louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02786433: Virtual Reality Effects on Functional Capacity and Quality of Life of People With Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson Disease
Lead sponsor: Universidade Federal de Pernambuco
Sponsor class: OTHER
First posted: 2016-06-01
Enrollment: 20
Sex: ALL
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disorder of dopaminergic neurons that can cause some mobility limitations and it has association with quality of life (QOL) in patients with PD. Virtual reality (VR) has been used to treat of these patients Objective: Evaluate the functional capacity and QOL of individuals with PD using VR with X-Box Kinect®. Methods: Were selected 20 individuals classified as stages 1-3, aged 50-75 years. They were divided by lot into two groups (control and experimental) with ten patients in each. The group (CG) treated with exercises (conventional therapy) during five-week, with two sessions per week lasting 60 minutes, while the experimental group (EG) spent half the time with conventional physical therapy and other half of time in virtual rehabilitation (VR). Subjects were evaluated before and after treatment using the following scales: Unified Parkinson's Disease Rating Scale and Parkinson's Disease Questionnaire .


Eligibility criteria: Inclusion Criteria:

* Patients with clinical diagnosis of idiopathic Parkinson's disease
* Male and female
* Stage 1-3 of the Hoehn and Yahr scale.

Exclusion Criteria:

* Have other neurological diseases
* They have decompensated systemic diseases
* Musculoskeletal changes that prevent the achievement of movements
* With lowering of the cognitive level assessed using the MiniMental State examination with cutoff point according to education
* With respiratory impairment
* With medical restrictions for performing exercises
* In physical therapy, occupational therapy service for 3 months or more;

Primary outcomes:
measure: Unified Parkinson's Disease Rating Scale - Evaluates disease progression
timeFrame: 8 weeks
measure: Parkinson's Disease Questionnaire (PDQ-39) - evaluates quality of life
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Recife
country: Brazil
facility: Pernambuco Parkinson Association
state: Pernambuco
Study officials:
References:
Clinical trial NCT04455087: Analysis of Complementary Exams Prescriptions From an Emergency Unit of a University Hospital
Official title: Complementary Exams in Emergency Department
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Complementary Investigations
Keywords: complementary exam
Lead sponsor: University of Monastir
Sponsor class: OTHER
First posted: 2020-07-02
Enrollment: 2000
Sex: ALL
Minimum age (years): 1
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: all patients consulting urences of Monastir aged more than 1 year

Brief summary: The objective of this study is to evaluate the appropriateness of prescribing additional tests in the emergency unit of the University Hospital of Monastir.

Detailed description: The objective of this study is to evaluate the appropriateness of prescribing additional tests in the emergency unit of the University Hospital of Monastir.

Eligibility criteria: Inclusion Criteria:

* all patients consulting Emergency Department of Monastir aged more than 1 year

Exclusion Criteria:

* age \< 1 year

Primary outcomes:
measure: The analysis focused on the appropriateness or otherwise of the complementary exams
timeFrame: The analysis focused on the appropriateness or otherwise of the complementary exams
Secondary outcomes:
Other outcomes:
Locations:
city: Monastir
country: Tunisia
facility: Hospital of Fattouma Bourguiba
Study officials:
affiliation: Netherlands: Ministry of Health, Welfare and Sports
name: semir nouira, phd
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06882187: ALI in Cancer Patients
Official title: Outcomes of Acute Limb Ischemia in Cancer Patients .
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Acute Limb Ischemia
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-03-18
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Cancer patients .

Brief summary: The aim of the study is to describe and evaluate the outcomes of cancer patients presenting with and treated for ALI at our center .

Detailed description: Acute limb ischemia (ALI) is a vascular emergency and is associated with significant morbidity and mortality. Peripheral arterial embolism or thrombosis from malignant disease is uncommon and a rare cause of acute limb ischemia. Limb ischemia can be caused by emboli from the tumor itself, from metastatic deposits within large vessels, as well as the tumors of adjacent organs such as the lung, which invade the left or right atrium of the heart and then disseminate to the main arteries of the body. This acute event may be the first indication of malignant disease in the patient.

Eligibility criteria: Inclusion Criteria:

* All cancer patient presented to Vascular and Endovascular surgery departement with ALI.

Exclusion Criteria:

* Patients with benign tumors or without active malignancy.
* Patients with iatrogenic limb ischemia related to a tumor chemoembolization procedure.

Primary outcomes:
measure: Limb Salvage
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00659087: Effectiveness of a Femoral Block Following Total Knee Arthroplasty (TKA)
Official title: A Pilot Study of the Feasibility of Early Discharge After Total Knee Arthroplasty Using a Femoral Nerve Block
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Total Knee Arthroplasty
Keywords: Total Knee
Range of Motion
Pain
Lead sponsor: Edmonton Civic Employees Research Fund
Sponsor class: OTHER
First posted: 2008-04-16
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Hospital stays after total joint replacement surgery have been getting shorter over the past 10 years. This is mostly due to new ways to manage pain and early rehabilitation. To be able to go home safely soon after surgery, patients need to:

* 1) have adequate pain control
* 2) be able to move through activities of daily living on their own (using aids)

Femoral nerve block, in combination with pain medications, is one of the new treatment strategies that are currently being used at other hospitals in Canada, the United States and the United Kingdom. Nerve blocks involve a needle filled with local anesthetic into the nerve that allows the feeling of pain around the knee. With good pain management, patients will be able to more quickly bend their knee and regain the ability to walk with aids and move from sitting and lying positions to standing and walking. Once they can do these activities with adequate pain control, they can be discharged from hospital to continue recovery at home. The purpose of this study is to examine a new way of managing postoperative pain and encourage early knee flexion and mobility, while maintaining pain control for patients after total knee replacement. We believe that patients who receive the nerve block in addition to the regular pain medication will have more knee flexion at discharge and experience less pain than patients who only receive usual pain medications.


Eligibility criteria: Inclusion Criteria:

* Undergoing primary total knee arthroplasty
* English-speaking
* Preoperative knee ROM \> 90 degrees
* Body Mass Index \< 40

Exclusion Criteria:

* Regular preoperative opioid use
* Hepatic insufficiency
* Any contra-indications to receiving a femoral block

Primary outcomes:
measure: knee flexion
timeFrame: at hospital discharge or day 4 postoperatively, whichever is earlier
Secondary outcomes:
measure: pain
timeFrame: daily in hospital, 2 weeks, 6 weeks, 12 weeks
measure: length of hospital stay
timeFrame: during hospitalization
measure: nausea/vomiting
timeFrame: during hospitalization
measure: participation in rehabilitation
timeFrame: day of surgery
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: University of Alberta Hospitals
state: Alberta
Study officials:
References:
Clinical trial NCT04384887: "Investigation of the Relationship Between New Coronary Virus Disease (COVID-19) and Anxiety and Depressive Symptoms in Pregnant Women"
Official title: ''(COVID-19) and Anxiety and Depressive Symptoms in Pregnant Women"
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID
Anxiety
Depression, Postpartum
Lead sponsor: Kanuni Sultan Suleyman Training and Research Hospital
Sponsor class: OTHER
Collaborators: name: Ayşegül Bestel
name: İbrahim Polat
name: Merve Aldıkaçtıoğlu Talmaç
First posted: 2020-05-12
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Pregnant women with a positive covid -19 pcr test between the ages of 18 and 45 will be included in the study and beck and anxiety tests will be performed 3 months after birth.

Brief summary: In our study; Anxiety and depression levels, socio-demographic characteristics of the pregnant women who were admitted to our hospital between 25.04.2020-25.07.2020 and treated with the diagnosis of covid 19, and the change in anxiety and depression levelsWİTH Beck Depression and Anxiety Score after the disease regressed are planned.

(Beck depression scale contains 10 questions and a total of 1 to 100 points is obtained. High score indicates that depression and anxiety are high.) 0-16 points = mild depressive symptoms

17-29 points = moderate depressive symptoms

30-63 points = severe depressive symptoms

Detailed description: The sociodemographic data form prepared by the researchers will be filled out by interviewing the patients who are willing to participate in the study. In addition, Beck Depression Scale, Beck Anxiety Scale, State and Trait Anxiety Scale will be given by the participants themselves. When the patients come to their first control after discharge, the scales specified will be repeated.

Eligibility criteria: Inclusion Criteria:

* covid -19 pcr positive pregnant women
* no psychiatric diagnosis no use of psychiatric medicine

Exclusion Criteria:

Non-pregnant patients, A psychiatric diagnosis use of psychiatric medicine

Primary outcomes:
measure: Evaluation of depression and anxiety score changes of covid-19 positive pregnants
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Pinar Yalcin Bahat
state: İ̇stanbul
Study officials:
References:
Clinical trial NCT04245787: Remineralization Potential of Curodont Repair Flouride Plus Versus CPP-ACP in Management of White Spot Lesions: Randomized Clinical Trial
Official title: Remineralization Potential of Curodont Repair Flouride Plus Versus CPP-ACP in Management of White Spot Lesions: Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: White Spot Lesion
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-01-29
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of modern dentistry is to manage non-cavitated caries lesions non- invasively through re-mineralization process to prevent the disease progression and improve aesthetics, strength, and function. Re-mineralization is defined as the process that supplies calcium, phosphate and flouride ions from an external source to the tooth to convert ion deposition into crystal voids in demineralized enamel. White spot lesions should be managed using a multifactorial approach. The most important strategy is to prevent demineralization and biofilm formationand use of methodologies for remineralization of lesions .

Self-assembling peptide (P11-4) has shown great potential for natural repair of early caries lesions through emerging biomimetic re-mineralization properties. (Takahashi Fet al in 2015) This peptide forms a 3D matrix within demineralized carious lesions areas, which enables novo hydroxyapatite crystal formation facilitating the so-called guided enamel regeneration of the lost enamel structure. The peptide has shown encouraging results as a scaffold for enamel regeneration


Eligibility criteria: Inclusion Criteria:

* Between the ages of 18 and 35 years of age female and males
* Had received conventional periodontal therapy
* Active carious white spot lesions
* No systemic diseases or concomitant medication affecting salivary flow

Exclusion Criteria:

* - Participant in another trial
* Non carious lesion (enamel hypoplasia and dental flourosis)
* Presence of abnormal oral, medical, or mental condition.
* Participants who had evidence of reduced salivary flow or significant tooth wear.
* Allergy to MI paste

Primary outcomes:
measure: Remineralization potential
timeFrame: T0:baseline assessment -->T1:1 month (Assessment of white spot lesion regression)--> T2:4 months(Application of Curodont repair flouride plus /Cpp-Acp andAssessment of white spot lesion regression)--> T3: 6 months Assessment of white spot lesion regres(
Secondary outcomes:
measure: Remineralization potential
timeFrame: T0:baseline assessment -->T1:1 month (Assessment of white spot lesion regression)--> T2:4 months(Application of Curodont repair flouride plus /Cpp-Acp andAssessment of white spot lesion regression)--> T3: 6 months( Assessment of white spot lesion regres
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty Of Oral & Dental Medicine - Cairo University
Study officials:
References:
Clinical trial NCT02836587: The Influence of Balance Training on Postural Control in Elderly
Official title: The Influence of Balance Training on Postural Control in Elderly
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Accidental Falls
Lead sponsor: Palacky University
Sponsor class: OTHER
First posted: 2016-07-19
Enrollment: 44
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Fall related injuries are major health problem which effect especially elderly population. After experiencing a fall, most of the elderly are unable to resume their previous mobility and the fear of future falls affects their daily life. Falls in elderly population are often related to balance or gait problems. The aim of this study is to assess the influence of balance training on postural and motor control of healthy elderly participants. The study is designed as a parallel interventional study with experimental and control group (allocation ratio 1:1). Participants' general health, balance abilities, fear of falling and gait stability and variability will be assessed on the baseline measurement, right after and 2 months after the completion of the training programme. Experimental group will undergo training focused on development of balance abilities and strength twice a week (60 minutes in length each) for 8 weeks. Participants will receive individualized exercises which will be focused on the main 4 types - stance exercises, gait and transition exercises and strength exercises especially focused on muscle strength of lower extremities.


Eligibility criteria: Inclusion Criteria:

* age 60+
* ability to stand and walk without aid or support
* participation in the institutional program "Falls risk and balance assessment" with successful completion of one year of observation for falls

Exclusion Criteria:

* neuromuscular or orthopaedic impairments that severely limit mobility and balance
* surgery or injury on the musculoskeletal system less than 2 years before baseline measurement
* any acute illness

Primary outcomes:
measure: Change from baseline Berg balance scale score after completing intervention
timeFrame: 2 months
measure: Change from baseline mean velocity of centre of pressure during quiet stance after completing intervention
timeFrame: 2 months
measure: Change from baseline stride time variability after completing intervention
timeFrame: 2 months
Secondary outcomes:
measure: Change from baseline Falls efficacy scale - International score after completing intervention
timeFrame: 2 months
measure: Change from baseline gait velocity after completing intervention
timeFrame: 2 months
measure: Change from baseline short-term Lyapunov exponents after completing intervention
timeFrame: 2 months
Other outcomes:
Locations:
city: Olomouc
country: Czechia
facility: Faculty of Physical Culture, Palacky University Olomouc
Study officials:
affiliation: Faculty of Physical Culture, Palacky University Olomouc
name: Zdenek Svoboda, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06228287: From Great Surgeons to Brilliant Observators, Evolution of Penetrating Neck Trauma in a Single Center Reference in Spain
Official title: From Great Surgeons to Brilliant Observators, Evolution of Penetrating Neck Trauma in a Single Center Reference in Spain
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Penetrating Neck Trauma
Keywords: Penetrating Trauma
Trauma surgery
No zone approach
Non-surgical treatment
Polytrauma
Lead sponsor: Hospital del Mar
Sponsor class: OTHER
First posted: 2024-01-29
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with a penetrating trauma in the neck admitted in Hospital del Mar from 2008 to 2022.

Brief summary: Penetrating neck trauma ranges from 5 to 10% of trauma patients and its management has been changing in the las 20 years and not all surgeons that attend this patients are trauma surgeons. The aim of the study is to describe the evolution of the management in a referal center and the complications of two periods, with and without a simplified protocol.

Detailed description: Penetrating neck trauma ranges from 5 to 10% of trauma patients and its management has been changing in the las 20 years and not all surgeons that attend this patients are trauma surgeons.

Traditionally, the management was followed by surgical treatment, but the non-therapeutic cervicotomies were ascendent to the 89%, the zone approach was established, following the Monson anatomy zones, with different indications for surgery in every zone, and finally, after the year 2000, started to publish articles on where the injury was not correlated with the zone in about a 23% of the patients.

The aim of the study is to describe the evolution of the management in a referal center and the complications of two periods, with and without a simplified no zone approach protocol.

Eligibility criteria: Inclusion Criteria:

* All penetrating trauma patients admitted in the emergency department.

Exclusion Criteria:

* All patients with any other diagnostic different from penetrating trauma
* Blunt trauma patients admitted in the emergency department

Primary outcomes:
measure: Complications
timeFrame: 2008-2022
measure: Mortality
timeFrame: 2008-2022
measure: Non-therapeutic cervicotomy
timeFrame: 2008-2022
Secondary outcomes:
measure: Demographyc description
timeFrame: 2008-2022
measure: Physiologic description
timeFrame: 2008-2022
measure: Wound
timeFrame: 2008-2022
Other outcomes:
Locations:
Study officials:
affiliation: Hospital del Mar
name: Ana María González Castillo
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00864487: Study Evaluating The Potential Effect Of Rifampin On The Pharmacokinetics Of Neratinib
Official title: A Study to Examine the Potential Effect of Rifampin on the Pharmacokinetics of Neratinib When Administered Concomitantly to Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy Subjects
Lead sponsor: Puma Biotechnology, Inc.
Sponsor class: INDUSTRY
First posted: 2009-03-18
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to examine whether co-administration of rifampin with neratinib has an effect on the pharmacokinetics (how the body absorbs, distributes, metabolizes and/or excretes) of neratinib.


Eligibility criteria: Inclusion criteria:

* Healthy men or women (of non childbearing potential)
* Ages 18 to 50 years old.

Primary outcomes:
measure: Pharmacokinetics (plasma blood concentrations)
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Miami
country: United States
state: Florida
Study officials:
affiliation: Biotechnology
name: Puma
role: STUDY_DIRECTOR
References: