Clinical trial NCT04204746: The Affecting Factors on Airway Temperature and Moisture
Official title: The Effects of Different Fresh Gas Flows and Different Anesthetics on Airway Temperature and Moisture in Patients Who Underwent General Anesthesia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: General Anesthesia
Keywords: general anesthesia
fresh gas
moisture
temperature
respiratory circuit
Lead sponsor: Selcuk University
Sponsor class: OTHER
First posted: 2019-12-19
Enrollment: 240
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who were aged between 18-65 years and underwent surgery with general anesthesia.

Brief summary: There is no literature information about the flow rate of fresh gas mixture (air+O2) in the patients who underwent general anesthesia. Different flow rates of fresh gas mixture are used in both the investigator's hospital and the experiences of the anesthesiologists. It is aimed to study the effects of different fresh gas flow rates on the rate of temperature and moisture of the airway of patients who underwent general anesthesia.

Detailed description: Under physiological conditions, inhaled air is heated and humidified as it passes through the nose and upper airways until reaching the alveoli. This mechanism is bypassed by endotracheal intubation. Ventilation with dry and cold compressed gases leads to loss of water and heat from the respiratory tract. Drying of the respiratory tract can lead to destruction of the cilia and mucous membranes, resulting in decreased mucociliary transport and increased concentration of secretions.There is no definitive literature on fresh gas mix (oxygen + air) flow rates in patients under general anesthesia. This study aimed to investigate whether two fresh gas flow rates routinely employed in the authors' practice affected airway temperature and humidity.

Eligibility criteria: Inclusion Criteria:

Patients aged 18-65 years underwent general anesthesia -

Exclusion Criteria:admitted to emergency and trauma, history of advanced cardiac disease, cigarette use ≥ 3 packet/day, pulmonary parenchymal disease such as malignancy or chronic obstructive pulmonary disease (COPD), history of thyroid disease, body mass index (BMI) greater than 30 kg/m2, alcohol and substance addiction, mentally deficiency, pregnancy or postpartum, fever and infection, drug use such that would influence thermoregulation such as vasodilators, hemorrhage \> 5 mL/kg, and patients who declined to participate.

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Primary outcomes:
measure: Affect of two fresh gas flow rates (3lt/ 6lt min) on patients' airway temperature and humidity.
timeFrame: 2016-2018
Secondary outcomes:
measure: Affect of different anesthetic gases (sevoflurane, desflurane) and drugs (propofol)on patients' airway temperature and humidity.
timeFrame: 2016-2018
Other outcomes:
Locations:
Study officials:
affiliation: Selcuk University
name: Ozkan Onal, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ozcan IG, Onal O, Ozdemirkan A, Saltali A, Sari M. Effects of different fresh gas flows and different anesthetics on airway temperature and humidity in surgical patients: a prospective observational study. Med Gas Res. 2022 Jul-Sep;12(3):83-90. doi: 10.4103/2045-9912.330691.