Clinical trial NCT05535946: ABTECT - Maintenance
Official title: A Randomized, Double-blind, Multicenter Phase III Study to Evaluate the Long-term Efficacy and Safety of ABX464 25 mg or 50 mg Once Daily as a Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Ulcerative Colitis
Lead sponsor: Abivax S.A.
Sponsor class: INDUSTRY
First posted: 2022-09-10
Enrollment: 1050
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Among both induction studies, subjects assessed as responders will be randomized as follows into Part 1 of the maintenance study according to their induction treatment:

* ABX464 Dose 50 mg QD
* ABX464 Dose 25 mg QD
* Placebo. All subjects with clinical response who were dosed with placebo in the induction studies will be randomized into the placebo group.

Among both induction studies, subjects assessed as non-responders will be randomized as follows into Part 2 of the maintenance study according to their induction treatment:

* ABX464 Dose 50 mg QD (all subjects who received 50 mg in induction)
* ABX464 Dose 25 mg QD (all subjects who received 25 mg in induction)
* Subjects who were allocated to placebo in the induction study will be randomized to obefazimod 50 mg or 25 mg in a blinded manner.
Primary purpose: TREATMENT

Brief summary: This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhibitors, anti-integrins, anti-IL-23), and/or S1P receptor modulators, and/or JAK inhibitors\].

This study is the maintenance phase of both previous induction studies ABX464-105 and ABX464-106.

Detailed description: All eligible subjects who have completed either one of the induction studies above mentioned, will be given the opportunity to take part in the present ABX464-107 study which consists of 2 treatment phases.

This study consists of a 44-week maintenance treatment phase (Part 1 and Part 2), followed by a 4-year Long Term Extension (LTE) treatment phase and a 28-days follow-up period consisting in the End of Study (EOS) visit.

The maintenance phase is a 44-week double blind, placebo-controlled, phase. Subjects who are clinical responders after 8 weeks induction will be randomized to Part 1, and those who are non-clinical responders will be randomized to Part 2.

At the end of the 44-week maintenance phase, subjects will continue their allocated treatment until the maintenance phase is unblinded.

Once the study is unblinded, all subjects receiving obefazimod will continue their allocated treatment. Subjects receiving placebo will be allocated to obefazimod 25 mg or can terminate the study.

Eligibility criteria: Inclusion Criteria in maintenance phase:

* Subjects must have completed the induction treatment study (ABX464-105 or ABX464-106), and patients' clinical response status must be available.
* Subjects with a valid endoscopy performed at the end of the induction study and results from central reader available at Day 1.
* Subjects must understand, sign and date the written voluntary informed consent form at the visit prior to any protocol-specific procedures. For under-aged subjects, national requirements regarding consent should also be met.
* Women of childbearing potential (WOCBP) subjects and male subjects with WOCBP partner must agree to comply with contraception requirements as described in Section 4.4. (Contraception) of the protocol.
* Subjects must be able and willing to comply with study visits and procedures as per protocol.
* Subjects should be affiliated to a health insurance policy whenever required by a participating country or state

Inclusion criteria in LTE phase:

* Subject must have completed the maintenance phase
* Investigator and subject must assess and agree that the subject has received, and will continue to receive benefit from being in the study

Exclusion Criteria in maintenance phase:

* Subjects who permanently discontinued the study treatment during the induction study (either ABX464-105 or ABX464-106).
* Subjects who have developed any major illness/condition (eg. primary sclerosis cholangitis, Crohn's disease, colectomy, diverting ileostomy, colon cancer or colonic adenomas \[low or high grade dysplasia\]).
* Subjects with evidence of an unstable clinical condition (eg. toxic megacolon, fulminant colitis, bowel perforation, uncontrolled ischemic disease, congestive heart failure with NYHA class 3 or 4 symptoms) during the induction study that, in the investigator's judgment, will substantially increase the risk to the subject if he or she participates in the study.
* Subjects who plan to participate in other investigational studies during the maintenance study.
* Male or female planning a pregnancy, or pregnant female subjects
* Introduction during induction study of prohibited medications, dosages, surgical or non-medicinal procedures indicated for UC (except antidiarrheals and motility agents for acute diarrhea).
* Any changes in the laboratory values during the induction period that could jeopardize subject's safety in the opinion of the investigator. If any doubts, the investigator should contact the sponsor study medical monitor.
* Subject who is planning to receive live vaccine during the study.
* Subjects committed to an institution by virtue of an order issued either by the judicial or the administrative authorities.

Exclusion criteria for LTE phase:

* Subject continues to satisfy exclusion criteria listed above for the maintenance phase
* Introduction during maintenance phase of prohibited medications, dosages, surgical or non-medicinal procedures indicated for UC (except antidiarrheals and motility agents for acute diarrhea).

Primary outcomes:
measure: Rate of subjects in clinical remission at Week 44
timeFrame: Week 44
measure: Number and percentage of all treatment-emergent adverse events (TEAEs)
timeFrame: Week 44
measure: Number and percentage of all serious adverse events (SAEs)
timeFrame: Week 44
measure: Number and percentage of all causally related TEAEs/SAEs
timeFrame: Week 44
Secondary outcomes:
measure: Proportion of subjects with endoscopic improvement at Week 44
timeFrame: Week 44
measure: Proportion of subjects with corticosteroid-free clinical remission
timeFrame: Week 44
measure: Proportion of subjects with sustained clinical remission at Week 44
timeFrame: Week 44
measure: Proportion of subjects with HEMI per Geboes scoring at Week 44
timeFrame: Week 44
measure: Proportion of subjects with endoscopic remission at Week 44
timeFrame: Week 44
measure: LTE Phase - Proportion of subjects in clinical remission at Year 1
timeFrame: LTE Year 1
measure: LTE Phase - Proportion of subjects in clinical remission at Year 4
timeFrame: LTE Year 4
measure: LTE Phase - Proportion of subjects with corticosteroid-free clinical remission in the subpopulation with corticosteroids at maintenance study entry
timeFrame: LTE Year 1
measure: LTE Phase - Proportion of subjects with corticosteroid-free clinical remission in the subpopulation with corticosteroids at maintenance study entry)
timeFrame: LTE Year 4
measure: LTE Phase - Proportion of subjects with endoscopic improvement at LTE Year 1
timeFrame: LTE Year 1
measure: LTE Phase - Proportion of subjects with endoscopic improvement at LTE Year 4
timeFrame: LTE Year 4
measure: LTE Phase - Proportion of subjects with endoscopic remission at LTE year 1
timeFrame: LTE year 1
measure: LTE Phase - Proportion of subjects with endoscopic remission at LTE year 4
timeFrame: LTE year 4
measure: LTE Phase - Proportion of subjects with CS-free symptomatic remission by visit
timeFrame: 4 years
measure: LTE Phase - Proportion of subjects with HEMI per Geboes scoring at LTE Year 1
timeFrame: LTE Year 1
measure: LTE Phase - Proportion of subjects with HEMI per Geboes scoring at LTE Year 4
timeFrame: LTE Year 4
measure: LTE Phase - Proportion of subjects with HEMR per Geboes scoring at LTE Year 1
timeFrame: LTE Year 1
measure: LTE Phase - Proportion of subjects with HEMR per Geboes scoring at LTE Year 4
timeFrame: LTE Year 4
measure: LTE Phase - Proportion of subjects with sustained clinical remission at LTE Year 1, in the sub-population of subjects with clinical remission at Week 44
timeFrame: LTE Year 1
measure: LTE Phase - Proportion of subjects with sustained clinical remission at LTE year 4, in the sub-population of subjects with clinical remission at Week 44
timeFrame: LTE year 4
measure: LTE Phase - Proportion of subjects with sustained endoscopic improvement at LTE Year 1, in the sub-population of subjects with endoscopic improvement at Week 44
timeFrame: LTE Year 1
measure: LTE Phase - Proportion of subjects with sustained endoscopic improvement at LTE Year 4, in the sub-population of subjects with endoscopic improvement at Week 44
timeFrame: LTE year 4
measure: LTE Phase - Proportion of subjects with symptomatic remission by visit
timeFrame: 4 years
measure: LTE Phase - Proportion of subjects with sustained symptomatic remission by visit
timeFrame: 4 years
measure: LTE Phase - Proportion of subjects with CS-free clinical remission at LTE Year 1
timeFrame: LTE Year 1
measure: LTE Phase - Proportion of subjects with CS-free clinical remission at LTE Year 4
timeFrame: LTE Year 4
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama -Birmingham
state: Alabama
city: Dothan
country: United States
facility: Digestive Health Specialists of the Southeast
state: Alabama
city: Guntersville
country: United States
facility: Lakeview Clinical Research
state: Alabama
city: Litchfield Park
country: United States
facility: Research Solutions of Arizona, PC
state: Arizona
city: Phoenix
country: United States
facility: Valleywise Health Medical Center
state: Arizona
city: Sun City
country: United States
facility: GI Alliance
state: Arizona
city: Tucson
country: United States
facility: Del Sol Research Management, LLC
state: Arizona
city: Tucson
country: United States
facility: University of Arizona
state: Arizona
city: Little Rock
country: United States
facility: University of Arkansas for Medical Sciences
state: Arkansas
city: Little Rock
country: United States
facility: Applied Research Center of Arkansas
state: Arkansas
city: Bakersfield
country: United States
facility: National Institute of Clinical Research
state: California
city: Corona
country: United States
facility: Kindred Medical Institute for Clinical Trials, LLC
state: California
city: Costa Mesa
country: United States
facility: Aurora Care Clinic
state: California
city: Covina
country: United States
facility: Citrus Valley Gastroenterology
state: California
city: La Jolla
country: United States
facility: University of California (San Diego)
state: California
city: Lancaster
country: United States
facility: Gastro Care Institute
state: California
city: Murrieta
country: United States
facility: United Medical Doctors
state: California
city: Newport Beach
country: United States
facility: Hoag Memorial Hospital Presbyterian
state: California
city: Northridge
country: United States
facility: California Medical Research Associates Inc.
state: California
city: Orange
country: United States
facility: Clinnova Research Solutions
state: California
city: San Diego
country: United States
facility: Clinical Applications Laboratories
state: California
city: Aurora
country: United States
facility: Kaiser Foundation Research Institute, a Division of Kaiser Permanente Hospitals
state: Colorado
city: Colorado Springs
country: United States
facility: Peak Gastroenterology Associates
state: Colorado
city: Danbury
country: United States
facility: Danbury Hospital
state: Connecticut
city: Hamden
country: United States
facility: Medical Research Center of Connecticut, LLC
state: Connecticut
city: Brandon
country: United States
facility: Clinical Research Of Brandon, LLC
state: Florida
city: Brooksville
country: United States
facility: Access Research Institute
state: Florida
city: Clearwater
country: United States
facility: West Central Gastroenterology d/b/a Gastro Florida
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research, LLC
state: Florida
city: Kissimmee
country: United States
facility: I.H.S Health, LLC
state: Florida
city: Lakeland
country: United States
facility: Auzmer Research
state: Florida
city: Maitland
country: United States
facility: Cfagi, Llc
state: Florida
city: Miami Lakes
country: United States
facility: Wellness Clinical Research
state: Florida
city: Miami
country: United States
facility: Infinite Clinical Research Inc
state: Florida
city: Miami
country: United States
facility: Research Associates of South Florida, LLC
state: Florida
city: Miami
country: United States
facility: University of Miami
state: Florida
city: Miami
country: United States
facility: MedOne Clinical Research LLC
state: Florida
city: Miami
country: United States
facility: Nicklaus Children's Hospital
state: Florida
city: Miami
country: United States
facility: Sanchez Clinical Research, Inc
state: Florida
city: Miami
country: United States
facility: Medical Professional Clinical Research Center
state: Florida
city: Miami
country: United States
facility: Reliant Medical Research, LLC
state: Florida
city: Ocala
country: United States
facility: Ocala GI Research
state: Florida
city: Ocala
country: United States
facility: Sarkis Clinical Trials - Parent
state: Florida
city: Orlando
country: United States
facility: Endoscopic Research, Inc.
state: Florida
city: Orlando
country: United States
facility: Arnold Palmer Hospital For Children
state: Florida
city: Orlando
country: United States
facility: Omega Research Orlando, LLC
state: Florida
city: Orlando
country: United States
facility: Advanced Research Institute, Inc.
state: Florida
city: Pensacola
country: United States
facility: Gastroenterology Associates of Pensacola, PA
state: Florida
city: Saint Petersburg
country: United States
facility: Advanced Research Institute, Inc.
state: Florida
city: Tampa
country: United States
facility: Genesis Clinical Research
state: Florida
city: Tampa
country: United States
facility: GCP Clinical Research, LLC
state: Florida
city: Tampa
country: United States
facility: Guardian Angel Research Center
state: Florida
city: Tampa
country: United States
facility: Alliance Clinical Research
state: Florida
city: Atlanta
country: United States
facility: Digestive Healthcare of Georgia
state: Georgia
city: Decatur
country: United States
facility: Atlanta Center for Gastroenterology, P.C.
state: Georgia
city: Norcross
country: United States
facility: One Health Research Clinic Atlanta, LLC
state: Georgia
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine
state: Illinois
city: Chicago
country: United States
facility: Eagle Clinical Research
state: Illinois
city: Chicago
country: United States
facility: University of Chicago Medical Center
state: Illinois
city: Glenview
country: United States
facility: GI Alliance
state: Illinois
city: Gurnee
country: United States
facility: GI Alliance
state: Illinois
city: Indianapolis
country: United States
facility: Indiana University School of Medicine
state: Indiana
city: Clive
country: United States
facility: Iowa Digestive Disease Center
state: Iowa
city: Iowa City
country: United States
facility: The University of Iowa
state: Iowa
city: Kansas City
country: United States
facility: University of Kansas Medical Center Research Institute, Inc.
state: Kansas
city: Topeka
country: United States
facility: Cotton O'Neil Clinical Research Center
state: Kansas
city: Louisville
country: United States
facility: University of Louisville Research Foundation
state: Kentucky
city: Baton Rouge
country: United States
facility: GI Alliance - Baton Rouge
state: Louisiana
city: Marrero
country: United States
facility: Tandem Clinical Research, LLC
state: Louisiana
city: Baltimore
country: United States
facility: University of Maryland Medical Center
state: Maryland
city: Boston
country: United States
facility: Boston Medical Center
state: Massachusetts
city: Fall River
country: United States
facility: NECCR Primacare Research, LLC
state: Massachusetts
city: New Bedford
country: United States
facility: Lucida Clinical Trials LLC
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
city: Chesterfield
country: United States
facility: Clinical Research Institute of Michigan, LLC
state: Michigan
city: Farmington Hills
country: United States
facility: Michigan Center of Medical Research
state: Michigan
city: Sterling Heights
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Flowood
country: United States
facility: Gastrointestinal Associates, PA
state: Mississippi
city: Ocean Springs
country: United States
facility: Digestive Health Center PA
state: Mississippi
city: Liberty
country: United States
facility: BVL Clinical Research
state: Missouri
city: Omaha
country: United States
facility: University of Nebraska Medical Center
state: Nebraska
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center
state: New Hampshire
city: Egg Harbor Township
country: United States
facility: AGA Clinical Research Associates, LLC
state: New Jersey
city: Florham Park
country: United States
facility: AIG Digestive Disease Research
state: New Jersey
city: Brooklyn
country: United States
facility: NY Scientific Corp.
state: New York
city: New York
country: United States
facility: Mount Sinai
state: New York
city: Rochester
country: United States
facility: Rochester Clinical Research
state: New York
city: Charlotte
country: United States
facility: Charlotte Gastroenterology and Hepatology, P.L.L.C
state: North Carolina
city: Lumberton
country: United States
facility: Care Access Research Lumberton
state: North Carolina
city: Wilmington
country: United States
facility: Wilmington Health
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist
state: North Carolina
city: Fargo
country: United States
facility: Plains Clinical Research Center, LLC
state: North Dakota
city: Cincinnati
country: United States
facility: Gastro Health Research
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals Cleveland Medical Center
state: Ohio
city: Columbus
country: United States
facility: Wexner Medical Center
state: Ohio
city: Springboro
country: United States
facility: DSI Research LLC
state: Ohio
city: Oklahoma City
country: United States
facility: Hightower Clinical
state: Oklahoma
city: Oklahoma City
country: United States
facility: Board of Regents of the University of Oklahoma Health Sciences Center
state: Oklahoma
city: Harrisburg
country: United States
facility: Susquehanna Research Group, LLC
state: Pennsylvania
city: Pittsburgh
country: United States
facility: UPMC
state: Pennsylvania
city: Uniontown
country: United States
facility: Frontier Clinical Research, LLC
state: Pennsylvania
city: Columbia
country: United States
facility: Columbia Digestive Health Research
state: South Carolina
city: Greenville
country: United States
facility: Gastroenterology Associates, PA
state: South Carolina
city: Rapid City
country: United States
facility: Rapid City Medical Center, LLC
state: South Dakota
city: Germantown
country: United States
facility: Gastroenterology Center of the MidSouth PC
state: Tennessee
city: Hermitage
country: United States
facility: Digestive Health Research, LC
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
city: Arlington
country: United States
facility: Texas Clinical Research Institute, LLC
state: Texas
city: Austin
country: United States
facility: Central Texas Clinical Research, LLC
state: Texas
city: Austin
country: United States
facility: Amel Med LLC
state: Texas
city: Baytown
country: United States
facility: Inquest Clinical Research
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants
state: Texas
city: Dallas
country: United States
facility: Baylor Scott and White
state: Texas
city: Fort Worth
country: United States
facility: Cook Children's Medical Center
state: Texas
city: Fort Worth
country: United States
facility: Valley Institute of Research
state: Texas
city: Garland
country: United States
facility: GI Alliance - Garland
state: Texas
city: Houston
country: United States
facility: Baylor College Of Medicine
state: Texas
city: Houston
country: United States
facility: Houston Methodist Hospital
state: Texas
city: Houston
country: United States
facility: Biopharma Informatic, Inc. Research Center
state: Texas
city: Houston
country: United States
facility: Biopharma Informatic, LLC
state: Texas
city: Katy
country: United States
facility: Gastro Health & Nutrition
state: Texas
city: Katy
country: United States
facility: Mt.Olympus Medical Research
state: Texas
city: Pasadena
country: United States
facility: Digestive System Healthcare
state: Texas
city: Pearland
country: United States
facility: LinQ Research, LLC
state: Texas
city: San Marcos
country: United States
facility: GI Alliance - San Marcos
state: Texas
city: Southlake
country: United States
facility: GI Alliance - Southlake
state: Texas
city: Spring
country: United States
facility: Texas Gastroenterology Associates
state: Texas
city: Tyler
country: United States
facility: Tyler Research Institute, LLC
state: Texas
city: Webster
country: United States
facility: GI Alliance - Webster
state: Texas
city: Ogden
country: United States
facility: Care Access Research LLC
state: Utah
city: Salt Lake City
country: United States
facility: University of Utah
state: Utah
city: Chesapeake
country: United States
facility: Gastroenterology Associates of Tidewater
state: Virginia
city: Lynchburg
country: United States
facility: Blue Ridge Medical Research
state: Virginia
city: Roanoke
country: United States
facility: Gastroenterology Consultants and Endoscopy Center of Southwest Virginia
state: Virginia
city: Williamsburg
country: United States
facility: TPMG Clinical Research Williamsburg
state: Virginia
city: Seattle
country: United States
facility: University of Washington
state: Washington
city: Vancouver
country: United States
facility: The Vancouver Clinic
state: Washington
city: Quilmes
country: Argentina
facility: Instituto de Investigaciones Clinicas Quilmes
state: Buenos Aires
city: Córdoba
country: Argentina
facility: Hospital Privado Centro Medico de Cordoba S.A
state: Cordoba
city: San Miguel De Tucumán
country: Argentina
facility: Centro de Investigacion CICE
state: Tucuman
city: San Miguel De Tucumán
country: Argentina
facility: Centro de Investigaciones Medicas Tucuman
state: Tucuman
city: Buenos Aires
country: Argentina
facility: CEMIC
city: Buenos Aires
country: Argentina
facility: STAT Research S.A.
city: Buenos Aires
country: Argentina
facility: Hospital Italiano de Buenos Aires
city: Buenos Aires
country: Argentina
facility: Hospital Britanico de Buenos Aires
city: Blacktown
country: Australia
facility: Blacktown Hospital
state: New South Wales
city: Concord
country: Australia
facility: Concord Repatriation General Hospital
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital
state: New South Wales
city: Herston
country: Australia
facility: Royal Brisbane and Women's Hospital
state: Queensland
city: North Mackay
country: Australia
facility: Coral Sea Clinical Research Institute
state: Queensland
city: South Brisbane
country: Australia
facility: Mater Hospital Brisbane
state: Queensland
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital
state: Queensland
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: Fitzroy
country: Australia
facility: St Vincent's Hospital Melbourne
state: Victoria
city: Footscray
country: Australia
facility: Footscray Hospital
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Health
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Graz
country: Austria
facility: LKH - Universitaetsklinikum Graz
city: Innsbruck
country: Austria
facility: Medizinische Universität Innsbruck
city: Linz
country: Austria
facility: Ordensklinikum Linz GmbH - Barmherzige Schwestern
city: Salzburg
country: Austria
facility: LKH - Universitätsklinikum der PMU Salzburg
city: St Veit an der Glan
country: Austria
facility: KH der Barmherzigen Brüder St.Veit an der Glan
city: Antwerpen
country: Belgium
facility: GZA Ziekenhuizen
city: Brasschaat
country: Belgium
facility: AZ Klina
city: Brussel
country: Belgium
facility: Universitair Ziekenhuis Brussel
city: Bruxelles
country: Belgium
facility: C. H. U. St-Pierre
city: Gent
country: Belgium
facility: AZ Maria Middelares
city: Gent
country: Belgium
facility: AZ Sint-Lucas
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent
city: Leuven
country: Belgium
facility: UZ Leuven
city: Liège
country: Belgium
facility: Clinique CHC MontLégia
city: Roeselare
country: Belgium
facility: AZ Delta
city: Yvoir
country: Belgium
facility: CHU UCL Namur
city: Salvador
country: Brazil
facility: Hospital Aliança
state: Bahia
city: Brasília
country: Brazil
facility: L2IP - Instituto de Pesquisas Clínicas Ltda.
state: Distrito Federal
city: Belo Horizonte
country: Brazil
facility: Hospital Felício Rocho
state: Minas Gerais
city: Curitiba
country: Brazil
facility: CDC - Centro Digestivo de Curitiba
state: Paraná
city: Caxias Do Sul
country: Brazil
facility: Instituto de Pesquisas em Saúde - Fundação Universidade de Caxias do Sul (IPS/FUCS)
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Moinhos de Vento
state: Rio Grande Do Sul
city: Botucatu
country: Brazil
facility: UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu
state: Sao Paulo
city: Jaú
country: Brazil
facility: CECIP - Centro de Estudos Clínicos do Interior Paulista
state: Sao Paulo
city: Santo André
country: Brazil
facility: Pesquisare Saúde
state: Sao Paulo
city: Santo André
country: Brazil
facility: Praxis Pesquisa Médica
state: Sao Paulo
city: Santos
country: Brazil
facility: Irmandade da Santa Casa da Misericórdia de Santos
state: Sao Paulo
city: São Paulo
country: Brazil
facility: Hepatogastro
state: Sao Paulo
city: Pleven
country: Bulgaria
facility: Medical center Medconsult Pleven OOD
city: Sofia
country: Bulgaria
facility: DCC "Alexandrovska", EOOD
city: Sofia
country: Bulgaria
facility: UMHATEM 'N.I. Pirogov', EAD
city: Sofia
country: Bulgaria
facility: Diagnostic Consultation Center CONVEX EOOD
city: Sofia
country: Bulgaria
facility: ACIBADEM CityClinic Oncological center
city: Veliko Tarnovo
country: Bulgaria
facility: MC Medica Plus
city: Edmonton
country: Canada
facility: Gastroenterology and Internal Medicine Research Institute (GIRI)
state: Alberta
city: Vancouver
country: Canada
facility: (G.I.R.I.) GI Research Institute
state: British Columbia
city: London
country: Canada
facility: London Health Sciences Centre (LHSC) - Victoria Hospital
state: Ontario
city: North Bay
country: Canada
facility: Scott Shulman Medicine Professional Corporation
state: Ontario
city: North York
country: Canada
facility: Toronto Immune & Digestive Health Institute
state: Ontario
city: Montréal
country: Canada
facility: Montreal General Hospital
state: Quebec
city: Bengbu
country: China
facility: The First Affiliated Hospital of Bengbu Medical College
state: Anhui
city: Wuhu
country: China
facility: Yijishan Hospital of Wannan Medical College
state: Anhui
city: Beijing
country: China
facility: Peking University First Hospital
state: Beijing
city: Fuzhou
country: China
facility: The First Affiliated Hospital of Fujian Medical University
state: Fujian
city: Fuzhou
country: China
facility: The 900th Hospital of The Chinese People's Liberation Army Joint Logistics Support Force
state: Fujian
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Sun Yat-sen University
state: Guangdong
city: Guangzhou
country: China
facility: Nanfang Hospital of Southern Medical University
state: Guangdong
city: Guangzhou
country: China
facility: The Sixth Affiliated Hospital of Sun Yat-sen University
state: Guangzhou
city: Luoyang
country: China
facility: The First Affiliated Hospital of Henan University of Science and Technology
state: Henan
city: Zhengzhou
country: China
facility: The First Affiliated Hospital of Zhengzhou University
state: Henan
city: Wuhan
country: China
facility: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
state: Hubei
city: Wuhan
country: China
facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
state: Hubei
city: Wuhan
country: China
facility: Renmin Hospital, Wuhan University
state: Hubei
city: Changsha
country: China
facility: The 2nd Xiangya Hospital of Central South University
state: Hunan
city: Hengyang
country: China
facility: The First Affiliated Hospital of University of South China
state: Hunan
city: Changzhou
country: China
facility: Changzhou No.2 People's Hospital
state: Jiangsu
city: Nanjing
country: China
facility: General Hospital of Eastern Theater Command
state: Jiangsu
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical College
state: Jiangsu
city: Ganzhou
country: China
facility: Jiangxi Gannan Medical College Affiliated 1 st Hospital
state: Jiangxi
city: Ganzhou
country: China
facility: The First Affiliated Hospital of Gannan Medical University
state: Jiangxi
city: Nanchang
country: China
facility: The Second Affiliated Hospital of Nanchang University
state: Jiangxi
city: Changchun
country: China
facility: The First Hospital of Jilin University
state: Jilin
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University, Hua Xiang branch hospital
state: Liaoning
city: Binzhou
country: China
facility: Binzhou Medical University Hospital
state: Shandong
city: Jinan
country: China
facility: Qilu Hospital of Shandong University
state: Shandong
city: Jinan
country: China
facility: Jinan Central Hospital
state: Shandong
city: Qingdao
country: China
facility: The Affiliated Hospital of Qingdao University
state: Shandong
city: Tai'an
country: China
facility: Taian City Central Hospital
state: Shandong
city: Shanghai
country: China
facility: Renji Hospital Shanghai Jiaotong University School of Medicine - West Branch
state: Shanghai
city: Shanghai
country: China
facility: Shanghai General Hospital
state: Shanghai
city: Tianjin
country: China
facility: Tianjin Union Medical Center
state: Tianjin
city: Kunming
country: China
facility: First Affiliated Hospital of Kunming Medical University
state: Yunnan
city: Hangzhou
country: China
facility: The First Affiliated Hospital, College of Medicine, Zhejiang University
state: Zhejiang
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
state: Zhejiang
city: Koprivnica
country: Croatia
facility: General Hospital "Dr.Tomislav Bardek" Koprivnica
city: Osijek
country: Croatia
facility: Clinical Hospital Centre Osijek
city: Zagreb
country: Croatia
facility: University hospital centre Zagreb
city: Brno
country: Czechia
facility: CCR Brno, s.r.o.
city: Brno
country: Czechia
facility: SurGal Clinic s.r.o.
city: Hradec Kralove
country: Czechia
facility: Hepato-Gastroenterologie HK s.r.o.
city: Olomouc
country: Czechia
facility: PreventaMed s.r.o.
city: Ostrava
country: Czechia
facility: CCR Ostrava s.r.o.
city: Ostrava
country: Czechia
facility: Fakultni nemocnice Ostrava
city: Praha 4
country: Czechia
facility: Institut klinicke a experimentalni mediciny
city: Slaný
country: Czechia
facility: Nemocnice Slany
city: Nice
country: France
facility: CHU Nice - Hôpital de l'Archet 2
state: Alpes Maritimes
city: Reims
country: France
facility: CHU Reims - Hôpital Robert Debré
state: Ardennes
city: Marseille
country: France
facility: Hôpital Nord - CHU Marseille
state: Bouches-du-Rhône
city: Caen
country: France
facility: CHU Caen - Hôpital de la Côte de Nacre
state: Calvados
city: Dijon
country: France
facility: CHU Dijon - Hôpital Bocage Central
state: Cote dÝOr
city: Besançon
country: France
facility: CHU Besançon - Hôpital Jean Minjoz
state: Doubs
city: Pessac
country: France
facility: CHU Bordeaux - Hôpital Haut-Lévêque
state: Gironde
city: Toulouse
country: France
facility: Hopital Rangueil
state: Haute Garonne
city: Neuilly
country: France
facility: Institut des MICI
state: Hauts De Seine
city: Montpellier
country: France
facility: Hopital Saint Eloi
state: Herault
city: Rennes
country: France
facility: CHU Rennes - Hôpital Pontchaillou
state: Ille Et Vilaine
city: Grenoble
country: France
facility: CHU de Grenoble - Hôpital Albert Michallon
state: Isère
city: Nantes
country: France
facility: CHU Nantes - Hôtel Dieu
state: Loire Atlantique
city: Saint-Étienne
country: France
facility: CHU Saint Etienne - Hôpital Nord
state: Loire
city: Vandœuvre-lès-Nancy
country: France
facility: Universite de Lorraine - Faculte de Medecine - INSERM U954
state: Meurthe Et Moselle
city: Lille
country: France
facility: CHU Lille - Hôpital Claude Huriez
state: Nord
city: Clermont-Ferrand
country: France
facility: CHU Clermont Ferrand - Hopital d'Estaing
state: Puy De Dome
city: Pau
country: France
facility: Centre Hospitalier de Pau - Hôpital François Mitterrand
state: Pyrenees Atlantiques
city: Pierre-Bénite
country: France
facility: Centre Hospitalier Lyon Sud
state: Rhone
city: Amiens
country: France
facility: CHU Amiens - Hopital Sud
state: Somme
city: Créteil
country: France
facility: Hôpital Henri Mondor
state: Val De Marne
city: Le Kremlin-Bicêtre
country: France
facility: Hôpital Bicêtre
state: Val De Marne
city: La Roche-sur-Yon
country: France
facility: Centre Hospitalier Départemental Les Oudairies
state: Vendée
city: Paris
country: France
facility: Hôpital Saint-Louis
city: Freiburg
country: Germany
facility: Universitaetsklinikum Freiburg
state: Baden Wuerttemberg
city: Heidelberg
country: Germany
facility: Universitaetsklinikum Heidelberg
state: Baden Wuerttemberg
city: Heidelberg
country: Germany
facility: Praxis fuer Gasroenterologie Prof. Dr. med Robert Ehehalt
state: Baden Wuerttemberg
city: Nürtingen
country: Germany
facility: Medius Klinik Nuertingen
state: Baden Wuerttemberg
city: Pforzheim
country: Germany
facility: Siloah St. Trudpert Klinikum
state: Baden Wuerttemberg
city: Tuebingen
country: Germany
facility: Universitaetsklinikum Tuebingen
state: Baden Wuerttemberg
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm
state: Baden Wuerttemberg
city: Erlangen
country: Germany
facility: Universitaetsklinikum Erlangen
state: Bayern
city: Muenchen
country: Germany
facility: LMU-Campus Grosshadern
state: Bayern
city: Frankfurt am Main
country: Germany
facility: Universitaetsklinikum Frankfurt Goethe-Universitaet
state: Hessen
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
state: Niedersachsen
city: Ludwigshafen
country: Germany
facility: INLUGA im Haus der Gesundheit
state: Rheinland Pfalz
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein - Campus Kiel
state: Schleswig Holstein
city: Berlin
country: Germany
facility: Charité - Campus Charité Mitte
city: Berlin
country: Germany
facility: Gastroenterologie Berlin Karlshorst
city: Berlin
country: Germany
facility: Charité - Campus Benjamin Franklin
city: Berlin
country: Germany
facility: DRK Kliniken Berlin Westend
city: Hamburg
country: Germany
facility: Hamburgisches Forschungsinstitut fure Chronische Darmerkrankungen
city: Athens
country: Greece
facility: General Hospital of Athens "Evangelismos"
city: Corfu
country: Greece
facility: Corfu General Hospital "St. Eirini"
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion
city: Thessaloníki
country: Greece
facility: General Hospital of Thessaloniki "Hippokration"
city: Budapest
country: Hungary
facility: Clinexpert Kft.
city: Budapest
country: Hungary
facility: Semmelweis Egyetem
city: Budapest
country: Hungary
facility: Semmelweis Egyetem
city: Budapest
country: Hungary
facility: Pannonia Maganorvosi Centrum
city: Békéscsaba
country: Hungary
facility: Bekes Varmegyei Kozponti Korhaz
city: Gyongyos
country: Hungary
facility: Gyongyosi Bugat Pal Korhaz
city: Szekszard
country: Hungary
facility: Clinfan Szolgaltato Kft.
city: Hyderabad
country: India
facility: Origin Hospital
state: Andhra Pradesh
city: Hyderabad
country: India
facility: Yashoda Super Speciality Hospital
state: Andhra Pradesh
city: Secunderabad
country: India
facility: Gandhi Hospital
state: Andhra Pradesh
city: New Delhi
country: India
facility: Fortis Escorts Heart Institute and Research Centre
state: Delhi
city: New Delhi
country: India
facility: Maharaja Agrasen Hospital
state: Delhi
city: New Delhi
country: India
facility: All India Institute of Medical Sciences
state: Delhi
city: Ahmedabad
country: India
facility: Navneet Memorial Hospital 'Sushrusha'
state: Gujarat
city: Rajkot
country: India
facility: Shree Giriraj Multispeciality Hospital
state: Gujarat
city: Sūrat
country: India
facility: Surat Institute of Digestive Sciences
state: Gujarat
city: Sūrat
country: India
facility: Gujarat Hospital
state: Gujarat
city: Sūrat
country: India
facility: Unity Hospital ICU and Trauma
state: Gujarat
city: Vadodara
country: India
facility: Isha Multispeciality Hospital
state: Gujarat
city: Gurgaon
country: India
facility: Fortis Memorial Research Institute
state: Haryana
city: Bangalore
country: India
facility: M. S. Ramaiah Medical College and Hospital
state: Karnataka
city: Belagave
country: India
facility: K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre
state: Karnataka
city: Mangalore
country: India
facility: Vinaya Hospital and Research Center
state: Karnataka
city: Cochin
country: India
facility: Lakeshore Hospital and Research Centre Ltd.
state: Kerala
city: Cochin
country: India
facility: Amrita Institute Of Medical Sciences and Research Centre
state: Kerala
city: Mumbai
country: India
facility: King Edward Memorial Hospital Research Centre
state: Maharashtra
city: Mumbai
country: India
facility: Lokmanya Tilak Municipal General Hospital & Medical College
state: Maharashtra
city: Nagpur
country: India
facility: Kingsway Hospital
state: Maharashtra
city: Nagpur
country: India
facility: Midas Multispeciality Hospital Pvt Ltd
state: Maharashtra
city: Nashik
country: India
facility: Chopda Medicare & Research Centre
state: Maharashtra
city: Pune
country: India
facility: Ruby Hall Clinic
state: Maharashtra
city: Pune
country: India
facility: Sahyadri Specialty Hospital
state: Maharashtra
city: Wardha
country: India
facility: Datta Meghe Institute of Medical Sciences (Deemed University)
state: Maharashtra
city: Ludhiāna
country: India
facility: Dayanand Medical College and Hospital
state: Punjab
city: Jaipur
country: India
facility: S. R. Kalla Memorial Gastro & General Hospital
state: Rajasthan
city: Chennai
country: India
facility: SRM Institutes for Medical Sciences
state: Tamilnadu
city: Lucknow
country: India
facility: Chhatrapati Shahuji Maharaj (CSM) Medical University
state: Uttar Pradesh
city: Kolkata
country: India
facility: Nil Ratan Sircar Medical College
state: West Bengal
city: Kolkata
country: India
facility: Institute of Post Graduate Medical Education And Research
state: West Bengal
city: Chandigarh
country: India
facility: Postgraduate Institute of Medical Education and Research
city: Mullingar
country: Ireland
facility: Midland Regional Hospital
state: Westmeath
city: Dublin
country: Ireland
facility: Connolly Hospital
city: Dublin
country: Ireland
facility: St Vincents University Hospital
city: Galway
country: Ireland
facility: Portiuncula Hospital
city: Louth
country: Ireland
facility: Our Lady of Lourdes
city: Afula
country: Israel
facility: HaEmek Medical Center
city: Be'er Sheva
country: Israel
facility: Soroka University Medical Center
city: Haifa
country: Israel
facility: Bnai Zion Medical Center
city: Holon
country: Israel
facility: Wolfson Medical Center
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
city: Kfar- Sava
country: Israel
facility: Meir Medical Center
city: Petach Tikva
country: Israel
facility: Rabin Medical Center-Beilinson Campus
city: Ramat Gan
country: Israel
facility: Chaim Sheba Medical Center
city: Rehovot
country: Israel
facility: Kaplan Medical Center KMC Institute of Gastroenterology and Liver Diseases
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center
city: San Giovanni Rotondo
country: Italy
facility: IRCCS Ospedale Casa Sollievo della Sofferenza
state: Foggia
city: Rho
country: Italy
facility: Ospedale di Circolo
state: Milano
city: Rozzano
country: Italy
facility: Ospedale San Raffaele
state: Milano
city: San Donato Milanese
country: Italy
facility: I.R.C.C.S Policlinico San Donato
state: Milano
city: Negrar
country: Italy
facility: Ospedale Sacro Cuore Don Calabria
state: Verona
city: Alessandria
country: Italy
facility: Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo
city: Bologna
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
city: Brescia
country: Italy
facility: Fondazione Poliambulanza Istituto Ospedaliero
city: Cagliari
country: Italy
facility: Azienda Ospedaliera Giuseppe Brotzu
city: Catania
country: Italy
facility: Presidio Ospedaliero Garibaldi Nesima
city: Catanzaro
country: Italy
facility: Azienda Ospedaliero Universitaria Mater Domini
city: Milano
country: Italy
facility: Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico
city: Milano
country: Italy
facility: Azienda Socio Sanitaria Territoriale Fatebenefratelli (Presidio Ospedale Sacco)
city: Napoli
country: Italy
facility: Azienda Ospedaliera Universitaria- Università degli Studi della Campania "Luigi Vanvitelli"
city: Padova
country: Italy
facility: Azienda Ospedaliera di Padova
city: Palermo
country: Italy
facility: Ospedale Cervello
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico San Matteo
city: Pisa
country: Italy
facility: Azienda Ospedaliero Universitaria Pisana (Presidio di Cisanello)
city: Roma
country: Italy
facility: Università Campus Bio-Medico di Roma
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
city: Udine
country: Italy
facility: Azienda Sanitaria Universitaria Integrata di Udine
city: Vicenza
country: Italy
facility: Ospedale San Bortolo di Vicenza
city: Toyohashi-shi
country: Japan
facility: Toyohashi Municipal Hospital
state: Aichi-Ken
city: Kashiwa-shi
country: Japan
facility: Kokikai Tsujinaka Hospital Kashiwanoha
state: Chiba-Ken
city: Matsuyama-shi
country: Japan
facility: Ehime Prefectural Central Hospital
state: Ehime-Ken
city: Chikushino-shi
country: Japan
facility: Fukuoka University Chikushi Hospital
state: Fukuoka-Ken
city: Iizuka-shi
country: Japan
facility: Aso Co.,Ltd Iizuka Hospital
state: Fukuoka-Ken
city: Kurume-shi
country: Japan
facility: Kurume University Hospital
state: Fukuoka-Ken
city: Kurume-shi
country: Japan
facility: Our Lady of the Snow St. Mary's Hospital
state: Fukuoka-Ken
city: Ota-shi
country: Japan
facility: SUBARU Health Insurance Society Ota Memorial Hospital
state: Gunma-Ken
city: Fukuyama-shi
country: Japan
facility: NHO Fukuyama Medical Center
state: Hiroshima-Ken
city: Hatsukaichi-shi
country: Japan
facility: JA-Hiroshima General Hospital
state: Hiroshima-Ken
city: Hiroshima-shi
country: Japan
facility: Hiroshima Prefectural Hospital
state: Hiroshima-Ken
city: Kure-shi
country: Japan
facility: NHO Kure Medical Center and Chugoku Cancer Center
state: Hiroshima-Ken
city: Asahikawa-shi
country: Japan
facility: Asahikawa Medical University Hospital
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: JCHO Hokkaido Hospital
state: Hokkaido
city: Kobe-shi
country: Japan
facility: Aoyama Clinic
state: Hyogo-Ken
city: Kanazawa-shi
country: Japan
facility: NHO Kanazawa Medical Center
state: Ishikawa-Ken
city: Takamatsu-shi
country: Japan
facility: Takamatsu Red Cross Hospital
state: Kagawa-Ken
city: Takamatsu-shi
country: Japan
facility: Kagawa Prefectural Central Hospital
state: Kagawa-Ken
city: Kagoshima-shi
country: Japan
facility: Jiaikai Izuro Imamura Hospital
state: Kagoshima-Ken
city: Kagoshima-shi
country: Japan
facility: Kagoshima IBD Gastroenterology Clinic
state: Kagoshima-Ken
city: Kagoshima-shi
country: Japan
facility: Sameshima Hospital
state: Kagoshima-Ken
city: Kamakura-shi
country: Japan
facility: Gokeikai Ofuna Chuo Hospital
state: Kanagawa-Ken
city: Kawasaki-shi
country: Japan
facility: Kawasaki Municipal Hospital
state: Kanagawa-Ken
city: Yokohama-shi
country: Japan
facility: Keijinkai Matsushima Hospital
state: Kanagawa-Ken
city: Yokohama-shi
country: Japan
facility: Showa University Northern Yokohama Hospital
state: Kanagawa-Ken
city: Kumamoto-shi
country: Japan
facility: Kaiseikai Hattori Clinic
state: Kumamoto-Ken
city: Tsu-shi
country: Japan
facility: Mie University Hospital
state: Mie-Ken
city: Nagaoka-shi
country: Japan
facility: Nagaoka Red Cross Hospital
state: Niigata-Ken
city: Niigata-shi
country: Japan
facility: Saiseikai Niigata Hospital
state: Niigata-Ken
city: Oita-shi
country: Japan
facility: Ishida Clinic of IBD and Gastroenterology
state: Oita-Ken
city: Okayama-shi
country: Japan
facility: Okayama University Hospital
state: Okayama-Ken
city: Okayama-shi
country: Japan
facility: NHO Okayama Medical Center
state: Okayama-Ken
city: Okinawa-shi
country: Japan
facility: Keiaikai Nakagami Hospital
state: Okinawa-Ken
city: Fujiidera-shi
country: Japan
facility: Shinseikai Sai Gastroenterology, Proctology
state: Osaka-Fu
city: Osaka-shi
country: Japan
facility: Kinshukai Infusion Clinic
state: Osaka-Fu
city: Osaka-shi
country: Japan
facility: NHO Osaka National Hospital
state: Osaka-Fu
city: Osaka-shi
country: Japan
facility: JCHO Osaka Hospital
state: Osaka-Fu
city: Saga-shi
country: Japan
facility: Saga-Ken Medical Centre Koseikan
state: Saga-Ken
city: Saga-shi
country: Japan
facility: Saga University Hospital
state: Saga-Ken
city: Ureshino-shi
country: Japan
facility: NHO Ureshino Medical Center
state: Saga-Ken
city: Kumagaya-shi
country: Japan
facility: Kumagaya General Hospital
state: Saitama-Ken
city: Hamamatsu-shi
country: Japan
facility: Matsuaikai Matsuda Hospital
state: Shizuoka-Ken
city: Bunkyo-ku
country: Japan
facility: Tokyo Medical and Dental University Hospital
state: Tokyo-To
city: Koto-Ku
country: Japan
facility: Showa University Koto Toyosu Hospital
state: Tokyo-To
city: Minato-ku
country: Japan
facility: Kitasato University Kitasato Institute Hospital
state: Tokyo-To
city: Shinjuku-Ku
country: Japan
facility: JCHO Tokyo Yamate Medical Center
state: Tokyo-To
city: Sumida-ku
country: Japan
facility: Tokyo Metropolitan Bokutoh Hospital
state: Tokyo-To
city: Ibaraki
country: Japan
facility: NHO Mito Medical Center
city: Ansan-si
country: Korea, Republic of
facility: Korea University Ansan Hospital
state: Chungcheongbuk-do
city: Wŏnju
country: Korea, Republic of
facility: Yonsei University Wonju Severance Christian Hospital
state: Gangwon-do
city: Seongnam-si
country: Korea, Republic of
facility: CHA Bundang Medical Center, CHA University
state: Gyeonggi-do
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
city: Suwon-si
country: Korea, Republic of
facility: The Catholic University of Korea, St. Vincent's Hospital
state: Gyeonggi-do
city: Daegu
country: Korea, Republic of
facility: Yeungnam University Hospital
state: Gyeongsangbuk-do
city: Busan
country: Korea, Republic of
facility: Inje University Haeundae Paik Hospital
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Hospital
city: Daejeon
country: Korea, Republic of
facility: The Catholic University of Korea, Daejeon St. Mary's Hospital
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St. Mary's Hospital
city: Seoul
country: Korea, Republic of
facility: Chung-Ang University Hospital
city: Kaunas
country: Lithuania
facility: Lithuanian University of Health Sciences Kaunas Hospital
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics
city: Klaipeda
country: Lithuania
facility: Klaipeda University Hospital branch "Seamen's Hospital"
city: Irapuato
country: Mexico
facility: Consultorio Medico, InvesclinicMX
state: Guanajuato
city: Monterrey
country: Mexico
facility: Accelerium S de RL de CV
state: Nuevo León
city: Monterrey
country: Mexico
facility: Inspirepharma S. de R.L. de C.V.
state: Nuevo León
city: Monterrey
country: Mexico
facility: Christus Muguerza Sur S.A. de C.V.
state: Nuevo León
city: Veracruz
country: Mexico
facility: FAICIC S. de R.L. de C.V.
city: Veracruz
country: Mexico
facility: Sociedad de Metabolismo y Corazon S.C
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, Locatie AMC
city: Geleen
country: Netherlands
facility: Zuyderland Medisch Centrum - Sittard-Geleen
city: Nijmegen
country: Netherlands
facility: Radboud UMC
city: Rotterdam
country: Netherlands
facility: Erasmus MC
city: Tilburg
country: Netherlands
facility: ETZ Elisabeth
city: Uden
country: Netherlands
facility: Bernhoven Uden
city: Utrecht
country: Netherlands
facility: UMC Utrecht
city: Christchurch
country: New Zealand
facility: Christchurch Hospital NZ
city: Dunedin
country: New Zealand
facility: Dunedin Hospital
city: Hamilton
country: New Zealand
facility: Waikato Hospital
city: Tauranga
country: New Zealand
facility: Tauranga Hospital
city: Belchatow
country: Poland
facility: Przychodnia Specjalistyczna Insula
city: Bialystok
country: Poland
facility: Uniwersytecki Szpital Kliniczny w Bialymstoku
city: Bydgoszcz
country: Poland
facility: NZOZ Centrum Medyczne KERmed
city: Gdynia
country: Poland
facility: Centrum Medyczne Pratia Gdynia
city: Kalisz
country: Poland
facility: Trialmed CRS
city: Kielce
country: Poland
facility: Polimedica Centrum Badań, Profilaktyki I Leczenia
city: Knurów
country: Poland
facility: Indywidualna Specjalistyczna Praktyka Lekarska Maciej Zymla
city: Kraków
country: Poland
facility: Centrum Medyczne Plejady
city: Kraków
country: Poland
facility: NZOZ Centrum Medyczne ProMiMed
city: Lublin
country: Poland
facility: 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie
city: Nowy Targ
country: Poland
facility: ALLMEDICA sp. z o. o.
city: Olsztyn
country: Poland
facility: Wojewodzki Specjalistyczny Szpital w Olsztynie
city: Opole
country: Poland
facility: Twoja Przychodnia Opolskie Centrum Medyczne
city: Oswiecim
country: Poland
facility: Medicome Sp. z o.o.
city: Poznań
country: Poland
facility: SOLUMED Centrum Medyczne
city: Poznań
country: Poland
facility: NSZOZ Termedica - Centrum Badan Klinicznych
city: Poznań
country: Poland
facility: Twoja Przychodnia PCM
city: Rzeszów
country: Poland
facility: Gabinet Lekarski Bartosz Korczowski
city: Sosnowiec
country: Poland
facility: Kiepury Clinic MAŁGORZATA JARNOT SPECJALISTYCZNA PRAKTYKA GINEKOLOGICZNO-POŁOŻNICZA
city: Staszów
country: Poland
facility: KO-MED Centra Kliniczne Staszow
city: Szczecin
country: Poland
facility: Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o.
city: Tarnów
country: Poland
facility: CenterMed Sp. z o.o.
city: Warsaw
country: Poland
facility: Centrum Zdrowia MDM
city: Warszawa
country: Poland
facility: NZOZ VIVAMED Jadwiga Miecz
city: Wrocław
country: Poland
facility: Centrum Medyczne Oporow
city: Wrocław
country: Poland
facility: Ars-Medica S.C Rybak Maria, Rybak Zbigniew
city: Zamość
country: Poland
facility: ETG Zamosc
city: Łódź
country: Poland
facility: Santa Familia Centrum Badan, Profilaktyki i Leczenia
city: Łódź
country: Poland
facility: AMICARE spółka z ograniczoną odpowiedzialnością spółka komandytowa
city: Łęczna
country: Poland
facility: Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej
city: Świdnica
country: Poland
facility: DC-MED
city: Braga
country: Portugal
facility: Hospital de Braga
city: Guimarães
country: Portugal
facility: Hospital da Senhora da Oliveira Guimarães
city: Lisboa
country: Portugal
facility: Hospital da Luz
city: Lisboa
country: Portugal
facility: Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria
city: Santa Maria Da Feira
country: Portugal
facility: Centro Hospitalar de Entre o Douro e Vouga, E.P.E - Hospital de São Sebastião
city: Viana Do Castelo
country: Portugal
facility: Centro Hospitalar do Alto Minho - Unidade Local de Saúde do Alto Minho, EPE
city: Bucharest
country: Romania
facility: Spitalul de Oncologie Monza
city: Bucuresti
country: Romania
facility: SC Centrul Medical Medicum SRL, Specialitatea Gastroenterologie
city: Bucuresti
country: Romania
facility: S.C Delta Health Care S.R.L
city: Bucuresti
country: Romania
facility: Spitalul Clinic Colentina
city: Cluj-Napoca
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Cluj Napoca
city: Craiova
country: Romania
facility: Centrul Medical Renasterea Craiova
city: Oradea
country: Romania
facility: S.C Pelican Impex S.R.L
city: Ploieşti
country: Romania
facility: S.C Centrul Medical Valahia S.R.L
city: Belgrade
country: Serbia
facility: Clinical Center " Dr Dragisa Misovic Dedinje"
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Zvezdara
city: Belgrade
country: Serbia
facility: Clinical Hospital Center "Bezanijska kosa
city: Kragujevac
country: Serbia
facility: University Clinical Center Kragujevac
city: Subotica
country: Serbia
facility: General Hospital Subotica
city: Zrenjanin
country: Serbia
facility: General Hospital "Djordje Joanovic"
city: Banská Bystrica
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta
city: Bratislava
country: Slovakia
facility: Cliniq s.r.o.
city: Košice
country: Slovakia
facility: Endomed, s.r.o.
city: Nitra
country: Slovakia
facility: KM Management spol. s r.o.
city: Nitra
country: Slovakia
facility: Fakultna nemocnica Nitra
city: Prešov
country: Slovakia
facility: Gastro I, s.r.o.
city: Prešov
country: Slovakia
facility: Gastro LM s.r.o.
city: Šahy
country: Slovakia
facility: Accout Center s.r.o.
city: Córdoba
country: Spain
facility: Hospital Universitario Reina Sofia
state: Cordoba
city: Ferrol
country: Spain
facility: Complejo Hospitalario Universitario de Ferrol
state: La Coruña
city: Santiago De Compostela
country: Spain
facility: Clinica Gaias - Santiago
state: La Coruña
city: Santiago De Compostela
country: Spain
facility: Complejo Hospitalario Universitario de Santiago
state: La Coruña
city: Las Palmas De Gran Canaria
country: Spain
facility: Hospital Universitario de Gran Canaria Dr. Negrin
state: Las Palmas
city: Fuenlabrada
country: Spain
facility: Hospital Universitario de Fuenlabrada
state: Madrid
city: Barcelona
country: Spain
facility: Centro Medico Teknon
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona
city: Girona
country: Spain
facility: Hospital Universitari de Girona Dr Josep Trueta
city: Huelva
country: Spain
facility: Hospital General Juan Ramon Jimenez
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañon
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Pontevedra
country: Spain
facility: Hospital Montecelo
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia
city: Valencia
country: Spain
facility: Hospital Universitari i Politecnic La Fe
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet
city: Basel
country: Switzerland
facility: Clarunis - Universitäres Bauchzentrum Basel
city: Bern
country: Switzerland
facility: Inselspital - Universitaetsspital Bern
city: Bern
country: Switzerland
facility: Intesto Gastroenterologische Praxis, Crohn-Colitis-Zentrum Bern
city: Zuerich
country: Switzerland
facility: Universitaetsspital Zuerich
city: Ankara
country: Turkey
facility: Gazi University Medical Faculty
city: Antalya
country: Turkey
facility: Antalya Training and Research Hospital
city: Istanbul
country: Turkey
facility: Koc University Hospital
city: Istanbul
country: Turkey
facility: Medicana Kadikoy Hospital
city: Istanbul
country: Turkey
facility: Acibadem Kozyatagi Hospital
city: İzmir
country: Turkey
facility: Ege University Medical Faculty
city: Kocaeli
country: Turkey
facility: Kocaeli Universitesi Tip Fakultesi
city: Malatya
country: Turkey
facility: Inonu University Gastroenterology
city: Mersin
country: Turkey
facility: Mersin University Medical Faculty
city: Cambridge
country: United Kingdom
facility: Addenbrooke's Hospital
state: Cambridgeshire
city: Exeter
country: United Kingdom
facility: Royal Devon and Exeter Hospital (Wonford)
state: Devon
city: London
country: United Kingdom
facility: Guy's Hospital
state: Greater London
city: London
country: United Kingdom
facility: King's College Hospital
state: Greater London
city: London
country: United Kingdom
facility: Hammersmith Hospital
state: Greater London
city: Bury
country: United Kingdom
facility: Bury Care Organisation
state: Greater Manchester
city: Harrow
country: United Kingdom
facility: St Mark's Hospital
state: Middlesex
city: Yeovil
country: United Kingdom
facility: Yeovil District Hospital
state: Somerset
city: Huddersfield
country: United Kingdom
facility: Huddersfield Royal Infirmary
state: West Yorkshire
city: Belfast
country: United Kingdom
facility: The Ulster Hospital
Study officials:
affiliation: UZ Leuven, Belgium
name: Severine Vermeire, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Mount Sinai Health System Digestive Disease Institute, New York USA
name: Bruce Sands, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: