louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02432508: Efficacy of Laser Acupuncture on Pruritus in Patients With Chronic Kidney Disease Undergoing Hemodialysis
Official title: Efficacy of Laser Acupuncture on Pruritus in Patients With Chronic Kidney Disease Undergoing Hemodialysis: A Multiple Centers, Randomized, Assessor- and Participant-blind, Controlled, Cross-over Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pruritus
Kidney Failure, Chronic
Keywords: acupuncture
laser
uremic pruritus
randomized clinical trial
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2015-05-04
Enrollment: 200
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Uremic pruritus is a clinically significant symptom which imposes heavy impact on the quality of life of patients with chronic kidney disease undergoing hemodialysis. In order to investigate the clinical efficacy and mechanism, the investigators designed a multiple centers, randomized, assessor- and participant-blind, controlled, cross-over clinical trial. This trial will be conducted at Taichung branch, Feng-yuan branch and the Eastern branch of CMUH.

Detailed description: We plan to enroll 200 volunteer patients with uremic pruritus. After the waiting period (as the waiting list group), you will be randomized to laser acupuncture and sham laser acupuncture group. Each group will include 100 patients and given intervention according to their hemodialysis frequency, i.e., BIW or TIW. The intervention will then be crossed over to the other one after 4 week of wash-our period. Outcome measurement includes questionnaires, biochemistry analysis, instrumental analysis and medication score.

Eligibility criteria: Inclusion Criteria:

* Age\>20y/o, ESRD patient, pruritus symptoms persist longer than 4 weeks

Exclusion Criteria:

* immunosupression agents use, undergo chemotherapy
* drug abuser
* pregnancy women
* patient with psychiological disorder
* arrhythemia, pacemaker device use
* local skin infection over laser acupuncture site
* patient allergy to laser acupuncture treament

Primary outcomes:
measure: Pruritus Visual Analogue Scale
timeFrame: 20 weeks
Secondary outcomes:
measure: Short-Form-36 Health Survey (SF-36)
timeFrame: 20 weeks
measure: Dermatology Life Quality Index (DLQI)
timeFrame: 20 weeks
measure: The 5-D itch scale
timeFrame: 20 weeks
measure: The Pittsburgh Sleep Quality Index; PSQI
timeFrame: 20 weeks
measure: Beck Depression Inventory, BDI
timeFrame: 20 weeks
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: China Medical University Hospital
Study officials:
affiliation: School of Medicine, China Medical University
name: Chang Chiz-Tzung, Ph.D.
role: STUDY_CHAIR
References:
citation: Hercz D, Jiang SH, Webster AC. Interventions for itch in people with advanced chronic kidney disease. Cochrane Database Syst Rev. 2020 Dec 7;12(12):CD011393. doi: 10.1002/14651858.CD011393.pub2.
Clinical trial NCT03558308: CBCR for Executive Functions in Patients With ABI in the Chronic Phase
Official title: The Effects of Computer Based Cognitive Rehabilitation on Executive Functions in Patients With Acquired Brain Injury in the Chronic Phase: A Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acquired Brain Injury
Cognitive Symptom
Executive Dysfunction
Lead sponsor: Bispebjerg Hospital
Sponsor class: OTHER
Collaborators: name: University of Copenhagen
First posted: 2018-06-15
Enrollment: 72
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study examines the effects of computerbased cognitive rehabilitation on executive functions in the chronic phase after acquired brain injury

Detailed description: This study examines the effects of computerbased cognitive rehabilitation on executive functions in the chronic phase after acquired brain injury using two clinically developed programmes and one sham-intervention. Furthermore, the study consists of Groups that receives the computerized training both with and witouth support from a professional.

Eligibility criteria: Inclusion Criteria:

* Persons who are able to give an informed consent both verbally and in writing
* Persons in the chronic phase after stroke or traumatic brain injury (more than one year post onset)
* Persons who score less than the 30. Percentile in one or more of the primary outcome measures outlined above.

Exclusion Criteria:

* Persons with neurodegenerative diseases
* Persons with diseases which can influence executive functions such as ADHD
* Persons who are motorically or cognitively unable to use a tablet and complete the CBCR-training

Primary outcomes:
measure: PASAT
timeFrame: 3 seconds
measure: Trail making test A+B
timeFrame: 5 minutes
Secondary outcomes:
measure: SDMT
timeFrame: 90 seconds
measure: Word fluency test
timeFrame: 1 min
measure: Digit span (WAIS-IV)
timeFrame: 5 minutes
measure: Spatial span (WMS-III)
timeFrame: 5 minutes
measure: Stroop colour and word test
timeFrame: 3 minutes
measure: BNI-FS
timeFrame: 10 minutes
measure: Quality of Life after Brain Injury (QOLIBRI)
timeFrame: 10 minutes
measure: Wordlist, Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Amager
country: Denmark
facility: Center for Hjerneskade
state: København
Study officials:
affiliation: University of Copenhagen
name: Jesper Mogensen, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01562808: Change in Brain Metabolism and Cognitive Function by Aripiprazole
Official title: The Relationship Between D2 Occupancy and Change in Frontal Metabolism and Working Memory Induced by Aripiprazole
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Antipsychotics
Cognition
Brain Metabolism
Dopamine Receptor Occupancy
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2012-03-26
Enrollment: 15
Sex: MALE
Minimum age (years): 19
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task.

The investigators explored the relationship between changes in brain metabolism and working memory performance.


Eligibility criteria: Inclusion Criteria:

* healthy volunteers
* right-handed

Exclusion Criteria:

* any significant abnormality on routine lab
* any psychiatric disease

Primary outcomes:
measure: Reaction time of correct response in N-back task
timeFrame: 48 hrs after the administration of aripiprazole
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Jun Soo Kwon, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01711008: The Effect of Breakfast Size Prior to Morning Exercise on Cognition, Mood and Appetite in Habitually Active Women
Official title: The Effect of Breakfast Size Prior to Morning Exercise on Cognition, Mood and Appetite Later in the Day in Habitually Active Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alteration of Cognitive Function
Keywords: Breakfast size
Exercise
Cognitive performance
Mood
Appetite
Active women
Lead sponsor: Northumbria University
Sponsor class: OTHER
First posted: 2012-10-19
Enrollment: 24
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: Both regular exercise and breakfast consumption have well known health benefits. Consuming breakfast prior to morning exercise may influence appetite, mood and cognitive function later in the day. The purpose of this study is to test whether the amount of food consumed at breakfast prior to exercise influences these parameters in active women.


Eligibility criteria: Inclusion Criteria:

* Must be habitually active (exercising for least 30 minutes, 3 times per week for at least the previous 6 months)
* Must have a normal exercise routine includes a minimum of 1 morning exercise session (which takes place between 6am-11am) each week
* Must run on a regular basis (at least once per week) and be able to run at a moderate pace for 30 minutes non-stop on a treadmill
* Must consume breakfast on most days of the week, usually consume breakfast before undertaking a morning exercise session and be comfortable consuming a bowl of cereal 45mins before running

Exclusion Criteria:

* English not first language
* Smoking
* Previous or current eating disorders, metabolic disorders, gastric problems or any contraindications of exercise.
* Pregnancy
* The habitual use of some prescription or over the counter medications (excluding contraception) or herbal/dietary supplements (please ask the researcher)
* A history of or current learning difficulties, ADHD or dyslexia
* Daily use of an inhaler to control asthma
* Allergies or intolerances to any of the foods provided in the study (Special K cereal, semi-skimmed milk, pasta, tomato sauce, cheese, olive oil, rice, custard)

Primary outcomes:
measure: Cognitive function change from baseline scores
timeFrame: Assessed hourly until 4.5 hours and at 6.5 and 10.5 hours
Secondary outcomes:
measure: Mood change from baseline scores
timeFrame: Assessed hourly until 4.5 hours and at 6.5 and 10.5 hours
Other outcomes:
measure: Appetite change from baseline scores
timeFrame: Assessed hourly until 4.5 hours and at 6.5 and 10.5 hours
Locations:
city: Newcastle upon Tyne
country: United Kingdom
facility: Brain, Performance and Nutrition Research Centre, Northumbria Univerity
state: Tyne and Wear
Study officials:
affiliation: Northumbria University
name: Rachel Veasey
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02775708: Development of Applications of the ® PillCam Endoscopy System and Evaluation of Their Performance
Official title: Development of Applications of the ® PillCam Endoscopy System and Evaluation of Their Performance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Any Gastric Condition Which Requires Capsule Endoscopy
Lead sponsor: Medtronic - MITG
Sponsor class: INDUSTRY
First posted: 2016-05-18
Enrollment: 53
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The purpose of this study is to support development of PillCam Endoscopy System applications.


Eligibility criteria: Inclusion Criteria:

* Subject's from 18 years of age.
* Subject is indicated for Capsule Endoscopy procedure.
* Subject agrees to sign the Informed Consent Form.

Exclusion Criteria:

* Female subject is pregnant.
* Subject is known or is suspected to suffer from intestinal obstruction (symptoms such as severe abdominal pain with accompanying nausea or vomiting).
* Subject has a pacemaker or other implanted electro-medical device.
* Subject has any condition, which precludes compliance with study and/or device instructions, such as swallowing problems.
* Subject suffers from life threatening conditions.
* Subject is currently participating in another clinical study that may directly or indirectly affect the results of this study

Primary outcomes:
measure: Number of gaps in the RAPID video will be assessed
timeFrame: capsule endoscopy procedure day
Secondary outcomes:
Other outcomes:
Locations:
city: Furth
country: Germany
facility: Klinikum Furth
city: Pamplona
country: Spain
facility: Hospital De Navarra
state: Navarra
Study officials:
References:
Clinical trial NCT02725008: Trial of One Versus Two Doses of Dexamethasone for Pediatric Asthma Exacerbation
Official title: A Randomized Double Blinded Placebo Controlled Trial of One Versus Two Doses of Oral Dexamethasone for the Treatment of Acute Asthma Exacerbation in the Pediatric Emergency Department (ED)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Asthma
Keywords: Asthma
Pediatric
Emergency Department
Dexamethasone
Steroid
Lead sponsor: New York Presbyterian Brooklyn Methodist Hospital
Sponsor class: OTHER
First posted: 2016-03-31
Enrollment: 99
Sex: ALL
Minimum age (years): 18
Maximum age (years): 20
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparing one versus two doses of oral dexamethasone for the treatment of asthma in the pediatric emergency department.

Detailed description: A randomized double blinded placebo controlled trial comparing one dose of dexamethasone administered in the Emergency Department with two doses, the first given in the emergency department and the second 24 hours after the index ED visit.

Eligibility criteria: Inclusion Criteria:

* History of asthma defined as at least two (2) prior episodes of respiratory illness characterized by wheezing treated with inhaled beta agonists

Exclusion Criteria:

* pregnancy
* severe chronic cardiac, respiratory, neurological or neuromuscular disease
* complete resolution of symptoms after one treatment of beta agonists
* severe asthma symptoms as defined by a Pulmonary Index Score of 12 or greater

Primary outcomes:
measure: Treatment Failure
timeFrame: 5 days
Secondary outcomes:
measure: Change in Symptom Severity From Day 1 to Day 5
timeFrame: 5 days
Other outcomes:
Locations:
city: Brooklyn
country: United States
facility: New York Methodist Hospital
state: New York
Study officials:
affiliation: New York Presbyterian Brooklyn Methodist Hospital
name: Christopher Kelly, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00907023: Transition From Hospital to Home in Solid Organ Transplant (SOT)
Official title: The Transition From Hospital to Home in Parents of Solid Organ Transplant Recipients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Solid Organ Transplant
Keywords: solid organ transplant
hospital discharge
Lead sponsor: Medical College of Wisconsin
Sponsor class: OTHER
First posted: 2009-05-22
Enrollment: 37
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Three Pediatric Transplant Hospitals

Brief summary: The aim of this study is to determine the influences of discharge teaching and care coordination on how ready a parent is to take their child home from the hospital after a solid organ (kidney, heart and liver) transplant. This study will also look into how the parent handles coping, utilization of healthcare resources, and parent adjustment 3 weeks after discharge from the hospital.

Detailed description: Parents of children that have received a heart, kidney or liver transplant will be asked to participate in this protocol. Involvement in this study involves completion of questionnaires prior to the child being discharged from the hospital. Three weeks after discharge, there will also be a follow-up phone call to complete more questionnaires.

Readiness for hospital discharge is a under-investigated topic in pediatric solid organ transplant patients, despite the increasing number of pediatric patients undergoing transplant surgery. Results from this study will be used to develop an intervention program to promote readiness for hospital discharge in parents of children who receive a solid organ transplant.

Eligibility criteria: Inclusion Criteria:

* parents of children who have undergo a heart, kidney, or liver transplant
* English Speaking
* Parents are 18 years of age or older

Exclusion Criteria:

* parents with significant cognitive or communication impairment that would not allow them to complete the questionnaires
* parent whose child is receiving their 2nd or 3rd organ transplant

Primary outcomes:
measure: Determine the influences of care coordination and discharge teaching on readiness for discharge in solid organ transplant recipients
timeFrame: 2 years
Secondary outcomes:
measure: Determine the relationship of parent readiness for hospital discharge with coping, utilization of healthcare resources, medication adherence, and parent adjustment following hospital discharge
timeFrame: 2 years
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Children's Memorial Hospital
state: Illinois
city: Charlotte
country: United States
facility: Levine Children's Hospital
state: North Carolina
city: Milwaukee
country: United States
facility: Children's Hospital of Wisconsin
state: Wisconsin
Study officials:
affiliation: Medical College of Wisconsin
name: Stacee Lerret, CPNP
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05967923: Effectiveness of Shock Wave Therapy Versus Low Level Lazer Therapy in Diabetic Frozen Shoulder Patients.
Official title: Effectiveness of Shock Wave Therapy Versus Low Level Lazer Therapy in Diabetic
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Diabetes Complications
Keywords: Diabetes
Frozen shoulder
Lead sponsor: South Valley University
Sponsor class: OTHER
First posted: 2023-08-01
Enrollment: 40
Sex: ALL
Minimum age (years): 45
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Group (a) Group (b) Group (c)
Primary purpose: TREATMENT

Brief summary: Patients will be divided randomly into 3 groups.

Detailed description: Patients will be allocated from out patient clinics of Qena university hospitals Then they will be randomly assigned to three groups, every one will contain 30 patients of both gender, with age range between 45 and 60 years old

Eligibility criteria: Inclusion Criteria:

* patients with diabetes mellitus.
* patients with frozen shoulder due to diabetes mellitus.
* patients age ranged between 45 and 60 years old.
* cooperative patients.

Exclusion Criteria:

* patients with un-controlled hypertension.
* patients sensetive to shock wave or lazer irradiation.
* Patients with infectious skin diseases.
* un-cooperative patients.

Primary outcomes:
measure: Shoulder joint Pain
timeFrame: 4 weeks
measure: Range of motion of the shoulder
timeFrame: 4 weeks
Secondary outcomes:
measure: Shoulder and hand disability
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Shymaa yussuf abo zaid
Study officials:
References:
Clinical trial NCT05791123: Alveolar Ridge Augmentation Following Tooth Extraction Using Bovine Xenograft With Platelet Rich Fibrin Membrane
Official title: Alveolar Ridge Augmentation Following Tooth Extraction Using Bovine Xenograft With Platelet Rich Fibrin Membrane
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bone Regeneration
Lead sponsor: Future University in Egypt
Sponsor class: OTHER
First posted: 2023-03-30
Enrollment: 14
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: fourteen patients requiring extraction of one posterior tooth with lost buccal bone (\>50%) confirmed preoperatively by Cone-beam computed tomography (CBCT) scans. Extraction sockets were filled with minced PRF clots mixed with the bovine xenograft and covered by PRF membranes to seal the extraction sockets. (CBCT) scans, performed before tooth extraction and after 6 months, were used to assess vertical and horizontal bone changes.


Eligibility criteria: Inclusion Criteria:

* Patients required implant treatment after tooth extraction
* Age group ranged from 20-60 years old.
* Patients could undergo the treatment under local anesthesia.
* Loss of buccal bone (\>50%) confirmed by preoperative cone beam computed tomography (CBCT).
* Presence of other socket walls; mesial, distal and lingual walls.
* Tooth needed to be extracted in upper or lower posterior regions

Exclusion Criteria:

* Uncontrolled diabetic diseases.
* Uncontrolled hypertension, or hepatic and renal disorders.
* Any systemic diseases associated with bone metabolism.

Primary outcomes:
measure: the change in alveolar bone width and height in mm using CBCT scans.
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Future University in Egypt
Study officials:
References:
Clinical trial NCT00285623: Observational Cohort Study of TachoSil (TC-018-IN)
Official title: An Non-interventional, Prospective, Non-controlled Study of the Use of TachoSil in Supportive Treatment in Surgery for Improvement of Haemostasis Where Standard Techniques Are Insufficient.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Blood Loss, Surgical
Keywords: Collection of all thromboembolic events,
immunological events and drug interactions leading to thromboembolic events or major
bleeding after exposure to TachoSil®.
Lead sponsor: Nycomed
Sponsor class: INDUSTRY
First posted: 2006-02-02
Enrollment: 3000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients exposed to TachoSil® of all thromboembolic events, immunological events and drug interactions leading to thromboembolic events or major bleeding.

Brief summary: The purpose of this study is to collect information, after exposure to TachoSil ®, of all thromboembolic events, immunological events and drug interactions leading to thromboembolic events or major bleeding. In addition, pharmacoeconomic data will be collected.


Eligibility criteria: Inclusion Criteria:

* All subjects, treated with TachoSil ® by the participating physicians, will be registered with a set of basic data from their already existing data (i.e. no additional diagnostic procedures will be performed).
* Subjects who will provide their written informed consent to use existing data, allow direct access to data and data processing.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Roskilde
country: Denmark
facility: Nycomed
Study officials:
affiliation: Headquarters
name: Nycomed Clinical Trial Operations
role: STUDY_CHAIR
References:
citation: Birth M, Figueras J, Bernardini S, Troen T, Gunther K, Mirza D, Mortensen FV. Collagen fleece-bound fibrin sealant is not associated with an increased risk of thromboembolic events or major bleeding after its use for haemostasis in surgery: a prospective multicentre surveillance study. Patient Saf Surg. 2009 Jun 22;3(1):13. doi: 10.1186/1754-9493-3-13.