Clinical trial NCT01275963: New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function
Official title: New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Pathology
Keywords: Echocardiography
Strain imaging
Ventricular Dysfunction
Cardiomyopathy
Longitudinal left ventricular function
Lead sponsor: Heidelberg University
Sponsor class: OTHER
First posted: 2011-01-13
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy individuals and patients with various cardiac pathologies, who undergo routine echocardiography at our department

Brief summary: Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components.

The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.


Eligibility criteria: Inclusion Criteria:

* persons of 18 years and older who receive a transthoracic echocardiography at our department
* written consent

Exclusion Criteria:

* permanent pacemaker rhythm
* moderate/severe valvular heart disease

Primary outcomes:
measure: left ventricular longitudinal systolic strain (LV-LSS) in all patients
timeFrame: 2 years
Secondary outcomes:
measure: mitral annular plane systolic excursion (MAPSE) in all patients
timeFrame: 2 years
measure: mitral annular systolic velocity (MASV) in all patients
timeFrame: 2 years
measure: diastolic left ventricular function in all patients
timeFrame: 2 years
measure: pulmonary artery systolic pressure (PASP) in all patients
timeFrame: 2 years
measure: left ventricular ejection fraction (LVEF) in all patients
timeFrame: 2 years
Other outcomes:
Locations:
city: Heidelberg
country: Germany
facility: University of Heidelberg
Study officials:
affiliation: Heidelberg University
name: Matthias Aurich, M.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Heidelberg University
name: Derliz Mereles, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Aurich M, Keller M, Greiner S, Steen H, Aus dem Siepen F, Riffel J, Katus HA, Buss SJ, Mereles D. Left ventricular mechanics assessed by two-dimensional echocardiography and cardiac magnetic resonance imaging: comparison of high-resolution speckle tracking and feature tracking. Eur Heart J Cardiovasc Imaging. 2016 Dec;17(12):1370-1378. doi: 10.1093/ehjci/jew042. Epub 2016 Mar 24.