louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06571435: Relationship Between Modified Closed Kinetic Chain Upper Extremity Stability Test and Shoulder Endurance Test in Young Active and Sedentary Individuals
Official title: Relationship Between Modified Closed Kinetic Chain Upper Extremity Stability Test and Shoulder Endurance Test in Young Active and Sedentary Individuals
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Healthy
Keywords: endurance
shoulder
stability
young adult
sedentary
Lead sponsor: Acibadem University
Sponsor class: OTHER
Collaborators: name: Biruni University
First posted: 2024-08-26
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Healthy young adults aged between 18-25 years old

Brief summary: This study is planned to examine the relationship between Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) performance with Posterior Shoulder Endurance Test in healthy young adults. Both tests are frequently used in athletes, but their use in sedentary people is not common in the literature. The feasibility of using these tests in sedentary people is not clear.


Eligibility criteria: Inclusion Criteria:

* Healthy young adults aged between 18-25
* Volunteered for the study

Exclusion Criteria:

* Participants who had any injury on upper extremity in last 6 months
* Participants with moderately active results on IPAQ-SF

Primary outcomes:
measure: Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) Performance
timeFrame: 4 weeks
measure: Posterior Shoulder Endurance Test Performance
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Acibadem University
state: Ataşehir
Study officials:
References:
Clinical trial NCT02501135: A Retrospective Investigation of Local Anesthetic Concentrations in Femoral Nerve Block
Official title: A Retrospective Investigation of Safety and Efficacy From Increasing Concentrations of Local Anesthetic in Pediatric Femoral Nerve Blocks
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Pain
Keywords: Femoral nerve blocks
children
knee and thigh surgery
Lead sponsor: Nationwide Children's Hospital
Sponsor class: OTHER
First posted: 2015-07-17
Enrollment: 281
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who have undergone anesthesia and received a femoral nerve block at Nationwide Children'ts Hospital from 2010-2015 utilizing our EMR - PICIS.

Brief summary: The purpose of this study is to retrospectively compare perioperative pain relief and safety in pediatric patients who have received a femoral nerve block with varying concentrations of local anesthetic.


Eligibility criteria: Inclusion Criteria:

* ASA physical status I or II
* Age \< or equal to 18 years of age at time of femoral nerve block
* Femoral nerve block performed from 2010-2015

Exclusion Criteria:

* ASA physical status \> II
* Co-morbid diseases (cardiac, pulmonary, neurological disease)
* Use of adjunctive medications in femoral nerve block (except for epinephrine), such as dexamethasone

Primary outcomes:
measure: Concentration of Local Anesthetic Injected for Femoral Nerve Block
timeFrame: length of surgery
measure: Total mg of Local Anesthetic Injected for Femoral Nerve Block
timeFrame: length of surgery
measure: Intraoperative Tylenol Administered
timeFrame: length of surgery
measure: Post-operative Opioids Administered
timeFrame: in PACU (1 hr post-op)
Secondary outcomes:
measure: Time to Discharge From PACU
timeFrame: Conclusion of surgery until admission to assigned unit or to phase, an expected average of 1 hour
measure: Post-operative Pain Scale Using FLACC
timeFrame: 1 hour post-op
measure: Post-operative Pain Scale Using VAS
timeFrame: 1 hour post-op
Other outcomes:
Locations:
Study officials:
affiliation: Nationwide Children's Hospital
name: Giorgio Veneziano, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05990335: Boost Study 21270 (Cognition)
Official title: Mobile Software Application Intervention Including Cognitive Tasks
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Cognitive Function Abnormal
Keywords: Cognition
Lead sponsor: NXTech
Sponsor class: INDUSTRY
Collaborators: name: Kansas State University
name: National Institutes of Health (NIH)
name: National Institute on Drug Abuse (NIDA)
First posted: 2023-08-14
Enrollment: 124
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Intervention model description: Between subjects and within subjects mixed design, reflecting major variables of high/low group intervention/control.
Primary purpose: BASIC_SCIENCE

Brief summary: This study is designed to to test the technical feasibility of encouraging interaction with a mobile smartphone software package (mHealth app) for training aspects of executive function and cognition.

Detailed description: The purpose of this human subjects study is to test the technical feasibility of interaction with a mobile smartphone software package (mHealth app) for training in aspects of executive function and cognition. The study participants are healthy subjects recruited online, with consent secured at the time of screening, and with enrollees assigned to High or Low groups on the basis of initial screening task scores. Subjects are requested to participate in directed interaction activities for up to 8 weeks, with measures primarily evaluating feasibility of MHealth app package task completion and secondarily evaluating the cognitive effect of activities.

Eligibility criteria: Inclusion Criteria:

* Age 18 years and above
* Fluent in English
* Resides in the United States
* Score on prescreen task is in 25% quartile
* Familiar with smartphone device app installation and device usage
* Possesses a compatible smartphone

Exclusion Criteria:

None

Primary outcomes:
measure: Task Completion Rate
timeFrame: At 8 weeks
Secondary outcomes:
measure: Change in Task Performance
timeFrame: At 8 weeks
Other outcomes:
Locations:
city: Manhattan
country: United States
facility: Kansas State DPS
state: Kansas
Study officials:
affiliation: Kansas State
name: Travis Smith
role: STUDY_DIRECTOR
References:
Clinical trial NCT03379935: Radial Head Arthroplasty A Clinical and Radiological Comparison of Monopolar and Bipolar Radial Head Arthroplasty
Official title: Radial Head Arthroplasty: A Clinical and Radiological Comparison of Monopolar and Bipolar Radial Head Arthroplasty
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Radial Head Fracture
Elbow Fracture
Arthroplasty Complications
Lead sponsor: Sundsvall Hospital
Sponsor class: OTHER
First posted: 2017-12-20
Enrollment: 27
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients treated with a radial head arthroplasty are included in the study. All patients were asked to participate in the follow-up during 2017.

Brief summary: Fractures of the radial head are among the most common fractures in the elbow and represent one-third of all elbow fractures.This retrospective cohort study was performed between 2004 and 2014 at Sundsvall and Umeå University hospital, Sweden. All patients who were operated on between 2004 and 2014 with a radial head arthroplasty for an acute or sequelae due to a caput radii fracture.The aim of this study is to evaluate clinical or radiological differences between patients treated with a unipolar or bipolar radial head arthroplasty.


Eligibility criteria: Inclusion Criteria:

* All patients treated with a radial head arthroplasty during the study period.

Exclusion Criteria:

* None

Primary outcomes:
measure: QuickDASH
timeFrame: 2-16 years postoperatively
Secondary outcomes:
measure: Pain
timeFrame: 2-16 years postoperatively
measure: Range of motion
timeFrame: 2-16 years postoperatively
measure: Reoperation
timeFrame: 2-16 years postoperatively
measure: Radiographic evaluation
timeFrame: 2-16 years postoperatively
Other outcomes:
Locations:
Study officials:
affiliation: Umeå University
name: Bakir Kadum, M.D, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Heijink A, Kodde IF, Mulder PGH, Veltman ES, Kaas L, van den Bekerom MPJ, Eygendaal D. Radial Head Arthroplasty: A Systematic Review. JBJS Rev. 2016 Oct 18;4(10):e3. doi: 10.2106/JBJS.RVW.15.00095.
citation: Heijink A, Kodde IF, Mulder PGH, Van Dijk CN, Eygendaal D. Cemented bipolar radial head arthroplasty: midterm follow-up results. J Shoulder Elbow Surg. 2016 Nov;25(11):1829-1838. doi: 10.1016/j.jse.2016.05.017. Epub 2016 Aug 9.
citation: Duckworth AD, Wickramasinghe NR, Clement ND, Court-Brown CM, McQueen MM. Radial head replacement for acute complex fractures: what are the rate and risks factors for revision or removal? Clin Orthop Relat Res. 2014 Jul;472(7):2136-43. doi: 10.1007/s11999-014-3516-y.
Clinical trial NCT04226235: Acute Effects of Vinyasa Yoga on Vascular Function
Official title: Acute Effects of Yoga on Arterial Stiffness, Wave Reflection, and Blood Markers in Normotensive and Hypertensive Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Lead sponsor: Texas State University
Sponsor class: OTHER
First posted: 2020-01-13
Enrollment: 30
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The purpose of this investigation was to determine the acute effects of vinyasa yoga on arterial stiffness, wave reflection, and blood markers in normo- and hyper-tensive adults. To address this aim, fifteen normotensive adults and 15 adults with elevated blood pressure or stage 1 hypertension with a minimum of 3 months of yoga practice experience were enrolled. Carotid-femoral pulse wave velocity (cf-PWV), augmentation index (AIx), lipid profile, and glucose concentrations were assessed at baseline and immediately following a 1-hour vinyasa yoga session.


Eligibility criteria: Inclusion Criteria:

* Having normal (systolic blood pressure \<120 mm Hg with a diastolic \<80 mm Hg) or elevated blood pressure (systolic blood pressure 120-129 mm Hg) or stage 1 hypertension (systolic blood pressure 130-139 mm Hg or a diastolic blood pressure 80-89 mm Hg).
* Must have had at least 3 months of prior yoga experience.

Exclusion Criteria:

* A history of cardiovascular disease or cardiac events, pregnancy, infection within the last 4 weeks, chronic obstructive pulmonary disease (COPD), endocrine or renal disease, metabolic disorders, or debilitating muscular, joint and bone injury.

Primary outcomes:
measure: Arterial stiffness
timeFrame: Once before the yoga session
measure: Arterial stiffness
timeFrame: Once immediately after the 1-hour yoga session
measure: Wave reflection
timeFrame: Once before the yoga session
measure: Wave reflection
timeFrame: Once immediately after the 1-hour yoga session
Secondary outcomes:
measure: Lipid profile
timeFrame: Once before the yoga session
measure: Lipid profile
timeFrame: Once immediately after the 1-hour yoga session
Other outcomes:
Locations:
city: San Marcos
country: United States
facility: Texas State University
state: Texas
Study officials:
References:
Clinical trial NCT02339935: Improving Hospitalizations for Children With ASD
Official title: Improving Hospitalizations for Children With ASD: Testing the Cost and Clinical Efficacy of Integrated Behavioral Intervention
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Autism Spectrum Disorder
Autistic Disorder
Keywords: Autism Spectrum Disorder
Autism
Lead sponsor: Vanderbilt University
Sponsor class: OTHER
First posted: 2015-01-16
Enrollment: 36
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study aims to implement and test a specific brief Applied Behavior Analysis model for assessing and responding to severe challenging behavior during acute medical and behavioral hospitalization for children with ASD. The investigators will evaluate the impact of this program by conducting a randomized trial across both medical and psychiatric hospital settings.


Eligibility criteria: Inclusion Criteria:

* documented diagnosis of an ASD based on clinical DSM-5 diagnostic criteria assessed by attending psychiatrist
* the presence of a significant challenging behaviors (e.g., aggression, property destruction, self-injury, elopement)
* admission to the VPH or medical floors
* individual and caregiver agreement to participate and ability to provide informed consent (and assent).

Exclusion Criteria:

* None

Primary outcomes:
measure: Aberrant Behavior Checklist
timeFrame: Change from Baseline ABC at Hospital Discharge (an expected average of 42 days) and 3-Months Post-Discharge
measure: Decrease in Length of Hospitalization
timeFrame: Participants will be followed from admission to discharge, an expected average of 42 days
Secondary outcomes:
measure: Clinical Global Impression Scales of Severity
timeFrame: Baseline and Day of Patient's Discharge (an expected average of 42 days from admission)
measure: Blinded Observational Ratings
timeFrame: Participants will be followed for duration of hospital stay, an expected average of 42 days
measure: Physician/Nurse/Family Perception of Care
timeFrame: Day of Patient's Discharge (an expected average of 42 days from admission)
Other outcomes:
Locations:
city: Nashville
country: United States
facility: Vanderbilt University Medical Center - MEND Clinic
state: Tennessee
Study officials:
affiliation: MEND Clinic - Director
name: Kevin Sanders, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Sanders K, Staubitz J, Juarez AP, Marler S, Browning W, McDonnell E, Altstein L, Macklin EA, Warren Z. Addressing Challenging Behavior During Hospitalizations for Children with Autism: A Pilot Applied Behavior Analysis Randomized Controlled Trial. Autism Res. 2020 Jul;13(7):1072-1078. doi: 10.1002/aur.2308. Epub 2020 Apr 23.
Clinical trial NCT05097235: Type 3 Predictive Observational Study for Sensory Profiles in Central Sensitization in Low Back Pain Population.
Official title: Type III PROGRESS Framework for Prognosis Research: Building Prognostic Models for Sensory Profiles in the Development of Central Sensitisation in the Chronic Low Back Pain Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sensory Profiles, Nociplastic Pain, Low Back Pain
Keywords: sensory profiles, central sensitization, low back pain.
Lead sponsor: Vrije Universiteit Brussel
Sponsor class: OTHER
First posted: 2021-10-28
Enrollment: 114
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: -primary physiotherapy practices in the Netherlands.

Brief summary: This study conducts prognostic research to develop, validate, and evaluate the predictive role of sensory profiles in the development of sensory profiles over time. Therefore, a type 3 prognostic model research will be conducted in the low back pain population.

Detailed description: This is a longitudinal multi-centre prospective cohort study design with two measurements.The STROBE statement is used as guideline and the results are reported according to the TRIPOD, and REMARK checklists. The study is a type III prognostic model research study, following the PROGRESS framework to assess the outcome by the development, validation, and evaluation of the impact of incorporating single or multiple prognostic factors, and their prognostic value at baseline in the development of CS over a period of 12 weeks.

Eligibility criteria: Inclusion Criteria:

* patients with acute LBP (\< six weeks)
* with or without radiating pain
* aged 18 to 60 years
* a pain-free episode for at least 12 weeks before the onset of their current back pain.
* be able to read and understand the Dutch language.

Exclusion Criteria:

* any specific cause of low back pain

Primary outcomes:
measure: Central Sensitization Inventory
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Zwolle
country: Netherlands
facility: Fysiomobilae
state: Overijssel
Study officials:
affiliation: Vrije Universiteit Brussel, Brussels, Belgium
name: Aldo Scafoglieri, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03421158: Non-pharmacological Analgesic Effects on Term Newborns
Official title: Comparing the Analgesic Effects of Four Non-pharmacological Interventions on Term Newborns Undergoing Heel Lance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain
Breast Feeding
Keywords: neonates
Non-pharmacological
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2018-02-05
Enrollment: 236
Sex: ALL
Minimum age (years): 24
Maximum age (years): 48
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the analgesic effects of four non-pharmacological interventions: skin-to-skin contact, breastfeeding, oral sucrose and nonnutritive sucking in newborns receiving a heel lance procedure.

Detailed description: This is an randomized control clinical study. study population is healthy term newborns.Patients were identified by chart review and consent was received by nurse researcher. Newborns were randomized into either the control group who received no pain intervention or the intervention group who received one of four non-pharmacological pain interventions: skin to skin contact, breastfeeding, oral sucrose, and nonnutritive sucking.

A heel lance for newborn screen blood sampling was selected as a study procedure and performed by a hospital technician following standard protocol. Pain scoring was assessed by two research nurses after the hell lance and through the procedure. Neonatal Pain, Agitation and Sedation Scale (NPASS) was selected as a pain assessment tool for this study.

The average pain score from two research nurses were used for statistical analysis.

Eligibility criteria: Inclusion Criteria:

* Gestational Age 38-40
* 2.5-4.0kg
* 24-48hours of age
* Receiving heel lance procedure
* Apgar\>7 at birth
* NPASS\<3 at time of heel lance

Exclusion Criteria:

* Prior heel lance procedure
* birth trauma
* forceps or vacuum delivery
* maternal drug abuse during delivery

Primary outcomes:
measure: Decrease in Neonatal Pain, Agitation and Sedation Scale (NPASS) scores for newborns receiving non-pharmacologic interventions
timeFrame: 12 month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Stanford University
name: Jie Chang, BSN,MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00005258: Family Study of Congenital Cardiovascular Malformations
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Diseases
Defect, Congenital Heart
Heart Diseases
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Sponsor class: NIH
First posted: 2000-05-26
Sex: MALE
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: To determine genetic mechanisms responsible for congenital cardiovascular malformations.

Detailed description: BACKGROUND:

Congenital cardiovascular malformations are a major cause of infant mortality in the United States. In 1985, six defects -- hypoplastic left heart, tetralogy of Fallot, truncus arteriosus, transposition of the great arteries, endocardial cushion defect, and ventricular septal defect -- were among the fifteen most frequent causes of premature death due to congenital malformations, accounting for 109,063 years of life lost. This loss of productive life continues in spite of major advances in medical and surgical treatment of congenital cardiovascular malformations. Even as successful treatment modalities are developed, the survival to reproductive years without improved understanding of genetic risks produces additional unanswered questions.

DESIGN NARRATIVE:

Clinical assessment of cases and controls included medical history, pedigree construction, complete evaluation by a pediatric cardiologist, and two-dimensional and Doppler echocardiography. First degree relatives of cases and controls underwent clinical-echocardiographic evaluation also. The distribution of cardiac defects for all pedigrees within and among the proband group was delineated. The frequencies of heart defects were compared within and among pedigrees of cases and controls. Regressive logistic models of genetic determinants for the malformations were tested. The three participating clinical centers included University of Maryland at Baltimore, the Johns Hopkins Hospital, and the University of Rochester in Rochester, New York.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Eligibility criteria: No eligibility criteria

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03601858: Descriptive Epidemiology of a Specialized Consultation on ADHD in Adults at the Strasbourg University Hospital
Official title: Descriptive Epidemiology of a Specialized Consultation on Attention Deficit Hyperactivity Disorder in Adults at the Strasbourg University Hospital, and Evolution Analysis at One Year
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Attention Deficit and Hyperactivity Disorder
Keywords: Attention deficit
hyperactivity disorder
Adult
Epidemiology
Evolution
treatment
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2018-07-26
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient Having a specialized consultation about ADHD in adults in the psychiatric service of the Strasbourg University Hospital

Brief summary: The main objective of this study is to carry out a descriptive study of the clinical and demographic characteristics of patients having consulted for a specialized opinion about ADHD in adults of the psychiatric service of the Strasbourg University Hospital.

The characteristics of patients were collected during the first consultation, by the psychiatrist, and analyzed retrospectively.

The secondary objective is to evaluate the evolution at one year in terms of follow-up, maintenance under medical treatment and perceived effects of it.

The patients who had a prescription for pharmacological treatment of ADHD were contacted between 9 and 15 months after the first consultation and responded to a questionnaire assessing the evolution.


Eligibility criteria: Inclusion Criteria:

* Age \> 18
* Having a specialized consultation about ADHD in adults in the psychiatric service of the Strasbourg University Hospital
* Agree with the use of medical files from the consultation for medical research

Exclusion Criteria:

* Disgree with the use of medical files from the consultation for medical research

Primary outcomes:
measure: Hyperactivity Disorder
timeFrame: Between 9 and 15 months after the first consultation, contact of patients and collection of data for the evolution at one year analyze
Secondary outcomes:
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: Service de Psychiatrie II
Study officials:
References: