Clinical trial NCT06885008: Effect of Video-based Game and Aerobic Exercise on Knee Osteoarthritis
Official title: The Effects of Aerobic Exercise and Active Video Games as Adjuncts to Conventional Physiotherapy on Pain, Functional Capacity, and Balance in Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteoarthritis of Knee
Keywords: Knee Osteoarthritis
Video Games
Aerobic Exercise
Pain
Disabilitiy
Lead sponsor: Hasan Kalyoncu University
Sponsor class: OTHER
Collaborators: name: The Scientific and Technological Research Council of Turkey
First posted: 2025-03-19
Enrollment: 38
Sex: ALL
Minimum age (years): 30
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This randomized controlled trial was conducted by the CONSORT guidelines for non-pharmacological treatments. Participants were randomly assigned to control, gaming, or aerobic groups using the closed-envelope randomization method. All groups received conventional physiotherapy for 8 weeks. In addition, the gaming group played active video games 3 days per week, while the aerobic group engaged in cycling-based aerobic exercise (20 minutes per session) 3 days per week. The control group received only conventional physiotherapy and continued their daily activities. Evaluations were performed by the same assessor at the baseline and after eight weeks.


Eligibility criteria: Inclusion Criteria:

* Participants, aged 30-65 years who were diagnosed with unilateral or bilateral osteoarthritis based on the clinical and radiological criteria of the American College of Rheumatology.
* The severity of osteoarthritis was classified as stage 2-3 according to the Kellgren-Lawrence grading system for gonarthrosis.
* Participants were required to be able to walk independently for at least 15 meters and to refrain from using non-steroidal anti-inflammatory drugs (NSAIDs) during the study period.

Exclusion Criteria:

* A history of lower extremity surgery within the past 6 months,
* The presence of neurological or systemic diseases,
* Other inflammatory joint diseases,
* Getting classic physiotherapy and rehabilitation within the past month,
* Intra-articular corticosteroid injections within the past 3 months,
* Severe joint deformities or movement restrictions,
* Severe visual impairments.

Primary outcomes:
measure: Knee disability
timeFrame: 8 weeks
measure: Functional capacity
timeFrame: 8 weeks
measure: Functional Performance
timeFrame: 8 weeks
measure: Balance
timeFrame: 8 weeks
Secondary outcomes:
measure: Limb strength
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Şahinbey
country: Turkey
facility: Hasan Kalyoncu University, Department of Physiotherapy and Rehabilitation
state: Gaziantep
Study officials:
affiliation: Hasan Kalyoncu University
name: Serkan Usgu, Ass Prof
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kong H, Wang XQ, Zhang XA. Exercise for Osteoarthritis: A Literature Review of Pathology and Mechanism. Front Aging Neurosci. 2022 May 3;14:854026. doi: 10.3389/fnagi.2022.854026. eCollection 2022.
citation: Cicek A, Ozdincler AR, Tarakci E. Interactive video game-based approaches improve mobility and mood in older adults: A nonrandomized, controlled tri̇al. J Bodyw Mov Ther. 2020 Jul;24(3):252-259. doi: 10.1016/j.jbmt.2020.01.005. Epub 2020 Feb 6.
citation: Oiestad BE, Aroen A, Rotterud JH, Osteras N, Jarstad E, Grotle M, Risberg MA. The efficacy of strength or aerobic exercise on quality of life and knee function in patients with knee osteoarthritis. A multi-arm randomized controlled trial with 1-year follow-up. BMC Musculoskelet Disord. 2023 Sep 8;24(1):714. doi: 10.1186/s12891-023-06831-x.
citation: Lange B, Flynn S, Proffitt R, Chang CY, Rizzo AS. Development of an interactive game-based rehabilitation tool for dynamic balance training. Top Stroke Rehabil. 2010 Sep-Oct;17(5):345-52. doi: 10.1310/tsr1705-345.