Clinical trial NCT04077320: Neurological Changes With a Memory Self-efficacy Training Protocol
Official title: Neurological Changes With a Memory Self-efficacy Training Protocol
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mild Cognitive Impairment
Keywords: memory
older adults
randomized control trial
MRI
memory education
Lead sponsor: Western University, Canada
Sponsor class: OTHER
Collaborators: name: Western BrainsCAN
First posted: 2019-09-04
Enrollment: 28
Sex: ALL
Minimum age (years): 60
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Confidence in one's ability to accomplish a task, more formally known as self-efficacy, is an important psychological variable that can influence how the investigators perform on various tasks. Previous studies have shown that self-efficacy is a modifiable trait that can be improved and bolstered with training and practice. More importantly for this study, memory self-efficacy has been shown to be modifiable for older adults, consequently improving their performance on memory tasks. While there is evidence to support the importance of memory self-efficacy for successful memory performance in older adults, the underlying neurological changes that accompany these performance changes have not been explored. The goal of this study is to examine the changes in brain activity before and after a memory self-efficacy training program to better understand the mechanisms of both memory and self-efficacy.


Eligibility criteria: Inclusion Criteria:

1. Subjective memory complaints within past 5 years
2. Objective memory impairment below age norms on standardized cognitive testing
3. Score below 25 on Montreal Cognitive Assessment
4. Scores 1.5 standard deviations below age norms on memory testing
5. Unimpaired performance in Activities of Daily Living
6. Intact general cognition
7. Fluently read, write and speak English
8. Right handed

Exclusion Criteria:

1. Co-morbidity that would impact cognition (depression, anxiety, stroke)
2. Prior diagnosis of dementia of any type
3. Use of prescription or recreational drug use that would impact cognition (excluding hormone replacement therapy)
4. Uncorrected visual or auditory deficits/impairments
5. Current participation in alternate study

Primary outcomes:
measure: Neurological bio-markers: Regional activation
timeFrame: Pre and Post intervention - 6 weeks
measure: Neurological bio-markers: Default mode network
timeFrame: Pre and Post intervention - 6 weeks
Secondary outcomes:
measure: Story Recall - Trained memory performance task
timeFrame: Pre and Post intervention - 6 weeks
measure: List Recall - Trained memory performance tasks
timeFrame: Pre and Post intervention - 6 weeks
measure: Face-Name Pairs - Trained memory performance tasks
timeFrame: Pre and Post intervention - 6 weeks
measure: RAVLT - Untrained memory performance tasks
timeFrame: Pre and Post intervention - 6 weeks
measure: Visual Spatial Learning Task - Untrained memory performance tasks
timeFrame: Pre and Post intervention - 6 weeks
measure: Digit Span Task - Untrained memory performance tasks
timeFrame: Pre and Post intervention - 6 weeks
measure: Face-Scene Pairs - Untrained memory performance tasks
timeFrame: Pre and Post intervention - 6 weeks
Other outcomes:
measure: Memory self-efficacy: Multifactorial Memory Questionnaire (MMQ)
timeFrame: Pre and Post intervention - 6 weeks
measure: Memory self-efficacy: Memory Self-efficacy Questionnaire (MSEQ) subjective scale
timeFrame: Pre and Post intervention - 6 weeks
Locations:
city: London
country: Canada
facility: Community
state: Ontario
Study officials:
References: