Clinical trial NCT01619280: Safety Study of Nebulized Sodium Nitroprusside in Adult Acute Lung Injury
Official title: A Phase 1 Study: The Determination of the Maximum Tolerable Dosage of Nebulized Sodium Nitroprusside in Adult Acute Lung Injury
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Acute Lung Injury
Acute Respiratory Distress Syndrome
Sodium Nitroprusside
Hypoxia
Respiratory Failure
Keywords: Acute Lung Injury
Acute Respiratory Distress Syndrome
Sodium Nitroprusside
adult
Safety
Dose Finding
Phase 1
3 + 3 design
Nebulizers and Vaporizers
High-Frequency Ventilation
nitric oxide
lung injury
Pulmonary Gas Exchange
Pulmonary Alveoli
Lead sponsor: Mount Sinai Hospital, Canada
Sponsor class: OTHER
First posted: 2012-06-14
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Acute lung injury (ALI) is caused by a wide variety of conditions, but always characterized by hypoxia and non-cardiogenic pulmonary edema. Current treatment of ALI is supportive and treatment of the underlying cause. New therapies to treat severe ALI have not been shown to improve survival, and are limited by financial and logistical resources.

The investigators propose to investigate the role of inhaled sodium nitroprusside (iSNP) in ALI. Sodium nitroprusside (SNP) is a vasodilator. When inhaled, SNP may travel to areas of the lung participating in gas exchange, and cause the blood vessels surrounding these areas to enlarge. This may result in an increase of blood vessels to these areas of the lung, and improve oxygenation. Currently, iSNP has not been studied in the adult population. Therefore, this study is intended to find the safety profile of varying doses of iSNP.

Detailed description: Acute lung injury (ALI) is a syndrome characterized by acute hypoxemic respiratory failure with bilateral pulmonary infiltrates that are not attributed to left atrial hypertension. ALI is responsible for significant mortality and morbidity in the critically ill population.

Novel rescue therapies used to support oxygenation in severe ALI include inhaled nitric oxide and high frequency oscillatory ventilation; however, neither have been shown to reduce mortality and both are limited by logistical and financial challenges.

Inhaled sodium nitroprusside (iSNP) is a vasodilator which causes local vasodilation of pulmonary capillaries surrounding functional alveoli, resulting in improved oxygenation by redistributing pulmonary blood flow to areas with better ventilation-perfusion ratios. As iSNP can be administered by a low-cost nebulizer and is relatively inexpensive compared to other novel rescue therapies, this modality may be an alternative therapy for patients with severe hypoxemia. Two pediatric studies support the use of iSNP in ALI; however, iSNP has not been studied in the adult ALI population. To determine whether iSNP can improve oxygenation in adult ALI, the maximum tolerable dose (MTD) must first be determined.

Our study aims to determine the MTD of iSNP in adult ALI through an open-label, non-randomized, single centered, dose escalation study design, whereby subjects will receive iSNP for thirty minutes and have various physiologic variables recorded.

Eligibility criteria: Inclusion Criteria:

1. Age ≥ 18
2. Negative β-hCG in women of child bearing age (age ≤ 50)
3. Developed ALI within past 72 hours:

   * PaO2/FiO2 \< 300;
   * Bilateral infiltrates on CXR;
   * No clinical evidence of elevated left atrial pressure ie. Heart failure as the cause of hypoxia and bilateral infiltrates; and
   * Recognized risk factor for ALI such as: pneumonia, aspiration pneumonitis, acute pancreatitis, massive blood transfusion, or sepsis
4. FiO2 ≥ 0.5
5. PEEP ≥ 8 cm H2O
6. Invasive arterial blood pressure line
7. Endotracheal intubation or tracheostomy
8. Conventional mechanical ventilation
9. Mean Arterial Pressure (MAP) ≥ 65 mmHg with or without use of vasopressors (stable for at least more than 1 hour)
10. Arterial pH ≥ 7.15

Exclusion Criteria:

1. Chest tube with active leak (eg. bronchopulmonary fistula),
2. Prone ventilation, inhaled nitric oxide, inhaled prostacyclin, high frequency oscillatory ventilation,
3. Lack of consent,
4. Untreated coarctation of aorta, symptomatic or severe/critical aortic stenosis as documented by echocardiogram or clinical history,
5. Evidence of increased intracranial pressure (eg. dilated pupils, known intracranial trauma or mass on head CT),
6. SpO2 \<90%,
7. Contraindication to SNP i.e. hypersensitivity, congenital optic atrophy, tobacco amblyopia,
8. Active treatment with IV or transdermal nitroglycerin,
9. G6PD deficiency
10. CrCl \< 30 ml/min or receiving renal replacement therapy, or
11. Total bilirubin \> 68 µmol/L and AST or ALT level 2 times the upper limit of normal.

Primary outcomes:
measure: The maximum tolerable dosage of nebulized sodium nitroprusside. This will be determined by the 3 + 3 dose finding design.
timeFrame: Up to 1 year
Secondary outcomes:
measure: The change in measures of oxygenation (PaO2,SaO2,oxygenation index) during iSNP administration.
timeFrame: 0 min, 15 min, 30 min, and 45 min
measure: The change in heart rate (HR), mean blood pressure (MAP) during iSNP administration.
timeFrame: 0 min, 15 min, 30 min, and 45 min
measure: The presence or absence of lactate, and/or methemoglobin.
timeFrame: 0 min, 15 min, 30 min, and 45 min
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Mount Sinai Hospital, University of Toronto
state: Ontario
Study officials:
affiliation: Department of Critical Care Medicine, University of Toronto
name: Sangeeta Mehta, MD FRCPC
role: PRINCIPAL_INVESTIGATOR
affiliation: Department of Critical Care Medicine, University of Toronto
name: Terence Ip, MD
role: PRINCIPAL_INVESTIGATOR
References: