Clinical trial NCT05954195: Effect of High Intensity Interval Training in Patients With Multiple Sclerosis
Official title: Effect of High Intensity Interval Training in Patients With Multiple Sclerosis: Systematic Review
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Multiple Sclerosis
Keywords: Multiple sclerosis AND high intensity interval training
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-07-20
Enrollment: 86
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: high intensity interval training starting by warm up period of 40 % from the HRmax then the interval exercise period of 85-90 % from HRmax ending by cool down period from 30 % of HRmax
Primary purpose: OTHER

Brief summary: In this study, we are aiming to systematically review the literature on the effect of HIIT on MS patients as improving physical performance, cognitive function, aerobic fitness and muscle strength. This could help guide the development of standardized clinical guidelines and direct clinical decision making by the physical therapists whether to implement this type of exercises or not.

Detailed description: Multiple sclerosis patients have considerably negative effects on the community and the national and international economy. Chronic symptoms of MS such as fatigue, cognitive impairments, emotional burden and diminished physical functioning considerably affect the daily lives of people with MS and may interfere with social and quality of life factors as friendships, family relationships and occupational status. HIIT has induced significant improvements in physiological conditioning in healthy and clinical populations, and might be appropriate for persons with MS. Recently, several RCTs have been published evaluating the effect of HIIT on MS patients. Consequently, this study will systematically review all these recent literature to direct the physiotherapists whether to implement this type of exercises or not.

Eligibility criteria: Inclusion Criteria:

* Studies: English full texts of RCTs only, Participants: multiple sclerosis patients with age from (20-50) years old irrespectively of sex, subtype of MS, race, diagnostic criteria, community or onset of the disease, Intervention: HIIT, any comparator.

Exclusion Criteria:

* Studies other than English full text RCTs, non adults younger than 20 years and older than 50 years, populations other than multiple sclerosis.

Primary outcomes:
measure: cognitive function
timeFrame: 8-12 weeks or less
Secondary outcomes:
measure: mental processing speed
timeFrame: 8-12 weeks or less
Other outcomes:
Locations:
city: Damietta
country: Egypt
facility: Azzarqa
Study officials:
affiliation: Physical therapy for neuromuscular disorders and its surgeries, Cairo university
name: Abeer Abobakr Dr Alwishy, Professor
role: STUDY_CHAIR
affiliation: Faculty of medicine, Alqasr elainy, Cairo university
name: Neveen Mohy-Eldin shalaby, professor
role: STUDY_CHAIR
affiliation: Faculty of physical therapy of neuromuscloskeletal disorders and its surgeries, Cairo universities
name: Hossam M. Elsaid, lecturer
role: STUDY_CHAIR
References:
citation: Zimmer P, Bloch W, Schenk A, Oberste M, Riedel S, Kool J, Langdon D, Dalgas U, Kesselring J, Bansi J. High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial. Mult Scler. 2018 Oct;24(12):1635-1644. doi: 10.1177/1352458517728342. Epub 2017 Aug 21.
citation: Langeskov-Christensen M, Grondahl Hvid L, Nygaard MKE, Ringgaard S, Jensen HB, Nielsen HH, Petersen T, Stenager E, Eskildsen SF, Dalgas U. Efficacy of High-Intensity Aerobic Exercise on Brain MRI Measures in Multiple Sclerosis. Neurology. 2021 Jan 12;96(2):e203-e213. doi: 10.1212/WNL.0000000000011241. Epub 2020 Dec 1.
citation: Spaas J, Goulding RP, Keytsman C, Fonteyn L, van Horssen J, Jaspers RT, Eijnde BO, Wust RCI. Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis. J Cachexia Sarcopenia Muscle. 2022 Oct;13(5):2537-2550. doi: 10.1002/jcsm.13050. Epub 2022 Aug 4.