Clinical trial NCT04928027: Self-Reports of Executive Functions in Persons With Parkinson's Disease and Their Significant Others
Official title: Self-Reports of Executive Functions in Persons With Parkinson's Disease and Their Significant Others
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Parkinsonism or Parkinson's Disease Nos
Lead sponsor: Old Dominion University
Sponsor class: OTHER
First posted: 2021-06-16
Enrollment: 100
Sex: ALL
Minimum age (years): 30
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Parkinson's group: Adults with a Parkinson's disease diagnosis and their significant others.

Healthy elderly: no history of neurologic disease (e.g., stroke, traumatic brain injury)

Both groups:

Age 30-79 years with no history of other neurologic diseases, orthopedic, or arthritic conditions that preclude ability to walk

Some of the earliest cognitive symptoms of Parkinsonism involve executive function deficits (e.g., working memory, cognitive flexibility, planning; Williams-Gray, Foltynie, Lewis, and Barker, 2006). What is less understood, however, is whether a relationship exists between the self-reported EFs in persons with Parkinsonism and their significant others. The need for research to investigate the relationship between EFs in persons with Parkinsonism is evident in the limited body of literature currently available.

Brief summary: The investigators are conducting a study to compare the self-reports of executive functions (that is to say, what role cognitive processes such as working memory and attention) in persons with Parkinson's Disease to the reports of executive functions completed by their significant others.

To conduct this study, the investigators need the participation of persons who are diagnosed with Parkinson's Disease and their significant others.

Detailed description: The purpose of this study is to explore the relationship between the self-reported executive functions (EFs) in persons with Parkinsons disease (PD) and their significant others. Executive functions include basic cognitive processes such as attention, inhibition, working memory, and cognitive flexibility. As this proposed study will test not only cognitive functioning, but specific aspects of it (i.e., EFs) without excluding persons with PD who have identified cognitive impairments, outcomes gathered could provide valuable information to better assist all types of persons with PD. Comparing their self-reported EFs to the EF ratings completedy by their signifiant others can help determine if a disparity exists between self-perceptions and actual observed EF abilties. This study would assess EFs through inhibition responses of participants via computerized versions the Comprehensive Executive Function Inventory-Adult Self-Report and Observer forms.

Eligibility criteria: Inclusion Criteria:

* For persons with PD,confirmed diagnosis of PD) For significant others - relationship with person with PD

Exclusion Criteria:All participants will be screened to ensure they do not have:

* any known cognitive disorders other than those associated with PD
* impairments in vision that would affect their ability to safely participate in the study
* recent history of neuromuscular injury/ damage that could affect their ability to complete the CEFI
* the participant will be excluded if he or she is unable to follow commands well enough to complete the CEFI

Primary outcomes:
measure: Comparison of EF outcomes
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Norfolk
country: United States
facility: Old Dominion University
state: Virginia
Study officials:
References: