louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02971514: Comparative Efficacy of Dental Flossing Before or After Tooth Brushing on Interproximal Plaque Reduction and Fluoride Retention in That Area
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dental Devices, Home Care
Lead sponsor: Mashhad University of Medical Sciences
Sponsor class: OTHER
First posted: 2016-11-23
Enrollment: 25
Sex: ALL
Minimum age (years): 20
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: This randomized controlled crossover trial conducted on 25 dental students. in the preliminary session each volunteer was given a toothbrush(Trisa, soft, Switzerland) and toothpaste(Pooneh, Iran) and Dental Floss( Mina, Iran)to use during the study, and they were instructed the proper techniques of brushing and flossing.The study was performed in two treatment sessions and a 48 hour washout period. They passed through the sessions in a randomized sequence. After prophylaxis with rubber cup, they were asked to discontinue all oral hygiene for 24 hour. At the first session , they flossed first followed by brushing (floss-brush group) and at the other session they used dental floss after brushing (brush-floss group) . At each session, before and after brushing and flossing , Dental plaque reduction was assessed using Rustogi Modified Navi Plaque Index. Interdental plaque was collected for measuring fluoride. Differences between the two groups were analyzed with mixed model test.


Eligibility criteria: Inclusion Criteria:

* Dental students with 16 teeth in each jaw who had Normal salivary volume No active caries No medicine which could be affect salivary secretion No fluoride consumption in the last two weeks No Antibiotic consumption in the last 4 weeks

Exclusion Criteria:

* Any systemic diseases Periodontal diseases Crowding

Primary outcomes:
measure: Dental plaque reduction
timeFrame: immediately Before brushing/ flossing and immediately after these procedures
Secondary outcomes:
measure: fluoride concentration in Interdental plaque
timeFrame: Immediately after toothbrushing /flossing interdental plaque was collected for fluoride measurement
Other outcomes:
Locations:
city: Mashhad
country: Iran, Islamic Republic of
facility: Amir Moeintaghavi
state: Khorasan Razavi
Study officials:
References:
citation: Mazhari F, Boskabady M, Moeintaghavi A, Habibi A. The effect of toothbrushing and flossing sequence on interdental plaque reduction and fluoride retention: A randomized controlled clinical trial. J Periodontol. 2018 Jul;89(7):824-832. doi: 10.1002/JPER.17-0149. Epub 2018 Jul 20.
Clinical trial NCT02929914: Effect of aPDT on Deep Caries in Permanent Tooth
Official title: Effect of Antimicrobial Photodynamic Therapy on Deep Caries in Permanent Tooth: A Pilot Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dental Caries
Keywords: Carious dentin
Photodynamic Therapy
Lead sponsor: Fujian Medical University
Sponsor class: OTHER
First posted: 2016-10-11
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to assess the clinical effect of aPDT on deep caries in permanent teeth. Half of the deep caries will receive aPDT disinfect in restorative treatment procedure, while the other half will receive sodium 0.9% saline in restorative treatment procedure.

Detailed description: The aim of the proposed study is to assess the clinical effect of antimicrobial photodynamic therapy (aPDT) using LED on dentin with deep caries in permanent teeth. Permanent teeth with deep carious lesions on the occlusal surface indicated for restorative treatment will be randomly allocated to two groups: Group 1 -Control after incomplete caries removal, washed with sodium 0.9% saline; Group 2 - PDT + CH after incomplete caries removal, disinfect the residual dentin with PDT(LED + O-Toluidine Blue). Dentin samples will be collected before and after disinfect for microbiological analysis. Then the teeth will be capped with CH and restored using resin with clinical and radiographic follow up at 6, 12 and 24 months.

Eligibility criteria: Inclusion Criteria:

* Good general health, without syndromes or chronic systemic diseases
* Permanent tooth with deep carious lesion (2/3 of dentin) without pain symptomatology and compatible with reversible pulpits

Exclusion Criteria:

* Refused to sign the informed consent document
* Allergic to photosensitizer
* Unlikely to be able to comply with the study procedures

Primary outcomes:
measure: Quantification of bacteria by colony counting
timeFrame: 2 days after dentin collection
Secondary outcomes:
measure: Tooth Pain
timeFrame: 1 day and 6, 12, 24 months
measure: Restoration Quality
timeFrame: 1 day and 6, 12, 24 months
Other outcomes:
Locations:
city: Fuzhou
country: China
facility: School and Hospital of Stomatology, Fujian Medical University
state: Fujian
Study officials:
affiliation: School and Hospital of stomatology, Fujian Medical University
name: Xiaojing Huang, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT05037214: COVID-19 : Stress Within Hospital Workers
Official title: Measure of Stress After the First Wave of Covid 19 Within Hospital Workers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID 19
Depression
Stress, Psychological
Burnout
Keywords: Psychiatry
Healthcare staff
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2021-09-08
Enrollment: 779
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthcare staff working during the first wave of COVID-19

Brief summary: As of December 2019, the global pandemic of COVID-19 has spread rapidly throughout the world, putting healthcare staff at the frontline.

In this context, several factors leading to the appearance of psychiatric symptoms have emerged : work overload, fear of being infected or of infecting, exhaustion... (The Lancet, 2020)

Indeed, post-traumatic stress disorder (PTSD), depressive symptoms, anxiety symptoms, insomnia and increased stress have been reported (Rossi et al., 2020).

Furthermore, the increased anxiety and depression symptoms and stress associated with the COVID-19 pandemic may increase the risk of suicide in this already high-risk population. For example, suicidal ideation has been reported in up to 5% of healthcare workers in the United States (Young et al., 2021).

It is therefore essential to evaluate the incidence of psychiatric disorders (e.g. PTSD, depression, suicide) and their associated risk factors among the hospital staff.

To do so, Montpellier University Hospital healthcare staff was asked their mental state during the first wave of COVID-19.


Eligibility criteria: Inclusion criteria:

* Healthcare staff working at Montpellier University Hospital during the first wave of COVID-19
* Having responded to the online survey sent to all healthcare staff

Exclusion criteria:

- Refusal to participate

Primary outcomes:
measure: Anxiety symptoms
timeFrame: day 1
measure: Depression symptoms
timeFrame: day 1
measure: Sleep
timeFrame: day 1
Secondary outcomes:
measure: Post traumatic stress disorder
timeFrame: day 1
measure: Physical pain
timeFrame: day 1
measure: Burnout symptoms
timeFrame: day 1
Other outcomes:
Locations:
city: Montpellier
country: France
facility: University hospital
Study officials:
affiliation: University Hospital, Montpellier
name: Bénédicte NOBILE, PharmD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06803914: Analysis of Biomechanical Parameters and Return to Sport After Total Hip Replacement
Official title: Analysis of Biomechanical Parameters and Return to Sport After Total Hip Replacement
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Hip Arthroplasty, Total
Lead sponsor: Clinique du Sport, Bordeaux Mérignac
Sponsor class: OTHER
First posted: 2025-01-31
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Active patients (low to high level of physical activity priori to surgery) with hip osteoarthritis necessiting total hip replacement

Brief summary: This prospective study aims to evaluate the dynamic biomechanical parameters of gait in active patients who have undergone total hip replacement (THR), focusing on movements critical for return to sport.


Eligibility criteria: Inclusion Criteria:

* Patient scheduled for total hip replacement surgery
* Active patient with low to high level of physical activity prior to surgery
* Informed consent
* Complete medical file

Exclusion Criteria:

* Contralateral hip surgery
* Neurological disorder affecting movement (e.g. Parkinson's disease, stroke)
* Spinal pathology affecting movement or posture
* Dementia or inability to complete questionnaires and assessments
* Pregnant or breast-feeding patient
* Patient under protective supervision
* Patient not covered by a social security scheme

Primary outcomes:
measure: Angular measurements by biomechanical sensors
timeFrame: 6 months after surgery
measure: Vertical forces measured by biomechanical sensors
timeFrame: 6 months after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Merignac
country: France
facility: Clinique du Sport
Study officials:
References:
Clinical trial NCT05741814: Propofol Sedation vs. Anaesthetist Guided Anaesthesia in Oocyte Pickup
Official title: Propofol Sedation vs. Anaesthetist Guided Anaesthesia in Oocyte Pickup - a Prospective Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: IVF
Keywords: Oocyte Retrieval
Sedation
Lead sponsor: Wunschbaby Institut Feichtinger
Sponsor class: OTHER
First posted: 2023-02-23
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Patients undergoing their first course of in vitro fertilisation receive either gynaecologist guided propofol only sedation or anaesthetist guided full anaesthesia. Patient satisfaction and clinical outcome will be evaluated afterwards.


Eligibility criteria: Inclusion Criteria:

Patient undergoing first oocyte pickup Understands german language to fill out questionnaire

Exclusion Criteria:

BMI \>30 BMI \<17 Heavy endometriosis Patients undergoing a consecutive IVF attempt

Primary outcomes:
measure: Patient satisfaction
timeFrame: May 2022-March 2023
Secondary outcomes:
measure: Retrieved oocytes
timeFrame: 1st of May 2022- 1st of March 2023
measure: Mature oocytes
timeFrame: 1st of May 2022-1st of March 2023
measure: Fertilised oocytes
timeFrame: 1st of May 2022- 1st of March 2023
measure: Cryopreserved blastocysts
timeFrame: 1st of May 2022- 1st of March 2023
measure: Pregnancy rate
timeFrame: 1st of May 2022- 1st of March 2023
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Wunschbaby Institut Feichtinger
Study officials:
References:
Clinical trial NCT03794414: Positive End-expiratory Pressure (PEEP) in Predicting Fluid Responsiveness in Patients Undergoing One-lung Ventilation
Official title: The Influence of Positive End-expiratory Pressure (PEEP) in Predicting Fluid Responsiveness in Patients Undergoing One-lung Ventilation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lung Cancer
Lung Diseases
Lead sponsor: Hallym University Kangnam Sacred Heart Hospital
Sponsor class: OTHER
First posted: 2019-01-07
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The present study is to evaluate the effect of positive end-expiratory pressure (PEEP) in predicting fluid responsiveness in patients undergoing one-lung ventilation.

Detailed description: Appropriate fluid challenge is crucial during lung surgery under one-lung ventilation. Applying PEEP in mechanically ventilating patients changes dynamic hemodynamic parameters (stroke volume variation, pulse pressure variation), which is more pronounced in hypovolemic patients. The aim of the present study is to evaluate the mechanically ventilating patients under one-lung ventilation requiring fluid resuscitation by applying PEEP to predict fluid responsiveness.

The investigators hypothesized that applying PEEP in one-lung ventilating patients can also change dynamic parameters and the magnitude of the change of stroke volume variation, pulse pressure variation can predict fluid responsiveness. The investigator applied PEEP 10 mmHg in one-lung ventilating patients and observed the dynamic parameters including stroke volume variation, pulse pressure variation and then infused 6ml/kg of crystalloid for fluid challenge and diagnosed fluid responsiveness as 10% increase of stroke volume after fluid challenge.

Eligibility criteria: Inclusion Criteria:

* patients undergoing lung surgery under one-lung ventilation

Exclusion Criteria:

* arrhythmia
* moderate to severe valvular heart disease moderate to severe pericardial effusion left ventricular ejection fraction \< 40%
* moderate to severe chronic obstructive lung disease
* unable to insert oesophageal Doppler Monitor (ODM) probe ( esophageal stent, esophageal cancer, previous esophageal surgery, esophageal stricture, esophageal varices, pharyngeal pouch and severe coagulopathy )
* patient refusal
* cannot understand the protocol
* less than 50kg or over 100kg in weight

Primary outcomes:
measure: pulse pressure variation
timeFrame: 5 minutes after PEEP challenge
Secondary outcomes:
measure: stroke volume variation
timeFrame: 5 minutes after PEEP challenge
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Kangnam Sungshim Hospital
Study officials:
affiliation: Kangnam Sungshim Hospital
name: Eun-mi Choi, Professor
role: STUDY_CHAIR
References:
Clinical trial NCT06477614: Anti-cancer DC Cell Vaccination to Treat Solid Tumors
Official title: Anti-cancer DC Cell Vaccination to Treat Advanced Solid Tumors: Phase I Clinical Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
Conditions: Solid Tumor, Adult
DC
Keywords: Solid Tumor
DC Vaccine
gp96
Lead sponsor: Second Affiliated Hospital of Guangzhou Medical University
Sponsor class: OTHER
First posted: 2024-06-27
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Placental or tumor-derived heat shock protein gp96 is collected, purified, and stored. The DC cells are isolated from the patient's blood and then cocultured with the gp96 to obtain the activated DC cell product. The manufactured DC cells are subcutaneously or intra-tumor injected into the patient. Clinical studies will be performed to test anti-cancer function of the DC vaccination for immunotherapy of cancer patients. In this phase I study, the safety, tolerance, and preliminary efficacy of the DC vaccine immunotherapy on advanced cancers will firstly be evaluated.

Detailed description: 1. Choose appropriate patients with advanced solid cancers, with written consent for this study;
2. Perform biopsy to get fresh sample for generation gp96 protein; Collect DC cells from the cancer patient;
3. Produce appropriate DC cell vaccine and deliver the vaccine into selected patients via local injections, and follow up closely to collect related results as required;
4. To enhance the killing capability, cotreatment the patients with vaccine aduvants or PD1/PDL1/CTLA4 antibodies may be applied;
5. Evaluate the clinical results as needed.

Eligibility criteria: Inclusion Criteria:

1. Patients with advanced cancer; 2. Life expectancy \>12 weeks; 3. Adequate heart, lung, liver, kidney, and blood function; 4. Available high quality vaccine for human use; 5. Informed consent explained to, understood by and signed by patient/guardian. Patient/guardian given copy of informed consent.

-

Exclusion Criteria:

1. Had accepted gene therapy before;
2. Severe virus infection such as HBV, HCV, HIV, et al;
3. Known HIV positivity;
4. Active infectious disease related to bacteria, virus,fungi,et al;
5. Other severe diseases that the investigators consider not appropriate;
6. Pregnant or lactating women;
7. Systemic steroid treatment (greater than or equal to 0.5 mg prednisone equivalent/kg/day);
8. Other conditions that the investigators consider not appropriate.

Primary outcomes:
measure: Number of Patients with Dose Limiting Toxicity
timeFrame: Six months
Secondary outcomes:
measure: Percent of Patients with best response as either complete remission or partial remission.
timeFrame: Six months
Other outcomes:
Locations:
city: Guanzhou
country: China
facility: The Second Affiliated Hospital of Guangzhou Medical University
state: Guangdong
Study officials:
affiliation: Second Affiliated Hospital of Guangzhou Medical University
name: Zhenfeng Zhang, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05870514: Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients
Official title: Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Critical Illness
Keywords: Deep sedation
Fospropofol
Propofol
Intensive care unit
Lead sponsor: Wuhan Union Hospital, China
Sponsor class: OTHER
First posted: 2023-05-23
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy and safety of fospropofol disodium for injection compared to propofol for deep sedation in mechanically ventilated ICU patients.

Detailed description: This is a randomized, open-label, small sample study using fospropofol disodium and propofol for deep sedation in mechanically ventilated ICU patients. Subjects are randomized to different treatment groups (including 1 for fospropofol disodium and 1 for propofol). Remifentanil is co-administered with fospropofol or propofol. Efficacy and safety profiles of fospropofol disodium and propofol are to be monitoted.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 and ≤ 80 years; Expected to require deep sedation ≥8 hours; Requirement for deep sedation (a Narcotrend index between 13 and 64).

Exclusion Criteria:

* Body mass index (BMI) \<18 or \>30 kg/m2; Contraindicate or allergic to study drugs; Moribund state; Expected to have a general anesthesia within 8 hours; Myasthenia gravis; Acute hepatitis or serious hepatic dysfunction (Child-Pugh class C); Chronic kidney disease with glomerular filtration rate (GFR) \< 29 ml/min/1.73m2; Systolic blood pressure less than 90 mm Hg after appropriate intravenous volume replacement and continuous infusions of 2 vasopressors; Acute severe neurological disorder and any other condition interfering with RASS assessment; Pregnancy or lactation; Unstable angina; Acute myocardial infarction; Left ventricular ejection fraction less than 30%; Heart rate less than 50 beats/min; Second- or third-degree heart block in the absence of a pacemaker; Alcohol abuse or drug abuse.

Primary outcomes:
measure: The percentage of time in the target sedation range without rescue sedation
timeFrame: From start of study to 48 hours
Secondary outcomes:
measure: Adverse events
timeFrame: From start of study to 48 hours
measure: 7-day ventilator free time
timeFrame: From start of study to 7 days
measure: Success rate of extubation within 7 days
timeFrame: From start of study to 7 days
measure: Length of ICU stay
timeFrame: From start of study to 28 days
measure: 28-day mortality
timeFrame: From start of study to 28 days
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Wuhan Union Hospital
state: Hubei
Study officials:
References:
Clinical trial NCT04224714: Clinical Study on the Correlation Between IMR（Index of Microcirculation Resistance） and FFR（Fractional Flow Reserve）
Official title: Clinical Study on the Correlation Between IMR（Index of Microcirculation Resistance） and FFR（Fractional Flow Reserve）
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Myocardial Ischemia
Keywords: microcirculation resistance index (IMR)
fractional flow reserve(FFR)
Lead sponsor: The People's Hospital of Liaoning Province
Sponsor class: OTHER
First posted: 2020-01-13
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: To study the effect of myocardial microcirculation disturbance on coronary flow reserve fraction, compare the evaluation value of IMR, FFR and QCA on myocardial ischemia, and discuss the correlation among them.

Detailed description: In this study, 60 patients with critical lesions indicated by coronary angiography will be admitted. The investigators collected the basic clinical data (gender, age, body mass index, smoking history, hypertension, diabetes, hyperlipidemia), laboratory data (creatinine, cholesterol, triglycerides) and measured their FFR and IMR.

Eligibility criteria: Inclusion Criteria:(1) Age: 18-75 years old, unlimited for men and women;

(2) Quantitative coronary angiography (QCA) showed that there was a critical lesion in the proximal or middle segment of the coronary artery (diameter stenosis rate was 50% - 70%), and the diameter of the artery was more than 2.5mm;

(3) Agree to participate in the study and sign informed consent

-

Exclusion Criteria:(1) Patients with acute myocardial infarction within one month;

(2) Patients with congenital heart disease, severe valve disease, dilated cardiomyopathy, pulmonary heart disease and hypertrophic cardiomyopathy;

(3) With severe heart failure (NYHA cardiac function grade ≥ grade III or left ventricular ejection fraction \< 35%);

(4) Patients with less than 1 year of stent implantation or with coronary artery bypass grafting;

(5) Patients with left main lesion, severe distorted calcification, open lesion, bifurcated lesion or complete occlusion;

(6) Patients with severe hepatorenal insufficiency;

(7) Contraindications to adenosine, aspirin and clopidogrel;

(8) Patients with advanced tumor or life expectancy less than 1 year;

(9) Patients with severe asthma or uncontrolled asthma;

(10) Women in pregnancy.

-

Primary outcomes:
measure: IMR
timeFrame: one hour
Secondary outcomes:
Other outcomes:
Locations:
city: ShenYang
country: China
facility: The people's hospital of LiaoNing Province
state: Liaoning
Study officials:
References: