louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06344455: Influence of Educational Stimuli From the Pé-de-Meia Program on Delay Discounting Propensity
Official title: Influence of Educational Stimuli From the Pé-de-Meia Program on Delay Discounting Propensity: A Study With the Modified Iowa Gambling Task
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Delay Discounting
Lead sponsor: Federal Institute of Education, Science and Technology of the State of Mato Grosso
Sponsor class: OTHER
First posted: 2024-04-03
Enrollment: 120
Sex: ALL
Minimum age (years): 14
Maximum age (years): 24
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this randomized clinical trial is to investigate how the Stay-and-Complete School Incentive Savings, part of the Pé-de-Meia Program, affects decision-making among low-income high school students, particularly their tendency towards delay discounting. This concept describes the preference for immediate gratifications over larger future rewards. The main questions it seeks to answer are:

Can exposure to the specific educational stimuli of the Pé-de-Meia Program alter students' propensity for delay discounting? How do different levels of delay discounting influence students' decision-making regarding their studies and the utilization of the program's incentives?

Participants will:

Engage in a modified version of the Iowa Gambling Task (IGT), a computerized game that simulates decision-making under uncertainty, adapted to reflect the stimuli and choices related to the Pé-de-Meia Program.

Complete questionnaires that measure their propensity for delay discounting and gather demographic and socioeconomic information.

Researchers will compare the outcomes among groups of students exposed to different types of stimuli (aligned with the program's objectives, contrasting, and a control group without modifications) to see if the specific financial and educational incentives of the Pé-de-Meia Program influence how students value immediate rewards compared to future benefits. This study is expected to contribute to the improvement of public educational policies, encouraging school retention and promoting the educational success of low-income adolescents.


Eligibility criteria: Inclusion Criteria:

* Low-income high school students in the public system, registered in CadÚnico

Exclusion Criteria:

* Students with a formal psychological or psychiatric diagnosis

Primary outcomes:
measure: Delay Discounting 1
timeFrame: up to 12 weeks
measure: Delay Discounting 2
timeFrame: up to 24 weeks
Secondary outcomes:
measure: decision-making performance under risk and uncertainty
timeFrame: up to 24 weeks
measure: loss aversion
timeFrame: up to 24 weeks
measure: Loss Frequency-Based Decision Strategy
timeFrame: up to 24 weeks
measure: Learning
timeFrame: up to 24 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05937555: Professional Bladder Cancers and the Profession of Painter
Official title: Professional Bladder Cancers and the Profession of Painter: Retrospective Study of the RNV3P Database Files
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bladder Cancer
Keywords: painter
occupational cancer
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2023-07-10
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: workers with occupational work tasks of painting with medical consultation for bladder cancer in a French occupational diseases center

Brief summary: This is a retrospective study on bladder cancer in French painters' population. The French agency ANSES collected data from all occupational and environmental diseases center in a specific database called RNV3P. We selected cases of bladder cancer in painters in four centers from 01/01/2010 to 31/12/2019. Those cases were analyzed in terms of occupational exposure, histology and sociodemographics data. Comparison between different histologic types of cancer, workplaces and occupational diseases process will be done.


Eligibility criteria: Inclusion Criteria:

* painters
* age\> 18 years
* data from one of the French occupational diseases centers
* approval letter

Exclusion Criteria:

* non-approval letter
* age \< 18 years

Primary outcomes:
measure: histological type of bladder cancer
timeFrame: Inclusion ( Day 0)
Secondary outcomes:
measure: Occupational exposures
timeFrame: Inclusion (Day 0)
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU de Brest
city: Caen
country: France
facility: CHU de Caen
city: Cherbourg
country: France
facility: Ch Cherbourg
city: Le Havre
country: France
facility: CH le Havre
city: Lille
country: France
facility: CHU de Lille
city: Rouen
country: France
facility: CHU de Rouen
Study officials:
References:
Clinical trial NCT06340555: Intervention to Prevent Mental Health Disorders of Women and Their Partners Who Experienced Pregnancy Loss
Official title: Multiprofessional Healthcare Intervention to Prevent Mental Health Disorders of Women and Their Partners Who Experienced Pregnancy Loss (Enzo Study): A Hybrid Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Stillbirth and Fetal Death
Lead sponsor: Fundació Sant Joan de Déu
Sponsor class: OTHER
Collaborators: name: University of Barcelona
name: University of Seville
First posted: 2024-04-01
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The goal of this clinical trial is to test impact of a multiprofessional intervention in mothers and partners who suffer a pregnancy loss. The main questions it aims to answer are:

* impact on mothers and partners mental heatlht status
* reasons why mothers do not consent to the intervention

Participants will:

* mothers and partners will complete 4 scales
* mothers and partners will participate in a interview

Researchers will compare with mothers with standard care to see if the multiprofessional intervention has an impact.

Detailed description: Objective 1: Evaluate the effectiveness of the multi professional intervention to reduce the intensity of grief, depression, anxiety and PTSD symptoms in women and their partners after pregnancy loss.

Objective 2: Assess the extent to which the multiprofessional intervention was implemented as intended (fidelity) and understand how the intervention becomes integrated into routine healthcare practice (implementation).

Eligibility criteria: Inclusion Criteria:

* Women and their partners who suffer a pregnancy loss
* Health professionals who have worked for at least 1 year in the hospital studied

Exclusion Criteria:

* Participants who do not understand spanish/catalan

Primary outcomes:
measure: Intensity of grief
timeFrame: 6 months
Secondary outcomes:
measure: Depressive symptoms
timeFrame: 6 months
measure: Anxiety symptoms
timeFrame: 6 months
measure: Perinatal postraumatic stress disorder
timeFrame: 6 months
Other outcomes:
Locations:
city: Sant Boi De Llobregat
country: Spain
facility: Parc Sanitari Sant Joan de Deu
state: Barcelona
Study officials:
References:
Clinical trial NCT05453955: Effect of Remimazolam on Motor Evoked Potential
Official title: Influence of Propofol and Remimazolam on Intraoperative Responses of Motor Evoked Potentials During Spine Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Spine Disease
Lead sponsor: Korea University Guro Hospital
Sponsor class: OTHER
First posted: 2022-07-12
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: This study was planned to investigate the degree of effect of remimazolam on MEP compared to propofol when monitoring the motion-inducing potential (MEP).


Eligibility criteria: Inclusion Criteria:

* Aged 20-70
* Scheduled for elective spine surgery requiring monitoring of evoked potential
* ASA physical status 1-3

Exclusion Criteria:

* BMI ≥ 40
* Uncontrolled DM (HbA1c ≥ 9%)
* Contraindications to the study drug: known allergy or hypersensitivity
* Use of rate responsive cardiac pacemaker with bioelectrical impedence
* Diagnosed neuromuscular disorder
* Pre-existing motor weakness

Primary outcomes:
measure: Motor evoked potential (MEP), before cross-over
timeFrame: Intraoperative, just after confirmation of neuromuscular recovery, for 30 minutes
measure: MEP, after cross-over
timeFrame: Intraoperative, 30 minutes after alteration of the maintenance drug, for 30 minutes
Secondary outcomes:
measure: Bispectral index
timeFrame: Intraoperative
measure: Blood pressure
timeFrame: Intraoperative
measure: Heart rate
timeFrame: Intraoperative
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seok Kyeong Oh
state: Gangnam-gu
Study officials:
affiliation: Korea University Guro Hospital
name: Sang Sik Choi, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00168155: Study of 5-FU + Leucovorin + CPT-11 in Patients With Resectable Liver Metastases From Colorectal Adenocarcinoma
Official title: Phase 2 Study of Neoadjuvant 5-FU + Leucovorin + CPT-11 in Patients With Resectable Liver Metastases From Colorectal Adenocarcinoma
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Colorectal Adenocarcinoma
Liver Metastases
Keywords: resectable liver metastases
colorectal adenocarcinoma
survival
neoadjuvant chemotherapy
Lead sponsor: AHS Cancer Control Alberta
Sponsor class: OTHER
Collaborators: name: Pfizer
First posted: 2005-09-15
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: When colon or rectal cancer has spread to the liver, the cancer in the liver can sometimes be removed surgically. However, the cancer has a chance or reoccurring in the liver or elsewhere in the body. This study will determine if giving chemotherapy treatment before the surgery can reduce the chances that the cancer will come back.

Detailed description: When colon or rectal cancer has spread to the liver, the cancer in the liver can sometimes be removed surgically. However, the cancer has a chance or reoccurring in the liver or elsewhere in the body. This study will determine if giving chemotherapy treatment before the surgery can reduce the chances that the cancer will come back.

Eligibility criteria: Inclusion Criteria:

* stage IV colorectal cancer isolated to the liver
* one measurable lesion
* metastases are completely resectable or amenable to ablation
* Karnofsky \>70
* Adequate bone marrow function
* adequate hepatic function
* adequate renal function
* informed consent

Exclusion Criteria:

* primary tumor not controlled by locoregional treatments
* bilateral portal vein and/or hepatic artery involvement
* previous chemotherapy directed at treatment of metastatic colorectal cancer
* underlying acute or chronic liver disease
* Gilbert's disease
* patients receiving phenytoin or phenobarbital prophylaxis
* presence of any concurrent medical or psychiatric condition that serves as a contraindication to surgery or chemotherapy
* pregnancy
* malignancy other than basal cell or squamous cell carcinoma of the skin within the preceding 5 years
* use of another investigational medication concurrently or within 4 months of enrollment

Primary outcomes:
measure: disease free survival
Secondary outcomes:
Other outcomes:
Locations:
city: Calgary
country: Canada
facility: Tom Baker Cancer Centre
state: Alberta
Study officials:
affiliation: Alberta Health services
name: Oliver Bathe, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bathe OF, Ernst S, Sutherland FR, Dixon E, Butts C, Bigam D, Holland D, Porter GA, Koppel J, Dowden S. A phase II experience with neoadjuvant irinotecan (CPT-11), 5-fluorouracil (5-FU) and leucovorin (LV) for colorectal liver metastases. BMC Cancer. 2009 May 20;9:156. doi: 10.1186/1471-2407-9-156.
Clinical trial NCT06219655: Extended Versus Limited Thoracoscopic Sympathectomy: Its Impact on Palmar and Plantar Hyperhidrosis
Official title: Extended Versus Limited Thoracoscopic Sympathectomy: Its Impact on Palmar and Plantar Hyperhidrosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hyperhidrosis Due to Autonomic Dysregulation (Disorder)
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2024-01-23
Enrollment: 120
Sex: ALL
Minimum age (years): 6
Maximum age (years): 24
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Conclusions: In the context of palmar and plantar hyperhidrosis, extended thoracoscopic sympathectomy seemed to be preferred over limited thoracoscopic sympathectomy due to better overall outcomes and minimal time for hospital stays and Compensatory hyperhidrosis.

Detailed description: ABSTRACT Objective: The aim was to carefully evaluate and compare the results of extended sympathectomy versus T3, T4, and T5 resection in cases of palmer, axillary, and planter hyperhidrosis as regards decreased sweating and recurrence rates.

Methods: This was a randomized controlled prospective trial conducted at the Department of Vascular Surgery Mansoura University Hospitals on a total of 120 patients with hyperhidrosis who were divided into two groups; group 1 who had undergone limited sympathectomy and group 2 who had undergone extended sympathectomy.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of hyperhydrosis
* Able to take drugs
* Palmer and planter hyperhydrosis
* Age from 6-24 years
* Interfere with daily activities

Exclusion Criteria:

* Not fit for surgery
* Thyroid disease
* age less than 6 years
* Chest or cardiac problems

Primary outcomes:
measure: hyperhidrosis dryness of hands
timeFrame: from 2019-2023 over 4 years
measure: dryness of both feet
timeFrame: from 2019-2023 over 4 years
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mansoura University
Study officials:
References:
Clinical trial NCT01156155: Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis
Official title: Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rheumatoid Arthritis
Osteoarthritis
Periodontal Disease
Keywords: rheumatoid arthritis
osteoarthritis
periodontal disease
Lead sponsor: University of Nebraska
Sponsor class: OTHER
Collaborators: name: Dallas VA Medical Center
name: Washington D.C. Veterans Affairs Medical Center
name: VA Salt Lake City Health Care System
First posted: 2010-07-02
Enrollment: 617
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: UNebraskapatients Omaha VA Medical Center

Brief summary: Periodontitis (PD) has been postulated to be a risk factor for the onset and progression of rheumatoid arthritis (RA). Recent reports suggest that infection with Porphyromonas gingivalis (P. gingivalis), a major oral pathogen in PD, could play a pivotal role in the development RA. The objective of this study is to examine the relationship of PD and P. gingivalis infection with the risk and severity of RA.

Detailed description: In this study, we will examine whether periodontitis (PD) and P. gingivalis impact rheumatoid arthritis (RA) risk by enrolling 300 patients with RA and 300 comparator patients with osteoarthritis and comparing results from comprehensive dental examinations and antibody responses to P. gingivalis. We will examine whether these associations are modified by the presence of certain genetic risk factors previously implicated in RA and whether evidence of infection with P. gingivalis precedes RA onset by examining banked sera from the Department of Defense Serum Repository (DoDSR) and the Studies of the Etiology of RA (SERA). We also plan to explore whether there are novel proteins expressed by P. gingivalis that drive autoimmunity in RA and whether immune responses to these bacterial proteins predict the future development of RA.

Eligibility criteria: Inclusion Criteria:

* Age 19 years or older
* Diagnosis of rheumatoid arthritis, or osteoarthritis
* Have 9 or more evaluable posterior teeth (out of a total of 28 teeth, excluding third molars)
* Willing and able to provide informed consent

Exclusion Criteria:

* Received tetracyclines within the last 6 months.
* Need for antibiotic premedication for dental probing.
* Pregnant or breast feeding

Primary outcomes:
measure: Show the associations of periodontitis with RA are primarily due to infection with P. gingivalis
timeFrame: within thirty days of enrollment
Secondary outcomes:
Other outcomes:
Locations:
city: Omaha
country: United States
facility: Veterans Affairs Medical Center, Omaha
state: Nebraska
Study officials:
affiliation: University of Nebraska
name: Ted R Mikuls, MD, MSPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00749255: Collect Breast Cancer Patients' Digital Mammography Images With Corresponding Reports for the Development of Software
Official title: R2 Case Collection
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Breast Cancer
Keywords: Breast Cancer
Digital archiver software
Lead sponsor: WellSpan Health
Sponsor class: OTHER
First posted: 2008-09-09
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Known breast cancer patients

Brief summary: The purpose of this case collection effort is software design by R2 Technologies, Inc., The information received from Women's Imaging will be provided to the Case Collection, Data Management and Algorithm/software design and development teams who are responsible for the receipt of patient data and management of such data; and creation, testing and validation of R2 Technologies, Inc., for Computer Aided Detection (CAD) and new digital image archiving software design.

Detailed description: The information is necessary for Sponsor development efforts and will be utilized as a viewing tool with supporting written documentation of the findings on each image itself. The information will be used to develop algorithms that will foster development of CAD software. The information in each image and/or accompanying written clinical case documentation will not be analyzed in any way for clinical events

Eligibility criteria: Inclusion Criteria:

* subjects with known breast cancer ages 18 and over
* case images originating from Women's imaging or one of the affiliated screening centers. Raw images must be available for each image
* source documents or mammographic interpretation must be available

Exclusion Criteria:

* 17 or younger

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: York
country: United States
facility: Women's Imaging @ WellSpan Health
state: Pennsylvania
Study officials:
affiliation: Women's Imaging @ WellSpan Health
name: Misty Hicks, RTRM
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03229655: Evaluation of Sequential Stent Addition vs. Incremental Dilation & Stent Exchange for Management of Anastomotic Biliary Strictures After Liver Transplantation
Official title: Evaluation of Sequential Stent Addition vs. Incremental Dilation & Stent Exchange for Management of Anastomotic Biliary Strictures After Liver Transplantation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Anastomotic Stenosis
Biliary Stricture
Lead sponsor: Stanford University
Sponsor class: OTHER
Collaborators: name: University of Rochester
name: University of Barcelona
First posted: 2017-07-25
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized prospective study
Primary purpose: TREATMENT

Brief summary: Prospective, randomized comparison of the incremental dilation and stent exchange vs. sequential stent addition approaches for management of anastomotic biliary strictures will facilitate optimal management of patients who develop anastomotic biliary strictures after liver transplantation.


Eligibility criteria: Inclusion Criteria:

1. Age 18 and older
2. Clinical concern for anastomotic biliary stricture following liver transplantation (as determined by the referring transplant hepatologist)
3. Willing and able to comply with the study procedures and provide written informed consent to participate in the study.

Exclusion Criteria:

1. Age \<18
2. Potentially vulnerable subjects including, homeless people, pregnant females, employees and students.
3. Complex post-surgical anatomy e.g. Choledochojejunostomy, Billroth type II anatomy, Roux-en-Y-gastrojejunostomy
4. Participation in another investigational study that may directly or indirectly affect the results of this study within 30 days prior to the initial visit
5. Other biliary process which accounts for patient's abnormal liver function studies/imaging (i.e. significant non-anastomotic biliary stricture).

Primary outcomes:
measure: Anastomotic biliary stricture resolution
timeFrame: Immediately following final ERCP with stent removal
Secondary outcomes:
measure: Fluoroscopy Parameters
timeFrame: 1 day
measure: Adverse Events
timeFrame: 1 week
measure: Sustained resolution of anastomotic stricture for 6 months
timeFrame: 6 months after final study ERCP with stent removal
measure: Sustained resolution of anastomotic stricture for 12 months
timeFrame: 12 months after final study ERCP with stent removal
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University Medical Center
state: California
Study officials:
References: