Clinical trial NCT04541823: The Effect of Desflurane on Postopertative Cognitive Dysfunction
Official title: A Study Evaluating the Effect of Desflurane in Preventing Postoperative Cognitive Dysfunction
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Postoperative Cognitive Dysfunction
Postoperative Delirium
Lead sponsor: Beijing Chao Yang Hospital
Sponsor class: OTHER
First posted: 2020-09-09
Enrollment: 100
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine the effect of desflurane on postoperative cognitive dysfunction

Detailed description: Postoperative cognitive dysfunction is a common complication during postoperative period，especially in elderly patients. It is characterized by cognitive decline, inattention and abnormal mental status following surgery. The presence of postoperative cognitive dysfunction is independently associated with poor recovery, increased hospital length of stay and increased mortality.

Desflurane is a widely used volatile anesthetic, associated with shorter emergence times than other volatile anesthetics. This study aims to access the effect of desflurane in preventing postoperative cognitive dysfunction.

Eligibility criteria: Inclusion Criteria:

* 1. Written consent given
* 2. Scheduled to undergo elective non-cardiac surgeries under general anesthesia
* 3. ASA Physical Score I-III

Exclusion Criteria:

* 1. Patients with a history of neurological disease, such as Alzheimer disease.
* 2. Patients with a history of psychiatric disease
* 3. Patients with a medication history of antipsychotic drugs.
* 4. Unable to complete neuropsychological testing including patients with severe visual or hearing impairment.
* 5. Patients with preoperative delirium.
* 6. Patients who have severe adverse events, such as cardiac arrest.
* 7. Patients who preoperative MMSE score are below 20;
* 8. Patients who undergo second operation in a short period.

Primary outcomes:
measure: Incidence of postoperative cognitive dysfunction
timeFrame: on the 30th day after surgery
Secondary outcomes:
measure: Incidence of postoperative delirium
timeFrame: 1-7days after surgery, on the 30th day after surgery
measure: Postoperative Pain
timeFrame: Within 3 days after surgery
measure: EEG frequency spectrum
timeFrame: 5 minutes before anesthesia introduction to 5 minutes before discharge from PACU
measure: Mortality
timeFrame: Within 30 days after surgery
measure: Length of Hospital stay
timeFrame: From the date of admission until discharged from hospital, within 30 days
measure: Hospital readmission
timeFrame: Within 30 days after surgery
measure: Incidence of postoperative nausea and vomiting
timeFrame: Within 7 days after surgery
measure: Adverse events
timeFrame: Within 30 days after surgery
measure: Neural and hemodynamic responses during desflurane general anesthesia
timeFrame: 5 minutes before anesthesia introduction to 5 minutes after emergence
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Chaoyang Hospital, Capital Medical University
state: Beijing
Study officials:
References: