Clinical trial NCT00239681: JUPITER - Crestor 20mg Versus Placebo in Prevention of Cardiovascular (CV) Events
Official title: A Randomized, Double-Blind, Placebo Controlled, Multicenter, Phase 3 Study of Rosuvastatin (CRESTOR®) 20 mg in the Prevention of Cardiovascular Events Among Subjects With Low Levels of Low Density Lipoprotein(LDL) Cholesterol & Elevated Levels of C-Reactive Protein
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Elevated High-sensitivity C-Reactive Protein (hsCRP)
Keywords: Primary prevention
Cardiovascular disease
Statin therapy
C-reactive protein
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2005-10-17
Enrollment: 17802
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine the safety and effectiveness of long-term therapy with rosuvastatin compared with a placebo, and to evaluate whether treatment with rosuvastatin might be effective in reducing the risk of major cardiovascular events.

Detailed description: AstraZeneca announced it has decided to stop the CRESTOR JUPITER clinical study early based on a recommendation from an Independent Data Monitoring Board and the JUPITER Steering Committee, which met on March 29, 2008. The study will be stopped early because there is unequivocal evidence of a reduction in cardiovascular morbidity and mortality amongst patients who received CRESTOR when compared to placebo.

Eligibility criteria: Inclusion Criteria:

* Men 50 years or older, women 60 years or older
* Low to normal levels of low density lipoprotein (LDL) cholesterol (\< 130mg/dL)
* Elevated levels of C-Reactive Protein (CRP) \> 2.0 mg/L

Exclusion Criteria:

* History of cardiovascular or cerebrovascular events
* Active liver disease
* Diabetes mellitus
* Uncontrolled hypertension or hypothyroidism
* History of certain malignancies
* Chronic inflammatory conditions
* History of alcohol or drug abuse

Primary outcomes:
measure: Time to Major Cardiac Event (Cardiovascular Death, Stroke, Myocardial Infarction, Hospitalization Due to Unstable Angina or Arterial Revascularization)
timeFrame: up to 5 years
Secondary outcomes:
measure: Time to Death Due to Any Cause
timeFrame: up to 5 years
measure: Time to Non-cardiovascular Death
timeFrame: up to 5 years
measure: Time to Development of Diabetes Mellitus
timeFrame: up to 5 years
measure: Time to Venous Thromboembolic Event
timeFrame: up to 5 years
measure: Time to Bone Fracture
timeFrame: Up to 5 years
Other outcomes:
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facility: Research Site
state: Oregon
city: Lake Oswego
country: United States
facility: Research Site
state: Oregon
city: Medford
country: United States
facility: Research Site
state: Oregon
city: Milwaukie
country: United States
facility: Research Site
state: Oregon
city: Portland
country: United States
facility: Research Site
state: Oregon
city: Springfield
country: United States
facility: Research Site
state: Oregon
city: Altoona
country: United States
facility: Research Site
state: Pennsylvania
city: Beaver
country: United States
facility: Research Site
state: Pennsylvania
city: Bloomsburg
country: United States
facility: Research Site
state: Pennsylvania
city: Broomall
country: United States
facility: Research Site
state: Pennsylvania
city: Camp Hill
country: United States
facility: Research Site
state: Pennsylvania
city: Connellsville
country: United States
facility: Research Site
state: Pennsylvania
city: Downingtown
country: United States
facility: Research Site
state: Pennsylvania
city: Erie
country: United States
facility: Research Site
state: Pennsylvania
city: Feasterville
country: United States
facility: Research Site
state: Pennsylvania
city: Fleetwood
country: United States
facility: Research Site
state: Pennsylvania
city: Harleysville
country: United States
facility: Research Site
state: Pennsylvania
city: Harrisburg
country: United States
facility: Research Site
state: Pennsylvania
city: Jersey Shore
country: United States
facility: Research Site
state: Pennsylvania
city: King of Prussia
country: United States
facility: Research Site
state: Pennsylvania
city: Lansdale
country: United States
facility: Research Site
state: Pennsylvania
city: Lansdowne
country: United States
facility: Research Site
state: Pennsylvania
city: Lewisburg
country: United States
facility: Research Site
state: Pennsylvania
city: Lewistown
country: United States
facility: Research Site
state: Pennsylvania
city: Lock Haven
country: United States
facility: Research Site
state: Pennsylvania
city: McMurry
country: United States
facility: Research Site
state: Pennsylvania
city: Melrose Park
country: United States
facility: Research Site
state: Pennsylvania
city: Norristown
country: United States
facility: Research Site
state: Pennsylvania
city: Philadelphia
country: United States
facility: Research Site
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Research Site
state: Pennsylvania
city: Plymouth Meeting
country: United States
facility: Research Site
state: Pennsylvania
city: Reading
country: United States
facility: Research Site
state: Pennsylvania
city: Scotland
country: United States
facility: Research Site
state: Pennsylvania
city: Sellersville
country: United States
facility: Research Site
state: Pennsylvania
city: Souderton
country: United States
facility: Research Site
state: Pennsylvania
city: Springfield
country: United States
facility: Research Site
state: Pennsylvania
city: State College
country: United States
facility: Research Site
state: Pennsylvania
city: Stoneboro
country: United States
facility: Research Site
state: Pennsylvania
city: Tipton
country: United States
facility: Research Site
state: Pennsylvania
city: Uniontown
country: United States
facility: Research Site
state: Pennsylvania
city: Upland
country: United States
facility: Research Site
state: Pennsylvania
city: Wallingford
country: United States
facility: Research Site
state: Pennsylvania
city: Warminster
country: United States
facility: Research Site
state: Pennsylvania
city: West Grove
country: United States
facility: Research Site
state: Pennsylvania
city: West Reading
country: United States
facility: Research Site
state: Pennsylvania
city: Wilkes-barre
country: United States
facility: Research Site
state: Pennsylvania
city: York
country: United States
facility: Research Site
state: Pennsylvania
city: Cranston
country: United States
facility: Research Site
state: Rhode Island
city: Johnston
country: United States
facility: Research Site
state: Rhode Island
city: Pawtucket
country: United States
facility: Research Site
state: Rhode Island
city: Providence
country: United States
facility: Research Site
state: Rhode Island
city: Charleston
country: United States
facility: Research Site
state: South Carolina
city: Greenville
country: United States
facility: Research Site
state: South Carolina
city: Greer
country: United States
facility: Research Site
state: South Carolina
city: Hampton
country: United States
facility: Research Site
state: South Carolina
city: Moncks Corner
country: United States
facility: Research Site
state: South Carolina
city: Mt Pleasant
country: United States
facility: Research Site
state: South Carolina
city: Orangeburg
country: United States
facility: Research Site
state: South Carolina
city: Simpsonville
country: United States
facility: Research Site
state: South Carolina
city: Sioux Falls
country: United States
facility: Research Site
state: South Dakota
city: Bristol
country: United States
facility: Research Site
state: Tennessee
city: Chattanooga
country: United States
facility: Research Site
state: Tennessee
city: Clarksville
country: United States
facility: Research Site
state: Tennessee
city: Fayetteville
country: United States
facility: Research Site
state: Tennessee
city: Germantown
country: United States
facility: Research Site
state: Tennessee
city: Hendersonville
country: United States
facility: Research Site
state: Tennessee
city: Jefferson City
country: United States
facility: Research Site
state: Tennessee
city: Johnson City
country: United States
facility: Research Site
state: Tennessee
city: Memphis
country: United States
facility: Research Site
state: Tennessee
city: Morristown
country: United States
facility: Research Site
state: Tennessee
city: Nashville
country: United States
facility: Research Site
state: Tennessee
city: Arlington
country: United States
facility: Research Site
state: Texas
city: Austin
country: United States
facility: Research Site
state: Texas
city: Carrollton
country: United States
facility: Research Site
state: Texas
city: Colleyville
country: United States
facility: Research Site
state: Texas
city: Corpus Christi
country: United States
facility: Research Site
state: Texas
city: Dallas
country: United States
facility: Research Site
state: Texas
city: El Paso
country: United States
facility: Research Site
state: Texas
city: Fort Worth
country: United States
facility: Research Site
state: Texas
city: Friendswood
country: United States
facility: Research Site
state: Texas
city: Ft Worth
country: United States
facility: Research Site
state: Texas
city: Grapevine
country: United States
facility: Research Site
state: Texas
city: Houston
country: United States
facility: Research Site
state: Texas
city: Irving
country: United States
facility: Research Site
state: Texas
city: Lake Jackson
country: United States
facility: Research Site
state: Texas
city: Lubbock
country: United States
facility: Research Site
state: Texas
city: N Richland Hills
country: United States
facility: Research Site
state: Texas
city: New Braunfels
country: United States
facility: Research Site
state: Texas
city: Pharr
country: United States
facility: Research Site
state: Texas
city: Plano
country: United States
facility: Research Site
state: Texas
city: San Antonio
country: United States
facility: Research Site
state: Texas
city: Seguin
country: United States
facility: Research Site
state: Texas
city: Sugar Land
country: United States
facility: Research Site
state: Texas
city: The Woodlands
country: United States
facility: Research Site
state: Texas
city: Tyler
country: United States
facility: Research Site
state: Texas
city: Bountiful
country: United States
facility: Research Site
state: Utah
city: Nephi
country: United States
facility: Research Site
state: Utah
city: Salt Lake City
country: United States
facility: Research Site
state: Utah
city: Burlington
country: United States
facility: Research Site
state: Vermont
city: Alexandria
country: United States
facility: Research Site
state: Virginia
city: Arlington
country: United States
facility: Research Site
state: Virginia
city: Burke
country: United States
facility: Research Site
state: Virginia
city: Charlottesville
country: United States
facility: Research Site
state: Virginia
city: Hampton
country: United States
facility: Research Site
state: Virginia
city: Hayes
country: United States
facility: Research Site
state: Virginia
city: Norfolk
country: United States
facility: Research Site
state: Virginia
city: Quinton
country: United States
facility: Research Site
state: Virginia
city: Richmond
country: United States
facility: Research Site
state: Virginia
city: Springfield
country: United States
facility: Research Site
state: Virginia
city: Stuart
country: United States
facility: Research Site
state: Virginia
city: Suffolk
country: United States
facility: Research Site
state: Virginia
city: Weber City
country: United States
facility: Research Site
state: Virginia
city: Yorktown
country: United States
facility: Research Site
state: Virginia
city: Burien
country: United States
facility: Research Site
state: Washington
city: Everett
country: United States
facility: Research Site
state: Washington
city: Gig Harbor
country: United States
facility: Research Site
state: Washington
city: Olympia
country: United States
facility: Research Site
state: Washington
city: Seattle
country: United States
facility: Research Site
state: Washington
city: Spokane
country: United States
facility: Research Site
state: Washington
city: Wenatchee
country: United States
facility: Research Site
state: Washington
city: Charleston
country: United States
facility: Research Site
state: West Virginia
city: Lewisburg
country: United States
facility: Research Site
state: West Virginia
city: Beloit
country: United States
facility: Research Site
state: Wisconsin
city: Green Bay
country: United States
facility: Research Site
state: Wisconsin
city: Madison
country: United States
facility: Research Site
state: Wisconsin
city: Menomonee Falls
country: United States
facility: Research Site
state: Wisconsin
city: Milwaukee
country: United States
facility: Research Site
state: Wisconsin
city: Quilmes
country: Argentina
facility: Research Site
state: Buenos Aires - Argentina
city: Ramos Mejia
country: Argentina
facility: Research Site
state: Buenos Aires Argentina
city: San Isidro
country: Argentina
facility: Research Site
state: Buenos Aires- Argentina
city: Capital Federal
country: Argentina
facility: Research Site
state: Buenos Aires
city: Pilar
country: Argentina
facility: Research Site
state: Buenos Aires
city: Cordoba
country: Argentina
facility: Research Site
state: Cordoba - Argentina
city: Rosario
country: Argentina
facility: Research Site
state: Santa Fe- Argentina
city: San Miguel de Tucuman
country: Argentina
facility: Research Site
state: Tucuman / Argentina
city: Tucuman
country: Argentina
facility: Research Site
state: Tucuman-argentina
city: Salta
country: Argentina
facility: Research Site
city: Alsemberg
country: Belgium
facility: Research Site
city: ANS
country: Belgium
facility: Research Site
city: Anthee
country: Belgium
facility: Research Site
city: Auvelais
country: Belgium
facility: Research Site
city: Baisy-thy
country: Belgium
facility: Research Site
city: Bertrix
country: Belgium
facility: Research Site
city: Betekom
country: Belgium
facility: Research Site
city: Boechout
country: Belgium
facility: Research Site
city: Braine-l 'alleud
country: Belgium
facility: Research Site
city: Brussels
country: Belgium
facility: Research Site
city: Burdinne
country: Belgium
facility: Research Site
city: Cerexhe-heuseux
country: Belgium
facility: Research Site
city: Champion
country: Belgium
facility: Research Site
city: Chenee
country: Belgium
facility: Research Site
city: De Pinte
country: Belgium
facility: Research Site
city: Deurne (antwerpen)
country: Belgium
facility: Research Site
city: Dour
country: Belgium
facility: Research Site
city: Ekeren
country: Belgium
facility: Research Site
city: Embourg
country: Belgium
facility: Research Site
city: Evergem
country: Belgium
facility: Research Site
city: Genk
country: Belgium
facility: Research Site
city: Genly
country: Belgium
facility: Research Site
city: Gozee
country: Belgium
facility: Research Site
city: Grivegnee
country: Belgium
facility: Research Site
city: Halen
country: Belgium
facility: Research Site
city: Hasselt
country: Belgium
facility: Research Site
city: Heurne
country: Belgium
facility: Research Site
city: Heusden
country: Belgium
facility: Research Site
city: Hove
country: Belgium
facility: Research Site
city: Kessel-lo
country: Belgium
facility: Research Site
city: Komen
country: Belgium
facility: Research Site
city: Kraainem
country: Belgium
facility: Research Site
city: Landen
country: Belgium
facility: Research Site
city: Lauwe
country: Belgium
facility: Research Site
city: Leopoldsburg
country: Belgium
facility: Research Site
city: Leuven
country: Belgium
facility: Research Site
city: Libin
country: Belgium
facility: Research Site
city: Linkebeek
country: Belgium
facility: Research Site
city: Lommel
country: Belgium
facility: Research Site
city: Marchienne-au-pont
country: Belgium
facility: Research Site
city: Marchovelette
country: Belgium
facility: Research Site
city: Massemen
country: Belgium
facility: Research Site
city: Mechelen-aan-de-maas
country: Belgium
facility: Research Site
city: Melsbroek
country: Belgium
facility: Research Site
city: Moerkerke
country: Belgium
facility: Research Site
city: Mont-sur-marchienne
country: Belgium
facility: Research Site
city: Moorsel
country: Belgium
facility: Research Site
city: Mouscron
country: Belgium
facility: Research Site
city: Natoye
country: Belgium
facility: Research Site
city: Oostham
country: Belgium
facility: Research Site
city: Opgrimbie (maasmechelen)
country: Belgium
facility: Research Site
city: Oudenaarde
country: Belgium
facility: Research Site
city: Paal
country: Belgium
facility: Research Site
city: Puurs
country: Belgium
facility: Research Site
city: Ronquieres
country: Belgium
facility: Research Site
city: Ronse
country: Belgium
facility: Research Site
city: Rumst
country: Belgium
facility: Research Site
city: Saint-medard
country: Belgium
facility: Research Site
city: Schoonaarde
country: Belgium
facility: Research Site
city: Schuiferskapelle
country: Belgium
facility: Research Site
city: Sint-gillis-waas
country: Belgium
facility: Research Site
city: Steenokkerzeel
country: Belgium
facility: Research Site
city: Tavier
country: Belgium
facility: Research Site
city: Tessenderlo
country: Belgium
facility: Research Site
city: Thuin
country: Belgium
facility: Research Site
city: Tielt
country: Belgium
facility: Research Site
city: Tremelo
country: Belgium
facility: Research Site
city: Trois-ponts
country: Belgium
facility: Research Site
city: Turnhout
country: Belgium
facility: Research Site
city: Vilvoorde
country: Belgium
facility: Research Site
city: Waremme
country: Belgium
facility: Research Site
city: Weerde
country: Belgium
facility: Research Site
city: Wezembeek- Oppem
country: Belgium
facility: Research Site
city: Zoersel
country: Belgium
facility: Research Site
city: Maceio
country: Brazil
facility: Research Site
state: Alagoas
city: Salvador
country: Brazil
facility: Research Site
state: BA
city: Fortaleza
country: Brazil
facility: Research Site
state: CE
city: Goiagoianiania
country: Brazil
facility: Research Site
state: Goias
city: Belo Horizonte
country: Brazil
facility: Research Site
state: MG
city: Passo Fundo
country: Brazil
facility: Research Site
state: Rio Grande Do Sul
city: Rio de Janeiro
country: Brazil
facility: Research Site
state: RJ
city: Porto Alegre
country: Brazil
facility: Research Site
state: RS
city: Santos
country: Brazil
facility: Research Site
state: Sao Paulo
city: Sao Jose Do Rio Preto
country: Brazil
facility: Research Site
state: Sao Paulo
city: Botucatu
country: Brazil
facility: Research Site
state: SP
city: S.j.rio Preto
country: Brazil
facility: Research Site
state: SP
city: Campinas
country: Brazil
facility: Research Site
city: Sao Paulo
country: Brazil
facility: Research Site
city: Dimitrovgrad
country: Bulgaria
facility: Research Site
city: Haskovo
country: Bulgaria
facility: Research Site
city: Pleven
country: Bulgaria
facility: Research Site
city: Plovdiv
country: Bulgaria
facility: Research Site
city: Russe
country: Bulgaria
facility: Research Site
city: Sofia
country: Bulgaria
facility: Research Site
city: Varna
country: Bulgaria
facility: Research Site
city: Veliko Tarnovo
country: Bulgaria
facility: Research Site
city: Calgary
country: Canada
facility: Research Site
state: Alberta
city: Edmonton
country: Canada
facility: Research Site
state: Alberta
city: Chilliwack
country: Canada
facility: Research Site
state: British Columbia
city: Coquitlam
country: Canada
facility: Research Site
state: British Columbia
city: Kelowna
country: Canada
facility: Research Site
state: British Columbia
city: Langley
country: Canada
facility: Research Site
state: British Columbia
city: New Westminister
country: Canada
facility: Research Site
state: British Columbia
city: Penticton
country: Canada
facility: Research Site
state: British Columbia
city: Surrey
country: Canada
facility: Research Site
state: British Columbia
city: Victoria
country: Canada
facility: Research Site
state: British Columbia
city: Portage La Prairie
country: Canada
facility: Research Site
state: Manitoba
city: Winnipeg
country: Canada
facility: Research Site
state: Manitoba
city: Grand Bay - Westfield
country: Canada
facility: Research Site
state: New Brunswick
city: Moncton
country: Canada
facility: Research Site
state: New Brunswick
city: Nackawic
country: Canada
facility: Research Site
state: New Brunswick
city: Saint John
country: Canada
facility: Research Site
state: New Brunswick
city: Woodstock
country: Canada
facility: Research Site
state: New Brunswick
city: Bay Roberts
country: Canada
facility: Research Site
state: Newfoundland and Labrador
city: Carbonear
country: Canada
facility: Research Site
state: Newfoundland and Labrador
city: Conception Bay South
country: Canada
facility: Research Site
state: Newfoundland and Labrador
city: Holyrood
country: Canada
facility: Research Site
state: Newfoundland and Labrador
city: Mount Pearl
country: Canada
facility: Research Site
state: Newfoundland and Labrador
city: St. John's
country: Canada
facility: Research Site
state: Newfoundland and Labrador
city: Amherst
country: Canada
facility: Research Site
state: Nova Scotia
city: Antigonish
country: Canada
facility: Research Site
state: Nova Scotia
city: Digby
country: Canada
facility: Research Site
state: Nova Scotia
city: Halifax
country: Canada
facility: Research Site
state: Nova Scotia
city: Windsor
country: Canada
facility: Research Site
state: Nova Scotia
city: Bolton
country: Canada
facility: Research Site
state: Ontario
city: Brampton
country: Canada
facility: Research Site
state: Ontario
city: Burlington
country: Canada
facility: Research Site
state: Ontario
city: Cambridge
country: Canada
facility: Research Site
state: Ontario
city: Corunna
country: Canada
facility: Research Site
state: Ontario
city: Courtice
country: Canada
facility: Research Site
state: Ontario
city: Etobicoke
country: Canada
facility: Research Site
state: Ontario
city: Exeter
country: Canada
facility: Research Site
state: Ontario
city: Hamilton
country: Canada
facility: Research Site
state: Ontario
city: Ingersoll
country: Canada
facility: Research Site
state: Ontario
city: Kingston
country: Canada
facility: Research Site
state: Ontario
city: London
country: Canada
facility: Research Site
state: Ontario
city: Markham
country: Canada
facility: Research Site
state: Ontario
city: Newmarket
country: Canada
facility: Research Site
state: Ontario
city: Niagara Falls
country: Canada
facility: Research Site
state: Ontario
city: North Bay
country: Canada
facility: Research Site
state: Ontario
city: North York
country: Canada
facility: Research Site
state: Ontario
city: Orleans
country: Canada
facility: Research Site
state: Ontario
city: Oshawa
country: Canada
facility: Research Site
state: Ontario
city: Ottawa
country: Canada
facility: Research Site
state: Ontario
city: Perth
country: Canada
facility: Research Site
state: Ontario
city: Peterborough
country: Canada
facility: Research Site
state: Ontario
city: Renfrew
country: Canada
facility: Research Site
state: Ontario
city: Sarnia
country: Canada
facility: Research Site
state: Ontario
city: Scarborough
country: Canada
facility: Research Site
state: Ontario
city: Smith Falls
country: Canada
facility: Research Site
state: Ontario
city: St Catherines
country: Canada
facility: Research Site
state: Ontario
city: Stirling
country: Canada
facility: Research Site
state: Ontario
city: Sudbury
country: Canada
facility: Research Site
state: Ontario
city: Thornhill
country: Canada
facility: Research Site
state: Ontario
city: Thunder Bay
country: Canada
facility: Research Site
state: Ontario
city: Tillsonburg
country: Canada
facility: Research Site
state: Ontario
city: Toronto
country: Canada
facility: Research Site
state: Ontario
city: Windsor
country: Canada
facility: Research Site
state: Ontario
city: Woodstock
country: Canada
facility: Research Site
state: Ontario
city: Charlottetown
country: Canada
facility: Research Site
state: Prince Edward Island
city: Chicoutimi
country: Canada
facility: Research Site
state: Quebec
city: Courcelette
country: Canada
facility: Research Site
state: Quebec
city: Drummonville
country: Canada
facility: Research Site
state: Quebec
city: Gatineau
country: Canada
facility: Research Site
state: Quebec
city: Granby
country: Canada
facility: Research Site
state: Quebec
city: Greenfield Park
country: Canada
facility: Research Site
state: Quebec
city: Lasalle
country: Canada
facility: Research Site
state: Quebec
city: Laval
country: Canada
facility: Research Site
state: Quebec
city: Longueuil
country: Canada
facility: Research Site
state: Quebec
city: Montreal
country: Canada
facility: Research Site
state: Quebec
city: Pointe-claire
country: Canada
facility: Research Site
state: Quebec
city: Saint-georges
country: Canada
facility: Research Site
state: Quebec
city: Saint-marc-des-carrieres
country: Canada
facility: Research Site
state: Quebec
city: Sainte-catherine
country: Canada
facility: Research Site
state: Quebec
city: Sainte-julie
country: Canada
facility: Research Site
state: Quebec
city: Sherbrooke
country: Canada
facility: Research Site
state: Quebec
city: Trois-rivieres
country: Canada
facility: Research Site
state: Quebec
city: Vanier
country: Canada
facility: Research Site
state: Quebec
city: Regina
country: Canada
facility: Research Site
state: Saskatchewan
city: Saskatoon
country: Canada
facility: Research Site
state: Saskatchewan
city: Quebec
country: Canada
facility: Research Site
city: Temuco
country: Chile
facility: Research Site
state: Novena Region
city: Santiago
country: Chile
facility: Research Site
state: Region Metropolitana
city: Medellin
country: Colombia
facility: Research Site
state: Antioquia
city: Barranquilla
country: Colombia
facility: Research Site
state: Atlantico
city: Cartagena
country: Colombia
facility: Research Site
state: Bolivar
city: Pereira
country: Colombia
facility: Research Site
state: Risaralda
city: Bucaramanga
country: Colombia
facility: Research Site
state: Santander
city: Floridablanca
country: Colombia
facility: Research Site
state: Santander
city: Cali
country: Colombia
facility: Research Site
state: Valle
city: Bogota
country: Colombia
facility: Research Site
city: Desamparados
country: Costa Rica
facility: Research Site
state: San Jose
city: Escazu
country: Costa Rica
facility: Research Site
state: San Jose
city: San Pedro de Montes de Oca
country: Costa Rica
facility: Research Site
state: San Jose
city: Heredia
country: Costa Rica
facility: Research Site
city: Gentofte
country: Denmark
facility: Research Site
city: Glostrup
country: Denmark
facility: Research Site
city: Herlev
country: Denmark
facility: Research Site
city: Hillerod
country: Denmark
facility: Research Site
city: Odense C
country: Denmark
facility: Research Site
city: El Salvador
country: El Salvador
facility: Research Site
state: San Salvador
city: Salvador
country: El Salvador
facility: Research Site
city: San Salvador
country: El Salvador
facility: Research Site
city: Saku
country: Estonia
facility: Research Site
state: Harju County
city: Parnu
country: Estonia
facility: Research Site
city: Rakvere
country: Estonia
facility: Research Site
city: Tallinn
country: Estonia
facility: Research Site
city: Tartu
country: Estonia
facility: Research Site
city: Viljandi County
country: Estonia
facility: Research Site
city: Berlin
country: Germany
facility: Research Site
city: Bochum
country: Germany
facility: Research Site
city: Chemnitz
country: Germany
facility: Research Site
city: Dortmund
country: Germany
facility: Research Site
city: Dresden
country: Germany
facility: Research Site
city: Frankfurt
country: Germany
facility: Research Site
city: Gorlitz
country: Germany
facility: Research Site
city: Hamburg
country: Germany
facility: Research Site
city: Kunzing
country: Germany
facility: Research Site
city: Leipzig
country: Germany
facility: Research Site
city: Magdeburg
country: Germany
facility: Research Site
city: Nurnberg
country: Germany
facility: Research Site
city: ULM
country: Germany
facility: Research Site
city: Witten
country: Germany
facility: Research Site
city: Kiryat Hadassah
country: Israel
facility: Research Site
state: Jerusalem
city: Ashkelon Shore
country: Israel
facility: Research Site
city: Beer Yakov
country: Israel
facility: Research Site
city: Haifa
country: Israel
facility: Research Site
city: Holon
country: Israel
facility: Research Site
city: Jerusalem
country: Israel
facility: Research Site
city: Kfar-saba
country: Israel
facility: Research Site
city: Safed
country: Israel
facility: Research Site
city: Tel Aviv
country: Israel
facility: Research Site
city: Tel-hashomer
country: Israel
facility: Research Site
city: Zrifin
country: Israel
facility: Research Site
city: Mexico City
country: Mexico
facility: Research Site
state: D.F
city: Guadalajara
country: Mexico
facility: Research Site
state: Jalisco
city: Monterrey
country: Mexico
facility: Research Site
state: Nuevo Leon
city: Culiacan
country: Mexico
facility: Research Site
state: Sinaloa
city: San Luis Potosi
country: Mexico
facility: Research Site
state: SLP
city: Aguascalientes
country: Mexico
facility: Research Site
city: Alkmaar
country: Netherlands
facility: Research Site
city: Amersfoort
country: Netherlands
facility: Research Site
city: Amsterdam
country: Netherlands
facility: Research Site
city: Breda
country: Netherlands
facility: Research Site
city: Den Haag
country: Netherlands
facility: Research Site
city: Deventer
country: Netherlands
facility: Research Site
city: Eindhoven
country: Netherlands
facility: Research Site
city: Gouda
country: Netherlands
facility: Research Site
city: Groningen
country: Netherlands
facility: Research Site
city: Hoorn
country: Netherlands
facility: Research Site
city: Leiden
country: Netherlands
facility: Research Site
city: Nijmegen
country: Netherlands
facility: Research Site
city: Rotterdam
country: Netherlands
facility: Research Site
city: Tilburg
country: Netherlands
facility: Research Site
city: Utrecht
country: Netherlands
facility: Research Site
city: Velp
country: Netherlands
facility: Research Site
city: Zoetermeer
country: Netherlands
facility: Research Site
city: Bekkestua
country: Norway
facility: Research Site
city: Bergen
country: Norway
facility: Research Site
city: Boverbru
country: Norway
facility: Research Site
city: Elverum
country: Norway
facility: Research Site
city: Flatasen
country: Norway
facility: Research Site
city: Fredrikstad
country: Norway
facility: Research Site
city: Halden
country: Norway
facility: Research Site
city: Heimdal
country: Norway
facility: Research Site
city: Kristiansand
country: Norway
facility: Research Site
city: Laksevag
country: Norway
facility: Research Site
city: Lena
country: Norway
facility: Research Site
city: Lierskogen
country: Norway
facility: Research Site
city: Lovenstad
country: Norway
facility: Research Site
city: Lysaker
country: Norway
facility: Research Site
city: Moelv
country: Norway
facility: Research Site
city: Moss
country: Norway
facility: Research Site
city: Oslo
country: Norway
facility: Research Site
city: Osteras
country: Norway
facility: Research Site
city: Paradis
country: Norway
facility: Research Site
city: Radal
country: Norway
facility: Research Site
city: Randaberg
country: Norway
facility: Research Site
city: Skedsmokorset
country: Norway
facility: Research Site
city: Skiptvet
country: Norway
facility: Research Site
city: SKI
country: Norway
facility: Research Site
city: Snaroya
country: Norway
facility: Research Site
city: Sogndal
country: Norway
facility: Research Site
city: Spikkestad
country: Norway
facility: Research Site
city: Stavanger
country: Norway
facility: Research Site
city: Strommen
country: Norway
facility: Research Site
city: Svelvik
country: Norway
facility: Research Site
city: Trollasen
country: Norway
facility: Research Site
city: Trondheim
country: Norway
facility: Research Site
city: Panama
country: Panama
facility: Research Site
city: Aleksandrow Lodzki
country: Poland
facility: Research Site
city: Bydgoszcz
country: Poland
facility: Research Site
city: Bytom
country: Poland
facility: Research Site
city: Chodziez
country: Poland
facility: Research Site
city: Chorzow
country: Poland
facility: Research Site
city: Gdansk
country: Poland
facility: Research Site
city: Gliwice
country: Poland
facility: Research Site
city: Jelcz-laskowice
country: Poland
facility: Research Site
city: Karpacz
country: Poland
facility: Research Site
city: Katowice
country: Poland
facility: Research Site
city: Koluszki
country: Poland
facility: Research Site
city: Krakow
country: Poland
facility: Research Site
city: Linia
country: Poland
facility: Research Site
city: Lodz
country: Poland
facility: Research Site
city: Lublin
country: Poland
facility: Research Site
city: Nowogard
country: Poland
facility: Research Site
city: Olawa
country: Poland
facility: Research Site
city: Olsztyn
country: Poland
facility: Research Site
city: Opalenica
country: Poland
facility: Research Site
city: Opole
country: Poland
facility: Research Site
city: Ostrow Wielkopolski
country: Poland
facility: Research Site
city: Piekary Slaskie
country: Poland
facility: Research Site
city: Poznan
country: Poland
facility: Research Site
city: Pulawy
country: Poland
facility: Research Site
city: Radom
country: Poland
facility: Research Site
city: Radziejow
country: Poland
facility: Research Site
city: Rybnik
country: Poland
facility: Research Site
city: Sieradz
country: Poland
facility: Research Site
city: Skierniewice
country: Poland
facility: Research Site
city: Slupca
country: Poland
facility: Research Site
city: Sobotka
country: Poland
facility: Research Site
city: Sopot
country: Poland
facility: Research Site
city: Szczecin
country: Poland
facility: Research Site
city: Tarnow
country: Poland
facility: Research Site
city: Torun
country: Poland
facility: Research Site
city: Trzcianka
country: Poland
facility: Research Site
city: Turek
country: Poland
facility: Research Site
city: Wabrzezno
country: Poland
facility: Research Site
city: Warszawa
country: Poland
facility: Research Site
city: Wejherowo
country: Poland
facility: Research Site
city: Wroclaw
country: Poland
facility: Research Site
city: Zabrze
country: Poland
facility: Research Site
city: Aguas Buenas
country: Puerto Rico
facility: Research Site
city: Caguas
country: Puerto Rico
facility: Research Site
city: Cidra
country: Puerto Rico
facility: Research Site
city: Levittown-toa Baja
country: Puerto Rico
facility: Research Site
city: Ponce
country: Puerto Rico
facility: Research Site
city: San Juan
country: Puerto Rico
facility: Research Site
city: Cluj Napoca
country: Romania
facility: Research Site
state: Cluj
city: Timisoara
country: Romania
facility: Research Site
state: Timis
city: Brasov
country: Romania
facility: Research Site
city: Bucharest
country: Romania
facility: Research Site
city: Bucuresti
country: Romania
facility: Research Site
city: Ekaterinburg
country: Russian Federation
facility: Research Site
city: Kemerovo
country: Russian Federation
facility: Research Site
city: Krasnoyarsk
country: Russian Federation
facility: Research Site
city: Moscow
country: Russian Federation
facility: Research Site
city: Novosibirsk
country: Russian Federation
facility: Research Site
city: Saratov
country: Russian Federation
facility: Research Site
city: St-petersburg
country: Russian Federation
facility: Research Site
city: Toliatti
country: Russian Federation
facility: Research Site
city: Tomsk
country: Russian Federation
facility: Research Site
city: Tyumen
country: Russian Federation
facility: Research Site
city: Voronezh
country: Russian Federation
facility: Research Site
city: Yaroslavl
country: Russian Federation
facility: Research Site
city: Claremont
country: South Africa
facility: Research Site
state: Cape Province
city: Athlone
country: South Africa
facility: Research Site
state: Cape Town
city: Florida Park
country: South Africa
facility: Research Site
state: Gauteng
city: Lenasia
country: South Africa
facility: Research Site
state: Gauteng
city: Pretoria
country: South Africa
facility: Research Site
state: Gauteng
city: Witbank
country: South Africa
facility: Research Site
state: Gauteng
city: Durban
country: South Africa
facility: Research Site
state: Kwazulu Natal
city: Umkomaas
country: South Africa
facility: Research Site
state: Kwazulu Natal
city: Morningside Manor
country: South Africa
facility: Research Site
state: Morningside
city: Korsten
country: South Africa
facility: Research Site
state: Port Elizabeth
city: Hillcrest
country: South Africa
facility: Research Site
state: Pretoria
city: Benoni
country: South Africa
facility: Research Site
city: Halfway House
country: South Africa
facility: Research Site
city: Johannesburg
country: South Africa
facility: Research Site
city: Lakeview, Retreat
country: South Africa
facility: Research Site
city: Rustenburg
country: South Africa
facility: Research Site
city: Somerset West
country: South Africa
facility: Research Site
city: Vanderbijlpark
country: South Africa
facility: Research Site
city: Worcester
country: South Africa
facility: Research Site
city: Olten
country: Switzerland
facility: Research Site
state: Schweiz
city: Reading
country: United Kingdom
facility: Research Site
state: Berkshire
city: Annan
country: United Kingdom
facility: Research Site
state: Dumfries and Galloway
city: Blantyre
country: United Kingdom
facility: Research Site
state: Lanarkshire
city: Hamilton
country: United Kingdom
facility: Research Site
state: Lanarkshire
city: Strathaven
country: United Kingdom
facility: Research Site
state: Lanarkshire
city: Wishaw
country: United Kingdom
facility: Research Site
state: Lanarkshire
city: Paisley
country: United Kingdom
facility: Research Site
state: Renfrewshire
city: Airdrie
country: United Kingdom
facility: Research Site
state: Scotland
city: Glasgow
country: United Kingdom
facility: Research Site
state: Scotland
city: Barrhead
country: United Kingdom
facility: Research Site
city: Bellshill
country: United Kingdom
facility: Research Site
city: Birmingham
country: United Kingdom
facility: Research Site
city: Cambuslang
country: United Kingdom
facility: Research Site
city: Cardiff
country: United Kingdom
facility: Research Site
city: Chorley
country: United Kingdom
facility: Research Site
city: Cumbernauld
country: United Kingdom
facility: Research Site
city: Gourock
country: United Kingdom
facility: Research Site
city: Greenock
country: United Kingdom
facility: Research Site
city: Helensburgh
country: United Kingdom
facility: Research Site
city: Kirkintilloch
country: United Kingdom
facility: Research Site
city: Liverpool
country: United Kingdom
facility: Research Site
city: Lockerbie
country: United Kingdom
facility: Research Site
city: Manchester
country: United Kingdom
facility: Research Site
city: New Stevenson
country: United Kingdom
facility: Research Site
city: Renfrew
country: United Kingdom
facility: Research Site
city: Stranraer
country: United Kingdom
facility: Research Site
city: Strathblane
country: United Kingdom
facility: Research Site
city: Thornhill
country: United Kingdom
facility: Research Site
city: Wolverhampton
country: United Kingdom
facility: Research Site
city: Montevideo
country: Uruguay
facility: Research Site
city: Maracay, Municipio Girardot
country: Venezuela
facility: Research Site
state: Estado Aragua
city: Barinas
country: Venezuela
facility: Research Site
state: Estado Barinas
city: Ciudad Bolivar
country: Venezuela
facility: Research Site
state: Estado Bolivar
city: Puerto Ordaz
country: Venezuela
facility: Research Site
state: Estado Bolivar
city: Valencia
country: Venezuela
facility: Research Site
state: Estado Carabobo
city: Barquisimeto
country: Venezuela
facility: Research Site
state: Estado Lara
city: Merida
country: Venezuela
facility: Research Site
state: Estado Merida
city: Porlamar
country: Venezuela
facility: Research Site
state: Estado Nueva Esparta
city: Maracaibo
country: Venezuela
facility: Research Site
state: Estado Zulia
city: Latrinidad Caracas
country: Venezuela
facility: Research Site
state: Municipio Baruta
city: Caracas
country: Venezuela
facility: Research Site
city: Punto Fijo, Estado Falcon
country: Venezuela
facility: Research Site
Study officials:
affiliation: AstraZeneca
name: Judith Hsia, MD
role: STUDY_DIRECTOR
affiliation: Brigham and Women's Hospital
name: Paul Ridker, MD
role: STUDY_CHAIR
References:
citation: Ajala ON, Demler OV, Liu Y, Farukhi Z, Adelman SJ, Collins HL, Ridker PM, Rader DJ, Glynn RJ, Mora S. Anti-Inflammatory HDL Function, Incident Cardiovascular Events, and Mortality: A Secondary Analysis of the JUPITER Randomized Clinical Trial. J Am Heart Assoc. 2020 Sep;9(17):e016507. doi: 10.1161/JAHA.119.016507. Epub 2020 Aug 15.
citation: Akinkuolie AO, Lawler PR, Chu AY, Caulfield M, Mu J, Ding B, Nyberg F, Glynn RJ, Ridker PM, Hurt-Camejo E, Chasman DI, Mora S. Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1182-1190. doi: 10.1161/ATVBAHA.118.311894.
citation: Dagenais GR, Jung H, Lonn E, Bogaty PM, Dehghan M, Held C, Avezum A, Jansky P, Keltai M, Leiter LA, Lopez-Jaramillo P, Toff WD, Bosch J, Yusuf S. Effects of Lipid-Lowering and Antihypertensive Treatments in Addition to Healthy Lifestyles in Primary Prevention: An Analysis of the HOPE-3 Trial. J Am Heart Assoc. 2018 Jul 22;7(15):e008918. doi: 10.1161/JAHA.118.008918.
citation: Khera AV, Demler OV, Adelman SJ, Collins HL, Glynn RJ, Ridker PM, Rader DJ, Mora S. Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin). Circulation. 2017 Jun 20;135(25):2494-2504. doi: 10.1161/CIRCULATIONAHA.116.025678. Epub 2017 Apr 27.
citation: Akinkuolie AO, Glynn RJ, Padmanabhan L, Ridker PM, Mora S. Circulating N-Linked Glycoprotein Side-Chain Biomarker, Rosuvastatin Therapy, and Incident Cardiovascular Disease: An Analysis From the JUPITER Trial. J Am Heart Assoc. 2016 Jul 13;5(7):e003822. doi: 10.1161/JAHA.116.003822.
citation: Dugani SB, Akinkuolie AO, Paynter N, Glynn RJ, Ridker PM, Mora S. Association of Lipoproteins, Insulin Resistance, and Rosuvastatin With Incident Type 2 Diabetes Mellitus : Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2016 May 1;1(2):136-45. doi: 10.1001/jamacardio.2016.0096.
citation: Lawler PR, Akinkuolie AO, Chandler PD, Moorthy MV, Vandenburgh MJ, Schaumberg DA, Lee IM, Glynn RJ, Ridker PM, Buring JE, Mora S. Circulating N-Linked Glycoprotein Acetyls and Longitudinal Mortality Risk. Circ Res. 2016 Apr 1;118(7):1106-15. doi: 10.1161/CIRCRESAHA.115.308078. Epub 2016 Mar 7.
citation: Mora S, Caulfield MP, Wohlgemuth J, Chen Z, Superko HR, Rowland CM, Glynn RJ, Ridker PM, Krauss RM. Atherogenic Lipoprotein Subfractions Determined by Ion Mobility and First Cardiovascular Events After Random Allocation to High-Intensity Statin or Placebo: The Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial. Circulation. 2015 Dec 8;132(23):2220-9. doi: 10.1161/CIRCULATIONAHA.115.016857. Epub 2015 Sep 25.
citation: Chu AY, Giulianini F, Barratt BJ, Ding B, Nyberg F, Mora S, Ridker PM, Chasman DI. Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein-Related Measures. Circ Cardiovasc Genet. 2015 Oct;8(5):688-95. doi: 10.1161/CIRCGENETICS.114.000962. Epub 2015 Aug 13.
citation: Everett BM, Zeller T, Glynn RJ, Ridker PM, Blankenberg S. High-sensitivity cardiac troponin I and B-type natriuretic Peptide as predictors of vascular events in primary prevention: impact of statin therapy. Circulation. 2015 May 26;131(21):1851-60. doi: 10.1161/CIRCULATIONAHA.114.014522. Epub 2015 Mar 30.
citation: Everett BM, Mora S, Glynn RJ, MacFadyen J, Ridker PM. Safety profile of subjects treated to very low low-density lipoprotein cholesterol levels (<30 mg/dl) with rosuvastatin 20 mg daily (from JUPITER). Am J Cardiol. 2014 Dec 1;114(11):1682-9. doi: 10.1016/j.amjcard.2014.08.041. Epub 2014 Sep 16.
citation: Pena JM, Aspberg S, MacFadyen J, Glynn RJ, Solomon DH, Ridker PM. Statin therapy and risk of fracture: results from the JUPITER randomized clinical trial. JAMA Intern Med. 2015 Feb;175(2):171-7. doi: 10.1001/jamainternmed.2014.6388.
citation: Khera AV, Everett BM, Caulfield MP, Hantash FM, Wohlgemuth J, Ridker PM, Mora S. Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: an analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin). Circulation. 2014 Feb 11;129(6):635-42. doi: 10.1161/CIRCULATIONAHA.113.004406. Epub 2013 Nov 17.
citation: Mora S, Glynn RJ, Ridker PM. High-density lipoprotein cholesterol, size, particle number, and residual vascular risk after potent statin therapy. Circulation. 2013 Sep 10;128(11):1189-97. doi: 10.1161/CIRCULATIONAHA.113.002671. Epub 2013 Sep 3.
citation: Ridker PM, Pradhan A, MacFadyen JG, Libby P, Glynn RJ. Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial. Lancet. 2012 Aug 11;380(9841):565-71. doi: 10.1016/S0140-6736(12)61190-8.
citation: Mora S, Glynn RJ, Boekholdt SM, Nordestgaard BG, Kastelein JJ, Ridker PM. On-treatment non-high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin). J Am Coll Cardiol. 2012 Apr 24;59(17):1521-8. doi: 10.1016/j.jacc.2011.12.035.
citation: Stein EA, Vidt DG, Shepherd J, Cain VA, Anzalone D, Cressman MD. Renal safety of intensive cholesterol-lowering treatment with rosuvastatin: a retrospective analysis of renal adverse events among 40,600 participants in the rosuvastatin clinical development program. Atherosclerosis. 2012 Apr;221(2):471-7. doi: 10.1016/j.atherosclerosis.2011.12.011. Epub 2012 Jan 3.
citation: Dorresteijn JA, Visseren FL, Ridker PM, Wassink AM, Paynter NP, Steyerberg EW, van der Graaf Y, Cook NR. Estimating treatment effects for individual patients based on the results of randomised clinical trials. BMJ. 2011 Oct 3;343:d5888. doi: 10.1136/bmj.d5888.
citation: Albert MA, Glynn RJ, Fonseca FA, Lorenzatti AJ, Ferdinand KC, MacFadyen JG, Ridker PM. Race, ethnicity, and the efficacy of rosuvastatin in primary prevention: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Am Heart J. 2011 Jul;162(1):106-14.e2. doi: 10.1016/j.ahj.2011.03.032. Epub 2011 Jun 12.
citation: Ridker PM, MacFadyen JG, Glynn RJ, Chasman DI. Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention. Circ Cardiovasc Genet. 2011 Jun;4(3):312-7. doi: 10.1161/CIRCGENETICS.110.959353. Epub 2011 Apr 14.
citation: Koenig W, Ridker PM. Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk >/= 5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities. Eur Heart J. 2011 Jan;32(1):75-83. doi: 10.1093/eurheartj/ehq370. Epub 2010 Oct 22.
citation: Ridker PM, Macfadyen JG, Nordestgaard BG, Koenig W, Kastelein JJ, Genest J, Glynn RJ. Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk". Circ Cardiovasc Qual Outcomes. 2010 Sep;3(5):447-52. doi: 10.1161/CIRCOUTCOMES.110.938118. Epub 2010 Aug 24.
citation: Ridker PM, Genest J, Boekholdt SM, Libby P, Gotto AM, Nordestgaard BG, Mora S, MacFadyen JG, Glynn RJ, Kastelein JJ; JUPITER Trial Study Group. HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial. Lancet. 2010 Jul 31;376(9738):333-9. doi: 10.1016/S0140-6736(10)60713-1. Epub 2010 Jul 23.
citation: Ridker PM, MacFadyen J, Cressman M, Glynn RJ. Efficacy of rosuvastatin among men and women with moderate chronic kidney disease and elevated high-sensitivity C-reactive protein: a secondary analysis from the JUPITER (Justification for the Use of Statins in Prevention-an Intervention Trial Evaluating Rosuvastatin) trial. J Am Coll Cardiol. 2010 Mar 23;55(12):1266-1273. doi: 10.1016/j.jacc.2010.01.020. Epub 2010 Mar 4.
citation: Mora S, Glynn RJ, Hsia J, MacFadyen JG, Genest J, Ridker PM. Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and meta-analysis of women from primary prevention trials. Circulation. 2010 Mar 9;121(9):1069-77. doi: 10.1161/CIRCULATIONAHA.109.906479. Epub 2010 Feb 22.
citation: Ridker PM, MacFadyen JG, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER). Circ Cardiovasc Qual Outcomes. 2009 Nov;2(6):616-23. doi: 10.1161/CIRCOUTCOMES.109.848473. Epub 2009 Sep 22.
citation: Everett BM, Glynn RJ, MacFadyen JG, Ridker PM. Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). Circulation. 2010 Jan 5;121(1):143-50. doi: 10.1161/CIRCULATIONAHA.109.874834. Epub 2009 Dec 21.
citation: Glynn RJ, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Ridker PM. A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med. 2009 Apr 30;360(18):1851-61. doi: 10.1056/NEJMoa0900241. Epub 2009 Mar 29.
citation: Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, Macfadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Trial Study Group. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet. 2009 Apr 4;373(9670):1175-82. doi: 10.1016/S0140-6736(09)60447-5. Epub 2009 Mar 28.
citation: Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008 Nov 20;359(21):2195-207. doi: 10.1056/NEJMoa0807646. Epub 2008 Nov 9.