louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06799208: Laparoscopic Approach in Adhesive Intestinal Obstruction
Official title: Evaluating the Efficacy of Laparoscopic Approach in Adhesive Intestinal Obstruction
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Efficacy of Laparoscopic Adhesiolysis
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-01-29
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients admitted to General Surgery department with adhesive intestinal obstruction during the year of study.

Brief summary: A Clinical trail to evaluate the efficacy of Laparoscopic approach in Adhesive Intestinal Obstruction .

Detailed description: There was a rapid growth of minimally invasive operations. Through its peritoneal tissue sparing character and minimal blood loss, laparoscopy was soon claimed to reduce adhesion formation and associated complications.

The aim of this prospective clinical trial study is to evaluate the use of laparoscopy in management of clinically diagnosed adhesive intestinal obstruction and the criteria of selection to get the best results .

Eligibility criteria: Inclusion Criteria:

* Patient who clinically diagnosed as adhesive intestinal obstruction.
* Both sexes
* Adult patients (above 18 years old

Exclusion Criteria:

* • Patient refused to participate in this study.

  * Patients not fit for laparoscopic surgery.

Primary outcomes:
measure: Number of days post- operative till passing stool .
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00481208: Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma
Official title: Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Open-Angle Glaucoma
Keywords: open-angle glaucoma
diurnal fluctuation
intraocular pressure
peripapillary retinal blood flow
latent asymmetric intraocular pressure
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2007-06-01
Enrollment: 70
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: NATURAL_HISTORY
Time perspective: OTHER

Brief summary: Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow may have distinctive patterns in medically well-controlled open-angle glaucoma patients. In the results, we found a unique pattern, 'Latent asymmetric IOP', defined as the IOP which differs between the eyes only when placed in the supine position. Unique effects of this latent asymmetric IOP on Visual field and diurnal IOP fluctuations were studied.

Detailed description: Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow have been implicated to be one of the important factors to affect visual field progression. However, there was no study to investigate them in medically well-controlled open-angle glaucoma patients. So we want to find the unique patterns.

Study 1. Subjects : Patients with medically well controlled open angle glaucoma Method : IOP and peripapillary retinal blood flow were measured for 24 hours. The relationship between the two were studied.

Study 2. Of the patients enrolled in study 1 , those on the same medical regimen for both eyes were analyzed for the presence of a latent asymmetric IOP and it's influence and association with visual field and diurnal IOP fluctuation.

Eligibility criteria: Inclusion Criteria:

* Open-angle glaucoma
* Topical anti-glaucoma medications

Exclusion Criteria:

* Ocular surgery history
* Other ocular disease history
* Oral glaucoma medications

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University College of Medicine
Study officials:
affiliation: Department of Ophthalmology, Yonsei University College of Medicine
name: Chan Yun Kim, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT05058508: LCI-PED-NOS-EXER-001: Exercise in Pediatric Oncology Patients
Official title: LCI-PED-NOS-EXER-001: Just Move. A Randomized Controlled Trial Investigating Exercise in Pediatric Oncology Patients
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Pediatric Cancer
Keywords: Exercise
Pediatric Oncology
Lead sponsor: Wake Forest University Health Sciences
Sponsor class: OTHER
Collaborators: name: Atrium Health Levine Cancer Institute
First posted: 2021-09-27
Enrollment: 60
Sex: ALL
Minimum age (years): 2
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to see if there are physical and emotional benefits to participating in a structured exercise regimen for those who are ages 2-25, are newly diagnosed with a blood or solid tumor cancer, and are currently undergoing or will begin cancer treatment.

Detailed description: This is a randomized, controlled trial to investigate if a structured exercise regimen will have benefit relative to the control arm by increasing and /or maintaining physical functioning in pediatric subjects undergoing chemotherapy and childhood cancer treatment as measured by 6-Minute Walk test and BOT-2 Brief or PDMS-2.

Eligibility criteria: Inclusion Criteria:

1. Ages 2-25 at time of consent
2. Subject has newly diagnosed cancer per Investigator, and is planning to undergo chemotherapy for treatment of malignancy for at least 3 full cycles
3. Ability of subject (and/or parent/guardian) to read and understand the English or Spanish language
4. As determined and documented by the enrolling investigator, ability of the subject to understand and comply with study procedures for the entire length of the study

Exclusion Criteria:

1. Known cardiac dysfunction that, in the opinion of the investigator, would be unsafe for the child to participate in the exercise program
2. Recent (within 4 weeks of enrollment) or planned surgery that will result in prolonged limited mobility not amendable to exercise modifications per investigator discretion
3. Primary CNS Tumor
4. Osteosarcoma

Primary outcomes:
measure: Potential benefit of increasing/maintaining physical functioning in pediatric subjects undergoing chemotherapy and childhood cancer treatment
timeFrame: 18 month period
measure: Potential benefit of increasing/maintaining physical functioning in pediatric subjects undergoing chemotherapy and childhood cancer treatment
timeFrame: 18 month period
Secondary outcomes:
measure: Adverse Event Rate
timeFrame: up to 18 months
measure: Quality of Life measured by the PedsQL Cancer Module
timeFrame: up to 18 months
measure: Subject adherence to exercise regimen
timeFrame: up to 18 months
measure: Adverse Events Related to Exercise Program
timeFrame: up to 18 months
Other outcomes:
Locations:
city: Charlotte
country: United States
facility: Levine Children's Hospital
state: North Carolina
Study officials:
affiliation: Wake Forest University Health Sciences
name: Jennifer Pope, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06235008: PAthwAy of Dyspneic patIent in Emergency in the North-east Region (North-East PArADIsE)
Official title: PAthwAy of Dyspneic patIent in Emergency in the North-east Region
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Dyspnea
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2024-01-31
Enrollment: 75000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with acute dyspnea cared by a medical team of the emergencies of CHRU of Nancy, CHR Metz-Thionville and CH d'Epinal

Brief summary: This is an observational retrospective multi-center study in patients managed for acute dyspnea by Emergency department medical team.

The main aim of the study is to evaluate factors associated with mortality risks in patients managed for acute dyspnea by an Emergency department medical team, overall, as well as in subgroups of interest (male/female, age categories, mode of admission and comorbidities).


Eligibility criteria: Inclusion Criteria:

* Man or women ≥ 18 years
* Patients with acute dyspnea cared by a medical team of the emergencies of CHRU of Nancy, CHR Metz-Thionville and CH d'Epinal.

Exclusion Criteria:

* Cardiorespiratory arrest before medical management by the Emergency Department team
* Adults under legal protection

Primary outcomes:
measure: All-cause mortality
timeFrame: Within 5 years following hospital discharge
Secondary outcomes:
measure: Main diagnosis during the initial hospitalization
timeFrame: Within hospital stay, maximum 21 days
measure: Mismatch between diagnosis in the Emergency department and at discharge
timeFrame: Within hospital stay, maximum 21 days
measure: Length of hospital stay
timeFrame: Within hospital stay, maximum 21 days
measure: Administration of non-invasive ventilation
timeFrame: Within hospital stay, maximum 21 days
measure: Timing of non-invasive ventilation
timeFrame: Within hospital stay, maximum 21 days
measure: Administration of diuretics
timeFrame: Within hospital stay, maximum 21 days
measure: Timing of diuretics
timeFrame: Within hospital stay, maximum 21 days
measure: Post emergency admission
timeFrame: Within hospital stay, maximum 21 days
measure: All-cause hospital mortality
timeFrame: Within hospital stay, maximum 30 days
measure: Readmissions (all-cause and related to acute dyspnea) to the emergency department
timeFrame: Within 5 years after admission
measure: Congestion score
timeFrame: Within 2 days of admission
Other outcomes:
Locations:
city: Nancy
country: France
facility: CHRU
Study officials:
References:
Clinical trial NCT04292808: Low Dose Methoxyflurane and Out-Patient Aesthetic Surgery and Facial Filler
Official title: An Open-Label Study to Assess the Efficacy and Safety of Low Dose Methoxyflurane (PENTHROX®) for Pain Control During Outpatient Aesthetic Surgeries and Facial Filler Injections
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Pain
Lead sponsor: Verso Surgery Centre
Sponsor class: OTHER
First posted: 2020-03-03
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The aim of the study is to generate real-world evidence on the effectiveness, safety and additional parameters of low dose methoxyflurane (PENTHROX®) in: aesthetic surgeries (eg. hair transplant, upper blepharoplasty, otoplasty, upper brow lift, and mentoplasty) and facial filler injections \[eg. hyaluronic acid (HA) and Sculptra®\] in an outpatient aesthetic practice. This will be an open-label study, with a total of 60 patients undergoing a planned outpatient aesthetic surgery or filler injection (30 patients in each group).


Eligibility criteria: Inclusion Criteria:

1. Conscious adult patients: ≥ 18 years of age
2. Patient is scheduled for an outpatient anesthetic surgery (eg. hair transplant, upper blepharoplasty, otoplasty, upper brow lift, and mentoplasty) or a facial filler injection (eg. HA, and Sculptra®).
3. Patient should understand the nature of the study and provide written informed consent
4. Patient is able to follow all study requirements and procedures and complete required questionnaires

Exclusion Criteria:

1. An altered level of consciousness, due to any cause, including head injury, drugs, or alcohol
2. Clinically significant renal impairment
3. Women of child bearing potential who are pregnant or peri partum, including labour
4. A history of liver dysfunction after previous methoxyflurane use or other halogenated anesthetics
5. Hypersensitivity to methoxyflurane or other halogenated anesthetics, or to butylated hydroxytoluene
6. Known or genetically susceptible to malignant hyperthermia or a history of severe adverse reactions in either patient or relatives
7. Clinically evident or potential hemodynamic instability as per the opinion of the investigator
8. Clinically evident respiratory impairment as per the opinion of the investigator
9. Prior treatment with PENTHROX® within 3 months

Primary outcomes:
measure: Assessing patient satisfaction
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Oakville
country: Canada
facility: Verso Surgery Centre
state: Ontario
Study officials:
References:
citation: Romagnoli A, Busque L, Power DJ. The "analgizer" in a general hospital: a preliminary report. Can Anaesth Soc J. 1970 May;17(3):275-8. doi: 10.1007/BF03004607. No abstract available.
Clinical trial NCT02524808: Prospective Identification and Validation of "BRCANess" Profile in Ovarian Epithelial Cancer
Official title: Multicentric Project for the Prospective Identification and Validation of Molecular Alterations That Define the "BRCANess" Profile in Ovarian Epithelial Cancer and Its Application as a Response Predictor to Platinum and Antitarget Therapies in the Clinical Practice. The Finding BRCANess Project
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Ovarian Neoplasms
Lead sponsor: Fundación de investigación HM
Sponsor class: OTHER
Collaborators: name: AstraZeneca
First posted: 2015-08-17
Enrollment: 230
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed with advanced epithelial ovarian cancer (stage 1c or higher) since 2008

Brief summary: This is an observational prospective study. Patients diagnosed with advanced epithelial ovarian cancer (stage IC or higher) since 2008 will be asked to participate in this study by signing an informed consent. Tumour samples will be reviewed to confirm the diagnosis and to select the best regions for tissue sampling to perform the following molecular studies: array-based Comparative Genomic Hybridization and Next Generation Sequencing. Detected mutations will be analysed by Sanger sequencing. FISH probes will be designed and tested on the samples.


Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with advanced epithelial ovarian cancer (stage IC or higher).

Exclusion Criteria:

* Non

Primary outcomes:
measure: Number of participants with a genetic profile defined by sequencing that could predict Progression Free Survival (PFS)
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Leganes
country: Spain
facility: Hospital Universitario Severo Ochoa
state: Madrid
city: Madrid
country: Spain
facility: Hospital Universitario HM Sanchinarro - Clara Campal Comprehensive Cancer Center
city: Madrid
country: Spain
facility: Hospital Universitario Ramón y Cajal
city: Pamplona
country: Spain
facility: Complejo Hospitalario de Navarra
Study officials:
References:
Clinical trial NCT05132608: Effect of a Social Media-based Health Education Program on Postnatal Care (PNC) Knowledge Among Pregnant Women Using Smartphones in Dhulikhel Hospital
Official title: Effect of a Social Media-based Health Education Program on Postnatal Care (PNC) Knowledge Among Pregnant Women Using Smartphones in Dhulikhel Hospital: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Unrecognized Condition
Lead sponsor: Kathmandu University School of Medical Sciences
Sponsor class: OTHER
First posted: 2021-11-24
Enrollment: 229
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Its an interventional study conducted to assess the effect of social media-based health education program on PNC knowledge among pregnant women attending Dhulikhel hospital, Nepal.

Detailed description: The study is a two-arm open-label randomized controlled trial conducted among literate pregnant visiting Dhulikhel hospital for ANC check-up. A computer-based program allocated 229 pregnant women owning smartphone with internet connectivity in a 1:1 ratio to either intervention (n=109) or usual care (n=120). The investigators assessed PNC knowledge in the participants by interviewing in-person or via phone; questionnaire was adopted from the previous study conducted to determine the knowledge of postnatal care among postpartum mothers in Asmara; that contained 20 knowledge questions with a maximum possible score of 61. The questionnaire was translated and pretested in Nepali, with the Cronbach alpa of 0.83. The intervention group received a 16 minutes video developed by using Health belief model via social media and the participants were reminded to view the video every week via telephone for a month. Control group received usual care. The primary outcome of the study was PNC knowledge score. The investigators utilized intent-to-treat analysis and measured the effect of the intervention on PNC knowledge score using linear regression analysis.

Eligibility criteria: Inclusion Criteria:

* literate pregnant women
* owned a smartphone
* used social media (either What's App, Viber, or Facebook)
* had internet connectivity (WIFI or mobile data)

Exclusion Criteria:

• learning difficulties(dementia) or vision impairment

Primary outcomes:
measure: PNC knowledge assessment
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Dhulikhel
country: Nepal
facility: Kalpana Chaudhary
state: Bagmati
Study officials:
References:
citation: Shaye R, Schwaninger B, Hoffman D. Activator construction simplified. J Clin Orthod. 1979 Nov;13(11):773-8. No abstract available.
Clinical trial NCT01915108: Optimal Effect-site Concentration of Remifentanil for Inhibiting Response to Laryngeal Mask Airway (LMA) Removal
Official title: Optimal Effect-site Concentration of Remifentanil for Inhibiting Response to Laryngeal Mask Airway (LMA) Removal During Emergence From Sevoflurane-remifentanil Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Respiratory Complication
Lead sponsor: Yeungnam University College of Medicine
Sponsor class: OTHER
First posted: 2013-08-02
Enrollment: 128
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study was designed to determine the optimal dose of remifentanil that can prevent the complications associated with the removal of LMA without delaying emergence.

Detailed description: Patients were randomly assigned to one of four groups. All patients received a predetermined effect-site concentrations (Ce) of remifentanil by target-controlled infusion (TCI) according to their group assignments (R0, remifentanil Ce of 0 ng/ml; R0.5, remifentanil Ce of 0.5 ng/ml; R1.0, remifentanil Ce of 1.0 ng/ml; R1.5, remifentanil Ce of 1.5 ng/ml) from 10 minutes before the end of surgery to LMA removal. Airway complications (airway obstruction, desaturation, breath holding, and coughing), nausea, and vomiting were assessed during the emergence phase.

Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists physical status 1 or 2
* undergoing lower extremity surgery under general anesthesia

Exclusion Criteria:

* suspected difficult airways
* respiratory disease (chronic obstructive pulmonary disease, upper respiratory infection)
* body mass index \> 30 kg/m2
* allergies to the study drugs
* a history of gastric reflux

Primary outcomes:
measure: Number of Patients With Adverse Events Following LMA Removal
timeFrame: from the end of surgery until arrival in the post-anesthetic care unit, an expected average of 15 minutes.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Department of Anesthesiology and Pain Medicine, College of medicine, Yeungnam University, Daemyung-Dong, Nam-Gu, Daegu, Republic of Korea
name: sangjin park, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05204108: Preoperative Detection of Muscle Invasion in Bladder Cancer with Contrast-enhanced Ultrasonography
Official title: Evaluation of the Preoperative Detection of Muscle Invasion in Bladder Cancer with Contrast-enhanced Ultrasonography: a Prospective Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Bladder Cancer
Keywords: Bladder Cancer
Contrast-enhanced Ultrasonography
Lead sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2022-01-24
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients who have a histologically or cytologically confirmed diagnosis of primary bladder cancer

Brief summary: To evaluate the diagnostic accuracy of CEUS for the preoperative staging of bladder cancer, which would benefit the implementation of efficient therapeutic strategies.

Detailed description: Bladder cancer can be grouped into non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancers (MIBC), the latter displaying high aggressiveness, a high degree of malignancy, complicated treatment, high propensity to metastasis, and poor prognosis. Currently, the clinical feasibility and accuracy of preoperative detection of muscle invasion in bladder cancer with contrast-enhanced ultrasonography (CEUS) are unclear.

To evaluate the diagnostic accuracy of CEUS for the preoperative staging of bladder cancer, which would benefit the implementation of efficient therapeutic strategies.

Eligibility criteria: Inclusion Criteria:

* (a) eligible patients should be 18-year-old or older;
* (b) patients should have a histologically or cytologically confirmed diagnosis of primary bladder cancer;
* (c) patients should not have had any surgery, chemotherapy, immunotherapy, or any therapy before CEUS diagnosis.

Exclusion Criteria:

* (a) participants with confirmed to have no carcinoma of the bladder;
* (b) participants with previous pelvic surgery, who had undergone therapy, any bladder surgery, or had received chemotherapy, radiotherapy or immunotherapy;
* (c) participants diagnosed with tumor recurrence or metastasis; (d) participants who were allergic to ultrasound contrast agents or could not tolerate CEUS examination, for instance, with recent myocardial infarction, angina pectoris, cardiac insufficiency, severe cardiac arrhythmia, a right/left cardiac shunt, severe pulmonary hypertension, uncontrolled systemic hypertension, acute respiratory distress syndrome, or chronic obstructive pulmonary disease.

Primary outcomes:
measure: Detection of Muscle Invasion in Bladder Cancer
timeFrame: within 3 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Sun Yat-sen Memorial Hospital, Sun Yat-sen University
state: Guangdong
Study officials:
affiliation: Department of Ultrasound in Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
name: Baoming Luo, master
role: PRINCIPAL_INVESTIGATOR
References: