Clinical trial NCT05315869: a Retrospective Observational Study Comparing Outcomes of Retrocaecal Appendicitis With Non-retrocaecal Appendicitis
Official title: Retrocaecal Appendicitis: Risk Factor for Perioperative Complications?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Appendicitis
Appendicitis Acute
Retrocecal Appendicitis
Lead sponsor: Faculty Hospital Kralovske Vinohrady
Sponsor class: OTHER_GOV
First posted: 2022-04-07
Enrollment: 754
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients of the treated at the department of surgery of the University Hospital Kralovske Vinohrady

Brief summary: A retrospective observational study investigating whether retrocecal appendicitis associated with worse operative and postoperative outcomes than non-retrocecal appendicitis.

Detailed description: Acute appendicitis is the most common cause of acute abdomen requiring acute surgery. The prevalence of the retrocaecal position of the appendix varies significantly between studies from 14 to 36%. Appendectomy of a retrocecal appendix is generally considered to be more demanding procedure than appendectomy of appendices in other positions. The aim of this study is to investigate whether retrocaecal appendicitis is associated with a higher rate of perioperative complications and delayed diagnosis when compared with the other positions.

A retrospective analysis of prospectively collected data of patients undergoing surgery for signs of acute appendicitis from January 2015 to April 2020 at the University Hospital Kralovske Vinohrady. Two groups of patients were be formed: the retrocaecal group and the non-retrocaecal group.

The following data were recorded: sex, age, body mass index, length of hospital stay, abdominal drain placement, length of surgery, surgical approach (laparoscopic, open or converted), operative finding (normal appendix or catarrhal, phlegmonous, gangrenous, or perforated appendicitis), position of the appendix (retrocaecal or non-retrocaecal positions), histopathological findings (acute inflammation, chronic inflammation, appendiceal tumour or normal appendix), 30-day postoperative complications, 30-day postoperative mortality, symptoms (abdominal pain, nausea, vomiting, diarrhoea, body temperature above 37 degrees celsius, urological complaints and gynaecological complaints), duration of symptoms (from onset to surgery), serious comorbidities and diabetes mellitus.

Eligibility criteria: Inclusion Criteria:

* All patients undergoing surgery for signs of acute appendicitis at the department of surgery of the University Hospital Kralovske Vinohrady between January 2015 to April 2020

Exclusion Criteria:

* Patients under 18 years of age

Primary outcomes:
measure: Number of patient with postoperative complications
timeFrame: 30 days after intervention (appendectomy)
measure: Number of patient who undergo converted appendectomy
timeFrame: during the surgery
measure: Length of hospital stay
timeFrame: 30 days after intervention (appendectomy)
measure: Duration of procedure
timeFrame: Throughout the study period (1/2015-4/2020)
Secondary outcomes:
Other outcomes:
Locations:
city: Praha 3
country: Czechia
facility: Adam Whitley
state: Prague
Study officials:
affiliation: University Hospital Kralovske Vinohrady
name: Adam Whitley, MUDr.
role: STUDY_CHAIR
References: