louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05962723: Pancreatic Cyst Fluid Glucose: New Armamentarium in the Diagnosis of Mucinous Pancreatic Cystic Lesion
Official title: Pancreatic Cyst Fluid Glucose: New Armamentarium in the Diagnosis of Mucinous Pancreatic Cystic Lesion
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Pancreatic Cyst Fluid
Lead sponsor: Asian Institute of Gastroenterology, India
Sponsor class: OTHER
First posted: 2023-07-27
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants with pancreatic cyst of size \>2 cm, seen on radiological image, having no contraindication for endoscopic ultrasound and has not suffered from pancreatitis within last 3 months) coming to OPD/admitted in ward in AIG Hospital , Hyderabad satisfying inclusion and exclusion criteria after informed consent, will be included.

Brief summary: All participants undergoing radiological imaging and found to have pancreatic cyst of size \> 2cm will be subjected to EUS (Endoscopic ultrasound) examination and cystic fluid will be aspirated for analysis, including cystic fluid Glucose, CEA, amylase. Morey's biopsy will be done in the cases feasible for biopsy. The sensitivity and specificity of cystic fluid glucose level will be analysed taking CEA (carcinoembryonic antigen) level with EUS findings, amylase level as gold standard for diagnosis, in cases with no surgical management.

Detailed description: Pancreatic cystic lesion prevalence noted to be increased dramatically in last few decades. Earlier record showed the prevalence rate of 2.4-2.6% with magnetic resonance imaging (MRI), though sometimes reaching 13.5%.Recent study showed prevalence of pancreatic cysts to be 49%. Most of the pancreatic cyst are benign and require conservative management and regular evaluation only. Malignant cystic lesion on the other hand require immediate attention and surgical excision in most of cases. Thus, diagnosis of pre-malignant \& malignant pancreatic cyst are essential, to predict the prognosis and decide further management.

Most widely accepted biochemical test for preoperative differentiation of mucinous from benign pancreatic cysts is cystic fluid carcinoembryonic antigen (CEA). CEA with cutoff value of 192 ng/ml has sensitivity, specifivcity and accuracy of 75%, 84% \& 79% respectively. This is expensive and requires a longer duration for obtaining the results. Few recent studies proposed the role of cystic fluid glucose level in the diagnosis of malignant cyst.

Eligibility criteria: Inclusion Criteria:

* Patients (between 18 to 60 years of age)
* Pancreatic cyst of size \>2 cm noted on radiological imaging

Exclusion Criteria:

* Patient's age \<16yrs or \>80 yrs.
* Prior history of pancreatitis (within 3 months)
* Pregnant female
* Unfit for endoscopic ultrasound
* Not wiling for consent

Primary outcomes:
measure: sensitivity, specificity and accuracy
timeFrame: One Year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05020223: Comparison of Sucess of Pulpotomy, Direct Pulp Capping and Indirect Pulp Capping Modalities Using MTA in Primary Teeth
Official title: Comparison of Sucess of Pulpotomy, Direct Pulp Capping and Indirect Pulp Capping Modalities Using MTA in Primary Teeth (2 Years Follow up)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Deep Caries
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2021-08-25
Enrollment: 450
Sex: ALL
Minimum age (years): 3
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: 450 healthy children with primary teeth of deep carious lesions without signs or symptomes of irreverisible pulp damage was selected randompy divoded into 3 groups each of 150 children that inder go vital pulp therapy through pulpotomy,direct pulp capping or indirect pulp capping using MTA as capping material for each modality then followed up for 2 years or more


Eligibility criteria: Inclusion Criteria:

* Healthy children
* Aged from 3 to 10 years old
* Deep cariuos primary tooth

Exclusion Criteria:

* Primary teeth with any signs or syptoms of irreversible pulpitis
* Primary teeth of any signs or symptomes of vitality loss
* Primary teeth near to exfoliation

Primary outcomes:
measure: Tenderness
timeFrame: 2 years
measure: Abcess
timeFrame: 2 years
measure: Fistula
timeFrame: 2 years
measure: lamina dura
timeFrame: 2 years
measure: Periapical radiographic radiolucency
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Minya
country: Egypt
facility: Minia University
Study officials:
References:
Clinical trial NCT02313623: MR-US Image Fusion Targeted Biopsy for Single-cell Prostate Cancer Research
Official title: MR-US Image Fusion Targeted Biopsy for Single-cell Prostate Cancer Research
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Prostate Cancer
Lead sponsor: Yale University
Sponsor class: OTHER
First posted: 2014-12-10
Enrollment: 600
Sex: MALE
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with scheduled Artemis fusion biopsy will be recruited into this study.

Brief summary: The investigators hypothesize that this single-cell analysis can be used to evaluate prostate needle-core biopsies prospectively even in non-homogenous samples by providing profiles of proteomic and phenotypic signatures. These profiles will in turn enable better predictions of the malignant progression of prostate cancers in the settings of current clinical practice.

Detailed description: Current approaches for early detection and diagnosis include prostate-specific antigen (PSA) which is a useful, though not specific, biomarker for detecting prostate cancer. The suspected patients will be further sent for digital rectal examination(DRE), in which a doctor inserts a lubricated, gloved finger into the patient's rectum to feel for lumps, enlargements, or areas of hardness that might indicate prostate cancer. However, the only test that can fully confirm the diagnosis of prostate cancer is a biopsy - the removal of small pieces of the prostate for microscopic examination. If cancer is suspected using PSA test and DRE, more than 90% suspected patients choose undergo prostate biopsy. Prostate needle biopsies are routinely done on an outpatient basis and rarely require hospitalization. Markedly, the fine needle biopsy is minimally invasive and has currently been suggested for longitudinal monitoring of highly suspected patients or follow-up therapeutic responses. The large availability of biopsy samples for prostate cancer provides a cornerstone for the proposed patient specimen-based research. The investigators anticipate that comprehensive analysis rather than simple pathological examination of these samples will generate new insights to prostate tumor progression in human.

Eligibility criteria: Inclusion Criteria:

* Only subjects that have scheduled Artemis prostate biopsy with defined regions of interest will be included in this study

Exclusion Criteria:

* Any subjects that are unable to provide informed consent will be excluded

Primary outcomes:
measure: Success Rate of Primary Prostate Cell Culture
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Yale University
state: Connecticut
Study officials:
affiliation: Yale University
name: Preston C Sprenkle, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00544323: Alveolar Bone Loss Around 3 Different Designs of Dental Implant: Prospective Comparative Clinical Trail
Official title: Alveolar Bone Loss Around 3 Different Designs of Dental Implant: Prospective Comparative Clinical Trail
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Alveolar Bone Loss
Keywords: alveolar bone
radiographic alveolar bone changes around oral implants of various designs 12 m post loading
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2007-10-16
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: comparison of alveolar bone resorbtion/ changes for a period of 12 month post loading of different designs and brands of oral implants. in this study, a comparison between straumann SLA-active implants to MIS Mistral and Mistral -X implants.


Eligibility criteria: Inclusion Criteria:

* healthy
* \>18Y
* consent
* posterior mandibular missing teeth

Exclusion Criteria:

* chronic illness: diabetes, artheritis
* women: pregnancy, lactation
* non consent
* alcohol consumption
* smoking \>10 p day

Primary outcomes:
measure: radiographic changes in the alveolar bone height around the oral implant till 12 m post loading
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah medical center, school of dentistry
Study officials:
affiliation: Hadassah Medical Organization
name: Lior Shapira Prof
role: STUDY_CHAIR
References:
Clinical trial NCT06734923: Media and Social Networks Consultation and Associated Factors Among Orthodontic Patients
Official title: Survey on Media and Social Networks Consultation Among Patients Taken Care in the Orthodontics Unit At the Nice University Hospital: a Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dental Care
Using Social Media and Networks to Find Out About Orthodontic Treatment
Lead sponsor: Centre Hospitalier Universitaire de Nice
Sponsor class: OTHER
First posted: 2024-12-16
Enrollment: 65
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients present in the waiting room during the period of questionnaire distribution at the Orthodontic Unit of the Nice University Hospital

Brief summary: "Context : An increasing number of patients are using the internet and social media to obtain information about oral health, including the field of orthodontics.

Aim : This study aimed to analyze the behavior and habits of patients regarding the use of social media to obtain information about orthodontics, as well as the factors associated with this usage.

Materials and methods : The study was designed as a single-center, cross-sectional, descriptive study. Orthodontic patients filled out a 28-question questionnaire that gathered demographic data, information-seeking behavior, platform use and online consultation habits, trust and impact, and interest in additional resources. A univariate and multivariate logistic regression models/analysis were conducted using Excel and IBM SPSS Statistics Version 29.0.1.0, (employing Chi2, Fisher's exact tests, univariate and multivariate models)."


Eligibility criteria: Inclusion Criteria:

- All patients, whether adults or minors accompanied by their legal representative, who consulted in the orthodontics unit, and had access to the internet.

Exclusion Criteria:

- All patients who declined to participate.

Primary outcomes:
measure: online research of orthodontic information
timeFrame: At the inclusion
Secondary outcomes:
measure: trust in the information gathered
timeFrame: At the inclusion
measure: The impact of online and social media information on orthodontic patients' decision-making
timeFrame: At the inclusion
Other outcomes:
Locations:
city: Nice
country: France
facility: CHU NICE
state: Alpes-Maritimes
Study officials:
References:
Clinical trial NCT02064023: Comparison of Insulin Pump and MDI for Pregestational Diabetes During Pregnancy
Official title: Comparison of Continuous Subcutaneous Insulin Infusion (CSII) With Multiple Daily Injections (MDI) for the Treatment of Pregestational Diabetes During Pregnancy
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Type 1 Diabetes
Type 2 Diabetes
Pregnancy
Keywords: insulin pump
CSII
multiple daily injections
MDI
type 1 diabetes
type 2 diabetes
pregnancy
Lead sponsor: University of British Columbia
Sponsor class: OTHER
First posted: 2014-02-17
Enrollment: 2
Sex: FEMALE
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is investigating whether insulin treatment with the insulin pump or with multiple daily injections (MDI) gives better outcomes for mother and baby in pregnant women with pregestational diabetes. Participants will be randomized to use either the insulin pump or MDI.

Detailed description: Primary outcome is a composite of Cesarian section, instrumental delivery, maternal hypertension, LGA infant, neonatal hypoglycemia or SCN admission.

Eligibility criteria: Inclusion Criteria:

* subjects are attending the Diabetes Pregnancy Clinic at participating hospitals
* have had type 1 or type 2 diabetes for at least one year
* are in the first trimester or are actively attempting pregnancy
* have a singleton pregnancy
* are receiving intensive insulin therapy
* are judged by clinic staff to be capable of using an insulin pump
* are age 19 or older
* are willing to adhere to the study protocol including monitoring blood glucose levels
* are willing to take folic acid before pregnancy and during the first trimester
* are willing to discontinue any medication contraindicated in pregnancy prior to conception
* weigh less than 100 kg (220 lb) prior to becoming pregnant
* use less than 100 units of insulin per day

Exclusion Criteria:

* current or previous use of an insulin pump
* use of fertility treatments
* have a multiple pregnancy
* have had children born with major birth defects
* have experienced stillbirth or multiple early pregnancy losses
* have significant diabetes complications or a serious medical issue

Primary outcomes:
measure: Composite obstetrical/perinatal endpoint consisting of specific elements (see description)
timeFrame: Up to 42 weeks
Secondary outcomes:
measure: Mean maternal HbA1c during pregnancy
timeFrame: up to 42 weeks
Other outcomes:
measure: Number of episodes of severe hypoglycemia
timeFrame: up to 42 weeks
Locations:
city: Surrey
country: Canada
facility: Jim Pattison Outpatient Care and Surgery Centre
state: British Columbia
city: Vancouver
country: Canada
facility: B.C. Women's Hospital
state: British Columbia
Study officials:
affiliation: University of British Columbia
name: David M Thompson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05642923: Post-COVID-19 Chronic Fatigue Syndrome
Official title: Post-COVID-19 Chronic Fatigue Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Post-COVID-19 Syndrome
Post-COVID Syndrome
Lead sponsor: ClinAmygate
Sponsor class: OTHER
Collaborators: name: As-Salam Center, Maadi, Cairo, Egypt
First posted: 2022-12-08
Enrollment: 528
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Fatigue is recognized as one of the most commonly presented long-term complaints in individuals previously infected with SARS-CoV-2.

Detailed description: It has become increasingly clear that infected patients have symptoms not only in the acute phase, but also after recovery from the initial infection.

A recent meta-analysis including 4828 patients with post-COVID-19 showed that symptoms and post-acute sequelae of SARS-CoV-2 can persist weeks to months after the infection.

These patients who reported persistent symptoms have been termed "long haulers" or described as having long COVID, post-acute COVID-19, persistent COVID-19 symptoms, post COVID-19 manifestations, long-term COVID-19 effects, post-acute sequelae of COVID-19 (PASC), or post-COVID-19 syndrome.

Eligibility criteria: Inclusion Criteria:

* Age . 18
* Male or female
* Post-Covid-19 Fatigue

Exclusion Criteria:

* refusal

Primary outcomes:
measure: Fatigue scale
timeFrame: one month
measure: Fatigue scale
timeFrame: two month
measure: Fatigue scale
timeFrame: three month
Secondary outcomes:
measure: Incidence of adverse events
timeFrame: 6 months
Other outcomes:
Locations:
city: Maadi
country: Egypt
facility: Asalam
state: Cairo
Study officials:
References:
citation: Jackson C. The Chalder Fatigue Scale (CFQ 11). Occup Med (Lond). 2015 Jan;65(1):86. doi: 10.1093/occmed/kqu168. No abstract available.
citation: Kedor C, Freitag H, Meyer-Arndt L, Wittke K, Hanitsch LG, Zoller T, Steinbeis F, Haffke M, Rudolf G, Heidecker B, Bobbert T, Spranger J, Volk HD, Skurk C, Konietschke F, Paul F, Behrends U, Bellmann-Strobl J, Scheibenbogen C. A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity. Nat Commun. 2022 Aug 30;13(1):5104. doi: 10.1038/s41467-022-32507-6.
Clinical trial NCT04015323: The Efficacy of Interferential Current Treatment on Knee Osteoarthritis
Official title: The Efficacy of Interferential Current Treatment on Knee Osteoarthritis: A Randomized Double Blind Study That Compares the Effects of Different Carrier Frequencies
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Osteoarthritis
Keywords: interferential current
knee osteoarthritis
pain
Lead sponsor: Ege University
Sponsor class: OTHER
First posted: 2019-07-10
Enrollment: 61
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The effects of different carrier frequencies of interferential current on pain and function in patients with knee arthrosis will be compared

Detailed description: 60 patients with knee osteoarhthritis will be enrolled in the study. Subjects will be randomized to 3 groups. All patients will receive interferential currents to both their knees, with different carrier frequencies (2, 4 and 8 kilohertz (kHz) respectively). The effect of different types of carrier frequencies on pain, 10 meter walk test will be analysed.

Eligibility criteria: Inclusion Criteria:

* Age between 50-80 years
* Knee VAS pain scores ≥ 4
* Kellgren-Lawrence radiologic scores 2 and 3

Exclusion Criteria:

* History of knee surgery
* Inflammatory arthritis
* Paralysis of lower extremities
* Serious cardiovascular disease /presence of cardiac pacemaker
* Severe osteoarhthritis of lower extremity joints other than the knees
* History of newly diagnosed cancer (ın the last 6 months)
* Cognitive impairment

Primary outcomes:
measure: Change in pain scores according to visual analog scale (VAS)
timeFrame: At baseline, on the 3rd week visit (last day of interference therapy) and on the 7th week visit
Secondary outcomes:
measure: Change in functional status levels according to Western Ontario and McMaster Universities Arhtiritis Incex (WOMAC) scale
timeFrame: At baseline, on the 3rd week visit (last day of interference therapy) and on the 7th week visit
measure: Change in pain status levels according to Western Ontario and McMaster Universities Arhtiritis Incex (WOMAC) scale
timeFrame: At baseline, on the 3rd week visit (last day of interference therapy) and on the 7th week visit
measure: Change in 10 meter walking test score
timeFrame: At baseline, on the 3rd week visit (last day of interference therapy) and on the 7th week visit
measure: Change in the number of paracetamol tablets taken in a week
timeFrame: At baseline, on the 3rd week visit (last day of interference therapy) and on the 7th week visit
Other outcomes:
Locations:
city: Izmir
country: Turkey
facility: Ege University School of Medicine
Study officials:
affiliation: Ege University
name: Benil N Ata, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02000323: Early Enteral Nutrition in Severe Acute Pancreatitis
Official title: Early Enteral Nutrition in Severe Acute Pancreatitis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pancreatitis
Keywords: pancreatitis
enteral nutrition
Lead sponsor: Ruijin Hospital
Sponsor class: OTHER
Collaborators: name: RenJi Hospital
First posted: 2013-12-04
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: to compare different time points for enteral nutrition in SAP patients

Detailed description: There is increasing evidence that indicates Early Enteral Nutrition（EEN） may be associated with improved outcome in acute pancreatitis patients. However, some SAP patients failed to EEN. The researchers of this study aim to investigate the opportunity of EEN on the clinical outcomes of SAP patients.

Eligibility criteria: Inclusion Criteria:

1. Diagnosis of pancreatitis: Typical pain increase in serum lipase or amylase
2. Onset of abdominal pain within \<=72h before admission
3. moderate severe or severe Acute Pancreatitis according to Atlanta criteria revisited in 2012 ffff

   Exclusion Criteria:
   * 1. Pregnancy 2.tumor 3. acute onset of chronic pancreatitis
4. chronic disease of any organ （heart lung gastrointestinal renal etc.） 5. Pre-existing disease with life expectancy \< 3 months 7.receive parenteral nutrition or enteral nutrition before admitting

Primary outcomes:
measure: mortality
timeFrame: 28days
Secondary outcomes:
measure: operation rate
timeFrame: 2 months
measure: fulfilling enteral nutrition target（≥25Kcal/kg/day）
timeFrame: 7 days
Other outcomes:
measure: inta-abdominal infection
timeFrame: 2 months
Locations:
city: Shanghai
country: China
facility: Ruijin
state: Shanghai
Study officials:
affiliation: Emergency intensive care unit of Ruijin Hospital
name: Qiang en Mao, phd
role: STUDY_DIRECTOR
affiliation: doctor
name: Wen xu, Master
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ong JP, Fock KM. Nutritional support in acute pancreatitis. J Dig Dis. 2012 Sep;13(9):445-52. doi: 10.1111/j.1751-2980.2012.00611.x.