Clinical trial NCT03047395: A Study to Assess the Safety and Efficacy of Risankizumab for Maintenance in Moderate to Severe Plaque Type Psoriasis ( LIMMITLESS )
Official title: A Multicenter, Open Label Study to Assess the Safety and Efficacy of Risankizumab for Maintenance in Moderate to Severe Plaque Type Psoriasis (LIMMITLESS)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Psoriasis
Keywords: ABBV-066
BI 655066
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2017-02-09
Enrollment: 2170
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate the long-term safety and efficacy of risankizumab in the treatment of moderate to severe chronic plaque psoriasis.

Detailed description: This is a Phase 3, single-arm, multicenter open label extension (OLE) study designed to investigate the long-term safety and efficacy of 150 mg risankizumab in the treatment of moderate to severe chronic plaque psoriasis. Approximately 2200 participants who meet the entry criteria are planned to be enrolled in this study, rolling over from the preceding Phase 2/3 studies.

Eligibility criteria: Inclusion Criteria:

* Participants with a history of moderate to severe chronic plaque psoriasis, who have completed one of the preceding studies.
* Participants must be candidates for prolonged open label risankizumab treatment according to investigator judgment.
* Females of childbearing potential must have a negative urine pregnancy test result at Baseline.

If female, participant must be either postmenopausal, OR permanently surgically sterile OR for women of childbearing potential practicing at least one protocol specified method of birth control, starting at Baseline through at least 20 weeks after the last dose of study drug.

- Participants must have signed and dated a written informed consent in accordance with Good Clinical Practice (GCP) and local legislation prior to admission into the study.

Exclusion Criteria:

* Premature discontinuation for any reason in the preceding study.
* Participants who have developed guttate, erythrodermic, pustular or drug-induced psoriasis as diagnosed by the investigator during the preceding study.
* Use of any prohibited medication or any drug considered likely to interfere with the safe conduct of the study, as assessed by the investigator.
* Evidence of a current or previous disease, medical condition (including chronic alcohol or drug abuse) other than psoriasis, surgical procedure (i.e., organ transplant), medical examination finding (including vital signs and ECG), or laboratory value outside the reference range that in the opinion of the investigator is clinically significant and would make the study participant unreliable to adhere to the protocol or to complete the study, compromise the safety of the subject, or compromise the quality of the data.
* Previous enrollment in this study.
* Female subject who is pregnant, breastfeeding or is considering becoming pregnant during the study or within 20 weeks after the last dose of study drug.
* Time elapsed is \> 8 weeks since the completion visit in the preceding study.
* Participant is considered by the investigator for any reason, to be an unsuitable candidate for the study and not able to comply with the study protocol.

Primary outcomes:
measure: Number of Participants With Serious Adverse Events and Non-Serious Adverse Events
timeFrame: Median follow-up time of 1905 days
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Total Skin and Beauty Dermatology Center /ID# 154000
state: Alabama
city: Birmingham
country: United States
facility: University of Alabama at Birmingham - Main /ID# 153983
state: Alabama
city: Rogers
country: United States
facility: NW Arkansas Clinical Trials Center /ID# 154014
state: Arkansas
city: Bakersfield
country: United States
facility: Bakersfield Derma & Skin Cance /ID# 154008
state: California
city: Encinitas
country: United States
facility: California Dermatology and Research Institute /ID# 154007
state: California
city: Encino
country: United States
facility: T. Joseph Raoof, MD, Inc. /ID# 154078
state: California
city: Fremont
country: United States
facility: Center for Dermatology Clinical Research /ID# 154009
state: California
city: Los Angeles
country: United States
facility: Kaiser Permanente Los Angeles /ID# 154079
state: California
city: Los Angeles
country: United States
facility: Dermatology Research Associates /ID# 153977
state: California
city: Los Angeles
country: United States
facility: Wallace Medical Group /ID# 154025
state: California
city: Oceanside
country: United States
facility: Dermatology Specialists, Inc /ID# 153984
state: California
city: Pasadena
country: United States
facility: Huntington Medical Foundation /ID# 154002
state: California
city: San Diego
country: United States
facility: Medderm Associates /ID# 154098
state: California
city: Santa Ana
country: United States
facility: Southern California Dermatology /ID# 154006
state: California
city: Sherman Oaks
country: United States
facility: UNISON Center for Clinical Tri /ID# 153979
state: California
city: Bridgeport
country: United States
facility: New England Research Associates, LLC /ID# 154004
state: Connecticut
city: Farmington
country: United States
facility: UConn Health /ID# 154128
state: Connecticut
city: Coral Gables
country: United States
facility: Florida Academic Centers Research /ID# 154045
state: Florida
city: Ormond Beach
country: United States
facility: Leavitt Medical Associates of Florida /ID# 154046
state: Florida
city: Port Orange
country: United States
facility: Progressive Medical Research /ID# 154027
state: Florida
city: Alpharetta
country: United States
facility: Hamilton Research, LLC /ID# 153980
state: Georgia
city: Sandy Springs
country: United States
facility: Advanced Medical Research, PC /ID# 153999
state: Georgia
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine /ID# 153974
state: Illinois
city: Chicago
country: United States
facility: Rush University Medical Center /ID# 154099
state: Illinois
city: Rolling Meadows
country: United States
facility: Arlington Dermatology /ID# 153975
state: Illinois
city: Skokie
country: United States
facility: Northshore University Health System Dermatology Clinical Trials Unit /ID# 154011
state: Illinois
city: West Dundee
country: United States
facility: Dundee Dermatology /ID# 154110
state: Illinois
city: Indianapolis
country: United States
facility: Dawes Fretzin, LLC /ID# 154146
state: Indiana
city: New Albany
country: United States
facility: The Dermatology Center PSC - New Albany /ID# 154075
state: Indiana
city: Plainfield
country: United States
facility: The Indiana Clinical Trials Center /ID# 153976
state: Indiana
city: South Bend
country: United States
facility: The South Bend Clinic Center /ID# 154147
state: Indiana
city: Overland Park
country: United States
facility: Epiphany Dermatology of Kansas LLC /ID# 153993
state: Kansas
city: Louisville
country: United States
facility: Skin Sciences, PLLC /ID# 153991
state: Kentucky
city: Louisville
country: United States
facility: DS Research /ID# 154028
state: Kentucky
city: Boston
country: United States
facility: Massachusetts General Hospital /ID# 153990
state: Massachusetts
city: Methuen
country: United States
facility: ActivMed Practices and Research, LLC. /ID# 154044
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 154111
state: Michigan
city: Bay City
country: United States
facility: Great Lakes Research Group - Bay City /ID# 153998
state: Michigan
city: Clinton Township
country: United States
facility: Michigan Center for Skin Care Research /ID# 153986
state: Michigan
city: Troy
country: United States
facility: Somerset Skin Centre /ID# 154097
state: Michigan
city: New Brighton
country: United States
facility: Minnesota Clinical Study Center /ID# 154015
state: Minnesota
city: Saint Louis
country: United States
facility: Central Dermatology, PC /ID# 154013
state: Missouri
city: Omaha
country: United States
facility: Skin Specialists, PC /ID# 154024
state: Nebraska
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center /ID# 154095
state: New Hampshire
city: East Windsor
country: United States
facility: Psoriasis Treatment Center of Central New Jersey /ID# 154001
state: New Jersey
city: Verona
country: United States
facility: Schweiger Dermatology Group /ID# 202489
state: New Jersey
city: Kew Gardens
country: United States
facility: Forest Hills Dermatology Group /ID# 154113
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai /ID# 154129
state: New York
city: New York
country: United States
facility: The Rockefeller University /ID# 153994
state: New York
city: Stony Brook
country: United States
facility: DermResearchCenter of New York, Inc. /ID# 154012
state: New York
city: Williamsville
country: United States
facility: Buffalo Medical Group /ID# 154148
state: New York
city: Charlotte
country: United States
facility: Darst Dermatology /ID# 154076
state: North Carolina
city: High Point
country: United States
facility: Dermatology Consulting Service /ID# 154010
state: North Carolina
city: Raleigh
country: United States
facility: Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 202490
state: North Carolina
city: Wilmington
country: United States
facility: Wilmington Dermatology Center /ID# 154109
state: North Carolina
city: Cincinnati
country: United States
facility: Synexus Research Cincinnati /ID# 153997
state: Ohio
city: Portland
country: United States
facility: Oregon Dermatology and Research Center /ID# 153982
state: Oregon
city: Portland
country: United States
facility: Oregon Medical Research Center /ID# 154003
state: Oregon
city: Duncansville
country: United States
facility: Altoona Ctr Clinical Res /ID# 153981
state: Pennsylvania
city: Philadelphia
country: United States
facility: Paddington Testing Co., Inc. /ID# 154022
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh MC /ID# 153995
state: Pennsylvania
city: Johnston
country: United States
facility: Clinical Partners, LLC /ID# 154096
state: Rhode Island
city: Charleston
country: United States
facility: Coastal Clinical Research Center of the Carolinas /ID# 154112
state: South Carolina
city: Greer
country: United States
facility: Synexus Clinical Research US, Inc. /ID# 154127
state: South Carolina
city: North Charleston
country: United States
facility: Coastal Carolina Research Center /ID# 153992
state: South Carolina
city: Rapid City
country: United States
facility: Health Concepts /ID# 153996
state: South Dakota
city: Austin
country: United States
facility: Austin Dermatology Associates /ID# 154042
state: Texas
city: Bellaire
country: United States
facility: Bellaire Dermatology Associates /ID# 153987
state: Texas
city: Dallas
country: United States
facility: Modern Research Associates, PLLC /ID# 154043
state: Texas
city: Dallas
country: United States
facility: Menter Dermatology Res Inst /ID# 153985
state: Texas
city: Houston
country: United States
facility: Center for Clinical Studies - Houston (Binz) /ID# 154005
state: Texas
city: Houston
country: United States
facility: Suzanne Bruce and Associates-Houston /ID# 154026
state: Texas
city: San Antonio
country: United States
facility: Derm Clin Res Ctr San Antonio /ID# 153978
state: Texas
city: San Antonio
country: United States
facility: Progressive Clinical Research /ID# 154149
state: Texas
city: San Antonio
country: United States
facility: Dermatology San Antonio /ID# 154077
state: Texas
city: Webster
country: United States
facility: Center for Clinical Studies Webster TX /ID# 154150
state: Texas
city: Norfolk
country: United States
facility: Virginia Clinical Research, Inc. /ID# 154016
state: Virginia
city: Seattle
country: United States
facility: Dermatology Associates of Seattle /ID# 153988
state: Washington
city: Spokane
country: United States
facility: Premier Clinical Research /ID# 154284
state: Washington
city: Phillip
country: Australia
facility: Paratus Clinical Research Woden /ID# 154307
state: Australian Capital Territory
city: Kogarah
country: Australia
facility: St George Dermatology & Skin Cancer Centre /ID# 154308
state: New South Wales
city: Woolloongabba
country: Australia
facility: Specialist Connect Pty Ltd /ID# 154311
state: Queensland
city: Campbelltown
country: Australia
facility: North Eastern Health Specialists /ID# 154309
state: South Australia
city: Carlton
country: Australia
facility: Skin Health Institute Inc /ID# 154305
state: Victoria
city: Melbourne
country: Australia
facility: Sinclair Dermatology - Melbourne /ID# 154310
state: Victoria
city: Fremantle
country: Australia
facility: Fremantle Dermatology /ID# 154306
state: Western Australia
city: Feldkirch
country: Austria
facility: Landeskrankenhaus Feldkirch /ID# 154303
state: Vorarlberg
city: Vienna
country: Austria
facility: Klinik Landstrasse /ID# 154300
state: Wien
city: Vienna
country: Austria
facility: Medizinische Universitaet Wien /ID# 154302
state: Wien
city: Brussels
country: Belgium
facility: Cliniques Universitaires de Bruxelles Hopital Erasme /ID# 154293
state: Bruxelles-Capitale
city: Jette
country: Belgium
facility: Universitair Ziekenhuis Brussel /ID# 154295
state: Bruxelles-Capitale
city: Woluwe-Saint-Lambert
country: Belgium
facility: Cliniques Universitaires UCL Saint-Luc /ID# 154294
state: Bruxelles-Capitale
city: Liège
country: Belgium
facility: CHU de Liege Sart Tilman /ID# 154297
state: Liege
city: Gent
country: Belgium
facility: UZ Gent /ID# 154296
state: Oost-Vlaanderen
city: Loverval
country: Belgium
facility: IMTR - Grand Hopital de Charleroi /ID# 154298
city: Calgary
country: Canada
facility: Kirk Barber Research, CA /ID# 153840
state: Alberta
city: Calgary
country: Canada
facility: Dermatology Research Institute Inc. /ID# 153850
state: Alberta
city: Edmonton
country: Canada
facility: Stratica Medical /ID# 153848
state: Alberta
city: Surrey
country: Canada
facility: Dr. Chih-ho Hong Medical Inc. /ID# 153842
state: British Columbia
city: Surrey
country: Canada
facility: Enverus Medical Research /ID# 153851
state: British Columbia
city: St. John's
country: Canada
facility: Karma Clinical Trials /ID# 153876
state: Newfoundland and Labrador
city: Halifax
country: Canada
facility: Eastern Canada Cutaneous Resea /ID# 153870
state: Nova Scotia
city: Ajax
country: Canada
facility: CCA Medical Research /ID# 153859
state: Ontario
city: Etobicoke
country: Canada
facility: Kingsway Clinical Research /ID# 154292
state: Ontario
city: Hamilton
country: Canada
facility: Dermatrials Research /ID# 153847
state: Ontario
city: London
country: Canada
facility: The Guenther Dermatology Research Centre /ID# 153841
state: Ontario
city: Markham
country: Canada
facility: Lynderm Research Inc. /ID# 153861
state: Ontario
city: Mississauga
country: Canada
facility: DermEdge Research Inc. /ID# 153843
state: Ontario
city: North Bay
country: Canada
facility: North Bay Dermatology Centre /ID# 153845
state: Ontario
city: Oakville
country: Canada
facility: The Centre for Clinical Trials /ID# 153871
state: Ontario
city: Ottawa
country: Canada
facility: Dermatology Ottawa Research Centre /ID# 153862
state: Ontario
city: Peterborough
country: Canada
facility: SKiN Centre for Dermatology /ID# 153853
state: Ontario
city: Richmond Hill
country: Canada
facility: The Center For Dermatology /ID# 153844
state: Ontario
city: Richmond Hill
country: Canada
facility: York Dermatology Clinic and Research Centre /ID# 153860
state: Ontario
city: Toronto
country: Canada
facility: Toronto Research Centre /ID# 153852
state: Ontario
city: Toronto
country: Canada
facility: Research Toronto /ID# 153854
state: Ontario
city: Waterloo
country: Canada
facility: K. Papp Clinical Research /ID# 153855
state: Ontario
city: Windsor
country: Canada
facility: XLR8 Medical Research /ID# 153858
state: Ontario
city: Windsor
country: Canada
facility: Windsor Clinical Research, Inc /ID# 153877
state: Ontario
city: Montréal
country: Canada
facility: Innovaderm Research Inc. /ID# 153846
state: Quebec
city: Québec
country: Canada
facility: Centre de Recherche dermatologique du Quebec Metropolitain /ID# 153856
state: Quebec
city: Cerveny Kostelec
country: Czechia
facility: DERMAMEDICA, s.r.o. /ID# 153890
city: Ostrava
country: Czechia
facility: Medical research s.r.o. /ID# 153898
city: Prague 10
country: Czechia
facility: Clintrial s.r.o. /ID# 153889
city: Prague 4
country: Czechia
facility: CCR Czech a.s /ID# 153887
city: Prague
country: Czechia
facility: Pratia Prague s.r.o. /ID# 153897
city: Praha
country: Czechia
facility: MUDr. Blanka Havlickova - dermatovenerologie /ID# 153888
city: Tampere
country: Finland
facility: Terveystalo Tampere /ID# 154118
city: Turku
country: Finland
facility: Mehilainen Turku /ID# 154120
city: Nice
country: France
facility: Chu de Nice-Hopital Larchet Ii /Id# 153948
state: Alpes-Maritimes
city: Rouen
country: France
facility: Hôpital Charles-Nicolle /ID# 205842
city: Toulouse
country: France
facility: CHU Toulouse - Hopital Larrey /ID# 153951
city: Heidelberg
country: Germany
facility: Universitaetsklinik Heidelberg /ID# 153910
state: Baden-Wuerttemberg
city: Tubingen
country: Germany
facility: Universitaetsklinikum Tuebingen /ID# 153912
state: Baden-Wuerttemberg
city: Erlangen
country: Germany
facility: Universitaetsklinikum Erlangen /ID# 154093
state: Bayern
city: Blankenfelde-Mahlow
country: Germany
facility: Dermatologische Gemeinschaftspraxis Mahlow /ID# 153892
state: Brandenburg
city: Darmstadt
country: Germany
facility: Klinikum Darmstadt GmbH /ID# 153893
state: Hessen
city: Frankfurt am Main
country: Germany
facility: Universitaetsklinikum Frankfurt /ID# 153891
state: Hessen
city: Munster
country: Germany
facility: Universitaetsklinikum Muenster /ID# 153895
state: Niedersachsen
city: Mainz
country: Germany
facility: Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz /ID# 154092
state: Rheinland-Pfalz
city: Selters
country: Germany
facility: CMS3 Company for Medical Study /ID# 201318
state: Rheinland-Pfalz
city: Leipzig
country: Germany
facility: Universitaetsklinikum Leipzig /ID# 153909
state: Sachsen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 153916
state: Schleswig-Holstein
city: Kiel
country: Germany
facility: DermaKiel Allergie und Haut Centrum /ID# 201316
state: Schleswig-Holstein
city: Berlin
country: Germany
facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 153896
city: Berlin
country: Germany
facility: ISA Interdisciplinary Study Association GmbH /ID# 153907
city: Bochum
country: Germany
facility: Hautarztpraxis Dr. Niesmann und Dr. Othlinghaus /ID# 154289
city: Bonn
country: Germany
facility: Universitaetsklinikum Bonn /ID# 154094
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 153906
city: Goettingen
country: Germany
facility: Universitaetsmedizin Goettingen /ID# 154091
city: Hamburg
country: Germany
facility: Universitaetsklinikum Hamburg-Eppendorf /ID# 154089
city: Hamburg
country: Germany
facility: Klinische Forschung Hamburg GmbH /ID# 154290
city: Hamburg
country: Germany
facility: TFS Trial Form Support GmbH /ID# 153894
city: Munich
country: Germany
facility: Klinikum rechts der Isar - Technische Universitaet Muenchen /ID# 153915
city: Schwerin
country: Germany
facility: Klinische Forschung Schwerin GmbH /ID# 154291
city: Witten
country: Germany
facility: Hautarztpraxis Dr. med. Matthias Hoffmann /ID# 153917
city: Wuppertal
country: Germany
facility: CentroDerm GmbH /ID# 153914
city: Nagoya shi
country: Japan
facility: Nagoya City University Hospital /ID# 153866
state: Aichi
city: Fukuoka-shi
country: Japan
facility: Fukuoka University Hospital /ID# 153864
state: Fukuoka
city: Kurume-shi
country: Japan
facility: Kurume University Hospital /ID# 156320
state: Fukuoka
city: Fukushima-shi
country: Japan
facility: Fukushima Medical University Hospital /ID# 153873
state: Fukushima
city: Gifu-shi
country: Japan
facility: Gifu University Hospital /ID# 169410
state: Gifu
city: Sapporo-shi
country: Japan
facility: JR Sapporo Hospital /ID# 201963
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Medical Corporation Kojinkai Sapporo Skin Clinic /ID# 154083
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Hokkaido University Hospital /ID# 154285
state: Hokkaido
city: Kobe-shi
country: Japan
facility: Kobe University Hospital /ID# 170706
state: Hyogo
city: Shiwa-gun
country: Japan
facility: Iwate Medical University Hospital /ID# 170843
state: Iwate
city: Kita-gun
country: Japan
facility: Kagawa University Hospital /ID# 168656
state: Kagawa
city: Kawasaki-shi
country: Japan
facility: Japan Organization of Occupational Health and Society Kanto Rosai Hospital /ID# 169172
state: Kanagawa
city: Sagamihara-shi
country: Japan
facility: National Hospital Organization Sagamihara National Hospital /ID# 153867
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Yokohama City University Hospital /ID# 168831
state: Kanagawa
city: Kyoto-shi
country: Japan
facility: University Hospital Kyoto Prefectural University of Medicine /ID# 169415
state: Kyoto
city: Kyoto-shi
country: Japan
facility: Kyoto University Hospital /ID# 156318
state: Kyoto
city: Tsu-shi
country: Japan
facility: Mie University Hospital /ID# 156317
state: Mie
city: Sendai-shi
country: Japan
facility: Tohoku University Hospital /ID# 169006
state: Miyagi
city: Matsumoto-shi
country: Japan
facility: Shinshu University Hospital /ID# 170937
state: Nagano
city: Nagasaki-shi
country: Japan
facility: Nagasaki University Hospital /ID# 170219
state: Nagasaki
city: Okayama-shi
country: Japan
facility: Okayama University Hospital /ID# 200631
state: Okayama
city: Hirakata-shi
country: Japan
facility: Kansai Medical University Hospital /ID# 170884
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka Metropolitan University Hospital /ID# 153869
state: Osaka
city: Osaka-shi
country: Japan
facility: Nippon Life Saiseikai Public Interest Foundation Nippon Life Hospital /ID# 156319
state: Osaka
city: Osakasayama-shi
country: Japan
facility: Kindai University Hospital /ID# 153865
state: Osaka
city: Suita-shi
country: Japan
facility: Osaka University Hospital /ID# 156321
state: Osaka
city: Hamamatsu-shi
country: Japan
facility: Hamamatsu University Hospital /ID# 170132
state: Shizuoka
city: Shimotsuke-shi
country: Japan
facility: Jichi Medical University Hospital /ID# 154286
state: Tochigi
city: Bunkyo-ku
country: Japan
facility: Juntendo University Hospital /ID# 200292
state: Tokyo
city: Bunkyo-ku
country: Japan
facility: Nippon Medical School Hospital /ID# 154084
state: Tokyo
city: Chiyoda-ku
country: Japan
facility: Tokyo Teishin Hospital /ID# 165912
state: Tokyo
city: Chuo-ku
country: Japan
facility: St.Luke's International Hospital /ID# 153863
state: Tokyo
city: Itabashi-ku
country: Japan
facility: Teikyo University Hospital /ID# 154287
state: Tokyo
city: Itabashi-ku
country: Japan
facility: Nihon University Itabashi Hospital /ID# 154081
state: Tokyo
city: Minato-ku
country: Japan
facility: The Jikei University Hospital /ID# 154080
state: Tokyo
city: Shinagawa-ku
country: Japan
facility: NTT Medical Center Tokyo /ID# 154082
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Medical University Hospital /ID# 153874
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Japan Community Health care Organization Tokyo Yamate Medical Center /ID# 153868
state: Tokyo
city: Ube-shi
country: Japan
facility: Yamaguchi University Hospital /ID# 156322
state: Yamaguchi
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center /ID# 153489
state: Gyeonggido
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital /ID# 153491
state: Gyeonggido
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital /ID# 153488
state: Jeonranamdo
city: Seoul
country: Korea, Republic of
facility: KonKuk University Medical Center /ID# 153483
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Korea Universtiy Guro Hospital /ID# 153490
state: Seoul Teugbyeolsi
city: 서초구
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St. Mary's Hospital /ID# 153486
state: Seoul Teugbyeolsi
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital /ID# 153485
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital /ID# 153484
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center /ID# 153487
city: Monterrey
country: Mexico
facility: Hospital Universitario Dr. Jose Eleuterio Gonzalez /ID# 153882
state: Nuevo Leon
city: Aguascalientes
country: Mexico
facility: Derma Norte del Bajio S.C. /ID# 153880
city: Monterrey
country: Mexico
facility: Centro de Dermatologia de Monterrey /ID# 153881
city: Wroclaw
country: Poland
facility: Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocawiu /ID# 153473
state: Dolnoslaskie
city: Lodz
country: Poland
facility: Dermoklinika Medical Center /ID# 153470
state: Lodzkie
city: Lublin
country: Poland
facility: KO-MED Centra Kliniczne Lublin /ID# 153469
state: Lubelskie
city: Krakow
country: Poland
facility: Pratia MCM Krakow /ID# 153472
state: Malopolskie
city: Warszawa
country: Poland
facility: High-Med Przychodnia Specjalistyczna /ID# 153468
state: Mazowieckie
city: Warszawa
country: Poland
facility: Klinika Ambroziak Sp. z o.o. /ID# 153467
state: Mazowieckie
city: Bialystok
country: Poland
facility: Osteo-Medic S.C. /ID# 156535
state: Podlaskie
city: Gdansk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne /ID# 153471
state: Pomorskie
city: Gdansk
country: Poland
facility: Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 153884
state: Pomorskie
city: Poznan
country: Poland
facility: Solumed Centrum Medyczne /ID# 153466
state: Wielkopolskie
city: Braga
country: Portugal
facility: 2CA-Braga, Hospital de Braga /ID# 156323
city: Lisboa
country: Portugal
facility: Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 153462
city: Porto
country: Portugal
facility: CHP, EPE- Hospital Geral de Sa /ID# 153464
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 153463
city: Badalona
country: Spain
facility: Hospital Universitario Germans Trias i Pujol /ID# 153465
state: Barcelona
city: Barcelona
country: Spain
facility: Hospital Santa Creu i Sant Pau /ID# 154125
city: Madrid
country: Spain
facility: Hospital Universitario Infanta Leonor /ID# 154121
city: Valencia
country: Spain
facility: Hospital General Universitario de Valencia /ID# 154126
city: Solna
country: Sweden
facility: Karolinska University Hospital Solna /ID# 154131
state: Stockholms Lan
city: Gothenburg
country: Sweden
facility: Sahlgrenska University Hospital /ID# 154132
state: Vastra Gotalands Lan
city: Stockholm
country: Sweden
facility: Sodersjukhuset /ID# 154130
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 154136
state: Taipei
city: New Taipei City
country: Taiwan
facility: Taipei Medical University Shuang Ho Hospital /ID# 154134
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital /ID# 154135
city: Taipei
country: Taiwan
facility: Taiwan Adventist Hospital /ID# 154137
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References:
citation: Papp KA, Lebwohl MG, Puig L, Ohtsuki M, Beissert S, Zeng J, Rubant S, Sinvhal R, Zhao Y, Soliman AM, Alperovich G, Leonardi C. Long-term efficacy and safety of risankizumab for the treatment of moderate-to-severe plaque psoriasis: interim analysis of the LIMMitless open-label extension trial beyond 3 years of follow-up. Br J Dermatol. 2021 Dec;185(6):1135-1145. doi: 10.1111/bjd.20595. Epub 2021 Sep 21.