Clinical trial NCT03354676: Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?
Official title: Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity, Metabolically Benign
Keywords: adipokines, metabolic syndrome, obese children
Lead sponsor: Romanian Society of Anesthesia and Intensive Care
Sponsor class: OTHER
Collaborators: name: University of Medicine and Pharmacy "Victor Babes" Timisoara
First posted: 2017-11-28
Enrollment: 122
Sex: ALL
Minimum age (years): 4
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: All children admitted to the Endocrinology, Diabetology and Cardiology Department who met the Inclusion Criteria

Brief summary: Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population

Detailed description: The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population.The current retrospective observational study was conducted at the "Louis Turcanu" Emergency Hospital Timisoara over a period of one year, from July 2013 and June 2014. All inborn patient files were analyzed as anonymised limited data sets from archived records of the Endocrinology, Diabetology and Cardiology department.

Eligibility criteria: Inclusion Criteria:

* obese children (BMI\> 95th percentile)

Exclusion Criteria:

* obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.

Primary outcomes:
measure: Defining obesity in the pediatric population
timeFrame: Weight and height were measured on day 1 of admission. Obesity was defined as a BMI > the 95th percentile.
measure: Leptin changes in the obese children with metabolic syndrome
timeFrame: Leptin levels were measured on day 1 of admission. Normal range was considered < 24ng/ml.
measure: Adiponectin changes in the obese children with metabolic syndrome
timeFrame: Adiponectin levels were measured on day 1 of admittance in children aged between 4 and18 years. Levels 4-26 mcg/ml were defined as normal values.
measure: Assessing cardiovascular risk in the obese children with metabolic syndrome
timeFrame: hsCRP levels were measured on day 1 of admittance in children aged between 4 and 18 years. Normal levels were considered between 0.1-2.8 mg/l
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Romanian Society of Anesthesia and Intensive Care
name: Alexandru Florin Rogobete, PhDS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Beyazit F, Unsal MA. Obesity and insulin resistance are significant predictors of serum leptin levels. J Turk Ger Gynecol Assoc. 2017 Sep 1;18(3):158-159. doi: 10.4274/jtgga.2017.0027. No abstract available.
citation: Lopez-Quintero A, Garcia-Zapien AG, Flores-Martinez SE, Diaz-Burke Y, Gonzalez-Sandoval CE, Lopez-Roa RI, Medina-Diaz E, Munoz-Almaguer ML, Sanchez-Corona J. Contribution of polymorphisms in the LEP, LEPR and RETN genes on serum leptin and resistin levels in young adults from Mexico. Cell Mol Biol (Noisy-le-grand). 2017 Aug 30;63(8):10-18. doi: 10.14715/cmb/2017.63.8.3.
citation: Bagherniya M, Khayyatzadeh SS, Heidari Bakavoli AR, Ferns GA, Ebrahimi M, Safarian M, Nematy M, Ghayour-Mobarhan M. Serum high-sensitive C-reactive protein is associated with dietary intakes in diabetic patients with and without hypertension: a cross-sectional study. Ann Clin Biochem. 2018 Jul;55(4):422-429. doi: 10.1177/0004563217733286. Epub 2017 Nov 23.