louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00448773: REDucing Influenza Among University Students, University of California at Berkeley
Official title: Effectiveness of Selected Non-pharmaceutical Interventions in Reducing Influenza-like Illness Among University Students
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Influenza-like Illness
Influenza
Lead sponsor: Centers for Disease Control and Prevention
Sponsor class: FED
Collaborators: name: University of California, Berkeley
First posted: 2007-03-19
Enrollment: 3000
Sex: ALL
Minimum age (years): 17
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: We will be testing the hypothesis whether online education for UC Berkeley students on respiratory hygiene, cough etiquette, hand hygiene/awareness, as well as face mask use (while ill) will reduce the acquisition and transmission of influenza-like illness. The study will be conducted during the flu seasons 2006-7 and 2007-8.


Eligibility criteria: Inclusion Criteria:

* Registered students
* Attending UC Berkeley at least half-time during the study period

Exclusion Criteria:

* Enrolled but studying remotely or abroad for all or part of the study period
* Persons less than 17 years of age

Primary outcomes:
measure: Occurrence of influenza-like illness
Secondary outcomes:
Other outcomes:
Locations:
city: Berkeley
country: United States
facility: University of California, Berkeley
state: California
Study officials:
affiliation: University of California, Berkeley
name: Tomas J Aragon, MD, DrPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01044173: Plain Magnetic Resonance (MR) in the Assessment of Patients With Acute Abdomen
Official title: Assessment of Patients With Nontraumatic Acute Abdominal Pain With Plain MR of the Abdomen - a Comparison With CT
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Acute Abdomen
Keywords: acute abdomen
CT
MRI
fast imaging
Lead sponsor: Zealand University Hospital
Sponsor class: OTHER
First posted: 2010-01-07
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: At present, CT is the gold standard in the assessment of patients with acute abdomen. Yet, one CT of the abdomen exposes patients to a radiation dose equivalent to several years of background radiation. MR can be expected to yield the same information without ionizing radiation, but tends to be more time consuming. In this study, patients with nontraumatic acute abdominal pain referred to CT of the abdomen by the department of surgery will also have performed an additional MR scan covering the entire abdomen with few fast imaging sequences in approximately 15min. CT is the diagnostic test. The MR scan is only used for scientific purposes. It will be evaluated by a radiologist blinded for the results of the CT scan. Fourteen days after admission, a final diagnosis is established based on clinical, peroperative, pathological and lab. findings. The performance of CT and MR will then be compared. The investigators hypothesize that MR can provide a diagnostic accuracy comparable to CT.


Eligibility criteria: Inclusion Criteria:

* Signed informed consent form
* Age \> 18 years old
* Nontraumatic acute abdomen
* Weight \< 120kg
* Can keep apnoea for 15s
* Surgeon in charge considers patient fit for participation in study

Exclusion Criteria:

* Contraindications of MRI
* Suspicion of acute vascular disease
* Severe cardial or pulmonal insufficiency
* Pregnancy
* Untreated psychiatric illness

Primary outcomes:
measure: diagnostic accuracy of CT vs. MR
timeFrame: 14 days
Secondary outcomes:
Other outcomes:
Locations:
city: Koege
country: Denmark
facility: Koege Sygehus
Study officials:
affiliation: Zealand University Hospital
name: Thomas Jørgensen, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Zealand University Hospital
name: Jens Maier, MD
role: STUDY_DIRECTOR
References:
citation: Stoker J. Magnetic resonance imaging and the acute abdomen. Br J Surg. 2008 Oct;95(10):1193-4. doi: 10.1002/bjs.6378. No abstract available.
Clinical trial NCT02277873: Models for Evaluate the Proximity of the Moon on the Frequency of Births
Official title: Two Models for Evaluate the Effect of the Proximity of the Moon on the Frequency of Births. Study on Mexican Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Establish the Relationship Between Moon and Births
Keywords: moon
parturition
moon phases
Lead sponsor: Hospital General de Mexico
Sponsor class: OTHER_GOV
Collaborators: name: Instituto de Salud del Estado de Mexico
name: Hospital General de Mexico
name: Universidad Nacional Autonoma de Mexico
First posted: 2014-10-29
Enrollment: 25152
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pregnant women from urban and rural regions from north part of Mexico city county area

Brief summary: The purpose of this study is to establish the relationship between moon and births through two analytic models.

Detailed description: Retrospective, descriptive and observational study. Classical model performs comparisons of births among lunar periods, lineal, cubical and exponential estimation was performed in the SPSS software and the inflection point of the curve was estimated using the formula x=\[In (1/ebx)\]/ebx in the Geogebra model. The significance was establish by a p value of ≤ 0.05 (95% IC).

The second analysis was performed by the difference of media between all the stages of the moon cycle as in another trials. The difference was establish by the T-student test. The difference between groups was performed by the one way ANOVA test.

This study had the review and approval from the Ethics Committee of the institution and according with Mexican regulation, and in adherence to the Helsinki declaration and International Conference for Harmonisation

Eligibility criteria: Inclusion Criteria:

* Pregnant women from January 2009 until June 2013

Exclusion Criteria:

* Pregnant women from any other period of time

Primary outcomes:
measure: First model of analysis (Classic model)
timeFrame: up to 12 months
Secondary outcomes:
measure: Second model of analysis. Luminosity - Births
timeFrame: up to 34 weeks
Other outcomes:
Locations:
city: Cuautitlan
country: Mexico
facility: Hospital General de Cuautitlan
state: Estado de Mexico
Study officials:
affiliation: Hospital General de Mexico
name: Christian Ramos, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02375373: Effects of Adding Chickpeas to the American Diet (Long Term Study)
Official title: Effects of Adding Chickpeas to the American Diet on Fecal Microbiota Composition and Markers of Inflammation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Inflammation
Keywords: Gut Microbiota
Lead sponsor: University of Florida
Sponsor class: OTHER
Collaborators: name: American Pulse Association
First posted: 2015-03-02
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals directly associated with the University of Florida (faculty, staff, students) or through the University of Florida's Health Street program.

Brief summary: This prospective study will assess the effects of adding legumes, especially chick peas, to the diet of healthy adults on the commensal bacteria from feces of human subjects and resulting self-reported GI symptoms as well as markers of immune function.

Detailed description: Long-term observational study:

Subjects enrolled will participate in an observational setting for three months. During this time period, individuals will be encouraged, to maintain increased legume intake and explore new recipes that allow them to maintain a diverse menu of legume based foods. Fecal samples for microbiota analysis will be collected every month. Participants will record a weekly online questionnaire about legume intake and GI health as well as other health status updates. While participants will be encouraged to maintain regular intake of chickpeas throughout the long-term study, consumption of other legumes will be encouraged.

Eligibility criteria: Inclusion Criteria:

* Good Health
* No systemic antibiotics during the preceding two months
* No medication suppressing immune function
* Willingness to provide basic demographic as well as medical history data

Exclusion Criteria:

* Gastric Ulcers
* Inflammatory Bowel Disease (IBD) or Irritable Bowel Syndrome (IBS)
* Chronic constipation/diarrhea
* Body Mass Index (BMI) \> 30
* Dietary restrictions that prevent legume intake
* Currently on any medication that can affect GI transit time
* Consumption of \>3 servings/week of chickpeas or \>6 servings/week of legumes BEFORE study begins

Primary outcomes:
measure: Changes in Number of 16S RNA Sequences on Days 31, Day 62, and Day 93.
timeFrame: Change from Day 31, Day 62, and Day 93
Secondary outcomes:
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: Emerging Pathogens Institiute
state: Florida
Study officials:
affiliation: Associate Professor
name: Volker Mai, PhD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00365573: Doppler Ultrasonography Evaluation of Tibial Fracture Site Vascularity
Official title: Doppler Ultrasonography Evaluation of Tibial Fracture Site Vascularity
Study type: OBSERVATIONAL
Overall status: SUSPENDED
Conditions: Tibial Fracture
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2006-08-17
Enrollment: 30
Sex: ALL
Minimum age (years): 17
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patient witj tibial fracture.

Brief summary: The purpose of this study is to evaluate the blood supply to patients that are suffering from fracture in the tibia by UltraSound Doppler.


Eligibility criteria: Inclusion Criteria:

* Above 16 years old

Exclusion Criteria:

* Pregnancy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
Study officials:
affiliation: Hadassah Medical Organization
name: Ori Safran, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03700073: Correlation Physiological Cost Index
Official title: Correlation Between Physiological Cost Index and Health-related Quality of Life in Cerebral Palsy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebral Palsy
Keywords: physiological cost index
health-related quality of life
gait deviation index
gait analysis
cerebral palsy
Lead sponsor: Cardenal Herrera University
Sponsor class: OTHER
First posted: 2018-10-09
Enrollment: 26
Sex: ALL
Minimum age (years): 5
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objective: To compare the efficacy of a gait training program using robotic assistance combined with virtual reality versus robotic assistance alone on energy expenditure in children with cerebral palsy.

Participants: Children with cerebral palsy levels II, III, IV, and V according to the Gross Motor Function Classification System (GMFCS), from different paediatric physiotherapy centres and schools in Valencia, Spain.

Intervention: Gait training using an inexpensive robotic gait training system (CL1Walker) and participation in a virtual reality game, Treasure Hunt (abbreviated here as ACT, from the Spanish A la Caza del Tesoro) in the experimental group (GTVR) and gait training using the same robotic gait training system without using virtual reality in the control group (GT).

Measurements: Assessment using the Physiological Cost Index (PCI) one week prior to and after the intervention. The intraclass correlation (ICC) replicability and the minimum detectable change (MDC) of the PCI.

Detailed description: Design: Longitudinal, prospective, double blind study with two treatment groups and repeated measurements, controlled for the condition without virtual reality.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of cerebral palsy
* Must be able to follow the instructions and participate in the game

Exclusion Criteria:

* Orthopaedic surgery in lower limb
* Botulinum toxin in lower limb

Primary outcomes:
measure: Change from baseline Physiological cost index at 6 months
timeFrame: The test will be performed 6 month interval
Secondary outcomes:
Other outcomes:
Locations:
city: Valencia
country: Spain
facility: Clínica de Fisioterapia Maite Montañana
Study officials:
affiliation: Universidad CEU Cardenal Herrera, UCH CEU
name: Eva SEGURA-ORTÍ, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06025773: A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-212-A and AD-2121
Official title: A Randomized, Open-label, 2x2 Crossover-design Clinical Trial to Evaluate the Safety and Pharmacokinetic/Pharmacodynamic Characteristics After Oral Administration of AD-212-A or AD-2121 in Healthy Adult Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Gastro Esophageal Reflux
Lead sponsor: Addpharma Inc.
Sponsor class: INDUSTRY
First posted: 2023-09-06
Enrollment: 24
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Primary endpoint of this study is to evaluate the pharmacokinetic and pharmacodynamic characteristics of AD-212-A in healthy subjects.

Detailed description: The purpose of this study is to evaluate the pharmacokinetic and pharmacodynamic characteristics and safety profiles of AD-212-A compared with AD-2121 in healthy subjects.

Eligibility criteria: Inclusion Criteria:

* Body weight equal to or greater than 50kg and Body mass index (BMI) between 18.5 kg/m2 and 27.0 kg/m2 at the time of screening visit
* The Age equal to or greater than 19 in healthy volunteers at the time of screening visit
* Negative result from Serum Helicobacter pylori antibody at the time of screening visit

Exclusion Criteria:

* Patients with trouble performing Gastric pH monitoring

Primary outcomes:
measure: Area under the plasma concentration-time curve over a dosing interval at steady state (AUCτ,ss)
timeFrame: pre-dose to 24 hours of 1st administration versus pre-dose to 24 hours of repeated administration (7days)
measure: Percent Decrease from baseline of Integrated gastric acidity
timeFrame: 24 hours before 1st administration to 24 hours after repeated administration (7days)
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References:
Clinical trial NCT01092273: Bimatoprost Versus Travoprost at Cairo University
Official title: Bimatoprost Versus Travoprost in an Egyptian Population: A Hospital-Based Prospective Randomized Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Glaucoma
Ocular Hypertension
Keywords: Glaucoma and Ocular Hypertension
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2010-03-24
Sex: ALL
Minimum age (years): 20
Maximum age (years): 72
Standard ages: ADULT
OLDER_ADULT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hospital Based Study at Cairo University and Al Nour Eye Hospital

Brief summary: Bimatoprost has been shown to provide effective IOP lowering in patients of all races. Conversely, travoprost has been shown to be more effective in black patients than in Caucasians in some studies. However, Noecker et al 2004 compared bimatoprost with travoprost in African-Americans with glaucoma or OHT, and found that bimatoprost was more likely than travoprost to achieve target pressure at 3 months.

These racial differences in efficacy of these medications warrant further investigations. The investigators study aim to compare the IOP-lowering efficacies of bimatoprost and travoprost in an Egyptian population with primary open-angle glaucoma (OAG) or ocular hypertension (OHT).


Eligibility criteria: Inclusion Criteria:

* Glaucoma and Ocular Hypertension

Exclusion Criteria:

* Any ocular disease or medication that may raise the intraocular pressure.

Primary outcomes:
measure: Percentage of intraocular pressure lowering of bimatoprost versus travoprost.
Secondary outcomes:
measure: Rate of development of complications.
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
Study officials:
References:
Clinical trial NCT04621773: Live Birth Rate in Patients With Unexplained Recurrent Pregnancy Loss
Official title: Comparing the Live Birth Rate of Preimplantation Genetic Screening Versus Spontaneous Pregnancy in Patients With Unexplained Recurrent Pregnancy Loss
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Pregnancy Loss
Preimplantation Genetic Screening
Keywords: Unexplained Recurrent Pregnancy Loss
Preimplantation Genetic Screening
spontaneous pregnancy
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2020-11-09
Enrollment: 400
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who seek treatment in our Recurrent Pregnancy Loss clinic.

Brief summary: STUDY AIM: to study the pregnancy outcomes and offspring development of patient with Unexplained Recurrent Pregnancy Loss Treated by PGS and spontaneous pregnancy, and to compare the health economic indicators and patient satisfaction of the two modes of pregnancy, so as to better guide the clinical treatment.

Detailed description: 400 patients with two times or more unexplained pregnancy loss, who wants to be pregnant via preimplantation genetic screening procedure or spontaneous pregnancy are intended to be enrolled. They are going to divided into two groups: PGS(preimplantation genetic screening) group and SP(spontaneous pregnancy) group. The pregnancy outcomes and offspring development of those patients will be followed up by our investigators.

Eligibility criteria: Inclusion Criteria:

* patients with two times or more unexplained pregnancy loss(less than 24 weeks of gestational age, biochemical pregnancy excluded), who wants to be pregnant via preimplantation genetic screening procedure or spontaneous pregnancy.

Exclusion Criteria:

* anatomic abnormality of the reproductive system; endocrine metabolic disease; autoimmune related disease; chromosomal abnormalities; hydrosalpinx; cervical insufficiency.

Primary outcomes:
measure: Live birth rate
timeFrame: 2 years of following up
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Center of Reproductive Medicine, Peking University Third Hospital
state: Haidian
Study officials:
affiliation: Center of Reproductive Medicine, Peking University Third Hospital
name: Rong Li, M.D.
role: STUDY_CHAIR
References:
citation: Murugappan G, Shahine LK, Perfetto CO, Hickok LR, Lathi RB. Intent to treat analysis of in vitro fertilization and preimplantation genetic screening versus expectant management in patients with recurrent pregnancy loss. Hum Reprod. 2016 Aug;31(8):1668-74. doi: 10.1093/humrep/dew135. Epub 2016 Jun 7.
Clinical trial NCT06855173: Active External Rewarming from Accidental Hypothermia - a Dose-response Pilot Study
Official title: Active External Rewarming from Accidental Hypothermia - a Dose-response Pilot Study
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Accidental Hypothermia
Keywords: hypothermia
active external rewarming
Lead sponsor: Haukeland University Hospital
Sponsor class: OTHER
First posted: 2025-03-03
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this pilot study is to evaluate if there is a dose-response relationship between the use of active external rewarming devices and core temperature rewarming rate from simulated accidental hypothermia. Volunteer research participants will be cooled in a field laboratory, and they will recieve medications to inhibit shivering, enabeling a drop in core temperature. Subsequently, they will be treated with either one, two or four heating blankets, and analyses will be performed to investigate whether we are able to find a difference between the three groups.

Detailed description: The aim of this pilot study is to evaluate if there is a dose-response relationship between the use of active external rewarming devices and core temperature rewarming rate from simulated accidental hypothermia. Volunteer research participants will be cooled in a field laboratory, and they will recieve medications to inhibit shivering, enabeling a drop in core temperature. All participants will be monitored extensively using a trans-nasal esophageal temperature probe, ECG, SpO2, Blood pressure, skin temperature and with subjective scores. After the cooling phase, the participants will be treated with either one, two or four heating blankets assigned in a randomized order, and analyses will be performed to investigate whether we are able to find a difference between the three groups.

Eligibility criteria: Inclusion Criteria:

* Healthy

Exclusion Criteria:

* Normal BMI
* Smoking

Primary outcomes:
measure: Esophageal temperature rewarming rate
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Bergen
country: Norway
facility: Haukeland University Hospital
Study officials:
affiliation: Haukeland University Hospital
name: Øyvind Thomassen, MD, PhD
role: STUDY_DIRECTOR
References: