louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00002060: A Multi-Center Randomized Double-Blind Placebo-Controlled Study To Investigate the Effect of Isoprinosine in Patients With AIDS Related Complex (ARC)
Official title: A Multi-Center Randomized Double-Blind Placebo-Controlled Study To Investigate the Effect of Isoprinosine in Patients With AIDS Related Complex (ARC)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: HIV Infections
Keywords: AIDS-Related Opportunistic Infections
Inosine Pranobex
Homosexuality
Acquired Immunodeficiency Syndrome
AIDS-Related Complex
Lead sponsor: NIH AIDS Clinical Trials Information Service
Sponsor class: INDUSTRY
First posted: 2001-08-31
Sex: MALE
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: The objective is to determine the effect of Isoprinosine (inosine pranobex) in homosexual male patients with AIDS related complex (ARC) in delaying the onset of AIDS. Secondly, to determine the effect of Isoprinosine in decreasing the severity and/or incidence of lesser opportunistic infections and/or other conditions associated with ARC.


Eligibility criteria: Exclusion Criteria

Concurrent Medication:

Excluded:

* Cardiac glycosides.

Patients with the following are excluded:

* AIDS.
* Presenting with chronic candida infection-colo/rectal, oral/pharyngeal, cutaneous (finger/toenails) - for = or \> 3 months who have not responded to therapy.
* Critical illness.
* Hemophilia.

Prior Medication:

Excluded within 1 month of study entry:

* Steroids.
* Cytotoxic immunosuppressive agents.
* Radiotherapy and/or systemic antiviral medication.
* Immunomodulators (including Isoprinosine).

Prior Treatment:

Excluded within 1 month of study entry:

* Radiotherapy.

History of gout, uric acid urolithiasis, uric acid nephrolithiasis, or renal dysfunction.

* Lymphoid malignancy.

Homosexual male patients with AIDS related complex (ARC).

Current IV drug abuse.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Laguna Hills
country: United States
facility: Newport Pharmaceuticals International Inc
state: California
Study officials:
References:
Clinical trial NCT01142960: Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population
Official title: Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lens Opacity
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
Collaborators: name: The Hong Kong Jockey Club Charities Trust
First posted: 2010-06-14
Enrollment: 238
Sex: ALL
Minimum age (years): 60
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: With the rapid growing aging population, age-related eye diseases including cataract are becoming more prevalent. The demand for cataract surgery and post-surgical care posed enormous financial burdens to the government.

Lycium barbarum contains lutein and zeaxanthin which can filter the phototoxic blue light and neutralize the reactive oxygen species, thus provide a protective effect against cataract formation.

This study aims to determine the effects of Lycium barbarum Supplements on the progression of senile cataract in Hong Kong Chinese elderly.

Detailed description: Please note that a manuscript for this study is being prepared. Detailed description will be provided after we come up with the final draft.

Eligibility criteria: Inclusion Criteria:

* Unlikely to have cataract surgery within 3 years
* Presence of mild to moderate cataract in one or both eyes, graded by Lens Opacities Classification System III (LOCSIII).
* logMAR acuity equivalent to Snellen acuity of 20/63 or better
* no previous history and clinical signs of glaucoma by determining intraocular pressure using applanation Tonometry (no more than 22mmHg)
* no ocular anomalies: amblyopia, binocular anomalies, ocular trauma
* no history of eye surgery, laser treatment, iritis, retinal crystalline deposits, macular degeneration, or optic nerve diseases
* no extended use of systemic or ocular corticosteroid drugs
* no concurrent participation of other systemic or ocular drug intervention study

Exclusion Criteria:

* diabetes mellitus
* renal failure
* fat malabsorption syndrome
* intestinal surgery history
* chronic diarrhea
* alcoholism
* use of anticoagulants
* regular use of nutritional supplements such as multi-vitamin, mineral and other antioxidant supplements (including Omega-3)

Primary outcomes:
measure: Lens Opacity Classification System III (LOCSIII)
timeFrame: 3 years
Secondary outcomes:
measure: Visual Acuity
timeFrame: 3 years
Other outcomes:
Locations:
city: Hung Hom
country: Hong Kong
facility: The Hong Kong Polytechnic University
state: Kowloon
Study officials:
affiliation: The Hong Kong Polytechnic University
name: Chi-wai Do, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: The Hong Kong Polytechnic University
name: Chea-su Kee, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03905460: Point-of-care Ultrasound in Prehospital Dyspnea
Official title: Point-of-care Ultrasound in Prehospital Dyspnea: Game-changer or Gaming-gadgets?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dyspnea
Lead sponsor: University of Aarhus
Sponsor class: OTHER
Collaborators: name: Randers Regional Hospital
First posted: 2019-04-05
Enrollment: 219
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All citizens who have contacted the Acute Medical Coordination center in the Central Denmark Region for emergency medical treatment.

Brief summary: Point-of-care ultrasound in patients with dyspnoea has been shown to alter patient treatment and the time to correct treatment when performed in emergency departments. In Denmark, physician-staffed ambulances are sent to citizens with severe ABCD symptoms including dyspnoea. Hence, there is a potential for correct diagnostics and appropriate treatment already in the citizens' own home or en route to the hospital. This study aims to evaluate the clinical performance of prehospital point-of-care ultrasound in patients with dyspnoea.


Eligibility criteria: Inclusion Criteria:

* age \>/= 18 years
* dyspnea as a dominating complaint At least one of
* respiratory frequency \>25/minute
* oxygen saturation \< 95%
* oxygen therapy initiated

Exclusion Criteria:

* trama patients
* prior enrollment

Primary outcomes:
measure: Sensitivity for diagnosing heart failure
timeFrame: From initial citizen contact to end of ultrasound examination within 15 minutes
Secondary outcomes:
measure: Sensitivity, clinical exam
timeFrame: From initial citizen contact and within a time-span of 15 minutes
measure: Sensitivity, Ultrasound examination
timeFrame: From initial citizen contact and within a time-span of 15 minutes
measure: Treatment changes in medicine caused by ultrasound examination
timeFrame: From initial citizen contact and within a time-span of 15 minutes
measure: Treatment changes in ventilation caused by ultrasound examination
timeFrame: From initial citizen contact and within a time-span of 15 minutes
measure: Triage changes caused by ultrasound examination
timeFrame: From initial citizen contact and within a time-span of 60 minutes
Other outcomes:
Locations:
city: Aarhus
country: Denmark
facility: Præhospitalet
Study officials:
affiliation: Prehospital of Central Denmark Region
name: Morten Bøtker, MD, Phd
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03515460: Acute Effects of Oral Carbohydrate and Fat Loads on Systemic Microvascular Endothelial Function in Healthy Individuals.
Official title: Acute Effects of Standardized Oral Carbohydrate and Fat Loads, and the Association of Carbohydrate and Fat Loads, on Systemic Microvascular Endothelial Function in Healthy Individuals.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Metabolic Syndrome
Keywords: vascular endothelial function
systemic microvascular reactivity
dysglycemia
dyslipidemia
Lead sponsor: National Institute of Cardiology, Laranjeiras, Brazil
Sponsor class: OTHER_GOV
First posted: 2018-05-03
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The present study was designed to evaluate vascular endothelial dysfunction resulting from the oral ingestion of high loads of sugar and fat meals in healthy individuals.

Detailed description: The chronic and elevated consumption of fat and carbohydrates is associated with the initiation and the progression of cardiovascular and metabolic diseases, including diabetes, obesity and metabolic syndrome. In general, chronic diseases are related to underlying modifiable cardiovascular risk factors, including high blood pressure, high plasma lipids and glucose, physical inactivity, overweight and obesity, as well as smoking habits.

Vascular endothelial dysfunction is one of the earliest findings in the pathophysiology of atherosclerosis and also an important predictor of cardiovascular events. Moreover, it has already been demonstrated that acute oral ingestion of high loads of sugar and fat meals induces transient vascular endothelial dysfunction, which over time could lead to cardiovascular disease.

Thus, the present study aimed at investigating the individual contributions of sugar and fat ingestion on systemic microvascular endothelial reactivity.

Eligibility criteria: Inclusion Criteria:

* healthy individuals presenting body mass index between 18.5 e 24.9 kg/m2

Exclusion Criteria:

* dysglycemia and dyslipidemia
* overweight and obesity

Primary outcomes:
measure: endothelial-dependent microvascular function
timeFrame: one day
Secondary outcomes:
Other outcomes:
Locations:
city: Rio de Janeiro
country: Brazil
facility: National Institute of Cardiology, Ministry of Health, Brazil
Study officials:
affiliation: National Institute of Cardiology
name: EDUARDO TIBIRICA, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04500860: Low Dose Tadalafil for Treatment of Female OAB Syndrome: Short Term Follow up.
Official title: Low Dose Tadalafil 5mg for Treatment of Female Overactive Bladder Syndrome :6 Months Follow up
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Female Patients With Overactive Bladder Syndrome or Female Patients With Urgency or Urgency Urinary Incontinence
Lead sponsor: Kasr El Aini Hospital
Sponsor class: OTHER
First posted: 2020-08-05
Enrollment: 90
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Evaluation of use of low dose tadalafil 5 mg daily for treatment of female OAB syndrome

Detailed description: 90 female patients with overactive bladder syndrome divided into 3 groups group A subjected to daily low dose tadalafil 5 mg ,group B subjected to tolterodine and group C to placebo. They are evaluated as using OAB symptoms score for 6 months follow up

Eligibility criteria: Inclusion Criteria:

* any female with overactive bladder syndrome, urgency with or without urgency urinary incontinence

Exclusion Criteria:

* Active Urinary tract infection
* neurologic abnormality
* Pure Stress urinary incontinence

Primary outcomes:
measure: Efficacy of daily low dose tadalafil 5mg in treatment of female overactive bladder syndrome: 6 months follow up
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Samer Morsy
Study officials:
References:
Clinical trial NCT01763060: Long Term Follow up of Patients Who Were Treated With Extracorporeal Membrane Oxygenation for Pandemic Influenza A/H1N1 Induced Severe Respiratory Failure
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Long Term Outcome
Keywords: ards
ecmo
h1n1
pandemics
Lead sponsor: Karolinska University Hospital
Sponsor class: OTHER
Collaborators: name: Karolinska Institutet
name: Uppsala University Hospital
First posted: 2013-01-08
Enrollment: 7
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients who survived ECMO treatment due to infection with Influenza A/H1N1 2009 up to 3 years after discharge from hospital

Brief summary: Patients treated with Extracorporeal Membrane Oxygenation (ecmo) for severe respiratory or circulatory failure show severe long term disability due to impaired lung -, cerebral-, cognitive function and impaired quality of life. This study investigates the long term outcome of all patients who are still alive three years after ECMO treatment for severe respiratory failure during the H1N1 2009 pandemic at the Karolinska University Hospital.


Eligibility criteria: Inclusion Criteria:

* Survivors of ECMO treatment for influenza a/h1n1 pneumonia during 2009/2010 pandemics at the ECMO Center Karolinska

Exclusion Criteria:

* None

Primary outcomes:
measure: Lung function
timeFrame: 3 years after ecmo treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Karolinska University Hospital
Study officials:
References:
citation: Holzgraefe B, Andersson C, Kalzen H, von Bahr V, Mosskin M, Larsson EM, Palmer K, Frenckner B, Larsson A. Does permissive hypoxaemia during extracorporeal membrane oxygenation cause long-term neurological impairment?: A study in patients with H1N1-induced severe respiratory failure. Eur J Anaesthesiol. 2017 Feb;34(2):98-103. doi: 10.1097/EJA.0000000000000544.
Clinical trial NCT04451460: Effect of Hyponatremia in Small Cell Lung Cancer
Official title: Frequency and Effect on the Prognosis of Hyponatremia During the diagnosıs in Small Cell Lung Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Small Cell Lung Cancer
Keywords: Small cell lung cancer
hyponatremia
prognosis
treatment
biochemistry
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2020-06-30
Enrollment: 466
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed with SCLC between January 2012 and January 2017 in our hospital were retrospectively screened

Brief summary: In this retrospective study, the investigators determined the frequency of hyponatremia in small cell lung cancer and the prognosis. 126 (27%) of 466 patients were hyponatremic. Hyponatremia could not be corrected in 50.8% (n=64) of hyponatremic patients. Survival was found to be better in the group of whom hyponatremia was corrected.


Eligibility criteria: Inclusion Criteria:

Patients diagnosed with SCLC between January 2012 and January 2017 in our hospital were retrospectively screened

Exclusion Criteria:

Over 18 age If data doesn't exist

Primary outcomes:
measure: Mortality
timeFrame: Through study completion, an average of 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02198560: RS-3000 Lite Agreement Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: Normal (Eyes without pathologies)
Lead sponsor: Nidek Co. LTD.
Sponsor class: INDUSTRY
First posted: 2014-07-23
Enrollment: 30
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Normal (Eyes without pathology)

Brief summary: The primary objectives of the study are to assess the agreement between the two different scan mode of the RS-3000 Lite.


Eligibility criteria: Inclusion Criteria:

* Subjects who do not have pathology in both eyes

Exclusion Criteria:

Subjects who have any of the following conditions:

* Diabetes mellitus (DM) and/or diabetic retinopathy
* Uncontrolled Hypertension (HT)
* Cerebral infarction, cerebral hemorrhage, cranial nerve neoplasm and other central nervous system diseases affecting vision
* Cardiac, hepatic, renal and hematologic diseases
* A current condition requiring systemic administration of steroid
* A history of, or currently receiving, anticancer therapy
* Epileptic seizures which are optically induced
* Dementia

Note: Additional criteria may apply

Primary outcomes:
measure: Retinal thickness and Optic Disc Analysis
timeFrame: 3 hours
Secondary outcomes:
measure: Number of participants with adverse events
timeFrame: 1day
Other outcomes:
Locations:
city: Okazaki
country: Japan
facility: Nabeta Ganaka Iin
state: Aichi
Study officials:
References:
Clinical trial NCT03260660: Comparison of MR Elastography Methods Without and With Compressed Sensing
Official title: Comparison of MR Elastography Methods Without and With Compressed Sensing
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Liver Diseases
Lead sponsor: Children's Hospital Medical Center, Cincinnati
Sponsor class: OTHER
First posted: 2017-08-24
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy Volunteers

Brief summary: In this research study, the investigators will compare the liver stiffness results obtained from the current Magnetic Resonance Imaging (MRI) method to liver stiffness results obtained from a method that uses faster imaging techniques.

Detailed description: MR elastography is increasingly used to assess liver stiffness in pediatric and adult patients with chronic liver diseases. While numerous tissue abnormalities can affect liver stiffness, liver stiffness measured by MR elastography is most often used to predict and quantify liver fibrosis. Conventional MR elastography techniques require multiple breath-holds that are 12-20 seconds in length. In the pediatric population, reliable breath-holding \>10 seconds can be challenging. Recently, compressed sensing has become available as a method for accelerating image data acquisition, and thus shortening breath-holds.

Eligibility criteria: Inclusion Criteria:

* Adult volunteers ≥18 years of age
* Ability to tolerate 30 minutes in an MRI scanner.
* Nothing to eat or drink for 4 hours prior to the MRI scan

Exclusion Criteria:

* No contraindication to MR imaging (e.g., implanted non-MRI compatible device)
* Known or suspected pregnancy. Female subjects of child bearing potential will undergo a urine pregnancy test prior to imaging.

Primary outcomes:
measure: Standard Magnetic Resonance Elastography versus Elastography with Compressed Sensing (x1.5)
timeFrame: 30 minutes
measure: Standard Magnetic Resonance Elastography versus Elastography with Compressed Sensing (x2)
timeFrame: 30 minutes
measure: Standard Magnetic Resonance Elastography versus Elastography with Compressed Sensing (x3)
timeFrame: 30 minutes
Secondary outcomes:
measure: Standard Magnetic Resonance Elastography versus respiratory triggered Magnetic Resonance Elastography.
timeFrame: 30 minutes
measure: Standard Magnetic Resonance Elastography versus navigated triggered Magnetic Resonance Elastography.
timeFrame: 30 minutes
Other outcomes:
Locations:
city: Cincinnati
country: United States
facility: Cincinnati Children's Hospital Medical Center
state: Ohio
Study officials:
affiliation: Children's Hospital Medical Center, Cincinnati
name: Jonathan Dillman, MD,MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01041560: Muscle Tone Changes in Acute Stroke According to Brain Injury
Official title: Muscle Tone Changes in Acute Stroke According to Brain Injury in Relation to Changes in Functioning
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Stroke
Keywords: Stroke
Tone
Strength
Lead sponsor: Jyväskylä Central Hospital
Sponsor class: OTHER
Collaborators: name: Eurostars
First posted: 2009-12-31
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Stroke patients in Middle-Finland Central hospital

Brief summary: The purpose of the study is to examine connections between muscle tones, strength and function after stroke.

Detailed description: Measurements are intended to repeat every two days in acute phase to discover possible changes in tone and strength in arm and leg muscles.

Eligibility criteria: Inclusion Criteria:

* unilateral decline in the arm or leg muscle strength

Exclusion Criteria:

* unwilling to take part on the trial
* not conscious
* no differences between muscle strength on the right and left side

Primary outcomes:
measure: Muscle tone
timeFrame: Immediately after stroke, during the first week in hospital every other day, and then once a week before discharging from hospital
Secondary outcomes:
measure: Muscle strength
timeFrame: Immediately after stroke, during the first week in hospital every other day, and then once a week before discharging from hospital
Other outcomes:
Locations:
city: Jyväskylä
country: Finland
facility: Central Finland Health Care District
Study officials:
affiliation: Senior physician
name: Jari Ylinen, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT04710160: Clinical and Radiographic Evaluation in Pulpotomy of Primary Molars Using Protooth Vs. MTA
Official title: Clinical and Radiographic Evaluation in Pulpotomy of Primary Molars Using Novel Fast-setting Calcium Silicate Cement (Protooth) Versus Mineral Trioxide Aggregate (MTA): A Pilot Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Clinical Evaluation Including Pain and Swelling
Keywords: Pulpotomy , Primary molars , Protooth , MTA
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2021-01-14
Enrollment: 40
Sex: ALL
Minimum age (years): 4
Maximum age (years): 8
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to evaluate the clinical and radiographic success in pulpotomy using novel fast-setting calcium silicate cement (Protooth) versus MTA in exposed primary molars.


Eligibility criteria: Inclusion Criteria:

* Complete physical and mental health, with no confounding history of systemic disease and/or use of special local or systemic drugs
* No allergic reactions recorded in patient history
* Having primary molar teeth in one jaw, having deep caries and vital pulp.
* No history of spontaneous pain, pathologic mobility, draining sinus tract, redness or swelling of vestibule
* Normal gingival and periodontal condition, with no sensitivity to vestibular palpation, and no pain on percussion test

  * Radiographic criteria:
* No sign of radiolucency in periapical or furcation area
* No widening of PDL space or loss of lamina dura continuity
* No evidence of internal/external pathologic root resorption

Exclusion Criteria:

* Lack of informed consent by the child patient's parent
* Lack of informed consent by the child patient's parent
* Unable to attend follow-up visits.
* Refusal of participation.

Primary outcomes:
measure: Clinical evaluation including postoperative pain , pain on percussion or palpation will be measured using VAS
timeFrame: 12 months
Secondary outcomes:
measure: Radiographic evaluation following the Pulpotomy treatment will be measured
timeFrame: 12 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentsitry , Cairo University
state: El Manial
Study officials:
References: