louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05920044: Balance and Proprioception Training Program in Patients With Chronic Ankle Sprains
Official title: The Effects of an Individualized Balance and Proprioception Training Program on Pain and Function in Patients With Chronic Ankle Sprains: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Ankle Sprains
Lead sponsor: Ahram Canadian University
Sponsor class: OTHER
First posted: 2023-06-27
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To examine the effects of an individualized balance and proprioception training program on pain, function, and the risk of recurrent ankle sprains.


Eligibility criteria: Inclusion Criteria:

* Adults aged 18-55 years
* History of at least two ankle sprains within the last 12 months
* Presence of ankle instability symptoms, such as recurrent giving way or chronic pain

Exclusion Criteria:

* Acute ankle injury within the last six weeks
* Lower extremity fracture within the last six months
* Other musculoskeletal or neurological disorders affecting the lower extremity
* Inability to comply with study requirements

Primary outcomes:
measure: Changes in Pain intensity
timeFrame: Changes in Pain intensity at baseline, 8 weeks, and 16 weeks follow up
measure: Changes in Functional Ability
timeFrame: Changes in Functional ability at baseline, 8 weeks, and 16 weeks follow up
Secondary outcomes:
measure: Changes in Balance
timeFrame: Changes in balance at baseline, 8 weeks, and 16 weeks follow up
measure: Changes in Proprioception
timeFrame: Changes in proprioception at baseline, 8 weeks, and 16 weeks follow up
measure: Incidence of Recurrent Ankle Sprains
timeFrame: From post-intervention at 8 weeks to the end of the follow-up period at 16 weeks
Other outcomes:
Locations:
city: Al Ḩayy Ath Thāmin
country: Egypt
facility: Outpatient clinic of faculty of physical therapy, Ahram Canadian University
state: Giza
Study officials:
affiliation: Faculty of Physical Therapy, Ahram Canadian University
name: Amal Fawzy, Ph.d
role: STUDY_DIRECTOR
References:
Clinical trial NCT05494944: Low Power ThULEP for Prostate Size More Than 80 gm
Official title: Low Power Thulium Enucleation of Prostate More Than 80 Grams
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Benign Prostatic Hyperplasia
Lead sponsor: Kasr El Aini Hospital
Sponsor class: OTHER
First posted: 2022-08-10
Enrollment: 40
Sex: MALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Feasibility and Efficacy of lower power thulium enucleation of prostate more than 80 grams

Detailed description: Intra operative outcome and postoperative follow up of IPSS score and IEFF score at 6 months.

Eligibility criteria: Inclusion Criteria:

* BPH patients with failed medical treatment
* Refractory retention
* Hematuria
* Bladder stones
* Renal impairment due to BPH

Exclusion Criteria:

* Neurogenic patients
* stricture urethra

Primary outcomes:
measure: Timing of complete adenoma removal ( enucleation time in minutes)
timeFrame: During operation
measure: International prostate symptoms score IPSS less than 7 which is good outcome
timeFrame: 12 months
Secondary outcomes:
measure: International Index of Erectile Function- 5 score more than 12 which is a good outcome
timeFrame: 12 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Samer Morsy
Study officials:
References:
Clinical trial NCT04419844: Evaluation of TAR Technique in the Treatment of Huge Abdominal Wall Hernia and Large Abdominal Wall Defect With or Without Botox Injection .
Official title: Evaluation of TAR Technique in the Treatment of Huge Abdominal Wall Hernia and Large Abdominal Wall Defect With or Without Botox Injection .
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: TAR Technique
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2020-06-05
Enrollment: 40
Sex: ALL
Minimum age (years): 12
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aim of the work In this study, we will evaluate posterior component separation (TAR) technique with or without Botox injection for open huge ventral hernia and large abdominal wall defect repair. The primary outcome will be recurrence while the secondary outcome will be infection, postoperative complications (bleeding and dehiscence), pain score, operative time, hospitalization, need for drain, time for drain removal and pulmonary function test before and after surgery.

This prospective clinical study will be performed on 40 eligible patients admitted to general surgery department at Mansoura University Hospi


Eligibility criteria: Inclusion Criteria:

* Adult patient fit for general anesthesia with huge ventral hernia (primary, incisional or recurrent).Any patient with large abdominal wall defect secondary to abdominal wall tumor excision or burst after surgery

Exclusion Criteria:

* Patients who are unfit for general anaesthesia. Poor pulmonary function tests. Pregnant females. Patient younger than 18 years. Immunodeficiency. Patient with psychiatric disease disabling surgical intervention. Patients who refuse to participate in our study.

Primary outcomes:
measure: Recurrence
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mansoura University
state: Dakahlia
Study officials:
References:
Clinical trial NCT01451892: Dance Therapy and Obesity
Official title: The Effect of Dance Therapy on the Functional Capacity of Patients With Advanced Obesity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Keywords: Obesity
dance
gait
balance
posture
dance therapy
Lead sponsor: University Hospital, Geneva
Sponsor class: OTHER
Collaborators: name: University of Applied Sciences of Western Switzerland
First posted: 2011-10-14
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Title:

The effect of dance-therapy on the functional capacity, body image and quality of life of patients with advanced obesity

Project duration:

33 months (August 2010 to June 2013)

Clinical context:

Obesity has reached epidemic proportions. The gait and balance problems in obese people and the associated decreased functional capacity and risk of falling highlight the need to evaluate the benefits of specific treatments on these problems. Attention should be paid not only to metabolic management but also to the physical rehabilitation required in cases of advanced obesity.

Objectives:

The aim of this study is to evaluate the efficacy of dance-therapy on functional capacity (walking ability, postural control and physical activity level), body image and quality of life of patients with advanced obesity.


Eligibility criteria: Inclusion Criteria:

* Person with obesity (BMI ≥ 30)
* Aged \> 18 years old
* Being able to walk 10 meters without a walking aid

Exclusion Criteria:

* Foot ulcer at the moment of data acquisition
* Orthopaedic, surgical or neurological (other than diabetic neuropathy ) problems which af-fect patient's gait
* Non diabetic neuropathy (Charcot, chronic alcohol consumption, thyroid dysfunction)
* Mental diseases interfering with group therapies

Primary outcomes:
measure: Change in comfortable gait speed
timeFrame: 0, 36 weeks, 6 months
Secondary outcomes:
measure: Change in functional capacities
timeFrame: 0, 36 weeks, 6 months
Other outcomes:
Locations:
city: Geneva
country: Switzerland
facility: University Hospital
Study officials:
References:
citation: Allet L, Muller-Pinget S, Punt I, Edelsten C, Ballif A, Golay A, Pataky Z. Dance therapy combined with patient education improves quality of life of persons with obesity: A pilot feasibility study for a randomised controlled trial. Obes Res Clin Pract. 2017 Jan-Feb;11(1):79-87. doi: 10.1016/j.orcp.2016.03.005. Epub 2016 Apr 3.
Clinical trial NCT05441592: A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery
Official title: A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Hematoma Postoperative
Keywords: Breast reduction
Gender-affirming mastectomy
Tranexamic Acid
Lead sponsor: University of Michigan
Sponsor class: OTHER
First posted: 2022-07-01
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This trial is being completed to evaluate the safety and efficacy of topical tranexamic acid use in preventing hematomas in routine breast plastic surgery operations.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing bilateral breast reduction or bilateral gender-affirming mastectomy
* For patients undergoing bilateral breast reduction, any skin incision pattern or pedicle is acceptable.
* For patients undergoing bilateral gender-affirming mastectomy, any skin incision and mastectomy type is acceptable

Exclusion Criteria:

* Active thromboembolic disease or history of intrinsic risk of thrombosis or thromboembolism, including retinal vein or artery occlusion
* Current use of systemic anticoagulation
* Hypersensitivity to tranexamic acid
* Concomitant use of combined hormonal contraceptives
* Use of factor IX complex concentrates, anti-inhibitor coagulant concentrates or all-trans retinoic acid
* History of acquired defective color vision
* History of subarachnoid hemorrhage
* Pregnancy
* History of renal impairment or serum Creatinine \>1.5 milligrams per deciliter (mg/dL)

Primary outcomes:
measure: Incidence of Hematomas requiring operative washout or aspiration in participants that receive TXA versus participants that do not receive TXA
timeFrame: Up to approximately 4 weeks after surgery
Secondary outcomes:
measure: Number of participants experiencing a major thromboembolic event related to the study drug
timeFrame: Up to approximately 4 weeks after surgery
measure: Number of participants experiencing major complications other than hematoma
timeFrame: Up to approximately 4 weeks after surgery
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
Study officials:
affiliation: University of Michigan
name: Edwin Wilkins, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01588392: Short bouTs of Exercise for Preschool-age Children
Official title: Effects of Short Bouts of Physical Activity in Low-income Preschool-age Children
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physical Activity
Keywords: Physical activity
preschoolers
Lead sponsor: University of Massachusetts, Amherst
Sponsor class: OTHER
First posted: 2012-05-01
Enrollment: 323
Sex: ALL
Minimum age (years): 3
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to examine if short bouts of structured physical activity implemented within the classroom setting as part of designated gross-motor playtime will increase preschool-age children during-school physical activity level.

Detailed description: Most preschool centers provide two 30-minute sessions of gross-motor/outdoor playtime per preschool day. Within this time frame, children accumulate most of their activity within the first 10 minutes. This study is a cluster randomized controlled study designed to examine the effects of short bouts of structured physical activity implemented within the classroom setting as part of designated gross-motor playtime on during-school physical activity in preschoolers. Results from this intervention could provide evidence that a physical activity policy that exposes preschoolers to shorter bouts of structured physical activity throughout the preschool day could potentially increase preschooler's physical activity levels.

Eligibility criteria: Inclusion Criteria:

* Attend one of 10 participating preschool centers
* Attend preschool full-time
* Children between 2.9 - 5 years of age on the date of baseline assessment

Exclusion Criteria:

* Did not have a condition limiting their participation in routine gross-motor playtime at preschool
* Unable to wear the activity monitor

Primary outcomes:
measure: Change from baseline in Physical activity levels at 6-month
timeFrame: Baseline, 3-month and 6-month after study initiation
Secondary outcomes:
Other outcomes:
Locations:
city: Springfield
country: United States
facility: Preschool centers in Springfield, MA
state: Massachusetts
Study officials:
affiliation: University of Massachusetts, Amherst
name: Sofiya Alhassan
role: PRINCIPAL_INVESTIGATOR
References:
citation: Alhassan S, Nwaokelemeh O, Mendoza A, Shitole S, Whitt-Glover MC, Yancey AK. Design and baseline characteristics of the Short bouTs of Exercise for Preschoolers (STEP) study. BMC Public Health. 2012 Aug 1;12:582. doi: 10.1186/1471-2458-12-582.
Clinical trial NCT06549192: Autonomic Responses of Amateur Child Athletes to Aerobic Exercise Test
Official title: Autonomic Responses of Amateur Child Athletes to Aerobic Exercise Test
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Heart Rate Variability
Sport
Lead sponsor: Inonu University
Sponsor class: OTHER
First posted: 2024-08-12
Enrollment: 56
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The aim of our study was to investigate the relationship between aerobic capacity, which will be revealed by aerobic exercise test, and HRV, blood pressure, heart rate and pulmonary function parameters in healthy children interested in different sports branches (boxing, weightlifting, taekwando, swimming). The main questions it aims to answer are:

* Is there any relationship between aerobic capacity demonstrated by 20 m shuttle test and heart rate variability, blood pressure, heart rate and respiratory parameters in different sports branches?
* Is there a relationship between the month/year that children/adolescents are involved in sports and HRV, blood pressure and respiratory parameters?

Participants:

* Before the exercise test, ECG, blood pressure, heart rate and pulmonary function test will be performed.
* A 20 meter shuttle run test will be performed.
* Measurements will be repeated after the exercise test.


Eligibility criteria: Inclusion Criteria:

* 6-18 years old, registered to a club in boxing, weightlifting, taekwando and swimming (4 groups), children and adolescents who have been actively participating in their training for at least 3 months

Exclusion Criteria:

* People with neurological, orthopedic, cardiovascular diseases, those with any acute or chronic illness, smokers or drug users, elite level athletes

Primary outcomes:
measure: FVC
timeFrame: 1 hours
measure: FEV1
timeFrame: 1 hours
measure: FEV1/FVC
timeFrame: 1 hours
measure: FEF25
timeFrame: 1 hours
measure: FEF75
timeFrame: 1 hours
measure: FEF2575
timeFrame: 1 hours
measure: PEF
timeFrame: 1 hours
measure: SDNN (msn)
timeFrame: 1 hours
measure: RMSSD (msn)
timeFrame: 1 hours
measure: pNN50 (%)
timeFrame: 1 hours
measure: TP (msn²)
timeFrame: 1 hours
measure: LF (msn²), %LF, LFnorm
timeFrame: 1 hours
measure: HF (msn²), %HF, HFnorm
timeFrame: 1 hours
measure: LF/HF (msn²)
timeFrame: 1 hours
measure: Systolic blood pressure
timeFrame: 1 hours
measure: Diastolic blood pressure
timeFrame: 1 hours
measure: Heart rate per minute
timeFrame: 1 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04506892: Quantitation of Glymphatic Functioning in Sleep and Meditative States
Official title: Quantitation of Glymphatic Functioning in Sleep and Meditative States
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Parkinson Disease
Sleep
Keywords: glymphatic system
meditation
Lead sponsor: Vanderbilt University Medical Center
Sponsor class: OTHER
First posted: 2020-08-10
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: This involves development and application of magnetic resonance imaging (MRI) methods for visualizing hemodynamic and metabolic relationships in healthy volunteers with advanced meditation experience.

Detailed description: This study is evaluating the glymphatic system during awake, sleep, and meditative states.

Eligibility criteria: Inclusion Criteria:

* Ages 14-45
* "Adept meditator status"

Exclusion Criteria:

* Any non-MR compatible material implant, or contraindication to MR scanning
* Claustrophobia or inability to lie still for prolonged periods of time
* Participants with a recent (less than 2 months) infection, tattoo, or wound
* No consumption of stimulants or alcohol within 12 hours of the study visit
* clinical diagnosis of any major neurological or psychological condition
* Taking benzodiazepines, cholinestorase inhibitors, anti-psychotics, opioids, MAO inhibitors

Primary outcomes:
measure: CSF flow change
timeFrame: baseline to 24 hours
Secondary outcomes:
measure: EEG changes
timeFrame: baseline to 24 hours
Other outcomes:
Locations:
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
Study officials:
affiliation: Vanderbilt University Medical Center
name: Daniel Claassen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06718192: A Randomized Controlled Trial to Evaluate the Effectiveness of Bleomycin and Cryotherapy in Treating Plantar Warts.
Official title: A Randomized Controlled Trial to Evaluate the Effectiveness of Bleomycin and Cryotherapy in Treating Plantar Warts.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
PHASE2
Conditions: Verruca Plantaris
Keywords: verruca plantaris
Bleomycin
cryotherapy
efficiency
security
Lead sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Sponsor class: OTHER
First posted: 2024-12-05
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To evaluate the efficacy of bleomycin and cryopreservation in the treatment of plantar verruca by dermoscopy and explore the influencing factors. Compare the safety, economic burden and impact on quality of life of the two treatments

Detailed description: Our research aims to evaluate and compare the effectiveness of bleomycin and cryotherapy in treating plantar warts. First, we enrolled patients according to eligibility criteria. Second, the patients were assigned to two groups randomly. One is Bleomycin Group and the other is Cryotherapy Group which means two -group-patients were received different therapies. Thirdly, we compared the efficiency of two groups by using dermoscopy. Finnally, we used statistical analysis to analyze the research data and draw the experimental conclusions.

Eligibility criteria: Inclusion Criteria:

Age 18-65 years old, gender is not limited; Consistent with the diagnosis of plantar warts; Volunteer for treatment and sign informed consent; Consent to photograph the lesion; The treatment target area can be selected (the target area must meet the following conditions: The distance between adjacent warts in the target area is \>0.5cm; The diameter of a single wart in the target area is ≤1.5cm, and/or the diameter of a wart mass is ≤1.5cm; The number of total warts/wart masses in the target area is ≤10).

Exclusion Criteria:

Patients who can't sign informed consent; Had previously received local treatment for common warts within 1 month; hiv-positive patient; Pregnant and lactating women; Has peripheral vascular disease; Allergic to bleomycin; People who are severely immunocompromised, or who are taking immunosuppressive drugs; Mental illness or cognitive incapacity; Other conditions deemed unsuitable for inclusion, such as inability to cooperate with follow-up, were considered by the researchers.

Primary outcomes:
measure: the rate of warts complete clearance
timeFrame: 2 weeks after treatment endpoint
Secondary outcomes:
Other outcomes:
Locations:
city: Yiwu
country: China
facility: The Fourth Affiliated Hospital Zhejiang University School of Medicine
state: Zhejiang
Study officials:
References:
Clinical trial NCT00894192: Comprehensive Evaluation of Visual Function
Official title: Comprehensive Evaluation of Visual Function
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Visual Function
Keywords: This study tests functional ability of patients with refractive error or normal vision while using different types of eyeglasses.
Lead sponsor: The Chicago Lighthouse
Sponsor class: OTHER
Collaborators: name: Ophthonix Inc
name: University of Illinois at Chicago
First posted: 2009-05-06
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the level of visual functioning in patients with various eye conditions while wearing different types of eyeglasses.

Detailed description: The purpose of the research is to study the level of visual functioning in individuals with various eye conditions when using different types of eyeglass lenses. Therefore, the goal of this study is to determine factors that may account for variability in the visual functioning of individuals with a range of refractive errors and their ability to perform everyday activities when equipped with different types of lenses. We hypothesize that the subjects will perform visual tasks of function better when using iZon™ Wavefront-Guided Glasses than with conventional glasses. This hypothesis is based upon the glasses yielding better visual acuity and because the design of the glasses reduces the effects of glare. This research is important so that alternate treatments and vision correction may be implemented which will have a more beneficial impact on those with refractive errors and visual impairment.

Eligibility criteria: Inclusion Criteria:

* Have normal vision
* Are far-sighted or near-sighted
* Have no eye diseases Subjects aged 18 and over, who have refractive errors ranging from +5.0 to -5.0 and/or who have eye disease will be included in the study.

Primary outcomes:
measure: Visual Acuity, and Contrast Sensitivity
timeFrame: Once a week
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: The Chicago Lighthouse
state: Illinois
Study officials:
References: