Clinical trial NCT05047263: A Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease
Official title: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Phase 3 Study to Investigate the Efficacy and Safety of FInerenone, in Addition to Standard of Care, on the Progression of Kidney Disease in Patients With Non-Diabetic Chronic Kidney Disease
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Non-diabetic Chronic Kidney Disease
Lead sponsor: Bayer
Sponsor class: INDUSTRY
First posted: 2021-09-17
Enrollment: 1584
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury and inflammation in the heart and kidney which is known to play a role in CKD.

In this trial, the researchers want to learn if finerenone helps to slow down the worsening of the participants' non-diabetic CKD compared to a placebo. A placebo looks like a trial treatment but does not have any medicine in it. The trial will include about 1,580 men and women who are at least 18 years old.

The participants will take finerenone or a placebo once a day as tablets by mouth. All of the participants will also continue to take their current medicine for their CKD. The participants will be in the trial for up to about 50 months.

During the trial, the doctors will collect blood and urine samples and check the participants' health. The participants will also answer questions about how they are feeling and what adverse events they are having. An adverse event is a medical problem that happens during the trial. Doctors keep track of all adverse events that happen in trials, even if they do not think the adverse events might be related to the trial treatments.


Eligibility criteria: Inclusion Criteria:

* A clinical diagnosis of chronic kidney disease and:

  * Urine albumin/creatinine ratio (UACR) of ≥ 200 but ≤ 3500 mg/g and estimated glomerular filtration rate (eGFR) ≥ 25 but \< 90 mL/min/1.73m\^2 at screening, and
  * Documentation of albuminuria/proteinuria in the participant's medical records at least 3 months prior to screening.
* Stable and maximum tolerated labeled dose of an Angiotensin-converting enzyme inhibitor (ACEI) or Angiotensin receptor blocker (ARB) for at least 4 weeks prior to screening
* K+ ≤ 4.8 mmol/L at screening

Exclusion Criteria:

* Established diagnosis of Type 1 or 2 Diabetes mellitus, or HbA1c ≥ 6.5% (48 mmol/mol)
* Autosomal dominant or autosomal recessive polycystic kidney disease
* Lupus nephritis or anti-neutrophilic cytoplasmic autoantibody (ANCA) -associated vasculitis or any other primary or secondary kidney disease requiring immunosuppressive therapy within 6 months prior to screening
* Symptomatic heart failure with reduced ejection fraction with class 1A indication for Mineralocorticoid receptor antagonists (MRAs)

Primary outcomes:
measure: Mean rate of change as measured by the total slope of eGFR from baseline to Month-32.
timeFrame: From baseline to month 32
Secondary outcomes:
measure: Time to the composite of kidney failure, sustained eGFR decline of >= 57%, heart failure hospitalization or Cardiovascular (CV) death
timeFrame: Up to end of study visit (up to approximately 49 months)
measure: Time to the composite of kidney failure or sustained eGFR decline of >= 57%
timeFrame: Up to end of study visit (up to approximately 49 months)
measure: Time to the composite to heart failure hospitalization or CV death
timeFrame: Up to end of study visit (up to approximately 49 months)
measure: Number of participants with Treatment-emergent adverse events (TEAEs), Treatment-emergent serious adverse events (TESAEs) and Adverse events of special interest (AESI)
timeFrame: Up to approximately 50 months
Other outcomes:
Locations:
city: Huntsville
country: United States
facility: Nephrology Consultants, LLC
state: Alabama
city: Chula Vista
country: United States
facility: Balboa Research SMO+ - Chula Vista - West
state: California
city: El Centro
country: United States
facility: Balboa Research SMO+ - El Centro
state: California
city: Los Angeles
country: United States
facility: University of California, Los Angeles | UCLA Health Division of Nephrology
state: California
city: Poway
country: United States
facility: Balboa Nephrology Medical Group - Poway
state: California
city: S. Gate
country: United States
facility: United Clinical Research & Innovations
state: California
city: San Dimas
country: United States
facility: North America Research Institute - San Dimas
state: California
city: Aurora
country: United States
facility: University of Colorado | Renal Research Office
state: Colorado
city: Middlebury
country: United States
facility: DaVita Clinical Research | Middlebury, CT
state: Connecticut
city: New Haven
country: United States
facility: Yale University | Nephrology Clinical Research
state: Connecticut
city: Waterbury
country: United States
facility: Chase Medical Research, LLC
state: Connecticut
city: Boca Raton
country: United States
facility: Research Physicians Network Alliance
state: Florida
city: Boca Raton
country: United States
facility: Florida Kidney Physicians - Boca Raton
state: Florida
city: Orlando
country: United States
facility: AdventHealth Translational Research Institute
state: Florida
city: Atlanta
country: United States
facility: Grady Memorial Hospital - Endocrinology
state: Georgia
city: Augusta
country: United States
facility: Nephrology Associates, PC | Southeastern Clinical Research Institute, LLC.
state: Georgia
city: Macon
country: United States
facility: Central Georgia Kidney Specialists - Macon
state: Georgia
city: Meridian
country: United States
facility: Frenova Renal Research | Boise Kidney and Hypertension
state: Idaho
city: Chicago
country: United States
facility: Northwestern Medicine - Feinberg School of Medicine - Nephrology and Hypertension
state: Illinois
city: Chicago
country: United States
facility: Research by Design, LLC | Chicago, IL
state: Illinois
city: Hinsdale
country: United States
facility: Nephrology Associates of Northern Illinois and Indiana - Hinsdale
state: Illinois
city: Iowa City
country: United States
facility: University of Iowa Hospitals & Clinics
state: Iowa
city: Kansas City
country: United States
facility: University of Kansas
state: Kansas
city: Wichita
country: United States
facility: Kansas Nephrology Research Institute
state: Kansas
city: Wichita
country: United States
facility: Wichita Nephrology Group, PA
state: Kansas
city: Shreveport
country: United States
facility: Northwest Louisiana Nephrology - Shreveport - 1800 Buckner St.
state: Louisiana
city: Baltimore
country: United States
facility: Johns Hopkins Hospital - Nephrology
state: Maryland
city: Boston
country: United States
facility: Tufts Medical Center | Nephrology Department
state: Massachusetts
city: Edina
country: United States
facility: DaVita Clinical Research | Edina, MN
state: Minnesota
city: Jackson
country: United States
facility: University of Mississippi Medical Center | Shafi Group
state: Mississippi
city: Kansas City
country: United States
facility: Clinical Research Consultants
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis Heart and Vascular, PC - Christian Hospital Office
state: Missouri
city: Albuquerque
country: United States
facility: UNM Clinical and Translational Science Center
state: New Mexico
city: Asheville
country: United States
facility: Mountain Kidney & Hypertension Associates
state: North Carolina
city: Chapel Hill
country: United States
facility: University of North Carolina at Chapel Hill | Nephrology Department
state: North Carolina
city: Greenville
country: United States
facility: East Carolina University | Nephrology & Hypertension
state: North Carolina
city: Wilmington
country: United States
facility: Eastern Nephrology Associates | Wilmington
state: North Carolina
city: Cleveland
country: United States
facility: University Hospitals | UH Cleveland Medical Center - Division of Nephrology & Hypertension Research
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic | Urological and Kidney Department
state: Ohio
city: Bethlehem
country: United States
facility: Northeast Clinical Research Center | Bethlehem, PA
state: Pennsylvania
city: Danville
country: United States
facility: Geisinger Medical Center - Nephrology
state: Pennsylvania
city: Philadelphia
country: United States
facility: Temple Health - Nephrology
state: Pennsylvania
city: Orangeburg
country: United States
facility: South Carolina Clinical Reserach
state: South Carolina
city: Knoxville
country: United States
facility: Knoxville Kidney Center, PLLC
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
city: Dallas
country: United States
facility: Dallas Renal Group - Medical City
state: Texas
city: El Paso
country: United States
facility: El Paso Medical Research Institute (MedResearch Inc) | El Paso, TX
state: Texas
city: Houston
country: United States
facility: DaVita Clinical Research | Houston, TX
state: Texas
city: McAllen
country: United States
facility: Gamma Medical Research, Inc.
state: Texas
city: San Antonio
country: United States
facility: Clinical Advancement Center, PLLC
state: Texas
city: San Antonio
country: United States
facility: University of Texas Health Science Center at San Antonio | Department of Medicine - Division of Nephrology
state: Texas
city: Shenandoah
country: United States
facility: DaVita Clinical Research | North Houston, TX
state: Texas
city: S. Salt Lake
country: United States
facility: Utah Kidney Research Institute | Salt Lake City, UT
state: Utah
city: Salt Lake City
country: United States
facility: University of Utah School of Medicine | Kidney Research Clinic
state: Utah
city: Fairfax
country: United States
facility: Nephrology Associates of Northern Virginia - Fair Oaks
state: Virginia
city: Woodbridge
country: United States
facility: Mendez Center For Clinical Research | Woodbridge, VA
state: Virginia
city: Spokane Valley
country: United States
facility: Providence Medical Research Center
state: Washington
city: Berazategui
country: Argentina
facility: Asociacion de Fomento y Sala de Primeros Auxilios Alberto Mignaburu | Berazategui, Argentina
state: Buenos Aires
city: Ciudad Autónoma de Buenos Aire
country: Argentina
facility: Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina
state: Buenos Aires
city: Lanus
country: Argentina
facility: Centro de Investigaciones Medicas Lanus | Buenos Aires, Argentina
state: Buenos Aires
city: Mar del Plata
country: Argentina
facility: Instituto de Investigaciones Clinicas de Mar del Plata | Mar del Plata, Argentina
state: Buenos Aires
city: Caba
country: Argentina
facility: CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina
state: Ciudad Auton. De Buenos Aires
city: San Luis
country: Argentina
facility: Centro de Rehabilitacion Cardiovascular | San Luis, Argentina
state: Provincia De San Luis
city: Buenos Aires
country: Argentina
facility: Centro de Investigación y Prevención Cardiovascular
city: Córdoba
country: Argentina
facility: Clinica Privada Velez Sarsfield
city: Santa Fe
country: Argentina
facility: Clinica de Nefrologia Urologia y Enfermedades Cardiovascular
city: Santa Fe
country: Argentina
facility: Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina
city: Concord
country: Australia
facility: Concord Repatriation General Hospital
state: New South Wales
city: Kogarah
country: Australia
facility: St George Hospital
state: New South Wales
city: Wollongong
country: Australia
facility: Illawarra Shoalhaven Local Health District
state: New South Wales
city: Birtinya
country: Australia
facility: Sunshine Coast University Hospital
state: Queensland
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital Australia
state: Queensland
city: Reservoir
country: Australia
facility: Melbourne Renal Research Group
state: Victoria
city: St. Albans
country: Australia
facility: Sunshine Hospital
state: Victoria
city: Box Hill
country: Australia
facility: Eastern Health Integrated Renal Service
city: Kortrijk
country: Belgium
facility: AZ Groeninge Campus Kennedylaan | Nephrology
state: West-Vlaanderen
city: Bruxelles - Brussel
country: Belgium
facility: CU Saint-Luc/UZ St-Luc
city: Gent
country: Belgium
facility: UZ Gent
city: Leuven
country: Belgium
facility: UZ Leuven Gasthuisberg
city: Liege
country: Belgium
facility: CHU de Liège
city: Roeselare
country: Belgium
facility: AZ Delta / Nephrology
city: Burgas
country: Bulgaria
facility: Medical Center ''4Life''
city: Dobrich
country: Bulgaria
facility: Viva Phoenix Medical Center | Clinical Trials Department
city: Gorna Oryahovitsa
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment St. Ivan Rilski - Gorna Oryahovitsa | Nephrology Department
city: Montana
country: Bulgaria
facility: Medical Center Hera | Montana Branch
city: Pernik
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Sveti Georgi OOD, Pernik - Department of Cardiology
city: Sofia
country: Bulgaria
facility: Diagnostic-Consultative Center XX | Nephrology Department
city: Stara Zagora
country: Bulgaria
facility: Medical Center Zara-Med EOOD | Nephrology Department
city: Veliko Tarnovo
country: Bulgaria
facility: Medical Center ''Nevromedics''
city: Bengbu
country: China
facility: The First Affiliated Hospital of Bengbu Medical College
state: Anhui
city: Hefei
country: China
facility: The Second Hospital of Anhui medical university
state: Anhui
city: Xiamen
country: China
facility: The First Affiliated Hospital of Xiamen University
state: Fujian
city: Lanzhou
country: China
facility: Lanzhou University Second Hospital
state: Gansu
city: Guangzhou
country: China
facility: Zhujiang Hospital of Southern Medical University
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou University of TCM
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Jinan University
state: Guangdong
city: Huizhou
country: China
facility: Huizhou Central People's Hospital
state: Guangdong
city: Jiangmen
country: China
facility: Jiangmen Wuyi Hospital of traditional Chinese Medicine
state: Guangdong
city: Liuzhou
country: China
facility: Liuzhou Worker's Hospital
state: Guangxi
city: Liuzhou
country: China
facility: People's Hospital of Liuzhou City
state: Guangxi
city: Nanning
country: China
facility: The People's Hospital of Guangxi Zhuang Autonomous Region
state: Guangxi
city: Guiyang
country: China
facility: The Affiliated Hospital of Guizhou Medical University
state: Guizhou
city: Zhangjiakou
country: China
facility: The First affiliated Hospital of Hebei North University
state: Hebei
city: Wuhan
country: China
facility: Wuhan Hospital Of Traditional Chinese And Western Medicine
state: Hubei
city: Wuhan
country: China
facility: Puai Hospital,Tongji Medical College, Huazhong Univ Sci&Tech
state: Hubei
city: Wuhan
country: China
facility: Renmin Hosp., Wuhan Univ.
state: Hubei
city: Baotou
country: China
facility: The First Affiliated Hospital of Baotou Medical College
state: Inner Mongolia
city: Changzhou
country: China
facility: 1st Peopl's Hosp of Changzhou 3rd Affil Hosp of Soochow Univ
state: Jiangsu
city: Huai'An
country: China
facility: Huai'an First People's Hospital, Nanjing Medical University
state: Jiangsu
city: Nanjing
country: China
facility: Zhongda Hospital Southeast University
state: Jiangsu
city: Nanjing
country: China
facility: Jiangsu Province Hospital of Chinese Medicine
state: Jiangsu
city: Nanchang
country: China
facility: The First Affiliated Hospital of NanChang University
state: Jiangxi
city: Pingxiang
country: China
facility: Jiangxi PingXiang people's Hospital
state: Jiangxi
city: Changchun
country: China
facility: The Second Hospital of Jilin University
state: Jilin
city: Siping
country: China
facility: Siping Central Hospital
state: Jilin
city: Dalian
country: China
facility: The First Affiliated Hospital of Dalian Medical University
state: Liaoning
city: Yinchuan
country: China
facility: General Hospital of Ningxia Medical University
state: Ningxia
city: Jinan
country: China
facility: Qilu Hosp., Shandong Univ.
state: Shandong
city: Xi'an
country: China
facility: The First Affiliated Hospital of Xi'an Jiaotong University
state: Shanxi
city: Chengdu
country: China
facility: SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos
state: Sichuan
city: Chengdu
country: China
facility: Sichuan University West China Hospital
state: Sichuan
city: Urumqi
country: China
facility: The First Affiliated Hospital of Xinjiang Medical University
state: Xinjiang
city: Ningbo
country: China
facility: Hwa Mei Hospital, University of Chinese Academy Sciences
state: Zhejiang
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical Univ (New)
state: Zhejiang
city: Beijing
country: China
facility: Beijing Anzhen Hospital, Capital Medical University
city: Beijing
country: China
facility: China-Japan Friendship Hospital
city: Beijing
country: China
facility: Chinese PLA General Hospital
city: Beijing
country: China
facility: Beijing Tsinghua Changgung Hospital
city: Chongqing
country: China
facility: Daping Hospital, 3rd Affil Hosp. 3rd Military Med Univ PLA
city: Shanghai
country: China
facility: Zhongshan Hospital, Fudan University
city: Shanghai
country: China
facility: Xinhua Hos Affiliated to SH Jiaotong Uni School of Medicine
city: Shanghai
country: China
facility: Shanghai Fifth People's Hospital,Fudan University
city: Shanghai
country: China
facility: Central Hospital of Minhang District, Shanghai
city: Tianjin
country: China
facility: Tianjin Union Medicine Centre (People's Hospital of Tianjin)
city: Brno
country: Czechia
facility: Fakultní nemocnice Brno - Interní gastroenterologická klinika
state: Jihomoravsky Kraj
city: Frydek-Mistek
country: Czechia
facility: MUDr.Petr Bucek s.r.o.
city: Hodonin
country: Czechia
facility: CTC Hodonín, s.r.o.
city: Ostrava
country: Czechia
facility: Fakultni nemocnice Ostrava
city: Plzen
country: Czechia
facility: Privamed s.r.o.
city: Praha 2
country: Czechia
facility: Všeobecná fakultní nemocnice v Praze
city: Praha 4
country: Czechia
facility: Nefrologicka ambulance
city: Praha 6
country: Czechia
facility: Nefromed s.r.o.
city: Rychnov nad Kneznou
country: Czechia
facility: Vestra Clinics s.r.o.
city: Znojmo
country: Czechia
facility: Nemocnice Znojmo
city: Copenhagen
country: Denmark
facility: Rigshospitalet, Copenhagen University Hospital | Department of Nefrology
city: Esbjerg
country: Denmark
facility: Hospital of South West Jutland | Department of Endocrinology Research
city: Herlev
country: Denmark
facility: Herlev Hospital | Nephrology Department
city: Herning
country: Denmark
facility: Region Midtjylland | Regionshospitalet Godstrup - Nephrology Department
city: Holbæk
country: Denmark
facility: Region Sjælland | Holbaek Sygehus - Cardiology department
city: Odense C
country: Denmark
facility: Odense University Hospital | Department of Kidney Medicine
city: Arta
country: Greece
facility: General Hospital of Arta | Nephrology Department
city: Athens
country: Greece
facility: HIPPOKRATION General Hospital of Athens
city: Athens
country: Greece
facility: General Hospital of Athens LAIKO
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion - Department of Paediatrics
city: Ioannina
country: Greece
facility: Univ. General Hospital of Ioannina - Department of Paediatrics, Nephrology Unit
city: Patra
country: Greece
facility: University General Hospital of Patras | Nephrology Clinic
city: Pilea Chortiatis
country: Greece
facility: PAPANIKOLAOU General Hospital Thessaloniki
city: Thessaloniki
country: Greece
facility: Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit'
city: Thessaloniki
country: Greece
facility: General Hospital of Thessaloniki Papageorgiou
city: Hong Kong
country: Hong Kong
facility: Prince of Wales Hospital
city: Hong Kong
country: Hong Kong
facility: Princess Margaret Hospital
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
city: Sheung Wan
country: Hong Kong
facility: Tung Wah Hospital
city: Budapest
country: Hungary
facility: Del-pesti Centrumkorhaz - Orszagos Hematologiai és Infektologiai Intezet
city: Kaposvar
country: Hungary
facility: Somogy Varmegyei Kaposi Mor Oktato Korhaz
city: Kistarcsa
country: Hungary
facility: Kistarcsai Flor Ferenc Korhaz
city: Nagykanizsa
country: Hungary
facility: Nagykanizsai Kanizsai Dorottya Korhaz
city: Nyiregyhaza
country: Hungary
facility: Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.
city: Pecs
country: Hungary
facility: Pecsi Tudomanyegyetem Klinikai Kozpont
city: Szombathely
country: Hungary
facility: Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz
city: New Delhi
country: India
facility: Max Super Speciality Hospital, Saket
state: Delhi
city: Ahmedabad
country: India
facility: Mavani Research Center
state: Gujarat
city: Ahmedabad
country: India
facility: Shalby Hospital
state: Gujarat
city: Thiruvananthapuram
country: India
facility: Government Medical College Thiruvananthapuram
state: Kerala
city: Hadapsar
country: India
facility: Noble Hospital
state: Maharashtra
city: Mumbai
country: India
facility: P. D. Hinduja Hospital and Medical Research Centre
state: Maharashtra
city: Nashik
country: India
facility: Shree Siddhivinayak Maternity & Nursing Home
state: Maharashtra
city: Bhubaneswar
country: India
facility: All India Institute of Medical Sciences
state: Odisha
city: Chennai
country: India
facility: Madras Medical College
state: Tamil Nadu
city: Hyderabad
country: India
facility: Osmania General Hospital
state: Telangana
city: Kolkata
country: India
facility: Institute of Post-Graduate Medical Education and Research
state: West Bengal
city: Ashdod
country: Israel
facility: Assuta Ashdod Public Hospital (R.A)
city: Ashkelon
country: Israel
facility: Barzilai Medical Center | Department of Nephrology and Hypertension
city: Beer Sheva
country: Israel
facility: Clalit Health | Soroka Medical Center - Internal Medicine Department
city: Haifa
country: Israel
facility: Rambam Health Corporation
city: Kfar Saba
country: Israel
facility: Meir Medical Center
city: Nahariya
country: Israel
facility: Health Corporation of Galilee Medical Center
city: Petach Tikva
country: Israel
facility: Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department
city: Ramat Gan
country: Israel
facility: Chaim Sheba Medical Center
city: Rehovot
country: Israel
facility: Kaplan Medical Center
city: Tel Aviv
country: Israel
facility: Tel-Aviv Sourasky Medical Center
city: Tiberias
country: Israel
facility: Poria Medical Center | Nephrology and Hypertension Department
city: Zerifin
country: Israel
facility: Shamir Medical Center (Assaf Harofeh)
city: Napoli
country: Italy
facility: A.O.U. Universita' Degli Studi Della Campania Luigi Vanvitelli - Nefrologia
state: Campania
city: Bologna
country: Italy
facility: Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Nefrologia, Dialisi e Trapianto
state: Emilia-Romagna
city: Modena
country: Italy
facility: Azienda Ospedaliero Universitaria di Modena_Policlinico - Nefrologia, Dialisi e Trapianto di Rene
state: Emilia-Romagna
city: Parma
country: Italy
facility: Azienda Ospedaliero Universitaria Parma - SC Nefrologia
state: Emilia-Romagna
city: Reggio Emilia
country: Italy
facility: Azienda USL IRCCS di Reggio Emilia_Arcispedale Santa Maria Nuova - S.C. Nefrologia e Dialisi
state: Emilia-Romagna
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Nefrologia
state: Lazio
city: Bergamo
country: Italy
facility: Istituto Di Ricerche Farmacologiche Mario Negri
state: Lombardia
city: Desio
country: Italy
facility: Azienda Socio Sanitaria Territoriale Della Brianza_Ospedale Pio XI - Nefrologia e Dialisi
state: Lombardia
city: Legnano
country: Italy
facility: Azienda Socio Sanitaria Territoriale Ovest Milanese_Legnano - Nefrologia e Dialisi
state: Lombardia
city: Pavia
country: Italy
facility: Istituti Clinici Scientifici Maugeri S.p.A._Pavia - Nefrologia
state: Lombardia
city: Rho
country: Italy
facility: Azienda Socio Sanitaria Territoriale Rhodense
state: Lombardia
city: Catania
country: Italy
facility: Azienda Ospedaliera Per L'Emergenza Cannizzaro - Nefrologia e Dialisi
state: Sicilia
city: Nagoya
country: Japan
facility: Chubu Rosai Hospital
state: Aichi
city: Nagoya
country: Japan
facility: Daido Clinic
state: Aichi
city: Nagoya
country: Japan
facility: Nagoya City University Hospital
state: Aichi
city: Yatomi
country: Japan
facility: Kainan Hospital
state: Aichi
city: Urayasu
country: Japan
facility: Juntendo University Urayasu Hospital
state: Chiba
city: Iizuka
country: Japan
facility: Aso Iizuka Hospital
state: Fukuoka
city: Kitakyushu
country: Japan
facility: Kokura Memorial Hospital
state: Fukuoka
city: Kitakyushu
country: Japan
facility: JCHO Kyushu Hospital
state: Fukuoka
city: Minokamo
country: Japan
facility: Central Japan International Medical Center
state: Gifu
city: Kobe
country: Japan
facility: Kobe University Hospital
state: Hyogo
city: Nishinomiya
country: Japan
facility: Hyogo Prefectural Nishinomiya Hospital
state: Hyogo
city: Toride
country: Japan
facility: JA Toride Medical Center
state: Ibaraki
city: Tsuchiura
country: Japan
facility: Tsuchiura Kyodo General Hospital
state: Ibaraki
city: Kanazawa
country: Japan
facility: Kanazawa University Hospital
state: Ishikawa
city: Kanazawa
country: Japan
facility: National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office
state: Ishikawa
city: Morioka
country: Japan
facility: Iwate Prefectural Central Hospital
state: Iwate
city: Hiratsuka
country: Japan
facility: Hiratsuka Kyosai Hospital
state: Kanagawa
city: Isehara
country: Japan
facility: Tokai University Hospital
state: Kanagawa
city: Kawasaki
country: Japan
facility: St. Marianna University Hospital
state: Kanagawa
city: Yokohama
country: Japan
facility: Saiseikai Yokohamashi Nanbu Hospital
state: Kanagawa
city: Yokohama
country: Japan
facility: Yokohama City University Hospital
state: Kanagawa
city: Yokohama
country: Japan
facility: Yokohama Sakae Kyosai Hospital
state: Kanagawa
city: Matsumoto
country: Japan
facility: Matsumoto City Hospital
state: Nagano
city: Matsumoto
country: Japan
facility: Shinshu University Hospital
state: Nagano
city: Kurashiki
country: Japan
facility: Kawasaki Medical School Hospital
state: Okayama
city: Sakai
country: Japan
facility: Osaka Rosai Hospital
state: Osaka
city: Irima-gun
country: Japan
facility: Saitama Medical University Hospital
state: Saitama
city: Koshigaya
country: Japan
facility: Koshigaya Municipal Hospital
state: Saitama
city: Hamamatsu
country: Japan
facility: Seirei Hamamatsu General Hospital
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Juntendo University Hospital
state: Tokyo
city: Bunkyo-ku
country: Japan
facility: The University of Tokyo Hospital
state: Tokyo
city: Fuchu
country: Japan
facility: Tokyo Metropolitan Tama Medical Center
state: Tokyo
city: Itabashi-ku
country: Japan
facility: Nihon University Itabashi Hospital
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Medical University Hospital
state: Tokyo
city: Chuo
country: Japan
facility: University of Yamanashi Hospital
state: Yamanashi
city: Fukuoka
country: Japan
facility: Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital
city: Fukuoka
country: Japan
facility: Fukuoka University Hospital
city: Kumamoto
country: Japan
facility: Japanese Red Cross Kumamoto Hospital
city: Nara
country: Japan
facility: Nara Prefecture General Medical Center
city: Saga
country: Japan
facility: Saga-Ken Medical Centre Koseikan
city: Saitama
country: Japan
facility: Japanese Red Cross Saitama Hospital
city: Wonju
country: Korea, Republic of
facility: Yonsei University Wonju Christian Hospital
state: Gang''weondo
city: Anyang-si
country: Korea, Republic of
facility: Hallym University Sacred Heart Hospital
state: Gyeonggido
city: Goyang-si
country: Korea, Republic of
facility: Dongguk University Ilsan Hospital
state: Gyeonggido
city: Goyang-si
country: Korea, Republic of
facility: Inje University Ilsan Paik Hospital
state: Gyeonggido
city: Seongnam-si
country: Korea, Republic of
facility: Bundang Cha Hospital
state: Gyeonggido
city: Incheon
country: Korea, Republic of
facility: The Catholic University of Korea, Incheon St.Mary's Hospital
state: Incheon Gwang''yeogsi
city: Seoul
country: Korea, Republic of
facility: The Catholic Univ. of Korea Eunpyeong St. Mary's Hospital
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Seoul Teugbyeolsi
city: Teugbyeolsi
country: Korea, Republic of
facility: Kangdong Sacred Heart Hospital
state: Seoul
city: Busan
country: Korea, Republic of
facility: Inje University Busan Paik Hospital
city: Daejeon
country: Korea, Republic of
facility: Chung Nam National University Hospital
city: Gyeonggi-do
country: Korea, Republic of
facility: Korea University Ansan Hospital
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital at Gangdong
city: Seoul
country: Korea, Republic of
facility: Seoul National University Boramae Medical Center
city: Seoul
country: Korea, Republic of
facility: Kangnam Sacred Heart Hospital
city: Shah Alam
country: Malaysia
facility: Hospital Selayang
state: Selangor
city: Kedah
country: Malaysia
facility: Hospital Sultan Abdul Halim
city: Kuala Lumpur
country: Malaysia
facility: Hospital Kuala Lumpur
city: Kuala Lumpur
country: Malaysia
facility: University Malaya Medical Centre
city: Muar
country: Malaysia
facility: Hospital Pakar Sultanah Fatimah
city: Negeri Sembilan
country: Malaysia
facility: Hospital Tuanku Jaafar | Nephrology Department
city: Pahang
country: Malaysia
facility: Hospital Tengku Ampuan Afzan
city: Perak
country: Malaysia
facility: Hospital Raja Permaisuri Bainun
city: Perak
country: Malaysia
facility: Hospital Seri Manjung
city: Pulau Pinang
country: Malaysia
facility: Hospital Pulau Pinang
city: Selangor
country: Malaysia
facility: Hospital Kajang
city: Missing
country: Mexico
facility: Fundacion Cardiovascular de Aguascalientes | Aguascalientes, Mexico
state: Aguascalientes
city: Culiacán
country: Mexico
facility: SINACOR | Culiacan, Mexico
state: Sinaloa
city: Puerto de Veracruz
country: Mexico
facility: Sociedad de Metabolismo y Corazon S.C. | Veracruz, Mexico
state: Veracruz
city: Aguascalientes
country: Mexico
facility: Sitio Alfredo Chew Wong | Aguascalientes, Mexico
city: Carnaxide
country: Portugal
facility: Centro Hospitalar de Lisboa Ocidental | Clinical Research Department
state: Lisboa
city: Torres Novas
country: Portugal
facility: Centro Hospitalar do Medio Tejo | Unidade de Torres Novas - Nephrology Department
state: Santarém
city: Almada
country: Portugal
facility: Hospital Garcia de Orta | Research Department
state: Setúbal
city: Leiria
country: Portugal
facility: Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center
city: Lisboa
country: Portugal
facility: Centro Hospitalar Universitario de Lisboa Central | Hospital Curry Cabral - Nephrology Department
city: Arkhangelsk
country: Russian Federation
facility: First City Clinical Hospital n.a. E.E. Volosevich
city: Izhevsk
country: Russian Federation
facility: Izhevsk City Clinical Hospital #9
city: Kemerovo
country: Russian Federation
facility: Kemerovo Regional Clinical Hospital
city: Moscow
country: Russian Federation
facility: City clinical hospital n.a. V.V. Vinogradov
city: Moscow
country: Russian Federation
facility: City Hospital #52
city: Omsk
country: Russian Federation
facility: City Clinical Hospital of Emergency Care #1
city: Rostov-on-Don
country: Russian Federation
facility: Rostov State Medical University
city: Saint-Petersburg
country: Russian Federation
facility: Limited liability company "MK-Med"
city: Saratov
country: Russian Federation
facility: Saratov City Clinical Hospital #9
city: Sestroretsk
country: Russian Federation
facility: City clinical hospital #40 Sestroretsk
city: Voronezh
country: Russian Federation
facility: Voronezh Regional Clinical Consultancy-Diagnostic Center
city: Yaroslavl
country: Russian Federation
facility: Regional Clinical Hospital Yaroslavl
city: Singapore
country: Singapore
facility: National University Hospital Medical Centre
city: Singapore
country: Singapore
facility: Singapore General Hospital
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital
city: Singapore
country: Singapore
facility: SingHealth Polyclinics - Pasir Ris
city: Singapore
country: Singapore
facility: Khoo Teck Puat Hospital
city: Ferrol
country: Spain
facility: Complexo HU Ferrol | Nefrología
state: A Coruña
city: L'Hospitalet de Llobregat
country: Spain
facility: Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Nephrology Department
state: Barcelona
city: Burela
country: Spain
facility: Hospital Publico Da Marina - Nefrologia
state: Lugo
city: Alcalá de Henares
country: Spain
facility: Hospital Universitario Principe De Asturias - Nefrologia
state: Madrid
city: Missing
country: Spain
facility: Hospital Clinico Universitario de Valencia | Nephrology Department
state: Valencia
city: Barcelona
country: Spain
facility: Hospital del Mar | Nephrology Department
city: Barcelona
country: Spain
facility: Ciutat Sanitaria i Universitaria de la Vall d'Hebron
city: Madrid
country: Spain
facility: Hospital Universitario Ramon Y Cajal - Medicina Interna
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre | Department of Nephrology
city: Valencia
country: Spain
facility: Hospital Universitario Dr. Peset
city: Valencia
country: Spain
facility: Hospital Universitario Y Politecnico La Fe - Nefrologia
city: Hsin-Chu
country: Taiwan
facility: National Taiwan University Hospital, Hsin-Chu Branch
state: Hsinchu
city: New Taipei City
country: Taiwan
facility: Far Eastern Memorial Hospital | Nephrology Department
state: Taipei
city: Changhua
country: Taiwan
facility: Changhua Christian Hospital
city: Kaohsiung
country: Taiwan
facility: Chang Gung Memorial Hospital Kaohsiung
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Medical University | Clinical Research Center
city: Taoyuan
country: Taiwan
facility: Chang Gung Memorial Hospital at Linkou
city: Canterbury
country: United Kingdom
facility: Kent and Canterbury Hospital | Renal Research Delivery Team
state: Kent
city: Sheffield
country: United Kingdom
facility: Sheffield Teaching Hospitals NHS Foundation Trust | Northern General Hospital | NIHR Sheffield Clinical Research Facility
state: South Yorkshire
city: Cardiff
country: United Kingdom
facility: Cardiff and Vale University Health Board | University Hospital of Wales - Nephrology and Transplant
city: Gloucester
country: United Kingdom
facility: Gloucestershire Hospitals NHS Foundation Trust | Gloucestershire Royal Hospital - Nephrology
city: London
country: United Kingdom
facility: Barts Health NHS Trust - Royal London Hospital - Nephrology
city: London
country: United Kingdom
facility: King's College Hospital NHS Foundation Trust | King's College Hospital - Nephrology Department
Study officials:
References: