Clinical trial NCT04370912: Using Bedside Ultrasound to Screen for Sarcopenia in Older Adults
Official title: Using Bedside Ultrasound to Screen for Sarcopenia in Older Adults
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sarcopenia
Lead sponsor: University of British Columbia
Sponsor class: OTHER
Collaborators: name: Canadian Institutes of Health Research (CIHR)
First posted: 2020-05-01
Enrollment: 152
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects will be recruited from Vancouver Coastal Health Authority has 5 outpatient geriatric medicine clinics that continuously for 5 days per week and see 4000 new patients per year.

Brief summary: The loss of both muscle mass and quality with increasing age is called 'sarcopenia' and is a risk factor for falls, fractures and increased mortality. Sarcopenia is diagnosed with Dual-energy X-ray absorptiometry (DXA) scanning (according to current criteria), but in Canada DXA scans are not approved to screen for this condition. One potential solution is Point of Care Ultrasound (PoCUS), since recent advances have made bedside ultrasound technology readily available as a rapid bedside screening tool.

Detailed description: Some recent work has examined the possibility of using ultrasound as a measure of both muscle quantity and muscle quantity. Work done by Strasser et al, has shown that ultrasonic measures of muscle thickness in the quadriceps muscle has a highly significant correlation with maximal voluntary contration. Other work done by Miron-Mombiela et al has shown that measures of muscle thickness and echointensity (a measure of muscle quality) also show high correlations with grip strength. These findings (supported by our pilot data, see Pilot Data) and new technological advances in bedside ultrasonic devices suggest that these measures might be a valuable contribution to the process of screening for sarcopenia in older adults. In this proposal, Investigators hypothesize that bedside ultrasound, which is increasingly becoming a mainstream component of the standard physical exam, will be a much more specific and accurate alternative to our current best screening methods.

Eligibility criteria: Inclusion Criteria:

* each subject must be 65 years of age or greater

Exclusion Criteria:

* hemodialysis patients will be excluded, due to excessive fluid shifts with dialysis
* patients using chronic oral corticosteroids will be excluded, due to potential muscle atrophy
* hemiparesis due to a stroke or paresis of the lower limbs will be excluded
* subjects with pitting edema on physical exam (due to liver, renal or heart failure) or patients that are severely dehydrated will be excluded
* patients with myositis, systemic connective tissue disorders, systemic atrophies affecting the central nervous system (CNS) and CNS demyelinating diseases will be excluded

Primary outcomes:
measure: US measurement for Sarcopenia
timeFrame: through study completion, an average of 1 year
measure: Weight in kg
timeFrame: through study completion, an average of 1 year
measure: Height in cm
timeFrame: through study completion, an average of 1 year
measure: Handgrip strength in kg
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Vancouver
country: Canada
facility: Vancouver Coastal Health Research Institute, VGH Research Pavilion Room 186
state: British Columbia
Study officials:
affiliation: UBC
name: Kenneth Madden, MD
role: PRINCIPAL_INVESTIGATOR
References: