Clinical trial NCT05568862: Ureteric Jet Doppler Waveforms in Patients With Spinal Cord Injury
Official title: The Characteristics of Ureteric Jet Doppler Waveforms and Factors Affecting Them in Patients With Spinal Cord Injury
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spinal Cord Injuries
Lead sponsor: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Sponsor class: OTHER
First posted: 2022-10-06
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Spinal cord injury patients who were hospitalized in the spinal cord injury Rehabilitation Unit of our rehabilitation center and 32 no spinal cord injury who presented at outpatient clinics.

Brief summary: Urinary dysfunction is very common in individuals with spinal cord injury. The urine flowing from the collecting ducts to the renal calyx stretches the calyces. ANS controlled peristaltic contractions originate in the proximal renal pelvis and travel down the ureters, pushing urine from the renal pelvis towards the bladder. The urine bolus delivered from the kidneys through the peristaltic contraction of the ureter creates an image called ureteric jet. Using the Doppler analysis of ureteral jets, previous studies have examined the changes in the ureteric jet pattern in pathological conditions such as the diagnosis of normal ureteral physiology.

Detailed description: This cross-sectional study was conducted at a tertiary rehabilitation center. Eighteen spinal cord injury patients who met the inclusion criteria and 24 healthy volunteers were included in the study. The appearance of üreteric jet form and bladder wall thicknesses were obtained by urinary Doppler ultrasound both in patient and control groups. Detrusor pressure and bladder volume were measured only in patient group during urodynamic assessment.

Eligibility criteria: The case group

Inclusion Criteria:

* With signs of upper motor neuron lesion,
* Suprasacral spinal cord injury,
* Normal urinary ultrasound findings
* Planned urodynamics

Exclusion Criteria:

* Neurological disease other than spinal cord injury
* Urinary tract infection
* Urinary obstruction
* History of urinary tract Stones
* Diabetes, hypertension
* History of urinary surgery,
* Sacral injury
* Second motor neuron lesions (such as cauda equina, or cauda conus)

The control group

Inclusion Criteria:

• Normal urinary ultrasonography

Exclusion Criteria:

* Neurological disease
* Urinary tract infection
* Urinary obstruction
* History of urinary tract Stones
* Diabetes, hypertension

Primary outcomes:
measure: doppler USG
timeFrame: 15-30 minute
measure: Urodynamic assessment.
timeFrame: 30 minute
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gaziler PMR, Training and Research Hospital, Department of PMR
state: Çankaya
Study officials:
affiliation: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
name: İlkay Karabay
role: PRINCIPAL_INVESTIGATOR
References: