Clinical trial NCT04410055: Non-exercise Physical Activity Intervention
Official title: Effects of Dynamic Standing vs. Static Standing on Subjective Fatigue Symptoms
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Diabete Mellitus
Aging
Cognitive Change
Lead sponsor: Science and Research Centre Koper
Sponsor class: OTHER
Collaborators: name: University of Michigan
First posted: 2020-06-01
Enrollment: 120
Sex: ALL
Minimum age (years): 65
Maximum age (years): 80
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Physical inactivity is prevalent in older adults and poses a risk factor for the development of type 2 diabetes. The aim of this pilot study was to examine the effect of non-exercise physical activity using a standing desk on clinical variables in older adults with type 2 diabetes.


Eligibility criteria: Inclusion Criteria:

* older participants (65+ years) with clinically confirmed type 2 diabetes
* Body mass index above 25 and less than 40 kg/m2

Exclusion Criteria:

* participants unable to perform a short clinical and motor function test battery (sABC test, Mini-BEST)

Primary outcomes:
measure: Oxygen consumption
timeFrame: change in oxygen consumption between all three conditions, which will be measured with a minimum washout period of 3 days
Secondary outcomes:
measure: Executive control
timeFrame: change in executive control and cognitive switching levels between all three conditions, which will be measured with a minimum washout period of 3 days
measure: Attention levels
timeFrame: change in attentional levels between all three conditions, which will be measured with a minimum washout period of 3 days
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
Study officials:
References:
citation: Dempsey PC, Larsen RN, Sethi P, Sacre JW, Straznicky NE, Cohen ND, Cerin E, Lambert GW, Owen N, Kingwell BA, Dunstan DW. Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities. Diabetes Care. 2016 Jun;39(6):964-72. doi: 10.2337/dc15-2336. Epub 2016 Apr 13.
citation: Wheeler MJ, Green DJ, Ellis KA, Cerin E, Heinonen I, Naylor LH, Larsen R, Wennberg P, Boraxbekk CJ, Lewis J, Eikelis N, Lautenschlager NT, Kingwell BA, Lambert G, Owen N, Dunstan DW. Distinct effects of acute exercise and breaks in sitting on working memory and executive function in older adults: a three-arm, randomised cross-over trial to evaluate the effects of exercise with and without breaks in sitting on cognition. Br J Sports Med. 2020 Jul;54(13):776-781. doi: 10.1136/bjsports-2018-100168. Epub 2019 Apr 29.
citation: Sui W, Smith ST, Fagan MJ, Rollo S, Prapavessis H. The effects of sedentary behaviour interventions on work-related productivity and performance outcomes in real and simulated office work: A systematic review. Appl Ergon. 2019 Feb;75:27-73. doi: 10.1016/j.apergo.2018.09.002. Epub 2018 Sep 18.
citation: Marusic U, Muller MLTM, Alexander NB, Bohnen NI. Feasibility and behavioral effects of prolonged static and dynamic standing as compared to sitting in older adults with type 2 diabetes mellitus. BMC Geriatr. 2020 Jun 11;20(1):204. doi: 10.1186/s12877-020-01600-0.