louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06354855: "Which Type of Exercise is More Effective in Chronic Constipation?
Official title: "Which Type of Exercise is More Effective in Chronic Constipation? (Randomized Controlled Study)"
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Chronic Constipation
Lead sponsor: Necmettin Erbakan University
Sponsor class: OTHER
First posted: 2024-04-09
Enrollment: 54
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two groups with a conventional therapy control group
Primary purpose: TREATMENT

Brief summary: In this study, it will be investigated whether a daily 30-minute walk or abdominal breathing exercise is more effective on chronic constipation.

Detailed description: According to the results of population-based studies conducted in our country, the frequency of constipation varies between 22-40%. In addition to medical treatment, alternative treatments are frequently used in the treatment of constipation. One of these is exercise.

In addition to medical treatment, alternative treatments are frequently used in the treatment of constipation. One of these is exercise. Many traditional breathing techniques developed in Asia are thought to be beneficial to health. In the light of this information, it is aimed to monitor ActiGraph GT3X+ Accelerometer, which is an objective measurement method of physical activity, and to evaluate the effectiveness of breathing exercise, which is one of the abdominal breathing exercises.

Eligibility criteria: Inclusion Criteria:

* Able to speak and understand Turkish,
* Voluntarily accepted to participate in the research and written consent form was obtained (those who could fill out the forms themselves using their hands, and those who could not use it, from their relatives with verbal consent),
* At least 18 years of age and over,
* Oriented to place, person and time,
* Patients who do not have spinal cord injury, parapilegia, or quadriplegia that may physiologically impede the individual's intestinal excretion Does not have any problems that prevent cognitive, sensory and verbal communication,
* Patients who are conscious and not using any sedating medication
* men and women aged 20-80 at the time of approval

Exclusion Criteria:

* pregnancy or possible pregnancy;
* the habit of doing all kinds of breathing exercises;

Primary outcomes:
measure: Visual Analog Scale (VAS)
timeFrame: two months
Secondary outcomes:
measure: Constipation Severity Scale (CSS)
timeFrame: two months
Other outcomes:
measure: Chronic Constipation Quality of Life Scale
timeFrame: two months
Locations:
city: Konya
country: Turkey
facility: Faculty of Nezahat Keleşoğlu Health Sciences Necmettin Erbakan University
state: Meram
Study officials:
affiliation: Necmettin Erbakan University
name: Fatma Erdeo, Ph D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01041014: Cost Effectiveness of Language Services in Hospital Emergency Departments (EDs)
Official title: Cost Effectiveness of Language Services in Hospital Emergency Departments
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Language Discordance
Keywords: Limited English proficiency
Cost-effectiveness
Emergency Departments
Language Discordance
Satisfaction
Limited English proficient patients
Spanish-speaking patients
Lead sponsor: Mathematica Policy Research, Inc.
Sponsor class: OTHER
Collaborators: name: Robert Wood Johnson Foundation
First posted: 2009-12-30
Enrollment: 447
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Numerous studies suggest that the use of in-person, professionally trained medical interpreters can reduce health care costs associated with diagnosing and treating patients with limited English proficiency. However, few studies have specifically addressed the question of the cost-effectiveness of language services in health care settings. This study used a randomized controlled study design to compare the cost-effectiveness of using professional interpreters with Spanish-speaking patients seen in hospital emergency departments (EDs) versus using the usual language services available to these patients. The main goal of the study was to estimate the effect that professional interpreters have on resource utilization and patient/provider satisfaction in the ED compared to the language services usually offered in these settings. Our hypothesis was that use of trained interpreters would lead to more cost-effective provision of ED services.


Eligibility criteria: Inclusion Criteria:

* limited English proficient (LEP) Spanish-speaking patients
* adults aged 18 or older
* LEP parents of children seen in emergency departments

Exclusion Criteria:

* cognitively impaired, comatose, or traumatized patients
* healthy volunteers
* prisoners
* hospital employees

Primary outcomes:
measure: Cost-effectiveness of in-person interpreters versus other language services
timeFrame: June 2009
Secondary outcomes:
measure: Satisfaction with ability to communicate
timeFrame: June 2009
Other outcomes:
Locations:
city: Freehold
country: United States
facility: CentraState Healthcare System
state: New Jersey
city: New Brunswick
country: United States
facility: Robert Wood Johnson University Hospital
state: New Jersey
Study officials:
affiliation: Mathematica Policy Research
name: Ann D Bagchi, Ph.D.
role: STUDY_DIRECTOR
affiliation: Mathematica Policy Research
name: Stacy Dale, MPA
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Medicine and Dentistry of New Jersey
name: Robert Eisenstein, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06744114: Etiologies, Definitive Diagnosis and Patient Outcomes in Altered Level of Consciousness in the Emergency Department
Official title: Etiologies, Definitive Diagnosis and Patient Outcomes in Altered Level of Consciousness in the Emergency Department
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Consciousness Disorders
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-12-20
Enrollment: 1
Sex: ALL
Minimum age (years): 19
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Definitive Diagnosis and Patient Outcomes in Altered Level of Consciousness in the Emergency Department

Brief summary: When someone starts acting differently in terms of how alert or awake they are, it can be a tough situation for emergency (ER) department doctors.e exact and definitive etiologies of ALOC that can be intracranial or extracranial.

Detailed description: The change in terms of mental state in accordance with how alert and awake patient is termed as altered level of consciousness. Etiologies will be classified by using convenience sampling. GCS\<14 patients will be included in this study. Data will be collected through a slight modification in a pre-designed Performa. Reference point for the data collection will be the time of discharge from the emergency department. In Previous studies mostly, etiologies were classified as extracranial and intracranial. Some studies found neurological etiologies most dominant as an extra cranial and some studies found systematic infections ,metabolic causes and some demonstrated that intracranial etiologies were dominant. So, in this study we will find the definitive diagnosis in patient having ALOC which can be intracranial or extracranial. And also, it will be compared with GCS scale. This study will identify th

Eligibility criteria: Inclusion Criteria:

* Patients with GCS\<15, age group 18 years to 90 years which come in emergency department due to any etiology will be included in this study.

Exclusion Criteria:

* GCS = 15 will be excluded from the study.
* patients coming in any outpatient department setting or other than emergency department and age group \<18 or \> 90 will be excluded from this study.

Primary outcomes:
measure: GCS(GLASGOW COMMA SCALE)
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Kashmir
country: Pakistan
facility: CMH RAWALAKOT AJK, District poonch , tehsil Rawalakot, AJK PAKISTAN
state: Punjab
Study officials:
References:
Clinical trial NCT01440114: The Effect of Intravenous Fentanyl Prior the End of Surgery on Emergence Agitation in Paediatric Patients After General Anesthesia
Official title: The Effect of Intravenous Fentanyl Prior the End of Surgery on Emergence Agitation in Paediatric Patients After General Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Agitation
Keywords: emergence agitation
pediatric patient
fentanyl
incidence of emergence agitation
severity of emergence agitation
adverse outcome from intervention
Lead sponsor: Prince of Songkla University
Sponsor class: OTHER
First posted: 2011-09-26
Enrollment: 144
Sex: ALL
Minimum age (years): 2
Maximum age (years): 9
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The propose of this study is to determine the effect of intravenous fentanyl prior the end of surgery on the incidence and severity of EA in pediatric patient.

Detailed description: Emergence agitation (EA) is a common self limiting problem after emerging from general anesthesia (GA) especially in pediatric patients. The incidence of EA in Thai population, the incidences of EA 43.2% in pediatric patients aged between 2-9 years. There have been many studies tried to reduce the incidence of EA in various ways such as Preoperative anxiety reduction method and medication. Premedication, Sedative drugs and narcotic drugs were used to reduce the incidence of EA.

Eligibility criteria: Inclusion Criteria:

* Aged between 2-9 years
* IPD patient
* Receiving Chloral hydrate 50mg/kg (BW\<20 kgs)or midazolam 0.1 mg /kg (BW\>20 kgs)Per oral for premedication
* Scheduled for one kind of these surgeries; Otolaryngology, Ophthalmology, Urology, Orthopedic,General surgery, Plastic surgery and Cardiac catheterization.

Exclusion Criteria:

* ASA physical status IV-V
* History of drug allergy:thiopental, fentanyl cisatracurium, chloral hydrate and diazepam

Primary outcomes:
measure: the incidence of emergence agitation
timeFrame: pt was observed since emerging from anesthesia up to 60 minutes
Secondary outcomes:
measure: severity of emergence agitation
timeFrame: pt was observed since emerging from anesthesia up to 60 minutes
measure: adverse effect from intravenous fentanyl prior the end of surgery
timeFrame: pt was observed since emerging from anesthesia upto 60 minutes
measure: post operative pain
timeFrame: pt was observed since emerging from anesthesia up to 60 minutes
Other outcomes:
Locations:
city: Hat-Yai
country: Thailand
facility: Faculty of Medicine, Prince of Songkla University
state: Sonkhla
Study officials:
References:
Clinical trial NCT00843414: Immunological Characterization of Bronchoalveolar Cells in Normals
Official title: Immunological Characterization of Bronchoalveolar Cells in Normals
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Disease
Keywords: Emphysema
Sarcoidosis
Interstitial Pulmonary Fibrosis
Lead sponsor: Ohio State University
Sponsor class: OTHER
First posted: 2009-02-13
Enrollment: 1232
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: community sample

Brief summary: To obtain the monocytes (white blood cells) from normal volunteers for the purpose of studying how proteins, fats, carbohydrates, as well as RNA and DNA for gene expression, relate to immunity. This information will be compared to other studies in patients with lung diseases such as Emphysema, Sarcoidosis, and Interstitial Pulmonary Fibrosis.

Detailed description: To determine the functional capabilities of cells obtained from bronchoalveolar lavage fluid and peripheral blood monocytes from normal individuals. The ongoing objective varies from investigation to investigation but in general the investigational goals are to better understand the immune function of monocytes purified from normal volunteers. In some instances the emphasis will be upon comparing the specific immune function (e.g. ability to sense endotoxin and release a cytokine) from blood monocytes as compared to human alveolar macrophages. This comparison is not the only goal of the study, however. In many cases the immune function of the monocyte will be sufficient in and of itself as an investigational goal. In other cases the same is true of alveolar macrophage function.

Eligibility criteria: Inclusion Criteria:

* healthy

Exclusion Criteria:

* unable to consent

Primary outcomes:
measure: comparing the specific immune function (e.g. ability to sense endotoxin and release a cytokine) from blood monocytes as compared to human alveolar macrophages
timeFrame: end of study
Secondary outcomes:
measure: Analysis of lung proteins present in BAL fluid
timeFrame: end of study
Other outcomes:
Locations:
city: Columbus
country: United States
facility: The Ohio State University
state: Ohio
Study officials:
affiliation: Ohio State University
name: Mark D Wewers, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04996914: Adjuvant Stereotactic Body Radiation Therapy After Trans-arterial Chemoembolization in Hepatocellular Carcinoma
Official title: Adjuvant Stereotactic Body Radiation Therapy After Trans-arterial Chemoembolization in Hepatocellular Carcinoma
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Hepatocellular Carcinoma Non-resectable
Lead sponsor: RWTH Aachen University
Sponsor class: OTHER
First posted: 2021-08-09
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The study investigates the adjuvant SBRT following TACE in early and intermediate stages HCC not amenable for surgical resection or orthotopic liver transplant.


Eligibility criteria: Inclusion Criteria:

* HCC (diagnosis: histological or radiological)
* Age: 18-80
* Number of lesions 1-3 lesions
* Size of the lesion (or sum of 2-3 lesions) ≥ 4 cm
* Sufficient non-tumorous liver volume (≥ 800 cm3)
* Child Pugh Score: A5-6 or B7-8
* BCLC A or B
* Patient is illegible or refused surgical resection or orthotopic liver transplant
* Blood work (within 2 weeks before registration):
* Absolute neutrophil count (ANC) ≥ 1,500 cells/mm³)
* Platelets ≥50,000 cells/mm³
* AST (and ALT) \< 5 times ULN
* Serum creatinine ≤ ULN or creatinine clearance ≥ 50 mL/min

Exclusion Criteria:

* Evidence of extrahepatic disease (lymph node or distant metastases)
* Evidence of macroscopic vascular invasion
* Evidence of an arterio-portal or arterio-venous fistulas
* History of previous malignancy
* Previous SIRT
* Previous Sorafenib in the last 8 weeks
* Pregnant and lactating females

Primary outcomes:
measure: 1-year local control rate
timeFrame: 12 Months
Secondary outcomes:
measure: Qualtiy of life based on EORTC QLQC30
timeFrame: 12 Months
measure: 1- year progression free survival
timeFrame: 12 Months
measure: Quality of life based on EORTC QLQ-HCC18
timeFrame: 12 Months
Other outcomes:
Locations:
Study officials:
affiliation: University medical center RWTH Aachen
name: Michael J. Eble, Professor Dr. med.
role: STUDY_CHAIR
affiliation: University medical center RWTH Aachen
name: Philipp Bruners, Professor Dr. med.
role: STUDY_CHAIR
affiliation: University medical center RWTH Aachen
name: Ahmed Allam Mohamed, MBBS, MSc, MD
role: STUDY_CHAIR
affiliation: University medical center RWTH Aachen
name: Oliver Beetz, Prof. Dr.med . MHBA
role: STUDY_CHAIR
affiliation: University medical center RWTH Aachen
name: Marie-Luise Berres, Prof. Dr.med.
role: STUDY_CHAIR
References:
Clinical trial NCT06624514: mHealth Behavior Study
Official title: Mobile Health Reaction Time and Behavior Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Alcohol Consumption
Condom Use
Keywords: Alcohol
condoms
Sexual Assault
Risky Sex
Lead sponsor: Medical University of South Carolina
Sponsor class: OTHER
First posted: 2024-10-03
Enrollment: 46
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to learn if a brief task completed on a smartphone can reduce alcohol use and risky sexual behavior among women between the ages of 18 and 25 who have a history of experiencing sexual assault or an unwanted sexual experience. The main questions it aims to answer are:

* Does the smartphone task change approach biases for alcohol and condom-related images?
* Does the smartphone task reduce alcohol use and risky sexual behavior?

Researchers will compare the smartphone task to a sham control to see if the smartphone task changes biases and behavior.

Participants will:

* Complete a baseline assessment battery of questionnaires
* Complete either the intervention smartphone task or the sham smartphone task on four consecutive days.
* Complete a follow-up assessment one week after finishing the four tasks
* Complete a three-month follow-up


Eligibility criteria: Inclusion Criteria:

* Adult women who report lifetime experience sexual assault,
* Consume alcohol at least moderately (e.g., at least seven drinks per week; NIAAA, 2015),
* Have engaged in sexual intercourse with a casual, non-committed male partner without a condom at least three times during the three months prior to data collection.

Exclusion Criteria:

* Active homicidal or suicidal ideation;
* History of or current psychotic disorders as the study protocol may be therapeutically insufficient;
* Previously identified as having a Pervasive Developmental Disability.

Primary outcomes:
measure: Approach Bias
timeFrame: 3-months post final intervention session
measure: Condom Use
timeFrame: Three-Months
measure: Alcohol Use
timeFrame: Three-Months
Secondary outcomes:
Other outcomes:
Locations:
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
Study officials:
affiliation: Medical University of South Carolina
name: Austin Hahn, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06280014: Evaluation of the Effects of Mefenamic Acid and Dexketoprofen on Postoperative Wisdom Dental Surgery
Official title: Evaluation of the Effects of Mefenamic Acid and Dexketoprofen on Postoperative Pain, Edema and Trismus in Impacted Wisdom Dental Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tooth, Impacted
Tooth Diseases
Keywords: impacted wisdom teeth
dexketoprofen
mefenamic acid
Lead sponsor: Yuzuncu Yıl University
Sponsor class: OTHER
First posted: 2024-02-28
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study was administered to 22 female and 8 male patients. Patients with impacted wisdom teeth on both sides of the mandible were selected. After impacted tooth extraction, the patient used mefenamic acid on one side and dexketoprofen on the other side for postoperative pain relief. The effects of these two materials on patient comfort were investigated.

Detailed description: The aim of this study; to compare the effects of dexketoprofen and mefanamic acid on pain, edema and trismus after lower impacted wisdom teeth surgery. 60 impacted wisdom teeth in 30 healthy individuals who applied to Van Yüzüncü Yıl University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery with an indication for extraction of impacted lower wisdom teeth were included in the study. 60 impacted wisdom teeth belonging to individuals were randomly divided into two groups (A and B). In a randomized, controlled, double-blind study, dexketoprofen (A) and mefanamic acid (B) were given to patients immediately after surgery. VAS (Visual Analog Scale) was used for pain assessment and assessment was made at 3, 6, 12 and 24 hours and 2, 3, 4, 5, 6 and 7 days. For the evaluation of edema, the facial measurements of the patients before the operation were recorded and repeated on the 2nd and 7th postoperative days. Preoperative maximum mouth opening measurement for trismus assessment was repeated on the 2nd and 7th postoperative days and recorded.

Eligibility criteria: Inclusion Criteria:

* Volunteers with bilateral fully impacted mandibular wisdom teeth

Exclusion Criteria:

* Patients were excluded from the study if they did not understand the clinical procedures of the study,
* Had allergies or intolerance to any of the substances used in the study,
* Patients on anticoagulant or psychiatric treatment,
* Pregnant or breastfeeding,
* Patients using oral contraceptiveswere,
* Diabetic,
* Patients with periodontal disease or active infection,
* Poor oral hygiene

Primary outcomes:
measure: Mouth opening measurements
timeFrame: 0-28 days
measure: Facial edema
timeFrame: 0-28 days
measure: Visual Analog Scale
timeFrame: 0-28 days
Secondary outcomes:
Other outcomes:
Locations:
city: Van
country: Turkey
facility: Serap Keskin Tunc
Study officials:
References:
Clinical trial NCT00029614: Atomoxetine to Treat Adolescents With Coexisting Alcohol and Other Substance Use Disorder and ADHD
Official title: Psychopharmacology of Adolescents With AUD and ADHD
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Substance Use Disorders
Attention Deficit Hyperactivity Disorder
Keywords: ADHD
Substance Use
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
Collaborators: name: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
First posted: 2002-01-17
Enrollment: 24
Sex: ALL
Minimum age (years): 13
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the effectiveness and safety of atomoxetine in the treatment of adolescents with coexisting alcohol or substance use disorders and Attention Deficit Hyperactivity Disorder (ADHD).


Eligibility criteria: Inclusion Criteria:

* Adolescents, ages 13-18
* Meets criteria for alcohol and/or substance use disorder and attention deficit hyperactivity disorder.

Exclusion Criteria:

* Adolescents who are pregnant.
* Have a history of seizure disorder, other neurological or medical disorder for which medication treatment may present a considerable risk.
* History of pervasive development disorder, schizophrenia or other psychotic disorders, organic mental disorders or eating disorders.
* Currently on other psychotropic medications from which discontinuation would present a significant risk.
* A current episode of major depressive disorder or a diagnosis of bipolar disorder.
* Diagnosis of dependence for any substance other than marijuana.
* Adolescents with a full-scale IQ below 80.

Primary outcomes:
measure: decrease in ADHD symptoms
measure: decrease in the quantity and frequency of alcohol and other substance use
Secondary outcomes:
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: Western Psychiatric Institute and Clinic
state: Pennsylvania
Study officials:
affiliation: Western Psychiatric Institute and Clinic
name: Oscar G. Bukstein, MD
role: PRINCIPAL_INVESTIGATOR
References: