Clinical trial NCT05870644: Acute Effects of Exercise at Different Temperatures in Allergic Rhinitis Patient
Official title: Acute Effects of Exercise at Different Temperatures on Nasal Blood Flow and Symptoms in Patient With Allergic Rhinitis.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Allergic Rhinitis
Keywords: aerobic exercise
allergic rhinitis
nasal blood flow
peak nasal inspiratory flow
acute exercise
Lead sponsor: Chulalongkorn University
Sponsor class: OTHER
First posted: 2023-05-23
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Fifteen patients with allergic rhinitis aged between 18 and 35 years who had a positive skin prick test to house dust mite (D. pteronyssinus). The experiment was a crossover design in which each participant was given aerobic exercise by ergometer in two difference temperatures room : 25 degree celsius and 34 degree celsius. Rhinitis symptoms, nasal blood flow, heart rate, and oxygen saturation were measured before, during exercise at 15, 30, and 45 minutes, and after exercise at 0, 15 and 30 minutes in each temperature. Moreover, blood pressure, peak nasal inspiratory flow, pulmonary functions, respiratory muscle strength, and fractional exhaled nitric oxide were measured before and after exercise at 0, 15 and 30 minutes in each temperature.
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to determine the effects of exercise at different temperatures on nasal blood flow and symptoms in allergic rhinitis patients.

Detailed description: Fifteen patients with allergic rhinitis aged between 18 and 35 years who had a positive skin prick test to house dust mite (D. pteronyssinus). The experiment was a crossover design in which each participant was given aerobic exercise by ergometer in two difference temperatures room : 25 degree celsius and 34 degree celsius. Rhinitis symptoms, nasal blood flow, heart rate, and oxygen saturation were measured before, during exercise at 15, 30, and 45 minutes, and after exercise at 0, 15 and 30 minutes in each temperature. Moreover, blood pressure, peak nasal inspiratory flow, pulmonary functions, respiratory muscle strength, and fractional exhaled nitric oxide were measured before and after exercise at 0, 15 and 30 minutes in each temperature.

Eligibility criteria: Inclusion Criteria:

* Subjects had a clinical history of persistent rhinitis, and had positive skin prick test to house dust mite (D. pteronyssinus)
* Persistent allergic rhinitis
* Subjects with known asthma, chronic rhinosinusitis, Lung cancer and Emphysema diseases were excluded.
* BMI 18.5 - 24.9 kg/m2
* Subjects will ask to abstain from taking antihistamine for at least 5 days, leukotriene receptor antagonist for at least 1 week, and nasal steroids for at least 2 weeks prior to the start of the experiment.
* Subjects will ask to abstain from taking any form of dietary supplement during the experiment.
* Subjects had no exercise training program (not exercise regularly or not exercise for 30 minutes or more at least 3 times per week during the past 6 months)

Exclusion Criteria:

* Accident that are unable to continue the research, such as accidental injury or illness, etc.
* Participants did not voluntarily participate.

Primary outcomes:
measure: Rhinitis symptom scores change
timeFrame: Change among before, during exercise at 15, 30, and 45 minutes, and after exercise at 0, 15 and 30 minutes in each temperature.
measure: Nasal blood flow change
timeFrame: Change among before, during exercise at 15, 30, and 45 minutes, and after exercise at 0, 15 and 30 minutes in each temperature.
measure: Peak nasal inspiratory flow change
timeFrame: Change before and after exercise at 0, 15 and 30 minutes in each temperature.
Secondary outcomes:
measure: Fractional exhaled nitric oxide
timeFrame: Change before and after exercise at 0, 15 and 30 minutes in each temperature.
measure: Pulmonary functions change
timeFrame: Change before and after exercise at 0, 15 and 30 minutes in each temperature.
measure: Respiratory muscle strength change
timeFrame: Change before and after exercise at 0, 15 and 30 minutes in each temperature.
Other outcomes:
Locations:
city: Pathum Wan
country: Thailand
facility: Faculty of Sports Science, Chulalongkorn University
state: Bangkok
Study officials:
References:
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