Clinical trial NCT00855023: Knee Alignment Contributions to Anterior Cruciate Ligament (ACL) Injury
Official title: Tibiofemoral Alignment: Contributing Factors to Noncontact Anterior Cruciate Ligament Injury
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Knee Injuries
Keywords: anterior cruciate ligament
Knee Joint
Lead sponsor: The Orthopaedic Center, Maryland
Sponsor class: OTHER
First posted: 2009-03-03
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: healthy volunteer athletes and excluded those who had any of the following criteria: 1) counter-indications to magnetic resonance imaging (e.g., pregnancy or postsurgical hardware \[plates, screws, aneurysm clip, implanted cardiac pacemaker, etc.\]); (2) relevant medical problems (e.g., connective tissue problems, paralyzed hemidiaphragm, morbid obesity, claustrophobia, etc.); (3) clinical signs of an impairment or abnormality in the knee (e.g., abnormal range of motion, muscle weakness, or malalignment); (4) injury to the knee that required medical attention; (5) previous surgery on the knee; or (6) current pain in the knee.

Brief summary: This study evaluates the the anatomic factors of the knee that may predispose to ACL injury.

Detailed description: Despite intense study of anterior cruciate ligament injury during the past three decades, the mechanisms of this injury have not been clearly defined. A recent study by the Principle Investigator identified differences in leg alignment when a single leg landing during a sports activity resulted in a torn ACL and when it did not (provocative versus control alignment, respectively).

The purpose of the study is to quantify the tibiofemoral alignment in the lateral compartment of the knee in the provocative landing position and the control landing position. in order to elucidate possible mechanisms of ACL injury Material and Methods: 25 normal controls will be recruited from the greater Washington DC population. Magnetic resonance images in the sagittal plane will be acquired for a single leg of each subject. These images will cover the lateral compartment of the knee and will be acquired with the leg in three positions, one that emulates the injury position, one that exagerrates the injury position, and one that emulates the control landing position. Statistical analysis of the measurements between the provocative, exagerrated provocative, and control positions will then be performed.

These insights could then be applied to improving training focused on reducing the incidences of ACL rupture; improving bracing designs to help athletes most at risk of ACL rupture or those recovering from ACL injury/surgery; and improving ACL replacement surgeries.

Eligibility criteria: Inclusion Criteria:

* Healthy controls
* Ages 18-45 years old

Exclusion Criteria:

* Previous knee injury or surgery
* Metal implants in body

Primary outcomes:
measure: Measurement of anatomy of knee
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Rockville
country: United States
facility: Open MRI of Washington
state: Maryland
Study officials:
affiliation: The Orthopedic Center
name: Barry P Boden, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Boden BP, Torg JS, Knowles SB, Hewett TE. Video analysis of anterior cruciate ligament injury: abnormalities in hip and ankle kinematics. Am J Sports Med. 2009 Feb;37(2):252-9. doi: 10.1177/0363546508328107.
citation: Boden BP, Breit I, Sheehan FT. Tibiofemoral alignment: contributing factors to noncontact anterior cruciate ligament injury. J Bone Joint Surg Am. 2009 Oct;91(10):2381-9. doi: 10.2106/JBJS.H.01721.