louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04859192: Gamified Flipped Class Room and Nursing Students' Skills Competency and Confidence
Official title: Effect of Gamified Flipped Class Room on Facilitating Nursing Students' Skills Competency and Confidence
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Gamified Flipped Classroom
Education, Nursing Students
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2021-04-26
Enrollment: 128
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: one of the primary components of effective teaching is student engagement and that engagement is critical for learning

Detailed description: In order to increase motivation, it is necessary to eliminate the factors that create boredom and to transform the lectures into a more enjoyable environment. In recent years, the gamification strategy has been used in order to intrigue the students, and to increase their motivation for learning. Gamification is a system that implements game design components on out-of-game contexts and alters the subjects' behaviors.

Eligibility criteria: Inclusion Criteria:

* agree to participate.
* Registered fundamental II in second semester year (2020-2021).
* Have access to network at home.

Exclusion Criteria:

* • Previously enrolled in fundamental II course

Primary outcomes:
measure: changes in students learning motivation score
timeFrame: will be measured at baseline and at the end of study (after 6 weeks)
measure: change in skill practice confidence level
timeFrame: will be measured at baseline and at the end of study (after 6 weeks)
measure: change in nursing students funadamental skill competency
timeFrame: will be measured at baseline and at the end of study (after 6 weeks)
measure: changes in students fundamental of nursing knowledge level
timeFrame: at baseline and three weeks and 6 weeks of study
Secondary outcomes:
measure: intensity of nursing skills preparation
timeFrame: will be measured at baseline and at the end of study (after 6 weeks)
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Faculty of Nursing Mansoura University
Study officials:
References:
citation: Elzeky MEH, Elhabashy HMM, Ali WGM, Allam SME. Effect of gamified flipped classroom on improving nursing students' skills competency and learning motivation: a randomized controlled trial. BMC Nurs. 2022 Nov 16;21(1):316. doi: 10.1186/s12912-022-01096-6.
Clinical trial NCT06779292: Application of Large Language Models in Emergency Neurology
Official title: Application of Multimodal Large Language Models in Emergency Neurology Diagnosis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neurology
Emergency
Lead sponsor: Capital Medical University
Sponsor class: OTHER
First posted: 2025-01-16
Enrollment: 433
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients in the emergency neurology department

Brief summary: Emergency neurology covers a wide range of conditions, often involving urgent situations such as acute cerebrovascular diseases, seizures, central nervous system infections, and consciousness disorders. However, due to the time constraints in emergency care and limited patient information collection, misdiagnosis and missed diagnoses are common issues. Large language models (LLMs) possess powerful natural language processing and knowledge reasoning capabilities, enabling them to directly handle and understand complex, unstructured medical data such as patient medical records, dialogue notes, and laboratory test results. LLMs show broad potential for application in complex medical scenarios. This study aims to evaluate the application value of LLMs in emergency neurology, specifically examining their diagnostic accuracy in emergency neurology conditions, analyzing the feasibility of treatment plans and further examination recommendations proposed by the model, and exploring their potential in improving diagnostic efficiency and aiding decision-making.


Eligibility criteria: Inclusion Criteria:

* Age ≥18-80 years, male or female.
* Patients seeking emergency neurology care.
* Patients who can provide complete medical records (including consultation recordings, physical examination, test results, etc.).
* Voluntary participation and signing of informed consent.

Exclusion Criteria:

* Patients who directly enter the resuscitation process due to the severity of their condition(e.g., patients who are immediately placed in the ICU).
* Patients with unstable vital signs.
* Patients who are unable to communicate effectively (e.g., severe consciousness impairment or severe cognitive disorders).
* Patients who are currently participating in other clinical trials.

Primary outcomes:
measure: dignostic accuracy
timeFrame: 1 month
Secondary outcomes:
measure: Feasibility of treatment plans
timeFrame: 1 month
measure: dignostic specificity
timeFrame: 1 month
measure: Diagnostic Sensitivity
timeFrame: 1 month
measure: False Discovery Rate
timeFrame: 1 month
Other outcomes:
Locations:
city: Beijing
country: China
facility: Xuanwu Hospital, Capital Medical University
state: Beijing
Study officials:
References:
Clinical trial NCT03912792: A Cross-Sectional Natural History Study to Evaluate Sweat Volume and Other Phenotypic and Genetic Characteristics in Patients Affected by XLHED
Official title: A Cross-Sectional Natural History Study to Evaluate Sweat Volume and Other Phenotypic and Genetic Characteristics in Patients Affected by X-Linked Hypohidrotic XLHED Ectodermal Dysplasia (XLHED)
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: XLHED
Keywords: Natural History Study
X-Linked Hypohidrotic Ectodermal Dysplasia
Lead sponsor: Dermelix Biotherapeutics, LLC.
Sponsor class: INDUSTRY
First posted: 2019-04-11
Enrollment: 0
Sex: ALL
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Males with XLHED and female carriers of XLHED

Male and female healthy volunteers

Brief summary: The proposed natural history study will enroll male patients with a diagnosis of XLHED, female carriers of XLHED and healthy volunteers. The study protocol will include collection of XLHED questionnaires and clinical outcomes using minimally invasive technologies. Data will be collected both retrospectively and prospectively.

Clinical outcome assessments will be performed at the NFED Family Conference on July 11-12, 2019. Study participants will be able to complete XLHED questionnaires electronically ahead of the conference.


Eligibility criteria: Inclusion Criteria:

* Informed Consent
* Males with XLHED, female carriers of XLHED and healthy volunteers

Exclusion Criteria:

* Treatment with an investigational study drug for XLHED
* Any major medical problems that would prevent her/him from participating in this study
* Known hypersensitivity to pilocarpine or pilocarpine-like muscarinic agonists (Examples: Urecholine, Salagen, Pilocar, and Provocholine)
* Pacemaker

Primary outcomes:
measure: The volume of sweat from a pilocarpine-induced sweat test
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Lincolnshire
country: United States
facility: Chicago Marriott Lincolnshire Resort
state: Illinois
Study officials:
affiliation: Washington University School of Medicine
name: Dorothy K Grange, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04352192: Effect of Kinesiotaping on Muscle Activity
Official title: The Effect of Kinesiotaping on Bioelectrical Muscle Activity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: kinesiotaping
EMG
Lead sponsor: Bezmialem Vakif University
Sponsor class: OTHER
Collaborators: name: Istanbul University - Cerrahpasa
First posted: 2020-04-20
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The aim of the investigator's study is to analyze the effect of kinesiotaping (KT) on the electrical activity of the muscle by using time and frequency domain analysis of the electromyography (EMG) signals.

Detailed description: The kinesiotaping (KT) is a taping technique that is commonly used to improve muscle performance and facilitate or inhibit muscle activity in rehabilitation. A study reported that KT application did not change electrical activity in the early period (immediately after KT, 5th and 10 minutes after KT). However, another study showed that EMG activity increased 24 hours after KT application. A study revealed that the KT produced more EMG activity compare to placebo taping. In conclusion, the effect of KT on electrical muscular activity was arguable in the literature.

Eligibility criteria: Inclusion Criteria:

* To be right-handed-dominant
* To have normal or corrected vision
* To have no formal history of any resistance training.

Exclusion Criteria:

* To have history of neurological or recent musculoskeletal injury

Primary outcomes:
measure: The first assessment of electromyographic activity
timeFrame: at inclusion
measure: The second assessment of electromyographic activity
timeFrame: after KT application for KT group or at 10th minutes after the first assessment
measure: The third assessment of electromyographic activity
timeFrame: 30 minutes after the second assessment
measure: The last assessment of electromyographic activity
timeFrame: at 24 hours after KT application or the second assessment
Secondary outcomes:
measure: The first assessment of maximum isometric voluntary contraction torque
timeFrame: at inclusion
measure: The second assessment of maximum isometric voluntary contraction torque
timeFrame: after KT application for KT group or at 10th minutes after the first assessment
measure: The third assessment of maximum isometric voluntary contraction torque
timeFrame: 30 minutes after the second assessment
measure: The last assessment of maximum isometric voluntary contraction torque
timeFrame: at 24 hours after KT application or the second assessment
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Bezmialem Vakıf University
Study officials:
affiliation: Bezmialem Vakif University
name: Hilal DENIZOGLU KULLI, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06326892: Natural Orifice Specimen Extraction in Low Rectal Cancer Surgery
Official title: Postoperative Outcomes of Natural Orifice Specimen Extraction (NOSE) in Low Rectal Cancer Surgery
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Rectal Cancer
Surgery
Keywords: Rectal Cancer
Natural Orifice Specimen Extraction
Propensity score matched
Lead sponsor: Istituto Clinico Humanitas
Sponsor class: OTHER
First posted: 2024-03-22
Enrollment: 350
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with low rectal cancer to the English National Low Rectal Cancer Development Programme (LOREC) who underwent low rectal resection with Total Mesorectal Excision (TME)

Brief summary: This study aims to compare the postoperative outcomes of low rectal cancer patients who underwent surgery with Natural Orifice Specimen Extraction (NOSE) versus traditional Pfannenstiel extraction.

Detailed description: Natural Orifice Specimen Extraction (NOSE) in colorectal surgery allows the extraction of the surgical specimen through the anal orifice. Several studies demonstrated improved postoperative pain, bowel movements, patient-reported cosmetic satisfaction, and psychological wellbeing after NOSE compared with traditional Pfannenstiel extraction. However, most of these studies focused on colon surgery. The aim of this retrospective propensity score matched study is to investigate the postoperative outcomes of NOSE in low rectal cancer surgery, classified according to the English National Low Rectal Cancer Development Programme (LOREC).

Eligibility criteria: Inclusion Criteria:

* Patients undergoing low anterior resection with Total Mesorectal Excision (TME) for low rectal cancer between January 2017 and January 2023
* Patients with rectal cancer classified as "low" according to the English National Low Rectal Cancer Development Programme (LOREC)

Exclusion Criteria:

* Patients undergoing non-restorative procedures
* Patients undergoing immediate or delayed handsewn coloanal anastomosis
* Patients undergoing planned open surgery or unplanned conversion from minimally invasive to open surgery
* Patients with a concomitant diagnosis of Inflammatory Bowel Disease (IBD)

Primary outcomes:
measure: Surgical Site Infections (SSI)
timeFrame: 30 days after surgery
Secondary outcomes:
measure: Opioid rescue
timeFrame: From the date of surgery to the date of discharge
measure: Postoperative pain
timeFrame: 72 hours after surgery
measure: Postoperative ileus
timeFrame: 30 days after surgery
measure: Incisional hernia
timeFrame: 6 months after surgery
measure: Overall postoperative complications
timeFrame: 30 days after surgery
Other outcomes:
Locations:
city: Rozzano
country: Italy
facility: IRCCS Humanitas Research Hospital
state: MI
Study officials:
affiliation: IRCCS Huamanitas Research Hospital
name: Antonino Spinelli, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05436392: De-adopting Routine Preoperative Benzodiazepines for Older Surgical Patients
Official title: DROP-Benzo (De-adopting Routine Preoperative Benzodiazepines for Older Surgical Patients): a Randomized Trial of Behavioral Strategies to Reduce Unnecessary Midazolam Administration to Older Surgical Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Surgery
Aging
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
Collaborators: name: US Anesthesia Partners
name: Donaghue Medical Research Foundation
First posted: 2022-06-29
Enrollment: 517611
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Over 21 million surgical procedures take place among adults aged 65 and older in the US each year, and most older surgical patients in the US now receive benzodiazepines (e.g., midazolam, lorazepam) during anesthesia care. This occurs despite recommendations to avoid these medications in older patients due to associated medical risks and lack of demonstrated benefit. In other words, routine benzodiazepine administration to older surgical patients is likely to represent low-value care that is a suitable target for de-adoption. In this study, we will evaluate a United States Anesthesia Partners (USAP, Dallas, TX) quality improvement initiative using peer comparison feedback to clinicians and/or mailed informational letters to patients as strategies to encourage physician de-adoption of routine preoperative benzodiazepine administration to older surgical patients. In partnership with USAP, this study will be conducted using randomization to evaluate its effect.


Eligibility criteria: Inclusion Criteria:

* All anesthesia clinicians employed by USAP will be included in the evaluation. Patients will be included if they are at least aged 65 and undergo an elective (scheduled) surgical or endoscopic procedure under general anesthesia.

Exclusion Criteria:

* Patients will be excluded if they are unscheduled (urgent/emergent) cases due to inability to reliably deliver study interventions to this group; if they did not receive general anesthesia; or if they received a nerve block procedure.

Primary outcomes:
measure: Benzodiazepine administration rate
timeFrame: Intraoperative period
Secondary outcomes:
measure: Patient satisfaction
timeFrame: Up to 30 days after surgery
Other outcomes:
measure: Hospital length of stay
timeFrame: Length of stay will be evaluated at approximately 30 days after surgery
measure: Postoperative pulmonary complications
timeFrame: Up to 30 days after surgery
measure: Postoperative Delirium
timeFrame: Up to 30 days after surgery
Locations:
city: Dallas
country: United States
facility: US Anesthesia Partners
state: Texas
Study officials:
affiliation: University of Pennsylvania
name: Mark D Neuman, MD, MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04730492: HErnias REparation After Kidney Transplantation Study
Official title: A Retrospective Observational Study of Hernias Reparation in Patients Who Have Received a Kidney Transplant
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Prosthesis User
Renal Transplantation
Keywords: renal transplantation
post incision hernia
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2021-01-29
Enrollment: 83
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who have received renal transplantation with post-incisionale hernia

Brief summary: Correlation between hernias reparation in patients who have received a kidney transplant. The investigators will analyze the data of patients who have been treated for reparation of incisional hernia after kidney transplantation with or without the placement of a prosthesis.

Detailed description: In the scientific literature, the percentage of post incisional hernia in kidney transplanted patients is very variable, and not too well-argued, especially in the context of prevention and individuation of risk factors.

The increase of surgical management of hernias reparation in renal transplant patients justifies the start of a mon-centric type study. The investigators will look for risk factors with a retrospective, observational study, by analyzing the type of surgical repair of their post-surgical wall defect.

The analysis of costs/benefits on postoperative, intraoperative, or preoperative prevention will be taken into account.

Eligibility criteria: Inclusion criteria:

- hernia post renal transplantation

Exclusion criteria:

- underage

Primary outcomes:
measure: disembowelment number in FIG / D
timeFrame: 1 day
Secondary outcomes:
measure: type of wall closure technique in the context of a kidney transplant
timeFrame: 1 day
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uh Montpellier
Study officials:
affiliation: UH MONTPELLIER
name: Fabrizio PANARO, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT02078492: A Prospective Randomized Double-Blind Trial Comparing 3 Doses of Intravenous Ketorolac for Pain Management
Official title: A Prospective Randomized Double-Blind Trial Comparing 3 Doses of Intravenous Ketorolac for Pain Management in the Emergency Department"
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Pain
Lead sponsor: Maimonides Medical Center
Sponsor class: OTHER
First posted: 2014-03-05
Enrollment: 240
Sex: ALL
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Hypothesis: Intravenous administration of Ketorolac in a dose of 10 mg is as effective in treating severe acute pain in patients presenting to the ED as 15 mg and 30 mg.

Detailed description: Ketorolac tromethamine is a non-steroidal anti-inflammatory drug (NSAID) that is widely used in the Emergency Department (ED) for the treatment of moderate-to-severe pain. Ketorolac is available in both oral and parenteral forms and possess significant analgesic potency. However, ketorolac provides few advantages over other currently available analgesics and its use is limited by a virtue of having an "analgesic ceiling" with the dose being 10mg as well as having a range of severe side effects, of which gastrointestinal hemorrhage is most concerning.The concept of an analgesic ceiling is that doses beyond this value (10mg) do not provide additional analgesia and do contribute to side effects. In spite of this, the majority of research conducted on ketorolac in the ED and recommendations in Tintinalli's Emergency Medicine Textbook advocating for use of three-to-six fold higher dosages.

Hypothesis: Intravenous administration of Ketorolac in a dose of 10 mg is as effective in treating severe acute pain in patients presenting to the ED as 15 mg and 30 mg.

Eligibility criteria: Inclusion Criteria:

Severe flank and abdominal pain, severe musculoskeletal pain (traumatic and non-traumatic in origin), headache, dental pain.

Exclusion Criteria:

Age \>65, Active Peptic Ulcer disease, Acute Gastrointestinal Hemorrhage, Known Hx of Renal or Hepatic insufficiency, Hx of allergies to NSAIDS.

Primary outcomes:
measure: Pain Score at 30 Minutes
timeFrame: 30 minutes
Secondary outcomes:
measure: Adverse Effect of Dizziness
timeFrame: 120 minutes
measure: Adverse Effect of Nausea
timeFrame: 120 minutes
measure: Adverse Effect of Headache
timeFrame: 120 minutes
Other outcomes:
Locations:
city: Brooklyn
country: United States
facility: Maimonides Medical Center
state: New York
Study officials:
affiliation: Attending
name: Sergey Motov, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Catapano MS. The analgesic efficacy of ketorolac for acute pain. J Emerg Med. 1996 Jan-Feb;14(1):67-75. doi: 10.1016/0736-4679(95)02052-7.