Clinical trial NCT06621381: Concentrated Exposure and Response Prevention for Children With Obsessive-compulsive Disorder
Official title: A Single Group Evaluation of Concentrated Exposure and Response Prevention for Children With Obsessive-compulsive Disorder
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Obsessive-Compulsive Disorder
Keywords: Obsessive-compulsive disorder
Exposure
Response prevention
Pediatric
Cognitive Behavioral Therapy
Lead sponsor: Uppsala University Hospital
Sponsor class: OTHER
Collaborators: name: Uppsala University
First posted: 2024-10-01
Enrollment: 20
Sex: ALL
Minimum age (years): 6
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to evaluate the preliminary outcomes of concentrated exposure and response prevention for children with obsessive-compulsive disorder (OCD) in regular clinical practice. It is a non-randomised open label evaluation where children 6-12 years with OCD who are patients at the Child and Adolescent Psychiatry (CAP) at Uppsala University Hospital will be rectruited together with their legal guardians. The treatment will be delivered by trained therapists in regular outpatient care.

The main question the study aims to answer is:

What are the preliminary treatment effects of concentrated exposure and response prevention with regards to OCD-symptoms, functional impact, family accomodation and clinician ratings of severity and improvement?

Participants will receive psychoeducation (in group format) and exposure and response prevention (9-12h concentrated to one week, individual format).

Outcomes will be measured on structured interviews, clinician ratings, and validated questionnaires pre-treatment, post-treatment and at a six month follow-up.


Eligibility criteria: Inclusion Criteria:

* The patient fulfills the diagnostic criteria of obsessive-compulsive disorder
* The patient and the legal guardians have said yes to receiving the concentrated exposure with response prevention - treatment

Exclusion Criteria:

* The patient/legal guardians are unable to communicate in Swedish

Primary outcomes:
measure: Childrens Yale-Brown Obsessive-Compulsive Scale (CY-BOCS)
timeFrame: pre-intervention; one week after the intervention; six months after the intervention
Secondary outcomes:
measure: Clinical Global Impression (CGI)
timeFrame: pre-intervention; one week after the intervention; six months after the intervention
measure: Dimensional Obsessive-Compulsive Scale - Child Version (DOCS-CV)
timeFrame: pre-intervention; one week after the intervention; six months after the intervention
measure: The Obsessive Compulsive Inventory-Child Version (OCI-CV)
timeFrame: pre-intervention; one week after the intervention; six months after the intervention
measure: Dimensional Obsessive-Compulsive Scale - Parent Version (DOCS-PV)
timeFrame: pre-intervention; one week after the intervention; six months after the intervention
measure: The Family Accommodation Scale for Obsessive Compulsive Disorder - Self-Rated Version (FAS-SR)
timeFrame: pre-intervention; one week after the intervention; six months after the intervention
Other outcomes:
Locations:
city: Uppsala
country: Sweden
facility: Uppsala University Hospital
state: Region Uppsala
Study officials:
affiliation: Uppsala University Hospital
name: Vendela Zetterqvist, Ph D, Associate Professor
role: PRINCIPAL_INVESTIGATOR
References: