Clinical trial NCT01048125: Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy
Official title: Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Cardiomyopathy
Keywords: Stress-induced cardiomyopathy
Takotsubo cardiomyopathy
Lead sponsor: University of Missouri-Columbia
Sponsor class: OTHER
First posted: 2010-01-13
Enrollment: 2
Sex: ALL
Minimum age (years): 21
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Stress (Takotsubo) cardiomyopathy (SC) is a peculiar form of acute, reversible myocardial dysfunction predominantly affecting the apical and mid left ventricular segments.

In this institution over the last two to three years the investigators have identified more than a dozen patients with stress cardiomyopathy. The investigators' overarching goal is to characterize these individuals with the hope of identifying risk factors and developing strategies to prevent the occurrence of SC in situations where the likelihood in susceptible individuals may be high.

Detailed description: Stress (Takotsubo) cardiomyopathy (SC) is a peculiar form of acute, reversible myocardial dysfunction predominantly affecting the apical and mid left ventricular segments. This was originally described in Japan but is increasingly recognized all over the world especially in older women. There is evidence to support that excess sympathetic activation and catecholamine surges are potential mechanisms that cause this temporary myocardial 'stunning'. The amount of catecholamines in circulation of patients with SC was 2 to 3-fold higher when compared to subjects with acute myocardial infarction related equivalent cardiac dysfunction \[Wittstein, et al. NEJM, 2005\].

In this institution over the last two to three years the investigators have identified more than a dozen patients with stress cardiomyopathy. This diagnosis has been confirmed by echocardiographic documentation of normalization of left ventricular function over a course of few days to weeks. The investigators' overarching goal is to further characterize these individuals with the hope of identifying risk factors and developing strategies to prevent the occurrence of SC in situations where the likelihood in susceptible individuals may be high.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of stress cardiomyopathy in the past

Exclusion Criteria:

* Coronary artery disease (CAD), primary coronary intervention (PCI) or coronary artery bypass graft (CABG)
* Cardiac dysfunction
* Heart failure
* Significant arrhythmias
* Severe chronic obstructive pulmonary disease (COPD)
* Diabetic neuropathy
* Pregnancy

Primary outcomes:
measure: Identifying Risk Factors and Developing Strategies to Prevent the Occurrence of Stress Cardiomyopathy in Situations Where the Likelihood in Susceptible Individuals May be High.
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Columbia
country: United States
facility: University of Missouri
state: Missouri
Study officials:
affiliation: University of Missouri-Columbia
name: Anand Chockalingam, MD
role: PRINCIPAL_INVESTIGATOR
References: