louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03757624: TISSUE SHRINKAGE DEPENDS ON FORMOL SOLUTION IN DIFFERENT GASTRIC LOCATIONS
Official title: TISSUE SHRINKAGE DEPENDS ON FORMOL SOLUTION IN DIFFERENT GASTRIC LOCATIONS
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Shrinking Stomach
Keywords: shrinkage
formol
stomach
gastric wall
Lead sponsor: Fatih Sultan Mehmet Training and Research Hospital
Sponsor class: OTHER
First posted: 2018-11-29
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Generally % 10 formol solution is use to do fixation to all specimens after the surgical operations for the pathological evaluation. It is known that the formol solution cause amount of shrinkage in the tissue volume . This effect of formol solution had researched in colon,breast and prostate previously. But there is no evidence about stomach. The purpose of this research is that find out the formol effect to the gastric tissue and detect the shrinkage percent.

Detailed description: All gastric specimens which removed after Laparoscopic Sleeve Gastrectomy will open from the major curvature and spread down to the table.in operating room..3 cm x 3 cm three tissue samples will collect from the specific locations. These three locations are ; fundus( 1 cm from the top of staple line) , corpus (middle of the major curvature , antrum ( 1 cm far from the bottom of staple line ). All these points 5 mm far from the major curvature. 6 samples will prepare totally. 2 samples for each location ; one mucosa and one all layer of gastric wall for each location .These 3 points will examine about wall thickness(mucosa- submucosa-muscularis propria -serosa ) After saving the measurements in operating room;the gastric specimen will deliver to a pathologist to put the specimen into the % 10 formol solution. After 24 hours ;pathologist will save all of new measurements same in operating room. The measurements of sample are ;height , length , width . After the completion of the measurements the investigator will compare the results found in operating room in fresh specimen with pathologist 's results after formol. After that the investigator will be able to decide the shrinkage of gastric tissue in % 10 formol solution.

Eligibility criteria: Inclusion Criteria:

* Patients older than 18 years old who will undergo to Laparoscopic Sleeve Gastrectomy

Exclusion Criteria:

* Patients who has to undergo another bariatric surgery type peroperatively
* Deformation of gastric specimen while removing from the abdomen

Primary outcomes:
measure: shrinkage in gastric tissue
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Fatih Sultan Mehmet Research and Training Hospital
Study officials:
References:
Clinical trial NCT00180024: Characterization of Vascular Effects of Angiotensin II in Dorsal Human Hand Veins.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Subjects
Keywords: AT1-receptor
AT2-receptor
human pharmacology
Lead sponsor: Technische Universität Dresden
Sponsor class: OTHER
First posted: 2005-09-16
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: ECT

Brief summary: The hypothesis is tested that stimulation with angiotensin II after blockade of the AT1-receptor results in venodilation in human healthy subjects in vivo.


Eligibility criteria: Inclusion Criteria:

* healthy subjects

Exclusion Criteria:

* any relevant disease

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Dresden
country: Germany
facility: Institute of Clinical Pharmacology, Medical Faculty, University of Technology
Study officials:
affiliation: Institute of Clinical Pharmacology
name: Wilhelm Kirch, MD
role: STUDY_CHAIR
References:
Clinical trial NCT02007824: Clinical Trial to Evaluate Ultrasonic Surgical Device in Chronic Pressure Ulcer
Official title: Clinical Trial to Evaluate Efficacy and Safety of Ultrasonic Surgical Device (ULSC-12D)in Chronic Pressure Ulcer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pressure Ulcer
Wound
Necrosis
Keywords: pressure ulcer
chronic wound
tissue necrosis
slough
ultra sound
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2013-12-11
Enrollment: 30
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Study objective The purpose of this trial is to evaluate the efficacy and safety of the investigational device, ULSD-12D, as Compared to the comparator, SONOCA-180, in chronic wound.

Detailed description: * Study design Multi-center, randomized clinical trial
* Study population Adults with chronic wound
* Investigational device treatment procedure Before Treatment: The subject's eligibility (inclusion/exclusion criteria) will be assessed,and apply the Study Device or Comparator on their wound in a randomized manner. Post-Treatment: All subjects will take pictures of the wound area and measured the number of microorganism and wound size.

Eligibility criteria: Inclusion Criteria:

* over 20 years of age
* subject who has untreated wounds
* subject who has wound size over 3cm x 3cm
* subject who has wound over stage 2

Exclusion Criteria:

* cellulitis

Primary outcomes:
measure: The number of microorganisms on wound bed
timeFrame: Baseline and 30minuts post debridement
Secondary outcomes:
measure: necrotic tissue region
timeFrame: Baseline and 30minuts post debridement
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
state: Gangnam-gu
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
city: Seoul
country: Korea, Republic of
facility: Hanyang University Hospital
state: Seongdong-gu
Study officials:
affiliation: Seoul National University Bundang Hospital
name: Chanyeong - Heo, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00502424: The Effectiveness of a Nighttime Positioning Hand Splint in Patients With Rheumatoid Arthritis
Official title: Study of the Effectiveness of a Positioning Hand Splint for Wrist, Fingers and Thumb in Patients With Arthritis Rheumatoid
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Rheumatoid Arthritis.
Keywords: Rheumatoid Arthritis
Hand
Splint
Occupational Therapy
Lead sponsor: Federal University of São Paulo
Sponsor class: OTHER
First posted: 2007-07-17
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the present study was to evaluate the effectiveness of a nighttime positioning hand splint in patients with RA in terms of pain, grip and pinch strength, upper limb function, quality of life, and patient satisfaction. The hypothesis is that the stabilization of hand during nighttime could decrease pain and consequently improve quality of life.

Detailed description: The involvment of wrist and fingers is very common in RA and it could affect hand function and, consequently, affect activities of daily living (ADL). Some authors suggest that the rest of hand could decrease pain and inflammation. Splints are external appliances that used in a specific body part provides the best alignment and rest in correct functional position. The goal of a hand, fingers and thumb in RA is stabilize the hand while the patients are not making theirs ADL and try to decrease the pain.

Eligibility criteria: Inclusion Criteria:

* Rheumatoid arthritis classified according to the ACR criteria.
* Use of the same remissive drugs for at least 6 months before the intervention and the same doses of the same corticosteroids and nonsteroidal anti-inflammatory drugs for at least one month before the study.
* A score ≥ 3 and ≤ 7 on a visual analog scale (VAS) for pain in the more aching hand.
* Agreement to participate in the study, and signing of a free informed consent form.

Exclusion Criteria:

* Presented deformities in the more aching hand that did not permit fabrication of the splint.
* Patients using any other type of upper limb splint.
* Patients with a surgery scheduled within 6 months after the study.
* Patients allergic to the splint material.
* Patients with mental deficiency.
* Patients who lived in inaccessible areas.

Primary outcomes:
measure: Pain using VAS at rest in cm, strength (grip and pinch), activities of daily living using HAQ questionnaire, hand function using DASH questionnaire and satisfaction with use by a likert scale of five points (much worst to much better).
timeFrame: Three months
Secondary outcomes:
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: UNIFESP - Federal University of Sao Paulo
Study officials:
affiliation: Federal University of São Paulo
name: Ana Carolina R Silva, student
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03323996: Impact of a Training in Therapeutic Education on the Relation Between Care Givers and Their Patients
Official title: Impact of a Training in Therapeutic Education on the Relation Between Care Givers and Their Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cancer of Liver
Diabetes
Lead sponsor: Centre Hospitalier Universitaire de Besancon
Sponsor class: OTHER
First posted: 2017-10-27
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Health professionnals attending a training in therapeuthic education and their patients.

Brief summary: This study aims to describe the impact of a training in therapeutic education on the relation between a caregiver and his/her patients.

Subjects are recruited among health professionals attending a training in therapeutic education. Then they are asked to identify up to 5 of their patients to be contacted by the researcher for an interview.

Individual semi-structured interviews are conducted with 20 duo "caregivers / patients" before the training, 1 month and 6 months after the training.


Eligibility criteria: Inclusion Criteria:

* Informed consent to participate to 3 interviews

Exclusion Criteria:

* Not fluent French speaker
* Patient under guardianship

Primary outcomes:
measure: Semi-Structured interviews
timeFrame: 9 months
Secondary outcomes:
Other outcomes:
Locations:
city: Besançon
country: France
facility: CHU de Besançon
Study officials:
References:
Clinical trial NCT06850896: Antibiotic Exposure on Gut Microbiota and Motility Establishment in Newborns
Official title: Effects of Early Antibiotic Exposure on Gut Microbiota and Motility Establishment in Newborns: a Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: NEC - Necrotizing Enterocolitis
Lead sponsor: The First Hospital of Jilin University
Sponsor class: OTHER
First posted: 2025-02-28
Enrollment: 200
Sex: ALL
Minimum age (years): 24
Maximum age (years): 36
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study will enroll newborns admitted to the neonatal unit of Jilin University First Hospital from November 2024 to November 2027.

Brief summary: This prospective cohort study aims to investigate the impact of early antibiotic exposure on the establishment of gut microbiota and motility in newborns, particularly preterm infants. The study will explore the correlation between antibiotic exposure, gut microbiota colonization, and 5-hydroxytryptamine (5-HT) levels, which are critical for gastrointestinal motility. The findings may provide insights into optimizing antibiotic use and improving gastrointestinal health in neonates.


Eligibility criteria: Inclusion Criteria:

* Newborns admitted within 72 hours of birth
* Gestational age 24-36 weeks (preterm) and term infants
* Informed consent obtained from parents or guardian

Exclusion Criteria:

* Congenital gastrointestinal malformations (e.g., intestinal atresia, Hirschsprung's disease)
* Severe systemic or organ-specific diseases
* Expected mortality due to severe illness

Primary outcomes:
measure: gut microbiota
timeFrame: Enrollment Period: This is the time during which participants will be recruited and enrolled into the study. You have specified that enrollment will occur from November 2024 to November 2027. Intervention Period: Since this is an observational study, the
Secondary outcomes:
Other outcomes:
Locations:
city: Changchun
country: China
facility: The first hospital of Jilin university
state: Jilin
Study officials:
References:
citation: Jiang S, Zhang L, Yan W, Li S, Han J, Zhou Q, Yang Y, Lee SK, Cao Y; REIN-EPIQ Study Group. Antibiotic Use in Neonatal Intensive Care Units in China: A Multicenter Cohort Study. J Pediatr. 2021 Dec;239:136-142.e4. doi: 10.1016/j.jpeds.2021.08.067. Epub 2021 Aug 28.
Clinical trial NCT00592696: TRIAD Project: Qualitative Study of Adolescent Depression and Smoking
Official title: TRIAD Project: Qualitative Study of Adolescent Depression and Smoking
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Adolescent - Emotional Problem
Smoking
Keywords: Adolescent depression
Adolescent smoking
Lead sponsor: Drexel University
Sponsor class: OTHER
Collaborators: name: Children's Hospital of Philadelphia
First posted: 2008-01-14
Enrollment: 30
Sex: ALL
Minimum age (years): 12
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adolescents ages 12-19 who live with their parental guardian who meet criteria for major depression and who smoke cigarettes.

Brief summary: It has been shown in the adult literature that smoking is related to depression and visa versa. Not much is known about how this relationship is started or if one perhaps leads to the other. We are performing 1 hour long interviews with adolescents ages 12-19 who meet criteria for major depression and who smoke. They are interviewed along with their parent. Questions center around their view of depression and their history of depression as well as questions around their smoking as well as the interrelationships between the two. Transcripts are made of the interview and are being analyzed for themes.


Eligibility criteria: Inclusion Criteria:

* 12-19 years old
* Major depression
* Smoke cigarettes
* Lives with parents
* No confidentiality issues related to smoking

Exclusion Criteria:

* Non English speaking
* Suicidal ideation
* Pregnant

Primary outcomes:
measure: To determine relationships that exist between smoking and depression in adolescents
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: St. Christopher's Hospital for Children
state: Pennsylvania
Study officials:
affiliation: Children's Hospital of Philadelphia
name: Don Schwarz, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Levy SA, Westin AM, Reamy AM, Reyner JC, Syed T, Diamond GS. Communication about smoking between depressed adolescents and their parents. Nicotine Tob Res. 2010 Mar;12(3):191-7. doi: 10.1093/ntr/ntp192. Epub 2010 Jan 6.
Clinical trial NCT06733896: SCM Muscle Released in Patients with Cervicogenic Headache
Official title: The Effectiveness of Sternocleidomastoid Muscle Pressure Points in Patients with Cervicogenic Headache
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cervicogenic Headache
Keywords: trigger points
sternocleidomastoid
headaches
Lead sponsor: Al-Zaytoonah University of Jordan
Sponsor class: OTHER
First posted: 2024-12-13
Enrollment: 52
Sex: ALL
Minimum age (years): 25
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Sternocleidomastoid syndrome is often characterized by referred pain in other areas. Like all muscles, the SCM can develop tight, and non-contracting bands called trigger points that can refer pain elsewhere. For the SCM, the trigger point referral areas are the eye and forehead, the back of the head (occiput), front of the neck, cheek, and side of the head. Trigger points can be treated by direct manual massage, dry needling, or platelet-poor plasma injection.

Detailed description: Cervicogenic headache is a specific type of headache that originates from the cervical spine and is typically chronic in nature. Diagnostic criteria for CGH have been established by the International Headache Society (IHS) and are cited extensively in the literature. Diagnosis of CGH through manual examination is a more recent practice. To our knowledge, no systematic review of manual diagnosis of CGH has been performed.

Eligibility criteria: Inclusion Criteria:

* History of CGH ≥ 3 months at Baseline 1, ≥5 days of CGH per month
* CGH intensity ≥3 (0-10 scale)
* Cervical spine dysfunction (cervical joint tenderness and/or restricted segmental motion)
* Clear temporal sequence linking the source of CGH to the neck: headache preceded by neck pain, stiffness, movement and/or awkward postures

Exclusion Criteria:

* Other headaches within one year of enrollment (e.g. migraine occurring on \>1 day per month in the last year, medication overuse, daily, cluster, temporomandibular joint dysfunction related headaches, sinus, posttraumatic, tumor and glaucoma related, occipital neuralgia, metabolic/toxic/substance abuse related).
* Spinal manipulative therapy, massage or exercise therapy for neck pain or headaches in the previous 3 months. Any other types of care by a licensed provider in the previous month for headaches or neck pain
* Contraindications to study treatments (e.g., inflammatory arthropathies, cervical instability, severe osteoporosis, vertigo, dizziness)
* Daily prescription or nonprescription pain medication; corticosteroid use in previous month
* Cancer in the past five years
* ear problem

Primary outcomes:
measure: cervical neck pain
timeFrame: 4 weeks
Secondary outcomes:
measure: biodex balance system
timeFrame: 4 weeks
measure: neck stability index
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Makka
country: Saudi Arabia
facility: Umm Al Qura University
Study officials:
References:
Clinical trial NCT03534596: Surgery for Adhesive Small Bowel Obstruction in a Defined Population: a Cohort Study
Official title: Surgery for Adhesive Small Bowel Obstruction in a Defined Population: a Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Adhesive Small Bowel Obstruction
Keywords: cohort
surgery
adhesive small bowel obstruction
Lead sponsor: Uppsala University
Sponsor class: OTHER
First posted: 2018-05-23
Enrollment: 402
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing surgery due to adhesive small bowel obstructions during the time period 2007 -2011.

Brief summary: A cohort study of patients operated for adhesive small bowel obstruction (SBO) during a five-year period

Detailed description: It is a population-based cohort study of patients operated for adhesive small bowel obstruction during a five-year period (2007-2012) in two Swedish neighboring regions. Patients were identified by a broad search of operation and ICD codes. Preoperative data as age, gender, co-morbidity, previous surgery was registered as well as mechanisms of obstruction and intraoperative data. Short and long-term complications were analyzed. Patients were followed to 31st January 2017 , last medical note or death.

Eligibility criteria: Inclusion Criteria:

* \> 18 years old
* Surgery for adhesive small bowel obstructions during the time period 2007-2011 in Uppsala County and Gävle County, Sweden

Exclusion Criteria:

None

Primary outcomes:
measure: Incidence of surgery for SBO
timeFrame: 1st January 2007 - 31st December 2011
Secondary outcomes:
measure: Short term surgical complications
timeFrame: From surgery until <30 days postoperatively
measure: Long term surgical complications
timeFrame: >30 days postoperatively until death or 31st of January, 2017
measure: Relationships between complications and pre- and intraoperative variables
timeFrame: From surgery until death or 31st of January, 2017
Other outcomes:
Locations:
Study officials:
affiliation: Region Uppsala
name: Urban Karlbom, MD PhD
role: STUDY_CHAIR
References:
citation: Sakari T, Christersson M, Karlbom U. Mechanisms of adhesive small bowel obstruction and outcome of surgery; a population-based study. BMC Surg. 2020 Apr 6;20(1):62. doi: 10.1186/s12893-020-00724-9.