Clinical trial NCT01093482: Third International Study on Mechanical Ventilation
Official title: Third Prospective, Observational, International, Multicenter Study on Mechanical Ventilation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Respiratory Failure
Keywords: mechanical ventilation
epidemiology
outcomes
mortality
weaning
sedation
non-invasive positive pressure ventilation
Lead sponsor: Hospital Universitario Getafe
Sponsor class: OTHER
First posted: 2010-03-25
Enrollment: 8151
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Mechanically ventilated patients

Brief summary: The objective of this study is to obtain a better understanding of the spectrum of use of mechanical ventilation in intensive care units:

1. Main analysis: To know the all-cause mortality rate in mechanically ventilated patients
2. Secondary analyses:

   * To know the current status of mechanical ventilation in the intensive care unit and determine the number and percentage of patients who are admitted to an intensive care unit and require mechanical ventilation.
   * To compare the results with prior data collected in previous observational studies (1998 and 2004)
   * Non-invasive positive pressure ventilation
   * Weaning
   * Use of adjuvant therapies as steroids or selective digestive decontamination
   * Sedation including prevalence of delirium in mechanically ventilated patients
   * Prediction of the duration of mechanical ventilation
   * Other

Detailed description: Mechanical ventilation is commonly used in patients admitted to intensive care units. Clinical studies have investigated some of the aspects associated with its utilization, and have contributed to improve the knowledge and management of patients with acute respiratory failure. In 1998 the invesgtigators conducted the first international study on mechanical ventilation, including 5183 patients who were mechanically ventilated longer than 12 hours (Esteban A. JAMA 2002). Six years later, the investigators carried out the second international study on mechanical ventilation including 4968 patients. These studies allowed us to analyze the evolution of mechanical ventilation and to judge the concordance of practice with results of randomized trials (Esteban A. Am J Respir Crit Care 2008). The main finding of this study was the high degree of concordance between observed changes in mechanical ventilation practice and changes predicted from reports of randomized controlled trials. However, despite apparently beneficial changes in ventilatory practice, the investigators were not able to detect significant differences in clinical outcomes over this time period. Our results serve as an updated benchmark on the usual care and outcomes of mechanically ventilated patients in a 'real-world' setting.

The investigators now propose to conduct a third international study of mechanical ventilation, 6 years after the 2nd study and 12 years after the original. This will again be a prospective, multicenter single-cohort study, which will enroll consecutive patients who have received mechanical ventilation for at least 12 hours during a 1-month period, and will follow each patient for the duration of mechanical ventilation, up to 28 days. With this 3rd study the investigators aim: 1) to determine if the observed changes that the investigators reported previously are maintained over time; 2) to evaluate if the changes implemented have impacted outcomes; 3) to analyze some aspects related to withdrawal of mechanical ventilation; and implementation non-invasive positive pressure ventilation; and 4) to evaluate what differences may occur between geographical areas.

Eligibility criteria: Inclusion Criteria:

* Patients who are admitted to the intensive care unit and require invasive mechanical ventilation (endotracheal tube or tracheostomy) for more than 12 hours.
* Patients who are admitted to the intensive care unit and require non-invasive mechanical ventilation (BIPAP or CPAP with nasal or facial mask) for more than 1 hour.

Exclusion Criteria:

* Patients less than 18 years old

Primary outcomes:
measure: All-cause Mortality
timeFrame: At day 28 after the beginning of mechanical ventilation
Secondary outcomes:
Other outcomes:
Locations:
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics
state: Iowa
city: Louisville
country: United States
facility: University of Louisville School of Medicine
state: Kentucky
city: Boston
country: United States
facility: Boston Medical Center
state: Massachusetts
city: Springfield
country: United States
facility: Baystate Medical Center
state: Massachusetts
city: Detroit
country: United States
facility: Henry Ford Hospital Detroit
state: Michigan
city: Omaha
country: United States
facility: Omaha VA Medical Center
state: Nebraska
city: Morristown
country: United States
facility: Morristown Medical Center
state: New Jersey
city: Newark
country: United States
facility: UMDNJ-New Jersey Medical School
state: New Jersey
city: New York
country: United States
facility: The Mount Sinai Medical Center
state: New York
city: New York
country: United States
facility: Bronx Lebanon Hospital Center
state: New York
city: New York
country: United States
facility: New York Methodist Hospital
state: New York
city: Oklahoma City
country: United States
facility: Oklahoma City VA Medical Center
state: Oklahoma
city: Oklahoma City
country: United States
facility: Oklahoma University Health Science Center & VA medical Center
state: Oklahoma
city: Nashville
country: United States
facility: Vanderbilt University School Of Medicine
state: Tennessee
city: Galveston
country: United States
facility: University Of Texas Medical Branch at Galveston
state: Texas
city: San Antonio
country: United States
facility: University Hospital San Antonio and South Texas Veterans Health Care System
state: Texas
city: Temple
country: United States
facility: Temple Clinic, Scott & White Healthcare
state: Texas
city: Milwaukee
country: United States
facility: Medical College Of Wisconsin
state: Wisconsin
city: Bahía Blanca
country: Argentina
facility: Hospital Naval Puerto Belgrano
city: Buenos Aires
country: Argentina
facility: Clinica Bazterrica
city: Buenos Aires
country: Argentina
facility: Clínica Santa Isabel
city: Buenos Aires
country: Argentina
facility: Hospital A. Posadas
city: Buenos Aires
country: Argentina
facility: Hospital Churruca-Visca
city: Buenos Aires
country: Argentina
facility: Hospital Español
city: Buenos Aires
country: Argentina
facility: Hospital General de Agudos Bernardino Rivadavia
city: Buenos Aires
country: Argentina
facility: Hospital General de Agudos Dalmacio Vélez Sársfield
city: Buenos Aires
country: Argentina
facility: Hospital General de Agudos donación Francisco Santojanni
city: Buenos Aires
country: Argentina
facility: Hospital General de Agudos Juan A. Fernandez
city: Buenos Aires
country: Argentina
facility: Hospital General de Agudos P. Piñeiro
city: Buenos Aires
country: Argentina
facility: Hospital Municipal Coronel Suárez
city: Buenos Aires
country: Argentina
facility: Hospital Universitario, Universidad Abierta Interamericana
city: Buenos Aires
country: Argentina
facility: Sanatorio Anchorena
city: Buenos Aires
country: Argentina
facility: Sanatorio de la Trinidad
city: Buenos Aires
country: Argentina
facility: Sanatorio de los Arcos
city: Buenos Aires
country: Argentina
facility: Sanatorio Dr. Julio Méndez
city: Buenos Aires
country: Argentina
facility: Sanatorio Mater Dei
city: Buenos Aires
country: Argentina
facility: Sanatorio Otamendi y Miroli
city: Comodoro Rivadavia
country: Argentina
facility: Hospital Regional de Comodoro Rivadavia
city: Córdoba
country: Argentina
facility: Hospital Tránsito Cáceres de Allende
city: Córdoba
country: Argentina
facility: Sanatorio Allende
city: General Roca
country: Argentina
facility: Hospital Zonal Francisco López Lima
city: Haedo
country: Argentina
facility: Hospital Interzonal General de Agudo Profesor Dr .Luis Guemes
city: La Plata
country: Argentina
facility: Hospital Interzonal de Agudos San Martin
city: Mar del Plata
country: Argentina
facility: Hospital Privado de Comunidad
city: Mendoza
country: Argentina
facility: Hospital Central
city: Mendoza
country: Argentina
facility: Hospital Lagomaggiore
city: Pilar
country: Argentina
facility: Hospital Universitario Austral
city: Rosario
country: Argentina
facility: Hospital Provincial del Centenario
city: Río Gallegos
country: Argentina
facility: Policlínico Atlántico del Sur
city: Río Grande
country: Argentina
facility: Hospital Regional Rio Grande
city: San Isidro
country: Argentina
facility: Sanatorio de la Trinidad
city: San Isidro
country: Argentina
facility: Sanatorio Las Lomas
city: San Luis
country: Argentina
facility: Hospital de San Luis
city: San Salvador de Jujuy
country: Argentina
facility: Hospital Pablo Soria
city: San Salvador de Jujuy
country: Argentina
facility: Sanatorio Nuestra Señora del Rosario
city: Temperley
country: Argentina
facility: Sanatorio Juncal
city: Vicente López
country: Argentina
facility: Clínica Olivos
city: Villa María
country: Argentina
facility: Clínica Privada de Especialidades de Villa María
city: Adelaide
country: Australia
facility: Calvary Wakefield Hospital
city: Adelaide
country: Australia
facility: Flinders Medical Center
city: Ballarat
country: Australia
facility: Ballarat Health Services
city: Bendigo
country: Australia
facility: Bendigo Hospital
city: Brisbane
country: Australia
facility: Mater Health Services
city: Canberra
country: Australia
facility: Canberra Hospital
city: Darwin
country: Australia
facility: Royal Darwin Hospital
city: Geelong
country: Australia
facility: Barwon Health, Geelong Hospital
city: Hobart
country: Australia
facility: Royal Hobart Hospital
city: Liverpool
country: Australia
facility: Liverpool Hospital
city: Melbourne
country: Australia
facility: Alfred Hospital
city: Melbourne
country: Australia
facility: Royal Melbourne Hospital
city: Melbourne
country: Australia
facility: St Vincent's Hospital
city: Melbourne
country: Australia
facility: The Northern Hospital
city: Melbourne
country: Australia
facility: The Western Hospital
city: Sale
country: Australia
facility: Central Gippsland Hospital
city: Sidney
country: Australia
facility: Concord Hospital
city: Sidney
country: Australia
facility: Nepean Hospital
city: Sidney
country: Australia
facility: St George Hospital
city: Sidney
country: Australia
facility: St Vincent's Hospital
city: La Paz
country: Bolivia
facility: Hospital Obrero No.1
city: La Paz
country: Bolivia
facility: Instituto Gastroenterológico
city: Belo Horizonte
country: Brazil
facility: Hospital da Baleia
city: Belo Horizonte
country: Brazil
facility: Hospital da Polícia Militar
city: Belo Horizonte
country: Brazil
facility: Hospital de Pronto Socorro Risoleta Tolentino Neves
city: Belo Horizonte
country: Brazil
facility: Hospital Dia e Maternidade Unimed-BH
city: Belo Horizonte
country: Brazil
facility: Hospital Felício Rocho
city: Belo Horizonte
country: Brazil
facility: Hospital Júlia Kubitschek
city: Belo Horizonte
country: Brazil
facility: Hospital Luxemburgo
city: Belo Horizonte
country: Brazil
facility: Hospital Madre Teresa
city: Belo Horizonte
country: Brazil
facility: Hospital Nossa Senhora Aparecida
city: Belo Horizonte
country: Brazil
facility: Hospital São Francisco-Setimig
city: Belo Horizonte
country: Brazil
facility: Hospital Universitario Sao Jose
city: Belo Horizonte
country: Brazil
facility: Hospital Vera Cruz
city: Belo Horizonte
country: Brazil
facility: Hospital Vila da Serra
city: Contagem
country: Brazil
facility: Hospital Santa Rita
city: Divinópolis
country: Brazil
facility: Hospital São João de Deus
city: Fortaleza
country: Brazil
facility: Hospital de Messejana
city: Fortaleza
country: Brazil
facility: Hospital Universitário Walter Cantídio
city: Juiz de Fora
country: Brazil
facility: Hospital Universitário da Universidade Federal de Juiz de Fora
city: Lavras
country: Brazil
facility: Hospital Vaz Monteiro
city: Ouro Preto
country: Brazil
facility: Santa Casa de Misericórdia de Ouro Preto
city: Ponte Nova
country: Brazil
facility: Hospital Arnaldo Gavazza Filho
city: Sete Lagoas
country: Brazil
facility: Hospital Nossa Senhora das Graças
city: Viçosa
country: Brazil
facility: Hospital São João Batista
city: Halifax
country: Canada
facility: Queen Elizabeth II Health Sciences Centre
state: Nova Scotia
city: Brampton
country: Canada
facility: William Osler Health Science Centre
state: Ontario
city: Hamilton
country: Canada
facility: Saint Joseph Hospital
state: Ontario
city: Ottawa
country: Canada
facility: Ottawa Hospital
state: Ontario
city: Toronto
country: Canada
facility: Mount Sinai Hospital
state: Ontario
city: Toronto
country: Canada
facility: Saint Michael´s Hospital
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Health Science Centre
state: Ontario
city: Toronto
country: Canada
facility: Toronto General Hospital
state: Ontario
city: Toronto
country: Canada
facility: Toronto Hospital Western Division
state: Ontario
city: Toronto
country: Canada
facility: Toronto Western Hospital
state: Ontario
city: Copiapo
country: Chile
facility: Hospital de Copiapo
city: Coquimbo
country: Chile
facility: Hospital de Coquimbo
city: Santiago
country: Chile
facility: Instituto Nacional del Tórax
city: Beijing
country: China
facility: Beijing Chaoyang Hospital
city: Beijing
country: China
facility: Beijing Hospital
city: Beijing
country: China
facility: Beijing Huaxin Hospital
city: Beijing
country: China
facility: Beijing TCM Hospital
city: Beijing
country: China
facility: Beijing Tongren Hospital
city: Beijing
country: China
facility: Peking Union Medical College Hospital
city: Beijing
country: China
facility: Peking University 3rd Hospital
city: Beijing
country: China
facility: PLA 304 Hospital
city: Beijing
country: China
facility: PLA General Hospital
city: Beijing
country: China
facility: PLA Navy General Hospital
city: Beijing
country: China
facility: Sino-Japanese Friendship Hospital
city: Changchun
country: China
facility: Jilin University 2nd Hospital
city: Chengdu
country: China
facility: Sichuan Provincial Hospital
city: Chengdu
country: China
facility: West China Hospital
city: Chongqing
country: China
facility: Chongqing Medical University 1st Hospital
city: Chongqing
country: China
facility: Daping Hospital
city: Chuxiong
country: China
facility: Yunnan Chuxiong People's Hospital
city: Dalian
country: China
facility: Dalian Medical University 1st Hospital
city: Guangdong
country: China
facility: Guangdong General Hospital
city: Guangzhou
country: China
facility: Sun Yet-Sen University 6th Hospital
city: Haikou
country: China
facility: Hainan Medical College Hospital
city: Haikou
country: China
facility: Hainan Provincial People's Hospital
city: Haining
country: China
facility: Zhejiang Haining People's Hospital
city: Hangzhou
country: China
facility: Zhejiang Tongde Hospital
city: Hong Kong
country: China
facility: North District Hospital
city: Hong Kong
country: China
facility: Pamela Youde Nethersole Eastern Hospital
city: Hong Kong
country: China
facility: Prince Margaret Hospital
city: Hong Kong
country: China
facility: Prince Of Wales Hospital
city: Hong Kong
country: China
facility: Queen Elizabeth Hospital
city: Kunming
country: China
facility: Kunming City 3rd People's Hospital
city: Kunming
country: China
facility: Kunming Medical College 1st Hospital
city: Nanchang
country: China
facility: Nanchang University 2nd Hospital
city: Nanjing
country: China
facility: Southeast University Zhongda Hospital
city: Nantong
country: China
facility: Nantong 1st People's Hospital
city: Shijiazhuang
country: China
facility: Hebei Medical University 4th Hospital
city: Suzhou
country: China
facility: Suzhou University 1st Hospital
city: Tangshan
country: China
facility: Fengrun District People's Hospital
city: Wuhan
country: China
facility: Wuhan University Zhongnan Hospital
city: Wuxi
country: China
facility: Wuxi Municipal People's Hospital
city: Xi'an
country: China
facility: Xi'an Jiaotong University 1st Hospital
city: Xuzhou
country: China
facility: Xuzhou Central Hospital
city: Yantai
country: China
facility: Yantai Yuhuangding Hospital
city: Barranquilla
country: Colombia
facility: Clínica General del Norte
city: Bogotá
country: Colombia
facility: Clínica Fundadores
city: Bogotá
country: Colombia
facility: Clínica Shaio
city: Bogotá
country: Colombia
facility: Grupo Cimca Hospital de San José (medical ICU)
city: Bogotá
country: Colombia
facility: Grupo Cimca Hospital de Suba
city: Bogotá
country: Colombia
facility: Grupo Cimca Hospital San José
city: Bogotá
country: Colombia
facility: Hospital Santa Clara
city: Bucaramanga
country: Colombia
facility: Fundación cardiovascular colombiana
city: Cali
country: Colombia
facility: Centro Medico Imbanaco
city: Cali
country: Colombia
facility: Clínica Fundación Valle Lili
city: Cartagena de Indias
country: Colombia
facility: Nuevo Hospital Bocagrande
city: Ibague
country: Colombia
facility: Hospital Federico Lleras Acosta
city: Itagui
country: Colombia
facility: Hospital San Rafael
city: Medellín
country: Colombia
facility: Clinica Universitaria Bolivariana
city: Medellín
country: Colombia
facility: Clínica Cardiovascular
city: Medellín
country: Colombia
facility: Clínica Las Américas
city: Medellín
country: Colombia
facility: Clínica Medellín & Universidad Pontificia Bolivariana
city: Medellín
country: Colombia
facility: Corbic
city: Medellín
country: Colombia
facility: Hospital General de Medellín
city: Holbaek
country: Denmark
facility: Holbak
city: Koge
country: Denmark
facility: Koge
city: Naestved
country: Denmark
facility: Naestved
city: Nykobing Falster
country: Denmark
facility: Nykobing Falster
city: Roskilde
country: Denmark
facility: Roskilde
city: Slagelse
country: Denmark
facility: Slagelse
city: Cuenca
country: Ecuador
facility: Hospital José Carrasco Arteaga
city: Guayaquil
country: Ecuador
facility: Hospital Luis Vernaza
city: Ibarra
country: Ecuador
facility: Hospital San Vicente de Paul
city: Quito
country: Ecuador
facility: Hospital Carlos Andrade Marín
city: Quito
country: Ecuador
facility: Hospital de la Policía
city: Quito
country: Ecuador
facility: Hospital de los Valles
city: Quito
country: Ecuador
facility: Hospital de SOLCA (ICU medical surgical & ICU medical)
city: Quito
country: Ecuador
facility: Hospital Enrique Garcés
city: Quito
country: Ecuador
facility: Hospital Eugenio Espejo
city: Quito
country: Ecuador
facility: Hospital General de las Fuerzas Armadas
city: Quito
country: Ecuador
facility: Hospital Metropolitano
city: Quito
country: Ecuador
facility: Hospital Pablo Arturo Suárez
city: Cairo
country: Egypt
facility: Cairo University Hospitals
city: Armentieres
country: France
facility: Hôpital d'Armentières
city: Châlons en Champagne
country: France
facility: Centre Hospitalier de Châlons en Champagne
city: Creteil
country: France
facility: CHU Henri Mondor
city: d'Angers
country: France
facility: CHU d'Angers
city: Grenoble
country: France
facility: CHU De Grenoble
city: Le Mans
country: France
facility: Centre Hospitalier Du Mans
city: Lyon
country: France
facility: Hôpital Édouard Herriot
city: Montauban
country: France
facility: Centre Hospitalier De Montauban
city: Roanne
country: France
facility: Centre Hospitalier De Roanne
city: Rouen
country: France
facility: CHU Charles Nicolle
city: Saint-Malo
country: France
facility: Centre Hospitalier De Saint-Malo
city: Aachen
country: Germany
facility: Katholische Stiftung Marienhospital Aachen
city: Aachen
country: Germany
facility: Universitaetsklinikum Aachen
city: Andernach
country: Germany
facility: St. Nikolaus-Stiftshospital GmbH
city: Bad Salzungen
country: Germany
facility: Klinikum Bad Salzungen GmbH
city: Bad Urach
country: Germany
facility: Ermstalklinik Bad Urach
city: Berlin-Kreuzberg
country: Germany
facility: Vivantes Krankenhaus am Urban
city: Berlin
country: Germany
facility: Charité Universitaetsklinikum (ICU medical-surgical & ICU other)
city: Berlin
country: Germany
facility: Lungenklinik Heckeshorn
city: Bonn
country: Germany
facility: Evangelisches Waldkrankenhaus Bad Godesberg gGmbH
city: Bonn
country: Germany
facility: Universitaetsklinikum Bonn (ICU medical-surgical & ICU surgical)
city: Cottbus
country: Germany
facility: Carl-Thiem-Klinikum Cottbus gGmbH
city: Darmstadt
country: Germany
facility: Evangelisches Krankenhaus Elisabethenstift gGmbH
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus
city: Freiburg
country: Germany
facility: Evangelisches Diakoniekrankenhaus
city: Gotinga
country: Germany
facility: Universitaetsklinikum der Georg-August-Universitaet
city: Halle
country: Germany
facility: Staedtisches Krankenhaus Martha-Maria Halle-Doelau gGmbH
city: Hamburg
country: Germany
facility: Allgemeines Krankenhaus Harburg
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
city: Lueneburg
country: Germany
facility: Staedtisches Klinikum Lueneburg
city: Magdeburg
country: Germany
facility: Universitaetsklinikum
city: Mühlhausen
country: Germany
facility: Hufeland Klinikum GmbH
city: Neubrandenburg
country: Germany
facility: Dietrich-Bonhoeffer Klinikum Neubrandenburg
city: Regensburg
country: Germany
facility: Klinikum der Universitaet Regensburg
city: Sindelfingen
country: Germany
facility: Ermstalklinik Staedtisches Krankenhaus Sindelfingen
city: Ulm
country: Germany
facility: Bundeswehrkrankenhaus Ulm
city: Wittenberg
country: Germany
facility: Universitaetsklinikum der Martin-Luther-Universitaet Halle-Wittenberg
city: Wolfenbuttel
country: Germany
facility: Staedtisches Klinikum Wolfenbuttel
city: Zeitz
country: Germany
facility: Georgius-Agricola-Klinikum Zeitz
city: Thessaloniki
country: Greece
facility: Agios Pavlos General Hospital
city: Thessaloniki
country: Greece
facility: Ahepa Hospital
city: Thessaloniki
country: Greece
facility: Gennimata Hospital
city: Thessaloniki
country: Greece
facility: Papageorgiou Hospital
city: Debrecen
country: Hungary
facility: Kenezy Hospital
city: Szeged
country: Hungary
facility: University of Szeged (Four ICU)
city: Bhubaneswar
country: India
facility: Kalinga Hospital
city: Calcutta
country: India
facility: Calcutta Medical Research Institute
city: Chennai
country: India
facility: Apollo Hospitals
city: Gurgaon
country: India
facility: Artemis Health Institute
city: Indore
country: India
facility: CHL Apollo Hospital
city: Jamshedpur
country: India
facility: Tata Main Hospital
city: Kolkata
country: India
facility: AMRI Hospitals Kolkata
city: Kolkata
country: India
facility: Calcutta medical research institute (CMRI)
city: Manipal City
country: India
facility: Kasturba Medical College
city: Mumbai
country: India
facility: Bombay Hospital Institute of Medical Sciences
city: Mumbai
country: India
facility: Hinduja Hospital
city: Mumbai
country: India
facility: Saifee Hospital
city: Mumbai
country: India
facility: Tata Memorial Hospital
city: Pune
country: India
facility: Ruby Hall Clinic
city: Surat
country: India
facility: CARE Hospitals
city: Vadodara
country: India
facility: Spandan Multispeciality Hospital
city: Bari
country: Italy
facility: Ospedale Policlinico, Università Di Bari
city: Bologna
country: Italy
facility: Policlinico Universitario "S. Orsola-Malpighi"
city: Firenze
country: Italy
facility: Ospedale "San Giovanni Di Dio"
city: Firenze
country: Italy
facility: Ospedale "Santa Maria Annunziata"
city: Milano
country: Italy
facility: Fondazione IRCCS "Cà Grande" Ospedale Maggiore Policlinico, Università Di Milano
city: Monza
country: Italy
facility: Ospedale "San Gerardo", Università Di Milano Bicocca
city: Napoli
country: Italy
facility: Ospedale "V. Monaldi"
city: Napoli
country: Italy
facility: Ospedale Policlinico "Federico II", Università Di Napoli
city: Novara
country: Italy
facility: Ospedale Maggiore Della Carità, Università Del Piemonte Orientale "Amedeo Avogadro"
city: Palermo
country: Italy
facility: Ospedale "Arnas Civico, Di Cristina, Benfratelli"
city: Palermo
country: Italy
facility: Policlinico "P. Giaccone", Università Di Palermo
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico "S. Matteo", Università Di Pavia (ICU 1 & ICU 2)
city: Roma
country: Italy
facility: Policlinico "Agostino Gemelli", Università Cattolica Del Sacro Cuore
city: Roma
country: Italy
facility: Policlinico "Umberto I", Università La Sapienza
city: Torino
country: Italy
facility: Ospedale "San Giovanni Battista - Molinette", Università Di Torino
city: Tokyo
country: Japan
facility: Tokyo Women's Medical University
city: Ansan
country: Korea, Republic of
facility: Hospital Korea University of Ansan
city: Anyang
country: Korea, Republic of
facility: Hallym University Medical Center
city: Cheongju
country: Korea, Republic of
facility: Hospital Chungbuk National University
city: Chuncheon
country: Korea, Republic of
facility: Hospital Chuncheon Sacred Heart Hospital, Hallym University Medical Center
city: Daegu
country: Korea, Republic of
facility: Hospital Catholic University of Daegu
city: Gyeongju
country: Korea, Republic of
facility: Hospital Dongguk University of Gyeongju
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center, University of Ulsan
city: Seoul
country: Korea, Republic of
facility: Hospital Ewha Womans University Mokdong
city: Seoul
country: Korea, Republic of
facility: Hospital Severance, Yonsei University Health System
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center, Sungkyunkwan University
city: Wonju
country: Korea, Republic of
facility: Hospital Yonsei University Wonju Christian
city: Yangsan
country: Korea, Republic of
facility: Hospital Pusan National University of Yangsan
city: Aguascalientes
country: Mexico
facility: Centenario Hospital Miguel Hidalgo
city: Ciudad Madero
country: Mexico
facility: Hospital Regional de Pemex
city: Mexico, DF
country: Mexico
facility: Hospital General de México
city: Mexico, DF
country: Mexico
facility: Instituto Nacional De Ciencias Médicas y Nutrición Salvador Zubirán
city: Miguel Hidalgo
country: Mexico
facility: Hospital Español de México
city: Mérida
country: Mexico
facility: Hospital Mérida Yucatán
city: México DF
country: Mexico
facility: Hospital Juárez de México
city: México DF
country: Mexico
facility: Hospital Regional 1° de Octubre, ISSSTE
city: México DF
country: Mexico
facility: Hospital Regional de Zona No.1 del IMSS
city: México DF
country: Mexico
facility: Hospital Ángeles de las Lomas
city: México DF
country: Mexico
facility: Instituto Nacional de Cancerología
city: México DF
country: Mexico
facility: Umae Hospital De Especialidades Dr. Antonio Fraga Mouret
city: México, DF
country: Mexico
facility: Centro Médico ABC
city: Nuevo León
country: Mexico
facility: Hospital Universitario de Nuevo León 'Dr. Eleuterio González'
city: Villahermosa
country: Mexico
facility: Hospital Regional de Alta Especialidad de la Mujer
city: Rabat
country: Morocco
facility: Hôpital des Specialites
city: Rabat
country: Morocco
facility: Hôpital Ibn Sina (Three units)
city: Rabat
country: Morocco
facility: Hôpital Militaire D'Instruction Mohamed V
city: Amsterdam
country: Netherlands
facility: Onze Lieve Vrouwe Gasthuis (OLVG)
city: Amsterdam
country: Netherlands
facility: Vrije Universiteit Medisch Centrum (VUMC) (Three units)
city: Den Haag
country: Netherlands
facility: Medisch Centrum Haaglanden
city: Haarlem
country: Netherlands
facility: Kennemer Gasthuis
city: Heerenveen
country: Netherlands
facility: Tjongerschans Ziekenhuis
city: Hoofddorp
country: Netherlands
facility: Spaarneziekenhuis
city: Leeuwarden
country: Netherlands
facility: Medical Center Leeuwarden (MCL)
city: Maastricht
country: Netherlands
facility: Universitair Medisch Centrum Maastricht
city: Auckland
country: New Zealand
facility: CVICU Auckland City Hospital
city: Auckland
country: New Zealand
facility: DCCM Auckland City Hospital
city: Auckland
country: New Zealand
facility: Middlemore
city: Christchurch
country: New Zealand
facility: Christchurch Hospital
city: Hamilton
country: New Zealand
facility: Waikato
city: Tauranga
country: New Zealand
facility: Tauranga Hospital
city: Wellington
country: New Zealand
facility: Wellington Hospital
city: Chiriquí
country: Panama
facility: Hospital Rafael Hernández
city: Lima
country: Peru
facility: Hospital Edgardo Rebagliatti Martins
city: Lima
country: Peru
facility: Hospital Guillermo Almenara Irigoyen
city: Poznan
country: Poland
facility: Karol Marcinkowski University Of Medical Sciences
city: Almada
country: Portugal
facility: Hospital Garcia de Orta
city: Amadora
country: Portugal
facility: Hospital da Luz
city: Cascais
country: Portugal
facility: Hospital de Cascais
city: Lisboa
country: Portugal
facility: Centro Hospitalar de Lisboa Central
city: Lisboa
country: Portugal
facility: Centro Hospitalar de Lisboa Norte
city: Lisboa
country: Portugal
facility: Hospital de Santo Antonio dos Capuchos, Centro Hospitalar de Lisboa Central, E.P.E.
city: Porto
country: Portugal
facility: Centro Hospitalar Do Porto - Hospital Geral De Santo António
city: Porto
country: Portugal
facility: Instituto Português de Oncología Francisco Gentil
city: Seide
country: Portugal
facility: Hospital De São Sebastião
city: Vila-Real
country: Portugal
facility: Centro Hospitalar Trás-Os-Montes E Alto Douro
city: San Juan
country: Puerto Rico
facility: VA Caribbean Health Care System
city: Arkhangelsk
country: Russian Federation
facility: City Hospital Number 1 of Arkhangelsk
city: Ekaterinburg
country: Russian Federation
facility: Hospital No.14
city: Moscow
country: Russian Federation
facility: Hospital No.7
city: Moscow
country: Russian Federation
facility: National Institute Of Surgery Named After A.V. Vishnevskij
city: Riyadh
country: Saudi Arabia
facility: King Saud Bin Abdulaziz University for Health Sciences
city: A Coruña
country: Spain
facility: Hospital Juan Canalejo
city: Albacete
country: Spain
facility: Hospital General de Albacete
city: Alcalá de Henares
country: Spain
facility: Hospital Príncipe de Asturias
city: Alcorcón
country: Spain
facility: Fundación Hospital Universitario de Alcorcón
city: Alicante
country: Spain
facility: Hospital General de Alicante
city: Alicante
country: Spain
facility: Hospital San Juan
city: Almeria
country: Spain
facility: Hospital Torrecárdenas
city: Aranjuez
country: Spain
facility: Hospital del Tajo
city: Arganda
country: Spain
facility: Hospital del Sureste
city: Avilés
country: Spain
facility: Hospital San Agustín
city: Badalona
country: Spain
facility: Hospital Germans Trias i Pujol
city: Baracaldo
country: Spain
facility: Hospital de Cruces
city: Barcelona
country: Spain
facility: Hospital Clinic-IDIBAPS (ICU medical & ICU respiratory)
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu y Sant Pau
city: Barcelona
country: Spain
facility: Hospital del Mar
city: Barcelona
country: Spain
facility: Hospital Sagrado Corazón
city: Barcelona
country: Spain
facility: Hospital SCIAS
city: Cartagena
country: Spain
facility: Hospital Santa María del Rosell
city: Castellón De La Plana
country: Spain
facility: Hospital de la Plana
city: Castellón De La Plana
country: Spain
facility: Hospital General de Castellón
city: Castellón De La Plana
country: Spain
facility: Hospital Provincial de Castellón
city: Ciudad Real
country: Spain
facility: Complejo Hospitalario de Ciudad Real
city: Coslada
country: Spain
facility: Hospital del Henares
city: Cáceres
country: Spain
facility: Hospital San Pedro de Alcántara
city: Córdoba
country: Spain
facility: Hospital Universitario Reina Sofia
city: Don Benito
country: Spain
facility: Hospital de Don Benito
city: El Ejido
country: Spain
facility: Hospital del Poniente
city: Elche
country: Spain
facility: Hospital General Universitario de Elche
city: Ferrol
country: Spain
facility: Hospital Arquitecto Marcide
city: Fuenlabrada
country: Spain
facility: Hospital de Fuenlabrada
city: Galdakao
country: Spain
facility: Hospital de Galdakao
city: Getafe
country: Spain
facility: Hospital Universitario de Getafe
city: Gijón
country: Spain
facility: Hospital de Cabueñes
city: Girona
country: Spain
facility: Hospital Universitario Doctor Josep Trueta
city: Granada
country: Spain
facility: Hospital Virgen de las Nieves
city: Guadalajara
country: Spain
facility: Hospital General de Guadalajara
city: Huelva
country: Spain
facility: Hospital Juan Ramón Jimenez
city: Jaen
country: Spain
facility: Complejo Hospitalario de Jaen
city: Jérez de la Frontera
country: Spain
facility: Hospital General de Jerez de la Frontera
city: La Palma
country: Spain
facility: Hospital General de La Palma
city: Las Palmas
country: Spain
facility: Hospital Doctor Negrín
city: Las Palmas
country: Spain
facility: Hospital Insular de Gran Canaria
city: León
country: Spain
facility: Complejo Hospitalario de León
city: Lleida
country: Spain
facility: Hospital Arnau de Vilanova
city: Logroño
country: Spain
facility: Hospital de San Pedro
city: Lugo
country: Spain
facility: Complejo Hospitalario Xeral-Calde
city: Madrid
country: Spain
facility: Fundación Jiménez Díaz
city: Madrid
country: Spain
facility: Hospital 12 de Octubre (Trauma ICU)
city: Madrid
country: Spain
facility: Hospital 12 de Octubre
city: Madrid
country: Spain
facility: Hospital Clínico San Carlos
city: Madrid
country: Spain
facility: Hospital de la Princesa
city: Madrid
country: Spain
facility: Hospital Gregorio Marañón
city: Madrid
country: Spain
facility: Hospital Infanta Leonor
city: Madrid
country: Spain
facility: Hospital Quirón
city: Madrid
country: Spain
facility: Hospital Universitario de la Paz
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro
city: Malaga
country: Spain
facility: Hospital Carlos Haya
city: Malaga
country: Spain
facility: Hospital Universitario Virgen de la Victoria
city: Mataró
country: Spain
facility: Hospital de Mataró
city: Murcia
country: Spain
facility: Hospital J .M. Morales Meseguer
city: Murcia
country: Spain
facility: Hospital Universitario Reina Sofia
city: Murcia
country: Spain
facility: Hospital Virgen de la Arrixaca
city: Móstoles
country: Spain
facility: Hospital de Móstoles
city: Orihuela
country: Spain
facility: Hospital Vega Baja de Orihuela
city: Ourense
country: Spain
facility: Complejo Hospitalario de Ourense
city: Oviedo
country: Spain
facility: Hospital Central de Asturias
city: Palencia
country: Spain
facility: Hospital Rio Carrión
city: Palma De Mallorca
country: Spain
facility: Hospital Son Llatzer
city: Palma De Mallorca
country: Spain
facility: Hospital Universitario Son Espasses
city: Pamplona
country: Spain
facility: Complejo Hospitalario de Navarra
city: Parla
country: Spain
facility: Hospital Infanta Cristina
city: Pontevedra
country: Spain
facility: Complejo Hospitalario Montecelo
city: Reus
country: Spain
facility: Hospital Universitario de San Juan
city: Sabadell
country: Spain
facility: Hospital Parc Taulí
city: Sagunto
country: Spain
facility: Hospital de Sagunto
city: Salamanca
country: Spain
facility: Complejo Hospitalario de Salamanca
city: Salamanca
country: Spain
facility: Hospital Clínico de Salamanca
city: San Sebastian
country: Spain
facility: Complejo Hospitalario de Donostia
city: Santiago de Compostela
country: Spain
facility: Complejo Hospitalario de Santiago de Compostela
city: Segovia
country: Spain
facility: Hospital General de Segovia
city: Sevilla
country: Spain
facility: Hospital Universitario de Valme
city: Sevilla
country: Spain
facility: Hospital Virgen del Rocío
city: Soria
country: Spain
facility: Hospital General de Soria
city: Terrassa
country: Spain
facility: Hospital Mutua de Terrassa
city: Teruel
country: Spain
facility: Hospital Obispo Polanco
city: Toledo
country: Spain
facility: Complejo Hospitalario de Toledo
city: Torrevieja
country: Spain
facility: Hospital de Torrevieja
city: Valdemoro
country: Spain
facility: Hospital Infanta Elena
city: Valencia
country: Spain
facility: Hospital Universitario de la Fe
city: Valencia
country: Spain
facility: Hospital Universitario Dr. Peset
city: Valladolid
country: Spain
facility: Hospital Clínico de Valladolid
city: Valladolid
country: Spain
facility: Hospital Rio Hortega
city: Vigo
country: Spain
facility: Hospital Meixoeiro
city: Vitoria
country: Spain
facility: Hospital Santiago Apóstol
city: Xativa
country: Spain
facility: Hospital Lluis Alcanyis
city: Zamora
country: Spain
facility: Hospital de Zamora
city: Zaragoza
country: Spain
facility: Hospital Clínico Lozano Blesa
city: Zaragoza
country: Spain
facility: Hospital Royo Vilanova
city: Tainan City
country: Taiwan
facility: Chi Mei Medical Center
city: Ariana
country: Tunisia
facility: Hospital Abderrahmane Mami
city: Mahdia
country: Tunisia
facility: Hospital Taher Sfar City
city: Monastir
country: Tunisia
facility: Hospital Fattouma Bourguina (ICU medical & ICU surgical)
city: Sfax
country: Tunisia
facility: CHU Habib Bourguiba
city: Sousse
country: Tunisia
facility: Hospital Universitarie Farhat Hached
city: Bursa
country: Turkey
facility: Uludag University Faculty of Medicine
city: Erciyes
country: Turkey
facility: Erciye Üniversity
city: Istanbul
country: Turkey
facility: Anadolu Medical Center Istanbul
city: Izmir
country: Turkey
facility: Atatürk Hospital
city: Kahramanmaras
country: Turkey
facility: Sutcu İmam University
city: Kirikkale
country: Turkey
facility: Kirikkale University
city: Mersin
country: Turkey
facility: Faculty of Medicine Mersin University
city: Van
country: Turkey
facility: Medical Faculty of Yuzuncu Yil University
city: Carmelo
country: Uruguay
facility: CAAMOC Carmelo
city: Colonia
country: Uruguay
facility: Orameco
city: Florida
country: Uruguay
facility: Hospital de Florida
city: Las Piedras
country: Uruguay
facility: CRAMI
city: Maldonado
country: Uruguay
facility: Hospital de Maldonado
city: Maldonado
country: Uruguay
facility: Sanatorio Mautone
city: Mercedes
country: Uruguay
facility: Sanatorio CAMS
city: Montevideo
country: Uruguay
facility: CASMU Nº2
city: Montevideo
country: Uruguay
facility: Circulo Católico
city: Montevideo
country: Uruguay
facility: CUDAM
city: Montevideo
country: Uruguay
facility: Hospital de Clínicas
city: Montevideo
country: Uruguay
facility: Hospital Español
city: Montevideo
country: Uruguay
facility: Hospital Evangélico
city: Montevideo
country: Uruguay
facility: Hospital Maciel
city: Montevideo
country: Uruguay
facility: Hospital Pasteur
city: Montevideo
country: Uruguay
facility: Hospital Policial
city: Montevideo
country: Uruguay
facility: Impassa
city: Montevideo
country: Uruguay
facility: Sanatorio Americano
city: Pando
country: Uruguay
facility: CAAMEPA
city: Paysandú
country: Uruguay
facility: COMEPA
city: Paysandú
country: Uruguay
facility: Hospital Escuela del Litoral
city: Punta del Este
country: Uruguay
facility: Sanatorio Cantegril
city: Anzoategui
country: Venezuela
facility: Hospital Centro de Especialidades
city: Caracas
country: Venezuela
facility: Hospital Clínico Universitario
city: Caracas
country: Venezuela
facility: Hospital de Clínicas
city: Caracas
country: Venezuela
facility: Hospital Miguel Pérez Carreño
city: Hanoi
country: Vietnam
facility: Viet Duc Hospital
Study officials:
affiliation: Hospital Universitario de Getafe, Spain
name: Andres Esteban, MD, PhD
role: STUDY_DIRECTOR
affiliation: Hospital Universitario de Getafe, Spain
name: Fernando Frutos-Vivar, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Toronto, Ontario, Canada
name: Niall D Ferguson, MD, MsC
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Texas Health Science Center, San Antonio, Texas, USA
name: Antonio Anzueto, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Clinica Medellin & Universidad Pontificia Bolivariana, Colombia
name: Marco González, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: AP-HP, Centre Hospitalier Albert Chenevier, Henri Mondor, Créteil, France
name: Arnaud W Thille, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hannover Medical School
name: Konstantinos Raymondos, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Agostino Gemelli University Hospital, Università Cattolica del Sacro Cuore, Rome, Italy
name: Salvatore Maggiore, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
name: Yaseen Arabi, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital de Santo António dos Capuchos, Lisboa, Portugal
name: Rui Moreno, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Fattouma Bourguiba, Monastir, Tunisia
name: Fekri Abroug, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital de Clínicas, Montevideo, Uruguay
name: Javier Hurtado, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital A.Posadas, Buenos Aires, Argentina
name: Fernando Rios, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital Nacional del Tórax, Santiago, Chile
name: Luis Soto, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital HIGA, Güemes, Argentina
name: Damian Violi, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Alfred Hospital, Melbourne, Australia
name: Jasmine Board, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Alfred Hospital, Melbourne, Australia
name: Andrew Davies, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital Obrero Número 1, La Paz, Bolivia
name: Fredi Sandi Lora, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital Universitário São José, Belo Horizonte, Brazil
name: Marco Antonio Soares Reis, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Peking Union Medical College Hospital, Beijing, Popular Republic of China
name: Bin Du, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Holbak, Denmark
name: Hans-Henrik Bülow, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital Militar de Quito, Ecuador
name: Manuel Jibaja, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Papageorgiou Hospital, Thessaloniki, Greece
name: Dimitros Matamis, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Asan Medical Center, University of Ulsan, Seoul, Korea
name: Younsuck Koh, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital Regional 1° de Octubre, ISSSTE, México DF, Mexico
name: Asisclo Villagómez, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hôpital Ibn Sina, Rabat, Morocco
name: Amine Ali Zeggwagh, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Medical Center Leeuwarden (MCL), Leeuwarden, The Netherlands
name: Michael Kuiper, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital No.1, Moscow, Russian Federation
name: Edward Nicolayenko, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital Universitario de Getafe, Spain
name: Nicolas Nin, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Istanbul Medical Faculty, Istanbul, Turkey
name: Nahit Cakar, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital de Clinicas de Caracas, Venezuela
name: Gabriel D'Empaire, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Esteban A, Anzueto A, Frutos F, Alia I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguia C, Nightingale P, Arroliga AC, Tobin MJ; Mechanical Ventilation International Study Group. Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA. 2002 Jan 16;287(3):345-55. doi: 10.1001/jama.287.3.345.
citation: Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, Gonzalez M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D'Empaire G, Sandi F, Matamis D, Montanez AM, Anzueto A; VENTILA Group. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med. 2008 Jan 15;177(2):170-7. doi: 10.1164/rccm.200706-893OC. Epub 2007 Oct 25.
citation: Nin N, Muriel A, Penuelas O, Brochard L, Lorente JA, Ferguson ND, Raymondos K, Rios F, Violi DA, Thille AW, Gonzalez M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Soto L, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bulow HH, Zeggwagh AA, Anzueto A, Sznajder JI, Esteban A; VENTILA Group. Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome. Intensive Care Med. 2017 Feb;43(2):200-208. doi: 10.1007/s00134-016-4611-1. Epub 2017 Jan 20.
citation: Esteban A, Frutos-Vivar F, Muriel A, Ferguson ND, Penuelas O, Abraira V, Raymondos K, Rios F, Nin N, Apezteguia C, Violi DA, Thille AW, Brochard L, Gonzalez M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Pelosi P, Soto L, Tomicic V, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bulow HH, Zeggwagh AA, Anzueto A. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med. 2013 Jul 15;188(2):220-30. doi: 10.1164/rccm.201212-2169OC.