louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03031860: Semi-quantitative Cough Strength Score (SCSS)
Official title: Impact of Semi-quantitative Cough Strength Score as a Strong Predictor for Extubation Outcome in Head Trauma Patients: a Prospective Descriptive Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mechanical Ventilation
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-01-26
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The sample of this study include 80 head trauma patients from both sex of critically ill mechanically ventilated patient admitted to trauma Intensive Care Unit (ICU).

Brief summary: Cough strength score will give true prediction of Extubation outcome

Detailed description: Head trauma patients were evaluated for readiness to be weaned off mechanical ventilation. If they had completed an Spontaneous Breathing Trial (SBT) before extubation. To measure Semiquantitative Cough Strength Score (SCSS), the investigator will put the patients at 30° to 45°, measure SCSS, first. The investigator enhance the patient to cough with as much effort as, when the investigator disconnect the ventilator. The cough strength was scored from 0 to 5 as follows: 0 = no cough on command, 1 = audible movement of air through the endotracheal tube but no audible cough, 2 = weakly (barely) audible cough, 3 = clearly audible cough, 4 = stronger cough and 5 = multiple sequential strong coughs.

Eligibility criteria: Inclusion Criteria:

* The study included 80 adult male and female patients' their ages between 18-65 years admitted to trauma ICU with head trauma, on mechanical ventilation more than 24 hours and was ready to be weaned off from mechanical ventilation after successful spontaneous breathing trial and Glasgow Coma Scale (GCS) score \> 8 before extubation

Exclusion Criteria:

• Patients who had undergone tracheostomy before extubation, GCS ≤ 8, chest trauma (ribs fracture and lung contusion) and patients with chronic chest disease (Chronic obstructive pulmonary disease, tuberculosis and cancer lung) were excluded from the study.

Primary outcomes:
measure: Extubation outcome (success or failure), is the patient reintubate again or not and it's correlation with the level of Cough Strength Score
timeFrame: within 6 hours postextubation
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut university faculty of medicine
Study officials:
affiliation: assiut university faculty of nursing
name: Eman M Aziz
role: PRINCIPAL_INVESTIGATOR
References:
citation: White AC. Long-term mechanical ventilation: management strategies. Respir Care. 2012 Jun;57(6):889-97; discussion 898-9. doi: 10.4187/respcare.01850.
Clinical trial NCT05929560: Digital Impression in Neonates
Official title: Diagnostic Evaluation and Guardian Assessment of Using Digital Impression in Neonates Versus the Conventional Techniques.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Unilateral Complete Cleft Lip and Palate
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2023-07-03
Enrollment: 7
Sex: ALL
Minimum age (years): 1
Maximum age (years): 28
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Intervention model description: Paired design "Same patients receive conventional impression and digital"
Primary purpose: TREATMENT

Brief summary: The goal of this \[clinical trial\] is to \[explore the attitudes of guardians with different educational background regarding the technique of impression registration as well as the compliance to using feeding appliances \] in \[neonates\].

Researchers will compare \[conventional impression technique to digital impression\]


Eligibility criteria: Inclusion Criteria:

* patients with unilateral complete cleft lip and palate
* neonates

Exclusion Criteria:

* infants and children
* bilateral cleft lip and palatal
* incomplete cleft lip

Primary outcomes:
measure: Deviation of linear measurments
timeFrame: up to 1 month
Secondary outcomes:
measure: Assessment of gaurdian' perception and experience
timeFrame: up to 1 month
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Alexandria Faculty of Dentistry
Study officials:
References:
Clinical trial NCT06310460: Evaluation of "PreCut-Papillectomy" in Difficult Biliary Cannulation
Official title: Prospective Monocentric Cohort Study to Evluate Pre-cut Papillectomy in Patients With Difficult Biliary Cannulation During Endoscopic Retrograde Cholangiopancreaticography
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Cholangiopancreatography, Endoscopic Retrograde
Lead sponsor: Kliniken Ludwigsburg-Bietigheim gGmbH
Sponsor class: OTHER
First posted: 2024-03-15
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing ERCP with intented bile duct cannulation

Brief summary: To evaluate the effectiveness and sefety of papillectomy to enable bile duct access during endoscopic retrograde cholangiography in patients with difficult biliary cannulation.


Eligibility criteria: Inclusion Criteria:

* Difficult cannulation of bile duct

Exclusion Criteria:

* post-surgical upper GI anatomy
* previous endoscopic retrograde cholangiopancreaticography or percutaneous transhepatic cholangiography
* papilla within a diverticulum
* coagulation disorder

Primary outcomes:
measure: Rate of treatment success
timeFrame: During endoscopy
measure: Adverse event rate
timeFrame: Up to 30 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05374460: Factors Affecting Sensory and Motor Learning
Official title: Factors Affecting Sensory and Motor Learning
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Basic Science
Lead sponsor: Indiana University
Sponsor class: OTHER
Collaborators: name: National Institute of Neurological Disorders and Stroke (NINDS)
First posted: 2022-05-16
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: How participants perceive the position of their own hand in various contexts will be examined. This will include changing the visual display to suggest the hand is in a slightly different position, and asking participants to indicate where they think it is by pointing with their other hand.

Detailed description: Hand position can be estimated visually, from an image on the retina, and proprioceptively, from sensors in the joints, muscles, and skin. The brain is thought to weight and combine available sensory estimates to form an integrated multisensory estimate. Inherent in this process is the capacity to realign one or both sensory estimates when they become spatially mismatched, as when washing dishes with the hands immersed in water, which refracts light. It is generally assumed that if a person knows about the sensory mismatch somehow, the realignment will not occur. This assumption will be tested in two experiments by giving people this information in different ways. Expt. A: Conscious awareness of the mismatch will be presented in different ways, or absent. Expt. B: Movement error feedback will be presented in different ways, or absent.

Eligibility criteria: Inclusion Criteria:

* Between the ages of 18-45 years old
* Right-handed.
* Covid has been found to have neurological effects in some people, but mostly the effects on sensorimotor control and neurophysiology are unknown. So we will only include individuals who report being free of Covid symptoms in week preceding testing.

Exclusion Criteria:

* Past or present history of seizure, stroke, any brain or peripheral nerve disease, severe head trauma, or spinal cord surgery.
* Learning or attention conditions such as ADHD.
* Orthopedic or pain conditions, or a history of seriously injured bones, joints or muscles in either arm.
* Lack of normal or corrected-to-normal vision.

Primary outcomes:
measure: Realignment
timeFrame: 1 day
Secondary outcomes:
measure: Visuo-proprioceptive weighting
timeFrame: 1 day
measure: Target estimation variance
timeFrame: 1 day.
Other outcomes:
Locations:
city: Bloomington
country: United States
facility: Hannah Block
state: Indiana
Study officials:
affiliation: Indiana University, Bloomington
name: Hannah J Block
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02987660: Comparison of Topography Guided LASIK With WaveLight® EX500 to SMILE With Zeiss VisuMax
Official title: Comparison of Topography Guided LASIK With WaveLight® EX500 to SMILE With Zeiss VisuMax
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Myopia
Astigmatism
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
First posted: 2016-12-09
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare Topography Guided Laser In Situ Keratomileusis (LASIK) corneal surgery to Small Incision Lenticule Extraction (SMILE) corneal surgery for the treatment of myopia with astigmatism.


Eligibility criteria: Inclusion Criteria:

* Subjects in Singapore must be 21 years of age or older and subjects in Korea must be upon completion of 19 years of age or older due to local regulations;
* Able to comprehend and sign an informed consent form;
* Willing and able to complete all postoperative visits;
* Myopia requiring (a) refractive error correction of -0.5 to -8.0 D optical infinity adjusted manifest refraction sphere with (b) astigmatism correction of -0.75 to -5.0 D manifest refraction cylinder and (c) at least 0.75 D of corneal astigmatism.
* Intended treatment targeted for emmetropia;
* Preoperative best-corrected visual acuity (BCVA) of 0 logMAR or better;
* Other protocol-defined inclusion criteria may apply.

Exclusion Criteria:

* Pregnant or lactating, current or planned, during the course of the study;
* Dry eye;
* Corneal disease;
* Diagnosis of advanced glaucoma;
* Uncontrolled diabetes;
* Other protocol-defined exclusion criteria may apply.

Primary outcomes:
measure: Percentage of Eyes With Manifest Refraction Cylinder Less Than or Equal to 0.5 Diopter (D) at 3 Months
timeFrame: Month 3
Secondary outcomes:
measure: Mean Manifest Refraction Cylinder at 3 Months
timeFrame: Month 3
measure: Mean Uncorrected Visual Acuity (UCVA) at 3 Months
timeFrame: Month 3
Other outcomes:
Locations:
city: Paris
country: France
facility: Alcon Investigative Site
Study officials:
affiliation: Alcon, A Novartis Division
name: Alcon, A Novartis Division
role: STUDY_DIRECTOR
References:
Clinical trial NCT01890460: Evaluation of Liver Disease With Elastography Measurements in Patients Undergoing Liver Transplant Surgery
Official title: Quantitative Evaluation of Liver Disease With Liver Elastography Measurements Using the Supersonic Imagine Aixplorer ShearWaveTM Elastography Ultrasound Machine in Patients Undergoing Liver Transplant Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Liver Transplantation
Lead sponsor: Baylor Research Institute
Sponsor class: OTHER
First posted: 2013-07-01
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing a liver transplant surgery

Brief summary: The purpose of the study is to compare ultrasound measurements of the liver obtained prior to surgery on the skin to measurements obtained during surgery directly on the diseased liver. The objective is to determine if ultrasounds of the liver on the skin can provide accurate measurements of disease of the liver to provide an alternative option to liver biopsies.

Detailed description: A non-invasive, ultrasound platform based, ShearWaveTM Elastography measurement will be obtained at two time points on each qualified patient. The first time point will be in the operating room before the initial incision is made. The second time point involves placement of a small, hand-held modified ultrasound probe directly on the patient's diseased liver during the liver transplant surgery. The probe used in this study is the SuperCurved™SC6-1, capable of a band width of 1-6MHz with 192 elements.

Eligibility criteria: Inclusion Criteria:

* Males and Females over the age of 18
* Patients undergoing a liver transplant surgery

Exclusion Criteria:

* Any person unable to provide informed consent

Primary outcomes:
measure: To obtain quantitative evaluation of the progression of liver disease, using ShearWaveTM Elastography measurements obtained with the Supersonic Imagine Aixplorer ultrasound machine in patients undergoing a liver transplant surgery.
timeFrame: on day of surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Dallas
country: United States
facility: Baylor University Medical Center
state: Texas
Study officials:
affiliation: Baylor Health Care System
name: James Trotter, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02995460: Interval Training Study in Psoriatic Arthritis
Official title: Interval Training Study in Psoriatic Arthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Psoriatic Arthritis
Keywords: Exercise Therapy
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
Collaborators: name: Helse Midt-Norge
First posted: 2016-12-16
Enrollment: 67
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Psoriatic arthritis is a chronical inflammatory disease characterized by pain and reduced physical function. Patients have a higher risk of cardiovascular disease and a higher body mass index.

A pilot study in patients with rheumatoid arthritis has shown positive effect on inflammation after 12 weeks of high-intensity interval training.

The primary aim of this study is to determine whether high-intensity interval training affects the disease activity in psoriatic arthritis. This intervention is believed to result in benefits in terms of inflammation, body composition and risk factors for cardiovascular disease.


Eligibility criteria: Inclusion Criteria:

* fulfilling the CASPAR criteria of psoriatic arthritis
* ability to exercise.

Exclusion Criteria:

* Inability to exercise
* very high disease Activity
* unstable ischemic cardiovascular disease
* severe pulmonary disease
* pregnancy
* breastfeeding
* drug- and alcohol addictions

Primary outcomes:
measure: Patient global assesment (PGA)
timeFrame: Baseline, 3 months (right after intervention), 9 months
measure: Maximal oxygen uptake (VO2 max)
timeFrame: Baseline, 3 months (right after intervention), 9 months
Secondary outcomes:
measure: Total lean mass
timeFrame: Baseline, 3 months (right after intervention), 9 months
measure: Total body fat
timeFrame: Baseline, 3 months (right after intervention), 9 months
Other outcomes:
Locations:
Study officials:
affiliation: Norwegian University of Science and Technology
name: Siri Forsmo, md prof
role: STUDY_DIRECTOR
References:
citation: Thomsen RS, Nilsen TIL, Haugeberg G, Bye A, Kavanaugh A, Hoff M. Impact of High-Intensity Interval Training on Disease Activity and Disease in Patients With Psoriatic Arthritis: A Randomized Controlled Trial. Arthritis Care Res (Hoboken). 2019 Apr;71(4):530-537. doi: 10.1002/acr.23614.
citation: Thomsen RS, Nilsen TIL, Haugeberg G, Bye A, Kavanaugh A, Hoff M. Effect of high-intensity interval training on cardiovascular disease risk factors and body composition in psoriatic arthritis: a randomised controlled trial. RMD Open. 2018 Oct 11;4(2):e000729. doi: 10.1136/rmdopen-2018-000729. eCollection 2018.
citation: Chronaiou I, Thomsen RS, Huuse EM, Euceda LR, Pedersen SJ, Hoff M, Sitter B. Quantifying bone marrow inflammatory edema in the spine and sacroiliac joints with thresholding. BMC Musculoskelet Disord. 2017 Nov 28;18(1):497. doi: 10.1186/s12891-017-1861-1.
Clinical trial NCT02075060: Evaluation of Immediate Preoperative Instillation (IPOI) of Mitomycin C Compared to Early Postoperative Instillation (IPOP) in Non-muscle Invasive Bladder Cancer
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Non Muscle-invasive Bladder Cancer
Keywords: low-grade
NMIBC
Lead sponsor: Poitiers University Hospital
Sponsor class: OTHER
First posted: 2014-03-03
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this pilot study is to assess the efficacy and toxicity of immediate pre-operative instillation of mitomycin C compared to the standard early post-operative .


Eligibility criteria: Inclusion Criteria:

* Age \> 18 years,
* Primary or recurrent bladder tumor with endoscopic papillary aspect,
* One or two bladder tumors,
* Cytology before TURB showing no high-grade cells,
* Patients without tutorship or subordination (ou curatorship),
* Patients under the general social security system or qualifying through a third party,
* Informed consent signed by the patient after clear and fair information.

Exclusion Criteria:

* Age \< 18 years,
* Allergy to mitomycin C,
* Traumatic stenting,
* Upper tract urothelial cancer,
* Urethral invasion,
* History of muscle invasive bladder cancer,
* Extensive tumor (3 cm or more),
* Any contraindication to TURB,
* Simultaneous participation in another clinical research study,
* Patients not insured by the social security or not qualifying through a third party,
* Patients with enhanced protection, namely pregnant or lactating women, persons deprived of their liberty by a judicial or administrative decision, people staying in a health or social institution, adults under legal protection, and finally patients in emergency situations,
* Pregnant or lactating females or women of childbearing potential not willing to use an adequate method of birth control for the duration of the study (i.e. hormonal / mechanical contraceptive : oral, injectable, transdermal, implantable, intrauterine or surgical device: tubal ligation, hysterectomy, total oophorectomy).

Primary outcomes:
measure: PFS
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Kremlin Bicêtre
country: France
facility: Bicêtre Hospital
city: Poitiers
country: France
facility: Poitiers University Hospital
city: Rouen
country: France
facility: Rouen University Hospital
Study officials:
affiliation: Poitiers University Hospital
name: Jacques IRANI, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06930560: HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
Official title: HEARS Neuropsychiatric Symptoms & Hearing Loss: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Alzheimer Disease
Dementia
Hearing Loss
Cognitive Impairment
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2025-04-16
Enrollment: 300
Sex: ALL
Minimum age (years): 60
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: This randomized controlled trial study aims to evaluate a revised hearing care intervention for older adults with Alzheimer's Disease and Related Dementias (ADRD). The community-delivered hearing care intervention utilizes tailored strategies to assess impact on communication, neuropsychiatric symptoms (NPS), and care partner distress.


Eligibility criteria: Inclusion Criteria:

* Age 60 - 100 years old
* English-speaking
* Diagnosis of probable Alzheimer's Disease or other related dementia according to the core clinical criteria outlined in the National Institute on Aging (NIA) and Alzheimer's Association Guidelines
* Speech frequency pure tone average (0.5- 4 kHz) \>25 db in the better-hearing ear; adult onset hearing loss
* Availability of caregiver/study partner who is 18+ to participate in all study-related visits and who provides care supervision
* Stable (for 2 weeks or longer) dosing of medication (e.g. antidepressants, antipsychotics) for neuropsychiatric symptoms

Exclusion Criteria:

* Current self-reported use of hearing aid or amplification device
* Medical contraindication to use hearing aids ( e.g. draining ears)
* Inability to participate in the 1-month follow up

Primary outcomes:
measure: Distress as assessed by the Neuropsychiatric Inventory (NPI-Q)
timeFrame: Baseline, 6-week, 3-month, and 6-months post-intervention (immediate group). Baseline, 6-week, 3-month, and 6-months post-baseline (Delayed Group)
Secondary outcomes:
measure: Hearing Handicap Inventory for the Elderly (HHIE-S)
timeFrame: Baseline, 6-week, 3-month, and 6-months post-intervention (immediate group). Baseline, 6-week, 3-month, and 6-months post-baseline (Delayed Group)
measure: Relationship Quality as assessed by the Patient-Caregiver Closeness Scale (CG-CR)
timeFrame: Baseline, 6-week, 3-month, and 6-months post-intervention (immediate group). Baseline, 6-week, 3-month, and 6-months post-baseline (Delayed Group)
measure: International Outcome Inventory for Hearing Aids (IOI-HA) Survey
timeFrame: Baseline, 6-week, 3-month, and 6-months post-intervention (immediate group). Baseline, 6-week, 3-month, and 6-months post-baseline (Delayed Group)
Other outcomes:
Locations:
Study officials:
affiliation: Johns Hopkins University
name: Esther Oh, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01048060: Consent for Obtaining Additional Bone Marrow Specimens at Time of Diagnostic Bone Marrow Procedure
Official title: Consent for Obtaining Additional Bone Marrow Specimens at the Time of a Diagnostic Bone Marrow Procedure
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Brain Cancer
Cancer
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2010-01-13
Enrollment: 334
Sex: ALL
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects who are having a bone marrow procedure done as part of their standard oncology work-up will be eligible to be consent on this study.

Brief summary: The purpose of this study is to collect bone marrow samples for experimental studies.


Eligibility criteria: Inclusion Criteria:

* Subjects who are having a bone marrow procedure done as part of their standard oncology work-up will be eligible to be consent on this study.

Exclusion Criteria:

* None.

Primary outcomes:
measure: Cancer Research in Future
timeFrame: 1 time
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University School of Medicine
state: California
Study officials:
affiliation: Stanford University
name: Dr. Neyssa Marina
role: PRINCIPAL_INVESTIGATOR
References: