Clinical trial NCT03065608: Evaluation of C-reactive Protein Level in the Group of Patient With Pain Form of Temporomandibular Joint Dysfunction
Official title: Evaluation of C-reactive Protein Level in the Group of Patient With Pain Form of Temporomandibular Joint Dysfunction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Lead sponsor: Jagiellonian University
Sponsor class: OTHER
First posted: 2017-02-28
Enrollment: 72
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study enrolled a group of 72 patients, aged 21 to 48 years, of both sexes, who reported to the prosthodontic treatment in Consulting Room of Temporomandibular Joint Dysfunction at Dental Institute at Jagiellonian University in Cracow, between January 2015 to February 2017, due to the pain and painless form of the temporomandibular joints dysfunction, and acoustic symptoms, accompanied by excessive tension of masticatory muscle. Symptoms persisted from 3 to 12 months prior to beginning of the treatment.

Brief summary: Temporomandibular joints dysfunction is a functional disorder concern with the abnormal functioning of the muscles of the stomatognathic system, temporomandibular joints involved in the dynamic movements of the jaw and surrounding structures.

The aim of the study was to compare the level of C-reactive protein in patients with pain and painless form of temporomandibular joints dysfunction.

Detailed description: Temporomandibular joints dysfunction is a functional disorder concern with the abnormal functioning of the muscles of the stomatognathic system, temporomandibular joints involved in the dynamic movements of the jaw and surrounding structures.

The aim of the study was to compare the level of C-reactive protein in patients with pain and painless form of temporomandibular joints dysfunction.

Material and methods The research material consisted of 72 patients who reported to the prosthetic treatment because of temporomandibular joint dysfunction. The study group included 36 patients with pain form of dysfunction, and control group - 36 patients with painless form of disorder. Each patient underwent specialized examination of functional disorders, in order to diagnose the type of dysfunction and commissioned to carry out a study of the blood test concern with evaluation of the C-reactive protein (CRP) level in the same analytical laboratory.

The results of the investigation were subjected to statistical analysis.

Eligibility criteria: Inclusion Criteria:

* Factors of inclusion in the study are: pain form of temporomandibular joints dysfunction, the required age range, a good general state of health (particularly with regard to cardiac and metabolic disorders).

Exclusion Criteria:

* Factors for exclusion from the research include: the will of the patient, the emergence of general diseases, trauma, or local inflammation.

Primary outcomes:
measure: By means of the CRP-level it will be verified if the temporomandibular joint dysfunctions are associated with inflammations of the temporomandibular joints.
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Jagiellonian University
name: Małgorzata Pihut, Associate Professor
role: PRINCIPAL_INVESTIGATOR
affiliation: Jagiellonian University
name: Piotr Ceranowicz, MD,PhD,
role: STUDY_CHAIR
affiliation: Jagiellonian University
name: Andrzej Gala, DDS,PhD,
role: STUDY_CHAIR
affiliation: Wroclaw Medical University
name: Mieszko Więckiewicz, DMD,PhD,
role: STUDY_CHAIR
References: