louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02120495: Application of Digital Techniques in Intraoral Condylectomy Via Coronoid Process Resection
Official title: Application of Digital Techniques in Intraoral Condylectomy Via Coronoid Process Resection
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Surgical Approach & Incisions
Keywords: condylectomy
TMJ function
intraoral approach
Lead sponsor: Peking University
Sponsor class: OTHER
Collaborators: name: Beijing Municipal Science & Technology Commission
First posted: 2014-04-22
Enrollment: 21
Sex: ALL
Minimum age (years): 15
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study will apply the digital techniques to do the condylectomy through an intraoral approach without needing to do the intraoral vertical ramus osteotomy (IVRO). This new surgical technique will greatly maintain the TMJ anatomy structure, reduce the risk and increase the precision of the operation procedure.

Detailed description: In this study we will use the digital techniques such as pre-surgical visual treatment planning, real time surgical navigation system, endoscope techniques, to do the intraoral condylectomy via coronoid process resection. After the condyle lesion resection, the coronoid process will be reimplanted and fixed by stainless steel wire. By using these techniques we can safely and precisely cut proper size and position of the condyle lesion as we pre-surgically designed, and at the same time greatly maintain the temporomandibular joint anatomy structure. Since we don't need to do the mandible vertical ramus osteotomy, and no conventional extraoral incision will be needed, the surgical injury will be minimized and the TMJ function will recover soon postoperatively. Additionally, the intraoral approach can avoid the risk of facial nerve injury, salivary fistula and skin scar, so it has better aesthetic results than the preauricular approach and the submandibular approach.

Eligibility criteria: Inclusion Criteria:

* Patients with mandible condylar hyperplasia or osteoma who need to do the condylectomy to prevent the active growth of the affected mandible condyle and the consequence progressive facial asymmetry
* Usually the patients have TMJ functional disorder; and the SPECT shows difference greater than 20% (pixel count) between the affected side and the contralateral normal side.

Exclusion Criteria:

* Patients with contradictions to do the operation procedure and general anesthesia, patients refuse to accept the condylectomy, or patients can't afford the extra cost for the application of digital techniques are excluded from this study

Primary outcomes:
measure: complications of condylectomy
timeFrame: post-operative day 7 and 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: South Zhongguancun Avenue22
country: China
facility: Peking University Hospital of Stomatology
state: Beijing
Study officials:
affiliation: Peking University School of Stomatology
name: xiaoxia wang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06143995: The Diagnosis and Treatment Pattern of CKD in Patients With Cardiovascular Disease- a National Cross-sectional Study
Official title: The Diagnosis and Treatment Pattern of CKD in Patients With Cardiovascular Disease- a National Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Renal Insufficiency, Chronic
Cardiovascular Diseases
Diagnosis
Lead sponsor: Guangdong Provincial People's Hospital
Sponsor class: OTHER
First posted: 2023-11-22
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: a total of approximately 2000 patients with cardiovascular disease recruited from about 25 participating sites in China

Brief summary: The goal of this observational study is to learn about in a total of approximately 2000 patients with cardiovascular disease recruited from about 25 participating sites in China with eGFR\<60 ml/min/1.73 m2 and/or UACR\>30 mg/g at least twice 3 months apart within the previous 12 months who had been hospitalized in the cardiology department within the previous 12 months. The main questions it aims to answer are:

* To estimate the diagnosis rate of CKD in patients with cardiovascular disease and laboratory evidence of CKD
* To describe the CKD awareness and treatment pattern in patients with cardiovascular disease and laboratory evidence of CKD.
* To describe the socio-demographic and clinical characteristics of CKD in patients with cardiovascular disease and laboratory evidence of CKD

Participants will be invited to undergo a baseline visit, and the demographics, lifestyle factors, clinical characteristics, and laboratory tests will be collected.


Eligibility criteria: Inclusion Criteria:

1. Female and/or male aged ≥18 years
2. Admitted to the cardiology department with diagnosed cardiovascular disease within the previous 12 months
3. Participants with eGFR\<60 ml/min/1.73 m2 and/or UACR\>30 mg/g at least twice 3 months apart within the previous 12 months

Exclusion Criteria:

1. Participants with known eGFR\<20 ml/min/1.73 m2 or undergoing dialysis or kidney transplantation
2. Pregnant or lactating women
3. Exposure to contrast medium or other reason leading to potential acute kidney injury since the baseline examination of eGFR/UACR
4. Patients who were participating in or had participated in any other clinical trial within the previous 12 months

Primary outcomes:
measure: CKD diagnosis rates
timeFrame: 1 day
Secondary outcomes:
measure: Clinical characteristics
timeFrame: 1 day
measure: CKD diagnosis/treatment rate
timeFrame: 1 day
measure: The number, types, treatment rates of medicine
timeFrame: 1 day
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
state: Guangdong
Study officials:
References:
Clinical trial NCT02372695: Effect of Paricalcitol Over Vessel Wall
Official title: Effect of Paricalcitol Over Vessel Wall: Pleiotropic Analogues Vitamin D Effects
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Nephropathy
Lead sponsor: Effice Servicios Para la Investigacion S.L.
Sponsor class: INDUSTRY
Collaborators: name: Jaume Arnó Renal Foundation
First posted: 2015-02-26
Enrollment: 50
Sex: ALL
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To provide evidence based prospectives of the potential benefit effects of paricalcitol, an analog of vitamin D, over the prevention / retardation of the progression of neoangiogenesis (vessels), atherosclerosis and vascular calcification.

Detailed description: Providing prospective results based on evidence of potential beneficial effects of paricalcitol, an analogue of vitamin D in the prevention / delay of progression of neoangiogenesis (vessels), atherosclerosis and vascular calcification.

Eligibility criteria: Inclusion Criteria:

* Patients aged between 50 and 75 years.
* Chronic kidney disease stage 5 D or 4-5 No D as calculated glomerular filtration rate (MDRD).
* Concentration of intact parathyroid hormone (iPTH): 150-400 pg/ml.
* Plasma concentrations of 25 (OH) vitamin D \<30 ng/ml.
* Without vitamin D supplementation for 3 months before the study.
* Serum P\> 3.8 mg / dl.
* Serum Ca\> 9.8 mg / dl.
* No history of cardiovascular events (angina or myocardial infarction, stroke, peripheral arterial disease).
* No exclusion criteria for the use of contrast.

Exclusion Criteria:

* Allergic reaction to sulfur hexafluoride.
* Recent unstable cardiac symptoms.
* Patients with recent coronary intervention (\<7 days)
* Patients with class III and IV heart failure or severe arrhythmias.
* Severe pulmonary hypertension.

Primary outcomes:
measure: Prevention on vessels progression based on paricalcitol intake.
timeFrame: participants will be followed for the duration of whole study, an expected average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Hospital Universitario Arnau de Vilanova de Lleida.
name: Maria Vittoria Arcidiacono, Ph D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06765395: Explore Association Models Between Environmental Hormones andBreast Cancer
Official title: Applying Machine Learning to Explore Association Models Between Environmental Hormones, Breast Cancer, and a Dietary and Health Education Improvement Program: An Investigative Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Breast Diseases
Breast Adenocarcinoma
Keywords: Machine learning; association model; environmental hormones; breast cancer
Lead sponsor: National Taipei University of Nursing and Health Sciences
Sponsor class: OTHER
First posted: 2025-01-09
Enrollment: 687
Sex: FEMALE
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study recruited research subjects from an outpatient clinic and ward of the Department of General Surgery of the Cheng Hsing General Hospital.

Brief summary: investigated the association model between environmental hormone-related living habits and breast cancer, as well as dietary improvement programs through machine learning and clinical validation of patients with breast cancer.

Detailed description: Female breast cancer is the second most common cancer worldwide and the age at diagnosis is decreasing. Traditional risk factor screening for breast cancer focuses on reproductive history, family history, age at menarche, and age at menopause; however, young patients diagnosed with breast cancer who do not meet the above risk factors are becoming common.This study established an association model between environmental hormones and breast cancer through machine learning to improve dietary programs to reduce the incidence of breast cancer.

Eligibility criteria: Inclusion Criteria:

* (1) patients aged 20 years or above; (2) patients with breast cancer.

Exclusion Criteria:

* non-patients with breast cancer

Primary outcomes:
measure: established an association model between environmental hormones and breast cancer
timeFrame: 2015~2024
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taipei university of Nursing and health science
state: Peitou
Study officials:
References:
Clinical trial NCT04556695: Exploration of Sedentary Behaviour Among General Practitioners: A Mixed Methods Study
Official title: Exploration of Sedentary Behaviour Among General Practitioners: A Mixed Methods Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sedentary Behavior
Keywords: General Practitioner
Primary Care
Sedentary Behaviour
Physical Activity
Lead sponsor: Queen's University, Belfast
Sponsor class: OTHER
Collaborators: name: University of Ulster
name: University of Southern Denmark
name: Loughborough University
First posted: 2020-09-21
Enrollment: 400
Sex: ALL
Minimum age (years): 23
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: General Practice Specialty Trainees (GPSTs) and General Practitioners (GPs) throughout Northern Ireland. GPs and GPSTs in Northern Ireland provide care for patients as part of the UK NHS, with working conditions similar to GPs and GPSTs throughout the rest of the UK.

Brief summary: A sequential, mixed-methods study exploring sedentary behaviour among General Practitioners and General Practice Specialty Trainees.

Detailed description: The study follows a sequential, mixed-methods model involving three stages. The first stage will involve the dissemination of a questionnaire survey, in which participants will self-estimate their sedentary behaviour on a working day and on a non-working day. The second stage will involve the use of thigh-worn accelerometers and a sleep/work log to obtain objective data regarding sedentary behaviour among a purposive subset of participants who responded to the questionnaire. The third stage will involve semi-structured interviews with a purposive subset of participants who wore the accelerometers, which will be analysed with the application of a theoretical framework regarding the acceptability of healthcare interventions.

Eligibility criteria: Inclusion Criteria:

Participants will be General Practitioners or General Practice Specialty Trainees working in Northern Ireland, United Kingdom.

Exclusion Criteria:

Not working as a General Practitioner or General Practice Specialty Trainee in Northern Ireland, United Kingdom.

Primary outcomes:
measure: Self-reported sedentary behaviour
timeFrame: Autumn 2020
measure: Accelerometer measured sedentary behaviour
timeFrame: Autumn 2021
measure: Thematic analysis of semi-structured interviews
timeFrame: Autumn 2021
Secondary outcomes:
Other outcomes:
Locations:
city: Belfast
country: United Kingdom
facility: Queen's University Belfast School of Medicine, Dentistry and Biomedical Sciences
Study officials:
affiliation: Centre for Public Health, Queen's University Belfast
name: Neil Heron
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00997295: Heat and Moisture Exchanger and Low-flow Gas
Official title: The Effects of a Heat and Moisture Exchanger on Temperature and Humidity in Low -Flow Anesthesia Workstation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Gynecological Surgery
General Anesthesia
Keywords: low flow gas
Heat and moisture exchanger
Humidity
Temperature
Core temperature
Women
Lead sponsor: UPECLIN HC FM Botucatu Unesp
Sponsor class: OTHER
Collaborators: name: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
First posted: 2009-10-19
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 69
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Thirty adult patients scheduled to gynecologic surgeries were randomly assigned in two groups to received fresh gas flow of 1 l.min-1 with or without in circle anesthesia system. Relative humidity, absolute humidity, temperature of gases and esophageal temperature were measured at 15 min (T0)after respiratory circuit installation and then every 30 min up to 120 min afterwards.

Brief summary: The aim of the present study was to measure the inspired gas temperature and humidity of the anesthetic circuit in the Dräger Primus machine and esophageal temperature with or without and heat and moisture exchanger (HME) and low-flow gas during anesthesia in patients submitted to gynecological surgeries.


Eligibility criteria: Inclusion Criteria:

* Women
* 18 to 69 years old
* Gynecological

Exclusion Criteria:

* Obesity
* Fever
* Endocrine disease

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Botucatu
country: Brazil
facility: College of Medicine of Botucatu
state: São Paulo
Study officials:
affiliation: Botucatu Medical Faculty
name: Jair Castro Jr, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: de Castro J Jr, Bolfi F, de Carvalho LR, Braz JR. The temperature and humidity in a low-flow anesthesia workstation with and without a heat and moisture exchanger. Anesth Analg. 2011 Sep;113(3):534-8. doi: 10.1213/ANE.0b013e31822402df. Epub 2011 Jun 16.
Clinical trial NCT01769495: Can a Rapid 2 Day Followup After Discharge From the ED Reduce Readmissions and Death for Patients 75 Years and Older?
Official title: A Randomized Trial of the Effect of a Geriatrics Appointment Within 2-3 Days of Discharge From the Emergency Department(ED) in Reducing ED and Hospital Readmissions for Patients 75 Years of Age and Older.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Emergencies
Keywords: Emergency department, Geriatrics, mortality, readmission rates.
Patients 75 years of age and older.
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
Collaborators: name: The Duke Endowment
name: The William R. Kenan, Jr. Charitable Trust
First posted: 2013-01-16
Enrollment: 26
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Our hypothesis is that a rapid follow up for elderly patients in a Geriatric Clinic discharged from the Emergency Department (ED) will have fewer unplanned return ED visits and fewer unplanned hospital admissions with no attendant increase in mortality.

Patients 75 years of age and older will be randomized following discharge from the ED into two groups. The first will receive standard post ED care. The second will receive an appointment to our Geriatric Clinic within 2-3 days for stabilization, further treatment and contact with the patient's primary physician to communicate the course of the patient's illness and to schedule subsequent follow-up with the patients regular medical provider.

There will be two primary outcomes: The first will be a composite of morality and/or return to the ED at 30 days, and the secondary primary outcome will be mortality. Economic data regarding resource utilization by patients will also be analyzed.


Eligibility criteria: Inclusion Criteria:

* All patients 75 years of age and older discharged from the ED

Exclusion Criteria:

* Younger than 75.

Primary outcomes:
measure: Mortality and readmissions to emergency department
timeFrame: 30 and 180 days
Secondary outcomes:
measure: Mortality
timeFrame: 30 and 180 days
Other outcomes:
measure: Medical Resource utilization
timeFrame: 30 days and 180 days
Locations:
city: Chapel Hill
country: United States
facility: UNC Hospitals
state: North Carolina
Study officials:
affiliation: UNC Chapel Hill, NC
name: John S Kizer, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02944695: Audit of Bronchoscopy Practice in Egypt: Adherence to Safety and Infection Control Guidelines
Official title: Adherence to Safety and Infection Control Guideline in Bronchoscopy Units
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Infection Control
Keywords: audit
infection control
bronchoscopy unit
Egypt
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2016-10-26
Enrollment: 80
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Bronchoscopy Units personnel: Physicians- Nurses-workers

Brief summary: Both patient and staff safety are of major importance during the procedure of fibreoptic bronchoscopy. Patient safety depends partly on adequate disinfection of instruments and accessories used as well as careful monitoring during the procedure.

Detailed description: Adequate facilities, manpower and training are also essential. Staff safety depends partly on adequate procedures to minimise any risks of sensitisation to agents such as glutaraldehyde. An audit well be carried out of bronchoscopy procedures in hospitals in the Egypt and the findings well be compared with published guidelines on good practice and clinical consensus

Eligibility criteria: Inclusion Criteria:

* Bronchoscopy Units personnel

Exclusion Criteria:

* N/A

Primary outcomes:
measure: Assessment of adherence to guidelines on disinfection procedures and patient monitoring
timeFrame: 3 months
Secondary outcomes:
measure: self- administered questionnaire
timeFrame: 3 months
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Pulmonology Departments
Study officials:
affiliation: Professor of Pulmonology- Faculty of Medicine-Assiut University
name: Aliae Mohamed-Hussein, MD
role: STUDY_CHAIR
References:
Clinical trial NCT04074395: Oral and Maxillofacial Pathology in Pediatric Patients
Official title: A Retrospective Analysis of Oral and Maxillofacial Pathological Lesions in Egyptian Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mouth Diseases
Keywords: oral pathology
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2019-08-30
Enrollment: 1000
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Biopsy records for children aged from 0 to 18 years

Brief summary: determination of the relative frequency of oral and maxillofacial pathological lesions among the Egyptian children and compare it with the global reports.

Detailed description: Oral and maxillofacial pathology in pediatric patients differs from the general population, as the nature of lesions in children changes with growth and development. Oral and maxillofacial pathology encompasses a wide spectrum of diseases, some of which (i.e. aphthous ulceration, geographic tongue, and herpes labialis) can be diagnosed on clinical presentation alone. For other soft tissue diseases and for pathology with bony components, incisional or excisional biopsy is mandatory to establish a definitive diagnosis .

Several studies illustrated that oral and maxillofacial pathology in pediatric populations varies based on the geographic location of the population as racial and environmental specificities and the lifestyle of each population may influence the prevalence of these diseases .

Although there is increasing literature regarding the incidence and prevalence of pediatric oral and maxillofacial pathology, there is no study investigating the range and frequency in Egyptian children.

Eligibility criteria: Inclusion Criteria:

* Biopsy records for children aged from 0 to 18 years

Exclusion Criteria:

* Biopsy records for patients older than 18
* Incomplete record regarding age, gender, location

Primary outcomes:
measure: Frequency of oral and maxillofacial pathological lesions among Egyptian children
timeFrame: one month
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
Study officials:
References: