Clinical trial NCT04793958: Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
Official title: A Randomized Phase 3 Study of MRTX849 in Combination With Cetuximab Versus Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation With Disease Progression On or After Standard First-Line Therapy
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Advanced Colorectal Cancer
Metastatic Colorectal Cancer
Keywords: Colorectal Cancer
Colorectal Cancer Trial
Colorectal Carcinoma
Rectal Cancer
Colon Cancer
KRAS
KRAS G12C
RAS
Colorectal Adenocarcinoma
Lead sponsor: Mirati Therapeutics Inc.
Sponsor class: INDUSTRY
First posted: 2021-03-11
Enrollment: 461
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Study CA239-0006 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.


Eligibility criteria: Inclusion Criteria:

* Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
* Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Exclusion Criteria:

* Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
* Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
* Active brain metastasis

Primary outcomes:
measure: Overall Survival (OS)
timeFrame: 30 months
measure: Progression-free Survival (PFS)
timeFrame: 30 months
Secondary outcomes:
measure: Adverse Events
timeFrame: 30 months
measure: Objective Response Rate (ORR)
timeFrame: 30 months
measure: Duration of Response (DOR)
timeFrame: 30 months
measure: Patient Reported Outcomes (PROs)
timeFrame: 30 months
measure: Quality of Life Assessment
timeFrame: 30 months
Other outcomes:
Locations:
city: Alabaster
country: United States
facility: Local Institution - 010-855-E
state: Alabama
city: Bessemer
country: United States
facility: Local Institution - 010-855-B
state: Alabama
city: Birmingham
country: United States
facility: Local Institution - 010-855-D
state: Alabama
city: Birmingham
country: United States
facility: Local Institution - 010-855-A
state: Alabama
city: Birmingham
country: United States
facility: Local Institution - 010-855-F
state: Alabama
city: Birmingham
country: United States
facility: Local Institution - 010-855-C
state: Alabama
city: Birmingham
country: United States
facility: Local Institution - 010-855
state: Alabama
city: Gilbert
country: United States
facility: Local Institution - 010-996
state: Arizona
city: Goodyear
country: United States
facility: Local Institution - 010-566
state: Arizona
city: Phoenix
country: United States
facility: Local Institution - 010-989
state: Arizona
city: Springdale
country: United States
facility: Local Institution - 010-978
state: Arkansas
city: Bakersfield
country: United States
facility: Local Institution - 010-573
state: California
city: Chula Vista
country: United States
facility: Local Institution - 010-979C
state: California
city: Fresno
country: United States
facility: Local Institution - 010-980
state: California
city: Fullerton
country: United States
facility: Local Institution - 010-851
state: California
city: La Mesa
country: United States
facility: Local Institution - 010-979A
state: California
city: Los Angeles
country: United States
facility: Local Institution - 010-958A
state: California
city: Los Angeles
country: United States
facility: Local Institution - 010-958
state: California
city: Los Angeles
country: United States
facility: Local Institution - 010-551
state: California
city: Newport Beach
country: United States
facility: Local Institution - 010-847
state: California
city: Redlands
country: United States
facility: Local Institution - 010-563
state: California
city: San Diego
country: United States
facility: Local Institution - 010-979B
state: California
city: San Diego
country: United States
facility: Local Institution - 010-979D
state: California
city: San Diego
country: United States
facility: Local Institution - 010-979
state: California
city: San Francisco
country: United States
facility: Local Institution - 010-982
state: California
city: Santa Monica
country: United States
facility: Local Institution - 010-561
state: California
city: Sylmar
country: United States
facility: Local Institution - 010-571
state: California
city: Torrance
country: United States
facility: Local Institution - 010-574
state: California
city: Whittier
country: United States
facility: Local Institution - 010-570
state: California
city: Aurora
country: United States
facility: Local Institution - 010-872-H
state: Colorado
city: Aurora
country: United States
facility: Local Institution - 010-810
state: Colorado
city: Boulder
country: United States
facility: Local Institution - 010-872-A
state: Colorado
city: Centennial
country: United States
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state: Colorado
city: Colorado Springs
country: United States
facility: Local Institution - 010-872-C
state: Colorado
city: Denver
country: United States
facility: Local Institution - 010-872
state: Colorado
city: Denver
country: United States
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state: Colorado
city: Lakewood
country: United States
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state: Colorado
city: Littleton
country: United States
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city: Longmont
country: United States
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state: Colorado
city: Pueblo
country: United States
facility: Local Institution - 010-872-I
state: Colorado
city: Thornton
country: United States
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state: Colorado
city: Norwich
country: United States
facility: Local Institution - 010-949
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city: Bonita Springs
country: United States
facility: Local Institution - 010-922-A
state: Florida
city: Bradenton
country: United States
facility: Local Institution - 010-922-D
state: Florida
city: Cape Coral
country: United States
facility: Local Institution - 010-922-E
state: Florida
city: Fort Myers
country: United States
facility: Local Institution - 010-922
state: Florida
city: Fort Myers
country: United States
facility: Local Institution - 010-922-B
state: Florida
city: Fort Myers
country: United States
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state: Florida
city: Holiday
country: United States
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state: Florida
city: Jacksonville
country: United States
facility: Local Institution - 010-829
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-A
state: Florida
city: Largo
country: United States
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state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-C
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-D
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-E
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-F
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-G
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-H
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-I
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-J
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-K
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-L
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-M
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-N
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-O
state: Florida
city: Largo
country: United States
facility: Local Institution - 010-923-P
state: Florida
city: Miami
country: United States
facility: Local Institution - 010-990
state: Florida
city: Naples
country: United States
facility: Local Institution - 010-922-F
state: Florida
city: Naples
country: United States
facility: Local Institution - 010-922-G
state: Florida
city: Ocala
country: United States
facility: Local Institution - 010-538
state: Florida
city: Orlando
country: United States
facility: Local Institution - 010-896
state: Florida
city: Orlando
country: United States
facility: Local Institution - 010-988
state: Florida
city: Port Charlotte
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state: Florida
city: Saint Petersburg
country: United States
facility: Local Institution - 010-923
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city: Saint Petersburg
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state: Florida
city: Tallahassee
country: United States
facility: Local Institution - 010-924
state: Florida
city: Trinity
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facility: Local Institution - 010-984-A
state: Florida
city: West Palm Beach
country: United States
facility: Local Institution - 010-926
state: Florida
city: Weston
country: United States
facility: Local Institution - 010-537
state: Florida
city: Atlanta
country: United States
facility: Local Institution - 010-956
state: Georgia
city: Newnan
country: United States
facility: Local Institution - 010-986
state: Georgia
city: Naperville
country: United States
facility: Local Institution - 010-963
state: Illinois
city: Zion
country: United States
facility: Local Institution - 010-994
state: Illinois
city: Indianapolis
country: United States
facility: Local Institution - 010-569-A
state: Indiana
city: Indianapolis
country: United States
facility: Local Institution - 010-569
state: Indiana
city: Iowa City
country: United States
facility: Local Institution - 010-991
state: Iowa
city: Baton Rouge
country: United States
facility: Local Institution - 010-920
state: Louisiana
city: Baltimore
country: United States
facility: Local Institution - 010-534
state: Maryland
city: Boston
country: United States
facility: Local Institution - 010-997
state: Massachusetts
city: Brownstown
country: United States
facility: Local Institution - 010-531A
state: Michigan
city: Dearborn
country: United States
facility: Local Institution - 010-531C
state: Michigan
city: Detroit
country: United States
facility: Local Institution - 010-531
state: Michigan
city: Novi
country: United States
facility: Local Institution - 010-531B
state: Michigan
city: Minneapolis
country: United States
facility: Local Institution - 010-875
state: Minnesota
city: Rochester
country: United States
facility: Local Institution - 010-830
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838A
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838B
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838C
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838D
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838E
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838F
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838G
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838H
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838I
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838J
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838K
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838L
state: Minnesota
city: Saint Louis Park
country: United States
facility: Local Institution - 010-838M
state: Minnesota
city: Springfield
country: United States
facility: Local Institution - 010-541
state: Missouri
city: Lincoln
country: United States
facility: Local Institution - 010-564
state: Nebraska
city: Omaha
country: United States
facility: Local Institution - 010-590
state: Nebraska
city: Henderson
country: United States
facility: Local Institution - 010-860 - A
state: Nevada
city: Henderson
country: United States
facility: Local Institution - 010-860-F
state: Nevada
city: Henderson
country: United States
facility: Local Institution - 010-860-B
state: Nevada
city: Las Vegas
country: United States
facility: Local Institution - 010-860-D
state: Nevada
city: Las Vegas
country: United States
facility: Local Institution - 010-860-C
state: Nevada
city: Las Vegas
country: United States
facility: Local Institution - 010-860-E
state: Nevada
city: Las Vegas
country: United States
facility: Local Institution - 010-860
state: Nevada
city: Basking Ridge
country: United States
facility: Local Institution - 010-918 - B
state: New Jersey
city: Belleville
country: United States
facility: Local Institution - 010-993
state: New Jersey
city: East Brunswick
country: United States
facility: Local Institution - 010-975
state: New Jersey
city: Florham Park
country: United States
facility: Local Institution - 010-992
state: New Jersey
city: Middletown
country: United States
facility: Local Institution - 010-918 - D
state: New Jersey
city: Montvale
country: United States
facility: Local Institution - 010-918 - C
state: New Jersey
city: New Brunswick
country: United States
facility: Local Institution - 010-957
state: New Jersey
city: Babylon
country: United States
facility: Local Institution - 010-535 - D
state: New York
city: Bronx
country: United States
facility: Local Institution - 010-535 - E
state: New York
city: Commack
country: United States
facility: Local Institution - 010-918 - A
state: New York
city: Harrison
country: United States
facility: Local Institution - 010-918 - F
state: New York
city: New York
country: United States
facility: Local Institution - 010-813
state: New York
city: New York
country: United States
facility: Local Institution - 010-535 - G
state: New York
city: New York
country: United States
facility: Local Institution - 010-998
state: New York
city: New York
country: United States
facility: Local Institution - 010-918
state: New York
city: Patchogue
country: United States
facility: Local Institution - 010-535 - C
state: New York
city: Port Jefferson Station
country: United States
facility: Local Institution - 010-535 - B
state: New York
city: Port Jefferson
country: United States
facility: Local Institution - 010-535 - A
state: New York
city: Riverhead
country: United States
facility: Local Institution - 010-535 - F
state: New York
city: Shirley
country: United States
facility: Local Institution - 010-535
state: New York
city: Uniondale
country: United States
facility: Local Institution - 010-918 - E
state: New York
city: Clinton
country: United States
facility: Local Institution - 010-585-B
state: North Carolina
city: Goldsboro
country: United States
facility: Local Institution - 010-585
state: North Carolina
city: Jacksonville
country: United States
facility: Local Institution - 010-585-A
state: North Carolina
city: Cincinnati
country: United States
facility: Local Institution - 010-893
state: Ohio
city: Oklahoma City
country: United States
facility: Local Institution - 010-532
state: Oklahoma
city: Oklahoma City
country: United States
facility: Local Institution - 010-549
state: Oklahoma
city: Tulsa
country: United States
facility: Local Institution - 010-584
state: Oklahoma
city: Pittsburgh
country: United States
facility: Local Institution - 010-596
state: Pennsylvania
city: Greenville
country: United States
facility: Local Institution - 010-981
state: South Carolina
city: Chattanooga
country: United States
facility: Local Institution - 010-921
state: Tennessee
city: Nashville
country: United States
facility: Local Institution - 010-801
state: Tennessee
city: Dallas
country: United States
facility: Local Institution - 010-572
state: Texas
city: Dallas
country: United States
facility: Local Institution - 010-879
state: Texas
city: Houston
country: United States
facility: Local Institution - 010-577-B
state: Texas
city: Houston
country: United States
facility: Local Institution - 010-577-A
state: Texas
city: Houston
country: United States
facility: Local Institution - 010-577
state: Texas
city: Houston
country: United States
facility: Local Institution - 010-848
state: Texas
city: Houston
country: United States
facility: Local Institution - 010-977
state: Texas
city: Irving
country: United States
facility: Local Institution - 010-999
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city: Longview
country: United States
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city: San Antonio
country: United States
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state: Texas
city: Temple
country: United States
facility: Local Institution - 010-964
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city: Tyler
country: United States
facility: Local Institution - 010-878
state: Texas
city: American Fork
country: United States
facility: Local Institution - 010-976-F
state: Utah
city: Bountiful
country: United States
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state: Utah
city: Layton
country: United States
facility: Local Institution - 010-976-D
state: Utah
city: Murray
country: United States
facility: Local Institution - 010-976-A
state: Utah
city: Ogden
country: United States
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state: Utah
city: Provo
country: United States
facility: Local Institution - 010-976-G
state: Utah
city: Salt Lake City
country: United States
facility: Local Institution - 010-976-B
state: Utah
city: Salt Lake City
country: United States
facility: Local Institution - 010-976
state: Utah
city: West Jordan
country: United States
facility: Local Institution - 010-976-E
state: Utah
city: Fairfax
country: United States
facility: Local Institution - 010-919
state: Virginia
city: Fredericksburg
country: United States
facility: Local Institution - 010-597
state: Virginia
city: Richmond
country: United States
facility: Local Institution - 010-539
state: Virginia
city: Richmond
country: United States
facility: Local Institution - 010-536
state: Virginia
city: Auburn
country: United States
facility: Local Institution - 010-533 A
state: Washington
city: Everett
country: United States
facility: Local Institution - 010-576
state: Washington
city: Gig Harbor
country: United States
facility: Local Institution - 010-533 B
state: Washington
city: Puyallup
country: United States
facility: Local Institution - 010-533 C
state: Washington
city: Seattle
country: United States
facility: Local Institution - 010-824
state: Washington
city: Tacoma
country: United States
facility: Local Institution - 010-533
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city: Vancouver
country: United States
facility: Local Institution - 010-885
state: Washington
city: Morgantown
country: United States
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state: West Virginia
city: Milwaukee
country: United States
facility: Local Institution - 010-947
state: Wisconsin
city: Buenos Aires
country: Argentina
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city: Buenos Aires
country: Argentina
facility: Local Institution - 010-431
city: Caba
country: Argentina
facility: Local Institution - 010-432
city: La Rioja
country: Argentina
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country: Argentina
facility: Local Institution - 010-448
city: Viedma
country: Argentina
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country: Australia
facility: Local Institution - 010-005
city: Clayton
country: Australia
facility: Local Institution - 010-004
city: Garran
country: Australia
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city: Heidelberg
country: Australia
facility: Local Institution - 010-015
city: Melbourne
country: Australia
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country: Australia
facility: Local Institution - 010-002
city: Innsbruck
country: Austria
facility: Local Institution - 010-145
city: Wiener Neustadt
country: Austria
facility: Local Institution - 010-143
city: Wien
country: Austria
facility: Local Institution - 010-144
city: Brussel
country: Belgium
facility: Local Institution - 010-154
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country: Belgium
facility: Local Institution - 010-157
city: Gent
country: Belgium
facility: Local Institution - 010-156
city: Yvoir
country: Belgium
facility: Local Institution - 010-150
city: Ijui
country: Brazil
facility: Local Institution - 010-446
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
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state: Rio Grande Do Sul
city: Blumenau
country: Brazil
facility: Local Institution - 010-450
state: Santa Catarina
city: Curitiba
country: Brazil
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city: Liberdade
country: Brazil
facility: Local Institution - 010-449
city: Santo Andre
country: Brazil
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city: Sao Jose do Rio Preto
country: Brazil
facility: Local Institution - 010-440
city: Sao Paolo
country: Brazil
facility: Local Institution - 010-441
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country: Brazil
facility: Local Institution - 010-445
city: Sao Paulo
country: Brazil
facility: Local Institution - 010-447
city: Ottawa
country: Canada
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state: Ontario
city: Toronto
country: Canada
facility: Local Institution - 010-483
state: Ontario
city: Toronto
country: Canada
facility: Local Institution - 010-482
state: Ontario
city: Montreal
country: Canada
facility: Local Institution - 010-487
state: Quebec
city: Bengbu
country: China
facility: Local Institution - 010-712
state: Anhui
city: Hefei Shi
country: China
facility: Local Institution - 010-026
state: Anhui
city: Hefei
country: China
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city: Hefei
country: China
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city: Beijing
country: China
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country: China
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city: Guangzhou
country: China
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city: Shenzhen
country: China
facility: Local Institution - 010-713
state: Guangdong
city: Nanning
country: China
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city: Zhengzhou City
country: China
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city: Wuhan
country: China
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city: Wuhan
country: China
facility: Local Institution - 010-701
state: Hubei
city: Changsha
country: China
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city: Jiangyin
country: China
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city: Nanjing
country: China
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city: Nanchang
country: China
facility: Local Institution - 010-706
state: Jiangxi
city: Changchun
country: China
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city: Changchun
country: China
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state: Jilin
city: Shenyang
country: China
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state: Liaoning
city: Shenyang
country: China
facility: Local Institution - 010-705
state: Liaoning
city: Jinan
country: China
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city: Shanghai Shi
country: China
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state: Shanghai
city: Shanghaishi
country: China
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state: Shanghai
city: Shanghai
country: China
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state: Shanghai
city: Shanghai
country: China
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state: Shanghai
city: Shanghai
country: China
facility: Local Institution - 010-708
state: Shanghai
city: Chengdu
country: China
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state: Sichuan
city: Neijiang
country: China
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state: Sichuan
city: Tianjin
country: China
facility: Local Institution - 010-027
state: Tianjin
city: Hangzhou
country: China
facility: Local Institution - 010-707
state: Zhejiang
city: Hangzhou
country: China
facility: Local Institution - 010-034
state: Zhejiang
city: Hangzhou
country: China
facility: Local Institution - 010-032
city: Hongkou Qu
country: China
facility: Local Institution - 010-033
city: Barranquilla
country: Colombia
facility: Local Institution - 010-460
city: Bogota
country: Colombia
facility: Local Institution - 010-462
city: Floridablanca
country: Colombia
facility: Local Institution - 010-465
city: Medellin
country: Colombia
facility: Local Institution - 010-463
city: Brno
country: Czechia
facility: Local Institution - 010-165
city: Brno
country: Czechia
facility: Local Institution - 010-160
city: Olomouc
country: Czechia
facility: Local Institution - 010-162
city: Praha 5
country: Czechia
facility: Local Institution - 010-161
city: Copenhagen
country: Denmark
facility: Local Institution - 010-171
city: Odense
country: Denmark
facility: Local Institution - 010-172
city: Vejle
country: Denmark
facility: Local Institution - 010-170
city: Helsinki
country: Finland
facility: Local Institution - 010-180
city: Tampere
country: Finland
facility: Local Institution - 010-182
city: Turku
country: Finland
facility: Local Institution - 010-181
city: Chambray-les-Tours
country: France
facility: Local Institution - 010-209-A
state: Centre-Val De Loire
city: Avignon
country: France
facility: Local Institution - 010-668
city: Besancon
country: France
facility: Local Institution - 010-208
city: Bordeaux
country: France
facility: Local Institution - 010-669
city: Brest
country: France
facility: Local Institution - 010-194
city: Dijon cedex
country: France
facility: Local Institution - 010-192
city: Lille
country: France
facility: Local Institution - 010-662
city: Lyon
country: France
facility: Local Institution - 010-205
city: Marseille Cedex 5
country: France
facility: Local Institution - 010-682
city: Paris Cedex 12
country: France
facility: Local Institution - 010-203
city: Paris
country: France
facility: Local Institution - 010-207
city: Paris
country: France
facility: Local Institution - 010-204
city: Paris
country: France
facility: Local Institution - 010-661
city: Pessac
country: France
facility: Local Institution - 010-660
city: Suresnes
country: France
facility: Local Institution - 010-667
city: Toulouse cedex 9
country: France
facility: Local Institution - 010-680
city: Tours Cedex 9
country: France
facility: Local Institution - 010-209
city: Villejuif
country: France
facility: Local Institution - 010-202
city: Amberg
country: Germany
facility: Local Institution - 010-675
city: Berlin
country: Germany
facility: Local Institution - 010-657
city: Bochum
country: Germany
facility: Local Institution - 010-655
city: Dresden
country: Germany
facility: Local Institution - 010-227
city: Frankfurt am Main
country: Germany
facility: Local Institution - 010-229
city: Hamburg
country: Germany
facility: Local Institution - 010-656
city: Herne
country: Germany
facility: Local Institution - 010-658
city: Monchengladbach
country: Germany
facility: Local Institution - 010-228
city: Munchen
country: Germany
facility: Local Institution - 010-650
city: Munchen
country: Germany
facility: Local Institution - 010-226
city: Reutlingen
country: Germany
facility: Local Institution - 010-652
city: Ulm
country: Germany
facility: Local Institution - 010-676
city: Athens
country: Greece
facility: Local Institution - 010-501
city: Cholargos
country: Greece
facility: Local Institution - 010-232
city: Heraklion
country: Greece
facility: Local Institution - 010-238
city: Larissa
country: Greece
facility: Local Institution - 010-235
city: Thessaloniki
country: Greece
facility: Local Institution - 010-231
city: Thessaloniki
country: Greece
facility: Local Institution - 010-230
city: Central
country: Hong Kong
facility: Local Institution - 010-048
city: Hong Kong
country: Hong Kong
facility: Local Institution - 010-046
city: Dublin
country: Ireland
facility: Local Institution - 010-250
city: Dublin
country: Ireland
facility: Local Institution - 010-252
city: Dublin
country: Ireland
facility: Local Institution - 010-253
city: Dublin
country: Ireland
facility: Local Institution - 010-254
city: Dublin
country: Ireland
facility: Local Institution - 010-251
city: Avellino
country: Italy
facility: Local Institution - 010-292
city: Biella
country: Italy
facility: Local Institution - 010-290
city: Cagliari
country: Italy
facility: Local Institution - 010-299
city: Candiolo
country: Italy
facility: Local Institution - 010-286
city: Lido di Camaiore
country: Italy
facility: Local Institution - 010-287
city: Meldola
country: Italy
facility: Local Institution - 010-270
city: Milano
country: Italy
facility: Local Institution - 010-293
city: Milan
country: Italy
facility: Local Institution - 010-278
city: Napoli
country: Italy
facility: Local Institution - 010-271
city: Padova
country: Italy
facility: Local Institution - 010-297
city: Pisa
country: Italy
facility: Local Institution - 010-294
city: Reggio Emilia
country: Italy
facility: Local Institution - 010-291
city: Roma
country: Italy
facility: Local Institution - 010-295
city: Torino
country: Italy
facility: Local Institution - 010-289
city: Anyang-si
country: Korea, Republic of
facility: Local Institution - 010-116
city: Busan
country: Korea, Republic of
facility: Local Institution - 010-111
city: Busan
country: Korea, Republic of
facility: Local Institution - 010-119
city: Daejeon
country: Korea, Republic of
facility: Local Institution - 010-525
city: Goyang-si
country: Korea, Republic of
facility: Local Institution - 010-117
city: Hwasun-gun
country: Korea, Republic of
facility: Local Institution - 010-100
city: Seongnam-si
country: Korea, Republic of
facility: Local Institution - 010-520
city: Seoul
country: Korea, Republic of
facility: Local Institution - 010-105
city: Seoul
country: Korea, Republic of
facility: Local Institution - 010-108
city: Seoul
country: Korea, Republic of
facility: Local Institution - 010-118
city: Seoul
country: Korea, Republic of
facility: Local Institution - 010-104
city: Seoul
country: Korea, Republic of
facility: Local Institution - 010-114
city: Seoul
country: Korea, Republic of
facility: Local Institution - 010-109
city: Suwon-Si
country: Korea, Republic of
facility: Local Institution - 010-115
city: Yangsan-si
country: Korea, Republic of
facility: Local Institution - 010-524
city: Johor Bahru
country: Malaysia
facility: Local Institution - 010-070
state: Johor
city: Kota Kinabalu
country: Malaysia
facility: Local Institution - 010-077
state: Sabah
city: Petaling Jaya
country: Malaysia
facility: Local Institution - 010-071
state: Selangor
city: Kuala Lumpur
country: Malaysia
facility: Local Institution - 010-073
city: Kuala Lumpur
country: Malaysia
facility: Local Institution - 010-074
city: Putrajaya
country: Malaysia
facility: Local Institution - 010-072
city: Tuxtla Gutierrez
country: Mexico
facility: Local Institution - 010-474
state: Chiapas
city: Mexico City
country: Mexico
facility: Local Institution - 010-473
state: Distrito Federal
city: Guadalajara
country: Mexico
facility: Local Institution - 010-472
state: Jalisco
city: Guadalajara
country: Mexico
facility: Local Institution - 010-477
state: Jalisco
city: Cuernavaca
country: Mexico
facility: Local Institution - 010-476
state: Morelos
city: San Juan del Rio
country: Mexico
facility: Local Institution - 010-475
state: Queretaro
city: Colonia Centro Orizaba
country: Mexico
facility: Local Institution - 010-471
state: Veracruz
city: Amsterdam
country: Netherlands
facility: Local Institution - 010-632
city: Amsterdam
country: Netherlands
facility: Local Institution - 010-306
city: Nijmegen
country: Netherlands
facility: Local Institution - 010-630
city: Utrecht
country: Netherlands
facility: Local Institution - 010-307
city: Gdansk
country: Poland
facility: Local Institution - 010-328
city: Otwock
country: Poland
facility: Local Institution - 010-327
city: Warszawa
country: Poland
facility: Local Institution - 010-322
city: Warszawa
country: Poland
facility: Local Institution - 010-787
city: Braga
country: Portugal
facility: Local Institution - 010-332
city: Lisbon
country: Portugal
facility: Local Institution - 010-337
city: Lisbon
country: Portugal
facility: Local Institution - 010-640
city: Porto
country: Portugal
facility: Local Institution - 010-331
city: Porto
country: Portugal
facility: Local Institution - 010-339
city: San Juan
country: Puerto Rico
facility: Local Institution - 010-902
city: San Juan
country: Puerto Rico
facility: Local Institution - 010-903
city: San Juan
country: Puerto Rico
facility: Local Institution - 010-900
city: Baia Mare
country: Romania
facility: Local Institution - 010-347
city: Brasov
country: Romania
facility: Local Institution - 010-349
city: Bucharest
country: Romania
facility: Local Institution - 010-512
city: Cluj-Napoca
country: Romania
facility: Local Institution - 010-344
city: Cluj-Napoca
country: Romania
facility: Local Institution - 010-340
city: Craiova
country: Romania
facility: Local Institution - 010-343
city: Ovidiu
country: Romania
facility: Local Institution - 010-511
city: Timisoara
country: Romania
facility: Local Institution - 010-510
city: Singapore
country: Singapore
facility: Local Institution - 010-090
city: Singapore
country: Singapore
facility: Local Institution - 010-093
city: Singapore
country: Singapore
facility: Local Institution - 010-095
city: Singapore
country: Singapore
facility: Local Institution - 010-092
city: Singapore
country: Singapore
facility: Local Institution - 010-091
city: A Coruna
country: Spain
facility: Local Institution - 010-613
city: Badalona
country: Spain
facility: Local Institution - 010-610
city: Barcelona
country: Spain
facility: Local Institution - 010-612
city: Barcelona
country: Spain
facility: Local Institution - 010-600
city: Cordoba
country: Spain
facility: Local Institution - 010-621
city: LHospitalet de Llobregat
country: Spain
facility: Local Institution - 010-620
city: Madrid
country: Spain
facility: Local Institution - 010-619
city: Madrid
country: Spain
facility: Local Institution - 010-601
city: Madrid
country: Spain
facility: Local Institution - 010-617
city: Madrid
country: Spain
facility: Local Institution - 010-624
city: Pamplona
country: Spain
facility: Local Institution - 010-623
city: Sabadell
country: Spain
facility: Local Institution - 010-622
city: Santander
country: Spain
facility: Local Institution - 010-604
city: Valencia
country: Spain
facility: Local Institution - 010-618
city: Valencia
country: Spain
facility: Local Institution - 010-625
city: Changhua City
country: Taiwan
facility: Local Institution - 010-129
city: Kaohsiung
country: Taiwan
facility: Local Institution - 010-121
city: Taichung
country: Taiwan
facility: Local Institution - 010-124
city: Tainan City
country: Taiwan
facility: Local Institution - 010-123
city: Tainan
country: Taiwan
facility: Local Institution - 010-122
city: Taipei City
country: Taiwan
facility: Local Institution - 010-120
city: Taoyuan
country: Taiwan
facility: Local Institution - 010-125
city: Bang Phlat
country: Thailand
facility: Local Institution - 010-132
city: Bangkok
country: Thailand
facility: Local Institution - 010-134
city: Chiang Mai
country: Thailand
facility: Local Institution - 010-131
city: Hat Yai
country: Thailand
facility: Local Institution - 010-130
city: Khlong Toey
country: Thailand
facility: Local Institution - 010-133
city: Sumy
country: Ukraine
facility: Local Institution - 010-424
city: Aberdeen
country: United Kingdom
facility: Local Institution - 010-412
city: Birmingham
country: United Kingdom
facility: Local Institution - 010-410
city: Cambridge
country: United Kingdom
facility: Local Institution - 010-413
city: Dorset
country: United Kingdom
facility: Local Institution - 010-411
city: Glasgow
country: United Kingdom
facility: Local Institution - 010-400
city: Kent
country: United Kingdom
facility: Local Institution - 010-403
city: Leeds
country: United Kingdom
facility: Local Institution - 010-414
city: London
country: United Kingdom
facility: Local Institution - 010-402
city: London
country: United Kingdom
facility: Local Institution - 010-405
city: London
country: United Kingdom
facility: Local Institution - 010-406
city: Manchester
country: United Kingdom
facility: Local Institution - 010-407
city: Middlesex
country: United Kingdom
facility: Local Institution - 010-404
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References: