louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01649973: Study for Appropriate Operating Table Height for Endotracheal Intubation Under Direct Laryngoscopy
Official title: Study for Appropriate Operating Table Height for Endotracheal Intubation Under Direct Laryngoscopy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Larynx
Lead sponsor: National Medical Center, Seoul
Sponsor class: OTHER
First posted: 2012-07-25
Enrollment: 8
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: certificated anesthesiologists

Brief summary: Laryngeal view of the patient and anesthesiologist's discomfort level during endotracheal intubation in relation to the various heights of operating table has not been investigated. The investigators hypothesis is higher table height will improve the laryngeal exposure.

Detailed description: Eight anesthesiologists will be participated. For each anesthesiologist, 20 patients will be enrolled and they will be randomly allocated into one of 4 groups; T10, T8, T6 or T4. The height of operating table will be adjusted prior to commencement of anesthesia induction to place the patient's forehead at one of four anesthesiologist's dermatome levels (T10, T8, T6 or T4) depending on the group. The best laryngeal views will be graded before and after the anesthesiologist's postural change to improve laryngeal visualization of the patient during intubation. Subjective and objective measurement of anesthesiologists' joint flexion during intubation and discomfort ratings for the mask ventilation or intubation will be recorded.

Eligibility criteria: Inclusion Criteria:

* have experiences of more than 100 cases of endotracheal intubation

Exclusion Criteria:

* have acute or chronic musculoskeletal disease or pain

Primary outcomes:
measure: larynx
timeFrame: larynx
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: National Medical Center, Seoul
name: Mija Yun
role: STUDY_CHAIR
References:
citation: Lee HC, Yun MJ, Hwang JW, Na HS, Kim DH, Park JY. Higher operating tables provide better laryngeal views for tracheal intubation. Br J Anaesth. 2014 Apr;112(4):749-55. doi: 10.1093/bja/aet428. Epub 2013 Dec 18.
Clinical trial NCT01024673: Clinical Characteristics and Outcomes in Patients Diagnosed With Novel Influenza A (H1N1)
Official title: Clinical Characteristics and Outcomes in Patients Diagnosed With Novel Influenza A (H1N1)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Influenza
Keywords: H1N1
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
First posted: 2009-12-03
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients diagnosed clinically with H1N1

Brief summary: This is study where medical record information will be collected as well as collection of excess biological samples.

Detailed description: Patients diagnosed with H1N1 will be asked to consent and allow us to collect the following:

From the medical record the research staff will review and record the results of the test/procedures (x-rays, CT-scans, EKG (electrocardiogram), etc.) that are part of the subjects clinical care and the results will become part of the research record. We will also collect and record vitals signs, including temperature, blood pressure, heart rate, respiratory rate and record the list of medications the subject is taking. We will also collect information on demographics (address, phone number, etc.) including gender, race and ethnicity, review and record past medical history and any non medical procedures that the subject may have had within the past two months. This information will be collected by the research coordinator from the medical record.

The clinical physician ordered a nasopharyngeal swab or obtained bronchoalveolar lavage fluid to diagnose novel Influenza A (H1N1). We will collect this swab or fluid after the diagnosis has been made, to evaluate the genetic material of the virus. This swab or fluid is normally discarded once the diagnosis is made.

collection of data will be done by the research staff and should not take any longer than 15-20 minutes. The clinical samples that would have been discarded will be collected by the research staff from microbiology and pathology and delivered to the research lab in Scaife.

The investigators will do a 6 month follow up phone call to check the health status of the participant. This will be done by the research coordinator and take no more than 5-10 minutes of the subject's time.

Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with H1N1

Exclusion Criteria:

* does not meet entry criteria

Primary outcomes:
measure: To describe the clinical characteristic and outcomes of the patients admitted to UPMC Presbyterian campus with infection due to novel influenza A (H1N1).
timeFrame: 5 year
Secondary outcomes:
measure: To identify risk factors for admission to the ICU and mortality
timeFrame: 5 years
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: UPMC
state: Pennsylvania
Study officials:
affiliation: University of Pittsburgh
name: Fernanda Silveira, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05198973: Bumblebee Breath Effect on Tinnitus in Older Patients
Official title: Bumblebee Breath Effect on Tinnitus in Older Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Tinnitus, Subjective
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-01-20
Enrollment: 56
Sex: ALL
Minimum age (years): 65
Maximum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Tinnitus is a condition in which the person hears sound, which isn't coming from the external environment, often, described as ringing in the ears.

Patients describe the condition as an annoyance and disturbance and in turn this correlates with increased levels of anxiety and depression. Currently, there is no single effective treatment for tinnitus so research continues to look for new ways to treat and manage the condition.

Bumblebee Breath starts by finding a relaxed, supported posture, either laying supine or in seated and then bringing the minds attention to the space between the eyebrows (or third eye in yoga terms). With the eyes close the thumbs are placed over the tragus of the ears, the first finger gently rests on eye lids, middle finger touches the sides of the nose and then the index and pinkie rest just above and below the closed lips. Next, a sound is created by inhaling deeply through the nose and exhaling with a low-pitched humming sound. The result sounds very much like a bee buzzing to the person performing the breath and a sensation of vibration is experienced inside the head and over the face. this study is designed to assess Bumblebee Breath on tinnitus.

Detailed description: two groups (28 for each) will included. One tinnitus group will receive half an hour of Bumblebee Breath training (daily) for one month. The second one will receive nothing

Eligibility criteria: Inclusion Criteria:

* elderly males and females
* Tinnitus complaints

Exclusion Criteria:

* cardio(respiratory) symptoms, any local (within ear) problem(s).

Primary outcomes:
measure: Tinnitus Handicap Inventory
timeFrame: week 4
Secondary outcomes:
measure: visual analogue scale for tinnitus annoyance
timeFrame: week 4
measure: visual analogue scale for tinnitus loudness
timeFrame: week 4
measure: pulse rate
timeFrame: week 4
measure: respiratory rate
timeFrame: week 4
measure: systolic blood pressure
timeFrame: week 4
measure: diastolic blood pressure
timeFrame: week 4
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Cairo Unoversity
Study officials:
affiliation: Cairo University
name: Ali Ismail, lecturer
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00032773: Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD
Official title: A Sequentially Adaptive, Open Label, Dose-finding, Phase I/II Trial of Pentostatin in the Treatment of Steroid-refractory Acute Graft Versus Host Disease (aGvHD)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE1
PHASE2
Conditions: Acute Graft Versus Host Disease
Keywords: acute graft versus host disease
aGVHD
allogeneic hematopoietic stem cell transplantation
peripheral blood stem cell transplantation
cord blood transplant
pentostatin
Nipent
deoxycoformycin
Lead sponsor: Astex Pharmaceuticals, Inc.
Sponsor class: INDUSTRY
First posted: 2002-04-04
Enrollment: 36
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To determine a safe and effective dose of pentostatin in steroid-refractory aGvHD and to identify the minimal effective dose of pentostatin defined as the lowest dose that produces a response in 20% or more of patients while producing treatment failure (defines as death, grade 3/4 toxicity, or progressive disease) in 40% or less of patients.


Eligibility criteria: Inclusion:

* Patients 6 months of age with grade 2 GVHD that is steroid-refractory
* Must be engrafted with ANC 1000/mL, may still be transfusion dependent for platelets and PRBC
* Time post stem cell infusion \< 100 days
* Written informed consent
* Must have adequate renal function (creatinine clearance 40 mL/min/1.73 m2)

Exclusion:

* Post-transplant lymphoproliferative disease
* Uncontrolled infection
* Mental illness or other condition preventing full cooperation with the treatment and monitoring requirements of the study
* ATG within the previous 14 days
* Other immunosuppressive agents (including monoclonal antibodies) when initiated within the previous 7 days

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: MD Anderson Cancer Center
state: Texas
Study officials:
References:
Clinical trial NCT02120573: Efficacy of CPR Teaching in Mass Training
Official title: Evaluation of Teaching Methods in Mass CPR Training in Different Groups of the Society
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Teaching CPR
Keywords: Cardiac Arrest
Cardiopulmonary Resuscitation
Training
Lead sponsor: Shiraz University of Medical Sciences
Sponsor class: OTHER
Collaborators: name: Shiraz education development center
First posted: 2014-04-22
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL

Brief summary: This prospective study evaluate teaching efficacy of CPR training using different methods in general population, medical students and non medical students with the 12 months evaluation of its recall

Detailed description: In a prospective and observational study of 2000 individuals in three different groups including medical students, non-medical students and general populations four different protocols of CPR training were applied and their efficacy were compared between the groups. Meanwhile, 12 months after the study course, 460 participants from three groups were asked to take part in a theoretical and practical exam to evaluate the long term efficacy of the four protocols.

Eligibility criteria: Inclusion Criteria:

* all participant take part in workshop

Exclusion Criteria:

* refuse to take part in exams

Primary outcomes:
measure: teaching efficacy
timeFrame: 24 hours
measure: late post workshop practical test
timeFrame: 12 months
Secondary outcomes:
measure: trainee satisfaction
timeFrame: 24 hours
Other outcomes:
Locations:
city: Shiraz
country: Iran, Islamic Republic of
facility: Shiraz University of Medical Sciencs
state: Fars
Study officials:
References:
citation: Hasani H, Bahrami M, Malekpour A, Dehghani M, Allahyary E, Amini M, Abdorahimi M, Khani S, Kalantari Meibodi M, Kojuri J. Evaluation of Teaching Methods in Mass CPCR Training in Different Groups of the Society, an Observational Study. Medicine (Baltimore). 2015 May;94(21):e859. doi: 10.1097/MD.0000000000000859.
Clinical trial NCT02691273: Applicability of Cellular Application in Diabetes Type 2 Patients.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetes Mellitus, Type 2
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2016-02-25
Enrollment: 9
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: It was found that an important part of the factors impeding adherence to medication and a healthy lifestyle among the chronically ill diabetic patients lies in proper management of the disease. Since it is a chronic progressive disease the caregiver is the patient himself.Studies have shown that software system, sending text messages / messages / reminders daily and answering questionnaires can improve adherence to a change in lifestyle.

This study is an initial pilot study , which examines Feasibility ( Applicability ) of using a smart application that promotes a healthy lifestyle perseverance parallel use relaxation techniques .


Eligibility criteria: Inclusion Criteria:

* HbA1c above 7.5.
* Smartphone users.
* English and Hebrew literate.

Exclusion Criteria:

\*Pregnancy

Primary outcomes:
measure: 10 percentage improvement in the quality of life questionnaire
timeFrame: two months
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
Study officials:
affiliation: Hadassah Medical Organization
name: Avivit Cohen
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06878573: Change in Ocular Perfusion After Intravitreal Anti-VEGF in Patients with Age-related Maculopathy or Diabetic Macula Edema
Official title: Description of the Changes of Ocular Perfusion in Patients with Age-related Maculopathy or Diabetic Macula Edema After Intravitreal Aflibercept Injection Treatment
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Age Related Macular Degeneration
Diabetic Macular Edema
Keywords: ocular perfusion
laser speckle flowgraphy
anti-VEGF
Lead sponsor: Augenabteilung Allgemeines Krankenhaus Linz
Sponsor class: OTHER
First posted: 2025-03-17
Enrollment: 36
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Caucasian patients scheduled for intravitreal Aflibercept because of age related macular degeneration or diabetic macular edema

Brief summary: This prospective study will include patients with neovascular age-related macular degeneration or diabetic macular edema, scheduled for intravitreal aflibercept. Ocular perfusion will be measured by Laser Speckle Flowgraphy (LSFG). The parameter Mean Blur Rate (MBR) reflects erythrocyte flow velocity and serves as an indirect marker of perfusion. MBR will be measured at the optic nerve head (ONH). The devices software can analyze MBR in areas of major retinal vessels (MV) and in microperfusion areas (MT) separately. Measurements will be conducted on the day of the planned intravitreal injection and one and four weeks post-injection.


Eligibility criteria: Inclusion Criteria:

* age \> 50 years,
* patients scheduled for an intravitreal injections with Aflibercept for treatment of DME or AMD.

Exclusion Criteria:

* ocular surgery (including intravitreal injection) during the 3 months preceding the study
* Ametropia \> 6 Dpt
* any relevant ophthalmic diseases/conditions that could interfere with LSFG measurements (e.g. glaucoma, optic nerve head drusen, tilted disc, etc.).

Primary outcomes:
measure: Mean blur rate in retinal vessels (MV)
timeFrame: Baseline; Week 1; Week 4;
Secondary outcomes:
Other outcomes:
Locations:
city: Linz
country: Austria
facility: Department for Ophthalmology
state: Upper Austria
Study officials:
References:
Clinical trial NCT06059573: The Accuracy of Dental Implant Placement Using Robotic System-assisted Surgery and Freehand Surgery
Official title: The Accuracy of Dental Implant Placement Using Robotic System-assisted Surgery and Freehand Surgery: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dental Implant
Keywords: robot-guided surgery
freehand
dental implant robot
accuracy
Lead sponsor: Hospital of Stomatology, Wuhan University
Sponsor class: OTHER
First posted: 2023-09-28
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: We plan to conduct this randomized clinical trial to compare the implant positional accuracy of robotic system-assisted implant surgery with that of conventional freehand implant surgery. Patients will be enrolled and randomly assigned to either an experimental group that underwent robotic surgery or a control group that underwent freehand surgery, to evaluate the accuracy of implant in both groups.

Detailed description: Oral implants have become a widely used treatment modality for patients with missing or edentulous teeth. Previous studies have shown that implant accuracy is associated with implant success and long-term outcomes. Therefore, we plant to conduct this randomized clinical trial to compare the implant positional accuracy of robotic system-assisted implant surgery with that of conventional freehand implant surgery. Patients will be enrolled and randomly assigned to either an experimental group that underwent robotic surgery or a control group that underwent freehand surgery. By comparing the preoperative planned implant position with the actual postoperative implant position using CBCT, we will evaluate the accuracy of implant in both groups.

Eligibility criteria: Inclusion Criteria:

1. Single missing teeth with adjacent and opposing healthy natural teeth;
2. Healthy patients;
3. Sufficient alveolar bone available for implant placement.

Exclusion Criteria:

1. Pregnancy or intention to become pregnant at any point during the study duration
2. With any systemic diseases/conditions that are contraindications to dental implant...

Primary outcomes:
measure: Implant positional accuracy
timeFrame: immediately after surgery
Secondary outcomes:
measure: Surgery complication
timeFrame: Immediately and seven days after surgery
Other outcomes:
Locations:
city: Wuhan
country: China
facility: School & Hospital of Stomatology, Wuhan University
state: Hubei
Study officials:
affiliation: School & Hospital of Stomatology, Wuhan University
name: Qi Yan, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: School & Hospital of Stomatology, Wuhan University
name: Yufeng Zhang, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT00596973: Surgical Treatment of Type 2 Diabetes in Non-Morbidly Obese Patients
Official title: Phase IV Study of Surgical Treatment of Type 2 Diabetes in Non-Morbidly Obese Patients
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Diabetes
Lead sponsor: Medtronic - MITG
Sponsor class: INDUSTRY
First posted: 2008-01-17
Enrollment: 0
Sex: ALL
Minimum age (years): 35
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The aim of this study is to assess the short term success and feasibility of ileal transposition with sleeve gastrectomy in non-morbidly obese patients with poorly controlled Type 2 Diabetes Mellitus


Eligibility criteria: Inclusion Criteria:

1. Diagnosed Type 2 Diabetes for 3 to 5 years.
2. Poorly controlled blood sugar despite standard of care\* as demonstrated by HbA1c 8-11 for at least 6 months and 3 office visits. Standard of care is based on the ADA (American Diabetes Association) guidelines which include nutrition, exercise, education, behavior modification and pharmacological treatment. A co-investigator endocrinologist will ensure that the above standard of care has been met.
3. BMI between 25.0 and 34.4.
4. Stable weight as determined by no more than a 3% change in body weight in the last 3 months.
5. Age between 35 and 65 (both men and women will be included).
6. Able to provide Informed Consent.
7. Able to comply with follow-up procedures.

Exclusion Criteria:

1. Previous history of major abdominal surgery which may lead to a hostile abdomen.
2. Pregnancy
3. Patients who have an incurable malignant or debilitating disease
4. Serious uncorrectable impairment of coagulation (INR\>1.4, PTT \> + 3 secs), lungs, kidney or heart
5. Diagnosed severe eating disorder
6. Use of medication for weight loss in the last 6 months
7. Untreated endocrine disorder
8. Active peptic ulcer
9. Untreated H. pylori
10. Cognitive Impairment
11. Diabetic autonomic neuropathy
12. Symptomatic gastroparesis

Primary outcomes:
measure: Treatment sucess based on patients' glycemic control
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Mount Sinai School of Medicine
state: New York
Study officials:
affiliation: Icahn School of Medicine at Mount Sinai
name: Barry Salky, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05048173: Sentinel Lymph Node Biopsy Versus Lymphadenectomy in Endometrial Cancer
Official title: Sentinel Lymph Node Biopsy Versus Pelvic Lymphadenectomy in Early Stage Endometrial Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Early Stage Endometrial Cancer
Sentinel Lymph Nodes
Lymphadenectomy
Lead sponsor: Far Eastern Memorial Hospital
Sponsor class: OTHER
First posted: 2021-09-17
Enrollment: 334
Sex: FEMALE
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women aged 20 and above, diagnosed with early stage endometrial cancer (FIGO stage I), who had received staging surgery between 01 July 2017 and 19 August 2021 were included in the study.

Brief summary: To compare sentinel lymph nodes biopsy versus comprehensive lymphadenectomy in patients with early stage endometrial cancer.

Detailed description: This retrospective study aims to compare sentinel lymph nodes biopsy versus comprehensive lymphadenectomy in patients with early stage endometrial cancer by reviewing the medical records.

Eligibility criteria: Inclusion Criteria:

* ≧ 20 years
* early stage endometrial cancer (FIGO stage I)

Exclusion Criteria:

* Did not receive a complete course of treatment in this hospital, interrupted the treatment halfway (except if the disease continued to deteriorate or caused death during treatment), and did not follow up in this hospital after the course of treatment.

Primary outcomes:
measure: progression free survival
timeFrame: 4 years
measure: overall survival
timeFrame: 4 years
Secondary outcomes:
measure: surgical complications related to lymph node biopsy or lymphadenectomy
timeFrame: from the day of operation till post-operative 6 months
Other outcomes:
Locations:
city: Banqiao
country: Taiwan
facility: Department of Obstetrics and Gynecology, Far-Eastern Memorial Hospital
state: New Taipei
Study officials:
References: