Clinical trial NCT05376631: Effect of Fresh Gas Flow on Emergence Time
Official title: Effect of Fresh Gas Flow on Emergence Time in the Patients Undergoing Transurethral Resection of Bladder Tumor: A Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bladder Cancer
Lead sponsor: Asan Medical Center
Sponsor class: OTHER
First posted: 2022-05-17
Enrollment: 54
Sex: ALL
Minimum age (years): 20
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of this study is to evaluate the effect of fresh gas flow on emergence time in patients undergoing transurethral resection of bladder tumor.

Detailed description: The purpose of this study is to evaluate the effect of fresh gas flow (5 L/min vs. 10 L/min) on emergence time in patients undergoing transurethral resection of bladder tumor.

Eligibility criteria: Inclusion Criteria:

* Patients who are scheduled transurethral resection of bladder tumor under general anesthesia
* Patients aged between 20 and 79 years old
* American Society of Anesthesiologists physical status ≤2
* Patients who are voluntarily agreed to this clinical study

Exclusion Criteria:

* A long operation (2 hours or longer)
* Hearing disturbance
* Cognitive disorder
* Psychiatric substance abuse
* Patient's denial

Primary outcomes:
measure: Emergence time
timeFrame: From end of surgery to extubation (assessed up to 30 minutes after surgery)
Secondary outcomes:
measure: Time to spontaneous movement
timeFrame: From end of surgery to spontaneous movement (assessed up to 30 minutes after surgery)
measure: Time to eye opening
timeFrame: From end of surgery to eye opening (assessed up to 30 minutes after surgery)
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
Study officials:
affiliation: Asan Medical Center
name: Young-Kug Kim, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gaya da Costa M, Kalmar AF, Struys MMRF. Inhaled Anesthetics: Environmental Role, Occupational Risk, and Clinical Use. J Clin Med. 2021 Mar 22;10(6):1306. doi: 10.3390/jcm10061306.
citation: Brioni JD, Varughese S, Ahmed R, Bein B. A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics. J Anesth. 2017 Oct;31(5):764-778. doi: 10.1007/s00540-017-2375-6. Epub 2017 Jun 5.
citation: Baum JA. Low-flow anesthesia: theory, practice, technical preconditions, advantages, and foreign gas accumulation. J Anesth. 1999;13(3):166-74. doi: 10.1007/s005400050050. No abstract available.
citation: Sakata DJ, Gopalakrishnan NA, Orr JA, White JL, Westenskow DR. Hypercapnic hyperventilation shortens emergence time from isoflurane anesthesia. Anesth Analg. 2007 Mar;104(3):587-91. doi: 10.1213/01.ane.0000255074.96657.39.
citation: Difficult Airway Society Extubation Guidelines Group; Popat M, Mitchell V, Dravid R, Patel A, Swampillai C, Higgs A. Difficult Airway Society Guidelines for the management of tracheal extubation. Anaesthesia. 2012 Mar;67(3):318-40. doi: 10.1111/j.1365-2044.2012.07075.x.