Clinical trial NCT02819674: The Chinese Early-onset Hypertension Study (CHESS)
Official title: The Chinese Early-onset Hypertension Study (CHESS)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hypertension
Keywords: hypertension
early onset
target organ damage
Lead sponsor: China National Center for Cardiovascular Diseases
Sponsor class: OTHER_GOV
First posted: 2016-06-30
Enrollment: 5000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Between October 2012 and December 2020(anticipated) recruited from multiple centers in China, in accordance with the diagnosis of hypertension, and less than 40 years when diagnosed

Brief summary: Hypertension (HTN) is the most important cardiovascular risk factor which is responsible for 50% of cardiovascular morbidity and mortality, and also a substantial public health problem affecting approximately 1/4 of the adult population in industrialized societies and over 1 billion people worldwide. Chronically elevated blood pressure without well control puts people at increased risk of target organ damages, including stroke, myocardial infarction, congestive heart failure, end-stage renal disease, blindness, and death. Especially, these damages are dramatically more severe in the early-onset hypertensive population.

Detailed description: In this study, the hypertensive individuals are consecutively recruited from multiple centers, with an early onset age (less than 40 when diagnosed). A complete clinical history (information on history of hypertension, demographic characteristics, personal and family medical history) are collected by a trained staff using a standardized questionnaire on the first day of baseline observation, and physical examination are also collected in a standard procedure. Blood samples are collected after 12-hour overnight fast and biological variables are determined. Genomic DNA is isolated from leukocytes according to a standard procedure. The individuals will receive follow-up in an ordinal system. The investigators will focus on the clinical and genetic features, genotype-phenotype correlations and influencing factors of prognosis in Chinese early-onset hypertension patients.

Eligibility criteria: Inclusion Criteria:

* In accordance with the diagnosis of hypertension (BP≥140/90mmHg), and less than 40 years when diagnosed

Exclusion Criteria:

-

Primary outcomes:
measure: primary mortality of early-onset hypertension
timeFrame: through study completion, an average of 5 years
Secondary outcomes:
measure: secondary outcomes of heart
timeFrame: through study completion, an average of 5 years
measure: secondary outcomes of brain
timeFrame: through study completion, an average of 5 years
measure: secondary outcomes of kidney
timeFrame: through study completion, an average of 5 years
measure: secondary outcomes of eyes
timeFrame: through study completion, an average of 5 years
Other outcomes:
Locations:
city: Beijing
country: China
facility: Fuwai hospital
state: Beijing
Study officials:
affiliation: Chinese Academy of Medical Sciences, Fuwai Hospital
name: Lei Song, MD.& PhD.
role: PRINCIPAL_INVESTIGATOR
References: