Clinical trial NCT02779972: Age Related Changes in Cardiac Physiology as a Predictor of Exercise Tolerance
Official title: Age Related Changes in Cardiac Physiology as a Predictor of Exercise Tolerance
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aging
Exercise Tolerance
Keywords: Cardiac Physiology
Physiology
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2016-05-23
Enrollment: 250
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients above 65 with preserved systolic function and stress echo on a treadmill between 1 Jan 2012 until 31 Dec 2015 in our facility

Brief summary: Aging is associated with numerous changes and adaptations in the cardiovascular system. Vascular and ventricular wall thickness increase, whereas arterial compliance, endothelial function, and ventricular contractility decline. The decline in cardiac function with advancing age is typically seen in parallel to reduced physical activity, and it has been proposed that lifelong exercise training might attenuate the effects of aging on the heart.

The cardiovascular system undergoes several age-related changes. For most healthy older individuals, the heart generally functions well under resting conditions. Structural and physiological changes tend to result in diminished exercise tolerance. However, increasingly it has been shown that even some of these changes are more a result of a sedentary lifestyle than an age-related phenomenon. Most elderly people tend to become less physically active. It is difficult to separate changes intrinsic to the aging process from those arising as a result of a sedentary lifestyle.

Detailed description: Previous large studies have concluded that resting LV diastolic and systolic function decline with age. The cardiovascular system undergoes several age-related changes. For most healthy older individuals, the heart generally functions well under resting conditions. Structural and physiological changes tend to result in diminished exercise tolerance. However, increasingly it has been shown that even some of these changes are more a result of a sedentary lifestyle than an age-related phenomenon. Most elderly people tend to become less physically active. It is difficult to separate changes intrinsic to the aging process from those arising as a result of a sedentary lifestyle. Studies of aging and physical activity usually compare older athletes with sedentary ones, in which physical activity was not found to attenuate the impact on the aging heart. Thus, the investigators set of to find the difference between hearts of elderly who are physically fit as measured with METS to those who are not. And try and understand the basis of this difference.

Eligibility criteria: Inclusion Criteria:

* All patients above 65 with preserved systolic function and stress echo on a treadmill between 1 Jan 2012 until 31 Dec 2015 in the facility.

Exclusion Criteria:

* Missing complete information used for data collection.

Primary outcomes:
measure: Cardiac output at maximal stress test
timeFrame: 45 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Tel Aviv
country: Israel
facility: The Tel Aviv Sourasky Medical Center
Study officials:
affiliation: 972-3-6947520
name: Ehud Chorin, MD
role: PRINCIPAL_INVESTIGATOR
References: