Clinical trial NCT00609414: Albumin Use in Burn Patients
Official title: Albumin Use in Burn Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Burns
Keywords: Burns
Albumin
Fluid Resuscitation
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
First posted: 2008-02-07
Enrollment: 460
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who have 20% and greater Total Body Surface Area burns who received fluid resuscitation for these injuries.

Brief summary: This is a study of why and how physicians use albumin during the first 72 hours after a burn injury.

Detailed description: While albumin has been a part of burn resuscitation for many years, its use remains varied and controversial. The purpose of this study is to describe the current practices of albumin administration during the first 72 hours after a burn injury. Participating sites will collect data on patients with at least a 20% Total Body Surface Area (TBSA) burn. Information will be recorded on type and extent of burn injury, basic demographic data, co-morbidities, outcomes and, for the first 72 hours post injury, if albumin was used and why, amount of resuscitation fluids and urine output, and use of vasopressors and diuretics.

Each participating site will retrospectively review 20 charts of consecutive admissions with at least a 20% TBSA burn. In addition, each site will collect data prospectively on 20 more patients with 20% TBSA burns. Prospective data is requested in order to capture as close as possible to "real time" the reasons physicians choose to give albumin. No Protected Health Information (PHI) will be recorded.

Data will be analyzed for patterns of albumin use and reasons for albumin administration.

Eligibility criteria: Inclusion Criteria:

* Burn Injury, with and without inhalation injury

Exclusion Criteria:

* \<20% Total Body Surface Area Burned
* Comfort care only for the burn injury

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Arizona Burn Center, Maricopa Medical Center
state: Arizona
city: San Francisco
country: United States
facility: Bothin Burn Center, Saint Francis Memorial Hospital
state: California
city: Gainesville
country: United States
facility: Shands at the University of Florida Burn Center
state: Florida
city: Augusta
country: United States
facility: Joseph M Still Research Foundation Inc and Doctors Hospital of Augusta
state: Georgia
city: Kansas City
country: United States
facility: Bothin Burn Center, University of Kansas Hospital
state: Kansas
city: St. Paul
country: United States
facility: Regions Hospital Burn Center
state: Minnesota
city: Chapel Hill
country: United States
facility: North Carolina Jaycee Burn Center, University of North Carolina Hospitals
state: North Carolina
city: Akron
country: United States
facility: Paul and Carol David Foundation Burn Institute, Akron Children's Hospital
state: Ohio
city: Cincinnati
country: United States
facility: Shriners Hospitals for Children
state: Ohio
city: Portland
country: United States
facility: Oregon Burn Center, Legacy Health System
state: Oregon
city: Salt Lake City
country: United States
facility: University of Utah Hospitals Burn Center
state: Utah
city: Toronto
country: Canada
facility: Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre
state: Ontario
Study officials:
affiliation: North Carolina Jaycee Burn Center, University of North Carolina Hospitals
name: Bruce A. Cairns, MD
role: PRINCIPAL_INVESTIGATOR
References: