Clinical trial NCT01219569: Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry
Official title: The Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Blindness
Keywords: blindness
ischemic optic neuropathy
Lead sponsor: Rutgers, The State University of New Jersey
Sponsor class: OTHER
First posted: 2010-10-13
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: subjects undergoing orthopedic surgery in the supine position

Brief summary: This is a study to focus on the feasibility of using a monitor which may signal loss of visual function intraoperatively.

Detailed description: The degree of a relative afferent pupillary defect (RAPD) has been correlated with the severity of an eye injury and has been shown to have prognostic significance as an indicator of retinal ischemia. Therefore light flashed evoked pupillometry (LFEP) may serve as a useful indicator of visual function. LFEP's are not known to be sensitive to anesthetics. We will measure LFEP's using different anesthetic techniques to see if there are measurable differences in the latency, amplitude and constriction velocity of the pupillary reflex. Prior to induction of anesthesia, pupillometer readings will be taken in the supine position in both eyes. The patient will be anesthetised using a standard induction technique. For maintenance of anesthesia a remifentanil infusion will be administered and supplemented by either propofol infusion (at 120 and 160 mcg/kg/min)or sevoflurane (at 1.5 and 2.5% end-tidal in random sequence. The patients will receive muscle relaxants as needed. Pupillometry readings will be taken in both eyes after induction, after steady maintenance has been achieved and every 10 minutes for 30 minutes at each drug dose.

Eligibility criteria: Inclusion Criteria:

* planned orthopedic surgery on the lower extremities and positioned on the back

Exclusion Criteria:

* recent bout of conjunctivitis or pink eye
* condition which inhibits the normal pupillary function of my eye

Primary outcomes:
measure: Measure the pupil response using different anesthetic techniques
timeFrame: pupillometry measurements will be taken in both eyes after induction of anesthesia
Secondary outcomes:
measure: Measure the pupil response using different anesthetic techniques
timeFrame: When steady maintenance of anesthesia drug is obtained measure pupillometry response at 10 min
measure: Measure the pupil response using different anesthetic techniques
timeFrame: When steady maintenance of anesthesia drug is obtaines measure pupillometry response at 20 minutes
measure: Measure the pupil response using different anesthetic technique
timeFrame: When steady maintenance of anesthesia drug is obtained measure pu[illometry response at 30 minutes.
Other outcomes:
Locations:
city: Newark
country: United States
facility: University Hospital
state: New Jersey
Study officials:
affiliation: Rutgers, The State University of New Jersey
name: Geordie P. Grant, MD
role: PRINCIPAL_INVESTIGATOR
References: