Clinical trial NCT03420391: PBMT on Muscular Performance and Recovery in Different Time-points
Official title: Effects of Photobiomodulation Therapy (PBMT) on Muscular Performance and Recovery in Different Time-points
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Phototherapy
Keywords: phototherapy
performance
muscular recovery
photobiomodulation therapy
time-window
Lead sponsor: University of Nove de Julho
Sponsor class: OTHER
Collaborators: name: Fundação de Amparo à Pesquisa do Estado de São Paulo
name: University of Bergen
First posted: 2018-02-05
Enrollment: 60
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Sixty participants will be enrolled in the study. Participants will be randomized in six groups:

Control: Participants will receive no intervention; Placebo: Participants will receive placebo PBMT; 5 minutes: Participants will perform the eccentric exercise protocol 5 minutes after PBMT.

3 hours: Participants will perform the eccentric exercise protocol 3 hours after PBMT.

6 hours: Participants will perform the eccentric exercise protocol 6 hours after PBMT.

24 hours: Participants will perform the eccentric exercise protocol 24 hours after PBMT.

Assessments will be performed at baseline, after 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.
Primary purpose: PREVENTION

Brief summary: Recent studies with photobiomodulation therapy (PBMT) have shown positive results delaying skeletal muscle fatigue and improving the status of biochemical markers related to skeletal muscle damage when these therapies were applied before exercise. The aim of this project is to verify the effects of PBMT in improvement of skeletal muscle performance and skeletal muscle recovery in healthy male subjects. This project aim also to validate the concept that simultaneous use of three wavelengths and light sources lead to optimized action independently of time-window between irradiation and the exercise.

Detailed description: This is a randomized, triple-blinded, placebo-controlled trial. Sixty healthy untrained male subjects will be randomly allocated to six experimental groups: Placebo, Control, PBMT 5 mins, PBMT 3h, PBMT 6h and PBMT 24 hours. PBMT will be applied precisely two minutes after baseline MVC test. Then, after five minutes, 3, 6 hours or 1 day (24 hours) of PBMT the eccentric exercise protocol will be performed. We will analyze maximum voluntary contraction (MVC), creatine kinase (CK) activity and delayed onset muscle soreness (DOMS). Assessments will be performed at baseline, immediately after (1 minute), 1 hour, 24 and 48 hours after the eccentric exercise protocol.

Eligibility criteria: Inclusion Criteria:

* Healthy
* not athletes or who engage in physical activity at most once a week
* Individuals should not present a history of musculoskeletal injury in the hip and knee regions in the two months prior to the studies
* they should not be using pharmacological agents and / or nutritional supplements
* They must attend 100% of the data collections.

Exclusion Criteria:

* Individuals who do not meet the criteria mentioned above or who present musculoskeletal damage during collection were excluded from the study.

Primary outcomes:
measure: Torque peak / maximum voluntary contraction - MVC
timeFrame: 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.
Secondary outcomes:
measure: Delayed onset muscle soreness (DOMS)
timeFrame: 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.
measure: Biochemical marker of muscle damage
timeFrame: 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Universidade Nove de Julho
Study officials:
References:
citation: Leal-Junior ECP, de Oliveira MFD, Joensen J, Stausholm MB, Bjordal JM, Tomazoni SS. What is the optimal time-response window for the use of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) for the improvement of exercise performance and recovery, and for how long the effects last? A randomized, triple-blinded, placebo-controlled trial. BMC Sports Sci Med Rehabil. 2020 Oct 19;12:64. doi: 10.1186/s13102-020-00214-8. eCollection 2020.