Clinical trial NCT05418998: Cognitive Training to Improve Mobility in Middle-aged and Older Adults
Official title: Training Cognition to Improve Mobility and Listening in Older Adults with Hearing Loss: Moving from Lab to Life
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging
Age Related Hearing Loss
Keywords: Cognitive training
Executive function
Aging
Dual-task walking
Near-infrared spectroscopy
Hearing loss
Middle age
Mobility
Lead sponsor: Concordia University, Montreal
Sponsor class: OTHER
Collaborators: name: Canadian Institutes of Health Research (CIHR)
First posted: 2022-06-15
Enrollment: 63
Sex: ALL
Minimum age (years): 45
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The proposed study is designed to evaluate the effect of at-home executive function training on cognition and mobility in older adults with age-related hearing loss (ARHL), older adults with normal hearing, and middle-aged adults.


Eligibility criteria: Inclusion Criteria:

* Proficient in English (learned before age 5), can ambulate ≥ 10 meters independently, absence of cognitive impairment (neuropsychological test results in the average range compared to age norms), normal or corrected-to-normal visual acuity (ETDRS), availability of a home computer or tablet with internet connection.

Exclusion Criteria:

* Reported major depression, substance abuse or significant psychiatric disorder, uncorrected visual impairment, vestibular impairment, Parkinson's disease or other neurological disorder or sequelae, clinically significant musculoskeletal disorders, diseases affecting the ear, or damage to the ear (e.g., occupational noise), onset of hearing loss prior to adulthood.

Primary outcomes:
measure: Pre-training Change in auditory 2-back accuracy
timeFrame: baseline
measure: Post-training Change in auditory 2-back accuracy
timeFrame: after 12 weeks
measure: Pre-training Change in auditory 2-back reaction time
timeFrame: baseline
measure: Post-training Change in auditory 2-back reaction time
timeFrame: after 12 weeks
measure: Pre-training Multi-Talker word perception (accuracy)
timeFrame: baseline
measure: Post-training Multi-Talker word perception (accuracy)
timeFrame: after 12 weeks
measure: Pre-training Change in stride time (mean, standard deviation [SD] of stride time)
timeFrame: baseline
measure: Post-training Change in stride time (mean, standard deviation [SD] of stride time)
timeFrame: after 12 weeks
measure: Pre-training Change in stride time variability (mean, standard deviation [SD] of stride time)
timeFrame: baseline
measure: Post-training Change in stride time variability (mean, standard deviation [SD] of stride time)
timeFrame: after 12 weeks
Secondary outcomes:
measure: Pre-training Montreal Cognitive Assessment (MoCA)
timeFrame: baseline
measure: Post-training Montreal Cognitive Assessment (MoCA)
timeFrame: after 12 weeks
measure: Pre-training WAIS-IV Digit Symbol Coding
timeFrame: baseline
measure: Post-training WAIS-IV Digit Symbol Coding
timeFrame: after 12 weeks
measure: Pre-training Trail Making Test
timeFrame: baseline
measure: Post-training Trail Making Test
timeFrame: after 12 weeks
measure: Pre-training D-KEFS Stroop
timeFrame: baseline
measure: Post-training D-KEFS Stroop
timeFrame: after 12 weeks
measure: Pre-training Rey Auditory Verbal Learning Test
timeFrame: baseline
measure: Post-training Rey Auditory Verbal Learning Test
timeFrame: after 12 weeks
measure: Pre-training WAIS-IV Digit span
timeFrame: baseline
measure: Post-training WAIS-IV Digit span
timeFrame: after 12 weeks
measure: Pre-training Subjective listening self efficacy
timeFrame: baseline
measure: Post-training Subjective listening self efficacy
timeFrame: after 12 weeks
measure: Pre-training Subjective balance confidence
timeFrame: baseline
measure: Post-training Subjective balance confidence
timeFrame: after 12 weeks
measure: Pre-training Mobility functioning as assessed by the Mini BESTest
timeFrame: baseline
measure: Post-training Mobility functioning as assessed by the Mini BESTest
timeFrame: after 12 weeks
measure: Pre-training Functional neuroimaging (fNIRS)
timeFrame: baseline
measure: Post-training Functional neuroimaging (fNIRS)
timeFrame: after 12 weeks
measure: Pre-training Standing Balance (Path length)
timeFrame: baseline
measure: Pre-training Standing Balance (Velocity)
timeFrame: baseline
measure: Pre-training Standing Balance (Variability)
timeFrame: baseline
measure: Post-training Standing Balance (Path length)
timeFrame: after 12 weeks
measure: Post-training Standing Balance (Velocity)
timeFrame: after 12 weeks
measure: Post-training Standing Balance (Variability)
timeFrame: after 12 weeks
Other outcomes:
Locations:
city: Montreal
country: Canada
facility: Concordia University
state: Quebec
Study officials:
References: