Clinical trial NCT06117462: Frailty in Critical Care Unit's Patients
Official title: Frailty in Critical Care Unit's Patients
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: CFS
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-11-07
Enrollment: 116
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The initial clinical data will include socio-demographic data, comorbidities (diabetes mellitus (DM), hypertension (HTN), ischemic heart disease (IHD), chronic kidney disease (CKD), chronic liver disease, chronic pulmonary disease, or malignancy), in addition to the acute insult causing the admission.

Candidates will be divided into two groups, group (A): \>60 years, and group (B) aged between 18-60 years, both groups will be assessed using the Clinical Frailty Scale (CFS) giving patients who are very fit score one and those who are terminally ill score nine.

Brief summary: In the study ,investigator aim to evaluate the frailty syndrome in critically ill patients, in both young and old populations,to determine its imapct on outcome, and impact of ICU in fraility


Eligibility criteria: Inclusion Criteria:

* All ICU patients \>18 years

Exclusion Criteria:

* Age \<18 years

Primary outcomes:
measure: detect the impact of frailty on outcome(hospital stay and mortality).In Critical care units patients.
timeFrame: the CFS before hospital admission and at day up to 1 week of discharge from CCU, CFS mininum 1 ,maximum 9 patient's basal score[ pre intervention] on day of admission and the outcome score at day of discharge [5day],score 1better than higher
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
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citation: de Rooij SE, Govers A, Korevaar JC, Abu-Hanna A, Levi M, de Jonge E. Short-term and long-term mortality in very elderly patients admitted to an intensive care unit. Intensive Care Med. 2006 Jul;32(7):1039-44. doi: 10.1007/s00134-006-0171-0. Epub 2006 May 9.
citation: Guidet B, de Lange DW, Boumendil A, Leaver S, Watson X, Boulanger C, Szczeklik W, Artigas A, Morandi A, Andersen F, Zafeiridis T, Jung C, Moreno R, Walther S, Oeyen S, Schefold JC, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjolner J, Flaatten H; VIP2 study group. The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Intensive Care Med. 2020 Jan;46(1):57-69. doi: 10.1007/s00134-019-05853-1. Epub 2019 Nov 29.
citation: Darvall JN, Bellomo R, Bailey M, Young PJ, Rockwood K, Pilcher D. Impact of frailty on persistent critical illness: a population-based cohort study. Intensive Care Med. 2022 Mar;48(3):343-351. doi: 10.1007/s00134-022-06617-0. Epub 2022 Feb 4.
citation: Muscedere J, Waters B, Varambally A, Bagshaw SM, Boyd JG, Maslove D, Sibley S, Rockwood K. The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis. Intensive Care Med. 2017 Aug;43(8):1105-1122. doi: 10.1007/s00134-017-4867-0. Epub 2017 Jul 4.