louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02455401: Effect of Remifentanil on Postoperative Vomiting in Pediatric Strabismus Surgery
Official title: Effect of Remifentanil on Postoperative Vomiting in Children Undergoing Strabismus Surgery During Sevoflurane Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Strabismus
Keywords: Postoperative Vomiting
Lead sponsor: Inje University
Sponsor class: OTHER
First posted: 2015-05-27
Enrollment: 60
Sex: ALL
Minimum age (years): 3
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to compare the effect of remifentanil on postoperative vomiting in children undergoing strabismus surgery during sevoflurane anesthesia.

Detailed description: Children undergoing strabismus surgery frequently experience postoperative vomiting (POV) that results in dehydration, aspiration pneumonia, bleeding, delayed hospital discharge, as well as decreased parental satisfaction and an unpleasant experience for the pediatric patients. Although administration of perioperative opioids increases POV incidence, remifentanil has less affect the incidence of POV than other opioids such as fentanyl. However, there are few study that evaluate the effects of remifentanil on the incidence of POV. Therefore, the investigators will conducted the study that the effects of remifentanil on the incidence of POV in children undergoing strabismus surgery during sevoflurane anesthesia. One hundred five children from 3 to 6 yr of age, ASA physical status 1 or 2 were assigned randomly selected to one of three groups: high dose remifentanil group (bolus 1.0 mcg/kg; infusion 0.1 mcg/kg/min), low remifentanil group (bolus 0.5 mcg/kg; infusion 0.1 mcg/kg/min), or no remifentanil group (no remifentanil administration). Primary endpoint, the incidence of POV for 24 hours postoperatively, will be compared between three study groups.

Eligibility criteria: Inclusion Criteria:

* children undergoing elective strabismus surgery under sevoflurane anesthesia

Exclusion Criteria:

* children who experienced postoperative retching or vomiting
* children who have taken anti-emetic medications within 24 hours before surgery
* children who experienced motion sickness

Primary outcomes:
measure: incidence of postoperative vomiting in PACU and surgical ward
timeFrame: from extubation to 24 hours
Secondary outcomes:
measure: postoperative pain in PACU and surgical ward
timeFrame: from extubation to 24 hours
measure: postoperative emergence agitation
timeFrame: from extubation to 24 hours
Other outcomes:
Locations:
city: Busan
country: Korea, Republic of
facility: Haeundae paik hospital, inje university
Study officials:
affiliation: Inje University
name: Lee, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04131101: Housing Conditions: Evaluation, Advocacy and Research in Toronto Community Housing
Official title: Housing Conditions: Evaluation, Advocacy and Research in Toronto Community Housing
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Housing
Keywords: Community organizing
Advocacy
Lead sponsor: Unity Health Toronto
Sponsor class: OTHER
First posted: 2019-10-18
Enrollment: 53
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This project will examine whether a health promotion campaign using community organizing and joint advocacy by a coalition of tenants, health providers, social service agencies and advocates can lead to improvements in building conditions and health in social housing.

Detailed description: This community based participatory research project will bring together patients of the St. Michael's Hospital Academic Family Health Team (FHT) who are tenants of Toronto Community Housing Corporation (TCHC) with health providers, legal service staff at the Health Justice Program, social service agencies and advocacy organizations to advocate to improve building conditions in three TCHC buildings. The researchers will evaluate the acceptability and feasibility of this health promotion campaign as well as changes in the state of housing and self rated physical and mental health of tenants.

Eligibility criteria: Inclusion Criteria:

* 18 years or older
* Living in one of the three TCHC buildings

Exclusion Criteria:

* under 18 years old

Primary outcomes:
measure: Tenant engagement in intervention
timeFrame: 12 months
measure: Building conditions
timeFrame: 12 months
measure: Health (Patient-Reported Outcomes Measurement Information System (PROMIS) scale)
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: St. Michael's Hospital
state: Ontario
Study officials:
affiliation: Unity Health Toronto
name: Andrew Pinto, MSc MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01233401: Tdap Vaccination for Infant Caregivers
Official title: Tdap Vaccination for Infant Caregivers in the Pediatric Office
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pertussis
Vaccination
Keywords: Pertussis, Vaccination, Adult
Lead sponsor: Yale University
Sponsor class: OTHER
Collaborators: name: Saint Raphael Healthcare System
First posted: 2010-11-03
Enrollment: 102
Sex: ALL
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 18-64 year old men and women who are mothers or other infant caregivers of 2 week old infants

Brief summary: This study evaluates whether offering Tetanus, diphteria and acellular pertussis (Tdap) vaccine to caregivers of newborn infants during pediatric well child visits increase the caregivers' vaccination rates.


Eligibility criteria: Inclusion Criteria:

* 18-64 years old
* English or Spanish speaking

Exclusion Criteria:

* Do not speak English or Spanish

Primary outcomes:
measure: Maternal Tdap Vaccination Rate
timeFrame: At 2 week well child visit
Secondary outcomes:
measure: Other Infant Caregiver Tdap Vaccination Rate
timeFrame: At 2 week well child visit
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Hospital of St. Raphael
state: Connecticut
Study officials:
affiliation: Yale University
name: Deepa R Camenga, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Yale University
name: Marjorie Rosenthal, MD MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06564701: A Pediatric Comparison of Remote Microphone Technologies
Official title: A Pediatric Comparison of Remote Microphone Technologies
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hearing Loss
Lead sponsor: Sonova AG
Sponsor class: INDUSTRY
Collaborators: name: Hearts for Hearing
First posted: 2024-08-21
Enrollment: 25
Sex: ALL
Minimum age (years): 8
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Speech intelligibility testing will be conducted on a single group of participants, first using one remote mic system, and then the other. The order of devices will be counter-balanced across participants.
Primary purpose: TREATMENT

Brief summary: Speech intelligibility will be evaluated for school age children with hearing loss in a simulated classroom environment, using Phonak hearing aids and receivers and two different microphone transmitters: a Roger Touchscreen mic and a fixed directional microphone.

Detailed description: Speech intelligibility will be evaluated for school age children with hearing loss in a simulated classroom environment, using Phonak hearing aids and receivers and two different microphone transmitters: a Roger Touchscreen mic and a fixed directional microphone. The simulated classroom environment will include a teacher condition, in which speech is presented from a distance in front of the participant, and a small-group condition, in which speech is presented randomly from three different speakers around the participant. Both conditions will have diffuse background noise, and the various SNR (Signal to Noise Ratio) levels will be tested.

Subjective preference and fatigue questionnaires will also be collected from the participants after the use of each transmitter.

Eligibility criteria: Inclusion Criteria:

* Healthy middle and outer ear
* Mild, moderate or moderate-severe binaural sensorineural hearing loss
* Minimum AZ Bio score of 70% at 60 dB in quiet
* Experienced hearing aid users (6+ months)
* Able to read and follow directions
* English speakers with ability to communicate easily

Exclusion Criteria:

* Active middle ear infection
* Temporary or unilateral hearing loss
* Unable to follow verbal directions
* Unable to communicate easily
* Unable to tolerate the physical fit of the hearing aids

Primary outcomes:
measure: Speech Intelligibility score using the AZ Bio Sentence Test-teacher condition
timeFrame: One day (Visit 1)
measure: Speech Intelligibility score using the AZ Bio Sentence Test- small group condition
timeFrame: One day (Visit 1)
Secondary outcomes:
measure: Listening Fatigue using the Vanderbilt Fatigue Scale for Children
timeFrame: Two days (Visit 2 and Visit 3)
measure: Subjective Preferences of participants
timeFrame: Two days (Visit 1 following the lab testing, and Visit 3, following the field trial)
Other outcomes:
Locations:
city: Oklahoma City
country: United States
facility: Hearts for Hearing
state: Oklahoma
Study officials:
References:
Clinical trial NCT03384901: The Results of Pars Plana Vitrectomy in Diabetic Macular Edema
Official title: The Results of Pars Plana Vitrectomy in Diabetic Macular Edema
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Diabetic Macular Edema
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2017-12-28
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients attending the Hillel Yaffe Medical Center Ophthalmology Clinic

Brief summary: This study will be a retrospective analysis of vitrectomy results in patients suffering from diabetic macular edema.


Eligibility criteria: Inclusion Criteria:

* Diabetic macular edema patients after vitrectomy

Exclusion Criteria:

* All others

Primary outcomes:
measure: Visual acuity
timeFrame: 6 months
Secondary outcomes:
measure: Macular thickness
timeFrame: 6 months
Other outcomes:
Locations:
city: Hadera
country: Israel
facility: Hille Yaffe Medical Center
Study officials:
References:
Clinical trial NCT01025401: Characterization of Epileptic Motor Patterns by Tridimensional Analysis of Movement 2
Official title: Caractérisation et détection Des Mouvements Durant Les Crises d'épilepsie à Des Fins d'Alarme, Pour un Usage en Institution et en Famille.
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Epileptic Patients With Motor Manifestations During Seizures
Keywords: epilepsy
seizures
movement
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2009-12-03
Enrollment: 50
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: CAPAMETRIM 2 aims to characterize epileptic motor patterns by a quantitative three-dimensional analysis of movements.

This is done to obtain a 3-D motor signature of seizures, for a given patient, and allows their detection with an ambulatory monitoring system.

The benefit for patients is to improve the diagnosis of their diseases by better characterizing their seizures.

Detailed description: CAPAMETRIM 2 aims to characterize epileptic motor patterns by a quantitative three-dimensional analysis of movements.

The project is planned in three phases:

* Installation of 3-D accelerometric and magnetic sensors acquisition systems on the hospital (extension of a preceding study CAPAMETRIM).
* Collection of data on epileptic patients. Sensors will be positioned on the right and left hands and on the head. A 3-D analysis of movements will be done according to the collection by tagging data with visual analysis made on video.
* Development of a motor pattern classification system used for seizure detection.

Eligibility criteria: Inclusion Criteria:

* Adult or children (\>= 6 years)
* Written inform consented from the patient or its legal representative
* Presurgical investigation of pharmaco-resistant partial epilepsy
* Motor manifestations during seizures

Exclusion Criteria:

* Proved generalized epilepsy
* No motor manifestations during seizures
* Pregnant women
* Subjects deprived of freedom by an administrative or judicial decision

Primary outcomes:
measure: 3-D accelerometric and magnetic sensors
timeFrame: continuously during hospitalization recordings (46 Hz from 9 h to 17 h)
Secondary outcomes:
measure: Video
timeFrame: continuously during hospitalization recordings (25 fps from 9 h to 17 h)
measure: EEG
timeFrame: continuously during hospitalization recordings (256-1024 Hz from 9 h to 17 h)
Other outcomes:
Locations:
city: Grenoble
country: France
facility: Grenoble University Hospital Epilepsy Monitoring Unit
Study officials:
affiliation: University Hospital, Grenoble
name: Philippe Kahane, MD PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06772701: Validation of the French Version of the Edinburgh Postnatal Depression Scale (EPDS) Postnatally in the Father
Official title: Validation of the French Version of the Edinburgh Postnatal Depression Scale (EPDS) Postnatally in the Father
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Depression, Postpartum
Lead sponsor: Groupe Hospitalier du Havre
Sponsor class: OTHER
First posted: 2025-01-13
Enrollment: 1000
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Fathers included at the maternity hospital or through the mother take the Mini International Neuropsychiatric Interview and complete the PH-Q9, EPDS and socio-demographic questionnaires. Fathers included through the awareness campaign have only the PH-Q9, EPDS and socio-demographic questionnaires.
Primary purpose: SCREENING

Brief summary: In recent years, fatherhood has changed considerably. Fathers are now more involved during the perinatal period, with their partner but also in caring for the child. We now know that this period is also a source of major psychological upheaval, identity crisis, apprehension and anxiety for men. These upheavals can lead to depression that must be detected and treated as early as possible. This is an easy screening to perform using the EPDS (Edinburgh Postnatal Depression Scale). Currently, the EPDS is the most widely used self-questionnaire to assess the risk of depression in women during the perinatal period. Indeed, it is systematically recommended in many countries. It is starting to be used for the same purpose in the perinatal period in men, although the scale has not been validated in a representative sample of men in the pre- or post-natal period.

The main objective is to validate the use of the EPDS scale as a screening tool for postnatal depression in a population of French fathers.

They complete the PH-Q9, EPDS and socio-demographic questionnaires online at inclusion and 6 to 8 weeks after the birth of their child. Fathers included at the maternity ward also too Mini International Neuropsychiatric Interview (MINI) at inclusion.


Eligibility criteria: Inclusion Criteria:

* All fathers whose baby is 10 days old or less

Exclusion Criteria:

* People with a poor understanding of spoken or written French
* Minors
* Persons under court protection, guardianship or curatorship

Primary outcomes:
measure: Mini International Neuropsychiatric Interview
timeFrame: at inclusion
Secondary outcomes:
measure: socio-demographic questionnaire
timeFrame: at inclusion and 6 to 8 weeks after the birth of their child
Other outcomes:
Locations:
city: Clamart
country: France
facility: Antoine-Béclère hospital AP-HP
city: Montivilliers
country: France
facility: Le Havre hospital - site Jacques Monod
Study officials:
References:
Clinical trial NCT02351401: Rheumatoid Arthritis Through Education and US Study (RAEUS)
Official title: Improvement in Patient Awareness and Ability to Assess Disease in Rheumatoid Arthritis: Rheumatoid Arthritis Through Education and US Study (RAEUS)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Rheumatoid Arthritis
Lead sponsor: National University Hospital, Singapore
Sponsor class: OTHER
First posted: 2015-01-30
Enrollment: 101
Sex: ALL
Minimum age (years): 21
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Patients can potentially monitor disease activity of rheumatoid arthritis (RA) through self-assessed swollen joints (clinical synovitis)joint counts but reliability of joint swelling is poor. The objective is to evaluate the use of education by ultrasound feedback on the ability of patients to assess for clinical synovitis swollen joints in RA.

Detailed description: Design: 6-month single centre randomized controlled trial. Patients: established RA. Intervention: education on self-assessment of joints that included initial brief patient training on tender (TJC) and swollen (SJC) joint counts, followed by US feedback every 3 months versus standard care without education. Patient and physician independently performed 28-joint counts at each visit. Outcome variables: (Primary) Percentage of patients with good agreement with physician derived swollen joints (prevalence-adjusted bias adjusted kappa, PABAK\>0.6). Other variables: Agreement in SJC (Bland and Altman 95% limits of agreement), feasibility/patient satisfaction survey and disease activity score (DAS28) at 6 months.

Eligibility criteria: Inclusion Criteria:

* RA patients fulfilling ACR1987 criteria
* adults between age 21 and 80 years

Exclusion Criteria:

* pregnant
* no mental health illness
* fit to perform informed consent

Primary outcomes:
measure: prevalence-adjusted bias adjusted kappa, PABAK>0.6
timeFrame: at 6 months
Secondary outcomes:
measure: Bland and Altman 95% limits of agreement
timeFrame: 6 months
measure: Level of satisfaction
timeFrame: 6 months
measure: disease activity score in 28 joints (DAS28)
timeFrame: 6 months
Other outcomes:
Locations:
Study officials:
affiliation: National University Hospital, Rheumatology
name: Peter Cheung
role: PRINCIPAL_INVESTIGATOR
References:
citation: Cheung PP, Lahiri M, Teng GG, Lim AY, Lau TC, Lateef A, Mak A, Gossec L, March L. A randomized controlled trial for improving patient self-assessment of synovitis in rheumatoid arthritis with education by ultrasonography: the RAEUS Study. Rheumatology (Oxford). 2015 Jul;54(7):1161-9. doi: 10.1093/rheumatology/keu447. Epub 2014 Dec 3.
Clinical trial NCT06958601: Safety and Efficacy of Transoral Robotic Thyroidectomy Versus Traditional Open Thyroidectomy for Thyroid Cancer
Official title: Comparative Analysis of the Safety and Efficacy of Transoral Robotic Thyroidectomy Versus Conventional Open Thyroidectomy
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Thyroid Cancers
Lead sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Sponsor class: OTHER
First posted: 2025-05-06
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Thyroid cancer patients

Brief summary: In general, the utilization of the transoral vestibular approach in robotic surgery demonstrates efficacy comparable to that of traditional open surgery in the treatment of thyroid cancer. This method not only reduces the length of hospitalization for patients but also ensures superior cosmetic outcomes in the cervical region, thus achieving truly scarless aesthetics. The feasibility of Transoral Vestibular Robotic Thyroidectomy (TOVRT) for tumors greater than 2 cm in diameter warrants further exploration in future studies; however, for tumors less than 2 cm in diameter, TOVRT emerges as a safe, reliable, and practical alternative, poised to establish itself as an innovative surgical modality.


Eligibility criteria: Inclusion Criteria:

* Age 18- 65 years old, both male and female
* Postoperative pathology was papillary thyroid carcinoma
* Clinical data integrity

Exclusion Criteria:

* Postoperative pathology was benign
* Clinical data are incomplete

Primary outcomes:
measure: Key Observational Indicators
timeFrame: 6moths
Secondary outcomes:
measure: Secondary observations
timeFrame: 6months
Other outcomes:
measure: Other Pre-Specified Outcome
timeFrame: 6moths
Locations:
Study officials:
References:
Clinical trial NCT02205801: Study of the Efficacy of Local Analgesia as an Adjunct to General Anesthesia in Thyroidectomy and Parathyroidectomy
Official title: A Randomized Control Trial Comparing Bilateral Superficial Cervical Plexus Block and Local Wound Infiltration in Thyroidectomy and Parathyroidectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Thyroid Neoplasms
Goiter, Nodular
Thyroid Nodule
Graves' Disease
Hyperparathyroidism
Lead sponsor: University of Chicago
Sponsor class: OTHER
First posted: 2014-07-31
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: We aim to study the effect of local anesthetic when used in conjunction with general anesthesia during thyroidectomy or parathyroidectomy. We hypothesize there is equivalent pain control between bilateral superficial cervical plexus block and local wound infiltration when used in conjunction with a general anesthetic.


Eligibility criteria: Inclusion Criteria:

* Patient ≥ 18 years old
* Surgical indication for parathyroidectomy or thyroidectomy

Exclusion Criteria:

* Patients \< 18 years old
* Patient with history of chronic opioid use
* Patient with chronic pain syndromes
* Patient with allergy to marcaine

Primary outcomes:
measure: Intraoperative Fentanyl Administration
timeFrame: During the procedure
Secondary outcomes:
measure: Post Operative Pain
timeFrame: At four hour after operation
measure: Post Operative Nausea Score
timeFrame: At 2 weeks after operation
measure: Total Pain Medication Utilization
timeFrame: At follow up appointment 1-2 weeks postoperatively
Other outcomes:
Locations:
city: Chicago
country: United States
facility: University of Chicago Medical Center
state: Illinois
Study officials:
affiliation: University of Chicago
name: Raymon Grogan, MD
role: PRINCIPAL_INVESTIGATOR
References: