Clinical trial NCT02480738: Effectiveness of Computerized Cognitive Training in the Elderly With Cognitive Impairment
Official title: Effectiveness of Computerized Cognitive Training Apparatus (CoCoTA) in the Elderly With Normal Cognition, Subjective Cognitive Impairment, Mild Cognitive Impairment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mild Cognitive Impairment
Keywords: subjective cognitive impairment
Lead sponsor: Seoul National University Bundang Hospital
Sponsor class: OTHER
First posted: 2015-06-24
Enrollment: 26
Sex: ALL
Minimum age (years): 51
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is to investigate the effectiveness of computerized cognitive training, and corresponding neural substrates through multimodal neuroimaging assessment, in the elderly with normal cognition, subjective cognitive impairment, and mild cognitive impairment.

Detailed description: Computerized cognitive training has the advantage of easy accessibility for community-dwelling elderly. It can be much cheaper than traditional neuropsychological training methods, which require trained neuropsychologists. Furthermore, it may be more fun and easier to be optimized to an individual patients' cognitive status than other traditional methods.

Clinical efficacy of these kinds of cognitive training applications has been validated through several studies. A recent systematic review reported that the domains of working memory, executive function, and processing speed benefited the most by classic computerized cognitive training tasks, and that these benefits were comparable with traditional cognitive training methods. Apart from neuropsychological data, neuroimaging studies focusing on the effectiveness of computerized cognitive training are scant.

There have been no previous studies investigating the possible neural substrates of computerized cognitive training using multimodal neuroimaging modalities simultaneously. Thus, we aimed to investigate the effectiveness of computerized cognitive training and corresponding neural substrates in subjects with mild cognitive impairment, subjective memory impairment, and normal controls through a multimodal approach.

Eligibility criteria: Inclusion Criteria:

* Ages \>50 to ≤70
* Years of education ≥ 6 years
* No physical barrier preventing the dominant hand from using the computer mouse

Exclusion Criteria:

* Subjects who had any structural lesions or psychiatric disorders that explained the memory deficits
* Subjects had to be able to undergo pre- and post-training evaluations such as electroencephalography (EEG), FDG-PET, and magnetic resonance imaging (MRI)
* Subjects who had scalp lesions, severe back pain, or claustrophobia that precluded pre- and post-training evaluations.

Primary outcomes:
measure: Clinical improvement in the follow-up neuropsychological tests
timeFrame: 12 weeks
Secondary outcomes:
measure: Cortical thickness changes between baseline and follow-up volumetric MRI
timeFrame: 12 weeks
measure: White matter integrities changes between baseline and follow-up diffusion tensor imaging
timeFrame: 12 weeks
measure: Spectral ratio changes between baseline and follow-up EEG
timeFrame: 12 weeks
measure: local activation pattern changes between baseline and follow-up Fludeoxyglucose PET
timeFrame: 12 weeks
Other outcomes:
Locations:
Study officials:
affiliation: Seoul National University Bundang Hospital
name: SangYun Kim, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Na HR, Lim JS, Kim WJ, Jang JW, Baek MJ, Kim J, Park YH, Park SY, Kim S. Multimodal Assessment of Neural Substrates in Computerized Cognitive Training: A Preliminary Study. J Clin Neurol. 2018 Oct;14(4):454-463. doi: 10.3988/jcn.2018.14.4.454. Epub 2018 Jun 26.