louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03873948: Evaluation of Arginine in Periodontal and Cardiovascular Disease
Official title: Analysis of Serum and Salivary ADMA-Arginine Levels in Patients With Periodontal and Cardiovascular Diseases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Metabolic Disorder
Arginine; Hyperaminoaciduria
Lead sponsor: University of Messina
Sponsor class: OTHER
First posted: 2019-03-14
Enrollment: 141
Sex: ALL
Minimum age (years): 19
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Thus, for this study, 35 patients with CP, 36 patients with CHD, 35 patients with CP+CHD, and 35 healthy subjects will finally enrolled.

Brief summary: Asymmetric dimethylarginine (ADMA) plays a key role in endothelial function and may be a link for the known interaction of periodontitis and coronary heart disease (CHD). The investigators compared the impact of gingival health, periodontitis (CP), CHD or of both diseases (CP+CHD) on saliva and serum ADMA levels.

Detailed description: The aim of this study was to evaluate a possible association between both saliva and serum ADMA levels in patients with CP and with CHD and if the serum ADMA levels are mediated by serum CRP.

Eligibility criteria: Inclusion Criteria:

* Presence of at least 16 teeth
* CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm;
* Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
* Presence of ≥40% sites with bleeding on probing (BOP)

Exclusion Criteria:

* Intake of contraceptives
* Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
* Status of pregnancy or lactation
* Previous history of excessive drinking
* Allergy to local anaesthetic
* Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Primary outcomes:
measure: Clinical Attachment level
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Messina
country: Italy
facility: University of Messina
Study officials:
References:
Clinical trial NCT06899048: The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio
Official title: Residual Paralysis in the Post Anesthesia Care Unit: The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio. A Prospective Single-Center Open-Label Cohort Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Muscle Relaxants
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-03-27
Enrollment: 91
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who will be scheduled to undergo elective surgical procedures requiring the use of neuromuscular blocking drugs.

Brief summary: evaluate the degree of association, and the predictive accuracy of the REPS (as a predictive tool) compared with the TOFr as a quantitative assessment tool for (rNMB) in surgical patients in the early postoperative phase. The TOFr will be measured at 0, 15, 30, 45, and 60 min after extubation.


Eligibility criteria: Inclusion Criteria:

1. Age group 18-65 years old
2. Both genders
3. Patients with American Society of Anesthesiologist physical status classification of 1 or 2.

Exclusion Criteria:

1. Patients who are less than 18 years old or more than 65 years old.
2. Patients with planned scheduled recovery in the intensive care unit or if more than 10 minutes had elapsed since tracheal extubation until NMB monitoring at the PACU.
3. Patients on medications that interfere with muscle activity.
4. Known allergy to neuromuscular blocking agents.
5. Pregnancy or suspected pregnancy.
6. Neuro-muscular diseases.
7. Patients refusing to participate in the study.

Primary outcomes:
measure: correlation between residual neuromuscular block risk prediction score and train of four
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University Hospitals
Study officials:
References:
Clinical trial NCT06667648: Effect of Wet Cupping Versus Moderate Intensity Aerobic Exercise on Inflammatory Markers in Diabetic Patients
Official title: Effect of Wet Cupping Versus Moderate Intensity Aerobic Exercise on Inflammatory Markers in Diabetic Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetes
Keywords: diabetes, cupping, aerobic excercise
Lead sponsor: Deraya University
Sponsor class: OTHER
First posted: 2024-10-31
Enrollment: 60
Sex: ALL
Minimum age (years): 30
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Among all pro-inflammatory biomarkers, TNF-α first recognized to be involved in the pathenogenesis of insulin resistance, and glucose-related abnormalities that link to T2DM. TNF-α plays a vital role in the overall pathophysiology of insulin resistance especially in males with greater body mass index as compared to that in the females This trial aims to investigate the effect of wet cupping therapy versus moderate intensity aerobic exercise on inflammatory markers in diabetic patients

Detailed description: Cupping therapy is a traditional treatment used to create suction on the skin over a painful area or acupuncture point using a bamboo or glass cup. Aerobic exercise (also known as endurance activities, cardio, or cardio-respiratory exercise) is physical exercise of low to high intensity that depends primarily on the aerobic energy-generating process. Chronic inflammation, including elevated levels of interleukin 6 (IL-6), is associated with diabetes, cardiovascular disease, and chronic kidney disease, as well as related diseases such as nonalcoholic hepatosteatosis. Amongst other triggers, elevated IL-6 levels may arise due to excess adipose tissue and can cause, for example, aberrant glucose metabolism leading to diabetes and other manifestations of the ensuing glucotoxicity in many tissues and organs, including the vasculature and other parts of the heart and the kidneys, as well as in the liver. The purpose of this study was to investigate the effect of wet cupping therapy versus moderate-intensity aerobic exercise on inflammatory markers in diabetic patients.

Eligibility criteria: Inclusion Criteria:

* had diabetes more than 10 years ago
* body mass index of 25 to 29.9 Kg/m2

Exclusion Criteria:

* Hepatic diseases, Cancer patients, Renal failure patients, Orthopedic problems or fractures of extremities, hypertensive patients, and Neurological problems

Primary outcomes:
measure: interleukin 6 concentrations
timeFrame: 6 months
measure: blood sugar level mg/dl
timeFrame: 6 months
measure: tumor necrosis factor percent
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05846048: Marital Rape:Knowledge, Attitudes and Prevalence in Asample of Married Women in Sohag Governorate
Official title: Marital Rape:Knowledge, Attitudes and Prevalence in Asample of Married Women in Sohag Governorate
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Marital Rape Knowledge ,Attitudes and Prevalence
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2023-05-06
Enrollment: 200
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: married females in sohag governorate

Brief summary: this study aims at estimation of prevalence of marital rape attitudes and knowledge towards it using semi structured questionnaire

Detailed description: this study trying to estimate knowledge of married women in sohag about marital rape attitudes towards it the size of the problem psychological , mental ,physical health consequences if the problem deserve criminalization

Eligibility criteria: Inclusion Criteria:

* married or previously married females

Exclusion Criteria:

* mentally disabled or who with low IQ

Primary outcomes:
measure: attitudes to marital rape questionnaire
timeFrame: 6 months
Secondary outcomes:
measure: prevalence of marital rape questionnaire
timeFrame: 6 months
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Sohag University Hospital
Study officials:
References:
citation: Basile KC. Prevalence of wife rape and other intimate partner sexual coercion in a nationally representative sample of women. Violence Vict. 2002 Oct;17(5):511-24. doi: 10.1891/vivi.17.5.511.33717.
citation: Bergen RK, Bukovec P. Men and intimate partner rape: characteristics of men who sexually abuse their partner. J Interpers Violence. 2006 Oct;21(10):1375-84. doi: 10.1177/0886260506291652.
citation: Jackson AL. State contexts and the criminalization of marital rape across the United States. Soc Sci Res. 2015 May;51:290-306. doi: 10.1016/j.ssresearch.2014.10.001. Epub 2014 Oct 14.
Clinical trial NCT04660786: Intralesional Vitamin D in Alopecia Areata
Official title: Intralesional Vitamin D3 Injection in Treatment of Alopecia Areata: A Novel Approach
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Alopecia Areata
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2020-12-09
Enrollment: 40
Sex: ALL
Minimum age (years): 10
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the efficacy and safety of intralesional injection of vitamin D3 versus intralesional injection of corticosteroids in treatment of alopecia areata.

this will be carried out on 40 patients who attend hair outpatient clinic, department of dermatology, Faculty of medicine, Alexandria University, Egypt.

The patients will be randomly assigned into two groups (A and B), each group contains 20 patients. Patients will be blindly subjected to intralesional injection of triamcinolone acetonide (5mg/ml) using sterile saline for dilution every 4 weeks for 3 sessions (11,12) or intralesional injection of vitamin D (an aqueous preparation of cholecalciferol (Devarol® ampoule 200,000 IU/2 mL, Memphis, Egypt) (2.5 mg/mL) every 4 weeks for 3 sessions. The maximum total amount of vitamin D3 injected into a patient in 1 session will be 5 mg Injection will be preceded by topical anaesthesia under occlusion for 30 minutes.


Eligibility criteria: Inclusion Criteria:

Site: scalp. Extent: localized alopecia areata (less than 50% scalp involvement).

Exclusion Criteria:

1. Other skin diseases affecting the scalp
2. Pregnant or lactating women.
3. Bleeding or coagulation disorders
4. Immunocompromised patients.
5. Known hypersensitivity to vitamin D3.
6. Patients who received systemic or topical treatment for alopecia areata in the last month.
7. Patients taking vitamin D supplements in the last 6 months.
8. Patients treated with topical vitamin D analogues.
9. Patients with diseases known to alter vitamin D level as autoimmune diseases, liver or renal diseases.
10. Obesity (defined as body mass index ≥ 25).

Primary outcomes:
measure: Regrowth Score (RGS)
timeFrame: three month
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Faculty of Medicine
Study officials:
References:
Clinical trial NCT01881386: Lactate Imaging as a Tumour Biomarker
Official title: Investigation of Lactate Measured Using Magnetic Resonance Spectroscopy as a Biomarker of Tumour Response
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cancer
Keywords: Magnetic Resonance Spectroscopy
Lactate
Lead sponsor: Institute of Cancer Research, United Kingdom
Sponsor class: OTHER
Collaborators: name: Cancer Research UK
First posted: 2013-06-19
Enrollment: 37
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Primary care clinic

Brief summary: This project is designed to investigate whether measurements of lactate in tumours, made using a magnetic resonance technique similar to MRI, is an effective non-invasive method to detect whether some new targeted drugs are having their desired effect.

The study hypothesis is that by using magnetic resonance spectroscopy techniques, we will be able to observe changes in tumour lactate levels in vivo, in response to treatment.


Eligibility criteria: Inclusion Criteria:

Cohort 1:lymphoma patients

* minimum lesion size of 2cm
* not pretreated but scheduled to be treated with CHOP (Cyclophosphamide, Hydroxydaunomycin,Oncovin and Prednisolone)

Cohort 2:Colorectal patients

* metastatic disease of at least 2cm
* not pretreated

Cohort 3:Phase 1 Drug Development

* minimum lesion size at least 2cm

Cohort 4: Brain

* primary brain tumours receiving radiotherapy and temozolomide
* cerebral lymphoma receiving standard chemotherapy

Exclusion Criteria:

* MRI incompatible metal implants
* Claustrophobia
* Inability to tolerate a 40 minute MRI scan

Primary outcomes:
measure: Correlation between changes in MRS lactate measurements at two time points after treatment and clinical response
timeFrame: 7 and 21 days post treatment
Secondary outcomes:
measure: Reproducibility of MRS lactate measurement
timeFrame: Two baseline measurements taken at day -7 to 0 pre-treatment
Other outcomes:
measure: Correlation between changes in post treatment MRS lactate measurements and serum lactate dehydrogenase
timeFrame: Baseline and 7 and 21 days post treatment
Locations:
city: Sutton
country: United Kingdom
facility: The Institute of Cancer Research and Royal Marsden NHS Foundation Trust
state: Surrey
Study officials:
affiliation: ICR
name: Nandita deSouza, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00395486: ROMEO (Rosuvastatin in Metabolic syndrOme)
Official title: A 6-week, Randomised, Open-label, Parallel Group, Multi-centre Study to Compare the Efficacy of Rosuvastatin 10mg With Atorvastatin 10mg in the Treatment of Metabolic Syndrome Subjects With Raised LDL-C
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Metabolic Syndrome X
Keywords: rosuvastatin
lipoprotein
metabolic syndrome
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2006-11-03
Enrollment: 258
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary objective of this study is to compare the effect of rosuvastatin 10mg with atorvastatin 10mg after 6 weeks of treatment in the ratio of ApoB/ApoA1 in subjects with metabolic syndrome.


Eligibility criteria: Inclusion Criteria:

* Presence of 3 or more of the following criteria;

  * Abdominal obesity (men \>90cm women \>80cm)
  * Triglycerides ≥ 150 mg/dL
  * HDL-C: men \< 40 mg/dL, women \< 50 mg/dL
  * BP ≥130/≥85 mmHg or anti-hypertensive treatment
  * Fasting blood glucose ≥100 mg dL or anti-diabetic treatment
* Elevated LDL-C ;

  * ≥130 mg/dL to \< 220 mg/dL in lipid lowering agent naive subjects
  * ≥100 mg/dL to \< 200 mg/dL in subjects who have taken a lipid lowering drug(s) within 4 weeks of visit 1.
* Triglyceride \< 500 mg/dL

Primary outcomes:
measure: Percentage Change From Baseline in Ratio of Apolipoprotein (ApoB/ApoA1) at Week 6
timeFrame: Baseline and 6 weeks
Secondary outcomes:
measure: Percentage of Subjects Reaching Their LDL-C Target Goal
timeFrame: Baseline and 6 weeks
measure: Percentage of Subjects Reaching Their Low-Density Lipoprotein-C (LDL-C) and Non High-Density Lipoprotein-C (HDL-C) Target Goal
timeFrame: Baseline and 6 weeks
measure: Percentage Change of Glucose Level
timeFrame: Baseline and 6 weeks
measure: Percentage Change of Insulin Resistance Using HOMA-R
timeFrame: Baseline and 6 weeks
measure: Percentage Change of Insulin Resistance Using QUICKI
timeFrame: Baseline and 6 weeks
measure: Percentage Reduction of Low-Density Lipoprotein-C (LDL-C)
timeFrame: Baseline and 6 weeks
measure: Percentage Change of Total Cholesterol (TC)
timeFrame: Baseline and 6 weeks
measure: Percentage Change of High-Density Lipoprotein-C (HDL-C)
timeFrame: Baseline and 6 weeks
measure: Percentage Change of Triglycerides (TG)
timeFrame: Baseline and 6 weeks
measure: Percentage Change of Apolipoprotein A1 (ApoA1)
timeFrame: Baseline and 6 weeks
measure: Percentage Change of Apolipoprotein B (ApoB)
timeFrame: Baseline and 6 weeks
Other outcomes:
Locations:
city: Pusan
country: Korea, Republic of
facility: Research Site
city: Seoul
country: Korea, Republic of
facility: Research Site
city: Suwon
country: Korea, Republic of
facility: Research Site
Study officials:
affiliation: AstraZeneca
name: JoonWoo Bahn, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05993286: Treatment of Misophonia: Comparison of Exposure and Sound Therapy
Official title: Treatment of Misophonia: Comparison of Exposure and Sound Therapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Misophonia
Keywords: Misophonia
sound therapy
exposure
psychoeducation
treatment
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2023-08-15
Enrollment: 76
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants were randomly assigned to one of three groups: psychoeducation only (the active control group), exposure therapy with psychoeducation, and sound therapy with psychoeducation. All participants were assessed at baseline, and then at 3rd and 6th weeks. All of them received psychoeducation at study intake. A random one third received no further active treatment, one third received exposure, and one third received sound therapy.
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to compare the effects of possible treatments in misophonics. The main question it aims to answer is:

- Is exposure more effective on misophonic symptoms than sound therapy? Participants are randomly assinged to three groups of treatment;

1. Psychoeducation
2. Psychoeducation + Exposure
3. Psychoeducation + Sound Therapy


Eligibility criteria: Inclusion Criteria:

* People have Misophonia

Exclusion Criteria:

* Current psychosis
* Mental retardation or dementia
* those who had previously received exposure or sound therapy for misophonia symptoms.

Primary outcomes:
measure: The mean change in Misophonia Total Score (MTS)
timeFrame: Week 0 and Week 6
measure: The "improvement"
timeFrame: Week 3 and Week 6
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University Department of Psychiatry
Study officials:
affiliation: Hacettepe University
name: Cengiz Kılıç, Prof.
role: STUDY_DIRECTOR
References:
citation: Swedo SE, Baguley DM, Denys D, Dixon LJ, Erfanian M, Fioretti A, Jastreboff PJ, Kumar S, Rosenthal MZ, Rouw R, Schiller D, Simner J, Storch EA, Taylor S, Werff KRV, Altimus CM, Raver SM. Consensus Definition of Misophonia: A Delphi Study. Front Neurosci. 2022 Mar 17;16:841816. doi: 10.3389/fnins.2022.841816. eCollection 2022.
citation: Kilic C, Oz G, Avanoglu KB, Aksoy S. The prevalence and characteristics of misophonia in Ankara, Turkey: population-based study. BJPsych Open. 2021 Aug 6;7(5):e144. doi: 10.1192/bjo.2021.978.
citation: Jager IJ, Vulink NCC, Bergfeld IO, van Loon AJJM, Denys DAJP. Cognitive behavioral therapy for misophonia: A randomized clinical trial. Depress Anxiety. 2020 Dec 18;38(7):708-18. doi: 10.1002/da.23127. Online ahead of print.
Clinical trial NCT00892086: Prevalence and Recognition of Geriatric Syndrome in Outpatient Clinic at Srinagarind Hospital
Official title: Prevalence and Recognition of Geriatric Syndrome in Outpatient Clinic at Srinagarind Hospital
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Dementia
Cognitive Impairment
Depression
Urinary Incontinence
Constipation
Falls
Keywords: geriatric syndrome
immobility
Lead sponsor: Khon Kaen University
Sponsor class: OTHER
First posted: 2009-05-04
Enrollment: 50
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: internal medicine outpatient clinic

Brief summary: The purpose of this study is to collect the prevalence of geriatric syndrome, which is recognized by an internist, and to compare the data based on the comprehensive geriatric assessment by a geriatrician. The secondary outcome is to develop a practical collected form for the internist.


Eligibility criteria: Inclusion Criteria:

* all patients who are over than 60 years old who visit internal medicine outpatient clinic

Primary outcomes:
measure: Comparing the prevalence of geriatric syndrome between internist and geriatrician
timeFrame: 1 year
Secondary outcomes:
measure: Development of a practical form to collect patient's data
timeFrame: 1 year
Other outcomes:
Locations:
city: Muang district
country: Thailand
facility: Srinagarind hospital, Khon Kaen university
state: Khon Kaen
Study officials:
References: