louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06277895: VOCs in Patients With Acute Cardiogenic Chest Pain
Official title: Application of Emergency Rapid Detection of Expiratory Volatile Organic Compounds (VOCs) in Patients With Acute Cardiogenic Chest Pain
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Acute Coronary Syndrome
Acute Aortic Syndrome
Lead sponsor: Qilu Hospital of Shandong University
Sponsor class: OTHER
First posted: 2024-02-26
Enrollment: 1400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The goal of this observation study is to compare VOCs in cardiogenic chest pain population/health conditions, to answer：Establishment and promotion of the application system of emergency rapid detection of expiratory Volatile Organic Compounds (VOCs) in patients with acute cardiogenic chest pain

1. VOCs levels were measured at baseline in healthy people, and markers of VOCs that could be used to identify acute cardiogenic chest pain were sought.
2. The relationship between abnormal VOCs (mainly aldehydes) and prognosis of patients and the correlation with Super-score for early warning of acute heart failure.


Eligibility criteria: Inclusion Criteria:

Observation group inclusion criteria:

1. Over 18 years old, male or female;
2. Patients with acute cardiogenic chest pain (see diagnostic criteria);
3. Patient\&#39;s informed consent.

Inclusion criteria of healthy control group:

1. Over 18 years old, male or female;
2. Centerless cerebrovascular disease, lung disease, no abnormal liver and kidney function, no acute infection recently;
3. Informed consent.

Exclusion Criteria:

1. The patient had difficulty in collecting breath;
2. Patients with terminal illness or receiving palliative care;
3. Have participated in other clinical studies or consider it inappropriate to participate in this study.

Primary outcomes:
measure: Baseline VOCs (aldehydes) levels in healthy population
timeFrame: Baseline
Secondary outcomes:
measure: MACE in patients with cardiogenic chest pain
timeFrame: From enrollment to the end of treatment at 30 days
Other outcomes:
Locations:
city: Jinan
country: China
facility: Qilu hospital
state: Shandong
Study officials:
References:
Clinical trial NCT04869995: Behav'Robot: Understanding the Surgeon Behavior During Robot-assisted Surgery
Official title: Behav'Robot: Understanding the Surgeon Behavior During Robot-assisted Surgery (a Qualitative Study)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Robotic Surgical Procedures
Lead sponsor: Centre Hospitalier de Troyes
Sponsor class: OTHER
First posted: 2021-05-03
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study participants will comprise senior abdominal and pelvic cavity surgeons (i.e., visceral surgeons, gynecologist surgeons, and urologists) having completed their robot-assisted surgery training, and commonly doing laparoscopic surgery.

Brief summary: Robot-assisted surgery is spreading since the last decade, but little is known about the impact of the use of the robot on surgeon practices and behavior in the operation theatre.

Interviewing senior surgeons trained for doing robot-assisted surgery, this qualitative study is expected to provide new insights to understand the surgeons' behavioral changes when using a robot.

This study will contribute to improving training programs in robot-assisted surgery.


Eligibility criteria: Inclusion Criteria:

* Senior abdominal and pelvic cavity surgeons (i.e., visceral surgeons, gynecologist surgeons, or urologists).
* Having completed a robot-assisted training
* Commonly doing laparoscopic surgery

Exclusion Criteria:

* Those who refuse to participate in the study

Primary outcomes:
measure: Elicitation of the surgeons' perception
timeFrame: = interview duration (about 30 minutes)
Secondary outcomes:
Other outcomes:
Locations:
city: Troyes
country: France
facility: Centre Hospitalier de Troyes
state: Grand-Est
Study officials:
References:
citation: Cormi C, Parpex G, Julio C, Ecarnot F, Laplanche D, Vannieuwenhuyse G, Duclos A, Sanchez S. Understanding the surgeon's behaviour during robot-assisted surgery: protocol for the qualitative Behav'Robot study. BMJ Open. 2022 Apr 7;12(4):e056002. doi: 10.1136/bmjopen-2021-056002.
Clinical trial NCT00005295: Idiopathic Pulmonary Fibrosis: a Case-control Study
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Lung Diseases
Pulmonary Fibrosis
Lung Diseases, Interstitial
Lead sponsor: University of New Mexico
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2000-05-26
Sex: MALE
Minimum age (years): 0
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: To determine risk factors for idiopathic pulmonary fibrosis.

Detailed description: BACKGROUND:

Idiopathic pulmonary fibrosis is a progressive and generally fatal disease that causes fibrosis of the pulmonary interstitium. While many environmental agents cause diseases clinically similar, the etiology of idiopathic pulmonary fibrosis suggests that environmental agents could incite the tissue injury that results in the disease; furthermore, host characteristics could have an important role in determining the magnitude of the host response to the agent initiating injury.

DESIGN NARRATIVE:

In this case control study, cases were ascertained at the multiple collaborating centers and controls were identified by telephone screening. A telephone interview was conducted to collect information needed to test hypotheses concerning cigarette smoking, occupational exposure, indoor exposures, other environmental factors, and host factors. To limit disease misclassification, two pathologists experienced with interstitial diseases of the lung reviewed histopathological material from all cases to exclude entities other than interstitial lung fibrosis and to fully characterize the cases clinically. The mortality of this large series of cases was also described.

Eligibility criteria: No eligibility criteria

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Baumgartner KB, Samet JM, Stidley CA, Colby TV, Waldron JA. Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1997 Jan;155(1):242-8. doi: 10.1164/ajrccm.155.1.9001319.
citation: Coultas DB, Gong H Jr, Grad R, Handler A, McCurdy SA, Player R, Rhoades ER, Samet JM, Thomas A, Westley M. Respiratory diseases in minorities of the United States. Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 2):S93-131. doi: 10.1164/ajrccm/149.3_Pt_2.S93. No abstract available.
Clinical trial NCT01921595: Impact of Balanced Slat Colloid HES 130/0.42 on Coagulation Profiles in Patients Undergoing Spinal Cord Tumor Surgery
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Coagulation
Keywords: balanced salt colloid, coagulation profiles, spinal cord tumor
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2013-08-13
Enrollment: 6
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of study is to compare the effect of coagulation profile in patients receiving intraoperative balanced salt colloid undergoing spinal cord tumor surgery.


Eligibility criteria: Inclusion Criteria:

* adult patients over the age of 20 scheduled for spinal tumor removal and fixation

Exclusion Criteria:

* 1. Renal failure 2. Preexisting congestive heart failure(NYHA III \~ IV) 3. Anemia 4. Coagulopathy 5. Abnormal liver function 6. Anti coagulation/Anti platelet ,edication 7. Foreigner, illiterate 8. Disabled person,

Primary outcomes:
measure: Compare the effect of coagulation profile in patients receiving intraoperative balanced salt colloid undergoing spinal cord tumor surgery.
timeFrame: up to 24hrs after anesthesia induction
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Study officials:
References:
Clinical trial NCT00630695: Prevention of Lymphorrhea by Lanreotide in Axillary Dissection for Breast Cancer
Official title: Evaluation of the Efficacity of Lanreotide LP 90 mg to Minimized the Lymphorrhea Post Axillary Lymphadenectomy in Breast Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Lymphocele
Keywords: Axillary lymphocele breast cancer
Lead sponsor: University Hospital, Limoges
Sponsor class: OTHER
Collaborators: name: Ipsen
First posted: 2008-03-07
Enrollment: 148
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Injection the day before surgery of 90 mg of Lanreotide LP sub-cutaneously or placebo. Evaluation of the lymphorrhea in the 2 arms of the study

Detailed description: Patients will be recruited among patient refered to our department for a breast cancer and needing an axillary dissection. Enrolled patients will have an injection of Lanreotide or placebo the day before surgery when they arrive in their room. The quantity of lymph in axillary drain will by daily noted until day 4. The patient will be evaluated at D15, D30 and M6 for pain, lymphocele and adverse events.

Data will be compared in the 2 groups.

Eligibility criteria: Inclusion Criteria:

* Adult patient (\> 18 years),
* Patient undergoing an axillary lymphadenectomy for breast cancer
* Patient giving her agreement after being informed

Exclusion Criteria:

* Patients that don't understand the trial
* Type 2 diabetic patients
* Cyclosporine treatment
* Biliary lithiasis
* Pregnancy or breast feeding
* Allergic reaction to Lanréotide or same class treatments
* Patient included in another trial within the last 30 days

Primary outcomes:
measure: Quantity of lymph collected by the drain
timeFrame: D4 post operativly
Secondary outcomes:
measure: Prevention of lymphocele
timeFrame: D15, D30 and M6
Other outcomes:
Locations:
city: Limoges
country: France
facility: Hôpital Mère Enfant- CHU de Limoges
Study officials:
affiliation: University Hospital, Limoges
name: Yves Aubard, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT02281695: PEEP Influence on Gas Exchange During Early Weaning
Official title: The Influence of Different PEEP Values on Gas Exchange in Spontaneously Breathing Patients During Early Weaning
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Respiratory Failure
Lead sponsor: Marienhospital Osnabrück
Sponsor class: OTHER
First posted: 2014-11-02
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to determine the differences in oxygenation and decarboxylation between two weaning processes.

Detailed description: First, during controlled mechanical ventilation all patients will be ventilated for 5 minutes with 100% oxygen. After 5 minutes an PaO2/FiO2 will be calculated and compared with a PaO2/FiO2 during ventilation with FiO2 - 30%.

The patients will be divided in two sections: Section A are the patients with less than 24 hours mechanical ventilation until weaning start. Section B are the patients with more than 24 hours until weaning start.

The patients in every section will be further divided in two groups. Group 1 will be weaned starting with a PEEP equal with P mean during BiPAP, Group 2 will be weaned starting with a PEEP equal with PEEP during BiPAP.

Further, the weaning will be conducted after an known algorithm. The differences in the oxygenation and decarboxylation will be measured after 30 and 120 Minutes for Group A and after 30, 120, 240, 360 Minutes for Group B.

Eligibility criteria: Inclusion Criteria:

* All Patients that are mechanical ventilated on the intensive care unit.

Exclusion Criteria:

* Patients under 18 years of age
* Patients that where in an other study in the last 30 days
* Patients that are enrolled in other studies
* Pregnant woman
* Nursing mothers
* Existing severe Lung disease
* Existing COPD Gold IV

Primary outcomes:
measure: Changes in the Oxygen Partial Pressure and CO2 Partial Pressure in the arterial blood gas analysis
timeFrame: 30, 60, 90, 120, 360 Minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Osnabrück
country: Germany
facility: Marienhospital Osnabrück
state: Niedersachsen
Study officials:
affiliation: Marienhospital Osnabrück
name: Martin Beiderlinden, P.D. dr. - med.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01218295: Inspiratory Muscle Training With Normocapnic Hyperpnea in Chronic Obstructive Pulmonary Disease (COPD)
Official title: Efficacy of Inspiratory Muscle Training by Means of Spirotiger® in COPD Patients.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: COPD
Keywords: COPD
inspiratory muscles training
Lead sponsor: Università degli Studi di Ferrara
Sponsor class: OTHER
First posted: 2010-10-11
Enrollment: 20
Sex: ALL
Minimum age (years): 40
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Many studies suggest that inspiratory muscles training by means of normocapnic hyperpnea improves exercise tolerance in healthy subjects. No information is available about the use of this training in COPD patients even if other methods (such as threshold loading and resistive loading) have been shown to be effective in terms of Inspiratory Muscle Function, Health-Related Quality of Life and Exercise Tolerance.

This study is designed to evaluate the effects of normocapnic hyperventilation by means of Spirotiger®, an instrument training the respiratory muscles, avoiding hypocapnia (using the methodology of isocapnic hyperpnoea)in COPD patients.


Eligibility criteria: Inclusion Criteria:

* COPD patients. All patients are at stable state, free from an exacerbation from at least 3 months.

Exclusion Criteria:

* COPD patients with a recent history of cardiovascular disease, neurologic disease and other diseases that would interfere with the training.

Primary outcomes:
measure: Exercise Capacity
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Ferrara
country: Italy
facility: Pulmonary Respiratory Unit- University Hospital
Study officials:
affiliation: Università di Ferrara
name: Annalisa Cogo, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01886495: Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children
Official title: High Protein Diet , Adiponectin and Inflammatory Factors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Body Mass Index Quantitative Trait Locus 5 Disorder
Tangier Disease
Lead sponsor: Isfahan University of Medical Sciences
Sponsor class: OTHER
First posted: 2013-06-26
Enrollment: 50
Sex: ALL
Minimum age (years): 6
Maximum age (years): 11
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The investigators aimed to determine the effects of HP diet on adiponectin and inflammatory factors among overweight and obese children.


Eligibility criteria: Inclusion Criteria:

* BMI \> 85th
* age of 6-11 years
* no history of chronic diseases
* taken medications

Exclusion Criteria:

* do not prescribe their diet
* mental retardation

Primary outcomes:
measure: adiponectin (mcg/ml)
timeFrame: 10 weeks
Secondary outcomes:
measure: interlukine 6 (mcg/ml)
timeFrame: 10 weeks
measure: tumor necrosis factor alpha (ng/ml)
timeFrame: 10 weeks
measure: C reactive protein (mcg/ml)
timeFrame: 10 weeks
measure: fibrinogen (mcg/ml)
timeFrame: 10 weeks
Other outcomes:
Locations:
city: Isfahan
country: Iran, Islamic Republic of
facility: Isfahan University of Medical Sciences Leila Azadbakht, Phd
Study officials:
affiliation: Isfahan University of Medical Sciences
name: Leila Azadbakht, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01201395: DPBRN Longitudinal Study of Repaired or Replaced Dental Restorations
Official title: Longitudinal Study of Repaired or Replaced Dental Restorations
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dental Caries
Keywords: Dental Caries
Assessment
dental materials
Lead sponsor: Dental Practice-Based Research Network
Sponsor class: NETWORK
Collaborators: name: National Institute of Dental and Craniofacial Research (NIDCR)
name: HealthPartners Institute
name: Kaiser Permanente
name: Permanente Dental Associates Group, Oregon
name: University of Alabama at Birmingham
name: University of Florida
name: University of Copenhagen
First posted: 2010-09-14
Enrollment: 9813
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The participants directly involved in this study are the particpants who have sought dental treatment in the practitioner-investigators' practices and participated in the DPBRN "Reasons for replacement or repair of dental restorations" study.

Brief summary: The purpose of this study is to assess the quality and expected lifespan of fillings recorded in the DPBRN "Reasons for replacement and repair of dental restorations" study, and the factors affecting how long the fillings last.

Detailed description: The study is an observational follow-up of previously placed dental restorations (fillings)and is conducted during routing dental care visits.

Eligibility criteria: Inclusion Criteria:

* participant in the DPBRN "Reasons for replacement or repair of dental restorations" study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Gainesville
country: United States
facility: University of Florida College of Dentistry
state: Florida
city: Minneapolis
country: United States
facility: Health Partners Dental Group
state: Minnesota
city: Minneapolis
country: United States
facility: Health Partners Research Foundation
state: Minnesota
city: Portland
country: United States
facility: Kaiser Permanente Center for Health Research
state: Oregon
city: Portland
country: United States
facility: Permanente Denrtal Associates
state: Oregon
city: Copenhagen
country: Denmark
facility: University of Copenhagen Royal Dental College
Study officials:
affiliation: University of Florida
name: Valeria V Gordan, DDS, MS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05220995: The Effects of Miminal Stimulation Protocol on Preimplantation Genetic Screening
Official title: The Effects of Miminal Stimulation Protocol on Clinical Outcomes of Advanced Maternal Aged Women With Preimplantation Genetic Screening
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Preimplantation Genetic Screening
Keywords: preimplantation genetic screening
gonadotropin dosage
euploidy rates
Lead sponsor: Nigde Omer Halisdemir University
Sponsor class: OTHER
First posted: 2022-02-02
Enrollment: 200
Sex: FEMALE
Minimum age (years): 38
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 200 advanced maternal aged women

Brief summary: PGS has been the most effective method for embryo selection in IVF cycles. Euploidy rates decrease significantly with advancing maternal age (AMA). The dosage of gonadotropins also may be increased to recruit an adequate number of follicles in AMA women, minimal Stimulation Protocol (MSP) with the new combination of human menopausal gonadotrophin (hMG) and clomiphene citrate (CC) for controlled ovarian hyperstimulation is defined for poor ovarian response women. The aim of this study is to show minimal stimulation protocol affect euploidy and pregnancy rates in preimplatation genetic screening (PGS) cycles with single embryo transfer.


Eligibility criteria: Inclusion Criteria: Advanced maternal aged -

Exclusion Criteria: Severe male factor, endometriosis, and absolute tubal factor were excluded in this study.

-

Primary outcomes:
measure: euploid rates
timeFrame: 3 months
Secondary outcomes:
measure: pregnancy rates
timeFrame: 3 months
Other outcomes:
Locations:
city: Kayseri
country: Turkey
facility: Gokalp Oner
state: Gevher Nesibe
city: Kayseri
country: Turkey
facility: Gokalp Oner
state: Gevher Nesibe
Study officials:
References:
Clinical trial NCT06852495: the Effect of Environmental Factors on Colorectal Cancer Based on Macrogenomes
Official title: A Study of Colorectal Cancer Development and Prognosis Based on Environmental Factors and Macrogenomes
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Colon Cancer
Rectal Cancer
Keywords: Colorectal cancer
Macrogenome
Environmental pollution
air pollution
Lead sponsor: First Affiliated Hospital of Chongqing Medical University
Sponsor class: OTHER
First posted: 2025-02-28
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed with colorectal cancer by pathological biopsy and healthy participants with no history of malignancy were included in the study.

Brief summary: The aim of this study is to investigate the effects of environmental factors, such as air pollution, on the occurrence, development and prognosis of colorectal cancer; to identify metabolic markers specific to colorectal cancer patients, which will provide a basis for early diagnosis, early intervention and individualized treatment; and to comprehensively understand the mechanism of the occurrence and development of colorectal cancer by integrating the data of environmental factors and the macro-genome, and to develop new predictive and therapeutic strategies.


Eligibility criteria: Inclusion Criteria:

* Age ≥18 years old;
* Patients diagnosed with colorectal cancer by pathologic biopsy before surgery;
* Patients did not undergo chemotherapy, radiotherapy, targeted and immunotherapy, etc. before enrollment;
* Willing to participate in the study and sign an informed consent form. Complete clinical data.

Exclusion Criteria:

* Concurrent primary malignant tumor other than colorectal cancer;
* Patients with severe cardiopulmonary insufficiency or other systemic diseases that affect the choice of treatment plan;
* Inappropriate for enrollment as assessed by the investigator;
* Incomplete clinical data.

Primary outcomes:
measure: prognosis
timeFrame: From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months
Secondary outcomes:
measure: Macrogenomic differences
timeFrame: The date of macrogenomic testing, assessed up to 1 week after surgery.
Other outcomes:
Locations:
city: Chongqing
country: China
facility: The First Affiliated Hospital of Chongqing Medical University
state: Chongqing
Study officials:
References: