Clinical trial NCT01243424: CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes
Official title: A Multicentre, International, Randomised, Parallel Group, Double Blind Study to Evaluate Cardiovascular Safety of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Diabetes Mellitus, Type 2
Lead sponsor: Boehringer Ingelheim
Sponsor class: INDUSTRY
Collaborators: name: Eli Lilly and Company
First posted: 2010-11-18
Enrollment: 6103
Sex: ALL
Minimum age (years): 40
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to investigate the longterm impact on cardiovascular morbidity and mortality, relevant efficacy parameters (e.g., glycaemic parameters) and safety (e.g., weight and hypoglycaemia) of treatment with linagliptin in patients with type 2 diabetes at elevated cardiovascular risk receiving usual care, and compare outcome against glimepiride.


Eligibility criteria: Inclusion criteria:

1. Type 2 diabetes
2. Elevated glycosylated haemoglobin (HbA1c): 6.5 - 8.5%, inclusive, if treatment naïve or mono-/dual therapy with metformin and/or an alpha-glucosidase inhibitor; 6.5 - 7.5%, inclusive, if treatment with sulphonylurea/glinide in mono- or dual (with metformin OR an alpha-glucosidase inhibitor) therapy)
3. Pre-existing cardiovascular disease OR specified diabetes end-organ damage OR age =\> 70 years OR two or more specified cardiovascular risk factor
4. BMI =\< 45kg/m²
5. age between \>= 40 and =\< 85 years
6. signed and dated written International Conference of Harmonisation( ICF)
7. stable anti-diabetic background for at least 8 wks before study start

Exclusion criteria:

1. Type 1 diabetes
2. Treatment with other antidiabetic drugs (e.g. rosiglitazone, pioglitazone, Glucagon-like peptide 1 (GLP-1) analogue/agonists, Dipeptidyl-peptidase IV (DPP-IV) inhibitors or any insulin) prior to informed consent (previous short term use of insulin (up to two weeks) is allowed if taken at least 8 weeks prior informed consent)
3. treatment with any anti-obesity drug less than 3 months before ICF
4. uncontrolled hyperglycemia
5. previous or planned bariatric surgery or intervention
6. current or planned system corticoid treatment
7. change in thyroid hormones treatment
8. acute liver disease or impaired hepatic function
9. pre-planned coronary artery revascularization within 6 months of ICF
10. known hypersensitivity to any of the components
11. Inappropriateness of glimepiride treatment for renal safety issues according to local prescribing information
12. congestive heart failure class III or IV
13. acute or chronic metabolic acidosis
14. hereditary galactose intolerance
15. alcohol or drug abuse
16. participation in another trail with IMP given 2 months before Investigational Medicinal/Medical Product (IMP) start
17. pre-menopausal women who are nursing or pregnant or of child-bearing potential and not willing to use acceptable method of birth control
18. patients considered reliable by the investigator
19. acute coronary syndrome =\< 6 wks before ICF
20. stroke or Transient Ischemic Attack (TIA) =\< 3 months prior to ICF

Primary outcomes:
measure: The First 3-point Major Adverse Cardiovascular Events (3P-MACE)
timeFrame: From randomization until individual day of trial completion, up to 432 weeks
Secondary outcomes:
measure: The First 4-point (4P)- MACE
timeFrame: From randomization until individual day of trial completion, up to 432 weeks
measure: Percentage of Participants Taking Trial Medication at Trial End, Maintained Glycaemic Control (HbA1c ≤7.0%) Without Need for Rescue Medication, Without >2% Weight Gain, and Without Moderate/Severe Hypoglycaemic Episodes During Maintenance Phase
timeFrame: From Visit 6 (Week 16) to Final visit (Week 432) (Maintenance Phase)
measure: Percentage of Participants Who Were on Trial Medication at Trial End, Maintained Glycaemic Control (HbA1c ≤7.0%) Without Need for Rescue Medication, and Without >2% Weight Gain During Maintenance Phase
timeFrame: From Visit 6 (Week 16) to Final visit (Week 432) (Maintenance Phase)
measure: Percentage of Participants With the Occurrence of at Least One Event of 3P-MACE
timeFrame: From randomization until individual day of trial completion, up to 432 weeks
measure: Percentage of Participants With the Occurrence of at Least One Event of 4P -MACE
timeFrame: From randomization until individual day of trial completion, up to 432 weeks
measure: Percentage of Participants With Occurrence of Any of the Components of the Composite Endpoint of All Adjudication-confirmed Events
timeFrame: From start of the treatment until 7 days after the end of treatment, up to 433 weeks
measure: Time to First Occurrence of Any of the Components of the Composite Endpoint of All Adjudication-confirmed Events
timeFrame: From start of the treatment until 7 days after the end of treatment, up to 433 weeks
measure: Change From Baseline to Final Visit in Hemoglobin A1c (HbA1c)
timeFrame: Baseline and week 432
measure: Change From Baseline to Final Visit in Fasting Plasma Glucose (FPG)
timeFrame: Baseline and week 432
measure: Change From Baseline to Final Visit Fasting Total Cholesterol, Low-density Lipoprotein (LDL) Cholesterol and High-density Lipoprotein (HDL) Cholesterol
timeFrame: Baseline and week 432
measure: Change From Baseline to Final Visit in Triglycerides
timeFrame: Baseline and week 432
measure: Change From Baseline to Final Visit in Creatinine
timeFrame: Baseline and week 432
measure: Change From Baseline to Final Visit in Estimated Glomerular Filtration Rate (eGFR)
timeFrame: Baseline and week 432
measure: Change From Baseline to Final Visit in Urine Albumin Creatinine Ratio (UACR)
timeFrame: Baseline and week 432
measure: Percentage of Participants With Transition in Albuminuria Classes
timeFrame: Baseline and week 432
measure: Change From Baseline of Insulin Secretion Rate (ISR) at Fixed Glucose Concentration at 208 Weeks
timeFrame: Baseline and week 208
measure: Percentage of Participants With Occurrence of Accelerated Cognitive Decline at End of Follow-up
timeFrame: 433 weeks
measure: Continuous Glucose Monitoring (CGM) Sub-study: Change From Baseline in the Inter-quartile Range of Diurnal Glucose Variability (Milligrams/ Deciliter) to End of Study
timeFrame: Baseline
measure: CGM Sub-study : Change From Baseline in the Inter-quartile Range of Diurnal Glucose Variability (Millimoles/ Litre) to End of Study
timeFrame: Baseline
Other outcomes:
Locations:
city: Athens
country: United States
facility: North Alabama Research Center, LLC
state: Alabama
city: Birmingham
country: United States
facility: Alabama Internal Medicine, PC
state: Alabama
city: Birmingham
country: United States
facility: Cahaba Research, Inc.
state: Alabama
city: Mobile
country: United States
facility: Internal Medicine Center, LLC
state: Alabama
city: Mobile
country: United States
facility: Diagnostic and Medical Clinic
state: Alabama
city: Montgomery
country: United States
facility: Extended Arm Physicians, Inc.
state: Alabama
city: Tuscumbia
country: United States
facility: Office of Dr. Terence T. Hart MD
state: Alabama
city: Pell City
country: United States
facility: Advanced Clinical Research
state: Alaska
city: Mesa
country: United States
facility: Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
state: Arizona
city: Mesa
country: United States
facility: Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
state: Arizona
city: Tucson
country: United States
facility: Genova Clinical Research
state: Arizona
city: Tucson
country: United States
facility: Quality of Life Medical & Research Center
state: Arizona
city: Jonesboro
country: United States
facility: Northeast Arkansas Baptist Clinic
state: Arkansas
city: Little Rock
country: United States
facility: Medical Investigations, Inc
state: Arkansas
city: Little Rock
country: United States
facility: Aureus Research, Inc
state: Arkansas
city: Bermuda Dunes
country: United States
facility: Desert Oasis Healthcare
state: California
city: Fountain Valley
country: United States
facility: Edinger Medical Group and Research Center
state: California
city: Fullerton
country: United States
facility: Clinical Trials of St. Jude Heritage Med. Group
state: California
city: Long Beach
country: United States
facility: Long Beach Center for Clinical Research
state: California
city: Los Gatos
country: United States
facility: Office of Dr. Richard S. Cherlin
state: California
city: North Hollywood
country: United States
facility: Providence Clinical Research
state: California
city: Pomona
country: United States
facility: Chaparral Medical Group, Inc
state: California
city: Redondo Beach
country: United States
facility: ARI Clinical Trials, Inc
state: California
city: San Diego
country: United States
facility: San Diego Sports Medicine and Family Health Center
state: California
city: San Ramon
country: United States
facility: West Coast Research, LLC
state: California
city: Sylmar
country: United States
facility: University of California Los Angeles
state: California
city: Tarzana
country: United States
facility: Metabolic Institute of America
state: California
city: Tustin
country: United States
facility: Matrix Research Institute
state: California
city: Tustin
country: United States
facility: Orange County Research Center
state: California
city: Westlake Village
country: United States
facility: Westlake Medical Research
state: California
city: Colorado Springs
country: United States
facility: Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
state: Colorado
city: Colorado Springs
country: United States
facility: Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
state: Colorado
city: Boca Raton
country: United States
facility: East Coast Medical Associates
state: Florida
city: Davie
country: United States
facility: Todd Kazdan, DO Family Practice
state: Florida
city: Daytona Beach
country: United States
facility: Century Clinical Research, Inc
state: Florida
city: Doral
country: United States
facility: Doral Research Center
state: Florida
city: Edgewater
country: United States
facility: Riverside Clinical Research
state: Florida
city: Fort Lauderdale
country: United States
facility: Alan Graff, MD, PA
state: Florida
city: Fort Lauderdale
country: United States
facility: M & O Clinical Research, LLC
state: Florida
city: Hialeah
country: United States
facility: Eastern Research
state: Florida
city: Hialeah
country: United States
facility: Research in Miami Inc
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Impotence Treatment Center
state: Florida
city: Jacksonville
country: United States
facility: East Coast Institute for Research, LLC
state: Florida
city: Jacksonville
country: United States
facility: Care Partners Clinical Research LLC
state: Florida
city: Lauderdale Lakes
country: United States
facility: Precision Clinical Research, LLC
state: Florida
city: Miami
country: United States
facility: Veritas Research Corporation
state: Florida
city: Miami
country: United States
facility: APF Research, LLC
state: Florida
city: Miami
country: United States
facility: Swiss Medical Research
state: Florida
city: Miami
country: United States
facility: University of Miami
state: Florida
city: Miami
country: United States
facility: South Miami Clinical Research
state: Florida
city: Miami
country: United States
facility: Well Pharma Medical Research
state: Florida
city: Miami
country: United States
facility: Advanced Pharma CR, LLC
state: Florida
city: Miami
country: United States
facility: AppleMed Research Group, LLC
state: Florida
city: Miami
country: United States
facility: Kendall South Medical Center, Inc
state: Florida
city: New Port Richey
country: United States
facility: Suncoast Clinical Research, Inc.
state: Florida
city: New Port Richey
country: United States
facility: Advanced Research Institute, Inc
state: Florida
city: Opa-locka
country: United States
facility: Sunshine Research Center
state: Florida
city: Orlando
country: United States
facility: Diabetes and Endocrine Center of Orlando
state: Florida
city: Palm Harbor
country: United States
facility: Suncoast Clinical Research
state: Florida
city: Panama City
country: United States
facility: Misal Khan, MD FRCS, ED, PA
state: Florida
city: Pembroke Pines
country: United States
facility: Iconic Clinical Trials
state: Florida
city: Pensacola
country: United States
facility: Gulf Region Clinical Research Institute
state: Florida
city: Ponte Vedra Beach
country: United States
facility: St. John's Center for Clinical Research
state: Florida
city: West Palm Beach
country: United States
facility: Metabolic Research Institute
state: Florida
city: Atlanta
country: United States
facility: PMI Health Research Group
state: Georgia
city: Atlanta
country: United States
facility: Atlanta Diabetes Associates
state: Georgia
city: Dunwoody
country: United States
facility: Albert F. Johary MD, PC
state: Georgia
city: Snellville
country: United States
facility: Georgia Clinical Research, LLC
state: Georgia
city: Hayden Lake
country: United States
facility: Hayden Lake Family Physicians
state: Idaho
city: Meridian
country: United States
facility: Boise Kidney and Hypertension Institute
state: Idaho
city: Bolingbrook
country: United States
facility: Suburban Clinical Research
state: Illinois
city: Chicago
country: United States
facility: Cedar-Crosse Research Center
state: Illinois
city: Chicago
country: United States
facility: John H. Stroger Jr. Hospital of Cook Country
state: Illinois
city: Chicago
country: United States
facility: Apex Medical Research
state: Illinois
city: Evergreen Park
country: United States
facility: Pharmakon Inc
state: Illinois
city: Avon
country: United States
facility: American Health Network
state: Indiana
city: Brownsburg
country: United States
facility: Investigators Research Group, LLC
state: Indiana
city: Franklin
country: United States
facility: American Health Network of Indiana, LLC
state: Indiana
city: Indianapolis
country: United States
facility: Mapleton Medical Center
state: Indiana
city: Indianapolis
country: United States
facility: American Health Network, LLC
state: Indiana
city: Mishawaka
country: United States
facility: McKinley Research, LLC
state: Indiana
city: Muncie
country: United States
facility: American Health Network of Indiana, LLC
state: Indiana
city: Florence
country: United States
facility: MCM Clinical Research, LLC
state: Kentucky
city: Lexington
country: United States
facility: Kentucky Diabetes Endocrinology Center
state: Kentucky
city: Paducah
country: United States
facility: Four Rivers Clinical Research, Inc
state: Kentucky
city: Metairie
country: United States
facility: Crescent City Clinical Research
state: Louisiana
city: Bangor
country: United States
facility: Acadia Clinical Research, LLC
state: Maine
city: Baltimore
country: United States
facility: Office of Dr. Stephen R. Smith, MD
state: Maryland
city: Rockville
country: United States
facility: Endocrine and Metabolic Consultants
state: Maryland
city: North Attleboro
country: United States
facility: Tristan Medical Enterprises, PC dba Regeneris
state: Massachusetts
city: Canton
country: United States
facility: ClinSite, LLC
state: Michigan
city: Flint
country: United States
facility: Apex Medical Research, AMR Inc
state: Michigan
city: Kalamazoo
country: United States
facility: Westside Family Medical Center, PC
state: Michigan
city: Livonia
country: United States
facility: Tri City Medical Centers, PC
state: Michigan
city: Saint Clair Shores
country: United States
facility: KMED Research
state: Michigan
city: Sterling Heights
country: United States
facility: Tri-County Research, Inc
state: Michigan
city: Traverse City
country: United States
facility: Medical Research Associates
state: Michigan
city: Troy
country: United States
facility: Oakland Medical Research Center
state: Michigan
city: Minneapolis
country: United States
facility: Park Nicollet Institute
state: Minnesota
city: Biloxi
country: United States
facility: The Center for Clinical Trials, Inc.
state: Mississippi
city: Saint Louis
country: United States
facility: Mercy Health Research
state: Missouri
city: Omaha
country: United States
facility: Quality Clinical Research
state: Nebraska
city: Henderson
country: United States
facility: Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
state: Nevada
city: Las Vegas
country: United States
facility: Clinical Research of South Nevada
state: Nevada
city: Las Vegas
country: United States
facility: Palm Medical Research Center
state: Nevada
city: Atco
country: United States
facility: Atco Medical Associates, PC
state: New Jersey
city: Clifton
country: United States
facility: Summit Medical Group
state: New Jersey
city: Elizabeth
country: United States
facility: USMA Clinical Research
state: New Jersey
city: Elizabeth
country: United States
facility: Central Jersey Medical Research
state: New Jersey
city: Albany
country: United States
facility: Albany Medical Center / Albany Medical College
state: New York
city: Smithtown
country: United States
facility: Endocrine Associates of Long Island, PC
state: New York
city: West Seneca
country: United States
facility: Southgate Medical Group/ Southgate Medical Park
state: New York
city: Asheville
country: United States
facility: OnSite Clinical Solutions, LLC
state: North Carolina
city: Burlington
country: United States
facility: Kernodle Clinic West
state: North Carolina
city: Chapel Hill
country: United States
facility: The University of North Carolina at Chapel Hill
state: North Carolina
city: Charlotte
country: United States
facility: Internal Medicine Research
state: North Carolina
city: Charlotte
country: United States
facility: Gaffney Health Services
state: North Carolina
city: Durham
country: United States
facility: Durham Internal Medicine Associates
state: North Carolina
city: Elizabeth City
country: United States
facility: Sentara Family Medicine
state: North Carolina
city: Raleigh
country: United States
facility: PMG Research of Raleigh, LLC
state: North Carolina
city: Shelby
country: United States
facility: Carolina Research Center, Inc
state: North Carolina
city: Statesville
country: United States
facility: Piedmont Healthcare
state: North Carolina
city: Wilmington
country: United States
facility: PMG Research of Wilmington, LLC
state: North Carolina
city: Akron
country: United States
facility: Community Health Care of Manchester
state: Ohio
city: Austintown
country: United States
facility: Community Medical Associates, LLC
state: Ohio
city: Cadiz
country: United States
facility: Harrison Community Research Center
state: Ohio
city: Carlisle
country: United States
facility: Medical Frontiers, LLC
state: Ohio
city: Genoa
country: United States
facility: Genoa Medical Center
state: Ohio
city: Marion
country: United States
facility: Office of Dr. Craig S. Thompson, MD, LLC
state: Ohio
city: Marion
country: United States
facility: RAS Health Limited
state: Ohio
city: Maumee
country: United States
facility: Advanced Medical Research, LLC
state: Ohio
city: Zanesville
country: United States
facility: Pharmacotherapy Research Associates, Inc
state: Ohio
city: Oklahoma City
country: United States
facility: Infinity Research Group, LLC
state: Oklahoma
city: Tulsa
country: United States
facility: Castlerock Clinical Research Consultants, LLC
state: Oklahoma
city: Eugene
country: United States
facility: Oregon Medical Group
state: Oregon
city: Harleysville
country: United States
facility: Harleysville Medical Associates
state: Pennsylvania
city: Lansdale
country: United States
facility: Detweiler Family Medicine & Associates, PC
state: Pennsylvania
city: Philadelphia
country: United States
facility: Temple University School of Medicine
state: Pennsylvania
city: Warminster
country: United States
facility: Warminster Medical Associates, PC
state: Pennsylvania
city: Cranston
country: United States
facility: New England Center for Clinical Research, Inc
state: Rhode Island
city: Anderson
country: United States
facility: Hartwell Research Group, LLC
state: South Carolina
city: Greenville
country: United States
facility: Paris View Family Practice
state: South Carolina
city: Greer
country: United States
facility: Mountain View Clinical Research
state: South Carolina
city: Orangeburg
country: United States
facility: South Carolina Nephrology and Hypertension Center, Inc
state: South Carolina
city: Sumter
country: United States
facility: Carolina Diabetes & Kidney Center
state: South Carolina
city: Bristol
country: United States
facility: PMG Research of Bristol
state: Tennessee
city: Chattanooga
country: United States
facility: University Diabetes and Endocrine Consultants
state: Tennessee
city: Memphis
country: United States
facility: University of Tennessee
state: Tennessee
city: Tullahoma
country: United States
facility: Trinity Clinical Research, LLC
state: Tennessee
city: Arlington
country: United States
facility: KRK Medical Research
state: Texas
city: Austin
country: United States
facility: Austin Center for Clinical Research
state: Texas
city: Carrollton
country: United States
facility: Punzi Medical Center
state: Texas
city: Dallas
country: United States
facility: Dallas Diabetes and Endocrine Center
state: Texas
city: Dallas
country: United States
facility: Baylor Endocrine Center
state: Texas
city: Dallas
country: United States
facility: University of Texas Southwestern Medical Center
state: Texas
city: Houston
country: United States
facility: Jacon Medical Research Associates, LLC
state: Texas
city: Houston
country: United States
facility: JVC Family Medicine
state: Texas
city: Houston
country: United States
facility: Clinical Trial Network
state: Texas
city: Houston
country: United States
facility: Endocrine and Psychiastry Center
state: Texas
city: Houston
country: United States
facility: Pioneer Research Solutions, Inc.
state: Texas
city: Midland
country: United States
facility: Midland Clinical Research Center
state: Texas
city: New Braunfels
country: United States
facility: Hill Country Medical Associates
state: Texas
city: Odessa
country: United States
facility: Naidu Clinic
state: Texas
city: Pearland
country: United States
facility: The Methodist Hospital d/b/a HMRI CCAT at Pearland
state: Texas
city: Plano
country: United States
facility: Village Health Partners
state: Texas
city: San Antonio
country: United States
facility: Sun Research Institute
state: Texas
city: Schertz
country: United States
facility: Northeast Clinical Research of San Antonio, LLC
state: Texas
city: Sugar Land
country: United States
facility: Kenneth Otah and Associates
state: Texas
city: Midvale
country: United States
facility: PHS Clinical Trials
state: Utah
city: Salt Lake City
country: United States
facility: Highland Clinical Research
state: Utah
city: Burke
country: United States
facility: Burke Internal Medicine and Research
state: Virginia
city: Ettrick
country: United States
facility: Ettrick Health Center
state: Virginia
city: Manassas
country: United States
facility: Manassas Clinical Research Center
state: Virginia
city: Richmond
country: United States
facility: Clinical Research Partners, LLC
state: Virginia
city: Richmond
country: United States
facility: Richmond Family Practice
state: Virginia
city: Federal Way
country: United States
facility: Larry D Stonesifer, MD Inc., PS
state: Washington
city: Spokane
country: United States
facility: Premier Clinical Research
state: Washington
city: Bahía Blanca
country: Argentina
facility: Instituto de Investigaciones Clínicas de Bahía Blanca
city: Caba
country: Argentina
facility: CIPREC
city: Caba
country: Argentina
facility: CENUDIAB
city: Capital Federal
country: Argentina
facility: Instituto Médico Especializado
city: Capital Federal
country: Argentina
facility: Consultorios Asociados de Endocrinología e Invest Clínica
city: Cordoba
country: Argentina
facility: IPAC - Clínica Privada Caraffa SRL
city: Corrientes
country: Argentina
facility: Instituto Cardiovascular de Corrientes Juana Francisca Cabra
city: Córdoba
country: Argentina
facility: Ilaim-Ceom
city: La Plata
country: Argentina
facility: Hospital Italiano de La Plata
city: Mendoza
country: Argentina
facility: CIPADI
city: Rosario
country: Argentina
facility: Instituto de Investigaciones Clinicas de Rosario
city: Rosario
country: Argentina
facility: Instituto de Hematología y Medicina Clínica Dr. Rubén Davoli
city: Salta
country: Argentina
facility: Hospital San Bernardo
city: San Miguel de Tucumán
country: Argentina
facility: Investigaciones Clinicas Tucuman
city: Santa Fe
country: Argentina
facility: Instituto de Investigaciones Biomédicas
city: Santa Fe
country: Argentina
facility: Centro de Investigaciones Clínicas del Litoral
city: Herston
country: Australia
facility: Royal Brisbane & Women's Hospital-Endocrinology
state: Queensland
city: Meadowbrook
country: Australia
facility: Logan Hospital
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
state: South Australia
city: East Ringwood
country: Australia
facility: Eastern Clinical Research Unit
state: Victoria
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Blankenberge
country: Belgium
facility: Blankenberge - PRAC Vileyn, Geert
city: Bonheiden
country: Belgium
facility: Bonheiden - HOSP Imelda
city: De Pinte
country: Belgium
facility: De Pinte - PRAC Hollanders, Geert
city: Dessel
country: Belgium
facility: Retie - PRAC De Vos, Axel
city: Deurne
country: Belgium
facility: Deurne - PRAC Heyvaert, Frank
city: Deurne
country: Belgium
facility: Deurne - PRAC Verelst, Joost
city: Genk
country: Belgium
facility: Genk - PRAC Vernijns, J.
city: Gozée
country: Belgium
facility: Gozée - PRAC De Meulemeester, Marc
city: Hasselt
country: Belgium
facility: Hasselt - PRAC Vantroyen, Daniel
city: Herent
country: Belgium
facility: Herent - PRAC Denolf, Bart
city: Linkebeek
country: Belgium
facility: Linkebeek - PRAC Maury, Olivier
city: Moorsel
country: Belgium
facility: Moorsel - PRAC Van Mulders, N.
city: Natoye
country: Belgium
facility: Natoye - PRAC Balthazar, Y.
city: Tremelo
country: Belgium
facility: Tremelo - PRAC Vermeersch, Lode
city: Belém
country: Brazil
facility: Hospital Universitário João de Barros Barreto
city: Curitiba
country: Brazil
facility: Universidade Federal do Paraná
city: Goiânia
country: Brazil
facility: Hospital Geral de Goiânia Alberto Rassi
city: Higienópolis
country: Brazil
facility: Centro de Pesquisas Clínicas Ltda
city: Joaquim Távora
country: Brazil
facility: Centro de Estudos em Diabetes e Hipertensão
city: Porto Alegre
country: Brazil
facility: Irmandade Santa Casa de Misericordia de Porto Alegre
city: Porto Alegre
country: Brazil
facility: Centro de Pesquisas em Diabetes
city: Río de Janeiro
country: Brazil
facility: Instituto Estadual de Diabetes e Endocrinologia
city: Santa Cecília
country: Brazil
facility: Irmandade da Santa Casa de Misericórdia de São Paulo - IPEC - Instituto de Pesquisa Clínica
city: São José do Rio Preto
country: Brazil
facility: Instituto de Molestias Cardiovasculares - IMC
city: São Paulo
country: Brazil
facility: Hospital das Clinicas da FMUSP
city: Vila Clementino
country: Brazil
facility: Hospital do Rim e Hipertensão - UNIFESP
city: Pleven
country: Bulgaria
facility: Univ.Multiprofile Hospital "Dr. Georgy Stranski" EAD, Pleven
city: Sofia
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment
city: Sofia
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment "Zaritza Johanna"
city: Sofia
country: Bulgaria
facility: Military Medical Academy, Clin. Endocrinology & Metab. Dis.
city: Stara Zagora
country: Bulgaria
facility: MHAT Prof Stoyan Kirkovich AD
city: Quebec
country: Canada
facility: IUCPQ (Laval University)
state: Migration Data
city: St. John's
country: Canada
facility: First Line Medical Services Ltd.
state: Newfoundland and Labrador
city: St. John's
country: Canada
facility: Topsail Road Medical Clinic
state: Newfoundland and Labrador
city: Cambridge
country: Canada
facility: Cambridge Cardiac Care Inc.
state: Ontario
city: Hamilton
country: Canada
facility: Hamilton Medical Research Group
state: Ontario
city: Newmarket
country: Canada
facility: SKDS Research Incorporated
state: Ontario
city: Thornhill
country: Canada
facility: Wilderman Medical Clinic
state: Ontario
city: Toronto
country: Canada
facility: St. Michael's Hospital
state: Ontario
city: Toronto
country: Canada
facility: Albion Finch Medical Centre
state: Ontario
city: Montague
country: Canada
facility: Kings County Medical Centre
state: Prince Edward Island
city: Pointe Claire
country: Canada
facility: Dynamik Research
state: Quebec
city: Providencia
country: Chile
facility: Consulta Privada Maria Loreto Aguirre Coveña
city: Providencia
country: Chile
facility: Hospital de Servicios Médicos Godoy Ltda
city: Temuco
country: Chile
facility: Centro Medico Antulawen
city: Viña del Mar
country: Chile
facility: Hospital Naval Almirante Nef
city: Barranquilla
country: Colombia
facility: BioMelab
city: Barranquilla
country: Colombia
facility: Centro Cientifico Asistencial Jose Luis Accini
city: Barranquilla
country: Colombia
facility: Fundacion del Caribe de Investigacion Biomedica
city: Bogota
country: Colombia
facility: Endocare Research Institute
city: Bogotá
country: Colombia
facility: Dexa Diabetes Servicios Médicos Ltda
city: Bogotá
country: Colombia
facility: UNIENDO Unidad Integral de Endocrinologia
city: Cartagena
country: Colombia
facility: Centro cardiovascular Aristides
city: Cartagena
country: Colombia
facility: centro de Diagnostico Cardiologico para la Investigacion Bio
city: El Bosque
country: Colombia
facility: Fundacion Cardiovascular de Colombia
city: El Bosque
country: Colombia
facility: Fundación Oftalmologica de Santander
city: Tolima
country: Colombia
facility: Fundación Centro de Investigaciones Biomédicas Riescard
city: Jablonec nad Nisou
country: Czechia
facility: Internal & Diabetology Ambulance, Jablonec nad Nisou
city: Olomouc-Lazce
country: Czechia
facility: Diabetology & Internal Ambulance
city: Ostrava
country: Czechia
facility: Internal & Diabetology Ambulance Dr. Vrkoc, Ostrava
city: Plzen
country: Czechia
facility: Cardiology ambulance, Plzen
city: Praha 8
country: Czechia
facility: ResTrial s.r.o.
city: Praha
country: Czechia
facility: Diebetology internal Ambulance
city: Prostejov
country: Czechia
facility: Internal & Diabetology Ambulance, Prostejov
city: Strakonice
country: Czechia
facility: Hospital Strakonice, Internal Department
city: Helsinki
country: Finland
facility: Diabetesklinikka, Mehiläinen Töölö
city: Joensuu
country: Finland
facility: Lääkärikeskus Ite
city: Kerava
country: Finland
facility: Lääkärikeskus Aava Kerava
city: Kokkola
country: Finland
facility: Kokkolan Lääkärikeskus
city: Kuopio
country: Finland
facility: IteLasaretti
city: Oulu
country: Finland
facility: Terveystalo Oulu, Diapolis
city: Turku
country: Finland
facility: TYKS
city: Behren Les Forbach
country: France
facility: CAB Hell M, MG, Behren Les Forbach
city: Bordeaux
country: France
facility: HOP Haut Levèque, Diabéto, Pessac
city: Bourg des Comptes
country: France
facility: CAB Lemarie B, MG, Bourg des Cptes
city: Broglie
country: France
facility: CAB Cadinot Dr D, Broglie
city: Béziers
country: France
facility: CAB Breton Dr Nicolas
city: Cannes
country: France
facility: CAB Ferrier R, MG, Cannes
city: Carbonne
country: France
facility: CAB Jordan E, MG, Carbonne
city: Castets
country: France
facility: CAB Merlin P, MG Castets
city: Chartres
country: France
facility: CAB Fonteny R, MG, Chartres
city: Chartres
country: France
facility: CAB Fournier P, MG, Chartres
city: Cournonterral
country: France
facility: CAB Martocq G, MG, Cournonterral
city: Fort De France
country: France
facility: HOP, Fort de France, Fort de France
city: Hinx
country: France
facility: CAB Le Mouel S, MG, Hinx
city: La Reunion
country: France
facility: CAB Pholsena, MG, La Réunion
city: Labarthe sur Leze
country: France
facility: CAB Bismuth M
city: Louvigne De Bie
country: France
facility: CAB Zimmermann D
city: Maintenon
country: France
facility: CAB Mainetti P, MG, Maintenon
city: Orthez
country: France
facility: CAB Barucq F, MG, Orthez
city: Orthez
country: France
facility: CAB Mostephai M
city: Palau Del Vidre
country: France
facility: CAB Cassagnes JL, MG, Palau Del Vidre
city: Saint Genies Des Fontaines
country: France
facility: CAB Mercey Y, MG, St Genies des Fontaines
city: St Dié des Vosges Cedex
country: France
facility: Hop St Dié des Vosges, Diabéto, St Dié des Vosges
city: Thouars
country: France
facility: CAB Bonneau D, MG, Thouars
city: Tilly sur Seulles
country: France
facility: CAB Morel H, MG, Tilly sur Seulles
city: Batumi
country: Georgia
facility: Unimed Ajara LLC, Private Practice
city: Gori
country: Georgia
facility: Central Hospital LTD 'Gormedi', Gori
city: Kutaisi
country: Georgia
facility: L&J Clinic, Kutaisi
city: Tbilisi
country: Georgia
facility: EC Cardiology Clinic,Tbilisi
city: Tbilisi
country: Georgia
facility: National Center for Diabetes Research Ltd., Tbilisi
city: Tbilisi
country: Georgia
facility: National Institute of Endocrinology, Tbilisi
city: Tbilisi
country: Georgia
facility: Zhordania Institute of Human Reproduction, Tbilisi
city: Tbilisi
country: Georgia
facility: Medical Centre Medelite Ltd., Tbilisi
city: Tbilisi
country: Georgia
facility: Chemotherapy & Immunotherapy Clinic 'Medulla', Tbilisi
city: Zugdidi
country: Georgia
facility: JSC 'Curatio'
city: Aachen
country: Germany
facility: Universitätsklinikum Aachen, AöR
city: Aschaffenburg
country: Germany
facility: Studienzentrum Klausmann
city: Asslar
country: Germany
facility: Gemeinschaftspraxis, Asslar
city: Bad Nauheim
country: Germany
facility: Diabetes Schwerpunktpraxis
city: Berlin
country: Germany
facility: Praxis Dr. Naumburger, Berlin
city: Berlin
country: Germany
facility: emovis GmbH
city: Berlin
country: Germany
facility: Praxis Dr. Rieker, Berlin
city: Berlin
country: Germany
facility: IFG Institut für Gesundheitsförderung GmbH
city: Dormagen- Hackenbroich
country: Germany
facility: MVZ DaVita Dormagen GmbH
city: Dortmund
country: Germany
facility: Praxis Dr. Busch, Dortmund
city: Dresden
country: Germany
facility: GWT-TUD GmbH
city: Eisenach
country: Germany
facility: Praxis Dr. Schlecht, Eisenach
city: Elsterwerda
country: Germany
facility: ZKS Südbrandenburg GmbH
city: Essen
country: Germany
facility: Praxis Dr. Huptas, Essen
city: Flörsheim
country: Germany
facility: Praxis Dr. Schmidt, Flörsheim
city: Frankfurt
country: Germany
facility: Institut für Stoffwechselforschung, Frankfurt
city: Furth im Wald
country: Germany
facility: Praxis Dr. Groeneveld, Furth im Wald
city: Gebhardshain
country: Germany
facility: Praxis Dr. Kohlhas, Gebhardshain
city: Haag
country: Germany
facility: Praxis Dr. Samer, Haag
city: Hamburg
country: Germany
facility: Klinische Forschung Management & Services GmbH
city: Hamburg
country: Germany
facility: Diabetologische Schwerpunktpraxis
city: Hamburg
country: Germany
facility: Praxis Dr. Burkhardt, Hamburg
city: Hamburg
country: Germany
facility: Diabeteszentrum Alstertal, Hamburg
city: Kirchhatten
country: Germany
facility: Praxis Dr. Herrmann, Hatten
city: Köln
country: Germany
facility: Dünnwaldpraxis, Köln
city: Künzing
country: Germany
facility: Praxis Dr. Klein, Künzing
city: Leipzig
country: Germany
facility: Praxis Dr. Nischik, Leipzig
city: Lübeck
country: Germany
facility: Praxis Dr. Kropp, Lübeck
city: Mainz
country: Germany
facility: PFÜTZNER Science & Health Institute GmbH
city: Münster
country: Germany
facility: Diabetologische Schwerpunktpraxis
city: Neumünster
country: Germany
facility: Praxis Dr. Böckmann
city: Rehburg-Loccum
country: Germany
facility: Praxis Dr. Hilgenberg
city: Rodgau/Dudenhofen
country: Germany
facility: Praxis Dr. Naudts, Rodgau
city: Saarbrücken
country: Germany
facility: Praxis Dr. Hirschhäuser
city: Saint Ingbert / Oberwürzbach
country: Germany
facility: Praxis Dr. Segner, St. Ingberg
city: Schwabenheim
country: Germany
facility: Praxis Dr. Herrmann
city: Stadtbergen
country: Germany
facility: Praxis Dr. Dietlein
city: Wangen
country: Germany
facility: Praxis Dr. Sauter
city: Zwenkau
country: Germany
facility: Schwerpunktpraxis Diabetologie
city: Athens
country: Greece
facility: General Hospital of Athens Evangelismos
city: Haidari, Athens
country: Greece
facility: General University Hospital "Attikon"
city: Ioannina
country: Greece
facility: Univ. Gen. Hosp. of Ioannina
city: Melissia, Athens
country: Greece
facility: General Hospital "Amalia Fleming"
city: Nikaia
country: Greece
facility: General Hospital of Nikaia
city: Thessaloniki
country: Greece
facility: University General Hospital of Thessaloniki AHEPA
city: Thessaloniki
country: Greece
facility: General Hopsital of Thessaloniki "Ippokrateio"
city: Thessaloniki
country: Greece
facility: Kliniki Thermi
city: Hong Kong
country: Hong Kong
facility: Alice Ho Miu Ling Nethersole Hospital
city: Hong Kong
country: Hong Kong
facility: Prince of Wales Hospital
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
city: Ajka
country: Hungary
facility: Imre Magyar Hospital, Ajka
city: Baja
country: Hungary
facility: Lausmed Kft. Outpatient Unit of Internal Medicine
city: Budapest
country: Hungary
facility: Karolyi Sandor Hospital, Budapest
city: Gyula
country: Hungary
facility: Bekes County Pandy Kalman Hospital
city: Hódmezövásárhely
country: Hungary
facility: Erzsebet Hospital, Hodmezövasarhely
city: Mako
country: Hungary
facility: Dr. Samuel Diosszilagyi Hospital and Outpatient Clinic, Mako
city: Mosonmagyarovar
country: Hungary
facility: TaNa Med Kft.
city: Papa
country: Hungary
facility: Grof Esterhazy Hospital and Outpatient Clinic
city: Szekszard
country: Hungary
facility: Tolna County Balassa Janos Hospital
city: Ahmedabad
country: India
facility: Shree Krishna Hospital and Heart Care Centre, Ahmedabad
city: Aurangabad
country: India
facility: CIIGMA Institute of Medical Sciences Pvt Ltd
city: Bangalore, Karnataka
country: India
facility: MS Ramaiah Memorial Hospital,
city: Bangalore
country: India
facility: Diabetes care and research centre
city: Bangalore
country: India
facility: Manipal Hospital
city: Bangalore
country: India
facility: Bangalore Diabetes Centre (BDC)- Medisys Clinical Research
city: Belgaum
country: India
facility: Belgaum Diabetes Centre, Belgaum
city: Chennai
country: India
facility: Swamy Diabetes Centre
city: Chennai
country: India
facility: Apollo Hospitals
city: Chennai
country: India
facility: M V Hospital For Diabetes and Diabetes Research Centre
city: Chennai
country: India
facility: Dr. Mohans Diabetes Speciality Centre
city: Coimbatore
country: India
facility: Kovai Diabetes Speciality Centre & Hospital
city: Indore
country: India
facility: TOTALL Diabetes Hormone Institute
city: Jaipur
country: India
facility: Diabetes Thyroid and Endocrine Centre
city: Jaipur
country: India
facility: Diamed Clinical Research Services Pvt. Ltd.
city: Maharashtra
country: India
facility: Grant Medical Foundation, Ruby Hall Clinic
city: Mumbai, Maharastra
country: India
facility: K.G.N. Diabetes and Endocrine Centre
city: Mumbai
country: India
facility: Global Hospital- Superspeciality & Transplant Centre
city: Mumbai
country: India
facility: RHIDEM
city: Nagpur
country: India
facility: Sunil's Diabetes care and Research Centre
city: Pune
country: India
facility: Jahingir Clinical Development Centre
city: Pune
country: India
facility: Deshmukh Clinic
city: Thiruvananthapuram
country: India
facility: Diabetes Care Center
city: Vijayawada
country: India
facility: Yalamanchi Hospitals & Research Centres Pvt Ltd.
city: Co. Cork
country: Ireland
facility: The Red House Family Practice
city: Dublin
country: Ireland
facility: Connolly Hospital Blanchardstown
city: Gorey
country: Ireland
facility: The Palms GP Surgery
city: Wexford
country: Ireland
facility: Fethard-on-Sea Medical Practice
city: Ashkelon
country: Israel
facility: Barzilai Medical Center
city: Haifa
country: Israel
facility: Rambam Medical Center
city: Holon
country: Israel
facility: Edith Wolfson Medical Center, Diabetic Unit, Holon
city: Jerusalem
country: Israel
facility: Hadassah Medical Center, Ein-Karem
city: Nahariya
country: Israel
facility: Western Galilee Hospital
city: Tel Hashomer
country: Israel
facility: The Chaim Sheba Medical Center Tel Hashomer
city: Tel-Aviv
country: Israel
facility: Sourasky Medical Center
city: Cagliari
country: Italy
facility: Ospedale "SS. Trinità"
city: Catanzaro
country: Italy
facility: Policlinico Universitario Mater Domini, Universita di Catanzaro
city: Genova
country: Italy
facility: Policlinico San Martino
city: Guastalla (RE)
country: Italy
facility: Ospedale di Guastalla
city: Messina
country: Italy
facility: A.O.U.Policlinico G.Martino
city: Milano
country: Italy
facility: Fondazione Centro San Raffaele del Monte Tabor
city: Roma
country: Italy
facility: Ospedale S. Pertini
city: Roma
country: Italy
facility: Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
city: Sesto San Giovanni (MI)
country: Italy
facility: IRCCS Gruppo Multimedica
city: Aichi, Nagoya
country: Japan
facility: Daishinkai Medical Corporation Ookuma Hospital
city: Chiba, Matsudo
country: Japan
facility: Chibanishi General Hospital
city: Chiba, Matsudo
country: Japan
facility: New Tokyo Heart Clinic
city: Fukushima, Date
country: Japan
facility: Kashinoki I.M. Clinic, Fukushima, I.M.
city: Fukushima, Nihonmatsu
country: Japan
facility: Japan Community Health care Organization Nihonmatsu Hospital
city: Fukushima, Sukagawa
country: Japan
facility: Iwase General Hospital
city: Hyogo, Amagasaki
country: Japan
facility: Iryohojinshadan Sasaki Clinic
city: Hyogo, Takasago
country: Japan
facility: Takasagoseibu Hospital
city: Kanagawa, Yokohama
country: Japan
facility: Kanagawa Cardiovascular and Respiratory Center
city: Kumamoto, Kumamoto
country: Japan
facility: Jinnouchi Clinic Diabetes Care Center
city: Kumamoto, Yatsushiro
country: Japan
facility: Kumamoto Rosai Hospital
city: Miyazaki, Miyazaki
country: Japan
facility: Koga General Hospital
city: Saitama, Hanyu
country: Japan
facility: Saitama Medical Cooperative Association Hanyu General Hospital
city: Tokyo, Itabashi-ku
country: Japan
facility: Nihon University Itabashi Hospital
city: Ansan
country: Korea, Republic of
facility: Korea University Ansan Hospital
city: Busan
country: Korea, Republic of
facility: Inje University Busan Paik Hospital
city: Daegu
country: Korea, Republic of
facility: Keimyung University Dongsan Medical Center
city: Goyang
country: Korea, Republic of
facility: National Health Insurance Service Ilsan Hospital
city: Goyang
country: Korea, Republic of
facility: Dongguk University Ilsan Hospital
city: Goyang
country: Korea, Republic of
facility: Inje University Ilsan Paik Hospital
city: Jeonju
country: Korea, Republic of
facility: Chonbuk National University Hospital
city: Pusan
country: Korea, Republic of
facility: Pusan National Univ. Hosp
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Seoul
country: Korea, Republic of
facility: Kangdong Sacred Heart Hospital
city: Suwon
country: Korea, Republic of
facility: Ajou University Hospital
city: Wonju
country: Korea, Republic of
facility: Wonju Severance Christian Hosp
city: Yangsan
country: Korea, Republic of
facility: Pusan National University Yangsan Hospital
city: Johor Bahru, Johor
country: Malaysia
facility: Monash University
city: Kota Bharu
country: Malaysia
facility: Hospital University Sains Malaysia
city: Kuala Lumpur
country: Malaysia
facility: Hospital Kuala Lumpur
city: Kuala Lumpur
country: Malaysia
facility: University Malaya Medical Centre
city: Kuantan
country: Malaysia
facility: Hospital Tengku Ampuan Afzan
city: Melaka
country: Malaysia
facility: Hospital Melaka
city: Penang
country: Malaysia
facility: Penang Medical College
city: Taiping
country: Malaysia
facility: Hospital Taiping
city: Acapulco
country: Mexico
facility: Hospital General de Acapulco
city: Aguascalientes
country: Mexico
facility: Centro de Investigacion Cardiometabolica de Aguascalientes
city: Distrito Federal
country: Mexico
facility: Instituto Nacional de Cardiologia Ignacio Chavez
city: Guadalajara
country: Mexico
facility: Unidad de Investigacion Clinica Cardiometabolica de Occident
city: Monterrey
country: Mexico
facility: Hospital Universitario Dr Jose Eleuterio Gonzalez
city: 's-hertogenbosch
country: Netherlands
facility: Huisartspraktijk Emmers
city: Almere
country: Netherlands
facility: FlevoResearch
city: Amsterdam
country: Netherlands
facility: Academisch Medisch Centrum (AMC)
city: Beverwijk
country: Netherlands
facility: Rode Kruis Ziekenhuis Beverwijk
city: Breda
country: Netherlands
facility: Andromed Breda
city: Den Helder
country: Netherlands
facility: Noordwest Ziekenhuisgroep, location Den Helder
city: Eindhoven
country: Netherlands
facility: Andromed Eindhoven
city: Groningen
country: Netherlands
facility: Andromed Noord
city: Hoorn
country: Netherlands
facility: Vasculair Onderzoek Centrum
city: Maastricht
country: Netherlands
facility: Maastricht Universitair Medisch Centrum
city: Rotterdam
country: Netherlands
facility: Andromed Rotterdam
city: Rotterdam
country: Netherlands
facility: Rotterdam Research Institute
city: Rotterdam
country: Netherlands
facility: Ikazia Ziekenhuis
city: Sneek
country: Netherlands
facility: Antonius Ziekenhuis
city: Velp
country: Netherlands
facility: Andromed Oost
city: Zoetermeer
country: Netherlands
facility: Andromed Leiden-Zoetermeer
city: Christchurch
country: New Zealand
facility: Christchurch Hospital
city: Dunedin
country: New Zealand
facility: RMC Medical Research Ltd
city: Newtown Wellington NZ
country: New Zealand
facility: P3 Research, Wellington
city: Tauranga
country: New Zealand
facility: P3 Research, Promed House
city: Bodø
country: Norway
facility: Bodø Legesenter AS, avd. for med. studier
city: Elverum
country: Norway
facility: Medi 3 Innlandet AS, avd Elverum
city: Gjettum
country: Norway
facility: Vestre Viken HF, Bærum sykehus
city: Hamar
country: Norway
facility: M3 Helse AS
city: Jessheim
country: Norway
facility: Bylegene SA
city: Lierskogen
country: Norway
facility: Heiaklinikken
city: Oslo
country: Norway
facility: Rådhuset Spesialistsenter
city: Sandvika
country: Norway
facility: Sandvika Spesialistsenter
city: Sarpsborg
country: Norway
facility: Grålum Legesenter
city: Stavanger
country: Norway
facility: Forusakutten - Kolibri Medical, Avd. Stavanger
city: Ålesund
country: Norway
facility: Medi 3 AS
city: Arequipa
country: Peru
facility: Instituto Delgado de Investigacion Medica
city: Huacho
country: Peru
facility: Clinica San Pedro
city: Lima
country: Peru
facility: Hospital Nacional Dos de Mayo
city: Lima
country: Peru
facility: Clinica Internacional
city: Lima
country: Peru
facility: Centro de Investigaciones Médicas METABOLICARE SAC
city: Lima
country: Peru
facility: Clinica San Gabriel
city: Piura
country: Peru
facility: Centro De Especialidades Medicas Santa Maria S.A.C
city: San Miguel
country: Peru
facility: Clinica San Judas Tadeo
city: Iloilo
country: Philippines
facility: Center for Diabetes Care
city: Lipa City, Batangas
country: Philippines
facility: Mary Mediatrix Medical Center
city: Manila
country: Philippines
facility: Philippine General Hospital
city: Manila
country: Philippines
facility: University of Santo Tomas Hospital
city: Manila
country: Philippines
facility: Manila Doctors Hospital
city: Muntinlupa
country: Philippines
facility: Asian Hospital & Medical Center
city: Quezon City
country: Philippines
facility: St. Luke's Medical Center
city: Quezon City
country: Philippines
facility: Quirino Memorial Medical Center
city: San Juan
country: Philippines
facility: Cardinal Santos Medical Center
city: Surigao
country: Philippines
facility: Surigao Health Specialists
city: Amadora
country: Portugal
facility: Hospital Fernando Fonseca, EPE
city: Carnaxide
country: Portugal
facility: CHLO, EPE - Hospital de Santa Cruz
city: Coimbra
country: Portugal
facility: CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
city: Covilhã
country: Portugal
facility: Centro Hospitalar da Cova da Beira Hospital Pêro da Covilhã
city: Figueira da Foz
country: Portugal
facility: Hospital Distrital Figueira da Foz, EPE
city: Lisboa
country: Portugal
facility: Hospital da Luz
city: Porto
country: Portugal
facility: Centro Hospitalar São João,EPE
city: Santa Maria da Feira
country: Portugal
facility: Centro Hospitalar de Entre o Douro e Vouga, E.P.E. - Hospital de São Sebastião
city: Brasov
country: Romania
facility: SC Diabol SRL, Brasov
city: Bucharest
country: Romania
facility: Nicodiab SRL, Bucharest
city: Bucharest
country: Romania
facility: SC Medical Centre "Sanatatea Ta" SRL, Bucharest
city: Iasi
country: Romania
facility: Consultmed SRL, Iasi
city: Sibiu
country: Romania
facility: Emergency County Clinical Hospital, Sibiu
city: Tirgoviste
country: Romania
facility: Private Practice Dr. Remus Gagiu
city: Dzerzhinsky
country: Russian Federation
facility: LLC Clinic of new technologies of medicine
city: Izhevsk
country: Russian Federation
facility: City Clinical Hospital No. 6 of MoH of Udmurt Republic
city: Moscow
country: Russian Federation
facility: City Clinical Hospital No. 4, Moscow
city: Moscow
country: Russian Federation
facility: City Clinical Hospital No. 13, Moscow
city: Moscow
country: Russian Federation
facility: State Institution "Central Clinical Hospital of RAS", Moscow
city: Moscow
country: Russian Federation
facility: City Clinical Hospital No. 61, Moscow
city: Rostov-na-Donu
country: Russian Federation
facility: State Healthcare Institution, Regional hospital #2
city: Samara
country: Russian Federation
facility: Limited Liability Company "CENTER DIABET", Samara
city: Saratov
country: Russian Federation
facility: MMU City Outpatient Clinic no. 20, Saratov
city: Belgrade
country: Serbia
facility: Clinical Medical Center Zvezdara, Belgrade
city: Nis
country: Serbia
facility: Clinical Centre Nis
city: Pancevo
country: Serbia
facility: General Hospital Pancevo
city: Subotica
country: Serbia
facility: General Hospital Subotica, Internal Medicine
city: Zemun
country: Serbia
facility: Clinical Hospital Center Zemun
city: Banska Bystrica
country: Slovakia
facility: DIASTYLE s.r.o., Diabetology Outpatient Department
city: Dolny Kubin
country: Slovakia
facility: ENDIAMED s.r.o., Dolny Kubin
city: Levice
country: Slovakia
facility: CELL B s.r.o.
city: Levice
country: Slovakia
facility: DIA-KONTROL s.r.o.
city: Nove Zamky
country: Slovakia
facility: Funkystuff s.r.o., Nove Zamky
city: Povazska Bystrica
country: Slovakia
facility: Diabetologicka ambulancia MUDr. Lucia Gajdosikova s.r.o.
city: Zilina
country: Slovakia
facility: MEDIVASA s.r.o., Outpatient Clinic, Zilina
city: Cape Town
country: South Africa
facility: Dr. P. Patel
city: Cape Town
country: South Africa
facility: Dr. E. L. Janari
city: Durban
country: South Africa
facility: Dr. Vawda
city: Durban
country: South Africa
facility: Parklands Medical Centre
city: Krugersdorp
country: South Africa
facility: Dr. Jurgens
city: Lenasia
country: South Africa
facility: Dr. H. Makan
city: Lenasia
country: South Africa
facility: Dr. D. R. Lakha, Johannesburg
city: Port Elizabeth
country: South Africa
facility: Greenacres Hospital
city: Pretoria
country: South Africa
facility: Dr. M. Seeber
city: Somerset West
country: South Africa
facility: Vergelegen Medi-Clinic
city: Barcelona
country: Spain
facility: C.A.P. Sardenya
city: Barcelona
country: Spain
facility: CAP Les Corts
city: Barcelona
country: Spain
facility: CAP Casanova
city: Burjassot
country: Spain
facility: CAP Burjassot 1
city: Gijon
country: Spain
facility: C.S. Natahoyo
city: Girona
country: Spain
facility: Hospital Universitari de Girona Doctor Josep Trueta
city: L'Hospitalet de Llobregat
country: Spain
facility: CAP Florida
city: L'Hospitalet de Llobregat
country: Spain
facility: Hospital de Bellvitge
city: La Roca Del Vallés (Barcelona)
country: Spain
facility: CAP La Roca
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañón
city: Oviedo
country: Spain
facility: C.S. El Cristo
city: Oviedo
country: Spain
facility: C.S. Colloto
city: Oviedo
country: Spain
facility: C.S. Vallobin-La Florida
city: Pineda de Mar
country: Spain
facility: ABS Pineda de Mar
city: Santa Coloma De Gramanet
country: Spain
facility: Hospital de l'Esperit Sant
city: Tàrrega
country: Spain
facility: CAP Tàrrega
city: Valencia
country: Spain
facility: CS Ingeniero Joaquin Benlloch
city: Valencia
country: Spain
facility: Hospital Clínico de Valencia
city: Göteborg
country: Sweden
facility: CTC Sahlgrenska Universitetssjukhuset
city: Härnösand
country: Sweden
facility: Sjukhuset, Härnösand
city: Järfälla
country: Sweden
facility: Avonova Hälsa AB
city: Malmö
country: Sweden
facility: Skånes universitetssjukhus, Malmö
city: Rättvik
country: Sweden
facility: Dalecarlia Clinical Research Center
city: Rättvik
country: Sweden
facility: Södra Dalarnas vårdcentral, Hedemora
city: Skanör
country: Sweden
facility: Näsets Läkargrupp
city: Uddevalla
country: Sweden
facility: Vårdcentralen Silentzvägen
city: Vällingby
country: Sweden
facility: S3 Clinical Research Centers
city: Basel
country: Switzerland
facility: Allgemeine Medizin
city: Bellinzona
country: Switzerland
facility: FMH endocrinologia diabetologia
city: Bern
country: Switzerland
facility: Inselspital Bern
city: Lugano
country: Switzerland
facility: Dr. Pietro Gerber
city: Changhua
country: Taiwan
facility: Chang-Hua Christian Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Kaohsiung
country: Taiwan
facility: E-Da Hospital
city: New Taipei City
country: Taiwan
facility: Far Eastern Memorial Hospital
city: Taichung,
country: Taiwan
facility: Taichung Veterans General Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Tainan
country: Taiwan
facility: NCKUH
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Shih-Kong Wu Ho-Shu Memorial Hospital
city: Taipei
country: Taiwan
facility: Taipe Veterans General Hospital
city: Taipei
country: Taiwan
facility: Cheng Hsin General Hospital
city: Taipei
country: Taiwan
facility: Tri-Service General Hospital
city: Taipei
country: Taiwan
facility: Cardinal Tien Hospital
city: Taipei
country: Taiwan
facility: Taipei Medical University-Shuang Ho Hospital
city: Taipei
country: Taiwan
facility: Mackay Memorial Hospital
city: Monastir
country: Tunisia
facility: HOP Fattouma Bourguiba, Mint, Monastir
city: Sfax
country: Tunisia
facility: HOP Hédi Chaker, Endo, Sfax
city: Sousse
country: Tunisia
facility: HOP Farhat Hached, Mint, Sousse
city: Tunis
country: Tunisia
facility: HOP Habib Thameur, Mint, Tunis
city: Donetsk
country: Ukraine
facility: Donetsk Regional Clinical Hosp, Therapy Department
city: Ivano-Frankivsk
country: Ukraine
facility: Ivano-Frankivsk City Central Clinical Hospital
city: Kharkiv
country: Ukraine
facility: City Clinical Hospital No. 17, Kharkov
city: Kharkov
country: Ukraine
facility: City Clinical Hospital No. 27, Kharkiv
city: Kiev
country: Ukraine
facility: Clinic for Cardiology "Sertse i sudyny", Kiev
city: Kiev
country: Ukraine
facility: City Clinical Hospital No. 1, Kiev
city: Kyiv
country: Ukraine
facility: Poliklinika #2, Kyiv
city: Lvov
country: Ukraine
facility: City Hospital No. 5, Lvov
city: Odesa
country: Ukraine
facility: Odeska zaliznichna likarnya, Odessa
city: Vinnitsa
country: Ukraine
facility: Vinnitsia Regional Endocrinology Dispensary
city: Addlestone
country: United Kingdom
facility: Crouch Oak Family Practice
city: Ash Vale, Aldershot
country: United Kingdom
facility: Ash Vale Health Centre, Aldershot
city: Birmingham
country: United Kingdom
facility: Birmingham Heartlands Hospital
city: Chippenham
country: United Kingdom
facility: Hathaway Medical Centre
city: Durham
country: United Kingdom
facility: University Hospital of North Durham
city: Ely
country: United Kingdom
facility: St Mary's Surgery
city: Gloucester
country: United Kingdom
facility: Gloucestershire Royal Hospital
city: Great Yarmouth
country: United Kingdom
facility: James Paget University Hospital
city: Swansea
country: United Kingdom
facility: Morriston Hospital
city: Truro
country: United Kingdom
facility: Royal Cornwall Hospital
Study officials:
affiliation: Boehringer Ingelheim
name: Boehringer Ingelheim
role: STUDY_CHAIR
References:
citation: Verhagen C, Janssen J, Minderhoud CA, van den Berg E, Wanner C, Passera A, Johansen OE, Biessels GJ. Chronic kidney disease and cognitive decline in patients with type 2 diabetes at elevated cardiovascular risk. J Diabetes Complications. 2022 Oct;36(10):108303. doi: 10.1016/j.jdiacomp.2022.108303. Epub 2022 Aug 31.
citation: Verhagen C, Janssen J, Biessels GJ, Johansen OE, Exalto LG. Females with type 2 diabetes are at higher risk for accelerated cognitive decline than males: CAROLINA-COGNITION study. Nutr Metab Cardiovasc Dis. 2022 Feb;32(2):355-364. doi: 10.1016/j.numecd.2021.10.013. Epub 2021 Oct 27.
citation: Biessels GJ, Verhagen C, Janssen J, van den Berg E, Wallenstein G, Zinman B, Espeland MA, Johansen OE. Effects of linagliptin vs glimepiride on cognitive performance in type 2 diabetes: results of the randomised double-blind, active-controlled CAROLINA-COGNITION study. Diabetologia. 2021 Jun;64(6):1235-1245. doi: 10.1007/s00125-021-05393-8. Epub 2021 Feb 9.
citation: Rosenstock J, Kahn SE, Johansen OE, Zinman B, Espeland MA, Woerle HJ, Pfarr E, Keller A, Mattheus M, Baanstra D, Meinicke T, George JT, von Eynatten M, McGuire DK, Marx N; CAROLINA Investigators. Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes: The CAROLINA Randomized Clinical Trial. JAMA. 2019 Sep 24;322(12):1155-1166. doi: 10.1001/jama.2019.13772.
citation: Janssen J, van den Berg E, Zinman B, Espeland MA, Geijselaers SLC, Mattheus M, Johansen OE, Biessels GJ. HbA1c, Insulin Resistance, and beta-Cell Function in Relation to Cognitive Function in Type 2 Diabetes: The CAROLINA Cognition Substudy. Diabetes Care. 2019 Jan;42(1):e1-e3. doi: 10.2337/DC18-0914. No abstract available.
citation: Biessels GJ, Janssen J, van den Berg E, Zinman B, Espeland MA, Mattheus M, Johansen OE; CAROLINA(R) investigators. Rationale and design of the CAROLINA(R) - cognition substudy: a randomised controlled trial on cognitive outcomes of linagliptin versus glimepiride in patients with type 2 diabetes mellitus. BMC Neurol. 2018 Jan 15;18(1):7. doi: 10.1186/s12883-018-1014-7.
citation: Marx N, Rosenstock J, Kahn SE, Zinman B, Kastelein JJ, Lachin JM, Espeland MA, Bluhmki E, Mattheus M, Ryckaert B, Patel S, Johansen OE, Woerle HJ. Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA(R)). Diab Vasc Dis Res. 2015 May;12(3):164-74. doi: 10.1177/1479164115570301. Epub 2015 Mar 15.
citation: Chilton R. Linagliptin versus glimepiride add-on for the long-term treatment of Type 2 diabetes mellitus. Expert Rev Endocrinol Metab. 2013 Jul;8(4):345-349. doi: 10.1586/17446651.2013.811849.