Clinical trial NCT07022860: Study on Platelet-Rich Fibrin for Preserving Jawbone After Tooth Extraction Using CBCT Imaging in Adults
Official title: Radiographic Assessment of the Effects of Platelet-Rich Fibrin on Socket Preservation: A Case-Control Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Socket Preservation
Lead sponsor: Zahedan University of Medical Sciences
Sponsor class: OTHER
First posted: 2025-06-15
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The goal of this clinical trial is to learn if platelet-rich fibrin (PRF), a substance made from a person's own blood, helps preserve the bone in the jaw after tooth extraction in adults. The main questions it aims to answer are:

Does PRF help reduce the loss of bone height after tooth removal? Does PRF improve how much of the socket fills with new bone?

Researchers will compare extraction sites treated with PRF to untreated sites in the same person to see if PRF helps preserve more bone.

Participants will:

Have two teeth removed on opposite sides of the mouth Receive PRF in one socket, while the other socket is left to heal naturally Undergo 3D X-ray scans (CBCT) right after extraction and again 3 months later

This study will help researchers understand if using PRF alone can improve healing and reduce bone loss after tooth extraction.


Eligibility criteria: Inclusion Criteria:

Participants were eligible for inclusion if they met the following criteria:

* Age ≥ 18 years
* Smoking fewer than 10 cigarettes per day
* Presence of adequate bony support (≥ 60%)
* Indications for bilateral tooth extraction
* Patients classified as ASA I or II (American Society of Anesthesiologists).
* No systemic conditions known to impair healing, including the following:

  * Use of bisphosphonates
  * Anticoagulant or antiplatelet therapy
  * History of head and neck radiotherapy
  * Chronic use of NSAIDs or corticosteroids

Exclusion Criteria:

Patients were excluded if they met any of the following conditions:

* ASA classification III or IV
* Pregnancy or lactation
* Presence of active infection at the surgical site or need for medications beyond standard analgesics
* Presence of chronic lesions at the extraction site (patients requiring curettage of the lesion were included; those with acute infection requiring antibiotics were excluded).

Primary outcomes:
measure: Change in Vertical Ridge Height from Baseline to 3 Months Post-Extraction as Measured by Cone-Beam Computed Tomography (CBCT)
timeFrame: Immediately post-extraction (baseline) and at 3 months post-extraction
Secondary outcomes:
measure: Change in Horizontal Ridge Width at 1 mm, 3 mm, and 5 mm Apical to the Crest from Baseline to 3 Months Post-Extraction Measured by CBCT
timeFrame: Immediately post-extraction (baseline) and at 3 months post-extraction
measure: Percentage of Socket Fill at 3 Months Post-Extraction as Measured by CBCT
timeFrame: 3 months post-extraction
Other outcomes:
Locations:
city: Zahedan
country: Iran, Islamic Republic of
facility: Zahedan University of Medical Sciences
state: Sistan & Balouchestan
Study officials:
References: