Clinical trial NCT04929795: Effects of Music Beat on Motor Function in Individuals At Risk for Psychotic Onset and Schizophrenia Patients
Official title: Effects of Music Beat on Motor Function in Individuals At Risk for Psychotic Onset and Schizophrenia Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Schizophrenia
Psychosis
Parkinsonism
Dyskinesias
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
First posted: 2021-06-18
Enrollment: 15
Sex: ALL
Minimum age (years): 13
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this project is to investigate whether a 3-week training program involving music beat (serving as a type of rhythmic auditory stimulation) reduces the severity of bradykinesia and dyskinesia in at-risk individuals and schizophrenia patients. It is hypothesized that the program is effective in reducing the severity of bradykinesia and dyskinesia in at-risk individuals and schizophrenia patients.


Eligibility criteria: For at-risk participants:

Inclusion criteria:

1. A score of or above 9 in the Chinese version of the 16-item Prodromal Questionnaire (CPQ-16), or a score of or above 8.18 in the Chinese version of Community Assessment of Psychic Experiences with 15 items (CAPE-C15), or a score of or above 17 in Schizotypal Personality Questionnaire-Brief (SPQ-B);
2. an age of 13 years or above;
3. score \> 60 in The Chinese version of Edinburgh Handedness Inventory (CH-EBI) to ensure right handedness; and
4. score ≥ 22 in Montreal Cognitive Assessment Hong Kong Version (HK-MoCA) to ensure no serious cognitive deficits so that they can understand instructions.

Exclusion criteria:

1. psychiatric diagnosis by self-report;
2. cardiovascular, neurological, muscular or orthopedic diseases that may affect hand movements;
3. taking psychiatric medications;
4. substance abuse; and
5. being pregnant.

For schizophrenia participants:

Inclusion criteria:

1. a diagnosis of schizophrenia without other psychiatric diseases;
2. the age ≥ 18 years;
3. score \> 60 in CH-EBI to ensure right handedness; and
4. score ≥ 22 in HK-MoCA to ensure no serious cognitive deficits so that they can understand instructions.

Exclusion criteria:

1. cardiovascular, neurological, muscular or orthopedic diseases that may affect hand movements;
2. substance abuse; and
3. being pregnant.

Primary outcomes:
measure: Motion analysis by using an eight-camera motion capture system (VICON; Oxford Metrics Group, Oxford, UK)
timeFrame: Within one week right before the 1st session of the intervention
measure: Motion analysis by using an eight-camera motion capture system (VICON; Oxford Metrics Group, Oxford, UK)
timeFrame: Within one week right after the last session of the intervention
measure: Motion analysis by using an eight-camera motion capture system (VICON; Oxford Metrics Group, Oxford, UK)
timeFrame: Within one week right before the 1st session of the intervention
measure: Motion analysis by using an eight-camera motion capture system (VICON; Oxford Metrics Group, Oxford, UK)
timeFrame: Within one week right after the last session of the intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Kowloon
country: Hong Kong
facility: ST814, the Hong Kong Polytechnic University
Study officials:
References: