Clinical trial NCT06476873: Substance Use Disorder in Chemsex Practice
Official title: Substance Use Disorder in Chemsex Practice: Evaluation of the Prevalence of the Disorder Among Users Via an Online Self-questionnaire
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Addiction Chemical
Use, Substance
Lead sponsor: Centre Hospitalier Charles Perrens, Bordeaux
Sponsor class: OTHER_GOV
First posted: 2024-06-27
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: cohort
Primary purpose: OTHER

Brief summary: The main aim of this descriptive cross-sectional study is to assess the prevalence of chemsex substance use disorder among chemsexers via an online self-questionnaire.

Detailed description: Chemsex appeared in Europe around 2006 and in France in 2010. It involves the use of psychoactive substances in a sexual context to enhance, initiate, facilitate or prolong sexual intercourse through the psychoactive effects of the molecules consumed. These molecules are essentially synthetic cathinones, GHB/GBL, MDMA, methamphetamines, cocaine and ketamine. These products are often used in combination with erectile dysfunction treatments (side effects of the molecules). This practice is thought to affect almost 20% of MSM.

This use has numerous social, somatic, psychiatric and addictive consequences. Studies have mainly focused on infectious risks, psychiatric complications (e.g. anxiety and depression) or the prevalence of this phenomenon. However, no study has assessed the prevalence of chemsex-related substance use disorders among these users.

Eligibility criteria: Inclusion Criteria:

* Be 18 years of age or older.
* Proficiency in written French
* Have practised chemsex at least once in the last 12 months.
* Agree to participate in the study.

Exclusion Criteria:

* Have not experimented with chemsex in the last 12 months
* Participation in other ongoing research
* Insufficient written comprehension of French

Primary outcomes:
measure: DSM-5 diagnosis of substance use disorder for chemsex.
timeFrame: 1 day
Secondary outcomes:
measure: Describing the sociodemographic characteristics of this population
timeFrame: 1 day
measure: Describing the consumption practices of this population
timeFrame: 1 day
measure: Describing the sexual practices of this population
timeFrame: 1 day
measure: Explore the existence of chemsex use disorder as a clinical entity in its own right
timeFrame: 1 day
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: Centre Hospitalier Charles PERRENS
Study officials:
References:
citation: Diestelmann M, Zangl A, Herrle I, Koch E, Graw M, Paul LD. MDPV in forensic routine cases: Psychotic and aggressive behavior in relation to plasma concentrations. Forensic Sci Int. 2018 Feb;283:72-84. doi: 10.1016/j.forsciint.2017.12.003. Epub 2017 Dec 8.
citation: Blanc JV, Burdairon JD, Malandain L, Ferreri F, Mouchabac S, Adrien V. Attachment and Mental Health of Men Having Sex with Men Engaging in Chemsex: Is Substance Abuse Only the Tip of the Iceberg? J Homosex. 2024 Oct 14;71(12):2875-2894. doi: 10.1080/00918369.2023.2266086. Epub 2023 Oct 10.
citation: Serre A, Vuillot O, Eiden C, Gambier J, Berger A, Mathieu O, Nefau T, Sebbane M, Donnadieu-Rigole H, Peyriere H. Acute Psychiatric Disorders Related to Fake Cathinone: Ephylone. J Anal Toxicol. 2019 Aug 23;43(7):e1-e2. doi: 10.1093/jat/bkz020. No abstract available.
citation: Evers YJ, Van Liere GAFS, Hoebe CJPA, Dukers-Muijrers NHTM. Chemsex among men who have sex with men living outside major cities and associations with sexually transmitted infections: A cross-sectional study in the Netherlands. PLoS One. 2019 May 14;14(5):e0216732. doi: 10.1371/journal.pone.0216732. eCollection 2019.
citation: Gilbart VL, Simms I, Gobin M, Oliver I, Hughes G. High-risk drug practices in men who have sex with men. Lancet. 2013 Apr 20;381(9875):1358-1359. doi: 10.1016/S0140-6736(13)60882-X. No abstract available.