Clinical trial NCT04738929: Comparing EVCO and EVOO
Official title: Comparing Acute Effects of Extra Virgin Coconut Oil and Extra Virgin Olive Oil Consumption on Appetite and Food Intake in Normal Weight and Obese Male Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Appetitive Behavior
Keywords: Extra virgin coconut oil; medium chain fatty acids; extra virgin olive oil; obesity; peptide YY; resting metabolic rate.
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
Collaborators: name: Hacettepe University
First posted: 2021-02-04
Enrollment: 20
Sex: MALE
Minimum age (years): 19
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The aim of this study is to compare acute effects of consuming extra virgin coconut oil (EVCO) as a source of medium chain fatty acids and extra virgin olive oil (EVOO) as a source of long chain fatty acids in normal weight and obese subjects.

Detailed description: Twenty male subjects (10 normal weight; 10 obese) consumed breakfast meals containing skimmed milk, fat-free white cheese, bread and EVCO (25 g) or EVOO (25 g). Visual analog scale evaluations, resting metabolic rate measurements and selected blood parameters analysis (glucose, triglyceride, insulin and plasma peptide YY) were performed before and after the test breakfast meals. In addition, energy intakes were evaluated by ad libitum lunch meal at 180 min.

Eligibility criteria: Inclusion Criteria:

* Metabolically healthy
* Aged 19-40 years
* Normal weight (BMI=18.5-24.9 kg/m²) and obese men (BMI=30-34.99 kg/m²)

Exclusion Criteria:

* smoking,
* alcohol consumption,
* weight gain/loss recently (\> %5, in three months),
* any genetic and metabolic diseases,
* any food allergy/intolerance,
* any medication,
* restrained eating habits.

Primary outcomes:
measure: Energy expenditure change
timeFrame: 0, 60, 120, 180 minutes
measure: Subjective appetite feelings change
timeFrame: 0, 30, 60, 120, 180 minutes
measure: glucose change
timeFrame: 0, 30, 60, 120, 180 minutes
measure: insulin change
timeFrame: 0, 30, 60, 120, 180 minutes
measure: peptide YY change
timeFrame: 0, 30, 60, 120, 180 minutes
measure: triglycerides change
timeFrame: 0, 30, 60, 120, 180 minutes
measure: Ad libitum energy intake
timeFrame: 180 minute
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Presidency of Republic of Turkey Health Center
Study officials:
affiliation: Ankara City Hospital Bilkent
name: Ziya Erokay Metin, Dr.
role: PRINCIPAL_INVESTIGATOR
affiliation: Hacettepe University
name: Pelin Bilgiç, Assoc. Prof.
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Mercan Merve Tengilimoğlu Metin, Assis. Prof.
role: STUDY_CHAIR
affiliation: Saglik Bilimleri Universitesi
name: Muzaffer Akkoca, Assoc. Prof.
role: STUDY_CHAIR
References:
citation: Metin ZE, Bilgic P, Tengilimoglu Metin MM, Akkoca M. Comparing acute effects of extra virgin coconut oil and extra virgin olive oil consumption on appetite and food intake in normal-weight and obese male subjects. PLoS One. 2022 Sep 16;17(9):e0274663. doi: 10.1371/journal.pone.0274663. eCollection 2022.