Clinical trial NCT05779410: Vitamin D in Healthy Adults After Strenuous Endurance Exercise
Official title: Effects of Vitamin D Supplementation on Biochemical Responses and Aerobic Capacity After Strenuous Endurance Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: Taipei Medical University
Sponsor class: OTHER
Collaborators: name: Panion & BF Biotech Inc.
First posted: 2023-03-22
Enrollment: 35
Sex: MALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Healthy male participants were divided into vitamin D group and placebo group.
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to investigate the effects of vitamin D supplementation on biochemical response and aerobic capacity after strenuous endurance exercise (SEE).

Detailed description: All participants conducted a graded exercise test on an ergometric bicycle to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 65% VO2max was conducted for a SEE test by ergometric bicycle for 2 hours, followed by increasing 100 RPM until exhaustion. Venous blood samples were drawn before, immediately after, 2-hour after, 4-hour after, 8-hour after, and 24-hour after the SEE test to determine the concentrations of biomarkers. Data was analyzed by Two-way mixed design ANOVA.

Eligibility criteria: Inclusion Criteria:

* The volunteers included have conditions as stated below :

  1. no history of cardiovascular, liver, kidney and diabetes disease
  2. no acute sport injury
  3. male adult whose concentration of 25(OH)D is under 30 ng/mL, and maximal oxygen consumption is over 40 ml/kg/min
  4. did not participated in any clinical trials or research in the last 3 months before our experiment
  5. no supplements were taken during the experimental period
  6. were requested to maintain their regular daily life style and avoid alcohol intake

Exclusion Criteria:

* The volunteers were excluded if they have the situation stated below:

  1. history of cardiovascular, liver, kidney and diabetes disease
  2. acute sport injury
  3. their concentration of 25(OH)D is over 30 ng/mL, or maximal oxygen consumption is under 40 ml/kg/min
  4. participated in any clinical trials or experimental research in the last 3 months before our experiment
  5. taking supplement during the experimental period
  6. did not maintain their regular eating habit or drink alcohol

Primary outcomes:
measure: Concentration of Neutrophil
timeFrame: before exercise
measure: Concentration ofNeutrophil
timeFrame: immediately after exercise
measure: Concentration of Neutrophil
timeFrame: 2-hour after exercise
measure: Concentration of Neutrophil
timeFrame: 4-hour after exercise
measure: Concentration of Neutrophil
timeFrame: 8-hour after exercise
measure: Concentration of Neutrophil
timeFrame: 24-hour after exercise
measure: Concentration of eosinophil
timeFrame: before exercise
measure: Concentration of eosinophil
timeFrame: immediately after exercise
measure: Concentration of eosinophil
timeFrame: 2-hour after exercise
measure: Concentration of eosinophil
timeFrame: 4-hour after exercise
measure: Concentration of eosinophil
timeFrame: 8-hour after exercise
measure: Concentration of eosinophil
timeFrame: 24-hour after exercise
measure: Concentration of basophil
timeFrame: before exercise
measure: Concentration of basophil
timeFrame: immediately after exercise
measure: Concentration of basophil
timeFrame: 2-hour after exercise
measure: Concentration of basophil
timeFrame: 4-hour after exercise
measure: Concentration of basophil
timeFrame: 8-hour after exercise
measure: Concentration of basophil
timeFrame: 24-hour after exercise
measure: Concentration of monocyte
timeFrame: before exercise
measure: Concentration of monocyte
timeFrame: immediately after exercise
measure: Concentration of monocyte
timeFrame: 2-hour after exercise
measure: Concentration of monocyte
timeFrame: 4-hour after exercise
measure: Concentration of monocyte
timeFrame: 8-hour after exercise
measure: Concentration of monocyte
timeFrame: 24-hour after exercise
measure: Concentration of lymphocyte
timeFrame: before exercise
measure: Concentration of lymphocyte
timeFrame: immediately after exercise
measure: Concentration of lymphocyte
timeFrame: 2-hour after exercise
measure: Concentration of lymphocyte
timeFrame: 4-hour after exercise
measure: Concentration of lymphocyte
timeFrame: 8-hour after exercise
measure: Concentration of lymphocyte
timeFrame: 24-hour after exercise
measure: Concentration of CD4+
timeFrame: before exercise
measure: Concentration of CD4+
timeFrame: immediately after exercise
measure: Concentration of CD4+
timeFrame: 2-hour after exercise
measure: Concentration of CD4+
timeFrame: 4-hour after exercise
measure: Concentration of CD4+
timeFrame: 8-hour after exercise
measure: Concentration of CD4+
timeFrame: 24-hour after exercise
measure: Concentration of CD8+
timeFrame: before exercise
measure: Concentration of CD8+
timeFrame: immediately after exercise
measure: Concentration of CD8+
timeFrame: 2-hour after exercise
measure: Concentration of CD8+
timeFrame: 4-hour after exercise
measure: Concentration of CD8+
timeFrame: 8-hour after exercise
measure: Concentration of CD8+
timeFrame: 24-hour after exercise
measure: Concentration of CD19+
timeFrame: before exercise
measure: Concentration of CD19+
timeFrame: immediately after exercise
measure: Concentration of CD19+
timeFrame: 2-hour after exercise
measure: Concentration of CD19+
timeFrame: 4-hour after exercise
measure: Concentration of CD19+
timeFrame: 8-hour after exercise
measure: Concentration of CD19+
timeFrame: 24-hour after exercise
measure: Concentration of CD56+
timeFrame: before exercise
measure: Concentration of CD56+
timeFrame: immediately after exercise
measure: Concentration of CD56+
timeFrame: 2-hour after exercise
measure: Concentration of CD56+
timeFrame: 4-hour after exercise
measure: Concentration of CD56+
timeFrame: 8-hour after exercise
measure: Concentration of CD56+
timeFrame: 24-hour after exercise
measure: Concentration of IgA
timeFrame: before exercise
measure: Concentration of IgA
timeFrame: immediately after exercise
measure: Concentration of IgA
timeFrame: 2-hour after exercise
measure: Concentration of IgA
timeFrame: 4-hour after exercise
measure: Concentration of IgA
timeFrame: 8-hour after exercise
measure: Concentration of IgA
timeFrame: 24-hour after exercise
measure: Concentration of Cathelicidin
timeFrame: before exercise
measure: Concentration of Cathelicidin
timeFrame: immediately after exercise
measure: Concentration of Cathelicidin
timeFrame: 2-hour after exercise
measure: Concentration of Cathelicidin
timeFrame: 4-hour after exercise
measure: Concentration of Cathelicidin
timeFrame: 8-hour after exercise
measure: Concentration of Cathelicidin
timeFrame: 24-hour after exercise
measure: Concentration of TNF-α
timeFrame: before exercise
measure: Concentration of TNF-α
timeFrame: immediately after exercise
measure: Concentration of TNF-α
timeFrame: 2-hour after exercise
measure: Concentration of TNF-α
timeFrame: 4-hour after exercise
measure: Concentration of TNF-α
timeFrame: 8-hour after exercise
measure: Concentration of TNF-α
timeFrame: 24-hour after exercise
measure: Concentration of IL-1β
timeFrame: before exercise
measure: Concentration of IL-1β
timeFrame: immediately after exercise
measure: Concentration of IL-1β
timeFrame: 2-hour after exercise
measure: Concentration of IL-1β
timeFrame: 4-hour after exercise
measure: Concentration of IL-1β
timeFrame: 8-hour after exercise
measure: Concentration of IL-1β
timeFrame: 24-hour after exercise
measure: Concentration of IFN-γ
timeFrame: before exercise
measure: Concentration of IFN-γ
timeFrame: immediately after exercise
measure: Concentration of IFN-γ
timeFrame: 2-hour after exercise
measure: Concentration of IFN-γ
timeFrame: 4-hour after exercise
measure: Concentration of IFN-γ
timeFrame: 8-hour after exercise
measure: Concentration of IFN-γ
timeFrame: 24-hour after exercise
measure: Concentration of IL-2
timeFrame: before exercise
measure: Concentration of IL-2
timeFrame: immediately after exercise
measure: Concentration of IL-2
timeFrame: 2-hour after exercise
measure: Concentration of IL-2
timeFrame: 4-hour after exercise
measure: Concentration of IL-2
timeFrame: 8-hour after exercise
measure: Concentration of IL-2
timeFrame: 24-hour after exercise
measure: Concentration of IL-4
timeFrame: before exercise
measure: Concentration of IL-4
timeFrame: immediately after exercise
measure: Concentration of IL-4
timeFrame: 2-hour after exercise
measure: Concentration of IL-4
timeFrame: 4-hour after exercise
measure: Concentration of IL-4
timeFrame: 8-hour after exercise
measure: Concentration of IL-4
timeFrame: 24-hour after exercise
measure: Concentration of IL-8
timeFrame: before exercise
measure: Concentration of IL-8
timeFrame: immediately after exercise
measure: Concentration of IL-8
timeFrame: 2-hour after exercise
measure: Concentration of IL-8
timeFrame: 4-hour after exercise
measure: Concentration of IL-8
timeFrame: 8-hour after exercise
measure: Concentration of IL-8
timeFrame: 24-hour after exercise
measure: Concentration of IL-10
timeFrame: before exercise
measure: Concentration of IL-10
timeFrame: immediately after exercise
measure: Concentration of IL-10
timeFrame: 2-hour after exercise
measure: Concentration of IL-10
timeFrame: 4-hour after exercise
measure: Concentration of IL-10
timeFrame: 8-hour after exercise
measure: Concentration of IL-10
timeFrame: 24-hour after exercise
measure: Concentration of TBARS
timeFrame: before exercise
measure: Concentration of TBARS
timeFrame: immediately after exercise
measure: Concentration of TBARS
timeFrame: 2-hour after exercise
measure: Concentration of TBARS
timeFrame: 4-hour after exercise
measure: Concentration of TBARS
timeFrame: 8-hour after exercise
measure: Concentration of TBARS
timeFrame: 24-hour after exercise
measure: Concentration of PC
timeFrame: before exercise
measure: Concentration of PC
timeFrame: immediately after exercise
measure: Concentration of PC
timeFrame: 2-hour after exercise
measure: Concentration of PC
timeFrame: 4-hour after exercise
measure: Concentration of PC
timeFrame: 8-hour after exercise
measure: Concentration of PC
timeFrame: 24-hour after exercise
measure: Concentration of SOD
timeFrame: before exercise
measure: Concentration of SOD
timeFrame: immediately after exercise
measure: Concentration of SOD
timeFrame: 2-hour after exercise
measure: Concentration of SOD
timeFrame: 4-hour after exercise
measure: Concentration of SOD
timeFrame: 8-hour after exercise
measure: Concentration of SOD
timeFrame: 24-hour after exercise
measure: Concentration of catalase
timeFrame: before exercise
measure: Concentration of catalase
timeFrame: immediately after exercise
measure: Concentration of catalase
timeFrame: 2-hour after exercise
measure: Concentration of catalase
timeFrame: 4-hour after exercise
measure: Concentration of catalase
timeFrame: 8-hour after exercise
measure: Concentration of catalase
timeFrame: 24-hour after exercise
measure: Concentration of GPx
timeFrame: before exercise
measure: Concentration of GPx
timeFrame: immediately after exercise
measure: Concentration of GPx
timeFrame: 2-hour after exercise
measure: Concentration of GPx
timeFrame: 4-hour after exercise
measure: Concentration of GPx
timeFrame: 8-hour after exercise
measure: Concentration of GPx
timeFrame: 24-hour after exercise
measure: Concentration of CK
timeFrame: before exercise
measure: Concentration of CK
timeFrame: immediately after exercise
measure: Concentration of CK
timeFrame: 2-hour after exercise
measure: Concentration of CK
timeFrame: 4-hour after exercise
measure: Concentration of CK
timeFrame: 8-hour after exercise
measure: Concentration of CK
timeFrame: 24-hour after exercise
measure: Concentration of LDH
timeFrame: before exercise
measure: Concentration of LDH
timeFrame: immediately after exercise
measure: Concentration of LDH
timeFrame: 2-hour after exercise
measure: Concentration of LDH
timeFrame: 4-hour after exercise
measure: Concentration of LDH
timeFrame: 8-hour after exercise
measure: Concentration of LDH
timeFrame: 24-hour after exercise
measure: Concentration of IL-6
timeFrame: before exercise
measure: Concentration of IL-6
timeFrame: immediately after exercise
measure: Concentration of IL-6
timeFrame: 2-hour after exercise
measure: Concentration of IL-6
timeFrame: 4-hour after exercise
measure: Concentration of IL-6
timeFrame: 8-hour after exercise
measure: Concentration of IL-6
timeFrame: 24-hour after exercise
measure: Concentration of CRP
timeFrame: before exercise
measure: Concentration of CRP
timeFrame: immediately after exercise
measure: Concentration of CRP
timeFrame: 2-hour after exercise
measure: Concentration of CRP
timeFrame: 4-hour after exercise
measure: Concentration of CRP
timeFrame: 8-hour after exercise
measure: Concentration of CRP
timeFrame: 24-hour after exercise
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University
Study officials:
References: