Clinical trial NCT06279039: Clinical Observation of Exosomes in Patients After Q-switched Laser Surgery
Official title: Clinical Observation of Exosomes in Patients After Q-switched Laser Surgery
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Exosome
Skin Regeneration
Laser
Keywords: Exosome
Q-switched laser
Lead sponsor: Nanjing First Hospital, Nanjing Medical University
Sponsor class: OTHER
First posted: 2024-02-26
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: the goal of this half-face controlled study is to evaluate the effect of exosome-containing liquid dressings on the recovery of patients after Nd:YAG laser 532 treatment.

Detailed description: The main objective was to collect patients with fleae or seborrheic keratosis after Q-switched laser treatment, and then to use exosomes or matrix on both sides of the face, and finally to evaluate the effect of exosomes on wound healing and prevention of post-inflammatory hyperpigmentation after Nd:YAG laser 532 treatment

Eligibility criteria: Inclusion Criteria:

* It meets the diagnostic criteria of seborrheic keratosis or freckle；
* pepole are able to follow the treatment rules of the study and were followed up for 8 weeks；
* informed consent

Exclusion Criteria:

* History of keloids ;
* Pregnancy or lactation;
* Any cosmetics containing growth factor-related ingredients used within 6 months prior to treatment
* Patients with incomplete observation data and incomplete course of treatment were excluded

Primary outcomes:
measure: Global Aesthetic Improvement Scale score
timeFrame: 1, 3.5, 7, 14, 28, and 56 days
measure: Dermatology Quality of life index
timeFrame: 1, 3.5, 7, 14, 28, and 56 days
Secondary outcomes:
measure: post-inflammatory hyperpigmentation
timeFrame: 2.4,8 weeks
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Jie Dai
state: Jiangsu
Study officials:
affiliation: The First Affiliated Hospital with Nanjing Medical University
name: Jie Dai
role: PRINCIPAL_INVESTIGATOR
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