Clinical trial NCT03700827: Effects of Aerobic and Resistance Training on Abdominal Fat Loss
Official title: Effects of Aerobic and Resistance Training on Abdominal Fat Loss
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Obesity, Abdominal
Keywords: Abdominal Fat
Visceral Adipose Tissue
Subcutaneous Adipose Tissue
Exercise
Intervention
Lead sponsor: Southern Illinois University Edwardsville
Sponsor class: OTHER
Collaborators: name: Washington University School of Medicine
First posted: 2018-10-09
Enrollment: 18
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Study the effects of different exercise modes on total and regional adiposity variation in subcutaneous and visceral adipose tissue (VAT and SAT). The investigators hypothesize that total abdominal will improve for all the exercise groups compared to the control group. When comparing intervention groups: 1) no differences on the degree of improvement in total abdominal fat depots (VAT and SAT) 2) different degree of change when comparing specific sections at VAT and SAT are expected.


Eligibility criteria: Inclusion Criteria:

* 30 - 39.9 kg/m2 BMI
* White/Caucasian
* Female
* Sedentary

Exclusion Criteria:

* Known cardiovascular, pulmonary, metabolic disease
* Pregnant females
* Any excluded criteria with MRI scans (i.e. certain metal implants, recent tattoos)
* Diabetic
* Hypertension
* Cigarette smoking
* MRI related contraindications (metal, no removable devices, etc.)

Primary outcomes:
measure: Changes in Visceral Abdominal Tissue (VAT)
timeFrame: 2 assessment periods: at baseline and week 4
Secondary outcomes:
measure: Changes in Subcutaneous Abdominal Tissue (SAT)
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in Muscular Strength
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in Cardiorespiratory Function
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in fat mass (kg)
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in relative body fat (%BF)
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in relative lean body mass (kg)
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in Lipid profile (TG, Total Cholesterol, HDL2 HDL3, LDL)
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in concentration of Troponin
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in concentration of Fibrinogen
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in concentration of C-reactive protein (CRP)
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in concentration of IL-6
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in concentration of IL-10
timeFrame: 2 assessment periods: at baseline and week 4
measure: Changes in concentration of TNF-alpha
timeFrame: 2 assessment periods: at baseline and week 4
Other outcomes:
Locations:
city: Edwardsville
country: United States
facility: Southern Illinois University of Edwardsville
state: Illinois
Study officials:
affiliation: Southern Illinois University of Edwardsville
name: Maria Fernandez del Valle, PhD
role: PRINCIPAL_INVESTIGATOR
References: