Clinical trial NCT02604082: Comparison of Three Technical Airway Clearance in Mechanical Ventilated Patients
Official title: Comparison of Three Technical Airway Clearance in Mechanical Ventilated Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mucociliary Clearance Defect
Physical Disability
Lead sponsor: Hospital de Clinicas de Porto Alegre
Sponsor class: OTHER
First posted: 2015-11-13
Enrollment: 93
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Randomized clinical trial, conducted in the Intensive Care Unit of the Hospital de Clinicas de Porto Alegre from october 2011 until november 2015 .

Detailed description: Objective: To compare the effectiveness of techniques: vibrocompression (G1), hyperinflation with mechanical ventilation (G2) vibrocompression + hyperinflation with mechanical ventilation (G3) in the amount of aspirated secretions, mechanical ventilator time, incidence of ventilator-associated pneumonia , reintubation tracheal and mortality in mechanical ventilator. Primary outcome: weight in grams of the aspirated secretions. Secondary outcome: hemodynamic and pulmonary parameters: heart rate, respiratory rate, mean arterial pressure, peripheral arterial oxygen saturation; peak inspiratory pressure, tidal volume; dynamic compliance ; mechanical ventilator time; reintubation tracheal; Incidence of ventilator-associated pneumonia and mortality in mechanical ventilator.

Eligibility criteria: Inclusion Criteria:

* In mechanical ventilation for a period of 24-72 h
* End-expiratory pressure (PEEP) lower 10 cm of water.
* Lower noradrenaline doses of 0.5mg / kg / minute for an average greater than or equal blood outstrips 60 mmHg.

Exclusion Criteria:

* Pneumothorax and hemothorax undrained
* Subcutaneous emphysema
* Osteoporosis
* Acute respiratory distress syndrome - (ARDS)
* Fractures of ribs
* Obese ( BMI greater than 35)
* Mechanical ventilator with higher peak pressures 40 cm of water.

Primary outcomes:
measure: Weight in grams of the pulmonary secretions
timeFrame: up to 24 weeks.
Secondary outcomes:
measure: Time mechanical ventilator (MV) in days
timeFrame: Through study completion, an average of 3 years.
measure: Reintubation tracheal in percentage in the last 24 hours
timeFrame: Through study completion, an average of 3 years.
measure: Incidence of ventilator-associated pneumonia in percentage
timeFrame: Through study completion, an average of 3 years.
measure: Mortality in the MV in percentage
timeFrame: Through study completion, an average of 3 years.
measure: Heart Rate
timeFrame: up to 24 weeks.
measure: Respiratory frequency
timeFrame: up to 24 weeks
measure: Peripheral oxygen saturation in percentage
timeFrame: up to 24 weeks
measure: Tidal volume in milliliters
timeFrame: up to 24 weeks
measure: Peak inspiratory pressure in centimeters of water
timeFrame: up to 24 weeks
Other outcomes:
Locations:
Study officials:
affiliation: HCPorto Alegre, Rio Grande do Sul - Brazil
name: Silvia R Rios Vieira, Dr
role: PRINCIPAL_INVESTIGATOR
References:
citation: Naue Wda S, Forgiarini Junior LA, Dias AS, Vieira SR. Chest compression with a higher level of pressure support ventilation: effects on secretion removal, hemodynamics, and respiratory mechanics in patients on mechanical ventilation. J Bras Pneumol. 2014 Jan-Feb;40(1):55-60. doi: 10.1590/S1806-37132014000100008.