Clinical trial NCT02317120: BRCA1 and BRCA2 Mutation in Romanian Population: a Study of Genotype - Phenotype Correlation at Diagnosis With Prospective Disease Outcome and Survival
Official title: BRCA1 and BRCA2 Mutation in Romanian Population: a Study of Genotype - Phenotype Correlation at Diagnosis With Prospective Disease Outcome and Survival
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: To Determine the Prevalence, Penetrance of BRCA1 and BRCA2 Mutations in Romanian Womens With Breast or Ovarian Cancer
Lead sponsor: Prof. Dr. I. Chiricuta Institute of Oncology
Sponsor class: OTHER
Collaborators: name: Iuliu Hatieganu University of Medicine and Pharmacy
First posted: 2014-12-15
Enrollment: 250
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Womens who have been diagnosed with breast/ovarian cancer , carriers of a high risk of gBRCA mutations based on prespecified inclusion criterias

Brief summary: Primary objective To determine BRCA1 and BRCA2 variants in 250 Romanian women with breast/ovarian cancer selected for likeliness to harbor germline mutations in these genes by specific criteria for high-risk status including age at disease onset.

Secondary objective Considering the fact that BRCA testing is not a routine procedure in Romania and mutation prevalence varies in different populations, we intend to look for the founder mutation in our population, running full BRCA genes sequencing to a representative population sample. This would allow a more targeted approach to real-life practice and would ensure personalized solutions for every patient in need.


Eligibility criteria: Inclusion Criteria:

Categories of patients to be recruited for complete sequencing of all BRCA1 and BRCA2 exons are subjects who have been diagnosed with breast or ovarion cancer and who are:

1)40 years of age or younger 2)Triple negative breast cancer diagnosed before 50 years of age 3)Male with breast cancer 4)Bilateral breast cancer, first tumor diagnosed before 50 years of age 5)2) + 50 years of age or younger with at least one (first degree) relative diagnosed with breast cancer at 50 years of age or younger or a first degree relative with ovarian cancer 6)of any age with 2 or more relatives with breast cancer 7)of any age with 2 or more relatives with ovarian cancer 8)of any age with a personal history of ovarian cancer, tuba or peritoneal carcinoma 9)Two patients in same branch of the family, Prostate ca \< 60 yr and 1st degree relative with BC \< 50 yr 10)Two or more 1st and 2nd degree relatives of a patient with breast cancer, at least one of them \<50 yr 11)of any age with a family history of male breast cancer or are at increased risk of having a BRCA mutation based on BRCAPRO or Tyrer-Cuzick models

Exclusion Criteria:

-

Primary outcomes:
measure: BRCA1 and BRCA2 variants prevalence and penetrance at Romanian women with breast/ovarian cancer selected for likeliness to harbor germline mutations
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cluj Napoca
country: Romania
facility: ChiricutaIO
Study officials:
affiliation: ESMO
name: Alexandru Eniu, MD,PhD
role: STUDY_DIRECTOR
References: