Clinical trial NCT05158530: Effect of Exercise Training in Lung Cancer
Official title: Effect Of Exercise Training In Patients With Lung Cancer During Chemotherapy Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lung Cancer, Nonsmall Cell
Keywords: Nonsmall Cell Lung cancer, Chemotherapy, Exercise training
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2021-12-15
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To determine the effects of exercise training in patients with lung cancer during chemotherapy treatment. In currently accessible literature, majority studies, met-analysis, and systemic reviews are related to surgical procedures and post-op pulmonary Rehabilitation of patients with Lung cancer. In literature, Gap related to the control group was observed also. The current study aimed to fulfill this gap by planning a structured intervention plan for the control group as well. It will also add in literature the deficiency of oncology rehab for patients receiving chemotherapy only.

Detailed description: Literature suggested that a pulmonary rehabilitation program for patients with non-small cell lung cancer undergoing induction chemo-radiotherapy seems to improve respiratory function. It is particularly recommended for smokers and patients with respiratory impairment.

Eligibility criteria: Inclusion Criteria:

- Diagnosed patients of stage 1 and 2 Non-small cell lung carcinoma (NSCLC) including Adenocarcinoma \& squamous cell carcinoma The diagnosis was established within 6 wk prior to enrollment and was confirmed by histology.

Participants are undergoing lung cancer chemotherapy Participant has the willingness to participate in training WHO physical fitness scores 0-1 Able to perform 6-minute walk test (6MWT) at baseline

Exclusion Criteria:

* • Participant with history of trauma and surgery

  * Patients with lung disease other than lung cancer
  * Uncontrolled hypertension or unstable coronary artery disease.
  * Severe OA, bone or CNS metastases.
  * hemoglobin \<10 g/dL
  * Lower than 3,500 white blood cells per microliter of blood

Primary outcomes:
measure: 6 min walk test: Distance (meters)
timeFrame: 4 weeks
measure: Forced Expiratory Volume in 1 second (FEV1)
timeFrame: 4 weeks
measure: Forced vital Capacity (FVC)
timeFrame: 4 weeks
measure: Rate of perceived exertion (RPE)
timeFrame: 4 weeks
Secondary outcomes:
measure: Mindfulness
timeFrame: 4 weeks
measure: Hospital Anxiety and Depression
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Peshawar
country: Pakistan
facility: Institute of Radiotherapy and Nuclear Medicine
state: KPK
Study officials:
affiliation: Riphah International University
name: Mehwish Waseem, MSPT(CPPT)
role: PRINCIPAL_INVESTIGATOR
References:
citation: Davis KM, Kelly SP, Luta G, Tomko C, Miller AB, Taylor KL. The association of long-term treatment-related side effects with cancer-specific and general quality of life among prostate cancer survivors. Urology. 2014 Aug;84(2):300-6. doi: 10.1016/j.urology.2014.04.036. Epub 2014 Jun 26.
citation: Vainshelboim B, Fox BD, Saute M, Sagie A, Yehoshua L, Fuks L, Schneer S, Kramer MR. Limitations in exercise and functional capacity in long-term postpneumonectomy patients. J Cardiopulm Rehabil Prev. 2015 Jan-Feb;35(1):56-64. doi: 10.1097/HCR.0000000000000085.