louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05502120: A Comparison of Vie-Scope and Macintosh Blade Laryngoscopes in Morbidly Obese.
Official title: A Comparison of Visualization of the Larynx With the Vie Scope Versus Standard Macintosh Laryngoscope in Morbidly Obese Patients.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity, Morbid
Intubation Complication
Keywords: morbid obesity
endotracheal intubation
Lead sponsor: Medical University of Lodz
Sponsor class: OTHER
First posted: 2022-08-16
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: Macintosh laryngoscope is still considered a standard for tracheal intubation, however, visualization of the glottis may be inadequate mainly in morbidly obese patients. The Vie Scope is a novel type of laryngoscope consisting of a straight, shielded, illuminated tube that offers intubation via a bougie using the paraglossal technique. In this prospective, non-randomized study, we tested the research hypothesis that the use of Vie Scope may improve visualization of the larynx in comparison with the Macintosh blade.

Detailed description: Prior to tracheal intubation, all patients were placed in the head-elevated laryngoscopy position (HELP). All study subjects were anesthetized with the concordance to European Society for Peri-Operative Care of Obese Patient (www.espcop.eu) protocols: proper positioning, pre-oxygenation with CPAP, induction of anesthesia with propofol 2.0 mg kg-1 of corrected body weight; for muscle relaxation rocuronium 0.6 mg kg-1 of ideal body weight (IBW); ketamine 50 mg ; lidocaine 100 mg, and fentanyl 0.1 mg. After achieving 100% neuromuscular block confirmed by TOF-Watch monitoring, laryngoscopy was performed by the anesthesiologist familiar with the use of both Vie Scope and Macintosh blade laryngoscope, and also experienced in bariatric anesthesia. All anesthesiologists participating in the study underwent training with Vie Scope on the manikin model.

The evaluation of glottis visualization in direct laryngoscopy using Cormack-Lehane scale (CL) in all patients was performed in sequence using two laryngoscopes: first Macintosh blade laryngoscope (MCL) and then Vie Scope laryngoscope (VS). Tracheal intubation was performed with the VS. The study subjects all received oxygen using nasal CPAP in order to maintain sufficient oxygenation

Eligibility criteria: Inclusion Criteria:

* morbid obesity BMI\>40 kg/m2
* scheduled for elective bariatric procedure
* no anatomy abnormalities of upper airway

Exclusion Criteria:

* lack of conscent
* predicted difficult intubation

Primary outcomes:
measure: Improvement in laryngeal view
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: intubation efficiency
timeFrame: through study completion, an average of 1 year
Other outcomes:
Locations:
city: Łódź
country: Poland
facility: Medical University of Lodz, Poland
Study officials:
References:
Clinical trial NCT03094520: Cognitive Embodiment Activation by tDCS
Official title: Effects of Transcranial Direct Current Stimulation (tDCS) on Gestural-verbal Brain Associations: the Role of Cognitive Embodiment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Young Adults
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2017-03-29
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The main objective of the proposed research is to extend our understanding of how gesture and language interact, focusing on the role of cognitive embodiment in this interaction, and to explore the neural systems that support links between language and actions systems.


Eligibility criteria: Inclusion Criteria:

* Right handedness
* unobtrusive neuropsychological screening

Exclusion Criteria:

* History of severe alcoholism or use of drugs.
* Severe psychiatric disorders such as depression, psychosis (if not in remission) and severe untreated medical problems.
* Contraindication for MRT (claustrophobia, metallic implants, ferromagnetic metals in the body, disorders of thermoregulation, pregnant women).

Primary outcomes:
measure: response time in semantic decision task
timeFrame: assessed during stimulation or sham stimulation of semantic decision task (last approximately 10 min) at specific timepoint within 2 weeks
measure: performance in attentional load task
timeFrame: assessed during stimulation or sham stimulation of attentional load task (last approximately 6 min) at specific timepoint within 2 weeks
measure: performance in motor task
timeFrame: assessed during stimulation or sham stimulation of motor task (last approximately 4 min) at specific timepoint within 2 weeks
Secondary outcomes:
measure: Functional connectivity predictors
timeFrame: assessed during baseline testing
measure: Other cognitive outcomes: change in working memory performance
timeFrame: change in working memory performance from baseline after 30 min (approximately)
measure: Other cognitive outcomes: change in Attention performance
timeFrame: change in attention performance from baseline after 30 min (approximately)
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Charité
Study officials:
affiliation: Charite Universitätsmedizin
name: Agnes Floeel, Prof
role: PRINCIPAL_INVESTIGATOR
References:
citation: Cohen-Maximov T, Avirame K, Floel A, Lavidor M. Modulation of Gestural-verbal Semantic Integration by tDCS. Brain Stimul. 2015 May-Jun;8(3):493-8. doi: 10.1016/j.brs.2014.12.001. Epub 2014 Dec 11.
citation: Floel A, Ellger T, Breitenstein C, Knecht S. Language perception activates the hand motor cortex: implications for motor theories of speech perception. Eur J Neurosci. 2003 Aug;18(3):704-8. doi: 10.1046/j.1460-9568.2003.02774.x.
citation: Floel A, Rosser N, Michka O, Knecht S, Breitenstein C. Noninvasive brain stimulation improves language learning. J Cogn Neurosci. 2008 Aug;20(8):1415-22. doi: 10.1162/jocn.2008.20098.
Clinical trial NCT04141020: Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms
Official title: Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Cerebral Aneurysm
Lead sponsor: University of Miami
Sponsor class: OTHER
Collaborators: name: National Institute of Neurological Disorders and Stroke (NINDS)
First posted: 2019-10-28
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The objective of this study is to explore the effects of Sirolimus on the underlying molecular alterations of cerebral aneurysms.


Eligibility criteria: Inclusion Criteria:

1. Undergoing one of the following procedures at Jackson Memorial Hospital:

   * Clipping of an unruptured cerebral artery aneurysm
   * Endovascular treatment of unruptured cerebral aneurysms (including those receiving coiling)
2. ≥ 18 years of age
3. Willing and able to give informed consent

Exclusion Criteria:

1) Subjects meeting any of the following criteria will be excluded:

* Dissecting, traumatic, or mycotic brain aneurysm.
* Women who are pregnant, or have a positive urine or blood (β-hCG) pregnancy test.
* Women who are breastfeeding.
* Any clinically significant psychiatric or psychological disease, which would preclude the patient from completing the protocol.
* Patients with known Human Immunodeficiency Virus (HIV) infection or other known immunodeficiency.
* Patient with renal or liver failure
* Interstitial pneumonitis
* History of lymphoma
* History of skin cancer
* Hypersensitivity to sirolimus
* Severe or unstable concomitant condition disease or chronic condition, which in the opinion of the investigator could affect assessment of the safety or efficacy of study intervention.

Primary outcomes:
measure: Change in gene expression from control arteries.
timeFrame: Day 18
measure: Change in gene expression between blood samples.
timeFrame: Day 18
measure: Change in gene expression.
timeFrame: Day 18
Secondary outcomes:
Other outcomes:
Locations:
city: Miami
country: United States
facility: University of Miami
state: Florida
Study officials:
affiliation: University of Miami
name: Robert M Starke, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04697420: Transversus Abdominis Plane Block Versus Paravertebral Block for Post Operative Pain Relief in Open Renal Surgeries
Official title: Transversus Abdominis Plane Block Versus Paravertebral Block for Post-operative Pain Relief Following Open Renal Surgeries: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2021-01-06
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Pain relief after renal surgeries is essential as it may lead to reduction in the incidence of many post operative complications .

There are a lot of regional anesthetic techniques to provide analgesia postoperatively as paravertebral block (PVB) and transversus abdominis plane (TAP) block.

TAP block has been used to provide postoperative analgesia in a lot of abdominal surgeries including upper abdominal surgeries.It is safer technique than PVB, but the effectiveness of TAP block is unknown in comparison with PVB in post operative analgesia after renal surgeries .

Detailed description: Pain relief after renal surgeries is essential as it may lead to reduction in the incidence of post operative respiratory complications . A lot of patients presented to these operations may have comorbidities as impaired renal function and respiratory problems , conditions like these may contraindicate aministration of systemic analgesia as opioids .

There are a lot of techniques to provide analgesia postoperatively as paravertebral block (PVB) and transversus abdominis plane (TAP) block .

Paravertebral block is effective technique for post operative analgesia for upper abdominal surgeries , but it may be associated with some complications as : pneumothorax , spread of local anesthetic to the epidural space and paravertebral blood vessels , and this may lead to systemic toxicity of local anesthetic .

TAP block has been used to provide postoperative analgesia in a lot of abdominal surgeries including upper abdominal surgeries , but it is safer technique than PVB , but the effectiveness of TAP block is unknown in comparison with PVB in post operative analgesia after renal surgeries .

Eligibility criteria: Inclusion Criteria:

* Aged 18 - 60 years
* ASA I-II class

Exclusion Criteria:

* Patient refusal
* Any contraindication of regional anesthesia block (Coagulopathy,infection at the needle insertion site)
* Patients with allergy to amide local anesthetics or medication included in the study.

Primary outcomes:
measure: comparison between the post operative analgesic effect of transversus abdominis plane block and paravertebral block
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University
Study officials:
affiliation: Professor of anesthesia, intensive care and pain management , formerly head of the department
name: Essam Ezzat, Professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT05998720: Application of New Magnetic Resonance UTE Technique in Hip Joint Lesions
Official title: Application of New Magnetic Resonance Technique-UTE in Hip Joint Lesions
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Hip Disease
Lead sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2023-08-21
Enrollment: 150
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who meet the inclusion criteria

Brief summary: Explore the imaging and quantitative monitoring of hip bone, cartilage and ligament by magnetic resonance UTE technology, combined with QCT and DXA technology, to provide a more accurate basis for clinical evaluation and treatment.

Detailed description: Osteoporosis is a systemic bone metabolism-related disease characterized by decreased bone mass per unit volume, increased bone fragility, decreased bone density, thinning of the bone cortex and changes in bone microstructure. It often occurs in the lumbar spine and hip joint. Femoral neck fracture is a common complication of hip osteoporosis, which seriously affects people's quality of life. UTE technology can clearly image and quantify human cortical bone and cancellous bone, and advanced UTE technology such as STAIR-UTE and UTE-MT have made some progress in the field of osteoporosis. The purpose of this study was to explore UTE technology for imaging and quantitative study of cortical bone, cancellous bone and cartilage of hip joint, and to find more accurate imaging methods for clinical evaluation of hip osteoporosis and other diseases.

Eligibility criteria: Inclusion Criteria:

1. Patients with past or suspected osteoporosis and bone loss;
2. Patients with previous femoral neck fracture;
3. Patients with avascular necrosis of femoral head;
4. Hip osteoarthritis patients.

Exclusion Criteria:

1. Patients with metal implants in corresponding parts;
2. Claustrophobic.

Primary outcomes:
measure: proton density fat fraction (PDFF)
timeFrame: Baseline (before surgery)
measure: T2 relaxation rate
timeFrame: Baseline (before surgery)
measure: Magnetization Transfer Ratio (MTR)
timeFrame: Baseline (before surgery)
measure: T1rho
timeFrame: Baseline (before surgery)
Secondary outcomes:
measure: Subjective rating values
timeFrame: Baseline (before surgery)
Other outcomes:
Locations:
city: Zhuhai
country: China
facility: Radiography department
state: Guangdong
Study officials:
affiliation: Fifth Affiliated Hospital, Sun Yat-Sen University
name: Shaolin Li
role: STUDY_DIRECTOR
References:
Clinical trial NCT04000620: Imaging-based Deep Learning for Lung Cancer Diagnosis and Staging
Official title: The Role of CNN Architecture-based Transfer Learning of Medical Imaging in Lung Cancer Diagnosis and Staging
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Lung Cancer
Lead sponsor: Wuhan Union Hospital, China
Sponsor class: OTHER
First posted: 2019-06-27
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Lung cancer patients with PET/CT or CT examination before any cancer-specific treatment

Brief summary: Lung cancer diagnosis and staging are two fundamental and critical issue in clinical lung cancer management and therapeutic decision-making. Invasive procedures for pathologic analysis are gold standard for diagnosis and staging, however, invasive procedures related-complications are inevitable. Noninvasive medical imaging is a powerful tool, however there is almost no room for improvement just according to the experience of radiologist and clinician. The researchers will investigate the role of computer based deep learning of medical imaging in the diagnosis of lesion of lung, lymph node and other sites suspected with metastasis.

Detailed description: Radiologist

Eligibility criteria: Inclusion Criteria:

* Pathological diagnosis of lung cancer
* PET/CT or CT examination before any cancer-specific treatment

Exclusion Criteria:

* A history of other malignancies

Primary outcomes:
measure: pathologic result revealed cancer cell involvement in lesion
timeFrame: 1 month after the pathologic test
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Wuhan Union Hospital
state: Hubei
Study officials:
References:
Clinical trial NCT05834920: Effects of Neurofeedback and Transcranial Pulse Stimulation on Attention
Official title: Effects of Neurofeedback and Transcranial Pulse Stimulation on Attention
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Attention Difficulties
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2023-04-28
Enrollment: 180
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The present study aims to examine and compare the effectiveness of transcranial pulse stimulation and neurofeedback among adults who are weak in attention.


Eligibility criteria: Inclusion Criteria:

* Aged 20 years and above
* Right-handed
* Normal/corrected hearing and vision
* Having basic literacy skills
* Having sustained attention scores below the threshold

Exclusion Criteria:

* Having medical history related to brain
* Having mild cognitive impairment
* Showing symptoms of depression and anxiety
* Having intellectual disability based on IQ scores
* Having diagnoses of any psychiatric or cognitive disorders besides attention deficit hyperactivity disorder (ADHD) inattentive and combined types
* Having long-term history of smoking cigarettes
* Engaged in alcohol and/or substance abuse
* Having history of hemophilia or other blood clotting disorders or thrombosis
* Having corticosteroid treatment within the last six weeks before first intervention
* Having contraindications for MRI scanning

Primary outcomes:
measure: Change from baseline in Conners' Continuous Performance Test 3rd Edition
timeFrame: Baseline, week 4, week 8, week 12, week 16
measure: Change from baseline in gradCPT continuous performance test
timeFrame: Baseline, week 4, week 8, week 12, week 16
Secondary outcomes:
measure: Change from baseline in Stroop task
timeFrame: Baseline, week 4, week 8, week 12, week 16
measure: Change from baseline in General Health Questionnaire
timeFrame: Baseline, week 4, week 8, week 12, week 16
measure: Change from baseline in Goal Orientation Scale
timeFrame: Baseline, week 4, week 8, week 12, week 16
measure: Change from baseline in N-back task
timeFrame: Baseline, week 4, week 8, week 12, week 16
measure: Change from baseline in Color Trails Test
timeFrame: Baseline, week 4, week 8, week 12, week 16
measure: Change from baseline in Attentional Control Scale
timeFrame: Baseline, week 4, week 8, week 12, week 16
measure: Change from baseline in Rosenberg Self-esteem Scale
timeFrame: Baseline, week 4, week 8, week 12, week 16
measure: Change from baseline in Social Connectedness Scale
timeFrame: Baseline, week 4, week 8, week 12, week 16
measure: Change from baseline in Hospital Anxiety and Depression Scale (HADS)
timeFrame: Baseline, week 4, week 8, week 12, week 16
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: HKU InnoCentre of Clinical Neuropsychology
Study officials:
References:
Clinical trial NCT04375020: GABA and Beta-cell Regeneration
Official title: GABA From Medical Nutrition to Pancreatic Beta-cell Regeneration
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Keywords: type 1diabetes, gaba
Lead sponsor: Ministry of Health and Population, Egypt
Sponsor class: OTHER_GOV
First posted: 2020-05-05
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: observation prospective study 100 patients with type I diabetes were int 2 groups, had been monitored in a private clinic, number 50 each group, with 30 females and 20 males after the written consent of all patients.

All the patients Lied between 18-25 years old with 5-10 years of diabetes onset.

Brief summary: GABA(gamma-Aminobutyric acid) may be used for decreasing anti-gad antibodies and leads beta-cell regeneration.

Detailed description: 100 patients with type I diabetes were in 2 groups, had been monitored in a private clinic, number 50 each group, with 30 females and 20 males after the written consent of all patients.

All the patients Lied between 18-25 years old with 5-10 years of diabetes onset.

The first group was on insulin therapy in the form of toujeo once daily and Novorapid 3 times daily and they received GABA nutritional supplement 750mg per day.

The second group was only on insulin injection in the form of toujeo once daily and Novorapid 3 times daily.

In the first group;the investigator measured fasting c peptide levels before and after 6 months of GABA 750mg daily.Also,the investigator measured anti gad antibodies before and after 6 months of treatment.

In the second group,the investigator measured c peptide levels and anti-gad antibodies at the beginning of the trial and after 6 months.

Eligibility criteria: Inclusion Criteria:

- type 1 diabetes patients age from 18 to 25 years on basal bolus insulin

Exclusion Criteria:

thyroid problems liver disease kidney disease

Primary outcomes:
measure: gaba decrease anti gad antibodies
timeFrame: 6 months
measure: gaba improve c peptide levels
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Mahmoud Younis
Study officials:
References: