louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06102382: The Effect of Two Different Doses of Noradrenaline on Hypotension Caused by Spinal Anesthesia for Cesarean Section
Official title: The Effect of Two Different Doses of Noradrenaline on Hypotension Caused by Spinal Anesthesia for Cesarean Section
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Cesarean Section
Hypotension
Norepinephrine
Keywords: Norepinephrine
Spinal anesthesia
Hypotension
Cesarean section
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-10-26
Enrollment: 100
Sex: FEMALE
Minimum age (years): 19
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare two infusion rates of norepinephrine for prophylaxis against post-spinal hypotension during caesarean delivery.

Detailed description: Hypotension after spinal anesthesia for cesarean delivery is common and is caused mainly by peripheral vasodilatation. Although the intravenous administration of fluids helps, it does not always prevent maternal hypotension. Usually, this hypotension is treated with phenylephrine or ephedrine.

Norepinephrine has been recently introduced for prophylaxis against post-spinal hypotension during cesarean delivery due to its α-adrenergic activity in addition to the weak β-adrenergic activity.

Although the use of norepinephrine for this purpose has shown promising results. However, no sufficient data are available with regard to its optimum dose.

The objective of this study is to compare two infusion rates of norepinephrine for prophylaxis against post-spinal hypotension during caesarean delivery.

Eligibility criteria: Inclusion Criteria:

* Pregnant women scheduled for cesarean section under spinal anesthesia
* Gestational age of at least 37 weeks

Exclusion Criteria:

* Patient refusal
* Contraindications of spinal anesthesia
* Allergy to the study drug
* Height\<150 cm, weight \< 60 kg, body mass index (BMI) ≥40 kg/m2.
* patients with cardiac morbidities
* Hypertensive disorders of pregnancy.
* Prepartum hemorrhage

Primary outcomes:
measure: The frequency of post-spinal hypotension
timeFrame: During the first hour after the subarachnoid block
Secondary outcomes:
measure: Arterial blood pressure (Systolic, diastolic, and mean)
timeFrame: During the first hour after the subarachnoid block
measure: Heart rate
timeFrame: During the first hour after the subarachnoid block
measure: Doses of atropine and ephedrine
timeFrame: Intraoperative
measure: Appearance, Pulse, Grimace, Activity, Respiration (APGAR) score
timeFrame: 1, 5, and 10 minutes after delivery
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05805982: Educational Video Versus In-person Genetic Counseling for Hereditary Cancer
Official title: Randomized Non Inferiority Trial of Educational Video Versus In-person Genetic Counseling for Hereditary Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Genetic Counseling
Hereditary Cancer
Lead sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Sponsor class: OTHER
First posted: 2023-04-10
Enrollment: 251
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The identification of mutations in cancer susceptibility genes is important as it makes it possible to recommend specific cancer treatments, implement risk reduction strategies or early detection of cancer, and identify family members at risk. The guidelines for evaluating patients who are candidates for genetic testing recommend pre-test genetic counseling. However, the limited number of specialists trained to provide genetic counseling worldwide, and particularly in developing countries such as Mexico, makes it difficult to implement such recommendations. The present proposal aims to compare, through a randomized non-inferiority study, a pre-test education strategy using a pre-recorded video against in-person counseling. This strategy could potentially increase access in places with limited resources.

The general hypothesis of the research is that patients who are candidates for cancer genetic susceptibility testing who receive pre-test education via video will consent to genetic testing in the same proportion as those who receive it during an in-person visit.

The specific objectives of the study include: 1) to compare the proportion of patients who are tested in both groups; 2) to assess knowledge about hereditary cancer in both groups after the intervention; 3) assess anxiety symptoms in both groups after the intervention; and 4) assess satisfaction with the information received during the intervention.Patients \>18 years of age who meet the criteria for genetic testing to evaluate genetic cancer susceptibility genes and who have not previously undergone genetic testing or genetic counseling will be invited. The intervention group will receive education via pre-recorded video and the control group will receive genetic counseling during an in-person consultation.


Eligibility criteria: Inclusion Criteria:

* Meet cancer genetic testing criteria

Exclusion Criteria:

* Had a genetic testing before
* Had genetic counseling before

Primary outcomes:
measure: Genetic testing acceptance
timeFrame: up to 12 weeks
Secondary outcomes:
measure: Genetic cancer knowledge change (pre and post intervention)
timeFrame: up to 24 hours after intervention
measure: Anxiety level (pre and post intervention)
timeFrame: up to 24 hours after intervention
Other outcomes:
Locations:
city: Mexico City
country: Mexico
facility: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Study officials:
References:
Clinical trial NCT06409182: A Prospective Pilot Study to Evaluate the Diagnostic Performance of a Wireless Sensor Capsule in Detection of UGIB
Official title: A Prospective Pilot Study to Evaluate the Diagnostic Performance of a Wireless Sensor Capsule in Detection of Upper Gastrointestinal Bleeding
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: UGI Bleed
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2024-05-10
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Patient will swallow wireless sensor capsule to determine if there's
Primary purpose: DIAGNOSTIC

Brief summary: It is a single-center, prospective study, which will be conducted in a tertiary academic hospital (Prince of Wales Hospital). All subjects will undergo a paired examination of HemoPill® acute capsule and oesophago-gastro-duodenoscopy (OGD).

Detailed description: It is a single-center, prospective study, which will be conducted in a tertiary academic hospital (Prince of Wales Hospital). All subjects will undergo a paired examination of HemoPill® acute capsule and oesophago-gastro-duodenoscopy (OGD).

Eligibility criteria: Inclusion Criteria:

Subjects are eligible if:

* They have symptoms and signs of suspected UGIB (melena, per rectal bleeding, coffee ground vomiting, history of hematemesis);
* They will undergo OGD within 24 hours;
* Written consent obtained.

Exclusion Criteria:

Subjects will be excluded from the study if they have any of the followings:

* Contraindications for OGD (e.g. respiratory failure, suspected perforation);
* Contraindications for capsule endoscopy (e.g. known gastrointestinal obstruction or stricture, severe dysphagia, impaired consciousness);
* Cardiac pacemaker or implanted electromedical devices;
* History of gastrectomy or bowel resection;
* Active ongoing fresh hematemesis;
* Unstable hemodynamics despite adequate resuscitation;
* Advanced comorbidities (defined as American Society of Anesthesiologists grade 4 or above);
* Pregnancy.

Primary outcomes:
measure: Area under the ROC curve
timeFrame: duration of study, 2 hours
Secondary outcomes:
measure: Sensitivity
timeFrame: duration of study, 2 hours
measure: Specificity
timeFrame: duration of study, 2 hours
measure: Positive predictive value
timeFrame: duration of study, 2 hours
measure: Negative predictive value
timeFrame: duration of study, 2 hours
measure: Technical success rate
timeFrame: duration of study, 2 hours
measure: Adverse event rate
timeFrame: duration of study, 2 hours
measure: Time to a positive HI signal
timeFrame: duration of study, 2 hours
measure: Time to OGD from Hemopill capsule examination
timeFrame: duration of study, 2 hours
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Prince of Wales Hospital
Study officials:
References:
Clinical trial NCT01551082: Outpatient Chest Tube Management Following Thoracic Resection Improves Patient Length of Stay and Satisfaction Without Compromising Outcomes
Official title: Outpatient Chest Tube Management Following Thoracic Resection Improves Patient Length of Stay and Satisfaction Without Compromising Outcomes
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Lung Cancer
Pneumothorax
Subcutaneous Emphysema
Lead sponsor: Alliance of Cardiothoracic and Vascular Surgeons
Sponsor class: OTHER
First posted: 2012-03-12
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 89
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing thoracic resection by one surgeon with post operative air leak being discharged home with chest tube and portable drainage device.

Brief summary: Discharging patients home with air leak and chest tube to portable drainage device after thoracic resection is cost effective and safe without compromising patients outcome or satisfaction. Despite good outcomes this practice is not done universally by thoracic surgeons.

Detailed description: Medical chart database to identify patients ,of one thoracic surgeon over the last seven years, who underwent thoracic resection and were discharged home with an air leak and chest tube to portable drainage device was completed. Once all patients were identified, all possible vulnerable patients were discarded. Written consent for participation was obtained by eligible patients and subjects willing to participate were given further explanation of the study. All willing participants completed an Outpatient Chest Tube Quality of Life Questionnaire. Upon completion of the questionnaire participants involvement in the study was complete. Data was collected and correlations between variables statistically analysed to determine significant factors affecting care.

Eligibility criteria: Inclusion Criteria:

* all patients 18-89,
* all genders,
* all patients undergoing thoracic resection,
* all patients discharged with chest tube

Exclusion Criteria:

* minors,
* all patients \> 90 years old,
* all mentally challenged,
* all non-English speaking patients

Primary outcomes:
measure: Outpatient Chest Tube Management Following Thoracic Resection Improves Patient Length of Stay and Satisfaction Without Compromising Outcomes
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Chattanooga
country: United States
facility: Memorial Hospital
state: Tennessee
Study officials:
affiliation: Alliance of Cardiac Thoracic and Vascular Surgeons
name: Jeremy S Smith, BSN
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04764682: Determining Molecular Drivers of Radiation Dermatitis
Official title: Determining Molecular Drivers of Radiation Dermatitis
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2021-02-21
Enrollment: 20
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult women aged 18 years and older

Brief summary: This study is being conducted to address key gaps in current knowledge and set the stage for rational design of strategies to prevent (pre-exposure to radiation), mitigate (post-exposure to radiation before overt signs/symptoms appear), and/or treat (post-onset of signs/symptoms) radiation dermatitis (itchy, dry skin or a rash on swollen, reddened skin).


Eligibility criteria: Inclusion Criteria:

* Patients receiving standard-of-care postoperative radiation therapy (2-2.7 Gy per fraction) to the breast and/or chest wall for breast cancer treatment.
* Tissue diagnosis of breast cancer.
* Age \> 18 years
* Signed informed consent.
* Complete blood count within normal limits within the preceding 2 weeks.

Exclusion criteria:

* Induction chemotherapy or biologic therapy
* Concurrent chemotherapy or biologic therapy
* Autoimmune disease with skin manifestations - psoriasis, dermatomyositis, scleroderma, eczema, polymyositis
* Allergy to lidocaine anesthesia
* Known bleeding diathesis (anticoagulation with warfarin, coagulation/bleeding disorders, vitamin C or K deficiency, thrombocytopenia)
* History of keloids or easy scarring

Primary outcomes:
measure: Change in skin
timeFrame: Baseline, final week of radiation
Secondary outcomes:
Other outcomes:
Locations:
city: Jacksonville
country: United States
facility: Mayo Clinic
state: Florida
Study officials:
affiliation: Mayo Clinic
name: Laura Vallow, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01674582: Treatment Effects Inclusive Cognitive Impact and Possibilities to Individually Adjusted Treatment in Patients With Intracranial Tumors With Clinical, Neuropsychological and Imaging Parameters
Official title: Treatment Effects Inclusive Cognitive Impact and Possibilities to Individually Adjusted Treatment in Patients With Intracranial Tumors With Clinical, Neuropsychological and Imaging Parameters.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intracranial Tumor
Keywords: Glioma
Brain tumors
Brain metastases
MRI
Cognitive measurement
Neuropsychological evaluation
DW-MRI
P-MRI
MRS
Lead sponsor: Lund University Hospital
Sponsor class: OTHER
First posted: 2012-08-29
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The main purposes with this trial is to investigate the potential of MRI with diffusion and blood volume, flow in brain to diagnose and to measure treatment effects in patients with intracranial tumors, especially gliomas and metastases in a prospective trial, to evaluate the possibilities to individually adjusted treatment in this category of patients depending on treatment outcomes measured by MRI, to perform clinical follow up in connection with MRI to evaluate a correlation and to perform testing of cognitive ability before, during, and after treatment and to investigate if given treatment causes any decrease in the patients habitual state.


Eligibility criteria: Inclusion Criteria:

* Age 18 years or older
* Suspected primary brain tumor, verified glioblastoma or non surgically treated metastases from solid tumor
* Increasing MRI changes in patients with previous verified glioblastoma
* Be able to speak Swedish without difficulties (because of the neuropsychological investigations)
* Written informed concent

Exclusion Criteria:

* Unability to perform MRI

Primary outcomes:
measure: Early prediction of treatment response based on MRI parameters.
timeFrame: Three weeks compared to baseline.
Secondary outcomes:
measure: Neuropsychological function.
timeFrame: Month 3, 12, and 18 compared to baseline
Other outcomes:
Locations:
city: Lund
country: Sweden
facility: Lund University Hospital
Study officials:
affiliation: Skåne University Hospital Lund
name: Pia Maly Sundgren, MD. PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00197782: The Immediate and Longterm Immune Responses of UK Infants and Young Children to a Booster Dose of Hib Vaccine
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Haemophilus Influenzae Type b
Lead sponsor: Public Health England
Sponsor class: OTHER_GOV
First posted: 2005-09-20
Sex: ALL
Minimum age (years): 9
Maximum age (years): 4
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: To measure the magnitude and persistence of the antibody response to a booster dose of Hib conjugate vaccine given between 9 months and 4 years of age to UK children who had completed primary immunisation with 3 doses of Hib vaccine given at 2/3/4 months of age either as a combined D/T/wholecellpertussis/Hib or D/T/acellularpertussis/Hib vaccine.


Eligibility criteria: Inclusion Criteria:

* Written informed consent from parent or legal guardian of the infant or child
* Age \>= 9 months and \<4 years at recruitment
* Eligible to receive a single dose of Hib vaccine as per the UK schedule
* Receipt of three doses of Hib vaccine in infancy

Exclusion Criteria:

* History of Hib infection
* History of severe local reaction that can be confidently related to a prior Hib immunisation
* Deferral of vaccination if acute illness and/or temperature \>38C on day of vaccination

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Public Health England
name: Elizabeth Miller, MBBS FRCPath
role: PRINCIPAL_INVESTIGATOR
References:
citation: Southern J, McVernon J, Gelb D, Andrews N, Morris R, Crowley-Luke A, Goldblatt D, Miller E. Immunogenicity of a fourth dose of Haemophilus influenzae type b (Hib) conjugate vaccine and antibody persistence in young children from the United Kingdom who were primed with acellular or whole-cell pertussis component-containing Hib combinations in infancy. Clin Vaccine Immunol. 2007 Oct;14(10):1328-33. doi: 10.1128/CVI.00191-07. Epub 2007 Aug 15.
Clinical trial NCT02199782: Pilot Study of Cognitive Assessment in Welsh Speakers
Official title: Pilot Study of Cognitive Assessment in Welsh Speakers
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cognitive Impairment - e.g. Dementia
Lead sponsor: National Health Service, United Kingdom
Sponsor class: OTHER_GOV
Collaborators: name: Betsi Cadwaladr University Health Board
First posted: 2014-07-24
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: 19% of Wales' population speaks Welsh. Under the Welsh Language Act 1993, every public body providing services to the public in Wales has to prepare a scheme setting out how it will provide those services in Welsh.

Diagnosing dementia requires a comprehensive assessment, an essential component of which is a cognitive assessment tool, which takes the form of a questionnaire. In clinical practice, this is currently only available through the medium of English.

The investigators objective is to measure the difference between Cognitive Assessment scores (using the Montreal cognitive assessment (MoCA)), when done in English and Welsh, in those who are cognitively impaired and whose first language is Welsh. The investigators predict that there will be a significant difference in scores in favour of the Welsh-medium tests, thus proving that the current mode of administering the test is prejudiced against patients whose first language is Welsh.

If the investigators predictions are correct, then the investigators would seek to introduce a validated Welsh-language cognitive assessment tool to the domain of the Welsh NHS.


Eligibility criteria: Inclusion Criteria:

* Welsh Speakers - self-identify as first-language Welsh
* Diagnosis of Dementia - recorded in patient's case notes

Exclusion Criteria:

* Refusal
* Intercurrent illness
* Blind/any other disability which may prevent participant from fully completing Cognitive Assessment

Primary outcomes:
measure: Difference in Cognitive Assessment Score between Welsh and English
timeFrame: at 0 and 48 hrs
Secondary outcomes:
measure: To measure the differences between participants' scores in Welsh and English and compare between different types of Dementia
timeFrame: 0 and 48hrs
Other outcomes:
Locations:
city: Bodelwyddan
country: United Kingdom
facility: Ysbyty Glan Clwyd
state: Denbighshire
Study officials:
affiliation: BCUHB NHS
name: Sion Jones, MBBCh
role: PRINCIPAL_INVESTIGATOR
References:
citation: Cummings JL, Benson F, Hill MA, Read S. Aphasia in dementia of the Alzheimer type. Neurology. 1985 Mar;35(3):394-7. doi: 10.1212/wnl.35.3.394.
citation: Mendez MF, Perryman KM, Ponton MO, Cummings JL. Bilingualism and dementia. J Neuropsychiatry Clin Neurosci. 1999 Summer;11(3):411-2. doi: 10.1176/jnp.11.3.411. No abstract available.
Clinical trial NCT05501782: Evaluation of Intuitive Eating and Hedonic Hunger in University Students
Official title: Evaluation of Intuitive Eating and Hedonic Hunger Status and the Effects of Intuitive Eating and Hedonic Deficit on Body Mass Index, Mental Health and Sleep Quality in University Students.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: INTUITIVE EATING
Hedonic Hunger
Lead sponsor: Istanbul Medeniyet University
Sponsor class: OTHER
First posted: 2022-08-15
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 36
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: University students who agreed to participate in the study

Brief summary: This study was conducted with the participation of 62 female and 38 male students between the ages of 18-36 studying at various universities. A questionnaire consisting of seven parts was applied to the participants. In the first part, 20; demographic data and general health status of the participants; There were 11 questions including nutritional habits and anthropometric measurements (body weight and height). The other parts of the questionnaire were the Intuitive Eating Scale (IES-2), Power of Food Scale (PFS-Tr), Food Craving Questionnaire (FCQ-T), the Pittsburg Sleep Quality Scale (PUKI), Warwick-Edinburgh Mental Well-Being Scale (WEMWBS) and Palatable Eating Motive Scale (PEMS), respectively contains. Consent from the participants was also obtained with the questionnaire form.


Eligibility criteria: Inclusion Criteria:

* University students who agreed to participate in the study

Exclusion Criteria:

* University students who did not want to participate in the study baby and kids elderly adolescents pregnant women breastfeeding mothers

Primary outcomes:
measure: Intuitive eating scale (IES-2)
timeFrame: 2 months
measure: Power of food scale (PFS)
timeFrame: 2 months
measure: Food Craving Questionnaire (FCQ)
timeFrame: 2 months
measure: Pittsburg Sleep Quality Scale (PUKI)
timeFrame: 2 months
measure: Warwick-Edinburgh Mental Well-Being Scale (WEMWBS)
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: