Clinical trial NCT04868929: The Brain Activation During Different Motor Patterns in Healthy Adults
Official title: The Brain Activation During Motor Execution, Motor Imagery, Action Observation, and Mirror Visual Feedback in Healthy Adults
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neurosciences
Keywords: brain activation
near infrared spectroscopy
motor imagery
action observation
mirror visual feedback
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2021-05-03
Enrollment: 43
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population in this study are heathly adults.

Brief summary: This study aims to investigate the brain activation during different motor patterns, including motor execution (ME), motor imagery (MI), action observation (AO) and mirror visual feedback (MVF). In addition, the relations between brain activation and motor performance will also be explored. This study includes two parts, which are upper limb and lower limb part. While executing all the tasks, brain activation in primary motor cortex(M1), premotor cortex(PMC), and supplementary motor cortex(SMA) will be monitored by functional near-infrared spectroscopy. One-way ANOVA with repeated measure will be used to detect the differences of brain activation level between each mode. Pearson correlation coefficient will be used to determine the relations of brain activation and motor performance.

Detailed description: In upper limb part, subjects will be instructed to execute functional reaching task in ME, MI, AO, and MVF mode. During ME mode, motor performance including maximum speed, maximum acceleration, and jerk will be collected simultaneously. In the lower limb part, subjects will be instructed to walking over ground in ME, MI, and AO mode. During ME mode, the temporal and spatial gait parameters, including speed, stride time, cadence, and stride length will be collected.

Eligibility criteria: * Inclusion Criteria

  1. Age between 20 to 30 years.
  2. Right-handed.
  3. Ability to walk 30 meters independently without an assistive device.
  4. No neurogical, cardiopulmonary, or muscle diseases that might interfere with the experiment.
  5. Mini-Mental State Examination (MMSE) score greater than 24.
* Exclusion Criteria 1. Physiological condition is unstable.

Primary outcomes:
measure: Brain activities over primary motor cortex
timeFrame: Day 1
measure: Brain activities over premotor cortex
timeFrame: Day 1
measure: Brain activities over supplementary motor area
timeFrame: Day 1
Secondary outcomes:
measure: Motor performance of upper limb -maximum speed
timeFrame: Day 1
measure: Motor performance of upper limb -maximum acceleration
timeFrame: Day 1
measure: Motor performance of upper limb - jerk
timeFrame: Day 1
measure: Motor performance of lower limb - gait speed
timeFrame: Day 1
measure: Motor performance of lower limb - cadence
timeFrame: Day 1
measure: Motor performance of lower limb - stride time
timeFrame: Day 1
measure: Motor performance of lower limb - stride length
timeFrame: Day 1
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University
name: Yanci Liu, PHD
role: PRINCIPAL_INVESTIGATOR
References: