Clinical trial NCT05539508: Role of Peripheral Vision in Scene Perception (PERISCE)
Official title: Role of Peripheral Vision in Scene Perception
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Primary Open-angle Glaucoma (POAG)
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2022-09-14
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: POAG patients and age-matched normally sighted controls

Brief summary: Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). This first representation would then trigger predictive mechanisms which would subsequently guide a more detailed visual analysis in central vision. The psychophysical studies that the investigators have already conducted in this scientific context has been carried out under normal vision conditions. The objective of this project is to study the influence of peripheral vision on central vision with an original approach: What are the consequences of a loss of peripheral vision on the processing performed in central vision? The project will concern patients with glaucoma. This ophthalmic pathology particularly affects the peripheral retina and thus represents a good pathological cognitive model of a visual recognition system in which peripheral vision is less important. The investigators will conduct psychophysical studies with glaucomatous patients and healthy volunteers with normal vision. All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. Participants will have to perform various tasks on these images using the keys on the keyboard.


Eligibility criteria: Inclusion Criteria:

For patients :

* between 18 and 80 years old
* stable bilateral primary open angle glaucoma (POAG)
* visual acuity \> 5/10 for distant vision for the eye tested
* peripheral visual field defect on the eye tested measured through a Humphrey Visual Field Analyzer

For healthy volunteers :

* between 18 and 80 years old
* visual acuity \> 5/10
* absence of ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy ...)

Exclusion Criteria:

* ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy ...)
* treated with medication that might compromise sustained attention (benzodiazepine, narcoleptics)

Primary outcomes:
measure: Psychophysical measure : Percentage of correct response
timeFrame: Through study completion of 45 months
measure: Psychophysical measure : Mean reaction time in milliseconds
timeFrame: Through study completion of 45 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Roux-Sibilon A, Rutge F, Aptel F, Attye A, Guyader N, Boucart M, Chiquet C, Peyrin C. Scene and human face recognition in the central vision of patients with glaucoma. PLoS One. 2018 Feb 26;13(2):e0193465. doi: 10.1371/journal.pone.0193465. eCollection 2018.
citation: Roux-Sibilon A, Trouilloud A, Kauffmann L, Guyader N, Mermillod M, Peyrin C. Influence of peripheral vision on object categorization in central vision. J Vis. 2019 Dec 2;19(14):7. doi: 10.1167/19.14.7.
citation: Peyrin C, Roux-Sibilon A, Trouilloud A, Khazaz S, Joly M, Pichat C, Boucart M, Krainik A, Kauffmann L. Semantic and Physical Properties of Peripheral Vision Are Used for Scene Categorization in Central Vision. J Cogn Neurosci. 2021 Feb 11:1-15. doi: 10.1162/jocn_a_01689. Online ahead of print.