Clinical trial NCT05552976: A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
Official title: A Phase 3, Two-stage, Randomized, Multicenter, Open-label Study Comparing Mezigdomide (CC-92480/BMS-986348), Carfilzomib, and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-2
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Relapsed or Refractory Multiple Myeloma
Keywords: BMS-986348
CC-92480
Carfilzomib
Dexamethasone
Multiple Myeloma
Mezigdomide
Lead sponsor: Bristol-Myers Squibb
Sponsor class: INDUSTRY
First posted: 2022-09-23
Enrollment: 525
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This is a two-stage inferentially seamless design.
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to compare Mezigdomide (CC-92480/BMS-986348) with carfilzomib and dexamethasone (MeziKD) against carfilzomib and dexamethasone (Kd) in the treatment of RRMM: SUCCESSOR-2.


Eligibility criteria: Inclusion Criteria

- Participant has documented diagnosis of multiple myeloma and measurable disease, defined as any of the following:.

i) Myeloma-protein (M-protein) ≥ 0.5 grams/deciliter (g/dL) by serum protein electrophoresis (sPEP), or.

ii) M-protein ≥ 200 milligrams (mg)/24-hour urine collection by urine protein electrophoresis (uPEP) or,.

iii) For participants without measurable disease in sPEP or uPEP: serum free light chain levels \> 100 mg/liter (L) (10 mg/dL) involved light chain and an abnormal κ/λ free light chain ratio.

* Participant has received at least one prior line of anti-myeloma therapy. Note: One line can contain several phases (e.g., induction, \[with or without\] hematopoietic stem cell transplant, (with or without) consolidation, and/or \[with or without\] maintenance therapy).
* Participant must have received prior treatment with lenalidomide and at least 2 cycles of an anti-CD38 monoclonal antibody (mAb) (participants who were intolerant of an anti-CD38 mAb and received \< 2 cycles are still eligible).
* Participant achieved minimal response or better to at least 1 prior anti-myeloma therapy.
* Participant must have documented disease progression during or after their last antimyeloma regimen.

Exclusion Criteria

* Participant who has had prior treatment with mezigdomide or carfilzomib.
* Participant has previously received allogeneic stem cell transplant at any time or received autologous stem cell transplant within 12 weeks of initiating study treatment.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcomes:
measure: Progression-free Survival (PFS)
timeFrame: Up to approximately 5 years
Secondary outcomes:
measure: Recommended Mezigdomide Dose
timeFrame: Up to 12 months
measure: Plasma concentrations of Mezigdomide in Combination with Carfilzomib and Dexamethasone
timeFrame: Up to 176 days
measure: Overall Survival (OS)
timeFrame: Up to approximately 5 years
measure: Overall Response (OR)
timeFrame: Up to approximately 5 years
measure: Rate Of Very Good Partial Response (VGPR) Or Better (VGPRR)
timeFrame: Up to approximately 5 years
measure: Complete Response (CR) Or Better (CRR)
timeFrame: Up to approximately 5 years
measure: Time To Response (TTR)
timeFrame: Up to approximately 5 years
measure: Duration Of Response (DOR)
timeFrame: Up to approximately 5 years
measure: Time To Progression (TTP)
timeFrame: Up to approximately 5 years
measure: Time To Next Treatment (TTNT)
timeFrame: Up to approximately 5 years
measure: Progression-free Survival 2 (PFS-2)
timeFrame: Up to approximately 5 years
measure: Minimal Residual Disease (MRD) Negativity Rate
timeFrame: Up to approximately 5 years
measure: Number Of Participants With Adverse Events (AEs)
timeFrame: Up to approximately 5 years
measure: Change From Baseline in the European Organization for Research and Treatment of Cancer - Quality of Life C30 Questionnaire (EORTC QLQ-C30)
timeFrame: Up to approximately 5 years
measure: Change From Baseline in the European Quality of Life Multiple Myeloma Module (EORTC QLQ-MY20)
timeFrame: Up to approximately 5 years
Other outcomes:
Locations:
city: Mobile
country: United States
facility: USA Mitchell Cancer Institute
state: Alabama
city: Cerritos
country: United States
facility: TOI Clinical Research
state: California
city: Irvine
country: United States
facility: Kaiser Permanente - Irvine
state: California
city: Los Angeles
country: United States
facility: Los Angeles Hematology Oncology Medical Group
state: California
city: Santa Rosa
country: United States
facility: Sutter Santa Rosa
state: California
city: Stockton
country: United States
facility: Stockton Hematology Oncology Group
state: California
city: Newark
country: United States
facility: Local Institution - 0279
state: Delaware
city: Fort Myers
country: United States
facility: Florida Cancer Specialists - South
state: Florida
city: Saint Petersburg
country: United States
facility: Florida Cancer Specialists - North
state: Florida
city: West Palm Beach
country: United States
facility: Florida Cancer Specialists - East
state: Florida
city: Atlanta
country: United States
facility: Emory University School of Medicine- Grady Campus
state: Georgia
city: Atlanta
country: United States
facility: Winship Cancer Institute, Emory University
state: Georgia
city: Boise
country: United States
facility: Saint Alphonsus Regional Medical Center
state: Idaho
city: Annapolis
country: United States
facility: Anne Arundel Medical Center
state: Maryland
city: Boston
country: United States
facility: Dana-Farber Cancer Institute
state: Massachusetts
city: Minneapolis
country: United States
facility: Minnesota Oncology Hematology, P.A.
state: Minnesota
city: Little Silver
country: United States
facility: Regional Cancer Care Associates
state: New Jersey
city: Bronx
country: United States
facility: Montefiore Medical Center
state: New York
city: Chapel Hill
country: United States
facility: University of North Carolina Medical Center
state: North Carolina
city: Cleveland
country: United States
facility: University Hospitals Cleveland Medical Center
state: Ohio
city: Columbus
country: United States
facility: Riverside Methodist Hospital
state: Ohio
city: Providence
country: United States
facility: Lifespan Cancer Institute
state: Rhode Island
city: Charleston
country: United States
facility: Charleston Oncology, P.A.
state: South Carolina
city: Greer
country: United States
facility: Gibbs Cancer Center & Research Institute
state: South Carolina
city: Chattanooga
country: United States
facility: Tennessee Oncology Chattanooga
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology
state: Tennessee
city: Fort Worth
country: United States
facility: John Peter Smith Hospital
state: Texas
city: Houston
country: United States
facility: Kelsey-Seybold Clinic
state: Texas
city: Houston
country: United States
facility: Houston Methodist Hospital
state: Texas
city: Temple
country: United States
facility: Local Institution - 0195
state: Texas
city: Norfolk
country: United States
facility: Virginia Oncology Associates
state: Virginia
city: Roanoke
country: United States
facility: Blue Ridge Cancer Care
state: Virginia
city: Tacoma
country: United States
facility: Northwest Medical Specialties PLLC
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists, P.C.
state: Washington
city: Morgantown
country: United States
facility: WVU Cancer Institute
state: West Virginia
city: Marshfield
country: United States
facility: Marshfield Medical Center - Marshfield
state: Wisconsin
city: Ciudad Autónoma de Buenos Aires
country: Argentina
facility: Instituto Alexander Fleming
state: Buenos Aires
city: ABB
country: Argentina
facility: Hospital Italiano de Buenos Aires
state: Ciudad Autónoma De Buenos Aires
city: Rosario
country: Argentina
facility: Fundacion Estudios Clinicos
state: Santa Fe
city: San Miguel de Tucumán
country: Argentina
facility: C.I.C.E. 9 de Julio
state: Tucumán
city: Buenos Aires
country: Argentina
facility: Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)
city: Córdoba
country: Argentina
facility: Sanatorio Allende - Nueva Córdoba
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital
state: New South Wales
city: Gosford
country: Australia
facility: Gosford Hospital
state: New South Wales
city: Port Macquarie
country: Australia
facility: Port Macquarie - Mid North Coast Cancer Institute
state: New South Wales
city: St Leonards
country: Australia
facility: Royal North Shore Hospital
state: New South Wales
city: Sydney
country: Australia
facility: St Vincent's Hospital
state: New South Wales
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
state: South Australia
city: Hobart
country: Australia
facility: Local Institution - 0229
state: Tasmania
city: Bendigo
country: Australia
facility: Bendigo Health Care Group
state: Victoria
city: East Melbourne
country: Australia
facility: Epworth Freemasons
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Health
state: Victoria
city: Melbourne
country: Australia
facility: St Vincent's Hospital
state: Victoria
city: Vienna
country: Austria
facility: Krankenhaus der Barmherzigen Schwestern Wien
state: Wien
city: Linz
country: Austria
facility: Ordensklinikum Linz GmbH Elisabethinen
city: Wien
country: Austria
facility: Medizinische Universität Wien
city: Wien
country: Austria
facility: Local Institution - 0119
city: Salvador
country: Brazil
facility: Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
state: Bahia
city: Porto Alegre
country: Brazil
facility: Hospital do Câncer Mãe de Deus
state: Rio Grande Do Sul
city: Sao Paulo
country: Brazil
facility: A. C. Camargo Cancer Center
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: Instituto de Educação, Pesquisa e Gestão em Saúde
city: Rio de Janeiro
country: Brazil
facility: Local Institution - 0086
city: São Paulo
country: Brazil
facility: Clínica Médica São Germano S/S Ltda
city: Plovdiv
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD
city: Sofia
country: Bulgaria
facility: Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
city: Sofia
country: Bulgaria
facility: UMHAT 'Sveti Ivan Rilsky'
city: Halifax
country: Canada
facility: QEII Health Sciences Centre - Victoria General Site
state: Nova Scotia
city: London
country: Canada
facility: Victoria Hospital & Children's Hospital - London Health Sciences Centre
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Cancer Centre
state: Ontario
city: Montreal
country: Canada
facility: Local Institution - 0186
state: Quebec
city: Hefei
country: China
facility: Local Institution - 0318
state: Anhui
city: Beijing City
country: China
facility: Beijing Chaoyang Hospital, Capital Medical University
state: Beijing
city: Beijing
country: China
facility: Beijing Chaoyang Hospital, Capital Medical University
state: Beijing
city: Beijing
country: China
facility: Beijing Peking Union Medical College Hospital
state: Beijing
city: Fuzhou
country: China
facility: Fujian Medical University Union Hospital-1 Bingfanglou
state: Fujian
city: Guangzhou
country: China
facility: Sun Yat-sen University Cancer Center
state: Guangdong
city: Guangzhou
country: China
facility: Local Institution - 0315
state: Guangdong
city: Zhengzhou
country: China
facility: Henan Cancer Hospital
state: Henan
city: Wuhan
country: China
facility: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
state: Hubei
city: Wuhan
country: China
facility: Tongji Hospital Tongji Medical,Science & Technology
state: Hubei
city: Changsha
country: China
facility: Hunan Cancer Hospital
state: Hunan
city: Changsha
country: China
facility: The Third Xiangya Hospital of Central South University
state: Hunan
city: Nanjing
country: China
facility: Zhongda Hospital Southeast University
state: Jiangsu
city: Nantong
country: China
facility: Affiliated Hospital of Nantong University
state: Jiangsu
city: Suzhou
country: China
facility: The First Affiliated Hospital of Soochow University
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi People's Hospital
state: Jiangsu
city: Nanchang
country: China
facility: The Second Affiliated Hospital of Nanchang University
state: Jiangxi
city: Changchun
country: China
facility: The First Hospital of Jilin University
state: Jilin
city: Shenyang
country: China
facility: The First Hospital of China Medical University
state: Liaoning
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
state: Liaoning
city: Xi'an
country: China
facility: Local Institution - 0060
state: Shaanxi
city: Jinan
country: China
facility: Qilu Hospital of Shandong University (Qingdao)
state: Shandong
city: Shanghai
country: China
facility: Ruijin Hospital Shanghai Jiaotong University School of Medicine
state: Shanghai
city: Shanghai
country: China
facility: Tongji University - Shanghai Fourth People's Hospital
state: Shanghai
city: Tianjing
country: China
facility: Tianjin Medical University Cancer Institute And Hospital
state: Tianjin
city: Kunming
country: China
facility: Local Institution - 0058
state: Yunnan
city: Hangzhou
country: China
facility: The first Affiliated Hospital, Zhejiang University School of Medicine
state: Zhejiang
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University
state: Zhejiang
city: Taiyuan
country: China
facility: Shanxi Bethune Hospital
city: Medellin
country: Colombia
facility: Hospital Pablo Tobon Uribe
state: Antioquia
city: Valledupar
country: Colombia
facility: Sociedad De Oncologia Y Hematologia Del Cesar
state: Cesar
city: Bogota
country: Colombia
facility: Instituto Nacional De Cancerologia
state: Cundinamarca
city: Piedecuesta
country: Colombia
facility: Fundación Cardiovascular de Colombia
state: Santander
city: Cali
country: Colombia
facility: IPS Centro Médico Julián Coronel S.A.S
city: Aarhus
country: Denmark
facility: Aarhus Universitetshospital, Skejby
state: Midtjylland
city: Roskilde
country: Denmark
facility: Roskilde Sygehus
state: Sjælland
city: Odense
country: Denmark
facility: Odense Universitetshospital
state: Syddanmark
city: Vejle
country: Denmark
facility: Vejle Sygehus
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm
state: Baden-Wurttemberg
city: Munich
country: Germany
facility: Haematologie und Onkologie Muenchen-Pasing
state: Bayern
city: Nürnberg
country: Germany
facility: Klinikum Nuernberg Nord, Urologische Klinik
state: Bayern
city: Hannover
country: Germany
facility: Praxis Onkologie am Raschplatz
state: Niedersachsen
city: Dortmund
country: Germany
facility: GEFOS Gesellschaft f. onkologische Studien
state: Nordrhein-Westfalen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel
state: Schleswig-Holstein
city: Jena
country: Germany
facility: Universitätsklinikum Jena
state: Thüringen
city: Berlin
country: Germany
facility: Charite Universitätsmedizin Berlin Campus Benjamin Franklin
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus Dresden
city: Düsseldorf
country: Germany
facility: Marien Hospital Düsseldorf
city: Heidelberg
country: Germany
facility: Universitaetsklinikum Heidelberg
city: Köln
country: Germany
facility: Local Institution - 0102
city: Leipzig
country: Germany
facility: Universitätsklinikum Leipzig
city: Wuerzburg
country: Germany
facility: Universitaetsklinikum Wuerzburg
city: Patras
country: Greece
facility: University Hospital of Patras
state: Achaḯa
city: Athens
country: Greece
facility: Alexandra General Hospital of Athens
state: Attikí
city: Thessaloniki
country: Greece
facility: G. Papanikolaou General Hospital
state: Thessaloníki
city: Hksar
country: Hong Kong
facility: Queen Mary Hospital
city: Pécs
country: Hungary
facility: Pécsi Tudományegyetem Klinikai Központ
state: Baranya
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont
state: Hajdú-Bihar
city: Nyiregyhaza
country: Hungary
facility: Szabolcs Szatmár Bereg Vármegyei Oktatókórház
state: Szabolcs-Szatmár-Bereg
city: Budapest
country: Hungary
facility: Semmelweis Egyetem
city: Budapest
country: Hungary
facility: Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
city: New Delhi
country: India
facility: Rajiv Gandhi Cancer Institute And Research Centre
state: Delhi
city: Gurgaon
country: India
facility: Medanta-The Medicity
state: Haryana
city: Bengaluru
country: India
facility: HCG-Bangalore
state: Karnataka
city: Mumbai
country: India
facility: Tata Memorial Hospital
state: Maharashtra
city: Thane
country: India
facility: Mumbai Oncocare Centre - Thane
state: Maharashtra
city: Mohali
country: India
facility: Max Super Specialty Hospital - Mohali
state: Punjab
city: Chennai
country: India
facility: Local Institution - 0174
state: Tamil Nadu
city: Hyderabad
country: India
facility: Apollo Institute of Medical Sciences and Research
state: Telangana
city: Hyderabad
country: India
facility: Kamineni Hospitals - L.B.Nagar
state: Telangana
city: Hyderabad
country: India
facility: Yashoda Hospitals - Hitech City
state: Telangana
city: Chandigarh
country: India
facility: Postgraduate Institute of Medical Education & Research
city: Holon
country: Israel
facility: Edith Wolfson Medical Center
state: HaMerkaz
city: Zerifin
country: Israel
facility: Yitzhak Shamir Medical Center
state: HaMerkaz
city: Jerusalem
country: Israel
facility: Hadassah Medical Center
city: Meldola
country: Italy
facility: IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
state: Emilia-Romagna
city: Milano
country: Italy
facility: Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
state: Lombardia
city: Rozzano
country: Italy
facility: Humanitas
state: Milano
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
city: Catanzaro
country: Italy
facility: Azienda Ospedaliera "Pugliese Ciaccio"
city: Lecce
country: Italy
facility: Ospedale Vito Fazzi
city: Pisa
country: Italy
facility: Azienda Ospedaliera Universitaria Pisana
city: Udine
country: Italy
facility: P.O. "S. Maria della Misericordia" Azienda Sanitaria Universitaria Friuli Centrale
city: Nagoya
country: Japan
facility: Nagoya City University Hospital
state: Aichi
city: Kashiwa
country: Japan
facility: National Cancer Center Hospital East
state: Chiba
city: Kitakyushu-shi
country: Japan
facility: Japan Community Healthcare Organization Kyushu Hospital
state: Fukuoka
city: Sapporo
country: Japan
facility: National Hospital Organization Hokkaido Cancer Center
state: Hokkaido
city: Higashiibaraki
country: Japan
facility: Mito Medical Center
state: Ibaraki
city: Kanazawa
country: Japan
facility: Kanazawa University Hospital
state: Ishikawa
city: Shiwa-gun Yahaba-cho
country: Japan
facility: Iwate Medical University Hospital
state: Iwate
city: Kamakura
country: Japan
facility: Shonan Kamakura General Hospital
state: Kanagawa
city: Koshigaya
country: Japan
facility: Dokkyo Medical University Saitama Medical Center
state: Saitama
city: Itabashiku
country: Japan
facility: Nihon University Itabashi Hospital
state: Tokyo
city: Koto
country: Japan
facility: Japanese Foundation for Cancer Research
state: Tokyo
city: Chuo
country: Japan
facility: University of Yamanashi Hospital
state: Yamanashi
city: Chiba
country: Japan
facility: Chiba University Hospital
city: Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Medical Center
city: Fukuoka
country: Japan
facility: Japanese Red Cross Fukuoka Hospital
city: Kumamoto
country: Japan
facility: Kumamoto University
city: Kyoto
country: Japan
facility: University Hospital,Kyoto Prefectural University of Medicine
city: Nagasaki
country: Japan
facility: The Japanese Red Cross Nagasaki Genbaku Hospital
city: Okayama
country: Japan
facility: National Hospital Organization Okayama Medical Center
city: Osaka
country: Japan
facility: Osaka Metropolitan University Hospital
city: Tokyo
country: Japan
facility: The Jikei University Hospital
city: Tokyo
country: Japan
facility: Japanese Red Cross Medical Center
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: The Catholic Univ. of Korea Seoul St. Mary's Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis, locatie Breda Molengracht
state: Noord-Brabant
city: Enschede
country: Netherlands
facility: Medisch Spectrum Twente
city: Bergen
country: Norway
facility: Haukeland Universitetssjukehus
state: Hordaland
city: Stavanger
country: Norway
facility: Stavanger Universitetssykehus
state: Rogaland
city: Oslo
country: Norway
facility: Oslo Universitetssykehus Ullevål
city: San Juan
country: Puerto Rico
facility: Pan American Center for Oncology Trials - Ciudadela
city: Bucuresti
country: Romania
facility: Fundeni Clinical Institute
state: București
city: Timișoara
country: Romania
facility: Local Institution - 0290
state: Timiș
city: Brasov
country: Romania
facility: Sc Onco Card Srl
city: București
country: Romania
facility: Affidea Fundeni
city: București
country: Romania
facility: Spitalul Clinic Colțea
city: Sibiu
country: Romania
facility: Spitalul Clinic Județean de Urgență Sibiu
city: Singapore
country: Singapore
facility: National University Hospital
state: Central Singapore
city: Singapore
country: Singapore
facility: Singapore General Hospital
state: Central Singapore
city: Badalona
country: Spain
facility: Institut Catalan d Oncologia (ICO) - Badalona
state: Barcelona [Barcelona]
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron
state: Barcelona [Barcelona]
city: L'Hospitalet Del Llobregat
country: Spain
facility: Institut Català d'Oncologia - L'Hospitalet
state: Barcelona [Barcelona]
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañon
state: Madrid, Comunidad De
city: Majadahonda
country: Spain
facility: Local Institution - 0108
state: Madrid, Comunidad De
city: San Cristobal de La laguna
country: Spain
facility: Hospital Universitario de Canarias
state: Santa Cruz De Tenerife
city: San Cristobal de La laguna
country: Spain
facility: Local Institution - 0192
state: Santa Cruz De Tenerife
city: Valencia
country: Spain
facility: Hospital Clinico de Valencia
state: Valenciana, Comunitat
city: Granada
country: Spain
facility: Hospital Universitario Virgen Nieves
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Málaga
country: Spain
facility: H.R.U Málaga - Hospital General
city: Chiayi City
country: Taiwan
facility: Chang Gung Memorial Hospital- Chiayi
state: Chiayi
city: Kaohsiung Niao Sung Dist
country: Taiwan
facility: Chang Gung Memorial Hospital at Kaohsiung
state: Kaohsiung
city: Kaohsiung
country: Taiwan
facility: E-Da Cancer Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital
city: Taipei
country: Taiwan
facility: Local Institution - 0149
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Plymouth
country: United Kingdom
facility: Derriford Hospital
state: Devon
city: Cringleford
country: United Kingdom
facility: Norfolk and Norwich University Hospitals NHS Foundation Trust
state: England
city: Glasgow
country: United Kingdom
facility: The Beatson West of Scotland Cancer Centre
state: Glasgow City
city: Birmingham
country: United Kingdom
facility: Local Institution - 0039
city: Birmingham
country: United Kingdom
facility: Heartlands Hospital
city: Leeds
country: United Kingdom
facility: St James's University Hospital
city: Taunton
country: United Kingdom
facility: Musgrove Park Hospital
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References: