Clinical trial NCT04576338: "Neighborhood Disadvantage, Sleep and Vascular Health"
Official title: "Neighborhood Disadvantage, Sleep, and Vascular Health: Racial Disparities in Cardiometabolic Health and Blood Pressure"
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Blood Pressure
Sleep
Racism
Stiffness, Arterial
Endothelial Dysfunction
Keywords: blood pressure
sleep
endothelial dysfunction
social determinants of health
arterial stiffness
Lead sponsor: Auburn University
Sponsor class: OTHER
First posted: 2020-10-06
Enrollment: 55
Sex: ALL
Minimum age (years): 19
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The cohort consists of Black and White college students at a university in a southeastern state in America. The cohort will be, by design, generally healthy, young adults free from known cardiometabolic disease,

Brief summary: The purpose of the study is to find out the effects of neighborhood disadvantage and sleep disparities contribute to racial disparities in cardiometabolic health and blood pressure in young adults.

Detailed description: There are well-documented disparities between Black and white Americans in the incidence of cardiovascular disease, the leading cause of death in America. There are also disparities between Black and White Americans in the incidence of hypertension (high blood pressure; BP), which is the leading risk factor for cardiovascular disease. Our long-term goal is to determine effective strategies to prevent racial disparities in cardiovascular health. In this proposal, the investigators will focus on determining societal and biological mediators of racial disparities in young adults that can be targeted in future interventions. Poor sleep is associated with adverse cardiovascular events and hypertension. Moreover, recent meta-analyses demonstrate that Black adults have consistently poorer sleep health than White adults, including receiving fewer total sleep minutes and having worse overall sleep quality. Neighborhood socioeconomic environments influence health behaviors through both material resources (e.g., access to healthful foods and safe public space) and social norms (e.g. exercise, diet, smoking). A well-documented history of discriminatory policies and practices has resulted in black individuals living in more disadvantaged physical and social environments than whites. As such, they experience greater adverse exposures (e.g., racism, violence and stress), which negatively impact sleep, resulting in dysregulation of cardiometabolic health. Therefore, the investigators seek to determine the role of neighborhood disadvantage and sleep in contributing to racial disparities in cardiovascular health.

Eligibility criteria: Inclusion Criteria:

-

Exclusion Criteria:

* Systolic blood pressure greater than 150 mmHg
* Diastolic blood pressure greater than 90 mmHg
* Body mass index above 35 kg/m\^2
* History of cardiovascular disease
* Recent (one year) history of cancer
* History of metabolic disease (e.g. type 2 diabetes)

Primary outcomes:
measure: Flow-mediated dilation (FMD)
timeFrame: Baseline racial comparison
measure: Pulse wave velocity (arterial stiffness)
timeFrame: Baseline racial comparison
measure: Pulse wave analysis (arterial stiffness)
timeFrame: Baseline racial comparison
measure: 24-hour ambulatory blood pressure
timeFrame: Baseline racial comparison
measure: Blood pressure reactivity
timeFrame: Baseline racial comparison
measure: Objective sleep duration and quality
timeFrame: Baseline racial comparison
measure: Subjective sleep quality
timeFrame: Baseline racial comparison
Secondary outcomes:
measure: Circulating reactive oxygen species
timeFrame: Baseline racial comparison
measure: Blood biomarkers of nitric oxide bioavailability
timeFrame: Baseline racial comparison
measure: Physical activity
timeFrame: Baseline racial comparison
measure: Mental health - social anxiety
timeFrame: Baseline racial comparison
measure: Mental health - depression
timeFrame: Baseline racial comparison
measure: Neighborhood disadvantage
timeFrame: Baseline racial comparison
measure: Habitual dietary intake
timeFrame: Baseline racial comparison
Other outcomes:
measure: 24-hour urine electrolytes
timeFrame: Baseline racial comparison
Locations:
city: Auburn
country: United States
facility: Kinesiology Building
state: Alabama
Study officials:
affiliation: Auburn University
name: Austin T Robinson, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jeong S, Linder BA, Barnett AM, Tharpe MA, Hutchison ZJ, Culver MN, Sanchez SO, Nichols OI, Grosicki GJ, Bunsawat K, Nasci VL, Gohar EY, Fuller-Rowell TE, Robinson AT. Interplay of race and neighborhood deprivation on resting and ambulatory blood pressure in young adults. Am J Physiol Heart Circ Physiol. 2024 Sep 1;327(3):H601-H613. doi: 10.1152/ajpheart.00726.2023. Epub 2024 Jul 12.
citation: Robinson AT, Linder BA, Barnett AM, Jeong S, Sanchez SO, Nichols OI, McIntosh MC, Hutchison ZJ, Tharpe MA, Watso JC, Gutierrez OM, Fuller-Rowell TE. Cross-sectional analysis of racial differences in hydration and neighborhood deprivation in young adults. Am J Clin Nutr. 2023 Oct;118(4):822-833. doi: 10.1016/j.ajcnut.2023.08.005. Epub 2023 Aug 22.