Clinical trial NCT04712162: The Quality of Recovery After General Anesthesia With Desflurane and Sevoflurane in Endoscopic Ureteral Lithotripsy
Official title: The Quality of Recovery After General Anesthesia With Desflurane and Sevoflurane in Endoscopic Ureteral Lithotripsy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anesthesia
Lead sponsor: Gia Dinh People Hospital
Sponsor class: OTHER
First posted: 2021-01-15
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The good quality of recovery after general anesthesia is one of goals for short procedures and ambulatory surgeries. The study's objective was to compare the quality of recovery after general anesthesia with desflurane and sevoflurane with laryngeal mask airway for endoscopic ureteral lithotripsy.

Detailed description: This is a randomized controlled trial. There were 60 cases of endoscopic ureteral lithotripsy under general anesthesia with laryngeal mask airway were enrolled. All cases were randomly divided into two group (desflurane or sevoflurane). Each group had 30 cases. Primary outcome was time to awakening. Secondary outcomes were time to wash-out of volatile anesthetics, time to extubation, irritation after awakening, and modified Aldrete score.

Statistical analysis was performed by using Kaplan-Meieir curve and log-rank test for time to adequate depth of anesthesia and time to awakening; t-test for time to wash-out of volatile anesthetics; chi-square test for depth of anesthesia by PRST score, irritation after awakening and Aldrete score; Fisher test for adverse effects of volatile anesthetics.

The research was approved by Gia Dinh People Hospital ethics committee

Eligibility criteria: Inclusion Criteria:

* All eligible subjects who underwent endoscopic ureteral lithotripsy under general anesthesia
* ASA I and II

Exclusion Criteria:

* Contraindication to laryngeal mask airway.
* Indication for conversion to tracheal intubation during surgery.
* History of malignant hyperthermia.
* Pregnancy.
* Obese (BMI \>25 kg/m2).
* Substances abuse.

Primary outcomes:
measure: Time to awakening
timeFrame: After stopping volatile anesthetics to patient awakening, up to 30 minutes.
Secondary outcomes:
measure: Time to wash-out of volatile anesthetics
timeFrame: After stopping volatile anesthetics to complete wash-out of volatile anesthetics, up to 30 minutes
measure: Time to extubation
timeFrame: After stopping volatile anesthetics to readiness for extubation, up to 30 minutes
measure: Irritation after awakening
timeFrame: After awakening to eligible discharge, up to 2 hours.
measure: Adverse effects of volatile anesthetics
timeFrame: After providing volatile anesthetics until they were stopped, up to 90 minutes
Other outcomes:
Locations:
city: Ho Chi Minh City
country: Vietnam
facility: Anesthesiology Department of Gia Dinh People Hospital
Study officials:
affiliation: Gia Dinh People Hospital
name: Thanh T. Nguyen, PhD
role: STUDY_CHAIR
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