louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04256382: Dementia Pain Management Educational Program
Official title: Dementia Pain Management Knowledge Scale Development and Impact of an Educational Program on Hospital Nurses' Knowledge Evaluation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dementia
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
First posted: 2020-02-05
Enrollment: 285
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study aims to develop and test a scale for exploring hospital nurses' knowledge about dementia pain and dementia pain management.

Detailed description: The researcher recruited 285 nurses from three hospitals, and divided them into the experimental group and the comparison group. The experimental group took two-hour online course about dementia pain care in two weeks. The comparison group took two-hour online course about dementia care in two weeks. The nurses performed a post-test after the two-week course immediately; two weeks later, the second post-test was performed again.

Eligibility criteria: Inclusion Criteria:

* Nurses working in district hospitals, regional hospitals, or medical centers.

Exclusion Criteria:

* Nurses working with obstetrics, pediatrics, or outpatient.

Primary outcomes:
measure: score of Dementia Pain Management Knowledge Scale
timeFrame: 2 months
Secondary outcomes:
measure: score of Dementia Care Knowledge 16
timeFrame: 2 months
measure: score of the Chinese version of the Knowledge and Beliefs About Pain in Elderly Patients With Dementia (KBPED-C) questionnaire
timeFrame: 2 months
Other outcomes:
Locations:
city: Kaohsiung city
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
Study officials:
References:
Clinical trial NCT06063382: Extra Time on Brazilian College Level Exam for Students With and Without ADHD
Official title: Extended Time on Exams as an Accommodation at First Level of Higher Education: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Attention Deficit Disorder With Hyperactivity
Keywords: Extended time
Academic test Performance
Academic Achievement
Neuropsychological Testing
Cognitive Function
Lead sponsor: Hospital de Clinicas de Porto Alegre
Sponsor class: OTHER
First posted: 2023-10-02
Enrollment: 80
Sex: ALL
Minimum age (years): 16
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants will be assigned either to the "ADHD group" or "non-ADHD group" based on diagnosis. Both groups will receive the same intervention, which is to perform three academic exams based on the Brazilian National High School Exam (ENEM) under three different time conditions (40 minutes, 50 minutes and 60 minutes). The order in which they will perform each exam and with which time condition will be randomized.

In order to emulate real-life conditions in which students compete for college entry and motivate them, the participants will be competing for valuable prizes (ebook readers).
Primary purpose: OTHER

Brief summary: Standardized tests such as the Scholastic Aptitude Test (SAT) and the brazilian National High School Exam (ENEM) give more time for students with Attention Deficit and Hyperactivity Disorders (ADHD) to complete the exam. The goal of this study is to find out if giving students with ADHD more time on tests actually helps them. Additionally, the research aims to find out if more time helps students without ADHD too or not, or even if it only helps students with certain traits.

Detailed description: Initially, the participants of this study will fill out forms and questionnaires online. Then, they will go through a psychiatric evaluation, where they will talk to a psychiatrist, and neuropsychological testing, where they will do some mental activities. Later on, they will do a mock test of the ENEM, with and without extra time.

Eligibility criteria: Inclusion Criteria:

* Brazilian citizen;
* Planing to participate in college-entry standardized tests (ENEM, Vestibulares);

Exclusion Criteria:

* Medical condition and/or disability that may hinder the neuropsychological testing;
* Intelligence Quotient (IQ) lower than 80;
* Psychotic disorders, bipolar disorders, current moderate or severe depressive episode, suicide risk, autism spectrum disorders, learning disabilities.

Primary outcomes:
measure: Test performance
timeFrame: During Intervention
Secondary outcomes:
measure: Time spent
timeFrame: During Intervention
Other outcomes:
Locations:
city: Porto Alegre
country: Brazil
facility: Hospital de Clínicas de Porto Alegre
state: Rio Grande Do Sul
Study officials:
affiliation: Hospital de Clínicas de Porto Alegre
name: Luis Augusto Paim Rohde, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05460182: Treatment of Single Maxillary Gingival Recession With Loss of Inter-dental Attachment. A Randomized Controlled Clinical Trial
Official title: Coronally Advanced Flap With and Without Connective Tissue Graft for the Treatment of Single Maxillary Gingival Recession With Loss of Inter-dental Attachment. A Randomized Controlled Clinical Trial - 10 Years Results
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Gingival Recession
Lead sponsor: University of Florence
Sponsor class: OTHER
First posted: 2022-07-15
Enrollment: 29
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Background: The aim of this randomized clinical trial (RCT) was to evaluate the adjunctive benefit of Connective Tissue Graft (CTG) to Coronally Advanced Flap (CAF) for the treatment of gingival recession associated with inter-dental clinical attachment loss equal or smaller to the buccal attachment loss (RT2). Material and Methods:The patients were randomly assigned to CAF+CTG (test group) or to CAF alone (Control group). Measurements were performed by a blind and calibrated examiner. Outcome measures included complete root coverage (CRC), recession reduction (RecRed), Root coverage Esthetic Score (RES), intra-operative and post-operative morbidity, and root sensitivity.


Eligibility criteria: Inclusion Criteria:

* Smoking \< 20 cigarettes/day.
* Full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) \< 15% (measured at four sites per tooth).
* Presence of at least one RT2 (Cairo et al. 2011) buccal gingival recession \> 2 mm of depth
* Only gingival recessions localized at upper central and lateral incisors, canine, and first and second pre-molars associated with aesthetic problems and/ordental hypersensitivity were considered.
* Presence of an identifiable CEJ

Exclusion Criteria:

* Systemic diseases or pregnancy.
* Systemic antibiotic therapy in the last 6 months.
* Active periodontal disease with sites showing probing depth \>4 mm.

Primary outcomes:
measure: Complete Root Coverage (CRC)
timeFrame: After the intervention (10 years)
Secondary outcomes:
measure: Recession Reduction (RecRed)
timeFrame: After the intervention (10 years)
measure: Root Coverage Aesthetic Score (RES)
timeFrame: After the intervention (10 years)
Other outcomes:
Locations:
city: Florence
country: Italy
facility: University of Florence
state: Tuscany
Study officials:
References:
Clinical trial NCT03779282: KETODEX for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery
Official title: KETODEX for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Emergence Delirium
Strabismus
Lead sponsor: Ochsner Health System
Sponsor class: OTHER
First posted: 2018-12-19
Enrollment: 90
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy children, aged 0-18 years, undergoing outpatient strabismus surgery under general anesthesia

Brief summary: Strabismus surgery for children is a very common procedure, with a high incidence of emergence delerium in the recovery room. A combination of intravenous ketamine/dexmedetomidine, or ketodex, has been previously shown to reduce emergence delerium in children undergoing adenotonsillectomy. Here, we study its application in strabismus surgery.


Eligibility criteria: Inclusion Criteria:

* ASA I/II children undergoing outpatient strabismus surgery

Exclusion Criteria:

* anything not meeting the above

Primary outcomes:
measure: Pediatric Anesthesia Emergence Delirium scale scores
timeFrame: up to 6 hours in recovery room
Secondary outcomes:
measure: wong-baker or numeric pain scores, depending on age
timeFrame: up to 6 hours in recovery room
measure: discharge time
timeFrame: up to 24 hours
Other outcomes:
Locations:
city: Jefferson
country: United States
facility: Ochsner Main Campus
state: Louisiana
Study officials:
affiliation: Ochsner Health System
name: Khaled Dajani, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hadi SM, Saleh AJ, Tang YZ, Daoud A, Mei X, Ouyang W. The effect of KETODEX on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane based-anesthesia. Int J Pediatr Otorhinolaryngol. 2015 May;79(5):671-6. doi: 10.1016/j.ijporl.2015.02.012. Epub 2015 Feb 19.
Clinical trial NCT03400982: Reference Curve on Bone Mineral Density in Men
Official title: Reference Curve on Bone Mineral Density in Men
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bone Mineral Density
Grip Strength
Physical Performance
Lead sponsor: Centre Hospitalier Régional d'Orléans
Sponsor class: OTHER
First posted: 2018-01-17
Enrollment: 200
Sex: MALE
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: In men, the hope of lower life, the absence of equivalent of menopause and the existence of a higher peak bone mass are the three factors that explain the lower incidence of osteoporosis in men.


Eligibility criteria: Inclusion Criteria:

* Male
* Aged between 20 and 30 years
* Caucasians

Exclusion Criteria:

* Lack of express consent
* Pieces of metal or plastic parts in field
* Diseases which cause technical difficulties for the correct evaluation of the hip and spine (severe dysplasia, hip surgery or lumbar spine)
* Adult protect buy the law

Primary outcomes:
measure: Bone mineral density of the spine
timeFrame: Day 0
measure: Bone mineral density of the hip
timeFrame: Day 0
Secondary outcomes:
measure: Fat mass of the body
timeFrame: day 0
measure: Lean mass of the body
timeFrame: day 0
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens
city: Paris
country: France
facility: Hopital Lariboisiere
city: Saint-Étienne
country: France
facility: CHU de Saint Etienne
Study officials:
affiliation: CHR Orléans
name: Eric LESPESSAILLES
role: PRINCIPAL_INVESTIGATOR
References:
citation: Abrahamsen B, Hansen TB, Jensen LB, Hermann AP, Eiken P. Site of osteodensitometry in perimenopausal women: correlation and limits of agreement between anatomic regions. J Bone Miner Res. 1997 Sep;12(9):1471-9. doi: 10.1359/jbmr.1997.12.9.1471.
citation: Smotherman MS, Narins PM. Effect of temperature on electrical resonance in leopard frog saccular hair cells. J Neurophysiol. 1998 Jan;79(1):312-21. doi: 10.1152/jn.1998.79.1.312.
citation: Baumgartner RN. Body composition in elderly persons: a critical review of needs and methods. Prog Food Nutr Sci. 1993 Jul-Sep;17(3):223-60.
Clinical trial NCT04479982: Microbial Infection and AMR in Hospitalized Patients With Covid 19
Official title: Microbial Infections and Antimicrobial Resistance (AMR) Patterns Associated With Hospitalized Patients With 2019 Novel Coronavirus Disease (COVID 19)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Covid19
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-07-21
Enrollment: 70
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hospitalized patients with covid 19

Brief summary: To detect microbial infection and AMR associated with COVID 19 infection.

To correlate risk factors of COVID 19 patients with microbial infections and their effects on disease.

Detailed description: The most common type of infection among ICU patients was bacterial or fungal pneumonia; bloodstream and urinary tract infections were also noted. Organisms cultured from patients included pandrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae carbapenemase-producing K. pneumoniae, extended-spectrum β-lactamase (ESBL)- producing K. pneumoniae, ESBL-producing Pseudomonas aeruginosa, Enterobacter cloacae, Serratia marcescens, Aspergillus fumigatus, Aspergillus flavus, Candida albicans, and Candida glabrata .

Eligibility criteria: Inclusion Criteria:

* Patients with Covid infection

Exclusion Criteria:

* Patients without covid 19

Primary outcomes:
measure: Microbial infections and antimicrobial resistance (AMR) patterns associated with hospitalized patients with 2019 novel coronavirus disease (COVID 19)
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut hopital
Study officials:
References:
Clinical trial NCT04083482: Removal of mtDNA in Plasma by Continous Venovenous Hemofiltration in Sepsis
Official title: Removal of mtDNA in Plasma by Continous Venovenous Hemofiltration in Sepsis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Intensive Care Unit
Keywords: Mitochondrial DNA
Sepsis
Continous venovenous hemofiltation
Intensive Care Unit
Lead sponsor: First People's Hospital of Chenzhou
Sponsor class: OTHER
First posted: 2019-09-10
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation（CVVH）

Detailed description: Continous renal replacement therapy （CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .In clinical patients ，continous venovenous hemofoiltration （CVVH）is actually the method of chioce for CRRT in critically ill and hemodynamic instable patients .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index，increasing cardiac index and regulating immune dysfuntion .

Eligibility criteria: Inclusion Criteria:

Adult septic patients undergoing CRRT

Exclusion Criteria:

1. Missing vists
2. transplatation
3. cancer
4. aquired immunodeficiency syndrome

Primary outcomes:
measure: Change of mtDNA concentration in plasma
timeFrame: befor,6hours, 12hours, after CVVH treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Chenzhou
country: China
facility: The First Hospital of Chenzhou
state: Hunan
Study officials:
affiliation: Chenzhou First people Hospital
name: dixian luo, MS
role: STUDY_DIRECTOR
References:
Clinical trial NCT03644082: Computerized Cognitive Training for Patients With Epilepsy
Official title: Computerized Cognitive Training for Patients With Epilepsy
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Epilepsy
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
First posted: 2018-08-23
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a study on the effectiveness of computerized cognitive training for treatment of memory disorders in patients with epilepsy. Participants will be recruited from patients referred for neuropsychological assessment through the NYU Comprehensive Epilepsy Center's inpatient and outpatient services. Individuals meeting inclusion criteria will be screened for the presence of memory disturbance (defined by results of neuropsychological testing) and lack of exposure to any previous form of computerized cognitive training. All eligible subjects will be provided with an account for Lumosity with instructions to complete training modules 5 days per week for a total of 8 consecutive weeks. Outcomes will be evaluated through changes on the neuropsychological test battery.


Eligibility criteria: Inclusion Criteria:

* Documented diagnosis of epilepsy based on medical records. The records will be reviewed by the PI and the approved study personnel to confirm that a diagnosis of epilepsy has been made.
* Presence of memory disturbance, as defined by an immediate or delayed memory index score \< 85 on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
* Availability of a home computer and internet for access to the computer training program.

Exclusion Criteria:

* Full Scale IQ \< 80, as assessed by an appropriate Wechsler scale (WAIS-IV or WASI-II).
* Epilepsy surgery within 8 weeks of the beginning of the trial.
* History of chronic progressive neurologic or neurodegenerative illnesses (e.g., Alzheimer's disease, multiple sclerosis, primary or metastatic malignancy). Patients with headache or migraine are not excluded.
* History of Axis I psychiatric illness with psychotic features. (e.g., schizophrenia or bipolar disorder). Patients with depression or anxiety (treated or untreated) without psychotic features are not excluded.
* Visual or auditory impairment, which precludes participation in part, or all of the testing or computer training.
* English as a first language will not be required, but participants must have either received some of their schooling in English or used English in their work for \>10 years.
* Previous exposure (\> one week) to Lumosity or a similar computerized training program.

Primary outcomes:
measure: Immediate Memory Index Score
timeFrame: 12 Months
measure: Delayed Memory Index Score
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: New York University School of Medicine
state: New York
Study officials:
affiliation: NYU Langone Health
name: William Barr, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT04797182: Avatrombopag for the Primary Prevention of Thrombocytopenia Induced by Cytarabine-based Chemotherapy in Patients With Lymphoma
Official title: Avatrombopag for the Primary Prevention of Thrombocytopenia Induced by Cytarabine-based Chemotherapy in Patients With Lymphoma: An Open, Single-center, Phase II Randomized Controlled Clinical Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Thrombocytopenia
Cytarabine Causing Adverse Effects in Therapeutic Use
Lymphoma
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2021-03-15
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: This phase 2 trial studies the efficacy and safety of Avatrombopag for the primary prevention of thrombocytopenia induced by cytarabine-based chemotherapy in patients with lymphoma


Eligibility criteria: Inclusion Criteria:

* Histologically confirmed lymphoma;
* Patients are scheduled to receive cytarabine-based chemotherapy including Ara-C at dose of 4g/m2.
* Eastern Cooperative Oncology Group (ECOG) of 0-1;
* Proper functioning of the major organs: 1) The absolute value of neutrophils (\>1.5×10\^9/L); platelet count (\> 100×10\^9/L); Hemoglobin (\> 90 g/L); 2) Serum total bilirubin \< 1.5 times ULN; Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) \< 3 times ULN;3) Serum creatinine \<1.5 times Upper Limit Normal (ULN) ; 4) Coagulation function: International Normalized Ratio (INR), Prothrombin Time (PT)\< 1.5 times ULN
* Able to use oral drugs
* Patients volunteer to sign an informed consent
* Life expectancy \> 3 months;
* Contraceptives are used

Exclusion Criteria:

* Thrombocytopenia unrelated to chemotherapy during six months before screening, including but not limited to hypersplenism, infection and hemorrhage.
* In addtion to CIT caused by lymphoma and chemotherapy,patients also suffer from other blood diseases including ALL, AML, myeloid neoplasms, MDS, myeloproliferative disorders, MM;
* A thrombosis of a coronary artery or vein developed during three months before screening;
* Haemorrhage with severe clinical symptoms, such as gastrointestinal and cerebral hemorrhage;
* Platelet transfusion during two days before randomization;
* Allergic to avatrombopag;
* Participation in any other research about novel agents or devices;
* Pregnant or breastfeeding women;
* Researchers consider it unsuitable for patients to participate in this study.

Primary outcomes:
measure: The incidence of grades III and IV thrombocytopenia
timeFrame: 2 years
Secondary outcomes:
measure: The durations of any grade thrombocytopenia and grades II, III and IV thrombocytopenia
timeFrame: 2 years
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Sun Yat-sen University Cancer Center
state: Guangdong
Study officials:
affiliation: Sun Yat-sen University
name: Qingqing Cai, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04628182: The China Laparoscopic Right Hemicolectomy SNAPSHOT
Official title: The China Laparoscopic Right Hemicolectomy SNAPSHOT
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Right Hemicolectomy
Colon Cancer
Lead sponsor: Beijing Friendship Hospital
Sponsor class: OTHER
First posted: 2020-11-13
Enrollment: 1579
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants with non-metastasized right sided colon cancer without ingrowth into other organs suitable for elective radical resection of the ascending colon.

Brief summary: The main objective is to explore the current practice of right hemicolectomy for colon cancer located in the ascending colon and hepatic flexure in selected Chinese high quality and high volume centres. This study will identify a potential area to improve the level of standard care and serve as a reference cohort to which planned standardization and addition of innovative aspects can be compared to


Eligibility criteria: Inclusion Criteria:

* Segmental right sided hemicolectomy (including extended)
* Cancer stage 1-3 (CT-staged)
* No prior abdominal surgery

Exclusion Criteria:

* Stage cT4b, perforated disease
* Acute obstruction
* Emergency surgery
* Right hemicolectomy or ileocaecal resection as part of a large procedure such as subtotal colectomy or panproctocolectomy
* Patients with inflammatory bowel disease (Crohn's disease or ulcerative colitis)

Primary outcomes:
measure: post-operative anastomotic leakages
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Friendship Hospital
state: Beijing
Study officials:
References: