Clinical trial NCT03847363: The Influence of Different Anesthesia on Acute and Chronic Postsurgical Pain After Thoracic Surgery
Official title: The Influence of Different Anesthesia and Postoperative Pain Management on Acute and Chronic Postsurgical Pain After Thoracic Surgery: a Prospective Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Pain
Chronic Postsurgical Pain
Lead sponsor: Shanghai Zhongshan Hospital
Sponsor class: OTHER
First posted: 2019-02-20
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients underwent selective thoracic surgery meeting inclusion and exclusion criteria

Brief summary: This study would compare acute and chronic postsurgical pain in patients underwent thoracic surgery with different anesthesia and analgesia methods, and explore the influencing factors.

Detailed description: Chronic postsurgical pain (CPSP) was the pain caused by the operation that exceeded the healing time of normal tissue (usually 3 months), that was, a status that the damage caused by noxious stimulus had been healed, but the pain that cannot be explained by disease and inflammation were still existed. Due to the location of the incision and the necessity of indwelling the chest tube, the thoracic lung surgery was considered to be one of the most painful surgical operations. Studies have found that the incidences of CPSP in patients with thoracotomy were 57% (95% CI, 51-64%) and 47% (95% CI, 39-56%) at postoperative 3 and 6 months, respectively. With the development of minimally invasive techniques, thoracic surgery had gradually become less traumatic, and the number of surgical incisions was gradually developed into single port.Through ages, epidural analgesia with a combination of local anesthetics and opioids had long been considered the "gold standard" for postoperative analgesia in thoracic surgery. However, with the development of clinical anesthetics and the widespread use of nerve block techniques, it had been found that in open radical gastrectomy, there was no significant difference in the inhibition of intraoperative stress response between dexmedetomidine combined with general anesthesia and a combined general-epidural anesthesia. So, which anesthesia and analgesia method was "perfect" for a specific type of surgery procedure? This study would compare acute and chronic postsurgical pain in patients underwent different thoracic surgery procedure with different anesthesia and analgesia methods, and explore the influencing factors.

Eligibility criteria: Inclusion Criteria:

* ASA I-II
* underwent selective thoracic surgery

Exclusion Criteria:

* with severe cardiac, endocrine,immunologic or haematologic diseases
* medical history of chronic pain problems in chest area
* medical history of pain-relief or sedative medication
* not able to communicate with investigators

Primary outcomes:
measure: numerical rating scale of acute postsurgical pain
timeFrame: at day1 post-operation
measure: numerical rating scale of acute postsurgical pain
timeFrame: at day2 post-operation
measure: numerical rating scale of chronic postsurgical pain
timeFrame: at 3rd month post-operation
measure: numerical rating scale of chronic postsurgical pain
timeFrame: at 6th month post-operation
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Zhongshan Hospital, Fudan University
state: Shanghai
Study officials:
affiliation: Shanghai Zhongshan Hospital
name: jing cang
role: STUDY_CHAIR
References: