Clinical trial NCT05798182: Ultrasound Markers of Systemic Inflammation
Official title: Ultrasound in the Intensive Care Unit and Measurable Indicators of Systemic Inflammation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Inflammation Process
Endothelial Dysfunction
Vasomotor Arterial Disorder
Vascular Dilation
Swelling; Hand
Keywords: Intensive Care, Surgical
Ultrasonography, Doppler
Inflammation
Lead sponsor: Osijek University Hospital
Sponsor class: OTHER
Collaborators: name: Josip Juraj Strossmayer University of Osijek
First posted: 2023-04-04
Enrollment: 61
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The patients in Osijek University Hospital who are admitted in the ICU will be included in the study.

Brief summary: The aim of this study was to measure whether the flow rate through the brachial artery and inflammatory markers were associated with the development of tissue edema in the surgical intensive care unit patients.

Detailed description: The study was performed using a ultrasound machine with linear probe settings at 50 mm depth and 40 decibel \[dB\] gain that did not change during the study. The probe was placed on vascular ultrasound measurement. The diameter of the brachial artery in the middle of the upper arm and the flow rate through the artery was measured on postoperative days 1 and 2. The presence of the edema was measured above the 3rd metacarpal bone as the distance from the skin surface to the periosteum. An average of three assessments was shown. Patient's age, body mass index (BMI), type of admission, white blood cells (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were also registered.

Eligibility criteria: Inclusion Criteria:

* Adults over 18 years of age
* Postoperative surgical patients
* Signed informed consent

Exclusion Criteria:

* Refusal to give informed consent
* A previous thromboembolic event of the brachial artery
* Acute infection of the upper extremity

Primary outcomes:
measure: Diameter of brachial artery - 1
timeFrame: within 4 hours of admission.
measure: Diameter of brachial artery - 2
timeFrame: day 2 after admission is between 24 and 48 hours after admission.
measure: Brachial artery flow velocity - 1
timeFrame: within 4 hours of admission to ICU.
measure: Brachial artery flow velocity - 2
timeFrame: day 2 after admission is between 24 and 48 hours after admission.
measure: Distance from skin to third metacarpal bone -1
timeFrame: within 4 hours of admission.
measure: Distance from skin to third metacarpal bone - 2
timeFrame: day 2 after admission is between 24 and 48 hours after admission.
measure: White blood cell count - 1
timeFrame: within 4 hours of admission.
measure: White blood cell count - 2
timeFrame: day 2 after admission is between 24 and 48 hours after admission.
measure: C-reactive protein - 1
timeFrame: within 4 hours of admission.
measure: C-reactive protein - 2
timeFrame: day 2 after admission is between 24 and 48 hours after admission.
measure: Procalcitonin - 1
timeFrame: within 4 hours of admission.
measure: Procalcitonin - 2
timeFrame: Day 2 after admission is between 24 and 48 hours after admission.
Secondary outcomes:
Other outcomes:
Locations:
city: Osijek
country: Croatia
facility: Slavica Kvolik
Study officials:
affiliation: Osijek University Hospital
name: Slavica Kvolik, M.D., PhD,
role: STUDY_DIRECTOR
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