louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06966895: The Effectiveness of Parent-child Collaborative Game on Children Attentiveness in Informal Learning Environment
Official title: The Effectiveness of Parent-child Collaborative Game on Children Attentiveness in Informal Learning Environment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Education
Educational Technology
Children
Knowledge
Keywords: informal learning environment
attentiveness
parent-child collaboration
game
Lead sponsor: Shanghai Jiao Tong University School of Medicine
Sponsor class: OTHER
First posted: 2025-05-13
Enrollment: 48
Sex: ALL
Minimum age (years): 8
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: In terms of user motivation, the gamified design model for museums aims to engage and satisfy both parents and children by tapping into their intrinsic and extrinsic motivations. The goal is to enhance their involvement and enjoyment. The model emphasizes social interaction and curiosity, offering opportunities for enjoyment and a sense of accomplishment through interactions with parents and peers. By incorporating game-like challenges, the model caters to children\&amp;amp;amp;#39;s natural inclination for exploration, igniting their curiosity and thus increasing their interest and engagement with the museum.
Primary purpose: OTHER

Brief summary: To assess the impact of applying a parent-child collaboration game app on children during museum visiting process compared to traditional text-based panels.

Detailed description: The objective of our research was to confirm the efficacy of an interactive app that facilitates parent-child collaboration during museum visits and to provide children with knowledge regarding the museum learning process. An application is utilized throughout the entire behavioral process of a museum visit; it serves as an auxiliary tool to facilitate the parent-child experience in the museum in a more targeted manner.

Eligibility criteria: Inclusion Criteria:

1. age 8-10 years,
2. good communication and comprehension skills without significant cognitive deficits
3. parents\&#39; ability to operate electronic devices proficiently.

Exclusion Criteria:

1. children can't read the text accurately
2. children with severe disabilities who are unable to move easily
3. guardians who are responsible for more than one child

Primary outcomes:
measure: FSS (Flow State Scale) score
timeFrame: immediately after the procedure
Secondary outcomes:
measure: Post-game knowledge assessment
timeFrame: immediately after the procedure
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Jiao Tong University
state: Shanghai
Study officials:
affiliation: Shanghai Jiao Tong University School of Medicine
name: Dian Zhu
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04615195: Effect of COVID-19 Related COntainment in ChildreN
Official title: Effect of COVID-19 Related COntainment in ChildreN
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Post Traumatic Stress Disorder
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2020-11-04
Enrollment: 703
Sex: ALL
Minimum age (years): 8
Maximum age (years): 15
Standard ages: CHILD
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All children aged between 8 and 15 accepting to participate and whose parents accepting to particpate

Brief summary: The current pandemic situation (SRAS COV2) is an unprecedented event and a source of stress potentially aggravated by containment. The Child Revised Impact Event Scale (CRIES-13) was evaluated in children 8 years or older in survivors of traumatic events, flood, stay in intensive care, or war (Bosnia). In this study CRIES-13 will be used to determine the prevalence of precursor signs of post-traumatic stress in children aged 8 to 15 confined between March 17, 2020 and May 2020

Detailed description: Parents of children aged 8 to 15 will be approached from different levels / places of selection / recruitment. A clinical researcher of pediatric clinical investigation center will collect the responses.

If one of the holders of parental authority and the child agree to participate, an information notice will be sent to them, then they will be contacted by telephone by a clinical research assistant to answer the questionnaire.

In large families, the CRIES-13 of the holder of parental authority and of the child will be applied for each of them whose age corresponds to the inclusion criteria.

The duration of the study / participant call and effective response to the questionnaire by the holder of parental authority and the child will takes a maximum of 20 minutes.

Eligibility criteria: Inclusion Criteria:

* Binomial of child (aged between 8 and 15) and one of its holders of parental authority agreeing to participate

Exclusion Criteria:

* children aged under 8 and over 15
* children whose parents are opposed
* children refusing to participate
* holders of minor parental authority

Primary outcomes:
measure: Signs of post traumatic stress disorder
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Toulouse
country: France
facility: UHToulouse
Study officials:
affiliation: University Hospital, Toulouse
name: Isabelle Claudet, Pr
role: PRINCIPAL_INVESTIGATOR
References:
citation: Claudet I, Marchand-Tonel C, Ricco L, Houze-Cerfon CH, Lang T, Brehin C. During the COVID-19 Quarantine, Home Has Been More Harmful Than the Virus for Children! Pediatr Emerg Care. 2020 Sep;36(9):e538-e540. doi: 10.1097/PEC.0000000000002205. No abstract available.
citation: Claudet I, Marchand-Tonel C, Kelly-Irving M, Gaudron CZ, Raynaud JP, Delpierre C, Brehin C. The psychological effects of COVID-19-related containment in children: The E-COCCON French study. Arch Pediatr. 2022 Apr;29(3):188-193. doi: 10.1016/j.arcped.2022.01.011. Epub 2022 Jan 19.
Clinical trial NCT00344695: Bupropion Treatment for Youth Smoking Cessation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Nicotine Dependence
Lead sponsor: University of Arizona
Sponsor class: OTHER
First posted: 2006-06-27
Sex: ALL
Minimum age (years): 14
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to 1) evaluate the safety and efficacy of two doses of bupropion SR (150mg/day and 300mg/day) when compared to placebo, as an aid to smoking cessation in adolescents and 2) to examine which factors, such as medication adherence, nicotine dependence, and motivation to quit, affect treatment outcome.


Eligibility criteria: Inclusion Criteria:

* 14 to 17 years of age
* Smoked at least 6 cigarettes per day
* Exhaled CO greater than or equal to 10 ppm
* Made at least two previous quit attempts
* Weighed at least 90 pounds
* Able to read English at least the 6th grade level
* Motivated to quit smoking as evidenced by willingness to commit to study protocol requirements for the duration of the study
* provided active parental consent and youth assent

Exclusion Criteria:

* Current use of tobacco products other than cigarettes, unless willing to abstain from these products for the study duration
* Current use of other treatments for smoking cessation
* History or current diagnosis of panic disorder, psychosis, bipolar disorder, or eating disorder
* History of abuse or dependence on alcohol or other recreational or prescription drugs in the three months preceding the study
* Current evidence of clinical depression or Attention Deficit/Hyperactivity Disorder
* Use of any psychoactive drug and/or any type of antidepressant with in four weeks of the treatment phase of the study
* Predisposition to seizure or tic disorders or a personal history of a seizure disorder, family history of seizure disorders, or treatment with medication or therapies that increase the risk of seizures
* Significant history of or current clinical evidence of cardiovascular disease
* (Females)Pregnancy (urine pregnancy test), lactation or, if sexually active, unwillingness to use a medically acceptable form of contraception for the duration of the study
* Only one member of a household was allowed to participate in the study concurrently.

Primary outcomes:
measure: Biochemically verified 7 day point prevalence abstinence from smoking.
Secondary outcomes:
Other outcomes:
Locations:
city: Tucson
country: United States
facility: University of Arizona
state: Arizona
Study officials:
affiliation: University of Arizona
name: Myra L. Muramoto, MD MPH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Muramoto ML, Leischow SJ, Sherrill D, Matthews E, Strayer LJ. Randomized, double-blind, placebo-controlled trial of 2 dosages of sustained-release bupropion for adolescent smoking cessation. Arch Pediatr Adolesc Med. 2007 Nov;161(11):1068-74. doi: 10.1001/archpedi.161.11.1068.
Clinical trial NCT05055895: Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia:
Official title: Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia: A Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Delirium
Anticholinergic Adverse Reaction
Alzheimer Disease
Lead sponsor: Gulhane Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2021-09-24
Enrollment: 450
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All participiants enrolled from outpaitent clinic and underwent by comprehesive geriatric asssessment.

Delirium and dementia status was assessed by the criteria of confusion assessment method (CAM) and DSM-4 or DSM-5 respectively.

Brief summary: Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects. However, limited data are available concerning their contribution to time of onset of delirium. This study aimed to determine the potential association of higher anticholinergic burden to early-onset of delirium superimposed dementia in the older adult.


Eligibility criteria: Inclusion Criteria:

* 65 years and older and diagnosis or fellow-up of Alzhemier dementia in outpatient clinic.

Exclusion Criteria:

* The patients with a history of other than Alzhemier dementia or neurodegenerative disease (epilepsy, multiple sclerosis, Parkinson disease, etc.), terminal illness (malignancy, advanced organ failure) were excluded.

Primary outcomes:
measure: Time onset of delirium superimposed dementia
timeFrame: 12 month
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gulhane training and research hospital
Study officials:
References:
Clinical trial NCT01521195: Oxygen Consumption In Critically Ill Children
Official title: A Pilot Study of the Relationship Between Oxygen Delivery and Consumption During Extracorporeal Membrane Oxygenation.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Extracorporeal Membrane Oxygenation
Keywords: pediatric
ECMO
extracorporeal blood flow
VO2
Lead sponsor: The Hospital for Sick Children
Sponsor class: OTHER
First posted: 2012-01-30
Enrollment: 11
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The investigators propose to examine the relationship between DO2 and VO2 in critically ill patients requiring an Extracorporeal Membrane Oxygenation (ECMO) machine. This machine can provide complete support of heart and lung function. In so doing, the investigators will be able to avoid physiologic coupling by increasing DO2 mechanically, by increasing blood flow through the ECMO circuit.

Null Hypothesis:

Increased oxygen delivery, by means of an increased rate of extracorporeal blood flow, is not associated with an increase in oxygen consumption.

Alternate Hypothesis:

Increased oxygen delivery, by means of an increased rate of extracorporeal blood flow, is associated with an increase in oxygen consumption.


Eligibility criteria: Inclusion Criteria:

* Patients in the Critical Care Unit on veno-arterial ECMO.
* Hemodynamic stability established, as adjudged by the treating CCU staff physician.
* Informed consent by parent or legal guardian.
* Approval by treating CCU staff physician to approach parents/guardians for consent process at any given time.

Exclusion Criteria:

* Patients in the Critical Care Unit on veno-venous (VV) ECMO.
* Inability to tolerate study period without red cell transfusion.
* Presence of a large leak around the endotracheal tube (\> 10% tidal volume).
* Patients requiring \> 70 % FiO2 at the time of potential enrollment.
* Parent or legal guardian refuse consent.

Primary outcomes:
measure: Oxygen consumption (VO2)
timeFrame: Baseline
measure: Oxygen consumption (VO2)
timeFrame: 30min
measure: Oxygen consumption (VO2)
timeFrame: 60min
measure: Oxygen consumption (VO2)
timeFrame: 90min
Secondary outcomes:
measure: Arterial serum lactate level
timeFrame: Baseline, 30min, 60min, 90min
measure: Oxygen extraction ratio.
timeFrame: Baseline, 30min, 60min, 90min
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: The Hospital for Sick Children
state: Ontario
Study officials:
affiliation: The Hospital for Sick Children
name: Brian Kavanagh, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tosoni A, La Rotta G, Breatnach C, Anand V, Foreman C, Davidson L, Redington AN, Kavanagh BP. Oxygen Delivery and Consumption Are Independent: Evidence from Venoarterial Extracorporeal Membrane Oxygenation in Resuscitated Children. Am J Respir Crit Care Med. 2015 Sep 15;192(6):765-7. doi: 10.1164/rccm.201502-0267LE. No abstract available.
Clinical trial NCT03573895: Stretching vs Foam-rolling
Official title: Comparison of Acute Effects of Stretching and Foam-rolling
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Relaxation
Lead sponsor: Universitat Internacional de Catalunya
Sponsor class: OTHER
First posted: 2018-06-29
Enrollment: 94
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study aims to compare the acute effects of the aplication of foam-rolling and stretching over the hamstrings flexibility.

The secondary objective is to determine which time can permit the obtention of better results.


Eligibility criteria: Exclusion Criteria:

* Pregnant women
* Musculoskeletal disorder in the last 3 months
* Surgical interventions in lower limbs in the last 6 months
* Psychological or nervous alterations
* Uncomprehension of the indications.

Primary outcomes:
measure: Hamstring flexibility change
timeFrame: 0 seconds, 30 seconds and 2 minutes
Secondary outcomes:
measure: Triceps surae flexibility change
timeFrame: 0 seconds, 30 seconds and 2 minutes
measure: Fatigue perception
timeFrame: 0 seconds, 30 seconds and 2 minutes
Other outcomes:
Locations:
city: Sant Cugat Del Vallès
country: Spain
facility: Universitat Internacional de Catalunya
state: Barcelona
Study officials:
affiliation: Anatomy lecturer
name: Albert Pérez-Bellmunt, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01618981: LEft Atrial Pacing in Diastolic Heart Failure
Official title: LEft Atrial Pacing in Diastolic Heart Failure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Failure With Preserved Ejection Fraction
Atrial Dyssynchrony Syndrome
Left Atrio-ventricular Asynchrony
Keywords: Heart failure with preserved ejection fraction
atrial dyssynchrony syndrome
left atrio-ventricular asynchrony
pacemaker
left atrial pacing therapy
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2012-06-14
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: The purpose of this study is to assess left atrial pacing therapy in patients with atrial dyssynchrony syndrome and heart failure with preserved ejection fraction.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 65
* Sinus rhythm, PR \< 220ms, QRS \< 110ms
* Heart failure (NYHA class III-IV or II with hospitalization for heart failure)
* Ejection Fraction \> 50%, restrictive mitral inflow, Lateral E/e' \> 12 or septal E/e' \> 15, Left atrial index volume \> 34 ml/m²
* Atrial dyssynchrony syndrome: (TTE) inter-atrial time delay ≥ 70ms (difference between tricuspid and mitral P-A intervals or between mitral and tricupsid P-A' intervals with DTI)
* Left atrio-ventricular asynchrony: Time Difference between tricupsid and mitral A wave duration ≥ 35ms.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Dijon
country: France
facility: CHU Dijon
Study officials:
References:
Clinical trial NCT04469881: Netflix Streaming Services in the Operating Room During Total Knee Replacement - a Feasibility Study
Official title: Netflix Streaming Services in the Operating Room During Total Knee Replacement - a Feasibility Study
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Surgery
Lead sponsor: Virginia Commonwealth University
Sponsor class: OTHER
First posted: 2020-07-14
Enrollment: 3
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The purpose of this research study is to test the safety, tolerability, and effectiveness of watching streamed videos through virtual reality (VR) goggles during surgery.

The results of this study will be used to evaluate whether video-streaming services on VR goggles are worthwhile additions to standard anesthesia care during total knee surgery.

Detailed description: Usual anesthetic care for total knee replacement involves intravenous sedation as well as spinal anesthesia. In this study, participants will receive usual care, and in addition, will be asked to wear VR goggles once they arrive in the operating room. Participants will choose from a selection of 10 shows and movies to watch for the duration of the surgery (approximately 2 hours).

Eligibility criteria: Inclusion Criteria:

1. undergoing a primary elective total knee replacement by one of the orthopedic joint surgeons at Virginia Commonwealth University Medical Center
2. 18 years of age or older
3. eligible for spinal anesthesia
4. mentally capable of understanding instructions on how to request anesthesia medication

Exclusion Criteria:

1. identified as a member of regulated vulnerable population
2. ineligibility for spinal anesthesia
3. morbid obesity (body mass index greater than 40)
4. allergy to propofol or midazolam
5. pre-operative daily opioid consumption of more than 10 mg oxycodone every 6 hours (over 60 morphine miligram equivalents per day)
6. daily benzodiazepine consumption
7. history of alcohol or recreational drug abuse
8. hearing or visually impaired individuals

Primary outcomes:
measure: Sedation requirement
timeFrame: approximately 2 hours
Secondary outcomes:
measure: Participant pain rating
timeFrame: 24 hours
measure: Opioid consumption
timeFrame: 24 hours
measure: Time to first opioid request
timeFrame: up to 24 hours
Other outcomes:
Locations:
city: Richmond
country: United States
facility: Virginia Commonwealth University
state: Virginia
Study officials:
affiliation: Virginia Commonwealth University
name: Bryant Tran, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02437981: Evaluation of PrEP-30: a Demonstration Project of Pre-exposure Prophylaxis for MSM and Other High-risk Group Clients at the Thai Red Cross Anonymous Clinic
Official title: Thai Red Cross AIDS Research Centre (TRC-ARC)
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: HIV Prevention
Lead sponsor: Thai Red Cross AIDS Research Centre
Sponsor class: OTHER
First posted: 2015-05-08
Enrollment: 20000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: MSM and other individuals at risk for HIV infection

Brief summary: PrEP-30 is a demonstration project to assess the feasibility of providing oral PrEP to MSM and other individuals at-risk for HIV in Bangkok, Thailand as a service that is funded entirely through user fees. Tenofovir disoproxil fumarate/emtricitabine PrEP is provided part of a combined HIV prevention program that includes risk-reduction counseling, regular HIV testing, and the provision of condoms and lubricants. PrEP-30 is implemented at the Thai Red Cross AIDS Research Centre, at the site of the largest HIV counseling and testing center in Thailand.


Eligibility criteria: Inclusion Criteria:

1. Age \> 18 years
2. HIV test negative
3. Creatinine clearance \> 60 ml/min
4. No contraindication or allergy to PrEP medications (TDF/FTC)
5. At least one risk factor for HIV infection within the previous 6 months:

   * sex partner known to be HIV positive
   * works as commercial sex worker
   * use of PEP for sexual exposure
   * injection drug use
   * any STI (syphilis, gonorrhea, chlamydia)
   * \> 5 sex partners
   * inconsistent condom use with high-risk partners, including MSM, IDU

     * MSM: any insertive or receptive anal sex without condom
     * Women: any sex without condom with high-risk male partner (MSM, IDU, multiple female partners)
     * Heterosexual men: any sex without condom with high-risk female partner (commercial sex worker, IDU, multiple male partners)

Exclusion Criteria: -

Primary outcomes:
measure: Primary outcome measures:
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Thai Red Cross AIDS Research Centre
state: Pathumwan
Study officials:
References: