Clinical trial NCT04529122: A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test
Official title: A Registry to Collect Characteristics and Outcomes From Patients With Solid Tumors Profiled With a Next-Generation Sequencing Test (WAYFIND-R)
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Solid Tumours
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2020-08-27
Enrollment: 15000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male and Female adult participants who are diagnosed with solid tumour cancers (at any anatomical location) and at any stage of the disease who have undergone an NGS test.

Brief summary: WAYFIND-R is a registry that aims to capture high-quality real-world data linking next-generation sequencing, treatments and outcomes from cancer patients diagnosed with a solid tumour. The WAYFIND-R has three main overarching objectives: 1. To provide a platform to support the design and conduct of clinical and epidemiological research; 2. To develop an evidence-generation platform to better understand health outcomes and cancer care processes; and 3. To characterize the treatments and clinical course of solid tumor cancers in patients who have undergone NGS testing.


Eligibility criteria: Inclusion Criteria:

* Participant is an adult (according to the age of majority as defined by local regulations)
* Participant is currently diagnosed with any type of solid tumour cancer, at any stage of the disease, at the enrollment date (informed consent date)
* Participant has undergone NGS testing, no longer than 3 months prior to the enrollment date, irrespective of the availability of test results
* Informed consent has been obtained from the participant or legally authorized representative, as per local regulations

Exclusion Criteria:

-Participant has a prior or current diagnosis of haematological malignancy

Primary outcomes:
measure: Overall Survival
timeFrame: From date of registry entry until death, for up to 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Buenos Aires
country: Argentina
facility: Instituto Alexander Fleming
city: Buenos Aires
country: Argentina
facility: CEMIC
city: Graz
country: Austria
facility: Lkh-Univ. Klinikum Graz
city: Porto Alegre
country: Brazil
facility: Hospital Moinhos de Vento
state: Rio Grande Do Sul
city: Sao Paulo
country: Brazil
facility: Instituto do Cancer do Estado de Sao Paulo - ICESP
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Hospital Alemao Oswaldo Cruz
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: D'or Instituto de Pesquisa e Educação
city: São Paulo
country: Brazil
facility: Beneficencia Portuguesa de Sao Paulo
city: Calgary
country: Canada
facility: Alberta Health Services
state: Alberta
city: Ottawa
country: Canada
facility: The Ottawa Hospital - General Campus
state: Ontario
city: Las Condes
country: Chile
facility: Centro de Oncología de Precisión
city: Santiago
country: Chile
facility: Centro de Cancer Pontificie Universidad Catolica de Chile
city: Bogota, D.C.
country: Colombia
facility: Fundación CTIC - Centro de Tratamiento e Investigación sobre Cáncer Luis Carlos Sarmiento Angulo
city: Bogota
country: Colombia
facility: Fundacion Cardioinfantil
city: Bogota
country: Colombia
facility: Organizacion Sanitas Internacional
city: Cali
country: Colombia
facility: Fundacion Clinica Valle del Lili
city: Medellin
country: Colombia
facility: Instituto Cancerología Medellin
city: Medellin
country: Colombia
facility: Clinica ASTORGA
city: Cairo
country: Egypt
facility: International Medical Center
city: Tallinn
country: Estonia
facility: East Tallinn Central Hospital
city: Tallinn
country: Estonia
facility: North Estonia Medical Centre Foundation
city: Tartu
country: Estonia
facility: Tartu Uni Hospital
city: Amiens Cedex 1
country: France
facility: Chu Amiens - Picardie
city: Besancon
country: France
facility: Hopital Jean Minjoz
city: Bethune cedex
country: France
facility: Centre Hospitalier de Béthune-Beuvry
city: Brest
country: France
facility: Chu Brest - Hôpital Morvan
city: Caen
country: France
facility: Centre Francois Baclesse
city: Clermont Ferrand
country: France
facility: Centre Jean Perrin
city: Dijon
country: France
facility: Centre hospitalier universitaire Dijon-Bourgogne
city: Levallois-Perret
country: France
facility: Hôpital Franco-Britannique- Fondation Cognacq-Jay
city: Lille
country: France
facility: Centre Oscar Lambret
city: Lyon
country: France
facility: Centre Leon Berard
city: Marseille
country: France
facility: APHM
city: Marseille
country: France
facility: Hopital de La Timone - CHU de Marseille
city: Paris
country: France
facility: Institut Curie
city: Quimper
country: France
facility: CH de Cornouailles
city: Rennes
country: France
facility: Centre Eugene Marquis
city: Saint Etienne
country: France
facility: CHU Saint Etienne - Hôpital Nord
city: St Etienne
country: France
facility: Hôpital Privé de la Loire, Ramsay Saint Etienne
city: Toulon
country: France
facility: CHI de Toulon - Hôpital Sainte Musse
city: Villejuif CEDEX
country: France
facility: Gustave Roussy
city: Bad Saarow
country: Germany
facility: HELIOS Klinikum Bad Saarow
city: Berlin
country: Germany
facility: DRK Kliniken Berlin
city: Halle (Saale)
country: Germany
facility: Universitätsklinikum Halle (Saale)
city: Hamburg
country: Germany
facility: Asklepios Klinik Altona
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
city: Heilbronn
country: Germany
facility: SLK-Kliniken Heilbronn GmbH;Klinik für Innere Medizin III
city: Mönchengladbach
country: Germany
facility: Praxis für Hämatologie, Onkologie und Palliativmedizin
city: Reutlingen
country: Germany
facility: Klinikum am Steinenberg / Ermstalklinik
city: Stuttgart
country: Germany
facility: Katharinenhospital Stuttgart
city: Wesel
country: Germany
facility: Marien-Hospital Wesel
city: Asvestochori
country: Greece
facility: General Hospital "G.Papanikolaou"
city: Athens
country: Greece
facility: Henri Dunant Hospital
city: Athens
country: Greece
facility: Alexandras General Hospital of Athens
city: Faliro
country: Greece
facility: Metropolitan Hospital Fourth Oncology Clinic
city: Thessaloniki
country: Greece
facility: Bioclinic Thessaloniki
city: Kecskemét
country: Hungary
facility: Bács-Kiskun Vármegyei Oktatókórház
city: Pécs
country: Hungary
facility: Pécsi Tudományegyetem
city: New Delhi
country: India
facility: Max Super Speciality Hospital
state: Delhi
city: Bangalore
country: India
facility: Manipal Hospital
state: Karnataka
city: Banglore
country: India
facility: HealthCare Global Enterprises Limited
state: Karnataka
city: Mumbai
country: India
facility: Tata Memorial Hospital
state: Maharashtra
city: Mumbai
country: India
facility: MOC Cancer Care & Research Centre (Unit of Cellcure Cancer Centre Pvt Ltd)
state: Maharashtra
city: Thane
country: India
facility: Bhaktivedanta Hospital and research institute
state: Maharashtra
city: Chennai
country: India
facility: Apollo Hospitals
state: Tamil NADU
city: Hyderabad
country: India
facility: Indo-American Cancer Hospital & Research Center
state: Telangana
city: CO Offaly
country: Ireland
facility: Mid-Land Regional Hospital Tullamore
city: Dublin
country: Ireland
facility: Adelaide & Meath Hospital, Dublin, Incorporating the National Children's Hospital
city: Dublin
country: Ireland
facility: St Vincent'S Uni Hospital
city: Dublin
country: Ireland
facility: St James's Hospital
city: Dublin
country: Ireland
facility: Beacon Hospital
city: Jerusalem
country: Israel
facility: Hadassah University Hospital - Ein Kerem
city: Tel Aviv
country: Israel
facility: Sourasky / Ichilov Hospital
city: Beirut
country: Lebanon
facility: American University of Beirut - Medical Center
city: Beirut
country: Lebanon
facility: Hotel Dieu de France
city: Saida
country: Lebanon
facility: Hammoud Hospital
city: Ciudad de México
country: Mexico
facility: ONCARE Viaducto Napoles
state: Mexico CITY (federal District)
city: Puebla
country: Mexico
facility: Clínica Integral Internacional de Oncología S de RL de CV
state: Mexico CITY (federal District)
city: Mexico City
country: Mexico
facility: The American British Cowdray Hospital/ Hospital Abc
city: Cebu City
country: Philippines
facility: Cebu Doctors' University Hospital
city: Davao City
country: Philippines
facility: Metro Davao Medical and Research Center
city: Quezon City
country: Philippines
facility: St Lukes Medical Center
city: Warszawa
country: Poland
facility: Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie
city: Lisboa
country: Portugal
facility: Hospital da Luz
city: Porto
country: Portugal
facility: Hospital CUF Porto
city: Porto
country: Portugal
facility: IPO do Porto
city: Riyadh
country: Saudi Arabia
facility: National Guard King Abdulaziz Medical City
city: Belgrade
country: Serbia
facility: University Hospital Medical Center Bezanijska kosa
city: Belgrade
country: Serbia
facility: Oncomed-System
city: Belgrade
country: Serbia
facility: SIRIUS Medical
city: Belgrade
country: Serbia
facility: Special hospital for internal diseases Vesalius
city: Sremska Kamenica
country: Serbia
facility: Oncology Institute of Vojvodina
city: Bratislava
country: Slovakia
facility: Narodny Onkologicky Ustav
city: Golnik
country: Slovenia
facility: University Clinic Golnik
city: Ljubljana
country: Slovenia
facility: Institute of Oncology Ljubljana
city: Johannesburg
country: South Africa
facility: Medical Oncology Centre of Rosebank
city: Pretoria
country: South Africa
facility: Wilgers Oncology Centre
city: Palma De Mallorca
country: Spain
facility: Hospital Universitario Son Espases
state: Islas Baleares
city: Pamplona
country: Spain
facility: Clinica Universitaria de Navarra
state: Navarra
city: Jaen
country: Spain
facility: Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico
city: Malaga
country: Spain
facility: Hospital Clinico Universitario Virgen de la Victoria;Servicio de Oncologia
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet
city: Kaohisung
country: Taiwan
facility: Chang Gung Medical Foundation - Kaohsiung
city: Taipei City
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taoyuan County
country: Taiwan
facility: Chung Gung Memorial Hospital
city: Bangkok
country: Thailand
facility: Chulalongkorn Hospital
city: Bangkok
country: Thailand
facility: Faculty of Med. Siriraj Hosp.
city: Istanbul
country: Turkey
facility: Medicana International Zincirlikuyu Hospital
state: Enter Text
city: Ankara
country: Turkey
facility: Memorial Ankara Hastanesi
city: Edirne
country: Turkey
facility: Trakya University Medical Faculty
city: Istanbul
country: Turkey
facility: Ba?c?lar Medipol Mega Üniversite Hastanesi
city: Istanbul
country: Turkey
facility: Medicana International Atasehir Hospital
city: Izmir
country: Turkey
facility: Medicana International Izmir Hospital
city: Sar?yer/?stanbul
country: Turkey
facility: Ac?badem Maslak Hastanesi Büyükdere
city: Seyhan/Adana
country: Turkey
facility: Ac?badem Adana Hospital, Oncology Department
city: Dubai
country: United Arab Emirates
facility: Mediclinic City Hospital
city: Blackpool
country: United Kingdom
facility: Blackpool Victoria Hospital
city: Bristol
country: United Kingdom
facility: Bristol Haematology and Oncology centre
city: Eastbourne
country: United Kingdom
facility: Royal Sussex County Hospital
city: Exeter
country: United Kingdom
facility: Royal Devon & Exeter Hospital
city: Gloucester
country: United Kingdom
facility: Gloucestershire Royal Hospital
city: Guildford
country: United Kingdom
facility: Royal Surrey County Hospital
city: London
country: United Kingdom
facility: St Georges University Hospitals NHS Foundation Trust
city: New Castle Upon Tyne
country: United Kingdom
facility: Freeman Hospital
city: Northwood
country: United Kingdom
facility: Mount Vernon Hospital
city: Somerset
country: United Kingdom
facility: Musgrove Park Hospital
city: Sutton in Ashfield
country: United Kingdom
facility: Kings Mill Hospital
city: Torquay
country: United Kingdom
facility: Torbay Hospital
city: Hanoi
country: Vietnam
facility: Hanoi Oncology Hospital
city: Hanoi
country: Vietnam
facility: K hospital
city: Ho Chi Minh City
country: Vietnam
facility: Ho Chi Minh City Oncology Hospital
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References: