Clinical trial NCT06051708: Risk Factors And Outcomes Of Hospital Acquired AKI
Official title: Risk Factors And Outcomes Of Hospital Acquired Acute Kidney Injury: A Tertiary Health Care Center Experience
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: AKI - Acute Kidney Injury
Keywords: AKI
Hospital Acquired
risk factors
outcomes
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2023-09-25
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: This research is a prospective cohort study that will include hospitalized patients in Alexandria Main University Hospital (in non-intensive care unit sittings) admitted over a period of sixteen weeks.

Patients will be divided into two groups:

Group (A) : patients who are hospitalized and develop acute kidney injury after 48 hours from admission.

Group (B) : patients who are hospitalized and do not develop acute kidney injury after 48 hours from admission till discharge.

All participants will be followed till discharge and after 3 months to assess outcomes.

Brief summary: The aim of the study is to assess the common risk factors for development of hospital acquired acute kidney injury among hospitalized patients in Alexandria Main University hospital and their outcomes.

Detailed description: Hospital-acquired AKI (HAAKI) is defined as acute renal insult occurring 48 hours or more after admission to a health care facility and It is estimated to occur in 13-18% of hospitalized patients. The early diagnosis of HAAKI reflects on improvement in morbidity and mortality rates especially in developing countries which goes parallel with the goal The International Society of Nephrology (ISN) to eliminate preventable or treatable deaths from AKI by 2025, the "0 by 25" initiative.

Data concerning the spectrum of acute kidney injury (AKI) in Egypt are generally scarce.

Eligibility criteria: Inclusion Criteria:

1. Fulfilment of definition of acute kidney injury according to KDIGO reference.
2. Age more than 18 years.

Exclusion Criteria:

1. Mentally or physically unfit patients.
2. Patients who developed acute kidney injury within 48 hours of admission to hospital.

Primary outcomes:
measure: Recovery of kidney functions
timeFrame: 12 weeks
Secondary outcomes:
measure: progression to chronic kidney disease.
timeFrame: 12 weeks
measure: mortality
timeFrame: 12 weeks
measure: Need for renal replacement therapy
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Faculty of Medicine, Aexandria University
Study officials:
affiliation: professor
name: Hala S ElWakil, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: ASS. prof
name: yasmine s naga, MD
role: STUDY_CHAIR
affiliation: Lecturer
name: Mohamed mamdouh Elsayed, MD
role: STUDY_CHAIR
affiliation: Resident
name: sara R Nagib, MBBCh
role: STUDY_CHAIR
References:
citation: Singh TB, Rathore SS, Choudhury TA, Shukla VK, Singh DK, Prakash J. Hospital-acquired acute kidney injury in medical, surgical, and intensive care unit: A comparative study. Indian J Nephrol. 2013 Jan;23(1):24-9. doi: 10.4103/0971-4065.107192.
citation: Sawhney S, Mitchell M, Marks A, Fluck N, Black C. Long-term prognosis after acute kidney injury (AKI): what is the role of baseline kidney function and recovery? A systematic review. BMJ Open. 2015 Jan 6;5(1):e006497. doi: 10.1136/bmjopen-2014-006497.
citation: Hsu CN, Lee CT, Su CH, Wang YL, Chen HL, Chuang JH, Tain YL. Incidence, Outcomes, and Risk Factors of Community-Acquired and Hospital-Acquired Acute Kidney Injury: A Retrospective Cohort Study. Medicine (Baltimore). 2016 May;95(19):e3674. doi: 10.1097/MD.0000000000003674.
citation: Ponce D, Balbi A. Acute kidney injury: risk factors and management challenges in developing countries. Int J Nephrol Renovasc Dis. 2016 Aug 22;9:193-200. doi: 10.2147/IJNRD.S104209. eCollection 2016.