louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03425162: Ultrasound Guided Anterior Quadratus Lumborum Block
Official title: Ultrasound Guided Anterior Quadratus Lumborum Block for Postoperative Pain After Percutaneous Nephrolithotomy: Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Ultrasound
Keywords: quadratus lumborum block
pain
ultrasound
percutaneous nephrolithotomy
Lead sponsor: Bursa Yüksek İhtisas Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2018-02-07
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: prospective,randomized,single blind
Primary purpose: TREATMENT

Brief summary: Percutaneous nephrolithotomy (PNL) is frequently used today for renal stones. percutaneous nephrolithotomy (PNL) procedure has become the treatment of choice for many patients with symptomatic renal stones . Patients undergoing PNL suffer from acute postoperative pain, despite a multimodal analgesic regime.

This is a randomised controlled trial efficacy of the anterior Quadratus Lumborum Block (QLB) in terms of analgesic efficacy in patients who undergo percutaneous nephrolithotomy.

Detailed description: Many analgesic procedures such as NSAID, opioid and regional anesthesia procedures are used as a part of multimodal analgesia for postoperative Percutaneous nephrolithotomy pain.

In this study we will use the ultrasound -guided anterior Quadratus Lumborum Block . Local anesthesic will be injected between quadratus lumborum muscle and psoas muscle with ultrasound.Analgesic effect of this block will be detected by using morphine consumption and visual analogue scale .

Eligibility criteria: Inclusion Criteria:

* Patients who were in the American Society of Anesthesiologists (ASA) I-III class and underwent elective Percutaneous nephrolithotomy

Exclusion Criteria:

* Previous history of opioid use preoperatively,

  * Allergy to local anesthetics,
  * The presence of any systemic infection,

Primary outcomes:
measure: Visual Analog Scale
timeFrame: Postoperative 24 hours
Secondary outcomes:
measure: morphine consumption
timeFrame: Postoperative 24 hours
measure: side effect profile
timeFrame: Postoperative 24 hours
measure: additional analgesic use
timeFrame: Postoperative 24 hours
Other outcomes:
Locations:
city: Bursa
country: Turkey
facility: University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital
Study officials:
affiliation: UNIVERSITY OF HEALTH SCIENCES BURSA YUKSEK IHTISAS TRAINING AND RESEARCH HOSPITAL
name: Korgün Ökmen, M.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00180362: Quick ICD Study: Is Extensive Electrophysiological Testing Before, During and After ICD-Implantation Still Necessary ?
Official title: Is Extensive Electrophysiological Testing Before, During and After ICD-Implantation Still Necessary in Patients After Survived Cardiac Arrest? A Prospective Randomised Multi-centre Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Cardiac Arrest
Lead sponsor: Boston Scientific Corporation
Sponsor class: INDUSTRY
Collaborators: name: Guidant Corporation
First posted: 2005-09-16
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the strategy of implanting an ICD with or without EPS before, during and after ICD-implantation in a randomised controlled trial, using a combined endpoint of major ICD-related adverse events as the primary outcome measure.

Detailed description: Usually, EPS before and during ICD-implantation is performed to allow risk stratification, to test serial antiarrhythmic drugs, to find suitable ablation sites in patients with hemo-dynamically stable monomorphic VTs, to exclude supraventricular tachycardias as a cause of cardiac arrest and to help programming detection rate and enhancement criteria in the ICD. However, routine EPS preceeding ICD-implantation exposes the patient to some risk and the health care system to considerable costs. So the question has been raised, whether such testing is still necessary and costseffective, if the indiaction for ICD-implantation is clear on a clinical ground.The purpose of this study is to evaluate the strategy of implanting an ICD with or without EPS before during and after ICD-implantation in a randomised controlled trial, using a combined endpoint of major ICD-related adverse events as the primary outcome measure (see details under "Endpoints"). The results will be viewed against the extra costs and patients´ quality of life both study arms.Secondary outcomes are considered as differences in decisions between the groups and difference of events in the two groups.

Eligibility criteria: Inclusion Criteria:

* structural heart disease and survived cardiac arrest or hemodynamically unstable VT (bpm \> 200/min)

Exclusion Criteria:

* conditions, which make a secondary cause for cardiac arrest probable or are not compatible with a single chamber ICD; co-morbidity, prior ICD PM, or EPS

Primary outcomes:
measure: Combined endpoint of major ICD-related adverse events as the primary outcome measure
Secondary outcomes:
measure: Costs, quality of life, differences in decision making, cardiovascular events , 18 months FU
Other outcomes:
Locations:
city: Hamburg
country: Germany
facility: Allg. Krankenhaus St. Georg
Study officials:
affiliation: Allg. Krankenhaus St. Georg
name: K. H Kuck, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00686062: Evaluation of a Decision Assisting Tool for Prenatal Testing
Official title: Adaptation and Implementation of a Prenatal Genetic Testing Decision-Assisting Tool for Clinical Use
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pregnancy
Keywords: Prenatal testing
Amniocentesis
Decision making
Down syndrome
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
Collaborators: name: Agency for Healthcare Research and Quality (AHRQ)
First posted: 2008-05-29
Enrollment: 494
Sex: FEMALE
Minimum age (years): 16
Maximum age (years): 50
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: This is a randomized study of an interactive, computerized descision-assisting tool for prenatal testing decision making (PT Tool) versus standard educational booklets distributed to all pregnant women by the State of California (control). We hypothesize that, compared to controls, women randomized to view PT Tool will have greater knowledge about prenatal testing and its potential outcomes and better risk comprehension, and that they will be more satisfied with the intervention and have lower decisional conflict.

Detailed description: We will evaluate the tool in a randomized controlled trial among 500 patients receiving prenatal care at one of the obstetrics clinics and practices affiliated with the University of California at San Francisco (UCSF), San Francisco General Hospital (SFGH), Kaiser San Francisco, or California Pacific Medical Center (CPMC). After completing a baseline questionnaire, participants will be randomized to view either a control or intervention group. Patients assigned to the control group will view the computerized version of the age-appropriate educational pamphlet concerning prenatal testing developed by the State of California. Patients assigned to the intervention group will use the computerized decision support tool/educational module which provides important background information about chromosomal abnormalities, and patient-tailored information about the advantages and limitations of diagnostic testing.

Eligibility criteria: Inclusion Criteria:

* Pregnant at less than 24 gestational weeks

Exclusion Criteria:

* Not able to speak English or Spanish

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: UCSF
state: California
Study officials:
affiliation: University of California, San Francisco
name: Miriam Kuppermann, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kuppermann M, Norton ME, Gates E, Gregorich SE, Learman LA, Nakagawa S, Feldstein VA, Lewis J, Washington AE, Nease RF Jr. Computerized prenatal genetic testing decision-assisting tool: a randomized controlled trial. Obstet Gynecol. 2009 Jan;113(1):53-63. doi: 10.1097/AOG.0b013e31818e7ec4.
Clinical trial NCT06729762: Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules
Official title: Ultrasound-guided Thermal Ablation for the Treatment of Benign Thyroid Nodules: A Multicenter Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Thyroid Nodule (Benign)
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
First posted: 2024-12-11
Enrollment: 1500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients with thyroid nodules

Brief summary: To evaluate long-term outcomes of ultrasound-guided thermal ablation for benign thyroid nodules

Detailed description: To evaluate and predict long-term clinical outcomes of ultrasound-guided thermal ablation for benign thyroid nodules by a multicenter study

Eligibility criteria: Inclusion Criteria:

1. confirmation of benign nodule status on two separate fine- needle aspiration or core-needle biopsy
2. no suspicious malignant features on ultrasound examination
3. report of cosmetic and/ or symptomatic problems or concern of nodules growing rapidly or malignant transformation
4. refusal or ineligibility for surgery
5. follow-up time ≥12 months

Exclusion Criteria:

1. follicular neoplasm or malignancy findings on biopsy
2. nodules with benign result on biopsy had suspicious of malignancy in US
3. patients with contra-lateral vocal cord paralysis
4. previous radiation to the head and neck
5. follow- up time less than 12 months

Primary outcomes:
measure: volume reduction rate
timeFrame: through study completion, an average of 6 months
Secondary outcomes:
measure: rate of complications
timeFrame: 1 week
measure: cosmetic score
timeFrame: through study completion, an average of 6 months
measure: symptom score
timeFrame: through study completion, an average of 6 months
measure: rate of nodule regrowth
timeFrame: through study completion, an average of 6 months
measure: rate of change of thyroid function
timeFrame: through study completion, an average of 6 months
measure: rate of disappearance
timeFrame: through study completion, an average of 6 months
Other outcomes:
Locations:
city: Beijing
country: China
facility: Chinese PLA General Hospital
state: Beijing
Study officials:
affiliation: Chinese PLA General Hospital
name: Yukun Luo
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05108662: Inflammatory Markers: HOLEP Versus TURP
Official title: Comparison of Surgical Stress in Patients Undergoing TURP Versus HOLEP Surgery by Measuring Perioperative Systemic Inflammatory Markers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prostate Hyperplasia
Lead sponsor: Adana City Training and Research Hospital
Sponsor class: OTHER
First posted: 2021-11-05
Enrollment: 50
Sex: MALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Aim of the study is to compare the systemic inflammatory markers and surgical stress response in patients undergoing HOLEP or TUR-P surgery.

Detailed description: Benign prostatic hyperplasia (BPH) is the most common disease in aging men worldwide, causing significant difficulties and resulting in bladder outlet obstruction. Basically, surgical techniques in patients with BPH are transurethral resection of the prostate (TURP), holmium laser enucleation of the prostate (HOLEP), and open prostoactemy surgery. There are many studies comparing the clinical outcomes of TURP and HOLEP surgery. However, to the best of our knowledge, there has not been a study comparing the effects of these two types of surgery on inflammatory markers and stress hormones.

Eligibility criteria: Inclusion Criteria:

* ASA scores I-III patients
* having benign prostatic hyperplasia
* undergoing HOLEP or TURP surgery under general anesthesia

Exclusion Criteria:

* immune system disease,
* diabetes mellitus,
* malignancy other than prostate disease,
* history of steroid use,

Primary outcomes:
measure: inflamatory markers
timeFrame: Change from baseline WBC (109 /L) at postoperative 0th and postoperative 24th hour
measure: Stress hormone levels
timeFrame: Change from baseline adrenaline (ng/L) at postoperative 0th and postoperative 24th hour
measure: inflamatory markers
timeFrame: Change from baseline CRP (mg/L) at postoperative 0th and postoperative 24th hour
measure: inflamatory markers
timeFrame: Change from baseline IL-6 (pg/ml) and TNF-alfa (pg/ml), at postoperative 0th and postoperative 24th hour
measure: inflamatory markers
timeFrame: Change from baseline CD4+/CD8+ at postoperative 0th and postoperative 24th hourL-6 (pg/ml) and TNF-alfa (pg/ml)
measure: stress hormone levels
timeFrame: Change from baseline cortisol (microg/dl) at postoperative 0th and postoperative 24th hour
Secondary outcomes:
Other outcomes:
Locations:
city: Adana
country: Turkey
facility: Adana City Training and Research Hospital
Study officials:
affiliation: Adana City Training and Research Hospital
name: Baris Arslan, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00925262: Controlled Trial of Mental Health Interventions for Torture Survivors in Kurdistan
Official title: A Controlled Trial of Mental Health Interventions for Common Mental Health Problems Experienced by Torture Survivors Living in Kurdistan, Iraq.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Depression
Keywords: mental health
randomized controlled trial
torture
Lead sponsor: Johns Hopkins Bloomberg School of Public Health
Sponsor class: OTHER
First posted: 2009-06-22
Enrollment: 530
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the relative effectiveness of three different mental health counseling interventions in the treatment of mental health problems commonly affecting torture and trauma survivors living in Kurdistan, Iraq.

Detailed description: See above

Eligibility criteria: Inclusion Criteria:

* at least 18 years old
* Kurdish
* torture survivor
* currently has significant depression symptomatology.

Exclusion Criteria:

* danger to self or others
* already receiving treatment from our treatment provider
* not mentally competent to provide informed consent.

Primary outcomes:
measure: depression symptom severity
timeFrame: 3-6 months
Secondary outcomes:
measure: ability to carry out routine tasks and activities
timeFrame: 3-6 months
measure: anxiety symptom severity
timeFrame: 3-6 months
measure: posttraumatic stress disorder symptom severity
timeFrame: 3-6 months
measure: traumatic grief symptom severity
timeFrame: 3-6 months
Other outcomes:
Locations:
city: Dohuk, Sulaimani, Erbil, rural areas
country: Iraq
facility: multiple public health clinics across Kurdistan
state: ALL
Study officials:
affiliation: Johns Hopkins Bloomberg School of Public Health
name: Paul A Bolton, MB BS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bolton P, Bass JK, Zangana GA, Kamal T, Murray SM, Kaysen D, Lejuez CW, Lindgren K, Pagoto S, Murray LK, Van Wyk SS, Ahmed AM, Amin NM, Rosenblum M. A randomized controlled trial of mental health interventions for survivors of systematic violence in Kurdistan, Northern Iraq. BMC Psychiatry. 2014 Dec 31;14:360. doi: 10.1186/s12888-014-0360-2.
Clinical trial NCT06981962: Nursing Interventions for the Prevention of Pressure Ulcer
Official title: Effectiveness of Nursing Interventions on the Prevention of Pressure Ulcers Among Immobile Stroke Patients
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Pressure Ulcer Prevention
Keywords: Immobile patient
Stroke
Pressure ulcers
Incidence
Nursing Intervention
Lead sponsor: Hawler Medical University
Sponsor class: OTHER
First posted: 2025-05-21
Enrollment: 64
Sex: ALL
Minimum age (years): 18
Maximum age (years): 73
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Intervention model description: When the program is delivered, two group of high risk patients for pressure ulcer ( Braden scale score ≤12) will be compared for the development of pressure ulcer. The group that receive the program (64 patients) will compare with group that do not receive program (64 Patients).
Primary purpose: PREVENTION

Brief summary: this study is aimed to assess the effectiveness of nursing interventions on the prevention of pressure ulcers among immobile stroke patients

Detailed description: Research question: Question 1: What is the effect of nursing educational interventional program on the prevention of pressure ulcers among immobile stroke patients.

The interventional program will be provided for the patients over a period of two days in the hospital, then the pressure ulcer prevention program will demonstrated by the researcher. The education and demonstration will consist of proper positioning, frequent change of patients' posture to limit or decrease pressure over the skin, skincare, such as maintaining adequate hydration, keep skin clean, prevent excessive dryness of skin, prevent message over bony prominence, and control moisture.

A manual in the form of booklet will be given to the patients and their family caregiver.

Eligibility criteria: Inclusion Criteria:

1. Both gender
2. Patients' age ≥ 18 years old.
3. Patients who

   1. are at highly risk for pressure ulcer development.
   2. Braden scale score ≤ 12
   3. Are able to communicate clearly
   4. Provide written informed consent
   5. Do not participate in another study and do not receive any information regarding pressure ulcer prevention.

Exclusion Criteria:

1. Patients who have different types of mental problems
2. Braden scale score \> 12
3. Have history of previous pressure ulcer and are unable to respond to verbal commands.
4. Patients who work as a health care provider.
5. Patients with different stages of pressure ulcer.

   -

Primary outcomes:
measure: Change the incidence of pressure ulcer
timeFrame: 3 weeks follow up after patients discharge
Secondary outcomes:
Other outcomes:
Locations:
city: Erbil
country: Iraq
facility: Hawler Medical University
state: Kurdistan
Study officials:
References:
Clinical trial NCT01394562: Effect of Ferric Carboxymaltose on Exercise Capacity in Patients With Iron Deficiency and Chronic Heart Failure
Official title: Multicentre, Prospective, Randomised, 2-arm Study to Assess the Impact of Ferric Carboxymaltose on Exercise Capacity in Chronic Heart Failure Patients With Iron Deficiency
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Iron Deficiency
Chronic Heart Failure
Lead sponsor: Vifor Pharma
Sponsor class: INDUSTRY
First posted: 2011-07-14
Enrollment: 174
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to confirm that treatment with IV ferric carboxymaltose improves exercise capacity, physical functioning and quality of life in patients with iron deficiency and chronic heart failure.


Eligibility criteria: Inclusion Criteria:

* Iron deficient subjects with stable chronic heart failure (CHF) (NYHA II-III) on optimal background therapy for CHF
* Reduced exercise capacity
* Reduced left ventricular ejection fraction
* At least 18 years of age and with written informed consent prior to any study specific procedures

Exclusion Criteria:

* Erythropoietin stimulating agent (ESA) use, IV iron therapy, and/or blood transfusion in previous 6 weeks prior to randomisation
* Exercise training program(s) in the 3 months prior to screening or planned in the next 6 months
* Chronic liver disease and/or elevated liver enzymes
* Vitamin B12 and/or serum folate deficiency
* Subject is not using adequate contraceptive precautions during the study
* No other significant cardiac or general disorder that would compromise participation in the study

Primary outcomes:
measure: Change in Peak VO2 (mL/kg/min) from baseline to Week 24
timeFrame: Week 24
Secondary outcomes:
Other outcomes:
Locations:
city: Groningen
country: Netherlands
facility: University Medical Center Groningen
Study officials:
affiliation: University Medical Center Groningen
name: Dirk van Veldhuisen, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: van Veldhuisen DJ, Ponikowski P, van der Meer P, Metra M, Bohm M, Doletsky A, Voors AA, Macdougall IC, Anker SD, Roubert B, Zakin L, Cohen-Solal A; EFFECT-HF Investigators. Effect of Ferric Carboxymaltose on Exercise Capacity in Patients With Chronic Heart Failure and Iron Deficiency. Circulation. 2017 Oct 10;136(15):1374-1383. doi: 10.1161/CIRCULATIONAHA.117.027497. Epub 2017 Jul 12.