louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00512369: Effects of PA-1 Transcriptional Regulation on Monocyte Function
Official title: Angiotensin, the Vascular Endothelium, and Fibrinolysis - The Effects of PAI-1 Transcriptional Regulation on Human Monocyte Function
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Atherosclerosis
Keywords: Metabolic pathways
Atherosclerosis
Monocyte Function
Lead sponsor: Vanderbilt University
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2007-08-07
Enrollment: 125
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Obese men and women

Brief summary: Researching genetic differences in people with no prior medical conditions for better understanding of cardiac diseases through genetic research.

Detailed description: The discovery and subsequent application of small interfering RNA (siRNA) methods to achieve individual gene silencing in mammalian cells is a robust method that is well-described and validated in mammalian cell culture systems. We will apply this technique to achieve post-transcriptional "silencing" of PAI-1 in monocytes obtained from otherwise healthy volunteers, and study the subsequent loss of this gene's function on the migratory capacity of these cells in the proposed in vitro experimental system. This concept has not yet been demonstrated in the literature, and if validated, would be a novel and fundamental description of the role of PAI-1 in human monocyte biology as related to the development of atherosclerosis.

Eligibility criteria: Inclusion Criteria:

* Ages 18 -50
* No current or past medical problems

Exclusion Criteria:

* Patients taking prescription drugs (hormonal birth control or herbal supplements may be taken.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
Study officials:
affiliation: Vanderbilt University
name: Mohan Sathyamoorthy, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02575469: Exercise Capacity in Diseases and Health
Official title: Exercise Capacity in Diseases and Health
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Exercise Capacity
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2015-10-14
Enrollment: 500
Sex: ALL
Minimum age (years): 6
Maximum age (years): 90
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 500 Patients evaluated routinely in the exercise lab (pediatric cardiology institute) and healthy volunteers evaluated as controls.

Brief summary: Exercise capacity is a key factor to evaluate and treat patients in different diseases (e.g. ischemic heart disease, chronic obstructive pulmonary disease, cystic fibrosis). The best way to measure exercise capacity is to perform a cardiopulmonary exercise testing. Normal/reference values in health and disease relate to specific population and subpopulations. The population in Israel is unique in its diversity.

Objectives: Data collection of exercise capacity assessment in health and illness in the northern of Israel for future local database.

Population: 500 Patients evaluated routinely in the exercise lab (pediatric cardiology institute) and healthy volunteers evaluated as controls.

Study design: Prospective observational study. Participants will answer a health related questioner, undergo a physical examination, perform a cardiopulmonary exercise test on a treadmill or a cycle ergometer.

Detailed description: Exercise capacity is a key factor to evaluate and treat patients in different diseases (e.g. ischemic heart disease, chronic obstructive pulmonary disease, cystic fibrosis). The best way to measure exercise capacity is to perform a cardiopulmonary exercise testing. Normal/reference values in health and disease relate to specific population and subpopulations. The population in Israel is unique in its diversity.

Objectives: Data collection of exercise capacity assessment in health and illness in the northern of Israel for future local database.

Population: 500 Patients evaluated routinely in the exercise lab (pediatric cardiology institute) and healthy volunteers evaluated as controls.

Study design: Prospective observational study. Participants will answer a health related questioner, undergo a physical examination, perform a cardiopulmonary exercise test on a treadmill or a cycle ergometer .

Eligibility criteria: Inclusion Criteria:

* Ability to complete full exercise evaluation (including cardiopulmonary exercise testing).

Exclusion Criteria:

* Acute illness on visit day.
* for healthy volunteers: chronic disease or use of medications.
* Professional athletes.

Primary outcomes:
measure: VO2 (oxygen consumption)
timeFrame: 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: RAMBAM health care center
Study officials:
References:
Clinical trial NCT02412969: Impact of Dural Puncture Epidural Versus Traditional Lumbar Epidural on Onset of Labor Analgesia
Official title: Impact of Dural Puncture Epidural Versus Traditional Lumbar Epidural on Onset of Labor Analgesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Labor Pain
Labor Analgesia
Lead sponsor: Medical University of South Carolina
Sponsor class: OTHER
First posted: 2015-04-09
Enrollment: 101
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is to examine the onset of pain relief with two different methods of labor epidural. The traditional labor epidural involves the placement of numbing and anti-pain medicine in the epidural space which surrounds the spinal cord. In order to take effect, the medication has to cross a layer of tissue called the dura. In the current study, the same medications are placed in the epidural space after the dura is punctured with a fine needle. This research, will help evaluate whether this technique will result in earlier onset of pain relief.


Eligibility criteria: Inclusion Criteria:

* Pregnant patients in active painful labor
* ASA I and II parturients
* Women Ages 18+ to 40
* Patients who have labor epidural as part of their labor plan will be recruited

Exclusion Criteria:

* Patients admitted to the Labor and Delivery Suite who are committed to have a delivery with the current admission but who do not want a labor epidural
* Patients with the following: bleeding disorders, infection at the site of epidural placement, generalized sepsis, stenotic heart valve lesions, increased intracranial pressure, patients with hypovolemia, and patient refusal
* Parturients with chronic pain syndromes
* Patients on MAO inhibitors
* Patients with allergies to bupivacaine and fentanyl (and other amide local anesthetics) patients with substance abuse history will be excluded
* Non English-speaking patients will be excluded

Primary outcomes:
measure: Compare time of onset of labor analgesia Dural Puncture vs Lumbar Puncture
timeFrame: two days post delivery
Secondary outcomes:
measure: Incidence of Side Effect
timeFrame: two days post delivery
Other outcomes:
Locations:
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
Study officials:
References:
Clinical trial NCT04456946: Prospective Investigation of the Effects of Different Treatment Techniques on Myofascial Trigger Points in Patients With Temporomandibular Dysfunction (TMD)
Official title: Prospective Investigation of the Effects of Different Treatment Techniques on Myofascial Trigger Points in Patients With Temporomandibular Dysfunction (TMD)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Low Level Laser and Occlusal Splint
Keywords: Low Level Laser
Occlusal Splint
Temporomandibular Disfunction
Lead sponsor: Istanbul University
Sponsor class: OTHER
First posted: 2020-07-07
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In the literature, there are no studies comparing the use of occlusal splint and Low Level Laser (LLL) in the treatment of Temporomandibular Disfunction (TMD) and including Ultrasonography (USG) in these parameters. In this study, it is aimed to contribute to the literature in terms of determining which treatment method is more effective by evaluating the changes in the needles muscles with the use of occlusal splints and LLL with USG and other parameters in certain periods, as well as evaluating which parameters are more effective.


Eligibility criteria: Inclusion Criteria:

* Patients over the age of 18 who apply with Temporomandibular Joint (TMJ) problems
* Patients with pain in the joint and chewing muscle area

Exclusion Criteria:

* Syndromic patients
* Patients under the age of 18
* Patients with a history of orthognathic surgery
* Pregnants
* Antidepressant Users
* Patients Using Removable Dentures
* Patients who have had joint treatment in the past six months

Primary outcomes:
measure: Joint Pain Scale
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul University, Dentistry Faculty
state: Fatih
Study officials:
affiliation: Biruni University
name: Ahmet Faruk Erturk, Assistant Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02838446: Effectiveness of Graded Motor Imagery to Improve Hand Function in Patients With Distal Radius Fracture
Official title: Cognitive Therapy Model: Graded Motor Imagery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Distal Radius Fracture
Pain
Lead sponsor: Hacettepe University
Sponsor class: OTHER
Collaborators: name: Medipol University
First posted: 2016-07-20
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to investigate of the effectiveness of Graded Motor Imagery (GMI) on hand functionality in patients with Distal Radius Fracture (DRFx). This study was carried out on 36 patients. These patients were randomly assigned to two groups: classic treatment group (n=19) and GMI group (n=17). Both groups received a 8-week (2 days a week) physical therapy and rehabilitation intervention. Outcome measurements were based on upper extremity functional status (Disability of the Arm Shoulder Hand and Michigan Hand Questionnaire scores), pain (on the rest and during the activity with Visual Analog Scale), range of motion (wrist flexion, extension, ulnar/radial deviation, supination and pronation with goniometer), grip strength (standard grip strength with Jamar hydraulic hand dynamometer; lateral, palmar and pinch strength with pinch meter).


Eligibility criteria: Inclusion Criteria:

* ages between 18-65 years
* diagnosed with DRFx which is extra-articular
* managed with pins, internal fixation and/or cast

Exclusion Criteria:

* unwilling or unable to participate
* intra-articular and instable fractures containing other part of the fractures
* fractures related with the malignancy and other neurologic diseases
* existing inflammatory joint condition,
* lack of cognitive function.

Primary outcomes:
measure: Physical Function and Symptoms
timeFrame: 8 weeks
Secondary outcomes:
measure: Pain intensity
timeFrame: 8 weeks
measure: Normal range of motion
timeFrame: 8 weeks
measure: Grip Strength
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Medipol University
Study officials:
References:
Clinical trial NCT03342846: High Versus Low Frequency rTMS on Motor Dysfunction in PD
Official title: The Effect of High Versus Low Frequency Repetitive Transcranial Magnetic Stimulation on Motor Dysfunction in Parkinson's Disease; Which is More Beneficial?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson Disease
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-11-17
Enrollment: 40
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD. Forty patients with PD participated in the study.

The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd one received 20 Hz rTMS daily for 10 days 5 sessions every week. The doctors who assess the patients clinically is blind for the frequency of rTMS, also patients don't know which type of stimulation they received. The patients were followed up before and after the 10 sessions and one month later.

Detailed description: The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD. Forty patients with PD participated in the study.

The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd one received 20 Hz rTMS daily for 10 days 5 sessions every week and 2 days off per week. The doctors who assess the patients clinically is blind for the frequency of rTMS, also patients don't know which type of stimulation they received. The patients were followed up before and after the 10 sessions and one month later.

Eligibility criteria: Inclusion Criteria:

* All PD patients who were diagnosed according to UK bank criteria for PD.

Exclusion Criteria:

* History of repeated head injury.
* History of repeated cerebrovascular strokes
* History of defined encephalitis
* Oculogyric crisis, supra nuclear gaze palsy.
* Family history of more than one relative
* severe dementia, MMSE \< 23, severe depression
* Cerebellar signs
* Babiniski sign
* Hydrocephalus or intracranial lesion on neuroimaging
* Patients with intracranial on neuroimaging
* Patients with intracranial metallic device or pacemaker
* Patients who were unable to give informed consent because of severe anesthesia, or cognitive deficit

Primary outcomes:
measure: change in motor disability
timeFrame: one month
Secondary outcomes:
measure: Changes in Cortical excitability
timeFrame: Two weeks
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Eman Khedr
Study officials:
affiliation: Professor of Neurology, Faculty of Medicine, Assiut University
name: eman M Khedr, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05883046: The Acute Effects of Combined Caffeine and Sodium Bicarbonate Consumption on Isometric Mid-thigh Pull
Official title: The Acute Effects of Pre-Exercise Isolated and Combined Caffeine and Sodium Bicarbonate Consumption on Isometric Mid-thigh Pull Performance: A Placebo-Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Athletes
Keywords: Caffeine
Sodium Bicarbonate
Isometric Contraction
Performance-Enhancing Substances
Lead sponsor: Bozok University
Sponsor class: OTHER
First posted: 2023-05-31
Enrollment: 19
Sex: ALL
Minimum age (years): 18
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: subjects participated under 5 crossover conditions: control (without supplement) (Con), placebo (maltodextrin) (Pla), caffeine (Caf), sodium bicarbonate (NaHCO3) and caffeine+sodium bicarbonate (Caf+NaHCO3). The control measurement was made as a baseline measurement without supplementation.
Primary purpose: OTHER

Brief summary: The aim of this study was to investigate the effects of isolated and combined caffeine and sodium bicarbonate consumption on acute isometric mid-thigh pull (IMTP) strength, and verify whether they are cumulative, neutral or subtractive.

Detailed description: Method: Nineteen Sport Sciences Faculty students (Age 23.6±1.6 years, height 171±9.4 cm, weight 64.3±9.6 kg, fat percentage 20.5±7.3 %, BMI 21.7±2.4 kg/m2) participated and completed the intervention. This study was designed as crossover, double-blind and placebo-controlled. Subjects participated under 5 crossover conditions: control (without supplement) (Con), placebo (Pla), caffeine (Caf), sodium bicarbonate (NaHCO3) and caffeine+sodium bicarbonate (Caf+NaHCO3). For Caf conditions, participants consumed 6 mg/kg of caffeine, obtained from dosing the content of 200 mg capsules. As for NaHCO3 conditions, participants consumed 0.3 g/kg of sodium bicarbonate dissolved in water. For the combined condition, (Caf+NaHCO3), intake was set at 6 mg of caffeine and 0.3 g of sodium bicarbonate per kilogram of body weight. All supplements were consumed 60 min before the tests. Two submaximal trials of IMTP were performed at increasing intensities for 5 seconds (approximately %40-60 and %60-80 of their individually perceived 1RM, respectively, with 60-second rest intervals).

Eligibility criteria: Inclusion Criteria:

* Being physically active and healthy
* Did not use ergogenic supplements in the last 3 months
* Did not consume high doses of caffeine (≤120-170 mg/d) were included in this study

Exclusion Criteria:

* Actively using supplements
* Did not perform maximal effort during performance tests
* Not using the supplements in the correct dose or vomiting after use

Primary outcomes:
measure: Isometric Mid-Thigh Pull (IMTP)
timeFrame: immediately after the intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Eskişehir
country: Turkey
facility: Faculty of Sport Sciences Eskisehir Technical University
state: Tepebasi
Study officials:
References:
Clinical trial NCT06205069: The Immediate Effects of Tissue Flossing on Knee Flexion Range of Motion
Official title: The Immediate Effects of Tissue Flossing on Knee Flexion Range of Motion: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: University Fernando Pessoa
Sponsor class: OTHER
First posted: 2024-01-12
Enrollment: 58
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study is to verify the immediate effects of Tissue Flossing on knee flexion range of motion

Detailed description: After completing the questionnaire, 58 healthy participants will be randomly divided into two groups named Intervention Group (IG) (n=29) and Control Group (CG) (n=29).

In the first assessment (M0), knee flexion ranges will be measured using a goniometer. Then the control group (n=29), without Tissue Flossing and intervention group (n=29) with Tissue Flossing around the knee joint will be subjected to passive and then active mobilization of the knee joint. Immediately after the intervention/control, the two groups will be assessed again (M1).

Eligibility criteria: Inclusion Criteria:

* healthy people between 18 and 35 years old with normal mobility of the joints of the lower limbs of the body.

Exclusion Criteria:

* deformities in the region of the lower limbs of the body, complaints in this region in the last 6 months, surgical procedures, venous thrombotic disease, heart disease, respiratory disease, or neurological, orthopedic, dermatitis, or neuromuscular problems in the lower quadrant that may disrupt musculoskeletal function. Also high blood pressure, latex allergies, lymphedema and individuals taking anticoagulant medication, and cortisteroid therapy.

Primary outcomes:
measure: Change of knee range of motion
timeFrame: [Time Frame: Change from Baseline (M0) to Immediately after intervention or control (M1)]
Secondary outcomes:
Other outcomes:
Locations:
city: Porto
country: Portugal
facility: Escola Superior Saúde Fernando Pessoa
Study officials:
References:
Clinical trial NCT04047069: The Effect of Occupational Therapy Intervention in Hemodialysis Patients
Official title: The Effect of Person-Centered Occupational Therapy Intervention on Occupational Performance and Quality of Life in Hemodialysis Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Quality of Life
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2019-08-06
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to investigate the effect of person-centre occupational therapy intervention on activity performance and quality of life in hemodialysis patients. The results of the study will guide the intervention programs for prevention, coping and improving the quality of life of HD patients.


Eligibility criteria: Inclusion Criteria:

* diagnosed as chronic renal failure.
* between 18-65 years
* undergoing HD treatment for at least 1 year

Exclusion Criteria:

* Beck Depression Scale score of 17 or higher

Primary outcomes:
measure: Quality of life (with a quality of life scale specific to renal patients).
timeFrame: 1st day of study
Secondary outcomes:
Other outcomes:
Locations:
city: Edirne
country: Turkey
facility: Özgü İnal
Study officials:
affiliation: Trakya University
name: Özgü İnal
role: PRINCIPAL_INVESTIGATOR
References: