louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03378063: Stem Cells for Bronchopulmonary Dysplasia
Official title: Stem Cells for Bronchopulmonary Dysplasia: a Cohort Study
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: EARLY_PHASE1
Conditions: Bronchopulmonary Dysplasia
Lead sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Sponsor class: OTHER
Collaborators: name: Children's Hospital of Chongqing Medical University
name: Chongqing Maternal and Child Health Hospital
First posted: 2017-12-19
Enrollment: 0
Sex: ALL
Minimum age (years): 1
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Very preterm infants are at high risk to develop to bronchopulmonary dysplasia (BPD) for the lack of effective measures to prevent or ameliorate this common and serious disorder. BPD remains a major cause of mortality and lifelong morbidity in preterm infants

Detailed description: Several studies have shown that transplantation of mesenchymal stem cells (MSCs) in immunocompetent animals attenuates lung injury, such as impaired alveolarization, inflammatory response, increased apoptosis, and fibrosis. Human umbilical cord blood (hUCB) is considered a better source of MSCs because of their ready availability and greater proliferative capacity and less antigenicity than other cell types.

transplantation of hUCB-derived MSCs should be effective in treating BPD. The safety and efficacy of MSC transplantation for prevention of BPD has not been tested previously, however.

Eligibility criteria: Inclusion Criteria:

* diagnosed with BPD

Exclusion Criteria:

* parents' rejection

Primary outcomes:
measure: death
timeFrame: within two years
Secondary outcomes:
measure: Bayley Scales of Infant Development
timeFrame: 30 months after birth
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University
state: Chongqing
Study officials:
References:
Clinical trial NCT06537063: Detection of G-quadruplex DNA Methylation in Cancer
Official title: Early Diagnosis Value of G-quadruplex DNA Methylation in Patients with Cancer
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Cancer
DNA G-quadruplex
Methylation
Cell-free DNA
Lead sponsor: Zhongnan Hospital
Sponsor class: OTHER
First posted: 2024-08-05
Enrollment: 0
Sex: ALL
Minimum age (years): 42
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Healthy volunteers, aged 42 years or older, who are asymptomatic as determined by medical examination and willing to participate voluntarily in the study with signed informed consent.

Brief summary: This study aims to evaluate the early diagnosis value of G-quadruplex DNA methylation in patients with cancer.

Detailed description: Global DNA hypomethylation is a hallmark of most cancers that occurs early during oncogenesis. We would like to investigate whether cancer-specific transcription factor binding to DNA G-quadruplex drives DNA hypomethylation in cancer. In this observational study, we would like to clarify whether DNA hypomethylation around G-quadruplex loci in cell-free DNA could be detected in early-stage cancer patients from healthy donors with high sensitivity and specificity.

Eligibility criteria: Inclusion Criteria:

* Healthy volunteers identified as asymptomatic during medical examination;
* Age≥42 years old;
* Voluntarily participate in this study and sign the informed consent.

Exclusion Criteria:

* History of malignancy or having achieved complete remission following tumor surgery;
* Certain autoimmune diseases (e.g., systemic lupus erythematosus, Sjögren's syndrome, antiphospholipid syndrome, rheumatoid arthritis, Crohn's disease, IgA nephropathy, myasthenia gravis, dermatomyositis, immune thrombocytopenic purpura, etc.);
* Pregnancy;
* Acute trauma (including surgical procedures), sudden onset organ failure (e.g., resulting from a car accident, fulminant hepatic failure, acute pancreatitis, severe pneumonia due to influenza virus), or diagnosis of sepsis;
* Previous receipt of allogeneic blood transfusion, transplant surgery, or allogeneic cell therapy;
* Volunteers who cannot provide informed consent.

Primary outcomes:
measure: G-quadruplex DNAm score
timeFrame: 2024.04.30-2024.09.30
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Hubei Locations
state: Hubei
Study officials:
References:
Clinical trial NCT02815163: The Effects of Using the Empowerment Model Intervention in Primary Total Hip Replacement Surgery Elders
Official title: The Effects of Using the Empowerment Model Intervention in Primary Total Hip
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Empowerment
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2016-06-28
Enrollment: 108
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Degenerative arthritis is a common and serious chronic illness that impacts the quality of life of older adults. Knowledge about the effects of empowerment education program in older adults with total hip replacement surgery are limited. As far as the investigators know, this is the first study done using empowerment education intervention to promote total hip replacement patients' self-care. This partnership is achieved through active participation to learn as well as sharing their knowledge and experiences with clinicians and patients. Furthermore, patients had developed some degree of self-efficacy and improve their depressive mood from the disease related knowledge acquired.

Detailed description: Aims. To exam the effectiveness of the empowerment education program on primary (self-care self-efficacy and competence) and secondary outcomes (Activities of Daily Life, mobility, depressive mood, and quality of life) for older adults with total hip replacement surgery.

Background. Degenerative arthritis is a common and serious chronic illness that impacts the quality of life of older adults. As joints degenerate continuously and the hip has been damaged by arthritis, Activities of Daily Life will be difficult to perform due to severe hip pain and joint stiffness. Therefore, hip replacement surgery should be considered, and effective nursing care should be provided to improve the recovery of older adults.

Design. A prospective randomized control trial. Methods. A trial was conducted from September of 2013 to May of 2014 in two hospitals in northern Taiwan. 108 participants were randomly assigned to either the empowerment education group or the comparison group. The outcomes were collected at the day of discharge (T2), one month after (T3), and 3 months (T4) after the discharge.

Eligibility criteria: Inclusion Criteria:

* had 1st THRS
* ability to speak and read Chinese
* willingness to participate in this study

Exclusion Criteria:

* cognitive impairment or been diagnosed with a psychiatric illness
* participation in another study

Primary outcomes:
measure: Total Hip Replacement Self-efficacy Scale
timeFrame: 5min
measure: Self-care competence Scale
timeFrame: 5min
Secondary outcomes:
measure: ADL
timeFrame: 3min
measure: Tinetti mobility
timeFrame: 3min
measure: GDS-15
timeFrame: 3min
measure: SF-36
timeFrame: 3min
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02439463: Traumatic Below-knee Amputees With Prosthetics: Health-related Quality of Life and Locomotor Capabilities
Official title: Traumatic Below-knee Amputees With Prosthetics: Health-related Quality of Life and Locomotor Capabilities
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Amputees
Lead sponsor: Helsinki University Central Hospital
Sponsor class: OTHER
First posted: 2015-05-08
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Below-knee amputees who use limb prosthesis

Brief summary: The present study assesses the health-related quality of life and the locomotor capabilities major traumatic lower limb amputees who use prosthesis.

Detailed description: A cross sectional study based on a retrospective review of prosthetic using major traumatic lower limb amputees' demographic and clinical details together with HRQoL and locomotor capabilities patient-reported outcome measures.

Eligibility criteria: Inclusion Criteria:

1. Below-knee prosthesis users with amputation due to trauma
2. age \>18

Exclusion Criteria:

1. Patients with no prosthesis

Primary outcomes:
measure: The health-related quality of life measured by HRQoL score
timeFrame: 2-5 years
measure: Locomotor capabilities of traumatic below-knee amputees with prothesis
timeFrame: 2-5 years
Secondary outcomes:
measure: 15D health-related quality of life instrument
timeFrame: 2-5 years
measure: Prothesis Evaluation Questionnaire
timeFrame: 2-5 yeats
Other outcomes:
Locations:
city: Helsinki
country: Finland
facility: Helsinki University Central Hospital
state: Uusimaa
Study officials:
affiliation: Helsinki University Central Hospital
name: Erkki J Tukiainen, MD,PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05257863: Development of Machine Learning Models for the Prediction of Complications After Colonic, Colorectal and Small Intestine Anastomosis in Psychiatric and Non-psychiatric Patient Collectives (P-Study)
Official title: Development of Machine Learning Models for the Prediction of Complications After Colonic, Colorectal and Small Intestine Anastomosis in Psychiatric and Non-psychiatric Patient Collectives (P-Study)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Postoperative Complications
Psychosomatic Disorder
Psychiatric Disorder
Cancer
Diverticulitis
Morbus Crohn
Colitis Ulcerosa
Anastomotic Leak
Anastomotic Complication
Small Intestine Anastomotic Leak
Keywords: machine learning
clinical prediction modeling
artificial intelligence
Lead sponsor: University of Basel
Sponsor class: OTHER
Collaborators: name: University of Basel
name: University of Hamburg-Eppendorf
First posted: 2022-02-25
Enrollment: 10000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing colorectal and small intestine surgery.

Brief summary: Our study aims to lay the basis for a predictive modeling service for postoperative complications and prolonged hospital stay in patients suffering from psychiatric diseases undergoing colorectal surgery.

Furthermore, we aim to investigate the impact of preoperative Risk factors, psychiatric and psychosomatic diseases on the outcomes of colorectal surgery and the complications after colorectal surgeries like anastomosis insufficiency via predictive modeling techniques

The service mentioned above will be publicly available as a web-based application


Eligibility criteria: Inclusion Criteria:

* Colocolic, colorectal and small intestine anastomosis
* Neoplasia,
* Diverticulitis
* Mesenteric ischemia
* Iatrogenic or traumatic perforation
* Inflammatory bowel disease

Exclusion Criteria:

* Patients \<18 years
* Patients suffering from recurrent colorectal cancer bearing
* Peritoneal carcinomatosis or unresectable metastatic disease at the time of bowel resection and anastomosis will be excluded.
* Patients who cannot be followed up on for more than six weeks after surgery

Primary outcomes:
measure: Anastomotic insufficiency/leakage
timeFrame: From index surgery up to six weeks postoperatively
measure: Complication after surgery/ Comprehensive Complication Index/ Clavian Dindo Score
timeFrame: From index surgery up to six weeks postoperatively
measure: Length of Hospital Stay (in Days)
timeFrame: From surgery up to 12 weeks postoperatively
measure: Intraoperative influid manangment
timeFrame: Time Frame: From index surgery up to six weeks postoperatively
measure: Development of a preoperative score for morbidity/mortality in colorectal surgery
timeFrame: From index surgery up to six weeks postoperatively
Secondary outcomes:
Other outcomes:
Locations:
city: Basel
country: Switzerland
facility: University of Basel
Study officials:
References:
Clinical trial NCT02271763: Comparing a Horizontal Ultrasound Technique With a Palpation Technique for Localising the Cricothyroid Membrane
Official title: A Descriptive Study Comparing a Horizontal Ultrasound Technique With a Palpation Technique for Localising the Cricothyroid Membrane in an Obstetric Population.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Airway Identification
Keywords: cricothyroid membrane
ultrasound
Lead sponsor: University of British Columbia
Sponsor class: OTHER
First posted: 2014-10-22
Enrollment: 37
Sex: FEMALE
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: The investigators will be comparing a traditional palpation (feeling) technique with an ultrasound technique for finding a specific part of the neck.

Detailed description: This study compares a traditional palpation (feeling) technique with an ultrasound technique for finding a specific part of the neck. Finding this part of the neck is important for anesthesiologists in emergencies and can sometimes be difficult. We would like to determine if using ultrasound is easier and more reliable than examining the neck by hand. Newer methods using ultrasound have not been studied in detail in the pregnant population.

This study aims to describe a simple technique for identifying the cricothyroid membrane. The secondary aim is to determine how ultrasound compares to palpation in pregnant women at term.

Eligibility criteria: Inclusion Criteria:

* term pregnancy
* 19yrs and older

Exclusion Criteria:

* preterm pregnancy

Primary outcomes:
measure: Airway localization
timeFrame: 10 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Vancouver
country: Canada
facility: BC Women's Hospital
state: British Columbia
Study officials:
affiliation: University of British Columbia
name: Simon Massey, MD FRCPC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04293263: The Effect of Shared Listening to Personalized Music on Symptoms of Behavioral Disorders in the Elderly With Advanced Dementia
Official title: The Effect of Shared Listening to Personalized Music on Symptoms of Behavioral Disorders in the Elderly With Advanced Dementia
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Dementia
Keywords: music therapy
Lead sponsor: 2gether
Sponsor class: INDUSTRY
First posted: 2020-03-03
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This study is of great importance because it uses a method that has not been tested in the past. To date, various interventions have been examined that use music for patients with dementia. At the same time, no intervention was conducted that integrates an additional person who shares personalized music with the patient.

If the combination of another person who shares the positive effect of the music with the patient is found to enhance the positive effect of the music, it can change the routine of work with dementia patients and may even reduce the use of tranquilizers among them.

In many cases, it has been found that one of the biggest challenges for family members who treat patients with dementia is the lack of content in the sessions and as a result, the growing sense of alienation between the patient and his family.

Listening to music can be a significant tool in the hands of the family, the main caregiver, the medical staff, and any person who comes in contact with the patient, a tool that can strengthen the sense of connection and connection between them.


Eligibility criteria: Inclusion Criteria:

* Hospitalized in the Department of Mental Disorders at the Mental Health Center in Be'er Sheva aged 18 and over.
* Patients who have been diagnosed with dementia for the issue.
* Patients whose guardian gave consent for the study.

Exclusion Criteria:

* Hearing-impaired patients.

Primary outcomes:
measure: change in BPSD measure among patients in the department. we use the Neuropsychiatric Inventory (NPI) (Cummings et al., 1994.) which detects changes in BPSD.
timeFrame: 8 month
Secondary outcomes:
measure: change in the professional caregivers impression of the treatment
timeFrame: 8 month
measure: change vigor measures of the department's staff (nursing staff)
timeFrame: 8 month
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06982963: RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 2 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FB102 IN ADULT WITH CELIAC DISEASE
Official title: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 2 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FB102 IN ADULT PARTICIPANTS WITH CELIAC DISEASE ON A GLUTEN FREE DIET
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE2
Conditions: Celiac Disease
Lead sponsor: Forte Biosciences, Inc.
Sponsor class: INDUSTRY
First posted: 2025-05-21
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is a randomized, double-blind, placebo controlled clinical study to assess the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of FB102 in adult participants with well controlled (on a strict GFD) CeD following an oral gluten challenge.


Eligibility criteria: Inclusion Criteria:

1. Men and women aged 18 to 70 years at Screening.
2. Has documented diagnosis of CeD confirmed by intestinal biopsy and positive celiac serology at least 12 months prior to Screening (intestinal biopsy and serology do not have to be performed concurrently).
3. Body mass index (BMI) between 16.0 and 40.0 kg/m2, inclusive.
4. Self-reported to be on a GFD for at least 12 months prior to Screening and must be willing to remain on a GFD for the duration of study participation, with the exception of the oral gluten challenge administered as a study procedure. Prior acute and resolved accidental exposures are not exclusionary.

Exclusion Criteria:

1. Uncontrolled CeD and/or active signs/symptoms of CeD, in the opinion of the Investigator.
2. History of or current neuropsychiatric manifestations specifically related to gluten exposure including ataxia, seizures, severe peripheral neuropathy, cognitive impairment, and depression.

Primary outcomes:
measure: Primary Endpoint
timeFrame: 78 Days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01061463: Occupational Cataracts and Lens Opacities in Interventional Cardiology : the O'CLOC Study
Official title: Study of the Occupational Risk of Radiation-induced Cataracts Among Cardiologists
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cataracts
Lens Opacities
Keywords: Radiation cataracts
Lens opacities
X-rays
Interventional Cardiologists
Electrophysiologists
Lead sponsor: Institut de Radioprotection et de Surete Nucleaire
Sponsor class: OTHER_GOV
First posted: 2010-02-03
Enrollment: 250
Sex: ALL
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Interventional and non-interventional cardiologists from public and private French hospitals/facilities, both groups of cardiologists being matched for age and gender.

Brief summary: The purpose of this study is to test the existence of an increased risk of cataracts among interventional cardiologists as compared to cardiologists not exposed to X-rays.

Detailed description: This cross-sectional study includes cardiologists aged \> 40 years: a group of interventional cardiologists (coronary interventionists and electrophysiologists) and a group of unexposed workers (including cardiologists). Individual information, including risk factors of cataracts (age, diabetes, myopia, etc. ...), are collected during a telephone interview. For the exposed group, a specific section of the questionnaire is focused on the occupational history, the description of the procedures (type, frequency, radiation protection tool) and will be used for the classification into "comparable exposure level" groups according to estimates of cumulative dose. For all participants, eye examinations are performed to specifically detect cataracts even in the early stages (lens opacities, LOCS III according to the international standard classification).

Eligibility criteria: Inclusion Criteria:

* aged at least 40 yrs old
* for interventional cardiologists: cumulated number of procedures \> 2000

Exclusion Criteria:

* previous history of medical radiation exposure for radiotherapy or brain scans
* for non-interventional cardiologists: occupational history of interventional cardiologist

Primary outcomes:
measure: Lens opacities
timeFrame: up to 1.5 year
Secondary outcomes:
measure: Visual acuity
timeFrame: up to 1.5 year
measure: Major eye disorders (glaucoma, etc…)
timeFrame: up to 1.5 year
Other outcomes:
Locations:
city: Fontenay-aux-Roses
country: France
facility: IRSN
Study officials:
affiliation: Institut de Radioprotection et de Surete Nucleaire
name: Sophie JACOB, PhD.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jacob S, Michel M, Spaulding C, Boveda S, Bar O, Brezin AP, Streho M, Maccia C, Scanff P, Laurier D, Bernier MO. Occupational cataracts and lens opacities in interventional cardiology (O'CLOC study): are X-Rays involved? Radiation-induced cataracts and lens opacities. BMC Public Health. 2010 Sep 8;10:537. doi: 10.1186/1471-2458-10-537.