Clinical trial NCT02704468: FGF21 Can Help Predicting Arterial Stiffness Measured by Cardio-ankle Vascular Index in Renal Transplant Patients
Official title: FGF21 Can Help Predicting Arterial Stiffness Measured by Cardio-ankle Vascular Index in Renal Transplant Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Vascular Stiffness
Keywords: CAVI
FGF-21
arterial stiffness
renal transplant
Lead sponsor: Bangkok Metropolitan Administration Medical College and Vajira Hospital
Sponsor class: OTHER_GOV
First posted: 2016-03-10
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: renal transplant pateints for more than 1 month

Brief summary: Chronic kidney disease(CKD) patients have high incidence of coronary artery problems event after renal transplantation. And remain a major cause of mortality. The major risk marker is arterial stiffness. The cardio-ankle vascular index (CAVI) is a new index of overall stiffness and can estimated the risk of atherosclerosis.

Fibroblast growth factor 21 (FGF-21) is a metabolic regulator that plays important role in cardiac remodeling elevated FGF-21 have been reported in coronary heart disease or carotid artery plaque and could be biomarkers for atherosclerosis disease Investigators aimed to study the association between CAVI and FGF-21 and their relations to various parameters that can contribute to cardiovascular disease eg. homocysteine Echocardiogram findings and other traditional basic factors.

Detailed description: A total of 90 participants who underwent renal transplant were included in the study. The following measures were done and laboratory data were collected. CAVI, Ecchocariogram, Homocysteine, Hs-CRP, Carotid IMT, FGF-21, Medication after renal transplantation, incidence of cardiovascular disease correlation between categorical data was done by using Pearson's correlation test and multiple regression analysis.

Eligibility criteria: Inclusion Criteria:

* renal transplant patients patients for more than 1 month

Exclusion Criteria:

* who had contraindication for CAVI
* current smoker
* eGFR \<15 ml/min/173
* cardiac arrthymia

Primary outcomes:
measure: association between CAVI and FGF-21 with arterial stiffness in renal transplant patients
timeFrame: 1 month
Secondary outcomes:
measure: association between Hs-CRP,Homocystein with CAVI
timeFrame: 1 month
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Bangkok metropolitan administraiton of vajira hospital
Study officials:
affiliation: Bangkok metropolitan administration medical college of vajira hospital
name: Thananda Trakarnvanich, M.D.
role: STUDY_DIRECTOR
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