Clinical trial NCT06451224: Egyptian Arthroplasty Surgeons' Antibiotics Usage Awareness
Official title: Attitudes of Prophylactic Antibiotic Utilization During Primary Total Hip and Knee Arthroplasty Among Egyptian Joint Replacement Surgeons
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Infections Joint Prosthetic
Lead sponsor: South Valley University
Sponsor class: OTHER
Collaborators: name: Assiut University
First posted: 2024-06-11
Enrollment: 105
Sex: ALL
Minimum age (years): 25
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Active practicing Egyptian joint replacement surgeons

Brief summary: Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are procedures successfully applied to manage various end-stage chronic hip and knee diseases, such as osteoarthritis, rheumatoid arthritis, and femoral head avascular necrosis, as well as acute conditions, such as the neck of femur fractures, with excellent long-term functional outcomes. One of the devastating complications after such a procedure is periprosthetic joint infection (PJI). Various precautions are proposed to guard against such complications; one is the administration of perioperative antibiotics. However, injudicious or misuse of antibiotics could lead to the emergence of antimicrobial resistance, further complicating this matter. This is why various scientific and research organizations have proposed guidelines and a consensus for proper antibiotic use in perioperative THA and TKA surgery.

Antibiotic prophylaxis during primary THA and TKA can reduce the risk of PJI and surgical site infections. However, there is a lack of consensus on the optimal dosages and duration of prophylaxis, and guidelines vary among institutions. Alternatives such as extended oral antibiotic prophylaxis and different antibiotic regimens are being explored. International research is needed to establish best practices and determine the potential risks of antibiotic prophylaxis during primary THA and TKA. Unfortunately, the investigators are unaware of such guidelines proposed by any Egyptian health authority to guide and control the proper utilization of antibiotics during orthoapedic practice in general and joint replacement surgeries (THA and TKA) in particular.

Detailed description: This study will be an Online-based questionnaire investigating surgeons' perspectives on antibiotics utilization during primary total hip and knee arthroplasty surgeries and investigate their thoughts about the necessity for developing local guidelines.

Eligibility criteria: Inclusion criteria:

All Egyptian registered members of the Egyptian Pelvis and Hip Society, practicing Egyptian joint replacement surgeons (performing surgeries as a leading surgeon) who are willing to participate

Exclusion criteria:

* Members not listed in the E-mail directory of the society
* Surgeons refusing to participate
* Young surgeons who are not practicing independently

Primary outcomes:
measure: To determine the type of antibiotics administration during primary total hip and knee arthroplasty
timeFrame: 2 months
Secondary outcomes:
measure: To determine the dose of antibiotics administered during primary total hip and knee arthroplasty
timeFrame: 2 months
measure: To determine the timing of antibiotics administration during primary total hip and knee arthroplasty
timeFrame: 2 months
measure: To determine the length of antibiotics administration during primary total hip and knee arthroplasty
timeFrame: 2 months
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assuit Faculty of Medicine
Study officials:
affiliation: Assiut University
name: Ahmed Abd El-Aal, MD
role: STUDY_CHAIR
References: