Clinical trial NCT00157287: A Cluster Randomized Trial to Improve Weaning and Extubation From Mechanical Ventilation in Community Hospitals
Official title: A Cluster Randomized Trial to Improve Weaning and Extubation From Mechanical Ventilation in Community Hospitals
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Respiration, Artificial
Lead sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sponsor class: OTHER
First posted: 2005-09-12
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Protocol directed weaning has been shown to reduce the duration of mechanical ventilation for patients admitted to the intensive care unit (ICU) of tertiary centres. However, this benefit has not previously been studied in a community hospital setting. We therefore sought to evaluate the impact of an evidence-based weaning guideline on the outcomes for patients receiving mechanical ventilation in the ICUs of community hospitals in a cluster randomized controlled trial involving 11 community hospitals.


Eligibility criteria: Inclusion Criteria:

* patients ventilated for more than 24 hours

Exclusion Criteria:

* patients less than 16 years of age patients who receive only non-invasive ventilation patients chronically ventilated at time of ICU admission patients who will not be candidates for weaning from ventilation at time of admission If withdrawl of life support is imminent at the point the patient has been ventilated for 24 hours

Primary outcomes:
measure: ICU length of stay
Secondary outcomes:
measure: duration of ventilation
measure: length of hospital stay
measure: complications (re-intubation within 48 hours, pneumonia within 48 hours)
measure: ICU mortality
measure: Hospital mortality
measure: ICU readmissions
measure: Qulaity of life
Other outcomes:
Locations:
city: Brampton
country: Canada
facility: William Osler Health Centre (Brampton)
state: Ontario
city: Brantford
country: Canada
facility: Brant Community Health Systems
state: Ontario
city: Burlington
country: Canada
facility: Joseph Brant Memorial Hospital
state: Ontario
city: Guelph
country: Canada
facility: Guelph General Hospital
state: Ontario
city: London
country: Canada
facility: St. Joseph's Health Care
state: Ontario
city: Mississauga
country: Canada
facility: Trillium Health Centre
state: Ontario
city: North Bay
country: Canada
facility: North Bay General Hospital
state: Ontario
city: Oshawa
country: Canada
facility: Lakeridge Health Corporation (Oshawa)
state: Ontario
city: Stratford
country: Canada
facility: Stratford General Hospital
state: Ontario
city: Toronto
country: Canada
facility: St. Joseph's Health Centre
state: Ontario
city: Windsor
country: Canada
facility: Hotel Dieu of St. Joseph
state: Ontario
Study officials:
affiliation: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
name: Ronald J Butler, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
name: Claudio Martin, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
name: Femida Gwadry-Sridhar, MSc
role: PRINCIPAL_INVESTIGATOR
References: