Clinical trial NCT06875310: A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
Official title: A Randomized, Double-Blind, Phase 3 Trial of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated, Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Carcinoma, Non-Small-Cell Lung
Keywords: Immunotherapy
KRAS
KRAS G12C
Targeted therapy
Lead sponsor: Mirati Therapeutics Inc.
Sponsor class: INDUSTRY
First posted: 2025-03-13
Enrollment: 630
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation


Eligibility criteria: Inclusion Criteria:

* Histologically or cytologically confirmed diagnosis of non-squamous NSCLC with evidence of KRAS G12C mutation via tumor tissue and/or circulating tumor deoxyribonucleic acid (ctDNA).
* Locally advanced or metastatic disease.
* Measurable disease via computed tomography (CT) or magnetic resonance imaging (MRI) per RECIST v1.1 criteria of at least 1 lesion.
* No prior systemic anti-cancer therapy given for advanced or metastatic disease.
* Not a candidate for definitive therapy (eg, chemoradiation or complete surgical resection).
* Participants with brain metastases are eligible for enrollment, including those with untreated brain metastases. Brain metastases must be asymptomatic and not in need of immediate local therapy. Any untreated brain metastases must be ≤ 20 mm in diameter.
* Any PD-L1 expression (0 to 100%) as determined by VENTANA PD-L1 (SP263) assay, Agilent PD-L1 IHC 22C3 pharmDx, or Agilent PD-L1 IHC 28-8 pharmDx.

Exclusion Criteria:

* Participants with an active, known, prior documented, or suspected autoimmune or inflammatory disease.
* Uncontrolled or significant cardiovascular conditions within 6 months prior to enrollment.
* Inadequate bone marrow or liver function or electrocardiogram (ECG) abnormalities.
* Ongoing treatment with concomitant medication known to cause prolonged QTc interval and that cannot be switched to alternative treatment prior to study entry.
* Treatment targeting KRAS G12C mutation (eg, sotorasib, adagrasib) in any setting.
* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcomes:
measure: Progression Free Survival (PFS) as Assessed per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by Blinded Independent Central Review (BICR)
timeFrame: Up to 7 years
measure: Overall Survival (OS)
timeFrame: Up to 7 years
Secondary outcomes:
measure: Overall Response (OR) as Assessed per RECIST v1.1 by BICR
timeFrame: Up to 7 years
measure: Duration of Response (DOR) as Assessed per RECIST 1.1 by BICR
timeFrame: Up to 7 years
measure: PFS as Assessed per RECIST v1.1 by Investigator
timeFrame: Up to 7 years
measure: Number of Participants With Adverse Events (AEs)
timeFrame: Up to 90 days from last dose
measure: Number of Participants With Serious Adverse Events (SAEs)
timeFrame: Up to 90 days from last dose
measure: Number of Participants With AEs Leading to Dose Interruption
timeFrame: Up to 90 days from last dose
measure: Number of Participants With AEs Leading to Dose Reduction
timeFrame: Up to 90 days from last dose
measure: Number of Participants With AEs Leading to Treatment Discontinuation
timeFrame: Up to 90 days from last dose
measure: Number of Deaths
timeFrame: Up to 90 days from last dose
measure: Time to Definitive Deterioration by Non-Small Cell Lung Cancer-Symptom Assessment Questionnaire (NSCLC-SAQ) Total Score
timeFrame: Up to 7 years
measure: Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-30) Scale/item Score
timeFrame: Up to 90 days from last dose
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Local Institution - 0347
state: Alabama
city: Fullerton
country: United States
facility: Local Institution - 0581
state: California
city: Long Beach
country: United States
facility: Local Institution - 0202
state: California
city: Newport Beach
country: United States
facility: Local Institution - 0643
state: California
city: Orange
country: United States
facility: Local Institution - 0666
state: California
city: Santa Barbara
country: United States
facility: Local Institution - 0623
state: California
city: Denver
country: United States
facility: Local Institution - 0442
state: Colorado
city: Gainesville
country: United States
facility: Local Institution - 0651
state: Florida
city: Palm Bay
country: United States
facility: Local Institution - 0621
state: Florida
city: Tamarac
country: United States
facility: Local Institution - 0377
state: Florida
city: Tampa
country: United States
facility: Local Institution - 0647
state: Florida
city: Fort Eisenhower
country: United States
facility: Local Institution - 0392
state: Georgia
city: Marietta
country: United States
facility: Local Institution - 0031
state: Georgia
city: Arlington Heights
country: United States
facility: Local Institution - 0665
state: Illinois
city: Munster
country: United States
facility: Local Institution - 0423
state: Indiana
city: Edgewood
country: United States
facility: Local Institution - 0366
state: Kentucky
city: Louisville
country: United States
facility: Local Institution - 0566
state: Kentucky
city: Shreveport
country: United States
facility: Local Institution - 0644
state: Louisiana
city: Columbia
country: United States
facility: Local Institution - 0385
state: Maryland
city: Boston
country: United States
facility: Local Institution - 0019
state: Massachusetts
city: Worcester
country: United States
facility: Local Institution - 0437
state: Massachusetts
city: White Plains
country: United States
facility: Local Institution - 0618
state: New York
city: Asheville
country: United States
facility: Local Institution - 0624
state: North Carolina
city: Salisbury
country: United States
facility: Local Institution - 0672
state: North Carolina
city: Columbus
country: United States
facility: Local Institution - 0620
state: Ohio
city: York
country: United States
facility: Local Institution - 0657
state: Pennsylvania
city: Greenville
country: United States
facility: Local Institution - 0658
state: South Carolina
city: Laredo
country: United States
facility: Local Institution - 0652
state: Texas
city: San Antonio
country: United States
facility: Local Institution - 0622
state: Texas
city: Ciudad Autónoma de Buenos Aires
country: Argentina
facility: Local Institution - 0575
state: Buenos Aires
city: Ciudad de Buenos Aires
country: Argentina
facility: IDIM - Instituto de Investigaciones Metabólicas
state: Buenos Aires
city: Pilar
country: Argentina
facility: Local Institution - 0584
state: Buenos Aires
city: ABB
country: Argentina
facility: Hospital Italiano de Buenos Aires
state: Ciudad Autónoma De Buenos Aires
city: Buenos Aires
country: Argentina
facility: Local Institution - 0571
state: Ciudad Autónoma De Buenos Aires
city: Caba
country: Argentina
facility: Local Institution - 0573
state: Ciudad Autónoma De Buenos Aires
city: Rosario
country: Argentina
facility: Sanatorio Plaza
state: Santa Fe
city: Canberra
country: Australia
facility: Local Institution - 0126
state: Australian Capital Territory
city: North Tamworth
country: Australia
facility: Tamworth Hospital
state: New South Wales
city: Orange
country: Australia
facility: Orange Hospital
state: New South Wales
city: Brisbane
country: Australia
facility: Local Institution - 0127
state: Queensland
city: Elizabeth Vale
country: Australia
facility: Lyell McEwin Hospital
state: South Australia
city: Frankston
country: Australia
facility: Frankston Hospital
state: Victoria
city: Melbourne
country: Australia
facility: Local Institution - 0121
state: Victoria
city: Traralgon
country: Australia
facility: Local Institution - 0160
state: Victoria
city: Joondalup
country: Australia
facility: Joondalup Health Campus
state: Western Australia
city: Wels
country: Austria
facility: Local Institution - 0532
state: Oberösterreich
city: Graz
country: Austria
facility: Local Institution - 0539
state: Steiermark
city: Linz
country: Austria
facility: Local Institution - 0530
city: Wien
country: Austria
facility: Local Institution - 0533
city: Wien
country: Austria
facility: Local Institution - 0673
city: Brussels
country: Belgium
facility: Local Institution - 0114
state: Bruxelles-Capitale, Région De
city: Brussels
country: Belgium
facility: Local Institution - 0113
state: Bruxelles-Capitale, Région De
city: Hasselt
country: Belgium
facility: Local Institution - 0215
state: Limburg
city: Gent
country: Belgium
facility: Local Institution - 0216
state: Oost-Vlaanderen
city: Leuven
country: Belgium
facility: Local Institution - 0107
state: Vlaams-Brabant
city: Liège
country: Belgium
facility: Local Institution - 0109
city: Salvador
country: Brazil
facility: Local Institution - 0257
state: Bahia
city: Vitória
country: Brazil
facility: Local Institution - 0242
state: Espírito Santo
city: Belo Horizonte
country: Brazil
facility: Local Institution - 0244
state: Minas Gerais
city: Ijui
country: Brazil
facility: Local Institution - 0235
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Local Institution - 0233
state: Rio Grande Do Sul
city: Santa Cruz do Sul
country: Brazil
facility: Local Institution - 0238
state: Rio Grande Do Sul
city: Porto Velho
country: Brazil
facility: Local Institution - 0243
state: Rondonia
city: Blumenau
country: Brazil
facility: Local Institution - 0237
state: Santa Catarina
city: Itajaí
country: Brazil
facility: Local Institution - 0245
state: Santa Catarina
city: Barretos
country: Brazil
facility: Local Institution - 0240
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Local Institution - 0254
state: São Paulo
city: São Carlos
country: Brazil
facility: Local Institution - 0241
state: São Paulo
city: São José do Rio Preto
country: Brazil
facility: Local Institution - 0239
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: Local Institution - 0236
city: São Paulo
country: Brazil
facility: Local Institution - 0258
city: Panagyurishte
country: Bulgaria
facility: Local Institution - 0629
state: Pazardzhik
city: Sofia
country: Bulgaria
facility: Local Institution - 0628
state: Sofia (stolitsa)
city: Ruse
country: Bulgaria
facility: Local Institution - 0627
city: Stara Zagora
country: Bulgaria
facility: Local Institution - 0635
city: Halifax
country: Canada
facility: Local Institution - 0074
state: Nova Scotia
city: Montreal
country: Canada
facility: Local Institution - 0559
state: Quebec
city: Recoleta
country: Chile
facility: Bradfordhill
state: Región Metropolitana De Santiago
city: Santiago
country: Chile
facility: FALP
state: Región Metropolitana De Santiago
city: Bengbu
country: China
facility: Local Institution - 0482
state: Anhui
city: Hefei
country: China
facility: Local Institution - 0475
state: Anhui
city: Beijing
country: China
facility: Local Institution - 0355
state: Beijing
city: Beijing
country: China
facility: Local Institution - 0491
state: Beijing
city: Beijing
country: China
facility: Local Institution - 0397
state: Beijing
city: Chongqing
country: China
facility: Local Institution - 0490
state: Chongqing
city: Fuzhou Fujian
country: China
facility: Local Institution - 0362
state: Fujian
city: Xiamen
country: China
facility: Local Institution - 0383
state: Fujian
city: Guangzhou
country: China
facility: Local Institution - 0469
state: Guangdong
city: Guangzhou
country: China
facility: Local Institution - 0625
state: Guangdong
city: Shantou
country: China
facility: Local Institution - 0356
state: Guangdong
city: Shenzhen
country: China
facility: Local Institution - 0461
state: Guangdong
city: Shenzhen
country: China
facility: Local Institution - 0352
state: Guangdong
city: Nanning
country: China
facility: Local Institution - 0464
state: Guangxi
city: Shijiazhuang
country: China
facility: Local Institution - 0472
state: Hebei
city: Harbin
country: China
facility: Local Institution - 0465
state: Heilongjiang
city: Nanyang
country: China
facility: Local Institution - 0626
state: Henan
city: Xinxiang
country: China
facility: Local Institution - 0494
state: Henan
city: Wuhan
country: China
facility: Local Institution - 0373
state: Hubei
city: Changsha
country: China
facility: Local Institution - 0398
state: Hunan
city: Nanjing
country: China
facility: Local Institution - 0371
state: Jiangsu
city: Suzhou
country: China
facility: Local Institution - 0382
state: Jiangsu
city: Yangzhou
country: China
facility: Local Institution - 0378
state: Jiangsu
city: Nanchang
country: China
facility: Local Institution - 0467
state: Jiangxi
city: Changchun
country: China
facility: Local Institution - 0483
state: Jilin
city: Shenyang
country: China
facility: Local Institution - 0473
state: Liaoning
city: Shenyang
country: China
facility: Local Institution - 0479
state: Liaoning
city: Shenyang
country: China
facility: Local Institution - 0493
state: Liaoning
city: Jinan
country: China
facility: Local Institution - 0474
state: Shandong
city: Linyi
country: China
facility: Local Institution - 0359
state: Shandong
city: Shanghai
country: China
facility: Local Institution - 0470
state: Shanghai
city: Shanghai
country: China
facility: Local Institution - 0381
state: Shanghai
city: Taiyuan
country: China
facility: Local Institution - 0353
state: Shanxi
city: Cheng Du
country: China
facility: Local Institution - 0384
state: Sichuan
city: Chengdu
country: China
facility: Local Institution - 0667
state: Sichuan
city: Tianjin
country: China
facility: Local Institution - 0460
state: Tianjin
city: Hangzhou
country: China
facility: Local Institution - 0462
state: Zhejiang
city: Hangzhou
country: China
facility: Local Institution - 0492
state: Zhejiang
city: Hangzhou
country: China
facility: Local Institution - 0463
state: Zhejiang
city: Linhai
country: China
facility: Local Institution - 0374
state: Zhejiang
city: Shanghai
country: China
facility: Local Institution - 0354
city: Medellín
country: Colombia
facility: Local Institution - 0580
state: Antioquia
city: Rionegro
country: Colombia
facility: Local Institution - 0171
state: Antioquia
city: Puerto Colombia
country: Colombia
facility: Local Institution - 0191
state: Atlántico
city: Valledupar
country: Colombia
facility: Local Institution - 0253
state: Cesar
city: Montería
country: Colombia
facility: Local Institution - 0167
state: COR
city: Bogota
country: Colombia
facility: Local Institution - 0671
state: Cundinamarca
city: Bogotá
country: Colombia
facility: Local Institution - 0189
state: Distrito Capital De Bogotá
city: Floridablanca
country: Colombia
facility: Local Institution - 0170
state: Santander
city: Cali
country: Colombia
facility: Local Institution - 0173
state: Valle Del Cauca
city: Dubrovnik
country: Croatia
facility: Local Institution - 0619
state: Dubrovačko-neretvanska Županija
city: Rijeka
country: Croatia
facility: Local Institution - 0664
state: Primorsko-goranska Županija
city: Split
country: Croatia
facility: Local Institution - 0639
state: Splitsko-dalmatinska Županija
city: Osijek
country: Croatia
facility: Local Institution - 0567
city: Zagreb
country: Croatia
facility: Local Institution - 0585
city: Mulhouse
country: France
facility: Local Institution - 0159
state: Alsace
city: Caen
country: France
facility: Local Institution - 0296
state: Calvados
city: Dijon
country: France
facility: Local Institution - 0605
state: Côte-d'Or
city: Brest
country: France
facility: Local Institution - 0512
state: Finistère
city: Montpellier
country: France
facility: Local Institution - 0558
state: Hérault
city: La Tronche
country: France
facility: Local Institution - 0220
state: Isère
city: Saint-Herblain
country: France
facility: Local Institution - 0139
state: Loire-Atlantique
city: Angers
country: France
facility: Local Institution - 0560
state: Maine-et-Loire
city: Vandoeuvre lès Nancy
country: France
facility: Local Institution - 0589
state: Meurthe-et-Moselle
city: Marseille
country: France
facility: Local Institution - 0636
state: Provence-Alpes-Côte-d'Azur
city: Amiens
country: France
facility: Local Institution - 0552
state: Somme
city: Villejuif
country: France
facility: Local Institution - 0213
state: Val-de-Marne
city: Clermont-Ferrand
country: France
facility: Local Institution - 0134
city: Limoges
country: France
facility: Local Institution - 0604
city: Marseille
country: France
facility: Local Institution - 0164
city: Paris
country: France
facility: Local Institution - 0133
city: Paris
country: France
facility: Local Institution - 0158
city: Boulogne-Billancourt
country: France
facility: Local Institution - 0513
state: Île-de-France
city: Esslingen
country: Germany
facility: Local Institution - 0534
state: Baden-Württemberg
city: Ulm
country: Germany
facility: Local Institution - 0670
state: Baden-Württemberg
city: München
country: Germany
facility: Local Institution - 0557
state: Bayern
city: Frankfurt
country: Germany
facility: Local Institution - 0518
state: Hessen
city: Gießen
country: Germany
facility: Local Institution - 0535
state: Hessen
city: Hannover
country: Germany
facility: Local Institution - 0520
state: Niedersachsen
city: Oldenburg
country: Germany
facility: Local Institution - 0527
state: Niedersachsen
city: Herne
country: Germany
facility: Local Institution - 0603
state: Nordrhein-Westfalen
city: Köln
country: Germany
facility: Local Institution - 0523
state: Nordrhein-Westfalen
city: Halle
country: Germany
facility: Local Institution - 0522
state: Sachsen-Anhalt
city: Flensburg
country: Germany
facility: Local Institution - 0521
state: Schleswig-Holstein
city: Gera
country: Germany
facility: Local Institution - 0524
state: Thüringen
city: Jena
country: Germany
facility: Local Institution - 0551
state: Thüringen
city: Berlin
country: Germany
facility: Local Institution - 0526
city: Berlin
country: Germany
facility: Local Institution - 0537
city: Hemer
country: Germany
facility: Local Institution - 0528
city: Stuttgart
country: Germany
facility: Local Institution - 0517
city: Wuerzburg
country: Germany
facility: Local Institution - 0525
city: Athens
country: Greece
facility: Local Institution - 0608
state: Attikí
city: Athens
country: Greece
facility: Local Institution - 0612
state: Attikí
city: Larissa
country: Greece
facility: Local Institution - 0609
state: Thessalía
city: Hksar
country: Hong Kong
facility: Local Institution - 0379
city: Hksar
country: Hong Kong
facility: Local Institution - 0466
city: Gyor
country: Hungary
facility: Local Institution - 0601
state: Győr-Moson-Sopron
city: Gyöngyös
country: Hungary
facility: Local Institution - 0144
state: Heves
city: Tatabánya
country: Hungary
facility: Local Institution - 0157
state: Komárom-Esztergom
city: Kaposvár
country: Hungary
facility: Local Institution - 0593
state: Somogy
city: Farkasgyepu
country: Hungary
facility: Local Institution - 0143
state: Veszprém
city: Budapest
country: Hungary
facility: Local Institution - 0151
city: Budapest
country: Hungary
facility: Local Institution - 0140
city: Visakhapatnam
country: India
facility: Local Institution - 0222
state: Andhra Pradesh
city: New Delhi
country: India
facility: Local Institution - 0312
state: Delhi
city: New Delhi
country: India
facility: Local Institution - 0511
state: Delhi
city: New Delhi
country: India
facility: Local Institution - 0135
state: Delhi
city: Ahmedabad
country: India
facility: Local Institution - 0136
state: Gujarat
city: Ahmedabad
country: India
facility: Local Institution - 0230
state: Gujarat
city: Thiruvananthapuram
country: India
facility: Local Institution - 0155
state: Kerala
city: Mumbai
country: India
facility: Local Institution - 0154
state: Maharashtra
city: Bhubaneswar
country: India
facility: Local Institution - 0226
state: Odisha
city: Madurai
country: India
facility: Local Institution - 0224
state: Tamil Nadu
city: Hyderabad
country: India
facility: Local Institution - 0663
state: Telangana
city: Varanasi
country: India
facility: Local Institution - 0153
state: Uttar Pradesh
city: Howrah
country: India
facility: Local Institution - 0161
state: West Bengal
city: Kolkata
country: India
facility: Local Institution - 0221
state: West Bengal
city: Hyderabad
country: India
facility: Local Institution - 0661
city: Cork
country: Ireland
facility: Local Institution - 0102
city: Dublin
country: Ireland
facility: Local Institution - 0476
city: Dublin
country: Ireland
facility: Local Institution - 0101
city: Dublin
country: Ireland
facility: Local Institution - 0100
city: Dublin
country: Ireland
facility: Local Institution - 0106
city: Petah Tikva
country: Israel
facility: Local Institution - 0597
state: HaMerkaz
city: Ramat Gan
country: Israel
facility: Local Institution - 0596
state: HaMerkaz
city: Zerifin
country: Israel
facility: Local Institution - 0600
state: HaMerkaz
city: Jerusalem
country: Israel
facility: Local Institution - 0544
state: Yerushalayim
city: Haifa
country: Israel
facility: Local Institution - 0613
state: Ḥeifā
city: Meldola
country: Italy
facility: Local Institution - 0067
state: Emilia-Romagna
city: Naples
country: Italy
facility: Local Institution - 0066
state: Napoli
city: Orbassano
country: Italy
facility: Local Institution - 0070
state: Piemonte
city: Bari
country: Italy
facility: Local Institution - 0071
state: Puglia
city: Rome
country: Italy
facility: Local Institution - 0068
state: Roma
city: Firenze
country: Italy
facility: Local Institution - 0069
state: Toscana
city: Genova
country: Italy
facility: Local Institution - 0588
city: Padova
country: Italy
facility: Local Institution - 0073
city: Parma
country: Italy
facility: Local Institution - 0156
city: Pavia
country: Italy
facility: Local Institution - 0543
city: Varese
country: Italy
facility: Local Institution - 0556
city: Nagoya
country: Japan
facility: Local Institution - 0607
state: Aichi
city: Nagoya
country: Japan
facility: Local Institution - 0305
state: Aichi
city: Sapporo
country: Japan
facility: Local Institution - 0298
state: Hokkaido
city: Kanazawa
country: Japan
facility: Local Institution - 0304
state: Ishikawa
city: Sagamihara
country: Japan
facility: Local Institution - 0302
state: Kanagawa
city: Yokohama
country: Japan
facility: Local Institution - 0369
state: Kanagawa
city: Sendai
country: Japan
facility: Local Institution - 0301
state: Miyagi
city: Kashihara
country: Japan
facility: Local Institution - 0306
state: Nara
city: Kurashiki
country: Japan
facility: Local Institution - 0368
state: Okayama
city: Hirakata
country: Japan
facility: Local Institution - 0642
state: Osaka
city: Hidaka
country: Japan
facility: Local Institution - 0303
state: Saitama
city: Ina-machi
country: Japan
facility: Local Institution - 0300
state: Saitama
city: Hamamatsu
country: Japan
facility: Local Institution - 0606
state: Shizuoka
city: Shimotsuga
country: Japan
facility: Local Institution - 0299
state: Tochigi
city: Toyoma
country: Japan
facility: Local Institution - 0343
state: Toyama
city: Iwakuni
country: Japan
facility: Local Institution - 0542
state: Yamaguchi
city: Akashi
country: Japan
facility: Local Institution - 0307
city: Aomori
country: Japan
facility: Local Institution - 0346
city: Fukuoka
country: Japan
facility: Local Institution - 0310
city: Fukushima
country: Japan
facility: Local Institution - 0367
city: Kumamoto
country: Japan
facility: Local Institution - 0308
city: Osaka
country: Japan
facility: Local Institution - 0297
city: Osaka
country: Japan
facility: Local Institution - 0309
city: Cheongju-si
country: Korea, Republic of
facility: Chungbuk National University Hospital
state: Chungcheongbuk-do [Chungbuk]
city: Namdong-gu
country: Korea, Republic of
facility: Gachon University Gil Medical Center
state: Incheon-gwangyeoksi [Incheon]
city: Yangsan
country: Korea, Republic of
facility: Pusan National University Yangsan Hospital
state: Kyǒngsangnam-do
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital
state: Pusan-Kwangyǒkshi
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: The Catholic Univ. of Korea Seoul St. Mary's Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Saltillo
country: Mexico
facility: Local Institution - 0583
state: Coahuila
city: Mexico City
country: Mexico
facility: Local Institution - 0176
state: DIF
city: Pachuca
country: Mexico
facility: Local Institution - 0579
state: Hidalgo
city: Guadalajara
country: Mexico
facility: Local Institution - 0178
state: Jalisco
city: Monterrey
country: Mexico
facility: Local Institution - 0591
state: Nuevo León
city: Chihuahua
country: Mexico
facility: Local Institution - 0175
city: Puebla
country: Mexico
facility: Local Institution - 0181
city: Puebla
country: Mexico
facility: Local Institution - 0638
city: Veracruz
country: Mexico
facility: Local Institution - 0180
city: Maastricht
country: Netherlands
facility: Local Institution - 0615
state: Limburg
city: Amsterdam
country: Netherlands
facility: Local Institution - 0594
state: Noord-Holland
city: Wrocław
country: Poland
facility: Local Institution - 0205
state: Dolnośląskie
city: Lublin
country: Poland
facility: Local Institution - 0080
state: Lubelskie
city: Gorlice
country: Poland
facility: Local Institution - 0206
state: Małopolskie
city: Kraków
country: Poland
facility: Local Institution - 0079
state: Małopolskie
city: Prabuty
country: Poland
facility: Local Institution - 0077
state: Pomorskie
city: Poznan
country: Poland
facility: Local Institution - 0209
state: Wielkopolskie
city: Bydgoszcz
country: Poland
facility: Local Institution - 0076
city: Katowice
country: Poland
facility: Local Institution - 0078
city: Lisbon
country: Portugal
facility: Local Institution - 0509
state: Lisboa
city: Coimbra
country: Portugal
facility: Local Institution - 0510
city: Porto
country: Portugal
facility: Local Institution - 0553
city: Bucharest
country: Romania
facility: Local Institution - 0272
state: București
city: Bucharest
country: Romania
facility: Local Institution - 0261
state: București
city: Cluj-Napoca
country: Romania
facility: Local Institution - 0276
state: Cluj
city: Florești
country: Romania
facility: Local Institution - 0268
state: Cluj
city: Ovidiu
country: Romania
facility: Local Institution - 0275
state: Constanța
city: Craiova
country: Romania
facility: Local Institution - 0271
state: Dolj
city: Ploiești
country: Romania
facility: Local Institution - 0269
state: Prahova
city: Timișoara
country: Romania
facility: Local Institution - 0592
state: Timiș
city: Cluj
country: Romania
facility: Local Institution - 0270
city: Cluj
country: Romania
facility: Local Institution - 0273
city: Constanța
country: Romania
facility: Local Institution - 0590
city: Iași
country: Romania
facility: Local Institution - 0266
city: Iași
country: Romania
facility: Local Institution - 0260
city: Jeddah
country: Saudi Arabia
facility: Local Institution - 0614
state: Makkah Al Mukarramah
city: Riyadh
country: Saudi Arabia
facility: Local Institution - 0602
city: Riyadh
country: Saudi Arabia
facility: Local Institution - 0562
city: A Coruña
country: Spain
facility: Local Institution - 0499
state: A Coruña [La Coruña]
city: Santiago de Compostela
country: Spain
facility: Local Institution - 0506
state: A Coruña [La Coruña]
city: Barcelona
country: Spain
facility: Local Institution - 0501
state: Barcelona [Barcelona]
city: Hospitalet
country: Spain
facility: Local Institution - 0497
state: Barcelona [Barcelona]
city: Barcelona
country: Spain
facility: Local Institution - 0505
state: Catalunya [Cataluña]
city: Palma
country: Spain
facility: Local Institution - 0508
state: Illes Balears [Islas Baleares]
city: Madrid
country: Spain
facility: Local Institution - 0500
state: Madrid, Comunidad De
city: Madrid
country: Spain
facility: Local Institution - 0503
state: Madrid, Comunidad De
city: Madrid
country: Spain
facility: Local Institution - 0496
state: Madrid, Comunidad De
city: Majadahonda
country: Spain
facility: Local Institution - 0498
state: Madrid, Comunidad De
city: Pontevedra
country: Spain
facility: Local Institution - 0669
state: Pontevedra [Pontevedra]
city: Valencia
country: Spain
facility: Local Institution - 0640
state: València
city: Madrid
country: Spain
facility: Local Institution - 0504
city: Málaga
country: Spain
facility: Local Institution - 0502
city: Sevilla
country: Spain
facility: Local Institution - 0507
city: València
country: Spain
facility: Local Institution - 0495
city: Münsterlingen
country: Switzerland
facility: Local Institution - 0536
city: Tainan City
country: Taiwan
facility: Chi Mei Hospital - Liouying Branch
state: Tainan
city: Taipei City
country: Taiwan
facility: Tri-Service General Hospital
state: Taipei
city: New Taipei
country: Taiwan
facility: Taipei Medical University Shuang Ho Hospital
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Muang
country: Thailand
facility: Local Institution - 0565
state: Khon Kaen
city: Bangkok
country: Thailand
facility: Local Institution - 0563
state: Krung Thep Maha Nakhon
city: Hatyai
country: Thailand
facility: Local Institution - 0564
state: Songkhla
city: Stanbul
country: Turkey
facility: Local Institution - 0548
state: İstanbul
city: Izmir, Karsiyaka
country: Turkey
facility: Local Institution - 0199
state: İzmir
city: Adana
country: Turkey
facility: Local Institution - 0197
city: Ankara
country: Turkey
facility: Local Institution - 0201
city: Ankara
country: Turkey
facility: Local Institution - 0198
city: Ankara
country: Turkey
facility: Local Institution - 0194
city: Istanbul
country: Turkey
facility: Local Institution - 0549
city: Izmir
country: Turkey
facility: Local Institution - 0200
city: Malatya
country: Turkey
facility: Local Institution - 0550
city: London
country: United Kingdom
facility: University College London Hospital
state: London, City Of
city: London
country: United Kingdom
facility: Guy's & St Thomas' NHS Foundation Trust
state: London, City Of
city: Birmingham
country: United Kingdom
facility: Local Institution - 0092
city: Guildford
country: United Kingdom
facility: Local Institution - 0090
city: Guildford
country: United Kingdom
facility: Local Institution - 0545
city: Manchester
country: United Kingdom
facility: Local Institution - 0093
Study officials:
References: