Clinical trial NCT00684281: Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment
Official title: Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alzheimer's Disease
Lead sponsor: Assistance Publique Hopitaux De Marseille
Sponsor class: OTHER
First posted: 2008-05-26
Enrollment: 60
Sex: ALL
Minimum age (years): 50
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this project is to follow cohort of patients with aMCI in order to establish whether there are distinct subgroups in terms of evolution or aetiology, with distinct memory profiles and profiles of mesiotemporal atrophy and metabolic change

Detailed description: The syndrome of "amnestic Mild Cognitive Impairment" (aMCI) has been introduced for patients with intact activities of daily living, with a memory complaint and objective memory decline on neuropathological assessment, without significative change in other domains of cognition. Follow-up in these patients shows that the memory impairment may remain stable or improve, while it worsens or extends to other cognitive domains in others, indicating prodromal AD.

Eligibility criteria: Inclusion Criteria:

* Patients beforehand include in the PHRC 2001 study (These patients presented to the inclusion in the PHRC 2001 a qualified board of amnestic Mild Cognitive Impairment \[aMCI\] or light cognitive confusion of type amnestic)
* The patient must be affiliated to an insurance scheme disease to participate in this study

Exclusion Criteria:

* For the magnetic resonance imaging: usual contraindications for an examination by MRI: claustrophobia, metal foreign bodies, pacemakers, etc.
* Incapacitated to realize the neuropsychological evaluation because of medical intercurrentes disorders
* Appointment of a guardian

Primary outcomes:
measure: Pursue the longitudinal study of a troop of subjects presenting an amnestic MCI in 36 months after the initial diagnosis
timeFrame: 36 months
measure: Characterize the clinical evolution of these subjects: escalation with appearance of an insanity (of type Alzheimer's disease or of another type: degenerations fronto-temporal, insanity with body of Lewy), stabilization even improvement.
timeFrame: 36 months
measure: Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict an escalation
timeFrame: 36 months
measure: Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict a stabilization or an improvement.
timeFrame: 36 months
measure: Improve the state of the knowledge on the origin of the confusions mnésiques isolated at the persons of fifty and more years old.
timeFrame: 36 months
Secondary outcomes:
measure: Establish diagnostic criteria which allow to improve the sensibility and the specificity of the premature diagnosis of MY.
timeFrame: 36 months
measure: Determine if the ultra-premature diagnosis of MY at a stage where the hurts are still confined in the structures under - hippocampiques is possible.
timeFrame: 36 months
measure: Determine the specific character or not of the infringement of the memory of visual recognition in the novice Alzheimer's disease.
timeFrame: 36 months
measure: Determine the specific character or not the atrophy and the metabolic modifications of regions under - hippocampiques in the novice Alzheimer's disease.
timeFrame: 36 months
measure: Inform the existence of process of functional compensation in the population of aMCI, notably to those who show themselves stable or improve.
timeFrame: 36 months
Other outcomes:
Locations:
city: Marseille
country: France
facility: Hopital de la Timone- Service de neurologie et de neuropsychologie
Study officials:
affiliation: Assistance Publique des Hopitaux de Marseille
name: Matthieu CECCALDI, MD
role: PRINCIPAL_INVESTIGATOR
References: