louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05246722: Registry Study of Pharmacotherapy and Clinical Outcomes in Elderly Patients With Coronary Heart Disease (PHARM-ageing)
Official title: Registry Study of Pharmacotherapy and Clinical Outcomes in Elderly Patients With Coronary Heart Disease
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Elderly Patients
Coronary Heart Disease
Drug Therapy
Clinical Outcomes
Lead sponsor: Beijing Anzhen Hospital
Sponsor class: OTHER
First posted: 2022-02-18
Enrollment: 15000
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Elderly patients (≥65 years) with coronary heart disease who discharged at Beijing Anzhen Hospital from January 1, 2019.Those who fill the inclusion criteria at screening will be invited for the registry study.

Brief summary: A registry study on drug therapy and clinical outcomes in elderly patients with coronary heart disease


Eligibility criteria: Inclusion Criteria:

* Informed consent has been signed
* Patients diagnosed in our hospital with coronary heart disease
* Age ≥65 years

Exclusion Criteria:

* Severe lack of important information such as history of previous medication, history of previous disease, history of surgery.
* Mental disorders, or inability to communicate effectively with researchers, or failure to comply with research protocols.

Primary outcomes:
measure: main adverse cardiovascular and cerebrovascular events (MACCE)
timeFrame: up to 3 years
Secondary outcomes:
measure: Adverse drug reaction
timeFrame: up to 3 years
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00172822: Appendicitis With Medical Treatment
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Appendicitis
Keywords: appendicitis
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2005-09-15
Enrollment: 80
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: NATURAL_HISTORY
Time perspective: PROSPECTIVE

Brief summary: prospective study to collect data of patients with appendicitis, not receiving operation

Detailed description: using ultrasound to follow up the resolution of acute appendicitis

Eligibility criteria: Inclusion Criteria:patients with appendicitis, not receiving operation -

Exclusion Criteria:nil

-

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Lien
Study officials:
affiliation: NTUH
name: Wan-Ching Lien, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01994122: Mental Health and Resilience in Emerging Adulthood
Official title: Mental Health and Resilience in Emerging Adulthood
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Depression
Anxiety
Personality Disorders
Lead sponsor: University of Tromso
Sponsor class: OTHER
Collaborators: name: Harstad University College
First posted: 2013-11-25
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects 18-25 years old who have dropped out of school and who are currently unemployed

Brief summary: The purpose of this study is to examine differences in selected psychiatric/psychological variables between a sample of unemployed young adults who have dropped out of high school and a sample of college students.


Eligibility criteria: Inclusion Criteria:

* Subjects 18-25 years old who have dropped out of school and who are currently unemployed

Exclusion Criteria:

-

Primary outcomes:
measure: Prevalence of axis-1 disorders in the sample.
timeFrame: Within 6 months of enrolment
Secondary outcomes:
Other outcomes:
Locations:
city: Harstad
country: Norway
facility: Harstad University Colle
Study officials:
affiliation: University of Tromsø, Norway
name: Rolf Wynn, ph.d.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01237522: A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers
Official title: A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Metformin
Organic Cation Transporter 2
Polymorphism,Single Nucleotide
Keywords: Diabetes Mellitus, Type 2
Metabolic Clearance Rate
Pharmacokinetics
Pharmacogenetics
Lead sponsor: University of Southern Denmark
Sponsor class: OTHER
First posted: 2010-11-09
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The aim of the study is to evaluate the pharmacokinetics of metformin in healthy Caucasians volunteers with and without the polymorphism A270S in OCT2,thus the study hypothesis is that renal clearance of metformin is affected in Caucasian with the known single nucleotide polymorphisms A270S in OCT2.


Eligibility criteria: Inclusion Criteria:

* Healthy volunteers
* Written consent
* rs316019 genotyped
* Age 18-65 years old

Exclusion Criteria:

* Daily medication
* Alcohol abuse
* Pregnancy
* Breastfeeding

Primary outcomes:
measure: Renal clearance of metformin
timeFrame: 24 Hours
Secondary outcomes:
Other outcomes:
Locations:
city: Odense
country: Denmark
facility: Institute of Public Health, Clinical Pharmacology, University of Southern Denmark
Study officials:
affiliation: University of Southern Denmark
name: Kim Broesen, Professor
role: STUDY_CHAIR
References:
Clinical trial NCT00980122: Aggressiveness of Care at the End of Life in Cancer Patients
Official title: Aggressiveness of Care at the End of Life in Cancer Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Advanced Cancer
Keywords: Advanced cancer patients dying in hospital receive aggressive cancer-specific therapy and supportive measures.
Lead sponsor: National University Hospital, Singapore
Sponsor class: OTHER
First posted: 2009-09-18
Enrollment: 250
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: All advanced cancer patients who passed away in the National University Hospital during a defined 1 year period, will have a retrospective review of paper and electronic records.

Study subjects are identified from the weekly mortality lists that are sent to the Department of Haemtology Oncology. We aim to include 250 patients in this retrospective study.

Brief summary: Cancer is the commonest cause of death in Singapore, and many cancer deaths occur in hospital.

Management of cancer patients is getting more complex with constant development of new drugs, interventional procedures and supportive measures. Despite this, the majority of advanced cancer patients will die from their disease or related complications.

There is a lack of data on the utilisation of health resources in advanced cancer patients in this country. In this study the investigators ask themselves how aggressive care was in the last 3 months of the patient's life. The investigators will be collecting data on specific cancer treatments, interventional procedures, and supportive measures.


Eligibility criteria: Inclusion Criteria:

* Advanced cancer patients who passed away as an inpatient in NUH, under the department of Haematology Oncology.

Exclusion Criteria:

* Patients with haematologic malignancies.

Primary outcomes:
measure: To describe the trends in the aggressiveness of care for advanced cancer patients near the end of life.
Secondary outcomes:
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: National University Hospital
Study officials:
References:
citation: Braga S, Miranda A, Fonseca R, Passos-Coelho JL, Fernandes A, Costa JD, Moreira A. The aggressiveness of cancer care in the last three months of life: a retrospective single centre analysis. Psychooncology. 2007 Sep;16(9):863-8. doi: 10.1002/pon.1140.
citation: Cintron A, Hamel MB, Davis RB, Burns RB, Phillips RS, McCarthy EP. Hospitalization of hospice patients with cancer. J Palliat Med. 2003 Oct;6(5):757-68. doi: 10.1089/109662103322515266.
Clinical trial NCT05678322: Optimizing Timing of rhPSMA-7.3 (18F) for Assessing Site(s) of Recurrent Disease Following Radical Prostatectomy
Official title: Optimizing Timing of rhPSMA-7.3 (18F) for Assessing Site(s) of Recurrent Disease Following Radical Prostatectomy
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Prostate Cancer
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
Collaborators: name: Blue Earth Diagnostics
First posted: 2023-01-10
Enrollment: 26
Sex: MALE
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: All men following Radical Prostatectomy (RP) at NYU Langone Health undergo routine prostate specific antigen (PSA) testing in order to identify disease recurrence. By consensus, a BCR following RP occurs once the PSA \> 0.2 ng/ml/ Biochemical recurrence often develops years prior to clinical evidence of disease recurrence. Early identification of the site(s) of disease recurrence enables early salvage intervention. Men will be eligible for the study at the point in time their post-prostatectomy PSA level first becomes \>0.2 ng/ml. Only those patients with rhPSMA-7.3 (18F) identifiable disease (local, nodal or systemic) will be offered salvage intervention per standard of care. All patients with a negative initial rhPSMA-7.3 (18F) scan will undergo a second scan when the PSA is \> 0,5 ng/ml or one year after the initial PET study. The salvage interventions will be at the discretion of the investigator. The study will compare the diagnostic yield of the first and second rhPSMA-7.3 (18F) studies.


Eligibility criteria: Inclusion Criteria:

Eligible patients will include all men between age 18 -100 years old,-that have had RP, at the first point in time the PSA \> 0.2 ng/ml.

Exclusion Criteria:

* Any contraindication for MRI imaging.
* Prior allergic reaction to rhPSMA-7.3 (18F).
* Patient refuses rhPSMA-7.3 (18F) PET/MRI.

Primary outcomes:
measure: Change from Baseline in Percentage of Positive PCa Screens
timeFrame: Baseline, Up to Month 24
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Smilow Comprehensive Prostate Cancer Center
state: New York
Study officials:
affiliation: NYU Langone Medical Center
name: Herbert Lepor, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01171222: Health Status and Cardiovascular Stress of Veteran Soccer Players
Official title: Health Status and Cardiovascular Stress of Veteran Soccer Players
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Health Status
Stress
Keywords: soccer
prevention
veteran athletes
exercise
Cardiovascular
Lead sponsor: Universität des Saarlandes
Sponsor class: OTHER
First posted: 2010-07-28
Enrollment: 100
Sex: MALE
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: veteran soccer players from Saarland County, Germany

Brief summary: This study shall provide missing descriptive data on health status of veteran players and potential preventive effects of soccer at an age of 40 to 60 years. The investigation represents a cross-sectional examination of cardiovascular parameters and metabolic stress induced by training and competition. Additionally, orthopedic and other medical risks are to be revealed, and options should be developed to minimize these risks, e.g. by preventive measures included in training or rule modifications.

Detailed description: Facing the demographic trends in Western societies there is an expected increase in interest in soccer for males between 40 and 60 years. Positive effects of such an activity on health can be suspected based on some studies and analogous conclusions. However, no sufficient database is available yet. Moreover, the range of cardiovascular risk factors or pre-existing diseases for this specific population is not known.

This study shall provide missing descriptive data on health status of veteran players and potential preventive effects of soccer at an age of 40 to 60 years. The investigation represents a cross-sectional examination of cardiovascular parameters and metabolic stress induced by training and competition. Additionally, orthopedic and other medical risks are to be revealed, and options should be developed to minimize these risks, e.g. by preventive measures included in training or rule modifications.

Eligibility criteria: Inclusion Criteria:

* Male veteran soccer players aged 40 years and older, who are member of a club veteran team

Exclusion Criteria:

* Diseases or injuries which are contraindications for physical exercise

Primary outcomes:
measure: Descriptive data from medical check up and physiological testing
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Saarbrücken
country: Germany
facility: Saarland University
state: Saarland
Study officials:
affiliation: Universität des Saarlandes
name: Tim Meyer, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02485522: Diet and Stool Metabolites in Fecal Incontinence
Official title: Diet and Stool Metabolites in Women With Fecal Incontinence
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fecal Incontinence
Keywords: fecal incontinence
diet
nutrition
metabolites
stool
FI
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
First posted: 2015-06-30
Enrollment: 28
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women with fecal incontinence from an outpatient GYN clinic.

Brief summary: Fecal Incontinence (FI) is a debilitating and common condition with a prevalence ranging from 7-15% in community dwelling women. FI has an immense impact on quality of life and is associated with increased care giver burden, increased rates of institutionalization, and significant cost burden in older women. Traditionally believed to be primarily caused by child birth injury, recent studies show that the typical age of onset of FI is age 40 which is remote from child birth. Treatment options for FI are limited because the mechanism underlying FI in older women are poorly understood. The overriding goal of this project is to investigate the relationship between diet, stool metabolites and fecal incontinence.


Eligibility criteria: Inclusion Criteria:

* Age greater than 18,
* parous women with fecal incontinence (defined as any uncontrolled loss of liquid or solid fecal material that occurs at least monthly over the last 3 months that is bothersome enough to desire treatment),
* current negative colon cancer screening

Exclusion Criteria:

* Current bloody diarrhea,
* current or past diagnosis of colorectal or anal malignancy,
* diagnosis of inflammatory bowel disease,
* recent antibiotic treatment,
* history of immune deficiency diseases,
* history of recent treatment with immune suppressant medications.

Primary outcomes:
measure: Stool butyrate levels
timeFrame: within 1 week of collection
measure: Pattern of dietary intake by indicator
timeFrame: 1 year
Secondary outcomes:
measure: Stool levels of global metabolites
timeFrame: within 1 week of collection
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Hospital of the University of Pennsylvania
state: Pennsylvania
Study officials:
References:
Clinical trial NCT03130322: SLeep and IMagery Correlates (SOMMEIL-IMAGERIE)
Official title: Neurophysiological Correlates of Sleep Motor Consolidation Following Motor Imagery Practice
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2017-04-26
Enrollment: 51
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study is designed to determine the neural networks underlying the sleep-related motor consolidation process following motor imagery practice. While beneficial effects of sleep are expected for sequential movement but not for adaptation motor tasks, the corresponding neuroanatomical correlates have not yet been investigated when participants acquired the motor tasks through mental practice. Data should substantially promote how designing motor imagery interventions targeting (re)learning and/or motor recovery in patients suffering from motor disorders.


Eligibility criteria: Inclusion Criteria:

* Healthy right-handed persons without neurologic disease
* Persons having signed informed consent for a neuroimagery study

Exclusion Criteria:

* Persons under curatorship or any administrative/judicial measure
* Participants refusing to be informed of the results of the experiment
* Pregnant women
* Participants with contraindications to the MEG examination: head size, presence of a neurostimulator, steel pivot for the root canal, metallic fragments, ear implants, metal screws in the body or mouth.
* Persons using a pacemaker, insulin pump, or working regularly with iron filings
* Claustrophobic persons

Primary outcomes:
measure: Evidence of MEG correlates of sleep motor consolidation (day 1)
timeFrame: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
measure: Evidence of MEG correlates of sleep motor consolidation (day 2)
timeFrame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Secondary outcomes:
measure: Time needed to complete the motor tasks (day 1)
timeFrame: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
measure: Evidence of MEG correlates of sleep motor consolidation
timeFrame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
measure: Accuracy of the motor tasks
timeFrame: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
measure: Time needed to complete the motor tasks
timeFrame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
measure: Accuracy of the motor tasks 2
timeFrame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Other outcomes:
Locations:
city: Bron
country: France
facility: CH le Vinatier
Study officials:
affiliation: CH le Vinatier
name: Alain Nicolas, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01580722: Comparison of Early Versus Delay Reconstruction in Anterior Cruciate Ligament Tearing
Official title: Study of Surgical Methods for Anterior Cruciate Ligament Tearing
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Anterior Cruciate Ligament Tear
Keywords: Anterior Cruciate Ligament,Early,Delay,Reconstruction
Lead sponsor: Isfahan University of Medical Sciences
Sponsor class: OTHER
First posted: 2012-04-19
Enrollment: 202
Sex: ALL
Minimum age (years): 18
Maximum age (years): 36
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine which surgical method is better for anterior cruciate ligament teas in outcomes.

Detailed description: The anterior cruciate ligament (ACL) is one of the most commonly injured ligaments of the knee. This study was conducted to determine whether the outcome of treatment is superior in early surgical reconstruction compared with optional delay reconstruction.

Eligibility criteria: Inclusion Criteria:

a. patients with confirmed anterior cruciate ligament tearing

Exclusion Criteria:

One of the following associated injuries to the index knee as visualized on MRI and/or arthroscopy:

1. An unstable longitudinal meniscus tear that requires repair and where the following postoperative treatment (i.e. bracing and limited ROM) interferes with the rehabilitation protocol
2. Bi-compartmental extensive meniscus resections
3. A cartilage injury representing a full thickness loss down to bone
4. A total rupture of MCL/LCL as visualized on MRI

Primary outcomes:
measure: quality of life
timeFrame: at 6 months post-operatively
Secondary outcomes:
measure: Tegner activity score
timeFrame: at 6 months post-operatively
measure: Knee injury and Osteoarthritis Outcome Score
timeFrame: at 6 months post-operatively
Other outcomes:
Locations:
city: Isfahan
country: Iran, Islamic Republic of
facility: Al-zahra university hospital
Study officials:
affiliation: MD,research comittee
name: hamidreza shemshaki, MD
role: STUDY_CHAIR
References:
Clinical trial NCT04501822: One-year Cardiac Follow-up of Patients With COVID-19 Pneumonia
Official title: One-year Cardiac Follow-up of Patients With COVID-19 Pneumonia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
Cardiac Complication
Keywords: Covid19
Cardiovascular Disease
Echocardiography
Lead sponsor: Tomsk National Research Medical Center of the Russian Academy of Sciences
Sponsor class: OTHER
First posted: 2020-08-06
Enrollment: 380
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study includes men and women ≥18 years old with documented COVID-19 pneumonia

Brief summary: The primary objective of the study is to assess the cardiac status of COVID-19 pneumonia patients during 1 year after discharge

Detailed description: Although COVID-19 manifests in most cases with respiratory symptoms, cardiovascular abnormalities is common in hospitalized patients. Patients with cardiovascular risk factors or established disease appear to have a worse prognosis. Myocardial dysfunction could be a direct manifestation of COVID-19. The investigators hypothesize that subjects after COVID-19 pneumonia present myocardial and vascular remodeling during 1 year after discharge, even in the absence of prior cardiovascular disease.

Eligibility criteria: Inclusion Criteria:

-Patients with documented COVID-19 pneumonia

Exclusion Criteria:

* Patients with cancer
* Impossible to follow up

Primary outcomes:
measure: Echocardiographic assessment of cardiac function
timeFrame: up to one year
Secondary outcomes:
measure: МАССЕ
timeFrame: up to one year
measure: Quantitative analysis of parenchymal lung damage
timeFrame: up to one year
measure: Functional exercises capacity assessment
timeFrame: up to one year
measure: Evaluation of renal function
timeFrame: up to one year
measure: Evaluation of inflammation
timeFrame: up to one year
measure: Evaluation of coagulation abnormality
timeFrame: up to one year
measure: Evaluation of quality of life in first year after discharge
timeFrame: up to one year
Other outcomes:
Locations:
city: Tyumen
country: Russian Federation
facility: Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science
Study officials:
affiliation: Tyumen Cardiology Research Center
name: Elena Yaroslavskaya, PhD
role: PRINCIPAL_INVESTIGATOR
References: