Clinical trial NCT01979029: Study of the Preservation of the Left Colic Artery on Rectum Cancer Surgery
Official title: Affection on Anastomotic Blood Flow and the Lymph Nodes Dissection Between Division at the Root of the Inferior Mesenteric Artery and Preserving the Left Colic Artery in Rectum Cancer Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Rectum Cancer
Lead sponsor: The First Hospital of Jilin University
Sponsor class: OTHER
First posted: 2013-11-08
Enrollment: 57
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the influence to the blood supply of the anastomosis and the harvest of the No. 253 lymph nodes in different surgical methods--- preserving the left colic artery (LCA) and resect the No. 253 lymph node specifically in the radical resection of rectal carcinoma or dividing at the root of the inferior mesenteric artery (IMA) in the radical resection of rectal carcinoma.

Detailed description: Methods: The patients who got rectal carcinoma are divided into two groups. Both groups will receive the radical resection of rectal carcinoma. We preserve the left colic artery and resect the No. 253 lymph node specifically in Group A and divide at the root of the inferior mesenteric artery in Group B, We insert a trocar into the arterial arcade at the proximal site of the anastomosis and measure the blood pressure of the arterial arcade in the operation, which can reflect the blood supply of the anastomosis. Besides, We will measure the length of the colon from the anastomosis to the level of the root of the IMA. Expecting Results：The blood pressure of the arterial arcade in Group A will be higher than that in Group B. And the patients in Group A will have less chance to get anastomotic fistula. Expecting Conclusions: Preserving the LCA and resecting the No. 253 lymph node specifically in the radical resection of rectal carcinoma can improve the blood supply of the anastomosis and decrease the incidence of anastomotic fistula, and won't affect the harvest of the No. 253 lymph node.

Eligibility criteria: Inclusion Criteria:

* Patients coming to FirstJilinU diagnosed rectum cancer by endoscopy and pathology.
* The rectum cancer is the first malignant neoplasm the patient has got.
* The cancer is solitary, and is 3cm to 20cm to the anus.
* The surgical method is limited to Dixon.

Exclusion Criteria:

* Being in the acute phase of inflammation before operation and emergency surgery.
* Patients receiving steroid medication or preoperative radiotherapy。
* Discovering macrometastasis before or in the operation.
* The rectum cancer that can't be radical resected.

Primary outcomes:
measure: The Blood Pressure of the Arterial Arcade
timeFrame: after ligating the inferior mesentric artery or superior rectal artery
Secondary outcomes:
measure: Distal Colon Length
timeFrame: after digestive tract reconstruction
Other outcomes:
measure: Systemic Blood Pressure
timeFrame: after ligating the inferior mesentric artery and measuring the blood pressure of the marginal artery of distal colon
Locations:
city: Changchun
country: China
facility: First Hospital of Jilin University
state: Jilin
Study officials:
affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
name: Jian Suo, Dr.
role: STUDY_CHAIR
References: