louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00430144: Belotecan (CKD-602) in Recurrent or Progressive Carcinoma of Uterine Cervix
Official title: A Phase II Study of Belotecan (CKD-602) in Recurrent or Progressive Carcinoma of Uterine Cervix
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Cervical Cancer
Lead sponsor: National Cancer Center, Korea
Sponsor class: OTHER_GOV
First posted: 2007-02-01
Enrollment: 16
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: -list item one, The purpose of this study is to evaluate the overall response rate of belotecan (CKD-602) in recurrent or progressive carcinoma of uterine cervix

Detailed description: * list item one, to evaluate toxicities of Belotecan
* list item two, to evaluate duration of primary response for responding patients
* list item three, to evaluate time to disease progression
* list item four, to evaluate progression free survival and overall survival.

Eligibility criteria: Inclusion Criteria:

* Histologically confirmed, patients with recurrent uterine cervical carcinoma who were unsuitable candidates for curative treatment with surgery and/or radiotherapy.
* One of the following histologic types
* Squamous cell carcinoma
* Adenocarcinoma
* Adenosquamous carcinoma
* Clinically measurable disease
* Performance status of 0, 1, 2 on the ECOG criteria

Exclusion Criteria:

* Histology of neuroendocrine tumors
* Patient previously treated with topoisomerase-I inhibitor

Primary outcomes:
measure: overall response rate of belotecan (CKD-602)
timeFrame: 1 week before the start of Cycle 4, 3 weeks later Cycle 6 or at discontinuation of study treatment, and then at least every 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: National cancer center
Study officials:
affiliation: National cancer cencer
name: Sokbom Kang
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hwang JH, Lim MC, Seo SS, Park SY, Kang S. Phase II study of belotecan (CKD 602) as a single agent in patients with recurrent or progressive carcinoma of uterine cervix. Jpn J Clin Oncol. 2011 May;41(5):624-9. doi: 10.1093/jjco/hyr017. Epub 2011 Feb 24.
Clinical trial NCT02868944: Interest of the Injection of Morphine, in Addition to a Local Anesthetic When Performing a Combined Spinal-epidural for Labor Analgesia
Official title: Interest of the Injection of Morphine, in Addition to a Local Anesthetic When Performing a Combined Spinal-epidural for Labor Analgesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Pregnant Women
Lead sponsor: CHU de Reims
Sponsor class: OTHER
First posted: 2016-08-16
Enrollment: 144
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The addition of morphine to a local anesthetic when performing an epidural analgesia during labor analgesia has improved the efficiency and the action duration of analgesia. One limitation of this technique is the time of installation of the analgesic effect (about 30 minutes) when using the only epidural. Therefore, the technique of sequential combined spinal epidural was introduced. This is to shorten the installation time by direct injection into the cerebrospinal fluid. This allows a good efficiency in less than 10 minutes. It has been shown that low doses of sufentanil (strong opioid) in spinal anesthesia could potentiate the effect of the local anesthetic.

Detailed description: Compare the results of obstetric analgesia by sequential combined spinal epidural with local anesthetic injection associated with morphine and a sequential obstetric analgesia by sequential combined spinal epidural with local anesthetic injection alone

Eligibility criteria: Inclusion Criteria:

* pregnant patients
* patients who experienced a physiological course of pregnancy
* patients for which it was estimated eutrophic fetus without pathology found during ultrasound
* patient consenting to participate to the study
* patient enrolled in the national healthcare insurance program
* patient older than 18 years and younger than 40 years

Exclusion Criteria:

* twin pregnancy
* contraindication to sequential combined spinal epidural

Primary outcomes:
measure: Visual analog pain scale
timeFrame: after 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Reims
country: France
facility: Chu de Reims
Study officials:
References:
Clinical trial NCT06885944: Probiotics for Preterm Infants
Official title: Probiotics for Preterm Infants After Full Enteral Feeding
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Preterm Infant Feeding Outcomes
Probiotic
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2025-03-20
Enrollment: 100
Sex: ALL
Minimum age (years): 7
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: preterm infants with a gestational age lower than 32 weeks and 1500 g of birthweight, reached to fully enteral feeds

Brief summary: Probiotics will be used for preterm infants under 32 weeks of gestation and under 1500 g birthweight. Our aim was to investigate the effects of probiotics for stable preterm infants after extubation and who reached full enteral feeding. There are some hesitations among care-givers to start probiotics early due to safety issues although there are many positive effects of these products reported int the literature.

Detailed description: Our study included premature babies with a birth weight of less than 1500 grams, born at less than 32 weeks of gestation, and without congenital anomalies.

Approval was obtained from the hospital's clinical research ethics committee before starting the study. The decision to start probiotics was made when these premature babies were fully enteral fed. The study design was created as a cohort and case-control study (No randomisation). When clinicians decided to start probiotic support for premature babies with good general health and no additional problems, probiotics were added to the baby's order.

Eligibility criteria: Inclusion Criteria: \<32 weeks, \<1500 g birthweight -

Exclusion Criteria: Congential anomalies, still parenteral feeding, BW\<800 gr and \<23 weeks of GA

-

Primary outcomes:
measure: Antropometric measures
timeFrame: 2 months
Secondary outcomes:
measure: Metabolic profile
timeFrame: 2 months
Other outcomes:
Locations:
Study officials:
affiliation: Ankara City Hospital Bilkent
name: FUAT EMRE CANPOLAT, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04146844: Prevalence of Two Major Geriatric Syndromes: Sarcopenia and Frailty
Official title: Prevalence of Two Major Geriatric Syndromes in Community- Dwelling Older Adults: Sarcopenia and Frailty
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sarcopenia
Frailty
Frailty Syndrome
Lead sponsor: Goztepe Training and Research Hospital
Sponsor class: OTHER
Collaborators: name: Istanbul Medeniyet University
name: Umraniye Education and Research Hospital
First posted: 2019-10-31
Enrollment: 500
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Community-dwelling older adults

Brief summary: Sarcopenia and frailty are two major syndromes in older adults. They are shown to be associated with low levels of functioning and higher rates of morbidity and mortality. In this study, we aim to report the prevalence of sarcopenia and frailty by using simple assessment methods such as SARC-F and FRAIL, respectively.


Eligibility criteria: Inclusion Criteria:

* Being at the age of 65 or older

Exclusion Criteria:

* \<24 points on Mini-Mental State Examination
* 12 points or higher on Geriatric Depression Scale

Primary outcomes:
measure: SARC-F
timeFrame: 5 minutes
measure: FRAIL
timeFrame: 5 minutes
Secondary outcomes:
measure: Study of Osteoporotic Fracture (SOF) Criteria for Frailty
timeFrame: 5 minutes
measure: Charlson Comorbidity Index
timeFrame: 5-10 minutes
measure: Rapid Assessment of Physical Activity (RAPA)
timeFrame: 10 minutes
measure: Mini-Nutritional Assessment (MNA)
timeFrame: 10 minutes
measure: Katz Index of Independence in Activities of Daily Living
timeFrame: 10 minutes
measure: Lawton -Brody Instrumental Activities of Daily Living Scale
timeFrame: 10 minutes
measure: Mini-Mental State Examination
timeFrame: 15 minutes
measure: Blood Sample Analysis
timeFrame: 5 minutes
measure: Geriatric Depression Scale- Short Form
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Umraniye Education and Research Hospital
Study officials:
References:
Clinical trial NCT04935944: Effect of FOV and mA on Metal Artifacts on CBCT
Official title: Effect of Variations of Field of View (FOV) and Milliampere (mA) on Metal Artifacts Produced by Dental Implants in Cone Beam Computed Tomography Image Quality. (In-vitro Study)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Metal Artifacts
Implant
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2021-06-23
Enrollment: 4
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Using different dry human mandibles with dummy implants.

Brief summary: The aim of this study is to evaluate the effect of exposure parameters as milliampere (mA) and field of view (FOV) in CBCT on metal artifact of dental implant.

Detailed description: Cone Beam Computed Tomography (CBCT) is considered an important valuable imaging technique in the diagnosis and treatment planning in oral and maxillofacial surgery as well as implant dentistry by means of three dimensional images which provide extra information about the buccolingual dimension of the alveolar bone with more details for bone anatomy and inclination.

To make an accurate diagnosis and treatment planning, we have to obtain images with more details and good resolution and quality which could be achieved by CBCT. However, there are some issues in scanned areas that can affect their quality such as presence of metals (metallic restorations, orthodontic appliances, dental implants, crowns) which result in artifacts which can be considered as an important cause of poor image quality which will lead to poor diagnosis.

There are many types of artifacts which can be observed on CBCT images. Beam hardening artifact is considered a common one which occurs when an x-ray beam comprised of polychromatic energies passes through an object, resulting in selective attenuation of lower energy photons. The effect is conceptually similar to a high-pass filter, in that only higher energy photons are left to contribute to the beam and thus the mean beam energy is increased ("hardened").

Eligibility criteria: Inclusion Criteria:

* Bio models of jaw with dummy implant.

Exclusion Criteria:

-

Primary outcomes:
measure: Dental implant linear measurement
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Roshan Adel
state: Giza
Study officials:
affiliation: Cairo University
name: Noha Issa, Associate Prof
role: STUDY_DIRECTOR
References:
Clinical trial NCT03746444: Postoperative Complications Following Total Knee Arthroplasty
Official title: Comparison of Effects of Combined Spinoepidural and General Anesthesia Effects on Incidence of Postoperative Complications Following Total Knee Arthroplasty
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Arthroplasty, Replacement, Knee
Keywords: total knee arthroplasty
general anesthesia
neuraxial anesthesia
complications
Lead sponsor: Ufuk University
Sponsor class: OTHER
First posted: 2018-11-19
Enrollment: 130
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this study is to investigate the effect of combined spinoepidural and general anesthesia on the incidence of postoperative complications following total knee arthroplasty

Detailed description: Total knee arthroplasty is known to cause complications (pulmonary thromboembolism, acute kidney injury, arryhthmias and infection). The investigators aimed to study the effects of two different anesthesia techniques, i.e. combined spinoepidural anesthesia and general anesthesia on the incidence of postoperative complications such as arrhythmia, pulmonary thrombeoembolism, infection, acute kidney injury and mortality.

Eligibility criteria: Inclusion Criteria:

* Patients scheduled to undergo elective unilateral total knee arthroplasty

Exclusion Criteria:

* Patient refusal
* Scheduled for bilateral or unilateral unicondylar knee arthroplasty
* Known history of allergy to drugs used in the study
* Severe systemic disease
* Morbid obesity (BMI\>30)
* History of renal dysfunction

Primary outcomes:
measure: Acute Kidney Injury
timeFrame: Postoperative first day
measure: Acute Kidney Injury
timeFrame: Postoperative sixth week
measure: Pulmonary Thromboembolism
timeFrame: Postoperative first day
measure: Pulmonary Thromboembolism
timeFrame: Postoperative sixth week
measure: Infection
timeFrame: Postoperative first day
measure: Infection
timeFrame: Postoperative sixth week
measure: Arryhthmia
timeFrame: Postoperative first day
measure: Arryhthmia
timeFrame: Postoperative sixth week
measure: Death
timeFrame: Postoperative first day
measure: Death
timeFrame: Postoperative sixth week
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ufuk University Dr. Rıdvan Ege Hospital
Study officials:
References:
citation: Memtsoudis SG, Sun X, Chiu YL, Stundner O, Liu SS, Banerjee S, Mazumdar M, Sharrock NE. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients. Anesthesiology. 2013 May;118(5):1046-58. doi: 10.1097/ALN.0b013e318286061d.
citation: Stundner O, Chiu YL, Sun X, Mazumdar M, Fleischut P, Poultsides L, Gerner P, Fritsch G, Memtsoudis SG. Comparative perioperative outcomes associated with neuraxial versus general anesthesia for simultaneous bilateral total knee arthroplasty. Reg Anesth Pain Med. 2012 Nov-Dec;37(6):638-44. doi: 10.1097/AAP.0b013e31826e1494.
Clinical trial NCT01792544: Clinical Reminders in Test Reports to Improve Guideline Compliance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Echocardiography
Lead sponsor: VA Palo Alto Health Care System
Sponsor class: FED
First posted: 2013-02-15
Enrollment: 1706
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study examines the impact of adding a statement to the echocardiography report that advises anyone reading the report regarding if and when a follow-up study is recommended.


Eligibility criteria: Inclusion Criteria:

All patients undergoing echocardiography where the physician creating the report feels a comment is appropriate regarding when follow-up should or should not occur.

Exclusion Criteria:

None.

Primary outcomes:
measure: Inappropriate follow-up
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: VA Palo Alto HCS
state: California
Study officials:
References:
Clinical trial NCT01340144: Evaluation of Patellar Crepitus Following Total Knee Arthroplasty
Official title: Evaluation of Patellar Crepitus Following PFC Sigma vs. PFC Sigma HP Total Knee Arthroplasty: Does Femoral Component Design Make a Difference?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Total Knee Replacement
Keywords: total knee replacement
patellar crepitus
Replacement of knee joint
Lead sponsor: Colorado Joint Replacement
Sponsor class: OTHER
Collaborators: name: DePuy Orthopaedics
First posted: 2011-04-22
Enrollment: 1250
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Colorado Joint replacement clinic

Brief summary: Analyze clinical data for a group of subjects implanted with a new surgical device designed to reduce the incidence of patellar crepitus following PCL-substituting TKA and compare that to a control group of subjects implanted with a TKA design known to have an incidence of patellar crepitus of approximately 5%.

Detailed description: Patellar crepitus and clunk following posterior cruciate substituting total knee arthroplasty is a persistent problem with a reported incidence as high as 14%. The development of this complication necessitates additional surgery in some patients. Numerous etiologies have been reported including design of the femoral component. Due to a higher than desired incidence of patellar crepitus with the PFC Sigma PS TKA, design modifications of the trochlear groove of the femoral component were introduced with the release of the PFC Sigma HP PS femoral component. The purpose of the proposed study is to evaluate the incidence of patellar crepitus after posterior cruciate substituting TKA utilizing the PFC Sigma vs. the PFC Sigma HP PS femoral components.

Eligibility criteria: Inclusion Criteria:

* subjects that received primary total knee replacement

Exclusion Criteria:

* Did not return for follow - up appointments Required any post operative manipulation

Primary outcomes:
measure: Evaluate for the Incidence of Patellar Crepitus Requiring Non-operative vs. Operative Treatment of Both the Study and Control Groups at a Minimum of 12 Months Following the TKA (Total Knee Arthroplasty) Procedure in Each Subject.
timeFrame: Two years after TKA (Total Knee Arthroplasty) procedure
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Porter Adventist Hospital
name: Raymond Kim, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00974844: Posterior Assisted Levitation of Dropped Nucleus
Official title: Posterior Assisted Levitation by Pars-Plana Levitator
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cataract
Keywords: posterior assisted levitation
Pars Plana
Dropped nucleus
cataract
complication of
surgery
Lead sponsor: Dow University of Health Sciences
Sponsor class: OTHER
First posted: 2009-09-10
Enrollment: 14
Sex: ALL
Minimum age (years): 30
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who had dropped nucleus during phacoemulsification

Brief summary: Dropping of nucleus is a common complication during cataract extraction by phacoemulsification. The investigators describe a new technique to retrieve the dropped nucleus by using an instrument called Pars Plana Levitator (ASICO-LLC, USA).

Detailed description: Upon recognition of posterior capsular rupture and dropping of nucleus phaco prob will be withdrawn, status of the nucleus will be visualized by posterior segment non contact lens and if the nucleus found floating, pars plana levitator will be introduced through temporal pars plana, its prongs will be opened and nucleus will be grasped between prongs. Nucleus will be lifted up till the anterior chamber where phacoemulsification will be performed in a usual manner and a posterior chamber intraocular lens will be implanted if possible in the remaining bag.

Eligibility criteria: Inclusion Criteria:

* Patients during cataract surgery whose nucleus will be dropped during phacoemulsification

Exclusion Criteria:

* Completely dropped nucleus touching the posterior pole

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Karachi
country: Pakistan
facility: Eye Unit III, Lyari General Hospital , Dow university of Health Sciences
state: Sindh
Study officials:
affiliation: Dow University of Health Sciences
name: Shahid Wahab, FCPS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01325844: The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery
Official title: The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prostate Cancer
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2011-03-30
Enrollment: 45
Sex: MALE
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study was designed to investigate the effects of epidural anesthesia combined with general anesthesia during laparoscopic surgery. The investigators hypothesized that epidural anesthesia will effectively block the activation of the sympathetic nervous system during surgery, thus activating nitric oxide and reducing splanchnic ischemia and decrease in postoperative renal function.


Eligibility criteria: Inclusion Criteria:

* ASA class 1 or 2 adult patients scheduled for endoscopic prostatectomy

Exclusion Criteria:

* Patient refusal
* Patients on diuretics
* Patients with renal failure (eGFR \< 60 ml/min/1.73 m2)

Primary outcomes:
measure: blood pressure with heart rate variability
timeFrame: 10 minutes after anesthesia induction
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
Study officials:
References: