Clinical trial NCT03231072: Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT
Official title: Effects of the Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by Electrical Impedance Tomography and End-Expiratory Lung Volume
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pleural Effusion
Drainage
Electric Impedance Tomography
Keywords: mechanical ventilation
pleural effusion
EIT
Lead sponsor: Czech Technical University in Prague
Sponsor class: OTHER
Collaborators: name: Military University Hospital, Prague
First posted: 2017-07-27
Enrollment: 19
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Evacuation of pleural effusion (PE) represents a disputable therapy in mechanically ventilated patients. Patients on mechanical ventilation indicated by the physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured in order to describe impact of PE evacuation on aeration and ventilation of the lungs.

Detailed description: Critically ill patients treated in intensive care units have a disorder of distribution and volume of body fluids due to principal illness and some therapeutic interventions. One of its manifestations is pleural effusion (PE) formation.

Patients on mechanical ventilation indicated by treating physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured. The purpose of the study is to better understand impact of PE evacuation on aeration and ventilation of the lungs.

Eligibility criteria: Inclusion Criteria:

* mechanical ventilation, presence of pleural effusion, decision of the treating physician to drain it

Exclusion Criteria:

* impossibility to apply EIT belt or to find suitable save point for drainage when the EIT belt is attached
* standard EIT exclusion criteria according to the device manufacturer

Primary outcomes:
measure: Change of the thorax electrical impedance following pleural effusion drainage in mechanically ventilated patients
timeFrame: 4 hours
Secondary outcomes:
measure: Change of the distribution of ventilation following pleural effusion drainage in mechanically ventilated patients
timeFrame: 4 hours
Other outcomes:
Locations:
city: Prague
country: Czechia
facility: The Military University Hospital
Study officials:
affiliation: Czech Technical University in Prague
name: Karel Roubik, Prof., PhD.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Razazi K, Thille AW, Carteaux G, Beji O, Brun-Buisson C, Brochard L, Mekontso Dessap A. Effects of pleural effusion drainage on oxygenation, respiratory mechanics, and hemodynamics in mechanically ventilated patients. Ann Am Thorac Soc. 2014 Sep;11(7):1018-24. doi: 10.1513/AnnalsATS.201404-152OC.
citation: Mattison LE, Coppage L, Alderman DF, Herlong JO, Sahn SA. Pleural effusions in the medical ICU: prevalence, causes, and clinical implications. Chest. 1997 Apr;111(4):1018-23. doi: 10.1378/chest.111.4.1018.
citation: Goligher EC, Leis JA, Fowler RA, Pinto R, Adhikari NK, Ferguson ND. Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care. 2011;15(1):R46. doi: 10.1186/cc10009. Epub 2011 Feb 2.
citation: Alves SH, Amato MB, Terra RM, Vargas FS, Caruso P. Lung reaeration and reventilation after aspiration of pleural effusions. A study using electrical impedance tomography. Ann Am Thorac Soc. 2014 Feb;11(2):186-91. doi: 10.1513/AnnalsATS.201306-142OC.