louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02512614: Evaluation of Novel Antimicrobial Hand Towels
Official title: Evaluation of Novel Antimicrobial Hand Towels
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Diarrheal Diseases
Acute Respiratory Infections
Fever
Skin Infection
Lead sponsor: Centers for Disease Control and Prevention
Sponsor class: FED
First posted: 2015-07-31
Enrollment: 449
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: In March 2012, the investigators initiated a prospective, cluster-randomized, controlled field trial in Kisumu County, located in an area in western Kenya which has the highest under-five mortality rate in Kenya with 149 childhood deaths per 1,000 live births 9. The study was designed to evaluate the effectiveness of an antimicrobial hand towel (hereafter referred to as towel) in preventing diarrheal diseases, acute respiratory infections, self-reported fever, and skin infections in children \<2 years old.

Detailed description: In March 2012, the investigators initiated a prospective, cluster-randomized, controlled field trial in Kisumu County, located in an area in western Kenya which has the highest under-five mortality rate in Kenya with 149 childhood deaths per 1,000 live births 9. The study was designed to evaluate the effectiveness of an antimicrobial hand towel (hereafter referred to as towel) in preventing diarrheal diseases, acute respiratory infections (ARIs), self-reported fever, and skin infections in children \<2 years old.

Eligibility criteria: Inclusion Criteria:

* Mother of a child \<2 years old

Exclusion Criteria:

* Inaccessible enumeration area in the rainy season
* Multiple eligible children in a single compound
* Moved between census and round 1

Primary outcomes:
measure: Number of participants with diarrheal disease
timeFrame: Within 48 hours of enrollment
Secondary outcomes:
measure: Number of participants with respiratory infections
timeFrame: Within 48 hours of enrollment
measure: Number of participants with a subjective fever
timeFrame: Within 48 hours of enrollment
measure: Number of participants with a skin infection
timeFrame: Within 48 hours of enrollment
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01082614: Arterial Pulse Waveform Contour Analysis for Intraoperative Goal Directed Therapy in Major Abdominal Surgery
Official title: Evaluation of the Use of Arterial Pulse Waveform Contour Analysis for Early Goal Directed Therapy in Patients Undergoing Major Abdominal Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Surgical Procedures, Operative
Lead sponsor: Loma Linda University
Sponsor class: OTHER
First posted: 2010-03-08
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluates whether using information from a special arterial blood pressure monitor to guide how much fluid is given during surgery changes how long a patient stays in the hospital after the surgery. There is scientific evidence from using similar information from different devices that this technique might allow us to do a better job giving fluids during surgery and that this may be associated with shorter hospital stay after surgery.


Eligibility criteria: Inclusion Criteria:

* All patients requiring elective or semi-elective major abdominal surgery will be assessed for eligibility.

Exclusion Criteria:

* Age under 18 years old,
* Coagulopathy,
* Significant renal/hepatic dysfunction (creatine \>50% or liver enzymes \> 50% of normal values),
* Congestive heart failure,
* Cardiac arrhythmias producing irregular rhythms, and
* Patient choice.

Primary outcomes:
measure: Length of Postoperative Hospital Stay
timeFrame: within one month
Secondary outcomes:
measure: Quality of Recovery Score on Postoperative Day 2
timeFrame: Postoperative day 2
measure: Quality of Recovery Score on Postoperative Day 4
timeFrame: Postoperative day 4
Other outcomes:
Locations:
city: Loma Linda
country: United States
facility: Loma Linda University
state: California
Study officials:
affiliation: Loma Linda University
name: Richard L. Applegate II, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03098914: Clinical Characteristics and Microbiology of Community-Acquired Pneumonia
Official title: Clinical Characteristics and Microbiology of Community-Acquired Pneumonia: A Prospective Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Community-acquired Pneumonia
Keywords: Pathogen
Mortality
Community-acquired Pneumonia
Risk factors
Lead sponsor: Beijing Haidian Hospital
Sponsor class: OTHER
Collaborators: name: Beijing Tsinghua Chang Gung Hospital
name: Chinese PLA General Hospital
First posted: 2017-04-04
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with commnuity acquired pneumonia

Brief summary: Community-Acquired Pneumonia has become common. Additionally, the mortality is high. But the epidemiology of pathogen is various in different areas, which is crucial for the key treatment. In addition, the risk factors of patients who died in 3 or 7 days in china is not clear, comparing with patients who died in 14 or 28 days or who survived.


Eligibility criteria: Inclusion Criteria:

* Confirmed community acquired pneumonia
* Age≥18 ys

Exclusion Criteria:

* HIV infection

Primary outcomes:
measure: the epidemiology of pathogen of community-acquired pneumonia in the three hospitals
timeFrame: confirmed as community-acquired pneumonia （2 weeks）
Secondary outcomes:
measure: risk factors of patients who died in 3 or 7 days
timeFrame: in one week（3 days or 7days）
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Haidian Hospital
state: Beijing
Study officials:
References:
Clinical trial NCT05253014: Different Approaches for the Management of Post-dural Puncture Headache
Official title: Comparative Study Between Different Approaches for the Management of Post-dural Puncture Headache
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post-Dural Puncture Headache
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2022-02-23
Enrollment: 120
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Detecting the efficacy and safety of trans-nasal sphenopalatine ganglion block using either lidocaine 2% or bupivacaine 0.5 % as a treatment line for post-dural puncture headache


Eligibility criteria: Inclusion Criteria:

* The ASA physical condition І-П
* the patient underwent CS under spinal anesthesia
* The headache developed within 5 days after the dural puncture
* There is no different explanation for the headache

Exclusion Criteria:

* coagulopathy
* history of nasal bleeding
* nasal polyp
* septal deviation
* local anesthetics reaction

Primary outcomes:
measure: postdural puncture headache
timeFrame: within five days after the dural puncture
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Sohag faculty of medicine
Study officials:
References:
Clinical trial NCT01953614: Effects of Chiropractic Adjustments on Brain Function Using Quantitative Encephalography
Official title: Effects of Chiropractic Adjustments on Brain Function Using Quantitative Encephalography
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Brain Function
Keywords: quantitative encephalography
brain computer interface
chiropractic
sacro-occipital technique
Lead sponsor: Life University
Sponsor class: OTHER
First posted: 2013-10-01
Enrollment: 30
Sex: ALL
Minimum age (years): 10
Maximum age (years): 99
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Despite the abundance of theories concerning the effects of chiropractic adjustments on brain function, this remains an understudies area for the profession.

Quantitative Electroencephalography (qEEG)is a technique that allows for an in-depth analysis of brain function. A normative database will be used to compare before, during and after effects of chiropractic adjustments on brain function. This will include usage of Low Resolution Electromagnetic Tomography (LORETA).

This study seeks to objectively document effects of chiropractic adjustments on brain function.


Eligibility criteria: Inclusion Criteria:

* Must be able to receive chiropractic adjustments

Exclusion Criteria:

* No benzodiazepine class drugs in study participants
* No use of medicines such as Sudafed (pseudoephedrine) or Nyquil (Doxylamine succinate)
* At least 30 days since last chiropractic adjustment

Primary outcomes:
measure: Changes in quantitative EEG values as compared to a normative database
timeFrame: Baseline, during adjustment, after adjustment, follow up in 7 days
Secondary outcomes:
measure: Behavioral assessment questionaire
timeFrame: At baseline, one week after adjustment.
Other outcomes:
Locations:
city: Marietta
country: United States
facility: Life University
state: Georgia
Study officials:
References:
Clinical trial NCT03743714: Effects of Yoga Training on Postural Stability
Official title: Effects of Yoga Training on Postural Stability and Investigating the Gender-Related Responses
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Gender
Postural; Defect
Physical Activity
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2018-11-16
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Postural stability can be affected by multiple factors. Such as; body mass, inactivity, age and etc. This study was planned with the aim of investigating the effects of Yoga training on postural stability of males and females. Yoga is a treatment model for body flexibility, body awareness, and strength.

Detailed description: Postural stability can be affected by multiple factors. Such as; body mass, inactivity, age and etc. This study was planned with the aim of investigating the effects of Yoga training on postural stability of males and females. Yoga is a treatment model for body flexibility, body awareness, and strength.

Eligibility criteria: Inclusion Criteria:

* Sedentary males and females
* want to participate

Exclusion Criteria:

* have any disorders such as; neurologic, orthopedic, psychiatric or/and systemic.

Primary outcomes:
measure: Postural stability score
timeFrame: at first minute, at the 2nd day, at the 15th day and at the30th day
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02546414: Platelet Count（PC）/Spleen Diameter(SD) Ratio to Predict the Variceal Haemorrhage in HBV Cirrhotic Patients in China
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Platelet Count/Spleen Diameter Ratio
Child-Pugh Classification
Keywords: Platelet count/spleen diameter ratio
China
Lead sponsor: RenJi Hospital
Sponsor class: OTHER
First posted: 2015-09-10
Enrollment: 150
Sex: ALL
Minimum age (years): 45
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: HBV cirrhotic patients in China

Brief summary: To validate the PC/SD ratio to be used to predict the variceal haemorrhage in Chinese patients with hepatitis B virus (HBV)-associated hepatic cirrhosis.

Detailed description: Esophageal variceal bleeding remains the leading cause of acute mortality in patients with cirrhosis. Using noninvasive parameters for high-risk variceal haemorrhage may reduce the need for endoscopies. The ratio of platelet count/diameter of the spleen (PC/SD ratio) is the principal noninvasive predictor of esophageal varices. This was an analytical cross-sectional study to validate the diagnostic test for HBV hepatic cirrhosis and was performed between January 2013 and August 2015. This study is to validate the PC/SD ratio to identification of those patients with high bleeding risk and selection for prophylactic treatment.

Eligibility criteria: Inclusion Criteria:

* Patients with a diagnosis of HBV hepatic cirrhosis

Exclusion Criteria:

* Patients with hepatocellular carcinoma,
* use of medications for the primary prophylaxis of variceal bleeding,
* history of esophageal variceal bleeding,
* alcohol consumption within the admission and a history of ligation,
* sclerotherapy, and/or
* portal hypertension surgery

Primary outcomes:
measure: Platelet count/spleen diameter ratio
timeFrame: up to 2.5 years
Secondary outcomes:
measure: Child-Pugh score.
timeFrame: up to 2.5 years
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Renji Hospital
state: Shanghai
Study officials:
References:
Clinical trial NCT02490514: A Study Of Mircera In Patients With Kidney Disease Who Are Not On Dialysis
Official title: Mircera In Patients With CKD Stages III-IV Not On Dialysis: Observational, Non-interventional Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Renal Tubular Acidosis, Distal, With Hemolytic Anemia
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2015-07-03
Enrollment: 153
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients 18 to 75 years old with stage III-IV chronic kidney disease not on dialysis

Brief summary: This open-label, non-randomized, retrospective-prospective, non-interventional study will evaluate the efficacy and safety of Mircera in patients with stage III-IV chronic kidney disease (CKD) not on dialysis. Patients will receive open-label treatment with Mircera for 12 months at a dose to be determined by the investigator.


Eligibility criteria: Inclusion Criteria:

* Patients with stage II-IV CKD not on dialysis, including renal transplant patients, who are receiving erythropoiesis-stimulating agent (ESA) treatment or are ESA-naive
* Patients who will not require dialysis within 12 months after the start of Mircera therapy
* Patients whose life expectancy is greater than 12 months after Mircera initiation
* Patients \>/= 18 years and \</= 75 years of age
* Patients who are female and of childbearing potential must be using effective contraception methods
* Patients with no contra-indications to ESA treatment (for example, hypersensitivity, non-controlled hypertension and others according to the local SmPC)
* Patients who have given written informed consent where local regulations allow or require it

Exclusion Criteria:

* Patients with stage I-II or stage V CKD
* Poorly controlled hypertension
* Active malignant disease

Primary outcomes:
measure: Percent Of Participants Who Reached And Maintained Target Hemoglobin Values During Treatment
timeFrame: 12 months
Secondary outcomes:
measure: Hb Levels At Start And End Of Treatment
timeFrame: 12 months
measure: Mircera Dose At Start And End Of Treatment
timeFrame: 12 months
measure: Time To Achieve Response To Mircera
timeFrame: 12 months
measure: Percent Of Participants Treated With Iron Supplements
timeFrame: 12 months
measure: Percent of Participants Who Required Transfusion At Start And End Of Treatment
timeFrame: 12 months
Other outcomes:
Locations:
city: Belgrade
country: Serbia
city: Cuprija
country: Serbia
city: Kragujevac
country: Serbia
city: NIS
country: Serbia
city: Pirot
country: Serbia
city: Pozarevac
country: Serbia
city: Sabac
country: Serbia
city: Sremska Mitrovica
country: Serbia
city: Uzice
country: Serbia
city: Zrenjanin
country: Serbia
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References:
Clinical trial NCT05051514: Physical Status of OSA Patients
Official title: Examination of Postural Stability, Quality of Life, Depression in Patients With Obstructive Sleep Apnea Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Lead sponsor: Okan University
Sponsor class: OTHER
Collaborators: name: Bitlis Eren University
First posted: 2021-09-21
Enrollment: 84
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Primary care clinic in Bitlis.

Brief summary: To investigate the differences in postural stability, anxiety/depression, and quality of life of the patients according to the severity of Obstructive Sleep Apnea Syndrome.


Eligibility criteria: Inclusion Criteria:

* Age \> 18 years old.
* Getting a diagnosis of OSAS with polysomnography.
* Agree to participate in the study.

Exclusion Criteria:

* Having respiratory system disease (COPD, asthma, bronchiectasis, lung cancer, etc.).
* Sedative, hypnotic drug intake. Use of medical supplements such as diazepam.
* Hypothyroidism, acromegaly.
* Diagnosis of a psychiatric illness.
* Uncontrolled arrhythmia causing symptoms or hemodynamic impairment.
* Pulmonary edema. Pregnancy.

Primary outcomes:
measure: Postural stability
timeFrame: Day 1.
Secondary outcomes:
measure: Anxiety and depression
timeFrame: Day 1.
Other outcomes:
measure: Quality of life evaluation
timeFrame: Day 1.
Locations:
city: Bitlis
country: Turkey
facility: Bitlis State Hospital
Study officials:
References:
Clinical trial NCT03556514: Follow-up for Locking Plate Fixaion of Distal Radius Fracture
Official title: Follow-up for Locking Plate Fixaion of Distal Radius Fracture
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Distal Radius Fracture
Keywords: Locking Plate Fixaion
Lead sponsor: Taipei Veterans General Hospital, Taiwan
Sponsor class: OTHER_GOV
First posted: 2018-06-14
Enrollment: 50
Sex: ALL
Minimum age (years): 24
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Acute distal humerus fracture after interlocking plate fixation

Brief summary: The current status of the disease under study. Including natural history, disease prognosis.

Distal radial fractures (DRF, distal radius fractures) are the most common fractures, allowing the user to lock the steel plate to accelerate the recovery of the wrist, but related injuries such as the triangular fibrocartilage cartilage complex (TFCC) tear or distal radius ulna joint (DRUJ) ligament tear with DRUJ instability requires time fixed or further repair surgery. If these issues are ignored, there will be weakness in the future. The ulnar shortening commonly used by hand surgeons is to improve the damage of TFCC or DRUJ instability. In the case of distal radial fracture combined with DRUJ instability, it is not clear that the distal radial fracture combined with DRUJ instability patients has long-term prognosis.


Eligibility criteria: Inclusion Criteria:

* Outpatient following for at least one year

Exclusion Criteria:

* (1) Injury or arthritis before; (2) Open fractures, or more wounds require surgery

Primary outcomes:
measure: 4-Item Pain intensity Measure
timeFrame: 5 seconds
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
Study officials:
affiliation: Taipei Veterans General Hospital, Taiwan
name: Jung-Pan Wang, M.D.,Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03200314: Blood Recirculation and vvECMO
Official title: Measurment of Blood Recirculation and Adjustment of vvECMO Blood Flow During Veno-venous Extracoporeal Membrane Oxygenation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: ARDS
Extracorporeal Membrane Oxygenation
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2017-06-27
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aged 18 years or older requiring veno-venous ECMO for treatment of refractory hypomxemia in ARDS.

Brief summary: A prospective, observational study will be performed measuring recirculation of blood through a veno-venous Extracoporeal Membrane Oxygenation (vvECMO) in patients with acute respiratory distress syndrome (ARDS) on vvECMO. ECMO blood flow will be adjusted with respect to recirculation.


Eligibility criteria: Inclusion Criteria:

* patients aged 18 years or older
* ARDS
* veno-venous ECMO

Exclusion Criteria:

* age \< 18 years
* hemodynamic instability during measurement of recirculation
* pregnancy
* inability to obtain patient's consent or consent of legal guardian

Primary outcomes:
measure: Recirculation of vvECMO blood flow
timeFrame: Once within first week after ICU admission during 4 hours
Secondary outcomes:
measure: Reduction of vvECMO blood flow
timeFrame: Once within first week after ICU admission during 4 hours
measure: Arterial blood oxygen content after reduction of vvECMO blood flow
timeFrame: Once within first week after ICU admission during 4 hours
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Charite University, Berlin, Germany
Study officials:
affiliation: Charite University Hospital Berlin
name: Martin Russ, Dr. med.
role: PRINCIPAL_INVESTIGATOR
affiliation: Charite University Hospital Berlin
name: Philipp A Pickerodt, Dr. med.
role: PRINCIPAL_INVESTIGATOR
affiliation: Charite University Hospital Berlin
name: Steffen Weber-Carstens, PD Dr. med.
role: PRINCIPAL_INVESTIGATOR
References: