Clinical trial NCT04037410: Environmental Temperature and White Adipose Tissue in Cancer Patients
Official title: Effects of Environmental Temperature on White Adipose Tissue Thermogenic Capacity of Cancer Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cancer Patients
Lead sponsor: University of Thessaly
Sponsor class: OTHER
First posted: 2019-07-30
Enrollment: 202
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cancer patients independently of their disease status

Brief summary: The investigators aimed to retrospectively identify the association between the thermogenic capacity of white adipocytes and the environmental temperature, in cancer patients.

Detailed description: Obesity is characterized by excessive white adipose tissue (WAT) that increases risk for disease. About 700 million adults are obese worldwide, designating the need of reducing excessive WAT in humans and subsequently the risk for disease. For this reason, previous research focused on the thermogenic capacity of white adipocytes in response to cold exposure. Cold exposure represents a main stimulus for increased thermogenic capacity in human white adipocytes, which may have an impact on body weight loss and subsequently on obesity phenomenon.

In a cohort of 202 cancer patients (male=126), who undertook a Positron Emission Tomography (PET/CT), we retrospectively investigated the association between Tenv and thermogenic capacity of subcutaneous WAT (dorsolumbar region near vertebrae L3 and abdominal region). These patients undertook a PET/CT examination in order to define their disease status. They were given instructions in advance to refrain from smoking, exercise and excessive muscle stressors 24-hour prior to their examination. On the day of the measurements they advised to transport themselves by car to the PET/CT Laboratory between 08:00 am to 12 pm, following at least a 6-hour fasting. Patients were first injected an appropriate dose of 18F-FDG (based on their body weight) and then they were remained in a sitting relaxed position within a quiet room of 22-24°C for 60 minutes. Following this period, patients undertook the PET/CT examination, which included on average eight bed positions, while four minutes scanning per bed position was used.

PET/CT imaging analysis for WAT activity (dorsolumbar region near vertebrae L3 and abdominal region) was performed by two independent trained physicians, using previous methodology.

Eligibility criteria: Inclusion Criteria:

* Cancer patients who undertook a PET/CT examination independently of their disease status

Exclusion Criteria:

* Examinations prior to 2016

Primary outcomes:
measure: Assessment of thermogenic capacity of white adipocytes
timeFrame: The SUV of white adipocytes for each patient was measured once via the PET/CT software between 10-30 May 2019.
measure: Environmental temperature
timeFrame: The daily environmental temperature was obtained from Weather Underground (www.wunderground.com) on the 10th May 2019
Secondary outcomes:
Other outcomes:
Locations:
city: Tríkala
country: Greece
facility: Petros Dinas
state: Thessaly
Study officials:
References: