Clinical trial NCT03134781: Hybrid Exercise Training for Weight Loss
Official title: The Effects of a Novel Hybrid Exercise Training Program on Body Composition, Body Weight and Energy Balance in Sedentary Overweight/Obese Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Circuit-based High Intensity Interval Training
Body Composition
Resting Metabolic Rate
Habitual Physical Activity
Performance
Lead sponsor: University of Thessaly
Sponsor class: OTHER
First posted: 2017-05-01
Enrollment: 49
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: In this study the investigators utilized a novel hybrid HIIT (high intensity interval training) exercise training approach, the Hybrid Interval Training (DoIT) workout that combines interval training, resistance exercise training and functional training in order to test the hypothesis that DoIT will be able to: i) reduce body mass, ii) improve body composition and iii) alter energy balance, of previously inactive, overweight/obese women.

Detailed description: In a controlled randomized, two-group, repeated measures design, 65 healthy, sedentary, premenopausal overweight or obese women were randomly assigned to one of three groups: (a) a control group (C, N=21) that participated only in measurements, (b) a training group (TR, N=14) that participated in a supervised 40-week DoIT workout exercise training program and (c) a training-detraining group (TRD, N=14). During the first 20 weeks, TR and TRD followed exactly the same training protocol. At the end of this period, TR continued training for 20 more weeks whereas TRD terminated training for 20 weeks (detraining). Anthropometric, metabolic, daily nutritional intake, habitual physical activity and performance measurements were performed in all groups at baseline, at 20 weeks and 40 weeks.

Eligibility criteria: Inclusion Criteria:

* (a) were sedentary (\<7,500 steps/day; VO2max \<30 ml/kg/min), b) premenopausal women aged 30-45 years, c) were overweight or obese class 1 (BMI=25-34.9 kg/m2), d) were non-smokers for ≥6 months before the study, e) not following a diet intervention or using nutritional supplements/medications before (≥6 months) and during the study, f) had no weight loss greater \>10% of body mass ≤6 months before the study, g) participated in ≥80% of total exercise sessions, and h) had no symptoms of depression.

Exclusion Criteria:

* a) a recent febrile illness, b) history of muscle lesion, c) lower limb trauma, d) signs, symptoms or diagnosis of serious health complications or physical disability or other medical condition compromising safe participation in exercise training.

Primary outcomes:
measure: Change in body mass
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in body mass index
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in waist circumference
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in hip circumference
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in waist-to-hip ratio
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in body fat.
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in fat mass
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in fat-free mass
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in resting metabolic rate
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in exercise-induced caloric expenditure.
timeFrame: At baseline, at 20 weeks and at 40 weeks.
Secondary outcomes:
measure: Change in maximal strength (1RM)
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in maximal oxygen consumption (VO2max)
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in blood lactate concentration
timeFrame: Pre-exercise, during the exercise and post-exercise at baseline, at 20 weeks and at 40 weeks.
measure: Change in habitual physical activity
timeFrame: At baseline, at 20 weeks and at 40 weeks.
measure: Change in dietary intake
timeFrame: At baseline, at 20 weeks and at 40 weeks.
Other outcomes:
Locations:
city: Trikala
country: Greece
facility: Exercise Biochemistry Laboratory, School of Physical Education & Sports Sciences, University of Thessaly
state: Karies
Study officials:
References:
citation: Batrakoulis A, Jamurtas AZ, Georgakouli K, Draganidis D, Deli CK, Papanikolaou K, Avloniti A, Chatzinikolaou A, Leontsini D, Tsimeas P, Comoutos N, Bouglas V, Michalopoulou M, Fatouros IG. High intensity, circuit-type integrated neuromuscular training alters energy balance and reduces body mass and fat in obese women: A 10-month training-detraining randomized controlled trial. PLoS One. 2018 Aug 23;13(8):e0202390. doi: 10.1371/journal.pone.0202390. eCollection 2018.
citation: Batrakoulis A, Loules G, Georgakouli K, Tsimeas P, Draganidis D, Chatzinikolaou A, Papanikolaou K, Deli CK, Syrou N, Comoutos N, Theodorakis Y, Jamurtas AZ, Fatouros IG. High-intensity interval neuromuscular training promotes exercise behavioral regulation, adherence and weight loss in inactive obese women. Eur J Sport Sci. 2020 Jul;20(6):783-792. doi: 10.1080/17461391.2019.1663270. Epub 2019 Sep 16.
citation: Batrakoulis A, Tsimeas P, Deli CK, Vlachopoulos D, Ubago-Guisado E, Poulios A, Chatzinikolaou A, Draganidis D, Papanikolaou K, Georgakouli K, Batsilas D, Gracia-Marco L, Jamurtas AZ, Fatouros I. Hybrid neuromuscular training promotes musculoskeletal adaptations in inactive overweight and obese women: A training-detraining randomized controlled trial. J Sports Sci. 2021 Mar;39(5):503-512. doi: 10.1080/02640414.2020.1830543. Epub 2020 Oct 15.
citation: Batrakoulis A, Jamurtas AZ, Draganidis D, Georgakouli K, Tsimeas P, Poulios A, Syrou N, Deli CK, Papanikolaou K, Tournis S, Fatouros IG. Hybrid Neuromuscular Training Improves Cardiometabolic Health and Alters Redox Status in Inactive Overweight and Obese Women: A Randomized Controlled Trial. Antioxidants (Basel). 2021 Oct 12;10(10):1601. doi: 10.3390/antiox10101601.
citation: 2020 NSCA Research Abstracts. J Strength Cond Res. 2021 Apr 1;35(4):e3-e288. doi: 10.1519/JSC.0000000000003877. No abstract available.