Clinical trial NCT03638323: Age-related Hearing Loss and Lexical Disorders
Official title: Pilot Study of the Links Between Presbyacusis and Lexical Disorders in Patients With Alzheimer's Disease or Related Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Alzheimer Disease
Presbycusis
Lexical Syntactic Disorder
Lead sponsor: Groupe Hospitalier de la Rochelle Ré Aunis
Sponsor class: OTHER
First posted: 2018-08-20
Enrollment: 46
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Series of patients from the Care Center for the Elderly (geriatric day hospital, long-term care units, follow-up care units and rehabilitation)

Brief summary: In France, Alzheimer's disease accounts for 70 to 80% of the causes of neurocognitive disorders, i.e. 600,000 to 800,000 patients. It is a neurodegenerative pathology that causes evolutionary cognitive dysfunction, mainly affecting memory functions. The inability to name familiar objects (lack of the word) is one of the most commonly noted symptoms at an early stage of the disease.

Presbyacusis, or age-related hearing loss, is the most common sensory deficit in the elderly which is manifested socially by a progressive discomfort of verbal communication. Presbyacusis remains underdiagnosed and undertreated: 2/3 of the patients are not using hearing aid.

In recent years, a link between neurocognitive disorders and hearing loss has been shown by investigating general cognition. In this study, the investigators are investigating lexical disorders.


Eligibility criteria: Inclusion Criteria:

* \> 65 years old
* French mother tongue
* Good vision with or without correction
* Alzheimer's or related disease (15 \<Mini-Mental State Examination\<25)
* Affiliate or beneficiary of a social security
* Informed consent

Exclusion Criteria:

* Cognitive disorders related to another pathology (cerebrovascular accident, head trauma, epilepsy ...)
* Protected patient (under guardianship) or person deprived of liberty by judicial or administrative decision

Primary outcomes:
measure: Link Between Lack of Word and Presbycusis
timeFrame: at inclusion
Secondary outcomes:
measure: Association Between Age and Lack of Word
timeFrame: at inclusion
measure: Association Between Gender and Lack of Word
timeFrame: at inclusion
measure: Association Between Study Level and Lack of Word
timeFrame: at inclusion
measure: Association Between Accommodation Type and Lack of Word
timeFrame: at inclusion
measure: Association Between Laterality and Lack of Word
timeFrame: at inclusion
measure: Association Between Main Diagnosis and Lack of Word
timeFrame: at inclusion
measure: Association Between Hearing Aid and Lack of Word
timeFrame: at inclusion
measure: Association Between Speech Therapy and Lack of Word
timeFrame: at inclusion
Other outcomes:
Locations:
city: La Rochelle
country: France
facility: Groupe Hospitalier de la Rochelle Ré Aunis
Study officials:
affiliation: Groupe Hospitalier de la Rochelle Ré Aunis
name: Marie-Laure Vignaud, Ph.D.
role: STUDY_DIRECTOR
References: