Clinical trial NCT06658392: Domain-general and Domain-specific Contributions to the Development of Numerical Cognition
Official title: Domain-general and Domain-specific Contributions to the Development of Numerical Cognition
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: No Condition
Keywords: cognitive neuroscience
numerical cognition
Lead sponsor: Centre Hospitalier St Anne
Sponsor class: OTHER
First posted: 2024-10-26
Enrollment: 58
Sex: ALL
Minimum age (years): 5
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Exploring the non-symbolic and symbolic arithmetic competencies in two groups of children (5-, and 7-year-olds). Additionally, we explored the relationship with domain-general factors such as inhibition and attention. Recorded fMRI.

Detailed description: Using T2\*-weighted eip imaging, we measured BOLD response in two cohorts of healthy children while they were doing different cognitive tasks in the scanner. These tasks included solving non-symbolic (i.e. sets of elements) and symbolic (i.e. Arabic digits) addition and subtraction problems, a color control task, an attentional task measuring different facets of spatial attention, and a task measuring inhibition. We also recorded a high-resolution anatomical scan of the brain.

Eligibility criteria: Inclusion Criteria:

* school enrollment
* French as mother tongue
* right-handed
* normal medical, neurological and neuroradiological examinations - parents affiliated to a social security scheme

Exclusion Criteria:

* not within age range
* monocygotic twins
* - contraindications to an MRI examination (neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic ocular or cerebral foreign bodies close to nerve structures, metal prostheses, patient agitation: uncooperative or agitated patients, claustrophobic subjects, ventriculoperitoneal neurosurgical shunt valves, dental apparatus, etc.).
* sudden onset of cognitive problems that could indicate a stroke; a history of head trauma with loss of consciousness lasting more than 1 hour, or encephalitis; - a chronic neurological, psychiatric, endocrine, hepatic or infectious condition
* a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrinological or immunological disorders, cancer); - medication likely to interfere with brain imaging measurements
* color blindness or uncorrected visual disorders
* inability to take part in the study for geographical or psychiatric reasons
* presence of pervasive developmental and/or acquisition disorders identified by parents or legal guardians and/or teachers
* cerebral palsy
* impaired fine motor skills
* parents or legal guardians not affiliated to a social security scheme
* unaccompanied by parent(s) or legal guardian(s) during visits.
* tattoo not compatible with MRI
* children and parents under legal protection

Primary outcomes:
measure: BOLD response
timeFrame: BOLD response recorded during fMRI session
measure: BOLD response
timeFrame: during fMRI session
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Centre Hospitalier Sainte-Anne
Study officials:
affiliation: Promotor
name: Catherine OPPENHEIM, Pr
role: PRINCIPAL_INVESTIGATOR
References: