louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01678612: Efficacy of Copper in Reducing Health-Acquired Infections in a Pediatric Intensive Care Unit
Official title: Efficacy of Copper in Reducing Health-Acquired Infections and Microbial Burden as Measured on High Touch Surfaces in a Pediatric Intensive Care Unit. A Controlled Clinical Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nosocomial Infections
Keywords: Copper
Health-Acquired Infections
Bacterial Load
Intensive Care Units, Pediatric
Lead sponsor: Codelco
Sponsor class: INDUSTRY
First posted: 2012-09-05
Enrollment: 1012
Sex: ALL
Minimum age (years): 7
Maximum age (years): 180
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Healthcare-acquired infections (HAI) cause substantial patient morbidity and mortality. Commonly touched items in the patient care environment harbor microorganisms that may contribute to HAI risk. The purpose of this study is to assess whether placement of copper-alloy surfaced objects in a pediatric intensive care unit (PICU) reduce risk of HAI in comparison with non-copper surfaced objects.


Eligibility criteria: Inclusion Criteria:

* patient admitted to PICU
* stay at PICU \> 24 hours
* informed consent by parent/legal representative

Exclusion criteria: none

Primary outcomes:
measure: Hospital-Acquired Infections (HAI) incidence density / 1,000 patient-days
timeFrame: Participants will be followed for the duration of hospital stay, an expected average of 6 days
Secondary outcomes:
measure: Microbial Burden measured on high-touch copper and non-copper surfaced objects
timeFrame: 1 year study duration
Other outcomes:
measure: Incidence of new events of colonization with selected pathogens per 1000 patient-days at risk
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 6 days
Locations:
city: Santiago
country: Chile
facility: Hospital Roberto del Rio
Study officials:
affiliation: Hospital Roberto del Rio
name: Bettina von Dessauer, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04455412: Laser Assisted ICSI; Has it Role Whatsoever?
Official title: Laser Assisted ICSI; Has it Role Whatsoever? Does it Affect the ICSI Outcome Positively?1
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: NA
Conditions: Laser Assistance to Improve ICSI Outcome
Keywords: Laser assisted-ICSI
Zona pellucida thinning
ICSI
embryo good quality rate
hatching rate
Lead sponsor: Royal Fertility Center, Egypt
Sponsor class: OTHER
First posted: 2020-07-02
Enrollment: 120
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 37
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: study divided into three interventions; Conventional ICSI (control group) was compared with LAD-ICSI (Study group 1) and LAT- ICSI (study group 2) in sibling oocytes. then Cases randomly selected for embryo transfer from each group
Primary purpose: TREATMENT

Brief summary: laser-assisted ICSI (LA-ICSI) was described to be a new method combining a less invasive ICSI technique with assisted hatching.This procedure is usually used for MII oocytes possessing oolemma breakage difficulties, but why not using it for even normal Oocytes?!. Especially because data indicated that in addition to an improved oocyte survival, this new approach increases the hatching rate in vitro. But since it is still debatable that such a small opening might impair the hatching process, so modified zona thinning technique was proposed for more embryo safety.

Detailed description: This study aims to compare the LA- ICSI by drilling a micro hole (LAD-ICSI) and modified LA-ICSI by zona pellucida thinning (LAT-ICSI) with conventional ICSI in order to effectively assess whether this approach can be applied routinely to improve ICSI outcome.

One arm study divided into three interventions; Conventional ICSI (control group) was compared with LAD-ICSI (Study group 1) and LAT- ICSI (study group 2) in sibling oocytes.

The rates of maturation, fertilization, Devision, Blastulation and good quality blastulation rates were assessed in the three groups

Cases were randomly selected for embryo transfer from the three groups,Then chemical pregnancy and clinical pregnancy rates were compared between the three groups.

Eligibility criteria: Inclusion Criteria:

* Patients aged from 20 years old to 37 years old
* good res-ponders
* gives more than 15 oocytes
* endometrial thickness more than 9 mm

Exclusion Criteria:

* poor res-ponders
* severe oligoasthinozoospermia of male partners
* testicular samples
* Poor quality oocytes

Primary outcomes:
measure: Clinical pregnancy rate
timeFrame: three-four weeks after embryo transfer
Secondary outcomes:
measure: Blastulation rate
timeFrame: 5 days later after ICSI procedure
measure: Hatching rate
timeFrame: 5 days later after ICSI procedure
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Royal Fertility Center
state: Daqahlia
Study officials:
References:
Clinical trial NCT06803212: Investigation of Dual-Task Exercise's Effect in Parkinson's Disease
Official title: Effect of Dual-Task Interference on Upper Extremity Motor Experience With Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson Disease
Lead sponsor: Karadeniz Technical University
Sponsor class: OTHER
First posted: 2025-01-31
Enrollment: 32
Sex: ALL
Minimum age (years): 50
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: This study was conducted to investigate the effects of dual-task training on upper extremity motor functions in patients with Parkinson's disease. A total of 32 patients participated in the study. Patients were divided into two groups by randomization. One group received only conventional physiotherapy applications, while the other group performed dual-task exercises in addition. Dual-task exercises were performed while conventional treatment was applied. The treatment program was applied as 60x5x6 min/day/week.

Conventional treatment was determined according to the individual needs of the patients, including the lower and upper extremities. Dual-task interventions included performing such as counting backward, word recall, and reading words backward.

Assessments were repeated twice: Baseline and after a 30-session. "Demographic Information", "Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)", "Box and Block Test" and "Parkinson Disease Questionnaire (PDQ-39) were used as assessment tools.


Eligibility criteria: Inclusion Criteria:

* Patients aged 50-85 years with a diagnosis of Stage 1-3 Parkinson's disease, based on the Hoehn \& Yahr Scale
* Patients had to have no issues with performing basic mathematical operations, - A Mini-Mental State Examination (MMSE) score above 24 points,
* Regular medication use for at least 4 weeks (for patients who were prescribed medical treatment),
* No comorbid neurological, neuromuscular, or orthopedic diseases

Exclusion Criteria:

* Patients with vision or hearing impairments,
* Moderate-to-severe fluctuations in tremor or dyskinesia,
* Having deep brain stimulator implants, or sensory loss in the upper extremities.

Primary outcomes:
measure: Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS):
timeFrame: Baseline of the study
measure: Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS):
timeFrame: End of the 30th physiotherapy session
Secondary outcomes:
measure: Box Block Test (BBT)
timeFrame: Baseline of the study
measure: Box Block Test (BBT)
timeFrame: End of the 30th physiotherapy session
measure: Parkinson's Disease Questionnaire - 39 (PDQ-39)
timeFrame: Baseline of the study
measure: Parkinson's Disease Questionnaire - 39 (PDQ-39)
timeFrame: End of the 30th physiotherapy session
measure: Demographic Data Form
timeFrame: Baseline of the study
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: İstanbul Tıp Merkezi
Study officials:
References:
Clinical trial NCT06883812: Continuous Glucose Monitoring in Prediabetes with Health Education Videos
Official title: Continuous Glucose Monitoring in Prediabetes with Health Education Videos
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Prediabetes
Keywords: Prediabetes
Glucose control
Feedback
Health education
Artificial intelligence
Behavioral analysis
Lead sponsor: University of Southern California
Sponsor class: OTHER
Collaborators: name: National Institute on Minority Health and Health Disparities (NIMHD)
First posted: 2025-03-19
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SEQUENTIAL
Intervention model description: An AB sequential condition design with CGM automated continuous glucose recording with glucose level masked and unmasked phases.
Primary purpose: PREVENTION

Brief summary: The objective of this project is to deliver a behavior health education video series that combines wearable continuous glucose monitoring (CGM) with smartphone feedback and video clips generated by artificial intelligence (AI) software to improve glycemic control among individuals with prediabetes. The goal is to prevent transition to type 2 diabetes and advanced metabolic complications.

Detailed description: A health education video series, ¡Mi Control!, led by community health workers known as Promotores de Salud (PdS), will be integrated with continuous glucose monitoring (CGM) to support self-monitoring of glucose levels and excursions. Study G2 is a Phase 0 feasibility study enrolling 30 Spanish- and/or English-speaking PdS who test positive for prediabetes via a finger-prick A1c% screening. Participants will wear CGM devices for 20 days, with glucose data masked for the first 10 days and unmasked for the next 10 days. During the unmasked phase, participants will receive daily health education videos on their smartphones. The study will compare the duration of glucose excursions between the masked and unmasked phases to assess the impact of CGM feedback and health education on glucose regulation.

Eligibility criteria: Inclusion Criteria:

Pre-diabetes determined by finger prick A1c% Willingness to wear a CGM sensor Community health worker

Exclusion Criteria:

Currently pregnant Diagnosed with any disorder likely interfering with blood glucose levels Influential medical disorder or event affecting ability to participate in the study Incompatible smartphone device not pairing with the Dexcom CGM system

Primary outcomes:
measure: Glucose levels
timeFrame: Maximum of 20 days of continuous wear
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Southern California Center for Latino Health SCCLH
state: California
Study officials:
affiliation: University of Southern California Keck School of Medicine
name: David S Black, PhD MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06109012: Multiple Disseminated Hydatidosis With Rare Locations
Official title: Multiple Disseminated Hydatidosis With Rare Locations: Mediastinal, Pancreatic and Pelvic: Case Report
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Echinococcus Infections
Keywords: echinococcus
serology
multiple locations
Lead sponsor: Faculty Of Medicine And Pharmacy, Casablanca
Sponsor class: OTHER
First posted: 2023-10-31
Enrollment: 1
Sex: MALE
Minimum age (years): 44
Maximum age (years): 44
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This is a descriptive study of a single patient with the particularity of having exceptional locations of hydatidosis.

Brief summary: Hydatid disease is an anthropozoonosis due to the development of the larval form of Echinococcus granulosus in the human body, which constitutes a 'dead-end' host. It's a common parasitosis in North African countries and constitutes a public health problem in Morocco. The liver and lung are the most affected while the mediastinum, pancreas and pelvis are rarely affected. We report the case of a 40-year-old patient operated 15 years ago for cerebral and cervical hydatid cysts and who was hospitalized for generalized mucocutaneous jaundice. On exploration, we discover the presence of disseminated abdominal hydatidosis with association of 3 rare locations: mediastinal, pancreatic and pelvic. Indirect diagnostic tests were positive: indirect hemagglutination (IHA) and Elisa. The Western blot test also showed the presence of specific bands, thus making it possible to retain the diagnosis of hydatidosis.

The hydatid cyst with mediastinal, pancreatic and pelvic location is rare and their association is very exceptional. It is essential to evoke the hydatid origin of any cystic lesion in a patient staying in an endemic area.


Eligibility criteria: Inclusion Criteria:

* none

Exclusion Criteria:

* none

Primary outcomes:
measure: THE PATIENT DIED due to probably anaphylactic shock
timeFrame: 1 mounth
Secondary outcomes:
Other outcomes:
Locations:
city: Casablanca
country: Morocco
facility: FMPC
state: Anfa
Study officials:
References:
Clinical trial NCT01564212: Quantitative Heat Loss With Laminar Air Flow
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: heat loss
laminar airflow
operating rooms
Lead sponsor: The Cleveland Clinic
Sponsor class: OTHER
First posted: 2012-03-27
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: With approval of the IRB at the Cleveland Clinic and written informed consent, the investigators propose to study up to 20 healthy volunteers in the protocol below as this will allow for drop-outs. As the investigators believe that 10 volunteers will provide sufficient power to detect clinically-meaningful differences between laminar air flow treatments.

The study has been designed to find out whether heat loss increases significantly in laminar air flow operating rooms. Furthermore the investigators will find out whether active warming minimizes this heat loss. Increased heat loss increases the amount of perioperative hypothermia. It has been shown that perioperative hypothermia is associated with severe complications such as an increased incidence of surgical wound infections. On the other hand laminar air flow is explicitly used to decrease air-borne infections. Our study results will help to optimize thermal management of orthopedic patients.


Eligibility criteria: Inclusion Criteria:

* 18 to 45 years of age
* Healthy male and female volunteers
* ASA physical status I
* Capable and willing to provide written informed consent

Primary outcomes:
measure: heat loss
timeFrame: 20 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
Study officials:
affiliation: The Cleveland Clinic
name: Andrea Kurz, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06136312: Clinical Investigation of the Multi4 System
Official title: A Clinical Investigation to Confirm Performance and Safety of the Multi4 System in Patients With Suspected Recurrent Bladder Cancer Lesions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bladder Cancer
Lead sponsor: Multi4 Medical Ab
Sponsor class: INDUSTRY
Collaborators: name: Key2Compliance
First posted: 2023-11-18
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A Clinical Investigation to Confirm Performance and Safety of the Multi4 System in Patients with Suspected Recurrent Bladder Cancer Lesions

Detailed description: The overall purpose of this study is to confirm performance and safety of Multi4 Medical Device System when used as intended: to cauterize, remove, and automatically collect multiple tissue samples through the working channel of an endoscope.

The safety profile will be documented by collecting data on frequency and severity of complications, AEs such as bleeding and perforations.

Eligibility criteria: Inclusion Criteria:

* Previous bladder cancer Ta/T1 G1-3
* Recurrence of urinary superficial/ non-muscle-invasive bladder cancer visible at cystoscopy, estimated size \< 10 mm
* Willingness and ability to provide informed consent
* Age ≥18 years

Exclusion Criteria:

* Implantable Cardioverter Defibrillator (ICD) that cannot be inactivated
* Current/ongoing untreated urinary tract infection
* Pregnancy or breastfeeding
* Be identified by the Investigator as inappropriate from a medical or compliance perspective to participate in this investigation

Primary outcomes:
measure: Evaluable biopsies
timeFrame: At procedure
Secondary outcomes:
measure: Number of participants with treatment-related adverse events
timeFrame: One week
measure: Number of patients with complete procedures performed
timeFrame: At procedure
measure: Patient-reported treatment-related pain (numeric rating scale)
timeFrame: At procedure
measure: Quality of life (EQ-5D-5L)
timeFrame: At procedure and after 1 week
measure: Time to perform procedure
timeFrame: At procedure
measure: Time for patient surveillance
timeFrame: At procedure
measure: Self reported satisfaction with procedure
timeFrame: One week
measure: Operator-reported ease of use
timeFrame: At procedure
measure: Cost effectiveness
timeFrame: At procedure
Other outcomes:
Locations:
city: Gothenburg
country: Sweden
facility: Sahlgrenska University Hospital
Study officials:
affiliation: Sahlgrenska University Hospital
name: Henrik Kjölhede, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03172312: Clinical Utility of Intraoperative Parathyroid Scores System in Thyroidectomy
Official title: Clinical Utility of Intraoperative Parathyroid Scores System in Thyroidectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intraoperative Parathyroid Scores System
Keywords: Intraoperative Parathyroid Scores System
total thyroidectomy
thyroid cancer
hypoparathyroidism
prediction
Lead sponsor: Fujian Medical University
Sponsor class: OTHER
First posted: 2017-06-01
Enrollment: 500
Sex: ALL
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who need thyroid surgery

Brief summary: Ready to establish the Intraoperative Parathyroid Scores System (IPSS) for thyroidectomy and study the clinical value of Intraoperative Parathyroid Scores System for thyroidectomy.

Detailed description: IPSS includes transplantation Parathyroid Scores and in situ Parathyroid Scores, the investigators will establish the Intraoperative Parathyroid Scores System by parathyroid size and Blood supply, and recording IPSS, according to certain rules. Parathyroid hormone and calcium were test in d0, d1, d14, d60 post operation. The correlation between Intraoperative Parathyroid Scores and PTH calcium were calculated, and ROC curve and logistic regression were tested for the prediction value.

Eligibility criteria: Inclusion Criteria:

1. postoperative pathology confirmed as thyroid papillary carcinoma;
2. for the first time to undergo thyroid surgery, no history of neck surgery and external radiotherapy;
3. preoperative serum calcium, parathyroid hormone levels were normal;
4. intraoperative and postoperative clinical data integrity, standardized follow-up patients;
5. parathyroid is a tumor violation.

Exclusion Criteria:

1. serious underlying disease;
2. age greater than 60 years of age or combined with arteriosclerotic disease;
3. patients with postoperative loss;
4. patients with parathyroid disease.

Primary outcomes:
measure: transplantation Parathyroid Scores correlated with transplanted parathyroid function
timeFrame: 2014-2016
measure: the value of IPSS and in situ Parathyroid Scores
timeFrame: 2014-2016
measure: predicted function of IPSS
timeFrame: 2014-2016
measure: value of IPSS in low PTH patients
timeFrame: 2014-2016
Secondary outcomes:
measure: value of IPSS for Surgeon and patient
timeFrame: 2014-2016
Other outcomes:
Locations:
city: Fuzhou
country: China
facility: Wen-xin ZHAO
state: Fujian
Study officials:
References:
Clinical trial NCT02595112: Study of Staphylococcus Aureus Colonization of the Posterior Nasal Cavity in Patients Undergoing Otorhinolaryngologic Surgery
Official title: Study of Staphylococcus Aureus Colonization of the Posterior Nasal Cavity in Patients Undergoing Otorhinolaryngologic Surgery. A Monocentric Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Staphylococcal Infections
Keywords: staphylococcal infections
nasal carriage
nasal cavity
Staphylococcus aureus
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2015-11-03
Enrollment: 95
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: Staphylococcus aureus nasal carriage is a major risk factor of infection with this bacterium. Staphylococcus aureus colonization of the posterior nasal cavity is still misunderstood. This study is aimed at evaluating the relationship between Staphylococcus aureus strains colonizing the vestibulum nasi, the sphenoethmoidal recess and the nasopharynx.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing otorhinolaryngologic surgery, unknown Staphylococcus aureus carriage state
* Patient affiliated to French Social Security
* Written consent

Exclusion Criteria:

* Antibiotherapy or infectious episode during the month prior enrollment
* coagulation disorder
* neoplasia of the nasal cavity

Primary outcomes:
measure: number of patients with staphylococcus aureus carriage in the posterior nasal cavity
timeFrame: Day 1
Secondary outcomes:
measure: number of patients with staphylococcus aureus carriage in the vestibulum nasi
timeFrame: Day 1
Other outcomes:
Locations:
city: Saint-Etienne
country: France
facility: CHU Saint-Etienne
Study officials:
affiliation: CHU SAINT-ETIENNE
name: Paul Verhoeven
role: PRINCIPAL_INVESTIGATOR
References: