Clinical trial NCT03495076: Perceptual Distortions in Acute Neck Pain
Official title: Perceptual Distortions in Acute Neck Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neck Pain, Posterior
Pain, Acute
Keywords: Tactile acuity
Tactile dysfunction
Sensory dissociation
Two-point discrimination
Perception
Lead sponsor: The Jerzy Kukuczka Academy of Physical Education in Katowice
Sponsor class: OTHER
Collaborators: name: University of Luebeck
First posted: 2018-04-11
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: Within-group designed study. All participants will be assessed in three different experimental conditions (control, saline injection, sham injection). The order of conditions will be counterbalanced across participants and randomly chosen.
Primary purpose: BASIC_SCIENCE

Brief summary: Research has shown that chronic pain is related to variety of perceptual distortions. Little is known on how acute pain experience influences perception, especially precision of touch. This project is aiming to test the hypothesis of pain as a process of biological value leading to improvement in tactile acuity.

Detailed description: This project has following goals:

1. To test the hypothesis of pain as a process of biological value leading to improvement in tactile acuity
2. To investigate intra-rater reliability of tests measuring perceptual distortions in pain
3. To investigate validity of novel tests measuring perceptual distortions in pain
4. To explore the influence of acute neck pain on left/right recognition task
5. To explore the effect of acute neck pain on body perception

Eligibility criteria: Inclusion Criteria:

* Only participants without tactile dysfunction will be included.
* Participants reporting availability during the days in which the research will be performed.

Exclusion Criteria:

* current pain experience
* episodes of neck
* thoracic or lumbar pain lasting more than 24 hours within previous month
* history of chronic pain, i.e. pain lasting more than three-month period
* comorbidities affecting nervous system
* cardio-vascular diseases
* psychiatric illnesses
* any disease requiring systematic drug consumption
* diagnosed scoliosis.

Primary outcomes:
measure: Tactile acuity measured by two-point discrimination test (TPD).
timeFrame: TPD change from baseline at 30 seconds post-manipulation period (e.g. saline injection).
Secondary outcomes:
measure: Laterality judgements measured by left/right recognition application.
timeFrame: Measured at baseline and ~30 seconds after manipulation (e.g. saline injection).
measure: Sensory dissociation measured by two-point estimation task (TPE).
timeFrame: Measured at baseline and ~30 seconds after manipulation (e.g. saline injection).
Other outcomes:
measure: Pain intensity measured behaviourally on a Numerical Rating Scale (NRS).
timeFrame: Pain intensity will be measured just after saline/sham injection and every 10 seconds after this time point up until 30 seconds.
measure: Distribution of pain measured by estimating the diameter of the circle representing area affected by pain.
timeFrame: Pain distribution will be measured just after saline/sham injection and every 10 seconds after this time point up until 30 seconds.
measure: Fear of pain measured on a Numerical Rating Scale (NRS)
timeFrame: Fear of pain (state) measured only at baseline
measure: Fear of Pain Questionnaire (FPQ-III).
timeFrame: Measured only at baseline.
measure: Pain duration
timeFrame: One measurement collected immediately after pain alleviation. The time frame will vary from person to person, however it is expected to collect the data an average 10 minutes after the injection.
Locations:
city: Katowice
country: Poland
facility: The Jerzy Kukuczka Academy of Physical Education
Study officials:
affiliation: The Jerzy Kukuczka Academy of Physical Education, Department of Physiotherapy
name: Wacław M Adamczyk, MSc
role: STUDY_DIRECTOR
References:
citation: Adamczyk WM, Saulicz O, Saulicz E, Luedtke K. Tactile acuity (dys)function in acute nociceptive low back pain: a double-blind experiment. Pain. 2018 Mar;159(3):427-436. doi: 10.1097/j.pain.0000000000001110.
citation: Adamczyk WM, Luedtke K, Saulicz O, Saulicz E. Sensory dissociation in chronic low back pain: Two case reports. Physiother Theory Pract. 2018 Aug;34(8):643-651. doi: 10.1080/09593985.2017.1423431. Epub 2018 Jan 11.
citation: Adamczyk W, Luedtke K, Saulicz E. Lumbar Tactile Acuity in Patients With Low Back Pain and Healthy Controls: Systematic Review and Meta-Analysis. Clin J Pain. 2018 Jan;34(1):82-94. doi: 10.1097/AJP.0000000000000499.
citation: Harvie DS, Edmond-Hank G, Smith AD. Tactile acuity is reduced in people with chronic neck pain. Musculoskelet Sci Pract. 2018 Feb;33:61-66. doi: 10.1016/j.msksp.2017.11.009. Epub 2017 Nov 21.
citation: Elsig S, Luomajoki H, Sattelmayer M, Taeymans J, Tal-Akabi A, Hilfiker R. Sensorimotor tests, such as movement control and laterality judgment accuracy, in persons with recurrent neck pain and controls. A case-control study. Man Ther. 2014 Dec;19(6):555-61. doi: 10.1016/j.math.2014.05.014. Epub 2014 Jun 10.