louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04280120: Effect of Neural Mobilization in Bells Palsy: A Randomized Controlled Trial
Official title: Effect of Neural Mobilization in Bells Palsy: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bell Palsy
Lead sponsor: Majmaah University
Sponsor class: OTHER
First posted: 2020-02-21
Enrollment: 62
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The study will include a minimum of 60 participants visiting the investigator's outpatient department from 2020-2021. The equal allocation procedure will be used based on the admission of the cases.
Primary purpose: TREATMENT

Brief summary: Bells palsy is a sudden paralysis of half of the facial muscle. The BP is idiopathic and 70% responds well with drug therapy. There are many complementary therapies such as , tapping, electrical stimulation, and massage that adds to the recovery of condition. However, efficacy of neural mobilization in BP is not reported in the scientific literature.

Detailed description: Bells Palsy responds well with drug therapy such as prednisolone and antiviral drugs for the duration of 10-12 days. However, the administration of these drugs produce adverse side effect. Therapist use a number of techniques to maintain the physiological properties of facial muscles. However, adding a new technique would add to the arsenal of techniques available for the therapist. The research is intended to determine the effect of adding Neural mobilization in the recovery of Bells Palsy. A randomized controlled trail is intended to include 60 participants divided into two groups. Experimental group will receive Neural Mobilization with conservative treatment and control group will receive conservative treatment only.

Eligibility criteria: Inclusion Criteria:

* The first episode of Bell's palsy.
* Modified House-Brackmann scale III-IV.

Exclusion Criteria:

* Diabetic
* Recurrent Bells palsy
* facial palsy
* History of stroke
* Any cerebrovascular accident
* epilepsy

Primary outcomes:
measure: Sunnybrook facial assessment scale
timeFrame: 1 year
measure: Kinovea© tool for facial movement analysis
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Ghāziābād
country: India
facility: IAMR
state: UP
city: Meerut
country: India
facility: Faizan Kashoo
state: UP
Study officials:
References:
Clinical trial NCT04202120: Age Stereotype Priming and Social Participation
Official title: Age Stereotype Priming and Moderating Effects of Social Participation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Aging Well
Memory Loss
Keywords: Age stereotypes
episodic memory
social participation
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
First posted: 2019-12-17
Enrollment: 150
Sex: ALL
Minimum age (years): 55
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Memory performance is shown to be affected by age stereotypes among older adults. The purpose of the study is to examine the effects of age stereotype primes on episodic memory using priming intervention. The moderating effects of social participation is also examined.

Detailed description: All participants are community-dwelling older adults residing in Hong Kong. They are invited to review their social participation profile and given a brief psycho-education about memory.

They are then randomly allocated to one of the two following conditions. Participants are primed either with age stereotypes or non-age stereotypes words by implicit priming intervention in the context of a reaction task prior to the episodic memory tasks. Other measures such as demographic variables and social participation rate are collected by questionnaire during the delayed recall interval.

Eligibility criteria: Inclusion Criteria:

Indication of largely normal cognitive functioning as screened on the Montreal Cognitive Assessment (MoCA) with Hong Kong norms -

Exclusion Criteria:

Sensory deficits and evidence of cognitive impairment as screened on the Montreal Cognitive Assessment (MoCA) with Hong Kong norms

-

Primary outcomes:
measure: Hong Kong List Learning Test
timeFrame: Change from baseline through study completion, an average of 2 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Applied Social Sciences, Hong Kong Polytechnic University
Study officials:
affiliation: Dr (female)
name: Alma Au, PhD
role: STUDY_CHAIR
References:
citation: Au A, Chan AS, Chiu H. Verbal learning in Alzheimer's dementia. J Int Neuropsychol Soc. 2003 Mar;9(3):363-75. doi: 10.1017/S1355617703930025.
citation: Wong A, Yiu S, Nasreddine Z, Leung KT, Lau A, Soo YOY, Wong LK, Mok V. Validity and reliability of two alternate versions of the Montreal Cognitive Assessment (Hong Kong version) for screening of Mild Neurocognitive Disorder. PLoS One. 2018 May 23;13(5):e0196344. doi: 10.1371/journal.pone.0196344. eCollection 2018.
citation: Stein R, Blanchard-Fields F, Hertzog C. The effects of age-stereotype priming on the memory performance of older adults. Exp Aging Res. 2002 Apr-Jun;28(2):169-81. doi: 10.1080/03610730252800184.
citation: Chan SCY, Au AML, Lai SMK. The detrimental impacts of negative age stereotypes on the episodic memory of older adults: does social participation moderate the effects? BMC Geriatr. 2020 Nov 5;20(1):452. doi: 10.1186/s12877-020-01833-z.
Clinical trial NCT00114920: Twelve Week Safety and Efficacy Study With a Topical Gel to Treat Common Warts in Adults
Official title: A Three-Stage, Modified-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel for the Treatment of Common Warts in Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Warts
Keywords: Wart(s)
Adults
Common Wart(s)
Lead sponsor: Graceway Pharmaceuticals, LLC
Sponsor class: INDUSTRY
First posted: 2005-06-21
Enrollment: 88
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The primary purpose of this study is to evaluate the effectiveness in adults, of four different strengths of resiquimod gel applied to common wart(s) three times a week for twelve weeks.

A second purpose is to evaluate the safety of the drug.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of common warts
* Two forms of birth control

Exclusion Criteria:

* Pregnant or breast feeding
* Other types of wart(s), ie. plantar
* Currently participating in another clinical study
* Chronic viral hepatitis B or C

Primary outcomes:
measure: Clearance of treated common wart(s)
Secondary outcomes:
measure: Partial clearance of treated common wart(s)
measure: Wart recurrence
Other outcomes:
Locations:
city: Evansville
country: United States
facility: Welborn Clinic
state: Indiana
Study officials:
References:
Clinical trial NCT03215420: Comparison of 3 Methods to Diagnose Endolymphatic Hydrops in Meniere's Disease
Official title: Diagnostic Agreement of Electrophysiological Audiovestibular Examinations With Magnetic Resonance Imaging (MRI) of the Inner Ear in Revealing Endolymphatic Hydrops (EH) in Patients With Certain or Probable Meniere's Disease (MD)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Endolymphatic Hydrops
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2017-07-12
Enrollment: 41
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this study is to compare 3 methods for the diagnosis of endolymphatic hydrops (EH) in patients with Meniere's disease: MRI 3 Tesla (to visualise EH directly), and functional explorations, namely electrocochleography and dephasing of acoustic distortion products (which are modified by the EH).

The research hypothesis is that the examinations will show agreement in the diagnosis of EH, and that the results obtained (quantitative values) will vary in the same direction over time and during flares of MD.


Eligibility criteria: Inclusion Criteria:

* persons who have provided written consent
* persons aged 18 to 75 years
* persons with certain, probable or possible Meniere's disease according to the international classification AAO-HNS

Exclusion Criteria:

* persons without health insurance cover
* adults under guardianship
* persons with a history of hypersensitivity to the active substance or to one of the excipients of the contrast agent used for the MRI or to any gadolinium chelate
* pregnant or breast-feeding women
* severe acute or chronic kidney failure
* other identified causes of cochleo-vestibular syndromes
* Impossibility to follow-up or carry out any of the examinations necessary for the protocol

Primary outcomes:
measure: Number of patients for whom an endolymphatic hydrops was diagnosed by electrocochleography
timeFrame: day one
measure: Number of patients for whom an endolymphatic hydrops was diagnosed by (Dephasing) of acoustic distortion products
timeFrame: day one
measure: Number of patients for whom an endolymphatic hydrops was diagnosed by 3T MRI 3T
timeFrame: day one
Secondary outcomes:
Other outcomes:
Locations:
city: Dijon
country: France
facility: CHu Dijon Bourgogne
Study officials:
References:
Clinical trial NCT05389020: Immunisation Simulation Using the Real-size Infant Manikin in Medical Education
Official title: Immunisation Simulation Using the Real-size Infant Manikin in Medical Education
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Immunization Skills
Keywords: Simulation
Manikin
Immunization
Vaccination
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2022-05-24
Enrollment: 205
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This was a quasi-experimental study that comprised medical students in pediatric rotation at the Faculty of Medicine, Universitas Indonesia, Jakarta. The investigators determined students' knowledge and practice improvement through simulation by using the real-size infant's arm and leg manikins; and evaluate the confidence in immunization after the simulation.


Eligibility criteria: Inclusion Criteria:

* Medical students in paediatric rotation at the Faculty of Medicine, Universitas Indonesia, Jakarta
* Medical students who attended immunisation workshops

Exclusion Criteria:

* Students who refused to participate
* Students who did not attend the immunisation workshops

Primary outcomes:
measure: Knowledge pre- and post-test questionnaire
timeFrame: Seven weeks after the immunization course
measure: Practical skill score using rubric
timeFrame: Seven weeks after the immunization course
measure: Number of students who were confident by self assessment using Likert scale questionnaire
timeFrame: Seven weeks after the immunization course
measure: Students' feedback questionnaire
timeFrame: Seven weeks after the immunization course
Secondary outcomes:
Other outcomes:
Locations:
city: Jakarta Pusat
country: Indonesia
facility: Dr. Cipto Mangunkusumo Hospital
Study officials:
affiliation: Indonesia University
name: Hartono Gunardi, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04983420: Effects of Different Polyphenol-containing Beverages on the Immune System and on Muscular Growth Factors
Official title: Effects of Different Polyphenol-containing Beverages on the Immune System and on Muscular Growth Factors - a Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Food Sensitivity
Lead sponsor: Balgrist University Hospital
Sponsor class: OTHER
First posted: 2021-07-30
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: In this research project, the effect of different polyphenol-containing beverages with varying alcohol content of \< 0.4 vol% on immune function as well as muscular growth factors will be investigated


Eligibility criteria: Inclusion Criteria:

* Healthy
* Age 20 - 60 years
* Written informed consent

Exclusion Criteria:

* severe gastrointestinal disease or known malabsorption
* use of proton pump inhibitors
* malignancies
* rheumatoid diseases
* metabolic syndrome
* acute or chronic infections or inflammatory diseases
* use of medications or supplements to interfere with immune function
* alcohol and/or drug abuse or addiction
* dependent relationship with the project manager or his or her employees
* pregnancy or breastfeeding
* chronic illness or regular use of medication (except hormonal contraception)
* smoker

Primary outcomes:
measure: white blood cells
timeFrame: before beverage intake
measure: white blood cells
timeFrame: 60 minutes after intake
measure: white blood cells
timeFrame: 120 minutes after intake
measure: inflammatory markers in the blood
timeFrame: before beverage intake
measure: inflammatory markers in the blood
timeFrame: 60 minutes after intake
measure: inflammatory markers in the blood
timeFrame: 120 minutes after intake
measure: blood alcohol
timeFrame: before beverage intake
measure: blood alcohol
timeFrame: 60 minutes after intake
measure: blood alcohol
timeFrame: 120 minutes after intake
measure: white blood cells
timeFrame: after 14 days of daily intake
measure: inflammatory markers in the blood
timeFrame: after 14 days of daily intake
measure: blood alcohol
timeFrame: after 14 days of daily intake
measure: polyphenol in the urine
timeFrame: before beverage intake
measure: polyphenol in the urine
timeFrame: 120 minutes after intake
measure: polyphenol in the urine
timeFrame: after 14 days of daily intake
Secondary outcomes:
measure: dietary habit
timeFrame: before beverage intake and day 12-14 of beverage intake
measure: dietary habit
timeFrame: day 12-14 of beverage intake
measure: physical activity
timeFrame: before beverage intake
measure: physical activity
timeFrame: day 14 of beverage intake
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: Balgrist University Hospital
Study officials:
affiliation: Balgrist University Hospital
name: Johannes Scherr, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04729920: Home Use of Mechanical Insufflation/Exsufflation Devices in Neuromuscular Diseases
Official title: Predictors of Home Use of Mechanical Insufflation/Exsufflation Devices in Neuromuscular Patients: a Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neuromuscular Diseases
Keywords: Mechanical insufflation-exsufflation
Cough assistance
Lead sponsor: Centre Hospitalier Universitaire Vaudois
Sponsor class: OTHER
Collaborators: name: Ligue Pulmonaire Vaudoise
name: University Hospital, Geneva
First posted: 2021-01-29
Enrollment: 43
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult subjects with neuromuscular disease, with an active prescription of MI-E for more than 3 months

Brief summary: With this cross-sectional study of adult subjects with neuromuscular disease in the French-speaking part of Switzerland, we aim to explore MI-E adherence using self-report questionnaires and device data in order to identify the factors that influence the pattern of MI-E use and satisfaction with the treatment. Determining potential barriers to regular long-term home use of MI-E could help in identifying the patients who would benefit most from this therapy.


Eligibility criteria: Inclusion Criteria:

* Age over 18 years
* Diagnosis of neuromuscular disease
* Active prescription of MI-E for more than 3 months

Exclusion Criteria:

-Invasive airway

Primary outcomes:
measure: Adherence to MI-E (reported)
timeFrame: 12 months, or since treatment initiation (> 3 months)
measure: Adherence to MI-E (objective)
timeFrame: 12 months, or since treatment initiation (> 3 months)
Secondary outcomes:
measure: Satisfaction with the device
timeFrame: 12 months, or since treatment initiation (> 3 months)
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: Service de Pneumologie, CHUV
state: Vaud
Study officials:
References:
Clinical trial NCT04230720: Effect of Artificial Tears on Biometry
Official title: Impact of Lubrication With Artificial Tears on Biometry Measurements for Cataract Surgery
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Cataract
Keywords: biometry measurement
artificial tear
cataract surgery
Lead sponsor: Weill Medical College of Cornell University
Sponsor class: OTHER
First posted: 2020-01-18
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if measurements for cataract surgery are improved with use of additional lubrication with artificial tears. The research study is being done to optimize measurements and provide patients with the best visual outcomes after cataract surgery.


Eligibility criteria: Inclusion Criteria:

* Male or female ≥ 18 years of age
* Documentation of bilateral age-related senile cataracts diagnosis

Exclusion Criteria:

* Patients currently using regularly scheduled artificial tears. Patients with infrequent or irregular use of artificial tears may not be excluded from the study.
* Patients using contact lenses.
* Patients with any other surface pathology affecting corneal biometric measurements determined with slit-lamp examination or medical history.

Primary outcomes:
measure: Change in Baseline in Keratometry Values (K1 and K2)
timeFrame: Baseline, Day 14
measure: Change in Baseline in Axis of Astigmatism
timeFrame: Baseline, Day 14
Secondary outcomes:
measure: Change in Baseline Calculated Intraocular Lens Power
timeFrame: Baseline, Day 14
measure: Change in Keratometry Values (K1 and K2) in Ocular Surface Disease Subjects
timeFrame: Baseline, Day 14
measure: Change in Axis of Astigmatism in Ocular Surface Disease Subjects
timeFrame: Baseline, Day 14
Other outcomes:
Locations:
city: New York
country: United States
facility: Weill Cornell Ophthalmology
state: New York
Study officials:
affiliation: Weill Medical College of Cornell University
name: Ashley Brissette, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06555874: Evaluation of the MORENO Score for the Regulation
Official title: Evaluation of the MORENO Score for the Regulation of Secondary Transfers to the UAS-SMUR in Brest in Finistère in 2020
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: the Safety / Feasibility /MORENO Score/Regulation / Secondary Transfers / SAMU 29 / Current Practices
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2024-08-15
Enrollment: 1500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 120
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All adult patients having benefited from a transfer

Brief summary: The main objective of this work is therefore to evaluate the safety and feasibility of the MORENO score for the regulation of secondary transfers to the SAMU 29 compared to current practices.

Detailed description: Today, there is an increase in the number of secondary transfers and paramedical transport between the different hospitals in a territory. They have been promoted by the SFMU (French Society of Emergency Medicine) since 2012.

The sharp increase in the number of calls for SAMU regulation means that decisions must be made quickly and safely regarding transport requiring or not requiring a medical presence. The development of a decision support tool for the level of medicalisation of a transfer therefore seems necessary. However, there is currently no recommendation in France.

The MORENO score has already been used in a hospital in the Var, as well as in Spain and Greece. Prior validation of this score in our health territory is essential before setting up an operational procedure. Using a list of simple clinical items, this score enables us to assess whether or not it is necessary to medicalise a transfer.

Eligibility criteria: Inclusion Criteria:

* All adult patients having benefited from a transfer regulated by the SAMU 29 of adult patients on the Finistère territory over a predefined period of time

Exclusion Criteria:

* Pediatric patient transfers
* Maritime transfers
* Transfers for which the collected information does not allow to establish the MORENO score.
* Patients under judicial protection (guardianship, curatorship,..)
* Opposition

Primary outcomes:
measure: Evaluation of the concordance of the MORENO score for the regulation of secondary transfers at SAMU 29 and our current practices
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Brest
country: France
facility: Chu Brest
Study officials:
References:
Clinical trial NCT02641574: Relation Between Complication in Repeated Cesarean Sections, Newborn Outcome and Surgical Characteristics and Maternal Information
Official title: Relation Between Complication in Repeated Cesarean Sections Compared With Newborn Outcome,Surgical Characteristics and Maternal Information
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Women Who Had at Lease One Cesarean Section in the Past
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2015-12-29
Enrollment: 5000
Sex: FEMALE
Minimum age (years): 17
Maximum age (years): 50
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All women who underwent a cesarean section at Rambam Medical Center who had at least one cesarean section in the past

Brief summary: To examine the relation between complication in Repeated Cesarean Sections and Newborn Outcome compared to number of repeated cesarean section and reasonf or surgery and personal medical information to the mother


Eligibility criteria: Inclusion Criteria:

women who had at least one cesarean section -

Exclusion Criteria:

women that this was their first cesarean section

-

Primary outcomes:
measure: surgical complication compared to number of repeated cesarean sections
timeFrame: during the surgery
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: