Clinical trial NCT04650763: Bone Healing in Immediate Dental Implants
Official title: Effect of PRP on Bone Healing in Immediate Implants Analyzed by CBCT
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alveolar Bone Loss
Platelet Rich Plasma
Keywords: Dental implant, Cone Beam Computerized Tomography (CBCT).
Lead sponsor: CMH Lahore Medical College and Institute of Dentistry
Sponsor class: OTHER
First posted: 2020-12-03
Enrollment: 12
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To study the effect of platelet-rich plasma concentrate on marginal bone loss and bone mineral density in immediate implant placement through CBCT.

Detailed description: 12 subjects were equally categorized into two groups. Group, I was the control group; whereas, the subjects in Group II received Platelet Rich Plasma (PRP) therapy. All subjects were given a standard treatment with single implant system. Inserted implants were analyzed through Cone Beam Computerized Tomography (CBCT). Records were registered at the baseline, at 12th week before functional loading and 26th week after functional loading.

Eligibility criteria: Inclusion Criteria:

* patients maintaining good oral hygiene, having adequate bone quantity at the implant site, uneventful extraction

Exclusion Criteria:

* Active infection around implant site, immunocompromised state, with current major systemic disease (uncontrolled diabetes, rheumatoid arthritis, etc.) or oral pathologies, history of bleeding disorders or on anticoagulant therapy, or patients on bisphosphonates were excluded from the study

Primary outcomes:
measure: Measurement of bone loss at baseline (12 weeks) and later at 26weeks
timeFrame: Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT
Secondary outcomes:
measure: Measurement of bone loss at baseline (12 weeks) and later at 26weeks
timeFrame: Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT
Other outcomes:
measure: Bone Mineral Density
timeFrame: Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT
Locations:
city: Lahore
country: Pakistan
facility: Institute of Dentistry; CMH Lahore Medical College
state: Punjab
Study officials:
affiliation: Institute of Dentistry; CMH Lahore Medical College
name: Aleshba Saba khan, BDS; FCPS
role: PRINCIPAL_INVESTIGATOR
affiliation: Institute of Dentistry; CMH Lahore Medical College
name: Naauman Zaheer, BDS; PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Institute of Dentistry; CMH Lahore Medical College
name: Abdul Mueed Zaigham, BDS; FCPS
role: STUDY_CHAIR
affiliation: Oral Biology Department; Rashid Latif Dental College, Lahore
name: Maliha Shahbaz, BDS; MPhil
role: STUDY_DIRECTOR
affiliation: Lahore Medical & Dental College
name: Usman Zaheer, BDS; FCPS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Boora P, Rathee M, Bhoria M. Effect of Platelet Rich Fibrin (PRF) on Peri-implant Soft Tissue and Crestal Bone in One-Stage Implant Placement: A Randomized Controlled Trial. J Clin Diagn Res. 2015 Apr;9(4):ZC18-21. doi: 10.7860/JCDR/2015/12636.5788. Epub 2015 Apr 1.
citation: Khan AS, Zaheer N, Zaigham AM, Shahbaz M, Zaheer U, Alam MK. Effect of Platelet-Rich Plasma on Bone Healing in Immediate Implants Analyzed by Cone Beam Computerized Tomography: A Randomized Controlled Trial. Biomed Res Int. 2021 Mar 13;2021:6685991. doi: 10.1155/2021/6685991. eCollection 2021.