Clinical trial NCT03942276: Effects of Different Exercises Interventions in Post-menopausal Women
Official title: Acute and Chronic Health Effects of Different Exercises Interventions in Post-menopausal Women: a Clinical, Controlled and Randomized Study
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Hypertension
Menopause
Keywords: Blood pressure
Menopause
Hypertension
Exercise
Alternative training
Lead sponsor: Federal University of Uberlandia
Sponsor class: OTHER
First posted: 2019-05-08
Enrollment: 60
Sex: FEMALE
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will compare different exercise training protocols on health parameters of postmenopausal women. The hypothesis is that short duration high intensity interval training will promote different effects of long duration moderate intensity training.

Detailed description: Exercise load control still not a consensus as to the most effective strategy for improving health parameters in postmenopausal women. In this way, the volunteers will perform anthropometric and body composition assessments, climacteric symptoms and sleep quality evaluations, blood pressure reactivity, resting blood pressure and heart rate and ambulatorial blood pressure monitoring, before and after 12 weeks of training.

Eligibility criteria: Inclusion Criteria:

* being postmenopausal (amenorrhea of at least 12 months and \[FSH\]\> 40 mlU/ml); be controlled hypertension; not to undergo drug treatment with β-blockers; not make use of sex hormone therapies; do not present physical problems or cardiovascular complications that prevent the performance of physical exercises; present attestation of a cardiologist proving that they are able to perform physical exercises.

Exclusion Criteria:

* Do not attend the collection site on the day and time programmed more than once in the acute phase of the study; missing more than 2 consecutive sessions or 6 alternates in the chronic phase of the study; unable to perform the proposed training protocols; change in drug therapy during the intervention.

Primary outcomes:
measure: Changes in Ambulatorial Blood Pressure
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in Resting Blood Pressure
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
Secondary outcomes:
measure: Changes in Heart Rate Variability
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in Ambulatorial Blood Pressure Variability
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in Blood pressure reactivity
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in salivary oxidative stress (umol/L)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in salivary oxidative stress (units/mg prot)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in salivary oxidative stress (μmol H2O2/min/g prot)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in salivary oxidative stress (nM)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in blood biomarkers (mg/dL)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in blood biomarkers (nM)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in blood biomarkers (pg/mL)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in blood biomarkers (mg/L)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in blood biomarkers (Units/mg de prot)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
measure: Changes in blood biomarkers (umol/L)
timeFrame: Before and within 72 hours after 12 weeks of exercise training/control
Other outcomes:
Locations:
city: Uberlandia
country: Brazil
facility: Guilherme Morais Puga
state: Minas Gerais
Study officials:
References: