louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06935929: A Study on the Associations Between Microribonucleic Acid Gene Polymorphisms and Crohn's Disease
Official title: A Study on the Associations Between Microribonucleic Acid Gene Polymorphisms and Crohn's Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Crohn Disease
Lead sponsor: Second Affiliated Hospital of Wenzhou Medical University
Sponsor class: OTHER
First posted: 2025-04-20
Enrollment: 839
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: There was no statistically significant difference in the gender ratio, average age, and proportion of smokers between CD group and normal control group. All study subjects are from the Zhejiang Han population who are not related by blood.

Brief summary: From January 2020 to January 2025, Crohn's disease (CD) patients and gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University. The aim of this research is to explore the associations of microribonucleic acids (miRNAs) gene polymorphisms with the risk and clinicopathological characteristics of CD, and to analyze the effects of miRNAs gene variantions on the clinical response of ustekinumab (UST) treatment in CD patients at week 8.

Detailed description: From January 2020 to January 2025, a total of 312 CD patients and 527 gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.The genotypes of miRNAs were determined by multiplex polymerase chain reaction-ligase detection reaction technique. Unconditional logistic regression was employed to analyze the distribution of miRNAs gene polymorphisms between CD group and normal control group, as well as their influences on the clinicopathological characteristics of CD patients. Unconditional logistic regression model was used to explore the effect of miRNAs gene variation on the clinical response of CD patients in the treatment of UST at week 8.

Eligibility criteria: Inclusion Criteria:

* diagnosed CD based on comprehensive clinical, colonoscopy, histopathological, laboratory, and radiographic examination results

Exclusion Criteria:

* rheumatoid arthritis, systemic lupus erythematosus, intestinal tuberculosis, ischemic enteritis, radiation enteritis, tumors, etc.

Primary outcomes:
measure: the genotypes of miRNAs
timeFrame: Baseline
Secondary outcomes:
measure: clinical response of ustekinumab treatment
timeFrame: week 8
Other outcomes:
Locations:
city: Wenzhou
country: China
facility: the Second Affiliated Hospital of Wenzhou Medical University
state: Zhejiang
Study officials:
References:
Clinical trial NCT06340529: Comparison of the Perception of Non-technical Skills
Official title: Comparison of the Perception of Non-technical Skills by Students, Self-assessment and Teachers, Developed During the Clinical Simulation in Students of the Degree in Physiotherapy
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Healthy
Keywords: Physioterapy
Students
Clinical Simulation
Learning methodology
Lead sponsor: University of Valencia
Sponsor class: OTHER
First posted: 2024-04-01
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: Clinical simulation has recently acquired great importance in the health sciences. It is a pedagogical methodology that is increasingly used in health science degrees, since it is very useful for the acquisition of both technical and non-technical skills (leadership, teamwork and effective communication, among others).

However, if the investigators focus on physical therapy, the use of clinical simulation is a novel field and therefore requires a great deal of research. Researchers in this field do not yet have the consistency and experience as in other health branches such as medicine or nursing, where the participants have been using high-fidelity simulators for years for the learning of all their students.

Clinical simulation allows students to achieve these competencies without the need to practice on real patients. For all these reasons, and because of the situation of need generated in recent years, in which internships in hospitals and clinical centers were completely suppressed, the need for our research is justified.


Eligibility criteria: Inclusion Criteria:

* Second year students of the Physiotherapy Degree
* They do not have clinical experience with real patients.
* Subject teachers

Exclusion Criteria:

* Not wanting to sign to participate in the study.
* Not signing the informed consent
* Teachers who do not have experience in clinical simulation

Primary outcomes:
measure: Ottawa Scale
timeFrame: 2 week, 4 week, 6 week.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of Valencia
name: Carmen Casal-Angulo, PhD RN
role: STUDY_DIRECTOR
References:
Clinical trial NCT03178929: Effect of SAMe Treatment on Recurrence After Radical Treatment of Primary Hepatic Carcinoma
Official title: A Randomized Controlled Study on the Effect of S-Adenosyl Methionine Treatment on Anti-tumor Recurrence After Radical Treatment of Primary Hepatic Carcinoma
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Primary Liver Cancer
Lead sponsor: Beijing Insight Science & Technology Co. Ltd.
Sponsor class: OTHER
First posted: 2017-06-07
Enrollment: 207
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this study is to explore the effect of SAMe on recurrence after radical treatment of Primary liver cancer.

Detailed description: Primary liver cancer is now a major health problem. In the worldwide, PLC is the fifth most common cancer in male, the seventh in female, and has the second highest rate to cause death for men . Although the recent advances in treatment of Primary liver cancer have significantly improved the prognosis of patients with Primary liver cancer, the overall survival rate is still unsatisfactory. One of the reasons for the poor prognosis of Primary liver cancer is its high rate of recurrence. Anti-relapse treatment remains a pressing work to do.

In recent years, some study reported that SAMe had an impact on promoting apoptosis and inhibiting the growth on breast cancer, colon cancer, gastric cancer and liver cancer in vitro and vivo.

In this study, we aim to examine whether SAMe have an effect on improving patients' recurrence after radical treatment of Primary liver cancer.

Eligibility criteria: Inclusion Criteria:

* Patient must sign the informed consent prior to the beginning of any study-related procedures;
* Patients diagnosed of Primary liver cancer;
* BCLC Stage：Stage 0、Stage A;
* Accept radical treatment;

Exclusion Criteria:

* With any other anti-cancer treatment before or after the surgery;
* Patients with extrahepatic metastasis;
* Patients with apparent cardiac, pulmonary, cerebral and renal dysfunction;
* Subjects accepting other trial drugs or participating in other clinical trials;
* Female with pregnancy or during the lactation period.

Primary outcomes:
measure: Time to tumor recurrence
timeFrame: 2 years
Secondary outcomes:
measure: Overall survival
timeFrame: 2 years
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04556929: Enhanced Detection in Glioma Excision
Official title: Improving Fluorescence-guided Brain Tumour Surgery With Ultra-high Sensitivity Imaging
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Glioma
Keywords: 5-Aminolevulinic acid (5-ALA)
Malignant glioma
Tumor resection
Lead sponsor: University of Oxford
Sponsor class: OTHER
Collaborators: name: Oxford University Hospitals NHS Trust
First posted: 2020-09-21
Enrollment: 4
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to determine whether use of an ultra-high sensitivity camera with enhanced imaging technology can be used during surgery to detect areas of brain tissue affected by diffuse glioma, a type of brain cancer.


Eligibility criteria: Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study.
* Male or Female, aged 18 years or above.
* Female patients are not pregnant at time of surgery.
* Patient has consented to craniotomy for suspected glioma of any type with 5-ALA infusion.

Exclusion Criteria:

• Participants are participating in another trial at time of operation

Primary outcomes:
measure: Level of tumour fluorescence in images of resection cavity captured during surgery
timeFrame: Intra-operative
Secondary outcomes:
measure: Duration of operation stages
timeFrame: Intra-operative
Other outcomes:
Locations:
city: Oxford
country: United Kingdom
facility: John Radcliffe Hospital
state: Oxfordshire
Study officials:
affiliation: University of Oxford
name: Puneet Plaha, MD FRCS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01460329: Comparing Cardiac Output Measurements in Critically Ill Children Using USCOM and Transthoracic ECHO
Official title: Comparing Cardiac Output Measurements in Critically Ill Children Using Ultrasonic Cardiac Output Monitor and Transthoracic Echocardiography.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Critical Illness
Pediatrics
Keywords: intensive care units
pediatric
cardiac index
Doppler Ultrasonography
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
First posted: 2011-10-26
Enrollment: 22
Sex: ALL
Minimum age (years): 1
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The subjects for this study can be either male or female and not limited by race or ethnicity. They will include critically ill pediatric patients, less than 18 yrs of age, being treated in the Pediatric intensive care unit.

Brief summary: The purpose of this study is to compare the accuracy and precision of two non-invasive methods of measuring cardiac output in critically ill children (\<18 yrs). The participants will include any patient admitted to Pediatric intensive care unit (PICU) requiring a trans-thoracic ECHO (TTE) as part of their treatment plan. Measurements of intermittent cardiac output will be obtained and compared on participants using standard 2-D TTE and Ultrasound Cardiac Output Monitor (USCOM).


Eligibility criteria: Inclusion Criteria:

* Any UNC PICU patient \<18 yrs requiring a transthoracic ECHO (TTE) as standard of care.
* Gestational age \>36 weeks
* Wt \> 2 kg
* Written informed parental permission

Exclusion Criteria:

* Any patient with known unrepaired intracardiac shunt lesion (ASD,PDA,VSD)
* any post operative patient with delayed closure of chest
* parental refusal to participate

Primary outcomes:
measure: Cardiac Index
timeFrame: measured at the time of study
Secondary outcomes:
Other outcomes:
Locations:
city: Chapel Hill
country: United States
facility: UNC Children's Hospital
state: North Carolina
Study officials:
affiliation: East Carolina University
name: Nina J Verdino, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of North Carolina, Chapel Hill
name: Keith C Kocis, MD
role: STUDY_CHAIR
References:
Clinical trial NCT04144829: Platelet-rich Fibrin Versus HIFU in Management of Stress Urinary Incontinence
Official title: Platelet-rich Fibrin Versus HIFU in Management of Stress Urinary Incontinence
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Stress Urinary Incontinence
Lead sponsor: Intima Clinic
Sponsor class: INDUSTRY
First posted: 2019-10-30
Enrollment: 200
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aim of the study is to compare effect of High Intensity Focused Ultrasound (HIFU) and platelet-rich fibrin in management of stress urinary incontinence.

It is a randomized prospective study. After assigning to one of the two groups, patients will undergo relevant treatment.

First group will undergo 3 cycles of intravaginal HIFU treatment in 6-weeks interval.

Second group will undergo 3 injections of platelet-rich fibrin under urethra. Before the treatment and after 2, 6 and 12 months after treatment is finished patients will be asked to fill questionaries concerning quality of life ICIQ-UI SF, ICIQ-LUTS, PISQ12, FSFI.

Before each treatment cycle patients will be examined and asked to fill daily micturition plan.


Eligibility criteria: Inclusion Criteria:

* stress urinary incontinence of low grade
* separate episodes of urinary incontinence (associated with increase of abdominal pressure)
* no cystocoele or cystocoele POPQ1
* positive cough test when filled bladder

Exclusion Criteria:

* POPQ 2 and more
* patients after urogenital operations or radiation
* neuromuscular, hematologic, autoimmune, uncontrolled psychiatric diseases
* uncontrolled diabetes
* pregnancy, lactation
* patients undergoing conservative treatment for stress urinary incontinence
* ASA or other anti-platelet drug intake less than 7 days before and 7 days after procedure
* active carcinomas or status less than 5 years after treatment
* sepsis
* infection in treated region

Primary outcomes:
measure: Improvement of patient's comfort and satisfaction
timeFrame: 1 year
measure: Improvement of patient's comfort and satisfaction
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Krakow
country: Poland
facility: Intima Clinc
state: Malopolskie Voivodeship
Study officials:
affiliation: Intima Clinic
name: Tomasz Basta, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04998929: A Common But Unknown Disease; Nave Sliding (NS)
Official title: A Common But Unknown Disease; A Case Series Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Navel; Hernia
Keywords: nave sliding
abdominal wall defect
Lead sponsor: Komar University of Science and Technology
Sponsor class: OTHER
First posted: 2021-08-10
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 20 patients who following repeated hospital visits did not improve, and for their last try, they visited a traditional clinic, and were diagnosed with nave sliding

Brief summary: The present study is a case series study, conducted to introduce a common disease of abdominal wall which has received less attention in scientific resources. The study population was all patients who following repeated hospital visits did not improve, and for their last try, they visited a traditional clinic, and were diagnosed with umbilical hernia.

Detailed description: Background: The present study is conducted to introduce a common disease of abdominal wall which has received less attention in scientific resources. In traditional medicine sources Some scholars believe that this condition occurs due to the movement of the abdominal muscle near the umbilicus or nave laterally movement of nave.

Design: A case series study Method: This study was a case series study. The study population was all patients who following repeated hospital visits did not improve, and for their last try, they visited a traditional clinic, and were diagnosed with umbilical hernia during a period of 5 months.

Eligibility criteria: inclusion Criteria:

* Clinical diagnosis of nave sliding
* Must be able to provide a complete health history information

Exclusion Criteria:

* unwillingness to continue
* any unexpected complication of traditional treatment

Primary outcomes:
measure: Demographic information questionnaire
timeFrame: 1 hour through study completion
measure: standard form of health history taking
timeFrame: 5 hour through study completion
measure: body mass index
timeFrame: once at admission time
Secondary outcomes:
Other outcomes:
Locations:
city: Sulaymaniyah
country: Iraq
facility: Komar University
state: Iran
Study officials:
References:
Clinical trial NCT04490629: The Efficacy and Safety of a Latest Dural Substitute
Official title: A Prospective, Multi-center, Randomized, Parallel-controlled Clinical Trial Evaluating the Efficacy and Safety of Lyoplant Onlay in Repairing Cerebral Dura Mater
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cerebrospinal Fluid Leak
Keywords: Dura Mater
Cerebrospinal Fluid Leak
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2020-07-29
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This prospective, multi-center, randomized, parallel-controlled clinical trial was designed to evaluate the efficacy and safety of Lyoplant Onlay in repairing cerebral dura mater. DURAFORM was regarded as the control group. a total of 80 patients were randomized into experimental and control group (1:1).Data were collected on complications resulting in CSF leaks, surgical site infections, instrument performance parameterized other neurological complications within 30 days. Surgeons also provided data on the ease of use of the dural sealing techniques, as well as preparation and application times. The above-mentioned date were used to evaluate the efficacy and safety of Lyoplant Onlay .


Eligibility criteria: Inclusion Criteria:

* Any patient between the ages of 18 and 75 years scheduled for elective cranial surgery involving a dural incision.
* Dural defects and surgical incision was classifed as level 1

Exclusion Criteria:

* local or systemic infection.
* patients with known allergy to Equipment components
* a history of traumatic head injury
* a compromised immune system or autoimmune disease
* patients who should not participate based on the surgeon's opinion
* patients participating in any other drug or device trial.
* expected survival time \<12 months
* underwent chemoradiotherapy 3 months before randomization
* uncontrolled diabetes and malignant tumor
* women who were pregnant, lactating, or wished to become pregnant during the study;

Primary outcomes:
measure: surgical successful rate
timeFrame: at 30 days post surgery
Secondary outcomes:
measure: neurosurgical complication
timeFrame: 2 days post surgery/10 days post surgery/at 30 days post surgery
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Jianmin Zhang
state: Zhejiang
Study officials:
affiliation: Department of neurosurgery
name: jianmin zhang, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04052529: Tracking Our Lives Study
Official title: Impact of Using Self-monitoring Smartphone Applications on College Students' Well-being
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mental Health Wellness 2
Health Behavior
Eating Disorders
Lead sponsor: University of Michigan
Sponsor class: OTHER
First posted: 2019-08-09
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: College women are at risk for eating disorders, which have profound health impacts. Cross-sectional studies have shown that the use of dietary self-monitoring is associated with eating disorder risk among college students. However, causality cannot be established with cross-sectional studies.

This study utilizes a randomized controlled trial design to examine how the use of a popular dietary self-monitoring smartphone application impacts college females' well-being, including eating disorder risk. We hypothesize those who are randomized to dietary self-monitoring will have a greater increase in eating disorder risk compared to the control group.


Eligibility criteria: Inclusion Criteria:

* University of Michigan Ann Arbor undergraduate student
* Daily access to a smartphone
* Female gender
* At least 18 years of age
* Fluent in English

Exclusion Criteria:

* Self-reported history of any medical condition that impacts the types or amount of food eaten
* Self-reported recent use of dietary self-monitoring
* Self-reported history of an active or past eating disorder
* Eating Disorder Examination Questionnaire Short Form (EDE-QS) score ≥ 2, indicating high eating disorder risk

Primary outcomes:
measure: Eating Disorder Risk
timeFrame: 30 days
measure: Eating Disorder Risk
timeFrame: 30 days
Secondary outcomes:
measure: Weight-Related Self-Monitoring
timeFrame: 30 days
measure: Body Image
timeFrame: 30 days
measure: Weight Stigma
timeFrame: 30 days
measure: Dietary Intake
timeFrame: 30 days
measure: Physical Activity
timeFrame: 30 days
measure: Weight perception
timeFrame: 30 days
measure: Body changing intentions
timeFrame: 30 days
measure: Social Media Use
timeFrame: 30 days
measure: Weight
timeFrame: 30 days
measure: Subjective Quality of Life
timeFrame: 30 days
measure: Anxiety
timeFrame: 30 days
measure: Depression Symptoms
timeFrame: 30 days
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
Study officials:
References:
citation: Hahn SL, Kaciroti N, Eisenberg D, Weeks HM, Bauer KW, Sonneville KR. Introducing Dietary Self-Monitoring to Undergraduate Women via a Calorie Counting App Has No Effect on Mental Health or Health Behaviors: Results From a Randomized Controlled Trial. J Acad Nutr Diet. 2021 Dec;121(12):2377-2388. doi: 10.1016/j.jand.2021.06.311. Epub 2021 Aug 20.
Clinical trial NCT03295929: 3D Model of Posterior Membranous Labyrinth of the Inner Ear
Official title: 3D Finite Element Model of Posterior Membranous Labyrinth From in Vivo MRI of Human Temporal Bone
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Reconstruction of the Posterior Membranous Labyrinth
Keywords: 3D model
Inner ear
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2017-09-28
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult who has performed an imaging of the inner ear

Brief summary: The aim of this work is to create a three-dimensional (3D) finite element model (FEM) of the human posterior membranous labyrinth, based on in vivo inner ear magnetic resonance imaging (MRI). This model has a pedagogical interest, and can serve as a basis for reflection in cases of atypical benign paroxysmal positional vertigos. It can also serve for mechanical studies of vestibular physiology.


Eligibility criteria: Inclusion Criteria:

* Patient aged 18 or over
* Adult who has performed an imaging of the inner ear

Exclusion Criteria:

* Refusal to participate in the study

Primary outcomes:
measure: Measure of dimensions of the model to study the validity of the geometry
timeFrame: Creation of 3D model: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: Service D'Orl Et de Chirurgie Cervico-Faciale
Study officials:
References: