louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04594174: Prediction Model of the Blood Pressure Response to the Administration of Fluids in Abdominal Surgery Using the Pram Method.
Official title: Prediction Model of the Blood Pressure Response to the Administration of Fluids in Abdominal Surgery Using the Pram Method.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Open Abdominal Surgery
Lead sponsor: Hospital Universitario La Fe
Sponsor class: OTHER
First posted: 2020-10-20
Enrollment: 320
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients scheduled for open abdominal surgery, older than 18 years. All sex participates and not gender based.

Brief summary: Fluid therapy is considered a first-line therapy in resuscitation protocols for hemodynamically unstable patients. The administration of fluids usually translates into an increase in Cardiac Output. However, not all patients increase mean blood pressure after fluid administration.

To determine if fluids the administration improves blood pressure, it is necessary to evaluate the dependence of preload, vasomotor tone, and left ventricular stroke volume.

The aim of this study is to confirm the usefulness of dynamic elastance, cardiovascular impedance, cardiac cycle efficiency, and other hemodynamic parameters calculated with the PRAM method as predictors of blood pressure response after fluid administration in open abdominal surgery. This will allow us to make and evaluate a predictive model for the blood pressure response after fluid administration in open abdominal surgery.


Eligibility criteria: Inclusion Criteria:

* Patients ≥ 18 years
* Patients scheduled for open abdominal surgery lasting ≥ 120 minutes under general anesthesia with mechanical ventilation and the use of VT of 8 ml / kg ideal weight and who require serious arterial monitoring.

Exclusion Criteria:

* Patients \<18 years.
* Patients\> 80 years.
* Pregnant women.
* Urgent surgery.
* ASA \>3
* Pathologies that may alter the quality of the arterial signal due to alterations of the dicrotic incisura.
* Poor quality of the arterial pressure wave due to artifacts of the transduction system (resonance and damping).
* Personal history of:
* Cardiac arrhythmia.
* Left ventricular ejection fraction \<30%
* Right ventricular dysfunction (peak systolic tricuspid annulus velocity \<0.16 m / sec)
* Intracardiac shunt
* Preoperative creatinine\> 1.4 mg / dl.
* Dialysis
* Previous treatment with beta-blockers

Primary outcomes:
measure: Dynamic elastacy ratio PPV/SVV
timeFrame: During surgery
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03976674: A Preoperative Cognitive Behavioural Therapy Program Based on Self-determination Theory for Bariatric Surgery Candidates
Official title: Evaluation of a Preoperative Cognitive Behavioural Therapy (CBT) Program Based on Self-determination Theory for Bariatric Surgery Candidates : an Open-label Controlled, Randomized, Superiority Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bariatric Surgery Candidate
Obesity
Keywords: Bariatric Surgery Candidate
Cognitive and Behavioural Emotional Therapies
Obesity
Lead sponsor: Lille Catholic University
Sponsor class: OTHER
First posted: 2019-06-06
Enrollment: 94
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The objective of this study is to evaluate the impact of a pre-surgical intervention program based on Cognitive and Behavioural Emotional Therapies, on the degree of dietary restriction of patients who are candidates for bariatric surgery in order to increase the long-term effectiveness of this kind of surgery


Eligibility criteria: Inclusion Criteria:

* Patient starting a preparation for bariatric surgery in the endocrinology department at St Philibert Hospital
* 18 ≤Age≤60 years
* Patient meeting the criteria of the High Authority of Health (HAS) for the agreement of a bariatric treatment
* Patient affiliated to the social security
* Patient giving informed consent

Exclusion Criteria:

* Low level of comprehension of French
* Pregnant women
* Patient under guardianship or curatorship.

Primary outcomes:
measure: Eating Disorder Examination-Questionnaire (EDE-Q) score
timeFrame: One year after therapy
Secondary outcomes:
Other outcomes:
Locations:
city: Lomme
country: France
facility: • Lille Catholic University Hospital Group, Saint Philibert Hospital
state: Haits De France
Study officials:
affiliation: GHICL
name: Cynthia CHEROUTRE
role: STUDY_CHAIR
References:
Clinical trial NCT06849674: Efficacy and Safety of Platelet-Rich Plasma as an Intraoperative Holding Solution in Hair Transplantation
Official title: Efficacy and Safety of Platelet-Rich Plasma as an Intraoperative Holding Solution in Hair Transplantation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hair Transplantation
Lead sponsor: Benha University
Sponsor class: OTHER
First posted: 2025-02-27
Enrollment: 60
Sex: MALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this study is to determine the efficacy of using platelet-rich plasma (PRP) versus 0.9% normal saline as a storage solution during follicular unit extraction (FUE) hair transplantation.


Eligibility criteria: Inclusion Criteria:

* Male patients who have androgenetic alopecia
* Patients who are interested in having their hair transplanted

Exclusion Criteria:

* Individuals with comorbidities
* History of keloids or hypertrophic scarring
* Low donor area density
* Other causes of alopecia
* Scalp infections
* Patients with a bleeding tendency
* Patients on anticoagulant therapy
* Patients who are HIV-positive or Hepatitis B- or C-positive

Primary outcomes:
measure: Change in Hair density
timeFrame: 12 weeks after hair transplantation
measure: Percentage of Hair Growth
timeFrame: 12 weeks after hair transplantation
Secondary outcomes:
measure: Patient satisfaction score
timeFrame: 12weeks after hair translantation
measure: Incidence of Postoperative complications
timeFrame: within 1 month after hair transplantation
Other outcomes:
Locations:
city: Benha
country: Egypt
facility: Dermatology, Venereology and Andrology Faculty of Medicine- Benha University
state: Qalyubia
Study officials:
affiliation: Dermatology, Venereology and Andrology Faculty of Medicine- Benha University
name: Amany I Mustafa, MD
role: STUDY_DIRECTOR
affiliation: Dermatology, Venereology and Andrology Faculty of Medicine- Benha University
name: Ahmed I Abdulkhaleq, MBBCh
role: STUDY_DIRECTOR
References:
Clinical trial NCT02450474: Mobilising Lower Limb Fluid for Hemodynamic Stability in Haemodialysis
Official title: Pilot Evaluation of Intermittent Pneumatic Compression and Neuromuscular Electrical Stimulation for Enhancing Vascular Refilling in Haemodialysis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Kidney Failure
Lead sponsor: The Leeds Teaching Hospitals NHS Trust
Sponsor class: OTHER
Collaborators: name: National Institute for Health Research, United Kingdom
First posted: 2015-05-21
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Cardiovascular disease is the leading cause of death of dialysis patients and poor fluid management is associated with the increased risk. One of the principal limitations in avoiding chronic fluid overload in this patient group is the refilling rate the rate at which fluid is transferred from tissues into the vascular system. If this rate cannot match the prescribed rate of fluid removal during dialysis the patient will end up with chronic fluid overload.

Two proposed methods of increasing the rate of refilling are intermittent pneumatic compression (IPC) devices, which increase the pressure of the fluid in tissue, and neuromuscular electrical stimulation (NMES) which activates the muscle pump and lymphatic drainage.

This investigation will trial the use of these two methods in patients suspected of having inadequate refilling rates. Outcome measures will be based on fluid status, presence of oedema and quality of life.


Eligibility criteria: Inclusion Criteria:

* Presence of lower limb oedema as defined by pitting
* Average post dialysis fluid overload in relation to target weight greater than 0.5 litres
* Greater than one dialysis session that included an intradialytic hypotensive episode in the previous month, defined by saline influsion or nursing intervention

Exclusion Criteria:

* Less than 18 years of age
* Less than 3 months dialysis vintage
* Presence of metal implants, amputations or the inability to be weighed

Primary outcomes:
measure: Fluid Status (Body composition monitor measurement of fluid status)
timeFrame: Weekly
measure: Quality of Life (Validated Kidney Disease Quality of Life (KDQOL36) quality of life measurement questionnaire and patient symptom questionnaire)
timeFrame: Weekly
Secondary outcomes:
Other outcomes:
Locations:
city: Leeds
country: United Kingdom
facility: Leeds Teaching Hospitals NHS Trust
Study officials:
References:
Clinical trial NCT04299074: Smartphone Addiction and Physical Activity
Official title: The Effect of Smartphone Addiction on Physical Activity Level
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sports Physical Therapy
Keywords: Addiction
Healthy individuals
Physical activity
Smartphone
Sport science
Lead sponsor: Pamukkale University
Sponsor class: OTHER
First posted: 2020-03-06
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: This study aimed to determine the effect of smartphone addiction on physical activity level in healthy individuals. A total of 300 (134 female) healthy university students were included in this study. The mean age of the subjects was 21.36 ± 2.33 year.

Detailed description: This study aimed to determine the effect of smartphone addiction on physical activity level in healthy individuals. A total of 300 (134 female) healthy university students were included in this study. The mean age of the subjects was 21.36 ± 2.33 year. The universe of the study consisted of volunteer students (Coaching Education, Physical Education and Sports Teaching, Sports Management, Recreation Departments) at the Faculty of Sport Sciences. Participants' demographic information was obtained and their physical activity levels were questioned with International Physical Activity Questionnaires (IPAQ) and smartphone addictions with the Smartphone Addiction Scale- Short Verison (SAS-SV).

Eligibility criteria: Inclusion Criteria:

* to be 18-35 old years

Exclusion Criteria:

* not to be sports science students

Primary outcomes:
measure: Questionnaire
timeFrame: This questionnaire is used during baseline assessment
measure: Scale
timeFrame: This scale is used during baseline assessment
Secondary outcomes:
Other outcomes:
Locations:
city: Deni̇zli̇
country: Turkey
facility: Pamukkale University
state: Kinikli
Study officials:
affiliation: Pamukkale University
name: Meryem BUKE
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01320774: Efficacy, Tolerability and Handling of Daivobet® Gel in Patients With Psoriasis Vulgaris
Official title: Efficacy, Tolerability and Handling of Daivobet® Gel in Patients With Psoriasis Vulgaris
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Psoriasis Vulgaris
Lead sponsor: LEO Pharma
Sponsor class: INDUSTRY
Collaborators: name: LEO Pharma GmbH, Neu-Isenburg, Germany
First posted: 2011-03-22
Enrollment: 588
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients visiting their attending dermatologist in the primary care clinic

Brief summary: The purpose of this observational study is to evaluate the efficacy, tolerability, quality of life and handling of Daivobet® Gel by both physician and patient in daily practise.


Eligibility criteria: Inclusion Criteria:

* Patients with light to moderate psoriasis vulgaris of trunk and extremities and treatment with Daivobet® Gel was planned anyway

Exclusion Criteria:

* Previous therapy with Daivobet® Gel
* Systemic therapy of psoriasis vulgaris
* Contraindications of Daivobet® Gel in the German package insert

Primary outcomes:
measure: Handling of Daivobet® Gel
timeFrame: After appr 4 weeks
Secondary outcomes:
measure: Quality of life
timeFrame: 4 weeks
measure: Physician's global Assessment of psoriasis vulgaris
timeFrame: 4 weeks
measure: Side effects
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Erlangen
country: Germany
facility: University Clinic of Erlangen Nuernberg
Study officials:
affiliation: University clinic Erlangen-Nuernberg
name: Michael Sticherling, Prof dr med
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05632874: The Effect of Relaxing Breathing Exercise Applied to Patients Before Bone Marrow Biopsy on Vital Signs, Pain and Anxiety Levels
Official title: The Effect of Relaxing Breathing Exercise Applied to Patients Before Bone Marrow Biopsy on Vital Signs, Pain and Anxiety Levels
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Bone Marrow Cancer
Keywords: bone marrow biopsy
pain
breathing exercise
anxiety
Lead sponsor: Uskudar University
Sponsor class: OTHER
First posted: 2022-12-01
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: There is no study in the literature that determined the effect of relaxing breathing exercise applied to patients before the BMB procedure on vital signs, pain and anxiety levels.

The aim of this study is to determine the effect of relaxing breathing exercise applied to patients before bone marrow biopsy on vital signs, pain and anxiety levels.

hypotheses H1. Relaxing breathing exercise applied to the patients before the bone marrow biopsy procedure reduces the anxiety level of the patients compared to the control group.

H2. Relaxing breathing exercise applied to the patients before the bone marrow biopsy procedure reduces the pain level of the patients compared to the control group.

H3. Relaxing breathing exercise applied to the patients before the bone marrow biopsy procedure is effective on the respiratory rate of the patients compared to the control group.

H4. Relaxing breathing exercise applied to the patients before the bone marrow biopsy procedure is effective on the pulse rate of the patients compared to the control group.

H5. Relaxing breathing exercise applied to the patients before the bone marrow biopsy procedure is effective on the blood pressure of the patients compared to the control group.


Eligibility criteria: * Being between the ages of 18-65
* The fact that a bone marrow biopsy will be performed for the first time
* Absence of sedative, anxiolytic drug use
* Absence of a situation that would hinder communication.

Primary outcomes:
measure: Visual Analouge Scale
timeFrame: up to 1 mounth
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Uskudar Universitesi
Study officials:
References:
Clinical trial NCT05391074: Oral Postbiotics in Patients With Macular Atrophy
Official title: Pilot Study to Evaluate the Safety and Efficacy of Oral Therapy With Postbiotics in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration, Myopia, or Angioid Streaks
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Geographic Atrophy
Age-Related Macular Degeneration
Keywords: postbiotics
microbiota
microbiome
geographic atrophy
atrophic AMD
AMD
age-related macular degeneration
Lead sponsor: Institut de la Macula y la Retina
Sponsor class: OTHER
Collaborators: name: Igen BioLab SLU
First posted: 2022-05-25
Enrollment: 10
Sex: ALL
Minimum age (years): 55
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A pilot study to evaluate the safety and efficacy of oral therapy with Postbiotics in patients with geographic atrophy secondary to age-related macular degeneration, myopia, or angioid streaks.

Detailed description: A pilot study to evaluate the safety and efficacy of oral therapy with Postbiotics in patients with geographic atrophy (GA) secondary to age-related macular degeneration, myopia or angioid streaks.

The study's main objective is to evaluate if oral postbiotic therapy will induce epigenetic factors that would impact the progression of the GA, and it will compare the rate of growth of GA from the Baseline to 12 months, to the rate shown during the 12 months before Baseline.

Eligibility criteria: Inclusion Criteria:

* patients with GA secondary to AMD, myopia or angioid streaks
* with 12 months of previous follow-up,
* and a known progression of \>0,20mm/year as per SQRT

Exclusion Criteria:

- history of choroidal neovascularization in the study eye

Primary outcomes:
measure: rate of growth of geographic atrophy (GA) as per SQRT (square roor transformation) of area of GA measured in FAF, (fundus autofluorescence)
timeFrame: 12 months
measure: safety and tolerability
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Institut de la Màcula
Study officials:
affiliation: Institut de la Màcula
name: Jordi Monés, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02096874: Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema
Official title: The Effect of Bevacizumab on Peripheral Retinal Changes as Imaged by Wide -Field Fluorescein Angiography in Diabetic Macular Edema
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Non-proliferative Diabetic Retinopathy
Proliferative Diabetic Retinopathy
Diabetic Macular Edema
Keywords: Peripheral retinal ischemia
ultra wide field fluorescein angiography
Bevacizumab
Lead sponsor: King Khaled Eye Specialist Hospital
Sponsor class: OTHER_GOV
First posted: 2014-03-26
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Ultra-wide field fluorescein angiography can detect the response of anti VGEF therapy such as Avastin on retinal ischemia in the setting of diabetic macular edema.

Detailed description: The major causes of vision loss in diabetic retinopathy are diabetic macular edema (DME) characterized by thickening of the macula due to abnormal leakage of the retinal vasculature. Ischaemic changes and microvascular pathologies have long been hypothesized to play a role in the development of DME. In diabetic retinopathy, ischaemia stimulates the production of vascular endothelial growth factor (VEGF), which can lead to the breakdown of blood-retinal barriers, and may cause DME through an increase in retinal vessel permeability. DME is best evaluated by optical coherence tomography (OCT) while retinal ischemia is determined by Fluorescein angiography. With the avaiability of ultra wide field fluorescein angiography, the investigators can now accurately measure the degree of ischemia in peripheral retina. Thus, this study will provide us data on the degree of retinal ischemia in nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) cases as well as the measurable change that occurs in retinal ischemia after intra vitreal injection of bevacizumab.

Eligibility criteria: Inclusion Criteria:

1. Diabetic patients at age \>18year with DME
2. Scheduled for Avastin therapy
3. Adequate media to obtain OCT and UWFA

Exclusion Criteria:

1. Macular pathology of any etiology
2. Preexisting systemic disease causing retinal ischemia
3. Previous laser or anti-VEGF treatment in past 3 months
4. Previous retina surgery in past 2 months
5. Allergy to fluorescein dye
6. Psychiatric disorder, Alzheimer disease and Dementia or any other disorder precluding follow-up or continuation of the study.

Primary outcomes:
measure: Peripheral retinal ischemia
timeFrame: 24 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Riyadh
country: Saudi Arabia
facility: King Khaled Eye Specialist Hospital
Study officials:
affiliation: King Khaled Eye Specialist Hospital
name: Saba al Rashaed, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05599074: Stability of Anterior Open Bite Treatment Using Extrusion Arches
Official title: Treatment Results and Stability of Anterior Open Bite Cases Treated Using Extrusion Arches in Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anterior Open Bite Malocclusion
Keywords: extrusion arches
anterior open bite
stability
extrusion
intrusion
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2022-10-31
Enrollment: 23
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Before and after design
Primary purpose: TREATMENT

Brief summary: This study investigated treatment effects and stability of anterior open bite cases using extrusion arches


Eligibility criteria: Inclusion Criteria:

* adult patients above 18 years anterior open bite 2-6 mm full permanent dentition incisors requiring extrusion

Exclusion Criteria:

* increased incisal show at rest
* gum show at smiling cleft patients patient with tempro-mandibular joint problems FMA angle above 45

Primary outcomes:
measure: SNA angle
timeFrame: 18 months
measure: SNB angle
timeFrame: 18 months
measure: ANB angle
timeFrame: 18 months
measure: SN-MP angle
timeFrame: 18 months
measure: PP-MP angle
timeFrame: 18 months
measure: AFH
timeFrame: 18 months
measure: interincisal angle
timeFrame: 18 months
measure: L1 to MP in mm
timeFrame: 18 months
measure: L1 to MP angle
timeFrame: 18 months
measure: overbite
timeFrame: 18 months
measure: U1 to PP angular and linear measurements
timeFrame: 18 months
measure: u6 to pp angle
timeFrame: 18 months
measure: U6 to PP in mm
timeFrame: 18 months
measure: L6 to MP angle
timeFrame: 18 months
measure: L6 to MP in mm
timeFrame: 18 months
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Alexandria faculty of Dentistry
Study officials:
affiliation: Alexandria University
name: tasneem hammad, BDS
role: PRINCIPAL_INVESTIGATOR
affiliation: Alexandria University
name: hanan ismail, PHD
role: STUDY_DIRECTOR
References: