Clinical trial NCT02370927: PERFECT Project - Part 2 - Study 2
Official title: Pulse EnRiched Food and Exercise Clinical Trials (PERFECT Project): Part 2 - Acute Effects of Pulse Ingredients in Food Products on Aerobic Endurance and Substrate Oxidation During Exercise, as Well as, the Blood Glucose, Insulin, Lactate and Food Intake Response Following an Endurance Exercise Session in Adults - Study 2
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetes Prevention
Obesity Prevention
Lead sponsor: University of Manitoba
Sponsor class: OTHER
Collaborators: name: Saskatchewan Pulse Growers
name: Alberta Pulse Growers
First posted: 2015-02-25
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The objectives are to test the acute effects of different cereals containing pulse ingredients on: 1) aerobic endurance and substrate oxidation during exercise 2) response of blood glucose, insulin and appetite to an aerobic exercise session, and 3) food intake two hours following the exercise session. The investigators hypothesize that consumption of cereals containing pulse ingredients 60 minutes before exercise will increase aerobic endurance (lower oxygen consumption), decrease carbohydrate oxidation (greater respiratory quotient), and a reduction in lactate production during compared to the same exercise session following the ingestion of a non-pulse food. The investigators also hypothesize that consumption of cereals containing pulse ingredients will lead to lower blood glucose, insulin, appetite and food intake, suggesting lower calorie compensation, following a 60-minute aerobic exercise session compared to the same exercise session following the ingestion of a non-pulse food.


Eligibility criteria: Inclusion Criteria:

* Normoglycemic (\<5.6 mmol/L) and normotensive (systolic blood pressure \<140 mm Hg and diastolic blood pressure below \< 90 mm Hg)
* Body Mass Index of 18.5-29.9 kg/m2

Exclusion Criteria:

* Restrained eaters
* Regularly skip breakfast
* Smokers
* Those on medications that may influence study outcomes or have experienced any gastrointestinal related health conditions/surgeries over the past year
* Those who are active (organized activities or athletic training at a high intensity; ≥ 150 minutes per week of moderate to vigorous physical activity)
* Those unable to walk for an hour continuously

Primary outcomes:
measure: Plasma Glucose Concentrations
timeFrame: 0-240 minutes
measure: Food Intake
timeFrame: at 240 minutes
measure: Subjective Appetite
timeFrame: 0-240 minutes
measure: Exercise intensity
timeFrame: 60-120 minutes
measure: Insulin concentrations
timeFrame: 0-240 minutes
Secondary outcomes:
measure: Palatability measured by Visual Analog Scale questionnaire
timeFrame: 5 and 260 minutes
measure: Physical comfort measured by Visual Analog Scale questionnaire
timeFrame: 0-240 minutes
measure: Energy/fatigue measured by Visual Analog Scale questionnaire
timeFrame: 0 - 240 minutes
measure: Heart rate
timeFrame: 60-120 minutes
measure: Substrate Oxidation
timeFrame: 60-120 minutes
measure: Lactate concentration
timeFrame: 60-120 minutes
Other outcomes:
Locations:
city: Winnipeg
country: Canada
facility: Richardson Centre for Functional Foods and Nutraceuticals
state: Manitoba
Study officials:
affiliation: University of Manitoba, Richardson Centre for Functional Foods and Nutraceuticals
name: Peter JH Jones, PhD
role: PRINCIPAL_INVESTIGATOR
References: