Clinical trial NCT03613038: A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria
Official title: Understanding Communication and Cognitive Impairments in Neurodegenerative Disorders
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Amyotrophic Lateral Sclerosis
Parkinson Disease
Keywords: Dysarthria
Speech motor performance
Speech motor control
Speech kinematics
Lead sponsor: University of Missouri-Columbia
Sponsor class: OTHER
Collaborators: name: National Institute on Deafness and Other Communication Disorders (NIDCD)
First posted: 2018-08-02
Enrollment: 100
Sex: ALL
Minimum age (years): 19
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Two groups of participants i.e., participants with ALS or PD and healthy controls will be asked to repeat sentences that have target words with varying phonetic complexity.
Primary purpose: BASIC_SCIENCE

Brief summary: The goal is to improve the fundamental knowledge about articulatory motor performance in people with Lou Gehrig's disease (also known as ALS) and Parkinson's disease (PD), in order to develop more sensitive assessments for progressive speech loss, which may lead to the improved timing of speech therapies.

Detailed description: The long-term goal is to optimize dysarthria assessment by improving the early detection and tracking of articulatory performance in progressive dysarthrias. The short-term goal of the proposed cross-sectional study is to focus on ALS and PD and quantify articulatory kinematic performance as a function of phonetic complexity, which is experimentally manipulated based on theoretical principles of speech motor development. The research strategy is to use 3D electromagnetic articulography to examine phonetic complexity effects of single word stimuli at the articulatory kinematic level in 15 talkers each with preclinical, mild, and moderate dysarthria, relative to 45 controls. The central hypothesis is that as dysarthria severity increases the discrepancy in articulatory performance, indexed by movement speed, distance, coordination, and variability, between people with dysarthria and typical controls will significantly increase at a lower phonetic complexity level.

Eligibility criteria: Inclusion Criteria:

1. May or may not have a neurological impairment.
2. Age range of 19-90 years.
3. Male or female.
4. Provide written consent before any study specific procedures are performed.
5. Have ability to comply with basic instructions.
6. Monolingual English speaker.
7. Have ability to partake in a 90 minute data collection.

Exclusion Criteria:

1. Any speech, language, cognition, or hearing impairment prior to diagnosis of a neurodegenerative disease.
2. Anyone not appropriate for study participation, as deemed by the principal investigator.

Primary outcomes:
measure: Peak movement speed
timeFrame: Up to 3 months after enrollment
measure: Range of movement
timeFrame: Up to 3 months after enrollment
measure: Duration
timeFrame: Up to 3 months after enrollment
measure: Spatiotemporal movement variability (STI)
timeFrame: Up to 3 months after enrollment
measure: Inter-articulator coordination
timeFrame: Up to 3 months after enrollment
Secondary outcomes:
Other outcomes:
Locations:
city: Fairway
country: United States
facility: University of Kansas Medical Center
state: Kansas
city: Columbia
country: United States
facility: University of Missouri-Columbia
state: Missouri
Study officials:
affiliation: University of Missouri-Columbia
name: Mili Kuruvilla-Dugdale, PhD
role: PRINCIPAL_INVESTIGATOR
References: