Clinical trial NCT02925572: Teenagers: Impact of Eccentric eXercise Training on Overweight and Obesity
Official title: Impact of Muscular Training Program on Body Composition of Overweight and Obese Teenagers: classi201c Cycling Exercise in Concentric Versus Eccentric
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Adolescents (12 to 17 Years Old)
Obese (BMI>90th Percentile)
Keywords: pediatric obesity
eccentric exercise
body composition
training program
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
Collaborators: name: ONAPS : Observatoire National de l'Activité Physique et de la Sédentarité
First posted: 2016-10-06
Enrollment: 40
Sex: ALL
Minimum age (years): 12
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle which permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.

The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).

This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2.. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition.

Detailed description: 40 obese adolescents will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2 weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric and isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Eligibility criteria: Inclusion Criteria:

* Adolescent (12 to 17 years old)
* BMI\>90th percentile
* Post puberty (Tanner 3 to 5)
* Inactive (\<10 METS/h/week)
* No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no genetic obesity and no contraindication to physical activity

Exclusion Criteria:

-

Primary outcomes:
measure: change in total body fat mass (Dual X ray Absorptiometry)
timeFrame: before and after the 12 weeks training program
Secondary outcomes:
measure: aerobic capacities (VO2max)
timeFrame: before and after the 12 weeks training program
measure: isometric muscular lower limbs strength
timeFrame: before and after the 12 weeks training program
measure: isokinetic muscular lower limbs strength
timeFrame: before and after the 12 weeks training program
measure: rest energy expenditure (indirect calorimetry)
timeFrame: before and after the 12 weeks training program
measure: biological parameters (plasma lipid profile and insulin-resistance )
timeFrame: before and after the 12 weeks training program
measure: physical activity (actimetry and questionnaires)
timeFrame: before and after the 12 weeks training program
measure: food intakes (measurements and questionnaires)
timeFrame: before and after the 12 weeks training program
measure: quality of life (questionnaires)
timeFrame: before and after the 12 weeks training program
measure: segmental body composition (segmental fat and fat free mass, Dual X-ray Absorptiometry)
timeFrame: before and after the 12 weeks training program
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Valérie JULIAN
role: PRINCIPAL_INVESTIGATOR
References:
citation: Julian V, Thivel D, Miguet M, Brengues C, Pereira B, Courteix D, Richard R, Duclos M. Bone response to eccentric versus concentric cycling in adolescents with obesity. Obes Res Clin Pract. 2020 Nov-Dec;14(6):554-560. doi: 10.1016/j.orcp.2020.10.002. Epub 2020 Oct 26.