Clinical trial NCT03261882: Loss of a Healthy Weight Advantage Among Mexican-American Children
Official title: Loss of a Healthy Weight Advantage Among Foreign-born Children of Mexican Origin: Analysis of Overweight/Obesity Trends From 1988-1994 to 2005-2014
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Overweight and Obesity
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
name: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
First posted: 2017-08-25
Enrollment: 11987
Sex: ALL
Minimum age (years): 4
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Data came from the National Health and Nutrition Examination Surveys (NHANES), a series of repeated cross-sectional surveys conducted by the U.S. Centers for Disease Control and Prevention. The investigators used data from NHANES III (1988-1994) and 5 pooled survey cycles from the continuous NHANES (2005-2014) to represent the two survey periods under study over 20 years apart. These analyses were restricted to Mexican-Americans and non-Hispanic White children aged 4-17 years. Out of the 12,006 Mexican-Americans and white children who attended the clinical examination in NHANES III and the continuous NHANES (2005-2014), those who reported being pregnant were excluded from analyses (N=19). Our final analytic sample included 6,280 Mexican-Americans and 5,707 White children across the two survey periods (2,704 Mexican-Americans and 2,014 White children in 1988-1994; 3,576 Mexican-Americans and 3,693 White children in 2005-2014)

Brief summary: Although research indicates foreign-born Mexican-Americans possess a healthy weight advantage relative to U.S.-born Mexican-Americans, patterns are less clear for children and may be changing over time. The objective of this study was to examine whether the relationship between nativity and overweight/obesity has changed over time among Mexican-American children and to investigate the implications of this pattern on overweight/obesity disparities relative to non-Hispanic Whites. Using cross-sectional data from Mexican-Americans and non-Hispanic white children ages 4-17 years participating in the National Health and Nutrition Examination Surveys (1988-1994 (N=4,718) and 2005-2014 (N=7,269), the investigators used log-binomial regression to calculate prevalence ratios (PR) of overweight/obesity by nativity status adjusting for age, sex, householder marital status, householder education, survey period and a nativity by survey period interaction. The investigators also tested another covariate-adjusted model with a 3-level ethnicity-nativity variable that included Whites and an ethnicity-nativity by survey period interaction.


Eligibility criteria: Inclusion Criteria:

* Mexican-Americans and white children who attended the clinical examination in NHANES III and the continuous NHANES

Exclusion Criteria:

* Reported being pregnant

Primary outcomes:
measure: overweight/obesity
timeFrame: 1988-1994 and 2005-2014
Secondary outcomes:
Other outcomes:
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