louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04204681: Tonsillar Retractor-induced Subacute Submassive Tongue Edema
Official title: Tonsillar Retractor-induced Subacute Submassive Tongue Edema: A New Cause of Late Respiratory Complications in Pediatric Patients Undergoing Tonsillectomy and a Condition Detected by Ultrasonography
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Side Effects
Tonsil Hypertrophy
Children, Only
Keywords: ultrasonography
children
tonsil
diagnostic imaging
Lead sponsor: Selcuk University
Sponsor class: OTHER
First posted: 2019-12-19
Enrollment: 61
Sex: ALL
Minimum age (years): 2
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients aged 16 years or younger who were to undergo tonsillectomy surgery were eligible for inclusion in this group. Informed consent was obtained from the parents of all the patients with a clinical diagnosis of chronic tonsillitis and tonsillar hypertrophy (except adenoidectomy surgeries) and were to undergo tonsillectomy surgery.

Brief summary: This study aimed to detect tongue edema induced by the pressure exerted by tonsillar retractor; edema detection was made through tongue area measurement using ultrasonography (USG) in pediatric patients who underwent tonsillectomy surgeries.

Detailed description: The tongue is an ideal organ for ultrasonography (USG) evaluation. This study aimed to detect the occurrence of tongue edema through USG examination and to educate clinicians about the association between subacute tongue edema and tonsillar retractor in pediatric patients.

Eligibility criteria: Inclusion Criteria for study group:

* Patients aged 16 years or younger
* Undergo tonsillectomy surgery
* Patients informed consent obtained from the parents

Exclusion Criteria for study group:

* Patients aged older than 16 years
* Patients with a history of syndromal craniofacial abnormalities
* Patients with systemic disorders and other otolaryngologic problems

Inclusion Criteria for control group:

* Patients aged 16 years or younger
* Patients who did not need tonsillectomy surgery and any head and neck procedures
* Patients who underwent endotracheal intubation under general anesthesia except tonsillectomy and head and neck surgery.

Primary outcomes:
measure: Change from preoperative measurement to postoperative measurement in tongue area on the ultrasonography imaging.
timeFrame: 2018-2019 (6 months)
Secondary outcomes:
measure: Detection of edema formation in tongue by using ultrasonography imaging.
timeFrame: 2018-2019 (6 months)
Other outcomes:
Locations:
city: Konya
country: Turkey
facility: Selcuk University
state: Selcuklu
Study officials:
References:
Clinical trial NCT02670681: Effects of Aerobic Exercise on Blood Pressure Levels of Resistant Hypertensive Subjects
Official title: Effects of Different Intensities of Aerobic Exercise on Blood Pressure Levels of Resistant Hypertensive Subjects
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hypertension
Resistant Hypertension
Keywords: Exercise
Aerobic Exercise
Lead sponsor: Federal University of Paraíba
Sponsor class: OTHER
First posted: 2016-02-02
Enrollment: 100
Sex: ALL
Minimum age (years): 40
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this intervention study is to evaluate the acute and chronic effects of different intensity (mild, moderate and high intensity) of aerobic exercise on blood pressure levels of subjects classified as resistant hypertension. Resistant hypertensives subjects aged 40 to 70, men or women with body mass index lower that 40 kg/m² are recruited and subjected in acute phase in three sessions of aerobic exercise: mild, moderate, high intensity; and session control. After, the subjects will be randomly allocated into four intervention groups: mild intensity group, moderate intensity group, high intensity group and control group. In both phases, the subjects have blood pressure data recorded by ambulatory blood pressure monitoring, for clinic and ambulatory analysis. In addition, continuously be registered biological signs of blood pressure (finometer), electrocardiogram (DII derivation) and blood flow (venous occlusion plethysmography) for analysis of cardiac autonomic modulation, vascular autonomic modulation, baroreflex sensitivity, vasodilator response and peripheral vascular resistance.


Eligibility criteria: Inclusion Criteria:

* Age between 40 and 70 years
* Men or women
* Body mass index under 40 kg / m²
* Able to participate in exercise
* No regular physically active in the last 4 months

Exclusion Criteria:

- Smoking; with history of ischemic stroke or hemorrhagic; or coronary heart disease; or obstructive pulmonary disease or chronic restrictive; or diabetes mellitus; or chronic atrial fibrillation.

Primary outcomes:
measure: Systolic, diastolic and media blood pressure
timeFrame: Pre and post-intervention (8 weeks)
Secondary outcomes:
measure: Vasodilator Response
timeFrame: Pre and post-intervention (8 weeks)
measure: Autonomic Modulation
timeFrame: Pre and post-intervention (8 weeks)
measure: Baroreflex Sensitivity
timeFrame: Pre and post-intervention (8 weeks)
Other outcomes:
Locations:
city: Joao Pessoa
country: Brazil
facility: Physical Training Study Laboratory Applied to Health; Departament of Physical Education
state: Paraíba
Study officials:
References:
citation: Nascimento LS, Santos AC, Lucena J, Silva L, Almeida A, Brasileiro-Santos MS. Acute and chronic effects of aerobic exercise on blood pressure in resistant hypertension: study protocol for a randomized controlled trial. Trials. 2017 Jun 2;18(1):250. doi: 10.1186/s13063-017-1985-5.
Clinical trial NCT06223581: Evaluation of Cardiac Burden in Patients With Sever Bronchial Asthma
Official title: Evaluation of Cardiac Burden in Patients With Sever Bronchial Asthma
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Evaluation of Cardiac Burden in Patients With Sever Bronchial Asthma
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-01-25
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Bronchial asthma is chronic bronchial inflammation of variable intensity accompanied by recurrent reversible airflow obstruction and symptoms such as coughing, wheezing, shortness of breath, and chest tightness ,with a worldwide increase over the last several decades .

1. Sever asthma :means that asthma is uncontrolled despite adherence with maximal optimized therapy and treatment contributory factors or that worsens when high dose treatment is reduced.
2. Globally. over 260 million people had poorly controlled asthma highest rate on Australia.3-3-Heart diseases are the most common cause of

Brief summary: Evaluation of cardiac burden in patients with sever bronchial asthma

Detailed description: Bronchial asthma is chronic bronchial inflammation of variable intensity accompanied by recurrent reversible airflow obstruction and symptoms such as coughing, wheezing, shortness of breath, and chest tightness ,with a worldwide increase over the last several decades (1).

1. Sever asthma :means that asthma is uncontrolled despite adherence with maximal optimized therapy and treatment contributory factors or that worsens when high dose treatment is reduced.
2. Globally. over 260 million people had poorly controlled asthma highest rate on Australia.

Eligibility criteria: Inclusion Criteria:

* Patients accepted to be involved in the study.
* Patients \>18 years old .

Exclusion Criteria:

* severe bronchial asthma patients who have other comorbidities as (chronic chest disease as COPD,ILD, bronchiectasis , , diabetic ,hypertensive ,mechanical ventilated patients, tracheostomized patients, ......)
* patients \<18 years old . patients refuse to be involved in the study .

Primary outcomes:
measure: To Evaluation of cardiac burden in patients with sever bronchial asthma
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04324281: Myth of Double Crush Syndrome in Median Nerve
Official title: Double Crush Syndrome in Median Nerve-cadaveric Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cervical Radiculopathy
Median Nerve Disease
Keywords: Wrist Pain
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-03-27
Enrollment: 12
Sex: MALE
Minimum age (years): 35
Maximum age (years): 40
Standard ages: ADULT
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: They are people who wrote consent form before death to use there cadavers in medical research.

Brief summary: There is relation between the cervical radiculopathy and carpal tunnel syndrome and why the referred pain is fall at carpal tunnel not at elbow.

Detailed description: This is an observational cadaveric study which examined median nerve from shoulder to wrist by histological measurements to explain the difference at the median nerve.

Eligibility criteria: Inclusion Criteria:

* Intact Upper Limb

Exclusion Criteria:

Amputation at upper limb

-

Primary outcomes:
measure: histological study
timeFrame: 3 month
Secondary outcomes:
Other outcomes:
Locations:
city: Maadi
country: Egypt
facility: Sahar
Study officials:
References:
Clinical trial NCT02384681: Evaluation of Auditory Fatigue in Medical Regulation Assistants
Official title: Effects of Auditory Fatigue in Medical Regulation Assistants Working With Headset: Objective Measures
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Auditory Fatigue
Keywords: Speech intelligibility
Short-term memory
Working memory
Perceived mental task load
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
Collaborators: name: University of Lorraine
name: Institut National de Recherche et de Sécurité, Nancy, France
First posted: 2015-03-10
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Medical regulation assistants working with or without headset

Brief summary: Auditory monitoring of employees is currently based on pure-tone audiometry. However, this clinical examination does not prevent from deafness but established it a posteriori. From a preventive standpoint, it is important to detect hearing professional pain before the development of irreversible(s) clinical(s) symptom(s). The investigators' hypothesis is that auditory fatigue results from damages of primary and secondary central auditory pathways involving cognitive processes.

The assessment of auditory fatigue includes the evaluation of speech intelligibility, short-term memory, working memory and perceived mental task load. The main objective of this study is to identify, among regulating medical assistants working with headset, a central auditory fatigue.


Eligibility criteria: Inclusion Criteria:

* Participants without hearing loss and without ontological antecedents in the past 5 years
* Participants gave their written informed consent
* Participants are affiliated to the french social welfare
* Preliminary clinical examination

Exclusion Criteria:

* Ontological antecedents in the past 5 years
* Pathology of the external or middle ear
* Abnormality in audiometric examination
* Participants already enrolled in an other research protocol
* Participants covered by articles L.1121-5 à L.1121-8 et L.1122-1-2 of the French Public Health Code

Primary outcomes:
measure: Change in speech intelligibility
timeFrame: Before and after the 12-hour auditory exposure
Secondary outcomes:
measure: Change in perceived mental task load
timeFrame: During (after 2-hour auditory exposure) and after the 12-hour auditory exposure
measure: Change in short-term memory
timeFrame: Before and after the 12-hour auditory exposure
measure: Change in working memory
timeFrame: Before and after the 12-hour auditory exposure
Other outcomes:
Locations:
city: Nancy
country: France
facility: University Hospital of Nancy
Study officials:
affiliation: Central Hospital, Nancy, France
name: Parietti-Winkler Cécile, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01525381: Strategies to Improve Asthma and Treatment of Asthma in Canadians
Official title: Strategies to Improve Diagnosis and Treatment of Asthma in Canadians
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Asthma
Lead sponsor: Ottawa Hospital Research Institute
Sponsor class: OTHER
First posted: 2012-02-02
Enrollment: 701
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Canadians diagnosed with Asthma and 18 years of age and older.

Brief summary: Our study will enroll 644 randomly-selected Canadians who have been diagnosed with asthma by a physician within the previous five years. It will be determined what diagnostic tests were initially performed to make this diagnosis. Participants will undergo lung function testing over 6-8 weeks to determine their respiratory status and to confirm they have asthma. Participants may be followed up to one year depending on their test results.


Eligibility criteria: Inclusion Criteria:

1. Patient must have a recent diagnosis of asthma by a physician. Diagnosis of asthma must have occurred within 5 years prior to entry into the study.
2. Patient must be at least 18 years old.

Exclusion Criteria:

1. Patients in whom methacholine challenge is contraindicated

   * Patients using chronic oral prednisone.
   * Patients with heart attack or stroke within three previous months, and those with known aortic or cerebral aneurysms.
   * Pregnant patients (unknown effect of methacholine on the fetus) and breastfeeding patients (unknown whether methacholine is excreted in breast milk).
2. Patients unable to provide informed consent.
3. Patients not able to perform spirometry and/or methacholine challenge testing.
4. Patients who have a greater than 10 pack-year smoking history (this will exclude patients with possible COPD).
5. Patients who currently have active pulmonary Tuberculosis
6. Patients who have had eye surgery in the past 3 months or who have a detached retina
7. Patients involved in another interventional asthma study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Ottawa
country: Canada
facility: Ottawa Hospital
state: Ontario
Study officials:
affiliation: Ottawa Hosptial Research Institute
name: Shawn Aaron, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00757081: Study to Evaluate the Effect of Injection Lypolysis (Lipodissolve) Treatments to Reduce Body Fat
Official title: Metabolic And Structural Effects Of Phosphatidylcholine And Deoxycholate Injections On Subcutaneous Fat
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Abdominal Subcutaneous Fat
Lead sponsor: BodyAesthetic Research Center
Sponsor class: OTHER
First posted: 2008-09-22
Enrollment: 20
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The combination of phosphatidylcholine (PPC) and deoxycholate (DC) injected into subcutaneous fat is often popularly referred to as "Lipodissolve" therapy. Despite its attractiveness as an easy and noninvasive cosmetic treatment, the safety, effectiveness, and how the injections might work remain unclear. This study will investigate the hypothesis that injections of PPC/DC will reduce the amount body fat in the treated area. If so, the mechanisms responsible for the fat loss will be explored to find out whether fat cells die from toxic effects or are broken apart by the PPC/DC. Patients will receive at least 2 (no more than 4) treatments with PPC/DC injections every 2 months. Several methods of measuring fat loss will be used in the study, including photography and measurement of patients, tissue biopsy, blood tests, and MRI. The study will also record side effects of the treatments as well as patient satisfaction.


Eligibility criteria: Inclusion Criteria:

* Healthy volunteer
* Body Mass Index (BMI) no greater than 30
* Excess fat in the lower abdomen area

Exclusion Criteria:

* Cigarette smoker
* Diabetes
* Pregnant or breast feeding
* Use anticoagulants (blood thinner), aspirin or other non-steroidal anti-inflammatory drugs that cannot be discontinued

Primary outcomes:
measure: Subcutaneous fat thickness with calipers and MRI.
timeFrame: Before and 8 weeks after final treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Creve Coeur
country: United States
facility: BodyAesthetic Research Center
state: Missouri
Study officials:
affiliation: BodyAesthetic Research Center
name: V. Leroy Young, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Reeds DN, Mohammed BS, Klein S, Boswell CB, Young VL. Metabolic and structural effects of phosphatidylcholine and deoxycholate injections on subcutaneous fat: a randomized, controlled trial. Aesthet Surg J. 2013 Mar;33(3):400-8. doi: 10.1177/1090820X13478630. Epub 2013 Feb 25.
Clinical trial NCT01946581: Retrospective Patient Satisfaction Survey in Subjects With Tecnis Intra Ocular Lenses and Cataracts Surgery
Official title: Retrospective Patient Satisfaction Survey in Subjects With Tecnis Intra Ocular Lenses Cataracts Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cataract
Lead sponsor: MDbackline, LLC
Sponsor class: OTHER
First posted: 2013-09-19
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients that have had Cataract Surgery.

Brief summary: Define what factors correlate with higher degrees of patient satisfaction and dissatisfaction among patients who have recently undergone cataract surgery.


Eligibility criteria: Inclusion Criteria:

* Patients with uncomplicated bilateral cataract surgery with a Tecnis Multifocal or monofocal implant completed at least 60 days before the survey date.
* Patient with and without astigmatic keratotomy will be included.

Exclusion Criteria:

* Patients with visually significant co-morbidities (corneal, retina, optic nerve disease) that could affect their satisfaction with surgery
* Patients with surgical complications either during or after surgery (capsule tears, iris trauma, decentered IOL, cystoid macular edema, etc.)
* Patients with ≥ grade 1 posterior capsule opacity at their last visit

Primary outcomes:
measure: Patient overall satisfaction post Cataract surgery
timeFrame: 60 plus days Post surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Laguna Hills
country: United States
facility: Harvard Eye Associates
state: California
Study officials:
affiliation: MD backline
name: John Hovanesian, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: MD Backline
name: John Hovanesian, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00983281: Use of Hextend in Trauma
Official title: Use of Hextend in Trauma
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Trauma
Keywords: Combat casualty care
Hextend
Colloid
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2009-09-24
Enrollment: 1714
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Trauma patients

Brief summary: This is a chart review of all trauma patients during the specified time period. The purpose of this study is to examine the effects of resuscitation with hextend after trauma, in the adult population. The authors hypothesize that when compared to patients resuscitated with standard of care, resuscitation with Hextend will result in a mortality difference.


Eligibility criteria: Inclusion Criteria:

* Admission to the trauma center

Exclusion Criteria:

* Pregnant women, children, psychiatric patients and prisoners.

Primary outcomes:
measure: Mortality
timeFrame: Overall inpatient mortality upon discharge from the hospital with a mean length of stay of 8 days.
Secondary outcomes:
Other outcomes:
Locations:
city: Miami
country: United States
facility: University of Miami
state: Florida
Study officials:
affiliation: University of Miami
name: Kenneth Proctor, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01232881: Predicting Response and Toxicity in Patients Receiving Lonafarnib for Breast Cancer
Official title: Predicting Response and Toxicity in Patients Receiving Lonafarnib for Breast Cancer: A Multicenter Genomic, Proteomic and Pharmacogenomic Correlative Study
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Breast Cancer
Lead sponsor: Hoosier Cancer Research Network
Sponsor class: OTHER
Collaborators: name: United States Department of Defense
name: Indiana University School of Medicine
name: Emory University
First posted: 2010-11-02
Enrollment: 27
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study population will be limited to patients with advanced breast cancer receiving treatment with lonafarnib.

Brief summary: This is a tumor and serum collection study for patients with advanced breast cancer receiving treatment with lonafarnib.

Detailed description: OUTLINE: This is a multi-center study.

Sample Collection:

* Tumor sample
* Serum sample

Treatment Regimen:

* All registered patients must be planning treatment with lonafarnib

Eligibility criteria: Inclusion Criteria:

* Written informed consent and HIPAA authorization for release of personal health information. NOTE: HIPAA authorization may be included in the informed consent or obtained separately.
* Age \> 18 years.
* Planned treatment with lonafarnib for metastatic breast cancer.
* Must consent to have a biopsy performed to obtain fresh tissue or be able to identify a formalin fixed paraffin embedded (FFPE) tissue block in which tumor samples can be obtained to complete the testing for this study.

Exclusion Criteria:

* Planned treatment with any other treatment regimen

Primary outcomes:
measure: To correlate tumor gene expression (genomic profile) with response to lonafarnib in patients with advanced breast cancer
timeFrame: 24 months
Secondary outcomes:
measure: To correlate serum and tumor proteomic profiles with response to lonafarnib
timeFrame: 24 months
measure: To compare serum and tissue proteomic analyses
timeFrame: 24 months
measure: To compare genomic and proteomic profiles
timeFrame: 24 months
measure: To correlate toxicity and /or response with drug-specific pharmacogenomic parameters
timeFrame: 24 months
Other outcomes:
Locations:
city: Indianapolis
country: United States
facility: Indiana University Melvin and Bren Simon Cancer Center
state: Indiana
Study officials:
affiliation: Hoosier Cancer Research Network
name: George Sledge, M.D.
role: STUDY_CHAIR
References: