louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04388423: Study on Application of Simulated Training in Ultrasound Guided Transversus Abdominis Plane Block
Official title: Study on Application of Simulated Training in Ultrasound Guided Transversus Abdominis Plane Block
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Transversus Abdominis Plane Block
Simulation Training
Learning Curve
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
First posted: 2020-05-14
Enrollment: 240
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: With the development of society and the enhancement of people's awareness of law and self-protection, it is necessary to use simulation technology to create a simulated human and clinical environment to replace the traditional teaching of clinical operation on real patients. So simulation teaching is more and more important in medical education. However, simulation teaching is in the ascendant in China, especially in the ultrasound-guided nerve block, limited by the lack of full simulation of puncture model, the simulation training of ultrasound-guided nerve block is not carried out much. Therefore, this study uses simulation training to carry out ultrasound-guided horizontal abdominal muscle block teaching, in order to explore an effective way of ultrasound-guided nerve block teaching.


Eligibility criteria: Inclusion Criteria:

* 18-70 years old; ASA 1 \~ 2; patients under non-transvaginal gynecologic surgery, rectal surgery or descending colon surgery

Exclusion Criteria:

* Patients with communication disorder Central or peripheral nervous system diseases. Liver and kidney functions seriously damaged Coagulation function abnormality and local anesthetic allergy history Patients with serious heart disease, hypertension and diabetes. Patients who have used analgesic drugs or drugs that may affect cardiovascular function within 24 hours before operation.

Patients with infection at the puncture site.

Primary outcomes:
measure: The time taken to complete the blocking operation
timeFrame: procedure/surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Chinese PLA General Hospital
state: Haidian
Study officials:
References:
Clinical trial NCT02192723: A Randomized Double-blind Trial With 6 Antipsychotic Drugs for Schizophrenia
Official title: Effectiveness of 6 Antipsychotic Drugs in the Treatment of Acute Exacerbations of Chronic Inpatients With Schizophrenia: a Randomized Double-blind Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Schizophrenia
Lead sponsor: Beijing HuiLongGuan Hospital
Sponsor class: OTHER
First posted: 2014-07-17
Enrollment: 550
Sex: ALL
Minimum age (years): 25
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the efficacy and side effects of 6 commonly used antipsychotic drugs in the treatment of schizophrenia in a Chinese population.

Detailed description: The relative effectiveness of second-generation (atypical) antipsychotic drugs as compared with that of older agents has been incompletely addressed, though newer agents are currently used far more commonly. The investigators compared a first-generation antipsychotic, perphenazine or haloperidol, with several newer drugs in a double-blind study.

METHODS: A total of 550 patients with schizophrenia were recruited at 4 Chinese sites and randomly assigned to receive perphenazine (16 to 64 mg per day) or haloperidol(6 t0 20mg per day), olanzapine (5 to 20 mg per day), quetiapine (400 to 750 mg per day), aripiprazole (10 to 30 mg per day) or risperidone (2 to 6.0 mg per day) for up to 8 weeks.

Eligibility criteria: Inclusion Criteria:

* Patients' diagnoses is based on the results of the Structured Clinical Interview for DSM (SCID) using the criteria of the fourth edition of the Diagnostic and Statistical Manual (DSM-IV), physical exams and routine chemistry, and hematology laboratory tests. Attending-level psychiatrists will use a Chinese translation of the SCID to interview patients and their family members, who are given freedom to ask additional questions if respondents do not understand the standard probes.
* Patients must meet the following criteria: (1) diagnosis of schizophrenia; (2) duration of illness more than 2 years; (3) between 25 and 60 years of age; and (5) have NOT received antipsychotic medication for at least 1 month;(6) acute exacerbations of chronic inpatients.
* A complete medical history, electroencephalograms and electrocardiogram are obtained, and a physical examination and laboratory tests are performed at study entrance. None of the study participants have abnormal findings on these tests.

Exclusion Criteria:

-

Primary outcomes:
measure: Positive and Negative Syndrome Scale (PANSS)
timeFrame: Baseline, 8 weeks
Secondary outcomes:
measure: Clinical Global Impression (CGI)
timeFrame: Baseline, 8 weeks
Other outcomes:
measure: Udvalg for Kliniske Undersogelser (UKU) Side Effect Rating Scale
timeFrame: Baseline, 8 weeks
Locations:
city: Beijing
country: China
facility: Beijing HuiLongGuan Hospital
Study officials:
affiliation: Beijing HuiLongGuan Hospital
name: Zhi-Ren Wang, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00216723: Efficacy and Safety of Aripiprazole in Patients With Schizophrenia or Bipolar Disorder
Official title: Efficacy and Safety of Aripiprazole in Patients With Schizophrenia or Bipolar Disorder
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Schizophrenia
Bipolar Disorder
Keywords: Aripiprazole
Schizophrenia
Bipolar Disorder
Lead sponsor: Korea Otsuka Pharmaceutical Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2005-09-22
Enrollment: 3000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: * Patient with a schizophrenia or schizoaffective disorder or bipolar disorder according to DSM-IV criteria
* Age: more than 18 years of age

Brief summary: This is a multicenter,open-label,prospective study of Aripiprazole use in patients with schizophrenia and bipolar disorder.

Detailed description: This is a multicenter,open-label,prospective study of Aripiprazole use in patients with schizophrenia and bipolar disorder.

Qualified schizophrenia patients will be enrolled to an 12-week treatment phase of Aripiprazole by physician's assessment.

Qualified bipolar disorder patients will be enrolled to an 8-week treatment phase of Aripiprazole by physician's assessment.

This study will be continued for 6 years. The final report of Aripiprazole PMS will be submitted to KFDA on December 28, 2009.

Eligibility criteria: Inclusion Criteria:

* Patient with a schizophrenia or schizoaffective disorder or bipolar disorder according to DSM-IV criteria
* Age: more than 18 years of age

Exclusion Criteria:

* Unqualified patients judged by study investigator(s)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
affiliation: Korea Otsuka Pharmaceutical Co., Ltd.
name: Jieun Kwon
role: STUDY_DIRECTOR
References:
Clinical trial NCT04534023: A Clinical Study of the Efficacy of Idebenone in the Treatment of iRBD Into Synucleinopathies
Official title: A Randomized, Double-blind, Multi-center Clinical Study of the Efficacy of Idebenone in the Treatment of Primary Rapid Eye Movement Sleep Behavior Disorder Into Synucleinopathies
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Rapid Eye Movement Sleep Behavior Disorder
Synucleinopathy
Lead sponsor: Ruijin Hospital
Sponsor class: OTHER
Collaborators: name: Second Affiliated Hospital of Soochow University
name: Wuhan Union Hospital, China
First posted: 2020-09-01
Enrollment: 142
Sex: ALL
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: 142 cases of patients with iRBD will be recruited from the neurology department of Ruijin Hospital, th second Affiliated Hospital of Soochow University and wuhan Union Hospital. After the informed consent was signed, they were divided into a trial group and a control group randomly. Each group contains 71 cases. The patients in the trial group will be treated with Idebenone, while the patients in the control group was treated with placebo. Both groups of subjects will be treated for 5 years, and patients will be followed-up and evaluated in the first year, 3 years and 5 years after treatment. The observations include the MDS-UPDRS questionnaires evaluation, blood biomarker measurements and fMRI or PET-MR examination to make sure whether the patients has converted to synucleinopathies. Study hypothesis: Idebenone therapy for patients with iRBD is safe and effective in delaying disease progression into synucleinopathies.


Eligibility criteria: Inclusion Criteria:

1. Clinical diagnosed of iRBD.
2. Age between 40 and 75.
3. Be voluntarily to participate in the experiment by signing an informed consent form.

Exclusion Criteria:

1. Sleep apnea hypopnea syndrome
2. Slow movement, muscle rigidity, tremor or postural instability.
3. Neurological diseases such as cerebral hemorrhage, cerebral infarction, brain trauma, brain tumor or central nervous system infection.
4. Other sleep disorders or seizures.
5. Alcoholism or drug addiction patients.

Primary outcomes:
measure: Effective
timeFrame: 5 years
measure: Ineffective
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
state: Shanghai
Study officials:
References:
citation: Li Y, Wang C, Luo N, Chen F, Zhou L, Niu M, Kang W, Liu J. Efficacy of idebenone in the Treatment of iRBD into Synucleinopathies (EITRS): rationale, design, and methodology of a randomized, double-blind, multi-center clinical study. Front Neurol. 2022 Sep 12;13:981249. doi: 10.3389/fneur.2022.981249. eCollection 2022.
Clinical trial NCT04745923: Physical Activity Level in Patients with Chronic Kidney Disease During COVID-19 Pandemic
Official title: Fear of COVID-19 and Physical Activity Level in Patients with Chronic Kidney Disease During COVID-19 Pandemic
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
Chronic Kidney Diseases
Keywords: Fear
Quality of life
Anxiety
Depression
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2021-02-09
Enrollment: 190
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients and healthy individuals between 18-65 years old, who are diagnosed with chronic kidney disease, and whose local language is Turkish will be included in the study.

Brief summary: In the literature, there are no studies evaluating fear of COVID-19, anxiety, depression, physical activity, fear of movement and quality of life in patients with chronic kidney disease during COVID-19 pandemic. The investigators will evaluate these parameters in patients with chronic kidney disease and compare the findings of healthy individuals during COVID-19 pandemic


Eligibility criteria: Inclusion Criteria:

* Having been diagnosed with chronic kidney disease
* Being clinically stable
* Volunteering to participate in the research

Exclusion Criteria:

* Having a cognitive problem
* Not being literate

Primary outcomes:
measure: Fear of COVID-19
timeFrame: 5 minutes
measure: Physical activity
timeFrame: 5 minutes
Secondary outcomes:
measure: Qol
timeFrame: 10 minutes
measure: Anxiety and depression
timeFrame: 5 minutes
measure: Fear of movement
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University, Faculty of Physical Therapy and Rehabilitation
Study officials:
affiliation: Hacettepe University
name: Merve Firat, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: Hacettepe University
name: Naciye Vardar-Yagli, PhD
role: STUDY_DIRECTOR
affiliation: Hacettepe University
name: Tolga Yildirim, MD
role: STUDY_CHAIR
References:
Clinical trial NCT03137823: Diagnosis of GABHS Tonsillitis - Comparison Between Culture From Tonsills and Culture From the Bucal Surface
Official title: Diagnosis of GABHS Tonsillitis - Comparison Between Culture From Tonsills and Culture From the Bucal Surface
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Tonsillitis
Tonsillitis Streptococcal
Keywords: diagnosis, tonsillitis, streptococcus, GABHS
Lead sponsor: Bait Balev Hospital
Sponsor class: OTHER
First posted: 2017-05-03
Enrollment: 100
Sex: ALL
Minimum age (years): 3
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Diagnosis of Group A beta hemolytic strep tonsillitis -

* cultre of tonsills (gold standard)
* culture from bucal surface (test)

Detailed description: This study will examine 2 groups. first group of 50 children aged 3-18 years and the second group of adults aged 18-65 with a clinical diagnosis of tonsillitis and centor criteria of 2 or more (fever, exudates on tonsills, no cough, enlarged lymph nodes).

In each patient we'll take 2 cultures - the first from the tonsills and the second from the bucal surface. both of them will be sent to MEGA-LAB .

the treatment will be based only on the gold standrad culture from the tonsills.

Eligibility criteria: Inclusion Criteria:

* tonsills exudates
* Centor criteria - 2 or more

Exclusion Criteria:

* tonsillectomy

Primary outcomes:
measure: positiveGABHS culture from bucal surface in comparisson to positive culture from tonsills
timeFrame: each test will be cultures within 24-48 hours.
Secondary outcomes:
Other outcomes:
Locations:
city: Ofakim
country: Israel
facility: MACCABI
Study officials:
References:
citation: Adler L, Parizade M, Koren G, Yehoshua I. Oral cavity swabbing for diagnosis of group a Streptococcus: a prospective study. BMC Fam Pract. 2020 Mar 26;21(1):57. doi: 10.1186/s12875-020-01129-6.
Clinical trial NCT03703323: Comparison of Mortality Impact of Coagulation Rotative Thromboelastometry Analysis Versus Standard Analysis
Official title: Comparison of Mortality Impact of Coagulation Rotative Thromboelastometry Analysis Versus Standard Analysis (Prothrombin Ratio) for Patients With Digestive Hemorrage
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Hemorrhage
Lead sponsor: Centre Hospitalier Régional Metz-Thionville
Sponsor class: OTHER
First posted: 2018-10-11
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Digestive hemorrhage is a common cause of acute hemorrhage in France, and its mortality remains high despite improvement of endoscopy technique and therapeutics. Hemostasis disorders are an important issue in the patient care both in severity diagnostic and therapeutic plan.

Detailed description: Standard technique of coagulation analysis (prothrombin ratio, activated partial thromboplastin time, fibrinogen and platelet count) do not provide to guide practitioner in reanimation of hemostatic patients in particular when coagulation defect preexisting to the digestive hemorrhage.

In this respect, the main objective of this study is to evaluate the interest of rotative thromboelastometry in the care of patient with digestive hemorrhage and its mortality impact.

Eligibility criteria: Inclusion Criteria:

* Hospitalized patient in reanimation unit or continuous monitoring for digestive hemorrhage before or immediately after digestive endoscopy
* Digestive hemorrhage diagnostic: melena and/or rectal bleeding and/or hematemesis
* Affiliation to the social security
* Have signed an informed consent

Exclusion Criteria:

* Pregnant or nursing woman
* Without digestive fibroscopy
* With an anticoagulant treatment
* With a congenital coagulopathy
* Decision of therapeutic limitation or moribund patient
* With a digestive hemorrhage after an hospitalisation in reanimation unit for an other reason
* Participation in an other study in previous 30 days
* Under trusteeship, guardianship or judicial safeguards

Primary outcomes:
measure: Mortality
timeFrame: day 28
Secondary outcomes:
measure: Fresh-frozen plasma
timeFrame: day 2
measure: Length of stay
timeFrame: day 28
measure: Recurrent bleeding
timeFrame: Day 2
Other outcomes:
Locations:
city: Metz
country: France
facility: CHR Metz Thionville
Study officials:
References:
Clinical trial NCT03405623: Dynamic SAX vs Conventional LAX in Radial Artery Cannulation.
Official title: Randomized Trial of Ultrasound-guided Radial Artery Cannulation Using Dynamic Short Axis Versus Conventional Long-axis In-plane View in Cardiac Surgery Patients.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiac Surgical Procedures
Catheterization
Ultrasonography
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2018-01-23
Enrollment: 146
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: When performing vascular cannulation such as radial artery cannulation, ultrasonography (US) helps proper positioning of the tip of needle in the vascular lumen, which facilitating cannulation of the catheter and successful pressure monitoring. Conventionally, short-axis out-of-plane (SAX) and long-axis in-plane (LAX) views are commonly used method to image the target vessel during cannulation under US guidance. Dynamic needle tip positioning (DNTP) method is newly introduced by one group of investigators who conducted a related study using vascular phantom model.

In DNTP, SAX is used, and additionally, when the needle tip is imaged in the screen as an echogenic point, the practitioner (a) proximally moves the US probe a bit, and then (b) the needle is advanced until the needle tip reappears in the screen. In this manner, the practitioner repeats (a) and (b) until the needle is inserted 1 cm into the lumen of vessel, and then the catheter is inserted to finish the procedure.

DNTP has not been compared to conventional imaging methods. The aim of this trial is to see the effect of DNTP on success rate of the radial artery cannulation at the first attempt, compared to the conventional LAX.


Eligibility criteria: Inclusion Criteria:

* Elective cardiovascular surgery where RA catheterization is newly required.

Exclusion Criteria:

* skin infection or trauma
* Bilateral arteriovenous fistula for dialysis
* Severe peripheral vascular disease
* Severe arteriosclerosis or arterial atheroma
* Raynaud disease
* Shock
* Patients on ECMO or IABP support
* Morbid obesity
* Profound coagulopathy
* Negative results of modified Allen's test

Primary outcomes:
measure: Success rate of the radial artery cannulation at first attempt
timeFrame: intraoperative
Secondary outcomes:
measure: Time between skin puncture to confirmation of the arterial waveform through a pressure monitoring device.
timeFrame: During the cannulation procedure.
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References:
citation: Flumignan RL, Trevisani VF, Lopes RD, Baptista-Silva JC, Flumignan CD, Nakano LC. Ultrasound guidance for arterial (other than femoral) catheterisation in adults. Cochrane Database Syst Rev. 2021 Oct 12;10(10):CD013585. doi: 10.1002/14651858.CD013585.pub2.
Clinical trial NCT02554123: Reduction of Postoperative Pain After Milligan-Morgan Haemorrhoidectomy With Application of Vitamin E Ointment
Official title: Reduction of Postoperative Pain and Improvement of Patients´Comfort After Milligan-Morgan Haemorrhoidectomy With Application of Vitamin E Ointment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Pain
Lead sponsor: Hospital General Universitario Elche
Sponsor class: OTHER
First posted: 2015-09-18
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: A prospective ranfomized clinical study of patients undergoing Milligan Morgan´s haemorrhoidectomy at Hospital Universitario Rey Juan Carlos (Móstoles-Spain) will be performed. The patients will be randomized into 2 groups:

* Experimental group (EG): Patients undergoing Milligan Morgan´s procedure and application of Vitamin E ointment on the surgical bed.
* Control group (CG): Patients undergoing Milligan Morgan´s procedure and application of Vaseline on the surgical bed.

Postoperative pain determined by VAS at the 1st, 3rd and 7th postoperative days, and need for morphine rescue will be investigated.

Detailed description: A prospective ranfomized clinical study of patients undergoing Milligan Morgan´s haemorrhoidectomy at Hospital Universitario Rey Juan Carlos (Móstoles-Spain) will be performed. The patients will be randomized into 2 groups:

* Experimental group (EG): Patients undergoing Milligan Morgan´s procedure and application of Vitamin E ointment on the surgical bed.
* Control group (CG): Patients undergoing Milligan Morgan´s procedure and application of Vaseline on the surgical bed.

Postoperative pain determined by VAS at the 1st, 3rd and 7th postoperative days, and need for morphine rescue will be investigated by a blined epidemiology nurse.

Eligibility criteria: Inclusion Criteria:

* Patients undergoing Milligan Morgan´s haemorrhoidectomy at Hospital Universitario Rey Juan Carlos (Móstoles-Spain).
* Haemorrhoids grade III and IV
* The patients sign an Informed Consent Form agreeing their participation in the study.

Exclusion Criteria:

* Patients undergoing other surgical techniques for haemorrhoidectomy, different tan Milligan Morgan
* Haemorrhoids grade I and II
* Patients with medical or surgical pathologies that do not allow the participation in the study
* Disability to understand and accept the entry in the study

Primary outcomes:
measure: Postoperative pain
timeFrame: From the first to the 7th postoperative days
Secondary outcomes:
measure: Need for morphine rescue
timeFrame: 24 hours after surgery
Other outcomes:
Locations:
Study officials:
affiliation: Hospital Rey Juan Carlos
name: Manuel Duran, MD, PhD
role: STUDY_DIRECTOR
References: