Clinical trial NCT05405153: Translation of Parkinson's Disease Questionnaire -8 in Urdu Language
Official title: Urdu Version of Parkinson's Disease Questionnaire-8. A Cross-cultural Validity and Reliability Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Parkinson Disease
Keywords: PDQ-8, Parkinson's disease, validate .
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2022-06-06
Enrollment: 50
Sex: ALL
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Parkinson disease

Brief summary: Cross cultural analytical study to translate Parkinson's disease questionnaire-8 in Urdu language. Along with the translated version by evaluating its validity and reliability among the patients of Parkinson's disease. No such study has been previously conducted in Pakistan which translate this questionnaire in

Urdu and follows the proper cross- culture adaptation. Condition or disease:

Parkinson's disease. Convenient sampling technique would be used

Detailed description: Parkinson's Disease Questionnaire-8 (PDQ-8) is the brief version of PDQ-39 formulated to reduce the respondent burden and for convenient use in clinical settings in patients of Parkinson's disease. (PDQ-8) is the patient reported outcome measure constructed by taking one question from each of the eight domains of PDQ-39 (mobility, activities of daily living, emotional well-being, stigma, social support, cognition, communication, and bodily discomfort. PDQ-8 will be translated into Urdu language by Beaton et al guidelines for cross cultural adaptation of tool. The validity and reliability of Urdu version of PDQ-8 will be evaluated by calculating Cronbach's alpha, intra-class correlation coefficient and Pearson/spearman rank correlation co-efficient.

Continuous variables will be shown by mean and standard deviation and the categories will be demonstrated in frequency and percentage. Factor structure of the PDQ-8 will be extracted using exploratory factor analysis (EFA), utilizing principal component analysis with varimax rotation.

Eligibility criteria: Inclusion Criteria:

* Age 40-65 years
* Both genders
* Patients with diagnosed Idiopathic Parkinson's disease (IPD) by neurophysician
* Patient able to read Urdu Language. Patients who can participate in community, patients with cognitive issue, Patients with MMSE more than 24 will be included

Exclusion Criteria:

* Patients with any other neurological issue
* Patients who undergo brain surgery

Primary outcomes:
measure: Parkinson's disease questionnaire (PDQ-8)
timeFrame: 8 months
Secondary outcomes:
measure: Reliability of translated versions of PDQ-8
timeFrame: 8 months
measure: Validity of translated versions of PDQ-8
timeFrame: 8 months
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Lahore
state: Punjab
Study officials:
affiliation: Riphah International University
name: Tehreem Mukhtar, MS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Zhan A, Mohan S, Tarolli C, Schneider RB, Adams JL, Sharma S, Elson MJ, Spear KL, Glidden AM, Little MA, Terzis A, Dorsey ER, Saria S. Using Smartphones and Machine Learning to Quantify Parkinson Disease Severity: The Mobile Parkinson Disease Score. JAMA Neurol. 2018 Jul 1;75(7):876-880. doi: 10.1001/jamaneurol.2018.0809.
citation: Ellis TD, Cavanaugh JT, Earhart GM, Ford MP, Foreman KB, Thackeray A, Thiese MS, Dibble LE. Identifying clinical measures that most accurately reflect the progression of disability in Parkinson disease. Parkinsonism Relat Disord. 2016 Apr;25:65-71. doi: 10.1016/j.parkreldis.2016.02.006. Epub 2016 Feb 2.