Clinical trial NCT05478460: Acute and Chronic Pain After Video-assisted Thoracoscopic Surgery for Lung Cancer
Official title: Acute and Chronic Pain After Video-assisted Thoracoscopic Surgery for Lung Cancer in Patients With Preoperative CT-guided Hookwire Localization
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Cancer
Keywords: Lung cancer
Video-assisted Thoracoscopic Surgery
hookwire location
Lead sponsor: Fudan University
Sponsor class: OTHER
First posted: 2022-07-28
Enrollment: 161
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The institutional review board approved this prospective study. This study included 138 consecutive patients who underwent CT-guided localization before VATS , of which 69 using hookwire (Group A) and 69 without hookwire (Group B). The inclusion criteria were as follows: patients were planned to underwent VATS for lung cancer .

Brief summary: The aim of this study is to evaluate whether preoperative CT- guided hookwire localization would influence the incidence and intensity of acute and chronic pain after VATS.

Detailed description: Postoperative pain after thoracic surgery has gained recognition as a adverse outcome and head-scratching problem. The incidence of choric postoperative pain (CPSP) in thoracic surgery has been reported to be 20%-80%. However, there has been not an standard treatment for CPSP. Many study has showed the risk factors of CPSP in thoracic surgery, such as VATS type, operation time, duration of drainage, preoperative pain, repeat surgery, gender, postoperative chemotherapy or radiation therapy , etc. It is important that moderate-to-severe acute postoperative pain will be transformed into CPSP. That offers a new management goal in postoperative pain prevention.CT-guided hookwire localization have been proven to be benefical for VATS to diagnose and treat small pulmonary , it can shorten operation timing and increase surgery success rate. However, it causes roughly 23.8% severe pain and complaints included wire dislodgement, pneumothorax and haemorrhage during and after insertion. The question is whether or not the moderate-to-severe acute postoperative pain from hookwire localition will change the incidence and intensity of CPSP in VATS.

Nurses play a pivotal role in advanced practice, research, and education in the field of pain management. The pain management of hookwire localization may be a new vison in further research.

Eligibility criteria: Inclusion Criteria:

* Aged 18-75
* patients who underwent underwent CT-guided localization before VATS
* ASA I-II
* BMI 18.5-30
* no serious complications after localization
* sign informed consent

Exclusion Criteria:

* could not complish underwent CT-guided localization
* selfexpression or visual dysfunction
* having emergency surgery
* a severe psychiatric illness
* having chronic pain problems in the chest area
* Pregnant women

Primary outcomes:
measure: postoperative incidence and intensity of chronic pain after surgery
timeFrame: at postoperative 3rd month
measure: postoperative incidence and intensity of chronic pain after surgery
timeFrame: at postoperative 6th month
Secondary outcomes:
measure: postoperative length of stay in hospital
timeFrame: an average of 1 week
measure: satisfactory score
timeFrame: from the day discharge from hospital to postoperative 6th month
measure: intensity of postoperative acute pain
timeFrame: from immediately after surgery(at postanesthesia care unit ) to postoperative 2nd day
Other outcomes:
Locations:
city: Shanghai
country: China
facility: 270 Dongan Road, Fudan University Shanghai Cancer Center
Study officials:
affiliation: Department of Anesthesiology, Fudan University Shanghai Cancer Center;
name: Jun Zhang, PhD
role: PRINCIPAL_INVESTIGATOR
References: