Clinical trial NCT06176872: Cardiac CT Angiography in Patients With Acute Ischemic Stroke
Official title: Assessment of Cardiac CT Angiography in Patients Undergoing Thrombectomy for Ischemic Stroke
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke
Coronary Artery Disease
Keywords: Computed Tomography Angiography
Lead sponsor: Universitätsklinikum Hamburg-Eppendorf
Sponsor class: OTHER
Collaborators: name: Siemens Healthcare Diagnostics Inc
First posted: 2023-12-20
Enrollment: 165
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aged 40 years or above, presenting at the Emergency Department of the University Medical Center Hamburg-Eppendorf (primary care clinic) with a suspected AIS.

Brief summary: Mortality rates after acute ischemic stroke remain high despite continuously improving treatment. In this context, it is important to note that a relevant portion of acute ischemic stroke patients die from adverse cardiovascular events, such as myocardial infarction, rather than from complications associated with the stroke itself. A possible reason might be that this patient group often suffers from at least moderate asymptomatic coronary artery disease. This study seeks to integrate cardiac computed tomography angiography into the standard-of-care diagnostic protocol of acute ischemic stroke. The aim of this prospective mono-centric trial is to enable accurate diagnosis of therapy-relevant coronary artery disease, other concomitant cardiac findings and cardiac causes of acute ischemic stroke, without delaying stroke therapy. In the long-run, the goal is to investigate whether cardiac computed tomography angiography and the resulting therapeutic measures (interventions or medications added) can improve functional outcome and rate of adverse cardiac complications in patients with acute ischemic stroke compared to a retrospective matched-cohort of patients without cardiac CT imaging.


Eligibility criteria: Inclusion Criteria:

* Patients aged 40 years or above, presenting at the Emergency Department of the University Medical Center Hamburg-Eppendorf with a suspected acute ischemic stroke and a relevant neurological deficit (NIHSS score \> 4).

Exclusion Criteria:

* A causal differential diagnosis for the acute stroke syndrome with absent intracranial vessel occlusion.
* No correlation for the patients' symptoms in the cranial CTA (no vessel obstruction).

Primary outcomes:
measure: Diagnosis of therapy-relevant CAD and concomitant cardiac findings resulting in new therapeutic measurements.
timeFrame: 1 day at hospital discharge
Secondary outcomes:
measure: The rate of adverse cardiovascular events (MACE).
timeFrame: 90 and 365 days
Other outcomes:
Locations:
Study officials:
affiliation: Universitätsklinikum Hamburg-Eppendorf
name: Gabriel Broocks, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Universitätsklinikum Hamburg-Eppendorf
name: Mathias Meyer, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Universitätsklinikum Hamburg-Eppendorf
name: Jennifer Erley, MD
role: PRINCIPAL_INVESTIGATOR
References: