louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04650308: Sex Differences in Neuropeptide Y Serum, But Not in Fat Intake and Body Mass Index
Official title: Sex Differences in Neuropeptide Y Serum, But Not in Fat Intake and Body Mass Index
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nutrient Deficiency
Keywords: obesity
appetite
neuropeptide
orexigenic
energy
gender
Lead sponsor: Universitas Sumatera Utara
Sponsor class: OTHER
First posted: 2020-12-02
Enrollment: 62
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: One's appetite has a role in controlling food intake and maintaining energy balance, but its effect on body metabolism related to obesity is still questionable. The purpose of this study was to determine the levels of neuropeptide Y in healthy people and to see differences in gender and anthropometric parameters. The hypothesis of this study was that there would be differences in neuropeptide Y levels in groups with gender and anthropometric parameter differences.

Detailed description: One's appetite has a role in controlling food intake and maintaining energy balance, but its effect on body metabolism related to obesity is still questionable. The purpose of this study was to determine the levels of neuropeptide Y in healthy people and to see differences in gender and anthropometric parameters. The hypothesis of this study was that there would be differences in neuropeptide Y levels in groups with gender and anthropometric parameter differences. This study was a cross-sectional study involving 62 study subjects, male and female, who did not have chronic diseases or metabolic disorders. This research was conducted from April to September 2020. The parameters examined in this study were neuropeptide Y levels and anthropometric parameters. The statistical analysis performed was the Mann-Whitney test to see the differences between groups. The mean age of the research subjects was 40.48 ± 10.85 years, with the same ethnic distribution. The distribution of men and women was more women than men. Based on anthropometric examination, it was found that obesity nutritional status was more common in the female group than in the male group; however, serum neuropeptide Y levels were found to be significantly different between male and female groups (male group was higher).

Eligibility criteria: Inclusion Criteria:

* healthy groups for Neuropeptide Y Serum diagnosis

Exclusion Criteria:

* Non-healthy groups for Neuropeptide Y Serum diagnosis

Primary outcomes:
measure: levels of neuropeptide Y
timeFrame: up to 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Medan
country: Indonesia
facility: Faculty of Medicine Universitas Sumatera Utara
state: North Sumatra
Study officials:
References:
Clinical trial NCT02907008: Sleep Quality and Risk of Intubation in Intensive Care Units Patients With Hypoxemic Acute Respiratory Failure
Official title: Sleep Quality and Risk of Intubation in Intensive Care Units Patients With Hypoxemic Acute Respiratory Failure
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sleep Quality
Hypoxemic Acute Respiratory Failure
Intubation Risk
Lead sponsor: Poitiers University Hospital
Sponsor class: OTHER
First posted: 2016-09-20
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: intensive care units patients with hypoxemic acute respiratory failure

Brief summary: The aim of the study is to evaluate the impact of sleep quality on intubation rate in intensive care units patients with acute respiratory failure


Eligibility criteria: Inclusion Criteria:

* Acute respiratory failure
* hypoxemia with PaO2/FiO2 ratio \< 300 mmHg
* aged of 18 years or more

Exclusion Criteria:

* Need of immediate intubation
* Need of vasopressor drugs
* coma with Glasgow scale \< 8
* Acute respiratory failure linked to cardiogenic pulmonary oedema
* Chronic respiratory insufficiency
* Peripheral or central nervous system pathology
* Known psychiatric pathology or agitation
* Patient with decision of no intubation
* Patient refusal
* Pregnant or breastfeeding women
* Patient under legal guardianship or protection
* Patients with no health insurance coverage

Primary outcomes:
measure: to compare the intubation rate of patients with hypoxemic acute respiratory failure between those who have a poor quality of sleep and those who have a good quality of sleep
timeFrame: 24h
Secondary outcomes:
Other outcomes:
Locations:
city: Poitiers
country: France
facility: Chu Poitiers
Study officials:
References:
Clinical trial NCT05943808: Teaching Acupuncture Points With Recorded VR Courses Versus Traditional Text
Official title: Teaching Acupuncture Points With Recorded VR Courses Versus Traditional Text
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Acupuncture Learning
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2023-07-13
Enrollment: 200
Sex: ALL
Minimum age (years): 17
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Mainly bachelor degree students

Brief summary: Compare the learning effectiveness of traditional book learning and VR pre-recorded courses as a reference for future development of VR teaching systems

Detailed description: Traditional Chinese medicine acupuncture education primarily relies on two-dimensional textbooks as the main learning method. Although supplementary materials such as anatomy courses and acupoint anatomy books can partially compensate for the shortcomings of traditional textbooks in anatomical integration, these materials only provide predetermined anatomical views. They make it difficult for students to learn from arbitrary angles and anatomical levels. Therefore, the investigators are developing a Virtual Reality (VR) acupuncture bronze figure model and learning system in an attempt to enhance the depth of acupuncture point learning beyond traditional methods. In this research, the investigators will compare the learning outcomes of traditional book learning and VR pre-recorded courses.

Eligibility criteria: Inclusion Criteria:

1. Individuals who have not previously been exposed to any courses related to Traditional Chinese Medicine acupuncture.
2. Participants who have received an explanation of the research purpose and the entire experimental process, have consented to participate in the study, and have signed an informed consent form.

Exclusion Criteria:

1. Individuals who refuse to sign the informed consent form.
2. The project leader and research advisors.
3. Students who have a direct teaching relationship with the researchers.

Primary outcomes:
measure: Test score change
timeFrame: within singe 1 hour session
Secondary outcomes:
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: China Medical University Hospital
state: North District
Study officials:
References:
Clinical trial NCT01209923: Validation of the Stayhealthy BC1 Body Comp Analyzer
Official title: Validation of the BC1 Bioelectrical Impedance Body Comp Analyzer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Body Composition
Keywords: Percent body fat
Body Composition
Stayhealthy
Lead sponsor: University of Southern California
Sponsor class: OTHER
First posted: 2010-09-27
Enrollment: 362
Sex: ALL
Minimum age (years): 10
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study was to validate the Stayhealthy BC1 bioelectrical impedance analyzer to assess percent body fat in children and adults. The BC1 was compared to dual-energy x-ray absorptiometry assessment of body fat for adults and to hydrostatic weighing assessment of body fat for children. We hypothesized that the BC1 would provide similar measures of body fat between devices with acceptable limits of agreement.

Detailed description: The BC1 body composition analyzer is manufactured by Stayhealthy. It is a handheld, noninvasive bioelectrical impedance device. When held, the BC1 sends an electrical impulse through the body to determine body fat, muscle mass, and body hydration. Bio-impedance devices measure the change in electrical resistance in body tissues by using a detectable electrical signal that passes through the body. The method is based on the principle that lean body mass contains virtually all the water and conducting electrolytes in the body and provides a good electrical pathway. In contrast, fat or fat-containing tissues produce a poor electrical pathway. By inducing a low-energy, high -frequency signal, a measurement of the baseline resistance to flow of electrical current can be assessed. The resistance measurement relates directly to the volume of the conductor. Through repeated measurements and identifying other parameters (i.e. gender, weight, age and height) proprietary equations were developed that determine total body water, fat free body mass, and total body fat.

Eligibility criteria: Inclusion Criteria:

* boys and girls 10-17 yrs and men and women 18-80 yrs

Exclusion Criteria:

* acute illness
* pregnancy
* pacemaker or defibrillator

Primary outcomes:
measure: Percent Body Fat
timeFrame: 2 measures were assessed during a single visit
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: USC Clinical Exercise Research Center
state: California
Study officials:
affiliation: University of Southern California
name: Edward T Schroeder, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Erceg DN, Dieli-Conwright CM, Rossuello AE, Jensky NE, Sun S, Schroeder ET. The Stayhealthy bioelectrical impedance analyzer predicts body fat in children and adults. Nutr Res. 2010 May;30(5):297-304. doi: 10.1016/j.nutres.2010.04.009.
Clinical trial NCT00617123: Trial to Assess the Ocular Safety of Vorapaxar (SCH 530348) in Participants With Atherosclerosis (Study P05183)
Official title: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Ocular Safety of SCH 530348 in Subjects Participating in the Schering-Plough P04737 Study (TRA^SM-Secondary Prevention Ocular Safety Study)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Atherosclerosis
Ischemia
Myocardial Infarction
Cerebrovascular Accident
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
Collaborators: name: The TIMI Study Group
name: Duke Clinical Research Institute
First posted: 2008-02-15
Enrollment: 258
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study is designed to evaluate the long-term ocular safety of SCH 530348 (vorapaxar) in participants with established atherosclerotic disease who are enrolled into the TRA 2°P - TIMI 50 Study (P04737) (NCT00526474).


Eligibility criteria: Inclusion Criteria:

* Evidence or a history of atherosclerosis involving the coronary, cerebral, or peripheral vascular systems

Exclusion Criteria:

* The study will include participants who meet none of the exclusion criteria for the parent protocol (P04737) and also the following:

  * history or evidence of age-related macular degeneration on baseline evaluation
  * history of diabetic macular edema, or evidence of treated diabetic retinopathy on baseline evaluation
  * history or evidence of other retinal diseases, including retinal injury, on baseline evaluation
  * history or evidence of retinal surgery, including laser photocoagulation, on baseline evaluation
  * history or evidence of glaucoma on baseline evaluation
  * history or evidence of high intraocular pressure of \>22 mm Hg on baseline evaluation
  * evidence of center foveal thickness of \>190 µm on baseline OCT examination
  * presence of vacuoles in the retina on baseline OCT

Primary outcomes:
measure: Number of Participants Who Develop Vacuolization in the Inner Nuclear Layer (INL) of the Retina as Measured by Ocular Coherence Tomography (OCT)
timeFrame: Up to 12 months
Secondary outcomes:
measure: Number of Participants Who Have a Decrease in Visual Acuity Score of at Least Seven Letters From Baseline
timeFrame: Baseline and 4, 8 and 12 months
measure: Number of Participants With Change From Baseline of Center Foveal Thickness of Greater Than 15 Microns as Measured by OCT
timeFrame: Baseline and 4, 8 and 12 months
measure: Change From Baseline in the Numerical Score of Graded Abnormalities as Measured by OCT
timeFrame: Baseline and 4, 8 and 12 months
measure: Change From Baseline in the Numerical Score of Graded Abnormalities as Measured by Fundus Photography
timeFrame: Baseline and 4, 8 and 12 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01863823: The Effective Treatment of Oral Helicobacter Pylori With the Success Rate of Gastric Eradication
Official title: Director of Research Division
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Oral Helicobacter Pylori
Keywords: Symptomatic patients
asymptomatic individuals
clinical trial
Lead sponsor: Ameritek USA
Sponsor class: INDUSTRY
First posted: 2013-05-29
Enrollment: 350
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: 1. Gastric eradication has no effective on oral H. pylori infection.
2. Treatment of oral infection increase success rate of eradication on stomach infection.

Detailed description: Objective: The present study was aimed to explore the relationship of Helicobacter pylori(H. pylori) of the oral cavity with the success rate eradication of gastric H. pylori infection.

Study Design and Setting: 202 symptomatic and 148 asymptomatic individuals were recruited and tested using Saliva H. pylori antigen tests (HPS), H. pylori flagellin (HPF), the urea breathe test (UBT) and the polymerase chain reaction (PCR) test. Test subjects also received various treatments.

We collected data of HPS, HPF , PCR and UBT before treatment on 202 symptomatic patients and 148 asymptomatic individual groups. After drug treatment, we run HPS, HPF, PCR and UBT tests. If the tests of HPS, HPF and PCR show negative that indicate success of oral H.pylori eradication. If the test of UBT show negative that indicate success of stomach H.pyloi eradication. We also compare the suceess rate of eradication on stomach infection with and without oral H. pylori infection.

Eligibility criteria: Inclusion Criteria:

* patients with gastrointestinal complaints

Exclusion Criteria:

* patients who had taken any antibiotics and/or proton pump inhibitors within four weeks prior to sample collection

Primary outcomes:
measure: Success Rate
timeFrame: 12 months
Secondary outcomes:
measure: Diagnostic
timeFrame: 6 months
Other outcomes:
measure: Agreement of diagnostic and success rate of gastric eradication
timeFrame: 12 months
Locations:
city: Beijiang
country: China
facility: Beijing University First Hospital
Study officials:
References:
citation: Wang XM, Yee KC, Hazeki-Taylor N, Li J, Fu HY, Huang ML, Zhang GY. Oral Helicobacter pylori, its relationship to successful eradication of gastric H. pylori and saliva culture confirmation. J Physiol Pharmacol. 2014 Aug;65(4):559-66.
Clinical trial NCT03442023: Different Oral Colonization of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine at 0.12% Versus Chlorhexidine at 2.0%
Official title: Differences Between Oral Colonization Rates of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine Mouthwash at 0.12% Versus Chlorhexidine Mouthwash at 2.0%
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Chlorhexidine
Ventilator Associated Pneumonia
Keywords: Chlorhexidine
Gram-negative
Colonization
Lead sponsor: Universidad de Guanajuato
Sponsor class: OTHER
First posted: 2018-02-22
Enrollment: 74
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will assess the utility of different chlorhexidine mouthwash concentrations on ICU patients to decolonize their oral cavities from gram-negative bacteria, since this is a non-desirable condition that leads to higher mortality rates and longer hospitalization times. One group will receive the 0.12% chlorhexidine mouthwash and the other group will receive the 2% chlorhexidine mouthwash.


Eligibility criteria: Inclusion Criteria:

* Patients with minimum required age of consent that were admitted to the intensive care unit and who received at least 48 hours of mechanical ventilation.

Exclusion Criteria:

* Patients who wish to withdraw consent and leave the study.

Primary outcomes:
measure: Gram-negative decolonization rate
timeFrame: 2 weeks
measure: Gram-negative colonization rate
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Leon
country: Mexico
facility: University of Guanajuato
state: Guanajuato
Study officials:
affiliation: Universidad de Guanajuato
name: Jose A Alvarez, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00489723: Is There is a Role of Prophylactic Therapy With Tamsulosin Before Extracorporeal Shock Wave Lithotripsy to Avoid Development of Steinstrasse ?
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Kidney Stones
Keywords: size of stone 1-2 cm
Pt. with no use of alfa bloker prior ESWL
Pt. without internal stent
Lead sponsor: HaEmek Medical Center, Israel
Sponsor class: OTHER
First posted: 2007-06-21
Sex: ALL
Minimum age (years): 15
Maximum age (years): 85
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: DEFINED_POPULATION
Time perspective: PROSPECTIVE

Brief summary: The purpose of this study is to determine if there is a role of prophylactic therapy with tamsulosin prior extracorporeal shock wave lithotripsy to avoid development of steinstrasse. 150 persons that will go to Extracorporeal shock wave lithotripsy will randomize to 2 groups.

Group 1 -of 75 persons will recieve tamsulosin 0.4 mg x 1/d 2 days before the lithotripsy .

Group 2 - of 75 persons will not recieve tamsulosin. 48 hour after the ESWL all 2 group will take abdominal radiograph to evaluate the presence of steinstrasse.


Eligibility criteria: Inclusion Criteria:

* size of stone 1-2 cm

Exclusion Criteria:

* ureteral stricture Presence of internal stent prior use of alfa bloker prior ESWL

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Afula
country: Israel
facility: Haemek medical center
Study officials:
affiliation: Urology department: Haemek Medical Center
name: doron perez
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05251623: Walking Program With Pedometer on Quality of Life in COPD
Official title: The Effect of Walking Program With Pedometer on Quality-of-life Among Chronic Obstructive Pulmonary Disease Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: COPD
pedometer
physical activity
quality of life
Lead sponsor: Chang Gung University
Sponsor class: OTHER
First posted: 2022-02-23
Enrollment: 45
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The aim of this study is to investigate the effects of a walking program on exercise capacity and quality of life in patient with COPD. Method: Patients with COPD were randomly assigned to pedometer group (PG) or control group (CON). Subjects in PG walked to target steps daily with pedometer for 6 weeks. Before and after the program, the following measurements were performed: pulmonary function test (PFT), daily steps, Six-Minute Walk Test (6MWT), COPD Assessment Test (CAT), and quality of life questionnaire (SF-12).

Detailed description: Patients with chronic obstructive pulmonary disease (COPD) are suffered from impaired pulmonary function and dyspnea which result to limited level of physical activity, and impaired quality of life. Exercise and regular physical activity have been proven to break the vicious circle. The aim of this study is to investigate the effects of a walking program on exercise capacity and quality of life in patient with COPD. Method: Patients with COPD were randomly assigned to pedometer group (PG) or control group (CON). Subjects in PG walked to target steps daily with pedometer for 6 weeks. Before and after the program, the pulmonary function was assessed by spiromtery test. The exercise capacity were assessed by six-minute walking test, the physical activity level was assessed by daily steps, The quality of life was assessed by COPD Assessment Test (CAT), and quality of life questionnaire (SF-12).

.

Eligibility criteria: Inclusion Criteria:

1. diagnosed with COPD
2. in a medically stable condition
3. able to walk unassisted
4. ≥ 40 years of age

Exclusion Criteria:

1. oxygen therapy,
2. hemodynamic instability,
3. signs/symptoms of acute infection
4. severe neurological, musculoskeletal, or cardiovascular conditions that affect walking

Primary outcomes:
measure: tidal volume
timeFrame: week 0
measure: tidal volume
timeFrame: week 7
measure: Short-form 12 questionnaire (SF-12)
timeFrame: week 0
measure: Short-form 12 questionnaire (SF-12)
timeFrame: week 7
measure: 6 minute walking test
timeFrame: week 0
measure: 6 minute walking test
timeFrame: week 7
measure: daily steps
timeFrame: week0
measure: daily steps
timeFrame: week 7
Secondary outcomes:
Other outcomes:
Locations:
city: Taoyuan
country: Taiwan
facility: Taoyuan General Hospital
Study officials:
affiliation: Chang Gung University
name: Yen-Huey Chen, PhD
role: PRINCIPAL_INVESTIGATOR
References: