Clinical trial NCT03778476: Isometric Exercise and Endogenous Pain Inhibition
Official title: Isometric Exercise and Endogenous Pain Modulation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Fibromyalgia
Keywords: Exercise
pain sensitivity
fibromyalgia
Lead sponsor: Marquette University
Sponsor class: OTHER
First posted: 2018-12-19
Enrollment: 43
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: The two groups will participate in two sessions receiving intervention or no intervention in a randomized manner.
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to identify the acute effects of isometric exercise on the inhibition of pain in individuals with fibromyalgia.

Detailed description: Fibromyalgia syndrome (FMS) is a chronic pain condition that is characterized by widespread pain which affects 5-8% of the general population. Past research has shown that people with FMS demonstrate enhanced pain facilitation and reduced pain inhibition in the central nervous system. Incorporating a biopsychosocial model of pain may help develop strategies to prevent the functional decline and alleviate the suffering that occurs in this population. Exercise is a mainstay of pain rehabilitation with multiple health benefits, one of which is decreasing pain; a phenomenon known as exercise induced hypoalgesia (EIH). Emerging evidence has shown that exercise decreases pain facilitation in healthy adults and in some individuals with FMS. However, it's unclear whether exercise improves pain inhibition in individuals with FMS. The purpose of this study is to investigate endogenous pain inhibition, measured by conditioned pain modulation (CPM), following isometric exercise of the quadriceps muscle in individuals with FMS. In addition, factors that might affect this response such as physical activity, body composition, and psychosocial issues will be examined. Understanding how exercise impacts pain and the contributing factors will help guide the prescription of exercise to optimize pain rehabilitation.

Eligibility criteria: Inclusion Criteria:

* Men and women aged 18-75 diagnosed with fibromyalgia or healthy controls will be included in the study.

Exclusion Criteria:

* cardiovascular disease, cancer, pregnancy, arthritis, diabetes, claustrophobia, Reynaud's disease, osteoporosis, neuropathy.

Primary outcomes:
measure: Conditioned Pain Modulation
timeFrame: baseline, immediately after exercise or quiet rest
Secondary outcomes:
measure: Vibration Perception Threshold
timeFrame: baseline, immediately after exercise or quiet rest
Other outcomes:
measure: Numerical Pain Rating Scale (NPRS)
timeFrame: baseline, during exercise, and immediately after exercise or quiet rest
Locations:
city: Milwaukee
country: United States
facility: Marquette University
state: Wisconsin
Study officials:
affiliation: Marquette University
name: Marie Hoeger Bement, PT, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Marquette University
name: Ali Alsouhibani, PT, MS
role: STUDY_DIRECTOR
References: