Clinical trial NCT04213482: Evaluating Radiomorphometric Indices and Fractal Dimension of the Pediatric Oncology Patients on Panoramic Images
Official title: Evaluating Radiomorphometric Indices and Fractal Dimension of the Pediatric Oncology Patients on Panoramic Images
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Oncology
Bone Loss
Keywords: pediatric oncology
fractal analysis
panoramic mandibular indices
radiotherapy
chemotherapy
Lead sponsor: Nuh Naci Yazgan University
Sponsor class: OTHER
First posted: 2019-12-30
Enrollment: 100
Sex: ALL
Minimum age (years): 6
Maximum age (years): 23
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients received chemotherapy and radiotherapy for a Pediatric oncologic disease

Brief summary: This study evaluated pediatric oncology patients in terms of quality of bone and determine any relation between bone quality and radiotherapy/chemotherapy. The alternative hypothesis is that the bone quality of the oncology patients who received radiotherapy/chemotherapy is lower than the control group.

Detailed description: Cancer is the abnormal and uncontrolled proliferation of certain tissues in the body for a reason that cannot be determined yet. Childhood cancers occur between 0-17 years of age, and follow-up and treatment of these patients are performed in pediatric oncology services. Diagnosis in childhood cancers can be made by clinical examination as well as blood tests and examination of tissue samples. There are also some imaging methods used for diagnosis; ultrasonography, computed tomography, magnetic resonance imaging, positron emission tomography / computed tomography (PET / CT).

Treatment methods in childhood cancers are as follows; surgery, chemotherapy, radiotherapy and stem cell transplantation. Once diagnosed, oncologists and surgeons may choose one of these treatment options by mutual consultation or decide on a treatment method. Fractal analysis is a numerical as fractal dimension. Trabeculae are thin columns with numerous large spaces that give a honeycomb or spongy appearance of cancellous bone, which is also called trabecular bone or spongy bone. Previously, fractal analysis has been reported as a useful method to detect various diseases that affect the trabecular bone structure. Particularly in the field of dentistry, studies have shown that fractal analysis by the box-counting method can successfully evaluate trabecular changes in the mandible of patients with osteoporosis and periodontal diseases and in lactating women.

Eligibility criteria: Inclusion Criteria:

* to have been treated for any oncological diseases in childhood
* oncological treatment completed at least one year ago

Exclusion Criteria:

* ongoing oncological treatment
* patients who unwilling to participate to study

Primary outcomes:
measure: Bone Mineral Density (BMD)
timeFrame: Participants to undergo a single assessment; to be measured at least 1 year after completion of oncologic therapy
Secondary outcomes:
Other outcomes:
Locations:
city: Kayseri
country: Turkey
facility: Nuh Naci Yazgan University
state: Kocasinan
Study officials:
References: