Clinical trial NCT06246994: Predictors of Mortality Among Ventilator Associated Pneumonia Patients
Official title: Predictors of Mortality Among Ventilator Associated Pneumonia Patients
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Pneumonia
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-02-07
Enrollment: 140
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: This study will enroll adult participants over 18 years old who had undergone mechanical ventilation for longer than 48 hours. Only the first episode of VAP for each patient will be included.

Brief summary: In this context, this study aims to explore the risk factors for mortality from VAP in respiratory ICU.

Detailed description: Pneumonia is the most common infection treated within ICUs and carries significant mortality risk . Ventilator-associated pneumonia (VAP) is a specific form of nosocomial pneumonia occurring in patients greater than 48 hours after intubation and the initiation of mechanical ventilation .

VAP is considered a leading cause of morbidity and mortality among intensive care unit infections. Despite various preventive measures, the incidence of VAP remains high .

In studies, VAP-related mortality is 14-70% . It is contemplated that there are independent risk factors, increasing VAP-related mortality .

However, the question of which factors are associated with early or late mortality in patients with VAP diagnosis, remains unanswered. Early identification and understanding of the etiology of VAP in the ICU is essential to prevent mortality and morbidity.

Eligibility criteria: Inclusion Criteria:This study will enroll:

1. adult participants over 18 years old who had undergone mechanical ventilation for longer than 48 hours.
2. Only the first episode of VAP for each patient will be included.

Exclusion Criteria:

1. Patients who are less than 18 years old.
2. Pneumonia diagnosed before mechanical ventilation.

Primary outcomes:
measure: Mortality rate at 28 days.
timeFrame: 28 days
measure: Percentage of risk factors of VAP mortality.
timeFrame: 28 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Assiut University
name: Doaa Magdy, assisst -professor
role: STUDY_DIRECTOR
References:
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citation: Zimmerman JE, Kramer AA, McNair DS, Malila FM, Shaffer VL. Intensive care unit length of stay: Benchmarking based on Acute Physiology and Chronic Health Evaluation (APACHE) IV. Crit Care Med. 2006 Oct;34(10):2517-29. doi: 10.1097/01.CCM.0000240233.01711.D9.