louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04888169: Studying the Modification of Attention Bias Remotely After Trauma
Official title: Optimizing Attention Bias Modification for Posttraumatic Stress Disorder: An Entirely Remote Study
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Post Traumatic Stress Disorder
Keywords: Attention bias
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
Collaborators: name: San Francisco Veterans Affairs Medical Center
First posted: 2021-05-17
Enrollment: 1897
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The investigators will complete an entirely remote randomized controlled trial (RCT) comparing 14 sessions of attention bias modification (ABM), attention control training (ACT), placebo neutral attention training, and a final control condition with daily questions in 1,897 individuals with clinically significant Post-traumatic Stress Symptoms (PTSS) (defined as PCL-5 score ≥ 33). To assess effects of the training and control conditions, the investigators will administer tests of threat-related attention bias and variability, and self-report assessments of PTSS, depression, anxiety, and perceived stress at baseline, after one and two weeks of training, and at eight-week follow up. The investigators plan to screen and confirm interest from over 3,000 eligible participants over a period of 24 months to enroll and randomize 1,897 participants with the end goal of 1,232 completers (176 per condition).


Eligibility criteria: Inclusion Criteria:

* Aged 18 to 65 years
* Score at or above 33 on the PCL-5,
* Able and willing to perform daily smartphone training for two weeks
* Fluent English comprehension.
* Owns Android or iPhone smartphone

Exclusion Criteria:

* Does not have Android or iPhone Operating System (iOS) smartphone running sufficient software (i.e. at least iOS 10.1), and is not willing to update
* Active suicidality.

Primary outcomes:
measure: Change in PTSD Checklist-5 (PCL) Score (Before/After Training)
timeFrame: Baseline, 4 weeks
measure: Change in PTSD Checklist-5 (PCL) Score (Follow-up)
timeFrame: 4 weeks, 8 Weeks
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: Tommy Atwater
state: California
Study officials:
affiliation: UCSF, SFVAMC
name: Joshua Woolley, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of California, San Francisco
name: Joaquin Anguera, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02570269: Prospective Comparison of Oral Intubation Via - Ambu® Aura Gain™ vs Slotted Guedel Tubus
Official title: Prospective Randomized Comparison Between a Flexible Fiberoptic Intubation Via the Ambu® Aura Gain™ Airway and the Slotted Guedel Tubus in Terms of Time to a Completed Airway Management and Patient Safety.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Adverse Anesthesia Outcome
Lead sponsor: Schulthess Klinik
Sponsor class: OTHER
First posted: 2015-10-07
Enrollment: 94
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study has to show that an intubation with the AuraGain Laryngeal mask could bring the same benefits in terms of intubation in clinical practice, as the slotted Guedel tubus.


Eligibility criteria: Inclusion Criteria:

* Aged ≥18
* ASA 1 -2
* Surgery of the shoulder, elbow, hand, hip, knee or foot
* Signed consent form

Exclusion Criteria:

* Patients with expected difficulties regarding to the intubation
* Patients with diseases / anatomical changes in the area of the pharynx, the larynx, the trachea, the esophagus or the stomach
* Not sober
* Increased risk of aspiration
* BMI \> 35 kg/m2
* Acute disease which could affect the suitability of the anesthesia
* Patients in which the use of a laryngeal mask is contraindicated or otherwise not possible
* Patients with a disease which prevents an accurate examination of the patients (eg neuromuscular, mentally, metabolic disease)
* Drug abuse in the recent past
* Legal incompetence

Primary outcomes:
measure: Intubation time
timeFrame: Intraoperative
Secondary outcomes:
measure: Intubation attempts
timeFrame: Intraoperative
measure: Esophagal Intubation attempts
timeFrame: Intraoperative
measure: Resistance measurement of the Insertion as assessed by a four point scoring system
timeFrame: Intraoperative
measure: Position of the mask as assessed by the Brimacombe Score
timeFrame: Intraoperative
measure: Pain after Intubation as assessed by a Numeric Rating Scale
timeFrame: Intraoperative/2h postoperative/24h postoperative
measure: AE/Complications
timeFrame: Intraoperative/postoperative until 24h
Other outcomes:
Locations:
city: Zürich
country: Switzerland
facility: Schulthess Klinik
Study officials:
affiliation: Schulthess Klinik
name: Berthold Moser, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Moser B, Audige L, Keller C, Brimacombe J, Gasteiger L, Bruppacher HR. Flexible bronchoscopic intubation through the AuraGain laryngeal mask versus a slit Guedel tube: a non-inferiority randomized-controlled trial. Can J Anaesth. 2017 Nov;64(11):1119-1128. doi: 10.1007/s12630-017-0936-7. Epub 2017 Jul 17.
Clinical trial NCT06228469: Cytolytic Vaginosis Multicentre Registry
Official title: Cytolytic Vaginosis Multicentre Registry
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cytolytic Vaginosis
Keywords: Vaginitis
Lactobacillus
Wet mount
Vaginal microbiome
Fragmented epithelial cells
Vaginal discharge
Lead sponsor: University of Alberta
Sponsor class: OTHER
First posted: 2024-01-29
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women attending an outpatient clinic with vaginitis symptoms

Brief summary: The goal of this registry is to learn more about cytolytic vaginosis, a little known and controversial condition. The main questions the registry aims to answer are:

* What are risk factors of cytolytic vaginosis?
* Are there defining symptoms of cytolytic vaginosis?
* What features on wet mount should be used to diagnosis cytolytic vaginosis?
* Are baking soda vaginal irrigations an effective treatment for cytolytic vaginosis?
* Do characteristics of cytolytic vaginosis vary between sites/countries?

Detailed description: Cytolytic vaginosis is a largely unknown, debated, and equivocal vaginal condition. It is unclear whether cytolytic vaginosis is a variant of normal vaginal microbiome or should be considered a vaginal dysbiosis condition, similar to bacterial vaginosis. This multicentre registry will enroll women that have signs/symptoms consistent with cytolytic vaginosis to better characterize it.

Women at participating sites diagnosed with cytolytic vaginosis and that provide consent will be consecutively enrolled in the registry. The registry will capture data on risk factors, symptoms, test results (eg, wet mount) and treatment outcomes.

Eligibility criteria: Inclusion Criteria:

* Vaginitis symptoms
* Predominately lactobacilli or/and elongated lactobacilli on wet mount
* Cytolysis on wet mount

Exclusion Criteria:

* Unable to consent or decline consent
* Pregnant
* Positive for yeast (culture or PCR)

Primary outcomes:
measure: Characterize cytolytic vaginosis
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Niterói
country: Brazil
facility: Universidade Federal Fluminense-UFF
state: Rio De Janeiro
city: Multiple Locations
country: Canada
facility: Outpatient clinics
state: Alberta
city: Porto
country: Portugal
facility: Centro Hospitalar de São João
Study officials:
References:
Clinical trial NCT03537469: Neuromodulation With Low Frequency-Pulsed Electromagnetic Fields
Official title: Modulation of Long-Term Potentiation-Like Cortical Plasticity in the Healthy Brain With Low Frequency-Pulsed Electromagnetic Fields
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Electromagnetic Fields
Neuronal Plasticity
Transcranial Magnetic Stimulation
Lead sponsor: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Sponsor class: OTHER
First posted: 2018-05-25
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: Non-depolarizing magnetic fields, like Low Frequency-Pulsed Electromagnetic Fields (LF-PEMFs) have shown the ability to modulate living structures, principally by influencing synaptic activity and ion channels on cellular membranes. Recently, the CTU Mega 20 device was presented as a molecular accelerator, using energy up to 200 Joules and providing high-power (2 Tesla) pulsating fields with a water-repulsive (diamagnetic) action and tissue biostimulation. The investigators tested the hypothesis that LF-PEMFs could modulate long-term corticospinal excitability in healthy brains by applying CTU Mega 20®. Ten healthy subjects without known neurological and/or psychiatric diseases entered the study. A randomized double-blind sham-controlled crossover design was employed, recording TMS parameters (amplitude variation of the motor evoked potential as index of cortical excitability perturbations of the motor system) before (pre) and after (post +0, +15, +30 min) a single CTU Mega 20 session on the corresponding primary right-hand motor area, using a real (magnetic field = 2 Tesla; intensity = 90 J; impulse frequency = 7Hz; duration = 15 minutes) or sham device. A two-way repeated measures ANOVA with TIME (pre, post +0, +15, +30 min) and TREATMENT (real vs sham stimulation) as within-subjects factor was applied.


Eligibility criteria: Inclusion Criteria:

* Healthy subjects between 18 and 35 years

Exclusion Criteria:

* Known neurological or psychiatric diseases

Primary outcomes:
measure: Cortical Excitability change across time
timeFrame: Baseline and after 15, and 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: U.O. Neurologia Vascolare, Azienda Ospedaliera Spedali Civili, Brescia
name: Mauro Magoni, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Premi E, Benussi A, La Gatta A, Visconti S, Costa A, Gilberti N, Cantoni V, Padovani A, Borroni B, Magoni M. Modulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pulsed electromagnetic fields. BMC Neurosci. 2018 Jun 13;19(1):34. doi: 10.1186/s12868-018-0434-z.
Clinical trial NCT03984669: (1,3)-Béta-D-Glucan Levels at Diagnosis of Juvenile Idiopathic Arthritis and Its Correlation With Activity's Disease : a Cohort Sudy
Official title: (1,3)-Béta-D-Glucan Levels at Diagnosis of Juvenile Idiopathic Arthritis and Its Correlation With Activity's Disease : a Cohort Sudy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Juvenile Idiopathic Arthritis
Keywords: juvenile idiopathic arthritis
(1,3)-beta-D-glucan
children
inflammatory status
intestinal microbiota
activity od the disease
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2019-06-13
Enrollment: 40
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease of childhood. Most children still experience prolonged periods of active disease, however, there is still lack of effective and specific markers for early diagnosis of relapse. The pathogenesis of JIA is thought to be the result of a combination of host genetic and environmental triggers and The microbiota is a potential contributing factor to the development of the disease. (1-3)-ß-D-Glucan (BDG), a component of most fungal cell walls, possess immunomodulatory activities. Latest studies demonstrate that it acts as a trigger for autoimmune arthritis in adult. However the relation with JIA is not clearly defined. The objective of this study was to evaluate the (1,3)-Béta-D-Glucans level in patients with JIA and whether higher serum BDG levels are correlated with JIA activity of disease, comparatively with usual markers.


Eligibility criteria: Inclusion Criteria:

* All patients under the age of 18 years with JIA's disease
* followed at the CHU Amiens (French University hospital)
* signed parent consent form

Exclusion Criteria:

* lack of consent from parents or patient

Primary outcomes:
measure: Measure of (1,3)-Beta-D-Glucans level in patients with Juvenile Idiopathic Arthritis
timeFrame: one year
Secondary outcomes:
measure: Correlation of (1,3)-Beta-D-Glucans level in patients with Juvenile Idiopathic Arthritis score (JADAS)
timeFrame: one year
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens
Study officials:
affiliation: CHU Amiens
name: Djamal-Dine Djeddi, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: CHU Amiens
name: Taieb Chouaki, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04153669: Exercise With or Without Electrical Stimulation in Cystic Fibrosis (Part I): Effects on Physical Fitness
Official title: Effects of Exercise With or Without Electrical Stimulation in Physical Fitness in Cystic Fibrosis: an Integrated Vision (ECOMIRIN Study)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cystic Fibrosis in Children
Keywords: Cystic Fibrosis
Electrostimulation
Combined Training
Physical Fitness
Lead sponsor: Universidad Europea de Madrid
Sponsor class: OTHER
First posted: 2019-11-06
Enrollment: 27
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to assess the effects of programmed exercise with or without electrical stimulation in the cardiorespiratory fitness, strength, functional capacity and agility in a group of young patients with Cystic Fibrosis: A randomized controlled trial comparing two interventions with a control group.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of CF
* Age: 6-18 years old
* Signature of informed consent of legal guardian and patient.

Exclusion Criteria:

* Being a smoker
* Having had an exacerbation in the last 3 months
* Having undergone gastric surgery
* Having enteral nutrition at present
* The patients will come from the HIUNJ of Madrid.
* Currently taking CFTR modulators

Primary outcomes:
measure: Change in Strength
timeFrame: Two assessment points throughout the study: baseline and 8 weeks after the intervention
Secondary outcomes:
measure: Change in Cardiorespiratory Fitness
timeFrame: Two assessment points throughout the study:baseline and 8 weeks after the intervention
measure: Changes in Pulmonary Function
timeFrame: Two assessment points throughout the study:baseline and 8 weeks after the intervention
measure: Changes in physical activity levels
timeFrame: Two assessment points throughout the study:baseline and 8 weeks after the intervention
measure: Change in quality of life
timeFrame: Two assessment points throughout the study:baseline and 8 weeks after the intervention
measure: Food consumption frequency
timeFrame: One assessment point at baseline:baseline and 8 weeks after the intervention
Other outcomes:
Locations:
city: Villaviciosa De Odón
country: Spain
facility: Escuela de Doctorado e Investigacion, Universidad Europea
Study officials:
affiliation: Universidad Europea de Madrid
name: Margarita Perez Ruiz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06730269: Face-to-Face Vs. Telerehabilitation for Thoracic Hyperkyphosis in Children: a Clinical Trial
Official title: Comparative Efficacy of Face-to-Face and Telerehabilitation Approaches in Managing Thoracic Hyperkyphosis Among 9-12-Year-Olds: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Kyphosis Thoracic
Hyperkyphosis
Keywords: Thoracic hyperkyphosis
face-to-face rehabilitation
telerehabilitation
spinal posture
musculoskeletal health
corrective exercises
Pediatric Kyphosis
Lead sponsor: Medipol University
Sponsor class: OTHER
First posted: 2024-12-12
Enrollment: 20
Sex: ALL
Minimum age (years): 9
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluates the effectiveness of face-to-face versus telerehabilitation programs for children aged 9-12 with thoracic hyperkyphosis, a condition caused by poor posture that leads to excessive forward curvature of the spine. Twenty children participated in a six-week corrective exercise program, either in person or through an online platform. Both approaches significantly improved spinal posture, back muscle strength, and pain levels, with no notable differences in outcomes between the two methods. The findings suggest that telerehabilitation is as effective as face-to-face rehabilitation, offering a flexible option for managing thoracic hyperkyphosis in children.


Eligibility criteria: Inclusion Criteria:

* Children aged 9-12 years.
* Diagnosed with thoracic hyperkyphosis (Thoracic Kyphosis Angle \> 40 degrees).
* Able to participate in a 6-week rehabilitation program (face-to-face or telerehabilitation).

Exclusion Criteria:

* Children with congenital spinal malformations.
* Children with mental health issues that could interfere with participation or compliance in the study.

Primary outcomes:
measure: Thoracic Kyphosis Angle (TKA)
timeFrame: 6 weeks
measure: Manual Muscle Test (MMT)
timeFrame: 6 weeks
measure: Visual Analog Scale (VAS)
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Istanbul Medipol University
state: Kavacık
Study officials:
affiliation: Medipol University
name: Seda Gözener Canbülbül
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yang L, Lu X, Yan B, Huang Y. Prevalence of Incorrect Posture among Children and Adolescents: Finding from a Large Population-Based Study in China. iScience. 2020 May 22;23(5):101043. doi: 10.1016/j.isci.2020.101043. Epub 2020 Apr 8.
citation: Feng Q, Wang M, Zhang Y, Zhou Y. The effect of a corrective functional exercise program on postural thoracic kyphosis in teenagers: a randomized controlled trial. Clin Rehabil. 2018 Jan;32(1):48-56. doi: 10.1177/0269215517714591. Epub 2017 Jun 14.
Clinical trial NCT00470769: The Efficacy of Color-Doppler Ultrasonography to Assess the Renal Blood Flow With the Estimation of GFR
Official title: Color-Doppler Ultrasonography vs 99mTc-DTPA Scintigraphy to Assess the Renal Blood Flow
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hypertension
Renal Failure
Keywords: Color-Doppler Ultrasonography
Renal scintigraphy
Kidney failure
GFR
Lead sponsor: University of Roma La Sapienza
Sponsor class: OTHER
First posted: 2007-05-08
Enrollment: 2006
Sex: ALL
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: DEFINED_POPULATION
Time perspective: OTHER

Brief summary: It is generally assumed that renal blood flow is symmetric in the absence of renal artery stenosis. The importance of studying the function of both kidneys separately is because it cannot be assumed that they are functionally equal.The aim of the present study is to evaluate whether this is really in patients with essential hypertension and/or moderate kidneys loss.

Detailed description: To validate color Doppler ultrasonography of renal arteries for the assessment of renal blood flow (RBF), we comparing left and right RBF estimates and their sum (total RBF) by echo-Doppler with data obtained by 99mTc-DTPA scintigraphy in 50 patients with hypertension and/or moderate renal failure, compared with 30 normal control subjects.

Eligibility criteria: Inclusion Criteria:

* Patients with hypertension
* Patients with moderate renal insufficiency
* Normal subjects

Exclusion Criteria:

* Patients with solitary kidney function
* Patients with renal artery stenosis
* Patients underwent renal angioplasty and stenting

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Catanzaro
country: Italy
facility: Giorgio Fuiano
city: Roma
country: Italy
facility: University of Rome La Sapienza
city: Rome
country: Italy
facility: Rosario Cianci
Study officials:
affiliation: Department Of Clinic Medicine, Chair of Nephrology
name: Rosario Cianci, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Catanzaro
name: Giorgio Fuiano, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05467969: Teleteaching on Clinical Procedural Skills
Official title: Online Teleteaching and Teleassessment on Clinical Procedural Skills Via Multiscreen Display Layout: A Prospective Observational Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Competence
Educational Problems
Keywords: Clinical Competence
Education, Distance
Education, Medical
Motor Skills
Teaching
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2022-07-21
Enrollment: 18
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Medical doctors (General Practitioners or Residents in Plastic Surgery Training)

Brief summary: This study aims to develop a model of teleteaching and teleassessment for clinical procedural skills, consisted of teleteaching design making and teleteaching intervention was conducted in September 2020 - February 2021 at a tertiary center Dr. Cipto Mangunkusumo Hospital/ Faculty of Medicine Universitas Indonesia.

Detailed description: Six plastic surgery residents and 12 general practitioners voluntarily participated in 3 different workshops. Three workshops on different procedural skill sets were conducted by including surgical knotting skills, suturing techniques and basic laparoscopic hand-eye coordination skills. A group of participants learned the skills on site, while another group joined the workshop synchronously through the online multiscreen display teleconference platform. The teaching effectiveness was assessed using pre-post written test, OSATS, GRS and self-efficacy. Online skills teleassessment was also compared to the asynchronous assessment based on pre-recorded videos.

Eligibility criteria: Inclusion Criteria:

* Medical doctors (General Practitioners or Residents in Plastic Surgery Training) who volunteered to join the workhops

Exclusion Criteria:

* Participants who do not consent to join the workshops

Primary outcomes:
measure: Multiscreen display layouts created from multicamera configurations
timeFrame: 2 months
measure: Pre-post written test scores
timeFrame: Through study completion, an average of 6 weeks
measure: Objective Structured Assessment of Technical Skills (OSATS) Score
timeFrame: Through study completion, an average of 6 weeks
measure: Global Rating Scale (GRS)
timeFrame: Through study completion, an average of 6 weeks
Secondary outcomes:
measure: Self Efficacy Scale
timeFrame: Through study completion, an average of 6 weeks
Other outcomes:
Locations:
city: Jakarta Pusat
country: Indonesia
facility: Indonesia University
state: DKI Jakarta
Study officials:
affiliation: Indonesian Clinical Training and Education Centre (ICTEC), Faculty of Medicine, Universitas Indonesia
name: Theddeus Prasetyono, M.D, Ph.D
role: PRINCIPAL_INVESTIGATOR
References: