Clinical trial NCT00857012: Arimidex: Compliance and Arthralgias in Clinical Therapy (COMPACT)
Official title: Arimidex: Compliance and Arthralgias in Clinical Therapy (COMPACT): An in Practice Assessment of Arthralgias and Related Costs as Well as Compliance in the First Year of Anastrozole Therapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Breast Cancer
Keywords: Primary early MCa
Arimidex
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2009-03-06
Enrollment: 2313
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The patient population will include postmenopausal women with hormone-receptor positive primary breast cancer receiving adjuvant endocrine treatment with anastrozole upfront or following two to three years of tamoxifen therapy ("switch") according to the current SmPC (Appendix C). Patients will have received anastrozole treatment for at least 3 months and up to 6 months before the start of the study.

Brief summary: Patients are eligible for inclusion in this NIS if they have taken anastrozole either upfront or following two to three years of tamoxifen treatment ("switch") for at least three and not more than six months prior to offering an individual participation in this program. Treatment should follow local therapy guidelines and standard practice. Treatment decisions for patients participating in this study including assessments or supportive therapy during follow-up visits will also follow guidelines and remain independent of the program.

Detailed description: The patient population will include postmenopausal women with hormone-receptor positive primary breast cancer scheduled for adjuvant upfront endocrine treatment with anastrozole or following two to three years of tamoxifen treatment ("switch") according to the current SmPC (Appendix C). Patients will have taken anastrozole for at least three months and not more than six months before the start of the study.

Eligibility criteria: Inclusion Criteria:

* Postmenopausal women aged 18 years or older; Postmenopause is defined as Natural menopause with menses \>1 year ago or Serum FSH (\> 20 IU/ l), and E2 levels in the postmenopausal range or patients who had bilateral oophorectomy
* Histologically / cytologically confirmed primary diagnosis of early breast cancer (M0) with hormone sensitive tumour (ER+ve and/or PgR+ve)
* Patients, who underwent breast cancer surgery and, if appl. radiation therapy and/or neo/adjuvant chemotherapy and have taken adjuvant endocrine treatment with anastrozole (upfront or following two to three years of tamoxifen) min 3 max 6 months
* In case of a previous therapy with tamoxifen (switch-therapy), duration of tamoxifen treatment for at least two and up to three years.

Exclusion Criteria:

* Patients with severe renal function disorders (Creatinine clearance \< 20 ml/min or Patients with moderate or severe disorders of hepatic function
* Concomitant treatment with drugs known to affect sex hormonal status and tamoxifen
* Patients with ductal carcinoma in situ (DCIS) without primary diagnosis of early breast cancer (M0)
* Evidence of any significant clinical disorder or laboratory finding which in the opinion of the investigator, makes it undesirable for the patient to participate in the program

Primary outcomes:
measure: Assessment of arthralgia scores and patients' compliance within the first year of anastrozole treatment, stratified by upfront and switch therapy as well as assessment of the relationship between compliance and arthralgia scores.
timeFrame: 12 months
Secondary outcomes:
measure: Incidence of arthralgia and arthralgia characteristics within the 1st year of anastrozole therapy stratified by upfront and switch therapy and assessment of the relationship of arthralgia incidence and arthralgia characteristics to patients compliance.
timeFrame: 12 months
measure: Retrospective assessment of incidence of pre-existing arthralgias before start of anastrozole treatment, stratified by upfront and switch therapy.
timeFrame: 12 months
measure: Descriptive assessment of arthralgia therapy and of costs of arthralgia therapy, stratified by upfront and switch therapy.
timeFrame: 12 months
measure: Identification of factors influencing and correlating to treatment-emergent arthralgias
timeFrame: 12 months
measure: Assessment of safety and tolerability of anastrozole.
timeFrame: 12 months
Other outcomes:
Locations:
city: Aachen
country: Germany
facility: Research Site
city: Aalen
country: Germany
facility: Research Site
city: Ahaus
country: Germany
facility: Research Site
city: Albstadt
country: Germany
facility: Research Site
city: Altotting
country: Germany
facility: Research Site
city: Alzey
country: Germany
facility: Research Site
city: Amberg
country: Germany
facility: Research Site
city: Apolda
country: Germany
facility: Research Site
city: Aschaffenburg
country: Germany
facility: Research Site
city: Aschersleben
country: Germany
facility: Research Site
city: Augsburg
country: Germany
facility: Research Site
city: Aurich
country: Germany
facility: Research Site
city: Babenhausen
country: Germany
facility: Research Site
city: Bad Durkheim
country: Germany
facility: Research Site
city: Bad Herrenalb
country: Germany
facility: Research Site
city: Bad Nauheim
country: Germany
facility: Research Site
city: Bad Neuenahr-Ahrweiler
country: Germany
facility: Research Site
city: Bad Oeynhausen
country: Germany
facility: Research Site
city: Bad Oldesloe
country: Germany
facility: Research Site
city: Bad Reichenhall
country: Germany
facility: Research Site
city: Bad Saarow
country: Germany
facility: Research Site
city: Bad Segeberg
country: Germany
facility: Research Site
city: Bad Tolz
country: Germany
facility: Research Site
city: Bad Urach
country: Germany
facility: Research Site
city: Bad Wildbad
country: Germany
facility: Research Site
city: Bad Wildungen
country: Germany
facility: Research Site
city: Bad Windsheim
country: Germany
facility: Research Site
city: Baden-Baden
country: Germany
facility: Research Site
city: Bamberg
country: Germany
facility: Research Site
city: Bautzen
country: Germany
facility: Research Site
city: Bayreuth
country: Germany
facility: Research Site
city: Berlin-Kreuzberg
country: Germany
facility: Research Site
city: Berlin-Steglitz
country: Germany
facility: Research Site
city: Berlin
country: Germany
facility: Research Site
city: Bexbach
country: Germany
facility: Research Site
city: Biberach
country: Germany
facility: Research Site
city: Biedenkopf
country: Germany
facility: Research Site
city: Bielefeld
country: Germany
facility: Research Site
city: Bietigheim-Bissingen
country: Germany
facility: Research Site
city: Blankenburg
country: Germany
facility: Research Site
city: Blumberg in Baden
country: Germany
facility: Research Site
city: Boblingen
country: Germany
facility: Research Site
city: Bocholt
country: Germany
facility: Research Site
city: Bochum
country: Germany
facility: Research Site
city: Bonn
country: Germany
facility: Research Site
city: Borna
country: Germany
facility: Research Site
city: Bottrop
country: Germany
facility: Research Site
city: Brackenheim
country: Germany
facility: Research Site
city: Bramsche
country: Germany
facility: Research Site
city: Brandenburg
country: Germany
facility: Research Site
city: Braunschweig
country: Germany
facility: Research Site
city: Bretten
country: Germany
facility: Research Site
city: Bruchsal
country: Germany
facility: Research Site
city: Bruhl
country: Germany
facility: Research Site
city: Buhl
country: Germany
facility: Research Site
city: Bunde
country: Germany
facility: Research Site
city: Burghausen
country: Germany
facility: Research Site
city: Burg
country: Germany
facility: Research Site
city: Celle
country: Germany
facility: Research Site
city: Chemnitz
country: Germany
facility: Research Site
city: Cloppenburg
country: Germany
facility: Research Site
city: Coburg
country: Germany
facility: Research Site
city: Coesfeld
country: Germany
facility: Research Site
city: Dachau
country: Germany
facility: Research Site
city: Damme
country: Germany
facility: Research Site
city: Datteln
country: Germany
facility: Research Site
city: Demmin
country: Germany
facility: Research Site
city: Dessau-Rosslau
country: Germany
facility: Research Site
city: Dessau
country: Germany
facility: Research Site
city: Diessen
country: Germany
facility: Research Site
city: Dillenburg
country: Germany
facility: Research Site
city: Dillingen
country: Germany
facility: Research Site
city: Dinkelsbuhl
country: Germany
facility: Research Site
city: Ditzingen
country: Germany
facility: Research Site
city: Doberlug-Kirchhain
country: Germany
facility: Research Site
city: Dornstadt
country: Germany
facility: Research Site
city: Dorsten
country: Germany
facility: Research Site
city: Dortmund
country: Germany
facility: Research Site
city: Dreieich
country: Germany
facility: Research Site
city: Dresden
country: Germany
facility: Research Site
city: Duisburg
country: Germany
facility: Research Site
city: Duren
country: Germany
facility: Research Site
city: Dusseldorf
country: Germany
facility: Research Site
city: Ebermannstadt
country: Germany
facility: Research Site
city: Ebersbach
country: Germany
facility: Research Site
city: Eggenfelden
country: Germany
facility: Research Site
city: Eisenach
country: Germany
facility: Research Site
city: Ellwangen
country: Germany
facility: Research Site
city: Elmshorn
country: Germany
facility: Research Site
city: Emmendingen
country: Germany
facility: Research Site
city: Erding
country: Germany
facility: Research Site
city: Erfurt
country: Germany
facility: Research Site
city: Ergolding
country: Germany
facility: Research Site
city: Erkelenz
country: Germany
facility: Research Site
city: Eschweiler
country: Germany
facility: Research Site
city: Esens
country: Germany
facility: Research Site
city: Essen
country: Germany
facility: Research Site
city: Ettlingen
country: Germany
facility: Research Site
city: Euskirchen
country: Germany
facility: Research Site
city: Eutin
country: Germany
facility: Research Site
city: Feuchtwangen
country: Germany
facility: Research Site
city: Flensburg
country: Germany
facility: Research Site
city: Frankenberg
country: Germany
facility: Research Site
city: Frankenthal
country: Germany
facility: Research Site
city: Frankfurt (Oder)
country: Germany
facility: Research Site
city: Frechen
country: Germany
facility: Research Site
city: Freiburg
country: Germany
facility: Research Site
city: Freising
country: Germany
facility: Research Site
city: Freital
country: Germany
facility: Research Site
city: Freyung
country: Germany
facility: Research Site
city: Friedrichshafen
country: Germany
facility: Research Site
city: Fulda
country: Germany
facility: Research Site
city: Furstenfeldbruck
country: Germany
facility: Research Site
city: Furstenwalde
country: Germany
facility: Research Site
city: Furth
country: Germany
facility: Research Site
city: Garbsen
country: Germany
facility: Research Site
city: Geesthacht
country: Germany
facility: Research Site
city: Geilenkirchen
country: Germany
facility: Research Site
city: Gelsenkirchen
country: Germany
facility: Research Site
city: Georgsmarienhutte
country: Germany
facility: Research Site
city: Gera
country: Germany
facility: Research Site
city: Geretsried
country: Germany
facility: Research Site
city: Gerlingen
country: Germany
facility: Research Site
city: Gersthofen
country: Germany
facility: Research Site
city: Giesen
country: Germany
facility: Research Site
city: Gifhorn
country: Germany
facility: Research Site
city: Gladbeck
country: Germany
facility: Research Site
city: Goppingen
country: Germany
facility: Research Site
city: Goslar
country: Germany
facility: Research Site
city: Gottingen
country: Germany
facility: Research Site
city: Grafelfing
country: Germany
facility: Research Site
city: Griesheim
country: Germany
facility: Research Site
city: Gummersbach
country: Germany
facility: Research Site
city: Gunzburg
country: Germany
facility: Research Site
city: Gustrow
country: Germany
facility: Research Site
city: Haiger
country: Germany
facility: Research Site
city: Halberstadt
country: Germany
facility: Research Site
city: Halle / Saale
country: Germany
facility: Research Site
city: Halle
country: Germany
facility: Research Site
city: Hamburg
country: Germany
facility: Research Site
city: Hameln
country: Germany
facility: Research Site
city: Hamm
country: Germany
facility: Research Site
city: Hannover
country: Germany
facility: Research Site
city: Hartha
country: Germany
facility: Research Site
city: Heidelberg
country: Germany
facility: Research Site
city: Heidenheim
country: Germany
facility: Research Site
city: Heide
country: Germany
facility: Research Site
city: Heilbronn
country: Germany
facility: Research Site
city: Heinsberg
country: Germany
facility: Research Site
city: Hemmingen
country: Germany
facility: Research Site
city: Henstedt-Ulzburg
country: Germany
facility: Research Site
city: Heppenheim
country: Germany
facility: Research Site
city: Herborn
country: Germany
facility: Research Site
city: Herbrechtingen
country: Germany
facility: Research Site
city: Herdecke
country: Germany
facility: Research Site
city: Herford
country: Germany
facility: Research Site
city: Hermsdorf
country: Germany
facility: Research Site
city: Herne
country: Germany
facility: Research Site
city: Herzberg am Harz
country: Germany
facility: Research Site
city: Herzberg
country: Germany
facility: Research Site
city: Hessisch Oldendorf
country: Germany
facility: Research Site
city: Hilchenbach
country: Germany
facility: Research Site
city: Hildesheim
country: Germany
facility: Research Site
city: Hillesheim
country: Germany
facility: Research Site
city: Hochstadt
country: Germany
facility: Research Site
city: Hofheim
country: Germany
facility: Research Site
city: Hof
country: Germany
facility: Research Site
city: Holzminden
country: Germany
facility: Research Site
city: Homburg/Saar
country: Germany
facility: Research Site
city: Huckelhoven
country: Germany
facility: Research Site
city: Ilsede
country: Germany
facility: Research Site
city: Ingolstadt
country: Germany
facility: Research Site
city: Isny
country: Germany
facility: Research Site
city: Itzehoe
country: Germany
facility: Research Site
city: Jena
country: Germany
facility: Research Site
city: Kahla
country: Germany
facility: Research Site
city: Kalkar
country: Germany
facility: Research Site
city: Karlsbad
country: Germany
facility: Research Site
city: Karlsruhe
country: Germany
facility: Research Site
city: Kassel
country: Germany
facility: Research Site
city: Kaufbeuren
country: Germany
facility: Research Site
city: Kempten
country: Germany
facility: Research Site
city: Kerpen
country: Germany
facility: Research Site
city: Kiel
country: Germany
facility: Research Site
city: Koblenz
country: Germany
facility: Research Site
city: Koln
country: Germany
facility: Research Site
city: Konigs Wusterhausen
country: Germany
facility: Research Site
city: Konstanz
country: Germany
facility: Research Site
city: Korntal-Munchingen
country: Germany
facility: Research Site
city: Krefeld
country: Germany
facility: Research Site
city: Kreuztal
country: Germany
facility: Research Site
city: Krumbach
country: Germany
facility: Research Site
city: Kunzelsau
country: Germany
facility: Research Site
city: Kusel
country: Germany
facility: Research Site
city: Laatzen
country: Germany
facility: Research Site
city: Lahnstein
country: Germany
facility: Research Site
city: Landau
country: Germany
facility: Research Site
city: Landshut
country: Germany
facility: Research Site
city: Langenhagen
country: Germany
facility: Research Site
city: Langen
country: Germany
facility: Research Site
city: Lauf
country: Germany
facility: Research Site
city: Lehrte
country: Germany
facility: Research Site
city: Leichlingen
country: Germany
facility: Research Site
city: Leipzig
country: Germany
facility: Research Site
city: Leisnig
country: Germany
facility: Research Site
city: Leonberg
country: Germany
facility: Research Site
city: Leverkusen
country: Germany
facility: Research Site
city: Lich
country: Germany
facility: Research Site
city: Limburg
country: Germany
facility: Research Site
city: Lingen
country: Germany
facility: Research Site
city: Lobau
country: Germany
facility: Research Site
city: Lohsa OT Weisskollm
country: Germany
facility: Research Site
city: Lubeck
country: Germany
facility: Research Site
city: Ludwigsfelde
country: Germany
facility: Research Site
city: Ludwigshafen
country: Germany
facility: Research Site
city: Luneburg
country: Germany
facility: Research Site
city: Lunen
country: Germany
facility: Research Site
city: Magdeburg
country: Germany
facility: Research Site
city: Mannheim
country: Germany
facility: Research Site
city: Marburg
country: Germany
facility: Research Site
city: Marienheide
country: Germany
facility: Research Site
city: Markranstadt
country: Germany
facility: Research Site
city: Marktredwitz
country: Germany
facility: Research Site
city: Marl
country: Germany
facility: Research Site
city: Mayen
country: Germany
facility: Research Site
city: Meiningen
country: Germany
facility: Research Site
city: Meissen
country: Germany
facility: Research Site
city: Memmingen
country: Germany
facility: Research Site
city: Mendig
country: Germany
facility: Research Site
city: Mettingen
country: Germany
facility: Research Site
city: Metzingen
country: Germany
facility: Research Site
city: Minden
country: Germany
facility: Research Site
city: Mittweida
country: Germany
facility: Research Site
city: Moers
country: Germany
facility: Research Site
city: Monchengladbach
country: Germany
facility: Research Site
city: Muhldorf
country: Germany
facility: Research Site
city: Muhlhausen
country: Germany
facility: Research Site
city: Muhlheim
country: Germany
facility: Research Site
city: Mulheim a. d. Ruhr
country: Germany
facility: Research Site
city: Munchen
country: Germany
facility: Research Site
city: Munster
country: Germany
facility: Research Site
city: Mutlangen
country: Germany
facility: Research Site
city: Nauen
country: Germany
facility: Research Site
city: Naunhof
country: Germany
facility: Research Site
city: Neckarsulm
country: Germany
facility: Research Site
city: Netphen
country: Germany
facility: Research Site
city: Neubrandenburg
country: Germany
facility: Research Site
city: Neuhaus am Rennweg
country: Germany
facility: Research Site
city: Neumarkt
country: Germany
facility: Research Site
city: Neumunster
country: Germany
facility: Research Site
city: Neuruppin
country: Germany
facility: Research Site
city: Neustadt an der Weinstrasse
country: Germany
facility: Research Site
city: Neustadt
country: Germany
facility: Research Site
city: Nienburg
country: Germany
facility: Research Site
city: Nordhausen
country: Germany
facility: Research Site
city: Nordhorn
country: Germany
facility: Research Site
city: Numbrecht
country: Germany
facility: Research Site
city: Nurnberg
country: Germany
facility: Research Site
city: Nurtingen
country: Germany
facility: Research Site
city: Oberhausen
country: Germany
facility: Research Site
city: Oberstdorf
country: Germany
facility: Research Site
city: Ochsenfurt
country: Germany
facility: Research Site
city: Offenbach
country: Germany
facility: Research Site
city: Offenburg
country: Germany
facility: Research Site
city: Oranienburg
country: Germany
facility: Research Site
city: Osnabruck
country: Germany
facility: Research Site
city: Paderborn
country: Germany
facility: Research Site
city: Parchim
country: Germany
facility: Research Site
city: Passau
country: Germany
facility: Research Site
city: Peine
country: Germany
facility: Research Site
city: Penzberg
country: Germany
facility: Research Site
city: Pfinztal
country: Germany
facility: Research Site
city: Pforzheim
country: Germany
facility: Research Site
city: Pfullingen
country: Germany
facility: Research Site
city: Pinneberg
country: Germany
facility: Research Site
city: Pirmasens
country: Germany
facility: Research Site
city: Plauen-Kauschwitz
country: Germany
facility: Research Site
city: Pocking
country: Germany
facility: Research Site
city: Potsdam
country: Germany
facility: Research Site
city: Quickborn
country: Germany
facility: Research Site
city: Rahden
country: Germany
facility: Research Site
city: Rangsdorf
country: Germany
facility: Research Site
city: Ravensburg
country: Germany
facility: Research Site
city: Recklinghausen
country: Germany
facility: Research Site
city: Regensburg
country: Germany
facility: Research Site
city: Reinbek
country: Germany
facility: Research Site
city: Remchingen
country: Germany
facility: Research Site
city: Remscheid
country: Germany
facility: Research Site
city: Rendsburg
country: Germany
facility: Research Site
city: Reutlingen
country: Germany
facility: Research Site
city: Rheine
country: Germany
facility: Research Site
city: Rheinfelden
country: Germany
facility: Research Site
city: Riebnitz-Damgarten
country: Germany
facility: Research Site
city: Riesa
country: Germany
facility: Research Site
city: Rodewisch
country: Germany
facility: Research Site
city: Rodgau
country: Germany
facility: Research Site
city: Rosenheim
country: Germany
facility: Research Site
city: Rosrath
country: Germany
facility: Research Site
city: Rotenburg
country: Germany
facility: Research Site
city: Rottenburg
country: Germany
facility: Research Site
city: Rottweil
country: Germany
facility: Research Site
city: Saarbrucken
country: Germany
facility: Research Site
city: Saarlouis
country: Germany
facility: Research Site
city: Salzgitter
country: Germany
facility: Research Site
city: Salzwedel
country: Germany
facility: Research Site
city: Sandhausen
country: Germany
facility: Research Site
city: Sayda
country: Germany
facility: Research Site
city: Schalksmuhle
country: Germany
facility: Research Site
city: Scheibenberg
country: Germany
facility: Research Site
city: Schkeuditz
country: Germany
facility: Research Site
city: Schleswig
country: Germany
facility: Research Site
city: Schonaich
country: Germany
facility: Research Site
city: Schonebeck
country: Germany
facility: Research Site
city: Schorndorf
country: Germany
facility: Research Site
city: Schwabach
country: Germany
facility: Research Site
city: Schwabisch Hall
country: Germany
facility: Research Site
city: Schwandorf
country: Germany
facility: Research Site
city: Schweinfurt
country: Germany
facility: Research Site
city: Schwerin
country: Germany
facility: Research Site
city: Schwerte
country: Germany
facility: Research Site
city: Schwetzingen
country: Germany
facility: Research Site
city: Sebnitz
country: Germany
facility: Research Site
city: Senden
country: Germany
facility: Research Site
city: Siegen
country: Germany
facility: Research Site
city: Simmern
country: Germany
facility: Research Site
city: Singen (Hohentwiel)
country: Germany
facility: Research Site
city: Sogel
country: Germany
facility: Research Site
city: Solingen
country: Germany
facility: Research Site
city: Sommerda
country: Germany
facility: Research Site
city: Spremberg
country: Germany
facility: Research Site
city: Sprockhovel
country: Germany
facility: Research Site
city: St. Wendel
country: Germany
facility: Research Site
city: Starnberg
country: Germany
facility: Research Site
city: Stendal
country: Germany
facility: Research Site
city: Stockelsdorf
country: Germany
facility: Research Site
city: Stralsund
country: Germany
facility: Research Site
city: Stuhr
country: Germany
facility: Research Site
city: Stuttgart
country: Germany
facility: Research Site
city: Sulzbach-Rosenberg
country: Germany
facility: Research Site
city: Teltow
country: Germany
facility: Research Site
city: Tettnang
country: Germany
facility: Research Site
city: Torgau
country: Germany
facility: Research Site
city: Tornesch
country: Germany
facility: Research Site
city: Tubingen
country: Germany
facility: Research Site
city: Uelzen
country: Germany
facility: Research Site
city: Uetze
country: Germany
facility: Research Site
city: Ulm
country: Germany
facility: Research Site
city: Vechta-Langforden
country: Germany
facility: Research Site
city: Vechta
country: Germany
facility: Research Site
city: Veitshochheim
country: Germany
facility: Research Site
city: Viersen
country: Germany
facility: Research Site
city: Villingen-Schwenningen
country: Germany
facility: Research Site
city: Vilsbiburg
country: Germany
facility: Research Site
city: Vlotho
country: Germany
facility: Research Site
city: Vohringen
country: Germany
facility: Research Site
city: Volklingen
country: Germany
facility: Research Site
city: Waldmunchen
country: Germany
facility: Research Site
city: Walsrode
country: Germany
facility: Research Site
city: Wangen
country: Germany
facility: Research Site
city: Warburg
country: Germany
facility: Research Site
city: Warendorf
country: Germany
facility: Research Site
city: Warin
country: Germany
facility: Research Site
city: Wasserburg
country: Germany
facility: Research Site
city: Weiden in der Oberpfalz
country: Germany
facility: Research Site
city: Weingarten
country: Germany
facility: Research Site
city: Wermelskirchen
country: Germany
facility: Research Site
city: Werneck
country: Germany
facility: Research Site
city: Wertheim
country: Germany
facility: Research Site
city: Wetzlar
country: Germany
facility: Research Site
city: Wiesbaden
country: Germany
facility: Research Site
city: Wilster
country: Germany
facility: Research Site
city: Wismar
country: Germany
facility: Research Site
city: Witten
country: Germany
facility: Research Site
city: Witterda
country: Germany
facility: Research Site
city: Wolfen
country: Germany
facility: Research Site
city: Wolfsburg
country: Germany
facility: Research Site
city: Worms
country: Germany
facility: Research Site
city: Wuppertal
country: Germany
facility: Research Site
city: Wurselen
country: Germany
facility: Research Site
city: Wurzburg
country: Germany
facility: Research Site
city: Zittau
country: Germany
facility: Research Site
city: Zossen
country: Germany
facility: Research Site
city: Zwickau
country: Germany
facility: Research Site
city: Zwiesel
country: Germany
facility: Research Site
city: Zwonitz
country: Germany
facility: Research Site
Study officials:
affiliation: AstraZeneca, Germany
name: H Brasch
role: STUDY_DIRECTOR
References:
citation: Hadji P, Jackisch C, Bolten W, Blettner M, Hindenburg HJ, Klein P, Konig K, Kreienberg R, Rief W, Wallwiener D, Zaun S, Harbeck N. COMPliance and Arthralgia in Clinical Therapy: the COMPACT trial, assessing the incidence of arthralgia, and compliance within the first year of adjuvant anastrozole therapy. Ann Oncol. 2014 Feb;25(2):372-7. doi: 10.1093/annonc/mdt513. Epub 2013 Dec 18.