Clinical trial NCT06236646: Effects of Thai Dance With Twenty-five Squares in Elderly With Mild Cognitive Impairment
Official title: Effects of Thai Dance With Twenty-five Squares on Cerebrovascular and Cognitive Function in Elderly With Mild Cognitive Impairment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mild Cognitive Impairment
Keywords: aerobic exercise
elderly
mild cognitive impairment
cerebrovascular
respiratory function
Lead sponsor: Chulalongkorn University
Sponsor class: OTHER
First posted: 2024-02-01
Enrollment: 40
Sex: ALL
Minimum age (years): 60
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study was to determine the effects of Thai dance with twenty-five squares on cerebrovascular and cognitive function in elderly with mild cognitive impairment

Detailed description: Twenty elderly with mild cognitive impairment aged 60 years and over were randomized into 2 groups: control group (CON; n=20) and Thai dance with twenty-five squares training group (TDT; n=20). Participants in CON group do their daily routine without receiving any training program, while those in TDT group completed receiving Thai dance with twenty-five squares training program three time a week for twelve week-long (60 minutes/time). The physiological data, cerebrovascular function, cognitive, respiratory function, health-related physical fitness, and Blood biochemistry variables were analyzed during the pre-test and post-tests. The dependent variables between pre-test and post-tests were analyzed by paired t-test. The variables between pre-test and post-test were analyzed by paired t-test. In addition, an independent t-test was used to compare the variables between groups. Statistical significance was defined as p \< .05.

Eligibility criteria: Inclusion Criteria:

* Elderly males and females aged 60-79 years who can lead normal daily lives. Individuals with mild cognitive impairment identified through the Montreal Cognitive Assessment (MoCA) with a score in the range of 17 - 25.
* Must be able to listen, speak, read, write, and understand the Thai language.
* Should not have diseases or abnormalities such as heart disease, eye complications caused by diabetes, uncontrolled high blood pressure, kidney complications caused by diabetes, and stroke.
* Must not have other respiratory diseases such as tuberculosis (Tuberculosis), asthma (Asthma), lung cancer (Lung cancer), emphysema (Emphysema), chronic obstructive pulmonary disease (COPD), etc.
* Must be a person not at risk of falling, determined through a test of the ability to walk and turn 3 meters within a time period of 7 - 15 seconds.
* Must not have received medication to treat dementia.
* Should not have received exercise training for more than 20 minutes at a time, 3 days/week, or more in the past 6 months before participating in the research.
* Should not have symptoms of mental disorders such as schizophrenia, bipolar disorder, or depression.
* Should have passed the pre-exercise readiness assessment (PAR-Q).
* Must be willing to participate in the research and sign the consent form to take part in the study.

Exclusion Criteria:

* A force majeure event, such as illness, that prevents participation in the research.
* Participation in less than 80% of the research sessions (must participate 29 times out of 36 times).
* Unwillingness to continue participating in the research.

Primary outcomes:
measure: Cerebrovascular reactivity
timeFrame: Change from baseline Cerebrovascular reactivity at 12 weeks.
measure: Intima-Media Thickness (IMT) test
timeFrame: Change from baseline Intima-Media Thickness (IMT) at 12 weeks.
measure: Brachial-ankle pulse wave velocity (baPWV)
timeFrame: Change from baseline Brachial-ankle pulse wave velocity (baPWV) at 12 weeks.
measure: Brain oxygen saturation levels
timeFrame: Change from baseline Brain oxygen saturation levels at 12 weeks.
measure: The Monreal Cognitive Assessment (MoCA-T)
timeFrame: Change from baseline MoCA-T scores at 12 weeks.
measure: The Mini-Mental State Examination Thai (MMSE-T)
timeFrame: Change from baseline MMSE-T scores at 12 weeks.
measure: The Trail Making Test B Thai modified (TMT-B)
timeFrame: Change from baseline TMT-B testing time at 12 weeks.
Secondary outcomes:
measure: Pulmonary function (Forced vital capacity; FVC)
timeFrame: Change from baseline FVC at 12 weeks.
measure: Pulmonary function (Forced Expiratory Volume in one second; FEV1)
timeFrame: Change from baseline FEV1 at 12 weeks.
measure: Pulmonary function (The ratio of the forced expiratory volume in the first one second to the forced vital capacity of the lungs; FEV1/FVC)
timeFrame: Change from baseline FEV1/FVC at 12 weeks.
measure: Pulmonary function (Maximal voluntary ventilation; MVV)
timeFrame: Change from baseline MVV at 12 weeks.
measure: Respiratory muscle strength
timeFrame: Change from baseline respiratory muscle strength at 12 weeks.
measure: The Chair Sit and Reach Test
timeFrame: Change from baseline The Chair Sit and Reach Test scores at 12 weeks.
measure: The Back Scratch test
timeFrame: Change from baseline The Back Scratch test scores at 12 weeks.
measure: The Time Up and Go test
timeFrame: Change from baseline The Time Up and Go test time at 12 weeks.
measure: The Chair Stand test
timeFrame: Change from baseline The Chair Stand test scores at 12 weeks.
measure: The Arm Curl test
timeFrame: Change from baseline The Arm Curl test scores at 12 weeks.
measure: The 2-Minute Step Test
timeFrame: Change from baseline The 2-Minute Step Test scores at 12 weeks.
measure: The 6-Minute Walk Test
timeFrame: Change from baseline The 6-Minute Walk Test scores at 12 weeks.
measure: Blood chemical data test
timeFrame: Change from baseline blood chemical data at 12 weeks.
Other outcomes:
Locations:
city: Pathum Wan
country: Thailand
facility: Faculty of Sports Science, Chulalongkorn University
state: Bangkok
city: Bangkok
country: Thailand
facility: Wannaporn Tongtako
Study officials:
affiliation: Chulalongkorn University
name: Wannaporn Tongtako, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Akazawa N, Tanahashi K, Kosaki K, Ra SG, Matsubara T, Choi Y, Zempo-Miyaki A, Maeda S. Aerobic exercise training enhances cerebrovascular pulsatility response to acute aerobic exercise in older adults. Physiol Rep. 2018 Apr;6(8):e13681. doi: 10.14814/phy2.13681.
citation: Bherer L. Cognitive plasticity in older adults: effects of cognitive training and physical exercise. Ann N Y Acad Sci. 2015 Mar;1337:1-6. doi: 10.1111/nyas.12682.
citation: Boyle PA, Buchman AS, Wilson RS, Leurgans SE, Bennett DA. Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc. 2010 Feb;58(2):248-55. doi: 10.1111/j.1532-5415.2009.02671.x. Epub 2010 Jan 8.
citation: Miller SM, Taylor-Piliae RE. Effects of Tai Chi on cognitive function in community-dwelling older adults: a review. Geriatr Nurs. 2014 Jan-Feb;35(1):9-19. doi: 10.1016/j.gerinurse.2013.10.013. Epub 2013 Oct 24.