louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01363973: Effect of Transcutaneous Electrical Stimulation on Post-stroke Dysphagic Patients
Official title: Pilot Study to Evaluate the Efficacy and Safety of Transcutaneous Electrical Stimulation on Swallowing in Patients With Oropharyngeal Dysphagia After Stroke
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dysphagia
Keywords: oropharyngeal dysphagia
post-stroke
Lead sponsor: Hospital de Mataró
Sponsor class: OTHER
Collaborators: name: Consorcio Centro de Investigación Biomédica en Red (CIBER)
First posted: 2011-06-02
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Oropharyngeal dysphagia (OD, swallowing dysfunction) is a major complaint following stroke. Despite its enormous impact on functional capacity, quality of life, and survival, OD is both underestimated and underdiagnosed as a cause of major nutritional and respiratory complications in stroke patients. A recent systematic review on the effects of rehabilitation therapy on OD concluded that although some positive effects were found, the number of studies was small, many of them had methodological problems and there was a need for further research using randomized controlled trials. Transcutaneous electrical stimulation was approved by the FDA as a treatment of dysphagia in June 2001 and is traditionally used to activate pharyngeal muscles through stimulation of peripheral motor nerves (neuromuscular electrical estimulation, NMES). However, their real effectiveness and safety in the treatment of dysphagia is still matter of discussion (Logemann Dysphagia 2007, Ludlow dysphagia 2007) and studies evaluating NMES therapy, present discordant results. On the other hand, in recent years, transcutaneous electrical stimulation is beginning to use as a sensory strategy (Gallas 2010), avoiding muscle contraction during the treatment.Our research strategy includes the assessment of the therapeutic effect of these two main strategies using transcutaneous electrical stimulation on swallow physiology and clinical outcomes of post-stroke dysphagic patients.


Eligibility criteria: Inclusion Criteria:

* Age \> 18
* Background of swallowing difficulties associated with stroke, more than 3 months of evolution
* Study explained and signed informed consent

Exclusion Criteria:

* Patients who are suspected or can not meet the protocol. patients who are participating or have participated in a trial last 4 weeks. Patients with active cancer Patients with active infectious process. patients with severe dementia or inability to communicate. patients with neurodegenerative diseases. patients with pacemakers. patients with implanted electrodes. patients with epilepsy or seizure disorders. patients with gastroesophageal reflux.

Primary outcomes:
measure: Safety of swallow
timeFrame: 5 days
Secondary outcomes:
measure: Efficacy of swallow
timeFrame: 5 days
Other outcomes:
Locations:
city: Mataró
country: Spain
facility: Hospital de Mataró
state: Barcelona
Study officials:
References:
Clinical trial NCT06424873: Dynamic Whole-body PET/CT Imaging in Clinical Oncology
Official title: Dynamic Whole-body PET/CT Imaging in Clinical Oncology
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cancer
Lead sponsor: University Hospital, Geneva
Sponsor class: OTHER
First posted: 2024-05-22
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: PET/CT
Primary purpose: DIAGNOSTIC

Brief summary: The goal of this clinical trial is to to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times in patient with oncologic pathology .

The main question\[s\] it aims to answer are:

* \[question 1\]
* \[question 2\] Participants will \[describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items\].

Detailed description: Whole body hybrid PET/CT imaging, making use of the standardized uptake value (SUV), is well established in clinical setting for diagnosis and staging, treatment response monitoring and radiation therapy treatment planning of a wide range of oncologic malignancies. However, the SUV metric derived from static PET data does not capture the dynamics of the PET probe biodistribution in the body.

The present work proposes to fill in this notable gap: namely to merge whole-body and dynamic PET/CT imaging, to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times. Our proposed approach has the potential to significantly enhance diagnostic, prognostic and treatment response monitoring capabilities of PET/CT and to fundamentally alter routine clinical practice.

Eligibility criteria: Inclusion Criteria:

1. Patients clinically indicated for whole-body PET evaluation.
2. Patient must agree to lie still in the camera.
3. Patient must be able to comply with study procedures.
4. Patient must be able to provide informed consent.

Exclusion Criteria:

1. Patients \< 18 years of age.
2. Pregnant women are excluded.

Primary outcomes:
measure: Standard SUV measurement metric
timeFrame: through study completion , an average of 2 years
Secondary outcomes:
measure: Image quality
timeFrame: through study completion , an average of 2 years
measure: Certainty in diagnosis of FDG-avid processes
timeFrame: through study completion , an average of 2 years
Other outcomes:
Locations:
city: Geneva
country: Switzerland
facility: Geneva University Hospitals
Study officials:
References:
Clinical trial NCT06197373: Laparoscopic Cholecystectomy After ERCP
Official title: Outcomes of Early and Late Laparoscopic Cholecystectomy (LC) After Endoscopic Retrograde CholangioPancreatography (ERCP), Prospective Study .
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Laparoscopic Cholecystectomy
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-01-09
Enrollment: 60
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Female patient present with CBD obstruction and GB stones So Undergoing ERCP then Laparoscopic cholecystectomy

Brief summary: Evaluation of outcomes of early and late laparoscopic cholecystectomy after ERCP

Detailed description: Evaluation of both benefits and harms of doing laparoscopic cholecystectomy early within first 72 hours and late from the third day up to 2 months after ERCP

Eligibility criteria: Inclusion Criteria:

* female patient
* 18-60 years old

Exclusion Criteria:

* male patient
* extremes of age less than 18 and more than 60

Primary outcomes:
measure: Duration of the operation
timeFrame: 5 hours
measure: Bleeding during operation
timeFrame: 5 hours
measure: Hospital stay duration
timeFrame: 7 days
measure: Rate of Conversion to open cholecystectomy
timeFrame: 5 hours
Secondary outcomes:
measure: Total cost of the medical service in both categories
timeFrame: 2 months
Other outcomes:
Locations:
Study officials:
affiliation: Assiut University
name: Thabet
role: STUDY_DIRECTOR
References:
Clinical trial NCT02726373: Comparison of Intermittent vs. Continuous Walking in MS
Official title: The Effect of Intermittent vs. Continuous Walking Training on Walking Endurance and Fatigue in People With Multiple Sclerosis: a Randomized, Crossover Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Multiple Sclerosis, Endurance
Lead sponsor: Hunter College of City University of New York
Sponsor class: OTHER
First posted: 2016-04-01
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Objective: To compare effects of an intermittent and continuous walking program on walking endurance and fatigue in people with multiple sclerosis (MS).A randomized crossover prospective method was used.The intervention consisted of eight 6-minute-long walks (2x/week for 4 weeks). The continuous condition consisted of 6 continuous minutes of walking. The intermittent condition consisted of three 2-minute bouts with 2-minute rests. After a 4-week detraining period, participants performed the second training condition.


Eligibility criteria: Inclusion Criteria:

* Positive diagnosis of MS
* Ambulatory for at least 6 minutes with or without an assistive device (e.g. cane, crutches or orthotics)
* Ability to read, understand, and sign an informed consent form

Exclusion Criteria:

* Evidence of exacerbation in the prior three months as defined by a treating physician
* Orthopedic or cardiovascular condition that would interfere with ability to walk for 6 continuous minutes,
* Currently being on an active physical rehabilitation program

Primary outcomes:
measure: Pre to post change in 6 Minute walk test distance
timeFrame: 4 weeks
Secondary outcomes:
measure: Visual Analog Scale of fatigue
timeFrame: 4 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT07020273: CONNECT Cancer Survivors With Tobacco Treatment
Official title: Cancer Prevention by Reducing Tobacco With Informatics and Chronic Care Approaches Trial (CONNECT)
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Tobacco Use
Tobacco Use Cessation
Smoking Cessation
Nicotine Addiction
Tobacco Smoking
Keywords: Patient Reported Outcomes
Tobacco Treatment
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2025-06-13
Enrollment: 2400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomization occurs at the clinic level. For pragmatic concerns, the investigators expect to recruit from multiple clinics and randomization will be stratified by department to minimize the clinic effect. Clinics will be randomized on a 1:1 basis to ELEVATE-S or ELEVATE. Patients within a clinic will be assigned to the same arm.
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the comparative effectiveness of two different informatics-enabled implementation strategies on increasing tobacco treatment and improving smoking cessation rates for cancer control and prevention. This will be done via a two-arm pragmatic cluster randomized trial (CRT) to test the effectiveness of nudges to change (ELEVATE-S) vs. quit-focused usual care (ELEVATE) in increasing tobacco treatment (use of medication, brief advice, or referral to external counseling) and smoking cessation.


Eligibility criteria: Eligibility Criteria:

* Be receiving care at a participating clinic
* Report current tobacco use (assessed by the rooming staff during the index visit)
* Have a completed appointment with a participating clinic
* Be an adult (at least 18 years old).

Primary outcomes:
measure: Patient receipt of tobacco use treatment, i.e. Tobacco use treatment (TUT) Reach
timeFrame: Up to 6 months post-enrollment
Secondary outcomes:
measure: Patient receipt of tobacco use treatment - behavioral intervention.
timeFrame: Up to 6 months post-enrollment
measure: Patient receipt of tobacco use treatment - medication.
timeFrame: Up to 6 months post-enrollment
measure: Patient smoking abstinence
timeFrame: Up to 6 months post-enrollment
Other outcomes:
measure: Patient receipt of tobacco use treatment, i.e. Tobacco use treatment (TUT) Reach
timeFrame: Up to 12 months post-enrollment
measure: Patient receipt of tobacco use treatment - behavioral intervention.
timeFrame: Up to 12 months post-enrollment
measure: Patient receipt of tobacco use treatment - medication.
timeFrame: Up to 12 months post-enrollment
measure: Patient smoking abstinence
timeFrame: Up to 12 months post-enrollment
measure: Patient bioverified smoking
timeFrame: Up to 12 months post-enrollment
Locations:
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
Study officials:
affiliation: Washington University School of Medicine
name: Li-Shiun Chen, M.D., MPH, ScD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06051773: Evaluation of Muscle Involvement in Systemic Sclerosis
Official title: Evaluation of Muscle Involvement in Systemic Sclerosis
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Systemic Sclerosis
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2023-09-25
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with systemic sclerosis

Brief summary: Muscle involvement is poorly described in patients with systemic sclerosis (SSc) .

The prevalence of muscle damage is evaluated at 5-95 % of SSc patients, particularly due to variable definitions depending on the series in the scientific litterature. Muscle clinicobiological and histological presentation an response to immunosuppressive treatments are highly variable. Muscle involvement defined by creatinine kinase (CK) elevation, the presence of electromyography (EMG) abnormalities and/or muscle magnetic resonance imaging (MRI) hyperintensities and/or muscle biopsy inflammation appears to be associated with diffuse SSc, the presence of cardiac damage, and anti-PM-Scl antibodies.

The main objective is to describe muscular manifestations associated with SSc.

Secondary objectives are:

* to compare characteristics between SSc patients with and without muscle involvement
* to determine homogeneous groups of SSc patients with muscle involvement


Eligibility criteria: Inclusion Criteria:

* Patients with systemic sclerosis according to 2013 ACR/EULAR classification criteria

Primary outcomes:
measure: Number of patients with muscle involvement
timeFrame: baseline (J0)
Secondary outcomes:
Other outcomes:
Locations:
city: Nancy
country: France
facility: Paul Decker
Study officials:
References:
Clinical trial NCT01136473: Mechanism of Aphakic and Pseudophakic Glaucoma in Pediatric Patients
Official title: Mechanism of Aphakic and Pseudophakic Glaucoma in Pediatric Patients: Exploring the Pathophysiology Through Lens Epithelial Cell Culture and Isolation of Candidate Factors From Aqueous Humor
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Congenital Cataract
Aphakic or Pseudophakic Glaucoma
Keywords: congenital cataract
aphakic
pseudophakic glaucoma
pediatric patients
Lead sponsor: Carmel Medical Center
Sponsor class: OTHER
First posted: 2010-06-03
Enrollment: 40
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: children 0-18

Brief summary: In cell cultures, lens epithelial cells and trabecular meshwork cells will be exposed to aqueous humor from pediatric eyes undergoing cataract removal surgery. Cytokine analysis of candidate factors will be performed before and after exposure to lens epithelial.

Detailed description: Aqueous from the anterior chamber will be withdrawn before surgery. Then the lens capsule will be opened (capsulorhexis) and removed. The lens material will be removed. All 3 components will be sent to the lab.

Lens epithelial cells will be isolated and will be used in a co-culture setup with trabecular cells to investigate the interactions between lens cells and trabecular cells. Understanding the interaction between young and adult lens cells on trabecular cell will shed light on mechanism of infantile aphakic glaucoma.

Aqueous humor taken out before cataract surgery and before glaucoma operation of aphakic eyes will be used for analysis of growth factor and cytokines in the Aphakic eye using proteins membrane arrays. Eyes before cataract surgery will be used as controls. Such analysis will shed light on the possible factors affecting trabecular cells in aphakic eye.

Eligibility criteria: Inclusion Criteria:

* children with congenital cataract and are going to do removal surgery
* children with aphakic or pseudophakic glaucoma and are going to do glaucoma surgery
* both of parents are able to sign the INFORMED CONSENT FORM

Exclusion Criteria:

* patients with other eye diseases apart from congenital cataract(in children with congenital cataract) and aphakic or pseudophakic glaucoma (in children with aphakic or pseudophakic glaucoma)

Primary outcomes:
measure: cell culture
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Carmel Medical Center
Study officials:
affiliation: Carmel Medical Center
name: Orna Geyer, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06188273: Impact of Skeletal Muscle Quality and Loss on the Outcome of Liver Transplantation
Official title: Impact of Skeletal Muscle Quality and Loss on the Outcome of Liver Transplantation
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Liver Transplantation
Muscle Loss
Muscle Quality
Lead sponsor: Zhejiang University
Sponsor class: OTHER
Collaborators: name: First Affiliated Hospital of Zhejiang University
name: Shulan (Hangzhou) Hospital
name: The Affiliated Hospital of Qingdao University
name: West China Hospital
name: Huashan Hospital
First posted: 2024-01-03
Enrollment: 800
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Liver transplant patients from multiple transplant centers in China

Brief summary: CT imaging-based skeletal muscle assessment has been found to predict the outcomes of many diseases. Previous evidence revealed that pre-transplant muscle quality and post-transplant muscle loss were associated with transplant outcomes. However, there is no prospective study supporting the aforementioned conclusions. This study aims to prospectively include liver transplant patients from multiple transplant centers, collecting their pre-transplant CT images as well as post-transplant CT images at specific time points. The objective is to further explore and clarify the correlation between skeletal muscle assessment and the prognosis of liver transplant patients. The goal is to provide guidance for peri-transplant health monitoring and disease intervention for liver transplant patients.


Eligibility criteria: Inclusion Criteria:

* Adult patients undergoing deceased donor liver transplantation (DDLT) for the first time

Exclusion Criteria:

* Pediatric transplants
* Presence of portal vein tumor thrombus according to imageing before transplantation
* Presence of macrovascular invasion according to imageing before transplantation
* Re-transplants
* Multi-organ transplants
* Patients who died within 30 days after transplantation
* Patients diagnosed with skeletal muscle diseases (e.g. muscle atrophy)
* Patients with serious medical conditions such as heart failure, persistent infection, and renal insufficiency.

Primary outcomes:
measure: Postoperative mortality
timeFrame: 2024.1.1-2027.1.1
measure: Postoperative recurrence of liver cancer
timeFrame: 2024.1.1-2027.1.1
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04897373: Active Older Adult Program on Health and Well-being
Official title: The Effects of an Active Older Adult Program at the Dan Abraham Healthy Living Center on Health and Well-being
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Older Adult
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2021-05-21
Enrollment: 33
Sex: ALL
Minimum age (years): 55
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The target population consists of The Dan Abraham Healthy Living Center (DAHLC) members 60 years of age and older who plan to participate in the Active Older Adult Program.

Brief summary: The purpose of this study is to determine whether a structured 12-week program designed for older adults will improve physical function and, in parallel, circulating biomarkers of aging


Eligibility criteria: Inclusion Criteria:

* Men and women age 55 years or older.
* Membership at the DAHLC.
* New to AOA (Active Older Adult) Program and commitment to full participation in the twelve-week program.
* Must be able to get down and off the floor with little assistance.

Exclusion Criteria:

* Inability to provide informed consent.
* Previous participation in the AOA Program at the DAHLC.

Primary outcomes:
measure: Change in repeated chair rise time
timeFrame: Baseline to end of study, approximately 14 weeks
measure: Change in plasma protein levels reflective of biological age
timeFrame: Baseline, week 12
measure: Change in expression of senescence-related genes in blood cells
timeFrame: Baseline, week 12
Secondary outcomes:
measure: Change in Self-reported Physical Function
timeFrame: Baseline, week 12
measure: Change in Performance-based Physical Function
timeFrame: Baseline, week 12
measure: Change in Mental Function
timeFrame: Baseline, week 12
measure: Change in self-assessment of well-being
timeFrame: Baseline, week 12
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Nathan LeBrasseur, PhD, MS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04927273: Availability of Spine Neuronavigation in Africa
Official title: Prevalence of Spine Surgery Navigation Techniques and Availability in Africa: A Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spine Disease
Keywords: Access
Africa
computer-assisted surgery
neuronavigation
spine surgery
Lead sponsor: Association of Future African Neurosurgeons, Yaounde, Cameroon
Sponsor class: OTHER
Collaborators: name: Washington University School of Medicine
First posted: 2021-06-15
Enrollment: 113
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Neurological and orthopedic surgery residents, fellows and consultants working in Africa.

Brief summary: In this study, the availability of spine neuronavigation in Africa was evaluated. Access to surgical equipment is an important goal of global surgery and global neurosurgery. The study findings show that there are regional differences in access to spine neuronavigation techniques and highlight that the major barriers to increased prevalence are cost and lack of trained personnel.


Eligibility criteria: Inclusion Criteria:

* Neurological and orthopedic surgery residents, fellows and consultants working in Africa.

Exclusion Criteria:

-

Primary outcomes:
measure: Availability of neuronavigation
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Yaounde
country: Cameroon
facility: Association of Future African Neurosurgeons
state: Centre
Study officials:
References: