louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00901810: Clinical Evaluation of Working Length Determination by Electronic Apex-Locator or Radiography on Adequacy of Final Working Length
Official title: Clinical Evaluation of Working Length Determination by Electronic Apex-Locator or Radiography on Adequacy of Final Working Length
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Root Canal
Keywords: Length Determination
Working Length
Electronic Apex Locator
Root Canal Therapy
Endodontics
Lead sponsor: Shiraz University of Medical Sciences
Sponsor class: OTHER
First posted: 2009-05-14
Enrollment: 280
Sex: ALL
Minimum age (years): 12
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Accurate length determination of root canal is essential in root canal therapy. Radiography has been the conventional method for this measurement but recently several in-vitro studies have shown that new generations of Electronic Apex locators are as accurate as radiography in length determination. It is hypothesized that the latest generation of Electronic Apex locator can produce acceptable results as radiography when used for length determination.


Eligibility criteria: Inclusion Criteria:

* All the patients who are referred for Root Canal Therapy

Exclusion Criteria:

* Blocked Canals
* Open Apexes

Primary outcomes:
measure: adequacy of final working length
timeFrame: at the end of cleaning and shaping
Secondary outcomes:
Other outcomes:
Locations:
city: Shiraz
country: Iran, Islamic Republic of
facility: Shiraz University of Medical Sciences - Dental School
state: Fars
Study officials:
References:
Clinical trial NCT04835610: Effectiveness of Finger and Forehead Plethysmographic Variability Index Monitoring in Pediatric Patients
Official title: The Comparison of the Effectiveness of Finger and Forehead Plethysmographic Variability Index Monitoring in Pediatric Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: PVI
Lead sponsor: Marmara University
Sponsor class: OTHER
First posted: 2021-04-08
Enrollment: 2
Sex: ALL
Minimum age (years): 5
Maximum age (years): 12
Standard ages: CHILD
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: pediatric patients

Brief summary: In pediatric surgical patients, the sensitivity of forehead and finger PVI monitoring was similar for the prediction of fluid responsiveness, whereas the specificity of forehead monitoring was higher. The use of forehead PVI probes in the fluid management of these patients seemed to be appropriate because cephalic region was not affected by low perfusion states.

Detailed description: he Plethysmographic Variability Index (PVI) can be measured with both finger and forehead probes. Vasoconstriction may reduce the reliability of PVI measurements in pediatric surgical patients prone to hypothermia. The vascular structure of the forehead area is resistant to changes in vasomotor tonus. The aim of our study is to compare the efficacy of PVI values measured at the finger and forehead areas to predict fluid responsiveness in these patients.

Fifty pediatric patients with obtained parental consent and ethics committee approval underwent elective minor surgery were included into the study. Basic monitoring, finger and forehead perfusion index (PI) and PVI monitoring were applied. Hemodynamic parameters, PI, PVI, cardiac output (CO) values were recorded. The 15% increase in CO with passive leg raise (PLR) maneuver was estimated as fluid responsiveness. Two groups were created: Group R (fluid responsive); Group NR (fluid nonresponsive). Mann-Whitney U, t, chi-square and ROC tests were used in statistical evaluation.

Eligibility criteria: Inclusion Criteria:

written consent from their parents patients undergoing elective minor surgery with bleeding less than 500ml Children between the ages of 5-12.

Exclusion Criteria:

those who stay in the specified age range those with cardiopulmonary disease spontaneous breathing positive allen test peripheral circulatory failure vasopressor therapy anemia hypothermic

Primary outcomes:
measure: The Plethysmographic Variability Index (PVI)
timeFrame: 15 minute intervals during surgery
Secondary outcomes:
measure: Cardiac output (CO)
timeFrame: 15 minute intervals during surgery
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Marmara University
state: Maltepe
Study officials:
affiliation: Marmara University
name: MELIHA ORHON ERGUN
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04184310: Modified Perineal Linear Stapler Resection for External Rectal Prolapse: a Novel Approach
Official title: Modified Perineal Linear Stapler Resection for External Rectal Prolapse: a Novel Approach
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Rectal Prolapse
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
First posted: 2019-12-03
Enrollment: 36
Sex: ALL
Minimum age (years): 48
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: from December 2016 to July 2019, 36 elderly co-morbid patients with rectal prolapse were involved in this study which is performed in the GIT surgery unit of Zagazig University Hospital. the investigators used a modified linear stapler resection technique for the rectal prolapse. Postoperative follow up was done for one year to evaluate functional outcome, operative time, hospital stay and complications

Detailed description: The study was done in the GIT Unit of the General Surgery Department of Zagazig University Hospital in the period from December 2016 to July 2019. The hospital Institutional Review Board approved the study protocol. Thirty-six old, co-morbid and short life expectancy patients were included in the sample. They were evaluated for PSP. Informed consent was signed by all patients or first-degree relatives after full discussion of the advantage and disadvantage of the operation. Preoperative bimanual examination was done for rectal prolapse to rule out enterocele or cystocele and this was confirmed by MRI. The routine preoperative evaluation was done for all patients (physical examination, complete blood tests, ECG and chest x-ray). Bowel preparation was done for all patients.

Regarding bowel function, all patients were evaluated for fecal incontinence by Wexner score and for constipation by Rome II criteria. Prophylactic intravenous cephalosporin and metronidazole was given one hour before operation. The operation was done under spinal anesthesia in the lithotomy position with slight Trendeleburg to prevent trapping of abdominal organs between walls of rectum. All operations were done by the same surgical members of the unit. Hospital stay, Intraoperative and postoperative complications were recorded. All patients started oral fluids in the second day. Follow up was done for patients every 1,3,6,9 and 12 months in the outpatient clinic.

Eligibility criteria: Inclusion Criteria:

* old age
* complete rectal prolapse
* co-morbid ASA I to III

Exclusion Criteria:

-

Primary outcomes:
measure: treatment of rectal prolapse
timeFrame: 30 dyas
Secondary outcomes:
measure: post operative complications
timeFrame: one year
Other outcomes:
Locations:
city: Zagazig
country: Egypt
facility: Zagazig Unversity
Study officials:
affiliation: assistant professor
name: osama khalil, Ph.d
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01827410: High Agreement Between the Danish Ventral Hernia Database and Hospital Files in Region Zealand
Official title: High Agreement Between the Danish Ventral Hernia Database and Hospital Files in Region Zealand
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Data Agreement Between a Database and Hospital Files After a Ventral Hernia Repair
Lead sponsor: Zealand University Hospital
Sponsor class: OTHER
First posted: 2013-04-09
Enrollment: 408
Sex: ALL
Minimum age (years): 18
Maximum age (years): 120
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hernia repairs performed in Region Zealand and registered in the Danish Ventral Hernia Database during the study period

Brief summary: Is there agreement between data in the Danish Ventral Hernia Database and patient files


Eligibility criteria: Inclusion Criteria:

* All ventral hernia repairs

Primary outcomes:
measure: Data agreement
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Køge
country: Denmark
facility: Dept. of Surgery, Køge Hospital
Study officials:
affiliation: Dept. Surgery, Køge Hospital, University of Copenhagen
name: Frederik Helgstrand, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03553810: Role of ARNi in Ventricular Remodeling in Hypertensive LVH
Official title: Role of ARNi in Ventricular Remodeling in Hypertensive LVH
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Hypertensive Heart Disease
Lead sponsor: National Heart Centre Singapore
Sponsor class: OTHER
Collaborators: name: National Medical Research Council (NMRC), Singapore
First posted: 2018-06-12
Enrollment: 80
Sex: ALL
Minimum age (years): 21
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In Singapore, hypertension is very common in the adult population. Hypertensive heart disease is a leading cause of heart failure and cardiovascular death. Current management relies primarily on achieving blood pressure targets. However, the optimal blood pressure goals are controversial and there are inherent difficulties in measuring blood pressure using external devices applied to peripheral arteries. As a result of (usually longstanding) hypertension, the heart thickens (i.e. hypertrophies) to maintain function. Ultimately, HF may occur due to long standing energy deficits, muscle injury/death and diffuse interstitial fibrosis (heart muscle scarring). In an ongoing study (REMODEL, ClinicalTrial.gov Identifier NCT02670031), we have been able to undertake preliminary analyses with respect to factors associated with the development of fibrosis. In this randomize controlled trial, we will be examining a novel therapy that has the potential to induce regression cardiac hypertrophy and fibrosis.


Eligibility criteria: Inclusion Criteria:

* Increased left ventricular mass on cardiovascular magnetic resonance (based on established local age- and sex-specific CMR ranges)
* Essential hypertension

Exclusion Criteria:

* Known secondary causes of hypertension
* Previous intolerance to angiotensin receptor blockers
* History of heart failure
* Stage IV/V chronic renal disease (eGFR \< 30ml/min/1.73m2)
* Patients with serum potassium \> 5.2 mmol/L (mEg/L) at Visit 1
* History of cardiovascular events (myocardial infarction, strokes and transient ischemic attacks)
* Known atrial fibrillation
* Being unable to understand or comply with study procedures (including CMR)
* History or presence of any other disease with a life expectancy of \< 3 years
* Pregnant or nursing (lactating) women

Primary outcomes:
measure: Fibrosis volume
timeFrame: 52 weeks
Secondary outcomes:
measure: Left ventricular mass measured on CMR
timeFrame: 52 weeks
measure: Biomarker/biochemistry
timeFrame: 52 weeks
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: National Heart Centre Singapore
Study officials:
References:
Clinical trial NCT05471310: Videoocular Assessment of Eye Movement Activity in an Ataxia Telangiectasia
Official title: Eye-tacking Method as a Diagnostic Tool for Assessment of Oculomotor Parameters (Gaze-holding Score, Scan Path, Visually Guided Saccades Etc) in Pediatric Patients With Ataxia Telangiectasia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ataxia Telangiectasia
Dysmetria
Keywords: Eye movements
Saccades
Unstable gaze holding
Rehabilitation
Lead sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Sponsor class: OTHER
First posted: 2022-07-22
Enrollment: 5
Sex: ALL
Minimum age (years): 8
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The young citizens of Russia suffered from ataxia telangiectasia.

Brief summary: Ataxia-telangiectasia (A-T) is a multisystem auto-somal recessive disorder linked to the A-T mutated gene (ATM) on chromosome 11q22-23, and characterized by progressive neural degeneration, immunodeficiency, and progressive ocular motor dysfunction. In previous studies, the quantitative description of the ocular motor deficits from clinical examination was limited to various defects in saccade and gaze control, dysmetric saccades, impairments of smooth pursuit, gaze holding, convergence, vestibular and optokinetic nystagmus slow phases, and cancellation of the vestibulo-ocular reflex. The aim of our research is to add existing findings with quantitative description of oculomotor patterns in A-T patients using videooculography (VOG).


Eligibility criteria: Inclusion Criteria:

* confirmed diagnosis of ataxia telangiectasia,
* informed consent,
* stay at the Clinical Research Rehabilitation Center "Russkoe Pole" for 14 days.

Exclusion Criteria:

* epilepsy,
* poor visual acuity, inability to percept from a computer monitor,
* inability to hold head and posture satisfactory to perform the tasks,
* difficulty to obtain adequate recordings due to corrective lenses,
* visual field defects.

Primary outcomes:
measure: Gaze holding task
timeFrame: baseline, during the intervention-rehabilitation course (once)
measure: Visual search task
timeFrame: baseline, during the intervention-rehabilitation course (once)
measure: Visually guided saccade task
timeFrame: baseline, during the intervention-rehabilitation course (once)
Secondary outcomes:
measure: Scale for the assessment and rating of ataxia
timeFrame: baseline, during the intervention-rehabilitation course (once)
Other outcomes:
Locations:
city: Chéjov
country: Russian Federation
facility: Clinical Rehabilitation Research Center "Russkoe pole"
Study officials:
affiliation: Clinical Rehabilitation Research Center "Russkoe pole"
name: Alexander F. Karelin, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06577610: The Impact of a Colonoscopy Monitoring Program on Endoscopists' Performance
Official title: The Impact of a Colonoscopy Monitoring Program on Endoscopists' Performance
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Adenoma Colon Polyp
Sessile Serrated Adenoma
Keywords: adenoma
Sessile Serrated Adenoma
colonoscopy
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2024-08-29
Enrollment: 16
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: The goal of this clinical trial is to learn if colonoscopy monitoring program works to adenoma detection rate in endoscopists. It will also learn about the impact on sessile serrated lesion detection rate, adenomas per colonoscopy, sessile serrated lesions per colonoscopy, advanced adenoma detection rate. The main questions it aims to answer are:

Does colonoscopy monitoring program effect on adenoma detection rate in endoscopists?

Participants will:

Receive result of colonoscopy monitoring program or not every 3 months for 1 year


Eligibility criteria: Inclusion Criteria:

* Endoscopists with at least 1 year of colonoscopy experience

Exclusion Criteria:

* Endoscopists with less than 1 year of colonoscopy experience

Primary outcomes:
measure: adenoma detection rate
timeFrame: 1 year
Secondary outcomes:
measure: sessile serrated lesion detection rate
timeFrame: 1 year
measure: adenomas per colonoscopy
timeFrame: 1 year
measure: sessile serrated lesions per colonoscopy
timeFrame: 1 year
measure: advanced adenoma detection rate
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00855010: Pioglitazone on Pancreatic Steatosis and Bone Health
Official title: Effect of Pioglitazone on Pancreatic Steatosis and Bone Health
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Type 2 Diabetes
Keywords: Pioglitazone
prediabetes
diabetes
obesity
Pancreatic fat
Lead sponsor: University of Texas Southwestern Medical Center
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2009-03-03
Enrollment: 42
Sex: ALL
Minimum age (years): 21
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Randomized, double blind, placebo controlled trial evaluating the effect of pioglitazone on pancreatic fat content and bone turnover markers.


Eligibility criteria: Inclusion Criteria:

* Fat level in the pancreas above 4% (measurement done by us with an MRI)
* English speaker
* over 21 years old

Exclusion Criteria:

* contraindication to MRI
* anemia
* pregnancy or desire to conceive
* use of unapproved medications
* prior pancreatic disease
* use of more then 2 alcoholic drinks every day

Primary outcomes:
measure: Pancreatic Fat Content
timeFrame: 12 months
measure: Bone Turnover Marker - Intact Parathyroid Hormone (PTH)
timeFrame: 12 months
measure: Bone Turnover Marker - Plasma 25-hydroxyvitamin D
timeFrame: 12 months
Secondary outcomes:
measure: Beta-cell Function
timeFrame: 12 months
measure: Hepatic Fat Content
timeFrame: 12 months
measure: Subcutaneous Fat Area
timeFrame: 12 months
measure: Visceral Fat Area
timeFrame: 12 months
measure: Bone Mineral Density
timeFrame: 12 months
measure: Disposition Index
timeFrame: 12 months
Other outcomes:
Locations:
city: Dallas
country: United States
facility: UT Southwestern Medical Center
state: Texas
Study officials:
References:
Clinical trial NCT00632710: Assessment of the Effectiveness of Low-Level Laser Therapy on the Hands of Patients With Rheumatoid Arthritis
Official title: Assessment of the Effectiveness of Low-Level Laser Therapy on the Hands of Patients With Rheumatoid Arthritis: a Randomized Double-Blind Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Rheumatoid Arthritis
Keywords: rheumatoid arthritis
hands
randomized controlled
low level laser
Lead sponsor: Federal University of São Paulo
Sponsor class: OTHER
First posted: 2008-03-11
Enrollment: 82
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the present study was to assess the effectiveness of low-level laser therapy on the reduction in pain and improvement in function in the hands of patients with rheumatoid arthritis

Detailed description: Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology that basically compromises the joints in a generalized, symmetrical, additive and usually progressive manner. This clinical condition includes pain and altered functionality. Low-level laser therapy (LLLT) has been studied since the 1970s with regard to its therapeutic effects. The literature suggests that it offers analgesic as well as anti-inflammatory benefits.

A number of studies carried out in the laboratory and on animals have shown that LLLT contributes toward the treatment of inflammatory joint disease. However, studies on humans with RA have yielded controversial results. A large part of the authors researched state that further randomized double-blind controlled studies should be carried out to prove the effectiveness of LLLT on RA. Thus, the aim of the present study was to assess the effectiveness of LLLT on the reduction in pain and improvement in function in the hands of patients with RA.

Eligibility criteria: Inclusion Criteria:

* patients with RA
* inflammatory condition of at least two hand joints among the wrists, proximal interphalangeal (PIP) joint and metacarpophalangeal (MCP) joint
* visual analogue scale (VAS) for pain between 3 and 8 cm during activities of daily living
* and being of either gender

Exclusion Criteria:

* skin lesions at the application site
* other illnesses affecting the hands; physiotherapy for the hands in the previous three months
* joint injections in the previous three months
* change in disease-modifying anti-rheumatic drugs in the previous three months
* and change in corticosteroids in the previous month.

Primary outcomes:
measure: pain
timeFrame: 2 months
Secondary outcomes:
measure: function
timeFrame: 2 months
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Federal University of Sao Paulo
state: SP
Study officials:
affiliation: Federal University of São Paulo
name: Sandra M Meireles, Physiother.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03959410: Impact of HPV on a Cohort of Southern Italian Women: Epidemiological, Clinical, Morphological and Microbiological Features
Official title: Impact of HPV on a Cohort of Southern Italian Women: a Prospective Observational Study About Epidemiological, Clinical, Morphological and Microbiological Features of HPV Infection
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cervix Cancer
Keywords: hpv
cervical cancer
microbiome
Lead sponsor: University of Campania Luigi Vanvitelli
Sponsor class: OTHER
First posted: 2019-05-22
Enrollment: 150
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: HPV is known to be the causal agent in the majority of cervical cancers. However, the role of the cervical bacterial microbiome in cervical cancer is not clear


Eligibility criteria: Inclusion Criteria:

* Women in fertile age

Exclusion Criteria:

* severe comorbidities

Primary outcomes:
measure: Evaluation of Cervical microbiome
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Napoli
country: Italy
facility: Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli"
Study officials:
References: