louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00451750: Cortisol in the Treatment of Phobias
Official title: The Efficacy of Cortisol in Combination With Behavioral Therapy in the Treatment of Phobias
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Phobia
Keywords: phobia
cortisol
memory
treatment
Lead sponsor: University of Zurich
Sponsor class: OTHER
Collaborators: name: University Hospital, Basel, Switzerland
First posted: 2007-03-23
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this prospective, double-blind, placebo-controlled, randomized study is to investigate if glucocorticoid treatment, in combination with exposure therapy, helps to reduce phobic fear in patients with phobia.


Eligibility criteria: Inclusion Criteria:

- Female and male patients with a specific phobia (fear of heights) according to DSM-IV criteria.

Exclusion Criteria:

* Severe acute or chronic somatic diseases
* Psychiatric disorder other than specific phobia
* Topic glucocorticoid therapy (for large skin parts)
* Inhaled glucocorticoids
* Psychotropic medication
* Pregnancy

Primary outcomes:
measure: visual analog scales for fear and acrophobia questionnaires
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Basel
country: Switzerland
facility: University of Basel
Study officials:
affiliation: University of Zurich
name: Dominique JF de Quervain, MD, Prof.
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Basel
name: Frank Wilhelm, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Soravia LM, Heinrichs M, Aerni A, Maroni C, Schelling G, Ehlert U, Roozendaal B, de Quervain DJ. Glucocorticoids reduce phobic fear in humans. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5585-90. doi: 10.1073/pnas.0509184103. Epub 2006 Mar 27.
Clinical trial NCT03223350: Topical Capsaicin for Cyclical Vomiting
Official title: Topical Capsaicin Cream for Treatment of Suspected Cyclical Vomiting Syndromes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Cyclical Vomiting
Lead sponsor: Henry Ford Health System
Sponsor class: OTHER
First posted: 2017-07-21
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a phase 2 randomized controlled trial testing the effect of topical capsaicin for the relieve of nausea and vomiting.


Eligibility criteria: Inclusion Criteria:

* suspected cyclical vomiting syndrome / cannabinoid hyperemesis
* active severe nausea or vomiting in the emergency department

Exclusion Criteria:

* pregnant women, children \< 18 years, no prior history of similar symptoms, suspected surgical or infectious cause of symptoms, suspected hepatitis or pancreatitis, allergy to capsaicin or hot peppers, chronic use of prescription antiemetic in prior 24 hours, abdominal pain alone (without nausea or vomiting)

Primary outcomes:
measure: Nausea Visual Analog Scale
timeFrame: 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
Study officials:
affiliation: Henry Ford Hospital
name: Joseph Miller, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04892355: Postoperative Pain After İntracanal Procedures
Official title: Postoperative Pain After İntracanal Procedures Based On Different İrrigation Activation Tecniques: A Randomized, Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Endodontically Treated Teeth
Keywords: EDDY
EndoActivatör
Xp-endo Finisher
Postoperative pain
Lead sponsor: Afyonkarahisar Health Sciences University
Sponsor class: OTHER
First posted: 2021-05-19
Enrollment: 140
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 4-group clinical trial
Primary purpose: TREATMENT

Brief summary: Aim: The aim of this study is to investigate the effects of different irrigation activation systems on pain after endodontic treatment in molar teeth with irreversible pulpitis.Post-operative pain values of the participants will be recorded and evaluated with the VAS scale.

Postoperative pain values of the techniques will be compared with statistical evaluation.

Detailed description: Aim: The aim of this study is to investigate the effects of different irrigation activation systems on pain after endodontic treatment in molar teeth with irreversible pulpitis.Materials and Methods: The study will be carried out on 140 patients with molar teeth diagnosed with irreversible pulpitis. After the root canal preparation is completed, the patients will be divided into 4 groups according to the irrigation activation system; Conventional syringe irrigation (CSI), EDDY, EndoActivator (EA) and Xp-endo Finisher (XPF). After the irrigation process is completed, the root canals will be filled using gutta-percha and canal sealer and the treatment will be completed in one session. Pain values at 6, 24, 48, 72 hours and 7 days after treatment will be evaluated at a 0.05% significance level using the Kruskal-Wallis test.

Eligibility criteria: Inclusion Criteria:

* Healthy patients ranging between 18 and 60 years in age
* Patients that experienced moderate-to-severe pain represented on a visual analogue scale (VAS)
* Maxillar and Mandibular molar teeth were diagnosed with symptomatic irreversible pulpitis

Exclusion Criteria:

* Any systemic disease and pregnancy in the patient
* Having used analgesic-anti-inflammatory in the last 12 hours and cortisone for the last 6 months
* The patient has bruxism
* Teeth with severe damage
* Teeth with calcified canals
* Teeth with pain to percussion
* Teeth with periapical radiolucency
* Teeth with root resorption
* Teeth with an immature / open apex
* Teeth with previous RCT

Primary outcomes:
measure: Postoperative Pain After İntracanal Procedures Based On Different İrrigation Activation Tecniques: A Randomized, Clinical Trial
timeFrame: one week(7 days)
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Afyonkarahisar Health Sciences University
name: yahya güven
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06845176: Combining Motor Imagery and Tendon Vibration on the Effectiveness of Motor Imagery
Official title: Comparison of Three Modalities of Combining Motor Imagery and Tendon Vibration on the Effectiveness of Motor Imagery
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Healthy Volunteer
Keywords: Kinesthetic motor imagery
Tendon vibration
Corticospinal excitability
Neuroplasticity
Electroencephalography
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
Collaborators: name: Jean Monnet University
First posted: 2025-02-25
Enrollment: 33
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Kinesthetic motor imagery (kMI) involves imagining the sensations of movement, activating brain regions similar to actual movement execution. It is widely used to maintain or restore motor functions, particularly in rehabilitation. Tendon vibration (TV), which stimulates proprioceptive receptors can also enhance corticospinal excitability and promote neuroplasticity. This project investigates the coupling of kMI and TV through three modalities: simultaneous application, TV application between kMI trials, or pre-application of TV to precondition the nervous system before kMI trials. The effectiveness and quality of kMI will be assessed by corticospinal excitability measurements using transcranial magnetic stimulation and EEG measures. Conducting this study in healthy participants will inform the development of optimized clinical interventions for immobilized or mobility-reduced patients.


Eligibility criteria: Inclusion Criteria:

* Men or women aged 18 to 50 years.
* Affiliated with or beneficiaries of a social security system.
* Provided written informed consent freely after being informed of the study's purpose, procedures, and potential risks.

Exclusion Criteria:

* History of pathology or surgery affecting upper limb motor function within 6 months prior to the study.
* Chronic neurological, motor, or psychiatric disorders.
* Use of neuroactive substances likely to alter corticospinal excitability (e.g., hypnotics, antiepileptics, psychotropics, muscle relaxants) during the study period.
* Contraindications to transcranial magnetic stimulation
* Simultaneous participation in another interventional study or participation in such a study within 30 days prior to this study.

Primary outcomes:
measure: Optimization of kMI
timeFrame: 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Saint-etienne
country: France
facility: IRMIS-Hôpital Nord
Study officials:
affiliation: Centre Hospitalier Universiatire de SAINT-ETIENNE
name: Léonard FEASSON, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00690976: Proyecto SOL: A Risk Reduction Intervention for Hispanic Men Who Have Sex With Men (MSM)
Official title: Proyecto SOL: A Risk Reduction Intervention for Hispanic MSM
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: HIV Infections
Keywords: HIV Seronegativity
HIV risk behavior
Unprotected sex
men who have sex with men
gay
Latino
Unsafe Sex
Lead sponsor: Centers for Disease Control and Prevention
Sponsor class: FED
Collaborators: name: Nova Southeastern University
name: University of Miami
name: DePaul University
First posted: 2008-06-05
Enrollment: 220
Sex: MALE
Minimum age (years): 18
Maximum age (years): 49
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this project is to determine the acceptability, feasibility, and the preliminary efficacy of an HIV prevention behavioral intervention (Proyecto SOL) to reduce behaviors associated with HIV acquisition among Hispanic men who have sex with men (HMSM). The primary goal of the intervention is to motivate and assist participants in forming and carrying out a "Safer Options for Life" plan, thereby reducing their risk of HIV acquisition or transmission.


Eligibility criteria: Inclusion Criteria:

* self-identify as Hispanic or Latino;
* be between 18 and 49 years of age;
* be a resident of South Florida (Miami-Dade, Broward or Palm Beach counties) and not planning to move out of the area for the next 9 months;
* self-identify as male;
* have had at least one episode of unprotected anal sex with a man in the preceding 3 months;
* have had 2 or more male sex partners in the preceding 3 months;
* be HIV negative or of unknown serostatus;
* speak English and/or Spanish;
* provide informed consent.

Exclusion Criteria:

* have previously participated in any Phase of this study;
* self-identify as transgender;
* not being a resident of South Florida.

Primary outcomes:
measure: Unprotected sex
timeFrame: three months
Secondary outcomes:
Other outcomes:
Locations:
city: Fort Lauderdale
country: United States
facility: NOVA Southeastern University
state: Florida
Study officials:
affiliation: Nova Southeastern University
name: Isa Fernandez, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03758976: Sweden Cancerome Analysis Network - Breast Recurrence (SCAN-B-rec)
Official title: SCAN-B-rec: Infrastructure, Technology Platform and Clinical Research Development to Profile and Monitor Metastatic Breast Cancer
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Metastatic Breast Cancer
Keywords: Metastatic breast cancer
Molecular profiling
Circulating tumor DNA
Circulating tumor cells
Lead sponsor: Lund University Hospital
Sponsor class: OTHER
First posted: 2018-11-29
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed with metastatic, inoperable breast cancer.

Brief summary: Prospective multicenter observational study to assess molecular drivers of metastatic breast cancer and disease evolution upon therapeutic pressure.

The main aim is to develop and validate prognostic, predictive and pathogenic markers in clinically well-characterized population-based material of breast cancer tumors and the corresponding normal tissue.These data will be used to characterize recurrent breast cancer on a molecular level, study tumor evolution, develop biomarkers of response/resistance to targeted therapy in the metastatic setting, enroll patients on targeted treatment clinical studies and to elucidate mechanisms of resistance to therapy.


Eligibility criteria: Inclusion Criteria:

1. Patients with pathologically confirmed advanced breast cancer (ABC), including locally advanced inoperable disease and stage IV disease.
2. Age \> 18 years.
3. Performance status according to Eastern Cooperative Oncology Group (ECOG) ≤ 2.
4. ABC must be radiologically or clinically assessable, by means of at least one of the following techniques: clinical examination, computerized tomography (CT-scan), magnetic resonance imaging (MRI), bone scintigraphy or positron emission tomography (PET).
5. Patients must have a radiological evaluation done maximum 6 weeks prior to inclusion.
6. Signed informed consent according to ICH/GCP, and national/local regulations.

Exclusion Criteria:

Untreated psychiatric disorders that will impair the patient's ability to comply with study treatment or protocol.

Primary outcomes:
measure: Survival
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Lund
country: Sweden
facility: Lund University Hospital
city: Lund
country: Sweden
facility: Lund University Hospital
Study officials:
References:
Clinical trial NCT02486276: The Effect of Sumatriptan and Placebo on Cilostazol Induced Headache
Official title: The Effect of Sumatriptan and Placebo on Cilostazol Induced Headache. Development of a Pragmatic Migraine Model
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Migraine
Lead sponsor: Danish Headache Center
Sponsor class: OTHER
First posted: 2015-07-01
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a phosphodiesterase inhibitor (cilostazol). If the headache responds to sumatriptan, the model can be used to test new drug candidates.

Detailed description: There remains a great need for more effective anti-migraine drugs with fewer side effects. Human experimental models are valuable in early phase development of new anti-migraine drugs but useful models have not yet been developed. The investigators' group has shown that Cilostazol, a phosphodiesterase inhibitor induce headache/migraine in both healthy volunteers and in patients with migraine without aura (MO). To validate this model, the headache must respond to specific migraine treatment with sumatriptan.

Hypothesis: Cilostazol induces a migraine-like headache in both healthy subjects and in MO-patients and induced headache responds to a specific anti migraine drug; sumatriptan.

Aim: Developing a pragmatic and valid model for the testing of new anti-migraine drugs.

Eligibility criteria: Inclusion criteria:

Healthy:

* Healthy subjects of both sexes
* Age 18-70 years
* Weight 50-90 kg.
* Females were requested to use effective contraception.

Migraine patients:

* Migraine patients who meet IHS criteria for migraine with or without aura of both sexes
* 18-70 years
* 45-95 kg.

Exclusion Criteria:

Healthy:

* Any type of headache (except episodic tension-type headache \< 1 day per week)
* Serious somatic or psychiatric disease
* Pregnancy
* Intake of daily medication (except oral contraceptives).

Migraine patients:

* Any other type of headache then migraine without aura (except episodic tension-type headache \< 1 day per week)
* Serious somatic or psychiatric disease
* Pregnancy
* Intake of daily medication (except oral contraceptives)

Primary outcomes:
measure: Difference in median headache score 2 hours after sumatriptan/placebo
timeFrame: 2 hours
Secondary outcomes:
measure: Area under the headache score curve
timeFrame: 12 hours
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Emma Katrine Hansen
state: Glostrup
Study officials:
affiliation: Danish Headache Center
name: Emma Katrine Hansen, Doctor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Falkenberg K, Dunga BOA, Guo S, Ashina M, Olesen J. Cilostazol induced migraine does not respond to sumatriptan in a double blind trial. J Headache Pain. 2018 Feb 2;19(1):11. doi: 10.1186/s10194-018-0841-7.
Clinical trial NCT04096976: Epidemiology and Determinants of Short-Term Outcome in Critically Ill Patients With Near-Hanging Injury
Official title: Outcome After Near-Hanging Injury
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Near Hanging
Lead sponsor: Versailles Hospital
Sponsor class: OTHER
First posted: 2019-09-20
Enrollment: 900
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All eligible cases extracted from the participation ICUs hospital registries were included in the present study if they were older than 18 years, with in- or out-of-hospital near-hanging self-arm, and if they required ICU management.

Brief summary: Near-Hanging is a catastrophic event that has been merely studied in the literature. We aimed to report the outcomes, and early predictors of hospital survivors in critically ill patients with near-hanging.

Patients admitted to 31 university or university-affiliated participating ICUs in France and Belgium between 1992 and 2014 were studied retrospectively. Hospital survival was the main judgment criterion.


Eligibility criteria: Inclusion Criteria:

* any of the following code corresponding in the International Statistical Classification of Diseases and Related Health Problems, 10th Revision: Intentional self-harm by hanging, strangulation and suffocation (X70). Local investigators reviewed the medical records of the patients thus identified to select adults admitted to the ICU after successfully resuscitated near-hanging injury.
* older than 18 years
* requiring ICU management

Exclusion Criteria:

-

Primary outcomes:
measure: Hospital survival
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: de Charentenay L, Schnell G, Pichon N, Schenck M, Cronier P, Perbet S, Lascarrou JB, Rossignol T, Lesieur O, Argaud L, Colin G, Cholley B, Quenot JP, Merdji H, Silva S, Piagnerelli M, Chelly J, Salvetti M, Couraud S, Deye N, Danguy des Deserts M, Paul M, Thiery G, Simon M, Martin C, Vincent F, Das V, Jacq G, Jacobs F, Soummer A, Mayaux J, Beuret P, Ouchenir A, Durant C, Darmon M, Azoulay E, Sauneuf B, Daubin C, Mongardon N, Biard L, Cariou A, Geeraerts T, Legriel S; Antigone Investigators. Outcomes in 886 Critically Ill Patients After Near-Hanging Injury. Chest. 2020 Dec;158(6):2404-2413. doi: 10.1016/j.chest.2020.07.064. Epub 2020 Aug 3.
Clinical trial NCT06914076: Evaluating The Effectiveness Of Structured Psychosocial Counseling On Mental Health And FI Individuals With Low Vision
Official title: Evaluating The Effectiveness Of Structured Psychosocial Counseling On Mental Health And Functional Independence In Individuals With Low Vision
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Low Vision
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2025-04-06
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Vision impairments affect 2.2 billion people worldwide, including 36 million who are blind and 217 million with moderate-to-severe visual impairment. In the US, age-related vision loss is a leading cause of disability among older adults.

Detailed description: With increasing longevity, global blindness rates are expected to triple, and moderate-to-severe vision impairment rates to double in 30 years. The study aims to assess the effects of structured psychosocial counseling on mental health (depression, anxiety) and functional independence in individuals with low vision. Additionally, it seeks to evaluate the overall impact on quality of life (QoL) following the counseling intervention. A randomized controlled trial will be conducted at Superior University Lahore.

Eligibility criteria: Inclusion Criteria:

* Individuals aged 18 to 80 years.
* Both male and female
* Individuals diagnosed with low vision, defined as a visual acuity of less than 6/18 but equal to or better than 3/60 in the better eye with best correction.
* Individuals having visual acuity 6/60, Counting fingers or light perception.
* Individuals experiencing symptoms of depression or anxiety as assessed through a validated screening tool.
* Individuals reporting reduced functional independence in daily activities due to low vision.

Exclusion Criteria:

* Unable to provide informed consent.
* Diagnosed with severe psychiatric disorders such as schizophrenia, bipolar disorder, or severe post-traumatic stress disorder.
* Existing involvement in similar counseling programs.
* Presence of medical conditions or disabilities.
* Pregnant individuals if pregnancy-related complications or responsibilities could interfere with participation in the intervention.

Primary outcomes:
measure: DASS 21
timeFrame: 12 Months
measure: LVQoL Questionare
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Gujrānwāla
country: Pakistan
facility: Dial hospital, Qadirabad road Ali pur chattah
state: Punjab
Study officials:
References: