louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00551408: Endothelial Progenitor Cells and Pulmonary Idiopathic Arterial Hypertension
Official title: The Determination of Endothelial Progenitor Cells in Pulmonary Idiopathic Arterial Hypertension.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pulmonary Idiopathic Arterial Hypertension
Lead sponsor: Unidad de Investigacion Clinica en Medicina S.C.
Sponsor class: NETWORK
First posted: 2007-10-31
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with IPAH between 18 and 70 years of age of either gender were invited to participate in the study

Brief summary: Endothelial dysfunction ultimately represents an imbalance between the magnitude of injury and the capacity for repair.

Current evidence established that endothelial progenitor cells (EPC) participate in several models of vascular disease as acute coronary syndromes, stroke, diabetes, peripheral artery disease, etc. However EPC in the setting of PAH is less well established. The target of this study is to demonstrate if the number of EPC is increased in a mexican population of patients with PAH.


Eligibility criteria: Inclusion Criteria:

* Patients were included in the study if they were in The WHO functional class II to III, and had a mean pulmonary artery pressure \>30 mm Hg on right heart catheterization. The ability to walk \>50 m during a standardized 6-min walk test.

Exclusion Criteria:

* Pulmonary hypertension as a result of heart disease, pulmonary disease, sleep-associated disorders, chronic thromboembolic disease, autoimmune or collagen vascular disease, HIV infection, liver disease, major bleeding requiring blood transfusion,renal dysfunction, and evidence for malignant diseases were excluded.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Monterrey
country: Mexico
facility: Unidad de Investigacion Clinica en Medicina SC.
state: Nuevo Leon
Study officials:
affiliation: Unidad de Investigacion Clinica en Medicina SC.
name: Carlos J Sanchez Diaz, MD.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02695108: Scapular Stabilization Exercise on Neck Pain
Official title: Scapular Stabilization Exercise on Mechanical Neck Pain: A Randomized Control
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neck Pain
Keywords: Scapula
Neck
Pain
Therapy
Kinematic
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2016-03-01
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Neck pain is a very common problem in the population. Most of the patients suffer from neck pain for long time and the problem becomes chronic. The investigators studied the effects of scapular stabilization exercise on mechanical neck pain.

Detailed description: Neck is one of the most common musculoskeletal problem in the world. Yet the problem still haven't been understood and solved completely. Its incidence is also becoming higher and most people who have neck pain suffer from it for long time. Several problems have been related to neck pain. Hence, the investigators designed a study to see the effects of scapular stabilization exercise on neck pain.

Eligibility criteria: Inclusion Criteria:

* having neck pain at least 6 months
* having score of at least 10 points from Neck Disability Index
* having type-1, type-2 or type-3 scapula from Kibler's four types rating system
* no previous shoulder or neck surgery
* no accompanying shoulder problem

Exclusion Criteria:

* no complying to the rehabilitation
* if patient wants to finished and don't want to complete study, they were excluded

Primary outcomes:
measure: Neck pain measured with Visual Analog Scale
timeFrame: 6 weeks
Secondary outcomes:
measure: Quality of Life measured with Neck Disability Index
timeFrame: 6 weeks
measure: Scapular Kinematics measured with 3-D motion monitor device
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University
Study officials:
affiliation: supervisor of the study
name: İrem Düzgün
role: STUDY_DIRECTOR
References:
citation: Helgadottir H, Kristjansson E, Mottram S, Karduna AR, Jonsson H Jr. Altered scapular orientation during arm elevation in patients with insidious onset neck pain and whiplash-associated disorder. J Orthop Sports Phys Ther. 2010 Dec;40(12):784-91. doi: 10.2519/jospt.2010.3405. Epub 2010 Oct 22.
citation: Helgadottir H, Kristjansson E, Einarsson E, Karduna A, Jonsson H Jr. Altered activity of the serratus anterior during unilateral arm elevation in patients with cervical disorders. J Electromyogr Kinesiol. 2011 Dec;21(6):947-53. doi: 10.1016/j.jelekin.2011.07.007. Epub 2011 Sep 1.
citation: Cagnie B, Struyf F, Cools A, Castelein B, Danneels L, O'leary S. The relevance of scapular dysfunction in neck pain: a brief commentary. J Orthop Sports Phys Ther. 2014 Jun;44(6):435-9. doi: 10.2519/jospt.2014.5038. Epub 2014 May 10.
Clinical trial NCT05426408: Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3
Official title: Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3 - Pilot Study of Prevalence of Coronary Microvascular Dysfunction in Myocardial Infarction with Nonobstructive Coronary Arteries
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Myocardial Infarction with Nonobstructive Coronary Arteries
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
Collaborators: name: Region Stockholm
First posted: 2022-06-22
Enrollment: 85
Sex: ALL
Minimum age (years): 35
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Patients will be their own controls
Primary purpose: DIAGNOSTIC

Brief summary: The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.


Eligibility criteria: Inclusion Criteria:

* a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis ≥50%
* age 35-80 years
* reading and writing proficiency in Swedish

Exclusion Criteria:

* Claustrofobia
* Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III)
* Asthma or severe chronic obstructive lung disease
* eGFR \< 30 ml/min
* spontaneous coronary artery dissection
* acute pulmonary embolism
* acute myocardial infarction type 2
* cardiomyopathy other than takotsubo syndrome
* a previous myocardial infarction due to CAD

Primary outcomes:
measure: Diagnostic yield
timeFrame: Through investigation completion, usually 2 hours
Secondary outcomes:
measure: Prevalence of CMD in MINOCA
timeFrame: Through investigation completion, usually 2 hours
measure: Prevalence of CMD in different final MINOCA diagnoses
timeFrame: Through investigation completion, usually 2 hours
measure: Angina pectoris
timeFrame: 3 Months
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Per Tornvall
Study officials:
affiliation: Karolinska Instítutet
name: Per Tornvall, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00000208: Methadone/Buprenorphine Cross-Over Study - 4
Official title: Methadone/Buprenorphine Cross-Over Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Opioid-Related Disorders
Lead sponsor: National Institute on Drug Abuse (NIDA)
Sponsor class: NIH
First posted: 1999-09-21
Enrollment: 0
Sex: ALL
Minimum age (years): 21
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to explore ways to cross patients over from methadone to buprenorphine.


Eligibility criteria: Inclusion Criteria:

M/F ages 21-50. Opiate dependence according to DSM-IV critera. Self-reported use within the last 30 days. Agreeable to conditions of study and signed informed consent.

Exclusion Criteria:

Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative-hynotics. Acute hepatitis. Other medical conditions that deem participation to be unsafe.

Primary outcomes:
measure: Drug use
measure: Withdrawal symptoms
measure: Opiate craving
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Friends Research Institute
state: California
Study officials:
affiliation: Friends Research Institute, Inc.
name: Walter Ling, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00517608: Monopolar Scissors vs Bipolar Vessel Sealer vs Ultrasonic Shears: A Prospective Randomized Study in Laparoscopic Colorectal Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colorectal Disease
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2007-08-17
Sex: ALL
Minimum age (years): 18
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Monopolar electro surgery scissors (MES), electro thermal bipolar vessel sealer (BVS) and ultrasonically coagulating shears (UCS) are all applied in laparoscopic colorectal surgery. We aimed to compare the different devices with regard to dissection time, blood loss, technical aspects and costs.

* Trial with surgical intervention


Eligibility criteria: Inclusion criteria: All patients undergoing laparoscopic left-sided colorectal resection.

Exclusion criteria: \< 18 years no informed consent restricted communication abilities (language, mental illness)

Primary outcomes:
measure: Dissection time
Secondary outcomes:
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: University Hospital of Zurich
Study officials:
affiliation: UniversitaetsSpital Zuerich
name: 01 Studienregister MasterAdmins
role: STUDY_DIRECTOR
References:
citation: Hubner M, Demartines N, Muller S, Dindo D, Clavien PA, Hahnloser D. Prospective randomized study of monopolar scissors, bipolar vessel sealer and ultrasonic shears in laparoscopic colorectal surgery. Br J Surg. 2008 Sep;95(9):1098-104. doi: 10.1002/bjs.6321.
Clinical trial NCT06220708: Effects Of Dance Movement Therapy On Compassionate Flow In Nursing Students
Official title: Effects Of Dance Movement Therapy On Compassionate Flow In Nursing Students: An Experimental Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Compassion
Educational Problems
Competence
Keywords: Compassion
dance movement therapy
nursing competence
Lead sponsor: Mackay Medical College
Sponsor class: OTHER
First posted: 2024-01-24
Enrollment: 59
Sex: ALL
Minimum age (years): 19
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study aimed to investigate the differences in compassionate flow among nursing students both before and after an educational intervention.

Detailed description: Background: Only a few studies have explored how compassion is taught to nursing students.

Aim: This study aimed to investigate the differences in compassionate flow among nursing students both before and after an educational intervention.

Design: This study employed a cluster randomised controlled trial design. Settings: This study was conducted in medical schools in Taiwan. Participants: We enrolled first- and second-year nursing students. Methods: The intervention group underwent dance movement therapy, while the control group received yoga training. Compassionate flow was assessed using the Compassionate Engagement and Action Scale and the Fears of Compassion Scale.

Eligibility criteria: Inclusion Criteria:

* Freshmen or sophomore nursing students
* Those taking a course in Complementary and Alternative Therapies
* Willingness to participate and agreeing to complete the questionnaire

Exclusion Criteria:

* Deafness
* Limb disorders

Primary outcomes:
measure: Compassionate Engagement and Action Scales
timeFrame: 1 week
Secondary outcomes:
measure: Fear of Compassion Scales
timeFrame: 1 week
Other outcomes:
Locations:
city: New Taipei City
country: Taiwan
facility: Department of Nursing
Study officials:
affiliation: Department of Nursing, Mackay Medical College
name: Sheng-Miauh Huang, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06730308: Glucocorticoids Combined With Concurrent Chemoradiotherapy for Unresectable Thymoma
Official title: A Prospective, Single-arm Phase II Study of Glucocorticoids Combined With Concurrent Chemoradiotherapy for Unresectable Thymoma
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Thymoma
Keywords: Thymoma
Concurrent chemoradiotherapy
Methylprednisolone
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2024-12-12
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study aims to assess the efficacy of methylprednisolone combined with concurrent chemoradiotherapy in treating unresectable or recurrent thymoma.

Detailed description: This study aims to assess the efficacy of methylprednisolone combined with concurrent chemoradiotherapy in treating unresectable or recurrent thymoma. Patients will receive hypofractionated radiotherapy with concurrent chemotherapy.

Methylprednisolone will be administered daily during radiotherapy at a dose of 2 mg/kg.

Eligibility criteria: Inclusion Criteria:

* Histologically confirmed type AB or B1-3 thymoma.
* Measurable Disease: Patients must have measurable disease as defined by RECIST (Response Evaluation Criteria in Solid Tumors).
* Unresectable or recurrent thymoma, with the tumor confined to the chest and neck area.
* Between the ages of 18 and 70 years, regardless of sex.
* Eastern Cooperative Oncology Group performance status of 0 or 1.
* No prior chest radiation.
* Adequate organ Functions.
* Written informed consent obtained.

Exclusion Criteria:

* Contraindications to Methylprednisolone.
* History of or Concurrent Malignancy.
* Active infection, myocardial infarction within the last 6 months or symptomatic heart disease.
* Pregnant or Lactating Women.
* Bleeding Disorders.
* Recent Participation in Other Clinical Trials.
* Drug Abuse or Severe Alcoholism.
* Uncontrolled Seizures or Mental Disorders.
* Severe Allergies or Specific Sensitivities.

Primary outcomes:
measure: Objective response rate
timeFrame: 1-2 months after chemoradiotherapy
Secondary outcomes:
measure: Progression-free survival
timeFrame: 2-year
measure: Overall survival
timeFrame: 2-year
measure: Toxicities using the CTCAE 5.0
timeFrame: 1 year after treatment
measure: Quality of life scores
timeFrame: 1 year after treatment
Other outcomes:
Locations:
city: Guanzhou
country: China
facility: Sun yat-sen University Cancer Center
state: Guangdong
Study officials:
References:
Clinical trial NCT00186108: A Pilot Study Evaluating Oral Triamcinalone in Patients With Androgen Independent Prostate Cancer
Official title: A Pilot Study Evaluating Oral Triamcinalone in Patients With Androgen Independent Prostate Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Prostate Cancer
Keywords: Oral Triamcinalone
Prostate Cancer
Lead sponsor: Stanford University
Sponsor class: OTHER
Collaborators: name: United States Department of Defense
First posted: 2005-09-16
Enrollment: 23
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The primary purpose of this study is to evaluate the ability of oral triamcinalone given twice a day to patients with androgen independent prostate cancer to produce a sustained biochemical response. Secondary goals are to describe the safety and tolerability at this dose and schedule, to determine the time to sustained biochemical response, to determine the duration of biochemical response, to determine the time to disease progression.


Eligibility criteria: Inclusion Criteria:

* 18 years of age and older
* Histologically documented adenocarcinoma of prostate
* Currently receiving LHRH agonists with castrate levels of testosterone or who have had an orchiectomy
* Must have had a rise in PSA despite anti androgen withdrawal
* Exhibit 2 consecutive rise in PSA after the last hormonal manipulation
* Minimum PSA of greater than 5 KPS greater than 80%
* Normal cortisol level at entry
* Life expectancy greater than 6 months
* Provide written consent pursuant to regulatory requirements prior to initiation of study procedure

Exclusion criteria:

* Younger than 18 years
* Patients without prostate cancer

Primary outcomes:
measure: Ability of oral triamcinalone given twice a day to patients with androgen independent prostate cancer to produce a sustained biochemical response.
timeFrame: Following treatment
Secondary outcomes:
measure: Safety and tolerability at this dose and schedule, time to sustained biochemical response, duration of biochemical response, time to disease progression
timeFrame: Following treatment
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University Cancer Center
state: California
Study officials:
affiliation: Stanford University
name: Sandy Srinivas, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04937608: Impact of the Coronavirus Disease 2019 (COVID-19) on Sperm Parameters
Official title: Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection on the Sperm Parameters of Infertile Men
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Covid19
Infertility, Male
Lead sponsor: Fertilys
Sponsor class: INDUSTRY
Collaborators: name: Institut national de la recherche scientifique
First posted: 2021-06-24
Enrollment: 2
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: See Eligibility Criteria

Brief summary: This study aims to better understand the effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, virus that causes the coronavirus disease 2019 (COVID-19), on male fertility.

Detailed description: After being informed about the study and potential risks, all patients giving written informed consent will produce a sperm sample by masturbation. Patients will also complete a questionnaire relating to their state of health. Six month following the first sperm sample, patients will produce another sperm sample by masturbation. These sperm parameters will be compared with the ones from a sperm analysis performed less than 2 years before the SARS-CoV-2 infection.

Eligibility criteria: Inclusion Criteria:

* All men aged 18 to 45 having a sperm analysis done at the Fertilys fertility center in the last 2 years who have not contracted COVID-19, agreeing to participate in the study and having signed the consent form to participate in the study.
* All men aged 18 to 45 having a sperm analysis done at the Fertilys fertility center in the last 2 years) who have contracted COVID-19 within the last 6 months, agreeing to participating in the study and having signed the consent form to participate in the study.
* All men aged 18 to 45 years with a sperm concentration ≥ 15 million/mL, progressive motility ≥ 20% and a percentage of normal forms ≥ 2%.

Exclusion Criteria:

* Men aged under 18 and over 45.
* Men who cannot produce a sperm sample by antegrade ejaculation.
* Men whose sperm concentration is \<15 million/mL, progressive motility \<20% and a percentage of normal forms \<2%, determined following the production of a "reference" sperm sample, carried out before March 2020, i.e. before the COVID-19 pandemic.

Primary outcomes:
measure: Changes in sperm parameters quality
timeFrame: Pre-infection, on the day of recruitment and six month later
measure: Viral RNA in seminal plasma
timeFrame: Pre-infection, on the day of recruitment and six month later
Secondary outcomes:
Other outcomes:
Locations:
city: Laval
country: Canada
facility: Fertilys
state: Quebec
Study officials:
References:
Clinical trial NCT05014308: Effect of Piezoelectric Alveolar Decortication on Post-Orthodontic Lower Incisors Stability: A Randomized Clinical Trial
Official title: Effect of Piezoelectric Alveolar Decortication on Post-Orthodontic Lower Incisors Stability: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Retention
Keywords: Retention; Relapse; Fibrotomy; Piezocision;
Lead sponsor: King Abdulaziz University
Sponsor class: OTHER
First posted: 2021-08-20
Enrollment: 39
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: To assess the effect of piezocision on post-orthodontic lower anterior teeth stability as compared to fiberotomy and conventional Hawley retainers.


Eligibility criteria: Inclusion Criteria:

1. Individuals who had lower anterior irregularity (crowding, rotation, buccally or lingually displaced) will be selected.
2. Good oral hygiene, healthy gingiva and no evidence of bone loss as seen on the radiograph.
3. Healthy systemic conditions.
4. Patients pass the growth spurt according to cervical vertebral maturation method as described by Baccetti et al.
5. Availability of good quality records at pretreatment and post-treatment.

Exclusion Criteria:

1. Patients that has any signs of active periodontal disease or evidence of bone loss on the radiograph.
2. Patients with systemic disease such as osteoporosis and diabetes.
3. Smoking patients.
4. Study casts did not include all mandibular permanent incisors, canines, and first molars.

Primary outcomes:
measure: lower incisors stability after 6 months
timeFrame: 6 months
measure: lower incisors stability after 12 months
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: