louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02699216: BioCurrent Electrical Stimulation for the Treatment of Dry ARMD
Official title: BioCurrent Electrical Stimulation for the Treatment of Dry Age-Related Macular Degeneration
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Dry Macular Degeneration
Keywords: Macular Degeneration
Eye Diseases
Retinal Degeneration
Retinal Diseases
Lead sponsor: DuBois Vision Clinic
Sponsor class: OTHER
First posted: 2016-03-04
Enrollment: 0
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This study evaluates the treatment of Dry Macular Degeneration and the resulting change in vision with a very, very low current that is similar to what occurs in the body naturally. In Phase 1, 16 participants will be treated, with half receiving treatment and half a sham (no treatment). After the treatment period of one week, those not treated will be treated. In Phase 2, all participants will be treated.

Detailed description: The study will assess the effectiveness of transpalpebral micro-current electrical stimulation on improving the visual acuity in subjects with vision loss from Dry Macular Degeneration. The BioCurrent electrical stimulation will be applied by a device with the intended use of treating Dry Macular Degeneration. The device delivers a micro-current, an electrical current in the one millionth of an ampere range, to the retina in frequencies changing in a pre-defined pattern from 5Hz to 80Hz during each spot (40 sec). The device also incorporates a voltage limiter (a maximum of 245 micro A is possible) and a current level indicator. 200 micro A will be used. Very low electrical micro-current is delivered to the subject through the goggle probe.

Eligibility criteria: Inclusion Criteria:

* Best-corrected visual acuity can be no better than 20/40 and no worse than 20/200 for each enrolled eye
* Confirmed diagnosis of Dry MD
* Vision loss attributable to Dry MD
* Subjects must be highly motivated, alert, oriented, mentally competent and able to understand and comply with the requirements of the study, abide by the restrictions, return for all required visits, and provide voluntary informed consent

Exclusion Criteria:

* Any retinal pathology other than Dry MD
* Evidence or history of wet MD
* Previous intravitreal injection
* Seizure disorders
* Dense cataract
* Eyelid pathology at the treatment sites
* Any prior electrical micro-stimulation treatment to the eyes
* Poor general health
* Active cancer
* Life expectancy less than 12 months
* Non-ambulatory
* Not considered suitable for participation for any other reason

Primary outcomes:
measure: Change in Best-corrected Visual Acuity using the Early Treatment of Diabetic Retinopathy Study (ETDRS) chart
timeFrame: Baseline, Day 5
Secondary outcomes:
measure: Changes in retinal sensitivity assessed by Microperimetry
timeFrame: Baseline, Day 5
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00173316: Expression of VEGF-C and VEGF-CR in Oral Cancers and Premalignant Lesions
Official title: The Role of Vascular Endothelial Growth Factor-C (VEGF-C) and Its Receptors Induced Lymphangiogenesis on the Carcinogenesis of Oral Cancers and Premalignant Lesions
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Oral Cancer
Keywords: vascular endothelial growth factor-C
VEGF-CR
lymphangiogenesis
host inflammatory responses
oral carcinogenesis
oral cancers
oral premalignant lesions
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2005-09-15
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: DEFINED_POPULATION
Time perspective: RETROSPECTIVE

Brief summary: The role of vascular endothelial growth factor-C (VEGF-C) and its receptors induced lymphangiogenesis and host inflammatory responses on the carcinogenesis of oral cancers and premalignant lesions

Detailed description: The role of vascular endothelial growth factor-C (VEGF-C) and its receptors induced lymphangiogenesis and host inflammatory responses on the carcinogenesis of oral cancers and premalignant lesions

Eligibility criteria: Inclusion Criteria:

* oral cancer and oral precancer specimens

Exclusion Criteria:

* other diseases

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan university
Study officials:
affiliation: National Taiwan University
name: Chun-Pin Chiang, DMSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03800316: Synchronous Video (Telemedicine) Consulation in the Prehospital Setting
Official title: Synchronous Video (Telemedicine) Consulation in the Prehospital Setting
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Emergencies
Prehospital
Telemedicine
Telehealth
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2019-01-11
Enrollment: 85
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The study team aims to test connectivity metrics and follow patient outcomes using a new, innovative synchronous video technology in the prehospital setting in three distinct areas:

1. - 911 Calls
2. - Pediatric Critical Care Transport

Currently, paramedics and pediatric transport teams seek advice from physicians using a telephone. This project replaces the phone with video consultation where the physicians can directly interact with patients, paramedics and transport teams when care advice is needed.


Eligibility criteria: Inclusion Criteria:

* Cardiac Arrest
* Hemodynamically unstable trauma patients requiring resuscitation and airway management
* Trauma patients with altered mentation requiring airway management
* Acute stroke patients
* Medical patients that refuse transport for medical evaluation Pediatric Intensive Care Telemedicine Program
* Complex clinical situations where paramedic teams need immediate management guidance
* Critically ill pediatric patients requiring evaluation/stabilization for interfacility transport
* Pediatric patients requiring intervention for respiratory failure
* Pediatric patients with ongoing seizures and/or neurological abnormalities
* Hemodynamically unstable patients
* Complex clinical situations requiring medical control guidance

Exclusion Criteria:

• All other patients not list above

Primary outcomes:
measure: Video Consultations Completed
timeFrame: 1 year
Secondary outcomes:
measure: Mortality
timeFrame: 1 year
measure: Hospital Length of Stay
timeFrame: 1 year
measure: Emergency Room Length of Stay
timeFrame: 1 year
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Christopher S Russi
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04121416: Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery
Official title: Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiovascular
Keywords: Oxycodone
Sufentanil
tracheal intubation
Lead sponsor: Shengjing Hospital
Sponsor class: OTHER
First posted: 2019-10-09
Enrollment: 50
Sex: FEMALE
Minimum age (years): 60
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).

Detailed description: Laryngoscopy and tracheal intubation can provoke an increase of blood pressure (BP) and/or HR \[1.2\]. This hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. Thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.

Eligibility criteria: Inclusion Criteria:

The coronary angiography from each patient showed that lesions exist in at least one main coronary artery

Exclusion Criteria:

a history of reactive airway disease, gastroesophageal reflux, morbid obesity, a known or predicted difficult airway

Primary outcomes:
measure: blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP)
timeFrame: one second before anesthesia induction, the moment when tracheal catheter passes through glottis and at 1, 3, 5 min after tracheal intubation
Secondary outcomes:
Other outcomes:
Locations:
city: Shenyang
country: China
facility: shengjing hospital of China medical university
state: Liao Ning
Study officials:
affiliation: Shengjing Hospital
name: Junchao Zhu
role: STUDY_DIRECTOR
References:
Clinical trial NCT00329316: Prevention of Recurrent Preterm Delivery by a Natural Progesterone Agent
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Pregnancy
Premature Birth
Keywords: Pre-term labor
progesterone
Lead sponsor: The Baruch Padeh Medical Center, Poriya
Sponsor class: OTHER_GOV
First posted: 2006-05-24
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: To examine the preterm delivery rate of a preterm delivery high risk group of pregnant women, using once daily natural progesterone agent.


Eligibility criteria: Inclusion Criteria:

Pregnancy 24 weeks' gestation Preterm labor in previous pregnancies

-

Exclusion Criteria:

* No medications for PTL or any kind of progesterone.
* Cervical suture
* Multiple pregnancy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: The Baruch Padeh Medical Center, Poriya
name: Yuri Perlitz, MD
role: STUDY_CHAIR
affiliation: Head of Obs/Gyn ,The Baruch Padeh Medical center, Poriya
name: Mosheh Ben Ami, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05080816: Effects of Parenteral and Enteral Nutrition on Skeletal Muscle Genomics
Official title: Effects of Parenteral and Enteral Nutrition on Skeletal Muscle Genomics
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Loss
Keywords: Skeletal muscle
Lead sponsor: Göteborg University
Sponsor class: OTHER
First posted: 2021-10-18
Enrollment: 39
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The study investigates effects related to muscle protein metabolism at provision of Parenteral or enteral nutrition

Detailed description: Randomized study investigation alterations in muscle protein metabolism at provision of parenteral or enteral (oral drink) nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis and protein degradation. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.

Eligibility criteria: Inclusion Criteria:

* Major gastrointestinal surgery.
* Assumed need of post-operative nutrition support.

Exclusion Criteria:

* Insulin dependent diabetes.
* Steroid medication.

Primary outcomes:
measure: Muscle protein metabolism
timeFrame: ~12-14 hours.
Secondary outcomes:
Other outcomes:
Locations:
city: Gothenburg
country: Sweden
facility: Sahlgrenska University Hospital
state: Region Västra Götaland
Study officials:
affiliation: Göteborg University
name: Britt-Marie Iresjö, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02135016: The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Induction
Official title: The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Concentration During General Anesthesia Induction
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Target Controlled Infusion (TCI)
Thoracic Epidural Anesthesia
Block Level
Gastrointestinal Surgery
Keywords: effect-site concentration
propofol
thoracic epidural anesthesia
Lead sponsor: First Hospital of China Medical University
Sponsor class: OTHER
First posted: 2014-05-09
Enrollment: 45
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: It is a prospective, randomized, placebo-controlled study to investigate the effect of TEA with different block level on propofol concentration during general anesthesia induction.


Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists (ASA) I-II physical status,
* aged 40-60 yr,
* BMI 19-25 kg/m2,
* undergoing elective gastrointestinal surgery

Exclusion Criteria:

* patients with cardiovascular or neurological disease, drug or alcohol abuse and absolute contraindications for neuraxial blockade.

Primary outcomes:
measure: The Effect-site Concentration of Propofol
timeFrame: The participants will be followed for the duration of anesthesia induction, an expected average of half an hour
Secondary outcomes:
measure: The Bispectral Index
timeFrame: The participants will be followed for the duration of anesthesia induction, an expected average of half an hour
measure: The Mean Blood Pressure
timeFrame: The participants will be followed for the duration of anesthesia induction, an expected average of half an hour
measure: The Heart Rate
timeFrame: The participants will be followed for the duration of anesthesia induction, an expected average of half an hour
measure: The Block Level of Epidural Anesthesia
timeFrame: 20 mins after epidural anesthesia
Other outcomes:
Locations:
city: Shenyang
country: China
facility: Jun Wang
state: Liaoning
Study officials:
affiliation: Dept. of Anesthesiology, First Affiliated Hospital of China Medical University
name: Jun Wang, professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT01084616: Vaginal Microbiota Among Postmenopausal Women
Official title: The Role of Vaginal Microbiota in Symptoms of Vaginal Dryness in Postmenopausal Women
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Vulvovaginal Atrophy
Lead sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sponsor class: OTHER
First posted: 2010-03-10
Enrollment: 16
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Postmenopausal women

Brief summary: It is known that vaginal bacteria have an impact upon the health status of the host, in some cases protecting against infection and in other cases causing infection, depending on the bacterial types present. This study will compare the composition of vaginal bacteria to symptoms of vaginal dryness in order to try and identify if certain bacteria might cause some of the problems associated with vaginal dryness among post-menopausal women.


Eligibility criteria: Inclusion Criteria:

* Between 30 and 80 years old.
* Postmenopausal = 12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum FSH levels \> 40 mIU/ml or 6 weeks postsurgical bilateral oophorectomy with or without hysterectomy.
* Prepared not to take hormone replacement therapy during 8 weeks follow-up and not taking estrogen alone or estrogen/progestin containing drug products at the time of screening.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: London
country: Canada
facility: Victoria Family Medical Center
state: Ontario
Study officials:
affiliation: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
name: Gregor Reid, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06960616: Improving Clinical Efficiency by Reducing Scheduled Follow-ups Using Cochlear America's Population Mean Mapping Strategy
Official title: Improving Clinical Efficiency by Reducing Scheduled Follow-ups Using Cochlear America's Population Mean Mapping Strategy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Deafness
Cochlear Hearing Loss
Lead sponsor: Massachusetts Eye and Ear Infirmary
Sponsor class: OTHER
Collaborators: name: Cochlear
First posted: 2025-05-07
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study is about the importance of each follow-up visit after activating a new cochlear implant in addition to evaluating the effectiveness and efficiency of a new programming strategy from Cochlear Americas. Investigators are looking for patients who have recently selected Cochlear Americas as their cochlear implant manufacturer of choice for their upcoming surgery. The aim of this study is to determine if 1) patient outcomes remain stable when reducing follow-up appointments and 2) Cochlear's population mean mapping can produce similar outcomes with patients while additionally reducing appointment times. The hypothesis is that using population mean mapping and reducing the number of follow-up visits after activation will yield similar performance outcomes to a standard of care while decreasing the length of appointment times and number of appointments needed for each patient.


Eligibility criteria: Inclusion Criteria:

* Postlingually deafened
* Adults (18+)
* New cochlear implant recipients with Cochlear Americas devices; identified prior to activation
* Able to perform follow-up testing tasks (repeating words/sentences, indicating they heard a sound stimulus, completing questionnaires)
* English speakers

Exclusion Criteria:

* Patients who select other cochlear implant manufactured devices
* Pre-lingually deafened
* Multiple disabilities
* Unable to perform follow-up testing tasks (repeating words/sentences, indicating they heard a sound stimulus, completing questionnaires)
* Non-English speakers
* Children under the age of 18

Primary outcomes:
measure: Speech perception scores
timeFrame: 1-year
measure: Duration of programming session
timeFrame: 1-year
Secondary outcomes:
measure: Quality of Life questionnaire
timeFrame: 1-year
measure: Soundfield detection thresholds
timeFrame: 1-year
measure: programming levels
timeFrame: 1-year
Other outcomes:
Locations:
city: Boston
country: United States
facility: Mass Eye and Ear
state: Massachusetts
Study officials:
affiliation: Massachusetts Eye and Ear
name: Julie Arenberg
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03403816: Objective Assessment of Physical Activity in Before-school Physical Activity Programs
Official title: Objective Assessment of Physical Activity in Before-school Physical Activity Programs
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physical Activity
Sleep
Lead sponsor: Harvard School of Public Health (HSPH)
Sponsor class: OTHER
Collaborators: name: Reebok Foundation
name: Massachusetts General Hospital
First posted: 2018-01-19
Enrollment: 432
Sex: ALL
Minimum age (years): 5
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study will determine the effectiveness of a free before-school physical activity program, BOKS (Build Our Kids' Success), in increasing objectively measured physical activity levels among children in elementary and middle school in 7 schools in Massachusetts.

Detailed description: This study will determine the effectiveness of a free before-school physical activity program, BOKS (Build Our Kids' Success), in increasing objectively measured physical activity levels among children in elementary and middle school in 7 schools in Massachusetts. The study focuses on capturing valid and objective assessments of student-level physical activity during BOKS program time and assessing the impact of the BOKS program on overall daily physical activity levels using minute-by-minute physical activity level data among elementary aged students. Data is also collected to understand how increasing physical activity may impact students' sleep.

Eligibility criteria: Inclusion Criteria:

* Attending public elementary and middle school in two selected Massachusetts communities with BOKS programming

Exclusion Criteria:

* None

Primary outcomes:
measure: Total steps per day
timeFrame: Participants wore a Fitbit activity monitor for up to 5 school days beginning with the before school period simultaneously for 24 hours/day
Secondary outcomes:
measure: Active minutes
timeFrame: Participants wore a Fitbit activity monitor for up to 5 school days beginning with the before school period simultaneously for 24 hours/day
measure: Sleep duration
timeFrame: Participants wore Fitbit activity monitors for 24 hours for up to 5 school days
Other outcomes:
Locations:
Study officials:
References:
citation: Cradock AL, Barrett JL, Taveras EM, Peabody S, Flax CN, Giles CM, Gortmaker SL. Effects of a before-school program on student physical activity levels. Prev Med Rep. 2019 Jul 3;15:100940. doi: 10.1016/j.pmedr.2019.100940. eCollection 2019 Sep.