Clinical trial NCT02664376: Prevalence of Sarcopenia and Its Geriatric Features
Official title: Prevalence of Sarcopenia and Its Geriatric Features
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sarcopenia
Keywords: sarcopenia
geriatry
Lead sponsor: Brugmann University Hospital
Sponsor class: OTHER
First posted: 2016-01-27
Enrollment: 834
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Each patient over 65 years admitted to the unit 83 of the Geriatric Department, CHU Brugmann Hospital, from 10/01/2016 till 30/03/2017 undergoes a comprehensive geriatric assessment at the end of its hospitalisation stay. The screening for sarcopenia is part of this geriatric assessment.

Brief summary: The goal of this study is to determine the prevalence of sarcopenia in a geriatric hospital ward.

Sarcopenia is defined by a loss of muscle mass, loss of muscle strength and loss of muscle quality. It is a geriatric syndrome that, to this date, is not systematically tracked in clinical practice.

In order to detect sarcopenia, the investigators will use the operational definition proposed by the European Working Group (EWGSOP) involving the measure of three parameters, namely the speed of walking, the muscle strength and the measurement of the muscular mass.


Eligibility criteria: Inclusion Criteria:

* To be admitted in the unit 83 of the Geriatric Departement of the CHU Brugmann hospital, from 10/01/2016 till 30/03/2017.

Exclusion Criteria:

* Patients unable to consent or without representatives
* Patients unable to perform the hand- grip test, the walk test or measurement of the body components by DEXA
* Patients in severe pain
* Bedridden patients
* Patients for which a clear therapeutic abstention has been established
* Language barriere that cannot be overcome
* Patients unable to walk without the help of a third person

Primary outcomes:
measure: Prevalence of sarcopenia
timeFrame: From 10/01/2016 till 30/03/2017 (up to 15 months)
Secondary outcomes:
measure: Percentage of hospitalized patients unable to perform the sarcopenia detection test
timeFrame: From 10/01/2016 till 30/03/2017 (up to 15 months)
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: CHU Brugmann
Study officials:
affiliation: CHU Brugmann
name: Robin Barré, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: CHU Brugmann
name: Murielle Surquin, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: CHU Brugmann
name: Florence Benoît, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: CHU Brugmann
name: Marie Claessens, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul;39(4):412-23. doi: 10.1093/ageing/afq034. Epub 2010 Apr 13.
citation: Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998 Apr 15;147(8):755-63. doi: 10.1093/oxfordjournals.aje.a009520.
citation: Cesari M, Kritchevsky SB, Newman AB, Simonsick EM, Harris TB, Penninx BW, Brach JS, Tylavsky FA, Satterfield S, Bauer DC, Rubin SM, Visser M, Pahor M; Health, Aging and Body Composition Study. Added value of physical performance measures in predicting adverse health-related events: results from the Health, Aging And Body Composition Study. J Am Geriatr Soc. 2009 Feb;57(2):251-9. doi: 10.1111/j.1532-5415.2008.02126.x.
citation: Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, Corsi AM, Rantanen T, Guralnik JM, Ferrucci L. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol (1985). 2003 Nov;95(5):1851-60. doi: 10.1152/japplphysiol.00246.2003.