Clinical trial NCT06021886: CS Scar Impact on ART Outcomes
Official title: CS Scar Impact on ART Outcomes
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Fertility Issues
Keywords: CS Scar Impact on ART Outcomes
Lead sponsor: HealthPlus Fertility Center
Sponsor class: OTHER
First posted: 2023-09-01
Enrollment: 510
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All women who underwent an embryo transfer with a Euploid embryo between 2005 and 2022, who meet the inclusion criteria will be included in the study. To compare the success rates and outcomes of pregnancies of frozen embryo transfer for euploid embryos in patients without caesarean section, and who had caesarean section (with or without a NICHE) after euploid embryo transfer.

Brief summary: CS scar impact on ART outcomes, Retrospective Cohort Study IVF outcome can be affected by the presence of caesarean section scar with or without defect in different ways

Detailed description: CS scar impact on ART outcomes, Retrospective Cohort Study IVF outcome can be affected by the presence of caesarean section scar with or without defect in different ways; increase difficulty of embryo transfer, presence intrauterine fluid at the time of transfer can affect the chances of embryo implantation and increase the rate of spontaneous miscarriages To compare the success rates and outcomes of pregnancies of frozen embryo transfer for euploid embryos in patients without caesarean section, and who had caesarean section (with or without a NICHE) after euploid embryo transfer. Does CS scar and CS scar defect affect IVF outcome? All women who underwent an embryo transfer with a Euploid embryo between 2015 and 2022, who meet the inclusion criteria will be included in the study.

* Inclusion Criteria: Age 25-40 years old. Euploid embryo transfer. Medically free BMI less tha 30 kg/m2 Hormone therapy preparation for FET.
* Exclusion criteria Previous uterine scar other than cesarean section. Congenital uterine abnormalities Presence of intrauterine lesions e.g., polyp, fibroid, Endometriosis or adenomyosis Hydrosalpinx, Chronic endometritis
* Primary outcome: Clinical pregnancy rate, defined as a pregnancy with a detectable heart rate at 7 weeks of gestation or beyond.
* Secondary outcomes : Early pregnancy complications Ectopic pregnancy or Miscarriage. Caesarean section scar dehiscence or

Eligibility criteria: Inclusion Criteria:

* Age 25-40 years old.

Euploid embryo transfer.

Medically free

BMI less tha 30 kg/m2

Hormone therapy preparation for FET.

Exclusion Criteria:

- Exclusion criteria

Previous uterine scar other than cesarean section.

Congenital uterine abnormalities

Presence of intrauterine lesions e.g., polyp, fibroid,

Endometriosis or adenomyosis

Hydrosalpinx, Chronic endometritis

Primary outcomes:
measure: CS scar impact on ART outcomes, Retrospective Cohort Study
timeFrame: 2015 to 2022,
Secondary outcomes:
measure: ART outcomes
timeFrame: 2015 to 2022,
Other outcomes:
Locations:
city: Abu Dhabi
country: United Arab Emirates
facility: HealthPlus fertility Centre
Study officials:
References: