Clinical trial NCT04079725: Iris Tissue in Primary Congenital Glaucoma
Official title: Histopathological Examination of Iris Tissue in Primary Congenital Glaucoma
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Primary Congenital Glaucoma
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2019-09-06
Enrollment: 15
Sex: ALL
Minimum age (years): 7
Maximum age (years): 1
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To present the histopathological features of the iris tissue in primary congenital glaucoma which may play a role in pathogenesis

Detailed description: Primary congenital glaucoma etiology still remains obscure . originally barkan , and later Worst , proposed that a membrane covered the anterior chamber angle and blocked aqueous outflow , but the presence of that membrane has not been established histopathologically to date . Now most authors believe that the site of obstruction is the trabecular meshwork rather than an overlying membrane . Maldevelopment of the anterior segment is present in all forms of congenital glaucoma . this maldevelopment may involve the trabecular meshwork alone or the trabecular meshwork in combination with the iris or cornea or both. In approcimately 50% of patients , isolated trabeculodysgensis is the only developmental ocular anomaly found .This is the classic defect found in primary congenital glaucoma .These eyes have no developmental anomalies of iris or cornea present except abnormal insertion of the iris into the angle

Eligibility criteria: Inclusion Criteria:

1. Typical symptoms of epiphora , photophobia and blepharospasm
2. corneal diameter \> 13 mm
3. Increased ocular tension \> 25 mmHg UGA using schiotz tonometer

Exclusion Criteria:

1. Infants with history of previous surgery
2. Secondary glaucoma
3. Glaucoma associated with other congenital anomalies

Primary outcomes:
measure: Present histopathological features of iris tissue in infants with primary congenital glaucoma which may play a role in pathogenesis
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
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citation: Ocular Pathology Atlas. American Academy of Ophthalmology Web site. https://www.aao.org/resident-course/pathology-atlas. Published 2016. Accessed January 4, 2017
citation: American Academy of Ophthalmology. Congenital glaucoma, cloudy corneas. https://www.aao.org/image/congenital-glaucoma-cloudy-corneas-2 Accessed July 01, 2019