louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06437808: Optimizing Football Training: Integrating Portable Force Plates for Advanced Performance Analysis
Official title: Optimizing Football Training at Multan Sports Complex: Integrating Portable Force Plates for Advanced Performance Analysis
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Injury;Sports
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-05-31
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Optimizing Football Training at Multan Sports Complex: Integrating Portable Force Plates for Advanced Performance Analysis," aims to enhance football training through innovative technology. Under the supervision of Dr. Junaid Gondal, this MS Rehabilitation Science project explores the use of portable force plates to provide real-time data on players' biomechanics, enabling personalized training programs that improve performance and reduce injury risks.

Detailed description: The research adopts a randomized control trial design, involving 30 male football players aged 18-35. Participants are divided into intervention and control groups, with the former using portable force plates during training. Data analysis will be conducted using IBM SPSS. This study underscores the significance of advanced performance analysis in football training, advocating for the integration of cutting-edge technology to refine training methods and enhance athletic performance at the Multan Sports Complex.

Eligibility criteria: Inclusion Criteria:

* Male football players at Multan Sports Complex
* aged 18-35
* willing to consent.

Exclusion Criteria:

* Female players
* unregistered players
* those with unstable medical conditions.

Primary outcomes:
measure: RPE Scale
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Multān
country: Pakistan
facility: Multan Sports Complex
state: Punjab
Study officials:
References:
Clinical trial NCT06548308: Comparison of Corneal Incision Versus Toric Intraocular Lens Techniques Used in Cataract Surgery
Official title: Comparison of Corneal Incision Versus Toric Intraocular Lens Techniques Used in Cataract Surgery
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Cataract Surgery
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-08-12
Enrollment: 368
Sex: ALL
Minimum age (years): 35
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Eyesight and quality of life improves in patients after refractive cataract surgery because this surgery treats myopia, hyperopia and presbyopia except astigmatism. In order to make a patient spectacle free Ophthalmologists use different methods during cataract surgery to minimize astigmatism.

Detailed description: These methods includes limbal relaxing incisions (LRIs) or the insertion of toric IOLs, which are specifically intended to cancel out pre-existing astigmatism and astigmatic keratometry. This research will be conducted to see which method benefits more for treating preoperative astigmatism in eye.

Eligibility criteria: Inclusion Criteria:

* Both genders were included.
* Patients having astigmatism was included. Patients having cataract was included.
* Eyes having no other ocular pathology was included.
* Patients having no history of corneal scar was included

Exclusion Criteria:

* Eyes having any ocular pathology will be excluded.
* Patients with corneal suture will be excluded.
* Those using contact lenses instead of spectacles for vision correction will be excluded.
* Participants with a history of eye surgery within the past year will be excluded.

Primary outcomes:
measure: postoperative visual acuity
timeFrame: 12 Months
measure: effectiveness of astigmatism correction
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Zubaida eyecare center sabzazar
Study officials:
References:
Clinical trial NCT00498108: Phase 3 Open-label Extension Trial With Rotigotine in Idiopathic Restless Legs Syndrome Subjects
Official title: An Open-label Extension Trial to Investigate the Safety and Tolerability of Long-term Treatment With Transdermal Rotigotine in Subjects With Idiopathic Restless Legs Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Idiopathic Restless Legs Syndrome
Keywords: Rotigotine
Restless Legs Syndrome
Lead sponsor: UCB Pharma
Sponsor class: INDUSTRY
First posted: 2007-07-09
Enrollment: 341
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a multicenter, open-label trial to assess safety and tolerability of rotigotine in subjects with idiopathic Restless Legs Syndrome (RLS), administered at an optimal dose for up to 1 year in subjects who previously participated in SP790 (6-month pivotal trial) or SP794 (sleep lab trial). Subjects who successfully completed the Maintenance Period and the Taper Period of SP790 or SP794 are allowed to enroll in this trial.


Eligibility criteria: Inclusion Criteria:

* Subject completed the Maintenance Period and Taper Period of SP790 or SP794

Exclusion Criteria:

* Subject has an ongoing serious adverse event (SAE) from SP790 or SP794 that is assessed to be related to the trial medication by the investigator and/or the sponsor.
* Subject has any medical or psychiatric condition that, in the opinion of the investigator, can jeopardize or would compromise the subject's ability to participate in this trial

Primary outcomes:
measure: Adverse events, changes in laboratory tests, vital signs, physical and neurological examination, menstrual and sexual function, 12-lead ECGs. Subject's rating of daytime sleepiness, global subject rating of tolerability
Secondary outcomes:
measure: Change in the International Restless Legs Scale (IRLS) sum score, in CGI Items 1 and 2-3, in RLS-6 Rating Scales. IRLS Responder
timeFrame: from Baseline at the end of the Maintenance Period
Other outcomes:
Locations:
city: Kassel
country: Germany
Study officials:
affiliation: UCB Pharma
name: UCB Clinical Trial Call Center
role: STUDY_DIRECTOR
References:
Clinical trial NCT04389008: The Study of Anesthesia-related Risk Factors for Postoperative Death in Elderly Non-cardiac Surgery Patients in China
Official title: The Study of Anesthesia-related Risk Factors for Postoperative Death in Elderly Non-cardiac Surgery Patients in China: a Multi-center Retrospective Study Based on Database
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Postoperative Mortality
Anesthesia
Elderly Patients
Noncardiac Surgery
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
First posted: 2020-05-15
Enrollment: 300000
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Since January 2008, all the elderly non-cardiac surgery patients have been treated in these four hospitals in the first medical center of PLA general hospital, henan provincial people's hospital, the second xiangya hospital of central south university, the third xiangya hospital of central south university, and the union medical college hospital affiliated to fujian medical university.

Brief summary: At present, the elderly population in China has reached 241 million, and there are more than 20 million elderly surgical patients every year, accounting for about 25% of the surgical population. However, there is no research report on the anesthesia related risk factors of death of elderly patients in hospital. The purpose of this study is to analyze the perioperative data of multicenter database, and to explore the anesthesia related death risk factors of elderly patients with noncardiac surgery in the investigator's country, especially within 24 hours after surgery, so as to help improve the anesthesia management technology of elderly patients during surgery, improve the medical quality of perioperative period, and improve the prognosis of patients.


Eligibility criteria: Inclusion Criteria:

* 1.patients larger than 65 years old at the time of surgery 2.Patients hospitalized for surgery between Jua 2008 to April 2020

Exclusion Criteria:

- 1.Critical demographic information and course records are inaccurate or missing.

2.The outcome could not be determined during the hospitalization. 3.Cardiac surgery patients 4.Patients undergoing surgery under local anesthesia

Primary outcomes:
measure: Whether death occurred during hospitalization after surgery
timeFrame: Within 30 days after discharge
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Chinese PLA General Hospital
state: Haidian
Study officials:
References:
Clinical trial NCT00032708: Dryvax Dilution-Prev Vacc Adults
Official title: A Double Blind, Randomized Dose Response Study of Dryvax Vaccine Against Smallpox in Previously Vaccinated Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Smallpox
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Sponsor class: NIH
First posted: 2002-03-29
Enrollment: 90
Standard ages: CHILD
ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: A double-blind, randomized, dose-response study of four dilutions of Dryvax in previously vaccinated adults in order to assess the clinical success rates, humoral responses, and virus-specific actifity of cytotoxi T cells and interferon-y producing T cells


Eligibility criteria: Inclusion Criteria:

* For cohort E (never vaccinated): Aged 18-31; Never been vaccinated for smallpox.
* If female, not pregnant or lactating.
* Promise to use an effective method of birth control for 7 months after vaccination.
* Negative result on a test for HIV, AIDS, Hepatitis B and C.
* Acceptable as blood donors.
* For cohorts A, B, C, D (previously vaccinated): Aged 32 to 60 years; known history of smallpox vaccination with a typical vaccinia scar; no smallpox vaccination after 1971.
* Healthy adults (aged 18-60).

Exclusion Criteria:

* Eczema or history of eczema, or other chronic skin disorder.
* Pregnancy or lactation.
* History of immunodeficiency, liver disease, severe kidney impairment, malignancy, HIV, Hepatitis B, or Hepatitis C.
* Household contact with persons who are under 12 months of age, pregnant or lactating, or have any of the specified diseases.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: St. Louis
country: United States
facility: Saint Louis University Health Sciences Center
state: Missouri
Study officials:
References:
Clinical trial NCT03142308: Surgeons' Satisfaction With the Surgical Training Program in Egypt
Official title: Young Surgeons' Satisfaction With the Surgical Training Program in Egyptian University Hospitals: A Multi-center Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Satisfaction
Keywords: Satisfaction
Training program
Egypt
Cross-sectional
Multi-center
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
Collaborators: name: Cairo University
name: Ain Shams University
name: Al-Azhar University
name: Alexandria University
First posted: 2017-05-05
Enrollment: 500
Sex: ALL
Minimum age (years): 26
Maximum age (years): 34
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Residents (juniors, sub-seniors, seniors) and assistant lectures in all surgical specialities.

Brief summary: In Egypt, the evidence for quality processes has not been established yet in the current training programs for surgery residents. There are no published articles discussing career satisfaction among surgical residents. Therefore, we are going to conduct a self-designed survey in Egyptian university hospitals to measure residents' satisfaction and display views about their undergraduate surgical education, surgical education during internship year, post-graduate training program, and extracurricular activity during medical school.


Eligibility criteria: Inclusion Criteria:

* We will include the Egyptian academic surgeons, within their first 8 years after their graduation. We will include surgeons in general surgery and other surgery subspecialties such as orthopedic surgery, neurosurgery, urology, and plastic surgery

Exclusion Criteria:

* We will exclude surgeons who received part of their training program abroad.

Primary outcomes:
measure: Surgeons' satisfaction with undergraduate surgical education, surgical training during the internship year, and residency using validated questionnaire
timeFrame: Within 8 years of graduation
Secondary outcomes:
measure: Define the reasons of dissatisfaction by validated questionnaire.
timeFrame: Within 8 years of graduation
Other outcomes:
Locations:
city: Zagazig
country: Egypt
facility: Zagazig University
Study officials:
References:
Clinical trial NCT06435208: Impact of Subgingival Instrumentation on Psychological Distress and Mental Health Status in Bruxers With Periodontitis
Official title: Impact of Subgingival Instrumentation on Psychological Distress and Mental Health Status in Bruxers With Periodontitis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Periodontal Diseases
Bruxism
Periodontitis
Distress, Emotional
Lead sponsor: Postgraduate Institute of Dental Sciences Rohtak
Sponsor class: OTHER
First posted: 2024-05-30
Enrollment: 45
Sex: ALL
Minimum age (years): 30
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Bruxism is a non-functional repetitive jaw-muscle activity characterized by grinding or clenching the teeth. Bruxism, characterized by the involuntary grinding or clenching of teeth, is a prevalent parafunctional habit affecting individuals of all ages. Stress, anxiety, and depression are the psychological factors most commonly associated with the presence of bruxism.

Detailed description: Bruxism, characterized by the involuntary grinding or clenching of teeth, is a prevalent parafunctional habit affecting individuals of all ages. Although the etiology is not known exactly, it has been suggested that bruxism is a multifactorial disorder. Periodontitis, a prevalent inflammatory condition affecting the periodontium, has been linked to bruxism in several studies. The coexistence of bruxism and periodontitis poses unique challenges in clinical management of periodontitis. Also, as periodontitis became chronic, the occurrence of depression increased. Stress, anxiety, and depression are the psychological factors most commonly associated with the presence of bruxism. Therefore, this study aims to investigate impact of subgingival instrumentation on psychological distress and mental health status in bruxers with periodontitis.

Eligibility criteria: Inclusion Criteria:

* Systemically healthy patients
* Patient having periodontitis with bruxism
* Age between 30-50 years

Exclusion Criteria:

* History of mental health disorder
* History of systemic disease
* History of drugs having the potential impact on periodontal status like phenytoin, cyclosporin, calcium-channel blockers or antidepressant drugs
* Pregnant or lactating females

Primary outcomes:
measure: Psychological distress
timeFrame: BASELINE,2 MONTHS ,3 MONTHS
measure: Mental Health Status
timeFrame: Baseline, 2 months, 3 months
Secondary outcomes:
measure: periodontal parameter
timeFrame: Baseline, 2 month, 3 month
measure: periodontal inflammation
timeFrame: Baseline, 2 month, 3 month
Other outcomes:
Locations:
city: Rohtak
country: India
facility: Post Graduate Institute of Dental Sciences
state: Haryana
Study officials:
affiliation: PGIDS , ROHTAK
name: Priyanka Chandela, BDS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00899808: Molecular Markers and Genetic Markers in Patients Undergoing Radiation Therapy for Cancer
Official title: Molecular and Genetic Markers in the Local-regional Management of Patients Undergoing Radiation Therapy
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Hematopoietic/Lymphoid Cancer
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Childhood Solid Tumor, Protocol Specific
Keywords: unspecified adult solid tumor, protocol specific
unspecified childhood solid tumor, protocol specific
hematopoietic/lymphoid cancer
Lead sponsor: Rutgers, The State University of New Jersey
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
name: Rutgers Cancer Institute of New Jersey
First posted: 2009-05-12
Enrollment: 0
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients undergoing radiation therapy for malignant disease will be eligible for these studies. Initially we will focus on specific disease sites, such as breast, prostate and lung, but ultimately we will expand this to include any disease site. Patients who met standard criteria for radiation therapy but ultimately did not receive radiation therapy will be used as a control arm if needed.

Brief summary: RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at molecular markers and genetic markers in patients undergoing radiation therapy for cancer.

Detailed description: OBJECTIVES:

Primary

* Determine local-regional control in patients undergoing radiation therapy for cancer, as a function of expression of specific molecular/genetic markers.

Secondary

* Determine complications of radiation therapy for patients undergoing radiation therapy for cancer.

OUTLINE: Previously collected tissue samples are analyzed using immunohistochemical staining and other molecular/genetic study methods to detect markers, including p53, cyclin D1, HER-2-neu, bcl-2/BAX, and EGFR. Patient charts are also reviewed with emphasis on local-regional relapse.

Eligibility criteria: DISEASE CHARACTERISTICS:

* Diagnosis of cancer
* Undergoing radiation therapy for malignant disease

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: New Brunswick
country: United States
facility: Rutgers Cancer Institute of New Jersey - Robert Wood Johnson Medical School
state: New Jersey
Study officials:
affiliation: Rutgers Cancer Institute of New Jersey- Robert Wood Johnson Medical School
name: Bruce G. Haffty, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01484808: The Utility of PSADv (PSA Density Velocity) While on Dutasteride for Predicting Prostate Cancer Incidence and Grade and Stage
Official title: Retrospective Review of Reduce Data to Determine the Utility of PSADv While on Dutasteride for Predicting Prostate Cancer Incidence and Grade and Stage
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Prostate Cancer
Keywords: PSA Density
Prostate Cancer
Prostate Biopsy
PSA
Lead sponsor: University Urological Associates Inc.
Sponsor class: OTHER
First posted: 2011-12-02
Enrollment: 6600
Sex: MALE
Minimum age (years): 50
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Men with PSA elevation (\>=4), 50-74 years old with negative biopsy of the prostate at study entry

Brief summary: This is a review of previously published data from a large prostate cancer prevention study known as REDUCE. It is the investigators intention to review whether prostate specific antigen (PSA) velocity (change over time) will predict the presence of prostate cancer and its grade and stage (severity).

Detailed description: This is a review of previously published data from a large prostate cancer prevention study known as REDUCE that utilized a 5 ARI, dutasteride. It is the investigators intention to review whether PSA velocity (change over time) will predict the presence of prostate cancer and its grade and stage (severity) by two year biopsy. The investigator will review and compare data to a previously published study of similar design with finasteride.

Eligibility criteria: Inclusion Criteria:

* Men,
* 50-74 years old with elevated PSA (\>=4) along with negative entry biopsy of the prostate who had a subsequent biopsy by 24 months.

Exclusion Criteria:

* Any positive biopsy of the prostate indicative of cancer upon entry

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Providence
country: United States
facility: Division of Urology, Brown University
state: Rhode Island
Study officials:
affiliation: University Urological Associates Inc.
name: Steven I Cohen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04324008: Clinical Comparison of Different Flowable Resin Composites
Official title: Clinical Comparison of Different Flowable Resin Composites
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Tooth Diseases
Keywords: flowable resin composite
occlusal
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2020-03-27
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to evaluate a self-adhesive flowable resin composite, a flowable resin composite with high viscosity and a conventional flowable resin composite in combination with a universal adhesive using two different application modes. All patients will receive at least 4 occlusal restorations. Cavities will be divided into four groups according to restorative systems used: Constic (a self-adhering flowable composite), G-ænial Universal Flo (a highly filled flowable composite), Tetric N-Flow (self-etch) (a conventional flowable composite), Tetrin N-Flow (etch\&rinse).


Eligibility criteria: Inclusion Criteria:

* having no medical or behavioral problems preventing then from attending review visits
* absence of previously placed restorations
* having antagonist teeth

Exclusion Criteria:

* poor gingival health
* uncontrolled, rampant caries
* bruxism
* removable partial dentures
* xerostomia

Primary outcomes:
measure: Clinical performances of different flowable resin composite
timeFrame: two years
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University
Study officials:
References: