Clinical trial NCT03486873: Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Official title: A Multicenter, Open-label, Phase 3 Study to Evaluate the Long-term Safety and Efficacy in Participants Who Are Currently on Treatment or in Follow-up in Studies That Include Pembrolizumab
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Solid Tumors
Hematologic Malignancies
Keywords: PD1
PD-1
PDL1
PD-L1
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
First posted: 2018-04-03
Enrollment: 3500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the long-term safety and efficacy of pembrolizumab (MK-3475) in participants from previous Merck pembrolizumab-based parent studies who transition into this extension study.

This study will consist of three phases: 1) First Course Phase, 2) Survival Follow-up Phase or 3) Second Course Phase. Each participant will transition to this extension study in one of the following three phases, depending on the study phase they were in at the completion of the parent study. Participants who were in the First Course Phase of study treatment with pembrolizumab or lenvatinib in their parent study will enter the First Course Phase of this study and complete up to 35 doses or more every 3 weeks (Q3W) or 17 doses or more every 6 weeks (Q6W) of study treatment with pembrolizumab or a pembrolizumab-based combination or lenvatinib according to arm assignment. Participants who were in the Follow-up Phase in the parent study (post-treatment or Survival Follow-up Phase) will enter the Survival Follow-up Phase of this study. Participants who were in the Second Course Phase in their parent study will enter Second Course Phase of this study and complete up to 17 doses Q3W or 8 doses Q6W of study treatment with pembrolizumab or a pembrolizumab-based combination according to arm assignment.

Any participant originating from a parent trial where crossover to pembrolizumab was permitted upon disease progression may be eligible for 35 doses as Q3W or 17 doses Q6W of pembrolizumab (approximately 2 years), if they progress while on the control arm and pembrolizumab is approved for the indication in the country where the potential eligible crossover participant is being evaluated.


Eligibility criteria: Inclusion Criteria:

* Treated on the parent pembrolizumab studies established by the Sponsor as MK-3475-587 ready.
* Currently receiving pembrolizumab, pembrolizumab based combinations or lenvatinib from parent studies or in a follow-up phase.

Additional eligibility criteria for participants who enter Second Course Phase once they are enrolled on MK-3475-587:

* Has not received any anticancer systemic treatment since the last dose of pembrolizumab or a pembrolizumab-based combination in First Course Phase.
* Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Demonstrates adequate organ function.
* Have resolution of any toxic effect(s) of First Course Phase trial treatment with pembrolizumab or a pembrolizumab-based combination to Grade 1 or less (except alopecia) before trial treatment in Second Course Phase is started. If participant received major surgery or radiation therapy of \>30 Gray (Gy), they must have recovered from the toxicity and/or complications of the intervention.
* A female participant is eligible to enroll if she is not pregnant, not breastfeeding, and ≥1 of the following conditions applies: A woman of childbearing potential (WOCBP) who agrees to use contraception during the study treatment period and for ≥120 days (corresponding to time needed to eliminate any study combination treatment(s) plus 30 days (a menstruation cycle) for study treatments with risk of genotoxicity.

Additional eligibility criteria for participants who enter dosing with Lenvatinib:

* Adequately controlled blood pressure (BP) to \<150/90 mmHg, with or without antihypertensive medications.
* For male agrees to be abstinent from penile-vaginal intercourse OR agrees to use a highly effective contraceptive method while receiving study drug and for 7 days after the last dose of lenvatinib.
* Is female and not pregnant/breastfeeding and at least one of the following applies during the study and for ≥4 days after: is not a woman of childbearing potential (WOCBP), is a WOCBP and uses highly effective contraception (low user dependency method OR a user dependent hormonal method in combination with a barrier method) or is a WOCBP who is abstinent from heterosexual intercourse.

Exclusion Criteria:

-There are no exclusion criteria to participate in MK-3475-587.

Participants are excluded from entering Second Course trial treatment once they are enrolled on MK-3475-587 if any of the following criteria applies:

* Has severe hypersensitivity (≥ Grade 3) to pembrolizumab and/or any of its excipients.
* Has received a live vaccine within 30 days prior to the first dose of Second Course Phase trial treatment.
* Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the Cycle 1 Day 1 of Second Course Phase.
* Has a known additional malignancy that is progressing or requires active treatment. Exceptions include early stage cancers (carcinoma in situ or Stage 1) treated with curative intent, melanoma (non-ulcerated, thin primary), basal cell carcinoma of the skin, squamous cell carcinoma of the skin, in situ cervical cancer, or in situ breast cancer that has undergone potentially curative therapy.
* Has known active central nervous system metastases and/or carcinomatous meningitis.
* Has an active autoimmune disease that has required systemic treatment in the past 2 years (i.e., use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed.
* Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis. Note: Participants that experienced pneumonitis during First Course that did not meet the criteria for permanent discontinuation are eligible.
* Non-small cell lung cancer (NSCLC) participants only: Has interstitial lung disease.
* Has an active infection requiring systemic therapy.
* Has a known history of human immunodeficiency virus (HIV) infection.
* Has a known history of or is positive for hepatitis B or hepatitis C. For parent studies where inclusion of participants with hepatitis was permitted, MK-3475-587 will follow the parent study eligibility criteria for hepatitis.
* Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the Second Course Phase eligibility Visit through 120 days after the last dose of study treatment.
* Has severe cardiovascular disease, i.e., arrhythmias, requiring chronic treatment, congestive heart failure (New York Heart Association Class III or IV) or symptomatic ischemic heart disease.
* Has hepatic decompensation (Child-Pugh score \>6 \[class B and C\]).
* Has uncontrolled thyroid dysfunction.
* Has uncontrolled diabetes mellitus.
* Has had an allogeneic tissue/solid organ transplant.
* Has a known history of active tuberculosis (TB; Bacillus tuberculosis).

Additional exclusion criteria for participants who enter dosing with Lenvatinib:

* Has had major surgery within 3 weeks prior to first dose of study intervention(s).
* Has preexisting ≥Grade 3 gastrointestinal or non-gastrointestinal fistula.
* Has urine protein ≥1 g/24 hours.
* Has LVEF below the institutional (or local laboratory) normal range, as determined by multigated acquisition scan (MUGA) or echocardiogram (ECHO).
* Has radiographic evidence of encasement or invasion of a major blood vessel, or of intratumoral cavitation.
* Prolongation of QT intervals corrected for heart rate using Fridericia's (cube root) correction (QTcF) interval to \>480 ms.
* Has clinically significant cardiovascular disease within 12 months from first dose of study intervention, including New York Heart Association Class III or IV congestive heart failure, unstable angina, myocardial infarction, cerebral vascular accident, or cardiac arrhythmia associated with hemodynamic instability.
* Gastrointestinal malabsorption or any other condition that might affect the absorption of lenvatinib.
* Active hemoptysis (bright red blood of at least 0.5 teaspoon) within 3 weeks prior to the first dose of study drug.
* Has a history of any contraindication or has a severe hypersensitivity to any components of lenvatinib.

Primary outcomes:
measure: Overall Survival (OS)
timeFrame: Up to approximately 10 years
Secondary outcomes:
measure: Modified Progression Free Survival (PFS) Per Evaluation Criteria Used in the Parent Trial
timeFrame: Up to approximately 10 years
measure: Modified Event Free Survival (EFS) Per Evaluation Criteria Used in the Parent Trial
timeFrame: Up to approximately 10 years
measure: Number of Participants Who Experience Serious Adverse Events (SAEs)
timeFrame: Up to approximately 42 months (Up to 90 days after last dose of study treatment)
measure: Number of Participants Who Experience Adverse Events of Special Interest (AEOSI)
timeFrame: Up to approximately 40 months (Up to 30 days after last dose of study treatment)
measure: Number of Participants Who Experience Clinically Significant Adverse Events (CSAE)
timeFrame: Up to approximately 40 months (Up to 30 days after last dose of study treatment)
measure: Number of Participants Who Experience Events of Clinical Interest (ECI)
timeFrame: Up to approximately 40 months (Up to 30 days after last dose of study treatment)
measure: Number of Participants Who Discontinue Study Treatment Due to an AE
timeFrame: Up to approximately 39 months
Other outcomes:
Locations:
city: Tucson
country: United States
facility: Arizona Cancer Center at UMC North ( Site 0018)
state: Arizona
city: Bakersfield
country: United States
facility: Comprehensive Blood & Cancer Center [Bakersfield, CA] ( Site 0054)
state: California
city: Fresno
country: United States
facility: California Cancer Associates for Research & Excellence ( Site 0016)
state: California
city: Fullerton
country: United States
facility: Providence Medical Foundation ( Site 0087)
state: California
city: Los Angeles
country: United States
facility: The Angeles Clinic and Research Institute ( Site 0005)
state: California
city: Los Angeles
country: United States
facility: UCLA Hematology/Oncology - Westwood (Building 100) ( Site 0009)
state: California
city: Orange
country: United States
facility: University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0076)
state: California
city: San Francisco
country: United States
facility: UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0004)
state: California
city: Santa Monica
country: United States
facility: Providence Saint John's Health Center ( Site 0059)
state: California
city: Stanford
country: United States
facility: Stanford Cancer Center ( Site 0086)
state: California
city: Aurora
country: United States
facility: University of Colorado Cancer Center ( Site 0021)
state: Colorado
city: New Haven
country: United States
facility: Yale Cancer Center ( Site 0014)
state: Connecticut
city: Washington
country: United States
facility: Georgetown University Medical Center ( Site 0023)
state: District of Columbia
city: Fort Lauderdale
country: United States
facility: Holy Cross Hospital, Michael & Dianne Bienes Comp Cancer Ctr ( Site 0022)
state: Florida
city: Jacksonville
country: United States
facility: Baptist MD Anderson Cancer Center ( Site 0083)
state: Florida
city: Miami Beach
country: United States
facility: Mount Sinai Medical Center Comprehensive Cancer Center ( Site 0031)
state: Florida
city: Tampa
country: United States
facility: Moffitt Cancer Center ( Site 0011)
state: Florida
city: Atlanta
country: United States
facility: Emory School of Medicine ( Site 0013)
state: Georgia
city: Augusta
country: United States
facility: Augusta University ( Site 0077)
state: Georgia
city: Marietta
country: United States
facility: Northwest Georgia Oncology Centers PC ( Site 0061)
state: Georgia
city: Honolulu
country: United States
facility: Kaiser Permanente Moanalua Medical Center ( Site 0063)
state: Hawaii
city: Chicago
country: United States
facility: The University of Chicago ( Site 0020)
state: Illinois
city: Iowa City
country: United States
facility: University of Iowa Hospital and Clinics ( Site 0026)
state: Iowa
city: Louisville
country: United States
facility: James Graham Brown Cancer Center ( Site 0058)
state: Kentucky
city: Paducah
country: United States
facility: Mercy Health-Paducah Cancer Center ( Site 0084)
state: Kentucky
city: Covington
country: United States
facility: Women's Cancer Care ( Site 0088)
state: Louisiana
city: Baltimore
country: United States
facility: MedStar Franklin Square Medical Center ( Site 0046)
state: Maryland
city: Baltimore
country: United States
facility: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 0056)
state: Maryland
city: Columbia
country: United States
facility: Maryland Oncology Hematology (MOH) ( Site 8000)
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital ( Site 0041)
state: Massachusetts
city: Boston
country: United States
facility: Dana-Farber Cancer Institute ( Site 0006)
state: Massachusetts
city: Detroit
country: United States
facility: Karmanos Cancer Institute ( Site 0047)
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic in Rochester, Minnesota ( Site 0002)
state: Minnesota
city: Las Vegas
country: United States
facility: Comprehensive Cancer Centers of Nevada ( Site 0043)
state: Nevada
city: Hackensack
country: United States
facility: John Theurer Cancer Center at Hackensack University Medical Center ( Site 0038)
state: New Jersey
city: New Brunswick
country: United States
facility: Cancer Institute of New Jersey ( Site 0025)
state: New Jersey
city: New York
country: United States
facility: Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0032)
state: New York
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center ( Site 0012)
state: New York
city: White Plains
country: United States
facility: White Plains Hospital-Center for Cancer Care ( Site 0069)
state: New York
city: Cary
country: United States
facility: WakeMed Cancer Care - Waverly Hematology & Medical Oncology ( Site 0074)
state: North Carolina
city: Chapel Hill
country: United States
facility: University of North Carolina at Chapel Hill ( Site 0040)
state: North Carolina
city: Charlotte
country: United States
facility: Levine Cancer Institute ( Site 0034)
state: North Carolina
city: Durham
country: United States
facility: Duke Cancer Center ( Site 0028)
state: North Carolina
city: Fargo
country: United States
facility: Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0065)
state: North Dakota
city: Cleveland
country: United States
facility: University Hospitals ( Site 0044)
state: Ohio
city: Tulsa
country: United States
facility: Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0082)
state: Oklahoma
city: Portland
country: United States
facility: Providence Portland Medical Center ( Site 0051)
state: Oregon
city: Bethlehem
country: United States
facility: St. Luke's University Health Network ( Site 0017)
state: Pennsylvania
city: Philadelphia
country: United States
facility: University of Pennsylvania ( Site 0010)
state: Pennsylvania
city: Philadelphia
country: United States
facility: Fox Chase Cancer Center ( Site 0042)
state: Pennsylvania
city: Pittsburgh
country: United States
facility: UPMC Hillman Cancer Center ( Site 0008)
state: Pennsylvania
city: Sioux Falls
country: United States
facility: Sanford Cancer Center ( Site 0066)
state: South Dakota
city: Germantown
country: United States
facility: West Cancer Center and Research Institute ( Site 0055)
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt Health One Hundred Oaks Diagnostic ( Site 0060)
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt Ingram Cancer Center ( Site 0015)
state: Tennessee
city: Austin
country: United States
facility: Texas Oncology - Central/South Texas ( Site 8001)
state: Texas
city: Dallas
country: United States
facility: Texas Oncology-Baylor Sammons Cancer Center ( Site 0062)
state: Texas
city: Houston
country: United States
facility: University of Texas MD Anderson Cancer Center ( Site 0007)
state: Texas
city: San Antonio
country: United States
facility: South Texas Accelerated Research Therapeutics, LLC (START) ( Site 0001)
state: Texas
city: Charlottesville
country: United States
facility: University of Virginia Health System ( Site 0035)
state: Virginia
city: Midlothian
country: United States
facility: Bon Secours St. Francis Medical Center-Oncology Research ( Site 0075)
state: Virginia
city: Richmond
country: United States
facility: VCU Health Adult Outpatient Pavillion ( Site 0080)
state: Virginia
city: Roanoke
country: United States
facility: Blue Ridge Cancer Care ( Site 0067)
state: Virginia
city: Seattle
country: United States
facility: Fred Hutchinson Cancer Center ( Site 0024)
state: Washington
city: Berazategui
country: Argentina
facility: Centro de Oncología e Investigación de Buenos Aires ( Site 1357)
state: Buenos Aires
city: Caba
country: Argentina
facility: Fundacion Favaloro ( Site 1367)
state: Buenos Aires
city: Ciudad Autónoma de Buenos Aires
country: Argentina
facility: Instituto Alexander Fleming ( Site 1364)
state: Buenos Aires
city: Ciudad de Buenos Aires
country: Argentina
facility: IDIM - Instituto de Investigaciones Metabólicas ( Site 1362)
state: Buenos Aires
city: Mar del Plata
country: Argentina
facility: Instituto de Investigaciones Clínicas Mar del Plata ( Site 1363)
state: Buenos Aires
city: Viedma
country: Argentina
facility: Clinica Viedma ( Site 1353)
state: Rio Negro
city: Rosario
country: Argentina
facility: Sanatorio Parque ( Site 1355)
state: Santa Fe
city: Rosario
country: Argentina
facility: Instituto de Oncologia de Rosario ( Site 1350)
state: Santa Fe
city: Rosario
country: Argentina
facility: Hospital Provincial del Centenario ( Site 1359)
state: Santa Fe
city: Buenos Aires
country: Argentina
facility: Hospital Aleman-Oncology ( Site 1351)
city: Cordoba
country: Argentina
facility: Hospital Privado Universitario de Córdoba ( Site 1354)
city: La Rioja
country: Argentina
facility: Fundación CORI para la Investigación y Prevención del Cáncer ( Site 1358)
city: San Juan
country: Argentina
facility: Instituto San Marcos ( Site 1366)
city: Tucuman
country: Argentina
facility: Centro Medico San Roque-Oncology ( Site 1352)
city: Camperdown
country: Australia
facility: Chris OBrien Lifehouse ( Site 3003)
state: New South Wales
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital-A.W. Morrow Gastroenterology and Liver Centre ( Site 3016)
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital-Medical Oncology ( Site 3021)
state: New South Wales
city: Macquarie University
country: Australia
facility: Macquarie University ( Site 3010)
state: New South Wales
city: North Sydney
country: Australia
facility: Mater Hospital Sydney ( Site 3007)
state: New South Wales
city: Orange
country: Australia
facility: Orange Hospital-Clinical Trials Unit ( Site 3027)
state: New South Wales
city: Port Macquarie
country: Australia
facility: Port Macquarie - Mid North Coast Cancer Institute-Medical Oncology ( Site 3020)
state: New South Wales
city: St Leonards
country: Australia
facility: Royal North Shore Hospital-Medical Oncology Clinical Trials ( Site 3025)
state: New South Wales
city: Waratah
country: Australia
facility: Calvary Mater Newcastle ( Site 3005)
state: New South Wales
city: Westmead
country: Australia
facility: Westmead Hospital ( Site 3000)
state: New South Wales
city: Wollstonecraft
country: Australia
facility: Melanoma Institute Australia ( Site 3001)
state: New South Wales
city: Brisbane
country: Australia
facility: Mater Misericordiae Limited-Medical Oncology ( Site 3019)
state: Queensland
city: Brisbane
country: Australia
facility: Gallipoli Medical Research Ltd ( Site 3011)
state: Queensland
city: Herston
country: Australia
facility: Royal Brisbane and Women's Hospital ( Site 3009)
state: Queensland
city: Southport
country: Australia
facility: Tasman Oncology Research Pty Ltd ( Site 3012)
state: Queensland
city: Townsville
country: Australia
facility: The Townsville Hospital ( Site 3017)
state: Queensland
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital ( Site 3002)
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital ( Site 3014)
state: South Australia
city: Woodville
country: Australia
facility: The Queen Elizabeth Hospital ( Site 3026)
state: South Australia
city: Clayton
country: Australia
facility: Monash Health ( Site 3015)
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Health-Austin Hospital ( Site 3004)
state: Victoria
city: Melbourne
country: Australia
facility: Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 3008)
state: Victoria
city: Melbourne
country: Australia
facility: St Vincent's Hospital-Oncology Clinical Trials ( Site 3018)
state: Victoria
city: St Albans
country: Australia
facility: Western Health-Sunshine & Footscray Hospitals ( Site 3023)
state: Victoria
city: Wendouree
country: Australia
facility: Ballarat Oncology & Haematology Services ( Site 3022)
state: Victoria
city: Nedlands
country: Australia
facility: Sir Charles Gairdner Hospital ( Site 3006)
state: Western Australia
city: Subiaco
country: Australia
facility: St John of God Subiaco Hospital ( Site 3013)
state: Western Australia
city: Linz
country: Austria
facility: Kepler Universitätsklinikum ( Site 2955)
state: Oberosterreich
city: Graz
country: Austria
facility: Medical University of Graz ( Site 2952)
state: Steiermark
city: Innsbruck
country: Austria
facility: Medizinische Universitaet Innsbruck ( Site 2951)
state: Tirol
city: Salzburg
country: Austria
facility: Uniklinikum Salzburg ( Site 2956)
city: Wien
country: Austria
facility: Medizinische Universität Wien ( Site 2953)
city: Wien
country: Austria
facility: Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2954)
city: Mechelen
country: Belgium
facility: AZ Sint-Maarten ( Site 2904)
state: Antwerpen
city: Anderlecht
country: Belgium
facility: Institut Jules Bordet ( Site 2903)
state: Bruxelles-Capitale, Region De
city: Brussels
country: Belgium
facility: UZ Brussel ( Site 2900)
state: Bruxelles-Capitale, Region De
city: Brussels
country: Belgium
facility: Cliniques universitaires Saint-Luc-Medical Oncology ( Site 2911)
state: Bruxelles-Capitale, Region De
city: Bruxelles
country: Belgium
facility: Cliniques Universitaires de Bruxelles - CUB - Hopital Erasme ( Site 2905)
state: Bruxelles-Capitale, Region De
city: Gent
country: Belgium
facility: AZ Maria Middelares ( Site 2908)
state: Oost-Vlaanderen
city: Leuven
country: Belgium
facility: UZ Leuven ( Site 2901)
state: Vlaams-Brabant
city: Leuven
country: Belgium
facility: UZ Leuven - Campus Gasthuisberg ( Site 2906)
state: Vlaams-Brabant
city: Leuven
country: Belgium
facility: UZ Leuven Gasthuisberg, Gynaecologie-Verloskunde ( Site 2907)
state: Vlaams-Brabant
city: Namur
country: Belgium
facility: Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi ( Site 2909)
city: Fortaleza
country: Brazil
facility: Hospital São Carlos-Oncocentro Ce ( Site 1029)
state: Ceara
city: Fortaleza
country: Brazil
facility: CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA-Pesquisa Clínica ( Site 1024)
state: Ceara
city: Fortaleza
country: Brazil
facility: Centro de Pesquisa Clínica do Instituto do Câncer do Ceará ( Site 1016)
state: Ceara
city: Ijui
country: Brazil
facility: ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 1008)
state: Rio Grande Do Sul
city: Passo Fundo
country: Brazil
facility: Hospital de Clínicas de Passo Fundo ( Site 1025)
state: Rio Grande Do Sul
city: Pelotas
country: Brazil
facility: Lacks - Oncologia E Hematologia ( Site 1026)
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre ( Site 1000)
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital São Lucas da PUCRS-Centro de Pesquisa em Oncologia ( Site 1006)
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Nossa Senhora da Conceição ( Site 1011)
state: Rio Grande Do Sul
city: Santa Maria
country: Brazil
facility: Clinica Viver ( Site 1021)
state: Rio Grande Do Sul
city: Florianópolis
country: Brazil
facility: CEPON ( Site 1012)
state: Santa Catarina
city: Barretos
country: Brazil
facility: Fundação Pio XII - Hospital de Câncer de Barretos ( Site 1010)
state: Sao Paulo
city: Jaú
country: Brazil
facility: Hospital Amaral Carvalho ( Site 1023)
state: Sao Paulo
city: São José do Rio Preto
country: Brazil
facility: Fundação Faculdade Regional de Medicina de São José do Rio Preto-Centro Integrado de Pesquisa ( Site 1003)
state: Sao Paulo
city: São Paulo
country: Brazil
facility: Clínica de Pesquisa e Centro de Estudos em Ginecologia Oncológica e Mamária LTDA ( Site 1017)
state: Sao Paulo
city: Rio de Janeiro
country: Brazil
facility: Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA ( Site 1020)
city: Rio de Janeiro
country: Brazil
facility: Instituto de de Educação, pesquisa e Gestão em Saúde ( Site 1014)
city: Sao Paulo
country: Brazil
facility: Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 1001)
city: Sao Paulo
country: Brazil
facility: BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 1030)
city: Sao Paulo
country: Brazil
facility: A. C. Camargo Cancer Center ( Site 1002)
city: Calgary
country: Canada
facility: Arthur J.E. Child Comprehensive Cancer Centre ( Site 2815)
state: Alberta
city: Edmonton
country: Canada
facility: Cross Cancer Institute ( Site 2804)
state: Alberta
city: Winnipeg
country: Canada
facility: CancerCare Manitoba ( Site 2814)
state: Manitoba
city: Hamilton
country: Canada
facility: Hamilton Health Sciences-Juravinski Cancer Centre ( Site 2801)
state: Ontario
city: Kingston
country: Canada
facility: Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 2808)
state: Ontario
city: London
country: Canada
facility: London Regional Cancer Program - LHSC ( Site 2806)
state: Ontario
city: Ottawa
country: Canada
facility: The Ottawa Hospital - General Campus ( Site 2813)
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Research Institute ( Site 2802)
state: Ontario
city: Toronto
country: Canada
facility: Mount Sinai Hospital ( Site 2811)
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Cancer Centre ( Site 2803)
state: Ontario
city: Greenfield Park
country: Canada
facility: Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre-Oncology ( Site 2809)
state: Quebec
city: Laval
country: Canada
facility: Centre Intégré de Santé et de Services Sociaux (CISSS) de La-Centre intégré de cancérologie de Lava ( Site 2810)
state: Quebec
city: Montreal
country: Canada
facility: Centre Hospitalier de l Universite de Montreal - CHUM ( Site 2807)
state: Quebec
city: Montreal
country: Canada
facility: Jewish General Hospital ( Site 2800)
state: Quebec
city: Montreal
country: Canada
facility: McGill University Health Centre ( Site 2818)
state: Quebec
city: Sherbrooke
country: Canada
facility: Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 2812)
state: Quebec
city: Trois-Rivières
country: Canada
facility: Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 2816)
state: Quebec
city: Quebec
country: Canada
facility: Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 2805)
city: Temuco
country: Chile
facility: James Lind Centro de Investigacion del Cancer ( Site 2757)
state: Araucania
city: Santiago
country: Chile
facility: Orlandi Oncologia-Oncology ( Site 2752)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Fundacion Arturo Lopez Perez FALP ( Site 2750)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Oncovida ( Site 2759)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 2751)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Instituto Nacional del Cancer-CR Investigación ( Site 2753)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Bradfordhill-Clinical Area ( Site 2756)
state: Region M. De Santiago
city: Viña del Mar
country: Chile
facility: ONCOCENTRO APYS-ACEREY ( Site 2758)
state: Valparaiso
city: Viña del Mar
country: Chile
facility: Centro de Investigaciones ( Site 2755)
state: Valparaiso
city: Hefei
country: China
facility: Anhui Provincial Hospital-Cancer Chemotherapy Department ( Site 3480)
state: Anhui
city: Hefei
country: China
facility: Anhui Provincil Hospital South District-Respiratory Medicine Dept ( Site 3487)
state: Anhui
city: Beijing
country: China
facility: Beijing Cancer Hospital ( Site 3451)
state: Beijing
city: Beijing
country: China
facility: The Fifth Medical Center Of The Chinese PLA General Hospital (South) ( Site 3465)
state: Beijing
city: Beijing
country: China
facility: Beijing Cancer Hospital ( Site 3499)
state: Beijing
city: Beijing
country: China
facility: Beijing Cancer Hospital ( Site 3500)
state: Beijing
city: Beijing
country: China
facility: Beijing Cancer hospital-Thoracic Cancer Department A ( Site 3454)
state: Beijing
city: Beijing
country: China
facility: Chinese Academy of medical science, Peking Union Medical College Hospital(Dongdan) ( Site 3466)
state: Beijing
city: Chongqing
country: China
facility: Army Medical Center of People's Liberation Army-Oncology Department ( Site 3477)
state: Chongqing
city: Fuzhou
country: China
facility: Fujian Provincial Cancer Hospital ( Site 3461)
state: Fujian
city: Guanghzou
country: China
facility: Southern medical university Nangfang Hospital ( Site 3490)
state: Guangdong
city: Guangzhou
country: China
facility: The Sixth Affiliated Hospital of Sun Yat-sen University ( Site 3491)
state: Guangdong
city: Guangzhou
country: China
facility: SUN YAT-SEN UNIVERSITY CANCER CENTRE-Internal Medicine ( Site 3452)
state: Guangdong
city: Guangzhou
country: China
facility: Sun Yat-sen University Cancer Center-melanoma ( Site 3482)
state: Guangdong
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital-Cancer Center ( Site 3462)
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital, Sun Yat-sen University-pneumology department ( Site 3459)
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou Medical University-thoracic surgery department ( Site 3460)
state: Guangdong
city: Guiyang
country: China
facility: The Affiliated Cancer Hospital of Guizhou Medical University ( Site 3498)
state: Guizhou
city: Harbin
country: China
facility: Harbin Medical University Cancer Hospital ( Site 3506)
state: Heilongjiang
city: Harbin
country: China
facility: Harbin Medical University Cancer Hospital-Harbin Medical University Cancer Hospital ( Site 3475)
state: Heilongjiang
city: Zhengzhou
country: China
facility: Henan Cancer Hospital ( Site 3488)
state: Henan
city: Wuhan
country: China
facility: Tongji Hospital Tongji Medical,Science & Technology-oncology ( Site 3476)
state: Hubei
city: Wuhan
country: China
facility: Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 3492)
state: Hubei
city: Changsha
country: China
facility: Xiangya Hospital Central South University-Gynecology ( Site 3497)
state: Hunan
city: Changsha
country: China
facility: Xiangya Hospital Central South University-Respiratory ( Site 3479)
state: Hunan
city: Changsha
country: China
facility: Hunan Cancer Hospital ( Site 3485)
state: Hunan
city: Changsha
country: China
facility: Hunan Cancer Hospital ( Site 3501)
state: Hunan
city: Nanjing
country: China
facility: Jiangsu Cancer Hospital-Medical Oncotherapy ( Site 3469)
state: Jiangsu
city: Yancheng
country: China
facility: Yancheng First People s Hospital ( Site 3504)
state: Jiangsu
city: Yangzhou
country: China
facility: Northern Jiangsu People's Hospital-General Surgery Department ( Site 3474)
state: Jiangsu
city: Changchun
country: China
facility: The First Hospital of Jilin University-Oncology ( Site 3464)
state: Jilin
city: Changchun
country: China
facility: Jilin Province Tumor Hospital ( Site 3484)
state: Jilin
city: Xi'an
country: China
facility: Tangdu Hospital of Fourth Military Medical University of Chi-department of radiotherapy ( Site 3455)
state: Shaanxi
city: Shanghai
country: China
facility: Fudan University Shanghai Cancer Center ( Site 3467)
state: Shanghai
city: Shanghai
country: China
facility: Zhongshan Hospital of Fudan University ( Site 3503)
state: Shanghai
city: Shanghai
country: China
facility: Obstetrics & Gynecology Hospital of Fudan University ( Site 3494)
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Pulmonary Hospital ( Site 3470)
state: Shanghai
city: XiAn
country: China
facility: The First Affiliated Hospital of Xi an Jiaotong University ( Site 3489)
state: Shanxi
city: Cheng Du
country: China
facility: West China Hospital Sichuan University-respiratory ( Site 3473)
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University Cancer Institute and Hospital ( Site 3456)
state: Tianjin
city: Urumqi
country: China
facility: Xinjiang Medical University Cancer Hospital - Urumqi-galactophore department ( Site 3486)
state: Xinjiang
city: Urumqi
country: China
facility: The Affiliated Cancer Hospital of Xinjiang Medical University ( Site 3502)
state: Xinjiang
city: Hangzhou
country: China
facility: Women s Hospital School of Medicine Zhejiang University ( Site 3493)
state: Zhejiang
city: Hangzhou
country: China
facility: Hangzhou Cancer Hospital-Medical Oncology ( Site 3468)
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital ( Site 3495)
state: Zhejiang
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital ( Site 3505)
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital ( Site 3481)
state: Zhejiang
city: Medellín
country: Colombia
facility: Instituto de Cancerología-Oncology ( Site 2702)
state: Antioquia
city: Medellín
country: Colombia
facility: Fundacion Colombiana de Cancerología Clinica Vida ( Site 2707)
state: Antioquia
city: Barranquilla
country: Colombia
facility: Clinica de la Costa S.A.S. ( Site 2705)
state: Atlantico
city: Valledupar
country: Colombia
facility: Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 2704)
state: Cesar
city: Montería
country: Colombia
facility: IMAT S.A.S ( Site 2703)
state: Cordoba
city: Bogota
country: Colombia
facility: Instituto Nacional De Cancerologia-Oncología Clínica ( Site 2706)
state: Cundinamarca
city: Bogota
country: Colombia
facility: Administradora Country S.A. ( Site 2701)
state: Distrito Capital De Bogota
city: Cali
country: Colombia
facility: Fundación Valle del Lili ( Site 2700)
state: Valle Del Cauca
city: Cali
country: Colombia
facility: Clínica Imbanaco S.A.S ( Site 2708)
state: Valle Del Cauca
city: San Jose
country: Costa Rica
facility: CIMCA ( Site 3900)
city: Brno
country: Czechia
facility: Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0703)
state: Brno-mesto
city: Olomouc
country: Czechia
facility: Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0704)
state: Olomoucky Kraj
city: Prague
country: Czechia
facility: Fakultni Thomayerova nemocnice-Onkologicka klinika 1. LF UK ( Site 0702)
state: Praha 4
city: Praha
country: Czechia
facility: Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0705)
state: Praha 5
city: Olomouc
country: Czechia
facility: Fakultni nemocnice Olomouc ( Site 0701)
city: Praha 5
country: Czechia
facility: Fakultni nemocnice v Motole ( Site 0700)
city: Odense
country: Denmark
facility: Odense Universitetshospital ( Site 0650)
state: Syddanmark
city: Vejle
country: Denmark
facility: Vejle Sygehus ( Site 0653)
state: Syddanmark
city: Tartu
country: Estonia
facility: Tartu University Hospital-Radiotherapy and oncology ( Site 3800)
state: Tartumaa
city: Tampere
country: Finland
facility: Tampere University Hospital [Tampere Finland] ( Site 0600)
state: Pirkanmaa
city: Turku
country: Finland
facility: Turku University Hospital ( Site 0601)
state: Varsinais-Suomi
city: Nice
country: France
facility: Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Dermatology Department ( Site 2539)
state: Alpes-Maritimes
city: Strasbourg
country: France
facility: Nouvel Hôpital Civil (NHC) ( Site 2529)
state: Alsace
city: Pessac
country: France
facility: CHU Bordeaux Haut-Leveque ( Site 2534)
state: Aquitaine
city: Lyon
country: France
facility: Centre Hopitalar Leon-Berard ( Site 2519)
state: Auvergne
city: Marseille
country: France
facility: Hopital Nord ( Site 2516)
state: Bouches-du-Rhone
city: Marseille
country: France
facility: Hôpital Privé Clairval ( Site 2549)
state: Bouches-du-Rhone
city: Marseille
country: France
facility: CHU La Timone ( Site 2508)
state: Bouches-du-Rhone
city: Dijon
country: France
facility: Centre Georges François Leclerc-Centre de recherche clinique ( Site 2536)
state: Cote-d Or
city: Besancon
country: France
facility: CHU Jean Minjoz ( Site 2520)
state: Doubs
city: Besançon
country: France
facility: CHU-Jean Minjoz ( Site 2550)
state: Doubs
city: Brest
country: France
facility: CHRU Brest - Hopital Cavale Blanche ( Site 2504)
state: Finistere
city: Bordeaux
country: France
facility: Institut Bergonie ( Site 2502)
state: Gironde
city: Toulouse
country: France
facility: CHU Toulouse - Hopital Rangueil ( Site 2518)
state: Haute-Garonne
city: Toulouse
country: France
facility: CHU de Toulouse - Hopital Larrey-service de pneumologie ( Site 2526)
state: Haute-Garonne
city: Boulogne
country: France
facility: Ambroise Pare Hopital ( Site 2503)
state: Hauts-de-Seine
city: Suresnes
country: France
facility: Hôpital Foch ( Site 2543)
state: Hauts-de-Seine
city: Clichy
country: France
facility: Hôpital Beaujon ( Site 2524)
state: Ile-de-France
city: Paris
country: France
facility: Groupe hospitalier Paris saint Joseph-Service de Pneumologie-Allergologie -Oncologie Thoracique ( Site 2533)
state: Ile-de-France
city: Villejuif
country: France
facility: Institut Gustave Roussy ( Site 2513)
state: Ile-de-France
city: Rennes
country: France
facility: Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 2525)
state: Ille-et-Vilaine
city: Chambray-les-Tours
country: France
facility: Hopital Trousseau ( Site 2512)
state: Indre-et-Loire
city: Tours
country: France
facility: C.H.U. de Tours - Hopital Bretonneau ( Site 2515)
state: Indre-et-Loire
city: Saint Herblain
country: France
facility: Institut de Cancérologie de l'Ouest-Oncologie Médicale ( Site 2522)
state: Loire-Atlantique
city: Saint-Herblain
country: France
facility: Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes-lung oncology ( Site 2546)
state: Loire-Atlantique
city: Vandoeuvre-lès-Nancy
country: France
facility: Institut de Cancérologie de Lorraine Alexis Vautrin ( Site 2532)
state: Lorraine
city: Lille
country: France
facility: Centre Oscar Lambret ( Site 2551)
state: Nord-Pas-de-Calais
city: Lille
country: France
facility: CHRU Lille Hospital Claude Huriez ( Site 2506)
state: Nord
city: Clermont-Ferrand
country: France
facility: Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 2542)
state: Puy-de-Dome
city: Pierre Benite
country: France
facility: CH Lyon Sud Hospices Civils de Lyon ( Site 2521)
state: Rhone-Alpes
city: Pierre Benite
country: France
facility: C.H.U. Pontchaillou ( Site 2511)
state: Rhone
city: Le Mans
country: France
facility: Centre Hospitalier du Mans-Pneumologie ( Site 2527)
state: Sarthe
city: Rouen
country: France
facility: Centre Henri Becquerel ( Site 2547)
state: Seine-Maritime
city: Bobigny
country: France
facility: Hôpital Avicenne-Dermatologie ( Site 2538)
state: Seine-Saint-Denis
city: Amiens
country: France
facility: Clinique de L'Europe ( Site 2548)
state: Somme
city: Creteil
country: France
facility: Centre Hopitalier Intercommunal Creteil ( Site 2514)
state: Val-de-Marne
city: Villejuif
country: France
facility: Hôpital Universitaire Paul Brousse ( Site 2541)
state: Val-de-Marne
city: Poitiers
country: France
facility: Centre Hospitalier Universitaire de Poitiers-Dermatologie ( Site 2544)
state: Vienne
city: Paris
country: France
facility: Hopital Cochin ( Site 2509)
city: Paris
country: France
facility: Hopital Saint Louis ( Site 2510)
city: Paris
country: France
facility: CHU Hopital Saint Antoine ( Site 2517)
city: Paris
country: France
facility: Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 2545)
city: Paris
country: France
facility: Hôpital Tenon ( Site 2530)
city: Tuebingen
country: Germany
facility: Universitaetsklinikum Tuebingen ( Site 2405)
state: Baden-Wurttemberg
city: Erlangen
country: Germany
facility: Universitätsklinikum Erlangen ( Site 2408)
state: Bayern
city: Muenchen
country: Germany
facility: Universitaetsklinik Muenchen ( Site 2406)
state: Bayern
city: Frankfurt
country: Germany
facility: Krankenhaus Nordwest ( Site 2409)
state: Hessen
city: Buxtehude
country: Germany
facility: Elbe Klinikum Buxtehude ( Site 2400)
state: Niedersachsen
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover ( Site 2402)
state: Niedersachsen
city: Essen
country: Germany
facility: Universitaetsklinikum Essen ( Site 2404)
state: Nordrhein-Westfalen
city: Homburg
country: Germany
facility: Universitaetsklinikum des Saarlandes-Klinik für Innere Medizin V-Pneumologie, Allergologie, Beatmun ( Site 2411)
state: Saarland
city: Dresden
country: Germany
facility: Universitatsklinikum Carl Gustav Carus ( Site 2407)
state: Sachsen
city: Grosshansdorf
country: Germany
facility: LungenClinic Grosshansdorf GmbH ( Site 2412)
state: Schleswig-Holstein
city: Gera
country: Germany
facility: SRH Wald-Klinikum Gera GmbH ( Site 2403)
state: Thuringen
city: Berlin
country: Germany
facility: Helios Klinikum Emil von Behring Berlin-Zehlendorf-Lungenklinik Heckeshorn ( Site 2418)
city: Hamburg
country: Germany
facility: Facharztzentrum Eppendorf ( Site 2415)
city: Athens
country: Greece
facility: General Hospital of Athens "Laiko"-Hematology Department ( Site 1851)
state: Attiki
city: Athens
country: Greece
facility: Sotiria Regional Chest Diseases Hospital of Athens ( Site 1850)
state: Attiki
city: Guatemala
country: Guatemala
facility: MEDI-K ( Site 3403)
city: Guatemala
country: Guatemala
facility: Oncomedica ( Site 3401)
city: Guatemala
country: Guatemala
facility: Grupo Medico Angeles ( Site 3402)
city: Hksar
country: Hong Kong
facility: Queen Mary Hospital ( Site 1902)
city: Hksar
country: Hong Kong
facility: Queen Mary Hospital-Department of Medicine (Respiratory) ( Site 1900)
city: Hong Kong
country: Hong Kong
facility: Princess Margaret Hospital ( Site 1903)
city: Gyula
country: Hungary
facility: Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Megyei Onkológiai Centrum ( Site 1405)
state: Bekes
city: Miskolc
country: Hungary
facility: Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház ( Site 1409)
state: Borsod-Abauj-Zemplen
city: Székesfehérvár
country: Hungary
facility: Fejér Megyei Szent György Egyetemi Oktató Kórház-l.Pulmonologia ( Site 1407)
state: Fejer
city: Szolnok
country: Hungary
facility: Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 1401)
state: Jasz-Nagykun-Szolnok
city: Budapest
country: Hungary
facility: Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 1411)
state: Pest
city: Szombathely
country: Hungary
facility: Markusovszky Egyetemi Oktatokorhaz-Onkológiai Osztály ( Site 1410)
state: Vas
city: Farkasgyepu
country: Hungary
facility: Farkasgyepui Tudogyogyintezet-Pulmonologia ( Site 1414)
state: Veszprem
city: Budapest
country: Hungary
facility: Semmelweis University-Belgyógyászati és Hematológiai Klinika ( Site 1406)
city: Budapest
country: Hungary
facility: Orszagos Koranyi Pulmonologiai Intezet ( Site 1403)
city: Budapest
country: Hungary
facility: Uzsoki Utcai Kórház-Onkoradiológiai Osztály ( Site 1413)
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Haematologia) ( Site 1415)
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 1412)
city: Kaposvar
country: Hungary
facility: Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 1402)
city: Zalaegerszeg
country: Hungary
facility: Zala Megyei Szent Rafael Korhaz ( Site 1400)
city: Dublin
country: Ireland
facility: Mater Misercordiae University Hospital ( Site 1800)
state: Leinster
city: Dublin
country: Ireland
facility: Tallaght University Hospital ( Site 1803)
city: Dublin
country: Ireland
facility: St. James s Hospital ( Site 1801)
city: Haifa
country: Israel
facility: Rambam Health Care Campus-Oncology Division ( Site 2053)
city: Haifa
country: Israel
facility: Bnai Zion Medical Center ( Site 2060)
city: Jerusalem
country: Israel
facility: Hadassah Ein Kerem Medical Center ( Site 2051)
city: Petah-Tikva
country: Israel
facility: Rabin Medical Center ( Site 2059)
city: Ramat Gan
country: Israel
facility: Chaim Sheba Medical Center. ( Site 2052)
city: Ramat Gan
country: Israel
facility: Chaim Sheba Medical Center ( Site 2055)
city: Ramat Gan
country: Israel
facility: Sheba Medical Center ( Site 2062)
city: Ramat Gan
country: Israel
facility: Sheba Medical Center ( Site 2065)
city: Safed
country: Israel
facility: ZIV Medical Center-Hematology Institute ( Site 2061)
city: Tel Aviv
country: Israel
facility: Sourasky Medical Center ( Site 2054)
city: Zerifin
country: Israel
facility: Shamir Medical Center Assaf Harofeh ( Site 2058)
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1978)
state: Emilia-Romagna
city: Roma
country: Italy
facility: Istittuto Nazionale dei Tumori Regina Elena IRCCS - IFO ( Site 1963)
state: Lazio
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1975)
state: Lazio
city: Milan
country: Italy
facility: Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1977)
state: Lombardia
city: Monza
country: Italy
facility: Azienda Ospedaliera San Gerardo ( Site 1980)
state: Lombardia
city: Rozzano
country: Italy
facility: Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1968)
state: Milano
city: Aviano
country: Italy
facility: IRCCS CRO Aviano, Hematology/Oncology ( Site 1957)
state: Pordenone
city: Catania
country: Italy
facility: Ospedale Cannizzaro ( Site 1981)
state: Sicilia
city: Candiolo
country: Italy
facility: Istituto di Candiolo - IRCCS ( Site 1960)
state: Torino
city: Orbassano
country: Italy
facility: Ospedale San Luigi Gonzaga ( Site 1956)
state: Torino
city: Perugia
country: Italy
facility: AO Santa Maria della Misericordia-Oncology Department ( Site 1971)
state: Umbria
city: Padova
country: Italy
facility: Istituto Oncologico Veneto IRCCS ( Site 1976)
state: Veneto
city: Bergamo
country: Italy
facility: Humanitas Gavazzeni ( Site 1954)
city: Bergamo
country: Italy
facility: Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-UOC Oncologia ( Site 1967)
city: Brescia
country: Italy
facility: Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 1972)
city: Genova
country: Italy
facility: IRCCS A.O.U. San Martino - IST ( Site 1961)
city: Milano
country: Italy
facility: Ospedale San Raffaele. ( Site 1979)
city: Milano
country: Italy
facility: Istituto Europeo di Oncologia ( Site 1952)
city: Napoli
country: Italy
facility: Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1955)
city: Parma
country: Italy
facility: Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 1964)
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico San Matteo ( Site 1982)
city: Roma
country: Italy
facility: Azienda Ospedaliera San Camillo Forlanini ( Site 1958)
city: Roma
country: Italy
facility: Policlinico Universitario Agostino Gemelli ( Site 1965)
city: Siena
country: Italy
facility: ospedale le scotte-U.O.C. Immunoterapia Oncologica ( Site 1969)
city: Terni
country: Italy
facility: Azienda Ospedaliera Santa Maria ( Site 1962)
city: Torino
country: Italy
facility: Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 1974)
city: Nagoya-Shi
country: Japan
facility: Nagoya University Hospital ( Site 3151)
state: Aichi
city: Nagoya
country: Japan
facility: National Hospital Organization Nagoya Medical Center ( Site 3109)
state: Aichi
city: Nagoya
country: Japan
facility: Aichi Cancer Center ( Site 3101)
state: Aichi
city: Kashiwa
country: Japan
facility: National Cancer Center Hospital East ( Site 3121)
state: Chiba
city: Matsuyama
country: Japan
facility: National Hospital Organization Shikoku Cancer Center ( Site 3116)
state: Ehime
city: Toon,
country: Japan
facility: Ehime University Hospital ( Site 3158)
state: Ehime
city: Kurume
country: Japan
facility: Kurume University Hospital ( Site 3105)
state: Fukuoka
city: Sapporo
country: Japan
facility: National Hospital Organization Hokkaido Cancer Center ( Site 3160)
state: Hokkaido
city: Sapporo
country: Japan
facility: Sapporo Kosei General Hospital ( Site 3172)
state: Hokkaido
city: Sapporo
country: Japan
facility: Sapporo Medical University Hospital ( Site 3113)
state: Hokkaido
city: Sapporo
country: Japan
facility: Hokkaido University Hospital ( Site 3165)
state: Hokkaido
city: Akashi
country: Japan
facility: Hyogo Cancer Center ( Site 3131)
state: Hyogo
city: Himeji
country: Japan
facility: National Hospital Organization Himeji Medical Center ( Site 3111)
state: Hyogo
city: Kobe
country: Japan
facility: Kobe City Medical Center General Hospital ( Site 3144)
state: Hyogo
city: Nishinomiya
country: Japan
facility: Hyogo Medical University Hospital ( Site 3100)
state: Hyogo
city: Kasama
country: Japan
facility: Ibaraki Prefectural Central Hospital ( Site 3180)
state: Ibaraki
city: Tsukuba
country: Japan
facility: University of Tsukuba Hospital ( Site 3176)
state: Ibaraki
city: Kanazawa
country: Japan
facility: Kanazawa University Hospital ( Site 3140)
state: Ishikawa
city: Shiwa-gun
country: Japan
facility: Iwate Medical University Hospital ( Site 3157)
state: Iwate
city: Kita
country: Japan
facility: Kagawa University Hospital ( Site 3171)
state: Kagawa
city: Kawasaki
country: Japan
facility: Nippon Medical School Musashi Kosugi Hospital ( Site 3178)
state: Kanagawa
city: Kawasaki
country: Japan
facility: St. Marianna University Hospital ( Site 3182)
state: Kanagawa
city: Sagamihara
country: Japan
facility: Kitasato University Hospital ( Site 3142)
state: Kanagawa
city: Yokohama
country: Japan
facility: Yokohama City University Hospital ( Site 3163)
state: Kanagawa
city: Yokohama
country: Japan
facility: Kanagawa Cancer Center ( Site 3137)
state: Kanagawa
city: Yokosuka
country: Japan
facility: Yokosuka Kyosai Hospital ( Site 3150)
state: Kanagawa
city: Natori
country: Japan
facility: Miyagi Cancer Center ( Site 3122)
state: Miyagi
city: Sendai-shi
country: Japan
facility: Tohoku University Hospital ( Site 3175)
state: Miyagi
city: Sendai
country: Japan
facility: Sendai Kousei Hospital ( Site 3115)
state: Miyagi
city: Kashihara
country: Japan
facility: Nara Medical University Hospital ( Site 3110)
state: Nara
city: Niigata-shi
country: Japan
facility: Niigata Cancer Center Hospital ( Site 3173)
state: Niigata
city: Kurashiki
country: Japan
facility: Kurashiki Central Hospital ( Site 3132)
state: Okayama
city: Ginowan
country: Japan
facility: University of the Ryukyus Hospital ( Site 3155)
state: Okinawa
city: Chuo-ku
country: Japan
facility: Osaka International Cancer Institute ( Site 3129)
state: Osaka
city: Habikino
country: Japan
facility: Osaka Habikino Medical Center ( Site 3138)
state: Osaka
city: Hirakata
country: Japan
facility: Kansai Medical University Hospital ( Site 3126)
state: Osaka
city: Osakasayama
country: Japan
facility: Kindai University Hospital ( Site 3102)
state: Osaka
city: Osakasayama
country: Japan
facility: Kindai University Hospital ( Site 3135)
state: Osaka
city: Sakai
country: Japan
facility: Osaka Rosai Hospital ( Site 3148)
state: Osaka
city: Sayama
country: Japan
facility: Kindai University Hospital ( Site 3166)
state: Osaka
city: Suita
country: Japan
facility: The University of Osaka Hospital ( Site 3168)
state: Osaka
city: Takatsuki
country: Japan
facility: Osaka Medical and Pharmaceutical University Hospital ( Site 3167)
state: Osaka
city: Hidaka
country: Japan
facility: Saitama Medical University International Medical Center ( Site 3118)
state: Saitama
city: Kitaadachi-gun
country: Japan
facility: Saitama Prefectural Cancer Center ( Site 3112)
state: Saitama
city: Koshigaya
country: Japan
facility: Dokkyo Medical University Saitama Medical Center ( Site 3152)
state: Saitama
city: Tokorozawa
country: Japan
facility: National Defense Medical College Hospital ( Site 3177)
state: Saitama
city: Nagaizumi
country: Japan
facility: Shizuoka Cancer Center ( Site 3128)
state: Shizuoka
city: Shimotsuke
country: Japan
facility: Jichi Medical University Hospital ( Site 3141)
state: Tochigi
city: Bunkyō
country: Japan
facility: Institute of Science Tokyo Hospital ( Site 3149)
state: Tokyo
city: Koto
country: Japan
facility: Cancer Institute Hospital of JFCR ( Site 3146)
state: Tokyo
city: Koto
country: Japan
facility: Cancer Institute Hospital of JFCR ( Site 3164)
state: Tokyo
city: Minato-ku
country: Japan
facility: Toranomon Hospital ( Site 3134)
state: Tokyo
city: Minato-ku
country: Japan
facility: Toranomon Hospital ( Site 3153)
state: Tokyo
city: Mitaka-shi
country: Japan
facility: Kyorin University Hospital ( Site 3147)
state: Tokyo
city: Mitaka
country: Japan
facility: Kyorin University Hospital ( Site 3103)
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Medical University Hospital ( Site 3170)
state: Tokyo
city: Ube
country: Japan
facility: National Hospital Organization Yamaguchi Ube Medical Center ( Site 3123)
state: Yamaguchi
city: Ube
country: Japan
facility: Yamaguchi University Hospital ( Site 3114)
state: Yamaguchi
city: Chiba
country: Japan
facility: Chiba Cancer Center ( Site 3117)
city: Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Medical Center ( Site 3136)
city: Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Cancer Center ( Site 3169)
city: Fukuoka
country: Japan
facility: Kyushu University Hospital ( Site 3143)
city: Fukuoka
country: Japan
facility: Kyushu University Hospital ( Site 3185)
city: Gifu
country: Japan
facility: Gifu University Hospital ( Site 3161)
city: Hiroshima
country: Japan
facility: Hiroshima City Hiroshima Citizens Hospital ( Site 3119)
city: Hiroshima
country: Japan
facility: Hiroshima University Hospital ( Site 3154)
city: Kochi
country: Japan
facility: Kochi Health Sciences Center ( Site 3145)
city: Kumamoto
country: Japan
facility: Kumamoto University Hospital ( Site 3179)
city: Kyoto
country: Japan
facility: Kyoto University Hospital ( Site 3181)
city: Niigata
country: Japan
facility: Niigata University Medical & Dental Hospital ( Site 3174)
city: Okayama
country: Japan
facility: Okayama University Hospital ( Site 3107)
city: Osaka
country: Japan
facility: Osaka City General Hospital ( Site 3125)
city: Osaka
country: Japan
facility: National Hospital Organization Osaka National Hospital ( Site 3162)
city: Osaka
country: Japan
facility: Osaka General Medical Center ( Site 3184)
city: Tokyo
country: Japan
facility: National Cancer Center Hospital ( Site 3130)
city: Tokyo
country: Japan
facility: St.Luke's International Hospital ( Site 3120)
city: Tokyo
country: Japan
facility: The Jikei University Hospital ( Site 3156)
city: Tokyo
country: Japan
facility: Nippon Medical School Hospital ( Site 3139)
city: Tokyo
country: Japan
facility: Tokyo Metropolitan Komagome Hospital ( Site 3133)
city: Tokyo
country: Japan
facility: Cancer Institute Hospital of JFCR ( Site 3108)
city: Tokyo
country: Japan
facility: Keio University Hospital ( Site 3127)
city: Tokyo
country: Japan
facility: Teikyo University Hospital ( Site 3104)
city: Toyama
country: Japan
facility: Toyama Prefectural Central Hospital ( Site 3183)
city: Wakayama
country: Japan
facility: Wakayama Medical University Hospital ( Site 3124)
city: Cheongju-si
country: Korea, Republic of
facility: Chungbuk National University Hospital ( Site 0961)
state: Chungbuk
city: Inceon
country: Korea, Republic of
facility: Gachon University Gil Medical Center ( Site 0967)
state: Incheon
city: Hwasun
country: Korea, Republic of
facility: Chonnam National University Hwasun Hospital-Hemato-Oncology ( Site 0959)
state: Jeonranamdo
city: Goyang-si
country: Korea, Republic of
facility: National Cancer Center ( Site 0955)
state: Kyonggi-do
city: Seongnam si
country: Korea, Republic of
facility: CHA Bundang Medical Center CHA University ( Site 0957)
state: Kyonggi-do
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital ( Site 0951)
state: Kyonggi-do
city: Gangnam-gu
country: Korea, Republic of
facility: Gangnam Severance Hospital, Yonsei University Health System ( Site 0966)
state: Seoul
city: Songpagu
country: Korea, Republic of
facility: Asan Medical Center ( Site 0952)
state: Seoul
city: Daegu
country: Korea, Republic of
facility: Keimyung University Dongsan Hospital CRC room 1 ( Site 0960)
state: Taegu-Kwangyokshi
city: Deagu
country: Korea, Republic of
facility: Kyungpook National University Chilgok Hospital ( Site 0964)
state: Taegu-Kwangyokshi
city: Daejeon
country: Korea, Republic of
facility: Chungnam national university hospital-Department of Internal Medicine ( Site 0958)
state: Taejon-Kwangyokshi
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital ( Site 0956)
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital ( Site 0953)
city: Seoul
country: Korea, Republic of
facility: Severance Hospital ( Site 0954)
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System ( Site 0962)
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center ( Site 0950)
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital ( Site 0963)
city: Liepaja
country: Latvia
facility: Liepjas reionl slimnca ( Site 3851)
city: Riga
country: Latvia
facility: RIGA EAST UNIVERSITY HOSPITAL ,Oncology Centre of Latvia-Out-patient and Day patient facility of Ch ( Site 3850)
city: Klaipeda
country: Lithuania
facility: Klaipeda University Hospital-Oncology chemotherapy ( Site 3302)
state: Klaipedos Miestas
city: Vilnius
country: Lithuania
facility: National Cancer Institute-Chemotherapy departament with day care unit ( Site 3301)
state: Vilniaus Miestas
city: Vilnius
country: Lithuania
facility: Vilniaus Universiteto Ligonine Santaros Klinikos ( Site 3300)
city: Kuantan
country: Malaysia
facility: Hospital Tengku Ampuan Afzan ( Site 0627)
state: Pahang
city: Georgetown
country: Malaysia
facility: Gleneagles Penang ( Site 0625)
state: Pulau Pinang
city: Kuala Lumpur
country: Malaysia
facility: Pantai Hospital Kuala Lumpur ( Site 0628)
city: Kuala Lumpur
country: Malaysia
facility: University Malaya Medical Centre ( Site 0626)
city: La Paz
country: Mexico
facility: Investigación Oncofarmacéutica-Investigación clínica ( Site 1114)
state: Baja California Sur
city: Ciudad de Mexico
country: Mexico
facility: INSTITUTO NACIONAL DE CANCEROLOGIA ( Site 1102)
state: Distrito Federal
city: Monterrey
country: Mexico
facility: Avix Investigación Clinica, S.C.-Oncology ( Site 1104)
state: Nuevo Leon
city: Monterrey
country: Mexico
facility: Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Hematologia and Oncologia ( Site 1113)
state: Nuevo Leon
city: San Pedro Garza García
country: Mexico
facility: Centro de Urologa Avanzada del Noreste ( Site 1110)
state: Nuevo Leon
city: Oaxaca de Juarez
country: Mexico
facility: Oaxaca Site Management Organization ( Site 1106)
state: Oaxaca
city: Merida
country: Mexico
facility: Medical Care and Research SA de CV ( Site 1103)
state: Yucatan
city: Mexico City
country: Mexico
facility: Oncare Viaducto Napoles ( Site 1107)
city: Nijmegen
country: Netherlands
facility: Radboud University Medical Center ( Site 1554)
state: Gelderland
city: Amsterdam
country: Netherlands
facility: Antoni van Leeuwenhoek Ziekenhuis ( Site 1551)
state: Noord-Holland
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, locatie VUmc ( Site 1555)
state: Noord-Holland
city: Rotterdam
country: Netherlands
facility: Erasmus MC ( Site 1553)
state: Zuid-Holland
city: Groningen
country: Netherlands
facility: Universitair Medisch Centrum Groningen ( Site 1550)
city: Christchurch
country: New Zealand
facility: Canterbury Regional Cancer & Blood Service ( Site 1500)
state: Canterbury
city: Hamilton
country: New Zealand
facility: Waikato Hospital ( Site 1502)
state: Waikato
city: Auckland
country: New Zealand
facility: Auckland City Hospital ( Site 1503)
city: Wellington
country: New Zealand
facility: Capital & Coast District Health Board - Wellington Hospital ( Site 1501)
city: Bergen
country: Norway
facility: Helse Bergen Haukeland universitetssykehus ( Site 1451)
state: Vestfold
city: Oslo
country: Norway
facility: Oslo Universitetssykehus Radiumhospitalet ( Site 1450)
city: Oslo
country: Norway
facility: Oslo universitetssykehus, Radiumhospitalet ( Site 1452)
city: Lima
country: Peru
facility: IPOR Instituto Peruano de Oncología & Radioterapia ( Site 0678)
city: Lima
country: Peru
facility: INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 0681)
city: Lima
country: Peru
facility: Hospital Cayetano Heredia-Oncology ( Site 0675)
city: Makati
country: Philippines
facility: Makati Medical Center ( Site 1702)
state: National Capital Region
city: Quezon City
country: Philippines
facility: Lung Center of the Philippines ( Site 1705)
state: National Capital Region
city: Quezon City
country: Philippines
facility: St. Luke s Medical Center ( Site 1700)
state: National Capital Region
city: Bydgoszcz
country: Poland
facility: Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1612)
state: Kujawsko-pomorskie
city: Brzeziny
country: Poland
facility: Powiatowe Centrum Zdrowia w Brzezinach Sp. z o. o. Oddział Dziennej Chemioterapii ( Site 1611)
state: Lodzkie
city: Łódź
country: Poland
facility: Instytut Centrum Zdrowia Matki Polki-Klinika Onkologii ( Site 1609)
state: Lodzkie
city: Krakow
country: Poland
facility: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Oddzial w Krakowie ( Site 1608)
state: Malopolskie
city: Kraków
country: Poland
facility: Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1618)
state: Malopolskie
city: Warszawa
country: Poland
facility: Luxmed Onkologia sp. z o. o. ( Site 1621)
state: Mazowieckie
city: Warszawa
country: Poland
facility: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 1604)
state: Mazowieckie
city: Warszawa
country: Poland
facility: Wojskowy Instytut Medyczny-Klinika Onkologii ( Site 1606)
state: Mazowieckie
city: Opole
country: Poland
facility: Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Kosza-Klinika Onkologii z Odcinkiem Dziennym ( Site 1616)
state: Opolskie
city: Bialystok
country: Poland
facility: Bialostockie Centrum Onkologii ( Site 1610)
state: Podlaskie
city: Gliwice
country: Poland
facility: Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1620)
state: Slaskie
city: Konin
country: Poland
facility: Przychodnia Lekarska KOMED ( Site 1603)
state: Wielkopolskie
city: Poznan
country: Poland
facility: Med-Polonia Sp. z o. o. ( Site 1605)
state: Wielkopolskie
city: Poznan
country: Poland
facility: Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu Medycznego im. K. Marcinkowskiego w Pozna ( Site 1601)
state: Wielkopolskie
city: Poznan
country: Poland
facility: Wielkopolskie Centrum Onkologii im.M.Sklodowskiej-Curie ( Site 1619)
state: Wielkopolskie
city: Koszalin
country: Poland
facility: Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 1614)
state: Zachodniopomorskie
city: Lisbon
country: Portugal
facility: Champalimaud Foundation ( Site 1751)
state: Lisboa
city: Lisboa
country: Portugal
facility: Unidade Local de Saude de Santa Maria - Hospital Pulido Valente ( Site 1750)
city: Porto
country: Portugal
facility: Instituto Português de Oncologia do Porto Francisco Gentil, EPE-Oncologia Médica ( Site 1753)
city: Porto
country: Portugal
facility: Centro Hospitalar de Sao Joao - Hospital de Sao Joao ( Site 1752)
city: Ponce
country: Puerto Rico
facility: Ad-Vance Medical Research-Research ( Site 1151)
city: San Juan
country: Puerto Rico
facility: FDI Clinical Research ( Site 1152)
city: San Juan
country: Puerto Rico
facility: UPR Comprehensive Cancer Center ( Site 1150)
city: Suceava
country: Romania
facility: Spitalul Județean Sfântul Ioan cel Nou Suceava-Oncology ( Site 3550)
city: Barnaul
country: Russian Federation
facility: Altai Regional Clinical Oncology Center ( Site 1229)
state: Altayskiy Kray
city: Ufa
country: Russian Federation
facility: Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1204)
state: Baskortostan, Respublika
city: Ufa
country: Russian Federation
facility: Bashkir State Medical University ( Site 1221)
state: Baskortostan, Respublika
city: Belgorod
country: Russian Federation
facility: Belgorod Oncology Dispensary ( Site 1213)
state: Belgorodskaya Oblast
city: Ivanovo
country: Russian Federation
facility: Regional Budgetary Healthcare Institution 'Ivanovo Regional Oncology Dispensary'-Urology ( Site 1219)
state: Ivanovskaya Oblast
city: Saint-Petersburg
country: Russian Federation
facility: GBUZ LOKB ( Site 1218)
state: Leningradskaya Oblast
city: Saint-Petersburg
country: Russian Federation
facility: GBUZ LOKB-Oncology department #1 ( Site 1222)
state: Leningradskaya Oblast
city: Saransk
country: Russian Federation
facility: Ogarev Mordovia State University ( Site 1206)
state: Mordoviya, Respublika
city: Moscow
country: Russian Federation
facility: The National Medico-Surgical Center N.I. Pirogov ( Site 1225)
state: Moskva
city: Moscow
country: Russian Federation
facility: N.N. Blokhin NMRCO ( Site 1209)
state: Moskva
city: Moscow
country: Russian Federation
facility: Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 1201)
state: Moskva
city: Moscow
country: Russian Federation
facility: FSBI-FRCC of Special Types Med. Care and Technologies FMBA of Russia ( Site 1234)
state: Moskva
city: Moscow
country: Russian Federation
facility: Russian Scientific Center of Roentgenoradiology ( Site 1215)
state: Moskva
city: Moscow
country: Russian Federation
facility: P. A. Hertsen Moscow Oncology Research Center ( Site 1214)
state: Moskva
city: Moscow
country: Russian Federation
facility: FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 1208)
state: Moskva
city: Saint Petersburg
country: Russian Federation
facility: Russian Scientific Research Institute of Hematology and Blood Transfusion-Hematology ( Site 1224)
state: Sankt-Peterburg
city: Saint Petersburg
country: Russian Federation
facility: First Pavlov State Medical University of Saint Petersburg ( Site 1232)
state: Sankt-Peterburg
city: Saint Petersburg
country: Russian Federation
facility: Almazov National Medical Research Centre ( Site 1233)
state: Sankt-Peterburg
city: Saint Petersburg
country: Russian Federation
facility: N.N.Petrov Research Institute of Oncology-Department of Preclinical and Clinical Research ( Site 1211)
state: Sankt-Peterburg
city: Saint-Petersburg
country: Russian Federation
facility: Clinical Research Center of specialized types medical care-Oncology ( Site 1205)
state: Sankt-Peterburg
city: St Petersburg
country: Russian Federation
facility: EuroCityClinic ( Site 1230)
state: Sankt-Peterburg
city: St. Petersburg
country: Russian Federation
facility: St. Petersburg Clinical Hospital of Russian Academy Of Sciences ( Site 1235)
state: Sankt-Peterburg
city: St. Petersburg
country: Russian Federation
facility: National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 1210)
state: Sankt-Peterburg
city: Pyatigorsk
country: Russian Federation
facility: GBUZ SK Pyatigorsk Interdistrict Oncology dispensary ( Site 1223)
state: Stavropol Skiy Kray
city: Kazan
country: Russian Federation
facility: Republican Clinical Oncology Dispensary ( Site 1228)
state: Tatarstan, Respublika
city: Kazan
country: Russian Federation
facility: Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 1203)
state: Tatarstan, Respublika
city: Tomsk
country: Russian Federation
facility: Tomsk Scientific Research Institute of Oncology ( Site 1227)
state: Tomskaya Oblast
city: Tyumen
country: Russian Federation
facility: SAIH of the Tyumen region, Multidisciplinary Clinical Medical Center "Medical town" ( Site 1220)
state: Tyumenskaya Oblast
city: Izhevsk
country: Russian Federation
facility: Udmurtian Republican Clinical Oncology Center ( Site 1212)
state: Udmurtskaya Respublika
city: SIngapore
country: Singapore
facility: National Cancer Centre Singapore ( Site 2200)
state: Central Singapore
city: Singapore
country: Singapore
facility: National University Hospital-Haematology -Oncology Research Group ( Site 2201)
state: South West
city: Johannesburg
country: South Africa
facility: WCR Office ( Site 2002)
state: Gauteng
city: Pretoria
country: South Africa
facility: Wilgers Oncology Centre ( Site 2006)
state: Gauteng
city: Pretoria
country: South Africa
facility: LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 2005)
state: Gauteng
city: Sandton
country: South Africa
facility: Sandton Oncology Medical Group (Pty) Ltd-Research ( Site 2004)
state: Gauteng
city: Durban
country: South Africa
facility: The Oncology Centre ( Site 2000)
state: Kwazulu-Natal
city: Cape Town
country: South Africa
facility: Cape Town Oncology Trials ( Site 2007)
state: Western Cape
city: George
country: South Africa
facility: GVI Oncology ( Site 2008)
state: Western Cape
city: Malaga
country: Spain
facility: Hospital Universitario Virgen de la Victoria ( Site 0878)
state: Andalucia
city: Oviedo
country: Spain
facility: Hospital Universitario Central de Asturias-Medical Oncology ( Site 0870)
state: Asturias
city: Palma de Mallorca
country: Spain
facility: Hospital Son Llatzer ( Site 0886)
state: Baleares
city: Palma
country: Spain
facility: Hospital Universitari Son Espases-Oncologia ( Site 0883)
state: Baleares
city: Hospitalet de Llobregat
country: Spain
facility: Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 0860)
state: Barcelona
city: Santander
country: Spain
facility: H. Marques de Valdecilla ( Site 0865)
state: Cantabria
city: Badalona
country: Spain
facility: Institut Catala d Oncologia Hospital Germans Trias i Pujol ( Site 0851)
state: Cataluna
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona ( Site 0852)
state: Cataluna
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau-Oncología Médica ( Site 0862)
state: Cataluna
city: Santiago de Compostela
country: Spain
facility: CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 0876)
state: La Coruna
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Universitario Insular de Gran Canaria ( Site 0867)
state: Las Palmas
city: Madrid
country: Spain
facility: Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 0877)
state: Madrid, Comunidad De
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro-Majadahonda ( Site 0861)
state: Madrid
city: Pozuelo de Alarcon
country: Spain
facility: Hospital Universitario Quiron Madrid ( Site 0868)
state: Madrid
city: Málaga
country: Spain
facility: H.R.U Malaga - Hospital General ( Site 0884)
state: Malaga
city: Reus
country: Spain
facility: Hospital Universitari Sant Joan de Reus-Oncology ( Site 0874)
state: Tarragona
city: Valencia
country: Spain
facility: Instituto Valenciano de Oncologia - IVO ( Site 0863)
state: Valenciana, Comunitat
city: Valencia
country: Spain
facility: Hospital Clinico de Valencia ( Site 0858)
state: Valenciana, Comunitat
city: Valencia
country: Spain
facility: Hospital General Universitario de Valencia ( Site 0854)
state: Valenciana, Comunitat
city: Valencia
country: Spain
facility: Hospital Arnau de Vilanova ( Site 0866)
state: Valenciana, Comunitat
city: València
country: Spain
facility: Hospital Universitari i Politecnic La Fe ( Site 0875)
state: Valencia
city: Alicante
country: Spain
facility: Hospital General Universitario de Alicante-Oncologia ( Site 0881)
city: Barcelona
country: Spain
facility: Parc de Salut Mar - Hospital del Mar-Oncologia ( Site 0873)
city: Barcelona
country: Spain
facility: H.U. Vall de Hebron ( Site 0850)
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia ( Site 0885)
city: Jaen
country: Spain
facility: Complejo Hospitalario de Jaén-Servicio de Oncología Médica ( Site 0879)
city: Madrid
country: Spain
facility: Hospital Universitario Gregorio Maranon ( Site 0864)
city: Madrid
country: Spain
facility: Clinica Universitaria de Navarra ( Site 0855)
city: Madrid
country: Spain
facility: Hospital Clinico San Carlos ( Site 0857)
city: Madrid
country: Spain
facility: Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 0871)
city: Madrid
country: Spain
facility: Hospital General Universitario 12 de Octubre ( Site 0856)
city: Madrid
country: Spain
facility: Hospital Universitario La Paz ( Site 0853)
city: Madrid
country: Spain
facility: Centro Integral Oncologico Clara Campal-Hospital HM Universitario Sanchinarro-START Madrid, ( Site 0869)
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 0880)
city: Sevilla
country: Spain
facility: HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 0872)
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen de Valme-Departamento de Oncologia ( Site 0882)
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa ( Site 0859)
city: Stockholm
country: Sweden
facility: Karolinska Universitetssjukhuset Solna ( Site 0802)
state: Stockholms Lan
city: Uppsala
country: Sweden
facility: Blod och Tumorssjukdomar. Akademiska sjukhuset ( Site 0801)
state: Uppsala Lan
city: Umea
country: Sweden
facility: Norrlands Universitetssjukhus ( Site 0800)
state: Vasterbottens Lan
city: Gothenburg
country: Sweden
facility: Sahlgrenska Universitetssjukhuset-Department of Oncology CTU Clinical Trial Unit ( Site 0803)
state: Vastra Gotalands Lan
city: Basel
country: Switzerland
facility: University Hospital Basel ( Site 0752)
state: Basel-Stadt
city: Genève
country: Switzerland
facility: Hôpitaux Universitaires de Genève (HUG) ( Site 0753)
state: Geneve
city: Zürich-Flughafen
country: Switzerland
facility: Universitaetsspital Zuerich ( Site 0750)
state: Zurich
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital ( Site 3203)
city: Taichung
country: Taiwan
facility: China Medical University Hospital ( Site 3204)
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital ( Site 3201)
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital ( Site 3200)
city: Taipei
country: Taiwan
facility: Mackay Memorial Hospital ( Site 3205)
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital ( Site 3202)
city: Taipei
country: Taiwan
facility: Koo Foundation Sun Yat-Sen Cancer Center-Gynecology, Obstetrics, and women's health ( Site 3207)
city: Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation-Linkou Branch ( Site 3206)
city: Muang
country: Thailand
facility: Faculty of Medicine - Khon Kaen University ( Site 2366)
state: Khon Kaen
city: Bangkok
country: Thailand
facility: Chulalongkorn University ( Site 2363)
state: Krung Thep Maha Nakhon
city: Bangkok
country: Thailand
facility: Ramathibodi Hospital ( Site 2364)
state: Krung Thep Maha Nakhon
city: Bangkok
country: Thailand
facility: Faculty of Medicine Siriraj Hospital ( Site 2365)
state: Krung Thep Maha Nakhon
city: Üsküdar /Istanbul
country: Turkey
facility: Acibadem Altunizade Hospital-Oncology ( Site 1317)
state: Istanbul
city: Adana
country: Turkey
facility: Acibadem Adana Hospital-Pediatric Hematology-Oncology ( Site 1312)
city: Adana
country: Turkey
facility: Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1307)
city: Adana
country: Turkey
facility: Adana Sehir Egitim ve Arastirma Hastanesi ( Site 1324)
city: Ankara
country: Turkey
facility: Ankara University Hospital Cebeci ( Site 1306)
city: Ankara
country: Turkey
facility: Hacettepe Universitesi-oncology hospital ( Site 1304)
city: Ankara
country: Turkey
facility: Gazi University Health Research and Application Center Gazi Hospital ( Site 1325)
city: Ankara
country: Turkey
facility: Ankara City Hospital-Medical Oncology ( Site 1311)
city: Ankara
country: Turkey
facility: Baskent Universitesi Ankara Hastanesi ( Site 1303)
city: Antalya
country: Turkey
facility: Akdeniz Universitesi Hastanesi-Medical Onkology ( Site 1318)
city: Antalya
country: Turkey
facility: Memorial Antalya Hospital-Oncology ( Site 1315)
city: Edirne
country: Turkey
facility: Trakya Universitesi Tip Fakultesi ( Site 1301)
city: Istanbul
country: Turkey
facility: Bezmialem Vakf Üniversitesi-Oncology ( Site 1308)
city: Istanbul
country: Turkey
facility: Istanbul University Capa Campus ( Site 1314)
city: Istanbul
country: Turkey
facility: Acibadem Universitesi Atakent Hastanesi ( Site 1319)
city: İstanbul
country: Turkey
facility: Acıbadem Maslak Hastanesi-Medical Oncology ( Site 1321)
city: Istanbul
country: Turkey
facility: Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1302)
city: Istanbul
country: Turkey
facility: TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1316)
city: Istanbul
country: Turkey
facility: Marmara Universitesi Pendik Egitim Arastirma Hastanesi-Medical Oncology ( Site 1305)
city: Izmir
country: Turkey
facility: Ege Universitesi Tip Fakultesi Hastanesi ( Site 1300)
city: İzmir
country: Turkey
facility: Dokuz Eylul Universitesi Hastanesi ( Site 1323)
city: Izmir
country: Turkey
facility: I.E.U. Medical Point Hastanesi-Oncology ( Site 1310)
city: Kocaeli
country: Turkey
facility: Kocaeli Üniversitesi ( Site 1313)
city: Malatya
country: Turkey
facility: Inonu Universitesi ( Site 1309)
city: Dnipro
country: Ukraine
facility: Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council ( Site 3650)
state: Dnipropetrovska Oblast
city: Kryvyi Rih
country: Ukraine
facility: MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional-Chemotherapy department ( Site 3657)
state: Dnipropetrovska Oblast
city: Ivano-Frankivsk
country: Ukraine
facility: Communal Non-Commercial Enterprise "Prykarpatski Clinical Oncological Center" of Ivano-Frankivsk Reg ( Site 3663)
state: Ivano-Frankivska Oblast
city: Kharkiv
country: Ukraine
facility: MNPE Regional Center of Oncology ( Site 3665)
state: Kharkivska Oblast
city: Kharlkiv
country: Ukraine
facility: SO"Grigoriev Inst for Med Radiolgy and Oncology of NAMS of Ukraine" ( Site 3666)
state: Kharkivska Oblast
city: Kropyvnytskyi
country: Ukraine
facility: Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 3656)
state: Kirovohradska Oblast
city: Khodosivka
country: Ukraine
facility: Asklepion Medical Center ( Site 3667)
state: Kyivska Oblast
city: Kyiv
country: Ukraine
facility: National Cancer Institute-Department of Minimally Invasive and Endoscopic Surgery, Interventional R ( Site 3658)
state: Kyivska Oblast
city: Kyiv
country: Ukraine
facility: Municipal non-profit enterprise "Kyiv City Clinical Oncology Center" of executive body of Kyiv City ( Site 3651)
state: Kyivska Oblast
city: Lviv
country: Ukraine
facility: Municipal institution of Lviv regional council Lviv Oncology-Chemotherapy ( Site 3653)
state: Lvivska Oblast
city: Odessa
country: Ukraine
facility: Odessa Regional Oncology Center ( Site 3655)
state: Odeska Oblast
city: Sumy
country: Ukraine
facility: Sumy regional clinical oncological dispensary-Oncothoracic department ( Site 3661)
state: Sumska Oblast
city: Vinnytsia
country: Ukraine
facility: Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" ( Site 3662)
state: Vinnytska Oblast
city: Uzhhorod
country: Ukraine
facility: Transcarpathian Regional Clinical Oncology Center-Chemotherapy dept. ( Site 3652)
state: Zakarpatska Oblast
city: Zaporizhzhia
country: Ukraine
facility: Municipal non-profit enterprise "Zaporizhzhia regional clinical hospital" of Zaporizhzhia regional c ( Site 3664)
state: Zaporizka Oblast
city: Aberdeen
country: United Kingdom
facility: Aberdeen Royal Infirmary-Department of Oncology ( Site 0521)
state: Aberdeen City
city: Edinburgh
country: United Kingdom
facility: Western General Hospital ( Site 0502)
state: Edinburgh, City Of
city: Manchester
country: United Kingdom
facility: The Christie ( Site 0516)
state: England
city: Sheffield
country: United Kingdom
facility: Weston Park Hospital ( Site 0519)
state: England
city: Broomfield
country: United Kingdom
facility: Mid Essex Hospitals Service Trust. Broomfield Hospital ( Site 0503)
state: Essex
city: Glasgow
country: United Kingdom
facility: The Beatson West of Scotland Cancer Centre ( Site 0506)
state: Glasgow City
city: Preston
country: United Kingdom
facility: Royal Preston Hospital ( Site 0518)
state: Lancashire
city: London
country: United Kingdom
facility: Barts Health NHS Trust ( Site 0512)
state: London, City Of
city: London
country: United Kingdom
facility: University College London Hospital-Cancer Clinical Trials Unit ( Site 0520)
state: London, City Of
city: London
country: United Kingdom
facility: Royal Free Hospital ( Site 0507)
state: London, City Of
city: London
country: United Kingdom
facility: Royal Marsden Hospital ( Site 0505)
state: London, City Of
city: London
country: United Kingdom
facility: Sarah Cannon Research UK ( Site 0504)
state: London, City Of
city: Belfast
country: United Kingdom
facility: Belfast City Hospital ( Site 0508)
state: Northern Ireland
city: Nottingham
country: United Kingdom
facility: Nottingham University Hospitals NHS Trust ( Site 0510)
state: Nottinghamshire
city: Leeds
country: United Kingdom
facility: St James University Hospital ( Site 0509)
city: Sutton
country: United Kingdom
facility: The Royal Marsden NHS Foundation Trust. ( Site 0513)
city: Wolverhampton
country: United Kingdom
facility: New Cross Hospital-Department of Oncology ( Site 0517)
Study officials:
affiliation: Merck Sharp & Dohme LLC
name: Medical Director
role: STUDY_DIRECTOR
References:
citation: Robert C, Carlino MS, McNeil C, Ribas A, Grob JJ, Schachter J, Nyakas M, Kee D, Petrella TM, Blaustein A, Lotem M, Arance A, Daud AI, Hamid O, Larkin J, Anderson J, Krepler C, Grebennik D, Long GV. Seven-Year Follow-Up of the Phase III KEYNOTE-006 Study: Pembrolizumab Versus Ipilimumab in Advanced Melanoma. J Clin Oncol. 2023 Aug 20;41(24):3998-4003. doi: 10.1200/JCO.22.01599. Epub 2023 Jun 22.
citation: Long GV, Carlino MS, McNeil C, Ribas A, Gaudy-Marqueste C, Schachter J, Nyakas M, Kee D, Petrella TM, Blaustein A, Lotem M, Arance AM, Daud AI, Hamid O, Larkin J, Yao L, Singh R, Lal R, Robert C. Pembrolizumab versus ipilimumab for advanced melanoma: 10-year follow-up of the phase III KEYNOTE-006 study. Ann Oncol. 2024 Dec;35(12):1191-1199. doi: 10.1016/j.annonc.2024.08.2330. Epub 2024 Sep 15.