Clinical trial NCT03308838: A Case-control Study of Costa Rican Adults With Myocardial Infarction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myocardial Infarction, Acute
Lead sponsor: University of Michigan
Sponsor class: OTHER
Collaborators: name: Universidad de Costa Rica
name: Harvard School of Public Health (HSPH)
First posted: 2017-10-13
Enrollment: 4547
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Cases were survivors of a first acute MI as diagnosed by a cardiologist at any of the six recruiting hospitals in the Central Valley of Costa Rica. Controls were population-based controls from Costa Rica.

Brief summary: This observational case-control trial sought to identify and characterize different exposures associated with nonfatal acute myocardial infarction in Costa Rican adults. Exposures assessed included dietary variables and adipose tissue fatty acids.


Eligibility criteria: Inclusion Criteria:

* Cases were eligible if they met the World Health Organization criteria for MI

Exclusion Criteria (Cases):

* Died during hospitalization
* Were 75 years or older on the day of their first MI
* Were physically or mentally unable to answer the questionnaire
* Had a previous hospital admission related to cardiovascular disease

Exclusion Criteria (Controls):

* Ever had an MI
* Were physically or mentally unable to answer the questionnaire

Primary outcomes:
measure: Nonfatal Acute Myocardial Infarction
timeFrame: 1994-2004
Secondary outcomes:
Other outcomes:
Locations:
city: San Pedro
country: Costa Rica
facility: University of Costa Rica
state: San José
Study officials:
affiliation: University of Michigan
name: Ana Baylin, MD, DrPH
role: PRINCIPAL_INVESTIGATOR
References:
citation: El-Sohemy A, Baylin A, Spiegelman D, Ascherio A, Campos H. Dietary and adipose tissue gamma-tocopherol and risk of myocardial infarction. Epidemiology. 2002 Mar;13(2):216-23. doi: 10.1097/00001648-200203000-00018.
citation: Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. Circulation. 2003 Apr 1;107(12):1586-91. doi: 10.1161/01.CIR.0000058165.81208.C6. Epub 2003 Mar 10.
citation: Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. High 18:2 trans-fatty acids in adipose tissue are associated with increased risk of nonfatal acute myocardial infarction in costa rican adults. J Nutr. 2003 Apr;133(4):1186-91. doi: 10.1093/jn/133.4.1186.
citation: Kabagambe EK, Baylin A, Campos H. Nonfatal acute myocardial infarction in Costa Rica: modifiable risk factors, population-attributable risks, and adherence to dietary guidelines. Circulation. 2007 Mar 6;115(9):1075-81. doi: 10.1161/CIRCULATIONAHA.106.643544.
citation: Aslibekyan S, Campos H, Loucks EB, Linkletter CD, Ordovas JM, Baylin A. Development of a cardiovascular risk score for use in low- and middle-income countries. J Nutr. 2011 Jul;141(7):1375-80. doi: 10.3945/jn.110.133140. Epub 2011 May 11.
citation: Wang D, Campos H, Baylin A. Red meat intake is positively associated with non-fatal acute myocardial infarction in the Costa Rica Heart Study. Br J Nutr. 2017 Aug;118(4):303-311. doi: 10.1017/S000711451700201X.