Clinical trial NCT05340010: Administration of Human Chorionic Gonadotrophin Before Secretory Transformation of Frozen-thawed Embryo Transfer Cycles
Official title: Administration of Human Chorionic Gonadotrophin Before Secretory Transformation of Frozen-thawed Embryo Transfer Cycles
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: hCG
FET
Frozen-thawed Embryo Transfe
Human Chorionic Gonadotrophin
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2022-04-21
Enrollment: 180
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 38
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Successful embryo implantation is complicated process that requires synchrony between good-quality embryos and receptive endometrium. Human chorionic gonadotropin (hCG), is one of the initial embryonic signals and the major embryoendometrial relationship regulator. This study will be conducted to to investigate the role of parenteral hCG used for the transfer of cryopreserved- thawed embryos with HRT cycles in the outcome of artificially prepared frozen embryo transfer (FET) cycles.


Eligibility criteria: Inclusion Criteria:

* Patient age ≤ 38 years.
* Normal 3D transvaginal ultrasound.
* At least two good quality embryos cryopreserved by vitrification.
* No GnRH agonists administration before FET cycle.

Exclusion Criteria

* Endometriosis.
* Uterine anomalies.
* Evidence of hydrosalpinx by hystrosalpingography or ultrasound.
* Evidence of immune disease, hematological or hormonal disorder.

Primary outcomes:
measure: Live birth delivery rate (LBR)
timeFrame: 7 months
Secondary outcomes:
measure: Clinical pregnancy rate
timeFrame: 2 weeks after positive pregnancy test
measure: Implantation rate
timeFrame: 2 weeks after positive pregnancy test
measure: Miscarriage rate
timeFrame: 20 weeks gestational age
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Alexandria university
Study officials:
References:
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