Clinical trial NCT01517581: Brown Fat Activity and White Fat Accumulation
Official title: Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hodgkins Lymphoma
Non-hodgkins Lymphoma
Keywords: Brown adipose tissue
Lead sponsor: Children's Hospital Los Angeles
Sponsor class: OTHER
First posted: 2012-01-25
Enrollment: 32
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pediatric patients with a history of malignancy such that they are required to undergo PET/CT exams.

Brief summary: White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.


Eligibility criteria: Inclusion Criteria:

* Patients had PET/CT scans with evidence of malignant disease
* Patients had no metabolically active BAT at diagnosis on their PET/CT scan
* Patients were disease free within 1 year of diagnosis

Exclusion Criteria:

* Patients had PET/CT scans with no evidence of malignant disease
* Patients with metabolically active BAT at diagnosis on their PET/CT scan
* Patients were not disease free within 1 year of diagnosis

Primary outcomes:
measure: Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up
timeFrame: Baseline and up to 1 year
measure: Change from Baseline in Visceral Adipose Tissue Volume at Follow-up
timeFrame: Baseline and up to 1 year
measure: Change from Baseline in Presence of Brown Adipose Tissue
timeFrame: Baseline and up to 1 year
measure: Change from Baseline in Abdominal Musculature Volume
timeFrame: Baseline and up to 1 year
Secondary outcomes:
measure: Change from Baseline in Anthropometric Measures at Follow-up
timeFrame: Baseline and up to 1 year
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Children's Hospital Los Angeles
state: California
Study officials:
affiliation: Children's Hospital Los Angeles
name: Vicente Gilsanz, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hamilton G, Smith DL Jr, Bydder M, Nayak KS, Hu HH. MR properties of brown and white adipose tissues. J Magn Reson Imaging. 2011 Aug;34(2):468-73. doi: 10.1002/jmri.22623.
citation: Gilsanz V, Chung SA, Jackson H, Dorey FJ, Hu HH. Functional brown adipose tissue is related to muscle volume in children and adolescents. J Pediatr. 2011 May;158(5):722-6. doi: 10.1016/j.jpeds.2010.11.020. Epub 2010 Dec 18.
citation: Gilsanz V, Smith ML, Goodarzian F, Kim M, Wren TA, Hu HH. Changes in brown adipose tissue in boys and girls during childhood and puberty. J Pediatr. 2012 Apr;160(4):604-609.e1. doi: 10.1016/j.jpeds.2011.09.035. Epub 2011 Nov 1.
citation: Gilsanz V, Chung SA, Kaplowitz N. Differential effect of gender on hepatic fat. Pediatr Radiol. 2011 Sep;41(9):1146-53. doi: 10.1007/s00247-011-2021-7. Epub 2011 Mar 15.
citation: Hu HH, Chung SA, Nayak KS, Jackson HA, Gilsanz V. Differential computed tomographic attenuation of metabolically active and inactive adipose tissues: preliminary findings. J Comput Assist Tomogr. 2011 Jan-Feb;35(1):65-71. doi: 10.1097/RCT.0b013e3181fc2150.
citation: Chalfant JS, Smith ML, Hu HH, Dorey FJ, Goodarzian F, Fu CH, Gilsanz V. Inverse association between brown adipose tissue activation and white adipose tissue accumulation in successfully treated pediatric malignancy. Am J Clin Nutr. 2012 May;95(5):1144-9. doi: 10.3945/ajcn.111.030650. Epub 2012 Mar 28.