Clinical trial NCT06863727: The Beijing Longitudinal Disability Survey in Community Elderly
Official title: The Beijing Longitudinal Disability Survey in Community Elderly
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Ageing
Disability
Cognitive Impairment
Frailty
Intrinsic Capacity
Keywords: Ageing
Disability
Cognitive Impairment
Community
Cohort
Lead sponsor: Xuanwu Hospital, Beijing
Sponsor class: OTHER
Collaborators: name: Beijing Municipal Health Commission
First posted: 2025-03-07
Enrollment: 1962
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community residents aged 65 years or older in Beijing

Brief summary: The goal of this observational study is to establish the prospective cohort of the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE) to explore the high-risk factors and preventive interventions for disability and cognitive impairment among community-dwelling adults aged 65 years and over. The main question it aims to answer is:

* What are the high-risk factors able to predict the incidence and advance of disability and cognitive impairment in community-dwelling adults aged 65 years and over?
* What are the categories of function and cognitive performance trajectory in community-dwelling adults aged 65 years and over?

Detailed description: BLINDSCE is a community-based prospective cohort study that includes individuals aged 65 and over from urban and rural areas in Beijing. Participants will provide detailed demographic information and undergo multifactorial questionnaires, disability measurements, cognitive assessments, other disability-related outcomes, and clinical biochemical measures. The study has started recruitment and enrollment in 2023 and will follow-up once every 1-2 year. This work consists of three steps as follows. First, by collecting baseline and follow-up data of participants, we plan to establish a community-dwelling elderly database in Beijing. Second, high-risk factors can be pre-screening based on this cross-sectional analysis. Third, longitudinal data was used to develop the prediction model and trajectory analysis for disability and cognitive impairment.

Eligibility criteria: Inclusion Criteria:

* Community-dwelling adults aged 65 years or older who reside in Beijing.
* Participants who sign an institutionally approved informed consent.

Exclusion Criteria:

* Participants with severe mental disorders and serious medical conditions preventing study investigation
* Participants undergoing long-term professional treatment for physical function and cognitive functioning, such as hospitalization or rehabilitation.

Primary outcomes:
measure: Disability from the individual's perspective
timeFrame: An average of 1 to 2 years
measure: Disability from the medical's perspective
timeFrame: An average of 1 to 2 years
measure: Disability from the medical's perspective
timeFrame: An average of 1 to 2 years
Secondary outcomes:
measure: Cognitive impairment
timeFrame: An average of 1 to 2 years
measure: Cognitive impairment
timeFrame: An average of 1 to 2 years
measure: Subjective cognitive decline
timeFrame: An average of 1 to 2 years
measure: Intrinsic capacity
timeFrame: An average of 1 to 2 years
measure: Intrinsic capacity
timeFrame: An average of 1 to 2 years
measure: Frailty
timeFrame: An average of 1 to 2 years
measure: Hospitalization
timeFrame: An average of 1 to 2 years
measure: Death
timeFrame: An average of 1 to 2 years
measure: Appendicular skeletal muscle mass
timeFrame: An average of 1 to 2 years
measure: Muscle strength
timeFrame: An average of 1 to 2 years
measure: Physical performance
timeFrame: An average of 1 to 2 years
measure: Sarcopenia
timeFrame: An average of 1 to 2 years
measure: Sarcopenia
timeFrame: An average of 1 to 2 years
Other outcomes:
Locations:
city: Beijing
country: China
facility: Xuanwu Hospital, Capital Medical University
Study officials:
affiliation: Beijing Geriatric Healthcare and Disease Prevention Center, Xuanwu Hospital, Capital Medical University
name: Yansu Guo, Ph.D
role: PRINCIPAL_INVESTIGATOR
References: