Clinical trial NCT03525392: Study to Evaluate the Safety and Activity (Including Distribution) of 177Lu-3BP-227 in Subjects With Solid Tumours Expressing Neurotensin Receptor Type 1.
Official title: An International Multicentre, Open-Label First in Human Phase I/II Study to Evaluate the Safety, Tolerability, Biodistribution and Antitumour Activity of 177Lu-3BP-227 for the Treatment of Subjects With Solid Tumours Expressing Neurotensin Receptor 1
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE1
Conditions: Pancreatic Ductal Adenocarcinoma
Colorectal Cancer
Gastric Cancer
Squamous Cell Carcinoma of the Head and Neck
Bone Cancer
Advanced Cancer
Recurrent Disease
Metastatic Tumours
Lead sponsor: Ipsen
Sponsor class: INDUSTRY
First posted: 2018-05-15
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study was conducted to advance new treatment for patients with metastatic or locally advanced cancers expressing Neurotensin receptor 1 (NTSR1). This study was the first time the investigational drug called 177Lu-3BP-227 was administered to patients under controlled conditions of a clinical study.

The purpose of this study was to evaluate how safe the investigational drug is as well to verify how well it is tolerated by patients after several intravenous administrations. In addition, the effect of the study drug on tumoral lesions and how it distributes throughout the body and at which rate it is removed from the body was evaluated. Since 177Lu-3BP-227 is a radio-labelled drug, it also measured how the emitted radiation is distributed throughout the body (dosimetry).

The study consisted of a phase I dose escalation part. The study originally planned to include a phase II study however due to early termination (not due to safety concerns) the study did not progress to phase II and was stopped during phase I. For the phase I dose escalation part, it was anticipated that approximately 30 subjects will be included, in up to six escalation steps. No expansion cohorts were implemented.


Eligibility criteria: Inclusion Criteria :

* Signed informed consent form prior to all study procedures
* Aged 18 years or older.
* Histologically or cytologically confirmed unresectable locally advanced or metastatic disease and has received prior lines of standard-of-care chemotherapy/treatment and has no further suitable treatment options and documented decision by a multidisciplinary oncology board including a specialist of the concerned pathology.
* Subjects have (a) pancreatic ductal adenocarcinoma (PDAC), or (b) colorectal adenocarcinoma (CRC), or (c) gastric adenocarcinoma (GC), or (d) gastrointestinal stromal tumours (GIST), or (e) squamous-cell carcinoma of head and neck (SCCHN), or (f) Ewing Sarcoma (ES)
* Tumour showing: (a) by uptake of 177Lu-3BP-227 (screening formulation) in known primary or metastatic sites as judged by the investigator to be greater than background; or (b) uptake of 111In 3BP 227 in known primary or metastatic sites (for subjects who participated in Study D FR 01087 002) as judged by the investigator to be greater than background.
* Measurable disease (based on RECIST version1.1).
* Documentation of progressive disease in the 6 months prior to study start (treatment).
* Eastern Cooperative Oncology Group performance status of 0 or 1 (unless if disability is related to surgery in ES and Agreed with the Sponsor).
* Adequate organ function as evidenced by: (a) Leukocytes ≥3000/μL (b) Absolute neutrophil count ≥1500/µL (c) Platelets ≥75,000/µL (d) Hb \>9 g/dL or \>10 g/dL (if history of cardiac disease) (e) Total serum bilirubin ≤2 times upper normal institutional limits (ULN) (f) Aspartate aminotransferase/alanine aminotransferase (ALT) ≤2.5×ULN (or ≤5×ULN, if subject has liver metastases) (g) Estimated glomerular filtration rate (eGFR) ≥55 mL/min.
* Estimated life expectancy \>3 months.
* Female subjects must not be pregnant or lactating at study entry and during the course of the study and must not become pregnant for at least 6 months following the last study treatment. Women of childbearing potential must agree to use a highly effective method of contraception
* For male subjects, must not father children during the study and for at least 6 months after the last study treatment and in addition must agree to use a condom for this period to protect his partner from contamination with the IMP. For males with partners who are of child bearing potential, effective contraception is a combination of male condom with either cap, diaphragm or sponge with spermicide (double barrier methods), but these are not considered to be highly effective. A man is considered to be infertile if he has had bilateral orchidectomy or successful vasectomy. Effective contraception includes a female partner of childbearing potential if she is using highly efficacious contraception, but the male subject must agree to use a condom to protect his partner as described above.
* Must be willing and able to comply with study restrictions and to remain at the clinic for the required time during the study period and willing to return to the clinic for the follow-up evaluation, as specified in the protocol.

Exclusion Criteria :

* Prior treatment received (a) Any antitumor treatment since last documented disease progression (b) Any chemotherapy within 3 weeks or nitrosourea within 6 weeks prior to first treatment investigational medicinal product (IMP) administration (c) Any curative radiotherapy within 4 weeks, or palliative radiotherapy within 7 days prior to first treatment IMP administration (d) Any monoclonal antibodies within 4 weeks or tyrosine kinases inhibitors within 2 weeks prior to the first treatment IMP administration, (e) Any other IMP within 2 weeks prior to first treatment IMP administration, if the previous compound is a mechanism-based molecularly targeted agent whose half-life (t1/2) is not well-characterized.
* Brain metastases.
* Nephrectomy, renal transplant or concomitant nephrotoxic therapy putting the subject at high risk of renal toxicity during the study.
* Only non-measurable metastatic bone lesions
* Existing or planned colostomy during study participation.
* Any history of inflammatory bowel disease.
* Any uncontrolled significant medical, psychiatric or surgical condition or laboratory finding, that would pose a risk to subject safety or interfere with study participation or interpretation of individual subject results.
* Clinically significant abnormalities on electrocardiogram (ECG) at screening including corrected QT interval (Fridericia's formula) \>450 msec for males or 470 msec for females at screening.
* Previously received external beam irradiation to a field that includes more than 30% of the bone marrow or kidneys.
* Any unresolved NCI-CTCAE Grade 2 or higher toxicity (except alopecia) from previous antitumor treatment and/or medical/surgical procedures/interventions.
* Known allergy to IMP or its excipients administered in this study, including imaging contrast media.
* Positive pregnancy test (female subjects).
* Likely to be uncompliant or uncooperative during the study, in the judgment of the investigator.
* Unable to understand the nature, scope, and possible consequences of the study, in the judgment of the investigator.
* Sponsor employees or investigator site personnel directly affiliated with this study, and their immediate families. Immediate family is defined as a spouse, parent, child or sibling, whether biological or legally adopted.

Primary outcomes:
measure: Phase 1: Number of Participants With Dose-Limiting Toxicities (DLT)
timeFrame: From the start of the first study medication (Cycle 1 Day 1) up to EOCT, maximum of 16 weeks.
Secondary outcomes:
measure: Phase 1: Maximum Uptake (%) of 177Lu-3BP-227 at Target Lesions and Discernible Organs
timeFrame: Measurements were performed at 0 to 1 hours, 2 to 4 hours, 16 to 24 hours, 40 to 48 hours, 72 to 96 hours post infusion in each treatment cycle.
measure: Phase 1: Maximal Concentration (Cmax) of 177Lu-3BP-227
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 24 hours, 48 hours and 72 to 96 hours post infusion in each treatment cycle.
measure: Phase 1: Time Post Injection to Achieve Cmax of 177Lu-3BP-227
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 24 hours, 48 hours and 72 to 96 hours post infusion in each treatment cycle.
measure: Phase 1: Area Under the Plasma Concentration Versus Time Curve (AUC) of 177Lu-3BP-227
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 24 hours, 48 hours and 72 to 96 hours post infusion in each treatment cycle.
measure: Phase 1: Half-life (t1/2) of 177Lu-3BP-227
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 24 hours, 48 hours and 72 to 96 hours post infusion in each treatment cycle.
measure: Phase 1: Number of Participants With Highest Absorbed Dose of 177Lu-3BP-227 to Each Discernible Organ
timeFrame: From the start of the first study medication (Day 1) up to EOCT, maximum of 16 weeks.
measure: Phase 1: Specific Absorbed Dose to the Target Lesions of 177Lu-3BP-227
timeFrame: From the start of the first study medication (Day 1) up to EOCT, maximum of 16 weeks.
measure: Phase 1: Specific Absorbed Dose Per Organ of 177Lu-3BP-227
timeFrame: From the start of the first study medication (Day 1) up to EOCT, maximum of 16 weeks.
measure: Phase 1: Cumulative Absorbed Organ Doses of 177Lu-3BP-227
timeFrame: From the start of the first study medication (Day 1) up to EOCT, maximum of 16 weeks.
measure: Phase 1: Cmax of 3BP-227
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 6 hours, 8 hours, 24 hours and 48 hours post infusion of 177Lu-3BP-227 in Cycle 1.
measure: Phase 1: AUC of 3BP-227
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 6 hours, 8 hours, 24 hours and 48 hours post infusion of 177Lu-3BP-227 in Cycle 1.
measure: Phase 1: t1/2 of 3BP-227
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 6 hours, 8 hours, 24 hours and 48 hours post infusion of 177Lu-3BP-227 in Cycle 1.
measure: Phase 1: Clearance of 3BP-227
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 6 hours, 8 hours, 24 hours and 48 hours post infusion of 177Lu-3BP-227 in Cycle 1.
measure: Phase 1: Volume of Distribution of 3BP-227
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 6 hours, 8 hours, 24 hours and 48 hours post infusion of 177Lu-3BP-227 in Cycle 1.
measure: Phase 1: Cumulative Amount of Unchanged 3BP-227 Excreted Into the Urine
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 6 hours, 8 hours, 24 hours and 48 hours post infusion of 177Lu-3BP-227 in Cycle 1.
measure: Phase 1: Renal Clearance of 3BP-227 From Plasma
timeFrame: Pre-infusion and at the end of infusion, and 5 minutes, 30 minutes, 90 minutes, 4 hours, 6 hours, 8 hours, 24 hours and 48 hours post infusion of 177Lu-3BP-227 in Cycle 1.
measure: Phase 1: Number of Participants With Objective Response Rate (ORR)
timeFrame: From the start of the first study medication (Day 1) up to EOCT, maximum of 16 weeks.
measure: Phase 1: Number of Participants With Disease Control Rate (DCR)
timeFrame: From the start of the first study medication (Day 1) up to EOCT, maximum of 16 weeks.
measure: Phase 1: Progression-Free Survival (PFS)
timeFrame: From the start of the first study medication (Day 1) up to EOCT, maximum of 16 weeks.
measure: Phase 1: Overall Survival (OS)
timeFrame: From the start of the first study medication (Day 1) up to EOCT, maximum of 16 weeks.
measure: Phase 1: Metabolic Tumor Response Using Positron Emission Tomography (PET) Response Criteria In Solid Tumors (PERCIST) Version 1.0 or Practical PERCIST
timeFrame: From the start of the first study medication (Day 1) up to EOCT, maximum of 16 weeks.
measure: Phase 1: Tumor Marker Levels in Serum - Cancer Antigen 19-9
timeFrame: Cycle 1 Day 1, Cycle 2 Day 1, EOCT (maximum of 16 weeks) and early withdrawal
measure: Phase 1: Tumor Marker Levels in Serum - Carcinoembryonic Antigen
timeFrame: Cycle 1 Day 1, Cycle 2 Day 1, EOCT (maximum of 16 weeks) and early withdrawal
Other outcomes:
Locations:
city: Houston
country: United States
facility: The University of Texas MD Anderson Cancer Center
state: Texas
city: Brussels
country: Belgium
facility: Institut Jules Bordet
city: Lyon
country: France
facility: Centre Léon Bérard
city: Marseille
country: France
facility: CHU Timone
city: Nantes
country: France
facility: CHU Hôtel Dieu
city: Groningen
country: Netherlands
facility: University Medical Center Groningen
city: Lausanne
country: Switzerland
facility: CHU Vaudois
city: Zürich
country: Switzerland
facility: Universitäts Spital Zürich
Study officials:
affiliation: Ipsen
name: Ipsen Medical Director
role: STUDY_DIRECTOR
References: