louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05721625: Comparison of the Effects of Aerobic Exercise and Connective Tissue Massage in Postpartum Women
Official title: Comparison of the Effects of Aerobic Exercise and Connective Tissue Massage in Postpartum Women
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Postpartum Women
Keywords: sleep, depression, massage, exercise
Lead sponsor: Ankara Yildirim Beyazıt University
Sponsor class: OTHER
First posted: 2023-02-10
Enrollment: 40
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to compare the effects of aerobic exercise and connective tissue massage on sleep, mother-infant attachment and psychological state in postpartum women.

Detailed description: Postpartum period can affect the mental and physical health of women. Women may experience sleep problems and psychological problems due to hormonal changes and newborn care responsibilities. As a result, mother-infant attachment may also be affected. Physical activity and exercise should be encouraged in the postpartum period. It is known that aerobic exercises have positive effects on sleep and psychological problems. With the effects of connective tissue massage on the autonomic and circulatory system in the body, positive effects on sleep and psychological state can be achieved, but there are insufficient studies on this subject. In addition, no study has been found to the best of our knowledge comparing the effects of aerobic exercise and connective tissue massage in postpartum women.

Eligibility criteria: Inclusion Criteria:

* Postpartum 6th week-1 year
* Between the ages of 18-45
* Being literate

Exclusion Criteria:

* Those with orthopedic, neurological, rheumatological, mental or any systemic chronic diseases
* Those with cardiac problems that may interfere with exercise
* Those with suspected pregnancy
* Those with malignancy
* Those who have infection
* Those who do not regularly participate in the treatment program

Primary outcomes:
measure: Postpartum Sleep Quality Scale
timeFrame: change from baseline at 8 weeks
Secondary outcomes:
measure: Mother to Infant Bonding Scale
timeFrame: change from baseline at 8 weeks
measure: Edinburgh Postpartum Depression Scale
timeFrame: change from baseline at 8 weeks
Other outcomes:
Locations:
Study officials:
affiliation: Ankara Yildirim Beyazıt University
name: Seyda Toprak Celenay
role: STUDY_DIRECTOR
References:
Clinical trial NCT00734825: Emergency Department CT Scanning for Appendicitis
Official title: Emergency Department CT Scanning for Appendicitis: IV Contrast vs. IV and Oral Contrast
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Appendicitis
Keywords: Appendicitis
IV Contrast
Oral Contrast
CT scan
Lead sponsor: WellSpan Health
Sponsor class: OTHER
First posted: 2008-08-14
Enrollment: 244
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare IV contrast only vs. IV and oral contrast Computed Tomography (CT) for the diagnosis of acute appendicitis in adult patients in our emergency department. A secondary purpose will be to design a specific CT for appendicitis protocol at our institution at the conclusion of this study.


Eligibility criteria: Inclusion Criteria:

* 18 years and older who present to the York Hospital Emergency Department with signs and symptoms suggestive of acute appendicitis, but in whom the diagnosis remains unclear as determined by an attending emergency physician or consulting surgeon and in which a CT scan is needed to further assist in the diagnosis

Exclusion Criteria:

* pregnant patients
* patients with known IV dye or oral contrast allergy
* patients in whom acute appendicitis is not the primary diagnosis
* patients with renal insufficiency that may have significant adverse effect from IV dye

Primary outcomes:
measure: sensitivity of IV contrast alone for a computed tomography scan for the diagnosis of appendicitis in the adult Emergency Department patient.
timeFrame: immediate reading + blinded reading within 48 hours
Secondary outcomes:
measure: If IV contrast alone for CT scan is sensitive for the diagnosis of appendicitis in the adult Emergency department patient
timeFrame: immediate reading and blinded reading within 48 hours
Other outcomes:
Locations:
Study officials:
affiliation: WellSpan Health
name: Andrew Kepner, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kepner AM, Bacasnot JV, Stahlman BA. Intravenous contrast alone vs intravenous and oral contrast computed tomography for the diagnosis of appendicitis in adult ED patients. Am J Emerg Med. 2012 Nov;30(9):1765-73. doi: 10.1016/j.ajem.2012.02.011. Epub 2012 May 23.
Clinical trial NCT03991325: Sonographic Evaluation to Predict Difficult Airway Management
Official title: Sonographic Evaluation to Predict Difficult Airway Management
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Airway Management
Upper Airway Sonographic Evaluation
Lead sponsor: Mongi Slim Hospital
Sponsor class: OTHER
First posted: 2019-06-19
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Inclusion Criteria:

* patients scheduled for orthopedic or viseral surgery under general anesthesia and tracheal intubation.

Exclusion Criteria:

* patients with suspected tracheal stenosis
* Patients with a poor quality ultrasonographic exam

Brief summary: the aim of this study was to evaluate the accuracy of different ultrasonographic parameters and clinical tests to predict difficult airway assessment.

Ultrasonographic parameters were: hyo-mental distence, tongue width, skin to epiglottis distence and skin to hyoid bone distence. these parameters were recorded and their predictive acurracy was studied.

Detailed description: the aim of this study was to evaluate the accuracy of different ultrasonographic parameters and clinical tests to predict difficult airway assessment.

Ultrasonographic parameters were: hyo-mental distence, tongue width, skin to epiglottis distence and skin to hyoid bone distence. these parameters were recorded and their predictive acurracy was studied.

This study analyzed a sample size of 200 patients undergoing elective or urgent surgery under general anesthesia and recieving neuromuscular blocking agent before laryngoscopy.

the correlation between ultrasonographic parameters and difficult laryngoscopy was studied

Eligibility criteria: Inclusion Criteria:

* patients scheduled for orthopedic or viseral surgery under general anesthesia and tracheal intubation.

Exclusion Criteria:

* patients with suspected tracheal stenosis
* Patients with a poor quality ultrasonographic exam

Primary outcomes:
measure: prediction of difficult laryngoscopy with ultrasonographic criteria
timeFrame: 5 min after induction of general anesthesia determined by Cormack and Lehane grade
Secondary outcomes:
measure: prediction of difficult mask ventilation with ultrasonographic criteria
timeFrame: 3 min after induction of general anesthesia
Other outcomes:
Locations:
city: La Marsa
country: Tunisia
facility: Mongi Slim Hospital
state: Tunis
Study officials:
References:
Clinical trial NCT04234425: A Trauma-Informed Approach for Positive Youth Development for Montana Students
Official title: A Trauma-Informed Approach for Positive Youth Development for Montana
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Depression, Anxiety
Adolescent Behavior
Stress
Lead sponsor: Montana State University
Sponsor class: OTHER
First posted: 2020-01-21
Enrollment: 18
Sex: ALL
Minimum age (years): 11
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: Given the prevalence of suicide and mental health issues in rural Montana, this project is intended to help mitigate stressors that may contribute to poor behavioral and mental health in high school-aged children. The immediate goal is to determine viability of a partnership with a rural southwestern Montana school and test the feasibility of a piloted implementation of a trauma-informed yoga intervention to address behavioral health outcomes and positive youth development.


Eligibility criteria: Inclusion Criteria:

* Students enrolled in a specific weight training class at predetermined high school in rural Montana

Exclusion Criteria:

* Students not enrolled in a specific weight training class at predetermined high school in rural Montana

Primary outcomes:
measure: Salivary Cortisol Testing
timeFrame: Baseline and 4 weeks (Midpoint)
Secondary outcomes:
measure: Generalized Anxiety Disorder-7 Anxiety Scale
timeFrame: Baseline and 7 weeks after beginning of intervention
measure: Patient Health Questionnaire for Adolescents
timeFrame: Baseline and 7 weeks after beginning of intervention
measure: Strengths and Difficulties Questionnaire for Ages 11-17 (Overall Score)
timeFrame: Baseline and 7 weeks after beginning of intervention
Other outcomes:
Locations:
city: Livingston
country: United States
facility: Park High School
state: Montana
Study officials:
affiliation: Montana State University
name: Lauren E Davis, Doctoral
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05108025: DMT310-005 Topical in the Treatment of Acne Rosacea
Official title: A Study Of The Tolerability, Safety, And Efficacy Of DMT310 For The Treatment Of Acne Rosacea
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Acne Rosacea
Lead sponsor: Dermata Therapeutics
Sponsor class: INDUSTRY
First posted: 2021-11-04
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective is to evaluate the tolerability, safety, and efficacy of DMT310 topical powder mixed with diluent in male and female patients with moderate to severe facial acne rosacea.


Eligibility criteria: Inclusion Criteria:

Patient is male or non-pregnant female at least 18 years of age.

Clinical diagnosis of moderate to severe papulopustular acne rosacea as determined by:

Investigator's Global Assessment (IGA) at Randomization score of 3 or 4. Patient has at least 15 inflammatory lesions on the face

Patient is willing to apply the Investigational Product as directed

Patient is willing and able to comply with the protocol

Exclusion Criteria:

Patient is pregnant or planning to become pregnant Patient is taking a topical therapy on the face which may affect the patient's rosacea

Primary outcomes:
measure: Efficacy as measured by lesion counts
timeFrame: 12 Weeks
measure: Efficacy as measured by Investigator Global Assessment (IGA)
timeFrame: 12 Weeks
Secondary outcomes:
measure: Incidence of adverse events as a measure of safety and tolerability
timeFrame: 12 Weeks
Other outcomes:
Locations:
city: Austin
country: United States
facility: Dermata Investigational Site
state: Texas
Study officials:
References:
Clinical trial NCT00578825: A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome
Official title: A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Severe Acute Respiratory Syndrome
Keywords: Severe acute respiratory syndrome
Lead sponsor: Hospital Authority, Hong Kong
Sponsor class: OTHER_GOV
First posted: 2007-12-21
Enrollment: 340
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study aims to examine whether the combination of Lopinavir/Ritonavir plus Ribavirin for treatment of severe acute respiratory syndrome (SARS) is superior to placebo.


Eligibility criteria: Inclusion Criteria:

* Male or female over the age of 18 with a diagnosis of SARS and with valid consent will be recruited.

Exclusion Criteria:

* Subjects with medical conditions that makes the prescription of study medications unsafe are excluded.

Primary outcomes:
measure: Development of severe SARS
timeFrame: Any time during the acute illness
Secondary outcomes:
measure: Adverse events
timeFrame: Throughout the illness period
measure: SARS-CoV Viral load
timeFrame: Throughout the illness period
measure: Immunological profile
timeFrame: Throughout the illness period
Other outcomes:
Locations:
city: Hong Kong
country: China
facility: Department of Health
city: Hong Kong
country: China
facility: Kowloon Hospital
city: Hong Kong
country: China
facility: Prince of Wales Hospital
city: Hong Kong
country: China
facility: Princess Margaret Hospital
city: Hong Kong
country: China
facility: Queen Mary Hospital
city: Hong Kong
country: China
facility: The Chinese University of Hong Kong
city: Hong Kong
country: China
facility: The University of Hong Kong
city: Hong Kong
country: China
facility: Tuen Mun Hospital
city: Hong Kong
country: China
facility: United Christian Hospital
Study officials:
affiliation: Department of Medicine & Geriatrics, Princess Margaret Hospital
name: Wai Cho Yu, Dr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06618625: Tube Rotation for Tube Passage Into the Oral Cavity in Nasotracheal Intubation
Official title: The Effect of Tube Rotation on Passage of Tracheal Tube Through Nasopharynx Into the Oral Cavity in Nasotracheal Intubation
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Nasotracheal Intubation
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: SMG-SNU Boramae Medical Center
First posted: 2024-10-01
Enrollment: 80
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to investigate the effect of tube rotation on passage of the tracheal tube through the nasopharynx into the oral cavity in nasotracheal intubation.

Detailed description: This prospective randomized controlled study was approved by IRB of our institute.

Patients requiring nasotracheal intubation will be screened for eligibility of the study. Then, patients will be randomized to one of two groups; (group I: tube advancement in neutral / group II: tube advancement with the tube counter-clockwise rotated). After induction of anesthesia and muscle relaxation, the preformed nasal RAE (Ring-Adair-Elwyn) tube will be inserted via a nostril approximately 3-4 cm. Next, an anesthesiologist will advance the tube, with it neutral, continuously into the oral cavity of the patients in Group I, while the anesthesiologist will advance the tube, with it rotated counter-clockwise in 90 degree, into the oral cavity of the patients in Group II. After the tube will be placed in the oral cavity, the anesthesiologist will perform nasotracheal intubation with Magill forceps. After that, an investigator will check occurrence of epistaxis due to nasotracheal intubation and its severity with a fiberoptic bronchoscope. After obtainment of all data, investigators will analyze incidence of epistaxis and its severity between two groups.

Eligibility criteria: Inclusion Criteria:

* adult patients requiring nasotracheal intubation for elective surgery

Exclusion Criteria:

* refuse to participate in the study
* severe deformity in nose
* current severe epistaxis
* limitation of neck extension

Primary outcomes:
measure: tube blockade
timeFrame: during tube advancement from the nasal cavity to the oral cavity
Secondary outcomes:
measure: epistaxis
timeFrame: during nasotracheal intubation
Other outcomes:
Locations:
Study officials:
References:
citation: Kim H, Lee JM, Lee J, Hwang JY, Chang JE, No HJ, Won D, Row HS, Min SW. Effect of neck extension on the advancement of tracheal tubes from the nasal cavity to the oropharynx in nasotracheal intubation: a randomized controlled trial. BMC Anesthesiol. 2019 Aug 17;19(1):158. doi: 10.1186/s12871-019-0831-6.
Clinical trial NCT04177225: Effect of Diastolic Dysfunction on Dynamic Cardiac Monitors
Official title: Evaluation of Dynamic Monitors for the Prediction of Volume Responsiveness in Patients With and Without Diastolic Dysfunction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stroke Volume Variation
Diastolic Dysfunction
Lead sponsor: University of California, Davis
Sponsor class: OTHER
First posted: 2019-11-26
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients undergoing elective surgical procedures requiring arterial line pressure monitoring at the University of California Davis Medical Center Surgical Unit

Brief summary: This investigator initiated, prospective, observational, single-center study is designed to assess whether dynamic monitors of cardiac function such as stroke volume variation (SVV) that have been shown to predict volume responsiveness differ in clinical utility between patients with and without diastolic dysfunction.

Detailed description: This investigator initiated, prospective, observational, single-center study is designed to assess whether dynamic monitors of cardiac function, such as stroke volume variation (SVV), that have been shown to predict volume responsiveness differ in clinical utility between patients with and without diastolic dysfunction.

Specific Aims:

* Determine the threshold for the predictive response of SVV with respect to increasing cardiac output for patients with and without diastolic dysfunction.
* Compare the trans thoracic ultrasound assessment of left ventricular diastolic function before and after the induction of general anesthesia.

Eligibility criteria: Inclusion Criteria:

* Patients Undergoing Elective surgical procedures where invasive arterial line pressure monitoring is a planned part of the intraoperative management
* Age greater than or equal to 18
* Procedures requiring general anesthesia and mechanical ventilation

Exclusion Criteria:

* Adults unable to provide consent
* Atrial Fibrillation or other significant active arrhythmia
* Emergency Procedures
* Hemodynamic instability requiring vasopressor and/or inotropic infusions
* Presence of an intra-aortic balloon pump
* Open thoracic procedures
* Extremes of BMI less than 20 or greater than 40
* Pregnancy
* Prisoners
* Patient Refusal

Primary outcomes:
measure: Impact of diastolic function on the response threshold for stroke volume variation (SVV) as a predictor of the cardiac output response to fluid administration.
timeFrame: Through study completion, an average of 1 year
Secondary outcomes:
measure: Grade assessment of diastolic function
timeFrame: Through study completion, an average of 1 year
Other outcomes:
Locations:
city: Sacramento
country: United States
facility: UC Davis Health System
state: California
Study officials:
affiliation: University of California, Davis
name: Neal Fleming, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01978925: Pharmaceutical Care in Emergency Department
Official title: Effectiveness Pharmaceutical Care at Discharge in the Emergency Department: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Medication Adherence
Hypertension
Diabetes Mellitus
Keywords: Pharmaceutical care
Medication Adherence
Blood Pressure
Diabetes
Emergency
Lead sponsor: Hospital Moinhos de Vento
Sponsor class: OTHER
Collaborators: name: Ministry of Health, Brazil
First posted: 2013-11-08
Enrollment: 380
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the effectiveness of pharmaceutical care, compared to usual care, in patient discharge in an emergency department in patients with hypertension and/or diabetes mellitus type 2.

Detailed description: This is a randomized controlled, single-center study, with blinding of outcome assessors. A pilot study with ten patients was previously conducted in order to test study logistics and data collection instruments. Participants will be recruited from a public ED at Restinga district in Porto Alegre, southern Brazil.

Eligibility criteria: Inclusion Criteria:

* Blood pressure inadequate control (systolic blood pressure ≥ 160 or diastolic blood pressure ≥ 100 mmHg) or
* Diabetes mellitus inadequate Control( ≥ 200 mg/dL) or hypoglycemia moderate or severe
* Be referred to clinical care.

Exclusion Criteria:

* \< 18 years
* Not resident of Porto Alegre
* Diabetes mellitus type I
* Unable to answer the questionnaire or to sign the informed consent form
* Hospital admission
* Death

Primary outcomes:
measure: Medication Adherence
timeFrame: Two months
Secondary outcomes:
measure: Blood Pressure Control
timeFrame: Two months
measure: Glycated hemoglobin (HbA1C) for diabetic patients
timeFrame: two months
measure: Quality of Life
timeFrame: Two months
Other outcomes:
measure: Fasting plasma glucose for diabetic patients
timeFrame: Two months
Locations:
city: Porto Alegre
country: Brazil
facility: Emergency Department - Hospital Moinhos de Vento
state: Rio Grande do Sul
Study officials:
affiliation: Hospital Moinhos de Vento
name: Rodrigo A Ribeiro, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kuhmmer R, Lima KM, Ribeiro RA, Hammes LS, Bastos GA, Cotta de Souza MC, Polanczyk CA, Soares Rollin GA, Caon S, Guterres CM, Araujo Leite LE, Delabary TS, Falavigna M. Effectiveness of pharmaceutical care at discharge in the emergency department: study protocol of a randomized controlled trial. Trials. 2015 Feb 25;16:60. doi: 10.1186/s13063-015-0579-3.
Clinical trial NCT00477425: A Study to Evaluate Corrected QT Interval From Clinical Studies Conducted With Bevacizumab
Official title: Evaluation of Corrected QT Interval From Clinical Studies Conducted With Bevacizumab
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Carcinoma
Keywords: Avastin
Lead sponsor: Genentech, Inc.
Sponsor class: INDUSTRY
First posted: 2007-05-23
Enrollment: 0
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE

Brief summary: This is a supplemental study designed to evaluate the effect of bevacizumab on QTc interval in cancer patients. Patients who have consented to participate in selected randomized controlled bevacizumab clinical trials will be invited to participate in this study.


Eligibility criteria: Inclusion Criteria:

* Signed Informed Consent Form
* Enrollment in one of a list of certain randomized, controlled bevacizumab trials

Exclusion Criteria:

* Implantable pacemaker or automatic implantable cardioverter defibrillator (AICD)
* Congenital long QT syndrome
* Family history of long QT syndrome
* Clinically significant bradycardia (defined as \< 50 beats/minute)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Genentech, Inc.
name: Jane Huang, M.D.
role: STUDY_DIRECTOR
References: