Clinical trial NCT02177669: Test-Retest Variability of Quick Contrast Sensitivity Function Testing
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: Normal, healthy individuals without ocular disease
Ages 20-89
English speaking
Visual acuity better than 20/25
Lead sponsor: Nova Southeastern University
Sponsor class: OTHER
Collaborators: name: Adaptive Sensory Technology
First posted: 2014-06-30
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Maximum age (years): 89
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals between the ages of 20-89 without ocular disease will be recruited from among patients seen in the Primary Eye Care Clinic at the Nova Southeastern University's The Eye Care Institute in Davie-Ft. Lauderdale, FL, as well as faculty, students and staff at this institution.

Brief summary: The contrast sensitivity function (CSF) provides a comprehensive characterization of spatial vision and predicts functional vision better than visual acuity, but long testing times prevent its psychophysical assessment in clinical applications. Dr. Luis Lesmes et al. (2010) developed the qCSF method to obtain precise CSF measurements in only 30-50 trials using a computerized software program that presents letters on a large monitor that are identified by a patient similar to typical visual acuity testing with an eye chart. The quick CSF method is a Bayesian adaptive method that estimates the full shape of the CSF, and the test duration is only about 3-6 minutes. Some preliminary testing has been performed at other sites with this test in patients with vision loss due to amblyopia and glaucoma, but data from individuals without eye disease who have normal visual acuity has not been systematically collected with the latest version of this test procedure across a wide range of ages. In addition, we aim to gain a better understanding of the typical test-retest variability that is obtained between-sessions that are about a week apart from individuals with good ocular health and visual acuity.


Eligibility criteria: Inclusion Criteria:

* Ages 20-89
* Normal distance visual acuity in each of both eyes (20/20)
* Absence of ocular disease
* Able and willing to complete contrast sensitivity testing
* Provide informed consent

Exclusion Criteria:

* Any ocular disease
* Refractive errors \>6D
* Inability to understand study or communicate responses (cognitive impairment)
* Unable to understand, read and speak English fluently

Primary outcomes:
measure: 95% coefficient of repeatability across subjects
timeFrame: test-retest at 2 visits about a week apart
Secondary outcomes:
Other outcomes:
Locations:
city: Fort Lauderdale
country: United States
facility: Nova Southeastern University; College of Optometry
state: Florida
Study officials:
affiliation: Nova Southeastern University; College of Optometry
name: Ava K Bittner, OD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dorr M, Lesmes LA, Lu ZL, Bex PJ. Rapid and reliable assessment of the contrast sensitivity function on an iPad. Invest Ophthalmol Vis Sci. 2013 Nov 5;54(12):7266-73. doi: 10.1167/iovs.13-11743.
citation: Lesmes LA, Lu ZL, Baek J, Albright TD. Bayesian adaptive estimation of the contrast sensitivity function: the quick CSF method. J Vis. 2010 Mar 30;10(3):17.1-21. doi: 10.1167/10.3.17.