louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03815422: Plantar Compartment Block in Hallux Valgus Ambulatory Surgery
Official title: Analgesia Quality and Quality of Deambulation of the Plantar Compartment Block After Hallux Valgus Ambulatory Surgery.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hallux Valgus Ambulatory Surgery
Keywords: Early ambulation
Plantar block
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2019-01-24
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with Plantar compartment block in Hallux Valgus ambulatory surgery

Brief summary: Hallux valgus surgery is known as a painful surgery. Qualitative pain management is the key to successful early recovery and rehabilitation.

Popliteal sciatic nerve block is widely used despite the risk of falling due to prolonged motor blockade.

Plantar block combined with distal peroneal block may be a better analgesic option in order to provide fast track rehabilitation.

The purpose of this study is to describe the analgesic effect of the plantar compartment block following hallux valgus surgery.


Eligibility criteria: Inclusion Criteria:

* Age between 18 and 75 years old
* patient covered by social health insurance
* have signed written informed consent
* scheduled for hallux valgus ambulatory surgery

Exclusion Criteria:

* protected patients or patients incapable of giving written informed consent
* pregnant or breastfeeding woman
* vulnerable adult
* inability to participate in pain scoring scales
* severe coagulopathy
* allergy or contraindications to study drugs
* preopérative gait disorders
* chronic kidney disease with glomerular filtration rate (GFR) ≤ 50 ml/min (estimated by the Cockroft and Gault formula)
* severe chronic liver disease
* chronic pain (treated by non steroidal anti inflammatory drugs, opioids, neuroleptic drugs, antidepressant or anticonvulsants)
* peripheral neuropathy
* intervention under general anesthesia

Primary outcomes:
measure: Analgesia quality of the plantar compartment block
timeFrame: 48 hours
Secondary outcomes:
measure: Quality of deambulation
timeFrame: Quality of deambulation during the first 2 postoperative days.
measure: postoperative analgesic
timeFrame: postoperative analgesic requirement, during the first 2 postoperative days.
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: Fabien SWISSER, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02337322: Immune Recovery in Advanced , ARV-naïve, HIV-1-infected Individuals Taking Dolutegravir or Ritonavir-boosted Darunavir
Official title: Immune Reconstitution in Severely Immunosuppressed Antiretroviral-naive HIV-1-Infected Patients (<100 CD4+ T Cells/μL) Taking Antiretroviral Regimens Based on Dolutegravir or Ritonavir-boosted Darunavir (the Advanz-4 Trial).
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Acquired Immune Deficiency Syndrome Virus
Keywords: Acquired Immune Deficiency Syndrome Virus
HIV
HIV-1
Antiretroviral treatment
HIV Advanced Disease
AIDS
Dolutegravir
Darunavir
Lead sponsor: Hospital Clinic of Barcelona
Sponsor class: OTHER
First posted: 2015-01-13
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: There are few randomized clinical trials in advanced HIV patients. This is a multicenter, randomized, open clinical trial, comparing 2 parallel groups, to compare the immunological reconstitution and the virological efficacy and safety of 2 different combinations of antiretroviral therapy given once a day (QD): abacavir plus lamivudine plus either dolutegravir, or darunavir-ritonavir during 96 weeks in advanced antiretroviral naïve HIV-1 infected patients with less than 100 CD4+ T-cells/mm3. Primary endpoint is the median increase in CD4+ T-cell count at 48 weeks after starting HAART.


Eligibility criteria: Inclusion Criteria:

1. HIV patients \> 18 years old who provide signed and dated informed consent.
2. Male and female.
3. Chronic HIV infection.
4. Antiretroviral naïve.
5. Confirmed CD4+ T cell count below 100 cells/mm3
6. HLA B5701 negative patients.

Exclusion Criteria:

1. Active opportunistic infections requiring parenteral treatment
2. Patients with cryptococcal meningitis treated with voriconazole
3. AIDS-defining cancers needing chemotherapy.
4. Female patients pregnant or breastfeeding.
5. Patients with documented history of allergy to sulfonamides.
6. Any contraindications to study drugs.

Primary outcomes:
measure: Median CD4 T cell count increase
timeFrame: 48 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Hospital Clinic of Barcelona
state: BCN
Study officials:
References:
Clinical trial NCT03537222: Quality of Life in Patients With Multiple Myeloma-validation Study
Official title: Validation of the Myeloma Patient Outcome Scale (MyPOS) Assessing the Quality of Life in Patients With Multiple Myeloma in the German Speaking Part of Switzerland
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Multiple Myeloma
Keywords: quality of life
psychometrics
Lead sponsor: Zurich University of Applied Sciences
Sponsor class: OTHER
Collaborators: name: Kantonsspital Münsterlingen
name: Kantonsspital Aarau
name: Klinik Hirslanden, Zurich
name: Celgene Corporation
name: King's College London
First posted: 2018-05-25
Enrollment: 58
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with multiple myeloma

Brief summary: In this study, the Myeloma Patient Outcome Scale (MyPOS) will be translated from English to German. This translated version will be quantitatively and qualitatively validated with patients with multiple myeloma.

Detailed description: Patients with multiple myeloma (N=10) will be interviewed in the qualitative phase about their comprehension of the translated MyPOS. The questionnaire will be revised according to the results of the interviews. This culturally adapted Swiss-German MyPOS will be assessed in the quantitative phase for its' psychometric properties with 200 patients with multiple myeloma.

Eligibility criteria: Inclusion Criteria:

* informed consent as documented by signature
* confirmed histological diagnosis of multiple myeloma,
* age ≥ 18 years,
* mental capacity to give written informed consent

Exclusion Criteria:

* inability to communicate in German
* participation in another clinical study
* more than one cancer diagnosis
* mental illness (i.e. psychiatric diagnosis)

Primary outcomes:
measure: Psychometric properties of the culturally-adapted Swiss-German Myeloma Patient Outcome Scale (MyPOS)
timeFrame: upon enrollment
Secondary outcomes:
Other outcomes:
Locations:
city: Münsterlingen
country: Switzerland
facility: Kantonsspital Münsterlingen
state: Thurgau
city: Aarau
country: Switzerland
facility: Kantonsspital Aarau
state: Zurich
city: Zurich
country: Switzerland
facility: Onkozentrum Hirslanden
Study officials:
affiliation: Zurich University of Applied Sciences
name: Julia Dratva, Prof.Dr.med
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01899222: Assessment of Prototype Hand-Held Fundus Camera
Official title: Assessment of Prototype Hand-Held Fundus Camera
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Normal Subject Population
Lead sponsor: University of Rochester
Sponsor class: OTHER
First posted: 2013-07-15
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Ophthalmology clinic

Brief summary: Assessment of handheld fundus images in comparison to conventional fundus camera images.

Detailed description: This study is comparing a small handheld camera with a standard fundus camera for image quality

Eligibility criteria: Inclusion criteria:

* Age \> 18
* The ability to give informed consent and be willing to spend up to two hours in the eye clinic during the duration of the study.
* The subjects may have a normal retina and optic nerve, or subjects may have abnormalities of the posterior pole of the retina or the optic nerve.

Exclusion criteria:

* Medical or ophthalmic instability that would create a contraindication for minimally invasive ophthalmic diagnostic testing will exclude participation as a subject.
* Ophthalmic pathology felt by the principal investigator that would make retinal imaging with standard photographs difficult or not possible.

Primary outcomes:
measure: Percentage of photographs that score a "3" or higher on the grading scale
timeFrame: 2-3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: University of Rochester
state: New York
Study officials:
References:
Clinical trial NCT04629222: Tracheobronchitis in Respiratory Involvement on the Lung SPECT/CT Images of Coronavirus Disease (COVID-19) Patients
Official title: Tracheobronchitis May Constitute the Main Sign of Respiratory Involvement on the Lung SPECT/CT Images of COVID-19 Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Infectious Disease of Lung
Keywords: Coronavirus Disease (COVID-19)
Lung ventilation
Perfusion scintigraphy
Tracheobronchitis
Shortness of breath
Cadmium-Zinc-Telluride (CZT)-SPECT
Computer Tomography (CT)
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2020-11-16
Enrollment: 10
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients experiencing shortness of breath during the course of a COVID-19

Brief summary: Tracheobronchitis signs may be observed on ventilation lung scintigraphy during coronavirus disease (COVID-19) infection. This case report study aimed to analyze the rates and associated factors of such tracheobronchitis in COVID-19 patients referred to ventilation/perfusion lung scintigraphy with shortness of breath, suspected of pulmonary embolism.

Detailed description: It was a retrospective study

Eligibility criteria: Inclusion Criteria:

* patient with Tracheobronchitis signs
* patient with lung scintigraphy exam

Exclusion Criteria:

* none

Primary outcomes:
measure: Tracheobronchitis signs may be observed on ventilation lung scintigraphy during COVID-19 infection.
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Vandœuvre-lès-Nancy
country: France
facility: CHRU of Nancy
Study officials:
References:
Clinical trial NCT00782522: Effect Study of an Eccentric Training Program and Stretching for Patients With Chronical Rotator Cuff Tendinopathy
Official title: Effect Study of an Eccentric Training Program and Stretching for Patients With Chronical Rotator Cuff Tendinopathy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronical Rotator Cuff Tendinopathy
Lead sponsor: University Ghent
Sponsor class: OTHER
Collaborators: name: Special Research Fund, Belgium
First posted: 2008-10-31
Enrollment: 69
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In the first part of the the study two new outcome measurements (force reproducibility and subacromial space) will be tested for reproducibility. Therefore 30 healthy people will be assessed.

In a second part of the study 60 patients will be randomly allocated to two groups. Group A (n=30) will perform a traditional training program and group B (n=30) will perform an eccentric training program.

Before the onset of the training programs, pain, function, maximal force, range of motion, subacromial space and force reproducibility will be assessed. Both training programs will be accomplished at home. The first six weeks there will be an appointment with the therapist once a week to explain, correct and when necessary, aggravate the exercises. The next six weeks these appointments will be diminished to once every two weeks.

After 6 and after 12 weeks of training the patients will be reassessed for all the parameters.


Eligibility criteria: Inclusion Criteria:

* global tendon thinning
* inhomogeneous echo partitioning
* calcifications at the insertion
* symptoms present for at least 3 months: painful resisted isometric abduction, painful palpation of the supraspinatus tendon, impingement tests positive

Exclusion Criteria:

* documented full thickness rotator cuff rupture
* other lesions than CRCT at the moment of the study
* echographic criteria for ruptures (focal thinning, fluid-filled gap,compressibility)

Primary outcomes:
measure: Maximum force, pain and function,range of motion, force reproduction, subacromial space
timeFrame: After 6 and after 12 weeks of training
Secondary outcomes:
Other outcomes:
Locations:
city: Ghent
country: Belgium
facility: University Hospital Ghent
Study officials:
affiliation: University Ghent
name: Ann Cools, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00536822: Antioxidant Status During Burn Rehabilitation
Official title: Prospective Assessment of Antioxidant Status of Pediatric Patients During Burn Rehabilitation
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Burns
Keywords: rehabilitation
pediatrics
Lead sponsor: Shriners Hospitals for Children
Sponsor class: OTHER
First posted: 2007-09-28
Enrollment: 0
Sex: ALL
Minimum age (years): 3
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: pediatric burn

Brief summary: It is believed that children with a prior history of significant burn injury continue to manifest low levels of antioxidants well into their convalescence.The purpose of this study is to examine malondialdehyde (an oxidative lipid marker) and vitamins E, C and beta carotene status in reconstructive burn patients.


Eligibility criteria: Inclusion Criteria:

* Greater than 3 but less than 19 years
* Reconstructive or followup outpatient care at least 1 year postburn
* Initial burn size \> 40%
* Written informed consent and HIPAA authorization

Exclusion Criteria:

* History of multivitamin or steroid use, liver disease, preburn malnutrition

Primary outcomes:
measure: serum antioxidant levels
timeFrame: > 2 years postburn
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Shriners Hospital for Children
name: Michele M Gottschlich
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01215422: Success of Pediatric Anesthesiologists in Learning to Use Videolaryngoscopes
Official title: Anesthesiologists Learning to Use Videolaryngoscopes in Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tracheal Intubation Morbidity
Keywords: Surgical procedures
Intubation
Anesthesiologist
Laryngoscope
Videolaryngoscope
Lead sponsor: University of Alberta
Sponsor class: OTHER
Collaborators: name: Verathon
name: KARL STORZ Endoscopy-America, Inc.
First posted: 2010-10-06
Enrollment: 646
Sex: ALL
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children being intubated for surgery

Brief summary: There are two new instruments on the market that anesthesiologists use when putting a breathing tube into the lungs of patients. The purpose of this study is to see how easily anesthesiologists can learn to use them in children.

Detailed description: Each anesthesiologist performed 20 timed baseline intubations. They were then randomized to perform 20 timed intubations with one of the two new videolaryngoscopes followed by 20 with the other new videolaryngoscope. The goal was to see how quickly they could become proficient.

Eligibility criteria: Inclusion Criteria for Children Population:

- Children requiring intubation for elective or non-elective surgery

Exclusion Criteria:

* Children with raised intracranial pressure
* Children with potential cervical spine injuries
* Children at risk for regurgitation because of a full stomach
* Children who were anticipated to have a difficult airway based on their physical appearance or previous experience were excluded.

Inclusion Criteria for Anesthesiologist Population:

\*Anesthesiologists who care for children at Stollery Children's Hospital

Exclusion Criteria for Anesthesiologist Population:

\*None

Primary outcomes:
measure: Success in Learning to Use a Videolaryngoscope(VLS)
timeFrame: Up to 5 minutes per intubation
Secondary outcomes:
measure: Cormack & Lehane Score
timeFrame: reported during intubation (up to 5 minutes)
measure: Time to Intubation, Analyzed by Order of Laryngoscopes Used
timeFrame: 4 years
measure: Time to Intubation, Stratified by Weight of Patients
timeFrame: 4 years
measure: Mean Years Since Completion of Anesthesiology Residency
timeFrame: Baseline (assessed as of 2008)
measure: Number of Intubation Attempts to Reach "Best Obtainable Time to Intubation"
timeFrame: less than 5 minutes per intubation
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: Stollery Children's Hospital
state: Alberta
Study officials:
affiliation: University of Alberta
name: Joan L Robinson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02936622: Paclitaxel-coated Peripheral Stents Used in the Treatment of Femoropopliteal Stenoses
Official title: Paclitaxel-coated Peripheral Stents Used in the Treatment of Femoropopliteal Stenoses
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Peripheral Arterial Disease (PAD)
Lead sponsor: Cook Group Incorporated
Sponsor class: INDUSTRY
First posted: 2016-10-18
Enrollment: 176
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This randomized multi-center study is intended to compare different coatings on stents for treatment of lesions of the above-the-knee femoropopliteal artery.


Eligibility criteria: Inclusion Criteria:

* One de novo or restenosed artherosclerotic lesion with ≥ 50% diameter stenosis
* Symptoms of peripheral arterial disease (Rutherford 2-4)

Exclusion Criteria:

* Pregnant, breastfeeding, or planning to become pregnant in the next 5 years
* Less than 18 years old
* Medical condition or disorder that would limit life expectancy to less than 12 months or that may cause noncompliance with the protocol or confound the data analysis
* Previous stent in the study vessel

Primary outcomes:
measure: The percent diameter stenosis within the study lesion evaluated by conventional angiography.
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Arnsberg
country: Germany
facility: Klinikum Hochsauerland
city: Bad Krozingen
country: Germany
facility: Universitäts Herzzentrum Freiburg - Bad Krozingen
city: Buchholz
country: Germany
facility: Krankenhaud Bucholz
city: Heidelberg
country: Germany
facility: St. Josefskrankenhaus Heidelberg
city: Jena
country: Germany
facility: Universitätsklinikum Jena
city: Karlsruhe
country: Germany
facility: SRH Klinikum Karlsbad- Langensteinbach GmbH
city: Leipzig
country: Germany
facility: Universitatsklinikum Leipzig AoR
city: Sonneberg
country: Germany
facility: MEDINOS Kliniken des Landkreises Sonneberg GmbH
city: Stuttgart
country: Germany
facility: Marienhospital Stuttgart
city: Würzburg
country: Germany
facility: Uniklinikum Würzburg
city: Auckland
country: New Zealand
facility: Auckland City Hospital, New Zealand
Study officials:
affiliation: Universitäts Herzzentrum Freiburg - Bad Krozingen
name: Thomas Zeller, Prof. Dr. med.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03300622: Assessment in Patients After Thoracic Surgery
Official title: Evaluation of Hospitalized Patients After Thoracic Pulmonary Resection Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Thoracic Surgery
Lead sponsor: Universidad de Granada
Sponsor class: OTHER
First posted: 2017-10-03
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Men and / or women of legal age who are admitted for lung resection, with the approval of the physician responsible, and who sign the informed consent

Brief summary: Lung cancer is the leading cause of death in men and the second in women with a 5 year survival in Europe of less than 15%. One of the methods most used for its treatment is pulmonary resection. The objective of this study is to analyze the clinical profile presented to patients after pulmonary resection.

Detailed description: One of the most widely used methods for the treatment of lung cancer is pulmonary resection. The morbidity and mortality of pulmonary resection surgery is conditioned by both the type of intervention and the patient's condition. Functional deterioration is a risk associated with hospitalization in the elderly, with a high prevalence (35-70%) and serious consequences, since in the majority it can lead to the appearance of complications not related to the reason for admission or the specific treatment. It is very important to evaluate the clinical profile of patients after pulmonary resection in order to stablish a more specific repercussion.

Eligibility criteria: Inclusion Criteria:

* Patient admitted for lung resection and who sign the informed consent

Exclusion Criteria:

* Patients who did not agree to sign informed consent and those who presented other types of problems to be able to adequately carry out the assessment, such as not handling the language.

Primary outcomes:
measure: Strength in upper and lower limbs
timeFrame: Baseline, up to 1 month
Secondary outcomes:
measure: Exercise capacity
timeFrame: Baseline, up to 1 month
Other outcomes:
measure: Mood
timeFrame: Baseline, up to 1 month
measure: Fatigue
timeFrame: Baseline, up to 1 month
measure: Changes in quality of sleep
timeFrame: Baseline, up to 1 month
measure: Comorbidities
timeFrame: Baseline
measure: Nutritional status
timeFrame: Baseline, up to 1 month
measure: Dyspnoea
timeFrame: PBaseline, up to 1 month
measure: Dependence
timeFrame: Baseline, up to 1 month
measure: Pain
timeFrame: Baseline, up to 1 month
measure: Cough
timeFrame: Baseline, up to 1 month
measure: Pain
timeFrame: Baseline, up to 1 month
Locations:
city: Granada
country: Spain
facility: Department of Physical Therapy
Study officials:
affiliation: Universidad de Granada
name: Marie Carmen Valenza, PT, PhD
role: PRINCIPAL_INVESTIGATOR
References: