louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03033173: Ratio of the Cross Sectional Area of Median Nerve to Ulnar Nerve in Diagnosing Carpal Tunnel Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: An Innovative Diagnostic Method for Carpal Tunnel Syndrome
Lead sponsor: Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Sponsor class: OTHER
First posted: 2017-01-26
Enrollment: 74
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: CTS patients were recruited from the Physical Medicine and Rehabilitation Department of Taipei Tzu Chi hospital.

Healthy subjects were recruited from hospital staff, health volunteers and their friends.

Brief summary: An innovative diagnostic ultrasound method for carpal tunnel syndrome was proposed and compared between carpal tunnel syndrome patients and healthy volunteers.


Eligibility criteria: Inclusion Criteria:

* CTS patients were required to have subjective symptoms of numbness, tingling pain, or dysesthesia over the median nerve innervated area of the involved hand.
* Patients should have positive response in either Tinel's test or Phalen's test during physical examination
* Evidence of median neuropathy at wrist level in NCS.
* Control subjects should have neither symptoms nor signs of CTS along with no abnormal findings in electrodiagnostic study of the median nerve and the ulnar nerve across the wrist joint.

Exclusion Criteria:

* Age younger than 20 years old
* Electrodiagnostic evidence of ulnar neuropathy at the wrist level
* Previous trauma or surgery history of hand
* Medical history of hypothyroidism, diabetes mellitus, uremia, rheumatoid arthritis, amyloidosis, and acromegaly
* Pregnancy

Primary outcomes:
measure: Sonographical findings between hands with CTS and healthy hands
timeFrame: Within one week after ultrasound examination
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Chang YW, Hsieh TC, Tzeng IS, Chiu V, Huang PJ, Horng YS. Ratio and difference of the cross-sectional area of median nerve to ulnar nerve in diagnosing carpal tunnel syndrome: a case control study. BMC Med Imaging. 2019 Jul 4;19(1):52. doi: 10.1186/s12880-019-0351-3.
Clinical trial NCT00886873: Mifepristone 10 or 5 mg for 6 Months to Treat Uterine Fibroids
Official title: Mifepristone 5 mg Versus 10 mg During 6 Months for the Treatment of Uterine Leiomyomata. A Randomized, Double Blinded Clinical Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Uterine Fibroids
Keywords: Uterine fibroids
Mifepristone
Antiprogestins
Lead sponsor: Mediterranea Medica S. L.
Sponsor class: OTHER
First posted: 2009-04-23
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objectives of this study are to estimate the efficacy and safety of the daily administration for 6 months of 5 mg versus 10 mg. A 6 month follow-up of subjects is carried out to estimate how the effects of mifepristone are kept in time.

The hypothesis of this study is that both mifepristone doses reduce the volume of the myoma up to 50% in six months treatment.

Detailed description: Women, in fertile age or premenopausal status, presenting symptomatic myomaswere randomly assigned to receive 5 or 10 mg of mifepristone for six months.

The decreasing in the prevalence of symptoms attributable to myomas is an important goal to achieve under both treatments. Another goal is to maintain for more than 6 months the benefits of the treatment with mifepristone.

Eligibility criteria: Inclusion Criteria:

* Symptomatic uterine fibroids
* Reproductive age or premenopausal
* Accepting the use of non hormonal contraception
* Conformity in keeping a monthly log of all episodes of vaginal bleeding during the treatment as well as the side effects of mifepristone
* Agreeing to have ultrasound examinations in every follow-up or evaluation visit
* Agreeing in two endometrial biopsies: one before starting treatment and another in the following 10 days after treatment termination

Exclusion Criteria:

* Pregnancy or desire to become pregnant
* Breastfeeding
* Hormonal contraception or any hormonal therapy received in the last three months
* Signs or symptoms of pelvic inflammatory disease
* Adnexal masses
* Abnormal or unexplained vaginal bleeding
* Suspected or diagnosed malignant neoplastic disease
* Signs or symptoms of mental illness
* Adrenal disease
* Sickle cell anemia
* Hepatic disease
* Renal disease
* Coagulopathy
* Any other severe or important disease
* Any contraindication to receiving antiprogestins

Primary outcomes:
measure: Volume of the uterine leiomyomata with 5 versus 10 mg of mifepristone daily after six months of treatment
timeFrame: 6 months
Secondary outcomes:
measure: Prevalence of symptoms after 6 months treatment with 5 or 10 mg of mifepristone.
timeFrame: 6 months
Other outcomes:
Locations:
city: Ciudad Habana
country: Cuba
facility: Hospital Eusebio Hernandez
state: La Habana
Study officials:
affiliation: Mediterranea Medica S. L.
name: Carbonell Josep Ll., MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06274073: Double-dorsal Versus Single-volar Digital Block
Official title: Double-dorsal Versus Single-volar Digital Subcutaneous Anaesthetic Injection for Finger Injuries in the Emergency Department: A Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Laceration of Skin
Anesthesia, Local
Pain
Nerve Block
Keywords: Digital nerve block
Finger lacerations
Single palmar injection
Double dorsal injection
Pain
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2024-02-23
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two parallel groups (two digital block techniques)
Primary purpose: TREATMENT

Brief summary: The aim of this study is to compare the traditional dorsal double injection digital block with the palmar single injection technique in the suturing of acute traumatic hand finger lacerations in terms of injection pain score (NRS), anesthesia onset time, and success of anesthesia.

It is understood that single injection digital block and double injection digital block techniques do not have significant advantages over each other in terms of pain levels and procedure times.

However, the need for rescue anesthesia was evaluated to be lower in the single injection digital block technique. This difference is especially due to measurements in the volar region incisions.

According to the results of this study, we think that choosing the single injection digital block technique for volar region incisions is a more rational approach, especially in terms of the data of the need for rescue anesthesia.

Detailed description: Randomized, parallel controlled, open labeled experimental study

Eligibility criteria: Inclusion Criteria:

* Between 18-65 years of age
* Isolated traumatic acute hand finger lacerations requiring suturing
* Admissions within 6 hours of injury
* Patients who can cooperate with the NRS score
* Patients who gave consent

Exclusion Criteria:

* Vein, nerve and tendon lacerations on the hand that require repair
* Amputation or bone fracture
* Those who have used analgesics in the last 12 hours
* Hemodynamically unstable patients
* Known allergy to prilocaine hydrochloride

Primary outcomes:
measure: Anesthesia pain score
timeFrame: 3rd minute
Secondary outcomes:
measure: Anesthesia onset time
timeFrame: Measurements are provided per 30 seconds (30-60-90-120 seconds and more if necessary)
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara City Hospital Emergency Medicine Department
Study officials:
affiliation: Ankara Yıldırım Beyazıt University Faculty of Medicine
name: Alp Şener, Assoc prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01540773: Single Low-Dose of Supplement Amino Acid
Official title: Growth Hormone 120 Minutes Following a Single Low-dose of Amino Acids in Healthy Subjects.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Growth Hormone
Amino Acid
Keywords: growth hormone
Lead sponsor: Pennington Biomedical Research Center
Sponsor class: OTHER
First posted: 2012-02-29
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of the study is to confirm the results of a prior study that demonstrated pills containing two amino acids which are in foods increased growth hormone and insulin-like growth factor-1.

Detailed description: Oral supplementation with a key combination of derivatives that has been shown to increase human growth hormone in healthy volunteers peaking at 90 minutes and IGF-1 at 8 hours post-administration.

Eligibility criteria: Inclusion Criteria:

* healthy males and healthy females
* Between 18 and 70 years

Exclusion Criteria:

* Pregnant or nursing
* Taking any chronic medication including birth control pills.

Primary outcomes:
measure: Change From Baseline of Growth Hormone
timeFrame: 0-120 minutes, at Baseline and post dose, week 1 and week 3
measure: Area Under the Curve of Growth Hormone Over Baseline
timeFrame: 0-120 minutes, at Baseline and post dose, week 1 and week 3
Secondary outcomes:
measure: Insulin-like Growth Factor 1
timeFrame: 8 hours following administration
Other outcomes:
Locations:
city: Baton Rouge
country: United States
facility: Pennington Biomedical Research Center
state: Louisiana
Study officials:
affiliation: Pennington Biomedical Research Center
name: Frank Greenway, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tam CS, Johnson WD, Rood J, Heaton AL, Greenway FL. Increased Human Growth Hormone After Oral Consumption of an Amino Acid Supplement: Results of a Randomized, Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects. Am J Ther. 2020 Jul/Aug;27(4):e333-e337. doi: 10.1097/MJT.0000000000000893.
Clinical trial NCT06808373: The Effect of Hypnosis on Periodontal Treatment
Official title: The Effect of Hypnosis on Healing in Patients Undergoing Phase I Periodontal Therapy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Peridontal Disease
Dental Anxiety
Keywords: periodontitis, hypnosis, dental anxiety
Lead sponsor: Afyonkarahisar Health Sciences University
Sponsor class: OTHER
First posted: 2025-02-05
Enrollment: 50
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Treatment of periodontal diseases relies on the mechanical removal of microbial dental plaque, calculus, and necrotic cementum from root surfaces in both supra- and subgingival areas to control inflammation in periodontal tissues. As in all dental treatments, dental phobia and dental anxiety are common challenges in initial periodontal therapy. Hypnosis is among the traditional non-pharmacological behavior management techniques used to manage stress and improve pain tolerance. It is known that hypnosis is effective in anxiety control in dentistry. The use of salivary levels of inflammatory mediators released during the disease is a valid method for assessing the progression of periodontal disease and healing after treatment. In this study, the effect of hypnosis on healing in patients undergoing Phase I periodontal therapy will be evaluated by comparing the mean differences in cytokine levels between case and control groups


Eligibility criteria: Inclusion Criteria:

Being between the ages of 20-65 Not having any systemic disease Having chronic periodontal disease Having the ability to understand the study and answer questions

Exclusion Criteria:

Having any systemic disease Being under 20 or over 65 Not having any periodontal disease

Primary outcomes:
measure: measurement of cytokine levels
timeFrame: Pre-treatment (day 0), post-treatment (day 0) and 8 weeks post-treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Afyonkarahisar
country: Turkey
facility: Afyonkarahisar Health Sciences University Faculty of Dentistry
Study officials:
References:
Clinical trial NCT06677073: Effects of FATmax Exercise and HIIT on Fat Loss in Overweight Young Women
Official title: Effects of Maximal Fat Oxidation Exercise and High-intensity Interval Training on Fat Loss in Overweight Young Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Overweight
Keywords: High-intensity interval training
Maximal fat oxidation
Overweight
Fat loss
Female
Lead sponsor: Beijing Sport University
Sponsor class: OTHER
First posted: 2024-11-06
Enrollment: 20
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study investigated the effects of two exercise modalities: high-intensity interval training (HIIT) and maximal fat oxidation (FATmax) exercise on fat loss in overweight young women. Participants were randomly assigned to either the HIIT or FATmax group, underwent an 8-week supervised exercise intervention.

Detailed description: This study aims to compare the effects of HIIT and FATmax exercise on fat loss in overweight young women. Participants were recruited and randomly assigned to either the HIIT group or the FATmax group. The intervention lasted for 8 weeks, during which participants maintained their usual diet. Both body morphology and body composition were assessed before and after the intervention. In order to recommend exercise strategy for overweight young women reduce fat and improve their health.

Eligibility criteria: Inclusion Criteria:

* Female, aged between 18 and 30 years.
* Overweight, BMI greater than 24.0 kg·m-2.
* Participants Lack of exercise habits.
* Participants Without significant fluctuation in weight.

Exclusion Criteria:

* Participants took drugs affecting metabolism and hormones during the experimental period.
* Participants had a history of oral weight loss pills and contraceptive pills.
* Participants had a history of smoking, alcohol consumption, or daily consumption of caffeine-containing beverages.
* Participants had cardiovascular or basal metabolic disorders, such as hypertension, coronary heart disease, or diabetes mellitus.
* Participants had other acute or chronic injuries related to exercise.

Primary outcomes:
measure: Body weight
timeFrame: 8 weeks
measure: Body mass index (BMI)
timeFrame: 8 weeks
measure: Waist circumference
timeFrame: 8 weeks
measure: Hip circumference
timeFrame: 8 weeks
measure: Body fat weight
timeFrame: 8 weeks
measure: Body fat percentage
timeFrame: 8 weeks
measure: Visceral fat area
timeFrame: 8 weeks
Secondary outcomes:
measure: Height
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Beijing
country: China
facility: School of Sports Medicine and Rehabilitation, Beijing Sport University
Study officials:
References:
Clinical trial NCT03885973: Lactobacillus Plantarum IS 10560 Supplementation in Women With Functional Constipation
Official title: Lactobacillus Plantarum IS 10560 Supplementation in Women With Functional Constipation: Molecular Profile of Fecal Microbiome With NGS Method
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Constipation - Functional
Keywords: SCFA
Probiotic
Lactobacillus plantarum
Functional constipation
Lead sponsor: Fakultas Kedokteran Universitas Indonesia
Sponsor class: OTHER
Collaborators: name: United States Agency for International Development (USAID)
First posted: 2019-03-22
Enrollment: 76
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study, the investigators measured the SCFA (Butyrate, Acetate and Propionate) as a Biomarker improvement symptom and quality of life women with functional constipation after supplementation of commensal bacterial fermented milk Lactobacillus plantarum (isolated from indigenous probiotics from Dadih, West Sumatra) for 21 days


Eligibility criteria: Inclusion Criteria:

* Being declared healthy based on initial examination and the Structured Interview Questionnaire (SIQ)
* Having the symptoms and signs of functional constipation refer to ROME IV
* Able to communicate well
* Able to consume 1 bottle of fermented milk each day for three weeks
* Not using antibiotic no later than one week before supplementation

Exclusion Criteria:

* Diagnosed with functional bowel disorder
* Using anesthesia at least 4 weeks before treatment
* Having a serious pathological disorder (carcinoma)
* During healing phase of acute gastrointestinal disorders at least 4 weeks before treatment
* Having severe heart disease
* Taking chronic medications such as antidepressants or analgesics

Primary outcomes:
measure: Short Chain Fatty Acid (SCFA) titer
timeFrame: Three weeks after intervention
measure: Functional constipation symptom improvement (1)
timeFrame: Three weeks after intervention
measure: Functional constipation symptom improvement (2)
timeFrame: Three weeks after intervention
measure: Molecular Profile of Fecal Microbiome
timeFrame: Three weeks after intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Jakarta
country: Indonesia
facility: Puskesmas Petamburan
state: DKI Jakarta
Study officials:
affiliation: Fakultas Kedokteran Universitas Indonesia
name: Pratiwi D Kusumo
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01244373: A Prospective Observational Case Series of a Four-ring-haptic Acrylic One-piece IOL
Official title: Observational Case Series of the Implantation of Intraocular Lens "QUATRIX® Aspheric Evolutive Pre-loaded".
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cataract
Keywords: Best-corrected visual acuity
posterior capsule opacification
QUATRIX® Aspheric Evolutive pre-loaded
Lead sponsor: General Hospital Linz
Sponsor class: OTHER
Collaborators: name: Department of ophthalmology, General Hospital Linz
First posted: 2010-11-19
Enrollment: 9
Sex: ALL
Minimum age (years): 50
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with advanced age-related cataract and indication for phacoemuslification of the lens with following implantation of an intraocular lens (posterior chamber)

Brief summary: To describe biocompatibility, postoperative results and complications after implantation of the Corneal Quatrix Evolutive (Corneal, Croma, Austria) intraocular lens, a hydrophilic acrylic intraocular lens (IOL) with 4-haptic design and 360° sharp optic edge.

Detailed description: In this prospective case series the Corneal Quatrix Evolutive IOL was implanted in 14 eyes of nine patients with senile cortico-nuclear cataract. A standardized surgical technique and post-operative regimen were applied. Six months postoperatively best corrected visual acuity (BCVA), refraction and complications (especially) posterior capsule opacification (PCO) were analysed.

Eligibility criteria: Inclusion Criteria:

Patients with senile cortico-nuclear cataracts without previous intraocular surgery

Exclusion Criteria:

* Dilated pupil size of \< 6 mm
* long-term anti-inflammatory treatment
* previous history of intraocular surgery
* previous history of corneal endothelial damage
* previous history of ocular trauma
* traumatic cataract
* history of uveitis
* diabetic retinopathy
* advanced macular degeneration

Primary outcomes:
measure: Best-corrected visual acuity (BCVA)
timeFrame: Six months
Secondary outcomes:
measure: Posterior capsule opacification
timeFrame: Six months
Other outcomes:
Locations:
city: Linz
country: Austria
facility: Department of ophthalmology, General Hospital Linz
state: Upper Austria
Study officials:
References:
citation: Kramer S, Schroder AC, Bruckner K, Jonescu-Cuypers C, Seitz B. [Subluxation of hydrophilic acrylate intraocular lenses due to massive capsular fibrosis]. Ophthalmologe. 2010 May;107(5):460-4. doi: 10.1007/s00347-009-2025-y. German.
citation: Michael K, O'Colmain U, Vallance JH, Cormack TG. Capsule contraction syndrome with haptic deformation and flexion. J Cataract Refract Surg. 2010 Apr;36(4):686-9. doi: 10.1016/j.jcrs.2009.09.042.
Clinical trial NCT04933773: SpO2 Measurement Depending on Different Pulse Oximeter Averaging Time Settings
Official title: SpO2 Measurement Depending on Different Pulse Oximeter Averaging Time Settings
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Movement Artifacts During SpO2 Measurements
Reduced Perfusion During SpO2 Measurements
Keywords: pulse oximetry
SpO2
averaging time
motion artifacts
Lead sponsor: Czech Technical University in Prague
Sponsor class: OTHER
First posted: 2021-06-22
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: All participants go through all study arms, in random order. Two pulse oximeters with different averaging time settings are active simultaneously during measurement on each participant and the measured signal is compared.
Primary purpose: OTHER

Brief summary: The aim of this study is to characterize the noise in the SpO2 signal depending on different pulse oximeter averaging time settings.

Detailed description: Noise in the SpO2 signal is most often caused by artifacts, such as movement artifacts, reduced perfusion, additional light and others. These artifacts can be partially removed from the SpO2 signal by different pulse oximeter settings, specifically the sensitivity mode and averaging time. It is known that when a longer averaging time is set, the measured signal contains fewer artifacts, on the other hand there is an increased risk of missing short desaturation. The aim of this work is to characterize the noise in the SpO2 signal depending on the set averaging time of the pulse oximeter based on experimental data from healthy volunteers.

Eligibility criteria: Inclusion Criteria:

* healthy volunteers from the Czech Technical University

Exclusion Criteria:

* pregnancy
* severe cardiovascular conditions
* injury to the upper limbs or hands that could affect the peripheral perfusion
* diabetes
* hypotension or hypertension

Primary outcomes:
measure: SpO2 readings with different averaging times
timeFrame: 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Kladno
country: Czechia
facility: Faculty of Biomedical Engineering, Czech Technical University in Prague
Study officials:
affiliation: Czech Technical University in Prague
name: Veronika Rafl Huttova
role: PRINCIPAL_INVESTIGATOR
References: