Clinical trial NCT00382382: Diffusion Tensor Imaging in Autism
Official title: Diffusion Tensor Imaging in Autism
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Autistic Disorder
Keywords: Autism
Asperger Syndrome
Restricted repetitive behavior
Stereotyped patterns of behavior
Typically Developing children
Human Volunteers
Lead sponsor: University of Florida
Sponsor class: OTHER
First posted: 2006-09-29
Enrollment: 0
Sex: MALE
Minimum age (years): 8
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Using a new and more detailed approach to diffusion tensor imaging (DTI) recently developed in our lab, the investigators hope to learn more about irregularities in the brain that are related to autism. The investigators are especially interested in brain regions that contribute to repetitive behaviors in children with autism. Repetitive behaviors include stereotyped motor movements (hand-flapping), self-injurious behaviors (head hitting), compulsions (lining up toys), insistence on things staying the same, and difficulty with change. These behaviors often interfere with learning, can disrupt daily functioning, and can lead to other behavioral problems. Two specific aims will be accomplished:

Aim 1: To examine the integrity of white matter pathways in high functioning autistic children. The investigators hypothesize that autism is associated with specific white matter abnormalities in the cerebellum and other motor circuits. Additionally, the investigators expect to confirm and expand on previous reports of cerebral abnormalities by using newly developed DTI methods.

Aim 2: To determine whether there is a relationship between white matter abnormalities and the occurrence of restricted repetitive behaviors in children with autism. The investigators hypothesize that differences in the occurrence and type of restricted repetitive behaviors between autistic individuals are correlated with specific regional white matter abnormalities.

Results from the proposed experiments should contribute to current knowledge of brain abnormalities in autism and their relationship to restricted repetitive behaviors, and may be relevant to understanding the mechanisms underlying motor deficits in this disorder.

Detailed description: Using a new and more detailed approach to diffusion tensor imaging (DTI) recently developed in our lab, the investigators aim to confirm and expand upon previous findings of white matter abnormalities throughout the brain in individuals with autism. The investigators have chosen to focus particularly on cerebellar and motor pathways in consideration of the prevalence of motor deficits in autism as well as brain structural studies that have indicated cerebellar abnormalities in autistic children. Finally, a proposal to investigate a possible functional association between white matter structure and the expression of restricted repetitive behaviors in autistic children, by correlating measures of white matter integrity with behavioral assessments indicating the severity of various forms of restricted repetitive behaviors. Two specific aims will be accomplished. Aim 1: To examine the integrity of white matter pathways in high functioning autistic children. The hypothesis is that autism is associated with specific white matter abnormalities in the cerebellum and other motor circuits. Additionally, it is expect to confirm and expand on previous reports of cerebral abnormalities by using newly developed DTI methods. Aim 2: To determine whether there is a relationship between white matter abnormalities and the occurrence of restricted repetitive behaviors in children with autism. The hypothesis is that differences in the occurrence and type of restricted repetitive behaviors between autistic individuals are correlated with specific regional white matter abnormalities. Results from the proposed experiments should contribute to current knowledge of brain abnormalities in autism and their relationship to restricted repetitive behaviors, and may be relevant to understanding the mechanisms underlying motor deficits in this disorder.

Eligibility criteria: Inclusion Criteria:

* male, aged 8-12 years of age
* clinical diagnoses of autism from a licensed professional for Autism or Asperger's Syndrome
* IQ \>80
* no speech delay
* no major sensory or motor deficits

Exclusion Criteria:

* known genetic or medical conditions (e.g. Fragile X syndrome, tuberous sclerosis, Turner's syndrome)
* currently (within prior 3 months) taking anti-psychotic/dopamine-modulating medications

Primary outcomes:
measure: RBS-R scores, including both total and subset scores
timeFrame: once
Secondary outcomes:
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: McKnight Brain Institute of the University of Florida
state: Florida
Study officials:
affiliation: University of Florida
name: Mark H. Lewis, PhD
role: STUDY_DIRECTOR
References: