Clinical trial NCT03220373: Predicting Dropout and Outcome From Neuropsychological Functions in SUD Patients
Official title: Predicting Early Treatment Termination (Dropout) and Post-treatment Clinical Outcome From Neuropsychological Functions in Abstinent Substance Use Dependent (SUD) Patients
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Substance Use Disorder (SUD)
Keywords: Neuropsychology
Cognition
Drop-out
Follow-up
Lead sponsor: Oslo University Hospital
Sponsor class: OTHER
First posted: 2017-07-18
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Treatment seeking Substance Use Disorder (SUD) patients.

Brief summary: The aim of this project is to gain a more specific understanding of how different cognitive profiles predict residential treatment drop-out, treatment retention and post-treatment outcome in a population with Substance Use Disorder.

Detailed description: This project collects the neuropsychological profile of residential SUD patients, in addition to treatment length, exit reason, hospital journal data and post-treatment clinical outcome data. The project aims to identify clinically relevant neurocognitive domains that predict treatment dropout and post-treatment clinical outcome. This will make it possible for future clinicians to focus their effort on neurocognitive functions most relevant for this particular patient group.

RESEARCH QUESTIONS:

1. What neurocognitive domain (and sub-domain) are the strongest predictor of treatment drop-out and retention?
2. What neurocognitive domain (and sub-domain) are the strongest predictor of post-treatment clinical outcome variables such as drug use, health and social integration.
3. Will data on treatment length, age, gender, substance abuse history or psychiatric co-morbidity predict outcome independently, or in interaction with, the neuropsychological profile?

This longitudinal prospective cohort study aims for a continuous collection of neuropsychological data baseline and post-treatment follow-up data until 2030.

Eligibility criteria: Inclusion Criteria:

* Substance Use Disorder (SUD) patients.
* 18 years or older.
* Qualified to consent to research participation.
* Able to speak and write in Norwegian.

Exclusion Criteria:

* Not qualified to consent to research participation.
* Insufficient understanding of Norwegian.

Primary outcomes:
measure: Exit reason
timeFrame: On average 3 months
measure: Treatment retention
timeFrame: On average 3 months
Secondary outcomes:
measure: Substance use
timeFrame: 1 year after neuropsychological assessment
measure: Psychological distress
timeFrame: 1 year after neuropsychological assessment
measure: Quality of Life
timeFrame: 1 year after neuropsychological assessment
measure: ADHD symptoms
timeFrame: 1 year after neuropsychological assessment
measure: Income
timeFrame: 1 year after neuropsychological assessment
measure: Housing
timeFrame: 1 year after neuropsychological assessment
Other outcomes:
Locations:
city: Oslo
country: Norway
facility: Oslo University Hospital
Study officials:
affiliation: Oslo University Hospital
name: Espen Walderhaug, PhD
role: PRINCIPAL_INVESTIGATOR
References: