Clinical trial NCT06829108: Association of Transversus Abdominis Plane Block (TAPB) with Postoperative Delirium (POD) in Elderly Patients Undergoing Major Gastrointestinal Surgery
Official title: Association of Transversus Abdominis Plane Block (TAPB) with Postoperative Delirium (POD) in Elderly Patients Undergoing Major Gastrointestinal Surgery: a Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Regional Anaesthesia
Postoperative Delirium (POD)
Transversus Abdominis Plane Block (TAP Block)
Keywords: Regional Anaesthesia
Postoperative Delirium (POD)
Transversus abdominis plane block (TAP block)
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
First posted: 2025-02-17
Enrollment: 5220
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All perioperative data required for this study were obtained from patients at the First Medical Center of the Chinese PLA General Hospital from January 2016 to March 2022.

Brief summary: Postoperative delirium can increase postoperative adverse reactions and prognosis in elderly patients undergoing gastrointestinal surgery. This study studied the effects of ultrasound-guided transversal plane block on postoperative delirium, opioid consumption and prognosis in elderly patients undergoing gastrointestinal surgery, comprehensively evaluated the effectiveness and safety of TAPB, and evaluated its clinical value.

Detailed description: Postoperative delirium (POD) is a common neurocognitive disorder in elderly patients after surgery, which is characterized by attention deficit, memory impairment and confusion, usually occurring within one week after surgery. It occurs in 11%-51% of elderly patients undergoing gastrointestinal surgery and is associated with long-term poor prognosis such as dementia and increased mortality. Risk factors include advanced age, high ASA grade, hypoalbuminemia, and prolonged anesthesia. Regional nerve block (NBs), as the core means of multimodal analgesia, has been shown to reduce the incidence of POD in orthopedic and thoracic surgery by reducing opioid use and stress response, but its effect in elderly gastrointestinal surgery still needs to be further explored. Transverse abdominal muscle plane block (TAPB) is a commonly used technique in abdominal surgery. It can effectively control pain and reduce inflammation and stress response by blocking sensory nerves in the abdominal wall. This study focused on the effect of TAPB on POD in elderly patients undergoing major gastrointestinal surgery, aiming to provide evidence-based evidence for optimizing perioperative anesthesia management.

Eligibility criteria: Inclusion Criteria:

1. age ≥65 years;
2. major gastrointestinal surgery, defined as procedures lasting more than one hour and involving partial resection of the stomach or intestines;
3. general anesthesia with endotracheal intubation.

Exclusion Criteria:

1. emergency surgeries;
2. transanal endoscopic microsurgery (TEM);
3. patients with a history of preoperative delirium, altered consciousness, or psychiatric conditions, such as epilepsy, Alzheimer's disease, Parkinson's disease, schizophrenia, and anxiety or depressive disorders, as well as encephalopathies (hepatic, pulmonary, and renal) and hydrocephalus, along with those experiencing significant preoperative visual or auditory impairments;
4. patients who died within 24 h postoperatively or missing data of \>50% in their medical records.

Primary outcomes:
measure: POD incidence within 7 days postoperatively
timeFrame: within 7 days postoperatively
Secondary outcomes:
measure: intraoperative sufentanil dosage
timeFrame: intraoperative
measure: length of hospital stay
timeFrame: no more than 1 year
measure: mortality
timeFrame: 30 day after the surgery
Other outcomes:
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Study officials:
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