Clinical trial NCT03233282: EEG Monitoring for PERFormance Anticipation
Official title: Electrophysiological and Bioenergetic Study of Variations in Cognitive and Physical Performance in Healthy Humans: EEG Monitoring for PERFormance Anticipation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2017-07-28
Enrollment: 169
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Identify, characterize and then validate electrophysiological markers linking electrophysiological cerebral activity and performance in cognitive and physical fatigability in humans. To do this, noninvasive explorations of electroencephalography (EEG) and magnetoencephalography (MEG) will be carried out under two conditions of different experiments, the first one that induces a cognitive fatigability and the second one that induces physical fatigability.


Eligibility criteria: Inclusion Criteria MGPFco group:

* Adult subjects, male or female, right-handed or left-handed, from 18 years up to 70 years;
* Having duly completed the entire confidential medical questionnaire;
* Written consent of free, informed and express participation;
* No hearing problems;
* Having normal or corrected vision;
* Affiliation to a Social Security scheme.

Inclusion Criteria MGPFph group:

* Adult subjects, male or female, right-handed or left-handed, from 18 years up to 35 years;
* Practicing at least five hours of sports per week;
* Presenting a certificate of no contraindication to an exercise test, intense sports practice or an energy sport in competition of the current year;
* Having duly completed the entire confidential medical questionnaire;
* Without cardiovascular or motor disability;
* Without tumoral, inflammatory, cardiac, pulmonary, renal, digestive (malabsorption syndrome) or liver disease;
* Written consent of free, informed and express participation;
* Affiliation to a Social Security scheme.

Exclusion Criteria:

* Pregnant women, nursing mothers or those of childbearing age without contraception
* Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of liberty or of liberty
* Persons protected by the law
* Persons who have performed a maximum stress test within 15 days of the date of inclusion,
* In the course of drug treatments against indicated for the protocol (treatment for neurological diseases, psychiatric ...).
* Metal implants incompatible with MRI (for the subjects concerned, see appendices)
* Metallic implants incompatible with the MEG (for the subjects concerned, see appendices)

Primary outcomes:
measure: Identify electrophysiological markers in humans depending on whether the experimental conditions induce cognitive fatigability.
timeFrame: 7 hours
measure: Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with EEG.
timeFrame: 7 hours
measure: Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with MEG.
timeFrame: 7 hours
Secondary outcomes:
measure: Refine (locate at the level of the cortex), the origin of these physiological markers
timeFrame: 7 hours
measure: Distinguish between different time scales of performance
timeFrame: 7 hours
Other outcomes:
Locations:
city: Bron
country: France
facility: Hospices Civils de Lyon, HFME
Study officials:
affiliation: Hospices Civils de Lyon
name: Julien JUNG, MD
role: PRINCIPAL_INVESTIGATOR
References: