Clinical trial NCT04174495: Bone Fragility Evaluation in Obese Patients
Official title: Bone Fragility Evaluation by Dual X-Ray Absorptiometry (DXA) and CT-scan (vertebral Fracture and Scanographic Bone Attenuation Coefficient of the First Lumbar Vertebra SBAC-L1) in Obese Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Bariatric Surgery Candidate
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
Collaborators: name: Centre Hospitalier de Toul Saint Charles
First posted: 2019-11-22
Enrollment: 1500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: obese patients followed before a bariatric surgery, at Nancy university hospital who performed a CT-scan and DXA, usually performed before surgery, with a delay which did not exceed 1 year before the 2 exams

Brief summary: This research will study the bone fragility in obese patients, on DXA and CT-scan, in a transversal study. The investigators want also to study the specific risk factors of bone fragility in these obese patients (relationship between body composition on whole body on DXA, fat mass and its location, lean mass, weight loss after surgery and SBAC-L1), to improve the bone screening.


Eligibility criteria: Inclusion Criteria:

* patients followed at Nancy university hospital for a bariatric surgery
* CT-scan and DXA performed before surgery, with maximum 1 year before the 2 exams

Exclusion Criteria:

* \< 18 years
* Protected adults

Primary outcomes:
measure: scanographic bone attenuation coefficient of the first lumbar vertebra SBAC-L1
timeFrame: November 2019-September 2020
Secondary outcomes:
measure: Vertebral fracture
timeFrame: November 2019-September 2020
measure: DXA: T-score
timeFrame: November 2019-September 2020
measure: DXA: Bone mineral density BMD (spine, hip , femoral neck, wrist)
timeFrame: November 2019-September 2020
measure: DXA: lean and fat mass
timeFrame: November 2019-September 2020
Other outcomes:
Locations:
city: Vandœuvre-lès-Nancy
country: France
facility: Nancy university hosiptal
Study officials:
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