Clinical trial NCT06241924: Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement
Official title: Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Parkinson Disease
Epilepsy
Keywords: Focal seizure
Parkinson disease
Hyperkinetic seizures
Hypokinetic disorders
Dyskinesia
Networks
Basal ganglia
Lead sponsor: University Hospital, Bordeaux
Sponsor class: OTHER
First posted: 2024-02-05
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range.

The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.

Detailed description: In order to define the link between the characteristics of the oscillations (frequency, amplitude, phase relation) within this cortico-subcortical network and movement (normal or pathological) in humans, a simple motor task of gripping/pulling a lever has been designed.

The local field potentials (LFPs) will be collected during the same motor task in :

i) patients with Parkinson's disease, using a high-resolution electroencephalogram (EEG) and the PERCEPT(TM) system (Medtronic) equipped with a "sensing" function for deep LFP recordings and in EEG-HR (for high resolution) for cortical recordings

ii) patients with focal drug-resistant epilepsy, during a pre-surgical assessment by stereo-electro-encephalography (SEEG). The SEEG allows the recording of both the cortex and the subcortical regions in a concomitant manner, and a direct correlation can be studied.

Eligibility criteria: Inclusion criteria :

* Male or Female
* Between 18 and 75 years of age
* With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device.
* Giving free, informed, written consent signed by the participant and the investigator Or
* With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
* With at least one electrode exploring the basal ganglia or the thalamus.
* Able to perform the simple motor task
* Affiliated or beneficiary of a social security scheme;
* Giving free, informed, written consent signed by the participant and the investigator

Exclusion criteria:

* Be incapable of giving consent personally
* Be subject to a legal protection measure or be placed under judicial protection;
* Being pregnant or breastfeeding
* Present a serious and/or decompensated somatic or psychiatric illness

Primary outcomes:
measure: difference in the cortico-subcortical electrophysiological coherence value
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: CHU de Bordeaux
Study officials:
affiliation: University Hospital, Bordeaux
name: Jérôme AUPY, Docteur
role: PRINCIPAL_INVESTIGATOR
References: