus
country: United States
facility: Columbus Regional Research Institute
state: Georgia
city: Columbus
country: United States
facility: IACT Health
state: Georgia
city: Johns Creek
country: United States
facility: One Health Research Clinic Atlanta, LLC
state: Georgia
city: Macon
country: United States
facility: Dermatologic Surgery Specialists, PC
state: Georgia
city: Savannah
country: United States
facility: Meridian Clinical Research
state: Georgia
city: Nampa
country: United States
facility: ASR, LLC
state: Idaho
city: Normal
country: United States
facility: Midwest Allergy Sinus Asthma, SC
state: Illinois
city: Skokie
country: United States
facility: NorthShore University HealthSystem - Dermatology
state: Illinois
city: Skokie
country: United States
facility: NorthShore University HealthSystem Dermatology Clinical Trials Unit
state: Illinois
city: West Dundee
country: United States
facility: Dundee Dermatology
state: Illinois
city: Clarksville
country: United States
facility: Ds Research
state: Indiana
city: Indianapolis
country: United States
facility: Dawes Fretzin Clinical Research Group, LLC
state: Indiana
city: Plainfield
country: United States
facility: The Indiana Clinical Trials Center
state: Indiana
city: South Bend
country: United States
facility: The South Bend Clinic Center for Research
state: Indiana
city: Overland Park
country: United States
facility: Kansas City Dermatology, PA
state: Kansas
city: Louisville
country: United States
facility: Skin Sciences, PLLC
state: Kentucky
city: Owensboro
country: United States
facility: Qualmedica Research, LLC.
state: Kentucky
city: Owensboro
country: United States
facility: Owensboro Dermatology Associates
state: Kentucky
city: Baton Rouge
country: United States
facility: Meridian Clinical Research, LLC
state: Louisiana
city: Crowley
country: United States
facility: Avant Research Associates LLC
state: Louisiana
city: New Orleans
country: United States
facility: Tulane University Health Sciences Center
state: Louisiana
city: Chevy Chase
country: United States
facility: Institute for Asthma and Allergy
state: Maryland
city: Rockville
country: United States
facility: DermAssociates, LLC
state: Maryland
city: White Marsh
country: United States
facility: Chesapeake Clinical Research, Inc.
state: Maryland
city: Boston
country: United States
facility: Tufts Medical Center
state: Massachusetts
city: Boston
country: United States
facility: Massachusetts General Hospital - Clinical Unit for Research Trials in Skin (CURTIS)
state: Massachusetts
city: Brighton
country: United States
facility: MetroBoston Clinical Partners, LLC
state: Massachusetts
city: Clarkston
country: United States
facility: Clarkston Skin Research
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Medical Center, New Center One
state: Michigan
city: Flint
country: United States
facility: Onyx Clinical Research
state: Michigan
city: Fort Gratiot
country: United States
facility: Hamzavi Dermatology
state: Michigan
city: Troy
country: United States
facility: Revival Research Institute, LLC
state: Michigan
city: Troy
country: United States
facility: Somerset Skin Centre
state: Michigan
city: West Bloomfield
country: United States
facility: Henry Ford Medical Center - Farmington Road
state: Michigan
city: Minneapolis
country: United States
facility: Clinical Research Institute, Inc.
state: Minnesota
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
city: Saint Joseph
country: United States
facility: MediSearch Clinical Trials
state: Missouri
city: Saint Louis
country: United States
facility: Saint Louis University Dermatology
state: Missouri
city: Omaha
country: United States
facility: Skin Specialists PC
state: Nebraska
city: Kew Gardens
country: United States
facility: Forest Hills Dermatology Group
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai
state: New York
city: Rochester
country: United States
facility: UR Dermatology Clinical Trials Unit at College Town
state: New York
city: Rochester
country: United States
facility: Investigational Drug Service
state: New York
city: Cary
country: United States
facility: Cary Dermatology Center, PA
state: North Carolina
city: Cary
country: United States
facility: Accellacare - Cary
state: North Carolina
city: Greensboro
country: United States
facility: Medication Management, LLC
state: North Carolina
city: Raleigh
country: United States
facility: M3-Wake Research, Inc.
state: North Carolina
city: Shelby
country: United States
facility: Carolina Research Center, Inc.
state: North Carolina
city: Wilmington
country: United States
facility: PMG Research of Wilmington LLC
state: North Carolina
city: Wilmington
country: United States
facility: PMG Research of Wilmington, LLC
state: North Carolina
city: Winston-Salem
country: United States
facility: PMG Research of Winston-Salem, LLC
state: North Carolina
city: Winston-Salem
country: United States
facility: Winston-Salem Dermatology and Surgery Center, PLLC
state: North Carolina
city: Bexley
country: United States
facility: Bexley Dermatology Research
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University Wexner Medical Center
state: Ohio
city: Gahanna
country: United States
facility: The Ohio State University Dermatology East
state: Ohio
city: Oklahoma City
country: United States
facility: Lynn Health Science Institute
state: Oklahoma
city: Oklahoma City
country: United States
facility: Newton Clinical Research
state: Oklahoma
city: Tulsa
country: United States
facility: Vital Prospects Clinical Research Institute, P.C.
state: Oklahoma
city: Clackamas
country: United States
facility: Portland Clinical Research dba Columbia Asthma & Allergy Clinic
state: Oregon
city: Medford
country: United States
facility: Velocity Clinical Research, Medford
state: Oregon
city: Portland
country: United States
facility: Oregon Medical Research Center
state: Oregon
city: Portland
country: United States
facility: Oregon Health & Science University
state: Oregon
city: Philadelphia
country: United States
facility: Paddington Testing Co, Inc.
state: Pennsylvania
city: Anderson
country: United States
facility: Synexus Clinical Research US, Inc.
state: South Carolina
city: Charleston
country: United States
facility: MUSC SCTR Research Nexus Clinic and Laboratory
state: South Carolina
city: Rapid City
country: United States
facility: Health Concepts
state: South Dakota
city: Memphis
country: United States
facility: Tanenbaum Dermatology Center
state: Tennessee
city: Memphis
country: United States
facility: Clinical Neuroscience Solutions, Inc.
state: Tennessee
city: Murfreesboro
country: United States
facility: International Clinical Research - Tennessee LLC
state: Tennessee
city: Arlington
country: United States
facility: Arlington Research Center, Inc.
state: Texas
city: Bellaire
country: United States
facility: The University of Texas Health Science Center Houston
state: Texas
city: Dallas
country: United States
facility: Menter Dermatology Research Institute
state: Texas
city: Houston
country: United States
facility: Center for Clinical Studies, LTD. LLP
state: Texas
city: Hurst
country: United States
facility: Ventavia Research Group
state: Texas
city: Pflugerville
country: United States
facility: Austin Institute for Clinical Research, Inc.
state: Texas
city: San Antonio
country: United States
facility: Texas Dermatology and Laser Specialists
state: Texas
city: San Antonio
country: United States
facility: Dermatology Clinical Research Center of San Antonio
state: Texas
city: Webster
country: United States
facility: Center for Clinical Studies, LTD.LLP
state: Texas
city: Franklin
country: United States
facility: Summit Clinical Research, LLC
state: Virginia
city: Norfolk
country: United States
facility: Virginia Clinical Research, Inc
state: Virginia
city: Norfolk
country: United States
facility: Virginia Dermatology and Skin Cancer Center
state: Virginia
city: Norfolk
country: United States
facility: Fort Norfolk Diagnostic Center
state: Virginia
city: Lakewood
country: United States
facility: Pace Dermatology Associates
state: Washington
city: Seattle
country: United States
facility: Dermatology Associates of Seattle
state: Washington
city: Spokane
country: United States
facility: Dermatology Specialists of Spokane
state: Washington
city: Spokane
country: United States
facility: Principle Research Solutions
state: Washington
city: Tacoma
country: United States
facility: MultiCare Allenmore Hospital
state: Washington
city: Tacoma
country: United States
facility: Multicare Institute for Research and Innovation
state: Washington
city: Tacoma
country: United States
facility: Pace Dermatology Associates
state: Washington
city: Milwaukee
country: United States
facility: Children's Hospital of Wisconsin Investigational Drug Service
state: Wisconsin
city: Milwaukee
country: United States
facility: Children's Hospital of Wisconsin Translational Research Unit
state: Wisconsin
city: Caba
country: Argentina
facility: CONEXA Investigación Clínica S.A.
state: Buenos Aires
city: La Plata
country: Argentina
facility: Framingham Centro Medico
state: Buenos Aires
city: Pilar
country: Argentina
facility: Hospital Universitario Austral
state: Buenos Aires
city: Rosario
country: Argentina
facility: Servicio de Investigacion de Patolog-ias Alergicas del Instituto ABC - Rosario
state: Santa FE
city: C.a.b.a.
country: Argentina
facility: Psoriahue Medicina Interdisciplinaria
city: C.a.b.a
country: Argentina
facility: CINME Centro de Investigaciones Metabolicas
city: Phillip
country: Australia
facility: Woden Dermatology
state: Australian Capital Territory
city: Kogarah
country: Australia
facility: St George Dermatology & Skin Cancer Centre
state: New South Wales
city: Maroubra
country: Australia
facility: Australian Clinical Research Network
state: New South Wales
city: St Leonards
country: Australia
facility: Royal North Shore Hospital
state: New South Wales
city: Westmead
country: Australia
facility: The Skin Hospital
state: New South Wales
city: Benowa
country: Australia
facility: The Skin Centre
state: Queensland
city: Woolloongabba
country: Australia
facility: Veracity Clinical Research Pty Ltd
state: Queensland
city: Campbelltown
country: Australia
facility: North Eastern Health Specialists
state: South Australia
city: Box Hill
country: Australia
facility: Eastern Health - Box Hill Hospital
state: Victoria
city: Carlton
country: Australia
facility: Skin Health Institute Inc.
state: Victoria
city: East Melbourne
country: Australia
facility: Sinclair Dermatology
state: Victoria
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Parkville
country: Australia
facility: The Royal Children's Hospital
state: Victoria
city: Camberwell
country: Australia
facility: Emeritus Research
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
city: Saint Leonards NSW
country: Australia
facility: Royal North Shore Hospital
city: Brussels
country: Belgium
facility: University Hospital Brussels
city: Bruxelles
country: Belgium
facility: Cliniques Universitaires Saint-Luc
city: Edegem
country: Belgium
facility: University Hospital Antwerp
city: Rio de Janeiro
country: Brazil
facility: Instituto de Dermatologia e Estética do Brasil LTDA
state: RJ
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre (HCPA)
state: RS
city: Porto Alegre
country: Brazil
facility: Associacao dos Funcionarios Públicos do Estado do Rio Grande do Sul - Hospital Ernesto Dornelles
state: RS
city: Santo Andre
country: Brazil
facility: Fundacao do ABC - Faculdade de Medicina do ABC
state: SP
city: Santo Andre
country: Brazil
facility: Tecnolab Medicina Diagnostica
state: SP
city: Santo Andre
country: Brazil
facility: Pesquisare Saude S/S Ltda
state: SP
city: Sao Bernardo do Campo
country: Brazil
facility: Tecnolab - Unidade Matriz
state: SP
city: Rio de Janeiro
country: Brazil
facility: IBPClin Pesquisa Clinica
city: Dobrich
country: Bulgaria
facility: MHAT Dobrich AD
city: Dupnitsa
country: Bulgaria
facility: MC Asklepii" OOD
city: Gabrovo
country: Bulgaria
facility: MHAT ''Dr. Tota Venkova'' AD
city: Sofia
country: Bulgaria
facility: "Acibadem City Clinic MHAT Tokuda" EAD
city: Sofia
country: Bulgaria
facility: "DCC Aleksandrovska" EOOD
city: Sofia
country: Bulgaria
facility: "DCC Fokus-5-Medical Establishment for OutpatientCare"EOOD
city: Sofia
country: Bulgaria
facility: Military Medical Academy MHAT Sofia
city: Sofia
country: Bulgaria
facility: Dermatology Clinic "Sofia" - group practice for specialized outpatient medical care
city: Sofia
country: Bulgaria
facility: "Mc Synexus Sofia" Eood
city: Sofia
country: Bulgaria
facility: ACIBADEM City Clinic Diagnostic-Consultative Center EOOD
city: Stara Zagora
country: Bulgaria
facility: Medical Center Synexus Sofia EOOD-branch Stara Zagora
city: Varna
country: Bulgaria
facility: "ACIBADEM City Clinic Medical Center Varna" EOOD
city: Varna
country: Bulgaria
facility: "DCC Mladost-M Varna" OOD
city: Calgary
country: Canada
facility: Dermatology Research Institute
state: Alberta
city: Calgary
country: Canada
facility: Dermatology Research Institute
state: Alberta
city: Calgary
country: Canada
facility: Beacon Dermatology
state: Alberta
city: Edmonton
country: Canada
facility: Stratica Medical
state: Alberta
city: Edmonton
country: Canada
facility: Alberta Dermasurgery Centre
state: Alberta
city: Red Deer
country: Canada
facility: CARE Clinic Ltd
state: Alberta
city: Surrey
country: Canada
facility: Dr. Chih-ho Hong Medical Inc
state: British Columbia
city: Vancouver
country: Canada
facility: University of British Columbia Department of Dermatology and Skin Science
state: British Columbia
city: Vancouver
country: Canada
facility: Pacific Dermaesthetics Inc.
state: British Columbia
city: Winnipeg
country: Canada
facility: Winnipeg Clinic
state: Manitoba
city: Winnipeg
country: Canada
facility: Wiseman Dermatology Research Inc.
state: Manitoba
city: St. John's
country: Canada
facility: Karma Clinical Trials, Inc.
state: Newfoundland and Labrador
city: Ajax
country: Canada
facility: CCA Medical Research
state: Ontario
city: Barrie
country: Canada
facility: SimcoDerm Medical and Surgical Dermatology Center
state: Ontario
city: Etobicoke
country: Canada
facility: Kingsway Clinical Research
state: Ontario
city: London
country: Canada
facility: Derm Effects
state: Ontario
city: Markham
country: Canada
facility: Lynderm Research Inc.
state: Ontario
city: Mississauga
country: Canada
facility: DermEdge Research
state: Ontario
city: North Bay
country: Canada
facility: North Bay Dermatology Centre
state: Ontario
city: Oakville
country: Canada
facility: The Centre for Clinical Trials
state: Ontario
city: Oshawa
country: Canada
facility: Oshawa Clinic Dermatology Trials
state: Ontario
city: Ottawa
country: Canada
facility: Dermatology Ottawa Research Centre
state: Ontario
city: Peterborough
country: Canada
facility: SKiN Centre for Dermatology
state: Ontario
city: Richmond Hill
country: Canada
facility: The Centre for Dermatology
state: Ontario
city: Richmond Hill
country: Canada
facility: York Dermatology Clinic and Research Centre
state: Ontario
city: Sudbury
country: Canada
facility: Medicor Research Inc
state: Ontario
city: Sudbury
country: Canada
facility: Sudbury Skin Clinique
state: Ontario
city: Toronto
country: Canada
facility: North York Research Inc.
state: Ontario
city: Toronto
country: Canada
facility: Toronto Research Centre
state: Ontario
city: Toronto
country: Canada
facility: Research Toronto
state: Ontario
city: Toronto
country: Canada
facility: AvantDerm
state: Ontario
city: Toronto
country: Canada
facility: Manna Research Inc.(Toronto)
state: Ontario
city: Waterloo
country: Canada
facility: K.Papp Clinical Research Inc.
state: Ontario
city: Windsor
country: Canada
facility: XLR8 Medical Research Inc.
state: Ontario
city: Chicoutimi
country: Canada
facility: Clinique de Radiologie du Saguenay Enr.
state: Quebec
city: Chicoutimi
country: Canada
facility: Intermed groupe santé
state: Quebec
city: Montreal
country: Canada
facility: Innovaderm Research Inc.
state: Quebec
city: Sherbrooke
country: Canada
facility: Diex Research Sherbrooke Inc.
state: Quebec
city: Regina
country: Canada
facility: Dr. Rachel Asiniwasis, Medical Professional Corp.
state: Saskatchewan
city: Quebec
country: Canada
facility: Centre de Recherche Dermatologique du Quebec metropolitain (CRDQ)
city: Quebec
country: Canada
facility: Centre de Recherche Saint-Louis
city: Santiago
country: Chile
facility: Centro Medico SkinMed Limitada
state: Region Metropolitana
city: Santiago
country: Chile
facility: Clinica Dermacross S.A.
state: Region Metropolitana
city: Santiago
country: Chile
facility: Centro Internacional de Estudios Clinicos - CIEC
state: Region Metropolitana
city: Santiago
country: Chile
facility: CEC Spa
state: Región Metropolitana
city: Santiago
country: Chile
facility: MIRES (M Y F Estudios Clínicos Limitada)
state: Región Metropolitana
city: Santiago
country: Chile
facility: Hospital Clinico Universidad de Chile
state: Región Metropolitana
city: Beijing
country: China
facility: Peking University First Hospital
state: Beijing
city: Beijing
country: China
facility: Beijing Friendship Hospital, Capital Medical University
state: Beijing
city: Fuzhou
country: China
facility: The First Affiliated Hospital Of Fujian Medical University
state: Fujian
city: Guangzhou
country: China
facility: The First Affiliated Hospital, Sun Yat-sen University
state: Guangdong
city: Guangzhou
country: China
facility: The Third Affiliated Hospital, Sun Yat-sen University
state: Guangdong
city: Shenzhen
country: China
facility: The University of Hong Kong - Shenzhen Hospital
state: Guangdong
city: Wuhan
country: China
facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
state: Hubei
city: Changsha
country: China
facility: The second Xiangya Hospital,Central South University
state: Hunan
city: Changsha
country: China
facility: The Third Xiangya Hospital of Central South University, Dermatological department
state: Hunan
city: Nanjing
country: China
facility: The First Affiliated Hospital With Nanjing University
state: Jiangsu
city: Nanchang
country: China
facility: Dermatology Hospital of Jiangxi Province
state: Jiangxi
city: Jinan
country: China
facility: Jinan Central Hospital
state: Shandong
city: Jinan
country: China
facility: Shandong Provincial Institute of Dermatology and Venereology & Shandong Provincial Hospital for Skin
state: Shandong
city: Shanghai
country: China
facility: Huashan Hospital Fudan University
state: Shanghai
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital, Dermatological Department
state: Tianjin
city: Kunming
country: China
facility: First Affiliated Hospital of Kunming Medical University
state: Yunnan
city: Hangzhou
country: China
facility: The First Affiliated Hospital of Zhejiang University School of Medicine/Dermatology and STD Dept
state: Zhejiang
city: Hangzhou
country: China
facility: Hangzhou Third Hospital
state: Zhejiang
city: Hangzhou
country: China
facility: The Second Affiliated Hospital of Zhejiang University School of Medicine/Dermatology Dept
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Provincial People's Hospital/Dermatology Department
state: Zhejiang
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
state: Zhejiang
city: Chongqing
country: China
facility: The Second Affiliated Hospital of Army Medical University,PLA
city: Shanghai
country: China
facility: Dermatology Department, Shanghai Changzheng Hospital
city: Shanghai
country: China
facility: Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine/Dermatology
city: Shanghai
country: China
facility: Shanghai Dermatology Hospital
city: Kunta Hora
country: Czechia
facility: Lekarna Pod Kankem
city: Kutná Hora
country: Czechia
facility: Kozni ambulance Kutna Hora, s.r.o
city: Nachod
country: Czechia
facility: Dermamedica S.R.O.
city: Nachod
country: Czechia
facility: Lekarna U Stribrneho orla (Pharmacy)
city: Ostrava - Poruba
country: Czechia
facility: Lekarna Fakultni Nemocnice Ostrava
city: Ostrava - Poruba
country: Czechia
facility: Fakultni Nemocnice Ostrava, Kozni oddeleni
city: Ostrava
country: Czechia
facility: CCR Ostrava, s.r.o.
city: Ostrava
country: Czechia
facility: Lekarna Rezidence Nova Karolina
city: Ostrava
country: Czechia
facility: Apavar Lekarna
city: Pardubice
country: Czechia
facility: BENU Lekarna
city: Pardubice
country: Czechia
facility: PRATIA Pardubice a.s.
city: Pardubice
country: Czechia
facility: Lekarna, Nemocnice Pardubickeho kraje, a.s. , Pardubicka nemocnice
city: Pardubice
country: Czechia
facility: Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice
city: Praha 10
country: Czechia
facility: Lekarna Pod Platany (Pharmacy)
city: Praha 1
country: Czechia
facility: Prof. MUDr.Petr Arenberger, DrSc. MBA
city: Praha 3
country: Czechia
facility: PRATIA Prague s.r.o.
city: Praha
country: Czechia
facility: Lekarna U Spasitele
city: Svitavy
country: Czechia
facility: Dermatovenerologicka ambulance
city: Svitavy
country: Czechia
facility: Lekarna na Hranicni (Pharmacy)
city: Usti nad Labem
country: Czechia
facility: Krajska zdravotni a.s., Masarykova nemocnice o.z.
city: Usti nad Labem
country: Czechia
facility: Lekarna Masarykovy nemocnice v Usti nad Labem, o.z.
city: Tampere
country: Finland
facility: Terveystalo Tampere
city: Turku
country: Finland
facility: Mehiläinen Neo
city: Turku
country: Finland
facility: Turun yliopistollinen keskussairaala
city: Augsburg
country: Germany
facility: Dermazentrum Augsburg
city: Augsburg
country: Germany
facility: Licca Clinical Research Institute
city: Bad Bentheim
country: Germany
facility: Fachklinik Bad Bentheim
city: Berlin
country: Germany
facility: Charite-Universitaetsmedizin Berlin
city: Berlin
country: Germany
facility: Hautzentrum Friedrichshain Studien
city: Berlin
country: Germany
facility: Rothhaar Studien GmbH
city: Berlin
country: Germany
facility: ISA GmbH
city: Bielefeld
country: Germany
facility: Klinikum Bielefeld Rosenhoehe
city: Bonn
country: Germany
facility: Universitaetsklinikum Bonn
city: Dresden
country: Germany
facility: Klinische Forschung Dresden GmbH
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus der Technischen Universitaet Dresden
city: Erlangen
country: Germany
facility: Universitätsklinikum Erlangen
city: Frankfurt
country: Germany
facility: IKF Pneumologie GmbH & Co KG; Institut für klinische Forschung
city: Gera
country: Germany
facility: SRH Wald-Klinikum Gera GmbH
city: Hamburg
country: Germany
facility: Klinische Forschung Hamburg GmbH
city: Hamburg
country: Germany
facility: MENSINGDERMA research GmbH
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein, Campus Kiel
city: Langenau
country: Germany
facility: Praxis Dr. med. Beate Schwarz
city: Leipzig
country: Germany
facility: Velocity Clinical Research Germany GmbH
city: Luebeck
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein, Campus Luebeck
city: Mahlow
country: Germany
facility: Dermatologische Gemeinschaftspraxis
city: Mainz
country: Germany
facility: Dermatologische Gemeinschaftspraxis Dres. Quist
city: Marburg
country: Germany
facility: Universitätsklinikum Marburg
city: Muenster
country: Germany
facility: University of Muenster
city: Munich
country: Germany
facility: Ludwig-Maximilians-University Munich
city: Schwerin
country: Germany
facility: Klinische Forschung Schwerin GmbH
city: Stuttgart
country: Germany
facility: Hautaerztliche Gemeinschaftspraxis Dres. Leitz und Kollegen
city: Budapest
country: Hungary
facility: Clinexpert Kft.
city: Budapest
country: Hungary
facility: SE AOK Bor, Nemikortani es Boronkologiai Klinika
city: Budapest
country: Hungary
facility: Bp. Főváros XIX. Kerület Önkormányzat Kispesti Eü. Intézete
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont
city: Encs
country: Hungary
facility: CRU Hungary Kft.
city: Gyula
country: Hungary
facility: Synexus Magyarország Egészségügyi Szolgáltató Kft. Synexus Gyula DRS
city: Gyöngyös
country: Hungary
facility: Bugát Pál Kórház, Bőrgyógyászati Szakrendelés
city: Győr
country: Hungary
facility: Trial Pharma Kft.
city: Kaposvár
country: Hungary
facility: Trial Pharma Kft.
city: Miskolc
country: Hungary
facility: Borsod-Abaúj-Zemplén Megyei Központi Kórház és Gyermek Gasztroenterológia II. emelet
city: Pecs
country: Hungary
facility: Pecsi Tudomanyegyetem Klinikai Kozpont, Bor-,Nemikortani es Onkodermatologiai Klinika
city: Püspökladány
country: Hungary
facility: Trial Pharma Kft.
city: Szeged
country: Hungary
facility: Szegedi Tudomanyegyetem Szent-Györgyi Albert
city: Szolnok
country: Hungary
facility: ALLERGO-DERM BAKOS Kft.
city: Veszprem
country: Hungary
facility: Medmare Bt
city: Beer Sheva
country: Israel
facility: Soroka University Medical Center
city: Petah Tikva
country: Israel
facility: Rabin Medical Center
city: Ramat-Gan
country: Israel
facility: The Chaim Sheba Medical Center
city: Tel-Aviv
country: Israel
facility: Tel-Aviv Sourasky Medical Center
city: Bologna
country: Italy
facility: AOU Policlinico Sant'Orsola Malpighi
state: BO
city: Chieti
country: Italy
facility: Universita degli Studi G. D'Annunzio -CeSi-MeT
state: CH
city: Genova
country: Italy
facility: Ospedale Policlinico San Martino
state: GE
city: Modena
country: Italy
facility: AOU Policlinico di Modena Struttura complessa di Dermatologia
state: MO
city: Milano
country: Italy
facility: ASST Fatebenefratelli Sacco
city: Milan
country: Italy
facility: Istituto Clinico Humanitas IRCSS - UOC di Dermatologia
city: Roma
country: Italy
facility: IFO lstituto Dermatologico San Gallicano IRCCS
city: Rome
country: Italy
facility: Universita del Sacro Cuore, Policlinico Agostino Gemelli, Istituto Di Dermatologia
city: Ichikawa
country: Japan
facility: Kawashima Dermatology Clinic
state: Chiba
city: Obihiro
country: Japan
facility: Takagi Dermatological Clinic
state: Hokkaido
city: Kobe
country: Japan
facility: Dermatology Shimizu Clinic
state: Hyogo
city: Yokohama
country: Japan
facility: Queen's square Medical Facilities Queen's square Dermatology and Allergology
state: Kanagawa
city: Kamimashiki-gun
country: Japan
facility: Noguchi Dermatology Clinic
state: Kumamoto
city: Habikino
country: Japan
facility: Osaka Habikino Medical Center
state: Osaka
city: Neyagawa
country: Japan
facility: Yoshioka Dermatology Clinic
state: Osaka
city: Sakai
country: Japan
facility: Dermatology and Ophthalmology Kume Clinic
state: Osaka
city: Chiyoda-ku
country: Japan
facility: Iidabashi Skin Clinic
state: Tokyo
city: Chuo-ku
country: Japan
facility: Fukuwa Clinic
state: Tokyo
city: Edogawa-ku
country: Japan
facility: Sumire Dermatology Clinic
state: Tokyo
city: Nakano-ku
country: Japan
facility: Matsuyama Dermatology Clinic
state: Tokyo
city: Shinjyuku-ku
country: Japan
facility: Tokyo Medical University Hospital
state: Tokyo
city: Fukuoka
country: Japan
facility: Hoshikuma Dermatology・Allergy Clinic
city: Fukuoka
country: Japan
facility: Matsuda Tomoko Dermatological Clinic
city: Saitama
country: Japan
facility: Sanrui Hifuka
city: Ansan-si
country: Korea, Republic of
facility: Korea University Ansan Hospital
state: Gyeonggi-do
city: Bucheon-si
country: Korea, Republic of
facility: Soon Chun Hyang University Bucheon Hospital
state: Gyeonggi-do
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Hospital
city: Daejeon
country: Korea, Republic of
facility: Chungnam National University Hospital CNUH
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Incheon
country: Korea, Republic of
facility: The Catholic University of Korea, Incheon St. Mary's Hospital
city: Incheon
country: Korea, Republic of
facility: Inha University Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei Univ. Health System
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St. Mary's Hospital
city: Seoul
country: Korea, Republic of
facility: Chung-Ang University Hospital
city: Seoul
country: Korea, Republic of
facility: Hallym University Kangnam Sacred Heart Hospital
city: Riga
country: Latvia
facility: Riga 1st Hospital, Clinic of Dermatology and STD
city: Riga
country: Latvia
facility: Aesthetic dermatology clinic of Prof. J. Kisis
city: Riga
country: Latvia
facility: Health Centre 4 Ltd. Diagnostics Centre
city: Riga
country: Latvia
facility: Childrens Clinical University Hospital State SLLC
city: Riga
country: Latvia
facility: Health and Aesthetics Ltd
city: Riga
country: Latvia
facility: Health Centre 4 Ltd, Dermatology Clinics
city: Ventspils
country: Latvia
facility: Outpatient Clinic Of Ventspils
city: Del. Cuauhtemoc
country: Mexico
facility: Hospital Infantil de Mexico Federico Gomez
state: Ciudad DE Mexico
city: Saltillo
country: Mexico
facility: Clinical Research Institute S.C.
state: Coahuila
city: Cuernavaca
country: Mexico
facility: JM Research SC
state: Morelos
city: Monterrey
country: Mexico
facility: Centro de Dermatologia de Monterrey
state: Nuevo LEON
city: Merida
country: Mexico
facility: Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan
state: Yucatan
city: Mérida
country: Mexico
facility: Unidad de Atención Médica e Investigación en Salud
state: Yucatán
city: Aguascalientes
country: Mexico
facility: Derma Norte del Bajio S.C.
city: Chihuahua
country: Mexico
facility: Centro de Investigacion Integral MEDIVEST, S.C.
city: Chihuahua
country: Mexico
facility: Servicios Hospitalarios de Mexico S.A. de C.V. (Hospital Ángeles Chihuahua)
city: Cuautitlan Izcalli
country: Mexico
facility: Phylasis Clinicas Research S. de R.L. de C.V.
city: Mexico City
country: Mexico
facility: Hospital de Jesus, I.A.P.
city: Mexico City
country: Mexico
facility: Cryptex Investigación Clínica, S.A. de C.V.
city: Mexico city
country: Mexico
facility: Arke Estudios Clinicos Sa De Cv
city: Mexico City
country: Mexico
facility: Trials in Medicine S.C.
city: Monterrey
country: Mexico
facility: Eukarya Pharmasite S.C.
city: Queretaro
country: Mexico
facility: SMIQ, S. de R. L. de C.V.
city: Veracruz
country: Mexico
facility: Sociedad de Metabolismo y Corazon S.C.
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum (UMC) Utrecht
city: Bialystok
country: Poland
facility: NZOZ Specjalistyczny Osrodek Dermatologiczny DERMAL s.c.
city: Białystok
country: Poland
facility: KLIMED Marek Klimkiewicz
city: Bydgoszcz
country: Poland
facility: Clinica Dermatoestetica Prywatny Gabinet Dermatologiczny i Alergologiczny
city: Chorzow
country: Poland
facility: DERMAPOLIS Medical Dermatology Center dr n. med. Edyta Gębska
city: Czestochowa
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Czestochowie
city: Gdansk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne Klinika Dermatologii, Wenerologii i Alergologii
city: Gdansk
country: Poland
facility: Neutrum Lekarze M. Hlebowicz i Partnerzy Spolka Partnerska
city: Gdansk
country: Poland
facility: Szpital Sw. Wojciecha
city: Gdynia
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Gdyni
city: Grodzisk Mazowiecki
country: Poland
facility: MCBK
city: Katowice
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Katowicach
city: Katowice
country: Poland
facility: MULTIKLINIKA Salute Sp. z o.o.
city: Katowice
country: Poland
facility: Silmedic Sp. z o.o., Oddzial w Katowicach
city: Katowice
country: Poland
facility: Care Clinic Centrum Medyczne
city: Katowice
country: Poland
facility: Centrum Medyczne Angelius Provita
city: Katowice
country: Poland
facility: Pro Familia Altera Sp. z o.o.
city: Kielce
country: Poland
facility: Gabinet Dermatologiczny Beata Krecisz
city: Krakow
country: Poland
facility: Malopolskie Centrum Kliniczne
city: Krakow
country: Poland
facility: Centrum Badan Klinicznych JCI
city: Krakow
country: Poland
facility: Centrum Medyczne Plejady
city: Krakow
country: Poland
facility: Centrum Nowoczesnych Terapii "DOBRY LEKARZ" sp. z o.o.
city: Krakow
country: Poland
facility: AWP Klinika Dermatologii Pod Fortem Anna Wojas-Pelc
city: Krakow
country: Poland
facility: Centrum Medyczne Promed
city: Krakow
country: Poland
facility: Krakowskie Centrum Medyczne Sp. z o.o.
city: Ksawerow
country: Poland
facility: Prywatna Praktyka Lekarska - Adam Smialowski INTERMED KSAWEROW
city: Lodz
country: Poland
facility: NZOZ "DERMED" Centrum Medyczne Sp. z o.o. - Oddzial w Lodzi
city: Lodz
country: Poland
facility: Centrum Terapii Wspolczesnej J.M. Jasnorzewska Spolka Komandytowo-Akcyjna
city: Lodz
country: Poland
facility: Osrodek badan klinicznych AppleTree Clinics
city: Lodz
country: Poland
facility: Dermoklinika-Centrum Medyczne s.c. M. Kierstan, J. Narbutt, A. Lesiak
city: Lublin
country: Poland
facility: KO-MED Centra Kliniczne Lublin II
city: Lublin
country: Poland
facility: NZOZ "Med-Laser" Borzecki Spolka Jawna
city: Ostrowiec Swietokrzyski
country: Poland
facility: Dermedic Jacek Zdybski
city: Poznan
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Poznaniu
city: Poznan
country: Poland
facility: Clinical Research Center Sp. z o.o. MEDIC-R Sp. k.
city: Poznan
country: Poland
facility: Gabinety Lekarskie Rivermed
city: Rybnik
country: Poland
facility: LIFT-MED Spolka Akcyjna
city: Rzeszow
country: Poland
facility: Kliniczny Szpital Wojewodzki nr 1 im. F. Chopina, Klinika Dermatologii
city: Rzeszow
country: Poland
facility: EMED Centrum Uslug Medycznych Ewa Smialek
city: Szczecin
country: Poland
facility: Andrzej Krolicki, Tomasz Kochanowski "Laser Clinic" S.C.
city: Szczecin
country: Poland
facility: Twoja Przychodnia Szczecinskie Centrum Medyczne
city: Tarnow
country: Poland
facility: Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. z o.o.
city: Warszawa
country: Poland
facility: MICS Centrum Medyczne Warszawa
city: Warszawa
country: Poland
facility: Centrum Medyczne AMED
city: Warszawa
country: Poland
facility: MTZ Clinical Research Powered by Pratia
city: Warszawa
country: Poland
facility: Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji w Warszawie
city: Warszawa
country: Poland
facility: RCMed Oddzial Warszawa
city: Warszawa
country: Poland
facility: Carpe Diem Centrum Medycyny Estetycznej
city: Warszawa
country: Poland
facility: REUMATIKA - "Centrum Reumatologii" NZOZ 2
city: Warszawa
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Warszawie
city: Warszawa
country: Poland
facility: ETG Warszawa
city: Warszawa
country: Poland
facility: Klinika Ambroziak Sp. z o.o.
city: Warszawa
country: Poland
facility: Wojskowy Instytut Medyczny, Klinika Dermatologiczna
city: Wroclaw
country: Poland
facility: EMC Instytut Medyczny S.A. Przychodnia przy ul. Lowieckiej
city: Wroclaw
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial we Wroclawiu
city: Wroclaw
country: Poland
facility: Lukasz Matusiak "4Health"
city: Wroclaw
country: Poland
facility: Centrum Medyczne Oporow
city: Zabrze
country: Poland
facility: Kliniczny Oddzial Chorob Wewnetrznych, Dermatologii i Alergologii
city: Brasov
country: Romania
facility: SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL
state: JUD. Brasov
city: Cluj-Napoca
country: Romania
facility: Cabinet Medical de Dermatovenerologie Prof. Dr. Orasan Remus Ioan
state: Jud. Cluj
city: Bucharest
country: Romania
facility: SC Delta Health Care SRL
city: Chelyabinsk
country: Russian Federation
facility: SBIH "Chelyabinsk Regional Clinical Dermatovenerology dispensary"
city: Kemerovo
country: Russian Federation
facility: Limited Liability Company "Medical Center "Rheuma-Med"
city: Kirov
country: Russian Federation
facility: Clinic of FSBEI HE Kirov SMU MOH Russia
city: Moscow
country: Russian Federation
facility: FSBI "State Research Centre of Dermatovenereology and Cosmetology" MoH RF
city: Moscow
country: Russian Federation
facility: NRC Institute of Immunology FMBA of Russia
city: Rostov-on-Don
country: Russian Federation
facility: SBI RR "Skin and Venereal Dispensary"
city: Ryazan
country: Russian Federation
facility: SBI RR "Regional Clinical Skin and Veneral Dispensary"
city: Saint Petersburg
country: Russian Federation
facility: Limited Liability Company "Sanavita"
city: Saint-Petersburg
country: Russian Federation
facility: LLC "Pierre Wolkenstein Clinic of Skin Diseases"
city: Saint-Petersburg
country: Russian Federation
facility: Vitiligo center
city: Saint-Petersburg
country: Russian Federation
facility: FSBEI HE "St. Petersburg State Pediatric Medical University" MoH RF
city: Saint-Petersburg
country: Russian Federation
facility: "Medical Research Institute", LLC
city: Saint-Petersburg
country: Russian Federation
facility: FSBEI HE I.P.Pavlov SPbSMU MOH Russia
city: Smolensk
country: Russian Federation
facility: RSBIH "Smolensk Regional Clinical Hospital"
city: Belgrade
country: Serbia
facility: Military Medical Academy
city: Nis
country: Serbia
facility: Clinical Centre Nis
city: Pancevo
country: Serbia
facility: General Hospital Pancevo
city: Bratislava - Mestská Cast Nove Mesto
country: Slovakia
facility: Summit Clinical Research, s.r.o.
city: Bratislava- Mestská Časť Nové Mesto
country: Slovakia
facility: SKINKLINIK s.r.o.
city: Bratislava
country: Slovakia
facility: Narodny ustav detskych chorob
city: Bratislava
country: Slovakia
facility: BeneDerma s.r.o.
city: Bratislava
country: Slovakia
facility: Derma therapy spol. s.r.o, Dermatovenerologicka ambulancia
city: Kosice-Saca
country: Slovakia
facility: Nemocnica Kosice-Saca, a.s., 1. sukromna nemocnica, Kozna ambulancia
city: Nitra
country: Slovakia
facility: Derma-beauty, s.r.o., Dermatovenerologicka ambulancia
city: Nove Zamky
country: Slovakia
facility: Fakultna nemocnica s poliklinikou Nove Zamky, Dermatovenerologicka klinika
city: Svidnik
country: Slovakia
facility: SANARE spol.s.r.o.
city: Badalona
country: Spain
facility: Hospital Universitari Germans Trias i Pujol
state: Barcelona
city: Esplugues de Llobregat
country: Spain
facility: Hospital Sant Joan de Deu
state: Barcelona
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Universitario de Gran Canaria Dr. Negrin
state: LAS Palmas
city: Alcorcon
country: Spain
facility: Hospital Universitario Fundacion Alcorcon
state: Madrid
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro de Majadahonda
state: Madrid
city: Alicante
country: Spain
facility: Hospital General Universitario de Alicante
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau Servicio de Dermatologia
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia
city: Madrid
country: Spain
facility: Hospital Universitario de La Princesa
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Maranon
city: Madrid
country: Spain
facility: Hospital del Nino Jesus
city: Madrid
country: Spain
facility: Hospital Universitario 12 de octubre
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Pontevedra
country: Spain
facility: Centro de Especialidades Mollabao (Area Sanitaria de Pontevedra e O Salnes)
city: Pontevedra
country: Spain
facility: Hospital de Montecelo
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen de la Macarena
city: Valencia
country: Spain
facility: Consorcio Hospital General Universitario de Valencia
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
state: Taiwan (r.o.c)
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: New Taipei City
country: Taiwan
facility: Taipei Medical University-Shuang Ho Hospital
city: Taichung
country: Taiwan
facility: Chung Shan Medical University Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Tainan
country: Taiwan
facility: National Cheng-Kung University Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Mackay Memorial Hospital
city: Taoyuan City
country: Taiwan
facility: Chang Gung Memorial Hospital Linkou Branch
city: Wokingham
country: United Kingdom
facility: Medinova Research
state: Berkshire
city: Wokingham
country: United Kingdom
facility: MeDiNova West London Quality Research Sites
state: Berkshire
city: Plymouth
country: United Kingdom
facility: Plymouth Hospitals NHS Trust, Derriford Hospital
state: Devon
city: London
country: United Kingdom
facility: Royal free London NHS Foundation Trust
state: Greater London
city: Orpington
country: United Kingdom
facility: MeDiNova South London Quality Research Site
state: Kent
city: Northwood
country: United Kingdom
facility: Accellacare North London
state: Middlesex
city: Barnsley
country: United Kingdom
facility: Barnsley Hospital NHS Foundation Trust
state: South Yorkshire
city: Sheffield
country: United Kingdom
facility: Sheffield Children's NHS Foundation Trust
state: South Yorkshire
city: Sheffield
country: United Kingdom
facility: Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital
state: South Yorkshire
city: Blackpool
country: United Kingdom
facility: MAC Clinical Research
city: Bristol
country: United Kingdom
facility: University Hospital Bristol NHS Foundation Trust
city: Cannock
country: United Kingdom
facility: MAC Clinical Research
city: Coventry
country: United Kingdom
facility: Accellacare Warwickshire
city: Glasgow
country: United Kingdom
facility: West Glasgow Ambulatory Care Hospital
city: London
country: United Kingdom
facility: Guy's Hospital-Guy's and St Thomas NHS Foundation Trust
city: Manchester
country: United Kingdom
facility: MAC Clinical Research Ltd
city: Orpington
country: United Kingdom
facility: Accellacare South London
city: Shipley
country: United Kingdom
facility: Accellacare Yorkshire
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References:
citation: Simpson EL, Silverberg JI, Nosbaum A, Winthrop KL, Guttman-Yassky E, Hoffmeister KM, Egeberg A, Valdez H, Zhang M, Farooqui SA, Romero W, Thorpe AJ, Rojo R, Johnson S. Integrated Safety Analysis of Abrocitinib for the Treatment of Moderate-to-Severe Atopic Dermatitis From the Phase II and Phase III Clinical Trial Program. Am J Clin Dermatol. 2021 Sep;22(5):693-707. doi: 10.1007/s40257-021-00618-3. Epub 2021 Aug 18.