Clinical trial NCT06928168: Effect of Sleep Extension in Prevention to Sleep Deprivation
Official title: Effect of Sleep Extension in Prevention to Sleep Deprivation on Running Endurance Performance
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Healthy
Keywords: Sleep deprivation
Sleep extension
Endurance running
Fatigue
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
Collaborators: name: Jean Monnet University
First posted: 2025-04-15
Enrollment: 69
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The approach of a competition can be associated to a decrease in sleep duration and quality which can negatively impact athlete's performance and health (injury risk, fall, accident). Ultra-endurance competitions even involve partial and/or total sleep deprivation over one or several nights. Studied investigating this question suggest that endurance performance under sleep deprivation is altered, mainly because of an effect on the rate of perceived exertion (RPE), which regulates effort intensity. One of the methods used by athletes to limit the impact of sleep deprivation in competition is to implement sleep extension in the days prior to a competition. However, few studies have investigated the impact of sleep deprivation et its reproducibility on performance and fatigue during a prolonged running exercise, as well as the efficiency of prior sleep extension. The importance of such a preventive measure might also depend on individual resistance to sleep deprivation, which is variable between persons and could have genetic determinants. This aspect remains under-studied, particularly regarding the impact of sleep deprivation on physical performance. Therefore, this study aims at investigating the effects of sleep deprivation and prior sleep extension on prolonged duration performance.


Eligibility criteria: Inclusion Criteria:

* Volunteer who signed the written consent form.
* Man or woman.
* Aged 18-50.
* Physically active and running at least one session of more than one hour per week.
* Haven't participated in any competition in the month before the first visit.
* Not participating in any competition during the study.
* Usual sleep time between 6h-8h per night.

Exclusion Criteria:

* - Any chronic pathology.
* Working night shift.
* Having sleep disorders: score \> 5 at Pittsburg Sleep Quality Index.
* Excessive sleepiness: score \>10 at Epworth Sleepiness scale.

Primary outcomes:
measure: Performance over a standardized incremental running test
timeFrame: Day 7
Secondary outcomes:
measure: Reproducibility of sleep deprivation effects.
timeFrame: Day 7
measure: Resistance to sleep deprivation and genetic polymorphism
timeFrame: DAy 1
measure: Fatigue (objective and subjective, )
timeFrame: DAy 7
measure: Fatigue (sleepiness)
timeFrame: DAy 7
measure: Fatigue (perception of effort)
timeFrame: DAy 7
measure: Motor function (running biomechanics )
timeFrame: Day 7
measure: Motor function (energy cost)
timeFrame: Day 7
measure: Cognitive function (vigilance)
timeFrame: Day 7
measure: Cognitive function (attention)
timeFrame: Day 7
measure: Cognitive function (inhibition)
timeFrame: Day 7
Other outcomes:
Locations:
city: Saint-etienne
country: France
facility: FEASSON Léonard
Study officials:
affiliation: CHU SAINT-ETIENNE
name: Frédéric ROCHE, PhD
role: PRINCIPAL_INVESTIGATOR
References: