Clinical trial NCT05814627: Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis
Official title: A Phase 3b/4 Randomized, Double-Blind, Double Dummy, Active Comparator-Controlled Study, Comparing the Efficacy and Safety of Upadacitinib Versus Adalimumab in Subjects With Moderate to Severe Rheumatoid Arthritis on a Stable Background of MTX and Who Had an Inadequate Response or Intolerance to a Single TNF Inhibitor (SELECT- SWITCH)
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Rheumatoid Arthritis
Keywords: Rheumatoid Arthritis
RA
Upadacitinib
Adalimumab
Methotrexate
MTX
TNF Inhibitor
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2023-04-18
Enrollment: 487
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will assess how safe and effective upadacitinib is in treating RA when compared to adalimumab in adult participants with inadequate response or intolerance to one TNF-inhibitor who are on a stable dose of methotrexate (MTX). Adverse events and change in disease activity will be assessed.

Upadacitinib is an approved drug for the treatment of RA. This study is double-blinded means that neither the participants nor the study doctors will know who will be given upadacitinib and who will be given adalimumab. Study doctors put the participants in 1 of the 2 groups, called treatment arms randomly, to receive either upadacitinib or adalimumab. There is 1 in 2 chance that participants will receive adalimumab. Each group consists of 2 periods. Approximately 480 participants diagnosed with RA will be enrolled in approximately 250 sites across the world.

Participants will receive the oral upadacitinib once daily and matching adalimumab placebo every other week, or the subcutaneous adalimumab every other week and matching upadacitinib placebo once daily during Period 1. Eligible participants will continue to receive same study treatment in Period 2 as assigned in Period 1 and will be followed for 30 days and 70 days.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, checking for side effects and completing questionnaires.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of Rheumatoid Arthritis (RA) for \>= 3 months based on the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) classification criteria for RA.
* Treated for \>= 3 consecutive months prior to screening with 1 tumor necrosis factor inhibitor (TNFi) (only 1 of originator or biosimilar certolizumab pegol, etanercept, golimumab or infliximab) for RA, but continue to exhibit active RA, or had to discontinue due to intolerability or toxicity, irrespective of treatment duration. Up to 15% of participants who were intolerant to 1 TNFi will be allowed to enroll. Prior administration of different biosimilar versions for the same originator TNFi or switching between originator and biosimilar version of the same originator TNFi are acceptable. Cycling between biosimilars of different originator TNF inhibitors is not acceptable.
* On oral or parenteral methotrexate (MTX) therapy \>= 3 consecutive months and on a stable prescription of 15 to 25 mg/week (or \>= 10 mg/week in participants intolerant of MTX at doses \>= 15 mg/week) for \>= 4 weeks prior to the first dose of study drug. In addition, all participants should take a dietary supplement of folic acid or folinic acid throughout the study participation.

  * For a Chinese, Japanese, Korean, or Taiwanese participant, a stable dose of MTX \>= 7.5 mg/week is acceptable.
  * Additional local requirements for MTX may apply.
* Meets both of the following disease activity criteria:

  * \>= 6 swollen joint (based on 66 joint counts) and \>= 6 tender joints (based on 68 joint counts) at screening and baseline;
  * High-sensitivity C-reactive protein (hsCRP) \>= 3 mg/L (central lab, upper limit of normal \[ULN\] 2.87 mg/L) at screening.

Exclusion Criteria:

* History of any arthritis with onset prior to age 17 years or current diagnosis of inflammatory joint disease other than Rheumatoid Arthritis (RA).
* Prior exposure to any janus kinase (JAK) inhibitor.
* Prior exposure to adalimumab (original or biosimilar) or to any approved or investigational TNF inhibitor other than infliximab, etanercept, certolizumab pegol and golimumab.
* Prior exposure to an approved or investigational non-TNFi biologic disease modifying anti-rheumatic drug (bDMARD) or targeted synthetic disease modifying antirheumatic drug (tsDMARD).

Primary outcomes:
measure: Percentage of Participants Achieving Disease Activity Score 28 C-reactive Protein [DAS28-CRP]) <= 3.2
timeFrame: Week 12
Secondary outcomes:
measure: Percentage of Participants Achieving American College of Rheumatology 50 % (ACR50) Response
timeFrame: Week 12
measure: Percentage of Participants Achieving Disease Activity Score 28 C-reactive Protein [DAS28-CRP]) < 2.6
timeFrame: Week 12
measure: Change from Baseline in Disease Activity Score 28 C-reactive Protein [DAS28-CRP])
timeFrame: Week 12
measure: Change from Baseline in Participants Assessment of Pain
timeFrame: Week 12
measure: Change from Baseline in Health Assessment Questionnaire - Disability Index (HAQ-DI) Score
timeFrame: Week 12
Other outcomes:
Locations:
city: Flagstaff
country: United States
facility: AZ Arthritis and Rheumotology Research, PLLC - Flagstaff /ID# 253431
state: Arizona
city: Glendale
country: United States
facility: Arizona Arthritis and Rheumatology Research - Glendale Office /ID# 255018
state: Arizona
city: Peoria
country: United States
facility: Sun Valley Arthritis Center Ltd. /ID# 254654
state: Arizona
city: Phoenix
country: United States
facility: Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 253432
state: Arizona
city: Phoenix
country: United States
facility: Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 255021
state: Arizona
city: Tucson
country: United States
facility: Arizona Arthritis & Rheumatology Associates - Tucson /ID# 255017
state: Arizona
city: Jonesboro
country: United States
facility: Arthritis and Rheumatism Associates /ID# 254013
state: Arkansas
city: Fullerton
country: United States
facility: Providence - St. Jude Medical Center /ID# 252690
state: California
city: Huntington Beach
country: United States
facility: Newport Huntington Medical Group /ID# 252687
state: California
city: La Mesa
country: United States
facility: Purushotham & Akther Kotha MD, Inc /ID# 252704
state: California
city: Los Alamitos
country: United States
facility: Valerius Medical Group & Research Center of Greater Long Beach, Inc /ID# 252692
state: California
city: San Diego
country: United States
facility: Rheumatology Center of San Diego /ID# 255038
state: California
city: Thousand Oaks
country: United States
facility: Millennium Clinical Trials /ID# 252689
state: California
city: Torrance
country: United States
facility: The Lundquist Institute at Harbor-UCLA Medical Center /ID# 252691
state: California
city: Woodland Hills
country: United States
facility: Comprehensive Rheumatology Center /ID# 252688
state: California
city: Aurora
country: United States
facility: University of Colorado Hospital /ID# 254617
state: Colorado
city: Denver
country: United States
facility: Denver Arthritis Clinic /ID# 254058
state: Colorado
city: Fort Collins
country: United States
facility: Tekton Research - Fort Collins - East Harmony Road /ID# 255036
state: Colorado
city: Aventura
country: United States
facility: Arthritis and Rheumatic Disease Specialties /ID# 260583
state: Florida
city: Boca Raton
country: United States
facility: Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 253733
state: Florida
city: Brandon
country: United States
facility: Bay Area Arthritis and Osteo /ID# 254046
state: Florida
city: Coral Springs
country: United States
facility: Believe Clinical Trial /ID# 262355
state: Florida
city: Daytona Beach
country: United States
facility: International Medical Research /ID# 254651
state: Florida
city: DeBary
country: United States
facility: Omega Research Debary, LLC /ID# 253735
state: Florida
city: Hialeah
country: United States
facility: Neoclinical Research /ID# 254622
state: Florida
city: Hollywood
country: United States
facility: Gnp Research - Hollywood /ID# 273563
state: Florida
city: Margate
country: United States
facility: Life Clinical Trials /ID# 256061
state: Florida
city: Miami
country: United States
facility: Lakes Research, LLC /ID# 255023
state: Florida
city: Orlando
country: United States
facility: HMD Research LLC /ID# 253732
state: Florida
city: Ormond Beach
country: United States
facility: Millennium Research /ID# 253744
state: Florida
city: Palm Beach Gardens
country: United States
facility: Vitalia Research /ID# 274213
state: Florida
city: Saint Petersburg
country: United States
facility: BayCare Medical Group /ID# 253799
state: Florida
city: Tampa
country: United States
facility: Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 254649
state: Florida
city: Tampa
country: United States
facility: Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 255264
state: Florida
city: Tampa
country: United States
facility: University of South Florida- Neuroscience Institute /ID# 253745
state: Florida
city: Tampa
country: United States
facility: Baycare Medical Group - Tampa /ID# 255268
state: Florida
city: Marietta
country: United States
facility: Atlanta Research Center for Rheumatology /ID# 254623
state: Georgia
city: Chicago
country: United States
facility: Next Innovative Clinical Research - Chicago /ID# 273453
state: Illinois
city: Libertyville
country: United States
facility: Deerbrook Medical Associates /ID# 254008
state: Illinois
city: Rockford
country: United States
facility: OrthoIllinois /ID# 254057
state: Illinois
city: Schaumburg
country: United States
facility: Greater Chicago Specialty Physicians /ID# 254000
state: Illinois
city: Skokie
country: United States
facility: Clinic Of Dr. Robert Hozman/Clinical Investigation Specialists, Inc /ID# 253999
state: Illinois
city: Willowbrook
country: United States
facility: Willow Rheumatology and Wellness, PLLC /ID# 254712
state: Illinois
city: Evansville
country: United States
facility: Qualmedica Research - Evansville /ID# 254005
state: Indiana
city: Hopkinsville
country: United States
facility: Western KY Rheumatology /ID# 255026
state: Kentucky
city: Lexington
country: United States
facility: Bluegrass Community Research /ID# 254653
state: Kentucky
city: Monroe
country: United States
facility: The Arthritis & Diabetes Clinic, Inc. /ID# 254014
state: Louisiana
city: New Orleans
country: United States
facility: Ochsner Clinic Foundation /ID# 254059
state: Louisiana
city: Portland
country: United States
facility: Rheumatology Associates PA - Portland /ID# 255014
state: Maine
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center - Rheumatology /ID# 255029
state: Massachusetts
city: Grand Blanc
country: United States
facility: AA Medical Research Center - Grand Blanc /ID# 254007
state: Michigan
city: Okemos
country: United States
facility: Advanced Rheumatology, PC /ID# 256059
state: Michigan
city: Eagan
country: United States
facility: St. Paul Rheumatology, PA /ID# 255037
state: Minnesota
city: Hattiesburg
country: United States
facility: Arthritis Associates /ID# 253992
state: Mississippi
city: Kansas City
country: United States
facility: Kansas City Physician Partners /ID# 255035
state: Missouri
city: Springfield
country: United States
facility: Clinvest Research LLC /ID# 254054
state: Missouri
city: Kalispell
country: United States
facility: Logan Health Research - Glacier View Research Institute - Rheumatology /ID# 253738
state: Montana
city: Lincoln
country: United States
facility: Physician Research Collaboration, LLC /ID# 254012
state: Nebraska
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center - 1 Medical Center Drive /ID# 253798
state: New Hampshire
city: Voorhees
country: United States
facility: Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 255266
state: New Jersey
city: Las Cruces
country: United States
facility: Arthritis and Osteoporosis Associates of New Mexico /ID# 252684
state: New Mexico
city: Brooklyn
country: United States
facility: NYU Langone Ambulatory Care Brooklyn Heights /ID# 254621
state: New York
city: Charlotte
country: United States
facility: Joint And Muscle Research Institute /ID# 275128
state: North Carolina
city: Minot
country: United States
facility: Trinity Health Med Arts Clinic /ID# 254010
state: North Dakota
city: Middleburg Heights
country: United States
facility: Paramount Medical Research and Consulting /ID# 254048
state: Ohio
city: Oklahoma City
country: United States
facility: Rheumatology Associates of Oklahoma /ID# 253994
state: Oklahoma
city: Philadelphia
country: United States
facility: Clinical Research of Philadelphia, LLC /ID# 255025
state: Pennsylvania
city: Jackson
country: United States
facility: West Tennessee Research Institute /ID# 254620
state: Tennessee
city: Allen
country: United States
facility: Arthritis and Rheumatology Research Institute, PLLC /ID# 254045
state: Texas
city: Austin
country: United States
facility: Tekton Research, L.L.C /ID# 254004
state: Texas
city: Carrollton
country: United States
facility: Trinity Universal Research Associates - Carrollton /ID# 254648
state: Texas
city: Corpus Christi
country: United States
facility: Adriana Pop-Moody MD Clinic PA /ID# 255030
state: Texas
city: Fort Worth
country: United States
facility: JPS Rheumatology Clinic /ID# 254050
state: Texas
city: Houston
country: United States
facility: Biopharma Informatic - Houston - Business Center Drive /ID# 254051
state: Texas
city: Houston
country: United States
facility: Biopharma Informatic - Houston - Business Center Drive /ID# 254053
state: Texas
city: Houston
country: United States
facility: Accurate Clinical Research - Houston /ID# 254647
state: Texas
city: Katy
country: United States
facility: R & H Clinical Research - 777 Katy /ID# 255024
state: Texas
city: Lubbock
country: United States
facility: West Texas Clinical Research /ID# 253736
state: Texas
city: Plano
country: United States
facility: Trinity Universal Research Associates, Inc /ID# 253995
state: Texas
city: San Antonio
country: United States
facility: Sun Research Institute /ID# 255019
state: Texas
city: The Woodlands
country: United States
facility: Advanced Rheumatology of Houston /ID# 254003
state: Texas
city: Tomball
country: United States
facility: DM Clinical Research - Tomball /ID# 254001
state: Texas
city: Tomball
country: United States
facility: Rheumatology Clinic of Houston /ID# 254002
state: Texas
city: Franklin
country: United States
facility: Aurora Rheumatology and Immunotherapy Center /ID# 254049
state: Wisconsin
city: Glendale
country: United States
facility: Rheumatic Disease Center, LLP /ID# 254015
state: Wisconsin
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Organizacion Medica de Investigacion (OMI) /ID# 253253
state: Ciudad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Consultorios Reumatologicos Pampa /ID# 254095
state: Ciudad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Aprillus Asistencia e Investigacion /ID# 253258
state: Ciudad Autonoma De Buenos Aires
city: San Miguel de Tucuman
country: Argentina
facility: Centro de Investigaciones Medicas Tucuman /ID# 253297
state: Tucuman
city: San Miguel de Tucuman
country: Argentina
facility: CIMER Centro Integral de Medicina Respiratoria /ID# 255277
state: Tucuman
city: Genk
country: Belgium
facility: ReumaClinic /ID# 252277
state: Limburg
city: Gent
country: Belgium
facility: UZ Gent /ID# 252306
state: Oost-Vlaanderen
city: Brugge
country: Belgium
facility: AZ Sint-Jan Brugge /ID# 252278
city: Liege
country: Belgium
facility: CHU de Liege /ID# 252309
city: Juiz de Fora
country: Brazil
facility: CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 254203
state: Minas Gerais
city: Curitiba
country: Brazil
facility: CETI - Centro de Estudos em Terapias Inovadoras /ID# 254201
state: Parana
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre /ID# 254916
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: LMK Sevicos Medicos S/S /ID# 254202
state: Rio Grande Do Sul
city: Sao Jose Do Rio Preto
country: Brazil
facility: Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 254917
state: Sao Paulo
city: Sao Paulo
country: Brazil
facility: CEPIC - Centro Paulista de Investigacao Clinica /ID# 254200
city: Plovdiv
country: Bulgaria
facility: Umbal Kaspela /ID# 252343
city: Plovdiv
country: Bulgaria
facility: Medical center Unimed /ID# 252344
city: Plovdiv
country: Bulgaria
facility: MHAT Plovdiv /ID# 252342
city: Sofia
country: Bulgaria
facility: Diagnostic consultative center 17 Sofia /ID# 252341
city: Sofia
country: Bulgaria
facility: Military Medical Academy Multiprofile Hospital /ID# 252355
city: Sofiya
country: Bulgaria
facility: Diagnostic consultative center Focus-5 /ID# 252354
city: Sofiya
country: Bulgaria
facility: Diagnostic consultative center Focus-5 /ID# 252555
city: Winnipeg
country: Canada
facility: Manitoba Clinic /ID# 254019
state: Manitoba
city: Rimouski
country: Canada
facility: Centre Rhumatologie de l'Est /ID# 254932
state: Quebec
city: Sainte-foy
country: Canada
facility: Groupe de Recherche en Maladies Osseuses Inc /ID# 253409
state: Quebec
city: Trois-rivières
country: Canada
facility: Centre de Recherche Musculo-Squelettique /ID# 256273
state: Quebec
city: Saskatoon
country: Canada
facility: Dr. Latha Naik Medical Professional Corporation /ID# 254018
state: Saskatchewan
city: Osorno
country: Chile
facility: Corporacion de Beneficiencia Osorno /ID# 252556
state: Los Lagos
city: Santiago
country: Chile
facility: Complejo Asistencial Dr. Sotero del Rio /ID# 252559
state: Region Metropolitana De Santiago
city: Santiago
country: Chile
facility: Centro Internacional de Estudios Clinicos - CIEC /ID# 252561
state: Region Metropolitana Santiago
city: Vitacura
country: Chile
facility: Clinica Dermacross /ID# 252560
state: Region Metropolitana Santiago
city: Bengbu
country: China
facility: The first affiliated hospital of bengbu medical college /ID# 252612
state: Anhui
city: Beijing
country: China
facility: Peking University First Hospital /ID# 252392
state: Beijing
city: Beijing
country: China
facility: Peking University Third Hospital /ID# 252393
state: Beijing
city: Guangzhou
country: China
facility: The Third Affiliated Hospital, Sun Yat-Sen University /ID# 252394
state: Guangdong
city: Zhuzhou
country: China
facility: Zhuzhou Central Hospital /ID# 252390
state: Hunan
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital /ID# 252613
state: Jiangsu
city: Pingxiang
country: China
facility: Jiangxi Pingxiang People's Hospital /ID# 252381
state: Jiangxi
city: Chengdu
country: China
facility: West China Hospital, Sichuan University /ID# 252364
state: Sichuan
city: Medellín
country: Colombia
facility: Hospital Pablo Tobón Uribe /ID# 253371
state: Antioquia
city: Barranquilla
country: Colombia
facility: Centro Integral de Reumatología del Caribe SAS - Circaribe SAS /ID# 252587
state: Atlantico
city: Bogotá
country: Colombia
facility: Centro de Investigacion en Reumatologia y especialidades Medicas S.A.S- CIREEM /ID# 252586
state: Cundinamarca
city: Zipaquirá
country: Colombia
facility: Healthy Medical Center S.A.S /ID# 252585
state: Cundinamarca
city: Bucaramanga
country: Colombia
facility: Fundacion Oftalmologica de Santander - FOSCAL /ID# 252589
state: Santander
city: Zagreb
country: Croatia
facility: Medical Center Kuna-Peric /ID# 252452
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Poliklinika Bonifarm /ID# 252741
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Poliklinika Repromed /ID# 252451
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Poliklinika Solmed /ID# 252453
state: Grad Zagreb
city: Krapinske Toplice
country: Croatia
facility: Specijalna bolnica za medicinsku rehabilitaciju Krapinske Toplice /ID# 252455
city: Nice CEDEX 1
country: France
facility: Centre Hospitalier Universitaire de Nice Hopital Pasteur /ID# 254224
state: Alpes-Maritimes
city: TOULOUSE Cedex 9
country: France
facility: CHU Toulouse - Hopital Purpan /ID# 252402
state: Haute-Garonne
city: Montpellier
country: France
facility: CHU Montpellier - Hôpital Lapeyronie /ID# 252386
state: Herault
city: Amiens CEDEX 1
country: France
facility: CHU Amiens-Picardie Site Sud /ID# 252384
state: Somme
city: Orléans
country: France
facility: Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 252385
city: Rouen
country: France
facility: Hôpital Charles-Nicolle /ID# 252908
city: Templin
country: Germany
facility: Rheumatologische-Immunologische Praxis Templin /ID# 252863
state: Brandenburg
city: Herne
country: Germany
facility: Rheumazentrum Ruhrgebiet /ID# 252670
state: Nordrhein-Westfalen
city: Hamburg
country: Germany
facility: MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH /ID# 252667
city: Planegg
country: Germany
facility: Klinische Forschung im med. Versorgungsalltag GbR /ID# 254221
city: Ratingen
country: Germany
facility: Rheumazentrum Ratingen /ID# 252669
city: Athens
country: Greece
facility: General Hospital of Athens Laiko /ID# 252258
state: Attiki
city: Athens
country: Greece
facility: University General Hospital Attikon /ID# 254751
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 252261
state: Kriti
city: Veszprém
country: Hungary
facility: Vital Medicina Kft /ID# 252399
state: Veszprem
city: Budapest
country: Hungary
facility: Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 253311
city: Szekesfehervar
country: Hungary
facility: CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 252400
city: Szolnok
country: Hungary
facility: MÁV Kórház /ID# 252628
city: Florence
country: Italy
facility: Azienda Ospedaliero Universitaria Careggi /ID# 252460
state: Firenze
city: Milan
country: Italy
facility: ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO /ID# 252461
state: Milano
city: Ancona
country: Italy
facility: Azienda Ospedaliero Universitaria delle Marche /ID# 252459
city: Nagoya-shi
country: Japan
facility: Japan Organization of Occupational Health and Safety Chubu Rosai Hospital /ID# 252836
state: Aichi
city: Nagoya-shi
country: Japan
facility: Daido Clinic - Nagoya /ID# 253058
state: Aichi
city: Kashiwa-shi
country: Japan
facility: Kashiwa Kousei General Hospital /ID# 270033
state: Chiba
city: Fukui-shi
country: Japan
facility: Sugimoto Rheumatology and Internal Medicine Clinic /ID# 252774
state: Fukui
city: Fukuoka-shi
country: Japan
facility: Hamanomachi Hospital /ID# 253168
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Shono Rheumatism Clinic /ID# 252591
state: Fukuoka
city: Asahikawa-shi
country: Japan
facility: Katayama Orthopedic Rheumatology Clinic /ID# 252746
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sagawa Akira Rheumatology Clin /ID# 252773
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Hokkaido Medical Center For Rheumatic Diseases /ID# 270019
state: Hokkaido
city: Kato-shi
country: Japan
facility: Matsubara Mayflower Hospital /ID# 252834
state: Hyogo
city: Sanuki-shi
country: Japan
facility: Sanuki Municipal Hospital /ID# 252747
state: Kagawa
city: Kochi-shi
country: Japan
facility: Bay Side Misato Medical Center /ID# 252661
state: Kochi
city: Kumamoto shi
country: Japan
facility: Kumamoto Orthopaedic Hospital /ID# 253167
state: Kumamoto
city: Miyazaki-shi
country: Japan
facility: Medical Corporation Keiai Kai Clinic /ID# 252750
state: Miyazaki
city: Sasebo-shi
country: Japan
facility: Sasebo Chuo Hospital /ID# 252662
state: Nagasaki
city: Izumisano-shi
country: Japan
facility: Rinku Hashimoto Rheumatology Orthopaedics /ID# 270396
state: Osaka
city: Chuo-ku
country: Japan
facility: St.Luke's International Hospital /ID# 253131
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Keio University Hospital /ID# 253205
state: Tokyo
city: Shimonoseki-shi
country: Japan
facility: Tokito Clinic Rheumatology and Orthopaedics Surgery /ID# 253057
state: Yamaguchi
city: Oita
country: Japan
facility: Maeshima Rheumatology Clinic /ID# 270448
city: Toyama
country: Japan
facility: Toyama Prefectural Central Hospital /ID# 270871
city: Cheonan-si
country: Korea, Republic of
facility: SoonChunHyang University Hospital Cheonan /ID# 254942
state: Chungcheongnamdo
city: Daejeon
country: Korea, Republic of
facility: Chungnam National University Hospital /ID# 252159
state: Daejeon Gwang Yeogsi
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Bitgoeul Hospital /ID# 254802
state: Gwangju Gwang Yeogsi
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital /ID# 252160
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Hanyang University Seoul Hospital /ID# 252161
state: Seoul Teugbyeolsi
city: Mexico City
country: Mexico
facility: CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 252873
state: Ciudad De Mexico
city: Mexico City
country: Mexico
facility: Hospital de Jesus /ID# 253114
state: Distrito Federal
city: Guadalajara
country: Mexico
facility: Centro Integral en Reumatologia S.A de C.V /ID# 252872
state: Jalisco
city: Guadalajara
country: Mexico
facility: Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 253480
state: Jalisco
city: Chihuahua
country: Mexico
facility: Investigacion y Biomedicina de Chihuahua /ID# 253115
city: Almada
country: Portugal
facility: Hospital Garcia de Orta /ID# 252491
state: Setubal
city: Ponte de Lima
country: Portugal
facility: Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 252489
state: Viana Do Castelo
city: Lisboa
country: Portugal
facility: Unidade Local de Saude de Santa Maria, EPE /ID# 252492
city: San Juan
country: Puerto Rico
facility: GCM Medical Group PSC /ID# 252700
city: San Juan
country: Puerto Rico
facility: Mindful Medical Research /ID# 252693
city: Timisoara
country: Romania
facility: Cabinet Medical Dr. Avram S.R.L /ID# 254133
state: Timis
city: Timisoara
country: Romania
facility: Banat Carina Med SRL /ID# 252757
state: Timis
city: Bacau
country: Romania
facility: Spitalul Judetean de Urgenta Bacau /ID# 252860
city: Bucuresti
country: Romania
facility: Spitalul Clinic Sf. Maria /ID# 252759
city: Bucuresti
country: Romania
facility: Spitalul Clinic Sf. Maria /ID# 253334
city: Belgrade
country: Serbia
facility: Institute for Rheumatology /ID# 252333
state: Beograd
city: Belgrade
country: Serbia
facility: Institute for Rheumatology /ID# 252334
state: Beograd
city: Belgrade
country: Serbia
facility: Institute for Rheumatology /ID# 252335
state: Beograd
city: Belgrade
country: Serbia
facility: Institute for Rheumatology /ID# 252338
state: Beograd
city: Novi Sad
country: Serbia
facility: Special Hospital for Rheuma /ID# 252336
state: Vojvodina
city: Novi Sad
country: Serbia
facility: Special Hospital for Rheuma /ID# 252339
state: Vojvodina
city: Pretoria
country: South Africa
facility: University of Pretoria /ID# 252368
state: Gauteng
city: Pretoria
country: South Africa
facility: Dr Elsa van Duuren /ID# 252387
state: Gauteng
city: Pretoria
country: South Africa
facility: Emmed Research cc /ID# 254317
state: Gauteng
city: Umhlanga
country: South Africa
facility: Dr Asokan Naidoo /ID# 252894
state: Kwazulu-Natal
city: Cape Town
country: South Africa
facility: Winelands Medical Research - Somerset West /ID# 252745
state: Western Cape
city: Cape Town
country: South Africa
facility: Arthritis Clinical Research Trials /ID# 252370
state: Western Cape
city: Stellenbosch
country: South Africa
facility: Winelands Medical Research Centre /ID# 252369
state: Western Cape
city: Santiago de Compostela
country: Spain
facility: Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 252430
state: A Coruna
city: Villajoyosa
country: Spain
facility: Hospital Marina Baixa /ID# 254141
state: Alicante
city: Badalona
country: Spain
facility: Hospital Universitario Germans Trias i Pujol /ID# 254144
state: Barcelona
city: Sabadell
country: Spain
facility: Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 252425
state: Barcelona
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe /ID# 254143
city: London
country: United Kingdom
facility: Royal Free Hospital /ID# 252297
state: Greater London
city: Kings Lynn
country: United Kingdom
facility: The Queen Elizabeth Hospital, Kings Lynn NHS Foundation Trust /ID# 252301
state: Norfolk
city: London
country: United Kingdom
facility: Queen Mary University of London /ID# 252671
city: Portsmouth
country: United Kingdom
facility: Portsmouth Hospitals University NHS Trust /ID# 252772
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: