louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06082908: Geriatric Syndrome in Nursing Home Residents
Official title: Predictors of the Disability in Nursing Home Residents: a Descriptive Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Disability Physical
Keywords: geriatric assessment
activities of daily living
nutritional deficiency
functional dependence
urinary incontinence
Lead sponsor: Giresun University
Sponsor class: OTHER
First posted: 2023-10-13
Enrollment: 124
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This cross-sectional study was conducted in nursing homes located in two cities.

Brief summary: Disability in daily living activities (ADL) is a typical issue among nursing care residents. The goal of this study was to look at the geriatric syndromes that cause incapacity in nursing home residents.

Detailed description: More often than not, people who live in nursing homes can't move out. One of the main reasons they leave their own home is to lose their freedom. Nursing homes also have a lot of people with geriatric diseases like cognitive impairment, balance problems, urinary incontinence, and disability. But it's not known what role geriatric syndromes play in ADL impairment. To come up with good ways to treat geriatric syndromes, which are the main causes of ADL disability in nursing home patients, we need to know more about them. So, the point of this study was to look into geriatric syndromes that are linked to disability and find out what causes disability in nursing home patients.

Eligibility criteria: Inclusion Criteria:

* age over 65
* staying in a nursing home for at least 12 months
* consent to participate in the study were the inclusion criteria.

Exclusion Criteria:

* people who were mentally unable to answer questions,
* people who were hospitalized
* people who had severe hearing or vision problems that made it hard to communicate
* people who took benzodiazepines or psychotropic drugs that made it hard to walk or balance
* people who had fractures or endoprostheses in any part of their bodies.

Primary outcomes:
measure: frailty
timeFrame: 5 minute
measure: disability
timeFrame: 5 minute
Secondary outcomes:
measure: sarcopenia
timeFrame: 5 minute
Other outcomes:
Locations:
city: Giresun
country: Turkey
facility: Giresun University
Study officials:
affiliation: Giresun University
name: ULKU K SAHIN, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Vermeulen J, Neyens JC, van Rossum E, Spreeuwenberg MD, de Witte LP. Predicting ADL disability in community-dwelling elderly people using physical frailty indicators: a systematic review. BMC Geriatr. 2011 Jul 1;11:33. doi: 10.1186/1471-2318-11-33.
citation: Jenkins KR, Fultz NH. Functional impairment as a risk factor for urinary incontinence among older Americans. Neurourol Urodyn. 2005;24(1):51-5. doi: 10.1002/nau.20089.
Clinical trial NCT02355808: Do Superfast Broadband and Tailored Interventions Improve Use of E-health and Reduce Health Related Travel?
Official title: Do Superfast Broadband and Tailored Interventions Improve Use of E-health and Reduce Health Related Travel?
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: eHealth
Lead sponsor: University of Plymouth
Sponsor class: OTHER
Collaborators: name: Superfast Cornwall
First posted: 2015-02-04
Enrollment: 1044
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: BASIC_SCIENCE

Brief summary: Lack of internet infrastructure, personal skills, and service provision have been identified as potential barriers to e-health but as yet there is no good evidence of the impact of interventions to improve them. This study aims to assess impact on e-health uptake of three interventions (i) superfast broadband, (ii) a tailored leaflet to help participants improve personal internet skills and support, (iii) GP interventions to improve health service provision of e-health. In a cluster randomised factorial controlled trial, 1388 households from 78 postcodes were randomly selected from the 20088 Cornish postcodes and allocated to the 8 (2X2X2) arms of the study. Comparison of 'e-health readiness' and 'miles travelled' from baseline to 18 month follow-up between the 8 arms of the study, will be used to assess the effects of interventions, singly and in combination.


Eligibility criteria: Inclusion Criteria:

* 16+ and member of randomly selected household within Cornwall

Exclusion Criteria:

* Non Cornish households

Primary outcomes:
measure: PERQ Ehealth score
timeFrame: 18 month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Abbott-Garner P, Richardson J, Jones RB. The Impact of Superfast Broadband, Tailored Booklets for Households, and Discussions With General Practitioners on Personal Electronic Health Readiness: Cluster Factorial Quasi-Randomized Control Trial. J Med Internet Res. 2019 Mar 11;21(3):e11386. doi: 10.2196/11386.
Clinical trial NCT06982508: Evaluation of Obicetrapib on Antioxidant Levels in Plasma and HDL Particles of Healthy Volunteers
Official title: A Randomized, Double-Blind, Placebo-Controlled Parallel Trial to Assess the Effects of Obicetrapib on Levels of Antioxidants in Plasma and HDL Particles in Healthy Volunteers: The VERMEER Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE2
Conditions: Antioxidant Absorption
Keywords: Healthy Volunteer
Lead sponsor: NewAmsterdam Pharma
Sponsor class: INDUSTRY
Collaborators: name: MB Clinical Research and Consulting LLC
First posted: 2025-05-21
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The goal of this clinical trial is to learn if Obicetrapib works to change antioxidant levels in HDL and plasma, as well as retinal tissue. The main questions it aims to answer are:

Do Obicetrapib effect absorption of antioxidants in a person's blood or their eye tissue? Researchers will compare Obicetrapib to a placebo (a look-alike substance that contains no drug) to see if Obicetrapib helps improve a person's ability to absorb antioxidants.

Participants will:

Take Obicetrapib or a placebo every day for 4 months Visit the clinic once every 8 weeks for checkups and tests Have their blood taken and their eyes checked to measure antioxidant levels


Eligibility criteria: Inclusion Criteria:

* Visual acuity \> 20/60 in both eyes with or without corrective lenses

Exclusion Criteria:

* Type 2 diabetes
* Active liver disease
* Any clinically significant macular pathology

Primary outcomes:
measure: Sum of Percent Change of Antioxidant Levels within HDL
timeFrame: 16 Weeks
Secondary outcomes:
measure: Effects of Obicetrapib on Percent Changes of Antioxidant Levels in Retinal Tissue, Plasma, and HDL Particles
timeFrame: 8 and 16 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05318508: Sagittal Spinopelvic Parameters in Patients With Lower Extremity Amputation
Official title: Sagittal Spinopelvic Parameters in Patients With Lower Extremity Amputation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Amputation, Traumatic
Low Back Pain
Lead sponsor: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Sponsor class: OTHER
First posted: 2022-04-08
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Lower extremity amputation

Brief summary: The aim of this study is to investigate the relationship between sagittal spinopelvic parameters and low back pain and quality of life in individuals with lower extremity amputation.

Detailed description: Low back pain is one of the secondary health problems that negatively affect functionality, independence and quality of life in individuals with lower extremity amputation. The prevalence of low back pain was reported to be higher in individuals with lower extremity amputation (52-89%) than in the non-amputee population (12-45%). Although the etiology of low back pain is multifactorial, changing anatomy and biomechanics after lower extremity amputation and maintaining daily activities are often associated with the development of low back pain. Postural imbalance, which is one of the musculoskeletal disorders of the spine that contributes to low back pain, is considered to cause additional load on the spinal structures.

Eligibility criteria: Inclusion Criteria:

* Patients aged ≥ 18 and ≤ 65 years
* Patients followed for at least 12 months with lower extremity amputation
* Patients who have been using prosthesis for at least 3 months
* Patients with stable medical and psychological status
* Patients willing to participate in the study

Exclusion Criteria:

* Patients with serious cardiovascular, pulmonary, neurological disease or other musculoskeletal problems (inflammatory rheumatic disease, active synovitis, severe low back pain, hip/knee joint replacement or other hip/knee-related trauma, fracture, or surgery) that impair walking
* Patients with severe vision, hearing and language problems

Primary outcomes:
measure: Thoracic kyphosis
timeFrame: baseline
Secondary outcomes:
measure: Cervical lordosis
timeFrame: baseline
measure: Lumbar lordosis
timeFrame: baseline
measure: Pelvic tilt
timeFrame: baseline
measure: Pelvic incidence
timeFrame: baseline
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Study officials:
References:
Clinical trial NCT04012008: Standard Versus Comprehensive Care for Post Acute Kidney Injury
Official title: Standard Versus Comprehensive Care for Post Acute Kidney Injury: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acute Kidney Injury
Lead sponsor: Chulalongkorn University
Sponsor class: OTHER
First posted: 2019-07-09
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The investigators aim to compare between standard versus comprehensive care for post-acute kidney injury who are admitted with acute kidney injury at least stage 2 or receive renal replacement therapy.


Eligibility criteria: Inclusion Criteria:

* Acute kidney injury at least stage 2 OR
* Received renal replacement therapy

Exclusion Criteria:

* Post kidney transplantation
* End-stage renal disease

Primary outcomes:
measure: 1 year major adverse kidney events
timeFrame: 1-year
Secondary outcomes:
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Chulalongkorn University
Study officials:
References:
citation: Thanapongsatorn P, Chaikomon K, Lumlertgul N, Yimsangyad K, Leewongworasingh A, Kulvichit W, Sirivongrangson P, Peerapornratana S, Chaijamorn W, Avihingsanon Y, Srisawat N. Comprehensive versus standard care in post-severe acute kidney injury survivors, a randomized controlled trial. Crit Care. 2021 Aug 31;25(1):322. doi: 10.1186/s13054-021-03747-7.
Clinical trial NCT06510608: Periodontal Disease and Salivary Mitofusin Levels
Official title: Evaluation of the Roles of Salivary Mitofusin-1 and Mitofusin-2 Levels in Periodontal Disease
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Periodontitis
Periodontal Diseases
Gingivitis
Lead sponsor: Erzincan University
Sponsor class: OTHER
First posted: 2024-07-19
Enrollment: 81
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with gingivitis and periodontitis presenting to the periodontology clinic, as well as healthy individuals

Brief summary: The aim of this observational study is to find out whether there is a level difference in salivary mitofusin-1 and mitofusin-2 levels due to changes in periodontal status. The main question it aims to answer is:

* Do salivary mitofusin-1 and mitofusin-2 levels of periodontitis patients differ from healthy patients?
* Could salivary mitofusin-1 and mitofusin-2 levels be biomarkers for periodontal disease?

Biochemical analysis will be performed on saliva samples taken at once from gingivitis or periodontitis patients and healthy individuals who apply to the periodontology clinic, at the initial stage of the treatment. There is no ongoing monitoring or second sampling.


Eligibility criteria: Inclusion Criteria:

* Being between the ages of 18 and 65.
* Willing to participate in the study and provide a saliva sample.
* Having a healthy periodontal condition, gingivitis, or periodontitis (Stage 3-4, Grade C).
* Having fasted from any food or drink (except water) for the past 2 hours prior to providing the saliva sample.
* Having refrained from brushing teeth or using mouthwash in the past 2 hours prior to providing the saliva sample.
* Not having any systemic diseases.
* Not currently taking any medications regularly.

Exclusion Criteria:

* Having used antibiotics within the last 6 months.
* Having received periodontal treatment within the last 6 months.
* Having fewer than 20 teeth (excluding third molars).
* Having any systemic diseases.
* Not smoking or having quit at least 5 years ago.

Primary outcomes:
measure: Mitofusin-1 concentration
timeFrame: Up to four weeks from start of work
measure: Mitofusin-2 concentration
timeFrame: Up to four weeks from start of work
measure: IL-1B concentration
timeFrame: Up to four weeks from start of work
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06671808: HIV and Multi-Drug Resistant Tuberculosis: a Study on Clinical Outcomes
Official title: HIV Infection Accompanied by Multi-Drug Resistant Tuberculosis: a Decadal Systematic Review and Meta-Analysis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: HIV Infection
MDR-TB
Lead sponsor: Zahedan University of Medical Sciences
Sponsor class: OTHER
First posted: 2024-11-04
Enrollment: 222128
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population consists of adult individuals (aged 18 years and older) diagnosed with both HIV infection and multi-drug-resistant tuberculosis (MDR-TB). This meta-analysis synthesizes data from various studies conducted across multiple countries, including Brazil, the USA, Canada, India, Ethiopia, and several others. The population includes a diverse cohort of patients, reflecting various demographic characteristics such as age, sex, and geographical location.

The studies included in this meta-analysis feature participants with confirmed diagnoses of HIV and MDR-TB, with a focus on understanding the co-infection dynamics, treatment outcomes, and associated health challenges. Data extraction from these studies provides insight into the prevalence and impact of MDR-TB among HIV-positive patients, highlighting the importance of tailored

Brief summary: This study aims to investigate the relationship between HIV infection and multi-drug resistant tuberculosis (MDR-TB) among affected individuals in Zahedan, Iran. It will involve a detailed analysis of patient demographics, clinical characteristics, and treatment outcomes to enhance understanding of this co-infection. The findings may inform better treatment strategies and healthcare policies for managing these diseases in similar populations.


Eligibility criteria: Inclusion Criteria:

* Adults (aged 18 years and older) diagnosed with both HIV and multi-drug-resistant tuberculosis (MDR-TB).
* Studies published in peer-reviewed journals.
* Studies that provide data on the co-occurrence of HIV and MDR-TB.
* Participants from diverse geographical regions to enhance generalizability.
* Studies with clear definitions of MDR-TB according to WHO guidelines.

Exclusion Criteria:

* Studies that focus solely on drug-susceptible tuberculosis without MDR-TB.
* Studies involving pediatric populations (under 18 years of age).
* Non-original research such as reviews, editorials, and commentaries.
* Studies lacking sufficient data on the co-occurrence of HIV and MDR-TB.
* Studies that do not adhere to ethical guidelines for human subjects or lack appropriate ethical approvals.

Primary outcomes:
measure: Prevalence of Multi-Drug Resistant Tuberculosis (MDR-TB) in HIV-Positive Patients
timeFrame: Data collected over the course of the studies from 2006 to 2018.
Secondary outcomes:
Other outcomes:
Locations:
city: Zahedan
country: Iran, Islamic Republic of
facility: Zahedan University of Medical Sciences
state: Sistan and Baluchestan
Study officials:
References:
Clinical trial NCT01297608: A Double Blinded Study to Examine the Effect of Coated Suppositories on Fecal Incontinence in Patients With Spinal Cord Injury
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
Conditions: Fecal Incontinenece
Lead sponsor: RDD Pharma Ltd
Sponsor class: INDUSTRY
First posted: 2011-02-17
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This is a double blinded cross over study. Approximately 20 spinal cord injury patients will be participating in this 4 weeks study.The primary outcome is difference in fecal incontinence as recorded in diaries, between the treatment period and the treatment period.


Eligibility criteria: Inclusion Criteria:

Signed written informed consent; Male or female subjects 18 to 55 years of age; Spinal cord lesion/disease/injury at any level at least 3 months from injury. FISI (Fecal Incontinence Severity Index) \> 8 units. The patient is able to understand the treatment and is willing to comply with the prescribed regimen

Exclusion Criteria:

* Known allergy to experimental drug..
* Porphiria.
* Glaucoma.
* Pregnancy or lactation.
* Active or past history of cardiovascular or cerebrovascular disease including unstable angina, myocardial infarction, transient ischemic attacks/stroke, clinically significant arrhythmia, congestive heart failure, or cardiac valve abnormalities;
* Type 1 diabetes mellitus;
* Insulin treated type 2 diabetes mellitus.
* Renal insufficiency.
* Liver insufficiency.
* Malignant disease within 5 years of screening;
* Has hypertension (sitting blood pressure \> 140/90 mmHg at screening)
* History of rectal surgery.
* History of HIV, hepatitis B, hepatitis.
* Has used, in the last four weeks, drugs that may affect blood coagulation, such as Aspirin (at a dose above 250 mg/day), Warfarin, Sintrom, Enoxaparin, Nadroparin, Heparin, Clopidogrel, Ticlopidine.
* Use of tricyclic or monoamine-oxidase inhibors.
* Has upon physical examination a rectal deformation or signs of rectal disease such as fissure, bleeding hemorrhoids, fistula, infection or space occupying lesion.
* Unable to understand the use instruction for the coated suppository, as judged by the investigator.

Primary outcomes:
measure: fecal incontinence
timeFrame: 2 weeks
Secondary outcomes:
measure: quality of life
timeFrame: 2 weeks
Other outcomes:
Locations:
city: Zrifin
country: Israel
facility: Gastroeneterology dept, Asaf harofe Medical center
Study officials:
References:
Clinical trial NCT06898008: Characterization of Children with Complaints of Excessive Daytime Sleepiness
Official title: Characterization of Children with Complaints of Excessive Daytime Sleepiness
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Excessive Daytime Sleepiness
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2025-03-27
Enrollment: 400
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients at the HFME university hospital center, third-line referral center for the Auvergne-Rhônes-Alpes region (France)

Brief summary: 10% of the population suffers from excessive daytime sleepiness. This can be explained by a variety of etiologies: psychiatric disorders, altered sleep quantity or quality, hypersomnia... The consequences on quality of life are not negligible, with emotional, academic, social, financial and somatic repercussions. Diagnosing and managing them is essential. This is the role of the HFME's Child Sleep Service, a reference center for rare narcolepsy and hypersomnia, which carries out a weekly hypersomnia assessment. In this context, the investigators are carrying out a retrospective descriptive study, the primary objective of which is to describe the results and diagnoses of hypersomnia check-ups in the HFME's Sleep Department, in order to obtain feedback on the center's activity and its evolution.

The secondary objectives are to characterize the patients in the different diagnostic groups, to highlight factors associated with the different diagnoses, and to describe changes in patient characteristics over time.


Eligibility criteria: Inclusion Criteria:

* - Patient hospitalized in the HFME sleep department for a "diagnostic assessment of hypersomnia".
* Age under 18 at the time of hospitalization
* From January 2015 to December 2023

Exclusion Criteria:

* - No balance sheet
* Age over 18 at time of hospitalization
* Assessment for medicolegal or therapeutic adaptation purposes

Primary outcomes:
measure: Describe the results and diagnoses of hypersomnia assessments in the HFME Sleep Department
timeFrame: Feedback consultation 1 month after inpatient assessment
Secondary outcomes:
Other outcomes:
Locations:
city: France
country: France
facility: Service d'épileptologie clinique, des troubles du sommeil et de neurologie fonctionnelle de l'enfant - Hôpital Femme Mère Enfant
state: Bron
Study officials:
References: