louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06583681: Shape of the Sagittal Curvatures of the Spine in Youthful Female Volleyball Players
Official title: Shape of the Sagittal Curvatures of the Spine in Youthful Female Volleyball Players
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Sport
Training
Kyphosis
Lordosis
Health
Lead sponsor: University of Rzeszow
Sponsor class: OTHER
First posted: 2024-09-04
Enrollment: 60
Sex: FEMALE
Minimum age (years): 10
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The goal of this study is to assess the formation of the sagittal curvatures of the spine in healthy girls practicing volleyball versus their untrained peers.

Research questions:

1. Is there a differentiation in values of thoracic kyphosis, lumbar lordosis angles, and compensation ratio among girls practicing volleyball and their untrained peers?
2. Does practicing volleyball determine the frequency of correctness in the lumbosacral inclination, the shape of the curvature of the thoracic kyphosis and lumbar lordosis?
3. Does practicing volleyball determine the frequency of types and subtypes of body posture?

Detailed description: The investigators compared 30 healthy girls aged 10-13 (attending training regularly, three times a week), with 30 healthy peers who did not train in any sports and did not regularly participate in any physical exercises apart from attending obligatory physical education classes. The Baseline Bubble inclinometer was applied as the research tool of choice. The study protocol entailed the measuring of the sagittal curvatures of the spine.

Eligibility criteria: Inclusion Criteria:

* age range of 10-13 years,
* dominating right hand and right leg,
* a written informed consent to participate in the study.

Exclusion Criteria:

* injuries of the musculoskeletal system,
* pathology of the limbs,
* previous orthopedic surgery,
* neurological disorders,
* refusal to participate in the study.

Primary outcomes:
measure: Number of participants who experienced abnormalities resulting from sports training according to inclinometer assessment
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Rzeszów
country: Poland
facility: University of Rzeszow
Study officials:
affiliation: University of Rzeszow
name: Ewa Puszczalowska-Lizis
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01078181: Banded Versus Non-banded Roux-en-Y Gastric Bypass
Official title: A Prospective Randomized Comparison on Weight Loss After Gastric Bypass and Banded Gastric Bypass Using the A.M.I B-Band (Soft Gastric Bypass Band)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Morbid Obesity
Keywords: gastric bypass
banded gastric bypass
weight loss
weight regain
bariatric surgery
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2010-03-02
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a prospective randomized Study comparing Weight loss, Esophageal Motility and Reflux in lap. Gastric Bypass vs. lap. Banded-Gastric Bypass using the A.M.I. Soft Gastric Bypass Band (B-Band.


Eligibility criteria: Inclusion Criteria:

* BMI \> 40 or BMI \> 35 + hypertension/diabetes mellitus
* pH metry and manometry preoperatively

Exclusion Criteria:

* formerly operations of the stomach
* formerly open abdominal surgery
* malignancy within the last 5 years
* formerly gastric banding

Primary outcomes:
measure: Excessive Weight Loss
timeFrame: 3 years
Secondary outcomes:
measure: pouch dilatation, band migration, reflux, esophageal motility
timeFrame: 3 years
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Medical University of Vienna, Department of Surgery
Study officials:
affiliation: Medical University of Vienna, Department of Surgery
name: Gerhard Prager, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01297881: Belgian Pulmonary Function Study
Official title: Belgian Pulmonary Function Study : the Belgian Thoracic Society
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Respiratory Symptoms
Keywords: Caucasian outpatients
undiagnosed respiratory symptoms
dyspnea
cough
sputum
Lead sponsor: KU Leuven
Sponsor class: OTHER
Collaborators: name: Belgian Pulmonary Society
First posted: 2011-02-17
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Caucasian outpatients with respiratory symptoms but without diagnosis

Brief summary: Pulmonary function tests including spirometry, lung volumes, measurements of resistance and diffusing capacity are essential in the diagnosis of several pulmonary diseases. These tests are an integral part of the diagnosis and treatment of lung diseases, but until now there is no clear evidence for the use of many of the pulmonary function tests because of a lack of adequate studies. The obscurity largely pertains to the conditions under which combinations of the various tests are indicated. Therefore the Belgian Thoracic Society, assembling all pulmonologists and the pneumology LOK/GLEM"s, will investigate this matter.


Eligibility criteria: Inclusion Criteria:

* Males and females
* Age between 18 and 75 years old
* New outpatients with respiratory symptoms as dyspnoea, cough, sputum, but without firm diagnosis
* Results of the tests are available and acceptable
* Standardized list of complaints
* Capability of patient for doing pulmonary function tests
* Seen by a Pneumologist
* Written informed consent

Exclusion Criteria:

* Patients with diagnosed respiratory disease
* Younger than 18 and older than 75 years old
* Recent heart attack
* Pneumothorax
* hemoptoic
* Suspicion of Tuberculosis
* Not capable to do pulmonary function tests

Primary outcomes:
measure: pulmonary function tests (spirometry, volumes, resistance and diffusing capacity in that order) on the preferential diagnosis.
timeFrame: end of study
Secondary outcomes:
measure: % correct preferential diagnoses
timeFrame: end of study
measure: N differential diagnoses in the subgroup with correct preferential diagnosis
timeFrame: end of study
measure: subgroup analyses
timeFrame: end of study
measure: Sensitivity analysis
timeFrame: end of study
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: University Hospital Leuven
state: Flanders
Study officials:
affiliation: Universitaire Ziekenhuizen KU Leuven
name: Marc MD Decramer, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Decramer M, Janssens W, Derom E, Joos G, Ninane V, Deman R, Van Renterghem D, Liistro G, Bogaerts K; Belgian Pulmonary Function Study Investigators. Contribution of four common pulmonary function tests to diagnosis of patients with respiratory symptoms: a prospective cohort study. Lancet Respir Med. 2013 Nov;1(9):705-13. doi: 10.1016/S2213-2600(13)70184-X. Epub 2013 Oct 4.
Clinical trial NCT03060681: Thoracolumber Oterfacial Plane Block for Spine Surgery
Official title: Thoracolumbar Interfacial Plane Block for Analgesia After Spine Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Spine Surgeries
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2017-02-23
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The most commonly used technique to anesthetize patients scheduled for thoracic or lumbar spine surgery is general anesthesia. Analgesic techniques vary from the use of neuraxial techniques like epidural, intrathecal, or caudal analgesia, nerve root infiltration to the use of systemic opioids, Paracetamol, non-steroidal anti-inflammatory drugs (NSAID), steroids and gabapentinoids .

In 2015, a promising regional analgesia technique was reported, that targets the dorsal, rather than ventral, rami of the thoracolumbar nerves as they pass through the paraspinal musculature, and called this a thoracolumbar interfacial plane block (TLIP).


Eligibility criteria: Inclusion Criteria:

* Patients scheduled for Spine surgery.

Exclusion Criteria:

* Spine deformities, redo surgeries, patients refusing being enrolled in the study, and patients with a bleeding tendency (INR˃ 1.4 and or Platelet count ≤ 150 X103/ µl) will be excluded.

Primary outcomes:
measure: postoperative morphine consumption in milligrams
timeFrame: for the 1st 24 hours after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mansoura university
state: Dakahleya
Study officials:
References:
Clinical trial NCT01747395: Exercise Training Associated With Inspiratory Muscle Training in Heart Failure
Official title: Effects of Aerobic Exercise Training Associated With Inspiratory Muscle Training in Patients With Heart Failure
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Heart Failure
Keywords: Heart Failure
Exercise and Physical Fitness
Lead sponsor: University of Sao Paulo General Hospital
Sponsor class: OTHER
Collaborators: name: Federal University of São Paulo
First posted: 2012-12-11
Enrollment: 40
Sex: ALL
Minimum age (years): 30
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators hypothesize that aerobic exercise training associated with respiratory muscle training will cause additional benefits compared to isolated exercise training or respiratory training in chronic heart failure patients.

Detailed description: The investigators hypothesize that aerobic exercise training associated with respiratory muscle training will cause additional benefits in the autonomic control and respiratory function compared to isolated exercise training or respiratory training in chronic heart failure patients.

Eligibility criteria: Inclusion Criteria:

* Patients with systolic heart failure and New York Heart Association (NYHA) class II-III
* Left ventricular ejection fraction less than 40%
* Peak Oxygen Consumption less than 20 ml/Kg/min

Exclusion Criteria:

* Chronic Obstructive Pulmonary Disease
* Neuromuscular, Orthopedic, Neurologic and Neoplastic Diseases
* Recent myocardial infarction or cardiac surgery (less than 6 months)
* Unstable angina pectoris
* Atrial Fibrillation
* Pacemakers users
* Actual Smoker
* Pregnant
* Changing medication or hospital admission

Primary outcomes:
measure: Autonomic control
timeFrame: 4 months
Secondary outcomes:
measure: Functional Capacity
timeFrame: 4 months
measure: Quality of life
timeFrame: 4 months
measure: Blood inflammatory markers
timeFrame: 4 months
measure: Muscular evaluation
timeFrame: 4 months
measure: Respiratoy muscle function
timeFrame: 4 months
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Instituto do Coração - HC/FMUSP
state: SP
Study officials:
affiliation: InCor, HCFMUSP
name: Carlos Eduardo Negrão
role: PRINCIPAL_INVESTIGATOR
References:
citation: Antunes-Correa LM, Trevizan PF, Bacurau AVN, Ferreira-Santos L, Gomes JLP, Urias U, Oliveira PA, Alves MJNN, de Almeida DR, Brum PC, Oliveira EM, Hajjar L, Kalil Filho R, Negrao CE. Effects of aerobic and inspiratory training on skeletal muscle microRNA-1 and downstream-associated pathways in patients with heart failure. J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):89-102. doi: 10.1002/jcsm.12495. Epub 2019 Nov 19.
Clinical trial NCT04249895: Comprehensive Digital Archive of Cancer Imaging-Radiation Oncology( CHAVI-RO )
Official title: Comprehensive Digital Archive of Cancer Imaging-Radiation Oncology( CHAVI-RO )
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: All Cancer
Keywords: Carcinoma
Radiomics
Image Processing
Radiology
Molecular Biology
Data Analytics Center
Artificial Intelligence
Medical Physics
Big Data
Radiation Oncology
Lead sponsor: Tata Medical Center
Sponsor class: OTHER
First posted: 2020-01-31
Enrollment: 500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All Patients undergoing radiotherapy in the dept of radiotherapy, Tata Medical Center.

Brief summary: In this pilot project Investigators propose to create annotated image data bank of patients suffering from cancer. The system will provide India's first comprehensive platform to upload annotated images with associated medical and demographic information of a patient. It will support flexible query from the users with appropriate choice from a set of attributes and design of various query filters using a GUI. Over the proposed period of 18 months, images and records related to radiation oncology including pretreatment images of at least 500 patients would be annotated and archived in the data bank. The imaging modalities to be covered are X-RAY mammograms, SPECT, CT, CBCT, MR, PET-CT, Ultrasound, digital histopathology, etc. In this phase, this study will include data sets of five types of cancers namely, breast, head and neck, brain, cervix and lung cancer.

Investigator propose to demonstrate the application of this data set in cancer research. Investigator will work on serial PET-CT based radiomics of breast and cervix cancer patients to extract appropriate features and correlate them with clinico-pathological variants.


Eligibility criteria: Inclusion Criteria:

1. Patients undergoing radiotherapy planned with volumetric imaging.

-

Exclusion Criteria:

* Informed Consent not given

Primary outcomes:
measure: Number of patients with complete data safe.
timeFrame: 18 months
Secondary outcomes:
Other outcomes:
Locations:
city: Kolkata
country: India
facility: Sanjoy Chatterjee
state: West Bengal
Study officials:
References:
Clinical trial NCT00833495: Evaluation of Efficacy of Coadministration of FOV1101-00 and Prednisolone Acetate in Patients With Mild Ongoing Ocular Allergic Inflammation
Official title: A Multi-Center, Randomized, Double-Masked Evaluation of the Efficacy of Co-Administration of FOV1101-00 (Cyclosporine 0.01% or 0.02%) and Prednisolone Acetate 0.12% (PredMild®) Compared to Prednisolone Acetate 1% Alone or Vehicle Alone in Patients With Mild Ongoing Ocular Allergic Inflammation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Allergic Conjunctivitis
Lead sponsor: Fovea Pharmaceuticals SA
Sponsor class: INDUSTRY
First posted: 2009-02-02
Enrollment: 155
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: This is a phase 2 study that will consist of 3 visits during a 3 week period conducted at up to 5 sites. The purpose of this study is to determine how effective the combination of Pred Mild® and FOV1101-00 is compared to either Pred Forte® alone or to vehicle alone in the prevention of eye allergies. Study subjects will be randomized to one of the following:

* FOV1101-00 concentration 1 and Pred Mild®
* FOV1101-00 concentration 2 and Pred Mild®
* Vehicle of FOV1101-00 and Pred Forte®
* Vehicle of FOV1101-00 and Vehicle of FOV1101-00


Eligibility criteria: Inclusion Criteria:

* history of ocular allergies and a positive skin test reaction to allergens within the past 24 months and a history of chronic eye irritation;

Exclusion Criteria:

* active ocular infection; clinically significant blepharitis; follicular conjunctivitis; iritis; any type of glaucoma; ocular surgery within past 3 months; pregnancy or nursing

Primary outcomes:
measure: Ocular Allergic signs and symptoms Diary Scores
timeFrame: Between V2 and V3
Secondary outcomes:
measure: Various ocular and nasal allergic diary scores
timeFrame: Between V2 and V3
Other outcomes:
Locations:
city: Andover
country: United States
facility: Ora
state: Massachusetts
Study officials:
affiliation: Fovea Pharmaceuticals SA
name: Jean-Philippe Combal, PharmD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03865095: Muscle Mass Loss in Critically Ill Patients.
Official title: Muscle Mass Loss in Critically Ill and Its Risk Factors. A Prospective Observational Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Muscle Loss
Keywords: Critical Care
Muscle loss
Rectus femoris cross sectional area
Muscle ultrasound
Lead sponsor: Masaryk University
Sponsor class: OTHER
Collaborators: name: Brno University Hospital
First posted: 2019-03-06
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Critically ill adult patients admitted to intensive care unit with suspect length of artificial ventilation more than 48 hours.

Brief summary: The purpose of the study is to describe the change in muscle mass in critically ill patients. The study will examine rectus femoris cross sectional area with ultrasound and identify risk factors of this changes.

Detailed description: The study will commence following the Approval by The Ethics Research Committee. All patients admitted to our ICU from the 1st of March 2019 to the 31st of August 2019 will be enrolled after fulfilling the inclusion criteria and in the absence of any exclusion criteria. Informed consent will be requested. Ultrasound measurement of rectus femoris cross sectional area will be performed in first 24 hours after admission to ICU.

Study data will be entered in study form. The ultrasound measurement will be repeated on day 7 of hospitalisation.

Changes in rectus femoris cross sectional area and potential risk factors will be analysed. The length of ICU length of stay and 28-day mortality will be also monitored.

Eligibility criteria: Inclusion Criteria:

* age ≥18 years
* mechanical ventilation expected for at least 48 hours

Exclusion Criteria:

* Clinical Frailty Score above 7 prior admission
* neuromuscular disease in previous medical history
* amputated lower extremities
* trauma of lower extremities involving tights
* age under 18 years
* inability to perform ultrasound examination
* death or discharge prior completion of protocol
* full verticalization prior completion of protocol

Primary outcomes:
measure: Muscle mass loss
timeFrame: 7 days
Secondary outcomes:
measure: 28 day mortality
timeFrame: 28 days after enrolment
Other outcomes:
Locations:
city: Brno
country: Czechia
facility: University Hospital Brno and Masaryk University Brno
Study officials:
affiliation: University Hospital Brno and Masaryk University
name: Roman Gal, M.D., PhD.
role: STUDY_CHAIR
References:
Clinical trial NCT04334395: A Retrospective Cohort Study Outcome of Treatment in Asymptomatic Stage 4 Colorectal Cancer
Official title: A Retrospective Cohort Study Outcome of Treatment in Asymptomatic Stage 4 Colorectal Cancer : Primary Tumor Resection vs. No Primary Tumor Resection
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stage IV Colon Cancer
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2020-04-06
Enrollment: 135
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Medical records of stage IV colorectal cancer with unresectable distant metastasis received treatment in Ramathibodi hospital between 1 September 2006 - 31 August 2016.

Brief summary: In asymptomatic Stage 4 colorectal cancer, the treatment varies between many hospitals and countries. Some studies found that primary tumor resection had better survival rates and a lower risk of mortality. But many studies found significant benefits in survival in sub groups of the population such as age less than 70 years, WHO performance status \<2, no extra-hepatic metastasis, liver tumor burden \<50%. However some studies showed no survival benefits in primary tumor resection. So this study will focus on survival, adverse events, complications in primary tumor resection and no primary tumor resection in asymptomatic Stage 4 colorectal cancer.

Detailed description: The retrospective study of patients in asymptomatic Stage 4 colorectal cancer received treatment at Ramathibodi Hospital and excluded symptomatic primary tumors such as obstruction, perforation that required surgery, carcinomatosis peritoneii, and patients with secondary cancer diagnosis in the past 5 years.

Eligibility criteria: Inclusion Criteria:

* Asymptomatic stage IV colorectal cancer
* pathological prove adenocarcinoma
* age \>18 years
* no primary tumor related symptom
* ECOG performance status \<2

Exclusion Criteria:

* symptomatic primary tumor such as obstruction , perforation that required surgery
* carcinomatosis peritoneii
* patients with secondary cancer diagnosis in 5 years

Primary outcomes:
measure: Complication rate
timeFrame: 5 year
Secondary outcomes:
measure: The survival time
timeFrame: 5 year
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Chairat Supsamutchai
state: Bankok
Study officials:
affiliation: 270, Rama VI road, Ratchathevi, Deapartment of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 10400
name: Chairat Supsamutchai, MD
role: STUDY_CHAIR
References: