louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05024682: Pulsed Radiofrequency Versus Pulse Dose Pulsed Radiofrequency of the Pudendal Nerve in Patients With Pudendal Neuralgia
Official title: Pulsed Radiofrequency Versus Pulse Dose Pulsed Radiofrequency of the Pudendal Nerve in Patients With Pudendal Neuralgia
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pain, Chronic
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2021-08-27
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The relatively complex anatomical structure of the pelvis has been a focus of study in the medical field. The diagnosis of the causes of chronic pelvic pain is usually a complicated process.

Pudendal neuralgia is a syndrome that is characterized by pelvic pain, including bowel, bladder regional pain or discomfort, sexual dysfunction, severe burning sensations and needle-like pain, which are aggravated when seated and relieved after standing. pudendal neuralgias are induced by pudendal nerve damage The mechanism of PRF has been studied repeatedly. It has been verified that PRF has definite safe treatment range, but during the PRF treatment, the tissue surrounding the electrode may have some degree of change and so it is difficult to assess any actual damage.7 Based on electric field intensity, PRF can actually produce tissue changes observable as in vitro changes to ultrastructure in early-phase histologic study. These biological changes were converted to biological effect to alleviate neuropathic pain in animal models.


Eligibility criteria: Inclusion Criteria:

* pain located in the pudendal nerve distribution area
* pain intensity increases in the sitting position;
* no nocturnal pain symptoms;
* pain with no objective sensory impairment
* pain is relieved by diagnostic pudendal
* the pain symptom is associated with sexual dysfunction, with the elimination of obstetrical and gynaecologic, urological and anorectal diseases in the related departments and absence of any physical and mental disorders;
* treatment by other departments is invalid;
* patients should be older than 18 years
* patients should be able to sign an informed consent form

Exclusion Criteria:

* patients have simple tailbone, gluteus muscle or lower abdominal pain, or only paroxysmal pain, or only pruritic symptoms, and/or have imaging anomalies that may explain the symptoms;
* female patients who are pregnant;
* patients who take anticoagulant drugs or have any coagulation disorder;
* patients who are unable to complete the questionnaire;
* patients with pain, which is caused by malignant or autoimmune diseases and
* patients who are hypersensitive to metals.

Primary outcomes:
measure: visual analogue score
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Saeid Metwaly Elsawy
Study officials:
References:
Clinical trial NCT05319782: Long-term Assesment of Patients Operated for Hypospadias in Their Childhood : Urinary, Aesthetical, Sexual and Psycho-social Consequences
Official title: Long-term Assesment of Patients Operated for Hypospadias in Their Childhood : Urinary, Aesthetical, Sexual and Psycho-social Consequences
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hypospadias
Lead sponsor: Centre Hospitalier Universitaire de Besancon
Sponsor class: OTHER
First posted: 2022-04-08
Enrollment: 66
Sex: MALE
Minimum age (years): 18
Maximum age (years): 23
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The purpose of this study is to assess the long term urinary, sexual, cosmetic and psycho-social outcomes of adult patients operated for hypospadias during childhood


Eligibility criteria: Inclusion Criteria:

* Patients operated for hypospadias during childhood (before the age of 15) at the University Hospital of Besançon (France)

Exclusion Criteria:

* Patients with a non-operated hypospadias
* Opposition to participate
* Legal incapacity

Primary outcomes:
measure: Proportion of adult patients with urethral stenosis following a repair surgery performed during childhood
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Besançon
country: France
facility: CHU de Besançon
Study officials:
affiliation: CHU De Besançon
name: Yann CHAUSSY, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03657082: Effects of PEP on IC During IT in Patients With COPD
Official title: Effects of Positive Expiratory Pressure on Inspiratory Capacity and Dyspnea in Patients With COPD During Exercise
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Chronic Obstructive Pulmonary Disease
Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2018-09-04
Enrollment: 1
Sex: ALL
Minimum age (years): 45
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This study will investigate the effects of positive expiratory pressure (PEP) on hyperinflation in patients with chronic obstructive pulmonary disease (COPD). Inspiratory capacity (IC) is the primary outcome

Detailed description: This is a cross-over intervention assessing the effect of PEP on IC and dyspnea in patients with COPD performing an interval training (IT) session.

IC will be measured before, during and immediately after the IT session. Each participant will receive perform IT sessions including either the use of a PEP of 10 cmH2O or a PEP of 1 cmH2O. The effects on IC and dyspnea on both PEP levels will be assessed.

Eligibility criteria: Inclusion Criteria:

* Stable COPD since 1 month at least
* Able to understand the instructions

Exclusion Criteria:

* COPD with a forced expiratory volume at one second \> 80% of predicted values
* In exacerbation
* Orthopedic of neurological condition likely to interfere with the experimentation
* Contraindication to perform exercise

Primary outcomes:
measure: Change in inspiratory capacity
timeFrame: 20 minutes
Secondary outcomes:
measure: Change in Borg scale
timeFrame: 20 minutes
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Cliniques universitaires Saint-Luc
Study officials:
References:
Clinical trial NCT02045082: The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis
Official title: Comparison Between the Sensibility of the Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Herpes Simplex Keratitis
Keywords: Flocked swab
Traditional fiber swab
Herpes simplex epithelial keratitis
Quantitative PCR
Lead sponsor: CHU de Quebec-Universite Laval
Sponsor class: OTHER
First posted: 2014-01-24
Enrollment: 146
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to compare a corneal sampling realized by a flocked swab (flocked swab regular 519CS01) with a sampling by traditional fiber swab (Copan regular swab 164KS01 in polyester). Their impact on the sensibility of the viral culture in the Herpes simplex epithelial keratitis will be the primary objective of this study.

Detailed description: In our center, the flocked swabs became an important tool in the corneal sampling for viral keratitis, replacing rightly or wrongly the former traditional fibers swab. No research was specifically designed to study the corneal taking with these swabs. Nevertheless, numerous reasons would motivate it, because of the peculiarities in ophthalmology: the corneal sampling has to be made with the slit lamp rather than in a macroscopic manner; the corneal lesion are often millimetre-length and confined; the histology of the cornea is unique and compares only imperfectly with other structures of the human body like the nasal mucosa. In these circumstances, the properties of the stalk (rigidity, length) and of its extremity (roughness, textures, absorbance) can influence the quality of the sampling and the final result of the culture.

Eligibility criteria: Inclusion Criteria:

* Slit lamp signs at the initial examination that are compatible with an Herpes simplex epithelial keratitis (Herpes simplex dendrite, herpes simplex geographic ulcer)

Exclusion Criteria:

* Topical or systemic antiviral Therapy during the last 14 days Patient with Herpes simplex stromal keratitis without epithelial involvement Herpetic lesion outside the cornea

Primary outcomes:
measure: Result of the culture
timeFrame: 1 month after the initial visit
Secondary outcomes:
measure: Time before positivity of the culture
timeFrame: 1 month after the initial visit
measure: Viral load concentration
timeFrame: 1 month after the initial visit
Other outcomes:
Locations:
city: Québec
country: Canada
facility: Centre universitaire d'ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec
state: Quebec
Study officials:
affiliation: Centre de recherche du CHU de Québec; Université Laval
name: Patricia-Ann Laughrea, MD, CRMC(C)
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05766982: Kerecis Fish Skin Grafts With and Without Platelet Rich Plasma (PRP)
Official title: Fish Skin Grafts With Platelet-rich Plasma Compared to Fish Skin Grafts for Chronic Wound Healing: Randomized, Prospective Trial
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Non-healing Wound
Keywords: xenograft
PRP
platelet rich plasma
Lead sponsor: St Elizabeth Healthcare
Sponsor class: OTHER
First posted: 2023-03-13
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This study will be a 1:1 randomized controlled trial with parallel group assignment.
Primary purpose: TREATMENT

Brief summary: This prospective, randomized pilot study compares the use of a xenograft with PRP to a xenograft alone for chronic, nonhealing wounds.


Eligibility criteria: Inclusion Criteria:

* Patient is over the age of 18 years;
* The targeted wound is deemed a chronic, nonhealing wound after six weeks of treatment; - - Patient of Dr. Eldridge, Dr. Glenn, or Dr. Worley;
* Target wound size must be between 2 cm x 2 cm x 0.1 cm deep and 10 cm x 10 cm x 5 cm deep;
* Surgical candidate for standard of care Kerecis® xenograft surgery.

Exclusion Criteria:

* Patient with hemoglobin values less than 6.9 g/dL drawn at least 30 days prior to the Kerecis® xenograft surgery;
* Patient with a known allergy or other sensitivity to fish material;
* Patient is currently undergoing chemotherapy or radiation therapy;
* The targeted wound is of autoimmune origin; and Non-English-speaking patients.

Primary outcomes:
measure: Time to wound being deemed healed or 6 months
timeFrame: 6 months
Secondary outcomes:
measure: Wound quality of life
timeFrame: 6 months
Other outcomes:
Locations:
city: Edgewood
country: United States
facility: St. Elizabeth Healthcare Edgewood
state: Kentucky
Study officials:
References:
Clinical trial NCT03367182: Real-World Effectiveness of Bevacizumab Based on AURELIA in Platinum-resistant Recurrent Ovarian Cancer
Official title: Real-World Effectiveness of Bevacizumab Based on AURELIA in Platinum-resistant Recurrent Ovarian Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ovarian Cancer
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2017-12-08
Enrollment: 50
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with epithelial ovarian cancer, fallopian tube carcinoma or primary peritoneal carcinoma with desease progression within 6 months of platinum treatment.

Brief summary: This study will evaluate the efficacy and safety profile, response rate, progression free survival, overall survival of bevacizumab (Avastin) added to chemotherapy in patients with epithelial ovarian cancer, fallopian tube carcinoma or primary peritoneal carcinoma with disease progression within 6 months of platinum treatment.


Eligibility criteria: Inclusion Criteria:

1. Patients who have histologically or cytologically confirmed recurrent epithelial ovarian cancer, fallopian tube cancer, or peritoneal cancer.
2. Patients who have platinum-resistant disease (defined as having relapsed within 6 months of her last platinum-containing regimen)
3. Patients who have underwent chemotherapy of either weekly paclitaxel + bevacizumab, topotecan + bevacizumab, pegylated liposomal doxorubicin + bevacizumab in 2nd line or 3rd line chemotherapy.

Exclusion Criteria:

1. Patients with previous treatment with bevacizumab.
2. Patients who received bevacizumab combination therapy in 4th line or more chemotherapy.

Primary outcomes:
measure: Progression free survival (PFS)
timeFrame: 36 months
measure: Incidence of Treatment-Emergent Adverse Events
timeFrame: 36 months
Secondary outcomes:
measure: Response rate
timeFrame: 36 months
measure: overall survival (OS)
timeFrame: 36 months
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance hospital
Study officials:
References:
citation: Lee JY, Park JY, Park SY, Lee JW, Kim JW, Kim YB, Jeong DH, Lee KB, Kim TH, Lee IH, Choi MC, Kim KH, Kim YM, Lee YJ, Kang S; KGOG Investigators; Pujade-Lauraine E. Real-world effectiveness of bevacizumab based on AURELIA in platinum-resistant recurrent ovarian cancer (REBECA): A Korean Gynecologic Oncology Group study (KGOG 3041). Gynecol Oncol. 2019 Jan;152(1):61-67. doi: 10.1016/j.ygyno.2018.10.031. Epub 2018 Nov 6.
Clinical trial NCT06076382: Endoscopic Ultrasound Guided Colorectal ESD and Traditional Colorectal ESD Surgery
Official title: A Prospective Randomized Controlled Study Protocol Between Endoscopic Ultrasound Guided Colorectal ESD and Traditional Colorectal ESD Surgery
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Colorectal Endoscopic Submucosal Dissection(ESD) Surgery
Keywords: colorectal
Endoscopic submucosal dissection
ultrasound
Lead sponsor: Jilin University
Sponsor class: OTHER
First posted: 2023-10-10
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A prospective randomized controlled study protocol between endoscopic ultrasound guided colorectal ESD and traditional colorectal ESD surgery

Detailed description: This study compare and analyze the efficiency of endoscopic ultrasound guided colorectal ESD surgery with traditional colorectal ESD surgery, in order to guide colorectal ESD operations.

Eligibility criteria: Inclusion Criteria:

* Cases in our hospital who require colorectal ESD surgery
* Colorectal lesions（laterally spreading tumor）.

Exclusion Criteria:

* Laterally spreading tumor but not nodular mixed type(LST-G-M)
* Patients who have participated or are currently participating in other clinical trials within the first 4 weeks of enrollment;

Primary outcomes:
measure: operating time
timeFrame: During surgery
measure: Measure the area of the lesion
timeFrame: During surgery
Secondary outcomes:
measure: Number of propria muscle layer injuries during surgery
timeFrame: During surgery
measure: Time to first fluid diet
timeFrame: one week after surgery
measure: Complete resection rate
timeFrame: 1 year
Other outcomes:
Locations:
city: Chang chun
country: China
facility: the First Hospital of Jilin University
state: Ji Lin
Study officials:
References:
Clinical trial NCT01512082: The Effect of Reducing Soreness in Marathon Runners
Official title: The Effect of Pulsed Electromagnetic Field Therapy in Reducing Delayed Onset Muscle Soreness in Marathon Runners. A Double-blind Randomized Placebo-controlled Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Contracture of Muscle, Thigh
Keywords: Pain
Delayed onset muscle soreness
Pulsed electromagnetic field
Marathon
Lead sponsor: Northern Orthopaedic Division, Denmark
Sponsor class: OTHER
First posted: 2012-01-19
Enrollment: 47
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Delayed onset muscle soreness is defined as the sensition of pain and discomfort in skeletal muscles that occurs after eccentric muscle actions or strenuous exercise like a marathon.

Detailed description: There is a growing body of clinical evidence which shows that noninvasive, nonpharmacologic pulsed electromagnetic fields have many clinical effects. Pulsed electromagnetic fields have shown to reduce pain in different groups of patients. This concerns patients with osteoarthritis, rheumatoid arthritis, diabetic neuropathy, fibromyalgia, distal radius fractures, pelvic pain and postoperative patients.

A marathon is a muscular strain. Physiologic effects of a marathon involves muscular and connective tissue damage which initiates an inflammatory response as well as release of metabolic factors like lactate and free radicals, intracellular metabolites and by-products of proteolysis.

The objective of this study was to investigate the efficacy of pulsed electromagnetic fields compared to placebo in reducing delayed onset muscle soreness in marathon runners.

Eligibility criteria: Inclusion Criteria:

* Completion of a marathon
* Age \> 18 years

Exclusion Criteria:

- Unable to read and speak Danish

Primary outcomes:
measure: Thigh pain by walking
timeFrame: 5 days
Secondary outcomes:
measure: Registration of injuries and symptoms from the musculoskeletal system.
timeFrame: 5 days
Other outcomes:
Locations:
city: Aalborg
country: Denmark
facility: Orthopaedic Surgery Research Unit, Aalborg University Hospital
Study officials:
affiliation: Northern Orthopaedic Division, Aalborg University Hospital, Denmark
name: Sten Rasmussen, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04008082: A Study of Overall Survival in Participants With Unresectable Hepatocellular Carcinoma
Official title: Specific Use Results Survey of LENVIMA 4 mg Capsules -Observational Study of Overall Survival in Patients With Unresectable Hepatocellular Carcinoma (Study LEN03T)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms
Keywords: Hepatocellular Carcinoma
Lenvatinib Mesilate
Lenvima
LEN03T
Lead sponsor: Eisai Inc.
Sponsor class: INDUSTRY
First posted: 2019-07-05
Enrollment: 412
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants with unresectable hepatocellular carcinoma will be observed for specific use results survey of lenvima 4 mg capsules.

Brief summary: The primary purpose of this study to continue follow-up of participants enrolled in the study E7080-M081-504 (NCT03663114) of lenvima capsules and to evaluate the overall survival of participants with hepatocellular carcinoma.


Eligibility criteria: Inclusion Criteria:

- All participants enrolled in the study E7080-M081-504 with informed consent to participate in this study.

Exclusion Criteria:

* Participants who do not have unresectable hepatocellular carcinoma
* Participants who have not given informed consent or have withdrawn consent to participation
* Participants with a history of hypersensitivity to any ingredient of lenvima
* Pregnant or possibly pregnant women
* Participants previously treated with lenvima (excluding those previously enrolled in the Study E7080-M081-504 \[NCT03663114\] at another clinical site).

Primary outcomes:
measure: Overall Survival (OS)
timeFrame: From date of study drug administration until date of death from any cause (approximately 2.8 years)
measure: Presence or absence of factors with a possible influence on OS
timeFrame: From date of study drug administration until date of death from any cause (approximately 2.8 years)
Secondary outcomes:
Other outcomes:
Locations:
city: Osaka
country: Japan
facility: Eisai Trial Site #1
city: Tokyo
country: Japan
facility: Eisai Trial Site #2
Study officials:
References:
Clinical trial NCT02936882: Evaluation of Antral Ultrasonography for Full Stomach Diagnosis Before Pediatric Surgical Emergencies
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Gastric Content
Full Stomach Status
Keywords: ultrasonography
aspiration
emergency
children
antrum
Lead sponsor: Hôpital Necker-Enfants Malades
Sponsor class: OTHER
First posted: 2016-10-18
Enrollment: 50
Sex: ALL
Minimum age (years): 3
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This study evaluates antral ultrasonography for the diagnosis of full stomach before surgical emergencies in pediatric population. Preoperative ultrasonographic antral evaluation is compared to peroperative gastric aspirate with nasogastric tube.


Eligibility criteria: Inclusion Criteria:

* Surgical emergency procedure
* ASA I-II

Exclusion Criteria:

* Ultrasound antrum assessment not possible
* No nasogastric tube during surgery
* Vital emergency
* Patient from Critical Care Ward
* Time between ultrasound assessment and gastric content collecting up to 20min
* Child and/or Parents doesn't/don't want to participate in the study
* Personal medical history of gastric or oesophagus desease

Primary outcomes:
measure: Volume of gastric content aspirated throw nasogastric tube
timeFrame: 20 min
Secondary outcomes:
measure: Grades as described by Perlas et al. for ultrasonographic qualitative evaluation of gastric content
timeFrame: 20 min
measure: relationship between peroperative gastric content and ultrasonographic antrum assessment
timeFrame: 20 min
measure: Time to perform antral ultrasonography
timeFrame: 20 min
measure: Quality of image obtained during antral ultrasonography
timeFrame: 20 min
measure: Child behaviour during antral ultrasonography
timeFrame: 20 min
measure: Number of participants with exploitable antral ultrasonography
timeFrame: 20 min
measure: Reasons for antral ultrasonography failure
timeFrame: 20 min
Other outcomes:
Locations:
city: Paris
country: France
facility: Necker Enfants-Malades University Hospital - APHP
Study officials:
References: