Clinical trial NCT04857476: Do Patients With Skin Psoriasis Have Sub-clinical Features of Active Psoriatic Arthritis on Musculoskeletal UltraSound?
Official title: Do Patients With Skin PSoriasis Have Sub-clinical Features of ACTive Psoriatic Arthritis on Musculoskeletal UltraSound?
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Psoriatic Arthritis
Lead sponsor: The Royal Wolverhampton Hospitals NHS Trust
Sponsor class: OTHER_GOV
First posted: 2021-04-23
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Psoriatic Arthritis is an inflammatory condition that typically affects joints and soft tissues such as tendons. Poorly controlled or untreated psoriatic arthritis can lead to joint damage, disability and poor physical and mental wellbeing. Evidence suggests that early diagnosis and treatment of psoriatic arthritis can minimise adverse health outcomes.

Musculoskeletal ultrasound has become an extremely useful tool in aiding rheumatologists to diagnose inflammatory joint conditions particularly at an early stage in the course of a disease.

Psoriatic arthritis is known to affect up to 30% of patients with skin psoriasis. Therefore, national dermatology guidelines advise that patients with skin psoriasis should be asked about any joint symptoms at least every year.

This study investigates whether skin psoriasis patients who are not on biologic treatment are indeed being asked about any joint symptoms and we subsequently invite patients for a musculoskeletal ultrasound scan to see if they have features of early psoriatic arthritis on ultrasound. Those who do are then invited for a thorough rheumatology clinical assessment.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of Psoriasis by a dermatologist
* Aged 18 or more
* Reasonable fluency of spoken English

Exclusion Criteria:

* Existing diagnosis of Psoriatic arthritis
* Currently on biologics for treatment of their skin Psoriasis (as this would potentially treat and thereby diminish joint symptoms associated with PsA)
* Aged \<18years old (the study focusses on an adult population)
* Currently in prison (would be unable to attend the study ultrasound scan)
* Unable to give written consent for a musculoskeletal ultrasound e.g. advanced dementia, learning difficulties (may be unable to appreciate the reason for the study and may be unable to tolerate sitting relatively still for an ultrasound scan for 60 minutes)

Primary outcomes:
measure: Proportion of patients with known skin psoriasis have features in keeping with psoriatic arthritis on musculoskeletal ultrasound
timeFrame: 3 years
measure: Risk factors associated with those psoriasis patients who do have features of psoriatic arthritis on musculoskeletal ultrasound
timeFrame: 3 years
measure: PEST Scores
timeFrame: 3 years
measure: PEST score element
timeFrame: 3 years
measure: High PEST score with normal ultrasound scan
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Wolverhampton
country: United Kingdom
facility: George Hirsch
Study officials:
affiliation: The Royal Wolverhampton NHS Trust
name: George Hirsch
role: PRINCIPAL_INVESTIGATOR
References: