louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06583473: The Effectiveness of Integrated Interactive Digital Health Application and Telemonitoring in Patients with Heart Failure and Reduced Ejection Fraction
Official title: The Effectiveness of Integrated Interactive Digital Health Application and Telemonitoring in Patients with Heart Failure and Reduced Ejection Fraction
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Heart Failure
Health Behavior
Keywords: Heart Failure
Interactive digital health application
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2024-09-04
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Patient Source: Patients discharged from the cardiology ward with heart failure.

Intervention Group: Prior to discharge, patients will be provided with and instructed on how to use the "Intelligent Interactive Personal Management System for Heart Failure" as well as a "Bluetooth-enabled blood pressure monitor and scale for remote data transmission."

Control Group: Patients will receive standard medical care.

Assessment Method: The Health-Related Quality of Life Questionnaire (EQ-5D), Kansas City Cardiomyopathy Questionnaire (KCCQ-12), and Functional Assessment of Chronic Illness Therapy - Spiritual Well-Being; The 12-item Spiritual Well-Being Scale (FACIT-Sp-12) will be completed before discharge, and at 1 month, 6 months, and 12 months post-discharge. The average time to complete the questionnaires is 10-15 minutes. Additionally, cardiovascular events and readmission rates will be tracked and analyzed over a 1-year period.


Eligibility criteria: Inclusion Criteria:

Diagnosed with heart failure

Exclusion Criteria:

Inability to independently stand or get out of bed. Unstable condition

Primary outcomes:
measure: Heart failure re-hospitalization rate
timeFrame: 1 Year
measure: Kansas City Cardiomyopathy Questionnaire
timeFrame: 1 Year
measure: EQ-5D
timeFrame: 1 Year
measure: FACIT-Sp-12
timeFrame: 1 Year
Secondary outcomes:
Other outcomes:
Locations:
facility: Linkou Chang Gung Memorial Hospital
Study officials:
References:
Clinical trial NCT01525173: A Safety and Efficacy Study of ALPHAGAN® P and LUMIGAN® in Subjects Previously Treated With Latanoprost for Glaucoma and Ocular Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Glaucoma
Ocular Hypertension
Lead sponsor: Allergan
Sponsor class: INDUSTRY
First posted: 2012-02-02
Enrollment: 137
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will evaluate the efficacy and safety of either bimatoprost 0.01% ophthalmic solution (Lumigan®) alone or bimatoprost 0.01% ophthalmic solution (Lumigan®) and brimonidine tartrate 0.1% ophthalmic solution (Alphagan® P) in combination in patients previously treated with latanoprost 0.005% ophthalmic solution monotherapy who require additional intraocular pressure (IOP) lowering medication.


Eligibility criteria: Inclusion Criteria:

* Ocular hypertension or glaucoma in at least 1 eye
* Visual acuity of 20/100 or better in both eyes

Exclusion Criteria:

* Corneal refractive laser surgery (LASIK, LASEK, PRK, RK) in the study eye(s)
* Intraocular or glaucoma surgery in the past 3 months

Primary outcomes:
measure: Change From Baseline in Mean Diurnal Intraocular Pressure (IOP)
timeFrame: Baseline, Week 12
Secondary outcomes:
Other outcomes:
Locations:
city: Deerfield Beach
country: United States
state: Florida
Study officials:
affiliation: Allergan
name: Medical Director
role: STUDY_DIRECTOR
References:
Clinical trial NCT04885673: High Flow Nasal Cannula in Comparison to Apneic Oxygenation During Foreign Body Removal by Rigid Bronchoscope
Official title: High Flow Nasal Cannula in Comparison to Apneic Oxygenation During Foreign Body Removal by Rigid Bronchoscope
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Anesthesia
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2021-05-13
Enrollment: 64
Sex: ALL
Minimum age (years): 10
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: To compare the effect of HFNC with standard apneic oxygenation on patient oxygenation and airway protection during foreign body removal by rigid bronchoscope.

Detailed description: This study is a prospective, randomized controlled trial, at Ain Shams University hospitals, Cardiovascular surgery hospital (Thoracic surgery unit), Cairo, Egypt. We will include 64 patients planned for foreign body removal by rigid bronchoscope. All patients will be ASA І with recent FB aspiration in the last 72hrs either by history or documented by radiopaque shadow in chest X ray or CT scan. After achievement of anesthesia and full muscle relaxation ventilation started by open mask technique. Then the patients will be divided into two groups according to the oxygenation technique:

Group (A) (32 patients) HFNC (Vapotherm) will be used during the bronchoscopy time flow rate 50 L/min with 100% humidified oxygen and the temperature adjusted to be 38℃ .

Group (B) (32 patients) (control group) using the standard apneic oxygenation through the side port of rigid bronchoscope during the procedure

Eligibility criteria: Inclusion Criteria:

* We will include 64 patients planned for foreign body removal by rigid bronchoscope.
* All patients will be ASA І
* Recent FB aspiration in the last 72hrs either by history or documented by radiopaque shadow in chest X ray or CT scan.

Exclusion Criteria:

* Patients age not more than 40 years old.
* Body weight less than 40 kg.
* Critically ill patients.
* Intubated patients.
* Inhalation of FB more than 72 hrs.

Primary outcomes:
measure: Maintain high level of oxygen saturation during the procedure
timeFrame: During the procedure time
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Samar Mohammed
Study officials:
References:
Clinical trial NCT00170573: Caelyx Biweekly in Heavily Pretreated Patients With Relapsed Ovarian Cancer
Official title: Comparison of Quality of Life in Patients With Platinum-sensitive Recurrent Ovarian, Fallopian Tube and Peritoneal Cancer When Treated With Treatment With Trabectedin/PLD or Standard Platinum-based Therapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Ovarian Cancer
Keywords: Pegylated liposomal doxorubicin
PPE
Ovarian Cancer
Lead sponsor: North Eastern German Society of Gynaecological Oncology
Sponsor class: OTHER
First posted: 2005-09-15
Enrollment: 77
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Effect of biweekly schedule of PLD on dose-limiting toxicity of PPE and patient's quality of life

Detailed description: Pegylated liposomal doxorubicin (PLD) formulation has been approved for the treatment of recurrent ovarian cancer (ROC). Toxic skin reactions e.g. palmar-plantar erythrodysesthesia (PPE) were reported as being the dose-limiting toxicity and have an impact on patients' quality of life (QoL). The primary aim of this study was to optimise the toxicity profile by choosing a biweekly schedule of PLD Furthermore, QoL was investigated. Secondary objective of this study was to evaluate the response rates of this new regimen.

Eligibility criteria: Inclusion Criteria:

* Patients ≥ 18 years of age
* recurrent ovarian, peritoneal, or tubal cancer and prior treatment with platinum- and paclitaxel were eligible to this trial.
* Eastern Cooperative Oncology Group (ECOG) performance status less than 3.
* renal function (serum creatinine 1.25 times the upper limit of normal, glomerular filtration rate greater than 60 ml/min)
* liver function (AST/ ALT three times the upper limit of normal, bilirubin concentrations 1.25 the upper limit of normal)
* bone marrow function (neutrophil count greater than 1.5 x 109/l, and a platelet count greater than 100 x 109/l).

Exclusion Criteria:

* patients with more than 4 chemotherapies in medical history
* severe cardiac disease

Primary outcomes:
measure: Occurrence of Palmar-plantar Erythrodysesthesia (PPE)
timeFrame: through study completion, an average of 18 months
Secondary outcomes:
measure: Overall Survival
timeFrame: for up to 3 years
Other outcomes:
Locations:
Study officials:
affiliation: Charite University, Berlin, Germany
name: Jalid Sehouli
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04143373: Effect of Warm Saline Irrigation on Bleeding in Mandibular Third Molar Surgery
Official title: The Effect of Warm Saline Irrigation on the Amount of Bleeding in Impacted Mandibular Third Molar Surgery: a Split-mouth Single-blinded Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Surgical Blood Loss
Third Molar
Keywords: Warm Saline
Lead sponsor: Tehran University of Medical Sciences
Sponsor class: OTHER
First posted: 2019-10-29
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The objective of this research is to compare the effect of irrigation during impacted mandibular third molar surgery, with normal saline of 25 ± 2 ° C and 37 ± 1 ° C for control and experimental sides, respectively.

Detailed description: The objective of this research is to compare the effect of irrigation during impacted mandibular third molar surgery, with normal saline of 25 ± 2 ° C and 37 ± 1 ° C for control and experimental sides, respectively. For this purpose, 40 mandibular impacted third molars will be randomly allocated to two groups and surgically removed with the abovementioned saline temperatures. Finally, the suctioned liquids and duration of the surgeries will be carefully measured and compared between both sides.

Eligibility criteria: Inclusion criteria

* Being a candidate for bilateral mandibular third molar surgery
* Both mandibular third molars must have a similar inclination to the second molar
* Both mandibular third molars must have same Pell \& Gregory's classification

Exclusion criteria

* Presence of any systemic condition or using any type of medication
* History of allergy to local anesthetic (LA) solutions
* Patients with an active gag reflex
* Pregnant and post-menopause women
* Patients with pericoronitis or any local inflammation

Primary outcomes:
measure: Amount of Bleeding in Cubic Centimetre
timeFrame: Intraoperatively, up to 30 minutes
Secondary outcomes:
measure: Duration of the Surgery in Minutes
timeFrame: Intraoperatively, up to 30 minutes
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: department of oral and maxillofacial surgery, school of dentistry, Tehran university of medical sciences,
Study officials:
affiliation: School of dentistry, Tehran University of Medical Sciences
name: Mahboobe Hasheminasab, DMD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01584973: Changes in Inter-joint Coordination and Muscle Activation After Cruciate Ligament Injury of the Knee Joint
Official title: Changes in Inter-joint Coordination and Muscle Activation After Cruciate Ligament Injury of the Knee Joint
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: To Investigate the Change of Inter-joint Coordination and Muscle Activation in Patients With Cruciate Ligament Injury During Stair Negotiation.
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2012-04-25
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: unilateral cruciate ligament injury or unilateral cruciate ligament reconstructed after 3 month

Brief summary: Stair negotiation is an important activity of daily living. Patients with cruciate ligament injury may have difficulty in stair negotiation because of the proprioception deficit and neuromuscular deficit caused by ligament injury. However, the influence of knee cruciate ligament injury on the control of movement is still unclear. Since inter-joint coordination can provide the information of relationship between angle position and angle velocity, it may be useful to analysis the change of movement pattern.This current study aimed to investigate the change of inter-joint coordination and muscle activation in patients with cruciate ligament injury during stair negotiation.


Eligibility criteria: Inclusion Criteria:

* unilateral cruciate ligament injury or unilateral cruciate ligament reconstructed after 3 month
* able to climb up and down with step-over-step pattern
* BMI within 18 to 30

Exclusion Criteria:

* complex ligament injury
* lower limb fracture in recent years
* meniscus injury
* systematic disorder which would affect the balance and ambulation

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: School & Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University
Study officials:
affiliation: School of physical therapy, National Taiwan University
name: Wei-Li Hsu, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00154973: Expression of Hypoxia-Inducible Factor-α in Oral Precancers and Cancers
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Oral Cancer
Keywords: oral precancers
oral cancer
hypoxia-inducible factor
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2005-09-12
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: RETROSPECTIVE

Brief summary: Expression of hypoxia-inducible factor-α in oral precancers and cancers

Detailed description: Expression of hypoxia-inducible factor-α in oral precancers and cancers

Eligibility criteria: Inclusion Criteria:

* oral cancer specimens

Exclusion Criteria:

* not oral cancer specimens

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: Chun-Pin Chiang, DMSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06901973: Distal Radius Fractures in Adults: A Multi-Center Study in South Kivu
Official title: Epidemiological, Radiological, Therapeutic and Evolutionary Aspects of Distal Radius Fractures in Adults in South Kivu: a Multi-center Cross-sectional Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Distal Radius Fracture
Keywords: DISTAL RADIUS FRACTURES
Lead sponsor: Official University of Bukavu
Sponsor class: OTHER
First posted: 2025-03-30
Enrollment: 192
Sex: ALL
Minimum age (years): 17
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population consists of adults diagnosed with distal radius fractures (DRFs) who were admitted, treated, and followed up across 16 hospitals and university medical centers in the Bukavu Health District, South Kivu, Eastern Democratic Republic of Congo (DRC), between January 1, 2018, and December 31, 2023.

Brief summary: The goal of this observational study is to describe the epidemiological, radiological, therapeutic, and evolutionary characteristics of distal radius fractures in adults in the Bukavu Health District, South Kivu, DRC.

. The main question it aims to answer is:

• What are the epidemiological, radiological, therapeutic, and evolutionary characteristics of distal radius fractures in adults in South Kivu, and how does intrafocal nailing influence outcomes such as consolidation time and complication rates in this population?

Participants who have already operated for distal radius fracture will be enrolled in this study.


Eligibility criteria: Inclusion Criteria:

* Patients aged 17 years or older at the time of injury.
* Diagnosed with a distal radius fracture via clinical and radiological assessment.
* Admitted, treated, and followed up at one of the 16 participating institutions.
* Complete medical records available, including epidemiological, clinical, radiological, therapeutic, and outcome data.

Exclusion Criteria:

* Patients under 17 years of age.

  * Incomplete or missing medical records.
  * Fractures not involving the distal radius.
  * Patients transferred to non-participating facilities without follow-up data.

Primary outcomes:
measure: Time to consolidation
timeFrame: 45 days
Secondary outcomes:
Other outcomes:
Locations:
city: Bukavu
country: Congo, The Democratic Republic of the
facility: University Clinics of Bukavu
state: South Kivu
Study officials:
References:
citation: 1. Rundgren J, et al. BMC Musculoskelet Disord. 2020;21(1):88. 2. Chinta SR, et al. J Hand Surg Am. 2024;49(2):123-30. 3. Dworkin M, et al. J Am Acad Orthop Surg Glob Res Rev. 2024;8(4):e23.00282.
Clinical trial NCT05414773: Zeiss® IOLMaster 700 Corneal Topography Module Comparison With Schwind's Sirius Corneal Topography®
Official title: Zeiss® IOLMaster 700 Corneal Topography Module Comparison With Schwind's Sirius Corneal Topography®
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cataract
Lead sponsor: Versailles Hospital
Sponsor class: OTHER
First posted: 2022-06-10
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: In order to determine the intraocular lens to be implanted during cataract surgery, keratometry and axial length must be measured in preoperative. The axial length is obtained by ocular ultrasound mode B. Keratometry is obtained by means of an automatic refractometer or corneal topography. Currently, ultrasound scanners are being developed with a topography module to combine axial length and keratometry measurement. The investigators want to evaluate the corneal topography module of the Zeiss® IOL Master 700 biometer.


Eligibility criteria: Inclusion Criteria:

* Men and Women Requiring CHV Cataract Surgery
* Aged 18 or over
* Insured under a social security scheme
* Having been informed of the clinical study and having given oral express consent

Exclusion Criteria:

* Person unable to express consent
* Patient with a history of corneal dystrophy, corneal refractive surgery or keratoconus.
* History of chronic corneal disease

Primary outcomes:
measure: keratometry measurements
timeFrame: day 1
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05114473: Efficacy of Pain Neuroscience Education in Genito-Pelvic Pain/Penetration Disorder. A Randomized Controlled Trial.
Official title: Educational Program Interventions for Patients Suffering From Persistent Pelvic Pain and Their Effects Over Pain and Functionality. A Multi-centered Randomized Clinical Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain
Dysfunction Sexual
Lead sponsor: University of Valencia
Sponsor class: OTHER
First posted: 2021-11-10
Enrollment: 69
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two groups receiving intervention and one serving as control
Primary purpose: TREATMENT

Brief summary: Patients suffering pelvic persistent pain deal with significant pain that affects their quality of life. Often, conservative treatment interventions are scarce for these patients and are therefore not considered. Education has been developed as a relevant tool in the treatment of patients who suffer from chronic pain or any other pain processing alterations, and has the potential to become a powerfull treatment alternative.

Detailed description: In this intervention, the effects of implementing educational programs in patients suffering from pelvic persistent pain will be assessed.

Patients with pelvic persistent pain have both problems directly related with their pain and other issues that appear derived from suffering pain over a determined period, such as alterations in the sexuality or overall quality of life. Facing these patients is a challenge for professionals, and many can't find the treatment that properly fits the patient's clinical presentation.

Education, and educating patients on their problem, is an exponentially growing alternative used in Physical Therapy involving patients who suffer from a dysfunctional pain, chronic pain, or any kind of pain presentation that affects the patient's well-being.

This study will assess firstly if the implementation of a pain-related education program is relevant in the treatment of pelvic persistent pain, and will further observe which modality (presential workshops or online-accessed material) is the most effective involving adherence and improvement.

Eligibility criteria: Inclusion Criteria:

* Patients over 18 years-old suffering from dyspareunia for more than 3 months

Exclusion Criteria:

* Patients suffering from a previous medical condition that explains logically the presence of pain

Primary outcomes:
measure: Visual Analogue Scale
timeFrame: Baseline to week 4
Secondary outcomes:
measure: Pain Catastrophizing Scale
timeFrame: Baseline to week 4
measure: Survey of Pain Attitudes
timeFrame: Baseline to week 4
measure: Female Sexual Function Index
timeFrame: Baseline to week 4
Other outcomes:
Locations:
city: Valencia
country: Spain
facility: Faculty of Physical Therapy
Study officials:
References: