Clinical trial NCT01302210: Detection, Education, Research and Decolonization Without Isolation in Long-term Care Facilities
Official title: Detection, Education, Research and Decolonization Without Isolation in Long-term Care to Control(DERAIL)MRSA
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Methicillin Resistant Staphylococcus Aureus
Keywords: MRSA
Cluster Randomized Trial
Infection Control Intervention
Lead sponsor: Endeavor Health
Sponsor class: OTHER
Collaborators: name: Agency for Healthcare Research and Quality (AHRQ)
First posted: 2011-02-24
Enrollment: 22302
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: Our hypothesis for the DERAIL MRSA program is that one can safely remove the colonization risk from nearly all residents (patients) in a way that does not interfere with the desired life-style for persons in these facilities and thereby reduce the risk of infection and lower the cost of care by avoiding preventable disease.

Detailed description: The primary endpoint will be measuring the reduction in MRSA colonization prevalence (percentage rate) in the intervention arm as compared to the control arm. One secondary endpoint is to compare the rate of MRSA disease (number of infections per 1,000 patients and 10,000 patient days) in the intervention and control arms. The other secondary endpoint is to determine the cost of MRSA screening and decolonization and compare it to the cost of MRSA disease treatment (both medication cost and the expense of any needed hospitalization for therapy of MRSA infection therapy) in the control arm. Achieving our primary goal of MRSA control will also demonstrate two secondary goals wthe investigators aim to achieve: one being that a scientific, planned approach to the issue of specific healthcare-associated infection in LTCFs can resolve these problems and the other that a partnership between acute and long-term care (e.g., ongoing relationship spanning at least 5 years) is beneficial in dealing with patient safety and quality practices across the United Sates Healthcare continuum.

Eligibility criteria: Inclusion Criteria:

* All patients in 18 LTCF nursing units randomly selected as intervention or control units

Exclusion Criteria:

* Patients that choose not to be included in the program

Primary outcomes:
measure: To record the effectiveness of an admission testing and immediate decolonization of positive persons protocol for reducing MRSA colonization prevalence in long term care facilities (LTCF's)
timeFrame: 12 months and 24 months
Secondary outcomes:
measure: To further develop an Infection Control Outreach Program designed to provide expert guidance on infectious disease prevention specific to LTCF's
timeFrame: 2 years
Other outcomes:
Locations:
city: Evanston
country: United States
facility: NorthShore University HealthSystem Research Institute
state: Illinois
Study officials:
affiliation: Endeavor Health
name: Lance R Peterson, MD
role: PRINCIPAL_INVESTIGATOR
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