Clinical trial NCT05930912: Psychiatric Orders in Psychoanalytic Treatment of ASD
Official title: Psychiatric Orders in Psychoanalytic Treatment of ASD
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: PTSD
Autism Spectrum Disorder High-Functioning
OCD
Agoraphobia With Panic Attacks
Depression, Unipolar
Depression, Anxiety
Depression and Suicide
Depression, Reactive
Depression; Psychoneurotic
Depression Anxiety Disorder
Panic Disorder With Agoraphobia, Severe Agoraphobic Avoidance and Mild Panic Attacks
Anxiety Disorders
ADHD - Combined Type
Borderline Personality Disorder
Social Anxiety Disorder
Avoidant Personality Disorder
Stockholm Syndrome
Grief
Separation Insecurity
Lead sponsor: Pachankis, Yang I., M.D.
Sponsor class: INDIV
Collaborators: name: S for Science
First posted: 2023-07-05
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population is currently Asian, and the sociostructural environment of People's Republic of China is implied.

Brief summary: Autism Spectrum Disorder (ASD) is often accompanied by a variety of other symptoms, such as bipolar disorder, Attention Deficit Hyperactivity Disorder (ADHD), Social Anxiety Disorder (SAD), Avoidant Personality Disorder (AvPD), Obsessive Compulsive Disorder (OCD), etc. The behavioral and social complications often marginalize the population, impact on life satisfaction, undermined societal values that impact on economic and financial fairness, and so forth. Furthermore, persons with ASD are neurodiverse from standardized pharmacological and clinical cares, and are interpreted disadvantaged in the context of neurotypical treatments.

The research protocol aims to differentiate the neuropharmacological implications of ASD from its behavioral and social implications. Such a differentiation is beneficial to the quality of care for neurodiverse population, both in terms of precision treatment in medical settings, and in terms of psychotherapeutic treatment efficacy in the interpretation of behavioral and social traits.

The study protocol continues from the adverse event of the participant in NCT05711810 trial, after the positive immunological results in the NCT05839236 trial. The intervention medicine continues from Sertraline adjusted on the choice of Selective Serotonin Reuptake Inhibitor (SSRI) in the previous two trials for complex post-traumatic stress disorder (CPTSD) of the participant, and its combined used with Duloxetine in the choice of Selective Norephedrine Reuptake Inhibitor (SNRI) for norephedrine regulations.

The hypothesized target is on the discrete psychiatric intervention centered approach to ASD treatment care. In the PRC where the study is being carried out, amphetamine class medicines are strictly prohibited and defined as illegal substances, regardless of their only proven effect for ASD patient care. Contributed by the sociostructural elements and necessities, black market amphetamine and ketamine have not only emerged in the regime for decades, but also have become a lucrative business. Their recreational uses are also sometimes accompanied by real necessities and needs; black markets cater to the needs but guidance on the usages is based on word-of-mouth stories without professional medical assistances. There is one case the Principal Investigator (PI) collected, that one person, possibly under depression contributed by PTSD, took relatively high dosage of amphetamine and went into a state of psychosis with overwhelming persecution mania. The study protocol, Psychiatric Orders in Psychoanalytic Treatment of ASD, is therefore designed for an evidence-based approach in treating complex psychiatric disorders with psychoanalytic guidance.


Eligibility criteria: Inclusion Criteria:

* Persons with ASD.

Exclusion Criteria:

* Severe ASD cases with central nerve system complications.

Primary outcomes:
measure: Hamilton Anxiety Rating Scale (HAM-A)
timeFrame: 90 days
measure: Generalized Anxiety Disorder (GAD-7)
timeFrame: 90 days
measure: Dissociative Experiences Scale - II (DES-II)
timeFrame: 90 days
measure: The Defeat Scale (D Scale)
timeFrame: 90 days
measure: Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
timeFrame: 90 days
measure: Severity Measure for Agoraphobia-Adult
timeFrame: 90 days
measure: BPD Check List
timeFrame: 90 days
measure: Rosenberg Self-Esteem Scale (RSE)
timeFrame: 90 days
measure: Young Schema Questionnaire (YSQ)
timeFrame: 90 days
measure: Personality Belief Questionnaire (PBQ)
timeFrame: 90 days
measure: Behavioral Satisfaction Questionnaire (X axis)
timeFrame: 90 days
measure: Behavioral Satisfaction Questionnaire (Y axis)
timeFrame: 90 days
Secondary outcomes:
measure: Heart Rate
timeFrame: 90 days
measure: Systolic Blood Pressure
timeFrame: 90 days
measure: Diastolic Blood Pressure
timeFrame: 90 days
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Residential Address
state: Chongqing
Study officials:
References:
citation: Yang IP. Questions of COVID-19: Institutional Derogations of Global Health. Lambert Academic Publishing. 2023. ISBN: 978-6206153849.
citation: Pachankis Y. Jeopardies in human security and politicization of COVID-19. Ethics Med Public Health. 2023 Apr;27:100871. doi: 10.1016/j.jemep.2023.100871. Epub 2023 Feb 1. No abstract available.
citation: Yang IP. Dictatorial Psychopathological Commination in Server-Side Public Mental & Psychological Menace. Biomedical Science and Clinical Research. 2023; 2(2): 173-184.
citation: Yang IP. Proton Paths of Cardiac Immune Reflex. Online Journal of Cardiology Research & Reports. 2023; 7(1): 000655.
citation: Yang IP. What Do We Need in Adolescence?. Journal of Addiction Research. 2023; 7(1): 7-8.
citation: Yang IP. Proton Decay Reconstruction in Conscious Phenomenon - Literature Review on MRI, EEG, and PET Technologies. Advances in Sexual & Reproductive Health Research. 2022; 1(1): 128-130.
citation: Yang IP. Correlating Nuclear Sciences to Biochemistry - Mini-review on the Environmental Physiological Impact of Electronic Warfare on Public Health. Journal of Clinical Chemistry. 2022; 1(2): 1-5.
citation: Yang IP. Mass Surveillance, Behavioural Control, and Psychological Coercion - The Moral Ethical Risks in Commercial Devices. In: Wyld, D. C. & Nagamalai, D. (Eds.) Computer Science and Information Technology. 2022; 151-168. AIRCC Publishing Corporation.
citation: Yang IP. Technical Analysis on the Cyber Organizational Criminology of Dictatorial Military Conducts -- Experience from Human Trafficking and Coercions by Military Cyber Aggressions. International Journal of Security, Privacy and Trust Management. 2022; 11(3): 1-19.
citation: Yang IP. The Cultural Revisionist Element behind P. R. China's Neo-Nazism: A Cross-cultural and Cross-religion Research. International Journal of Advanced Multidisciplinary Research and Studies. 2022; 2(4): 435-451.
citation: Yang IP. A Self--help Guide to Psychoanalysis in Cisgender Homosexual Male. Journal of Marketing Management and Consumer Behavior. 2022; 4(2), 93-110.
citation: Yang IP. An Evidence-driven Research to the Transgressions of Geneva Conventions by the Communist Party of China Led Autocratic Regime. International Journal of Scientific & Engineering Research. 2022; 13(10): 249-266.
citation: Yang IP. Targeted Human Trafficking - The Wars between Proxy and Surrogated Economy. International Journal of Scientific & Engineering Research. 2022; 13(7): 398-409.
citation: Yang IP. Why Should LGBTQI Marriage Be Legalized. Academia Letters. 2022; Article 5157.