Clinical trial NCT06466681: Changes in Attentional Control After a Focal Seizure.
Official title: Changes in Attentional Control After a Focal Seizure.
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Temporal Lobe Epilepsy
Frontal Lobe Epilepsy
Others Subtypes
Keywords: Attentional control
Focal epilepsy
Event related potentials
Functionnal connectivity
high-resolution EEG
Lead sponsor: University Hospital, Lille
Sponsor class: OTHER
First posted: 2024-06-20
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Administration of the subtest of divided attention of the Test of Attentional Performance (TAP), recording of the event related potentiels N200 and P300, measure of the variation of power in several frequency bands (theta, alpha and beta) and measure of the high-resolution EEG connectivity during an attentional task at several time-points : a first time during interictal period (no seizure for more than 24 hours) and 1, 3, 6 and 24 hours after a focal seizure.

Brief summary: Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.


Eligibility criteria: Inclusion Criteria:

* Age superior to 18 and under 80
* Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up
* Normal global cognitive performance (standard progressive Raven matrices score \> 5th percentile)
* Be affiliated to the social security system
* Have signed an informed consent

Exclusion Criteria:

* Pregnancy or breastfeeding
* Not able to give consent (Article 1121-8 of the CSP)
* Vulnerable person
* Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP)
* Guardianship
* Have a high probability of not respecting the protocol or of abandoning the study
* Absence of any epileptic seizure recorded during the hospitalization
* Recurrent seizures preventing the recording of at least 24 hours without any seizure following a seizure.

Primary outcomes:
measure: Subtest of divided attention of the Test of Attentional Performance (TAP)
timeFrame: 24 hours
Secondary outcomes:
measure: N200 amplitude and latency
timeFrame: 24 hours
measure: Strength of EEG functionnal connectivity during an attentional task (global and regional)
timeFrame: 24 hours
measure: Variation of power in several frequency bands (theta, alpha and beta) during an attentional task.
timeFrame: 24 hours
measure: Magnetic resonance imaging functional connectivity.
timeFrame: up to 5 days
measure: Differences in N200 and P300 amplitude and latency recorded between different subgroups according to the epileptic focus.
timeFrame: 24 hours
measure: P300 amplitude and latency
timeFrame: 24 hours
measure: Differences in strength of EEG functional connectivity during an attentional task recorded between different subgroups according to the epileptic focus.
timeFrame: 24 hours
measure: Differences in variation of power in several frequency bands (theta, alpha and beta) during an attentional task recorded between different subgroups according to the epileptic focus.
timeFrame: 24 hours
measure: Differences in magnetic resonance imaging functional connectivity recorded between different subgroups according to the epileptic focus.
timeFrame: 24 hours
Other outcomes:
Locations:
city: Lille
country: France
facility: University Hospital,
Study officials:
References: