louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01131455: ACP for Local Application in Ankle Arthrodesis
Official title: Autologous Concentrated Platelet-rich Plasma (Arthrex ACP®) for Local Application in Ankle Arthrodesis: A Prospective Outcome Analysis.
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Ankle Arthritis
Lead sponsor: Columbia Orthopaedic Group, LLP
Sponsor class: OTHER
First posted: 2010-05-27
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the outcomes of patients who undergo three different types of surgeries for ankle fusion and reconstruction.

Detailed description: It is understood that an elevated concentration of platelets in the mix of the arthrodesis construct applied intra-operatively to the bony surface, has osteo-generating and enhanced wound healing properties. With that knowledge there is a clinical need and enthusiasm for the application of concentrated platelets, which release a large quantity of growth factors to encourage recovery in non healing injuries or surgical sites. This study represents an effort to more clearly define the true clinical outcomes with or without biologic enhancement, and fulfills a need for fortifying evidence concerning the efficacy of ACP in live human bone healing-- based on radiographic and CT scans.

Eligibility criteria: Inclusion Criteria:

* patients whom present the need for the elective surgery

Exclusion Criteria:

* None

Primary outcomes:
measure: CT Scan for Fusion Analysis
timeFrame: 8 weeks post op.
Secondary outcomes:
Other outcomes:
Locations:
city: Columbia
country: United States
facility: Columbia Orthopedic Group
state: Missouri
Study officials:
affiliation: Columbia Orthopaedic Group
name: Paul Shurnas
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03965455: Clinical Efficacy of Conventional and Diode Laser-Assisted Frenectomy in Patients With Abnormal Different Frenum Insertions: A Retrospective Study
Official title: Clinical Efficacy of Conventional and Diode Laser-Assisted Frenectomy in Patients With Abnormal Different Frenum Insertions: A Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Frenulum; Elongation
Keywords: labial frenum
laser therapy
recurrence
oral hyigiene
Lead sponsor: Marmara University
Sponsor class: OTHER
First posted: 2019-05-29
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study utilized treatment records of patients treated with maxillary labial frenectomy in the Clinics of Periodontology, Faculty of Dentistry, Marmara University.

Brief summary: Aim: The aim of this retrospective study was to assess the frenum attachment recurrence and evaluate clinical parameters after conventional and diode laser-assisted frenectomy in patients with different abnormal frenum insertions.

Methods: Data records of 429 patients treated with maxillary labial frenectomy between January 1, 2016 and January 1, 2018 were screened. Records of 70 patients meeting the inclusion criteria were evaluated. Data were analyzed in terms of gender, age, category of frenum, presence of diastema, operation technique, type of periodontal disease. The distance between frenum attachment and mucogingival junction (FMGJ), plaque index (PI), gingival index (GI) and probing depth were assessed.


Eligibility criteria: Inclusion Criteria:

(a) systemically healthy, (b) nonsmoker, (c) aged between 18 and 65 years, (d) received initial periodontal treatment before frenectomy, (e) presence of central and lateral incisors and canines at maxilla, (f) not received any kind of periodontal surgery, prosthodontic and restorative treatment which may affect the anatomy of the relevant region.

Exclusion Criteria:

Subjects with incomplete documentation and without at least 6-week follow-up observation were excluded.

Primary outcomes:
measure: recurrence
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Marmara University
state: Maltepe
Study officials:
References:
Clinical trial NCT04424355: Magnetic Resonance Imaging to Detect Signs of Viral Pneumonia in Patients With Coronavirus Infection.
Official title: Possibilities of Chest Magnetic Resonance Imaging (MRI) in Diagnostics of COVID-19. The Use of MRI to Assess Lung Damage in Patients With Coronavirus Infection
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronavirus Infections
Pneumonia
Keywords: Computed tomography
Magnetic resonance imaging
Lung MRI
Lead sponsor: Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Sponsor class: OTHER
First posted: 2020-06-09
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients with suspected viral COVID-19 pneumonia will be included in the study

Brief summary: Since the onset of the COVID-19 pandemic, the importance of chest computed tomography (CT) in detecting signs of viral pneumonia has become clear from the literature. However, the increased patient flow creates an additional pressure on CT centers. We believe, the use of chest magnetic resonance imaging (MRI) can help to test patients for CОVID-19 when CT scan is not available. Lung MRI may be useful in routing a patient in a difficult epidemiological situation.

Detailed description: Currently, with increased load of CT studies, alternative methods of viral pneumonia signs' visualization are required.

Investigators hypothesize that chest MRI could be a test for detecting pulmonary features of COVID-19. They consider using MRI to assess COVID-19 viral pneumonia. Absence of radiation exposure to patients is a clear advantage of MRI.

This is a prospective, observational cohort study assessing patients with suspected COVID-19. It's primary goal is to determine the ability of multiparametric MRI to detect lung abnormalities - ground-glass opacity (GGO), consolidation, "crazy paving" pattern, pleuritis - in comparison to CT scan. In this study each patient with suspected pneumonia will sequentially undergo both chest CT and MRI during his/her visit. Scan protocols will be identical for each patient. Each participants completed an online questionnaire.

Eligibility criteria: Inclusion Criteria:

* A referral from the attending physician for a chest CT scan
* Suspected pneumonia
* Signed informed consent
* Over 18 years old

Exclusion Criteria:

* Pregnant or nursing women
* Presence of foreign implanted objects in the body at the scan level (including cardiac pacemakers, spine metalware)

Primary outcomes:
measure: Number of zones of pulmonary parenchyma corresponding to viral pneumonia detected by chest MRI in comparison with CT scan
timeFrame: Upon completion, up to 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Moscow
country: Russian Federation
facility: Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Study officials:
References:
Clinical trial NCT00692055: Study Evaluating the Bioavailability of Naproxen 375 mg in Two Formulations
Official title: Study Evaluating the Bioavailability of Naproxen 375 mg in Two Formulations
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Arthritis
Lead sponsor: POZEN
Sponsor class: INDUSTRY
First posted: 2008-06-06
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: We will evaluate the bioavailability of naproxen 375 mg in two formulations


Eligibility criteria: Inclusion Criteria:

* Healthy male or non-pregnant female subjects between 18-55 years as well as other standard inclusion criteria for a study of this nature

Exclusion Criteria:

* Standard exclusion criteria for a study of this nature

Primary outcomes:
measure: To assess and compare the pharmacokinetics bioavailability of a single oral dose of naproxen administered in two formulations
timeFrame: 72-hour PK
Secondary outcomes:
measure: To evaluate the safety of the two treatments
timeFrame: entire study duration
Other outcomes:
Locations:
city: Austin
country: United States
state: Texas
Study officials:
References:
Clinical trial NCT02870855: Effect of Intrauterine Injection of HCG on Pregnancy Outcome in Repeated Implantation Failure Patients
Official title: Effect of Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer on Clinical Pregnancy Outcome in Repeated Implantation Failure Patients
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Infertility
Lead sponsor: Reproductive & Genetic Hospital of CITIC-Xiangya
Sponsor class: OTHER
First posted: 2016-08-17
Enrollment: 0
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Repeated implantation failure（RIF） is a insurmountable bottleneck in assisted reproductive technology, many studies have considered that the cause of two-thirds of implant failure is the decreased endometrial receptivity. Human chorionic gonadotropin (hCG) is an early pre-plant signal molecule secreted by the embryo, it can promote endometrial proliferation, increase blood flow and promote embryonic adhesion and inhibit self-regulate apoptosis of trophoblast cells. Previous studies showed that: intrauterine injection of HCG before embryo transfer can improve clinical outcomes in IVF/Intracytoplasmic sperm injection(ICSI). But some studies found that the intrauterine injection of HCG can not significantly improve the success rate of blastocyst transfer, and the reason may be the intrauterine injection of HCG time is too late to significantly increase the implantation rate. Would ahead of intrauterine injection of HCG be more effective? Thus, the patients of repeated implantation frozen embryo cycle according to the random principle accepted two kinds of transplants ways: ①intrauterine injection of HCG before blastocyst transfer; ②blastocyst transfer. Try to understand whether intrauterine injection of HCG can significantly improve the clinical pregnancy rate of blastocyst transfer in repeated implantation failure patients.


Eligibility criteria: Inclusion Criteria:

* women with unexplained RIF(two to four previous embryo transfers without achieving pregnancy);
* age\<36 years;
* frozen embryo transfer cycles

Exclusion Criteria:

* polycystic ovary syndrome
* uterine abnormalities (double uterus, bicornuate uterus, unicornuate uterus and uterine mediastinum)
* intrauterine adhesions
* endometriosis
* adenomyosis
* hydrosalpinx
* uterine fibroids (submucosal fibroids, non-mucosal fibroids \> 4 cm and / or endometrial pressure)
* thydroid dysfunction and hyperprolactinemia

Primary outcomes:
measure: clinical pregnancy rate
timeFrame: Until 28 day after embryo transferred
Secondary outcomes:
measure: spontaneous abortion rate
timeFrame: until 28 day after embryo transferred
measure: ectopic pregnancy rate
timeFrame: until 28 day after embryo transferred
Other outcomes:
Locations:
city: Changsha
country: China
facility: Reproductive & Genetic Hospital of CITIC-XIANGYA
state: Hunan
Study officials:
References:
Clinical trial NCT06462755: Perioperative Database of Chinese Elderly Patients for Postoperative Acute Kidney Injury
Official title: Perioperative Database of Chinese Elderly Patients for Postoperative Acute Kidney Injury
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Acute Kidney Injury
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
First posted: 2024-06-17
Enrollment: 57089
Sex: ALL
Minimum age (years): 65
Maximum age (years): 120
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Elderly patients (aged ≥ 65 years) undergoing non-cardiac surgeries

Brief summary: To develop and externally validate a risk prediction model for postoperative acute kidney injury (PO-AKI) in elderly patients undergoing major noncardiac surgery, addressing the current gap in predictive tools for this vulnerable population.

The endpoint was the occurrence of PO-AKI within seven days following surgery. Diagnoses were based on the Kidney Disease: Improving Global Outcomes (KDIGO) criterion. Potential PO-AKI-related perioperative data were retrieved and extracted from electronic medical record for model derivation and validation.

Clinicians may consider implementing this externally validated risk prediction model to stratify elderly patients' PO-AKI risks in the early postoperative phases of noncardiac surgery in elderly patients.


Eligibility criteria: Inclusion Criteria:

* elderly patients (aged ≥ 65 years) undergoing non-cardiac surgeries

Exclusion Criteria:

* (1) Patients who underwent endoscopic or transplant procedures;
* (2) Patients who underwent surgeries lasting longer than 10 hours;
* (3) Patients who had severe preoperative kidney dysfunction, defined as preoperative sCr levels ≥ 353.6 μmol/L, or a baseline estimated Glomerular Filtration Rate (eGFR) \< 15 ml/min per 1.73 m2;
* (4) Patients without sCr values at baseline or during follow-up to detect PO-AKI occurrences.

Primary outcomes:
measure: Number of participants with postoperative acute kidney injury
timeFrame: within seven days following surgery
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01176955: A Novel Method to Improve Acne Outcomes
Official title: A Novel Method for Improving Acne Outcomes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acne Vulgaris
Keywords: Acne
Acne vulgaris
Adherence
Compliance
MEMS
Benzoyl peroxide
Lead sponsor: Wake Forest University Health Sciences
Sponsor class: OTHER
First posted: 2010-08-06
Enrollment: 20
Sex: ALL
Minimum age (years): 13
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is an investigator-blinded, prospective study of 20 subjects aged 13 through 18 with mild to moderate acne. Study subjects will be randomized to an internet survey group, in which an email link for a survey ascertaining the status of the subject's acne is sent weekly, or to a control group. All study subjects will use benzoyl peroxide 5% gel, and adherence and clinical improvement will be monitored over 12 weeks. The investigators hypothesis is that subjects in the internet survey group will have improved adherence to the study medication and clinical outcomes, because the weekly survey will remind subjects to use their medication.


Eligibility criteria: Inclusion Criteria:

* male or female 13 to 18 years of age with a diagnosis of mild to moderate acne vulgaris by a dermatologist.
* written consent of participation must be given by parent or guardian and child.

Exclusion Criteria:

* Age less than 13 or greater than 18 years of age.
* Known allergy or sensitivity to topical benzoyl peroxide gel in the subject.
* Inability to complete all study-related visits.
* Introduction of any other prescription medication, topical or systemic, for acne vulgaris while participating in the study.
* Subjects may not use topical retinoids or other benzoyl peroxide products, including Proactiv® or topical prescription medications while enrolled in the study.
* Women that are actively trying to become pregnant or wish to become pregnant during the time frame the study is to take place will be excluded.
* Subjects will be carefully selected for this study and only those deemed appropriate for treatment with benzoyl peroxide will be placed on this medication.

Primary outcomes:
measure: The Measured Adherence by the MEMS Cap in Relation to the Patient Reported Adherence Via the Internet Survey.
timeFrame: 12 weeks
Secondary outcomes:
measure: The Change (Dynamic Assessment) in the Acne Global Assessment From Baseline to End of Study.
timeFrame: Baseline to 12 weeks
measure: The Change (Dynamic Assessment) From Baseline to End of Treatment in Lesion Counts.
timeFrame: Baseline to 12 weeks
measure: The Measured Adherence by the MEMS Cap in Relation to the Change (Dynamic Assessment) in the Acne Global Assessment.
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Winston-Salem
country: United States
facility: Wake Forest University Health Sciences, Department of Dermatology
state: North Carolina
Study officials:
affiliation: Wake Forest University
name: Steven R Feldman, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00534755: Prospective & Retrospective Data Collection of Breast Cancer Cases From 2000 to Present
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Breast Cancer
Lead sponsor: King Faisal Specialist Hospital & Research Center
Sponsor class: OTHER
First posted: 2007-09-26
Enrollment: 10000
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP

Brief summary: Prospective \& Retrospective data collection of breast cancer cases from 2000 to present


Eligibility criteria: Inclusion Criteria:

* Patients with breast cancer

Primary outcomes:
measure: Database
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Riyadh
country: Saudi Arabia
facility: KFSH&RC
Study officials:
affiliation: KFSH&RC
name: Dahish Ajarim, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03836755: Evaluation of the Stability of Osseointegrated Implant in Amputees
Official title: Evaluation of the Stability of Osseointegrated Implant in Upper Limb or Lower Limb Amputees
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prosthesis Migration
Amputation
Keywords: osseointegration
implant migration
amputee
Lead sponsor: Istituto Ortopedico Rizzoli
Sponsor class: OTHER
Collaborators: name: University of Bologna
name: Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro
name: Scuola Universitaria Superiore Sant'Anna Pisa
First posted: 2019-02-11
Enrollment: 4
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The study concerns the technique of osseointegration that consists of inserting a titanium pin into the bone of the amputated limb. A removable external prosthesis will then be connected to the implant section that protrudes from the soft parts.

The benefits of using an osseointegrated prosthesis are the improved sensory feedback (osseoperception) and absence of the socket. This leads to better anchoring of the prosthesis to the abutment, greater control of the prosthesis and the absence of heat, pain, and pressure sores.

The osseointegrated prosthesis does not reduce the mobility of the limb and promotes good growth of bone and muscle mass. The aim of this study is to evaluate the stability of the osseointegrated implant in trans-femoral and trans-humeral amputees.

The main outcome: quantitative evaluation (rotations, translation and MTPM) of the stability of the implant bone interface by Roentgen Stereo-photogrammetric Analysis (RSA) and follow-up.

The secondary outcome: evaluation of the quality of life improvement in patients through clinical score and satisfaction survey.


Eligibility criteria: Inclusion Criteria:

* BMI\<35 kg/m2
* Problem in using socket

Exclusion Criteria:

* Diabetes;
* Peripheral vascular diseases;
* Psychiatric problems;
* Pregnancy;
* Rheumatoid arthritis;
* Neurovascular diseases;
* Neurological deficits;
* Amputation of the contralateral limb;
* Infections in progress;
* Immunosuppression;

Primary outcomes:
measure: Rotation
timeFrame: 24 months
measure: Translation
timeFrame: 24 months
Secondary outcomes:
measure: Health-related quality of life
timeFrame: 24 months
measure: Pain evaluation
timeFrame: 24 months
measure: Lower limb: Autonomy
timeFrame: 24 months
measure: lower limb: Mobility
timeFrame: 4 months
measure: Upper limb: functionality
timeFrame: 24 months
measure: Upper Limb: Development and evaluation of the activities measure for upper limb amputees
timeFrame: 24 months
Other outcomes:
Locations:
city: Bologna
country: Italy
facility: Istituto Ortopedico Rizzoli
Study officials:
References:
Clinical trial NCT06192355: Single-use Versus Reusable Gastroscopes in Patients With Upper Gastrointestinal Bleeding.
Official title: One-Scope II: Single-use Versus Reusable Gastroscopes in Patients With Upper Gastrointestinal Bleeding.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Upper Gastrointestinal Bleeding
Keywords: Endoscopy
Emergency
Lead sponsor: University Hospital Augsburg
Sponsor class: OTHER
First posted: 2024-01-05
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Controlled-randomized trial evaluating single-use versus reusable gastroscopes in patients with upper gastrointestinal bleeding.

Detailed description: Acute upper gastrointestinal bleeding is a common medical emergency. According to guidelines, endoscopic evaluation should be performed within 24 hours. With an overall high incidence and an overall high number of diagnostic and therapeutic endoscopic procedures, the introduction of new endoscopic concepts may have a profound impact on outcomes as well as cost-effectiveness in upper gastrointestinal bleeding. For this purpose, the use of single-use gastroscopes represents an interesting possibility. Hygiene issues in the emergency situation are also relevant. The previous feasibility study One-Scope I demonstrated that the diagnosis as well as the therapy of upper gastrointestinal bleeding is possible with single-use gastroscopes. In this follow-up study, the investigators compare the use of single-use versus reusable gastroscopes in participants with suspected upper gastrointestinal bleeding in a randomized controlled trial.

Eligibility criteria: Inclusion Criteria:

* Glasgow-Blatchford score (GBS) \>2
* Clinical signs of upper bleeding

Exclusion Criteria:

* pregnancy
* Unable to provide consent

Primary outcomes:
measure: intraprocedural technical success
timeFrame: Up to 20 minutes
Secondary outcomes:
measure: intraprocedural clinical success
timeFrame: Up to 45 Minutes
measure: re-bleeding rate
timeFrame: Up to 30 days
measure: blood transfusions
timeFrame: Up to 30 days
measure: Length of Stay
timeFrame: Up to 30 days
measure: Length of intervention
timeFrame: Up to 60 minutes
measure: cross over to reusable gastroscope
timeFrame: Up to 60 Minutes
measure: Adverse events
timeFrame: Up to 30 days
Other outcomes:
Locations:
city: Augsburg
country: Germany
facility: University Hospital of Augsburg
state: Bavaria
Study officials:
affiliation: Unervsity Hospital Augsburg
name: Christoph Römmele, MD
role: PRINCIPAL_INVESTIGATOR
References: