Clinical trial NCT03761576: The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery
Official title: The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Pain
Chronic Pain
Thoracic Surgery
Electroencephalography
Brain Mechanism
Lead sponsor: Peking University People's Hospital
Sponsor class: OTHER
First posted: 2018-12-03
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 100

Brief summary: The project will apply the methods of clinical observation experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after surgery. (2) to collect the resting-state electroencephalography (EEG) preoperatively, and to assess the role of EEG index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after surgery.

Detailed description: Patients after surgery are liable to suffer from moderate to severe acute pain and refractory chronic pain, which would lead to serious somatic and psychological suffering. Its successful treatment is a great challenge for pain physicians. To date, the mechanism of pain chronification after surgery remains unclear. Further, it is still lack of efficient preventive and therapeutic measures for this chronic pain. The project will apply the methods of clinical observation and animal experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after thoracic surgery. (2) to collect the resting-state electroencephalography (EEG) preoperatively, and to assess the role of EEG index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after thoracic surgery. The project will be able to determine the relationships between the degree of recovery of early postoperative cognitive function, as well as preoperative resting-state EEG indices and postoperative acute pain and chronic pain, and clarify the neural mechanism of acute pain and chronic pain after surgery. The expected outcomes of this study can contribute to early identification of the patients who are liable to develop into acute pain and chronic pain after surgery, and give them reasonable intervention in time, and provide effective solutions for the acute pain and chronic pain after surgery.

Eligibility criteria: Inclusion Criteria:

* surgery were planned to be performed under general anesthesia
* Educational attainment beyond high school
* Require postoperative analgesia and sign the informed consent

Exclusion Criteria:

* with mental illness or a family history of mental illness
* Patients with cerebrovascular diseases or cerebrovascular accidents
* Previous head trauma history or craniotomy
* Using central analgesics, opioids addiction
* With a history of alcoholism
* do not understand the numerical rating scale(NRS) score and can not use patient-controlled analgesia(PCA）

Primary outcomes:
measure: acute pain
timeFrame: the third day of the surgery
measure: chronic pain
timeFrame: the second month of the surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University People's Hospital
state: Beijing
Study officials:
affiliation: Peking University People's Hospital
name: Yi Feng, MD
role: STUDY_CHAIR
References:
citation: Han Q, Yue L, Gao F, Zhang L, Hu L, Feng Y. The Prediction of Acute Postoperative Pain Based on Neural Oscillations Measured before the Surgery. Neural Plast. 2021 Apr 9;2021:5543974. doi: 10.1155/2021/5543974. eCollection 2021.