Clinical trial NCT03327376: Daily Ultrasound-screening for CVC-related Thrombosis
Official title: Daily Ultrasound-screening for CVC-related Thrombosis in Intensive Care Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Central Venous Catheter Thrombosis
Critical Illness
Ultrasonography
Keywords: central venous catheters
venous thrombosis
ultrasound
critical care
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2017-10-31
Enrollment: 1262
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: We conduct an observational prospective multicenter study.The patients come from the ICUs of Zhejiang province.

Brief summary: The central venous catheters (CVC) related thrombosis is an issue of importance to ICU clinicians.This study conducts the daily ultrasound-screening for CVC-related thrombosis (DUCT).Its aim is to evaluate the characteristic and regularity of the central venous catheters (CVC) related thrombosis in ICU patients, and optimize the screening program of CVC-related thrombosis.


Eligibility criteria: Inclusion Criteria:

* Consecutive patients at least 18 years of age, expected to need a central venous catheterization for at least 48h in ICU.

Exclusion Criteria:

* Patients with infection or inflammation or local trauma at the insertion site.

Primary outcomes:
measure: the incidence rate of central venous catheters related thrombosis (CRT)
timeFrame: the assessment time will be from the time patients admitted in ICU to the time leaving ICU, less than 6 months.
Secondary outcomes:
measure: the time when the central venous catheters related thrombosis (CRT) occured
timeFrame: the assessment time will be from the time patients admitted in ICU to the time leaving ICU, less than 6 months.
Other outcomes:
Locations:
city: Hanzhou
country: China
facility: 2nd Affiliated Hospital, Zhejiang University School of Medicine Institute of Emergency Medicine, Zhejiang University
state: Zhejiang
Study officials:
affiliation: 2nd Affiliated Hospital, Zhejiang University School of Medicine Institute of Emergency Medicine, Zhejiang University
name: Mao Zhang, MD
role: STUDY_DIRECTOR
affiliation: The First People's Hospital of Fuyang District
name: Weidong Tang, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Beilun District People's Hospital
name: Zhiping Huang, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: The First People's Hospital of Huzhou
name: Zhaohui Ji, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Lishui Country People's Hospital
name: Hong Liu, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Zhejiang University of traditional Chinese Medicine
name: Lingcong Wang, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Jinhua Central Hospital
name: Mingwei Huang, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hunan People's Hospital
name: Xingwen Zhang, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Affiliated Hospital of Jiaxing University
name: Yunchao Shi, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Taizhou Hospital
name: Renfei Shan, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Taizhou Hospital of integrated traditional Chinese and Western Medicine
name: Fuzheng Tao, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: First People's Hospital of Hangzhou
name: Yi Wang, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Ninghai First Hospital
name: Qijiang Chen, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Lishui Country People's Hospital
name: Ning Zhang, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Pinghu first people's Hospital
name: Jian Hu, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Affiliated Hospital of Hangzhou Teacher's University
name: Dengpan Lai, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: First Affiliated Hospital of Wenzhou Medical University
name: Yingru Lu, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Ruian People's Hospital
name: Xudong Zheng, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: The First People's Hospital of Fuyang District
name: Jianbo Gao, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Jiande First People's Hospital
name: Bei Tang, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Taizhou Hospital
name: Wansheng Li, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Xiaoshan first people's Hospital
name: Xiaoyuan Shen, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Affiliated Wenling Hospital of Wenzhou Medical University
name: Yukang Song, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Shaoxing People's Hospital
name: Guojuan Ding, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Zhejiang Quhua Hospital
name: Feng Wu, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: The Central Hospital of Lishui City
name: Xin Tian, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: The Second Affiliated Hospital of Jiaxing University
name: Shaoyi Xu, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: The Central Hospital of Lishui City
name: Weijun Fang, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Yuyao People's Hospital
name: LIfeng Wu, MD
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Refaei M, Fernandes B, Brandwein J, Goodyear MD, Pokhrel A, Wu C. Incidence of catheter-related thrombosis in acute leukemia patients: a comparative, retrospective study of the safety of peripherally inserted vs. centrally inserted central venous catheters. Ann Hematol. 2016 Dec;95(12):2057-2064. doi: 10.1007/s00277-016-2798-4. Epub 2016 Aug 20.
citation: Parienti JJ, Mongardon N, Megarbane B, Mira JP, Kalfon P, Gros A, Marque S, Thuong M, Pottier V, Ramakers M, Savary B, Seguin A, Valette X, Terzi N, Sauneuf B, Cattoir V, Mermel LA, du Cheyron D; 3SITES Study Group. Intravascular Complications of Central Venous Catheterization by Insertion Site. N Engl J Med. 2015 Sep 24;373(13):1220-9. doi: 10.1056/NEJMoa1500964.
citation: Gentile A, Petit L, Masson F, Cottenceau V, Bertrand-Barat J, Freyburger G, Pinaquy C, Leger A, Cochard JF, Sztark F. Subclavian central venous catheter-related thrombosis in trauma patients: incidence, risk factors and influence of polyurethane type. Crit Care. 2013 May 29;17(3):R103. doi: 10.1186/cc12748.