Clinical trial NCT01665235: Blood Pressure Variability and the Prognosis of Ischemic Stroke With Intracranial Artery Stenosis
Official title: The Correlation Study Between Blood Pressure Variability and the Prognosis of Ischemic Stroke With Intracranial Artery Stenosis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Blood Pressure Variability
Intracranial Artery Stenosis
Lead sponsor: RenJi Hospital
Sponsor class: OTHER
First posted: 2012-08-15
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Correlation study about Blood Pressure Variability and the prognosis of ischemic stroke with intracranial artery stenosis

Detailed description: Extracranial atherosclerotic stenosis is the main reason for the European and American white ischemic stroke and transient ischemic attack,while Atherosclerotic intracranial arterial stenosis is an important reason for Asian patients with stroke ,accounting for the 33% to 51% of a etiology ratio.The latest research suggests that varying degrees of blood pressure variability can affect the risk of stroke.This study observe the relationship between blood pressure variability and prognosis of ischemic stroke patients with intracranial arterial stenosis,with cranial magnetic resonance imaging (MRI + DWI),magnetic resonance angiography and Trans-cranial Doppler(TCD) .

Eligibility criteria: Inclusion Criteria:

* age : ≥ 18 years of age , ≤ 75 years old
* with intracranial artery stenosis in ischemic stroke
* the diagnosis of ischemic cerebrovascular disease are in line with the diagnostic criteria developed by the Chinese Medical Association Fourth National Cerebrovascular Disease Conference
* the patient admitted to hospital receive at least one examination like cranial MRI + DWI, MRA and TCD examination, clearly associated with intracranial arterial stenosis
* MRS score ≤ 3 points

Exclusion Criteria:

* vascular , cardiac , and unknown causes or other reasons lead to ischemic stroke
* associated with significant emotional disorders, cognitive impairment or other mental disorders can not be partners
* severe occlusion of Unilateral intracranial arteries ( over 90 % ) or bilateral stenosis more than 70%
* With extracranial artery stenosis, especially carotid and vertebral artery stenosis .
* patients with extracranial artery stenosis or patients previously done neck or intracranial artery balloon dilation , stent forming surgery or carotid endarterectomy
* Incomplete clinical data collection in patients

Primary outcomes:
measure: the incidence of stroke in a follow-up period
timeFrame: one year
Secondary outcomes:
measure: blood pressure during the compliance status in a follow-up
timeFrame: one year
measure: patients with blood pressure variability in a follow-up
timeFrame: one year
measure: Changes in intracranial arterial stenosis and stiffness before and after the follow-up
timeFrame: one year
measure: Other vascular events ( acute ischemic heart disease or vascular death )
timeFrame: one year
Other outcomes:
Locations:
city: Shanghai
country: China
facility: RenJi Hospital
state: Shanghai
Study officials:
affiliation: RenJi Hospital
name: Guowen Shi, MD
role: PRINCIPAL_INVESTIGATOR
References: