Clinical trial NCT04492046: Complex Decongestive Applications in Patients With Lipedema
Official title: The Effect of Complex Decongestive Applications on Lower Extremity Limb Volume in Patients With Lipedema
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lipedema
Keywords: Lipedema
Manual lymph drainage
Complex Decongestive Physiotherapy
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2020-07-30
Enrollment: 23
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients included in this study consisted of those who had a diagnosis of lipedema in the lower extremities, between the ages of 18-65.

Brief summary: Lipedema is a rare condition which almost exclusively affects women. The disease is characterized with bilateral, symmetric abnormal accumulation of subcutaneous fat and is often mistaken for simple obesity. In most patients, the hips, buttocks, thighs, knees, and lower legs are affected. Upper extremity involvement has been reported to be present in 80% patients. The hands and feet are never affected. The accumulation of subcutaneous fat and edema results in tenderness, sensitivity to touch and pressure and also pain. Patients also tend to bruise easily even after a minimal trauma. It has been reported that the complaint of pain increases with aging.There is no known cure for lipedema. However, conservative treatment with physiotherapy, manual lymph drainage and compression, also known as complex decongestive physiotherapy is used worldwide as a standard treatment regimen . The aim of this study is to investigate the effect of complex decongestive applications on lower extremity limb circumference and volume in patients with lipedema.

Detailed description: All participants included in the study were included in a treatment protocol consisting of complex decongestive physiotherapy Each patient received;

1. 45 minutes of manual lymph drainage on both lower extremities,
2. Moisturisation of the lower extremities,
3. Bandage application

Alongside this routine, the patients were advised to exercise (walk) regularly every day.

This treatment routine was continued until the patients were discharged from the clinic.

Eligibility criteria: Inclusion Criteria:

* Being willing to participate in the study
* Being 18-65 years old
* Having a diagnosis of lower extremity lipedema

Exclusion Criteria:

- Having edematous disease in the lower extremity such as lymphedema or chronic venous insufficiency

Primary outcomes:
measure: Limb Volume
timeFrame: Change from Baseline limb volume at 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazi University
state: Çankaya
Study officials:
affiliation: Gazi University
name: Gokhan Yazici, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Volkan-Yazici M, Yazici G, Esmer M. The Effects of Complex Decongestive Physiotherapy Applications on Lower Extremity Circumference and Volume in Patients with Lipedema. Lymphat Res Biol. 2021 Feb;19(1):111-114. doi: 10.1089/lrb.2020.0080. Epub 2020 Oct 30.