Clinical trial NCT00954031: Impact of Anti-inflammatory and Antibiotic Therapy on the Emergence of Peri-tonsillar Abscess
Official title: Impact of Anti-inflammatory and Antibiotic Therapy on the Emergence of Peri-tonsillar Abscess
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Abscess, Peritonsillar
Lead sponsor: Nantes University Hospital
Sponsor class: OTHER
First posted: 2009-08-06
Enrollment: 711
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients, adult or child, including the diagnosis of APA was made, after consulting their physician

Brief summary: Analyze in children and adults, risk factors in the onset of the APA. The main hypothesis focuses on the use of anti-inflammatory in the context of pharyngitis or sore throat before the symptoms of ABS. Secondary objectives:

1. - Analyze the implementation of a rapid diagnostic test and its result on the occurrence of an ABS
2. - Measure the frequency of prescription and describe the reasons for not prescribing an antibiotic for patients who consulted for a sore throat and having developed a PLA
3. - Describe the microbial flora could puncture of patients hospitalized for APA


Eligibility criteria: Inclusion Criteria:

* clinical existence of a PLA (phlegmon), validated by a senior ENT, usually (but not necessarily) following a request by an emergency. The visible appearance to the merits throat must justify puncture. Cases will be included whether or not they had consulted for a "sore throat" in the 10 days preceding the date of diagnosis

Exclusion Criteria:

* Neoplastic disease of the throat, scalable Hematologic with tonsillar localization History of tonsillectomy

Primary outcomes:
measure: The principal judgement criterion of the study is the positive diagnosis of an APA. The explanatory variables to meet the main objective is the drug exposure (anti-inflammatory)
timeFrame: 2,5 years
Secondary outcomes:
measure: The explanatory variables to meet the secondary objectives are: - The creation of a TDR - The prescription of antibiotics - The diagnosis of angina Strep Group A - The identification of a group A streptococcus in t
timeFrame: 2,5 years
Other outcomes:
Locations:
city: Nantes
country: France
facility: Nantes University Hospital
state: Pays de Loire
city: Angers
country: France
facility: Angers university Hospital
city: Caen
country: France
facility: Caen universty Hospital
city: Clermont Ferrand
country: France
facility: Clermont Ferrand University Hospital
city: Grenoble
country: France
facility: Grenoble University Hospital
city: Lille
country: France
facility: Lille University Hospital
city: Paris
country: France
facility: Ambroise Paré Hospital
city: Paris
country: France
facility: Paris-Bichat-Hospital
city: Paris
country: France
facility: Paris-Cochin Hospital
city: Paris
country: France
facility: Paris-Lariboisière Hospital
city: Paris
country: France
facility: Paris-Tenon-Hospital
city: Poitiers
country: France
facility: Poitiers University Hospital
city: Rennes
country: France
facility: Rennes University hospital
city: Toulouse
country: France
facility: Toulouse University Hospital
city: Tours
country: France
facility: Tours University Hosipital
Study officials:
affiliation: Nantes University Hospital
name: Gilles Potel, PhD
role: PRINCIPAL_INVESTIGATOR
References: