Clinical trial NCT04183920: To Determine the Activity and Mechanisms of Cranberries to Attenuate Skin Photoaging and Improve Skin Health in Women
Official title: To Determine the Activity and Mechanisms of Cranberries to Attenuate Skin Photoaging and Improve Skin Health in Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Skin Health
Lead sponsor: University of Florida
Sponsor class: OTHER
Collaborators: name: Ocean Spray, Inc.
First posted: 2019-12-03
Enrollment: 22
Sex: FEMALE
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: Previous studies have shown that cranberry phytochemicals scavenge reactive carbonyls. Cranberry polyphenols have been reported to attenuate collagen degradation and inhibit oxidative stress in human cells. We hypothesize that cranberry juice consumption will attenuate skin photoaging and improve skin health in women via alleviate oxidative stress.

Detailed description: One of the causative factors of skin ageing is cumulative oxidative damages due to aerobic metabolism and UV irradiation. Cumulation of reactive oxygen species (ROS) causes collagen glycation and crosslinking which are direct causes of skin ageing. Previous studies have shown that cranberry phytochemicals scavenge reactive carbonyls. Cranberry polyphenols have been reported to attenuate collagen degradation and inhibit oxidative stress in human cells. It is unknown whether cranberry juice consumption could protect against UV -induced erythema and improve overall skin health. Furthermore, if it does have effect, what will be the mechanism? This human intervention study will be conducted to answer these questions. We hypothesize that cranberry juice consumption will attenuate skin photoaging and improve skin health in women via alleviate oxidative stress.

Eligibility criteria: Inclusion Criteria:

* Healthy
* BMI (18.5-29.9)
* Body weight ≥110 pounds

Exclusion Criteria:

* Skin Cancer
* Smokers and frequent alcohol use
* Pregnancy
* Breast-feeding
* intake of medication that might influence the outcome of the study
* sunbathing or the use of tanning bed
* intake of vitamin/mineral supplements

Primary outcomes:
measure: Change from baseline Skin color change after UV irradiation at 28 days
timeFrame: Baseline, 28 days
measure: Change from baseline Skin transepidermal water loss
timeFrame: Baseline, 28 days
measure: Change from baseline SELS parameters
timeFrame: Baseline, 28 days
measure: Change in skin microbiome
timeFrame: Baseline, 28 days
measure: Change in baseline skin pH
timeFrame: Baseline, 28 days
measure: Change from baseline hydration
timeFrame: Baseline, 28 days
measure: Change in Skin erythema and melanin index
timeFrame: Baseline, 28 days
measure: Change in skin lipidome
timeFrame: baseline, 28 days
Secondary outcomes:
measure: Survival rate of human keratinocyte under UV light
timeFrame: 24 hours
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: Food Science and human nutrition department at University of Florida
state: Florida
Study officials:
affiliation: University of Florida
name: Liwei Gu, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ramasamy R, Yan SF, Schmidt AM. Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ann N Y Acad Sci. 2011 Dec;1243:88-102. doi: 10.1111/j.1749-6632.2011.06320.x.
citation: Liu H, Liu H, Wang W, Khoo C, Taylor J, Gu L. Cranberry phytochemicals inhibit glycation of human hemoglobin and serum albumin by scavenging reactive carbonyls. Food Funct. 2011 Aug;2(8):475-82. doi: 10.1039/c1fo10087d. Epub 2011 Aug 8.
citation: Heinrich U, Moore CE, De Spirt S, Tronnier H, Stahl W. Green tea polyphenols provide photoprotection, increase microcirculation, and modulate skin properties of women. J Nutr. 2011 Jun;141(6):1202-8. doi: 10.3945/jn.110.136465. Epub 2011 Apr 27.
citation: Heinrich U, Neukam K, Tronnier H, Sies H, Stahl W. Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women. J Nutr. 2006 Jun;136(6):1565-9. doi: 10.1093/jn/136.6.1565.