louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06962982: This Study Explores How Short-term Immersive VR With Exercises and Ergonomic Training Can Reduce Neck Pain, Improve Movement, Strength, and Work Productivity in Computer Users Who Are at High Risk Due to Prolonged Screen Time and Poor Posture.
Official title: Effect of Short Term Immersive VR Intervention With Exercises and Ergonomic Training on Neck Pain, Cervical ROM, Neck Endurance, Neck Disability and Work Productivity Among Computer Users.
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Neck Pain
Neck Disability
Neck Endurance
Work Productivity
Cervical Range of Motion
Keywords: ergonomic training
neck pain
cervical ROM
neck endurance
neck disability
work productivity
computer users
Lead sponsor: Gulf Medical University
Sponsor class: OTHER
First posted: 2025-05-08
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: participants will be randomly divided into two groups
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to learn if a short-term immersive Virtual Reality (VR) intervention, combined with exercises and ergonomic training, can help treat neck pain in computer users. It will also explore how safe and effective this approach is. The main questions it aims to answer are:

Does immersive VR with exercise and ergonomic training reduce neck pain and disability?

Does it improve cervical range of motion, neck muscle endurance, and work productivity?

Researchers will compare the effects before and after the intervention to see how well it works for managing neck pain in computer users.

Participants will:

Use immersive VR exercises and receive ergonomic training over a short period

Attend assessment sessions to measure pain, movement, endurance, and work productivity

Follow specific guidelines for posture and workplace adjustments during the study


Eligibility criteria: Inclusion Criteria:

1. Computer users of age 18 to 50 years old with history of more than 6 hours of screen time. (9)
2. Complaints of neck pain.

Exclusion Criteria:

1. Individuals having complains of vertigo
2. Radiating pain
3. Balance issues
4. Motion sickness
5. Recent cervical fractures/dislocations or whiplash injuries
6. Complaints of photosensitivity
7. Complaints of frequent headaches

Primary outcomes:
measure: The Numeric Pain Rating Scale
timeFrame: 3 weeks
measure: Cervical Range of Motion
timeFrame: 3 weeks
Secondary outcomes:
measure: The Neck Disability Index
timeFrame: 3 weeks
measure: Computer Workstation Ergonomics Self-Assessment Checklist
timeFrame: 3 weeks
measure: Work Productivity and Activity Impairment Questionnaire
timeFrame: 3 weeks
measure: System usability scale (SUS) (applicable for group B)
timeFrame: 3 weeks
Other outcomes:
Locations:
city: Ajman
country: United Arab Emirates
facility: Thumbay Medicity, Al Jurf, Ajman
Study officials:
References:
Clinical trial NCT05266482: Personalized Information Before and After Total Knee Arthroplasty: PAK-study
Official title: Personal Feedback on Patient-reported Outcomes to Fulfil or Exceed Preoperative Expectations of Primary Total Knee Arthroplasty Patients: PAK-study.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Total Knee Arthroplasty
Keywords: Satisfaction
Expectations
Personal feedback
Lead sponsor: Kliniek ViaSana
Sponsor class: OTHER
First posted: 2022-03-04
Enrollment: 452
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Despite positive results following total knee arthroplasty (TKA), some patients are dissatisfied after recovery. Unfulfilled expectations is a key predictor of dissatisfaction. The aim of this study is to investigate if more patients fulfil or exceed their preoperative expectations one year after TKA when personal feedback on their PROs is given.


Eligibility criteria: Inclusion Criteria:

* Planned for primary TKA in Kliniek ViaSana
* Signed informed consent

Exclusion Criteria:

* Aged under 18 years
* Do not possess an own email adress,
* Do not have a thorough command of the Dutch language,
* Previously received contra-lateral primary TKA and/or unicompartmental KA.

Primary outcomes:
measure: Patients' expectations
timeFrame: 12 months after surgery
Secondary outcomes:
measure: Patients' expectations
timeFrame: 3 and 6 months after surgery
measure: Patients' satisfaction
timeFrame: 3, 6 and 12 months after surgery
measure: Pain relief
timeFrame: 3, 6 and 12 months after surgery
measure: Functional improvement
timeFrame: 3, 6 and 12 months after surgery
measure: Perceived recovery
timeFrame: 3, 6 and 12 months after surgery
Other outcomes:
Locations:
city: Mill
country: Netherlands
facility: Kliniek ViaSana
Study officials:
affiliation: Kliniek ViaSana
name: J.M. Brinkman, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05838482: Clinical Feasibility and Evaluation of Silicon Photon Counting CT
Official title: Clinical Feasibility and Evaluation of Silicon Photon Counting CT
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: CT Photon-Counting
Lead sponsor: GE Healthcare
Sponsor class: INDUSTRY
Collaborators: name: Stanford University
First posted: 2023-05-01
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The subject population will consist of adults that are 18-years of age or older, and who have undergone a prior clinically-indicated CT exam of at least one of the following anatomical area(s): head, neck, heart, chest, abdomen, pelvis, and/or extremities.

Brief summary: The purpose of the study is to collect data to evaluate utility of the using photon-counting CT in a clinical setting.

Detailed description: Data collected in this study includes an assessment of image quality parameters including spatial resolution, image contrast, and noise that will evaluate the product and how this photon-counting CT technology can be used to reduce the overall radiation dose in CT imaging, and enhance clinical applications for CT technology. This data and analysis will help support regulatory submission.

Eligibility criteria: Inclusion Criteria:

* Who are 18 years of age or older
* Able to sign and date the informed consent form
* Who have in the past 120 days or will in the future 30 days undergo a clinically-indicated CT exam of the head, neck, heart, chest, abdomen, pelvis, or extremities where images are available for this prior scheduled exam

Exclusion Criteria:

* Who are pregnant or lactating;
* Who were previously enrolled in this study;
* For contrast-enhanced CT exams, anyone with known or suspected allergy to iodinated contrast agents
* For contrast-enhanced CT exams, anyone with known or suspected renal insufficiency as determined by site medical personnel;
* Who need urgent or emergent care;
* Who have any conditions that, in the opinion of the PI or designee, would interfere with the evaluation of the results or constitute a health hazard for the subject; OR
* Who are unwilling to have GEHC personnel present for the CT exam.

Primary outcomes:
measure: Data Collection
timeFrame: 1 year
Secondary outcomes:
measure: Image Quality
timeFrame: 1 year
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Stanford University
state: California
Study officials:
affiliation: GE Healthcare
name: Brian Thomsen
role: STUDY_DIRECTOR
References:
Clinical trial NCT00069082: Intranasal Civamide for Episodic Cluster Headache
Official title: A Phase III, Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multicenter Evaluation of Civamide (Zucapsaicin) Nasal Solution in the Treatment of Episodic Cluster Headache
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Episodic Cluster Headache
Keywords: Headache
Cluster
EC
Episodic Cluster
Lead sponsor: Winston Laboratories
Sponsor class: INDUSTRY
First posted: 2003-09-16
Enrollment: 2
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a 49-day study to evaluate the effectiveness of Intranasal Civamide (Zucapsaicin) in the treatment of an episodic cluster headache period compared to placebo (medically inactive substance which does not contain any active ingredients).


Eligibility criteria: * At least 2 year history of episodic cluster headache (meeting IHS criteria)
* At least 2 previous episodes
* Expected duration of cluster period is at least 6 weeks but not longer than 24 weeks
* At least 1 but not more than 8 headaches on each of the 3 days immediately prior to treatment

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: San Francisco Clinical Research Center
state: California
city: Santa Monica
country: United States
facility: California Medical Clinic for Headache
state: California
city: Denver
country: United States
facility: Colorado Neurology and Headache Clinic
state: Colorado
city: Chicago
country: United States
facility: Diamond Headache Clinic
state: Illinois
city: New York
country: United States
facility: New York Headache Center
state: New York
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
Study officials:
affiliation: Winston Laboratories
name: Scott B Phillips, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03169582: Avanafil Versus Sildenafil in Spinal Cord Injury Erectile Dysfunction
Official title: Avanafil Versus Sildenafil in Spinal Cord Injury Erectile Dysfunction: Non- Inferiority, Randomized, Crossover, Open Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Erectile Dysfunction
Lead sponsor: Hospital Nacional de Parapléjicos de Toledo
Sponsor class: OTHER
First posted: 2017-05-30
Enrollment: 78
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: non- inferiority, randomized, crossover, open clinical trial
Primary purpose: TREATMENT

Brief summary: The main goal of this study is to compare the use of Avanafil versus Sildenafil in spinal cord injury erectile dysfunction. The study has the characteristics of a non- inferiority, randomized, crossover, open clinical trial. The principal variable is the IIEF-EF (Erectile Function Domain questionnaire of the International Index of Erectile Function IIEF).

This is an interventional study


Eligibility criteria: Inclusion Criteria:

* Spinal cord injury
* Erectile dysfunction
* No Medical Contraindication to use Avanafil and/or Sildenafil
* Able to provide informed consent
* Able to complete questionnaires

Exclusion Criteria:

* Medical Contraindication to use Avanafil and/or Sildenafil
* No spinal cord injury
* Congenital spinal cord injury
* Not able to provide informed consent
* Not able to complete questionnaires

Primary outcomes:
measure: IIEF-EF
timeFrame: 2 years
Secondary outcomes:
measure: SLQQ-Part II
timeFrame: 2 years
measure: GAQ
timeFrame: 2 years
Other outcomes:
Locations:
city: Toledo
country: Spain
facility: Hospital Nacional de Paraplejicos
Study officials:
References:
Clinical trial NCT02011282: Electro-Neuro-Muscular Stimulation in ICU
Official title: Electro-Neuro-Muscular Stimulation in Hospitalized Intensive Care Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myopathy
Neuropathy
Keywords: ICU,
MYOPATHY,
NEUROPATHY,
PNEUMONIA
Lead sponsor: University of Thessaly
Sponsor class: OTHER
First posted: 2013-12-13
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: We will examine whether the application of electro-neuro-muscular stimulation (ENMS) in critical care patients, can decrease the impact or severity of the critical illness myopathy (CIM) or neuropathy. We will also assess whether electro-neuro-muscular stimulation affect the incidence density rate of nosocomial pneumonia in the ICU.

Patients will be divided into two groups, Group A and Group B chosen at random. In Group A conventional physiotherapy will be applied while in Group B, ENMS will also be applied additional to physiotherapy, in the quadriceps muscles. The total time of applying ENMS will be 1 hour, it will be applied before the start of the physiotherapy per day of hospitalization and for 10 days in each patient.

The definition of CIM will be based on pathology muscular biopsy (quadriceps). Patients will undergo biopsy on the 1st and 11th day after entering the study. The technique of Gomori Trichrome will be used to determine the existence or absence of myopathy. In addition the ATPase technique will be applied at different prices of PH (PH: 9,4, PH: 4,6 and PH : 4.3), thus achieving a separation of myopathy and neuropathy.

The primary outcome of the study will be the incidence of myopathy in both groups, at day 12th. Considering that the incidence of myopathy in critically ill patients is 80% reducing this rate by 50% in the intervention group using statistical power equal to 0.80 up to a level of p \<0.05, 12 number of patients will be required in each group.


Eligibility criteria: Inclusion Criteria:

Patients aged\>18 years old and \<85 years old, hospitalized in the ICU for at least 96 hours

Exclusion Criteria:

pregnancy, autoimmune disease, pre-existing known neuromuscular diseases, presence of bone fractures on the lower extremities, use of corticoids

Primary outcomes:
measure: incidence of myopathy
timeFrame: 12 days
Secondary outcomes:
measure: NEUROPATHY
timeFrame: 12 days
Other outcomes:
measure: ventilator associated pneumonia
timeFrame: 28 days
Locations:
city: Larissa
country: Greece
facility: Icu University Hospital Larissa
state: Thessaly
Study officials:
affiliation: University of Thessaly
name: EPAMINONDAS ZAKYNTHINOS, PROF
role: STUDY_DIRECTOR
References:
Clinical trial NCT05685082: Teaching the Social Determinants of Health to Nursing Students With Simulation
Official title: Teaching the Social Determinants of Health to Nursing Students With Culturally Diverse Simulation: A Quasi Experimental Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Simulation of Physical Illness
Nurse's Role
Keywords: Nursing student
Simulation-based training
Standardized patient simulation
Manikin-based simulation
Lead sponsor: University of Massachusetts, Boston
Sponsor class: OTHER
First posted: 2023-01-13
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The goal of this intervention study is to compare two different simulation modalities (standardized patient and manikin-based) in nursing student education. The main aim is to determine the effect of new scenarios on cultural awareness levels in two different types of simulation modalities and to determine the effect of new scenarios on social determinants of health knowledge levels in two different types of simulation modalities.

Participants will assign to two groups and will attend simulation sessions.

Detailed description: The simulation session will contain prebriefing, simulation, and debriefing. The participants will be assigned to the simulation session.

* The first group will be the standardized patient group. They will ask to fill out the Cultural Awareness Scale and social determinants of health knowledge. Then, they will attend prebriefing, standardized patient simulation, and debriefing.
* The second group will be the manikin-based group. They will ask to fill out the Cultural Awareness Scale and social determinants of health knowledge. Then, they will attend prebriefing, manikin-based simulation, and debriefing.

Eligibility criteria: Inclusion Criteria:

* being enrolled in Nursing in the Community course
* accepting to be a participant
* accepting to be recorded

Exclusion Criteria:

* not attending at least one of the prebriefing, simulation, or debriefing sessions

Primary outcomes:
measure: Change from baseline cultural awareness level on the 36 questions Cultural Awareness Scale
timeFrame: Three hour
measure: Change from baseline social determinants knowledge on the 10 questions Social Determinants of Health Survey
timeFrame: Three hour
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: University of Massachusetts Boston
state: Massachusetts
Study officials:
affiliation: University of Massachusetts, Boston
name: Semiha Asli Bozkurt, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01727882: Automated Telephone Follow-up in the Swedish Prison and Probation Services
Official title: Automated Telephone Follow-up in the Swedish Prison and Probation Services. A Randomized Controlled Trail.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Affect
Alcohol Consumption
Substance Abuse
Keywords: Paroled offenders
Interactive Voice Response
Stress
Mental symptoms
Alcohol consumption
Substance use
Lead sponsor: Region Skane
Sponsor class: OTHER
Collaborators: name: Lund University
name: Malmö University
First posted: 2012-11-16
Enrollment: 108
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to investigate whether automated telephony may be used for daily assessments of paroled offenders, and whether a brief intervention based on these daily assessments may result in a more positive development compared to daily assessments only.

Detailed description: To study whether automated telephony could be used in paroled offenders to perform daily assessment of variables associated with recidivism in crime and to study the effects of a brief intervention based on these assessments during 30 days following probation.

Eligibility criteria: Inclusion Criteria:

* Convicted criminals subject to parole
* Access to a mobile telephone
* Assigned parole officer at parole

Exclusion Criteria:

* No knowledge of spoken Swedish
* Additional intervention such as intensive supervision with electronic monitoring, or in-patient care at a health and rehabilitation clinic

Primary outcomes:
measure: Mental symptoms, SCL-8D
timeFrame: During 30 days after probation
Secondary outcomes:
measure: Stress
timeFrame: During 30 days after probation
measure: Stress
timeFrame: During 30 days after probation
measure: Desire to use alcohol and drugs
timeFrame: During 30 days after probation
measure: Current use of alcohol and drugs
timeFrame: During 30 days after probation
Other outcomes:
Locations:
city: Norrköping
country: Sweden
facility: The Swedish Prison and Probation Services, Region South and Region East
Study officials:
affiliation: Lund university and Malmö university
name: Claes Andersson, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00374582: End Stage Liver Disease and Body Composition Assessment: Utilizing Bioelectric Impedance Analysis (BIA)
Official title: End Stage Liver Disease and Body Composition Assessment: Utilizing Bioelectric Impedance Analysis (BIA)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: End Stage Liver Disease
Keywords: Bioelectric impedance analysis
BIA
ESLD
LVP
Large volume paracentesis
Ascites
Liver
Hepatic
Lead sponsor: University of Cincinnati
Sponsor class: OTHER
First posted: 2006-09-11
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this research study is to see how effective bioelectric impedance analysis (BIA) is in determining body composition (the amount of fat versus muscle in the body) and nutritional status in patients with End Stage Liver Disease (ESLD)

Detailed description: The aim of this study is to report the validity of mBIA to determine body composition changes pre and post LVP (Large Volume Paracentesis)

* 18 years of age or older
* Cirrhotic patients with refractory ascites requiring LVP (a treatment to remove large volumes of excess fluid from the abdominal cavity)
* End Stage Liver Disease

Eligibility criteria: Inclusion Criteria:

* Patients with ESLD requiring LVP.
* Age over 18.
* Ability to provide written informed consent.

Exclusion Criteria:

* Organ retransplant candidates.
* Patient with use of any investigational agent within 30 days before LVP.
* Pregnant or lactating.
* Patients with non-bioprosthetic heart valves pacemakers, defibrillators, artificial joints, pins, plates, or other types of metal objects in the body.
* Amputations other than fingers or toes.

Primary outcomes:
measure: Efficacy and utility of BIA in determining body composition and nutritional status using multi-frequency machines in patients with ESLD and ascites requiring LVP.
timeFrame: Before and after large volume paracentesis
Secondary outcomes:
measure: Quantify the difference in BIA pre and post LVP to evaluate the impact of oncotic pressure in the assessment of total body composition.
timeFrame: Before and after large volume paracentis
Other outcomes:
Locations:
city: Cincinnati
country: United States
facility: University of Cincinnati
state: Ohio
Study officials:
affiliation: University of Cincinnati
name: Guy Neff, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01012882: Efficacy and Safety of Sublingual Immunotherapy (SLIT)
Official title: A Multicenter Randomized DBPC Trial to Evaluate Efficacy and Safety of Sublingual Immunotherapy (SLIT) With Allergen Extracts From Pollen in Patients With Seasonal Allergic Rhinitis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Allergic Rhinitis
Lead sponsor: Roxall Medizin
Sponsor class: INDUSTRY
First posted: 2009-11-13
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy and safety of specific sublingual immunotherapy (SLIT) with allergen extracts in patients suffering from seasonal allergic rhinitis .


Eligibility criteria: Inclusion Criteria:

* Positive history of allergen specific seasonal allergic rhinitis
* Positive screening skin prick test (wheal diameter \> 3 mm)
* Compliance and ability of the patient to complete a Diary Card for self-evaluating of the symptoms and antisymptomatic medication
* Signed and dated patient´s Informed Consent,

Exclusion Criteria:

* Previous immunotherapy within the last 3 years,
* Simultaneous participation in other clinical trials,
* Other reasons contra-indicating an inclusion into the trial according to the investigator´s estimation (e.g. poor compliance),
* Auto-immune disorders,
* Severe chronic inflammatory diseases,
* Malignancy,
* Alcohol abuse,
* Existing or intended pregnancy, lactation and/or lack of adequate contraceptive protection,
* Treatment with beta-blockers (incl. local application) and/or other contra-indicated drugs.

Primary outcomes:
measure: Symptom and medication score
timeFrame: 1 year
Secondary outcomes:
measure: Safety of the treatment
timeFrame: 1 year
measure: Documentation of adverse events
timeFrame: 1 year
measure: Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ)
timeFrame: 1 year
measure: Clinical global improvement
timeFrame: 1 year
Other outcomes:
Locations:
city: Hamburg
country: Germany
facility: Roxall Medizin
Study officials:
References: