Clinical trial NCT02844374: Epileptogenic Zone's Cartography by Quantification of EEG's Signal and Intracerebral Stimulation.
Official title: Epileptogenic Zone's Cartography by Quantification of EEG's Signal and Intracerebral Stimulation.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Epilepsy
Keywords: Epilepsy
Surgery candidate
EEG's Signal
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2016-07-26
Enrollment: 45
Sex: ALL
Minimum age (years): 5
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP

Brief summary: Epilepsy is a devastating chronic disease due to multiple causes that affect close to 50% of the world's population.

Although effective, epilepsy surgery fails in many cases, the percentage of patients free from crisis on a long term (≥ 5 years) varies from 27% to 66% according to the kind of epilepsy.

It is in this context that EPISTIM is interesting, and its aims isb a better electrophysiology delimiting of cortical networks that imply the genesis of seizures with the aim to improove surgery results.

This study will rely on the intracerebral records and on corticales electrical stimulation as they are currently routinely used by epileptic patients candidates for surgery.


Eligibility criteria: Inclusion Criteria :

* Patient from 5 to 65 years (L1121-7 L1122 2 CSP), including legally protected or unable to give his consent (L1121-8 CSP).
* Written approval of inclusion in the study from the patient or his legal representative.
* Patients with partial Epilepsy Drug Resistant , justifying a SEEG exploration.

Exclusion Criteria :

* Patient under 5 years.
* Patient over 65 years.
* Pregnant or breastfeeeding women (L1121-5 CSP).
* Patient deprived of liberty as a result of a judicial or administrative decision (L1121-6 CSP).
* Patients over 18 years unable to give their free consent and not subject to a legal protection order.

Primary outcomes:
measure: Visual analysis
timeFrame: up to one hour
measure: Epileptogenic maps
timeFrame: up to 10 min
measure: Connectivity maps
timeFrame: up to 10 min
measure: MRI
timeFrame: up to one hour
Secondary outcomes:
Other outcomes:
Locations:
city: La Tronche
country: France
facility: UniversityHospitalGrenoble
Study officials:
affiliation: Grenoble Hospital University
name: Philippe Kahane, Professor
role: PRINCIPAL_INVESTIGATOR
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