louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01536912: Medical Marijuana Use in HIV+ Patients: Probability Survey
Official title: Behavioral Economic Analysis of Medical Marijuana Use in HIV+ Patients: Probability Survey
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: HIV Positive
Keywords: HIV positive
Lead sponsor: Wayne State University
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2012-02-22
Enrollment: 218
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Sampling method: NON_PROBABILITY_SAMPLE
Study population: HIV positive

Brief summary: More scientific information is needed about medical marijuana use among HIV positive patients. There is conflicting information about the use of marijuana, use of medical marijuana, and the associations between them and health status/health risk behaviors/health care utilization. In addition, it is not clear whether patients who participate in prospective clinical studies differ from participants who do not participate; if there are differences between those two groups, then this would limit generalizability of knowledge about these issues.

The goal of this project is to describe the use of marijuana among HIV positive patients and its association with health status/health risk behaviors/health care utilization.

Detailed description: Participants will answer questions about marijuana, medical marijuana, and other drug use. We will also ask about health and steps participants take to keep healthy. The study will take up to one hour to complete.

Participants will also be asked to sign a release of information form. This form would allow us to look at medical records at the HIV clinic.

Eligibility criteria: Inclusion Criteria:

* Patients in the HIV clinic
* HIV positive

Exclusion Criteria:

* Lack of english

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Detroit
country: United States
facility: Wayne State University (HIV clinic, Tolan Park Medical Building)
state: Michigan
Study officials:
affiliation: Wayne State University
name: Mark Greenwald, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06764212: Investigation of the Diagnostic Efficacy of the M-Mode Ultrasonography in the Diagnosis of Myofascial Pain Syndrome
Official title: Investigation of the Diagnostic Efficacy of the Amount of Fascial Sliding Measured by M-Mode Ultrasonography in the Diagnosis of Myofascial Pain Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myofascial Pain Syndromes
Keywords: pain
ultrasound
Lead sponsor: Bursa Yüksek İhtisas Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2025-01-08
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Myofascial pain syndrome, or MPS, is a prevalent musculoskeletal disorder, which is characterised by the presence of muscle pain and tenderness. The inflammation and microtrauma that are the consequence result in adhesions between the fascial layers. It has been reported that these adhesions prevent the fasciae from sliding over each other and contribute to pain.

Detailed description: The rhomboid and trapezius muscles are commonly involved in MPS, which often affects the upper extremity.

This study hypothesized that muscle sliding decreases in patients with MPS. To this end, the investigators measured the amount of fascial sliding of the trapezius muscle in healthy volunteers and patients with MPS using M-mode ultrasound and a software-assisted program to investigate the differences and diagnostic value.

Eligibility criteria: Inclusion Criteria:

* At least one active trigger point
* Moderate back pain lasting more than 3 months
* Diagnosis of MPS according to Travell and Simons diagnostic criteria
* Healthy volunteers

Exclusion Criteria:

* cervical disc disease
* Fibromyalgia
* Central or peripheral nerve disease
* Shoulder joint disease
* Malignancy
* Rheumatic disease
* those who had been treated for MPS within 6 months

Primary outcomes:
measure: m-mode
timeFrame: 30 minutes
Secondary outcomes:
measure: Trapezius and rhomboid muscle
timeFrame: 30 minutes
measure: vas
timeFrame: baseline
measure: NPDS
timeFrame: baseline
measure: sf-12
timeFrame: baseline
Other outcomes:
Locations:
city: Nilüfer
country: Turkey
facility: Burcu Metin Ökmen
state: Bursa
city: Bursa
country: Turkey
facility: Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi
Study officials:
References:
Clinical trial NCT03411512: Congenital Heart Defects and NIRS
Official title: Tissue Oxygenation in Newborns With Congenital Heart Defects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart Defects, Congenital
Keywords: congenital heart defects
near-infrared spectroscopy
newborn
tissue oxygenation
Lead sponsor: University Medical Centre Ljubljana
Sponsor class: OTHER
First posted: 2018-01-26
Enrollment: 65
Sex: ALL
Minimum age (years): 1
Maximum age (years): 4
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: term newborns

Brief summary: Congenital Heart Defects and NIRS

Detailed description: Brain, kidney and intestinal tissue oxygenation in newborns with congenital heart defects assessed by near-infrared spectroscopy.

Eligibility criteria: Inclusion Criteria:

Investigators included term newborns with critical structural CHD (of different types) who required surgical or transcatheter procedure in the first year of life. CHD were diagnosed by pediatric cardiologist by clinical examination and echocardiography.

Exclusion Criteria:

The exclusion criteria were pulmonary or neurological disease, perinatal asphyxia, acute illness, prematurity and congenital abnormality other than CHD.

Primary outcomes:
measure: rSO2
timeFrame: RSO2 values were obtained after 30 minute calm down period to enable stable recordings on each channel by averaging five minutes recorded values.
Secondary outcomes:
Other outcomes:
Locations:
city: Ljubljana
country: Slovenia
facility: University Medical Centre Ljubljana
Study officials:
References:
Clinical trial NCT01237912: European Exposure Study
Official title: A European, Multi-centre Study to Determine the Exposure of Adult Smokers and Non-smokers to Cigarette Smoke Constituents
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Smoking
Lead sponsor: Philip Morris Products S.A.
Sponsor class: INDUSTRY
First posted: 2010-11-10
Enrollment: 1667
Sex: ALL
Minimum age (years): 21
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male or female 21 years of age or older with a stable health status as determined by the Investigator and who were able to understand the subject information and to comply with the study procedures and study schedule.

Brief summary: The current study was designed to determine the exposure of adult smokers and non-smokers to cigarette smoke constituents through evaluation of selected biomarkers of exposure.

Detailed description: The purpose of the study was to provide a greater knowledge about human exposure to cigarette smoke constituents by evaluating selected biomarkers of exposure in smokers and non-smokers. This was an observational, parallel-group study to be conducted at multiple centres in the UK, Germany, and Switzerland. It was planned to enrol sufficient subjects such that at least 1440 subjects complete the study.

Eligibility criteria: Inclusion Criteria:

Smokers: Subjects who smoked commercial cigarettes exclusively (less than or equal to 10 mg ISO tar yield in Germany and the UK; less than or equal to 12 mg ISO tar yield in Switzerland) with a regular consumption of at least 1 cigarette per day over the last 12 months without change in brand over the previous 3 months.

or

Non-smokers: Subjects who did not smoke commercial cigarettes, hand-rolled cigarettes, cigars, pipes, bidis, and did not use other nicotine-containing products (patch, gum, lozenges etc.) within 1 year prior to Visit 1 and throughout the study duration.

Exclusion Criteria:

* Female subjects with child-bearing potential were to be excluded if

  1. Subject was pregnant (or did not have negative pregnancy tests) or breast-feeding
  2. Subject did not agree to use an acceptable method of contraception

Primary outcomes:
measure: To determine the exposure of adult smokers and non-smokers to cigarette smoke constituents
timeFrame: 2 consecutive visits within 14 days
Secondary outcomes:
Other outcomes:
Locations:
city: Belfast
country: United Kingdom
facility: Stephen Smith
state: Northern Ireland
Study officials:
affiliation: Celerion, 22-24 Lisburn Road, Belfast, BT9 6AD, Northern Ireland
name: Stephen Smith
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lindner D, Smith S, Leroy CM, Tricker AR. Comparison of exposure to selected cigarette smoke constituents in adult smokers and nonsmokers in a European, multicenter, observational study. Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1524-36. doi: 10.1158/1055-9965.EPI-10-1186. Epub 2011 May 25.
Clinical trial NCT03399812: Breakfast and Metabolism in Men
Official title: The Effect of Breakfast on Energy Metabolism, Appetite, and Food Intake in Men
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging
Lead sponsor: University of Arkansas, Fayetteville
Sponsor class: OTHER
First posted: 2018-01-16
Enrollment: 33
Sex: MALE
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study will determine the short-term postprandial effects of protein source at breakfast on energy metabolism, markers of metabolic health, appetite, and food intake and young and older men.


Eligibility criteria: Inclusion Criteria:

* Male
* No medication
* Athlete (elite or professional)

Exclusion Criteria:

* Diet-related conditions
* Food allergies
* Does not regularly consume protein supplements
* Claustrophobic
* Underweight

Primary outcomes:
measure: Energy expenditure
timeFrame: Time frame is every 30 minutes for four hours following intervention.
measure: Appetite
timeFrame: Time frame is every 30 minutes for four hours following intervention.
Secondary outcomes:
measure: 24-hour food intake
timeFrame: Food intake will be recorded for one day.
Other outcomes:
measure: Appetite biomarkers
timeFrame: Time frame is every 30 minutes for four hours following intervention.
Locations:
city: Fayetteville
country: United States
facility: University of Arkansas
state: Arkansas
Study officials:
affiliation: University of Arkansas, Fayetteville
name: Jamie Baum
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hawley AL, Gbur E, Tacinelli AM, Walker S, Murphy A, Burgess R, Baum JI. The Short-Term Effect of Whey Compared with Pea Protein on Appetite, Food Intake, and Energy Expenditure in Young and Older Men. Curr Dev Nutr. 2020 Jan 22;4(2):nzaa009. doi: 10.1093/cdn/nzaa009. eCollection 2020 Feb.
Clinical trial NCT03415412: Clinical Evaluation of Three Different Universal Adhesives in Non-carious Cervical Lesions
Official title: Clinical Evaluation of Three Different Universal Adhesives and a Universal Flowable Composite for Restoration of Non-carious Cervical Lesions
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Tooth Diseases
Keywords: non-caries cervical lesion
universal adhesives
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2018-01-30
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this randomized, controlled prospective clinical trial is to evaluate and compare the performances of three different universal adhesives using a flowable universal composite resin in the restoration of non-caries cervical lesions over 48-month period.Participants over 18 will be included to the study. Oral hygiene instructions will be given before procedures. All the lesions will be restored by the same clinician who will not participate to the selection of patients for eligibility. Each patient will receive at least three restorations and randomization will be applied using a table of random numbers. All lesions will be cleaned before restoring. Adhesive procedures and restorations will be placed according to manufacturers' recommandation.

The flowable universal composite resin will be placed in bulk and light-cured for 40 seconds. The restorations will be contoured and polished with Optidisc discs (Kerr Coorporation, Orange, CA, USA).

Patients will be recalled at baseline and will be recalled at control periods after placement.


Eligibility criteria: Inclusion Criteria:

* 18 years old with 20 teeth under occlusion. They will be required to have at least three NCCLs needed restoration in different teeth. All the NCCLs selected were in similar sizes varying between 1-3 mm.

Exclusion Criteria:

* Patients with severe periodontal disease, rampant, uncontrolled caries, xerostomia, serious medical problems preventing them from attending review visits, poor gingival health, heavy bruxism and removable partial dentures will not be included in the present study. Also, participiants will be excluded, if they are undergoing bleaching treatment or orthodontic treatment.

Primary outcomes:
measure: Clinical performances of different universal adhesives
timeFrame: Two years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Oz FD, Ozturk C, Soleimani R, Gurgan S. Sixty-month follow up of three different universal adhesives used with a highly-filled flowable resin composite in the restoration of non-carious cervical lesion. Clin Oral Investig. 2022 Aug;26(8):5377-5387. doi: 10.1007/s00784-022-04505-x. Epub 2022 Apr 27.
Clinical trial NCT03757312: A Pilot Study of Optic Nerve Ultrasound Following Cardiopulmonary Bypass
Official title: A Pilot Study of Optic Nerve Ultrasound Following Cardiopulmonary Bypass
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Congenital Heart Disease
Congenital Heart Defect
Keywords: cardiopulmonary bypass
Lead sponsor: Nationwide Children's Hospital
Sponsor class: OTHER
First posted: 2018-11-28
Enrollment: 14
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of the proposed study is to evaluate the incidence of subtle increases in intracranial pressure (ICP) following cardiopulmonary bypass (CPB) using optic nerve sheath diameter (ONSD), measured by non-invasive ultrasound. As direct measurements of ICP are not feasible following CPB, ONSD will be used as a correlate of ICP. ONSD has been shown to be effective in the ICU and emergency room setting for detecting increased ICP and is an accepted standard for such measurements. The primary hypothesis is that changes in ICP occur following CPB without clinically appreciable signs and symptoms. These changes in ICP will be reflected by changes in ONSD. If there is a significant incidence of sub-clinical cerebral edema and increased ICP postoperatively, these findings may impact postoperative hemodynamic and ventilation goals and techniques.


Eligibility criteria: Inclusion Criteria:

* Patients less than 18 years of age undergoing cardiac bypass.

Exclusion Criteria:

* None

Primary outcomes:
measure: Optic Nerve Sheath Diameter
timeFrame: Day of surgery
Secondary outcomes:
measure: Optic Nerve Sheath Diameter: Short Versus Long Cardiopulmonary Bypass (CPB) Time
timeFrame: Day of surgery
Other outcomes:
Locations:
city: Columbus
country: United States
facility: Nationwide Children's Hospital
state: Ohio
Study officials:
affiliation: Nationwide Children's Hospital
name: Marco Corridore, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00727012: Multicenter International Trial Ring AnnulopLasty
Official title: Multicenter International Trial Ring AnnulopLasty
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mitral Valve Insufficiency
Keywords: mitral valve
heart valve
valve repair
valve disorder
valve disease
cardiac surgery
Lead sponsor: Abbott Medical Devices
Sponsor class: INDUSTRY
First posted: 2008-08-01
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This clinical study is a multicenter, prospective non-randomized observational study without concurrent or matched controls in which 150 patients receiving an SJM® Rigid Saddle Ring will be included. The primary objective of the study is to demonstrate the effectiveness of the SJM® Rigid Saddle Ring when used in mitral valve repair procedures.


Eligibility criteria: Inclusion Criteria:

* Patient requiring a mitral valve repair due to mitral degenerative or functional disease (Note: Patients that underwent concomitant procedures, e.g. coronary artery bypass grafting, are eligible for this study);
* Patient (or legal guardian) has signed a study specific informed consent form agreeing to the data collection and follow-up requirements;
* Patients are at least 18 years old.

Exclusion Criteria:

* Patient requires replacement of the aortic, tricuspid or pulmonary valve or has a pre-existing prosthetic valve;
* Patient is pregnant or nursing;
* Patient has active endocarditis;
* Patient is actively participating in another study of an investigational drug or device;
* Patients unavailable to follow-up visit (abroad residents, patients affected by neurological disorders...);
* Patients who are intravenous drug abusers, alcohol abusers, prison inmates or unable to give informed consent;
* Patients with a major non-cardiac evolving disease;
* Patients with a life expectancy less than 1 year;
* Patients are known to be noncompliant or are unlikely to complete the study;
* Any case in which mitral annuloplasty rings are not indicated;

Primary outcomes:
measure: Change in ERO (Effective Regurgitant Orifice) in cm2 calculated with PISA method at 6 months and at patient discharge compared to baseline (pre-operative).
timeFrame: 6 months
measure: NYHA class
timeFrame: 6 months
Secondary outcomes:
measure: adverse events rates
timeFrame: 6 months
Other outcomes:
Locations:
city: Heidelberg
country: Germany
facility: University of Heidelberg
Study officials:
affiliation: Heidelberg University
name: Raffaele De Simone, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05960812: Skillful Neglect Vs Repair For Subscapularis Tear Associated With Posterosuperior Cuff Tears Repair.
Official title: Skillful Neglect Vs Repair For Upper Border Subscapularis Tear Associated With Posterosuperior Cuff Tears Repair In Non-Athletes: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Subscapularis Muscle Strain
Keywords: Rotator cuff tear
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2023-07-27
Enrollment: 30
Sex: ALL
Minimum age (years): 40
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare functional outcomes of Skillful Neglect \& arthroscopic repair of upper border subscapularis tear in La fosse type 1 and type 2 with biceps tenotomy in non-athletes,30 shoulders subdivided randomly into 2 groups, 15 patients in group 1 (patient treated by skillful neglect with biceps tenotomy) and 15 patients in group 2 (patients treated by arthroscopic repair with biceps tenotomy)

Detailed description: patients are randomized chosen then a shoulder arthroscope is done for all patients with biceps tenotomy but in group1 the investigators are neglecting the upper border tears and in group 2 the investigators are repairing upper border tears with anchors then after the procedure is completed the investigators will follow up by ASES score

Eligibility criteria: Inclusion Criteria:

* Patients with combined upper subscapularis border tear in Lafosse type 1 and type 2.

Exclusion Criteria:

* Glenohumeral arthritis.
* Patients with other intra-articular pathology like SLAP lesions.
* Neural damage (Brachial plexus injury).
* Revision cases.
* Patient with subscapularis border tear type 3, type 4, and type 5.

Primary outcomes:
measure: american shoulder elbow score
timeFrame: after 6months and 12 months
Secondary outcomes:
measure: Visual analogue score
timeFrame: Post operative 6months and 12 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University Hospitals
Study officials:
affiliation: Ain Shams University
name: mohamed as abdallah, master
role: PRINCIPAL_INVESTIGATOR
affiliation: Ain Shams University
name: Amr Mo Abdelhady
role: STUDY_CHAIR
affiliation: Ain Shams University
name: Maged Mo Samy
role: STUDY_DIRECTOR
affiliation: Ain Shams University
name: Mohamed Ha Sobhy
role: STUDY_DIRECTOR
affiliation: Ain Shams University
name: Yahia Mo Haroun
role: STUDY_DIRECTOR
References: