Clinical trial NCT02276976: MRI,Gene And Cognitive Performance Study of Patients With Cerebral White Matter Lesions(WMLs)
Official title: MRI,Gene And Cognitive Performance Study of Patients With Cerebral White Matter Lesions
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cerebral White Matter Lesions
Keywords: crebral white matter lesions
brain networks
MRI
DTI
fMRI
cognitive impairment
gene
Lead sponsor: Huazhong University of Science and Technology
Sponsor class: OTHER
First posted: 2014-10-28
Enrollment: 200
Sex: ALL
Minimum age (years): 40
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with cerebral white matter lesions

Brief summary: The purpose of this study is:1)to observe topological organization in brain structural and functional networks in cerebral white matter lesion patients and to evaluate the association between impairment of cognitive function and cerebral structural and functional networks in those patients;2)to indicate the role of genetic factors in the occurrence and prognosis of cerebral white matter lesions

Detailed description: 100 patients with cerebral white matter lesions and 100 normal controls will be observed. All of them will receive MRI scan(T1WI,T2WI,T2flair,MRA,SWI,ASL,DTI and fMRI) and the assessment of the neuropsychological function (MMSE,Auditory verbal memory test,Trail-making test-A and -B,Symbol digit modalities test,Digit span test,Clock drawing test,HAMD) intending to analyse topological organization in brain structural and functional networks in cerebral white matter lesion patients and to evaluate the association between impairment of cognitive function and cerebral structural and functional networks in those patients.Furthermore,DNA will be extracted from the blood sample of all participates to perform High-throughput sequencing. MRI scan and neuropsychological function assessment will be performed repeatedly after 1,3 and 5 years.

Eligibility criteria: Inclusion Criteria:

* MRI diagnosis of cerebral white matter lesions Must be able to measure his(her) neuropsychologic function No severe stroke history and no physical disability Patients aged 40 to 85 Based on China's relevant laws, the patient himself agreed to participate in this study, a good compliance.Patients himself/herself must sign informed consent moreover

Exclusion Criteria:

* Unable to undergo examinations due to disturbances of consciousness or medical conditions Serious complications including severe heart failure, hepatic dysfunction, renal insufficiency,or shock AD,Parkinson's disease, malignant tumor, MS and other autoimmune diseases toxic and metabolic encephalopathy cerebral white matter lesions caused by CADASIL and other confirmed monogenic disease

Primary outcomes:
measure: MRI and cognitive function scale
timeFrame: up to 5 years after first assessment
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Department of Neurology of Tongji Hospital, Huazhong University of Science and Technology
state: Hubei
Study officials:
affiliation: Tongji Hospital
name: Wei Wang, Doctor
role: PRINCIPAL_INVESTIGATOR
References: