Clinical trial NCT03953872: Antihypertensives in Non-cardiac Surgical Population
Official title: Current Status of Antihypertensive Drug Treatment in Non-cardiac Surgical Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Perioperative Antihypertensive
Lead sponsor: RenJi Hospital
Sponsor class: OTHER
First posted: 2019-05-17
Enrollment: 351
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients undergoing elective non-cardiac surgery in Renji hospital

Brief summary: A cohort of hypertension patients undergoing elective non-cardiac surgery was constructed to investigate current status of antihypertensive drug treatment in non-cardiac surgical population.

Detailed description: Perioperative changes in blood pressure (BP) are associated with perioperative risks. However, there is little information regarding the current status of antihypertensive treatment in non-cardiac surgical population. A cohort of 351 hypertension patients aged between 18 to 85-year old undergoing elective non-cardiac surgery was constructed to investigate the application of antihypertensive drugs, systemic involvement, perioperative hemodynamics and internal environment to grasp the perioperative impact of different antihypertensive drugs, and to further provide a reference for the preoperative antihypertensive strategy of surgery patients.

Eligibility criteria: Inclusion Criteria:

* patients undergoing elective non-cardiac surgery with hypertension(i.e., with a systolic blood pressure(SBP) of \>=140 mmHg and/or a diastolic blood pressure(DBP) of \>=90 mmHg based on the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure) or self-reported use of antihypertensive medication

Exclusion Criteria:

* Patients under the age of 18 years old
* Patients more than 85 years old
* Patients suspected of intracranial hypertension

Primary outcomes:
measure: perioperative blood press(BP)
timeFrame: from the moment on arrival to the operating room until the moment leaving PACU, assessed up to 240 minutes.
Secondary outcomes:
measure: pH, base excess, and concentration of HCO3- in blood gases
timeFrame: 5 minutes after extubating in PACU
measure: the incidence of hypotension in PACU
timeFrame: from the moment on arrival to PACU until 60 minutes after arriving or the moment leaving PACU, whichever came first, assessed up to 240 minutes.
measure: the incidence of hypertension in PACU
timeFrame: from the moment on arrival to PACU until 60 minutes after arriving or the moment leaving PACU, whichever came first, assessed up to 240 minutes.
measure: hospitalization days
timeFrame: from the date of admission until the date of discharge or date of death from any cause, whichever came first, assessed up to 100 days
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Renji Hospital, Shanghai Jiao Tong University, School of Medicine
state: Shanghai
Study officials:
affiliation: Renji Hospital, School of Medicine, Shanghai Jiaotong University, China
name: Jie Chen, M.S.
role: STUDY_CHAIR
References: