Clinical trial NCT04627220: The Effect of Arterial Oxygen Parameters on Antioxidant Parameters
Official title: The Effect of Arterial Oxygen Levels on Thiol Disulfide Homeostasis and Ischemia Modified Albumin in Coronary Artery Bypass Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Diseases
Keywords: cardiovascular surgery
antioxidant
tiyol-disülfid homeostasis
ischemia modified albumin
Lead sponsor: Bursa Yüksek İhtisas Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2020-11-13
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 128 patients scheduled for cardiac surgery

Brief summary: We aimed to measure the changes in your blood values caused by different but safe oxygen values used by us during your heart surgery under laboratory conditions.

Detailed description: Hyperoxia is often preferred due to the risk of tissue hypoxia that may develop in cardiac surgery. It is thought that with hyperoxemia, ischemia reperfusion damage increases, microcirculation is impaired and tissue oxygenation is impaired.Oxidative damage occurs in cases of increased oxidative stress and impaired antioxidant balance.It was aimed to investigate oxidative damage by recording modified albumin and thiol disulfide in blood simultaneously by recording arterial oxygen levels at determined times during cardiac surgery.

Eligibility criteria: Inclusion Criteria:

* patient scheduled for cardiac surgery
* ASA\>3
* Aged 18-75 years

Exclusion Criteria:

* those with valvular disease
* EF\<%40
* BMI\>40 kg/m2
* presence of arrhythmia that impairs hemodynamics
* previous history of cerebrovascular
* diagnosed with end-stage organ failure

Primary outcomes:
measure: assessment of oxidative damage
timeFrame: 48 hours after operation
Secondary outcomes:
Other outcomes:
Locations:
city: Bursa
country: Turkey
facility: University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital
Study officials:
affiliation: Bursa Yüksek İhtisas Education and Research Hospital
name: Ümran K Karaca, md
role: PRINCIPAL_INVESTIGATOR
affiliation: Bursa Yüksek İhtisas Education and Research Hospital
name: Tuğba O Onur, MD
role: STUDY_DIRECTOR
affiliation: Bursa Yüksek İhtisas Education and Research Hospital
name: Şeyda Ö Özgünay, MD
role: STUDY_DIRECTOR
affiliation: Bursa Yüksek İhtisas Education and Research Hospital
name: Filiz A Ata, MD
role: STUDY_DIRECTOR
affiliation: Bursa Yüksek İhtisas Education and Research Hospital
name: Canan Y Yılmaz, MD
role: STUDY_DIRECTOR
affiliation: Bursa Yüksek İhtisas Education and Research Hospital
name: Şermin E Eminoğlu, MD
role: STUDY_DIRECTOR
affiliation: Bursa Yüksek İhtisas Education and Research Hospital
name: Halil Erkan S Sayan, MD
role: STUDY_DIRECTOR
affiliation: Bursa Yüksek İhtisas Education and Research Hospital
name: Yasemin Ü Üstündağ, MD
role: STUDY_DIRECTOR
affiliation: Bursa Yüksek İhtisas Education and Research Hospital
name: Anıl O Onur, MD
role: STUDY_DIRECTOR
References: