louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT07020208: Ovice Nurse Transition Shock and Readiness
Official title: Novice Nurses Preparation for Clinical Practice: Examining the Impact of Transition Shock Readiness Skills on Career Entrenchment, and Interprofessional Readiness
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Nurses
Keywords: Novice Nurses Newly Graduated Nurses Transition to Practice Transition Shock Clinical Practice Readiness
Lead sponsor: Port Said University
Sponsor class: OTHER
First posted: 2025-06-13
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: open-label, two-arm Randomized Control Trail (RCT)
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study aims to investigate the impact of a transition shock program on career entrenchment and readiness for interprofessional learning among newly graduated nurses.

Detailed description: This study aims to investigate the impact of a transition shock program on career entrenchment and readiness for interprofessional learning among newly graduated nurses.

Hypotheses:

H1: After the intervention, the study group will report significantly lower transition shock scores compared to the control group.

H2: After the intervention, the study group will report significantly lower career entrenchment scores compared to the control group.

H3: After the intervention, the study group will report significantly higher readiness for interprofessional learning scores compared to the control group.

H4: There will be a significant interaction effect between time (pre-test vs. post-test) and group (study vs. control), where the study group will show greater improvement in readiness for interprofessional learning and greater reduction in transition shock and career entrenchment compared to the control group.

Eligibility criteria: Inclusion Criteria:

* 1. Newly employed nurses who have worked for less than six months in the profession.

  2. Nurses who have not received prior transition-related training before participation in the study.

  3. Nurses willing to participate voluntarily and provide informed consent.

Exclusion Criteria:

1. Nurses with previous work experience before their current job.
2. Those who decline participation or withdraw from the study.
3. Nurses enrolled in ongoing professional development programs related to transition or interprofessional education.

Primary outcomes:
measure: Transition Shock Readiness skills of nurses
timeFrame: 3 monthes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05354908: Surgical Research in Colombia Part 1
Official title: Surgical Research in Colombia Part 1: Scientific and Academic Productivity of the Colombian Research Groups in Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Academic Productivity
Research Productivity
Lead sponsor: Colombian Surgery Association
Sponsor class: OTHER
First posted: 2022-05-02
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Research groups recognized and/or categorized by the Colombian Ministry of Science

Brief summary: Global surgery has become the undisputed starting point for addressing a myriad of problems in surgery today. Therefore, it is necessary to constantly evaluate the scientific productivity in surgery, its behavior, validity and impact. In Latin America, specifically in Colombia, there are no studies that have analyzed this production. A retrospective cross-sectional bibliometric study was carried out, in which the Colombian Ministry of Science database was consulted with the validated results up to July 2021. In the search section for research groups, the keyword "Surgery" was used, and all associated Groups in Latin America and the Caribbean(platform where the information of the research groups can be found) and their registered products were reviewed


Eligibility criteria: Inclusion Criteria:

* Research groups with a main or secondary line of research in general or subspecialty surgery, registered in the base of the Colombian Ministry of Science

Exclusion Criteria:

* Research groups with other lines of research in the surgical sciences

Primary outcomes:
measure: Number of articles published in journals indexed in SJR, Scopus or JCR
timeFrame: 1 year
measure: Quartile of journals in which the articles registered in the database were published
timeFrame: 1 year
Secondary outcomes:
measure: Graduate students' theses supervised by the research group
timeFrame: 1 year
measure: Type of graduate students' theses supervised by the research group
timeFrame: 1 year
measure: Frequency of attendances and presentations at scientific events
timeFrame: 1 year
measure: Type of participation in scientific events in medicine
timeFrame: 1 year
measure: Research projects registered by the research group
timeFrame: 1 year
measure: Type of research projects registered by the research group
timeFrame: 1 year
measure: Book chapters published by the research group to date
timeFrame: 1 year
measure: Books published by the research group to date
timeFrame: 1 year
Other outcomes:
Locations:
city: Bogotá
country: Colombia
facility: Colombian Ministry of Science Database
Study officials:
References:
Clinical trial NCT03012308: Trans-thoracic Ultrasound VS Invasive Pressure of the Left Atrium
Official title: Evaluation of Left Ventricular Filling Pressures in Post-operative Cardiac Surgery: Trans-thoracic Ultrasound VS Invasive Pressure of the Left Atrium
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Myocardial Dysfunction
Keywords: Myocardial Dysfunction
left ventricular
mitral valve doppler
mitral ring doppler
ultrasound signs
lung edema
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2017-01-06
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient hospitalized in surgical resuscitation for cardiac surgery with heart-lung bypass machine, aged over 18 years

Brief summary: As part of cardiac and hemodynamic evaluation of patients, echocardiographic measurements allow indirect evaluation of left ventricular filling pressures (LVFP). These ultrasound parameters, including mitral valve doppler and mitral ring doppler (in particular the E / E 'ratio), are well validated in medical cardiology and in some resuscitation patients. The measurement of filling pressures is an important daily element in the medical management of patients in intensive care, in particular on the hemodynamic and respiratory levels. No studies have evaluated the relevance of these markers in a postoperative context of cardiac surgery. Indeed, the surgery alters the cardiac function, which could modify the values of the echocardiographic parameters and their predictability. Left atrium pressure (LAP) directly reflects LVFP and is measured in cardiac surgical resuscitation by a surgically placed catheter as part of routine institutional care and will serve as gold-standard. To study the clinical significance of these LAP and LVFP values estimated by cardiac ultrasound, we will study their correlation with clinical and ultrasound signs of acute lung edema (ALE).


Eligibility criteria: Inclusion Criteria:

* Patient hospitalized in surgical resuscitation for cardiac surgery with heart-lung bypass machine

Exclusion Criteria:

* No consent
* Mitral valve surgery
* severe MI / severe mitral narrowing.
* Absence of POG catheter
* Urgent surgery
* Heart transplant / mechanical assistance
* Classics: minors, pregnant women, guardianship / curatorship / safeguarding,

Primary outcomes:
measure: Compare the mean values of LAP between the group "high filling pressures" and the group "non-high filling pressures"
timeFrame: 6 postoperative hours of cardiac surgery of patients hospitalized in surgical resuscitation
Secondary outcomes:
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: Service Réanimation chirurgicale cardio-vasculaire - NHC
Study officials:
affiliation: University Hospital, Strasbourg, France
name: Gharib AJOB, MD
role: STUDY_DIRECTOR
affiliation: University Hospital, Strasbourg, France
name: Paul-Michel MERTES, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00347308: Photographic Assessment of Eyebrow Position and Range of Motion
Official title: Photographic Assessment of Eyebrow Position and Range of Motion
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Brow Ptosis
Keywords: brow ptosis, facial aesthetics, browlift, facelift
Lead sponsor: The New York Eye & Ear Infirmary
Sponsor class: OTHER
First posted: 2006-07-04
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults, between the ages of 18- 85

Brief summary: Forehead and eyebrow surgery is a frequently performed cosmetic surgical procedure in which the eyebrows are raised to a more aesthetically pleasing position. Typically, this position is judged by the surgeon pre-operatively based on traditional aesthetic concepts, some of which date to the Classical era. This study is designed to assess the variance of the eyebrow from the desired aesthetic position (as determined by the subject), as wel as to assess the distance of normal excursion of the brow from maximum voluntary depression to maximum voluntary elevation.

Detailed description: A set of 5 digital photographs will be taken of 100 (30 male, 70 female) adult study participants. Prior to photography, water soluble ink will be used to mark the inferior aspect of the superior orbital rim above the medial and lateral canthi and in the mid pupillary line. Photographs taken will image patients from crown to chin and will be taken with eyes open and closed, brows raised, maximally contracted and at rest. A final photograph will be taken with the subject manually holding both brows in the position he/she finds most aesthetically pleasing as seen in a mirror. During all photography, a ruler will be held against the face for later calibration, all photographs will be taken with a camera mounted flash and with the patient in a Frankfort horizontal plane. All photographs will be analyzed with proprietary computer software.

Eligibility criteria: Inclusion Criteria:

* adults,
* aged 18-85 years

Exclusion Criteria:

* prior forehead, eyebrow or eyelid surgery,
* neurotoxin treatment to the forehead or eyes within the past 6 months,
* injectable soft tissue filler used within the last 12 months,
* photosensitivity.

Primary outcomes:
measure: Eyebrow Position
timeFrame: At time of evaluation
Secondary outcomes:
Other outcomes:
Locations:
city: Chappaqua
country: United States
facility: Center for Facial Plastic Surgery
state: New York
Study officials:
affiliation: The New York Eye & Ear Infirmary
name: Anthony P Sclafani, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Sclafani AP, Jung M. Desired position, shape, and dynamic range of the normal adult eyebrow. Arch Facial Plast Surg. 2010 Mar-Apr;12(2):123-7. doi: 10.1001/archfacial.2010.17.
Clinical trial NCT06738108: EKOS in Patients With Pulmonary Embolism (PE)
Official title: Safety and Effectiveness of EKOS in PE Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pulmonary Embolism
Keywords: ECOS
Lead sponsor: Beni-Suef University
Sponsor class: OTHER
First posted: 2024-12-17
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Submassive PE was defined as having right ventricular (RV) dysfunction: detected via CT scan or echocardiography, with signs such as RV enlargement, RV hypokinesis, or RV/LV ratio \>0.9 to 1.0), elevated cardiac biomarkers like troponin or BNP, which indicate strain or injury to the heart muscle with a maintained blood pressure (SBP equal to or \> 90 mm Hg with no signs of shock.

Massive PE was defined as SBP \<90 mm Hg for at least 15 minutes or require vasopressors to maintain adequate blood pressure with clinical signs of poor perfusion, including altered mental status, cool extremities, low urine output, or sudden loss of heart function due to obstructed blood flow from the pulmonary artery.

Brief summary: A retrospective cohort study assessed patients who underwent EKOS intervention following the failure of initial therapeutic anticoagulation for managing acute pulmonary embolism at a tertiary hospital.

Detailed description: A retrospective cohort study assessed patients who underwent EKOS intervention following the failure of initial therapeutic anticoagulation for managing acute pulmonary embolism at a tertiary hospital. Patients aged at least 18 years with a diagnosis of submassive or massive acute PE were included. Patients were excluded if they either did not receive EKOS intervention or were presented with stable PE. The primary outcome was the change in RV/LV diameter ratio from baseline to first outpatient follow-up.

Eligibility criteria: Inclusion Criteria:

* Patients ≥ 18 years diagnosed with massive or submassive acute PE.

Exclusion Criteria:

1. Patients presented with stable PE
2. Patients did not receive EKOS intervention.

Primary outcomes:
measure: The change in RV/LV diameter ratio
timeFrame: one month
Secondary outcomes:
measure: All-cause 30-day readmission
timeFrame: one month
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Saudi German Hospital
Study officials:
References:
Clinical trial NCT05856708: CNS Involvement in Primary Mediastinal Large B-Cell Lymphoma (PMLBCL)
Official title: Retrospective Multicenter International Study on Prognostic Factors, Management And Outcome Of Primary Mediastinal Large B-Cell Lymphoma (PMLBCL) Patients With Central Nervous System (Cns) Involvement.
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Primary Mediastinal Large B-cell Lymphoma (PMBCL)
Keywords: PMLBCL
CNS
Lead sponsor: IRCCS San Raffaele
Sponsor class: OTHER
First posted: 2023-05-12
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients whose diagnosis met the histological criteria of PMLBL according WHO classification with a diagnosis of CNS involvement at relapse/progression. Patients eligible to the study will be retrospectively identified by the site researches by interrogating the local site sources. Availability of local pathological report at time of diagnosis and restaging will be considered for eligibility.

Brief summary: This is a retrospective, multicenter study designed to collect data on the diagnostic, therapeutic management and outcome of patients diagnosed with primary mediastinal lymphoma who have progressed or relapsed with central nervous system (CNS) involvement.

Through this study, an international data set from 6 different countries will be collected on clinical factors, anti-lymphoma therapy administered alone or in conjunction with CNS prophylaxis, re-biopsy site information when available, dose intensity of lymphoma therapy received at recurrence, and patient outcome.

In addition, to better characterize the pathologic features of this rare entity, a central pathologic review of the initial diagnosis and, if available, histologic confirmation of recurrence will be performed.


Eligibility criteria: Inclusion Criteria:

To be eligible for inclusion each patient must fulfil all of the following criteria:

1. Histologically confirmed diagnosis of Primary Mediastinal Large B Cell Lymphoma (PMLBCL) according WHO Classification
2. Had a recurrence/progression with Central Nervous System (CNS) involvement
3. Availability of details on clinical presentation, treatment details and outcome
4. Availability of details on pathological data for central review
5. Age ≥18 years

Exclusion Criteria:

* Patients with CNS lymphoma other than PMLBCL subtype

Primary outcomes:
measure: PT CHARACTERISTICS
timeFrame: 2003-2020
measure: CNS RELAPSE
timeFrame: 2003-2020
measure: PROGNOSTIC FACTORS
timeFrame: 2003-2020
measure: TREATMENT STRATEGY
timeFrame: 2003-2020
measure: PFS
timeFrame: 2003-2020
measure: OS
timeFrame: 2003-2020
measure: MOLECULAR DIAGNOSTIC
timeFrame: 2003-2020
Secondary outcomes:
Other outcomes:
Locations:
city: Milan
country: Italy
facility: IRCCS Ospedale San Raffaele
Study officials:
References:
Clinical trial NCT01093508: Single-dose Safety Study of APD916 in Healthy Volunteers
Official title: Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Dose Escalation Study to Assess the Tolerability and Pharmacokinetics of APD916 Administered to Healthy Adult Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Narcolepsy With or Without Cataplexy
Lead sponsor: Arena Pharmaceuticals
Sponsor class: INDUSTRY
First posted: 2010-03-26
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Primary purpose: TREATMENT

Brief summary: The APD916-001 study is designed primarily to evaluate the safety and tolerability of APD916 when administered as a single dose

Detailed description: This is a Phase 1, randomized, double-blind, placebo-controlled, single-dose escalation study of up to 9 dose cohorts (1, 2, 5, 10, 20, 30, 45, 70 and 90 mg) each comprising 8 subjects (2 to receive placebo, 6 to receive APD916). Each cohort will be assigned to receive a single dose of APD916. After dosing within the first cohort has been completed and safety data review identifies no tolerability issues, and the principal investigator (PI) and Sponsor have agreed that it is safe to proceed, then subjects in the next cohort may be dosed.

Eligibility criteria: Inclusion Criteria:

* Healthy males or females ages 18-45 years
* Body weight of 50-100 kg (110-220 pounds)
* Eligible female subjects will be non-pregnant, evidenced by a negative serum pregnancy test at Screening and a urine dipstick pregnancy test on Day -1 (Check-In); non-lactating; surgically sterile, postmenopausal, or agree to continue to use a medically accepted method of birth control during and for at least 1 month after last study medication administration.
* Eligible male subjects will either be surgically sterile (i.e., vasectomy), for at least 3 months prior to screening, or agree to use a condom with spermicide when sexually active with a female partner who is not using an acceptable method of birth control during the study and for 1 month after.

Exclusion Criteria

* Subject who has donated any blood, or had significant blood loss within 56 days of dosing
* History of smoking or tobacco use within 3 months prior to dosing
* History of epilepsy or other seizure disorder
* Recent history (within 2 years prior to the screening visit) of sleep disorders
* History (within 2 years prior to the screening visit) of ADD or ADHD
* Traveled across more than 3 time zones within 2 weeks prior to dosing

Primary outcomes:
measure: To evaluate the safety and tolerability of single, escalating doses of APD916 when administered to healthy adult subjects
timeFrame: Single dose
Secondary outcomes:
measure: To assess the pharmacokinetic properties of single, escalating doses of APD916
timeFrame: Single dose
Other outcomes:
Locations:
city: Cincinnati
country: United States
facility: Community Research
state: Ohio
Study officials:
affiliation: Community Research, Cincinnati, OH
name: James Maynard, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04750408: NHF vs. COT in Hypoxemic Pandemic Viral Illness
Official title: Clinical Effects of Nasal High-flow Compared to Oxygen in Acute Viral Illness
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Acute Viral Bronchitis
Hypoxemic Respiratory Failure
Hypercapnic Respiratory Failure
Lead sponsor: Klinikum Emden
Sponsor class: OTHER
First posted: 2021-02-11
Enrollment: 52
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.


Eligibility criteria: Inclusion Criteria:

* acute hyperemic viral illness
* acute hyperemic or hypercapnia respiratory failure

Exclusion Criteria:

* intubation criteria
* indication for NIV therapy
* influences of primary endpoint (rip fracture, lung embolism)
* tracheostomy
* other interventional trials
* noncompliance

Primary outcomes:
measure: Rox index
timeFrame: 72 hours
Secondary outcomes:
measure: paCO2 in mmHg
timeFrame: 72 hours
measure: pH
timeFrame: 72 hours
measure: escalation of therapy
timeFrame: 72 hours
measure: paO2 in mmHg
timeFrame: 72 hours
Other outcomes:
Locations:
city: Emden
country: Germany
facility: Klinikum Emden
Study officials:
affiliation: chair
name: Jens Bräunlich, MD
role: STUDY_CHAIR
References: