Clinical trial NCT04155281: New Psychoactive Substances in Intoxicated Patients During the Winter Activities
Official title: Consumption of New Psychoactive Substances in Intoxicated Patients During the Winter Activities
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Intoxication
Psychoactive Substance Use
Keywords: Intoxication; Psychoactive Substance ; Ski
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2019-11-07
Enrollment: 87
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patient will be included at admission to hospital (Grenoble alpes university hospital, CH Albertville-Moûtiers and Centre Hospitalier Métropole Savoie/Chambéry). After collecting his/her non-opposition to the study, the urine sample of the medical care will be kept and send to the central lab for analysis and dentifation of new psychoactive substances.

Brief summary: The purpose of this research is to identify the New Psychoactive Substances (NPS) that are responsible for intoxicating patients in ski resort during winter activities.

Detailed description: The New Psychoactive Substances expose to an additional risk of overdose or death due to their potency. These New Psychoactive Substances are used voluntarily by users wishing to test new substances, but also involuntarily because of association (unknowingly users) with more "conventional" drugs such as cocaine or heroin in the self-administered powder. These intoxications are still poorly known and the investigators believe that the identification of New Psychoactive Substances among the drugs consumed, and the association of their consumption with the appearance of a particular symptomatology allow the physician to guide the diagnosis and facilitate the care of future patients.

Eligibility criteria: Inclusion Criteria:

* Admission to emergency, resuscitation or intensive care departments involved in the study
* Anamnestic and / or clinical suspicion of acute drug poisoning according to International Classification of Diseases-10 criteria
* Patient coming from a ski resort from the pre-established list
* urine sample available as part of the treatment
* person understanding French or English
* Non-opposition to the study

Exclusion Criteria:

* Suspicion of alcohol intoxication alone
* Suspicion of voluntary drug poisoning
* Suspicion of intentional intoxication by others
* Pregnant or breastfeeding women
* Major mentioned in Articles L1121-6 and 1121-8 of french public health code
* Patients in the exclusion period of another research involving the human person type 1 or 2

Primary outcomes:
measure: positive urinary sample
timeFrame: Day 0
Secondary outcomes:
measure: incidence of toxidromes
timeFrame: baseline
measure: polyintoxication frequency
timeFrame: baseline
measure: morbidity of intoxication
timeFrame: baseline and month 1
measure: morbidity of intoxication
timeFrame: baseline and month 1
measure: incidence of intoxication medical care
timeFrame: day 1
Other outcomes:
Locations:
city: Chambéry
country: France
facility: Centre Hospitalier Métropole Savoie (Chaméry)
state: Savoie
city: Albertville
country: France
facility: CH Albertville Moutiers
city: Grenoble
country: France
facility: University Hospital Grenoble
Study officials:
affiliation: University Hospital, Grenoble
name: Damien VIGLINO, MD, PhD
role: PRINCIPAL_INVESTIGATOR
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