louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01745835: Comparison Between 2L Coolprep® and Combination of 1L Coolprep® and Bisacodyl as Bowel Preparation
Official title: Comparison Between 2L Coolprep® and Combination of 1L Coolprep® and Bisacodyl as Bowel Preparation for Colonoscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Healthy Person
Bowel Preparation Before Colonoscopy
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2012-12-10
Enrollment: 196
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: comparison of the use of Colyte® (ascorbic acid mixed polyethylene glycol solution) in two-liter versus one-liter volume and pretreatment with bisacodyl for colonoscopy preparation.


Eligibility criteria: Inclusion Criteria:

* willing to consent/undergo necessary procedures
* between the age of 20 and 75 years
* healthy persons planning to have a colonoscopy

Exclusion Criteria:

* history of abdominal surgery except appendectomy
* inflammatory bowel disease
* clinically or laboratory-confirmed ileus (both functional and mechanical)
* malignancy
* clinically severe cerebrovascular, cardiovascular, kidney, liver or hematologic disease
* dementia, cognitive impairment
* the use of prokinetics, antispasmodics, antidiarrheal drugs, laxatives or neuroleptics in 2 weeks
* known sensitivity to the agents used
* Pregnancy, Lactating woman

Primary outcomes:
measure: Bowel cleansing scale
timeFrame: on the day of the colonoscopy
Secondary outcomes:
measure: Bowel cleansing scale of Right/Transverse/Left colon
timeFrame: on the day of the colonoscopy
Other outcomes:
measure: Patient's compliance
timeFrame: on the day of the colonoscopy
measure: Patient's acceptance
timeFrame: on the day of the colonoscopy
measure: Patient's satisfaction
timeFrame: on the day of the colonoscopy
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: City
Study officials:
affiliation: Seoul National University Hospital
name: Jong Pil Im, M.D.,Ph.D.
role: STUDY_DIRECTOR
References:
citation: Kwon JE, Lee JW, Im JP, Kim JW, Kim SH, Koh SJ, Kim BG, Lee KL, Kim SG, Kim JS, Jung HC. Comparable Efficacy of a 1-L PEG and Ascorbic Acid Solution Administered with Bisacodyl versus a 2-L PEG and Ascorbic Acid Solution for Colonoscopy Preparation: A Prospective, Randomized and Investigator-Blinded Trial. PLoS One. 2016 Sep 2;11(9):e0162051. doi: 10.1371/journal.pone.0162051. eCollection 2016.
Clinical trial NCT04341935: Effects of DPP4 Inhibition on COVID-19
Official title: Effects of DPP4 Inhibition on COVID-19 Patients With Type 2 Diabetes
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Coronavirus Infection
Type 2 Diabetes
Keywords: COVID-19
SARS-Cov 2
DPP4
Type 2 diabetes
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2020-04-10
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this research is to see if the DPP4 inhibitor linagliptin, an oral medication commonly used to treat type 2 diabetes,can help with diabetes control and reduce the severity of the COVID-19 infection


Eligibility criteria: Inclusion Criteria:

* Type 2 Diabetes Mellitus (T2DM) as per American Diabetes Association (ADA) guidelines
* Age ≥ 18
* Confirmed COVID-19
* Mild COVID-19 defined as any of the following: fever, malaise, cough, headache, sore throat, myalgia, nasal congestion, diarrhea
* Moderate COVID-19 is defined as \> 2 of the following in non-intubated patients: any symptom of mild disease, radiographic imaging (chest x-ray or lung ultrasound) with bilateral ground glass opacities or bilateral consolidations, SpO2 \<90% up to 5L Nasal Cannula (NC)
* No additional signs or symptoms of severe COVID-19.

Exclusion Criteria:

* Type 1 Diabetes Mellitus (T1DM) diabetes, as per ADA guidelines
* History of Diabetic Ketoacidosis (DKA)
* History of acute pancreatitis
* Chronic or Acute Renal Failure with Estimated Glomerular Filtration Rate (eGFR) \< 30 ml/min/1.73 m2

Exclusion Criteria:

T1DM diabetes, as per ADA guidelines, History of DKA, History of acute pancreatitis; Chronic or Acute Renal Failure with eGFR \< 30 ml/min/1.73 m2

Primary outcomes:
measure: Changes in Glucose Llevels
timeFrame: Baseline, up to 2 weeks
Secondary outcomes:
measure: Changes in SpO2 levels
timeFrame: Baseline, up to 2 weeks
measure: Changes in Interleukin 6 (IL6)
timeFrame: Baseline, up to 2 weeks
measure: Changes in chest structures
timeFrame: Baseline, up to 2 weeks
Other outcomes:
Locations:
city: Miami
country: United States
facility: University of Miami
state: Florida
Study officials:
affiliation: University of Miami
name: Gianluca Iacobellis, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Vankadari N, Wilce JA. Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. Emerg Microbes Infect. 2020 Mar 17;9(1):601-604. doi: 10.1080/22221751.2020.1739565. eCollection 2020.
citation: Iacobellis G. COVID-19 and diabetes: Can DPP4 inhibition play a role? Diabetes Res Clin Pract. 2020 Apr;162:108125. doi: 10.1016/j.diabres.2020.108125. Epub 2020 Mar 26. No abstract available.
Clinical trial NCT04885335: Evaluation of the Management of Acute Appendicitis Before Emergency Department in Children: a Prospective Study
Official title: Evaluation of the Management of Acute Appendicitis Before Emergency Department in Children: a Prospective Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Appendicitis
Lead sponsor: University Hospital, Limoges
Sponsor class: OTHER
First posted: 2021-05-13
Enrollment: 11
Sex: ALL
Minimum age (years): 0
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: -Child \<16 years with abdominal symptoms and consulting in the pediatric emergency department of Limoges University center.

Brief summary: Acute appendicitis is the first visceral surgical emergency in pediatrics with about 30,000 cases in children having been described in France.

It concerns 0.3% of children under 15 with a maximum frequency between 8 and 13 years of age. Acute appendicitis has a significant morbidity rate of 8% and a mortality rate under 0.1%.

10 to 25% of the children admitted to emergency rooms for abdominal pain have appendicitis.

In 20 to 30% of the cases, the initial symptoms are atypical, which explains the difficulty in diagnosing.

The purpose of our study is to evaluate the quality of general practitioners in the diagnosis of acute appendicitis, its severity and the diagnostic criteria used.

Furthermore, it is not as easy to evaluate pain or examine a complaint in children as it is in adults.

Appendicectomy is the treatment of choice for all acute appendicitis. The importance of early diagnosis and treatment is, therefore, essential. Many predictive diagnostic scores have been studied over the years. The Pediatric Appendicitis Score (PAS) using typical symptoms of acute appendicitis and biological items was published in 2002. Nowadays, it is still considered as a reference and has been validated by other studies.

Most of the patients suffering from abdominal pain first consult their general practitioner.


Eligibility criteria: Inclusion Criteria:

* Child \<16 years
* abdominal symptoms
* consulting in the pediatric emergency department of Limoges University center.

Exclusion Criteria:

* Child \>=16 years

Primary outcomes:
measure: PAS score
timeFrame: At 5 month
Secondary outcomes:
measure: Surgery for appendicitis
timeFrame: At 5 month
Other outcomes:
Locations:
city: Limoges
country: France
facility: Pediatric emergency department
Study officials:
References:
Clinical trial NCT01142635: Electromyographic (EMG) on the Anaesthesia Monitor
Official title: The Appearance of Electromyography on the Anaesthesia Monitor.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Anaesthesia
Keywords: Electroencephalogram
Electromyogram
Entropy Index
Bispectral Index
Neuromuscular blockade; rocuronium
Propofol
Intubation
Lead sponsor: Tampere University Hospital
Sponsor class: OTHER
First posted: 2010-06-11
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Intubation may induce electromyographic (EMG) activity, causing depth of anaesthesia monitors to show misleadingly high values. The investigators want to investigate whether this EMG activity can be visually seen on the anaesthesia monitor.

Detailed description: Patients are anaesthetized with target controlled infusion of propofol. To facilitate intubation, the patients are randomized to receive rocuronium either 0,6 mg/kg or 1,2 mg/kg. BIS, Entropy and the biosignal collected with the Entropy strip are collected on a computer. The visible biosignal on the anaesthesia monitor is recorded with a video camera. BIS, Entropy, biosignal and video clip of the anaesthesia monitor will be analyzed in detail.

Eligibility criteria: Inclusion Criteria:

* females giving informed consent
* age range 18-65 years
* elective surgery: gynaecological
* general anaesthesia
* ASA classification 1 or 2

Exclusion Criteria:

* pregnancy
* body mass index \> 30
* disease affecting CNS
* overuse of alcohol
* drug abuse
* unability to understand, read or use Finnish language

Primary outcomes:
measure: The behaviour of biosignal on the anaesthesia monitor
timeFrame: 30 minutes
Secondary outcomes:
measure: The behaviour of depth of anaesthesia indexes (BIS, SE, RE) during intubation
timeFrame: 30 min
Other outcomes:
Locations:
city: Tampere
country: Finland
facility: Tampere University Hospital
Study officials:
affiliation: Tampere University Hospital
name: Arvi Yli-Hankala, MD
role: STUDY_CHAIR
affiliation: Tampere University Hospital
name: Arvi Yli-Hankala, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03456635: Improving Perioperative Antimicrobial Prophylaxis by the Use of a Computerized Decision Support System
Official title: Improving Perioperative Antimicrobial Prophylaxis by the Use of a Computerized Decision Support System
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: NA
Conditions: Surgery
Keywords: antimicrobial
prophylaxys
CDSS
Lead sponsor: University Hospital, Geneva
Sponsor class: OTHER
Collaborators: name: Universidade do Porto
name: University of Sao Paulo
First posted: 2018-03-07
Enrollment: 20000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: quasi-experimental study Time-series analysis, with a non-equivalent variable prospective Quality Improvement project
Primary purpose: SUPPORTIVE_CARE

Brief summary: To evaluate the impact of using a computerized decision program on the adequacy of the perioperative antimicrobial prophylaxis

Detailed description: Adequacy rate of surgical antimicrobial prophylaxis, helped by a computerized decision support system, according to the internal guidelines considering the aspects: drug choice, dosing, timing, and re-dosing

Eligibility criteria: Inclusion Criteria:

* All elective \& emergency surgeries done by neurosurgery, orthopaedics, cardiovascular and digestive specialties made at University Hospitals of Geneva

Exclusion Criteria:

* Patients \< 40 kgs

Primary outcomes:
measure: Adequacy rate of surgical antimicrobial prophylaxis
timeFrame: baseline & 1 year
Secondary outcomes:
measure: Incidence of surgical site infections
timeFrame: baseline & 1 year
Other outcomes:
Locations:
city: Geneva
country: Switzerland
facility: University Hospitals of Geneva
Study officials:
affiliation: Clinical nurse specialist
name: Americo Agostinho, BSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04456335: Investigation of Supragingival Plaque Microbiome in Early Childhood Caries
Official title: Investigation of Supragingival Plaque Microbiome Using Next Generation Sequencing in Early Childhood Caries
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Early Childhood Caries
Keywords: Early childhood caries
Oral Microbiome
Next generation sequencing
Lead sponsor: Trakya University
Sponsor class: OTHER
Collaborators: name: Commission of Scientific Research Projects of Trakya University (TÜBAP)
First posted: 2020-07-02
Enrollment: 60
Sex: ALL
Minimum age (years): 36
Maximum age (years): 71
Standard ages: CHILD
Observational model: CASE_CONTROL
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A total of sixty children with early childhood caries(n=30) and caries free(n=30)

Brief summary: The purpose of this study was to characterize the supragingival plaque microbiome in children with early childhood caries and identify potential microorganisms associated with caries.

Detailed description: Sixty children with and without early childhood caries were recruited from Trakya University Faculty of Dentistry Department of Pediatric Dentistry. Oral examinations were performed by the same examiner according to diagnostic criteria of World Health Organisation (WHO) and The International Caries Detection and Assessment System (ICDAS) . Mothers' completed a structured questionnaire on the socio-demographic informations, child's feeding practices and oral hygiene habits. After the oral examination, supragingival plaque samples were collected from the posterior tooth surfaces. Supragingival plaque samples were examined with the Illumina MiSeq new generation sequencing method.

Eligibility criteria: Inclusion Criteria:

* 36-71 months old children
* No history of any medical problem
* No history of antibiotic in the three months prior to sampling
* Any sign of early childhood caries,
* Caries free children
* Mothers accepted to complete a structured questionnaire
* Children who cooperate for dental examination and sample collection

Exclusion Criteria:

* Children older than 71 months
* Medically compromised
* Children with antibiotic use history at last three months
* Children refused dental examination and plaque collection
* Mothers' refused to complete questionnare

Primary outcomes:
measure: V4-16S rRNA and ITS1 rRNA sequencing
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Edirne
country: Turkey
facility: Trakya Universitiy Faculty of Dentistry Department of Pediatric Dentistry
Study officials:
References:
Clinical trial NCT00740935: Impact of Systematic Infants Vaccination Against Rotavirus on Gastroenteritis Hospitalization: a Prospective Study in Brest District, France.
Official title: Impact of Systematic Infants Vaccination Against Rotavirus on Gastroenteritis Hospitalization: a Prospective Study in Brest District, France.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Rotavirus Gastroenteritis
Keywords: prevention
rotavirus vaccine
gastroenteritis
systematic vaccination
infants
aged 6 to 12 weeks
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
Collaborators: name: MCM Vaccines B.V.
First posted: 2008-08-25
Enrollment: 7204
Sex: ALL
Minimum age (years): 6
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Universal rotavirus vaccination program for infants born in Brest after February 2007, applied by the Centers for Maternal and Infant Health Protection, pediatricians and general practitioners.

Prospective surveillance of hospitalizations for gastroenteritis within the Pediatric Units of Brest University Hospital with systematic testing for Rotavirus.

Evaluation of the impact of the vaccination program on rotaviral gastroenteritis hospitalizations from 2007-2008 and 2008-2009, by comparison with epidemiological data from 2002-2007 in the absence of vaccination.

The principal judgement criterion is the number of pediatric hospitalizations for rotaviral GEA during the 2008-2009 epidemic in children A) under the age of 2 and B) residing in the suburbs of Brest.


Eligibility criteria: Inclusion Criteria:

* infants aged 6 to 12 weeks
* born in Brest District, France
* born between Feb 01, 2007 and Nov 19, 2009

Exclusion Criteria:

* contraindication to rotavirus vaccine

Primary outcomes:
measure: Hospitalization for gastroenteritis
timeFrame: 2 years
Secondary outcomes:
measure: Emergency department consultation for gastroenteritis
timeFrame: 2 years
Other outcomes:
Locations:
city: Brest
country: France
facility: Clinical Investigation Center
Study officials:
affiliation: University Hospital, Brest
name: Arnaud GAGNEUR, Doctor
role: STUDY_DIRECTOR
References:
citation: Roue JM, Nowak E, Le Gal G, Lemaitre T, Oger E, Poulhazan E, Giroux JD, Garenne A, Gagneur A. Impact of rotavirus vaccine on premature infants. Clin Vaccine Immunol. 2014 Oct;21(10):1404-9. doi: 10.1128/CVI.00265-14. Epub 2014 Jul 30.
citation: Gagneur A, Nowak E, Lemaitre T, Segura JF, Delaperriere N, Abalea L, Poulhazan E, Jossens A, Auzanneau L, Tran A, Payan C, Jay N, de Parscau L, Oger E; IVANHOE investigators. Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea: the IVANHOE study. Vaccine. 2011 May 12;29(21):3753-9. doi: 10.1016/j.vaccine.2011.03.035. Epub 2011 Apr 13.
Clinical trial NCT06835335: Opioid Prescribing in the Emergency Department for Sickle Cell Disease
Official title: Differential Opioid Prescribing in the Emergency Department for Patients with Sickle Cell Disease: a Vignette-based International Randomised Trial.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Discrimination, Racial
Pain Management
Emergency Medicine
Sickle Cell Disease
Lead sponsor: Centre Hospitalier Universitaire de Nīmes
Sponsor class: OTHER
First posted: 2025-02-19
Enrollment: 868
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Population will consist in emergency medicine resident and physician, speaking French or English, in European countries.

The population will be recruited with the use of professional networks and social medias

Brief summary: This study consists of a clinical vignette presented to emergency physicians asking them what they would prescribe to a patient with acute abdominal pain.


Eligibility criteria: Inclusion Criteria:

* Being a emergency physician

Exclusion Criteria:

* Working outside of Europe.

Primary outcomes:
measure: Morphine prescription
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: Analgesic prescription between groups
timeFrame: through study completion, an average of 1 year
measure: factors associated with differences in management between groups
timeFrame: through study completion, an average of 1 year
measure: Differences according to patient and practitioner gender
timeFrame: through study completion, an average of 1 year
Other outcomes:
Locations:
city: Nîmes
country: France
facility: CHU de Nîmes
state: Occitanie
city: Manchester
country: United Kingdom
facility: Manchester University NHS FT
Study officials:
References:
Clinical trial NCT03763435: The Effects of Pregnancy Classes and Contributing Factors to Postpartum Depression
Official title: The Effects of Pregnancy Classes on Postpartum Depression and Contributing Factors to Postpartum Depression
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Postpartum Depression
Sleep Disorder
Breast Feeding
Self Esteem
Keywords: postpartum depression
sleep disorder
genital self-image
breast-feeding
prevalence
Lead sponsor: Bartin State Hospital
Sponsor class: OTHER_GOV
First posted: 2018-12-04
Enrollment: 400
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: All women who gave birth in Bartin State Hospital (the only one hospital in the city) after October 2018. for three months.

Brief summary: It is recommended by the American College of Obstetricians and Gynecologists' Committee on Obstetric Practice that all obstetricians screen each women for postpartum depression and anxiety with a validated instrument. Although much effort is made, the contributing factors still lack in the literature due to its multi-factorial nature and complexity.

In addition, the effects of prenatal education classes remain understudied. Therefore, this study aims to demonstrate the prevalence, characteristics and contributing factors of the postpartum depression. In addition, the change in prevalence and characteristics of the postpartum depression among women who had prenatal classes and not will also be assessed.

Detailed description: Specific and validated instruments will be performed to women in their 8th week of postpartum period.

Those instruments are:

Edinburgh Postpartum Depression Scale (EPDS) Female genital self-image scale (FGSIS) Insomnia Severity Index (ISI) Breast-feeding efficacy scale short form (BSES-SF) Beck Depression Scale

Eligibility criteria: Inclusion Criteria:

* All women in the puerpera period (who gave consent)

Exclusion Criteria:

* None.

Primary outcomes:
measure: Postpartum Depression
timeFrame: Change between the 4th, 8th and 12th weeks of postpartum period
Secondary outcomes:
measure: Genital self-image
timeFrame: At 4th, 8th and 12th week of postpartum period
measure: sleep disorders
timeFrame: At 4th, 8th and 12th week of postpartum period
measure: breast-feeding
timeFrame: At 4th, 8th and 12th week of postpartum period
measure: socio-economic-demographical features
timeFrame: At 4th postpartum week
Other outcomes:
Locations:
city: Bartin
country: Turkey
facility: Bartin State Hospital
Study officials:
affiliation: Bartin State Hospital
name: Murat Yassa, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lanes A, Kuk JL, Tamim H. Prevalence and characteristics of postpartum depression symptomatology among Canadian women: a cross-sectional study. BMC Public Health. 2011 May 11;11:302. doi: 10.1186/1471-2458-11-302.