Clinical trial NCT03709095: Sprint Interval Training During Rehabilitation After Spinal Cord Injury
Official title: Sprint Interval Training During Rehabilitation After Spinal Cord Injury
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Spinal Cord Injuries
Rehabilitation
Exercise
Keywords: Inpatient Rehabilitation
Sprint interval training
Exercise
Spinal Cord Injury
Lead sponsor: McMaster University
Sponsor class: OTHER
Collaborators: name: Hamilton Health Sciences Corporation
First posted: 2018-10-17
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants were randomized to one of two groups: (A) sprint interval training (SIT) or (B) moderate intensity continuous training (MICT).
Primary purpose: SUPPORTIVE_CARE

Brief summary: Immediately following a spinal cord injury (SCI), patients are admitted to inpatient rehabilitation where they undergo physical reconditioning in preparation for a return to home setting. The current standard of practice for aerobic training is performing arm-ergometry for 25 mins at a frequency of three times per week. Given the move towards shortened length of stay during inpatient rehabilitation, performing MICT can consume a considerable amount of therapy time. Sprint interval training (SIT) has been shown to elicit similar improvements in physical capacity, despite a reduced time commitment to MICT. However, there are no controlled trials comparing the effects of SIT to MICT in individuals with SCI undergoing inpatient rehabilitation. The primary aim of this study was to investigate the efficacy of a five-week, thrice weekly 10 min SIT program and compare outcome measures to a traditional 25 minute MICT program on the arm-ergometer in individuals with SCI undergoing inpatient clinical rehabilitation. It was hypothesized that five weeks of SIT and MICT would induce similar changes in maximal and sub-maximal exercise performance, self-efficacy for exercise, and exercise enjoyment, despite large differences in training volume and time commitment. It was also hypothesized that SIT would be well tolerated and elicit higher levels of cardiovascular strain than MICT.


Eligibility criteria: Inclusion Criteria:

* Participants with sub-acute spinal cord injury (time since injury: 14 - 182 days)
* Undergoing inpatient rehabilitation
* Aged 18-65 years
* Injury level at the second cervical vertebrae (C2) or below

Exclusion Criteria:

- Unable to perform arm-ergometry training

Primary outcomes:
measure: Change in peak power output
timeFrame: Change in peak power output from baseline to 5 weeks
measure: Change in sub-maximal arm-ergometry
timeFrame: Change in sub-maximal arm-ergometry from baseline to 5 weeks
Secondary outcomes:
measure: Cardiovascular Responses
timeFrame: Throughout each week of training (Week 1,Week 2, Week 3, Week4, Week 5)
measure: Perceptual Responses
timeFrame: Throughout each week of training (Week 1,Week 2, Week 3, Week4, Week 5)
measure: Change in self-efficacy for exercise
timeFrame: Change in self-efficacy from baseline to 5 weeks
measure: Exercise Satisfaction
timeFrame: Measured only at the end of the intervention (5 weeks)
measure: Pain perceptions
timeFrame: Measured only at the end of the intervention (5 weeks)
Other outcomes:
Locations:
city: Hamilton
country: Canada
facility: McMaster University
state: Ontario
Study officials:
affiliation: McMaster University
name: Audrey L Hicks, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gillen JB, Martin BJ, MacInnis MJ, Skelly LE, Tarnopolsky MA, Gibala MJ. Twelve Weeks of Sprint Interval Training Improves Indices of Cardiometabolic Health Similar to Traditional Endurance Training despite a Five-Fold Lower Exercise Volume and Time Commitment. PLoS One. 2016 Apr 26;11(4):e0154075. doi: 10.1371/journal.pone.0154075. eCollection 2016.
citation: Hicks AL, Martin KA, Ditor DS, Latimer AE, Craven C, Bugaresti J, McCartney N. Long-term exercise training in persons with spinal cord injury: effects on strength, arm ergometry performance and psychological well-being. Spinal Cord. 2003 Jan;41(1):34-43. doi: 10.1038/sj.sc.3101389.
citation: Nightingale TE, Metcalfe RS, Vollaard NB, Bilzon JL. Exercise Guidelines to Promote Cardiometabolic Health in Spinal Cord Injured Humans: Time to Raise the Intensity? Arch Phys Med Rehabil. 2017 Aug;98(8):1693-1704. doi: 10.1016/j.apmr.2016.12.008. Epub 2017 Jan 13.
citation: Astorino TA, Thum JS. Within-session responses to high-intensity interval training in spinal cord injury. Disabil Rehabil. 2018 Feb;40(4):444-449. doi: 10.1080/09638288.2016.1260648. Epub 2016 Dec 8.