louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04388462: Comminuted Fractures of the Midshaft of the Tibia; (Interlocking Nail +/- Blocking Screws or Locked Plating With Predicted Distribution of Locking Screws) Choice Based on Finite Element Analysis Correlated With Clinical Outcome and Union.
Official title: Finite Element Analysis for Comminuted Fractures of the Midshaft of the Tibia; (Interlocking Nail +/- Blocking Screws or Locked Plating With Predicted Distribution of Locking Screws)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Comminuted Fracture Tibia
Keywords: Comminuted fracture, Finite element analysis, Tibia
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-05-14
Enrollment: 20
Sex: ALL
Minimum age (years): 25
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patient with comminuted fractures of the midshaft of the tibia.

Brief summary: study is to assess the clinical and radiological results of Comminuted fractures of the midshaft of the tibia; treated with interlocking nail +/- blocking screws or locked plating with predicted distribution of locking screws, choice based on finite element analysis correlated with clinical outcome and union.

Detailed description: FE analyses will be performed using the finite element code COSMOS/M. The three-dimensional "lower leg" FE model (LL FE model) will be used included the tibia and the fibula. The bony structures will be generated by segmentation of a data set of computed tomographies from the Visible Human Project.

Analysis of data regarding clinical outcomes and radiological assessment of healing rate and union

Eligibility criteria: Inclusion Criteria:

1. patients with closed comminuted fractures of the midshaft of the tibia
2. patients with age ranging from 25 to 45 years old

Exclusion Criteria:

* 1- Simple fractures of the midshaft of the tibia. 2- patients with open comminuted fractures of the midshaft of the tibia. 3- critical and ICU patients. 4- patients with ipsilateral lower limb fractures.

Primary outcomes:
measure: Healing of the fracture
timeFrame: 3 month
measure: Tibia Pain
timeFrame: 3 month
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Sahar
Study officials:
References:
Clinical trial NCT06032962: Opportunistic Salpingectomy in Non-gynecological Surgeries
Official title: Opportunistic Salpingectomy in Non-gynecological Surgeries - a Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ovarian Cancer Prevention
Lead sponsor: Meir Medical Center
Sponsor class: OTHER
First posted: 2023-09-13
Enrollment: 42
Sex: FEMALE
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The goal of this study is to evaluate patient's compliance for opportunistic salpingectomy (OS) and procedure feasibility in non gynecological abdominal surgeries

Detailed description: Patients who are candidate for non-gynecological abdominal surgery, are offered OS. If agree, a general surgeon perform the procedure during the planned abdominal surgery

Eligibility criteria: Inclusion Criteria:

* Women who were candidates for non-gynecological abdominal surgery
* Aged 45 or older, or aged 40 or older with a desire for bilateral salpingectomy

Exclusion Criteria:

* Pregnant women
* Candidates for urgent surgery

Primary outcomes:
measure: patients willing for salpingectomy
timeFrame: day of enrollment
measure: patients undergoing salpingectomy
timeFrame: from enrollment and up to 6 weeks
measure: length of salpingectomy
timeFrame: within surgery
measure: surgical complications
timeFrame: up to 30 days from surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Kfar Saba
country: Israel
facility: Meir medical center
Study officials:
References:
Clinical trial NCT04736862: Impact of Continuous Non-invasive Blood Pressure Monitoring on Hypotension in Patients Having Non-cardiac Surgery
Official title: The Impact of Continuous Non-invasive Blood Pressure Monitoring on Post-induction and Intraoperative Hypotension in Patients Having Non-cardiac Surgery (DETECT Trial): A Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Blood Pressure
Perioperative Hypotension
Lead sponsor: Universitätsklinikum Hamburg-Eppendorf
Sponsor class: OTHER
First posted: 2021-02-03
Enrollment: 242
Sex: ALL
Minimum age (years): 45
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This is a randomized trial (1) investigating whether continuous non-invasive finger-cuff blood pressure monitoring reduces the area under a mean arterial pressure (MAP) of 65 mmHg within the first 15 minutes of anesthetic induction compared to intermittent blood pressure monitoring using upper-arm cuff oscillometry in patients having non-cardiac surgery; and (2) investigating whether continuous non-invasive finger-cuff blood pressure monitoring reduces the time-weighted average for MAP \<65 mmHg during the intraoperative period compared to intermittent blood pressure monitoring using upper-arm cuff oscillometry in patients having non-cardiac surgery.

Detailed description: not provided

Eligibility criteria: Inclusion Criteria:

* Patients at least 45 years of age scheduled for elective non-cardiac surgery with general anesthesia are eligible for study inclusion if blood pressure monitoring using intermittent upper-arm cuff oscillometry is planned.

Exclusion Criteria:

* Emergency surgery,
* pregnancy,
* American Society of Anesthesiologists (ASA) physical status classification V or VI, blood pressure differences between the right and left arm of more than 20 mmHg, intraoperative invasive blood pressure monitoring, heart rhythms other than sinus rhythm.

Primary outcomes:
measure: Area under a MAP of 65 mmHg within the first 15 minutes of anesthetic induction between the intervention and the control group.
timeFrame: 15 min
measure: Time-weighted average for MAP <65 mmHg during the intraoperative period between the intervention and the control group.
timeFrame: intraoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Hamburg
country: Germany
facility: Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf
Study officials:
affiliation: Universitätsklinikum Hamburg-Eppendorf
name: Karim Kouz, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01109862: Prospective Randomized Comparison of Bipolar Hemiarthroplasty and Total Hip Arthroplasty With Large Femoral Heads for the Treatment of Displaced Intracapsular Femoral Neck Fractures in the Elderly
Official title: Prospective Randomized Comparison of Bipolar Hemiarthroplasty and Total Hip Arthroplasty With Large Femoral Heads for the Treatment of Displaced Intracapsular Femoral Neck Fractures in the Elderly
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Femoral Neck Fractures
Keywords: Femoral neck fractures
Hip fractures
Elderly
Total hip arthroplasty
Bipolar hemiarthroplasty
Lead sponsor: Wolfson Medical Center
Sponsor class: OTHER_GOV
First posted: 2010-04-23
Enrollment: 80
Sex: ALL
Minimum age (years): 70
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare hemiarthroplasty (HAP) with total hip arthroplasty (THA), performed by trained arthroplasty surgeons with the use of large femoral heads for the treatment of displaced femoral neck fractures in mobile independent elderly patients, to determine the impact of these surgical options on the short term functional outcomes and complication rates, namely dislocation and the need for further surgery.

This is a single-blinded prospective randomized clinical trial comparing functional outcome and complication rates of 40 patients treated with all cemented THA to a control group of 40 patients treated with cemented bipolar HAP, in a 2 years followup.

The primary endpoint is the Oxford hip score (OHS) at last followup as a measure of functional outcome. Secondary endpoints include the SF-36 score, walking distance and rates of postoperative dislocation, component loosening, need for revision and postoperative mortality.


Eligibility criteria: Inclusion Criteria:

* 1. Acute femoral neck fracture.
* 2. Age between 70 and 90 years old.
* 3. Independent community ambulator (more than 0.5km, without the aid of another person. The use of a cane is permitted) prior to fracture.
* 4. Abbreviated mental test score \> 6 .

Exclusion Criteria:

* 1. Pathological fracture (excluding osteoporosis).
* 2. Rheumatoid arthritis.
* 3. Symptomatic arthrosis of the involved hip.
* 4. Neurological disorder that may significantly influence walking ability and/or tendency to dislocate.
* 5. Chronic corticosteroid use.
* 6. Concomitant other fracture.
* 7. Very high surgical risk.

Primary outcomes:
measure: Oxford hip score (OHS)
timeFrame: last followup - 2 years
Secondary outcomes:
measure: SF-36 score, walking distance
timeFrame: 2 years followup
measure: dislocation rate, mortality rate
timeFrame: within follow up - 2 years
Other outcomes:
Locations:
city: Holon
country: Israel
facility: Orthopaedic dept., E. Wolfson Medical center
Study officials:
affiliation: E. Wolfson medical center
name: Dror Lakstein, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT07004062: Application Value of Targeted Nursing Based on Risk Assessment Strategies in the Treatment of Patients With Gynecological Endocrine Disorders
Official title: Application Value of Targeted Nursing Based on Risk Assessment Strategies in the Treatment of Patients With Gynecological Endocrine Disorders
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Gynecological Endocrine Disorders
Risk Assessment
Targeted Nursing Care
Psychological Support
Quality of Life
Lead sponsor: Obstetrics and Gynecology Hospital of Fudan University-Huangpu Campus
Sponsor class: OTHER_GOV
First posted: 2025-06-04
Enrollment: 154
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Risk-based targeted nursing significantly enhances clinical outcomes, quality of life, and mental health in patients with gynecological endocrine disorders, supporting its broader clinical application.

Detailed description: To evaluate the clinical value of targeted nursing care based on risk assessment in patients with gynecological endocrine disorders.

A prospective controlled study was conducted to analyze the clinical data of 84 patients with endocrine disorders and 89 healthy women, focusing on identifying risk factors associated with endocrine disorders and designing corresponding personalized nursing interventions. A total of 154 patients with gynecological endocrine disorders, treated between December 2023 and June 2024, were randomly assigned into a control group (n = 77) and an observation group (n = 77) using a random number table method. The control group received routine nursing care, while the observation group received targeted nursing interventions based on risk assessment strategies in addition to routine care. Nursing outcomes, patient satisfaction, quality of life scores, and psychological status-including Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores-were compared between the two groups.

Eligibility criteria: Inclusion Criteria:

Clinical diagnosis of gynecological endocrine disorder

Aged 18-45 years

Complete clinical data available

Willing and able to provide informed consent

Exclusion Criteria:

Severe systemic or psychiatric illness

Recent major surgery or hormonal/fertility treatment (within 3 months)

Known hypersensitivity to study medications

Currently pregnant or breastfeeding

Participation in another clinical trial within 6 months

Primary outcomes:
measure: Clinical Efficacy of Targeted Nursing in Gynecological Endocrine Disorders
timeFrame: Baseline to 6 months post-intervention.
Secondary outcomes:
measure: Patient Satisfaction with Nursing Care
timeFrame: End of intervention (Week 12).
Other outcomes:
measure: Adherence to Lifestyle Interventions
timeFrame: Weekly during intervention (Weeks 1-12).
Locations:
city: Shanghai
country: China
facility: Obstetrics and Gynecology Hospital of Fudan University
state: Shanghai
Study officials:
References:
Clinical trial NCT03297762: Increasing Use of Continuous Glucose Monitors in Publicly-insured Youth With Type 1 Diabetes
Official title: Improving Adherence to Continuous Glucose Monitors in Publicly-insured Youth With Type 1 Diabetes
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Type1diabetes
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2017-09-29
Enrollment: 4
Sex: ALL
Minimum age (years): 13
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: To use an enhanced continuous glucose monitor (CGM) experience, including an automated CGM-electronic health record (EHR) data integration system, proactive interventions, and gamification techniques, to increase CGM use among publicly-insured youth with type 1 diabetes (T1D).

Detailed description: The investigators will use an automated data integration system to monitor hours per week the CGM is worn and target interventions/troubleshooting techniques as needed. The investigators will use gamification techniques (i.e. ability to gain points and achieve small rewards) to help encourage CGM use and potentially improve glycemic control in this at-risk population.

Eligibility criteria: Inclusion Criteria:

* type 1 diabetes for more than 6 months
* on insulin pump or multiple daily injections without plans to change modality in next 6 months
* insured by CCS or Medi-Cal
* receiving care at Lucile Packard Children's Hospital or Stanford Children's Health outpatient clinics
* English or Spanish-speaking

Exclusion Criteria:

* major illness or condition that may alter glucose control or ability to complete the study including pregnancy, cystic fibrosis, cancer, liver disease, history of transplant, or hemoglobinopathy
* current oral glucocorticoid use
* prior use of a CGM system
* hemoglobin A1C \<7.5% or \>12%
* no wireless internet access

Primary outcomes:
measure: CGM use
timeFrame: baseline to 6 months
Secondary outcomes:
measure: Hgb A1c
timeFrame: baseline to 6 months
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford Children's
state: California
Study officials:
affiliation: Stanford University
name: Maria Chang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06869980: Efficacy of Limited Right Anterior Thoracotomy Versus Median Sternotomy for Mitral Valve Replacement
Official title: Efficacy of Limited Right Anterior Thoracotomy Versus Median Sternotomy for Mitral Valve Replacement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Minimal Invasive Cardiac Surgery
Limited Right Anterior Thoracotomy for Mitral Valve Replacement
Keywords: mitral valve replacement
Limited Right Anterior Thoracotomy
median sterntomy
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
First posted: 2025-03-11
Enrollment: 41
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: this study compare between two diffrent methods for approach mitral valve in mitral valve replacement throgh opening of the middle of the sternum by saw or through opening between 4th and 5th rib on the right side of the chest without saw

Detailed description: study the efficacy of mitral valve replacement by median sterntomy versus limited right thoractomy

Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with acquired isolated mitral valve disease requiring mitral valve replacement \> 18 years

Exclusion Criteria:

* patients with Previous cardiac surgery, • Patients less than 18 years, • Patients with other valvular heart lesions (aortic valve or tricuspid valve) , IHD Patients , Obese patients (BMI\>35), COPD patients

Primary outcomes:
measure: length of skin incision (cosmotic scar)
timeFrame: 1 week after surgery
measure: post operative pain threshold (Visual analog scale (VAS):0 to 10 assess pain from no pain-mild -moderate- sever-worst pain possible
timeFrame: 5 days after surgery
measure: wound satisfaction scale (quality of life questionnaire)
timeFrame: 2 weeks after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Zagazig
country: Egypt
facility: Mohamed Samy Abdalla
state: El sharkia
Study officials:
affiliation: cardiothoracic surgery department-faculty of medecine-Zagazig univeristy-Egypt
name: Mohamed Sa Abdalla, lecturer
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04189380: Therapeutic Literacy Evaluation in Liver Transplanted Patients
Official title: Therapeutic Literacy Evaluation in Liver Transplanted Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Health Literacy
Liver Transplantation
Keywords: Health literacy
liver transplanted patients
cognitive evaluation
social status
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2019-12-06
Enrollment: 53
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: Health literacy is a new concept in therapeutic patient education. Health Literacy has been defined as the cognitive and social skills which determine the motivation and ability of individuals to gain access to, understand and use information in ways which promote and maintain good health. Health literacy seems predictive of adherence 's patients to treatment or positive health behavior.

Liver transplanted patients need to modify their lifestyle and to perform new behaviors in order to improve their survival and their quality of life. Health literacy evaluation in these patients is necessary to know what they understand and to improve their intake.

The Aim of the study is to evaluate health literacy among liver transplanted patient and to perform liver transplanted patient profiles related to their own health literacy.

The second aim is to study the impact of health literacy on medication adherence and iatrogenic hospitalizations It is a monocentric non-randomized study. During the hepatologist consultation, the HLQ Health Literacy Questionnaire is performed to explore patient health understanding and perception. Then the pharmacist interviews the patient to explore motivations and brakes for their own healthcare; Furthermore, a cognitive and precarity evaluation is performed in order to analyze psychological or social factors which can influence health literacy.

Detailed description: Tests performed:

* Health Literacy Questionnaire: HLQ
* Montreal Cognitive Evaluation Assessment: MoCA
* EPICES: precarity test validated in French
* A qualitative interview

Eligibility criteria: Inclusion Criteria:

* Adult patient \> 18 years
* Liver transplanted patient \> 1 year at the start of the study
* patient who are followed-up by an hepatologist in the center
* patient who understands and speaks French

Exclusion Criteria:

* patient not yet liver transplanted (on the waiting-list)
* patient who has not come back home yet
* patient who does not speak or understand French
* patient refusal to participate
* patient under supervision or guardianship

Primary outcomes:
measure: health literacy questionnaire
timeFrame: day 1
Secondary outcomes:
measure: MoCA questionnaire
timeFrame: day 1
measure: EPICES questionnaire
timeFrame: day 1
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: Chu Clermont Ferrand
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Sarah Talavera
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05025280: Sensory Processing Patterns in Hearing Loss
Official title: Sensory Processing Patterns in Adults With Acquired Hearing Loss
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hearing Loss
Keywords: Adult
Hearing loss
sensory processing
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2021-08-27
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: According to the audiological test results, individuals with a pure tone average of more than 25 dB in the better ear and with less than 10 dB difference between the air-bone conduction thresholds

Brief summary: This study aimed to evaluate the sensory processing abilities of adults with acquired hearing loss and to explore the differences in sensory processing between adults with hearing loss and adults with normal hearing. Sensory processing functions of 30 adults with acquired hearing loss will be evaluated using the Adolescent/Adult Sensory Profile. The data from adults with hearing loss will be compared with data from 30 adults with normal hearing who were similar in gender and age.

Detailed description: This study aims to investigate the sensory processing patterns of adults with hearing loss and compare them with healthy controls. In this study, it was hypothesized that adults with hearing loss, had an abnormal sensory profile like children with hearing loss.

Participants will consist of individuals between the ages of 18-65 who were taken into audiological evaluation at the outpatient unit of Audiology of a hospital and voluntarily agreed to participate in the study.

According to the audiological test results, individuals with a pure tone average of more than 25 decibel (dB) in the better ear and with less than 10 dB difference between the air-bone conduction thresholds will be included in the study group, and those with a pure tone average of 25 dB or less in both ears and with less than 10 dB difference between the air-bone conduction thresholds will be included in the control group.

Hearing aid users, those with chronic tinnitus and/or dizziness, and those with major medical disorders and/or handicaps will not be included in the study. In this study, Hearing Handicap Inventory for Adults (HHIA) and Adolescent/Adult Sensory Profile will be used.

Eligibility criteria: Inclusion Criteria:

* adults with acquired sensorineural hearing loss for study group
* adults with normal hearing for control group

Exclusion Criteria:

* Hearing aid users
* adults with chronic tinnitus and/or dizziness
* adults with major medical disorders and/or handicap

Primary outcomes:
measure: Adolescent/Adult Sensory Profile scores
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University
Study officials:
affiliation: Hacettepe University
name: Gonca Bumin, Prof.
role: STUDY_DIRECTOR
References: