Clinical trial NCT00591708: Calcium Metabolism in Asian Adolescents
Official title: Calcium Metabolism in Asian Adolescents
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bone Mineralization
Adolescent Development
Keywords: calcium
bone
bone density
adolescence
Lead sponsor: Purdue University
Sponsor class: OTHER
Collaborators: name: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
First posted: 2008-01-11
Enrollment: 34
Sex: ALL
Minimum age (years): 11
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: Maximizing calcium retention by the skeleton within the genetic potential is a key strategy to prevent osteoporosis. It has been shown that calcium retention varies between blacks and whites and between gender within race. This study is designed to study the relationship between calcium intakes and calcium retention in Asian adolescent girls and boys. It is hypothesized that calcium intakes which maximize calcium retention will be lower in Asians than for whites studies under the same conditions. In addition it is thought that the differences between races in the physiological mechanisms involved in calcium metabolism will result in a lower calcium intake required to observe a plateau in calcium retention. This is turn could be translated into lower calcium requirements in Asians relative to Caucasians for achieving optimal peak bone mass.

Detailed description: Adolescent Asian boys and girls will consume a controlled diet for two three-week periods. The basal diet will contain 600 mg/d calcium and will be supplemented with beverages fortified with calcium citrate malate to achieve a range of intakes from 600-2100 mg Ca/d. Each participant will be studied on one of four combinations of a lower and a higher calcium intake within that range in a cross-over design.

Eligibility criteria: Inclusion Criteria:

* healthy teens of Asian descent

Exclusion Criteria:

* malabsorptive disorders
* anemia
* smoking, illegal drugs
* oral contraceptives
* pregnancy
* drugs that influence calcium metabolism
* body weight for height greater than 85 percentile

Primary outcomes:
measure: Calcium retention (mg/d)
timeFrame: Metabolic balance will be determined over a two week period on a controlled diet after equilibration for one week on the same diet.
Secondary outcomes:
measure: Serial serum biochemistry profiles (PTH, 1,25 dihydroxy-vitamin D, calcium)
timeFrame: Six serial measurements in 10 hours after ingestion of a calcium load representing one third of the daily consumption
Other outcomes:
Locations:
city: West Lafayette
country: United States
facility: Department of Foods and Nutrition, Purdue University
state: Indiana
Study officials:
affiliation: Department of Foods and Nutrition, Purdue University
name: Connie Weaver, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Department of Foods and Nutrition, Purdue University
name: Berdine R Martin, PhD
role: STUDY_DIRECTOR
References:
citation: Wu L, Martin BR, Braun MM, Wastney ME, McCabe GP, McCabe LD, DiMeglio LA, Peacock M, Weaver CM. Calcium requirements and metabolism in Chinese-American boys and girls. J Bone Miner Res. 2010 Aug;25(8):1842-9. doi: 10.1002/jbmr.76.