Clinical trial NCT03275363: The University of Hong Kong Neurocognitive Disorder Cohort
Official title: The University of Hong Kong Neurocognitive Disorder Cohort
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Neurocognitive Disorder
Mild Cognitive Impairment
Alzheimer Dementia
Vascular Dementia
Age-related Cognitive Decline
Keywords: Subjective cognitive decline
Mild Cognitive Impairment
Dementia
Cerebral aging
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
Collaborators: name: Dementias Platform UK
First posted: 2017-09-07
Enrollment: 500
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Older adults with or without neurocognitive disoder. HKU NCD Cohort focuses primarily on people with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).

Brief summary: The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment.

Detailed description: The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment, and in particular the biomarkers that predict cognitive and functional decline.

Comprehensive profiling of each subject is performed through a multi-domain assessment protocol including detailed demographics, lifestyle factors, neuropsychological battery, mood, MRI, genetics, blood biomarkers, and other patient-centred parameters including level of disability, quality of life and societal engagement. Ongoing annual follow up captures the essential clinical events and changes in neurocognitive function (conversion to MCI or dementia), mood, level of disability and quality of life; as well as repeat blood tests.

The HKU NCD Cohort is the first-ever Asian dementia cohort to be formally included into the Dementia Platforms UK, achieving an international collaborative status with other UK-based cohorts. The study neuropsychological battery is aligned with the NACC UDS3 battery.

Eligibility criteria: Inclusion Criteria:

* Older adults with or without neurocognitive disoder. HKU NCD Cohort focuses primarily on people with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).

Exclusion Criteria:

* Severe Parkinson's disease, major depressive disorder or severe psychiatric conditions, significant communication difficulties (e.g. aphasia, deafness), terminal cancer or likely end-of-life in the next 12 months.

Primary outcomes:
measure: Cognitive decline
timeFrame: 1 year
Secondary outcomes:
measure: Functional decline
timeFrame: 1 year
measure: Neuropsychiatric decline
timeFrame: 1 year
measure: Quality of life decline
timeFrame: 1 year
measure: Change in cognitive impairment status
timeFrame: 1 year
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Department of Medicine, Queen Mary Hospital, The University of Hong Kong
Study officials:
affiliation: The University of Hong Kong
name: Joseph SK Kwan, MD
role: PRINCIPAL_INVESTIGATOR
References: