Clinical trial NCT06663423: Impact of Anxiety and Depression on Implicit and Explicit Memory Performance
Official title: Cohort Study on the Differential Impact of Anxiety and Depression on Implicit and Explicit Memory Performance
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Generalized Anxiety Disorder (GAD)
Memory Bias
Implicit Memory
Explicit Memory
Keywords: Anxiety
Depression
Cognitive Bias
Memory Processing
Emotional Influence on Memory
Word Recognition Task
Mood-Congruent Memory
Psychological Disorders
Lead sponsor: Islamic Azad University, Sanandaj
Sponsor class: OTHER
First posted: 2024-10-29
Enrollment: 27
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A sample of individuals from Tehran Institute of Psychiatry and Shahid Esmaili Clinic, including patients with depressive disorder, generalized anxiety disorder, and a control group of healthy individuals with no history of emotional disorders.

Brief summary: This study examines the effect of anxiety and depression on memory processes, focusing on implicit and explicit memory. Implicit memory involves unconscious recall, such as recognizing familiar words without effort, while explicit memory requires conscious recollection of specific information. The study aims to investigate whether individuals with depression and anxiety show differences in these types of memory, which may contribute to biases related to their emotional states.

Participants were divided into three groups: individuals with depressive disorder, individuals with generalized anxiety disorder, and a control group with no emotional disorders. Each group was assessed using tasks designed to measure both implicit and explicit memory performance. The goal is to enhance understanding of memory biases in individuals with depression and anxiety, potentially supporting more targeted interventions.

Detailed description: This cohort study is designed to explore potential memory biases in individuals with depressive and anxiety disorders compared to a control group. The study includes 27 participants divided into three groups: nine individuals diagnosed with major depressive disorder, nine with generalized anxiety disorder, and nine control subjects with no history of emotional disorders. All participants were matched by age and education level.

Participants completed standardized tasks and assessments, including the Spielberger State-Trait Anxiety Inventory and various memory tasks such as word decoding and recognition memory tasks. These tasks aim to evaluate mood-congruent biases in memory recall. Data collection will focus on analyzing any distinct memory processing patterns in depression and anxiety to improve psychological treatment approaches.

Eligibility criteria: Inclusion Criteria:

* Adults aged 18 years or older
* Individuals diagnosed with major depressive disorder (Group 1)
* Individuals diagnosed with generalized anxiety disorder (Group 2)
* Healthy individuals with no history of emotional disorders (Group 3)

Exclusion Criteria:

* History of neurological disorders
* Visual impairments
* Substance abuse or drug addiction
* Psychiatric hospitalizations unrelated to primary diagnosis (for Groups 1 and 2)

Primary outcomes:
measure: Explicit Memory Bias
timeFrame: At a single time point during the experimental session, approximately 1 day
Secondary outcomes:
measure: Implicit Memory Bias
timeFrame: At a single time point during the experimental session, approximately 1 hour
Other outcomes:
measure: Mood Congruence in Recognition Performance
timeFrame: At a single time point during the experimental session, approximately 1 hour
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Tehran Institute of Psychiatry and/or Shahid Esmaili Clinic.
Study officials:
References: