Clinical trial NCT06282640: Comparıson Of Electromyography Results Before And After Vıtamın D Treatment In Patıents Wıth Carpal Tunnel Syndrome
Official title: Comparıson Of Electromyography Results Before And After Vıtamın D Treatment In Patıents Wıth Carpal Tunnel Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Carpal Tunnel Syndrome
Vitamin D Deficiency
Keywords: Carpal Tunnel Syndrome
Vitamin D Deficiency
Electrophysiologia
Lead sponsor: Kayseri Education and Research Hospital
Sponsor class: OTHER_GOV
Collaborators: name: Kayseri City Hospital
First posted: 2024-02-28
Enrollment: 87
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Therefore, we aimed to evaluate the effectiveness of vitamin D replacement therapy on pain, electrophysiological parameters, ultrasonographic measurement results and functional status scales in CTS patients with low serum vitamin D levels.

Detailed description: Introduction: Apart from its effect on bone health, vitamin D is also known to have beneficial effects on the neurological system. In studies, vitamin D levels were found to be low in patients with Carpal Tunnel Syndrome (CTS). However, studies examining the effects of vitamin D replacement on CTS are limited. Therefore, we aimed to evaluate the effectiveness of vitamin D replacement therapy on pain, electrophysiological parameters, ultrasonographic measurement results and functional status scales in CTS patients with low serum vitamin D levels. Materials and Methods: Our study was planned as an observational and analytical prospective. Vitamin D loading therapy was given to patients with serum vitamin D levels below 20ng/ml and mild-moderate CTS detected by electroneuromyography (ENMG). Patients with vitamin D levels above 20 ng/ml after 8 weeks were included in the study. Each patient was given a rest splint and exercise program. Patients were evaluated before and 3 months after treatment with electrophysiological, ultrasonographic, VAS, pinch-grip strength, two-point discrimination, monofilament test and Boston symptom severity scale.

Eligibility criteria: Inclusion Criteria:

* 18-70 years old male or female gender
* Those with mild to moderate CTS according to ENMG,
* Vitamin D level \<20.

Exclusion Criteria:

* Severe CTS according to ENMG
* Thenar region atrophy
* diabetes mellitus,
* rheumatoid arthritis,
* hyperthyroidism,
* hypothyroidism
* Traumatic nerve injury, history of surgery
* Polyneuropathy
* Pregnancy
* Severe psychiatric illness
* Poor orientation and cooperation,
* Injection (corticosteroid, ozone, stem cell...) applied for CTS treatment within 3 months

Primary outcomes:
measure: electrophysiological scale.
timeFrame: at the baseline and immediately after treatment
Secondary outcomes:
measure: monofilament test
timeFrame: at the baseline and immediately after treatment
Other outcomes:
measure: Boston symptom severity scale
timeFrame: at the baseline and immediately after treatment
Locations:
city: Kayseri
country: Turkey
facility: Kayseri City Hospital
Study officials:
References: