Clinical trial NCT04250272: Serratus Anterior Plane Block Versus Intercostal Nerve Block for Postoperative Analgesia
Official title: Serratus Anterior Plane Block vs. Intercostal Nerve Block for Postoperative Analgesic Effect After Video-assisted Thoracoscopic Lobectomy: A Randomized Prospective Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Analgesia
Postoperative Pain
Lung Cancer
Lead sponsor: Kyungpook National University Hospital
Sponsor class: OTHER
First posted: 2020-01-31
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A prospective randomized controlled study was undertaken to compare the postoperative analgesic effect between ultrasound-guided serratus anterior plane block and intercostal nerve block after video-assisted thoracoscopic lobectomy.

Detailed description: Post-thoracotomy pain is one of the most notorious postsurgical pains that one can experience. The pain is known to last for an extensive period of time with significantly high intensity.

In field of thoracic surgery, video-assisted thoracoscopic surgery has been played an important role in alleviating the postoperative pain. In field of anesthesiology, various attempts to alleviate post-thoracotomy pain have been tried along advancement of thoracic surgical techniques. It began with postoperative medication of non-steroid anti-inflammatory drugs, opioids and progressed into implementations such as local analgesia, thoracic epidural block, paravertebral block, intercostal nerve block, interpleural block and serratus anterior plane block.

Many analgesic methods have been applied to alleviate postoperative pain in patients who have undergone thoracoscopic surgeries. However, there are no prospective randomized controlled studies between intercostal nerve block and serratus anterior plane block in video-assisted thoracoscopic lobectomy. The main purpose of this study is to compare and analyze the effects between conventional intercostal nerve block and newly introduced serratus anterior plane block in lung cancer patients who have undergone video-assisted thoracoscopic lobectomy.

This prospective study will discover the efficacy and differences between two methods.

Eligibility criteria: Inclusion Criteria:

* lung cancer
* American Society of Anesthesiologists (ASA) I-III class
* Video-assisted thoracoscopic lobectomy

Exclusion Criteria:

* previous history of allergy to local anesthetics
* psychological disorder
* chronic analgesics or sedatives use
* coagulopathy
* The presence of systemic infection or local infection at injection site
* Pregnancy

Primary outcomes:
measure: Postoperative pain: numeric rating scale
timeFrame: at postanesthesia care unit (PACU)
measure: Postoperative pain: numeric rating scale
timeFrame: 3 hours later operation
measure: Postoperative pain: numeric rating scale
timeFrame: 6 hours later operation
measure: Postoperative pain: numeric rating scale
timeFrame: 12 hours later operation
measure: Postoperative pain: numeric rating scale
timeFrame: 24 hours later operation
Secondary outcomes:
measure: Number of analgesics consumption
timeFrame: through study completion, an average of 1 yea
measure: Amount of analgesics consumption
timeFrame: : through study completion, an average of 1 year
Other outcomes:
Locations:
city: Daegu
country: Korea, Republic of
facility: Kyungpook national university hospital
Study officials:
affiliation: Kyungpook National University Hospital
name: Saeyoung Kim
role: PRINCIPAL_INVESTIGATOR
References: