Clinical trial NCT06309212: Assessing the Impact of COVID-19 on HMPV Incidence and Severity Among Adults
Official title: Assessing the Impact of COVID-19 on HMPV Incidence and Severity Among Adults
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: The Prevalance of HMPV After COVID-19 Pandemic
The Importance of Accurate Diagnosis for HPMV
Keywords: Adults
Human metapneumovirus
Post-COVID-19 era
Prevalence
Underestimated Virus
Lead sponsor: Acibadem University
Sponsor class: OTHER
First posted: 2024-03-13
Enrollment: 2197
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This retrospective study examined adults with acute respiratory tract infections in Istanbul, Turkey. Patients admitted between 2016-2020 (pre-COVID) and 2021-2023 (post-COVID) underwent multiplex PCR testing for various respiratory viruses, with a focus on human metapneumovirus. The study aimed to assess the prevalence of HMPV infection in adults and its potential change after the COVID-19 pandemic.

Brief summary: Human metapneumovirus (HMPV) is primarily recognized as a childhood pathogen, but its impact on adults remains largely underestimated. This study investigates the prevalence, clinical characteristics, and post-COVID-19 trends of HMPV infection among adults in Istanbul, Turkey.

Detailed description: Human metapneumovirus (HMPV) is primarily recognized as a childhood pathogen, but its impact on adults remains largely underestimated. This study investigates the prevalence, clinical characteristics, and post-COVID-19 trends of HMPV infection among adults in Istanbul, Turkey.

Eligibility criteria: Inclusion Criteria:

* Adults \>18 years
* Patients with acute respiratory tract infection symptoms
* Patients who underwent multiplex PCR testing for respiratory viruses

Exclusion Criteria:

* Patients for whom no respiratory viral panel test was conducted

Primary outcomes:
measure: Prevalence of HMPV infection in adults pre- and post-COVID-19 pandemic
timeFrame: Between 2016-2020 (pre-COVID) and 2021-2023 (post-COVID)
Secondary outcomes:
measure: Comparison of HMPV with other respiratory viruses in adults
timeFrame: Between 2016-2020 (pre-COVID) and 2021-2023 (post-COVID)
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Acibadem University
Study officials:
References:
citation: Niederman MS, Torres A. Respiratory infections. Eur Respir Rev. 2022 Oct 19;31(166):220150. doi: 10.1183/16000617.0150-2022. Print 2022 Dec 31.
citation: Haas LE, Thijsen SF, van Elden L, Heemstra KA. Human metapneumovirus in adults. Viruses. 2013 Jan 8;5(1):87-110. doi: 10.3390/v5010087.
citation: Boivin G, De Serres G, Hamelin ME, Cote S, Argouin M, Tremblay G, Maranda-Aubut R, Sauvageau C, Ouakki M, Boulianne N, Couture C. An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility. Clin Infect Dis. 2007 May 1;44(9):1152-8. doi: 10.1086/513204. Epub 2007 Mar 28.
citation: Chow EJ, Uyeki TM, Chu HY. The effects of the COVID-19 pandemic on community respiratory virus activity. Nat Rev Microbiol. 2023 Mar;21(3):195-210. doi: 10.1038/s41579-022-00807-9. Epub 2022 Oct 17.
citation: Pearson V. Case studies. Baton Rouge puts community first. Trustee. 1995 May;48(5):24-6. No abstract available.