Clinical trial NCT05391620: The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation
Official title: Acute Effects of the 3/7 Method and 3X9 Method in Resistance Training on Testosterone, Glucocorticoid Cortisol, Growth Hormone and Lactate in Heart Failure and Coronary Artery Disease During Cardiac Rehabilitation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Failure
Resistance Training
Coronary Artery Disease
Keywords: Cardiac rehabilition
exercise therapy
metabolic stress
Lead sponsor: Université Libre de Bruxelles
Sponsor class: OTHER
First posted: 2022-05-26
Enrollment: 25
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population.

3/7 method consisting of five sets of an increasing number of repetitions (3 to 7) during successive sets and brief inter-set intervals (15 s). This method is compare to 3X9 method, 3 series of 9 repetitions with inter-set (1min).The training exercise consisted of contraction on machine (leg press, triceps press, leg curl, traction, leg extension) with load of \~ 70% of one repetition maximal (1RM).

Before these trainings all subject perform HIIT on bicycles (2 min high intensity (80% Wmax) and 2 min low intensity (50% Wmax) during 30 minutes.

The investigators collect blood sample before exercice, after HIIT and after RT.

It is randomized cross-over study.

Detailed description: The subjects come on two different days minimum 2 days and maximum 10 days between the two tests. They were instructed to avoid exercise the day before they participated in the study.

The investigators collect blood 2 minutes after endurance training (HIIT) and 2 min after RT training.

Eligibility criteria: Inclusion Criteria:

* Clinical Coronary artery diseases
* Heart failure with reduced ejection fraction

Exclusion Criteria:

* angina
* acutely decompensated heart failure
* electrocardiographic evidence of ischemia
* significant valvular disease
* orthopedic/neurologic disorders that limited exercise

Primary outcomes:
measure: Change in Lactate
timeFrame: within 2 minutes after TR training session on day 1
measure: change in Testosterone
timeFrame: within 2 minutes after TR training session on day 1
measure: change Glucocorticoid Cortisol
timeFrame: within 2 minutes after TR training session on day 1
measure: change in Growth Hormone
timeFrame: within 2 minutes after TR training session on day 1
measure: change in ph
timeFrame: within 2 minutes after TR training session on day 1
measure: change PCO2 venoust
timeFrame: within 2 minutes after TR training session on day 1
Secondary outcomes:
measure: Borg scale
timeFrame: within 4 minutes after TR training session on day 1
measure: Pleasure of the session scale
timeFrame: within 4 minutes after TR training session on day 1
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Erasme Hospital
Study officials:
affiliation: Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium
name: Philippe van de borne, Professor
role: STUDY_DIRECTOR
References:
citation: Mang ZA, Realzola RA, Ducharme J, Bellissimo GF, Beam JR, Mermier C, de Castro Magalhaes F, Kravitz L, Amorim FT. The effect of repetition tempo on cardiovascular and metabolic stress when time under tension is matched during lower body exercise. Eur J Appl Physiol. 2022 Jun;122(6):1485-1495. doi: 10.1007/s00421-022-04941-3. Epub 2022 Apr 8.