Clinical trial NCT05224076: Home Air Quality Impact for Adults with Asthma
Official title: The Changing COVID-19 Landscape: a Feasibility Study to Capture Momentary Residential Environmental Exposures and Asthma Symptoms in Adults
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Asthma
Environmental Exposure
Home Environment Related Disease
Keywords: volatile organic compounds
particulate matter
home air quality
asthma control
ecological momentary assessment
home air quality monitoring
smartphone technology
home spirometry
Lead sponsor: University of Kansas Medical Center
Sponsor class: OTHER
Collaborators: name: National Institute of Environmental Health Sciences (NIEHS)
First posted: 2022-02-04
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adults with asthma living in the US

Brief summary: The purposes of this study are to determine the practicality of using home indoor air quality monitoring and a smartphone app to identify home air quality changes and how these changes affect adults with asthma.

Detailed description: The aims of this feasibility study are: 1) determine the feasibility and usability of: (a) ecological momentary assessment (EMA) to assess self-report residential environmental exposures and asthma symptoms, (b) home monitoring of objective environmental exposures (total volatile organic compounds \[VOCs\], particulates \[PM2.5\]), and lung function (home spirometry); 2a) assess the frequency and degree of residential environmental exposures (e.g., disinfectants/cleaners, second-hand smoke) via (a) self-reported data, and (b) home monitoring objective measures, 2b) assess the level of asthma control as indicated by self-reported asthma symptoms and lung function; and 3) explore associations of self-reported and objective measures of residential environmental exposures with self-reported and objective measures of asthma control. Participants will receive an indoor air quality monitor and a home spirometer to measure VOCs, PM2.5, and forced expiratory volume percent predicted, respectively. EMA will be collected using a personal smartphone and EMA software platform. Participants' will be sent scheduled and random EMA notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation strategies. After the 14-day data collection period, participants will respond to survey items related acceptability, appropriateness, and feasibility.

Eligibility criteria: Inclusion Criteria:

* Adults who previously participated in the online Global Covid-19 and Asthma Study, indicated willingness to be contacted for future research, and reported high use of disinfectant/cleaning products since COVID-19 (≥5 per week).
* Current Asthma Control Test (ACT) ≤19
* Own a smartphone
* Have a Wi-Fi/wireless internet connection in their home.

Exclusion Criteria:

* Non-US residents
* Non-English speaking

Primary outcomes:
measure: Home environmental exposure to Volatile organic compounds
timeFrame: Measured continuously for 14 days
measure: Home environmental exposure to particulate matter (PM)
timeFrame: Measured continuously for 14 days
measure: Asthma control
timeFrame: Assessed daily for 14 days
Secondary outcomes:
measure: Usability of study tools
timeFrame: 14 days
measure: Compliance with Ecological Momentary Assessment (EMA) prompts
timeFrame: Compliance over 4-hour periods for 14 days
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: Barbara J Polivka
state: Kansas
Study officials:
affiliation: Select
name: Barbara Polivka, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Eldeirawi K, Huntington-Moskos L, Nyenhuis SM, Polivka B. Increased disinfectant use among adults with asthma in the era of COVID-19. J Allergy Clin Immunol Pract. 2021 Mar;9(3):1378-1380.e2. doi: 10.1016/j.jaip.2020.12.038. Epub 2020 Dec 29. No abstract available.
citation: Matulonga B, Rava M, Siroux V, Bernard A, Dumas O, Pin I, Zock JP, Nadif R, Leynaert B, Le Moual N. Women using bleach for home cleaning are at increased risk of non-allergic asthma. Respir Med. 2016 Aug;117:264-71. doi: 10.1016/j.rmed.2016.06.019. Epub 2016 Jun 25.
citation: Le Moual N, Varraso R, Siroux V, Dumas O, Nadif R, Pin I, Zock JP, Kauffmann F; Epidemiological Study on the Genetics and Environment of Asthma. Domestic use of cleaning sprays and asthma activity in females. Eur Respir J. 2012 Dec;40(6):1381-9. doi: 10.1183/09031936.00197611. Epub 2012 Apr 10.
citation: Zock JP, Plana E, Jarvis D, Anto JM, Kromhout H, Kennedy SM, Kunzli N, Villani S, Olivieri M, Toren K, Radon K, Sunyer J, Dahlman-Hoglund A, Norback D, Kogevinas M. The use of household cleaning sprays and adult asthma: an international longitudinal study. Am J Respir Crit Care Med. 2007 Oct 15;176(8):735-41. doi: 10.1164/rccm.200612-1793OC. Epub 2007 Jun 21.
citation: Gharpure R, Hunter CM, Schnall AH, Barrett CE, Kirby AE, Kunz J, Berling K, Mercante JW, Murphy JL, Garcia-Williams AG. Knowledge and Practices Regarding Safe Household Cleaning and Disinfection for COVID-19 Prevention - United States, May 2020. MMWR Morb Mortal Wkly Rep. 2020 Jun 12;69(23):705-709. doi: 10.15585/mmwr.mm6923e2.
citation: Nyenhuis S, Cramer E, Grande M, Huntington-Moskos L, Krueger K, Bimbi O, Polivka B, Eldeirawi K. Utilizing Real-time Technology to Assess the Impact of Home Environmental Exposures on Asthma Symptoms: Protocol for an Observational Pilot Study. JMIR Res Protoc. 2022 Aug 2;11(8):e39887. doi: 10.2196/39887.