Clinical trial NCT06197555: Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes
Official title: Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dentine Hypersensitivity
Keywords: Dentin Hypersensitivity
Toothpaste
Fluoride
Arginine
Nano-Hydroxyapatite
Lead sponsor: Altinbas University
Sponsor class: OTHER
First posted: 2024-01-09
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Dentin hypersensitivity is a common problem in society. Untreated hypersensitivity affects the patient's quality of life, complicates plaque control and increases the risk of caries and periodontal disease. This study aimed to evaluate the clinical efficacy of desensitizing toothpastes containing sodium fluoride, stannous fluoride, nano-hydroxyapatite, 8% arginine and calcium carbonate.

Fourty eight patients with at least two teeth with positive responses to air and mechanical stimulus were included in the study and were divided into four groups. Sodium fluoride (Colgate®, Cavity Protection) in group A, stannous fluoride (Oral B® Gum Calm \& Sensitivity) in group B, nano-hydroxyapatite (ApaCare®) in group C and 8% arginine and calcium carbonate combination in group D (Colgate® Sensitive Pro- ReliefTM) were used by the patients continuously for 16 weeks. Dentin hypersensitivity, by using VAS and Shiff scores and periodontal parameters were evaluated at baseline, 2nd week, 4th week and last 16th week.


Eligibility criteria: Inclusion Criteria:

* Dentin hypersensitivity complaints
* Systemically healthy
* Not during pregnancy \& lactation
* No sensitivity treatment in the last 6 months
* Forty-eight patients with positive response to VAS and Schiff tests were included.

Exclusion Criteria:

People who have;

* Any systemic disease
* Take regular medication for any other reason
* Undergone periodontal surgery within the last 6 months,
* History of allergy to toothpaste materials,
* Active caries, restoration and/or bridge on the sensitive tooth,
* Orthodontic appliances,

Primary outcomes:
measure: Hypersensitivity Reduction
timeFrame: Baseline, 2nd week, 4th week, 16th week
measure: Hypersensitivity Reduction
timeFrame: Baseline, 2nd week, 4th week, 16th week
Secondary outcomes:
measure: Clinical Periodontal Measurements
timeFrame: Baseline, 16th week
measure: Clinical Periodontal Measurements
timeFrame: Baseline, 16th week
measure: Clinical Periodontal Measurements
timeFrame: Baseline, 16th week
measure: Clinical Periodontal Measurements
timeFrame: Baseline, 16th week
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Altinbas University
Study officials:
affiliation: Altinbas University
name: İlknur ÖZENCİ
role: STUDY_CHAIR
affiliation: Altinbas University
name: Şebnem DİRİKAN İPÇİ
role: STUDY_DIRECTOR
affiliation: Altinbas University
name: Gökser ÇAKAR
role: STUDY_DIRECTOR
affiliation: Altinbas University
name: Sevdenur GÜNENÇ
role: PRINCIPAL_INVESTIGATOR
References: