Clinical trial NCT01068782: Study of Multiple Doses and Regimens of XL184 (Cabozantinib) in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse
Official title: A Phase 2 Non-Comparative Randomized Open-Label Study of Multiple Regimens of Single-Agent XL184 in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Astrocytic Tumors
Keywords: Glioblastoma
Glioma
Brain Cancer
Brain Tumor
Astrocytoma
Lead sponsor: Exelixis
Sponsor class: INDUSTRY
First posted: 2010-02-15
Enrollment: 19
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a study of multiple regimens of single-agent XL184 in subjects with grade IV astrocytic tumor in first or second relapse. The Randomized Phase of the study will evaluate the safety, tolerability, and preliminary efficacy of four XL184 dosing regimens in separate study arms. Subjects will be randomized to one of the study arms, which will not be blinded. After the Randomized Phase, additional subjects will be enrolled to further expand one study arm in the Expansion Phase.


Eligibility criteria: Inclusion Criteria:

* The subject has histologically confirmed diagnosis at any time of grade IV astrocytic tumor as determined by the investigator. Tumor samples will be required for pathology review.
* The subject has received prior standard radiation for any grade astrocytic tumor.
* The subject has received prior temozolomide (Temodar) therapy
* The subject has had one or two progressions as grade IV astrocytic tumor from any grade, as determined by investigator
* The subject must have a qualifying brain MRI scan within a specific timeframe prior to start of study treatment
* For subjects with recent tumor resection or biopsy, starting on study must occur a specified amount of time after the surgery and the subject must have recovered from the effects of surgery
* The subject has a Karnofsky Performance Status ≥ 70% and has the ability to swallow whole capsules
* The subject is capable of understanding the informed consent and has signed the informed consent document
* The subject has adequate organ and marrow function
* Sexually active subjects (male and female) must agree to use medically accepted methods of contraception during the course of the study and for 6 months following discontinuation of study treatment
* The subject has had no other diagnosis of malignancy (certain exceptions apply)
* Female subjects of childbearing potential must have a negative pregnancy test at screening

Exclusion Criteria:

* The subject has received certain prior anticancer therapies within a certain amount of time before starting study treatment
* The subject is receiving warfarin (or other coumarin derivatives) and is unable to switch to low molecular weight heparin
* The subject has evidence of acute intracranial or intratumoral hemorrhage either by MRI or CT scan. Subjects with resolving hemorrhage changes, punctate hemorrhage, or hemosiderin are eligible
* The subject is unable to undergo MRI scan (eg, has pacemaker)
* The subject has received enzyme-inducing anti-epileptic agents within a certain time prior to starting study treatment (eg, carbamazepine, phenytoin, phenobarbital, primidone)
* The subject has not recovered to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v3.0 Grade ≤ 1 from AEs (except alopecia and lymphopenia) due to surgery, or other medications that were administered prior to study start
* The subject has evidence of unhealed wounds
* The subject is pregnant or breast-feeding
* The subject has serious intercurrent illness or a recent history of serious disease
* The subject has inherited bleeding diathesis or coagulopathy (disease affecting how blood clots) with the risk of bleeding
* The subject has a history of any medical or surgical conditions (eg, stomach or intestinal surgery or resection) that would potentially interfere with or alter gastrointestinal function
* The subject has a history of idiopathic pulmonary fibrosis or interstitial lung disease
* The subject has received any live virus vaccine or any inactivated vaccine within a certain amount of time before starting study treatment

Primary outcomes:
measure: In the Randomized Phase, to evaluate the preliminary efficacy and tolerability of multiple regimens of XL184
timeFrame: Assessed every 1-3 weeks, during study visits
measure: In the Expansion Phase, to evaluate the efficacy of XL184 treatment
timeFrame: Assessed every 6 weeks
Secondary outcomes:
measure: To further evaluate the safety and tolerability of XL184 treatment during the entire treatment period
timeFrame: Assessed every 1-3 weeks, during study visits
measure: To further characterize the pharmacokinetic and pharmacodynamic parameters of XL184
timeFrame: Assessed every 3-4 weeks, during study visits
Other outcomes:
Locations:
city: Birmingham
country: United States
state: Alabama
city: Encinitas
country: United States
state: California
city: Pleasant Hill
country: United States
state: California
city: Chicago
country: United States
state: Illinois
city: Chicago
country: United States
state: Illinois
city: Boston
country: United States
state: Massachusetts
city: Detroit
country: United States
state: Michigan
city: Minneapolis
country: United States
state: Minnesota
city: Amhearst
country: United States
state: New York
city: Rochester
country: United States
state: New York
city: Cleveland
country: United States
state: Ohio
city: Hershey
country: United States
state: Pennsylvania
city: Dallas
country: United States
state: Texas
city: Dallas
country: United States
state: Texas
city: San Antonio
country: United States
state: Texas
city: Charlottesville
country: United States
state: Virginia
city: Seattle
country: United States
state: Washington
city: Calgary
country: Canada
state: Alberta
city: Montreal
country: Canada
state: Quebec
Study officials:
References: