Clinical trial NCT03673644: Impact of Glaucoma and Visual Field Loss on Life Space
Official title: Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Primary Open-angle Glaucoma
Lead sponsor: University of Alabama at Birmingham
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2018-09-17
Enrollment: 88
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants that are enrolled in the Early Detection of Glaucoma Progression using a Novel Individualized Approach (IRB-300000301) or in the African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the Lamina Cribrosa in Progression (IRB-161115004).

Brief summary: Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on the other extreme. Primary open-angle glaucoma (POAG) is a chronic, progressive optic neuropathy that can lead to gradual loss of vision in the peripheral field and central vision. Older adults with POAG have an increased risk for motor vehicle collisions and falls. Moreover, existing studies suggest that patients with POAG exhibit more postural sway while standing as measured by a balance platform and also tend to walk more slowly than those who are normally sighted and free of ocular disease. While these disturbances likely influence mobility, there has been little research directly assessing the impact of POAG on mobility. This study will assess the impact of POAG on life space (one aspect of mobility) and will determine whether difficulties with life space are associated with difficulties experienced under conditions of dim lighting.

Detailed description: Aim 1: To examine the extent of life space in older adults with POAG using the Life Space Questionnaire and to examine whether life space in persons with POAG is associated with the magnitude of visual field impairment.

Aim 2: To examine difficulties seeing under dim illumination and at night in older adults with POAG using the Low Luminance Questionnaire and to examine whether greater difficulty in seeing under dim illumination and at night is related to the magnitude of visual field loss.

Aim 3: To examine the relationship in older adults with POAG between visual problems seeing under dim illumination and at night (Low Luminance Questionnaire) and their life space (Life Space Questionnaire).

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of primary open-angle glaucoma
* Best-corrected visual acuity of 20/40 or better
* Spherical refraction within ± 5 Diopters
* Cylinder refraction within ± 3 Diopters

Exclusion Criteria:

* History of intra-ocular surgery other than uncomplicated cataract or glaucoma surgery
* Significant cognitive impairment

Primary outcomes:
measure: Assessment of life space measured with the Life Space Questionnaire
timeFrame: Day one
Secondary outcomes:
measure: Relationship between the Life Space Questionnaire and vision loss
timeFrame: Day one
measure: Assessment of vision under dim illumination and at night using the Low Luminance Questionnaire
timeFrame: Day one
measure: Relationship between Low Luminance Questionnaire and vision loss
timeFrame: Day one
measure: Relationship between the Low Luminance Questionnaire and the Life Space Questionnaire
timeFrame: Day one
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
Study officials:
affiliation: University of Alabama at Birmingham
name: Lyne Racette, PhD
role: PRINCIPAL_INVESTIGATOR
References: