Clinical trial NCT06209073: Efficacy of Virtual Reality Exercises on Sarcopenia in Patients With Liver Transplantation
Official title: Efficacy of Virtual Reality Exercises on Sarcopenia in Patients With Liver Transplantation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Sarcopenia
Keywords: liver transplantation
virtual reality
quality of life
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-01-17
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: virtual reality and conventional treatment
Primary purpose: TREATMENT

Brief summary: This study will be conducted to investigate the effect of virtual reality exercises on hand grip strength, pinch strength, quadriceps muscle strength, exercise capacity, fatigue, and quality of life in patients with liver transplantation.

Detailed description: Liver transplantation (LT) continues to prove to be the best choice for curing patients with end-stage liver disease (ESLD) . Management strategies in peri-transplantation care have significantly improved the outcomes of patients after LT. One of the most challenging tasks of LT is defining which patients are clinically appropriate for this therapy. Evaluating disease severity for patients with ESLD is a serious challenge for liver transplant surgeons, and there is a critical need for better methods of risk stratification. The most common complications involved include ascites, hepatic encephalopathy, and variceal bleeding; however, severe muscle wasting or sarcopenia is the most common and frequently undiagnosed complications that negatively impact survival, quality of life, and response to stressors, such as infections and surgeries. Virtual reality (VR) is an interactive, 3-dimensional computer experience occurring in real time. It allows the users to participate in multisensory and multidimensional virtual environments . It provides the participants with real-time auditory, visual, and proprioception sensory feedback. It also provides a safe virtual exercise environment. sixty patients with liver transplantation will be assigned randomly to two groups; experimental group will receive virtual reality exercise plus traditional therapy for six weeks, control group will receive traditional therapy alone for six weeks

Eligibility criteria: Inclusion Criteria:

Sixty patients suffer from sarcopenia with liver transplantation. The age of patients ranges from (18:65) years. All patients must be conscious. Patients suffer from muscle weakness Patients suffer from fatigue Patients with low muscle endurance Patients' cases must be stable to deal with them

Exclusion Criteria:

Patients will be excluded if they have any of the following:

Any sign of acute rejection of the transplanted organ Acute hemorrhage Electrolyte imbalance Physiological instability Sever neurologic complication Sever cardiovascular co-morbidities

Primary outcomes:
measure: Hand grip strength
timeFrame: up to six weeks
Secondary outcomes:
measure: Pinch strength
timeFrame: up to six weeks
measure: Respiratory function
timeFrame: up to six weeks
measure: Fatigue
timeFrame: up to six weeks
measure: life disability
timeFrame: up to six weeks
measure: exercise capacity
timeFrame: up to six weeks
measure: quadriceps strength
timeFrame: up to six weeks
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Physical Therapy
Study officials:
affiliation: Cairo University
name: Sara A Elshrief, Bsc
role: PRINCIPAL_INVESTIGATOR
References: