Clinical trial NCT06172920: Comparison of Tramadol, Pethidine and Morphine in the Treatment of Pain After Thoracic Surgery
Official title: Comparison of the Analgesic Effects of Tramadol, Pethidine and Morphine Under Erector Spinae Plane (ESP) Block in the Treatment of Pain After Elective Thoracic Surgery
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE4
Conditions: Thoracic Diseases
Analgesia
Keywords: thoracic surgery
patient controlled analgesia
postoperative care unit
intensive care
Lead sponsor: Baskent University
Sponsor class: OTHER
First posted: 2023-12-15
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 3 groups of patients are received different type of analgesics
Primary purpose: TREATMENT

Brief summary: Comparison of analgesic effects of tramadol, aldolan and morphine under thoracic surgery

Detailed description: Thoracotomy is one of the most painful surgical procedures known, and severe pain is encountered in 21-67% of patients after thoracotomy. The most important causes of this pain arise from the bone structures of the thoracic wall, damage to the costal joint junctions, stretching of the ligaments, rib fractures, and damage to the intercostal nerve and major muscles. Another factor that causes pain after thoracotomy is the chest tubes placed in the thorax to provide drainage (1).

As a result of this pain caused by loss of tissue and pulmonary reserve, effective coughing and decreased chest expansion can lead to serious complications such as atelectasis, ventilation/perfusion mismatch, hypoxemia, immobilization, thromboembolism and infection. These complications are associated with increased morbidity and mortality in thoracic surgery (2).

Ensuring pain management in patients undergoing thoracotomy is important in terms of reducing postoperative complications, ensuring early mobilization and increasing patient comfort. Since there is no single source that causes pain after thoracotomy, pain must be controlled at all levels. For this reason, a multimodal approach using pharmacological and non-pharmacological techniques is preferred in analgesia after thoracotomy. This approach reduces drug side effects along with the consumption of analgesics. Opioids and nonsteroidal anti-inflammatory drugs are used in pharmacological analgesia.

In our study, the investigators aim to compare the effects of tramadol, pethidine and morphine using intravenous patient-controlled analgesia in the treatment of postoperative pain in elective thoracic surgery.

Eligibility criteria: Inclusion Criteria:

* Having non-urgent thoracic surgery
* over 18 years old
* Being in group I-III according to the American Society of Anesthesiologists (ASA) classification
* Not have allergies to the drugs to be used (volunteers with diseases that prevent the use of drugs will not be included in the study
* regardless of gender

Exclusion Criteria:

. Have allergies to the drugs to be used

Primary outcomes:
measure: The rate of drugs's analgesic effects
timeFrame: postoperative 24 hours
measure: Comparing hemodynamic effects
timeFrame: Intraoperatively, then postoperative 24 hours
measure: Comparing respiratory effects
timeFrame: postoperative 24 hours
Secondary outcomes:
measure: Adverse effects of analgesics
timeFrame: postoperative 24 hours
measure: surgeon satisfaction
timeFrame: Immediately after the surgery
measure: patient satisfaction
timeFrame: Postoperative 30th minute
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Baskent University Ankara Hospital
Study officials:
References: