Clinical trial NCT02165592: Assessment of Proprioceptive and Functional Characteristics in Patients With Hemophilia
Official title: Assessment and Identification of Proprioceptive and Functional Changes in Patients With Hemophilia of the Region of Murcia.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hemophilia
Keywords: Hemophilia
Arthropathy
Range of Motion
Strength
Proprioception
Gait
Quality of Life
Lead sponsor: Universidad Católica San Antonio de Murcia
Sponsor class: OTHER
First posted: 2014-06-17
Enrollment: 60
Sex: MALE
Minimum age (years): 6
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients from the Murcia Regional Hemophilia Association

Brief summary: Analyze and evaluate the skeletal muscle of patients affected with hemophilia in the Region of Murcia.

* Describe the periarticular muscular deficit of the lower limbs, depending on the degree of injury: acute and chronic, or subacute.
* Identify the range of motion of joints with higher prevalence of hemophilic arthropathy.
* Detect the biomechanical changes of the lower limbs and their impact on gait in patients with hemophilia.
* Assess the factors that influence the perception of illness and quality of life of patients with hemophilia.

Detailed description: Descriptive study of joint involvement in hemophilia patients with and without a history of hemarthrosis in lower limbs.

Descriptive study of alterations in the strength of the periarticular muscles of lower limbs as a result of acute conditions or the development of chronic articular sequelae.

Descriptive study of the biomechanical alterations in weight-bearing joints of lower limbs and their impact on gait in patients with hemophilia.

Descriptive study of the relationship between skeletal muscle pathology in patients with hemophilia and their perceptions of it and their quality of life.

Eligibility criteria: Inclusion Criteria:

* Patients with hemophilia A and B
* Patients of all ages (from 6 to 70 years).
* With or without joint damage clinically diagnosed, and with or without a previous history of hemarthrosis joint load legs.
* Residents in the Autonomous Community of the Region of Murcia.

Exclusion Criteria:

* Patients without ambulation
* Patients diagnosed with other congenital coagulopathy (von Willebrand disease, etc..).
* Patients with neurological or cognitive impairments that prevent understanding the questionnaires and physical tests.

Primary outcomes:
measure: Assess the range of motion
timeFrame: Screening visit
measure: Assess the muscular strength
timeFrame: Screening visit
measure: Assess the joint pain
timeFrame: Screening visit
measure: Assess the variables of strength
timeFrame: Screening visit
measure: Assess the peak force
timeFrame: Screening visit
measure: Assess the contractile activity
timeFrame: Screening visit
measure: Assess the state joint
timeFrame: Screening visit
measure: Assess the list of activities
timeFrame: Screening visit
measure: Assess the physical performance
timeFrame: Screening visit
measure: Assess the health Profile
timeFrame: Screening visit
measure: Assess the quality of life
timeFrame: Screening visit
Secondary outcomes:
measure: Age, sex, weight of the patients with hemophilia
timeFrame: Screening visit
measure: Diagnosis, severity of hemophilia, type of treatment (prophylactic or on-demand) and inhibitors
timeFrame: Screening visit
measure: Frequency of joint bleeds in the previous month and bleeding during the assessment
timeFrame: Screening visit
Other outcomes:
Locations:
city: Murcia
country: Spain
facility: Universidad Católica San Antonio, Murcia
Study officials:
References: