Clinical trial NCT06660095: Intraoperative "p50" Measurement in Liver Transplant Surgeries
Official title: "Investigation of the Clinical Predictive Value of p50 Value in Liver Transplant Surgeries"
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Liver Transplant; Complications
Keywords: Liver transplant
anesthesia
Blood gas analysis
Lead sponsor: Inonu University
Sponsor class: OTHER
First posted: 2024-10-26
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Liver transplant recipients who will undergo Elective Liver Transplant surgery at İnönü University Faculty of Medicine Liver Transplant Institute, ASA (American Society of Anesthesiology) score III-IV, patients between the ages of 18-65

Brief summary: The aim of this study is to compare the p50 value in routine blood gas measurements taken during liver transplant surgery follow-up with other follow-up parameters and clinical findings on the monitors, and to investigate whether there is a predictive parameter that can predict the rapidly changing clinical findings of the patients.

Detailed description: Blood gas monitoring is the most commonly method used by anesthetists during liver transplant surgeries. We evaluated the blood gas p50 value according to the stages in these heart transplant operations. We tried to find out how the blood gas p50 value would guide the patient's clinical findings in the dissection phase, anhepatic phase and neohepatic phase. For this purpose, we compared arterial and venous blood gas p50 values with the patient's vital signs at certain stages in liver transplant surgeries.

Eligibility criteria: Inclusion Criteria:

* Liver transplant recipients who will undergo Elective Liver Transplant surgery at İnönü University Faculty of Medicine Liver Transplant Institute, ASA (American Society of Anesthesiology) score III-IV, patients between the ages of 18-65

Exclusion Criteria:

* Patients with fulminant liver failure,
* hepatic encephalopathy,
* hepatorenal,
* hepatopulmonary syndrome,
* uncontrolled diabetes mellitus,
* cardiovascular, pulmonary disease,
* sepsis
* and patients who refuse consent in the informed consent form will be excluded from the study.

Primary outcomes:
measure: p50 changes during liver transplant surgery
timeFrame: T0: at the end of the dissection before clamps T1: 5 min. before reperfusion (anhepatic) T2: 30 min. after reperfusion of the liver graft (neohepatic) T3: after hepatic artery reperfusion T4: End of the operation
Secondary outcomes:
Other outcomes:
Locations:
city: Malatya
country: Turkey
facility: İnönü Üniversitesi Merkez Kampüsü (Elazığ Yolu 15.km) Battalgazi
Study officials:
affiliation: Inonu University
name: Muharrem UCAR, assoc.Prof.
role: STUDY_DIRECTOR
References:
citation: Kim Y, Jung JH, Kim GE, Park M, Lee M, Kim SY, Kim MJ, Kim YH, Kim KW, Sohn MH. P50 implies adverse clinical outcomes in pediatric acute respiratory distress syndrome by reflecting extrapulmonary organ dysfunction. Sci Rep. 2022 Aug 11;12(1):13666. doi: 10.1038/s41598-022-18038-6.
citation: Hall TH, Dhir A. Anesthesia for liver transplantation. Semin Cardiothorac Vasc Anesth. 2013 Sep;17(3):180-94. doi: 10.1177/1089253213481115. Epub 2013 Mar 12.