Clinical trial NCT06172504: Ejaculation Frequency and Semen Parameters
Official title: Effect of Male Ejaculation Frequency on Semen Parameters
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Sperm
Fertility
Keywords: Semen Parameters
Ejaculation Frequency
the penultimate abstinence period
Lead sponsor: The First Hospital of Jilin University
Sponsor class: OTHER
First posted: 2023-12-15
Enrollment: 1500
Sex: MALE
Minimum age (years): 22
Maximum age (years): 45
Standard ages: ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The participants were men who underwent semen examination in the andrology clinic of the Reproductive Center of the First Hospital of Jilin University. Including pre-conception, infertility, and his wife with a history of pregnancy loss.

Brief summary: The goal of this observational study is to determine whether the frequency of ejaculation in men had an effect on semen parameters.. The main questions it aims to answer are:

* question 1：Whether the frequency of ejaculation has an effect on semen parameters
* question 2：Whether the penultimate abstinence period has an effect on semen parameters

The participants were men who underwent semen examination in the andrology clinic of the Reproductive Center of the First Hospital of Jilin University. A brief medical history was collected from each volunteer, including demographic information, fertility history and as well as information regarding their general health.The focus of the investigation is the time of abstinence for this examination, the penultimate abstinence period, and the number of ejaculation since the last 1 month.

Detailed description: The main subjects of this study were husbands who underwent semen examination, Including pre-conception, infertility, and his wife with a history of pregnancy loss. Before the examination, the basic information such as age, height, weight, smoking, drinking, infertility years, fertility and pregnancy history, marriage years, education, occupation and exclusion criteria have adverse effects on sperm were investigated.The focus of the investigation is the time of abstinence for this examination, the penultimate abstinence period, and the number of ejaculation since the last 1 month. According to World Health Organization standards, semen analysis requires abstinence for 48h to 7 days. Semen parameters were recorded, including sperm DNA fragmentation rate, sperm motility rate, total sperm count, sperm motility, and sperm morphology. The frequency of ejaculation was divided into four groups:(1)0-4 times/month;(2)5-8 times/month;(3) 8-12 times/month;(4) \>12 times/month.

Eligibility criteria: Inclusion Criteria:

1. Normal ejaculation function, normal sexual life, masturbation can ejaculate
2. Male age between 22 and 45 years old.
3. According to World Health Organization standards, the semen examination time is within 48h to 7 days of abstinence.

Exclusion Criteria:

1. The man was diagnosed with extremely severe oligospermia (sperm concentration \<1 million/ml) and azoospermia.
2. Identify the factors affecting semen parameters, long-term exposure to high temperature, long-term exposure to chemicals, heavy metals, radiation and other toxic and harmful substances, orchitis/epididymitis, cryptorchidism, radiotherapy and chemotherapy treatment, and taking drugs to improve sperm within three months

Primary outcomes:
measure: Effect of ejaculation frequency on sperm DNA fragmentation rate
timeFrame: 6 months
measure: Effect of ejaculation frequency on sperm motility rate
timeFrame: 6 months
measure: Effect of ejaculation frequency on total sperm count
timeFrame: 6 months
measure: Effect of ejaculation frequency on sperm vitality rate
timeFrame: 6 months
measure: Effect of ejaculation frequency on sperm morphology
timeFrame: 6 months
Secondary outcomes:
measure: Effect of the penultimate abstinence period on DNA fragmentation rate
timeFrame: 6 months
Other outcomes:
Locations:
city: Changchun
country: China
facility: the first hospital of Jilin University
state: Jilin
Study officials:
affiliation: The First Hospital of Jilin University
name: yang yu
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Barbagallo F, Cannarella R, Crafa A, Manna C, La Vignera S, Condorelli RA, Calogero AE. The Impact of a Very Short Abstinence Period on Conventional Sperm Parameters and Sperm DNA Fragmentation: A Systematic Review and Meta-Analysis. J Clin Med. 2022 Dec 8;11(24):7303. doi: 10.3390/jcm11247303.
citation: Stanford JB, White GL, Hatasaka H. Timing intercourse to achieve pregnancy: current evidence. Obstet Gynecol. 2002 Dec;100(6):1333-41. doi: 10.1016/s0029-7844(02)02382-7.