Clinical trial NCT02219295: SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition
Official title: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Disorder of Glucose Regulation
Keywords: SGLT1 (sodium dependent glucose transporter)
Glut-transporters
taste receptors genes
sweet taste receptor T1R2T1R3
bitter taste receptors of the hTAS2gene family
Lead sponsor: German Institute of Human Nutrition
Sponsor class: OTHER
Collaborators: name: Technical University of Munich
First posted: 2014-08-18
Enrollment: 97
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: BASIC_SCIENCE

Brief summary: We investigate the impact of taste receptors (sweet, bitter and umami) on human metabolism. There ist growing evidence, that components of the taste signalling system, including the taste receptor proteins , have important functions in the regulation of metabolic parameters in non-gustatory tissues.

Detailed description: We apply different sweet, bitter and umami taste compounds in a single dose in the human intervention. We use substances as for instance glucose, sucrose,saccharin and lactisol in the sweet part, and substances from cabbage, beer or red endive in the bitter part. For umami we take glutamate.

Blood samples are collected at baseline and 6 times thereafter up to 3hours, to analyse the incretins GLP-1(glucagon-like peptide 1) and GIP(gastrointestinal polypeptide) and other peptide hormones as insulin and PYY(peptide tyrosin trosin) in human beings.

Gastrointestinal mucosa is taken by gastroscopy from the lower duodenum from study subjects for analysis for the presence or absence of functional taste receptors in gastrointestinal tissues.

Eligibility criteria: Inclusion Criteria:

* Healthy persons

Exclusion Criteria:

* Tumor in history
* Pregnancy
* Severe illness in history
* Bodymass index below 18

Primary outcomes:
measure: Area under the curve (AUC): changes of expression levels of the sweet , bitter und umami taste receptors in humans in the upper bowel and responses of incretins to receptor agonists and antagonists
timeFrame: three years
Secondary outcomes:
measure: changes in the signalling cascade of the sweet receptor SGLT1 (sodium tranporter 1), changes of receptor expression
timeFrame: 3 years
Other outcomes:
measure: Changes in the Area under the Curve (AUC) for PYY in different bitter tasting substances
timeFrame: 3 years
Locations:
city: Bergholz-Rehbrücke
country: Germany
facility: Department of Clinical Nutrition
state: Brandenburg
Study officials:
affiliation: German Institute of Human Nutrition
name: Andreas FH Peiffer, Prof
role: PRINCIPAL_INVESTIGATOR
References:
citation: Keyhani-Nejad F, Kemper M, Schueler R, Pivovarova O, Rudovich N, Pfeiffer AF. Effects of Palatinose and Sucrose Intake on Glucose Metabolism and Incretin Secretion in Subjects With Type 2 Diabetes. Diabetes Care. 2016 Mar;39(3):e38-9. doi: 10.2337/dc15-1891. Epub 2015 Dec 30. No abstract available.