Clinical trial NCT05054686: The Effect of Exercise Combination on Pain, Function and Proprioception in Knee Osteoarthritis
Official title: The Effect of Exercise Combination in Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Osteoarthritis
Keywords: ostearthritis
stretching
strengthening
aerobic exercises
Lead sponsor: Istanbul University - Cerrahpasa
Sponsor class: OTHER
First posted: 2021-09-23
Enrollment: 45
Sex: ALL
Minimum age (years): 45
Maximum age (years): 73
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Prospective Parallel Group Comparison Study
Primary purpose: TREATMENT

Brief summary: This study will include 3 different groups of intervention. First group of knee osteoarthritis patients will be applied both strengthening and 30 minutes bicycle exercises in the same session, 2 days strecthing exercises and 30 minutes walking will be given in seperate days as home program, Second group of knee osteoarthritis patients will be applied both stretching and 30 minutes bicycle exercises in the same session, strengthening exercises and 30 minutes walking will be given in seperate days as home program.Third group of knee osteoarthritis patients will be applied all stretching, strengthening and 30 minutes bicycle exercises in the same session, only 30 minutes walking will be given as home program. The primary outcome measures include the pain, function and the secondary outcome measures include the joint proprioception. The aim of this study is to investigate the effects on outcome measures increasing number of exercises in one session and to determine which exercise types are more suitable to prescribe as a home program.

Detailed description: This study will include 3 different groups of intervention. First group of knee osteoarthritis patients will be applied both strengthening and bicycle exercises in the same session and strecthing exercises and walking will be given as home program in the days other than treatment session. Second group of knee osteoarthritis patients will be applied both stretching and bicycle exercises in the same session and strengthening exercises and walking will be given as home program in the days other than treatment session. Third group of knee osteoarthritis patients will be applied all stretching, strengthening and bicycle exercises in the same session and only walking exercise will be given as home program in the days other than treatment session. The primary outcome measures include the pain, function and the secondary outcome measures include the joint proprioception and aerobic capacity. The aim of this study is to investigate the effects increasing number of exercises in one session on outcome measures consisting of pain, function and proprioception. The pain will be evaluated both subjectively with numeric pain scale and WOMAC scale and objectively with pressure algometer. The function will be subjectively evaluated with WOMAC scale and objectively by measuring the knee joint range of motion and muscle strength for both flexor and extensor muscles. The evaluation of joint proprioception will be evaluated with inclinometer. The aerobic capacity will be objectively evaluated with 6 minute walk test. All the groups will be treated 2 days per week. The duration of total treatment lasts 8 weeks. All the groups practice aerobic exercises 2 days with bicycle ergometer application in the clinic, and 2 days walking outside as home program. Strecthing exercises will be applied for knee flexor and knee extensor muscles. Isometric strengthening exercises will be applied for knee extensor muscles. Isotonic strengthening exercises will be applied for hip abductor muscles, hip extensor muscles, hip flexor muscles, knee flexor muscles and knee extensor muscles. The treatment outcomes will be evaluated both at the beginning of treatment and at the end of treatment.

Eligibility criteria: Inclusion Criteria:

* Being diagnosed as knee osteoarthritis
* Being between the ages 45-74
* Being at stage 2-3 according to Kellegren Lawrence Classification
* Having body mass index lower than 30
* Being volunteer for participation to this study

Exclusion Criteria:

* Refusing to participation to study
* Having another orthopeadic problem ralated to lower extremity
* Having uncontrollable hypertension
* Having arterial and venous disease
* Having neurological disease
* Having perceptual problem
* Having cardiac pacemaker
* Participation to physiotherapy program in the last 6 months for the same extremity
* Taking injection from the same extremity in the last 6 months

Primary outcomes:
measure: The Western Ontario and McMaster Universities Arthritis Index
timeFrame: Change of The Western Ontario and McMaster Universities Arthritis Index scores from the beginning to the end of study (8 weeks)
measure: Numeric Pain Rating Scale
timeFrame: Change of Numeric Pain Rating Scale scores from the beginning to the end of study (8 weeks)
measure: Pain Pressure Treshold (PPT)
timeFrame: Change of Pain Pressure Treshold measurements from the beginning to the end of study (8 weeks)
measure: Range of Motion at knee joint both in flexion and extension
timeFrame: Change of Range of Motion measurements from the beginning to the end of study (8 weeks)
measure: Muscle strength for knee flexor and extensor muscles
timeFrame: Change of muscle strength measurements from the beginning to the end of study (8 weeks)
Secondary outcomes:
measure: Proprioception
timeFrame: Change of Inclinometric measurements from the beginning to the end of study (8 weeks).
measure: Aerobic Capacity
timeFrame: Change of 6 Minute Walk Test from the beginning to the end of study (8 weeks)
Other outcomes:
Locations:
city: Küçükçekmece
country: Turkey
facility: Seda Baktır
state: Alkent 2000, Büyükçekmece/İstanbul
Study officials:
affiliation: Istanbul University - Cerrahpasa
name: Seda BAKTIR, MSc.PT.
role: PRINCIPAL_INVESTIGATOR
References: