Clinical trial NCT00728520: Trial With Azacitidine in Newly Diagnosed Acute Myelogenous Leukemia (AML) Veterans Administration (VA) Elderly Patients Not Eligible for Standard Induction Therapy
Official title: A Phase II Trial With Azacitidine Single Agent in Newly Diagnosed Acute Myelogenous Leukemia (AML) Veterans Administration (VA) Elderly Patients Who Are Ineligible for Standard Induction Therapy: A Department of Veterans Affairs Multi-Site Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Acute Myeloid Leukemia
Elderly
Keywords: Leukemia
Azacitidine
Untreated
Elderly
Lead sponsor: Kansas City Veteran Affairs Medical Center
Sponsor class: FED
First posted: 2008-08-06
Enrollment: 40
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The drug that will be used in this study is called Azacitidine. Azacitidine belongs to a group of drugs which may restore normal control in cancer cells by affecting the genes and proteins in the body. Azacitidine is approved by the FDA for the treatment of Myelodysplastic Syndrome (MDS), a pre-leukemic bone marrow disease. The purpose of this study is to find out what effect the drug Azacitidine has on Acute Myeloid Leukemia (AML) in elderly patients.

Detailed description: Prior to starting treatment individuals being considered for this study will be evaluated to determine if they are eligible to participate in the study. There are certain prestudy test that are required: physical exam, blood tests, ECG, chest x-ray, bone marrow aspirate and biopsy to confirm the diagnosis of AML.

Treatment regimen consists of Azacitidine IV/SQ on days 1-5 every 28 days. If the Azacitidine is given IV it will be given over 15-40 minutes. The treatment will be given for a minimum of 4 treatment cycles. Blood samples will be taken every week to monitor for side effects of the Azacitidine. A bone marrow aspirate will be done every 3-4 months to determine the response to the study drug or until the disease progresses. There is also a quality of life questionnaire that will be completed at the beginning of the study and every 4 weeks while on the study.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of AML
* Elderly patients with denovo AML or secondary AML evolving from MDS in patient \>/= 60 who decline chemotherapy or those who are not currently candidates for induction chemotherapy
* Stable WBC \<10 x 109 and not requiring hydroxyurea, chemotherapy or leukapheresis for \>4 weeks
* No corticosteroids, hydroxyurea, low-dose cytarabine, interferon, ir retinoids within 1 month
* No prior decitabine
* No valproic acid or other histone deacetylase inhibitor for at least 2 weeks
* No G-CSF, or GM-CSF or Erythropoetin within 1 month of study entry
* No investigational agents within 28 days
* ECOG performance status \</= 2 or KPS \>/= 60%
* Life expectancy \> 2 months
* Normal organ function = Total bilirubin \</= 1.5 x ULN, AST/ALT \</= 2.5 x ULN
* Creatinine within normal limits or creatinine clearance \>/= 60ml/min
* Signed informed consent

Exclusion Criteria:

* Patients with t(15;17) or M3-AML
* Patients who have had chemotherapy or radiotherapy within 4 weeks prior to study entry, or who have not recovered from adverse effects of agents administered earlier
* Patients with CNS involvement of AML
* History of allergic reactions attributed to Azacitidine or compounds of similar chemical used in this study
* Pregnancy
* Other serious medical or psychiatric illness which would limit survival to \< 3 months or prevent the granting of informed consent or lead to situations that would limit compliance with study requirements
* Known positive serology for HIV, HIV positive patients with anti-retroviral therapy are ineligible
* Active systemic bacterial, fungal or viral infection
* Patients with severe complications of the leukemia including but not limited to active infection, uncontrolled infection, pneumonia, hypoxia, and shock
* Patients with advanced hepatic tumors
* Patients with poor history of medical compliance
* Patients with known platelet refractoriness

Primary outcomes:
measure: overall response rates, duration of response, toxicities
timeFrame: Starting 4 weeks after treatment, during the entire study duration, and upon study completion
Secondary outcomes:
measure: leukemia free survival, overall survival, quality of life, assess biomarkers and predictive markers for Azacitidine responsiveness in elderly AML patients
timeFrame: During the entire duration of the study and after study completion
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: Kansas City Veterans Affairs Medical Center
state: Missouri
Study officials:
affiliation: Albert Einstein College of Medicine
name: Amit Verma, MD
role: PRINCIPAL_INVESTIGATOR
References: