Clinical trial NCT04098094: Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
Official title: Prevalence of Right Ventricular Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases and Its Impact on Outcomes
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Exacerbation of COPD
Acute Exacerbation of Bronchiectasis
Acute Exacerbation of Asthma
Interstitial Lung Disease
Neuromuscular Diseases
Obesity Hypoventilation Syndrome
Acute Respiratory Failure
Lead sponsor: Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Sponsor class: OTHER
First posted: 2019-09-23
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure.

Brief summary: Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure. The main objective is to determine the prevalence of right ventricular (RV) dysfunction in this population and to analyze the impact of such a complication on outcomes (survival at day-28, duration of non-invasive or mechanical ventilation, duration of hospital stay). RV function will be assessed by echocardiography at admission, after 3 days and at discharge. Plasma NT-proBNP and troponin levels will be collected.

Detailed description: Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure.

Inclusion Criteria:

* Chronic respiratory disease (COPD, ILD, OHS...)
* Admission in ICU for acute respiratory failure
* Patient's non-opposition

Exclusion Criteria:

* Patients \< 18 year-old
* Protected patients
* Pregnant women The main objective is to determine the prevalence of right ventricular (RV) dysfunction in this population and to analyze the impact of such a complication on outcomes (survival at day-28, duration of non-invasive or mechanical ventilation, duration of hospital stay). RV function will be assessed by echocardiography at admission, after 3 days and at discharge. Plasma NT-proBNP and troponin levels will be collected.

Eligibility criteria: Inclusion Criteria:

* Chronic respiratory disease (COPD, ILD, OHS...)
* Admission in ICU for acute respiratory failure
* Patient's non-opposition

Exclusion Criteria:

* Patients \< 18 year-old
* Protected patients
* Pregnant women

Primary outcomes:
measure: Survival
timeFrame: Day 28
Secondary outcomes:
measure: Duration of ventilation
timeFrame: Day 28
Other outcomes:
measure: Duration of hospital stay
timeFrame: Day 28
Locations:
city: Paris
country: France
facility: Service de Pneumologie et Réanimation Médicale, Groupe Hospitalier Pitié Salpêtrière Paris, France
Study officials:
affiliation: Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
name: Alexandre Demoule, MD, PHD
role: PRINCIPAL_INVESTIGATOR
References: