louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02515812: Comparative Study of Cardiac Adrenergic Function Explored by I-123-MIBG and CZT Camera (D-SPECT) Versus Anger Camera in Patients With Heart Failure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Failure
Lead sponsor: University Hospital, Caen
Sponsor class: OTHER
First posted: 2015-08-05
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: Cardiological examination constitute one of the major directions in nuclear medicine for detection of myocardial ischemia in patients suspected of coronary disease. In Caen, they constitute 20% of the activity of nuclear medicine. Systolic heart failure (HF) ischemic or nonischemic origin represents a new area of activity of the nuclear cardiology. This is HF stratification study based on cardiac adrenergic function after injection of a tracer: I-123-MIBG. The team Caen nuclear cardiology is one of two teams recognized internationally in the field of evaluating the cardiac sympathetic innervation in cardiomyopathies. Numerous publications from 1992 to the present day have reported encouraging results for the daily use of this tracer in the evaluation of patients with LV dysfunction IC. Recently, interest in using the MIBG has been shown as a prognostic marker of HF in a prospective study of 961 patients. Typically, the camera used was an Anger camera with collimating Nai standard called parallel holes.

The main objective is to validate the measurements of cardiac adrenergic function evaluated by cardiopulmonary mediastinal reports and sympathetic innervation scores VG after injection of I-123-MIBG in 80 patients with heart failure.


Eligibility criteria: Inclusion Criteria:

* Age above 18 years (except major patients under guardianship)
* patient who signed the consent form
* written and spoken French
* Beneficiaries of the social security system
* Stable heart failure with LV dysfunction (\<45%) of ischemic or nonischemic origin

Exclusion Criteria:

* Patients with a recent history (\<21 days) acute coronary failure (myocardial infarction, unstable angina)
* Patients with severe extra-cardiac disease may interfere with treatment decisions (cancer, severe hepatic or renal impairment)
* Major patients under guardianship
* Pregnant or lactating women
* Women in age and condition of childbearing
* Patients unable to understand the purpose of the study

Primary outcomes:
measure: SRSI (summed rest score innervation)
timeFrame: 4 hours after I-123-MIBG perfusion
measure: SRS (summed rest score)
timeFrame: 4 hours after I-123-MIBG perfusion
Secondary outcomes:
Other outcomes:
Locations:
city: Caen
country: France
facility: Médecine Nucléaire -CHU de Caen
Study officials:
References:
Clinical trial NCT04803812: Supporting the Wellness of Ontario Physicians During COVID-19
Official title: Supporting the Wellness of Ontario Physicians During COVID-19
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mental Health Wellness 1
Anxiety
Happiness
Lead sponsor: Ontario Medical Association
Sponsor class: OTHER
Collaborators: name: The Behavioural Insights Team
First posted: 2021-03-18
Enrollment: 19124
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: In light of the coronavirus pandemic, the challenge of physician burnout has taken on a new urgency. Long-hours and difficult, sometimes unsafe work conditions are creating a severe strain for emergency physicians and others on the frontlines of Ontario's response to COVID-19. There are a variety of evidence-informed ways that physicians can protect their wellbeing with modest investments of time and energy that will be applied. The evaluation will be a randomized trial comparing the outcomes from each of the three treatment arms. Researchers may also use a pre-post comparison with control parameters to conduct an exploratory analysis to assess efficacy.


Eligibility criteria: Inclusion Criteria:

* Active membership to the Ontario Medical Association (OMA). Up-to-date cell phone information registered to the OMA.

Exclusion Criteria:

* Participation in the OMA Physician Burnout Task Force. Opt-out from the intervention.

Primary outcomes:
measure: Wellbeing (Short Warwick-Edinburgh Mental Well-being Scale measure)
timeFrame: 6 months
Secondary outcomes:
measure: Happiness (UK ONS measure)
timeFrame: 6 months
measure: Anxiety (UK ONS measure)
timeFrame: 6 months
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Ontario Medical Association
state: Ontario
Study officials:
affiliation: Ontario Medical Association
name: James Wright
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00151112: Comparison of Two Different Procedures for Plexus Anesthesia
Official title: Comparison of Two Different Procedures for Plexus Anesthesia: Standard Position Versus Combination of Lateral Position and 20° Trendelenburg Position
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Wounds and Injuries
Keywords: nerve block
regional anesthesia
injuries
diverse malformations
Lead sponsor: University Hospital Muenster
Sponsor class: OTHER
First posted: 2005-09-08
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to investigate the influence of difference positioning on extension and efficacy of brachial plexus anesthesia at 20 minutes by using the axillary plexus block with supine positioning and a lateral positioning onto the non-anaesthetized side, combined with 20° Trendelenburg positioning.


Eligibility criteria: Inclusion Criteria:

* Single shot axillary block

Exclusion Criteria:

* Lateral position not possible

Primary outcomes:
measure: Extent of anesthesia
timeFrame: 20 minutes after acillary plexus block
measure: Efficacy of anesthesia
timeFrame: 20 minutes after axillary plexus block
Secondary outcomes:
measure: Rate of failure
timeFrame: 20 minutes after axillary plexus block
Other outcomes:
Locations:
city: Murnau
country: Germany
facility: BG Unfallklinik Murnau; Department of Anesthesiology
city: Münster
country: Germany
facility: Department of Anesthesiology and Intensive Care, University Hospital Münster
Study officials:
affiliation: Department of Anesthesiology and Intensive Care, University Hospital Münster
name: Thomas Weber, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bullmann V, Waurick R, Rodl R, Hulskamp G, Orlowski O, van Aken H, Winkelmann W, Weber TP. [Corrective osteotomy of the humerus using perivascular axillary anesthesia according to Weber in a patient suffering from McCune-Albright syndrome]. Anaesthesist. 2005 Sep;54(9):889-94. doi: 10.1007/s00101-005-0874-6. German.
Clinical trial NCT01000012: Compassionate Use of the Becker Expander/Breast Implant
Official title: Compassionate Use of the Becker Expander/Breast Implant
Study type: EXPANDED_ACCESS
Overall status: NO_LONGER_AVAILABLE
Conditions: Breast Reconstruction
Lead sponsor: Mentor Worldwide, LLC
Sponsor class: INDUSTRY
First posted: 2009-10-22
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT

Brief summary: To provide access of the Becker Expander/Breast implant to women who do not meet inclusion/exclusion criteria of the Becker Continued Access Study

Patients' physician will contact Mentor to request use of the device and each request will be reviewed by Mentor, an IRB, and the FDA on a case-by-case basis


Eligibility criteria: Inclusion Criteria:

* Women who require a Becker Expander/Breast implant who do not meet inclusion/exclusion criteria of the Becker Continued Access Study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Santa Barbara
country: United States
facility: Mentor Worldwide LLC
state: California
Study officials:
References:
Clinical trial NCT00771212: Observational Study on the Patients With Pain Medications
Official title: Observational Study on the Patients With Pain Medications
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pain
Keywords: Pain
Observational
Taiwan
Lead sponsor: Johnson & Johnson Taiwan Ltd
Sponsor class: INDUSTRY
First posted: 2008-10-13
Enrollment: 2636
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Outpatients; Patients must have pain, previously treated with and without medication and have a VAS (Visual analogue scale) score recorded at the enrolment time; Patient must have a VAS score \>4

Brief summary: The purpose of this study is to describe the use of pain treatments in Taiwan, the demographics, clinical characteristics of patients requiring pain treatments, current treatments, outcomes of treatments and the reasons for changing pain medication during treatment.

Detailed description: This is a Phase IV, multi-center, observational study to describe the use of pain treatments, the demographics, clinical characteristics of patients requiring pain treatments, current treatments, outcomes of treatments and the reasons for changing pain medication during treatment. The study is conducted in an effort to understand the status of pain control in Taiwan. Currently in Taiwan, there is no approved documentation showing the most effective standard medication for treatment of patients in pain. Observational study with no study medication administered.

Eligibility criteria: Inclusion Criteria:

* Outpatients only
* Patients must have pain, previously treated with and without medication and have a VAS (Visual analogue scale) score recorded at the enrolment time
* Patient must have a VAS score \>4

Exclusion Criteria:

* Patients who are receiving any investigational drug during the study
* Patients with known or suspected psychotic disease or mental retardation.

Primary outcomes:
measure: To describe effective use of pain medications, describe demographics, clinical characteristics of patients requiring pain treatments, current treatments, outcomes of treatments and the reasons for changing pain medication during treatment in Taiwan
timeFrame: 60 days
Secondary outcomes:
measure: Pain Relief Rating Scale
timeFrame: 60 days
measure: Sleeping quality Assessment
timeFrame: 60 days
measure: Global Assessments (Patient/Investigator)
timeFrame: 60 days
Other outcomes:
Locations:
Study officials:
affiliation: Johnson & Johnson Taiwan Ltd
name: Johnson & Johnson Taiwan, Ltd. Clinical Trial
role: STUDY_DIRECTOR
References:
Clinical trial NCT01209312: Timing of Pre-meal Insulin Versus Accurate Carbohydrate Counting in Youth With Type 1 Diabetes
Official title: Timing of Pre-meal Insulin Versus Accurate Carbohydrate Counting in Youth With Type 1 Diabetes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Type 1 Diabetes
Lead sponsor: University of Colorado, Denver
Sponsor class: OTHER
First posted: 2010-09-27
Enrollment: 21
Sex: ALL
Minimum age (years): 7
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The investigators are hoping to figure out how youth with type 1 diabetes can best control their blood glucose levels after meals, by determining whether accurate carbohydrate dosing or the timing of the bolus is more important. There is evidence to suggest that each strategy is important for blood glucose control. Unfortunately, for some people, prebolusing is difficult, because they may not know how much they are going to eat. To give an exact dose of insulin 20 minutes before a meal can be difficult. In this study, the investigators would like to show that taking even just part of the insulin bolus 20 minutes before the meal is preferable to waiting until mealtime and taking the entire bolus. To do this, the investigators will have 24 patients in the study, who will each spend 4 mornings at The investigators clinic. The order of the visits will be selected randomly. The visits will include: taking full bolus at mealtime, taking full bolus 20 minute before mealtime, taking ½ bolus at mealtime, and taking ½ bolus 20 minutes before mealtime. At each visit, the person will eat the same meal, but the timing and amount of the bolus will be different. The investigators will measure the blood glucose levels with a blood glucose meter, and also with a laboratory test called YSI. The investigators will also be measuring the glucose levels under the person's skin with a continuous glucose monitor. The investigators will compare the area under the curve for the different visits, as well as the glucose levels at different points after the meal.


Eligibility criteria: Inclusion Criteria:

* Ages 7-21, inclusive
* Diagnosis of type 1 diabetes for \>1 year
* Using carbohydrate counting to dose mealtime insulin
* Using an insulin pump and continuous glucose monitor to control diabetes
* HbA1c \<10%

Exclusion Criteria:

* Celiac disease or other GI abnormality
* Severe hypoglycemia in the past 6 months
* Pregnancy
* Documented hypoglycemia unawareness

Primary outcomes:
measure: Blood glucose area under the curve
timeFrame: 4 hours post-meal
Secondary outcomes:
Other outcomes:
Locations:
city: Aurora
country: United States
facility: Barbara Davis Center for Childhood Diabetes
state: Colorado
Study officials:
affiliation: University of Colorado, Denver
name: H Peter Chase, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04007146: Systematic Calculation of HyperOxygenation Transit Time
Official title: Systematic Calculation of HyperOxygenation Transit Time Mesure transcutanée de l'oxygène au Cours de l'Hyperoxie Transitoire
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Cardiac Output
Keywords: Cardiac Output
vascular medicine
Transcutaneous Oxymetry
Lead sponsor: University Hospital, Angers
Sponsor class: OTHER_GOV
First posted: 2019-07-05
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Cardiac output (CO) is an essential physiological parameter of healthy person or illness.

In clinical practices, all methods of measuring the CO(Fick method, thoracic impedance, esophageal echodoppler etc) contain limit. Each method are dangerous or hard to implement.

CO is probably determining element of blood transit time and thus the availability of oxygen between the central organs (heart, lung) and the peripheral organs (leg, arms).

Our hypothesis is transcutaneous oxymetry mesurement with oxygen inhalation, to cause a transient hyperoxia, can be used to determinate blood transit time between central organs and peripheral organs. This simple method will be non invasive technique.

Detailed description: At admission eligible patients are proposed to participate. Written consent is signed after complete oral and written explanation of the protocol is signed.

The time of onset hyperoxia will be compare to usual CO method by cross correlation.

The duration of participation for subject is equal to 1 hour.

Eligibility criteria: Inclusion Criteria:

* Adults over 18
* Cardiac output measurement considered at least 2 hours prior to the study
* Affiliation to a French National healthcare system
* Written informed consent must be obtained prior to protocol-specific

Exclusion Criteria:

* Acute or decompensated cardiac or respiratory failure
* Allergy to medical adhesives
* Patients under reinforced protection, pregnancy, deprived of liberty by judicial or administrative decision, hospitalized without consent or admitted to a health or social establishment for purposes other than research
* Inability to understand the instructions or objectives of the study

Primary outcomes:
measure: Estimation of transcutaneous oxymetry with transient hyperoxia
timeFrame: 24 months
measure: Average of CO measured
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Angers
country: France
facility: Centre hospitalier universitaire
Study officials:
affiliation: University Hospital in Angers
name: Pierre MD ABRAHAM, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05998746: Comparison of ASA and CFS in Anesthesiology
Official title: Comparison of ASA and CFS in Predicting Peri- and Postoperative Outcomes in Elective Patients Older Than 65 Years
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Frailty
Keywords: American Society of Anesthesiologists physical status;
Clinical frailty
Elderly
Treatment outcome
Lead sponsor: Osijek University Hospital
Sponsor class: OTHER
First posted: 2023-08-21
Enrollment: 200
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study population is all elective patients of the Osijek University Hospital older then 65 years who were included during the preoperative examination.

Brief summary: In addition to the regular ASA classification, patients would also be assigned the Clinical frailty scale (CFS) during preoperative examinations in anesthesiology clinics. The aim is to compare the usefulness of ASA and CFS categorization for predicting perioperative and postoperative complications and length of postoperative stay in elective surgeries.

Detailed description: CFS significantly correlates with complications in patients treated in emergency department. This study is expected to provide information on how CFS correlates with complications and length of stay in elective surgeries.

In addition to the regular ASA classification, patients would also be assigned the Clinical frailty scale (CFS) during preoperative examinations in anesthesiology clinics.

The respondents are all elective patients over 65 years of age who have not had previously recorded mental difficulties that interfere with their daily life. Patients suffering from senile dementia would not be excluded from this study.

After the treatment was completed, the medical history of each patient would be reviewed and statistically processed.

The aim is to compare the usefulness of ASA and CFS categorization for predicting perioperative and postoperative complications and length of postoperative stay in elective surgeries.

Eligibility criteria: Inclusion Criteria:

* All elective patients older then 65 years

Exclusion Criteria:

* Earlier mental difficulties that affect everyday life, senile dementia is not exclusion criteria

Primary outcomes:
measure: Peri- and postoperative complications
timeFrame: During 2 months after elective operation
Secondary outcomes:
measure: Length of stay in hospital
timeFrame: During 2 months after elective operation
Other outcomes:
Locations:
city: Osijek
country: Croatia
facility: University Hospital Centre Osijek
Study officials:
affiliation: Osijek University Hospital; Medical Faculty Osijek
name: Slavica Kvolik, MD
role: STUDY_CHAIR
References:
Clinical trial NCT02893046: HCV Care Pathway in Ile-de-France
Official title: HCV Care Pathway in Ile-de-France
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hepatitis C Virus
Keywords: care pathway
hospital- private network
early consultation
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
Collaborators: name: Agence Regionale de Sante d'Ile de France
First posted: 2016-09-08
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients newly screened positive for HCV among private practitioners, screening and diagnostic centers, precarious consultations addictology structures, associations of patients or medical units detention centers.

Patients already diagnosed positive for HCV but not monitored in a care sector will also be included in the pathway

Brief summary: The main objective of this research is to evaluate a care pathway adapted to different category populations at risk of being infected with the hepatitis C virus in order to improve both the diagnosis turnaround times and the access to treatment. The aim is to allow a quick and effective access to diagnosis and treatment of HCV by strengthening the city hospital networks, access to early consultations and coordination of medical social actors.

Detailed description: The current estimation of infected persons with chronic hepatitis C in France is over 200 ,000. It appears that prevention, screening, care management, medical and social care of patients can be significantly improved especially among the most vulnerable populations. Indeed, these new HCV infections are mediated by drug-using people, prisoners, migrants, men who have sex with men (MSM) and who are supported too late and without real access to treatment.

Eligibility criteria: Inclusion Criteria:

* 18 years old and more
* Positive Hepatitis C virus
* Patient having expressed a non-objection to participate in this research

Exclusion Criteria: None

Primary outcomes:
measure: Number of patients effectively cared divided by number of patients eligible to care.
timeFrame: Year 3
Secondary outcomes:
measure: Number of patients cared in the HCV care pathway in Ile-de-France
timeFrame: Year 3
measure: Number of patients effectively treated divided by number of patients eligible to DAA treatment.
timeFrame: Year 3
measure: Delay between HCV diagnosis and early consultation
timeFrame: Year 3
Other outcomes:
Locations:
city: Creteil
country: France
facility: Henri Mondor Hospital
Study officials:
affiliation: Assistance Publique - Hôpitaux de Paris
name: Stéphanie DOMINGUEZ, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00952146: Transgastric Peritoneoscopy and Appendectomy
Official title: Transgastric Diagnostic Peritoneoscopy (Laparoscopy) and Appendectomy - A Pilot Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Abdominal Pain
Keywords: NOTES
Transgastric
Appendectomy
Safety
Feasibility
Lead sponsor: Sodra Alvsborgs Hospital
Sponsor class: OTHER
Collaborators: name: Borås Lasarett
First posted: 2009-08-06
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This study is a feasibility study. Patients with acute abdominal pain who are planning to undergo a diagnostic laparoscopy are asked to participate in the study. The aim of the study is to evaluate if transgastric peritoneoscopy is feasible.


Eligibility criteria: Inclusion Criteria:

* Patient with acute abdominal pain

Exclusion Criteria:

* Patient under 18
* Patient who cannot understand information in Swedish
* Patients previously operated in upper part of the abdomen

Primary outcomes:
measure: To test the feasibility of transgastric peritoneoscopy
timeFrame: When discharged from hospital, 1 month post-op and one year
Secondary outcomes:
Other outcomes:
Locations:
city: Boras
country: Sweden
facility: Department of Surgery, South Alvsborg Hospital
Study officials:
affiliation: South Alvsborg Hospital, Boras, Sweden
name: Per-Ola Park, MD&PhD
role: PRINCIPAL_INVESTIGATOR
References: