Clinical trial NCT06848686: Prevention Ambassadors: Intervention to Promote HIV Service Engagement in the Networks of SSP Clients
Official title: Prevention Ambassadors: an HIV Self-testing Intervention to Promote HIV Service Engagement in the Networks of SSP Clients
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: HIV
Lead sponsor: San Diego State University
Sponsor class: OTHER
Collaborators: name: University of California, San Diego
name: University of California, Riverside
name: Dap Health
name: National Institute on Drug Abuse (NIDA)
First posted: 2025-02-27
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: HIV testing and service uptake are infrequent among people who use drugs (PWUD) in the United States. In partnership with a community-based syringe service program (SSP), this project will develop the SSP-based "Prevention Ambassadors" (PA) intervention to promote HIV testing and service uptake among PWUD via the secondary distribution (i.e., peer delivery) of HIV self-testing (HIVST) kits with local HIV service information and referrals to HIV service navigation in the social networks of SSP clients (i.e., PWUD). The PA intervention will then be piloted to assess its preliminary effects, acceptability, and feasibility among PWUD in the Ending the HIV Epidemic priority jurisdiction of Riverside County, California.


Eligibility criteria: Index Participant Inclusion Criteria:

* Being greater than or equal to 18 years old
* Reporting drug use (past month)
* Having other people who use drugs (PWUD) in one's social network
* Being willing to talk about HIV testing and services with at least 2 PWUD in their networks and attempt to refer them to the study
* Speaking English fluently

Peer-Recruit Participant Inclusion Criteria:

* Being greater than or equal to 18 years old
* Reporting drug use (past 3 months)
* Being recruited by an index participant (evidenced by presenting the coupon used to recruit them)
* Speaking English fluently

Exclusion Criteria:

- Persons who participated in formative study activities related to the development of the PA intervention will not be eligible to participate.

Primary outcomes:
measure: HIV testing (past 3 months)
timeFrame: 3-month follow-up
measure: Linkage to PrEP/HIV care (past 3 months)
timeFrame: 3-month follow-up
measure: PrEP/ART uptake (past 3 months)
timeFrame: 3-month follow-up
Secondary outcomes:
measure: PA Acceptability (Peer-Recruit Participants)
timeFrame: Baseline
measure: PA Acceptability (Index Participants)
timeFrame: 3-month follow-up
measure: PA Feasibility (Peer-Recruit Participants)
timeFrame: Baseline
measure: PA Feasibility (Index Participants)
timeFrame: 3-month follow-up
Other outcomes:
Locations:
city: San Diego
country: United States
facility: San Diego State University
state: California
Study officials:
affiliation: San Diego State University
name: Heather A Pines
role: PRINCIPAL_INVESTIGATOR
affiliation: University of California, San Diego
name: Angela R Bazzi
role: PRINCIPAL_INVESTIGATOR
References: