Clinical trial NCT00059462: Safety and Efficacy of BAY 50-4798 in Patients With HIV Infection
Official title: Phase I/II Randomized, Double Blind, Dose Escalation Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of Subcutaneous Bay 50-4798 Administration in Patients With HIV Infection on Highly Active Antiretroviral Therapy (HAART) Compared to Patients on HAART Alone.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: HIV Infections
Keywords: Treatment experienced
Lead sponsor: Bayer
Sponsor class: INDUSTRY
First posted: 2003-06-02
Enrollment: 56
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the safety of the experimental drug Bay 50-4798 in HIV positive patients receiving HAART and to test the drug's effect on the CD4+ T-cell count.


Eligibility criteria: Inclusion Criteria:

* Documented HIV infection (positive enzyme linked immuno assay (EIA) confirmed by Western Blot).
* Age greater than or equal to 18 years.
* Plasma HIV viral load less than 10,000 copies/ml (by bDNA assay or less than 14,000 copies/ml by RT-PCR) on at least 2 occasions within 8 weeks prior to study entry with no more than a 0.5 log increase between the most recent and the earlier viral load measurements.
* CD4 + T-cell count greater than or equal to 200/mm(3) on at least 2 occasions within 8 weeks of study entry.
* On a stable HAART regimen for greater than or equal to 8 weeks.
* Karnofsky Score greater than or equal to 80.
* Written informed consent. Exclusion Criteria:
* Prior treatment with IL-2 or an IL-2 analogue.
* Pregnancy or breastfeeding. - Use of any known immunomodulators, cytokines, growth factors or systemic corticosteroids (e.g. prednisone greater than or equal to 15 mg/day or equivalent) within 4 weeks prior to study enrollment.
* History of an AIDS defining illness by the Centers for Disease Control (CDC) definition within 8 weeks prior to study entry.
* Acute bacterial or viral infection within 4 weeks prior to enrollment.
* Received an immunization within 4 weeks prior to enrollment.
* History of autoimmune disease including psoriasis, inflammatory bowel disease.
* Medical history of transplantation (solid organ or bone marrow).
* Received an investigational drug in the past 30 days other than Food and Drug Administration (FDA) sanctioned treatment IND antiretroviral agents.
* Renal insufficiency with a serum creatinine level greater than 1.5 times the upper limit of normal.
* Bone marrow suppression as defined by one or more of the following: granulocyte count less than 1,000 cells/ÂµL; hemoglobin less than 9.0g (females) or less than 9.5g (males); or platelet count less than 75,000 cells/ÂµL.
* Evidence of hepatic disease indicated by one or more of the following: SGOT (AST) and/or SGPT (ALT) greater than 5 times the upper limit of normal. Bilirubin greater than 2 times the upper limit of normal (except for patients with known Gilbert's syndrome or those receiving indinavir who may be enrolled if the serum bilirubin is less than or equal to 5 times the upper limit of normal).
* Active cardiac disease (coronary artery disease, congestive heart failure or cardiomyopathy) requiring treatment with any of the following medications: antiarrhythmic agents including digitalis, anti-anginal drugs including topical or systemic nitrates, calcium channel blockers, and beta blockers, and afterload reducers including ACE inhibitors. Patients requiring any of these medications solely for the treatment of hypertension remain eligible for the study.
* Presence of significant cardiac insufficiency (greater than or equal to New York Heart Association Grade 2).
* Diagnosis of an active malignancy requiring treatment with systemic cytotoxic chemotherapy.
* Active alcohol or substance abuse which, in the opinion of the investigator, will seriously compromise the subject's ability to adhere with the demands of the study.
* Any central nervous system (CNS) disease that requires active treatment with anticonvulsants.
* Use of an antimetabolite such as hydroxyurea within 4 weeks prior to study entry.
* Known co-infection with Hepatitis B or C virus unless serum transaminases are less than or equal to 2 times the upper limit of normal on at least two occasions within 8 weeks prior to study entry.
* Known CD4 Nadir less than 50 cells/mm(3).

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United States
state: Alabama
city: Davis
country: United States
state: California
city: Los Angeles
country: United States
state: California
city: Palo Alto
country: United States
state: California
city: San Francisco
country: United States
state: California
city: Chicago
country: United States
state: Illinois
city: Chicago
country: United States
state: Illinois
city: Bethesda
country: United States
state: Maryland
city: Cleveland
country: United States
state: Ohio
city: Creteil
country: France
city: London
country: United Kingdom
state: Greater London
Study officials:
affiliation: Bayer
name: Bayer Study Director
role: STUDY_DIRECTOR
References: