louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01881698: Evaluation of Platelet Function in Pregnancy With Multiple Electrode Aggregometry
Official title: Multiple Electrode Aggregometry and Platelet Function in Pregnancy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Platelet Function
Pregnancy
Keywords: pregnancy
platelet function
monitoring
multiple electrode aggregometry
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2013-06-20
Enrollment: 200
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pregnant patients above the age of majority

Brief summary: Establishment of a range of normal values in pregnancy with the Multiple Electrode Aggregometry (Multiplate@) device, a device that allows measurement of not only platelet count but platelet function. This has not been studied in ths special patient group. Results from this trial will be used as a basis for further investigation of abnormal platelet function in pregnancy.


Eligibility criteria: Inclusion Criteria:

* pregnancy

Exclusion Criteria:

* Rejection of informed consent

Primary outcomes:
measure: Change of platelet function
timeFrame: 4x, as specified below
Secondary outcomes:
measure: Platelet-associated complications
timeFrame: 4x, as specified below (baseline, 20th week)
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Universitätsklinik für Frauenheilkunde, Allgemeines Krankenhaus der Stadt Wien
Study officials:
affiliation: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University Vienna
name: Reinhard Hahn, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06028698: Effects of Music on Table Tennis Stroke Performance Among Mentally Fatigued University Players
Official title: Effects of Music on Table Tennis Stroke Performance Among Mentally Fatigued University Players
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mental Fatigue
Lead sponsor: Universiti Putra Malaysia
Sponsor class: OTHER
First posted: 2023-09-08
Enrollment: 64
Sex: ALL
Minimum age (years): 18
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The current study is going to investigate the music intervention on the table tennis stroke performance among table tennis stroke performance. The subjects will be instructed to listen to 3 minutes, which can facilitate the recovering process for scope of attention and thought-action repertoire. Thus, to see the improvement in stroke performance.

Detailed description: The intervention of this study is music, specifically, instruct subjects to listen inducing positive emotion music due to positive emotion benefit to cognition performance.

The condition of mental fatigue will be induced by Stroop task. Before the intervention or process of listening music, the pre-test will be recorded to compare the post-test value of table tennis stroke performance.

Moreover, the different music intervention will be implemented to identify the optimal selection.

Eligibility criteria: Inclusion Criteria:

* University table tennis players. 18-24 years.
* Both pen-holder and shake-hand play styles.
* At least played from the senior school.
* At least have 3 years' training experience.

Exclusion Criteria:

* Color blindness.
* Any disease or sleep disorder.
* Smoker or drunker

Primary outcomes:
measure: table tennis stroke performance
timeFrame: 4 weeks
measure: Ball speed
timeFrame: 4 weeks
measure: Ball accuracy
timeFrame: 4 weeks
Secondary outcomes:
measure: Emotion state
timeFrame: 4 weeks
measure: Scope of attention
timeFrame: 4 weeks
measure: Thought-action repertoire
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Huai'an
country: China
facility: Cong Ding
state: Jiangsu
Study officials:
References:
Clinical trial NCT06621498: Ridge Preservation Using Guided Regenaration, Platelet-rich Plasma and Free Gingival Grafts
Official title: Ridge Preservation Using Guided Regenaration, Platelet-rich Plasma and Free Gingival Grafts
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post-Extraction Socket Healing
Ridge Preservation
Keywords: ridge preservation
post-extraction healing
post-extraction resorption
dense polytetrafluoroethylene membrane
free gingival graft
platelet-rich plasma
Lead sponsor: Medical University of Varna
Sponsor class: OTHER
First posted: 2024-10-01
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The goal of this clinical trial is to learn if ridge preservation methods with dense polytetrafluoroethylene membranes, with d-PTFE membranes and platelet-rich plasma, and with free gingival grafts can reduce vertical resorption of the post-extraction socket walls.

Researchers compared each experimental group to a control group (unassisted socket healing). Participants were randomly allocated to one of the four groups.

Cone-beam computed tomography was performed after the procedure and 3 months post-operatively to evaluate the vertical socket wall resorption.


Eligibility criteria: Inclusion Criteria:

1. Patients in the age group 18-65 years;
2. Patients in good general condition;
3. Patients requiring extraction of premolars or molars;
4. Patients in whom restoration of the missing tooth with a dental implant and/or prosthetic construction is planned;
5. Signed informed consent to participate in the study.

Exclusion Criteria:

1. Patients with contraindications for general surgical treatment:

   * patients with uncontrolled arterial hypertension;
   * patients with uncontrolled metabolic diseases;
   * patients with AMI in the last 6 months;
   * patients on hemodialysis treatment;
   * patients who underwent chemotherapy and/or radiotherapy in the last year;
   * patients on immunosuppressive therapy;
   * patients on anti-resorptive and anti-angiogenic therapy;
   * patients with concomitant acute diseases at the time of the study;
   * patients with proven psychiatric diseases;
   * pregnancy.
2. There are local contraindications:

   * insufficient volume of bone after the extraction to carry out RP;
   * acute inflammatory disease or tumor process in the area;
3. Lack of informed consent.
4. Lack of patient motivation for the treatment.

Primary outcomes:
measure: Vertical post-extraction resorption of the socket walls
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Varna
country: Bulgaria
facility: Medical University Varna
Study officials:
affiliation: Medical University of Varna
name: Stefan V Peev, DsC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00590798: Star-Close Early Ambulation Trial
Official title: Star-Close Early Ambulation Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiovascular Disease
Keywords: Cardiac Catheterization
Walk
Heart Catheterization
Coronary Disease
Heart Disease
Coronary Artery Disease
Lead sponsor: Ohio State University
Sponsor class: OTHER
First posted: 2008-01-11
Enrollment: 58
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: To confirm that patients who receive the Star-Close vascular closure system (VCS) can safely ambulate within 30 minutes of catheterization.

Detailed description: To confirm that patients who receive the Star-Close vascular closure system (VCS) after diagnostic cardiac catheterization can safely ambulate within 30 minutes of catheterization.

Eligibility criteria: Inclusion Criteria:

* Patients admitted to for an outpatient left heart catheterization
* Catheterization through the femoral artery
* Able to ambulate at least 20 feet
* Able to receive the Star-Close Vascular Closure System
* Be a candidate for hospital discharge following catheterization

Exclusion Criteria:

* Known peripheral arterial disease
* Blood pressure greater than 180/110
* Pregnant or lactating
* Anemic or low blood count
* Blood thinning medication within 5 days before catheterization
* Unable to walk 20 feet with out rest
* Complications during catheterization procedure

Primary outcomes:
measure: Occurrence or absence of adverse outcomes after ambulation within 30 minutes of cardiac catheterization
timeFrame: 7 days post procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Columbus
country: United States
facility: The Ohio State University Medical Center
state: Ohio
Study officials:
affiliation: The Ohio State University Medical Center, Division of Cardiovascular Medicine
name: Earnest L Mazzaferri Jr, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01130298: An Open-Label Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure to Testosterone Gel 1.62% Applied to the Upper Arms and Shoulders and Use of a T-shirt Barrier
Official title: An Open-Label Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure to Testosterone Gel 1.62% Applied to the Upper Arms and Shoulders and Use of a T-shirt Barrier
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Keywords: testosterone,
Pharmacokinetics
replacement,
therapy
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2010-05-26
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Single-center, single dose, open-label study in healthy male and female volunteers to further characterize the transfer potential of Testosterone Gel 1.62% formulation.

Detailed description: Single-center, single dose, open-label study in 12 healthy male and 12 healthy female volunteers to further characterize the transfer potential of Testosterone Gel 1.62% formulation.

Eligibility criteria: Inclusion Criteria

* BMI between 20-35 kg/m\^2 inclusive.

Exclusion Criteria

* Males: history, current or suspected prostate or breast cancer.
* Females: pregnant or lactating.

Primary outcomes:
measure: Maximum Plasma Concentration observed (Cmax)
timeFrame: Up to 5 days
measure: Area Under the Plasma Concentration-time Curve (AUC)
timeFrame: Up to 5 days
measure: Average Plasma Concentration observed (Cav)
timeFrame: Up to 5 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Abbott
name: Michael Miller, PharmD
role: STUDY_DIRECTOR
References:
citation: Stahlman J, Britto M, Fitzpatrick S, McWhirter C, Testino SA, Brennan JJ, Zumbrunnen TL. Serum testosterone levels in non-dosed females after secondary exposure to 1.62% testosterone gel: effects of clothing barrier on testosterone absorption. Curr Med Res Opin. 2012 Feb;28(2):291-301. doi: 10.1185/03007995.2011.652732. Epub 2012 Jan 24.
Clinical trial NCT01712698: Diffusion Tensor Imaging to Assess the Functional Outcomes of Adults With Cervical Spinal Cord Injuries
Official title: Diffusion Tensor MRI to Assess Subacute Functional Outcomes in Patients With Acute Cervical Spinal Cord Injuries
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Cervical Spinal Cord Injury
Keywords: trauma
spinal cord injury
cervical spine
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2012-10-23
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with a traumatic cervical spinal cord injury

Brief summary: Acute changes in axial diffusivity will correlate with the severity of injury in patients that suffer an acute spinal cord injury.

Detailed description: Diffusion tensor imaging (DTI) parameters will correlate with severity of spinal cord injury in SCI patients as seen in rodent models. We will test whether the quantitative decrease in axial (λ║) diffusivity (a biomarker of axonal injury), will predict long-term functional outcomes for patients with a SCI.

Specific Aim: To examine patients after an acute SCI using DTI and to correlate the extent of acute decrease in λ║ with the presenting ASIA motor score and long-term functional outcome of the patient.

Eligibility criteria: Inclusion Criteria:

* 18-65 years of age
* Cervical spinal cord injury
* physically and mentally willing to comply with imaging
* lives in immediate area with no plans to relocate

Exclusion Criteria:

* Associated moderate to severe head injury
* Active malignancy
* Previous spinal cord injury
* pregnancy
* inability to tolerate MRI scanning

Primary outcomes:
measure: Change in AISA score
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University, School of Medicine
state: Missouri
Study officials:
References:
Clinical trial NCT02945098: Kinesio Taping in Muscle Damage Response Induced by Eccentric Exercise
Official title: Kinesio Taping® Does Not Interfere in Muscle Damage Response Induced by Eccentric Exercise: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bandages
Muscle Soreness
Lead sponsor: Universidade Federal do Rio Grande do Norte
Sponsor class: OTHER
First posted: 2016-10-26
Enrollment: 60
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 28
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Sixty volunteers with a mean age of 21,8 ± 2,6 years participated in this study, randomly distributed into one of the following groups: control, Kinesio taping group with tension in the anterior arm region and Kinesio taping group without tension in the same region. All subjects underwent an eccentric exercise protocol and three evaluations: before the protocol, immediately after and 48h after protocol. The following variables were analyzed: sensation of pain as the primary outcome; peak torque normalized by body weight; average peak torque; total work and average power, using an isokinetic dynamometer. In addition, muscle activation amplitude (Root Mean Square) and median frequency were recorded using surface electromyography.


Eligibility criteria: Inclusion Criteria:

* Female between 18 and 28 years;
* BMI below 30;
* Practicing recreational physical activity at least three times a week without training at a competitive level;
* Exhibiting shoulder joint, elbow and non-dominant hand integrity;
* Do not having a history of osteo-myoarticular injuries in the assessed limb in the last 6 months.

Exclusion Criteria:

* Does not run the tests properly;
* Be allergic to tape test;
* Does not attend all assessments.

Primary outcomes:
measure: Visual analogue scale
timeFrame: Change from baseline in visual analogue scale at one hour and three days
Secondary outcomes:
Other outcomes:
Locations:
city: Natal
country: Brazil
facility: Federal University of Rio Grande do Norte
state: RN
Study officials:
References:
Clinical trial NCT02198898: Anti-adhesion Effect of GUARDIX-SGⓇ in Gastric Cancer Surgery
Official title: Prospective Multicenter Trial for Anti-adhesion Effect of GUARDIX-SGⓇ Following Radical Gastrectomy in Patients With Gastric Cancer.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Adhesive Intestinal Obstruction
Lead sponsor: The Catholic University of Korea
Sponsor class: OTHER
First posted: 2014-07-24
Enrollment: 224
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study is to evaluate the efficacy of GUARDIX-SGⓇ for patients with gastrectomy in Korea and the investigators hypothesized applying of adhesive preventing agent would reduce incidence of adhesive obstruction after gastrectomy.

Detailed description: Adhesive bowel obstruction is relatively often complication in patients after abdominal surgery

Gastric cancer is the most frequent cancer in Korea.

The incidence of adhesive bowel obstruction would be increased in patients with gastric cancer, especially associated radical lymphadenectomy.

The causes of postoperative adhesive obstruction include adhesion of the wound, adhesion of small intestine to small intestine, adhesion of the small intestine to other abdominal organs, and internal hernia.

Several studies reported efficacy of adhesive preventing agent after colorectal resection.

Gastrectomy is associated with a high risk (incidence, 11.7%-38.5%) of bowel obstruction.

To date, however, no randomized study has shown that GUARDIX-SGⓇ reduces the rate of small bowel obstruction after gastrectomy with radical lymphadenectomy for gastric cancer.

Eligibility criteria: Inclusion Criteria:

* Patients with gastric adenocarcinoma who scheduled to undergo open gastrectomy
* Informed consents

Exclusion Criteria:

* Pregnant
* Ascites
* Liver dysfunction
* Renal failure
* Past history of abdominal operation or small bowel obstruction

Primary outcomes:
measure: incidence of adhesive intestinal obstruction
timeFrame: up to 1 years after operation (every 3 month)
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul St. Mary's Hospital
Study officials:
affiliation: The Catholic University of Korea
name: Kyo Young Song, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04685798: Optimized Diffusion-Weighted Imaging for the Evaluation of Post-Treatment Squamous Cell Carcinoma in the Neck: Comparative Study With FDG PET/CT
Official title: Optimized Diffusion-Weighted Imaging for the Evaluation of Post-Treatment Squamous Cell Carcinoma in the Neck: Comparative Study With FDG PET/CT
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Squamous Cell Carcinoma
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2020-12-28
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The investigators propose a longitudinal study evaluating post-treatment changes in patients with squamous cell carcinoma (SCC) of the neck using an innovative optimized diffusion-weighted imaging (DWI) pulse sequence to identify more accurately recurrent tumors as well as early non-responders to therapy.


Eligibility criteria: Inclusion Criteria:

* Histologically-proven newly diagnosis or recurrence as indicated by tissue diagnosis of T3 or T4 squamous cell carcinoma of the head and neck
* Must have had or be scheduled for standard-of-care surgical resection, radiation, and/or chemo-radiation of the diagnosed squamous cell carcinoma of the head and neck
* At least 18 years of age
* Patient must be able to understand and willing to sign a written informed consent document.

Exclusion Criteria:

* Contraindications to MRI, including:

  * MRI-incompatible implantable devices
  * severe claustrophobia; and
* Pregnant and/or breastfeeding, with women of childbearing potential having a negative urine or serum pregnancy test

Primary outcomes:
measure: Apparent Diffusion Coefficient Mean (ADCmean)
timeFrame: 2-3 weeks post-standard of care treatment
measure: Apparent Diffusion Coefficient Lowest Value in a Tumor (ADCmin)
timeFrame: 2-3 weeks post-standard of care treatment
Secondary outcomes:
measure: Number of Participants That Were Non-responders to Treatment on Both the DWI MRI and the Standard of Care FDG PET/CT
timeFrame: 2-3 weeks post-standard of care treatment
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
Study officials:
affiliation: Washington University School of Medicine
name: Gloria J Guzman Pérez-Carrillo, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01542398: A Family-based, Resilience-focused Intervention for War-affected Communities in North-eastern Democratic Republic of Congo
Official title: Title: Is a Family-based, Life Skills Focused Intervention Effective in Reducing Psychological Distress and Stigma and Improving Inter-personal Relations and Functioning Among Former LRA Abductees and Other War-affected Children in Their Community in Dungu, the Democratic Republic of Congo?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Psychological Distress
Keywords: community-based
war-affected
psychosocial support
family-focused
psychological distress
adolescents
Democratic Republic of Congo
family functioning
community functioning
daily functioning
Lead sponsor: Queen's University, Belfast
Sponsor class: OTHER
Collaborators: name: Harvard School of Public Health (HSPH)
name: Discover the Journey
First posted: 2012-03-02
Enrollment: 159
Sex: ALL
Minimum age (years): 7
Maximum age (years): 99
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The main research question of the study is whether a family-based, life-skills focused psychosocial intervention is effective in reducing psychological distress and stigma and improving inter-personal relations and functioning among war-affected children in the Democratic Republic of Congo.


Eligibility criteria: Inclusion Criteria:

* War-affected
* eastern Democratic Republic of Congo
* Formerly abducted child or vulnerable child

Exclusion Criteria:

* severe/violent behavioural problems
* severe learning difficulties

Primary outcomes:
measure: Reduction in Post-traumatic Stress Reaction Symptoms Among Participants
timeFrame: 1-week before intervention, 3-weeks later
Secondary outcomes:
measure: African Youth Psychosocial Assessment Inventory - Depression and Anxiety Subscales
timeFrame: pre-intervention, 3 weeks later
Other outcomes:
Locations:
city: Dungu
country: Congo
facility: Dungu
state: Haut-Uele
Study officials:
affiliation: British Psychological Society (Chartered Clinical Psychologist)
name: Ciarán Shannon, BA, MA, DClin
role: STUDY_DIRECTOR
References:
citation: O'Callaghan P, Branham L, Shannon C, Betancourt TS, Dempster M, McMullen J. A pilot study of a family focused, psychosocial intervention with war-exposed youth at risk of attack and abduction in north-eastern Democratic Republic of Congo. Child Abuse Negl. 2014 Jul;38(7):1197-207. doi: 10.1016/j.chiabu.2014.02.004. Epub 2014 Mar 15.