louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00525122: Treatment of M.Graves With Radioactive Iodine: Follow-up Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hyperthyroidism
Keywords: hyperthyroidism
radioactive iodine
antithyroid drugs
Hyperthyroidism, treatment with radioactive iodine without antithyroid drugs
Lead sponsor: Medisch Centrum Rijnmond-Zuid, Netherlands
Sponsor class: OTHER_GOV
First posted: 2007-09-05
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients of 18 years and older with hyperthyroidism who are eligible for treatment with radioactive iodine.

Brief summary: Hypothesis: What is the natural course after treatment with radioactive iodine in patients with hyperthyroidism?

What are the determinants for the development of acute hypo- or hyperthyroidism after treatment with radioactive iodine without antithyroid drugs?


Eligibility criteria: Inclusion Criteria:

* Patients wth hyperthyroidism who are eligible for treatment with radioactive iodine
* Age \> 18 years

Exclusion Criteria:

* Severe ophthalmopathy
* Pregnancy or wish to pregnancy on short term
* Breastfeeding
* Patients already treated with radioactive iodine
* Known cardiovascular diseases or other severe comorbidity

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Rotterdam
country: Netherlands
facility: MCRZ
state: Zuid-Holland
Study officials:
affiliation: Medisch Centrum Rijnmond-Zuid, Netherlands
name: A. Berghout, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Medisch Centrum Rijnmond-Zuid, Netherlands
name: C. van Noord, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02813122: The Use of X-ray in Bariatric Surgeries
Official title: The Use of X-ray in Bariatric Surgeries
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Complications of Bariatric Procedures
X-rays; Effects
Lead sponsor: Assuta Medical Center
Sponsor class: OTHER
First posted: 2016-06-24
Enrollment: 8000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients underwent bariatric surgery between 2011-2015

Brief summary: examination of the importance of the use of X-ray in bariatric surgery outcome.

Detailed description: the x-ray will be used in order to evaluate the number of complications occured during bariatric surgeries such as bleeding, leak, etc. a retrospective analysis of patients with those complications will be performed and the presence of the x-ray and its findings will also be documented.

Eligibility criteria: Inclusion Criteria:

first bariatric surgery

Exclusion Criteria:

recurrent bariatric surgery

Primary outcomes:
measure: complications
timeFrame: retrospective- data collection and analysis will be ended in six months.
Secondary outcomes:
Other outcomes:
Locations:
city: Tel-Aviv
country: Israel
facility: Assuta Medical Center
Study officials:
affiliation: Assuta Medical Center
name: Sergio G Susmallian, M.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Susmallian S, Folb E, Barnea R, Raziel A. Comparison of Imaging Modalities for Detecting Complications in Bariatric Surgery. Obes Surg. 2018 Apr;28(4):1063-1069. doi: 10.1007/s11695-017-2970-5.
Clinical trial NCT00877422: Vitamin D Supplementation Prevents Elderly Pneumonia
Official title: Vitamin D Supplementation Prevents Pneumonia in Institutionalized Elderly Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bacterial Pneumonia
Keywords: vitamin deficiency
Lead sponsor: Tohoku University
Sponsor class: OTHER
First posted: 2009-04-07
Enrollment: 100
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Pneumonia is the fourth leading cause of death and frequently occurs in institutionalized elderly people in Japan. Recently, several clinical and experimental studies have reported the importance of vitamin D in the regulation of immune functions and its deficiency is associated with susceptibility to some infections. In the present study, the investigators hypothesize that deficiency of serum vitamin D is associated with development of pneumonia, and supplementation of vitamin D may lower the incidence of pneumonia and prolong survival in institutionalized elderly subjects.


Eligibility criteria: Inclusion Criteria:

* Subjects are more than 65 years old and were resident in the facility for at least 6 months.
* Subjects have no conditions known to interfere with vitamin D metabolism.

Exclusion Criteria:

* Subjects are excluded if they have:

  * renal failure
  * hepatic failure
  * hyper- or hypo-parathyroidism
  * HIV infection, or malignant diseases
* Subjects are also excluded if they are taking corticosteroid, thiazide diuretics, or supplementary vitamins.

Primary outcomes:
measure: prevalence of pneumonia
timeFrame: one year
Secondary outcomes:
measure: all cause mortality
timeFrame: one year
Other outcomes:
Locations:
city: 1-1,Seiryo-machi,Aoba-ku,Sendai
country: Japan
facility: Institute of Development, Aging and Cancer, Tohoku University
Study officials:
affiliation: Department of Geriatrics and Gerontology, Tohoku University
name: Hiroyuki Arai, MD
role: STUDY_CHAIR
References:
Clinical trial NCT06094322: Evaluation of Rapid T2-weighted and DWI MR Sequences Reconstructed by Deep Learning for Prostate Imaging
Official title: Advanced DL-based T2w and DWI MR Sequences for Prostate Imaging
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Prostate Cancer
Keywords: T2 FSE
T2 DLR
diffusion DWI
diffusion DLR
Deep Learning Prostate cancer
PIRADS
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2023-10-23
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: MR prostate exam is essential for the diagnosis, workup and follow-up of prostate cancer. It allows to detect subclinical prostate cancer following an increase in the level of PSA. The investigators can score the lesion according to the PIRADS classification and obtain an estimate of lesion malignancy. To perform this classification, T2 and DWI sequences are essential.

Detection and characterization of malignant lesion is important to address appropriate patient care pathway. The purpose of this project is to evaluate novel deep learning (DL) T2-weighted TSE (T2DL) and Diffusion (DWIDL) sequences for prostate MR exam and investigate its impact on diagnostic, examination time, image quality, and PI-RADS classification compared to standard T2-weighted TSE (T2S) and standard Diffusion (DWIS) sequences.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 ans
* Healthy subject without history of hepatic disease
* Patient addressed for an prostate MRI
* Ability to give consent

Exclusion Criteria:

* claustrophobia,
* major obesity (\>140 kg),
* Patient under guardianship or curators
* Age \< 18 years,
* Women,
* History of prostatectomy or irradiation of the prostate
* any contraindication to MRI exam

Primary outcomes:
measure: Change in number of suspicious nodule prostate detection before and after rapid T2-weighted
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Amiens
country: France
facility: Centre Hospitalier Universitaire d'Amiens
state: Picardie
Study officials:
References:
Clinical trial NCT00094822: Pegfilgrastim Given Same Day As or Day After Carboplatin and Docetaxel in Advanced Metastatic Non-Small Cell Lung Cancer (NSCLC)
Official title: Pegfilgrastim Given Same Day as or Day After Carboplatin and Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Cancer
Non-Small Cell Lung Cancer
Keywords: Metastatic Cancer
Neulasta®
pegfilgrastim
Lead sponsor: Amgen
Sponsor class: INDUSTRY
First posted: 2004-10-27
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Advanced or Metastatic NSCLC

Brief summary: The purpose of this research study is to evaluate the safety and effectiveness of Neulasta® (pegfilgrastim) in reducing infection when given on the same day versus one day after the completion of chemotherapy (docetaxel and carboplatin) in patients with advanced or metastatic non-small cell lung cancer (NSCLC). This study is considered to be "investigational" because previous studies with Neulasta® used next day dosing and not same day dosing.


Eligibility criteria: Eligibility Criteria: - Age 18 years or older - Diagnosis of advanced or metastatic non-small cell lung cancer (NSCLC) - Have not received any prior chemotherapy - Have not received radiation therapy or undergone major surgery within the past 2 weeks

Primary outcomes:
measure: incidence of infection
timeFrame: during treatment
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Amgen
name: MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01712022: Evaluation of Corneal Epithelial Thickness Mapping
Official title: Evaluation of Corneal Epithelial Thickness Mapping
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dry Eye and Contact Lens Wear
Lead sponsor: Optovue
Sponsor class: INDUSTRY
First posted: 2012-10-23
Enrollment: 88
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: seeing eye doctor for routine or follow-up care

Brief summary: Optovue has developed a new feature for mapping corneal epithelial thickness. The purpose of the study is to evaluate the accuracy and repeatability of the epithelial thickness measurement. Consented subjects will undergo a series of cornea measurements using optical coherence tomography (OCT) that will be used for analysis.


Eligibility criteria: Inclusion Criteria:

* 18 years of age or older
* Able and willing to provide consent
* Able and willing to complete the required examinations
* DRY EYE GROUP ONLY: Clinical diagnosis of dry eye
* CONTACT LENS GROUP ONLY: Regular contact lens wear

Exclusion Criteria:

* History of ocular surgery
* History of laser refractive surgery
* History of cataract surgery
* DRY EYE GROUP ONLY: Corneal pathology not associated with dry eye
* CONTACT LENS GROUP ONLY: Corneal pathology including dry eye
* NORMAL GROUP ONLY: History of contact lens wear or dry eye or corneal pathology

Primary outcomes:
measure: corneal epithelial thickness
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Fishman Vision
state: California
city: San Diego
country: United States
facility: Gordon-Weiss-Schanzlin Vision Institute
state: California
city: Latham
country: United States
facility: Brass Eye Center
state: New York
Study officials:
References:
Clinical trial NCT04062422: Ulna Length in Black Children
Official title: Prediction of Childhood Pulmonary Function Using Ulna Length in Children of Sub-saharian or Caribbean Ethnicity
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ulna Length in Otherwise Healthy Children (With the Exception of Mild to Moderate Asthma)
Keywords: ulna; healthy children; height predicted
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2019-08-20
Enrollment: 350
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: child between 3 to 18 years old, two parents of sub-saharian or caribbean origin, referred for asthma suspicion or follow-up

Brief summary: Height measurement is unreliable when neuromuscular weakness or spinal deformity is present. The aim of this study was to accurately predict pulmonary function from a limb segment (ulna) measurement that is precise and reproducible. Equations are available in caucasian children but are not available in children of sub-saharian or caribbean ethnicity, which was the aim of the study. To this end, 350 black children referred for pulmonary function testing for asthma follow-up will be included.

Detailed description: Ulna (dominant and non-dominant arm), height measurement in 350 asthmatic children of sub-saharian or caribbean ethnicity (both parents). Repeatability analysis (ulna and height) for the first fifty children. Recording of pulmonary function tests results (spirometry, resistance measurements)

Eligibility criteria: Inclusion Criteria:

* age: 3 to 18 years old, two parents of sub-saharian or caribbean origin, referred for asthma suspicion or follow-up.

Exclusion Criteria:

* chronic disease excepting asthma, prematurity (\<36 GW), steroid (\>3/year), high dosage of inhaled steroid

Primary outcomes:
measure: Ulna length
timeFrame: 12 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Robert Debre Hospital
Study officials:
affiliation: APHP
name: Christophe Delclaux, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Beydon N, Leye F, Bokov P, Delclaux C. Prediction of height using ulna length in African-Caribbean children. Pediatr Pulmonol. 2022 Sep;57(9):2032-2039. doi: 10.1002/ppul.25972. Epub 2022 May 21.
Clinical trial NCT04026022: Traumatologic Acute Pain Management With Fentanyl Transdermal Therapeutic System (TTS)
Official title: Perioperative Off-label Application (From Admission up to 72 Hours Postoperatively) of Fentanyl TTS as Part of a Pain Management in Comparison to a Certified Pain Medication Management in Adult Patients With a Hip Fracture.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Hip Fractures (ICD-10 72.01-72.2)
Lead sponsor: Medical University of Graz
Sponsor class: OTHER
First posted: 2019-07-19
Enrollment: 145
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aim of the study is an examination whether a modified perioperative pain management system, that integrates the 2017 European Society of Anaesthesiology (ESA) guidelines for treatment of postoperative Delirium, can improve patient's wellbeing in comparison to the current certified standard management.

Detailed description: Aim of the study is to evaluate whether the integration of the 2017 ESA guidelines for treatment of postoperative Delirium in a pain management, can improve patient's wellbeing in comparison to the current certified standard management. Adherence to the modified management includes minimizing nil per os time, renouncing benzodiazepines, 1.8 ltr crystalloid infusion per day, simplified standard medication option and postoperative 12µg/h Fentanyl TTS for 72h (for wound pain).

Eligibility criteria: Inclusion Criteria:

* adult patients with hip fractures that have to be operated (ICD S72.01-S72.2)

Exclusion Criteria:

* severe liver damage
* ongoing dialysis therapy
* Monoamine oxidase inhibitor intake
* inability to give consent to trial participation

Primary outcomes:
measure: Patient's wellbeing in the awakening room
timeFrame: 1 year
Secondary outcomes:
measure: Complication rate (delirium, periprosthetic fractures, wound infections etc)
timeFrame: Through study completion, an average of 10 days
measure: Efficacy of the pain management in reducing pain
timeFrame: Through study completion, an average of 10 days
measure: Interview assessed identification of selfreported parameters influencing patient-wellbeing
timeFrame: Through study completion, an average of 72 hours postoperatively
Other outcomes:
Locations:
city: Graz
country: Austria
facility: Medical University Hospital LKH Graz
Study officials:
References:
Clinical trial NCT06909422: Mobile Thinking Intervention: A Inital Test
Official title: A Mobile Intervention to Enhance Your Mood: A Test of the Acceptability and Efficacy
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Schizophrenia
Clinical High Risk for Psychosis (CHR)
Lead sponsor: University of Alabama at Birmingham
Sponsor class: OTHER
First posted: 2025-04-03
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study will test the inital efficacy of a brief mobile intervention targeting biased thinking.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of schizophrenia or related psychotic disorder OR
* Identified as being at clinical high risk for psychosis in symptom interviews

Exclusion Criteria:

* Recent changes in mental health treatment in past month or two months if on depot

Primary outcomes:
measure: Defeatist Beliefs Scale - 15
timeFrame: Measured at Baseline and post intervention (6 weeks)
measure: Brief Negative Symptoms Scale
timeFrame: Measured at Baseline and post intervention (6 weeks)
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
Study officials:
References:
citation: Granholm E, Holden J, Dwyer K, Mikhael T, Link P, Depp C. Mobile-Assisted Cognitive Behavioral Therapy for Negative Symptoms: Open Single-Arm Trial With Schizophrenia Patients. JMIR Ment Health. 2020 Dec 1;7(12):e24406. doi: 10.2196/24406.
Clinical trial NCT02411422: Comparison of Efficiency Between I-gel Blind Intubation and I-gel Bronchoscopic Intubation During Resuscitation
Official title: Comparison of Efficiency Between I-gel-Assisted Blind Intubation and I-gel-assisted Bronchoscopic Intubation During Cardiopulmonary Resuscitation: Randomized Simulation Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Arrest
Keywords: intubation
cardiopulmonary resuscitation
manikins
Lead sponsor: Hallym University Kangnam Sacred Heart Hospital
Sponsor class: OTHER
First posted: 2015-04-08
Enrollment: 23
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: The investigators will compare conventional intubation using Macintosh laryngoscope, blind endotracheal intubation using i-gel for conduit and bronchoscopic intubation using Ambu-aScope and i-gel. All situation assumed as cardiac arrest. i.e, someone give chest compressions continuously without interruption.

Moreover the investigators will compare the type of endotracheal tube. Reinforced tube has more soft tube tip, so the investigators think it is more acceptable for intubation using i-gel as conduit.


Eligibility criteria: Inclusion Criteria:

* emergency physician
* work at emergency department more than 1 year.
* 50 or more experience of endotracheal intubation

Exclusion Criteria:

* having backache or wrist pain

Primary outcomes:
measure: intubation time
timeFrame: 1 Day
Secondary outcomes:
measure: success rate for intubation
timeFrame: 1 Day
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Kangnam Sacred Heart Hospital
state: Yeongdeungpo-gu
Study officials:
References:
Clinical trial NCT01280422: Analysis of Drug-drug Interaction Alert Based on Multicenter Clinical Database
Official title: Analysis of Drug-drug Interaction Alert Based on Multicenter Clinical Database
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Drug Interaction Alert
Keywords: ROCDR
Lead sponsor: Taipei Medical University WanFang Hospital
Sponsor class: OTHER
First posted: 2011-01-20
Enrollment: 67128927
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients

Brief summary: The doctor's overridden rate for Drug-drug interaction (DDI) alert systems was 85-95% in foreign and there was more than 90% overridden rate in Taiwan. Why DDI alerts systems which spent much time and money to establish could not use medicinal information to increase drug safety? One of the reasons which induced to override was that health care thought there were too much DDI alerts and high false alerts.

The difference between DDI alert systems from pharmacists to confirm drug-drug interaction was that pharmacists not only confirmed ordering drug at the same time but also checked the other drug information such as frequency, rote and refill etc. Therefore, DDI alert systems which were established by drug code alone would induce a lot of false alerts.

In order to study how much false alert rate in drug-drug interactions, this research selected most common drug-drug interaction which was antacids and antibiotics. Antacids were most self-payment so this research needed to analyze ROCDR (Establishing a Multi-Center, Longitudinal, Research-Oriented Clinical Data Repository for Clinical Research). The aim was to study how many drug-drug interactions and false alerts from antacids and antibiotics and analyze the difference in different department. Finally, proposing advice and assessment for building drug-drug interaction alerts system to strength drug information system and increase drug safety.


Eligibility criteria: Inclusion Criteria:

* Select DDI rules: antacids and antibiotics
* Database: ROCDR (multicenter clinical database)
* The pharmacists defined six rules which were based on medical knowledge for true alerts or false-alert.

  1. True alert: Rule 1 and Rule 2
  2. "False-alert": Rule 3 or Rule 4
  3. "Other" (Unable to determine): Rule 5 or Rule 6

Exclusion Criteria:

* N/A

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University - WanFang Hospital
Study officials:
affiliation: Taipei Medical University WanFang Hospital
name: Yu-Chuan Li
role: PRINCIPAL_INVESTIGATOR
References: