Clinical trial NCT01720472: Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository
Official title: Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aging
Physical Functioning
Cognitive Functioning
Fitness
Keywords: Aging
Healthy Aging
Physical Performance
Physical Functioning
Cognitive Functioning
Fitness
Physical Activity
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2012-11-02
Enrollment: 1000
Sex: ALL
Minimum age (years): 30
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population will include 1,000 participants ages 30 and older living in Cabarrus County and/or the city of Kannapolis, or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina.

Brief summary: The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in order to develop a diverse cohort with specific physical and cognitive performance data paired with biological samples.

Detailed description: The MURDOCK Study, proposes this Horizon 2 study to collect a brief physical and cognitive performance assessment from 1,000 MURDOCK Registry participants. Blood sample aliquots will also be obtained. These physical and cognitive performance data, paired with -omics data from plasma and serum sample analyses, offer promise in the discovery of biomarkers for functional decline. This research will provide an important basis for our understanding of the physical, lifestyle, and genetic factors which, over the lifespan, contribute to changes in physical and cognitive capabilities as we age.

Eligibility criteria: Inclusion Criteria:

* A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina for 6 or more months of the year.
* Age 30 or older

Exclusion Criteria:

* Female that is currently pregnant
* Having had a heart attack, angina, congestive heart failure, or fluid in the lungs within the past 6 months
* Participant that requires consent by a legally authorized representative
* Participant that cannot walk 30ft without human assistance

Primary outcomes:
measure: Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository
timeFrame: Upto 2 years or 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Charlotte
country: United States
facility: Bethesda Health Center
state: North Carolina
city: Concord
country: United States
facility: McGill Family Medicine
state: North Carolina
city: Concord
country: United States
facility: Carolinas Medical Center NorthEast Medical Arts Building
state: North Carolina
city: Davidson
country: United States
facility: Ada Jenkins Center
state: North Carolina
city: Harrisburg
country: United States
facility: Harrisburg Sleep Center
state: North Carolina
city: Huntersville
country: United States
facility: Lake Norman Community Health Clinic
state: North Carolina
Study officials:
affiliation: Duke University
name: Miriam C Morey, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Parker D, Sloane R, Pieper CF, Hall KS, Kraus VB, Kraus WE, Huebner JL, Ilkayeva OR, Bain JR, Newby LK, Cohen HJ, Morey MC. Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood. J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):283-289. doi: 10.1093/gerona/gly121.