Clinical trial NCT01043640: Allogeneic Bone Marrow Transplant for Inherited Metabolic Disorders
Official title: Allogeneic Hematopoietic Stem Cell Transplantation for Standard Risk Inherited Metabolic Disorders
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Mucopolysaccharidosis
Hurler Syndrome
Hunter Syndrome
Maroteaux-Lamy Syndrome
Sly Syndrome
Alpha Mannosidosis
Fucosidosis
Aspartylglucosaminuria
Adrenoleukodystrophy (ALD)
Krabbe Disease
Metachromatic Leukodystrophy (MLD)
Sphingolipidoses
Peroxisomal Disorders
Keywords: inherited metabolic disorders
Lead sponsor: Masonic Cancer Center, University of Minnesota
Sponsor class: OTHER
First posted: 2010-01-07
Enrollment: 46
Sex: ALL
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Rationale: Chemotherapy administration before a donor stem cell transplant is necessary to stop the patient's immune system from rejecting the donor's stem cells. When healthy stem cells from a donor are infused into the patient, the donor white blood cells can provide the missing enzyme that causes the metabolic disease. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving a monoclonal antibody, alemtuzumab, before transplant and cyclosporine and mycophenolate mofetil before and after transplant may stop this from happening. This may be an effective treatment for inherited metabolic disorders.

Purpose: The design of this study is to achieve donor cell engraftment in patients with standard-risk inherited metabolic diseases with limited peri-transplant morbidity and mortality. This will be achieved through the administration of the chemotherapy regimen described. The intention is to follow transplanted patient for years after transplant monitoring them for complications of their disease and assisting families with a multifaceted interdisciplinary approach.

Detailed description: Primary Objective:

* To estimate the proportion of patients with donor derived engraftment at day 100 post transplant as defined by 80% or greater donor cells in the CD3 (T cell) fraction

Secondary Objectives:

* To determine the incidence and severity of graft-versus-host disease (GVHD) by day 100
* To determine the incidence of peri-transplant mortality (death by day 100)
* To monitor donor cell chimerism at various time points following allogeneic transplantation with this transplant regimen as determined at day 28, 42, 100, 6 months and yearly for 5 years.

Eligibility criteria: Inclusion Criteria:

* Must have diagnosis of one of the following: mucopolysaccharidosis disorder, glycoprotein metabolic disorder, sphingolipidoses or inherited leukodystrophy, peroxisomal disorder or other inherited diseases of metabolism
* Must have an acceptable graft source as defined by University of Minnesota criteria
* Adequate organ function

Exclusion Criteria:

* Pregnant - menstruating females must have a negative serum pregnancy test within 14 days of treatment start
* Evidence of human immunodeficiency virus (HIV) infection or known HIV positive serology

Primary outcomes:
measure: Number of Patients With Donor Derived Engraftment
timeFrame: Day 100 Post Transplant
Secondary outcomes:
measure: Number of Patients With Grade 0 Graft-Versus-Host Disease (GVHD)
timeFrame: Day 100 Post Transplant
measure: Number of Patients With Grade 1 Graft-Versus-Host Disease (GVHD)
timeFrame: Day 100 Post Transplant
measure: Number of Patients With Grade 2 Graft-Versus-Host Disease (GVHD)
timeFrame: Day 100 Post Transplant
measure: Number of Patients With Grade 3 Graft-Versus-Host Disease (GVHD)
timeFrame: Day 100 Post Transplant
measure: Number of Patients With Grade 4 Graft-Versus-Host Disease (GVHD)
timeFrame: Day 100 Post Transplant
measure: Number of Patients Who Died Peri-Transplant
timeFrame: By Day 100 Post Transplant
measure: Donor Cell Chimerism Following Transplant
timeFrame: Day 28
measure: Donor Cell Chimerism Following Transplant
timeFrame: Day 42
measure: Donor Cell Chimerism Following Transplant
timeFrame: Day 100
measure: Donor Cell Chimerism Following Transplant
timeFrame: 6 months
measure: Donor Cell Chimerism Following Transplant
timeFrame: One year
Other outcomes:
Locations:
city: Minneapolis
country: United States
facility: Masonic Cancer Center, University of Minnesota
state: Minnesota
Study officials:
affiliation: Masonic Cancer Center, University of Minnesota
name: Paul Orchard, MD
role: PRINCIPAL_INVESTIGATOR
References: