Clinical trial NCT06474481: Zanubrutinib and G-CHOP in Untreated Intermediate-high Risk Follicular Lymphoma
Official title: A Study of the Zanubrutinib With G-CHOP Regimens in the Frontline Treatment of Intermediate-high Risk Follicular Lymphoma
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE2
Conditions: FL
Keywords: Zanubrutinib
Intermediate-high risk Follicular Lymphoma
G-CHOP
Lead sponsor: Tianjin Medical University Cancer Institute and Hospital
Sponsor class: OTHER
First posted: 2024-06-25
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: :This is a an open-label, single-arm study to evaluate the efficacy and safety of zanubrutinib and G-CHOP in untreated Intermediate-high risk Follicular Lymphoma patients.


Eligibility criteria: Inclusion criteria.

1. Histologically confirmed CD20 positive (+) follicular lymphoma, grade 1, 2, or 3a
2. Have had no prior systemic treatment for lymphoma
3. Meeting Groupe d'Etude des Lymphomes Folliculaires (GELF) criteria for initiation of treatment
4. 18-75 years old.
5. ECOG Performance Status of 0-2 within 10 days prior to registration.
6. Stage II, III, or IV by Ann Arbor staging system.
7. defined as Intermediate-high risk by the follicular lymphoma international prognostic index (FLIPI) 1 or FLIPI 2.
8. Demonstrate adequate organ function as defined below; all screening labs to be obtained within 28 days prior to registration.

   * Hematological: WBC≥3.5×109/L, Platelets ≥ 75×109/L,Absolute Neutrophil Count (ANC) ≥ 1.0×109/L，Hemoglobin (Hgb) ≥ 80 g/L
   * Renal:Calculated creatinine clearance ≥ 50 mL/min
   * Hepatic:Bilirubin ≤ 1.5 × upper limit of normal (ULN), AST/ALT ≤ 2.5×ULN
9. Females of childbearing potential must be willing to abstain from vaginal intercourse or use an effective method(s) of contraception from the time of informed consent, during the study and for 6 months after the last dose of study drug(s). Males able to father a child must be willing to abstain from vaginal intercourse or to use an effective method(s) of contraception from initiation of treatment, during the study and for 3 months after the last dose of study drug(s). See the protocol.
10. Life expectancy ≥6 months
11. Sign (or their legally-acceptable representatives must sign) an informed consent document indicating that they understand the purpose of and procedures required for the study, including biomarkers, and are willing to participate in the study

Exclusion criteria:

1. Known active central nervous system lymphoma or leptomeningeal disease
2. Evidence of diffuse large B-cell transformation
3. Grade 3b FL
4. Concurrent malignancy or malignancy within the last 3 years (except for ductal breast cancer in situ, non-melanoma skin cancer, prostate cancer not requiring treatment, and cervical carcinoma in situ) whose natural history or treatment has the potential to interfere with the safety or efficacy assessment of the investigational regimen are not eligible for this trial
5. Known history of human immunodeficiency virus (HIV), or active hepatitis C Virus, or active hepatitis B Virus infection, or any uncontrolled active significant infection, including suspected or confirmed John Cunningham (JC) virus infection
6. Clinically significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of screening, or any class 3 (moderate) or class 4 (severe) cardiac disease as defined by the New York Heart Association functional classification. Or left ventricular ejection fraction \<50%;
7. Neuropathy ≥grade 2
8. Known history of human immunodeficiency virus (HIV), or active hepatitis C Virus, or active hepatitis B Virus infection, or any uncontrolled active significant infection
9. Known pneumonia associated with idiopathic pulmonary fibrosis, machine (for example, occlusive bronchiolitis), history of drug induced pneumonia, or screening during the chest computed tomography (CT) showed active pneumonia
10. Have serious neurological or psychiatric history, can't normal study, including dementia, epilepsy, severe depression and mania
11. Patients who were deemed by the investigator to be ineligible for enrollment

Primary outcomes:
measure: CR (complete response) rate after induction (4 or 6 Cycles) by investigator (INV)
timeFrame: From enrollment to the end of treatment at cycle 4 or 6 (each cycle is 28 days)
Secondary outcomes:
measure: Objective Response rate after induction by investigator (INV)
timeFrame: From enrollment to the end of end of treatment at cycle 4 or 6 (each cycle is 28 days)
measure: Overall survival (OS)
timeFrame: From the date of cycle 1, day 1 to the date of death regardless of cause, assessed up to 3 years
measure: Progression free survival (PFS)
timeFrame: From the date of cycle 1, day 1 to the date of death regardless of cause, assessed up to 3 years
Other outcomes:
Locations:
Study officials:
References: