Clinical trial NCT05745272: Cardiovascular Risk Categories and Attaining LDL-C Targets in Middle Eastern Adults Aged 30-55 Years of Age
Official title: Cardiovascular Risk Categories and Attaining LDL-C Targets in Middle Eastern Adults Aged 30-55 Years of Age
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Atherosclerotic Cardiovascular Risk
Low-density-lipoprotein (LDL) Cholesterol
Keywords: Low-density lipoprotein cholesterol (LDL-C)
LDL-C targets
ASCVD risk levels
Middle East population
Lead sponsor: Jordan Collaborating Cardiology Group
Sponsor class: OTHER
Collaborators: name: The Cardiovascular Academy Group of the JCS
name: The Jordan Cardiac Society (JCS)
name: Istishari Hospital Department of Clinical Research
First posted: 2023-02-27
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Ambulatory care patients and in-hospital patients with any medical illness of coming for routine check ups.Age 18-55 both sexes.

Brief summary: Individuals evaluated for primary and secondary cardiovascular prevention have different levels of cardiovascular risk These levels of risk are the main determinants of the low-density lipoprotein cholesterol (LDL-C) target blood levels that need to be attained.

Detailed description: Individuals evaluated for primary and secondary cardiovascular prevention fall into different levels of cardiovascular risk according to their clinical profile of having atherosclerotic cardiovascular disease (ASCVD), risk factors, and their SCORE. These levels of risk are the main determinants of the low-density lipoprotein cholesterol (LDL-C) target blood levels that need to be attained using LDL-C-lowering agents (LLA).

Contemporary studies that evaluated levels of cardiovascular risk and LDL-C goal attainment in the Middle East are scarce. A prior study (CEPHEUS LEVANT) in the Middle East demonstrated that about 1 in 4 high-risk patients reach LDL-C goals.

The current study aims at studying cardiovascular risk categories according to the 2019 ESC/EAS and 2018 ACC/AHA Guidelines, and the attainment of LDL-C treatment goals in consecutive individuals aged 18-55 years who are evaluated in tertiary care centers as inpatients or in ambulatory care settings. The above age bracket was chosen because these are the individuals most prone to acute cardiovascular events with a high prevalence of diabetes mellitus and cigarette smoking.

Eligibility criteria: Inclusion Criteria:

* Age 18-55 y
* Individuals can give a history of the presence or absence of ASCVD and its risk factors

Exclusion Criteria:

* Age below 18 or older than 55
* Refusal of inability to give history on ASCVD and its risk factors

Primary outcomes:
measure: Risk level of ASCVD
timeFrame: 12 MONTHS
Secondary outcomes:
measure: LDL-cholesterol blood level
timeFrame: 12 months
Other outcomes:
Locations:
city: Amman
country: Jordan
facility: Istishari Hospital
Study officials:
affiliation: Department of Cardiology, Jordan Hospital, Amman, Jordan
name: Imad A. Alhaddad, MD FACC
role: STUDY_CHAIR
affiliation: Cardiology Department, Abdali Hospital
name: Ramzi Tabbalat
role: STUDY_DIRECTOR
affiliation: Department of Clinical Research, Istishari Hospital, Aman, Jordan
name: Ayman Hammoudeh, MD FACC
role: PRINCIPAL_INVESTIGATOR
References: