Clinical trial NCT00815269: Vasodilation Effect of Inhalational Anesthetics
Official title: Vasodilation Effect of Inhalational Anesthetics Including Halothane, Isoflurane, Sevoflurane, Desflurane and Enflurane
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: General Anesthesia
Keywords: Inhalant anesthetic
Vasodilation
General anesthesia
Ultrasonography
Lead sponsor: Nanjing Medical University
Sponsor class: OTHER
First posted: 2008-12-29
Enrollment: 300
Sex: ALL
Minimum age (years): 19
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Previous studies on animals suggest that inhalational anesthetics can reduce vascular tension in vitro resulting in vasodilation and decrease in blood pressure. This role for inhalational anesthetics has essential clinical implications such as the condition of sepsis or septic shock or other shock-associated states during which the blood vessel constricts strongly and leads to circulation dysfunction. The vasodilation property of these anesthetics including halothane, isoflurane, sevoflurane, desflurane and enflurane enables them to be better options than other general anesthetics in many clinical conditions needing the vasculature to be dilated. The investigators hypothesized that these inhalational anesthetics can evoke vasodilation measured with ultrasonography during general anesthesia in vivo as the in vitro studies displayed.


Eligibility criteria: Inclusion Criteria:

* Must be undergoing general anesthesia
* Age between 19-45 years

Exclusion Criteria:

* With hypertension
* Existing organic dysfunction
* Allergic to inhalant anesthetics
* Alcohol addictive or narcotic dependent patients
* A history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records

Primary outcomes:
measure: Ultrasonography of blood vessels including radial artery, brachial artery, femoral artery, popliteal artery
timeFrame: Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia
Secondary outcomes:
measure: Blood flow volume during anesthesia of the vasculature
timeFrame: Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia
measure: Blood pressure including systolic, diastolic and mean artery blood pressures
timeFrame: Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia
measure: The time interval of between the initiation of the inhalational anesthetics delivered to the beginning of decreasing of blood pressure
timeFrame: From the beginning of anesthesia (0 min) till the first time of blood pressure decreased, this measure would be varied according to different individuals
measure: The total dose of phenylephrine required to maintain baseline arterial blood pressure
timeFrame: From the beginning of anesthesia (0 min) to 20 min after anesthesia begun
measure: Regression and correlation analyses between different doses of the anesthetics and the extent of vasodilation
timeFrame: Forty eight hours after operation
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Nanjing Maternal and Child Health Care Hospital
state: Jiangsu
Study officials:
affiliation: Nanjing Medical University
name: XiaoFeng Shen, MD
role: STUDY_DIRECTOR
References: