Clinical trial NCT05937412: A Comparative Study Between Honey and Alcohol as Topical Skin Disinfectant
Official title: A Comparative Study Between Honey and Alcohol as Topical Skin Disinfectant
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Disinfectant Causing Toxic Effect
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2023-07-10
Enrollment: 70
Sex: ALL
Minimum age (years): 2
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Skin antisepsis is essential in every healthcare environment. Alcohol/chlorhexidine use might disrupt skin microbiota and lead to antibiotic resistance.

This study investigates honey (being natural product with many beneficial therapeutic effects) as topical skin anti-septic agent and compares it with alcohol, in terms of effectiveness and safety.

Detailed description: Recent years' investigations of the co-evolution and functional integration of the human body and its commensal microbiota have disclosed that the microbiome has a major impact on physiological functions including protection against infections.

Invasive procedures such as injections, punctures or surgeries penetrate the skin's natural protective barrier, which may allow pathogenic microorganisms to enter deeper skin layers and cavities and trigger infections there.

Alcohols usually in the form of 70% isopropyl alcohol or 60 to 80% ethyl alcohol, are commonly used topical disinfectants.

Despite being efficiently broad-spectrum antiseptic, Alcohol shows some local hazards affecting skin integrity and microbiome.

Honey has been used in wound care since ancient. It has many beneficial therapeutic effects, including anti-microbia, antioxidant, immune-modulator, wound healing and synbiotic effects .

Antimicrobial agents are important in reducing the burden of infectious diseases.

Eligibility criteria: Inclusion Criteria:

* - Children aged from 2 to 12 years, of both sexes, and with apparently healthy skin.
* Children, who did not receive any form of antimicrobial agent for at least one-week prior study.

Exclusion Criteria:

* - Immuno-compromised due to diseases or drugs.
* - Children having any skin disease as eczema or others

Primary outcomes:
measure: Assess efficacy of honey as a disinfectant in comparison to the standard disinfectant which is alcohol
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University, Cairo
Study officials:
affiliation: Ain Shams University
name: mamdouh abdelmaksoud
role: STUDY_DIRECTOR
affiliation: Ain Shams University
name: yosra awad
role: STUDY_DIRECTOR
affiliation: Ain Shams University
name: maha ahmad
role: STUDY_DIRECTOR
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