louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03843476: Personalized Spine Study Group Registry
Official title: Personalized Spine Study Group Registry
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Scoliosis; Adolescence
Degenerative Disc Disease
Spinal Fusion
Kyphoscoliosis
Pseudoarthrosis of Spine
Spinal Stenosis
Kyphoses, Scheuermann
Lead sponsor: Medicrea, USA Corp.
Sponsor class: INDUSTRY
First posted: 2019-02-18
Enrollment: 0
Sex: ALL
Minimum age (years): 10
Maximum age (years): 85
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient is being implanted with patient specific rod

Brief summary: As a registry, the primary objective of the study is a data collection initiative. The study will collect clinical and radiographic outcomes of patients implanted with Medicrea's PSR. The secondary objective is to collect clinical and radiographic outcomes of patients with Medicrea hardware as a control cohort to the patient-specific rods.

Detailed description: The registry will follow the patient during their standard of care visits. At each visit, the patient will answer questions about themselves and also fill out patient reported outcome sheets. Spinopelvic measurements will be obtained on the x-rays taken. This registry is observational only, and there is no driving hypothesis for data collection. Some broad topics of discussion are:

1. Outcomes of patients sagittal profile through the pre-operative, plan and post-operative events
2. Effectiveness of rod in conjunction with other surgical implants by measurements of fusion assessment and sagittal alignment
3. Outcomes of patients in subgroups as defined by surgery performed, comorbidities, radiographic measurement, or other outcome variables
4. Rod curvature maintenance over the follow-up period
5. Understand the post-operative risks and complications from the pre-operative condition

Eligibility criteria: Inclusion Criteria:

* Patient has been/ will be operated and instrumented with PSR from Medicrea
* Patient able to complete a self- administered questionnaires
* Patient able to consent or assent

Exclusion Criteria:

* Patient unable to sign an informed consent form
* Patient unable to complete a self-administered questionnaire
* Patient is pregnant or planning on becoming pregnant during the duration of their study participation
* Patient is older than 85
* Patient is younger than 10

Primary outcomes:
measure: Data collection initiative
timeFrame: Up to 4 years
Secondary outcomes:
measure: Collect clinical and radiographic outcomes of patients with Medicrea hardware
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06644976: Monitoring Bleeding of Patients Using NOAC Anticoagulation Therapy in Proximal Femoral Fracture Internal Fixation Surgery Without Waiting. We Measure Bleeding in Surgery and the Levels of Noac Drug in Blood. We Will Try to Compare to Regular Pateints Later
Official title: Bleeding of Patients Using NOAC Anticoagulation Therapy in Proximal Femoral Fracture Internal Fixation Surgery
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Osteoperosis
Femoral Neck Fractures
Anticoagulant Therapy
Lead sponsor: Meir Hospital, Kfar Saba, Israel
Sponsor class: OTHER
First posted: 2024-10-16
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with femoral neck fracture thattake noac and arrive at meir hospital and need surgery

Brief summary: until today we waited at least 24 hours before surgery of femoral neck fractures in patients who take anticouagolation . in our new reasearch we belive that patients who take NOAC can go under surgery earlier with minimal risk


Eligibility criteria: Inclusion Criteria:

above 18 y.o femoral neck fracture NOAC capable of making inform consent primary surgery

-

Exclusion Criteria:

* under 18 y.o
* anti platelet therapy (aspirin is not included)
* creatinine clearance under 50
* active anti cancer therapy
* ITP patients
* non capable of making inform consent
* patients which decide not to proceed with the expeirment

Primary outcomes:
measure: bleeding
timeFrame: 30 days
Secondary outcomes:
Other outcomes:
Locations:
city: Kfar Saba
country: Israel
facility: Meir Hospital
Study officials:
References:
Clinical trial NCT06919276: Nicotine and Cannabis Vape Labeling Experiment - Spring 2025
Official title: Longitudinal Patterns of Non-Combustible Tobacco Product Use in Adolescents (EPIC) / Assessing Development Patterns of Vaping, Alcohol, Nicotine, and Cannabis Use and Emotional Well-being (ADVANCE)
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Vaping
Adolescent
Electronic Cigarette Use
Nicotine
Cannabis
Keywords: vaping device
product labeling
use susceptibility
perceived harm
nicotine
cannabis
Lead sponsor: University of Southern California
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
name: National Cancer Institute (NCI)
First posted: 2025-04-09
Enrollment: 3900
Sex: ALL
Minimum age (years): 11
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants will be randomized to one of seven labeling conditions and one of three device colors/flavors.
Primary purpose: OTHER

Brief summary: This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm.

Detailed description: The primary objectives of the study: (1) Determine whether different device labels with the contained substance (nicotine or cannabis) affect adolescent use susceptibility, anticipated effects or impairment, and perceived health harms; (2) Determine whether device color/product flavor differentially impact the study outcomes.

Eligibility criteria: Inclusion Criteria:

* Participants must be enrolled in a partnering high school.

Exclusion Criteria:

* Participants who cannot independently understand study consent and the study surveys are ineligible.

Primary outcomes:
measure: Use Intention Susceptibility
timeFrame: 5 minutes
measure: Perceived Health Harms
timeFrame: 5 minutes
measure: Anticipated Subjective Effects
timeFrame: 5 minutes
measure: Anticipated Impairment/Enhancement
timeFrame: 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: University of Southern California
state: California
Study officials:
References:
Clinical trial NCT06482476: Medical Students' Evaluation of Dyslipidemia and LIPoprotein(a) Study
Official title: Medical Students' Evaluation of Dyslipidemia and LIPoprotein(a) Study (MEDLIP Study)
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Insight Into the Prevalence of Elevated Lp(a) Among Greek Medical Students
Lead sponsor: University of Ioannina
Sponsor class: OTHER
First posted: 2024-07-01
Enrollment: 246
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Volunteer medical students at the Faculty of Medicine, University Hospital of Ioannina, Greece

Brief summary: This cross-sectional study aims to determine the prevalence of elevated Lp(a) levels among volunteer medical students at the Faculty of Medicine, University Hospital of Ioannina, Greece. Data collected will include demographic information, family and medical history, as well as lifestyle habits, and the study aims to provide valuable insights into the prevalence of elevated Lp(a) among Greek medical students.

Detailed description: Lipoprotein(a) \[Lp(a)\] has emerged as a prevalent monogenetic cardiovascular risk factor globally. Despite its significance, clinical attention for elevated Lp(a) is suboptimal. This cross-sectional study aims to determine the prevalence of elevated Lp(a) levels among volunteer medical students at the Faculty of Medicine, University Hospital of Ioannina, Greece, as well as gather data on the demographic characteristics and medical history of this population. Statistical analysis will assess Lp(a) levels, prevalence, and associations with demographic and cardiovascular risk factors. The study aims to provide valuable insights into the prevalence of elevated Lp(a) among Greek medical students, emphasizing the importance of awareness, early diagnosis, and management of this cardiovascular risk factor.

Eligibility criteria: Inclusion Criteria:

* Medical students at the Faculty of Medicine, University Hospital of Ioannina, Greece.

Exclusion Criteria:

* Inability/unwillingness to give informed consent

Primary outcomes:
measure: Lp(a) elevated
timeFrame: At time of measurement
measure: Lp(a) beneath cut-off
timeFrame: At time of measurement
Secondary outcomes:
Other outcomes:
Locations:
city: Ioánnina
country: Greece
facility: University Hospital of Ioannina
state: Ioannina
Study officials:
affiliation: University of Ioannina
name: Fotios Barkas, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04795076: Effect of Feeding With Nutrient Dense Formula in Malnourished Infants and Children With Congenital Heart Defects
Official title: Effect of Feeding With Nutrient Dense Formula Compared to Standard Formula on Anthropometric Indices, in Malnourished Infants and Children With Congenital Heart Defects After Repair Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Congenital Heart Disease
Lead sponsor: Shahid Beheshti University
Sponsor class: OTHER
First posted: 2021-03-12
Enrollment: 65
Sex: ALL
Minimum age (years): 6
Maximum age (years): 24
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Infants with congenital heart disease (CHD) are usually born with a normal weight but develop malnutrition over time, and about 20-50% of these children are usually malnourished. Malnutrition in these patients is multifactorial. To compensate for the increased need for infants and children with CHD, an increase in their caloric intake has been suggested. However, these patients may not be able to receive enough to meet the increased needs and catch-up growth. One of the suggested solutions in these patients to compensate for inadequate food intake is to increase the caloric density of milk or formula. For this purpose, the use of special formulas with higher calorie density or enrichment of normal formula or breast milk using special enrichment formula could be suggested. In the present study, the effect of increasing calorie intake by increasing the concentration of normal formula in comparison with formula with standard concentration on weight gain and other anthropometric indices of CHD patients with malnutrition will be compared.


Eligibility criteria: Inclusion Criteria:

* Infant and children 6 to 24 months with CHD undergoing repair surgery
* Malnutrition (weight for age Z score ≤ -1)

Exclusion Criteria:

* Allergy to cow's milk protein
* Preterm infant or infant weighing less than 2500 grams at birth
* Children with chromosomal disease (Down, Turner)

Primary outcomes:
measure: Weight
timeFrame: Change from baseline at 2 months
Secondary outcomes:
measure: Length
timeFrame: Change from baseline at 2 months
measure: Mid-arm circumference
timeFrame: Change from baseline at 2 months
measure: Head circumference
timeFrame: Change from baseline at 2 months
measure: IGF1
timeFrame: Change from baseline at 2 months
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Rajaei Cardiovascular, Medical & Research Center
Study officials:
References:
Clinical trial NCT04735276: MRI Study of the Gastric Insufflation After High-flow Nasal Oxygen (HFNO)
Official title: MRI Study of the Gastric Insufflation After High-flow Nasal Oxygen (HFNO)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: MRI
Lead sponsor: University of Liege
Sponsor class: OTHER
First posted: 2021-02-03
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: healthy adult volunteers

Brief summary: HFNO CAN BE USED AS A PREOXYGENATION TECHNIQUE BUT IS IT A SAFE TECHNIQUE IN TERMS OF GASTRIC INSUFFLATION?

Detailed description: The objective of this study is to evaluate by MRI whether the stomach is insufflated during HFNO use in healthy volunteers.

Eligibility criteria: Inclusion Criteria:

* Adults Volunteers

Exclusion Criteria:

* Pregnancy
* Claustrophobia
* Gastric surgery
* Gastric pathology

Primary outcomes:
measure: Measurement of the antero-posterior and cranio-caudal diameters of the gastric antrum
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01086176: The Impact of Post-tetanic Count on Subsequent Train-of-four During Recovery From Rocuronium
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Post-tetanic Count on One Arm, the Other Arm is the Control
Lead sponsor: Maisonneuve-Rosemont Hospital
Sponsor class: OTHER
First posted: 2010-03-12
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Poeple having general anesthesia at HMR

Brief summary: The purpose of this study is to see how long does the effect of a post-tetanic facilitation last on subsequent train-of-four. The investigators hypothesis is that the effect last at least 30 minutes.


Eligibility criteria: Inclusion Criteria:

* Patient having general anesthesia in dorsal decubitus with both arm available for at least an hour and a half

Exclusion Criteria:

* Age \>75 or \<18
* Neuromuscular disease
* difficult laryngoscopy predicted
* Allergy to rocuronium
* Malignant hyperthermia
* Full stomach
* Drugs the influence neuromuscular blockers
* Decision of the clinician to exclude his patient

Primary outcomes:
measure: The difference at 30 minutes after the post-tetanic count between the TOF% in both arms, we expect a difference of more than 10%
Secondary outcomes:
measure: The difference at 30 minutes after the post-tetanic count on the T1% (of the calibrated T1) in both arms, we expect a difference of more than 10%
measure: The difference of the slope of recuperation on TOF and T1% after a post-tetanic count vs the control arm that had no tetanic stimulation
Other outcomes:
Locations:
city: Montréal
country: Canada
facility: Hopital Maisonneuve-Rosemont
state: Quebec
Study officials:
References:
Clinical trial NCT01343576: Effect of Dairy Fat on Plasma Phytanic Acid in Human
Official title: Effect of Dairy Fat on Plasma Phytanic Acid in Healthy Volunteers - A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Heart Disease
Lead sponsor: University of Copenhagen
Sponsor class: OTHER
Collaborators: name: The Danish Dairy Research Foundation, Denmark
name: The Danish Council for Strategic Research
First posted: 2011-04-28
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of the study is to investigate if cow feeding regimes affects concentration of plasma phytanic acid and risk markers of the metabolic syndrome in human.


Eligibility criteria: Inclusion Criteria:

* sign written consent
* Age: 20-42
* BMI: 20-30
* increased risk of developing MS
* refrain from dietary supplements and blood donations prior to, and during the study

Exclusion Criteria:

* poor compliance
* if they suffering from any chronic or long lasting illness
* abuse of alcohol or medicine

Primary outcomes:
measure: plasma phytanic acid
timeFrame: before and after the intervention (4 weeks)
Secondary outcomes:
measure: total cholesterol
timeFrame: before and after the intervention (4 weeks)
measure: LDL cholesterol
timeFrame: before and after the intervention (4 weeks)
measure: HDL cholesterol
timeFrame: before and after the intervention (4 weeks)
measure: triacylglycerol
timeFrame: before and after the intervention (4 weeks)
measure: C-reactive protein
timeFrame: before and after the intervention (4 weeks)
measure: insulin
timeFrame: before and after the intervention (4 weeks)
measure: glucose
timeFrame: before and after the intervention (4 weeks)
measure: fatty acid composition in plasma
timeFrame: before and after the intervention (4 weeks)
Other outcomes:
Locations:
city: Frederiksberg
country: Denmark
facility: Department of Human Nutrition
Study officials:
affiliation: Department of Human Nutrition, University of Copenhagen
name: Tine Tholstrup, lector
role: PRINCIPAL_INVESTIGATOR
References:
citation: Werner LB, Hellgren LI, Raff M, Jensen SK, Petersen RA, Drachmann T, Tholstrup T. Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study. Lipids Health Dis. 2011 Jun 10;10:95. doi: 10.1186/1476-511X-10-95.
Clinical trial NCT06266676: Mobile Micro-course Impact on Perioperative RNs in Heart Surgery Nursing.
Official title: The Effects of Heart Surgery Nursing Mobile Micro-course in Perioperative Registered Nurse.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: periOperative
Cardiac Surgical Procedures
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2024-02-20
Enrollment: 74
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The goal of this clinical trialis to compare in learning effectiveness of nurses. The main questions it aims to answer are:

1. Can the "Micro-course" teaching enhance the awareness of cardiac surgery nursing among operating room nurses?
2. Can the "Micro-course" teaching boost the learning motivation and engagement of operating room nurses?
3. What is the satisfaction level of nurses regarding the use of "Micro-course" in cardiac surgery nursing?
4. What are the relevant factors influencing the effectiveness of the "Micro-course" teaching intervention?

Participants will be divided into two groups. The control group will receive online presentations, while the experimental group will engage in mobile learning combined with micro-courses. Both groups of participants will undergo instruction through asynchronous online courses.


Eligibility criteria: Inclusion Criteria:

1. Currently engaged in clinical surgical nursing and possess a valid nursing license.
2. Individuals who have not received training for cardiac surgery scrub nursing or who have received such training but have not worked as a cardiac surgery scrub nurse for more than two years.
3. Nurses involved in the collaborative use of personnel during operating room duty.

Exclusion Criteria:

1. Nursing supervisors at the level of charge nurse or higher.
2. Nurses exclusively engaged in local anesthesia surgical nursing.
3. Nurses primarily engaged in waiting room, recovery room, and anesthesia nursing.

Primary outcomes:
measure: Cognitive scale
timeFrame: Before the experiment commenced, all participants underwent a uniform pre-test. A post-test was administered one week after the conclusion of the course. A second post-test was conducted four weeks after the course concluded (this served as a delayed ass
measure: motivation scale
timeFrame: Before the experiment started, all participants underwent a standardized pre-test. A post-test was conducted one week after the conclusion of the course
measure: Engagement Scale
timeFrame: One week after the course concluded, measurements were taken.
Secondary outcomes:
measure: learning satisfaction
timeFrame: One week after the course concluded, measurements were taken.
Other outcomes:
Locations:
city: Taoyuan City
country: Taiwan
facility: ChangGungMH
Study officials:
References:
Clinical trial NCT02899676: Cerebral Bases of Arithmetics Processing
Official title: Neural Bases of Arithmetic Processing: MRIf Study in Adults and Children
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neural Bases of Arithmetic Processing
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2016-09-14
Enrollment: 79
Sex: ALL
Minimum age (years): 8
Maximum age (years): 24
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The aim of this study was to identify neural correlates involved in arthmetics processing in adults and children aged 8 to 14 with normal cognitive function. Brain area will be identified by functional magnetic resonance imaging (IRMf).


Eligibility criteria: Inclusion Criteria:

* children aged 8 to 14 with parents' consent
* adults aged 18 to 24
* right-handed
* affiliated to the French social security

Exclusion Criteria:

* known neurological disorders including epilepsia
* known psychiatric disorders including Attention Deficit Disorder
* birth complications needing intensive care
* central nervous system treatment
* important hearing disabilities
* not corrected impaired vision

Primary outcomes:
measure: Brain area activity in arithmetic processing will be identified by IRMf
timeFrame: up to 60 days after inclusion
Secondary outcomes:
measure: Parietal region activity in arithmetic processing will be identified by IRMf
timeFrame: up to 60 days after inclusion
Other outcomes:
Locations:
city: Bron
country: France
facility: Médecine nucléaire, Groupement Hospitalier Est, HCL
Study officials:
References: