Clinical trial NCT06543251: Effect of High Intensity Interval Exercise Training in Patients With Allergic Rhinitis
Official title: The Effects of Training Between High-Intensity Interval and Moderate Continuous Exercise on Respiratory Function and Rhinitis Symptoms in Patients With Allergic Rhinitis.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Allergic Rhinitis
Keywords: Allergic rhinitis
Aerobic exercise
High intensity interval training
pulmonary function
cytokines
Lead sponsor: Chulalongkorn University
Sponsor class: OTHER
First posted: 2024-08-07
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study was to compare the effects of training between high-intensity interval training and moderate continuous exercise training on the pulmonary function, respiratory muscle strength, symptoms of patients with allergic rhinitis, cytokines, and oxidative stress in patients with allergic rhinitis.

Detailed description: 36 patients with allergic rhinitis were divided into 3 groups, 12 people per group: the control group (CON), the group with high-intensity interval training at a ratio of 1:2 (HIIT) and the group with moderate continuous training (MCT), 3 days per week, over a total period of 12 weeks. Before and after the experiment, lung function, respiratory muscle strength, allergic rhinitis symptoms, nasal blood flow rate, peak nasal inspiratory flow, nitric oxide levels, cytokines and quality of life were measured and used for statistical analysis.

Eligibility criteria: Inclusion Criteria:

* A patient with allergic rhinitis who underwent a skin prick test and received a positive result.
* Patients with persistent allergic rhinitis, male and female, with symptoms of nasal congestion, sneezing, nasal itching, and runny nose for more than 4 days per week, and an average score of 7 or more in the past week using the allergic rhinitis symptom assessment questionnaire.
* stopped taking all medicine before the study such as antihistamine for 3 days, oral steroid and nasal steroid for at least 2 weeks and leukotriene receptor antagonist for at least a week prior to the study
* had no exercise program, non-smoking and without any food supplementation for at least 6 months prior to the start of the study
* Must not have other respiratory diseases such as bronchitis, pertussis, pneumonia, pneumonitis, aspergilloma, tuberculosis, asthma, lung cancer, emphysema, etc.
* Have a body mass index (BMI) between 18.5 and 24.9 kg/m².
* Complete the Physical Activity Readiness Questionnaire (PAR-Q+) by answering "no" to all questions.

Exclusion Criteria:

* There is an unforeseen circumstance, such as an illness, that prevents participation in the research.
* Less than 80% of the research was completed.

Primary outcomes:
measure: Rhinitis symptom scores
timeFrame: Change from Baseline Rhinitis symptom scores at 12 weeks.
measure: Peak nasal inspiratory flow
timeFrame: Change from Baseline Peak nasal inspiratory flow scores at 12 weeks.
measure: Nasal blood flow
timeFrame: Change from Baseline Nasal blood flow scores at 12 weeks.
measure: Pulmonary Functions
timeFrame: Change from Baseline Pulmonary Functions at 12 weeks.
measure: Respiratory muscle strength
timeFrame: Change from Baseline Respiratory muscle strength at 12 weeks.
measure: Fraction exhaled nitric oxide
timeFrame: Change from Baseline Fraction exhaled nitric oxide at 12 weeks.
measure: Aerobic capacity
timeFrame: Change from Baseline Aerobic capacity at 12 weeks.
Secondary outcomes:
measure: Cytokine in nasal secretion
timeFrame: Change from Baseline Cytokine in nasal secretion at 12 weeks.
measure: Rhinoconjunctivitis quality of life questionnaire - 36; Rcq-36
timeFrame: Change from Baseline quality of life at 12 weeks.
Other outcomes:
Locations:
city: Pathum Wan
country: Thailand
facility: Faculty of Sports Science, Chulalongkorn University
state: Bangkok
Study officials:
affiliation: Chulalongkorn University
name: Wannaporn Tongtako, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: