louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00323245: Regaining Bladder Control in Postmenopausal Women With Osteoporosis
Official title: Regaining Urinary Continence in Postmenopausal Women With Osteoporosis: A Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Urinary Incontinence
Keywords: Randomized clinical trial
osteoporosis
urinary incontinence
physiotherapy
education
Lead sponsor: University of British Columbia
Sponsor class: OTHER
First posted: 2006-05-09
Enrollment: 48
Sex: FEMALE
Minimum age (years): 55
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Conservative management for urinary incontinence has been shown to improve bladder control. We are conducting a study of the effectiveness of conservative management for urinary incontinence in women who also have osteoporosis. We hope to find that treatment for incontinence improves bladder control and thereby allows women to be more active and reduces their risk of falling and breaking bones.


Eligibility criteria: Inclusion Criteria:

Postmenopausal women osteopenia or osteoporosis and stress urinary incontinence

Exclusion Criteria:

-

Primary outcomes:
measure: Number of Incontinent Episodes (baseline and end of treatment (12 weeks)
Secondary outcomes:
measure: Urinary Distress Inventory
measure: Pelvic Floor Muscle Strength
measure: Quality of life: Each participant will complete the Incontinence Impact Questionnaire and the SF-36 at the initial and follow up measurement sessions
measure: Physical Activity (PASE)
measure: 24 Hour Pad Test
measure: Voiding Frequency using the bladder diary
measure: Spinal Curvature with a flexicurve ruler
measure: Self-Perceived Efficacy
measure: All at initial and follow up (end) measurement sessions
Other outcomes:
Locations:
city: Vancouver
country: Canada
facility: BC Womens' Health Centre
state: British Columbia
Study officials:
affiliation: The University of British Columbia
name: Meena Sran, PT, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05520645: Etomidate Induction in Hysteroscopic Surgery
Official title: Randomized Controlled Study of Etomidate Induction in Hysteroscopic Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Etomidate Induced Dose
Hysteroscopic Surgery
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2022-08-30
Enrollment: 200
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study intends to study the optimal dose induced by etomidate in outpatients undergoing painless hysteroscopic surgery. At present, the dosage in the user manual is 0.1-0.3mg/kg. In clinical use, it is found that 0.1mg/kg often fails to achieve sedative effect, and 0.3mg/kg is prone to muscle twitching. Therefore, three groups of doses of 0.15mg/kg, 0.2mg/kg and 0.25mg/kg are set. It is hoped that this study will provide a basis for clinical evaluation of etomidate in anesthesia induction of hysteroscopic surgery.


Eligibility criteria: Inclusion Criteria:

Patients to undergo hysteroscopic surgery

Exclusion Criteria:

Hemo-dynamically unstable patients Allergic to egg protein Patients with epilepsy

Primary outcomes:
measure: Mean Arterial Pressure
timeFrame: Change in Mean Arterial Pressure(MAP) in mm of Hg from baseline value every 5 minutes for 30 minutes
measure: Heart rate per minute
timeFrame: Change in Heart rate per minute from baseline value every five minutes for 30 minutes
Secondary outcomes:
measure: Myoclonic movements
timeFrame: 60 seconds after injection of study drug
measure: Post Operative Nausea and Vomiting
timeFrame: Throughout entire study estimated to take 1 month to complete
measure: any oxygen saturation event below 85% by pulse oximetry
timeFrame: Throughout entire study estimated to take 1 month to complet
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01016145: Identifying Predictors of Response to Antipsychotics Using a Treatment Algorithm
Official title: Identifying Predictors of Response in 12 Weeks of Treatment With Antipsychotics Using a Treatment Algorithm for Schizophrenia
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Schizophrenia or Schizoaffective Disorder
Keywords: Schizophrenia
predictors of response
antipsychotics
18-45 years old
non-refractory
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2009-11-19
Enrollment: 126
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study is to evaluate predictors of response to antipsychotic medication in subjects with schizophrenia. The investigators will evaluate psychopathology,brain MRI, genetics and neuropsychological profile. Two groups of treatment will be compared: first generation antipsychotics vs. second generation antipsychotics. Participants will be randomized to one of the groups. Trial duration: 12 weeks.


Eligibility criteria: Inclusion Criteria:

* Schizophrenia or schizoaffective disorder
* Age: 18-45 years olde
* Less than 10 years of diagnosis
* Acute exacerbation of psychotic symptoms

Exclusion Criteria:

* Use of clozapine
* Clinical unstable disease
* Delirium and cognitive disorders

Primary outcomes:
measure: % responders to first generation antipsychotics vs. % responders to second generation antipsychotics
timeFrame: 8-12 weeks
Secondary outcomes:
measure: % of treatment abandon and respective causes
timeFrame: 8-12 weeks
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Instituto de Psiquiatria - Hospital das Clinicas FMUSP
Study officials:
References:
citation: Kayo M, Tassell I, Hiroce V, Menezes A, Elkis H. Does lack of improvement in the first two weeks predict treatment resistance in recent-onset psychosis? Clinics (Sao Paulo). 2012 Dec;67(12):1479-82. doi: 10.6061/clinics/2012(12)20. No abstract available.
Clinical trial NCT06197945: Effects of Mulligan Bent Leg Raise With and Without Bowen Therapy on Hamstring Tightness in Asymptomatic Adults
Official title: Effects of Mulligan Bent Leg Raise With and Without Bowen Therapy on Hamstring Tightness in Asymptomatic Adults
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Asymptomatic Condition
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2024-01-09
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Hamstring tightness is a common problem caused by a sedentary lifestyle and can have negative effects on posture and musculoskeletal function. It can lead to postural misalignment, increasing loading on the lumbar spine, increased pressure on inter-vertebral disc and potentially resulting in low back problems. Bowen technique and Mulligan Bent leg raise is used to treat conditions including hamstring tightness.

The goal of this clinical trial is to compare the effects of mulligan bent leg raise with and without Bowen therapy on hamstring tightness in asymptomatic adults.

Detailed description: A randomized control trial will be conducted at Riphah Rehabilitation Center and Physiogic Physiotherapy clinic on 50 asymptomatic adults who meet the inclusion criteria will be recruited using non probability purposive sampling and randomly allocated using Random Allocation Software 2.0. Informed consent will be obtained from all participants. They will be divided into two groups which will contain 25 participants in each group. Group A will receive three alternate sessions of Mulligan Bent Leg Raise with Bowen therapy and Group B will receive three alternate sessions of Mulligan Bent leg Raise. The Mulligan Bent Leg Raise technique will be performed with 3 repetition, 3-4 times with 20 sec hold and one minute rest between each repetition.

Eligibility criteria: Inclusion Criteria:

* Male/Female
* Age group between 18-40 years
* Unilateral limitation of SLR less than 75 degrees
* Asymptomatic, active knee extension less than 160 degrees

Exclusion Criteria:

* Fracture of Lower limb
* Individuals with soft tissue injury
* Chronic back pain
* Prolapsed Intervertebral disc
* Any surgery was done for back, pelvis hip or knee.
* Spinal deformity

Primary outcomes:
measure: Active Knee Extension Test
timeFrame: 1 week
measure: Sit and Reach Test
timeFrame: 1 week
measure: Straight Leg Raise Test
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Physiogic Physiotherapy Clinic
state: Punjab
Study officials:
affiliation: Riphah International University
name: Ali Raza, Masters
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05403645: Comparison of Exercise Therapy Vs Mobilization With Movement Among Patients With Knee Osteoarthritis
Official title: Comparison of Exercise Therapy Vs Mobilization With Movement Among Patients With Knee Osteoarthritis in Household Females
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Knee Osteoarthritis
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2022-06-03
Enrollment: 34
Sex: FEMALE
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: this study will help to Compare the effect of Exercise Therapy and Movement With Mobilization among patients with knee osteoarthritis in household females
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Comparison of exercise therapy Vs mobilization with movement among patients with knee osteoarthritis in household females

Detailed description: To determine the effect of exercise therapy and mulligan\*s mobilization with movement techniques on pain and difficulty in performing ADLs with knee OA in household females.

Eligibility criteria: Inclusion Criteria:

* Subject with age group of 40-60 included in this study.
* History of knee osteoarthritis, with grade I or II.
* No impairment in other body parts.
* Patients already diagnosed with osteoarthritis by orthopedic surgeon.

Exclusion Criteria:

* Patients with communication problems
* Patients with a history of previous stroke or other neurological diseases or disorders.
* Patients with inflammation.
* Patients who had undergone any surgery.
* Infection or dermatological conditions.
* cardiovascular problems (unstable angina, recent myocardial infarction within the last three months, congestive heart failure, significant heart valve dysfunction etc).

Primary outcomes:
measure: Exercise Therapy
timeFrame: 6 Months
Secondary outcomes:
measure: Movement With Mobilization
timeFrame: 6 Months
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Superior University
Study officials:
References:
Clinical trial NCT01324245: Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet
Official title: Paracrine Regulation of Renal Function by Dopamine in Normotensive Humans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Salt-sensitive Hypertension
Keywords: Salt
Balance
Renin Angiotensin System
Fenoldopam\blood Pressure
Sodium
Lead sponsor: Georgetown University
Sponsor class: OTHER
Collaborators: name: University of Virginia
First posted: 2011-03-28
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: The kidney plays a crucial role in maintaining salt balance by two opposing physiological mechanisms: the renal dopaminergic system which enhances salt excretion and the renin-angiotensin system (RAS) which causes salt retention. Salt-sensitive hypertension occurs when this balance is altered or abnormal. We hypothesized that this balance is influenced by salt intake: therefore dietary salt affects the natriuretic response to the renal dopaminergic agonist Fenoldopam, and the Angiotensin Converting Enzyme inhibitor, Enalapril.

In this trial we study normal salt balance mechanisms in salt resistant adults with normal blood pressure.

Detailed description: Eight adults of both genders and all races were studied in this double blind placebo controlled cross over study with randomization of the order of interventions. After 5 days each on low salt (about 1 gram/day) and high salt (about 6 grams/day)diet, with a washout period of at least four weeks in between, every subject was treated with Enalapril and Placebo on two consecutive days, followed by a Fenoldopam infusion for three hours, during which natriuresis and renal function testing were performed.

Eligibility criteria: Inclusion Criteria:

* Volunteers
* Healthy
* Normal Blood Pressure

Exclusion Criteria:

* Renal Impairment
* Obesity
* Salt sensitive increase in blood pressure

Primary outcomes:
measure: Urinary sodium excretion
timeFrame: During the trial: a 3 hour fenoldopam infusion
Secondary outcomes:
measure: Renal Plasma Flow
timeFrame: During 3 hour fenoldopam infusion
Other outcomes:
Locations:
city: Washington
country: United States
facility: Georgetown University Medical Center
state: District of Columbia
Study officials:
affiliation: Georgetown University Hospital
name: Aruna R Natarajan, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Georgetown University/ George Washington University
name: Pedro A Jose, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00823745: Radiolabel ADME (Absorption, Distribution, Metabolism, and Excretion) Study Of [14C] PF-00868554 In Healthy Adult Male Subjects
Official title: A Phase 1 Study To Evaluate The Metabolism And Excretion Of [14C] PF-00868554 In Healthy Adult Male Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: HCV
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2009-01-16
Enrollment: 7
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: This is a phase 1 study to assess the routes of elimination of a single oral dose of \[14C\] PF-00868554 and to characterize the metabolic profile following single dose administration.


Eligibility criteria: Inclusion Criteria:

* Male, healthy volunteers.

Exclusion Criteria:

* Females.

Primary outcomes:
measure: The amount of radioactivity recovered in urine and feces, as a percent of the dose.
timeFrame: 7 weeks
measure: The amount of PF-00868554, expressed as a percent of total radioactivity, in plasma, urine, and feces.
timeFrame: 7 weeks
measure: Identification and determination of relative abundance of the metabolites of PF-00868554 in plasma, urine, and feces.
timeFrame: 7 weeks
measure: PK parameters: AUClast, AUCinf, maximum concentration (Cmax), time of maximum concentration (Tmax), and half-life (t1/2) to describe the single dose PK of a) total radioactivity in blood; b) total radioactivity in plasma; c) PF-00868554 in plasma.
timeFrame: 7 weeks
Secondary outcomes:
measure: Safety endpoints including adverse events, clinical laboratory tests, vital signs and ECGs.
timeFrame: 7 weeks
Other outcomes:
Locations:
city: Tacoma
country: United States
facility: Pfizer Investigational Site
state: Washington
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References:
Clinical trial NCT02060045: Prevention Ventilator Associated Pneumonia
Official title: Impact of 4 Sequential Measures on the Prevention of Ventilator Associated Pneumonia in Major Heart Surgery Intensive Care Unit
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ventilator-associated Pneumonia
Keywords: bundle
prevention
Disturbance; Heart, Functional, Postoperative, Cardiac Surgery
Lead sponsor: Hospital General Universitario Gregorio Marañon
Sponsor class: OTHER
Collaborators: name: Ciber de Enfermedades Respiratorias
name: Fundación Rafael del Pino
name: Fondo de Investigacion Sanitaria
First posted: 2014-02-11
Enrollment: 1534
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The objective of the investigators work was to evaluate the impact of 4 sequentially implemented measures for preventing VAP in a major heart surgery ICU. The measures were a specific training program, aspiration of subglottic secretions (ASS), introduction of an inclinometer to improve the semirecumbent position, and reinforcement of oral care with chlorhexidine.


Eligibility criteria: Inclusion Criteria:

* all patients with heart surgery admitted in critical care unit during the study period

Exclusion Criteria:

* none

Primary outcomes:
measure: Change (reduction) in the incidence density of Ventilator associated pneumonia (VAP)
timeFrame: Baseline and up to 35 months
Secondary outcomes:
measure: Change(length) in Intensive Care Unit (ICU) stay
timeFrame: Baseline and up to 35 months
measure: Change (number of days) in Mechanical Ventilator (MV) per ICU stay
timeFrame: Baseline and up to 35 months
measure: Change in mortality rate
timeFrame: Baseline and up to 35 months
measure: Change in cost of antimicrobial acquisition during ICU stay
timeFrame: Baseline and up to 35 months
measure: Change in compliance with the measures
timeFrame: Baseline and up to 35 months
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: Hopsital General Universitario Gregorio Marañon
Study officials:
affiliation: Hospital General Universitario Gregorio Marañón
name: Maria Jesus Perez, RN
role: PRINCIPAL_INVESTIGATOR
References:
citation: Perez-Granda MJ, Barrio JM, Munoz P, Hortal J, Rincon C, Bouza E. Impact of four sequential measures on the prevention of ventilator-associated pneumonia in cardiac surgery patients. Crit Care. 2014 Mar 26;18(2):R53. doi: 10.1186/cc13799.
Clinical trial NCT01007045: Limited Compression Ultrasound by Emergency Physicians to Exclude Deep Vein Thrombosis
Official title: Can Emergency Physicians Safely Exclude Proximal Deep Vein Thrombosis Using Limited Compression Emergency Department Ultrasound?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Deep Vein Thrombosis
Keywords: deep vein thrombosis
venous thromboembolic disorders
diagnostic ultrasound
Lead sponsor: Queen's University
Sponsor class: OTHER
Collaborators: name: The Physicians' Services Incorporated Foundation
First posted: 2009-11-03
Enrollment: 227
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: emergency patients suspected of deep vein thrombosis

Brief summary: Deep vein thrombosis is a common condition seen in the Emergency Department. Standard of care for diagnosis of DVT includes a combination of a clinical pre-test probability rule known as Well's criteria, D-dimer blood testing, and Radiology department ultrasound.

The purpose of this study is to determine whether Emergency Physicians can safely rule out deep vein thrombosis using Well's criteria and D-dimer blood testing combined with Emergency department bedside ultrasound.


Eligibility criteria: Inclusion Criteria:

* Age \> 16 years
* Clinically suspected lower extremity DVT

Exclusion Criteria:

* Known chronic DVT
* Acute DVT confirmed by prior formal imaging
* Inability to assess common femoral or popliteal area (due to cast, above knee amputation, etc.)
* Anticoagulation \>48 hours prior to imaging (formal or LCU)

Primary outcomes:
measure: First co-primary outcome: sensitivity/specificity of LC U/S vs D-dimer in clinically "unlikely" DVT patients.
timeFrame: 3 days
measure: Second co-primary outcome: sensitivity/specificity of LC U/S plus D-dimer vs formal ultrasound in clinically "likely" DVT patients.
timeFrame: 3 days
Secondary outcomes:
measure: interobserver reliability of modified Well's criteria
timeFrame: 3 days
measure: learning curve for LC U/S by emergency physicians and residents
timeFrame: 365 days
measure: difference in diagnostic time interval for patients grouped by pre-test probability
timeFrame: 3 days
measure: number of return visits for formal ultrasound imaging
timeFrame: 3 days
measure: number of patients receiving empirical anticoagulation while formal ultrasound imaging is pending
timeFrame: 3 days
Other outcomes:
Locations:
city: Kingston
country: Canada
facility: Kingston General Hospital
state: Ontario
city: Kingston
country: Canada
facility: Hotel Dieu Hospital
state: Ontario
Study officials:
affiliation: Queen's University
name: Rachel Poley, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Poley RA, Newbigging JL, Sivilotti ML. Estimated effect of an integrated approach to suspected deep venous thrombosis using limited-compression ultrasound. Acad Emerg Med. 2014 Sep;21(9):971-80. doi: 10.1111/acem.12459.
Clinical trial NCT00776945: Feasibility and Functionality of fPAM Imaging in Melanoma
Official title: Determine the Feasibility and Functionality of fPAM Imaging for the in Vivo Characterization and Early Diagnosis of Melanoma
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Melanoma
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2008-10-22
Enrollment: 2
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Stage I - III melanoma.

Brief summary: Melanoma is a cutaneous malignancy that has the potential for local (skin) and regional (lymph node) recurrence. These recurrences may be difficult to detect in their earliest stages. We are attempting to use novel form of skin imaging that uses ultrasound combined with laser to identify these recurrences early, when they may be most amenable to treatment. This imaging will detect melanoma pigment below the surface of the skin and in the draining lymph nodes, as well as new blood vessel formation that occurs with these loco-regional metastases.

Detailed description: recruiting healthy individuals with pigmented lesions and individuals with melanoma and pigmented lesions

Eligibility criteria: Inclusion Criteria:

* Adult patients (\> 18 yrs of age) with recently diagnosed or a history of, Stage I - III melanoma who are able to give informed consent.

Exclusion Criteria:

* Patients with melanomas \< 1mm.
* Pregnant females.
* Children and young adults \< 18 yrs of age and patients who are unable to give informed consent.

Primary outcomes:
measure: fPAM is a hybrid imaging technique that detects absorbed diffuse photons ultrasonically through the photoacoustic (PA) effect
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
city: Saint Louis
country: United States
facility: Washington University
state: Missouri
city: St. Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
Study officials:
affiliation: Washington University School of Medicine
name: Lynn A Cornelius, MD
role: PRINCIPAL_INVESTIGATOR
References: