Clinical trial NCT06832358: Positive Psychological Intervention for Parkinson's Disease Patients
Official title: Effect Evaluation of PERMA Positive Psychological Intervention Model in Parkinson's Disease Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson
Lead sponsor: First Affiliated Hospital of Wenzhou Medical University
Sponsor class: OTHER
First posted: 2025-02-18
Enrollment: 60
Sex: ALL
Minimum age (years): 42
Maximum age (years): 81
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to evaluate the impact of positive psychological intervention based on the PERMA model on Parkinson's disease patients by assessing their depression, quality of life, and related psychological indicators before and after intervention.


Eligibility criteria: Inclusion Criteria:

* Subjects must meet the clinical diagnostic criteria for primary Parkinson's disease
* Subjects must not have a history of depression or other significant illnesses (e.g., stroke, coronary heart and tumor disease)
* Subjects should have clear consciousness, effective communication capabilities, and basic comprehension and reading skills to complete routine assessments
* The diagnosis of depression adhered to the ' Chinese Classification and Diagnostic Criteria for Mental Disorders ' (Revised Third Edition)
* Subjectsshould not have schizophrenia
* Subjects should not have substance abuse (alcohol, tobacco or other psychoactive substances)

Exclusion Criteria:

* Subjects with significant mental or cognitive impairment that communication or completion of scale assessments
* Subjects exhibiting severe self-harm or suicidal tendencies
* Subjects with severe dysfunction of the heart, liver, kidney or other critical organs
* Subjects with contraindications for transcranial magnetic stimulation (such as cochlear implant, pacemaker, built-in pump, artificial metal heart valve, suspected metal in the eye or elevated intracranial pressure)
* Subjects with a history of epilepsy that is poorly controlled
* Subjects with Parkinson's disease who have undergone surgical treatment

Primary outcomes:
measure: the scores of Unified Parkinson's Disease Rating Scale(UPDRS)
timeFrame: before the intervention
measure: the scores of Unified Parkinson's Disease Rating Scale(UPDRS)
timeFrame: after one month of intervention
measure: the scores of Parkinson's Disease Quality of Life Scale(PDQ-39)
timeFrame: before the intervention
measure: the scores of Parkinson's Disease Quality of Life Scale(PDQ-39)
timeFrame: after one month of intervention
measure: the scores of Hamilton Depression Scale(HAMD)
timeFrame: before the intervention
measure: the scores of Hamilton Depression Scale(HAMD)
timeFrame: after one month of intervention
measure: the scores of Hamilton Anxiety Scale(HAMA)
timeFrame: before the intervention
measure: the scores of Hamilton Anxiety Scale(HAMA)
timeFrame: after one month of intervention
measure: the scores of Connor-Davidson Resilience Scale(CD-RISC)
timeFrame: before the intervention
measure: the scores of Connor-Davidson Resilience Scale(CD-RISC)
timeFrame: after one month of intervention
measure: the scores of Pittsburgh Sleep Quality Index(PSQI)
timeFrame: before the intervention
measure: the scores of Pittsburgh Sleep Quality Index(PSQI)
timeFrame: after one month of intervention
measure: the scores of Mini-Mental State Examination(MMSE)
timeFrame: before the intervention
measure: the scores of Mini-Mental State Examination(MMSE)
timeFrame: after one month of intervention
measure: the scores of Positive and Negative Affect Schedule (PANAS)
timeFrame: before the intervention
measure: the scores of Positive and Negative Affect Schedule (PANAS)
timeFrame: after one month of intervention
measure: the Newcastle Nursing Satisfaction Scale score
timeFrame: before the intervention
measure: the Newcastle Nursing Satisfaction Scale score
timeFrame: after one month of intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University
Study officials:
References: