Clinical trial NCT01075425: Belinostat and Bortezomib in Treating Patients With Relapsed or Refractory Acute Leukemia or Myelodysplastic Syndrome
Official title: Phase I Study of Belinostat (PXD-101) and Velcade (Bortezomib) in Relapsed or Refractory Acute Leukemia/ Myelodysplastic Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Acute Lymphocytic Leukemia
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Chronic Myelogenous Leukemia
Keywords: leukemia
acute leukemia
chronic myelogenous leukemia
myelodysplastic syndrome
relapsed acute leukemia
refractory acute leukemia
belinostat
bortezomib
Velcade
PXD-101
Lead sponsor: Virginia Commonwealth University
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2010-02-25
Enrollment: 41
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: RATIONALE: Belinostat and bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving belinostat together with bortezomib may kill more cancer cells. PURPOSE: This phase I trial is studying the side effects and best dose of giving belinostat together with bortezomib in treating patients with relapsed or refractory acute leukemia or myelodysplastic syndrome.

Detailed description: PRIMARY OBJECTIVES: I. To determine the recommended phase II doses for the combination of bortezomib and belinostat in patients with relapsed or refractory acute leukemia (AL), myelodysplasia (MDS), and chronic myelogenous leukemia in blast crisis. SECONDARY OBJECTIVES: I. Determine safety and tolerance and describe the toxicities of the combination. II. To demonstrate adequate methods for the assessment of pharmacodynamic response of leukemia cells from the bone marrow and/or peripheral blood in terms of effects on NF-kB (nuclear RelA by immunofluorescence microscopy), NF-kB dependent proteins XIAP and Bcl-xL, and BIM, and document pharmacodynamic responses observed in the course of this study. III. To document activity of the combination observed in the course of this study. OUTLINE: Patients receive belinostat IV over 30 minutes on days 1-5 and 8-12 and bortezomib IV on days 1, 4, 8, and 11. Treatment repeats every 21 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed periodically.

Eligibility criteria: Inclusion

* Relapsed or refractory acute leukemia
* acute myeloid leukemia (AML) other than APL
* acute lymphocytic leukemia (ALL)
* acute leukemia that has evolved from a prior myelodysplastic syndrome - no requirement for prior therapy
* myelodysplastic Syndrome (MDS) - International Prognostic Scoring System (IPSS) intermediate-2 or greater
* chronic myelogenous leukemia with myeloid or lymphoid blast crisis
* WBC =\< 50 x 10\^9/L; hydroxyurea or leukopheresis may be used prior starting treatment
* Prior allogeneic stem cell transplant is allowed provided that \>/= 12 months have elapsed since allogeneic transplant; no graft versus host disease is present; not currently on immunosuppressive therapy
* AST, ALT =\< 2.5 x upper limit of normal (ULN)
* Female subject who is post-menopausal or surgically sterilized or willing to use an acceptable method of birth control (i.e., oral or injectable hormonal methods; barrier methods such as intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) for the duration of the study
* Male subject agrees to use an acceptable method for contraception for the duration of the study
* Serum total bilirubin =\< 1.5 x upper limit of normal
* Serum potassium \>= 3.5 mEq/L and serum magnesium \>= 1.7 mEq/dL (electrolytes may be corrected with supplementation)
* ECOG Performance Status (PS) =\<2
* Creatinine =\< 1.5 x upper limit of normal or calculated or actual creatinine clearance \> 45 mL/min

Exclusion

* Willing and medically suitable for remission induction with other agents in anticipation of a potentially curative allogeneic bone marrow transplant
* Known CNS malignant disease
* Prior severe allergic reactions to bortezomib, mannitol, boron, belinostat or compounds of the hydroxamate class or arginine
* Grade 1 with pain or Grade \>= 2 peripheral neuropathy or paresthesias within 14 days before enrollment
* History of sustained ventricular tachycardia, ventricular fibrillation, Torsade de Pointes, or resuscitated cardiac arrest

  • History of resuscitated cardiac arrest. Note: persons without pre-existing cardiovascular comorbidities who have experienced resuscitated cardiac arrest in the setting of sepsis ARE eligible provided they have no residual cardiac abnormalities and providing they do not require ongoing medication to manage cardiac issues as an outcome of such an event.
* Conduction abnormality or concomitant treatment with an anti-arrhythmic agent to prevent or control arrhythmia
* Known congenital long QT syndrome
* Clinically significant infection including infection with HIV, or active hepatitis B or C
* Significant cardiovascular disease, hypertrophic cardiomegaly or restrictive cardiomyopathy, myocardial infarction within the past 6 months, unstable angina
* Baseline QTc interval \> 450 msec
* Planned or ongoing treatment with any drug that may be risk of causing Torsades de Pointes
* Persistent blood pressure (BP) of \>=160/95
* Serious medical or psychiatric illness likely to interfere with patient participation
* Pregnant or nursing
* Diagnosis or treatment for another malignancy within 3 years of enrollment, with the exception of complete resection of basal cell carcinoma or squamous cell carcinoma of the skin, an in situ malignancy, or low risk prostate cancer after curative therapy
* Planned ongoing treatment with other drugs thought to potentially adversely interact with belinostat
* Strong or moderate CYP3A4 inhibitors
* Patient has received other investigational drugs within 14 days before enrollment
* If steroids for cancer control have been used, patients must be off these agents for \>/= 1 week before starting treatment. Exception: maintenance therapy for non-malignant disease with prednisone or steroid equivalent dose \< 10 mg/day is permitted.

Primary outcomes:
measure: Recommended phase II doses for the combination of bortezomib and belinostat
timeFrame: 2 years
Secondary outcomes:
measure: Toxicity
timeFrame: 2 years
measure: Pharmacodynamic response
timeFrame: 2 years
measure: Activity of belinostat and bortezomib
timeFrame: 3 years
Other outcomes:
Locations:
city: Houston
country: United States
facility: M D Anderson Cancer Center
state: Texas
city: Richmond
country: United States
facility: Virginia Commonwealth University
state: Virginia
Study officials:
affiliation: Virginia Commonwealth University
name: Steven Grant
role: STUDY_CHAIR
affiliation: Massey Cancer Center
name: Beata Holkova, MD
role: PRINCIPAL_INVESTIGATOR
References: