Clinical trial NCT05776589: The Effect of Intraoperative Ventilation Mode on Hemodynamics and Lung Dynamics
Official title: The Effect of Pressure Controlled Volume Guaranteed Ventilation and Volume Controlled Ventilation on Hemodynamics and Lung Dynamics in Prone Position Patients in Thoracolomber Vertebra Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Mechanical Ventilation
Keywords: lung dynamics under general anesthesia
prone position
pressure controlled mode
volume controlled mode
vertabral surgery
Lead sponsor: Izmir Ataturk Training and Research Hospital
Sponsor class: OTHER
First posted: 2023-03-20
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients undergoing vertebral surgery in the prone position.

Brief summary: In this study, it was aimed to compare the effects of pressure-controlled volume-guaranteed ventilation (PCV-VG) and volume-controlled ventilation (VCV) on lung dynamics and hemodynamics in patients undergoing vertebral surgery in the prone position.

Detailed description: The VCV (volume controlled ventilation) mode is the mode commonly used in general anesthesia practice. In VCV mode, the parameters under control are tidal volume and respiratory rate. In VCV mode, airway pressure changes depending on resistance and compliance. There is a risk of increased airway pressures in this mode.

In PCV-VG (pressure controlled volume guaranteed ventilation) mode, the parameters under control are the peak airway inspiratory pressure and the I/E ratio. It has been shown that peak airway pressures decrease and partial oxygen pressure increase due to decreased inspiratory flow in this ventilation mode.

Both ventilation modes are frequently used in patients undergoing general anesthesia.

In this study, it was aimed to compare the effects of pressure-controlled volume-guaranteed ventilation (PCV-VG) and volume-controlled ventilation (VCV) on lung dynamics (pulmonary peak-plateau pressure, compliance, driving pressure, SpO2 and end-tidal carbon dioxide) and hemodynamics (mean arterial pressure and heart rate) in patients undergoing vertebral surgery in the prone position.

In the study, patients will be randomized and divided into 2 groups after obtaining informed consent forms. If a mode change is required during the surgery, that patient will be excluded from the study.

Eligibility criteria: Inclusion Criteria:

* Patients who will undergo thoracolumbar vertebral surgery in the prone position
* Patients older than 18 years
* Patients younger than 70 years of age
* ASA 1-2 patients

Exclusion Criteria:

* Patients with a BMI \>30 kg/m2
* Patients with a history of chronic pulmonary disease
* Patients with a history of previous thoracic surgery
* Patients with ASA \>3
* Patients who will undergo emergency surgery
* Pregnant patients

Primary outcomes:
measure: Comparison of the effects of pressure controlled volume guaranteed ventilation and volume controlled ventilation on lung compliance
timeFrame: 3 months
Secondary outcomes:
measure: Comparison of the effects of pressure controlled volume guaranteed ventilation and volume controlled ventilation on heart rate
timeFrame: 3 months
measure: Comparison of the effects of pressure-controlled volume guaranteed ventilation and volume-controlled ventilation on mean arterial pressure
timeFrame: 3 months
Other outcomes:
Locations:
city: Izmir
country: Turkey
facility: KCU Izmir Atatürk Training and Research Hospital
Study officials:
affiliation: Izmir Atatürk Training and Reseach Hospital
name: Derya A Yurtlu, M.D.
role: PRINCIPAL_INVESTIGATOR
References: