Clinical trial NCT04689776: The Effectiveness of Dual Task Training in Elderly With Cognitive Decline
Official title: The Effectiveness of Dual Task Training in Elderly With Cognitive Decline
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Mild Cognitive Impairment
Keywords: Mild Cognitive Impairment
Cognitive Training
Exercise
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2020-12-30
Enrollment: 80
Sex: ALL
Minimum age (years): 55
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Cognitive decline is the impairment of memory, execution, or language. Early detection of the individuals who manifest cognitive decline and provide appropriate interventions may help reduce the burden of their caregivers and the medical expenses of the health-care system. Many studies have found that dual-task training combining cognitive training and exercise can improve cognitive function in older adults. However, it is yet not clear the appropriate frequency of the effective dual-task training for elderly with cognitive decline. Thus, this study aims to compare the intervention effects of high frequency sequential and low frequency dual-task training for elderly with cognitive decline.

Detailed description: Cognitive decline is the impairment of memory, execution, or language. Early detection of the individuals who manifest cognitive decline and provide appropriate interventions may help reduce the burden of their caregivers and the medical expenses of the health-care system. Many studies have found that dual-task training combining cognitive training and exercise can improve cognitive function in older adults. However, it is yet not clear the appropriate frequency of the effective dual-task training for elderly with cognitive decline. Thus, this study aims to compare the intervention effects of high frequency sequential and low frequency dual-task training for elderly with cognitive decline.

We anticipate recruiting a total of 80 participants with cognitive decline. The participants will be assigned into 2 groups: high frequency dual-task training (HF) and low frequency dual-task training (LF) groups. The participants of HF will receive a total of 36 training sessions, and each session will contain 90-120 minutes of training. The participants of LF will receive a total of 12 training sessions, and each session will contain 90-120 minutes of training. The programs are based on dual-task trainings which contain cognitive training and exercise simultaneously. For physical exercise, we will design the programs that involve balance or strength training components in the aerobic exercises. In terms of cognitive training, we will design self-made teaching aids and board games to train different domains of cognitive functions. We plan to assess the participants before and after the intervention programs. We expect that elders receiving dual-task training will improve on outcome measures, and the group with more frequency will have better performance. The results of the study will provide evidence of interventions for elderly with cognitive decline, thereby reducing the burden on their caregivers and the cost of medical resource.

Eligibility criteria: Inclusion Criteria:

* able to follow instruction (MMSE\>= 20)
* self- or informant-reported memory or cognitive complaint.

Exclusion Criteria:

* recent myocardial infarction,heart failure,recent heart surgery,
* severe asthma, concomitant with other neurological disorders, or joint deformity that might prevents them performing exercise or cognitive training.

Primary outcomes:
measure: Change scores of the Montreal Cognitive Assessment (MoCA)
timeFrame: baseline, posttest (around 12 weeks after baseline)
measure: Change scores of Mini-Mental State Exam (MMSE)
timeFrame: baseline, posttest (around 12 weeks after baseline)
measure: Change scores of the Stroop test
timeFrame: baseline, posttest (around 12 weeks after baseline)
measure: Change scores of the Timed up and go (TUG) test
timeFrame: baseline, posttest (around 12 weeks after baseline)
measure: Change scores of the Dual-task test
timeFrame: baseline, posttest (around 12 weeks after baseline)
measure: Change scores of the Wechsler Adult Intelligence Scale (WAIS)
timeFrame: baseline, posttest (around 12 weeks after baseline)
measure: Change scores of the Lawton Instrumental Activities of Daily Living Scale (IADL)
timeFrame: baseline, posttest (around 12 weeks after baseline)
measure: Change scores of the Wechsler Memory Scale (WMS)
timeFrame: baseline, posttest (around 12 weeks after baseline)
Secondary outcomes:
measure: Change scores of the Community Integration Questionnaire (CIQ)
timeFrame: baseline, posttest (around 12 weeks after baseline)
measure: Change scores of Geriatric Depression Scale (GDS)
timeFrame: baseline, posttest (around 12 weeks after baseline)
measure: Change scores of the Everyday Cognition scales (ECog)-12 items
timeFrame: baseline, posttest (around 12 weeks after baseline)
Other outcomes:
Locations:
city: Taoyuan
country: Taiwan
facility: Chang Gung Memorial Hospital
Study officials:
affiliation: Chang Gung Memorial Hospital
name: Ching yi Wu, ScD
role: PRINCIPAL_INVESTIGATOR
References: