Clinical trial NCT03929081: Alternative Treatment to Reduce Chronicity in OCD: Research Into Brain Response and Adequacy of Treatment
Official title: Alternative Treatment to Reduce Chronicity in OCD: Research Into Brain Response and Adequacy of Treatment A Randomized Controlled Non-inferiority Trial Into the Effectiveness and Working Mechanisms of IBA in Comparison to CBT.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obsessive-Compulsive Disorder
Keywords: Obsessive-Compulsive Disorder
Inference Based Approach (IBA)
Cognitive Behavioral Therapy (CBT)
Personalized care
Neurocognitive working mechanisms of treatment
Non-inferiority
Prediction of treatment efficiency
Lead sponsor: GGZ Centraal
Sponsor class: OTHER
Collaborators: name: Amsterdam UMC, location VUmc
name: GGZ inGeest
name: PsyQ
name: Radboud University Medical Center
First posted: 2019-04-26
Enrollment: 246
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This is a multicenter, randomized controlled non-inferiority trial. 203 OCD patients will be recruited. During intake for treatment, patients willing to participate, will be invited for a baseline visit, after the Informed Consent process (IC). Then the patient will be randomized to 20 sessions IBA or 20 sessions CBT. Randomization ratio is 1:1, stratified by site. OCD symptom severity will be assessed by a blind assessor at baseline, after 20 sessions, and 6 and 12 months after posttest. Further, OCD symptom severity and insight in OCD symptoms will be assessed (self-report) weekly. To explore working mechanisms, 43 patients of each treatment arm will receive pre- and posttreatment brain imaging and neuropsychological assessment. After randomization, patients are screened for MRI eligibility, until the sufficient amount of participants is reached. A complementary IC will be signed. 43 healthy controls will receive a single brain imaging and neuropsychological testing session.
Primary purpose: TREATMENT

Brief summary: Rationale: Obsessive-Compulsive Disorder (OCD) is a disabling neuropsychiatric disorder that often has a chronic disease course. The standard psychotherapeutic treatment Cognitive Behavioural Therapy (CBT) is unable to redeem about half of all patients and is rejected by many because of its anxiety provoking methods. A promising alternative is the Interference Based Approach (IBA), which appears to be as effective as CBT, and more effective for patients with poor insight. The current study will investigate the proposed IBA non-inferiority to CBT. Furthermore, the neurobiological working mechanisms of both treatments will be investigated. Both treatment modalities are expected to alter activity and connectivity in different functional brain networks. In order to lead the way towards personalized care for OCD patients, clinical and neurobiological predictors of response to treatment will be studied. The eventual aim of this study is to prevent the demoralizing effect of undergoing an ineffective treatment by future prediction of whether an individual patient will respond better to IBA or CBT. This also contributes to solving the costs and waiting times for CBT.

Objective: To investigate non-inferiority of IBA compared to CBT and to unravel the neurobiological working mechanisms of both treatment modalities.

Study design: Multicentre randomized controlled trial.

Study population: 203 adults with a primary diagnosis of OCD and 43 healthy controls, matched on gender, age and educational level.

Intervention: The 203 adults with the primary diagnosis of OCD will be divided into the experimental- (IBA) and control intervention (CBT). Healthy controls will not receive an intervention.

Main study parameters/endpoints: Clinical measures (e.g. severity of OCD symptoms, disease insight), neurocognitive capabilities (performance on neuropsychological tests), neural correlates on brain structure (i.e. white matter integrity, grey matter volume) and brain function (i.e., activation and connectivity during resting state and symptom provocation) using 3 Tesla magnetic resonance imaging.

Detailed description: Sample size calculation: for the primary study objective, the 95-95 approach to determine the non-inferiority margin was used. Results of a meta-analysis on the effectiveness of CBT for OCD indicated that the mean (95 percent Confidence Interval (1.04) generates a non-inferiority margin of .42. Expressed in scores on the primary outcome measure Yale Brown Obsessive Compulsive Scale (YBOCS), this would be a loss of about 2 points on this scale with a range of 0-40, which is clinically almost negligible. Applying an alpha of 0.05, a beta of 80%, and a .42 non-inferiority margin, a sample size of 71 per arm is adequate. Since analyses have to be run on the per protocol (P)- and the intention-to-treat (ITT) sample, 203 participants have to be recruited (anticipating 30 percent drop-out). Moreover, this sample size allows testing the secondary hypothesis: IBA is more effective than CBT for patients with OCD with poor insight (approximately 25 percent of the population). Applying a two-sided alpha of 0.05 and a beta of 80 percent and effect size of Cohen's d =1, a sample of 34 participants is needed (in a previous study a between groups effect of 1.7 was found), anticipating 30 percent drop-out, 48 participants with poor insight at baseline are needed.

Previous studies into the influence of psychotherapy for OCD on brain structure and functioning have used sample sizes of 9-45. Based on their findings, analysing data for a minimum of 30 participants per condition is planned to explore the working mechanisms of the treatment modalities. Anticipating an upper limit of 30 percent drop-out rate, 2 x 43 respondents will be included, as well as 43 control subjects.

Adherence to treatment protocol: the therapists will be extensively trained in adherence to the protocol and the use of the premade forms for exercises and homework assignments. All treatment sessions will be audiotaped. Each therapist will receive supervision. During supervision, the supervisor will listen to parts of the audiotapes to give feedback and to make sure that the therapist does not drift from the protocol.

Furthermore, after the study is completed, there will be an adherence check. A trained blinded assessor will sample-wise listen to audiotapes of the session to score whether it was an IBA of CBT session.

Nature and extent of the burden and risks associated with participation, benefit and group relatedness: patients will be assessed during five time points, including two follow ups. Further, patients will fill in two questionnaires after each treatment session. Participants of the additional imaging part will be subjected to two extra sessions for MRI scanning and cognitive testing. Healthy controls will be measured once.

Safety Committee: the current study has been classified as low risk. No risk is expected of administering IBA, compared to receiving standard clinical care (CBT). IBA treatment will be conducted by well-trained clinicians. Some psychological discomfort may occur with respect to discussing emotional symptoms, these will be constraint to the minimum. No extra discomfort regarding to standard clinical care is expected. MRI scanning, after extensive screening for eligibility, is classified as a non-significant to low risk.

Statistical analyses: statistical analyses will be performed on the intention-to-treat (ITT) as well as the per-protocol sample (PP). Missing data will be replaced using the multiple imputation method. For all analyses, corrected p-values of \<0.05 will be regarded as statistically significant. Safety data (e.g. side effects) will be collected and summarized in the study results. A description of the analyses for the primary and secondary objectives is provided below.

Primary study parameter(s): the YBOCS, a validated questionnaire with 10 items and a maximum score of 40, will be used as the primary outcome parameter. To conclude non-inferiority, the upper margin of the 95 percent confidence interval, i.e. the maximum difference between groups within this 95 percent confidence interval, should not exceed the non-inferiority margin of 2 points on the YBOCS. To determine non-inferiority immediately following treatment and at follow-up, one-sided tests will be conducted at post-treatment, at six month follow-up and one year follow-up assessment. Linear mixed-effects models will be used, regressing the continuous outcome measures on intervention by time interaction terms, both in the ITT- and the PP-sample.

Secondary study parameter(s): mixed-effects models will be used to test the treatment effects between the two treatment conditions for the secondary outcome measures level of insight, using the Overvalued Ideas Scale (OVIS); severity of depressive symptoms, using the Beck Depression Inventory (BDI); severity of anxiety symptoms, using the Beck Anxiety Inventory (BAI); social functioning, using the Sheehan Disability Scale (SDS); quality of life (using the Euroquol); relationship satisfaction, using the Relationship Satisfaction Scale (RSS) and tolerability of treatment, using the Treatment Acceptability/Adherence Scale (TAAS). Exploratively a multiple regression analysis will be used to determine which factors predict treatment outcome.

A linear mixed model will be used to determine whether insight improves more or earlier in patients who underwent IBA compared to those who underwent CBT. A time-lag model (a linear mixed model) will be used to determine whether change in insight is related to symptom reduction.

Neuroimage (pre)processing: fMRI data will be analysed using Statistical parametric mapping (SPM) software or FMRIB Software Library (FSL). Standard group comparisons will be conducted to analyse structural and task-related (symptom provocation) (f)MRI. Full factorial analyses with the factors group (IBA vs CBT) and time (pre- vs posttreatment) will be conducted to determine the effect of treatment on task-related brain activity. Independent component analysis (ICA; FSL MELODIC) and dual regression analyses will be conducted to investigate changes in functional connectivity within networks (e.g. Salience Network, Default Mode Network, CEN). Brain regions with fluctuations concurrent over time in blood-oxygen level dependent (BOLD; proxy for brain activity) will automatically per person be assigned to a component. After filtering and a clean-up of the components (components that seem to result from movement or scanner artefacts), the mean components per group will be determined. By means of non-parametric permutation tests (FSL randomise), functional connectivity of the networks will be compared between the intervention groups and over time. To conduct whole-brain network analyses, the structural MRI will be parcellated into 225 separate regions of interest (ROIs) based on the Brainnetome atlas. These parcellations will be transformed to the resting-state fMRI and the time series will be extracted per ROI and correlated to each other to arrive at a whole-brain network connectivity matrix per subject. Using a similar network approach, the DTI images will allow for tractography in order to measure structural connectivity. The Brain connectivity toolbox (BCT) will be used to calculate topological indices of the networks (e.g. modularity, betweenness centrality, clustering coefficient and efficiency) from these network connectivity matrices. Network topological indices reduce the abundant amount of information resulting from the brain scan to only a few neurobiologically meaningful measures. Global efficiency, for instance, provides a measure of how efficiently information can travel through a network and betweenness centrality of the relative importance of a brain region for the information flow within a network. These topological network measures will be calculated per assessment and condition and subsequently compared by means of permutation tests.

Statistical Neuroimage analysing: to investigate whether treatment modality (IBA/CBT) predicts changes in resting state and task-based functional networks, a multivariate regression analysis will be conducted with treatment modality as independent variable and pre-to posttreatment changes in functional networks as dependent variables. To investigate the association with changes in YBOCS scores and neurocognitive performance, these variables will be entered in the first block. Possible confounders (e.g. medication use, age, disease duration) will be controlled for.

Machine learning techniques will be conducted to investigate whether multimodal pre-treatment brain characteristics (using T-1, DTI and rs- and task-based fMRI) have predictive value for treatment response in the CBT and IBA group separately. The neuroimaging characteristics will be entered into a supervised multivariate classification procedure using a linear support vector machine (SVM) algorithm.

The procedure consists of a training, validation and testing phase. During the training phase, a hyperplane will be estimated that maximally separates the remitters from the non-remitters based on all available data points (features) that show a difference between the groups. The SVM validation phase will consist of a leave-one-per-group-out cross-validation. Then the accuracy will be tested with which the determined hyperplane could classify other patients during the classification stage with independent data (20%) not used for training. This procedure will be iterated 10.000 times for each network. This results in an accuracy measure, per subject, based on the number of times the subject was included in the test sample and correctly classified. The accuracy will be tested on significance. If predictors of response to IBA differ from those to CBT, a post hoc analysis will be carried out with predictors for both IBA and CBT response within the entire OCD group.

Eligibility criteria: Inclusion Criteria:

Participants

* Referred to one of the participating sites for OCD treatment
* Age 18 or above
* Primary Diagnostic Statistical Manual (DSM)-5 diagnosis of OCD (established by the Structured Clinical Interview for DSM-5 (SCID)
* Moderate to severe OCD symptoms (expressed as a minimum score of 16 on the Yale Brown Obsessive Compulsive Scale (YBOCS)
* Not currently using psychotropic medication, or on a stable dose for at least 12 weeks prior to randomisation with no plans to change the dose during the course of the study (this will be monitored during the study)
* If CBT already has been received for OCD, treatment has ended at least 26 weeks before study participation.

Controls

- Age 18 or above

Exclusion Criteria:

Patients

* Suffering from a current psychotic disorder, organic mental disorder, substance use disorder or mental retardation
* No sufficient command of the Dutch language

Patients will be asked if they are willing to participate in the imaging study as well, including brain scans pre- and posttreatment. The selection will continue until 86 eligible participants are included for the MRI part of the study. Additional exclusion criteria apply for this sub study:

* Use of psychotropic medication other than Selective Serotonin Reuptake Inhibitor/Selective Norepinephrine Reuptake Inhibitor/clomipramine (e.g. antipsychotics). Occasional (not daily, a maximal equivalent of 10 mg. diazepam at a time) use of benzodiazepines/sleeping medication is allowed, if the participant is willing to tolerate to refrain from use for at least a week before the MRI scanning session, and able to tolerate this period of refrainment.
* Pregnancy
* Iron in the body
* Claustrophobia
* Any known neurological diseases (including epilepsy) or brain surgery
* Head trauma that resulted in unconsciousness for at least 1 hour
* Age 65 or above
* Controls
* Age 65 or above
* Current DSM-5 diagnosis (established by the SCID)
* Personal history of DSM-5 diagnosis, except for depressive or anxiety disorder longer than 12 months ago
* Personal history or current use of psychotropic medication (excluding sporadic use of sedatives/benzodiazepines, not having been used the week prior to participation
* First-degree relative (parent/sibling/child) with OCD or tic-disorder
* Insufficient command of the Dutch language
* Pregnancy
* Iron in the body
* Claustrophobia
* Any known neurological diseases (including epilepsy), or past brain surgery
* Head trauma that resulted in unconsciousness for at least 1 hour

Primary outcomes:
measure: Change from baseline score on the Yale Brown Obsessive Compulsive Scale (YBOCS) after 20 sessions IBA or CBT, and after 6 months and 1 year post treatment
timeFrame: at baseline; post intervention at week 20; at follow up 6 months post week 20; at follow up 12 months post week 20
Secondary outcomes:
measure: Change from baseline brain morphology measured by Magnetic Resonance Imaging (MRI) after 20 sessions IBA or CBT
timeFrame: at baseline; post intervention at week 20
measure: Change from baseline structural connectivity measured by Diffusion Tensor Imaging (DTI) after 20 sessions IBA or CBT
timeFrame: at baseline; post intervention at week 20
measure: Change from baseline activity and functional connectivity measured by resting state functional Magnetic Resonance Imaging (rs-fMRI) after 20 sessions IBA or CBT
timeFrame: at baseline; post intervention at week 20
measure: Change from baseline activity and functional connectivity measured by functional Magnetic Resonance Imaging (fMRI) during OCD symptom provocation after 20 sessions IBA or CBT
timeFrame: at baseline; post intervention at week 20
measure: Change from baseline score on the Overvalued Ideas Scale (OVIS) after 20 sessions IBA or CBT, and after 6 months and 1 year post treatment
timeFrame: at baseline; post intervention at week 20; at follow up 6 months post week 20; at follow up 12 months post week 20
measure: Change form baseline on the Yale-Brown Obsessive Compulsive Scale self-report questionnaire (YBOCS-SR) after each therapy session IBA or CBT
timeFrame: at baseline; at every therapy session at week 0-20
measure: Change from baseline on the Overvalued Ideas Scale - Self Report (OVIS-SR)
timeFrame: at baseline; at every therapy session at week 0-20
measure: Treatment Acceptability/Adherence Scale (TAAS)
timeFrame: at baseline after randomization
measure: Treatment Acceptability/Adherence Scale (TAAS)
timeFrame: mid intervention at week 10
measure: Treatment Acceptability/Adherence Scale (TAAS)
timeFrame: post intervention at week 20
measure: Change from baseline performance on Tower of London Task (ToL) after 20 sessions of IBA or CBT
timeFrame: at baseline; post intervention at week 20
measure: Change from baseline performance on Visual Spatial N-back Task after 20 sessions of IBA or CBT
timeFrame: at baseline; post intervention at week 20
measure: Change from baseline performance on Stop Signal Task (SST) after 20 sessions of IBA or CBT
timeFrame: at baseline; post intervention at week 20
measure: Change from baseline score on the Beck Depression Inventory (BDI), after 10 sessions IBA or CBT, at post treatment after 20 sessions IBA or CBT and after 6 months and 1 year post treatment
timeFrame: at baseline;mid-treatment at week 10; post intervention at week 20; at follow up 6 months post week 20; at follow up 12 months post week 20
measure: Change from baseline score on the Beck Anxiety Inventory (BDI), after 10 sessions IBA or CBT, at post treatment after 20 sessions IBA or CBT and after 6 months and 1 year post treatment
timeFrame: at baseline;mid-treatment at week 10; post intervention at week 20;at follow up 6 months post week 20; at follow up 12 months post week 20
measure: Change from baseline score on Euroquol, after 10 sessions IBA or CBT, at post treatment after 20 sessions IBA or CBT and after 6 months and 1 year post treatment
timeFrame: at baseline;mid-treatment at week 10; post intervention at week 20; at follow up 6 months post week 20; at follow up 12 months post week 20
measure: Change from baseline score on Sheehan disability Scale (SDS), after 10 sessions IBA or CBT, at post treatment after 20 sessions IBA or CBT and after 6 months and 1 year post treatment
timeFrame: at baseline;mid-treatment at week 10; post intervention at week 20; at follow up 6 months post week 20; at follow up 12 months post week 20
measure: Change from baseline score on Relationship Satisfaction Scale (RSS), after 10 sessions IBA or CBT, at post treatment after 20 sessions IBA or CBT and after 6 months and 1 year post treatment
timeFrame: at baseline;mid-treatment at week 10; post intervention at week 20; at follow up 6 months post week 20; at follow up 12 months post week 20
Other outcomes:
measure: Change on performance on the Confidence Accuracy Task after 20 sessions of IBA or CBT
timeFrame: at baseline; post intervention at week 20
measure: Change of valence rating of symptom provocation stimuli after 20 sessions of IBA or CBT
timeFrame: at baseline; post intervention at week 20
Locations:
city: Assen
country: Netherlands
facility: GGz Drenthe
state: Drenthe
city: Ermelo
country: Netherlands
facility: GGz Centraal
state: Gelderland
city: Nijmegen
country: Netherlands
facility: Pro Persona
state: Gelderland
city: Maastricht
country: Netherlands
facility: Mondriaan
state: Limburg
city: Amsterdam
country: Netherlands
facility: GGz InGeest
state: Noord-Holland
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, VUmc
state: Noord-Holland
city: Amsterdam
country: Netherlands
facility: PsyQ Amsterdam
state: Noord-Holland
Study officials:
affiliation: GGZ Centraal
name: Henny Visser, PhD
role: PRINCIPAL_INVESTIGATOR
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