Clinical trial NCT02186769: An Randomized Open-Label PK Study of LY03004 Compared to Risperdal® Consta® in Stable Patients With Schizophrenia or Schizoaffective Disorder
Official title: A Randomized, Open-Label Pharmacokinetic Study of LY03004 Compared to Risperdal® Consta® Following a Single Intramuscular Injection at 25 mg or 50 mg in Stable Patients With Schizophrenia and/or Schizoaffective Disorder
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Schizophrenia
Schizoaffective Disorder
Lead sponsor: Luye Pharma Group Ltd.
Sponsor class: INDUSTRY
First posted: 2014-07-10
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A review of the amount of drug in your blood over time.


Eligibility criteria: Inclusion Criteria:

1. Male or female patients aged 18 to 65 years old;
2. Patients must have a DSM-IV diagnosis of schizophrenia or schizoaffective disorder based on the Mini-International Neuropsychiatric Interview (MINI);
3. Patients must be clinically stable on antipsychotic medications other than risperidone or paliperidone or clozapine for at least 4 weeks prior to screening, based on clinical assessments and a Positive and Negative Syndrome Scale (PANSS) total score less than or equal 70 at screening visit;
4. Patients with a Body Mass Index in range of 18.0 to 35.0;
5. Patients with an Informed consent form signed by the patient or legally acceptable representative

Exclusion Criteria:

1. Patients with a mental disorders other than schizophrenia or schizoaffective disorder, according to the DSM-IV;
2. Patients who received oral risperidone or paliperidone or clozapine within 14 days prior to screening, or Risperdal® Consta® within 100 days or LY03004 within 80 days prior to screening or paliperidone palmitate within 10 months prior to screening;
3. Patients with neuroleptic malignant syndrome or physical fatigue associated with dehydration or malnutrition;
4. Patients who pose a significant risk of a suicide attempt based on history, investigator's judgment or have answered "yes" on the questions 4 or 5 for current or past 30 days on the Baseline/Screening Version of the Columbia Suicide Severity Rating Scale (C-SSRS).
5. Patients with a history of sensitivity to akathisia and other EPS, especially with previous use of risperidone or paliperidone.
6. Patients with uncontrolled diabetes mellitus as indicated by a HbA1c level greater than or equal 7%;
7. Patients with a history of or currently having epilepsy or convulsion disorders;
8. Patients who have had electroconvulsive therapy within the past 2 months prior to screening;
9. Patients who used medication known to be an inducer or inhibitor for CYP 2D6 less than 2 weeks prior to screening;
10. Patients with a history of allergic reaction to risperidone or to the excipients of LY03004;
11. Patients who have met DSM-IV-TR criteria for substance abuse or dependence with the exception of caffeine or nicotine in the past 6 months prior to screening
12. Patients with a history of clinically relevant cardiac arrhythmia's, cardiovascular disease, thyrotoxicosis, parkinsonism, or hemorrhagic diathesis;
13. Patients who are currently taking medications with primarily CNS activities such as antidepressants, mood stablizers or anticonvulsants;
14. Patients who have participated in a clinical trial of another investigational drug within 30 days prior to screening;
15. Female patients who are pregnant or are breastfeeding or are of childbearing potential without adequate contraception.
16. Patients who have any clinically relevant hepatic, renal and cardiac dysfunction, or other medical condition or laboratory abnormality, which in the judgment of the investigator would interfere with the subject's ability to participate in the study

Primary outcomes:
measure: Cmax for the Pharmacokinetics (PK) of Risperdal® Consta®
timeFrame: 57 days
Secondary outcomes:
Other outcomes:
Locations:
city: Orange County
country: United States
facility: Neuropsychiatric Research Center of Orange County
state: California
city: Austin
country: United States
facility: Community Clinical Research Inc
state: Texas
Study officials:
References: