Clinical trial NCT06315712: Inspiratory Muscle Training in Burned Adults
Official title: Effects of Adding Inspiratory Muscle Training to Pulmonary Rehabilitation Program in Adults With Burn Injuries: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Burn Injuries
Lead sponsor: Qassim University
Sponsor class: OTHER
Collaborators: name: Cairo University
First posted: 2024-03-18
Enrollment: 52
Sex: ALL
Minimum age (years): 20
Maximum age (years): 49
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study outlines burn injury impact, emphasizes need for long-term rehabilitation. Study assesses inspiratory muscle training efficacy in improving respiratory strength, lung function, and exercise capacity in adult burn patients.

Detailed description: The study aimed to evaluate the effectiveness of adding inspiratory muscle training to pulmonary rehabilitation in adult burn patients. Fifty-two participants were randomly assigned to either inspiratory muscle training plus pulmonary rehabilitation or pulmonary rehabilitation alone for 8 weeks. Inspiratory muscle training consisted of using a Powerbreathe device for inspiratory muscle strengthening.

Eligibility criteria: Inclusion Criteria:

* Burn-injured adults aged 20-49.
* Admitted to the clinic after acute treatment.
* Recovering from burns affecting at least 20% total body surface area.
* Partial or full-thickness burns.

Exclusion Criteria:

* Smokers.
* had open or unhealed wounds.
* had any known neurological deficit.
* neuromuscular diseases.
* musculoskeletal deformities.
* pulmonary diseases.
* severe cardiac problems.
* inability to participate in regular exercise.

Primary outcomes:
measure: maximal inspiratory pressure
timeFrame: At the beginning of intervention
measure: maximal inspiratory pressure
timeFrame: After 8 weeks of intervention
measure: maximal expiratory pressure
timeFrame: At the beginning of intervention
measure: maximal expiratory pressure
timeFrame: After 8 weeks of intervention
measure: Forced expiratory volume in 1 second
timeFrame: At the beginning of intervention
measure: Forced expiratory volume in 1 second
timeFrame: After 8 weeks of intervention
measure: forced vital capacity
timeFrame: At the beginning of intervention
measure: forced vital capacity
timeFrame: After 8 weeks of intervention
measure: Forced expiratory volume in 1 second/ forced vital capacity ratio
timeFrame: At the beginning of intervention
measure: Forced expiratory volume in 1 second/ forced vital capacity ratio
timeFrame: After 8 weeks of intervention
Secondary outcomes:
measure: Functional exercise capacity
timeFrame: At the beginning of intervention
measure: Functional exercise capacity
timeFrame: After 8 weeks of intervention
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Faculty of Physical Therapy, Cairo University
state: Dokki
Study officials:
affiliation: Cairo University
name: FatmaAlzahraa Kamel, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Qassim University
name: Maged Basha, PhD
role: STUDY_CHAIR
References:
citation: Willis CE, Grisbrook TL, Elliott CM, Wood FM, Wallman KE, Reid SL. Pulmonary function, exercise capacity and physical activity participation in adults following burn. Burns. 2011 Dec;37(8):1326-33. doi: 10.1016/j.burns.2011.03.016. Epub 2011 May 6.
citation: Ozkal O, Topuz S, Karahan S, Erdem MM, Konan A, Yasti AC. Clinical predictors of pulmonary functions, respiratory/peripheral muscle strength and exercise capacity at discharge in adults with burn injury. Disabil Rehabil. 2021 Oct;43(20):2875-2881. doi: 10.1080/09638288.2020.1720320. Epub 2020 Jan 30.
citation: Gittings PM, Grisbrook TL, Edgar DW, Wood FM, Wand BM, O'Connell NE. Resistance training for rehabilitation after burn injury: A systematic literature review & meta-analysis. Burns. 2018 Jun;44(4):731-751. doi: 10.1016/j.burns.2017.08.009. Epub 2017 Oct 7.