louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05841368: DELIRIUM SCREENING, INCIDENCE AND MANAGEMENT OBSERVATIONAL STUDY IN 2024 - THE CZECH REPUBLIC
Official title: DELIRIUM SCREENING, INCIDENCE AND MANAGEMENT OBSERVATIONAL STUDY IN 2024 - THE CZECH REPUBLIC
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Delirium
Keywords: Delirium
Screening
Therapy
CAM-ICU
Lead sponsor: Brno University Hospital
Sponsor class: OTHER
Collaborators: name: Masaryk University
name: Department of Neurology, University Hospital Brno
First posted: 2023-05-03
Enrollment: 2000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: ICU patients

Brief summary: Delirium in intensive care unit (ICU) settings is a frequent complication with reported prevalence of 31%. Recent data has revealed the connection between delirium and increased 30days mortality after hospital release and the higher incidence of readmission to emergency. Despite the high prevalence and well described validation methods for screening, the precise incidence remains unclear due to insufficient screening in ICU settings. The incidence of delirium in Czech Republic remains undescribed, beside data reported from neurointensive care patients and single-center general critically ill patients data.

Detailed description: All patients fulfilling inclusion criteria in intensive care settings in involved ICUs in Czech Republic will be included into the study. Data will be recorded for 1 consequent month. Basic demography will be evaluated. In each patient standard delirium screening based on the institutional ICU rules will be performed. If no screening method were set,Confusion Assessment Method - CAM-ICU for adult and pediatric Confusion Assessment Method -pCAM-ICU for pediatric patients would be used together with delirium management, restrain procedures, sedative/neuroleptics administration, 28-days mortality. All data will be recorded into to predefined eCRF.

Eligibility criteria: Inclusion Criteria:

* Patients in ICU settings
* in defined time interval of the study

Exclusion Criteria:

* duration of ICU stay shorter than 24 hours

Primary outcomes:
measure: Delirium prevalence
timeFrame: during 30 days after study initiation in selected ICU
Secondary outcomes:
measure: Delirium management
timeFrame: during 30 days after study initiation in selected ICU
measure: Inhospital mortality
timeFrame: during 30 days after study initiation in selected ICU
measure: 28-days mortality
timeFrame: after patient inclusion into the study
measure: 90-days mortality
timeFrame: after patient inclusion into the study
Other outcomes:
Locations:
city: Brno
country: Czechia
facility: Brno University Hospital
state: South Moravian Region
Study officials:
affiliation: Department of paediatric anaesthesia and intensive care medicine
name: Petr Stourac, prof. MD., Ph.D., MBA
role: STUDY_CHAIR
References:
Clinical trial NCT04216368: Balance Trainning for Sarcopenic Inpatients Aged 80+ Years
Official title: Effect of Balance Training on Mobility and Activities of Daily Living in Sarcopenic Inpatients Aged 80+Years
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sarcopenia
Lead sponsor: West China Hospital
Sponsor class: OTHER
First posted: 2020-01-02
Enrollment: 60
Sex: ALL
Minimum age (years): 80
Maximum age (years): 99
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Resistance training and aerobic exercise have been recommended for sarcopenic patients. However, whether balance training would further benefit for sarcopenic patients on the basis of resistance training and aerobic exercise remains unclear. The purpose of this study is to explore the effect of balance training on improving the mobility of elderly patients with sarcopenia. Balance training involves doing exercises that strengthen the muscles that help keep the aged upright, including the legs and core. These kinds of exercises can improve stability and help prevent falls.


Eligibility criteria: Inclusion Criteria：

* Sarcopenia defined by the Asia Working Group of Sarcopenia (AWGS)
* Agree to participant this study and sign the informed consent
* Aged 80 years or over

Exclusion Criteria:

* Patients who could not follow the training plan due to cognitive impairment, emotional problems or any other reasons;
* Severe heart and lung diseases;
* Renal insufficiency;
* Any type of tumor;
* Bedridden patients

Primary outcomes:
measure: Fall rates
timeFrame: One year
measure: The change of activities of daily living
timeFrame: 3 Months
Secondary outcomes:
measure: The change of usual gait speed
timeFrame: 3 months
measure: The change of handgrip strength
timeFrame: 3 months
measure: The change of the score of Short Physical Performance Battery
timeFrame: 3 Months
measure: The change of the score of Timed Up and Go test
timeFrame: 3 Months
Other outcomes:
Locations:
city: Chengdu
country: China
facility: West China Hospital，Sichuan University
state: Sichuan
Study officials:
affiliation: West China Hospital
name: Ming Yang
role: STUDY_DIRECTOR
affiliation: West China Hospital
name: Jiaojiao Jiang
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01719068: Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos
Official title: Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Mesothelioma
Lung Cancer
Keywords: Mesothelioma
Lung Cancer
Early Detection
Lead sponsor: British Columbia Cancer Agency
Sponsor class: OTHER
Collaborators: name: BC Cancer Foundation
First posted: 2012-11-01
Enrollment: 200
Sex: ALL
Minimum age (years): 50
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Workers in British Columbia who have been exposed to asbestos.

Brief summary: This is a pilot study that aims to develop a lung cancer screening program for workers in British Columbia, Canada exposed to asbestos who are at risk of developing lung cancer/pleural mesothelioma. This is high risk population is at of respiratory system diseases as a result of their occupational exposures. Additionally, knowledge garnered from this study will allow us to develop other studies that will further our understanding of asbestos related lung cancer and mesothelioma.


Eligibility criteria: Inclusion Criteria:

* Women or men age 50 to 79 years
* history of exposure to asbestos at work and one or more of the following:

  * lung cancer risk ≥2% over 3 years or
  * asbestosis or pleural plaques on a chest x-ray or
  * abnormal auto-antibodies level using the EarlyCDT test
* Capable of providing informed consent for screening procedures (low dose spiral CT, lung function, blood biomarkers).

Exclusion Criteria:

* Any medical condition, such as severe heart disease (e.g. unstable angina, chronic congestive heart failure), acute or chronic respiratory failure, or any disorder, that in the opinion of the physician unlikely to benefit from screening due to shortened life-expectancy from co-existing illnesses
* Have been previously diagnosed with mesothelioma
* Have had other cancer within the past 5 years with the exception of the following cancers: non-melanomatous skin cancer,localized prostate cancer, carcinoma in situ (CIS) of the cervix, or superficial bladder cancer. Treatment of the exceptions must have ended \>6 months before registration into this study
* Pregnancy
* Unwilling to have a low dose CT scan of chest
* Unwilling to sign a consent

Primary outcomes:
measure: Development of Model to Predict Workers at highest risk of lung cancer/mesothelioma
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Vancouver
country: Canada
facility: British Columbia Cancer Agency
state: British Columbia
Study officials:
affiliation: British Columbia Cancer Agency
name: Stephen Lam
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01364272: Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia
Official title: Investigation of Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Trigeminal Neuralgia
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2011-06-02
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients age 18 years and older with typical trigeminal neuralgia, as determined by diagnostic criteria set by the International Headache Society, who was treated with SRS.

Brief summary: Trigeminal neuralgia or tic douloureux is severe, often debilitating, facial pain that significantly impairs the patient's quality of life and health. Stereotactic radiosurgery has been shown to provide pain relief in majority of patients treated. However, a common side effect of radiosurgery is facial numbness. To better understand how radiosurgery can bring about pain relief and facial numbness, we are conducting a study in which brain MRI scans will be done following stereotactic radiosurgery to learn if there are any changes in the MRI scans that correlate with symptoms.


Eligibility criteria: Inclusion Criteria:

* All patients age 18 years and older with typical trigeminal neuralgia, as determined by diagnostic criteria set by the International Headache Society, who are 1) intolerant of or refractory to medical management and 2) not candidates for or refusing a surgical micro-vascular decompression, will be evaluated for treatment with SRS.
* ECOG or Karnofsky Performance Status will not be employed, but patients must be sufficiently healthy to tolerate all study procedures.
* Patient must exhibit the ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria:

* Exclusion criteria
* Patients who present with pre-existing facial numbness.
* Patients MRI contraindications (e.g., pacemaker or defibrillator, cochlear implant, brain aneurysm clip, etc.)
* Patients who have previously been treated with MVD.
* Patients who have previously had an ablative treatment, including prior SRS.
* Pediatric patients (age \<18), pregnant women, and patients who are unable to give informed consent will be excluded.

Primary outcomes:
measure: DTI MRI findings
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University School of Medicine
state: California
Study officials:
affiliation: Stanford University
name: Clara Choi
role: PRINCIPAL_INVESTIGATOR
affiliation: Stanford University
name: Scott Soltys
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01664572: Methodological Issues and Laser Speckle Contrast Imaging
Official title: Methodological Issues of Laser Speckle Contrast Imaging for Studying Microcirculation.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Microvascular Function
Keywords: laser Doppler flowmetry, skin blood flow
Lead sponsor: University Hospital, Angers
Sponsor class: OTHER_GOV
First posted: 2012-08-14
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Residents of France

Brief summary: Microcirculation, especially skin microcirculation, is a window towards systemic vascular function in magnitude and underlying mechanisms. Different techniques have been developed to assess the microcirculation. Among these techniques, laser technology is used to perform non-invasive microvascular assessments. Although this technique is widely used, different methodological issues remain. This study aims at defining the way to use lasers for clinical use.


Eligibility criteria: Inclusion Criteria:

* age \> 18years old
* subject without any known cardiovascular disease

Exclusion Criteria:

* pregnancy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Angers cedex 9
country: France
facility: University Hospital
Study officials:
References:
citation: Omarjee L, Signolet I, Humeau-Heutier A, Martin L, Henrion D, Abraham P. Optimisation of movement detection and artifact removal during laser speckle contrast imaging. Microvasc Res. 2015 Jan;97:75-80. doi: 10.1016/j.mvr.2014.09.005. Epub 2014 Sep 28.
citation: Puissant C, Abraham P, Durand S, Humeau-Heurtier A, Faure S, Leftheriotis G, Mahe G. Assessment of endothelial function by acetylcholine iontophoresis: impact of inter-electrode distance and electrical cutaneous resistance. Microvasc Res. 2014 May;93:114-8. doi: 10.1016/j.mvr.2014.04.001. Epub 2014 Apr 13.
citation: Puissant C, Abraham P, Durand S, Humeau-Heurtier A, Faure S, Leftheriotis G, Rousseau P, Mahe G. Reproducibility of non-invasive assessment of skin endothelial function using laser Doppler flowmetry and laser speckle contrast imaging. PLoS One. 2013 Apr 19;8(4):e61320. doi: 10.1371/journal.pone.0061320. Print 2013.
Clinical trial NCT00225472: Organ Preservation Media Investigation
Official title: Organ Preservation Media Investigation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Kidney Transplant
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
First posted: 2005-09-23
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: Kidney transplantation remains limited by four problems: 1) a too high rate of delayed graft function, 2) early loss of kidneys from chronic rejection, 3) donor kidney shortages, and 4) the need for immunomodulating treatments. Improved cold storage methods can significantly impact on the first 3 of these 4 major problems. The device to be tested is a modification of the existing Viaspan organ preservation solution. The modification of this solution combines four compounds: Bovine neutrophil peptide-1 (BNP-1), Substance P (SP), Insulin-like growth factor-1 (IGF-1), and Nerve Growth Factor (NGF). This solution will be added to Viaspan for preservation of donor kidneys. Preclinical data indicates that trophic factor deprivation during cold storage is a significant and previously unrecognized mechanism of injury in cold stored kidneys. The aim of this study is improved graft function, decreasing early graft loss due to rejection, and decreasing the donor organ shortage.


Eligibility criteria: Inclusion Criteria:

* first renal transplant, PRA's \<20%

Exclusion Criteria:

* PRA's greater than 20%
* Subjects who are receiving a non-primary renal transplant
* Subjects under the age of 18
* Pregnant or nursing women

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Madison
country: United States
facility: University of Wisconsin Hospital and Clinics
state: Wisconsin
Study officials:
affiliation: University of Wisconsin Medical School
name: Anthony Dalessandro, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00551668: A Prospective, Randomized Study of Operative and Nonoperative Treatment for Primary Traumatic Patellar Dislocation
Official title: A Prospective, Randomized Study of Operative and Nonoperative Treatment for Primary Traumatic Patellar Dislocation in Young Adults With a Median 7-Year Follow-Up
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Patellar Dislocation
Lead sponsor: Finnish Defense Forces
Sponsor class: OTHER_GOV
First posted: 2007-10-31
Enrollment: 40
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The objective of this prospective, randomized cohort study was to evaluate the clinical results between operative and nonoperative treatment of primary patellar dislocation.

Detailed description: There is no consensus about management of acute traumatic primary patellar dislocations in young physically active adults. Acute lateral patellar dislocation is a relatively common injury among young adults. Proper treatment for this condition has been researched for decades. However, there is a lack of prospective randomized studies to evaluate the different treatment options for traumatic primary patellar dislocations. Therefore a prospective, randomized study was designed with the aim to compare the outcome of operative versus nonoperative treatment of primary traumatic patellar dislocations in young adults.

Eligibility criteria: Inclusion Criteria:

* An acute primary traumatic patellar dislocation

Exclusion Criteria:

* Previous dislocation or subluxation of the patella
* Pre-existing ipsilateral or contralateral knee pathology
* Previous knee trauma or patellar fracture.

Primary outcomes:
measure: Number of redislocations
timeFrame: 7 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Centre for Military Medicine, Lahti, Finland
name: Harri Pihlajamäki, M.D., Ph.D.
role: STUDY_DIRECTOR
References:
Clinical trial NCT03821168: The Effect of Intravitreal Erythropoietin Injection for Refractive Diabetic Macular Edema
Official title: The Effect of Intravitreal Erythropoietin Injection for Refractive Diabetic Macular Edema
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
PHASE3
Conditions: Refractory Diabetic Macular Edema
Lead sponsor: Shahid Beheshti University of Medical Sciences
Sponsor class: OTHER
First posted: 2019-01-29
Enrollment: 58
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: after advent of RD photoreceptor degeneration Occurred. This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened .

Process of degeneration begins from first hours of RD establishment Neuroprotection of photoreceptor following RD is a novel and debatable discussion encountered in recent years .

How to stop this phenomena and neuroprotective agent role in this issue are a new interest of researches.

In the study investigators are planning to perform a clinical trial to demonstrate the minocycline neuroprotective effect in a double blind design as this impact has been implicated previously in a animal study.


Eligibility criteria: Inclusion Criteria:

* Patient with refractory diabetic macular edema at least one month after third injection

Exclusion Criteria:

* previous vitreoretinal surgery previous glaucoma surgery glaucomatous patient open heart surgery active proliferative diabetic retinopathy one eye patients vitreous hemorrhage

Primary outcomes:
measure: best corrected visual acuity
timeFrame: 1 month
Secondary outcomes:
measure: Optical coherence tomography
timeFrame: 1 month
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Ophthalmic Research Center
Study officials:
References:
citation: Entezari M, Flavarjani ZK, Ramezani A, Nikkhah H, Karimi S, Moghadam HF, Daftarian N, Yaseri M. Combination of intravitreal bevacizumab and erythropoietin versus intravitreal bevacizumab alone for refractory diabetic macular edema: a randomized double-blind clinical trial. Graefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2375-2380. doi: 10.1007/s00417-019-04383-2. Epub 2019 Aug 10.
Clinical trial NCT04168372: Fructose: Substrate, Stimulus, or Both?
Official title: Fructose: Substrate, Stimulus, or Both?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Insulin Resistance
Insulin Sensitivity
Pre Diabetes
Keywords: Fructose
Glucose
Lipogenesis
Lead sponsor: Touro University, California
Sponsor class: OTHER
First posted: 2019-11-19
Enrollment: 35
Sex: ALL
Minimum age (years): 20
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This objective of this study is to use sensitive methodology under controlled conditions to investigate the mechanisms by which fructose consumption contributes to excess fatty acid synthesis and elevations in blood glucose levels following consumption of meals containing fructose.


Eligibility criteria: Inclusion Criteria:

* Body Mass Index 22 to 35 kg/m2
* Prediabetic (HbA1c 5.7% to 6.5%) or hyperinsulinemic (fasting insulin ≥12 µIU/mL) but non-diabetic (fasting glucose \<126mg/dL and HbA1c \< 6.5%) ; or normal control (fasting insulin \<10 µIU/mL, fasting glucose \<100 mg/dL, and HbA1c \< 5.7%)

Exclusion Criteria:

* Pregnancy or lactation within the past six months
* Type 1 or 2 diabetes mellitus
* History of liver disease or aspartate aminotransferase (AST) and alanine aminotransferase (ALT) 2x the upper limit of normal (ULN);
* Fasting triglyceride or total cholesterol levels above 95th percentile for age and sex;
* Hemoglobin or hematocrit below the lower limit of normal for sex;
* Report of hepatitis or HIV infection;
* History of cancer, use of any anti-diabetic medications or hypolipidemic agents in the past six months;
* History of surgical procedure for obesity;
* Self-reported change in body weight \>5% in the past six months;
* History of other conditions known to affect insulin sensitivity and lipid metabolism;
* Known intolerance to acetaminophen or components of the liquid test meals.

Primary outcomes:
measure: Hepatic fractional de novo lipogenesis in triglyceride rich lipoprotein (TRL)
timeFrame: 6 hours
measure: Rate of appearance of UDP-glucose
timeFrame: 6 hours
measure: Rate of appearance of blood glucose from gluconeogenesis
timeFrame: 6 hours
Secondary outcomes:
measure: Serum triglyceride concentration
timeFrame: 6 hours
measure: Serum glucose concentration
timeFrame: 6 hours
measure: Serum lactate concentration
timeFrame: 6 hours
measure: Serum insulin concentration
timeFrame: 6 hours
measure: Serum free fatty acid concentration
timeFrame: 6 hours
measure: Enteral (chylomicron) fractional de novo lipogenesis (DNL)
timeFrame: 6 hours
measure: Hepatic (VLDL) fractional de novo lipogenesis (DNL)
timeFrame: 6 hours
measure: Extrasplanchnic fructose
timeFrame: 6 hours
measure: Whole body fructose oxidation
timeFrame: 6 hours
Other outcomes:
Locations:
city: Vallejo
country: United States
facility: Touro University California
state: California
Study officials:
affiliation: Touro University, California
name: Jean-Marc Schwarz, PhD
role: PRINCIPAL_INVESTIGATOR
References: