Clinical trial NCT06976281: Effect of Intradialytic Blood Flow Restriction Training on Functional Capacity, Estimated Glomerular Filtration Rate and Health Related Quality of Life in Patients on Hemodialysis
Official title: Effect of Intradialytic Blood Flow Restriction Training on Functional Capacity, Estimated Glomerular Filtration Rate and Health Related Quality of Life in Patients on Hemodialysis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Blood Flow Restriction Training
Glomerular Filtration Rate
Quality of Life
Hemodialysis
Lead sponsor: Beni-Suef University
Sponsor class: OTHER
First posted: 2025-05-16
Enrollment: 30
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: this study was done to investigate the effect of intradialytic blood flow restriction training on functional capacity, estimated glomerular filtration rate and health related Quality of life in patients on Hemodialysis

Detailed description: Chronic kidney disease affects 10% to 15% of the population and is characterized by a progressive decline in glomerular filtration rate. The disease can lead to frailty, muscle mass wasting, and sarcopenia, affecting functional mobility and quality-of-life measures. The increased protein catabolism in Chronic kidney disease is partly due to inflammatory status, nutrient loss during dialysis, and musculoskeletal system changes. Assessment of muscle functionality can provide additional diagnostic and prognostic information for clinical outcomes, quality of life, and mortality rates. Exercise training with blood flow restriction is a potential method for clinical musculoskeletal rehabilitation, potentially improving strength, physical function, blood pressure control, glucose homeostasis, autonomic function, renal deterioration, dialysis adequacy, and antioxidant defenses.

Eligibility criteria: Inclusion Criteria:

All patients were

1. Both sex aged from forty to sixty years
2. Stable chronic hemodialysis patient (\< 3 months)
3. Participants will be deemed medically eligible by their treating physician before participation in the present study
4. Free from any other disease could interfere with exercise

Exclusion Criteria:

1. Hemodynamic instability during hemodialysis over the last month
2. Neurodegenerative diseases
3. Autoimmune diseases (i.e., lupus erythematosus)
4. Surgery within the past 3 months
5. Severe arrhythmia, angina or cerebrovascular disease
6. Unstable on dialysis
7. Any musculoskeletal problem interfere with exercise

Primary outcomes:
measure: assessment of change of estimated glomerular filtration rate
timeFrame: at baseline and after 8 weeks
Secondary outcomes:
measure: assessment of change of Limb Occlusion Pressure
timeFrame: at baseline and after 8 weeks
measure: assessment of change of Glucose Homeostasis
timeFrame: at baseline and after 8 weeks
measure: assessment of change of upper limb Muscle Strength
timeFrame: at baseline and after 8 weeks
measure: assessment of change of lower limb Muscle Strength
timeFrame: at baseline and after 8 weeks
Other outcomes:
Locations:
city: Banī Suwayf
country: Egypt
facility: out-patient clinic, faculty of physical therapy, beni-suef University
Study officials:
References: