Clinical trial NCT01941368: The Effects of β-Hydroxy-β-methylbutyrate Free Acid and High-Intensity Interval Training
Official title: The Effects of β-Hydroxy-β-methylbutyrate Free Acid Gel and High-Intensity Interval Training on Quadriceps Muscle Architecture and Quality, Neuromuscular Economy, and Metabolic Performance in Recreationally Trained Individuals
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Keywords: Performance
Aerobic Exercise
Lead sponsor: Metabolic Technologies Inc.
Sponsor class: INDUSTRY
First posted: 2013-09-13
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Objectives: 1) Determine the effect of 4-weeks of high intensity interval training (HIIT) and free acid form β-Hydroxy-β-methylbutyrate (HMB-FA) on VO2peak, lactate threshold, critical power, anaerobic working capacity and neuromuscular economy in a population of endurance trained individuals. 2) Determine the effect of 4-weeks of HIIT and HMB-FA on changes in skeletal muscle physiological cross-sectional area (PCSA=Volume/Fascicle length) and muscle quality (MQ=echo intensity) in the rectus femoris and vastus lateralis.

Subjects: Fifty males and females between the ages of 18 - 35 will be recruited to participate in this study. Subject will be randomized to one of three groups: a control group (CTL), an HIIT only group (HIIT) or a group which will take the amino acid metabolite HMB and perform HIIT (HMB-HIIT). Individuals assigned to CTL will undergo baseline testing. They will then be asked to continue their normal exercise routine for 4 weeks and will undergo post-testing after this time period.

Study Protocol: Two testing sessions, on nonconsecutive days, will occur at least 72 hours prior to the start of the training period. The same testing protocols will be repeated at the end of the 4-week training period. Testing protocols include performance testing (VO2peak, lactate threshold, critical power, anaerobic working capacity and neuromuscular economy) and anthropometric measures (physiological cross-sectional area and muscle quality). The training protocol for individuals in the experimental groups will consist of 4-weeks of high intensity interval training with three sessions per week on an electronically braked cycle ergometer. Individual work -loads will be calculated based on the outcomes from each participant's preliminary testing.


Eligibility criteria: Inclusion Criteria:

* Recreationally-trained individuals with a VO2peak\>40 ml∙kg-1∙min-1.
* Free of any physical limitations as determined by the Confidential Medical and Activity questionnaire and/or PAR-Q
* Between the ages of 18 and 35

Exclusion Criteria:

* Inability to perform physical exercise, as determined by the Confidential Medical and Activity questionnaire and/or PAR-Q
* Any chronic illness that causes continuous medical care

Primary outcomes:
measure: VO2peak/Ventilatory Threshold/fatigue threshold
timeFrame: Change from baseline after four weeks of high intensity interval training
Secondary outcomes:
measure: EMG Activity Assessment
timeFrame: Change from baseline after four weeks of high intensity interval training
Other outcomes:
measure: Ultrasonography
timeFrame: Change from baseline after four weeks of high intensity interval training
measure: Three-minute Critical Power test
timeFrame: Change from baseline four weeks of high intensity interval training
measure: Maximal Isometric Strength
timeFrame: Change from baseline after four weeks of high intensity interval training
Locations:
city: Orlando
country: United States
facility: University of Central Florida, Sport and Exercise Science
state: Florida
Study officials:
affiliation: University of Central Florida
name: Jeffery Stout, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Robinson EH 4th, Stout JR, Miramonti AA, Fukuda DH, Wang R, Townsend JR, Mangine GT, Fragala MS, Hoffman JR. High-intensity interval training and beta-hydroxy-beta-methylbutyric free acid improves aerobic power and metabolic thresholds. J Int Soc Sports Nutr. 2014 Apr 26;11:16. doi: 10.1186/1550-2783-11-16. eCollection 2014.