Clinical trial NCT02817412: Food Response Training for Binge Eating
Official title: Food Response Training for Binge Eating
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Binge Eating
Keywords: binge eating
obesity
overeating
Lead sponsor: Loma Linda University
Sponsor class: OTHER
Collaborators: name: Oregon Research Institute
First posted: 2016-06-29
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will examine the effectiveness of food response training interventions in reducing binge eating among adults engaged in binge eating.

Detailed description: Binge eating disorder is the most prevalent eating disorder and affects both men and women at comparable rates unlike anorexia nervosa and bulimia nervosa. Given that binge eating and obesity are strongly associated, binge eating treatments should aim to reduce binge eating as well as weight. However, most binge eating interventions do not produce lasting weight loss. Recent research has shown computer-based response inhibition training with high-calorie foods reduces reward region response to and attentional bias for the training foods, decreases training food intake, increases inhibitory control, and produces weight loss in overweight adults. There is evidence that the weight loss effects from such response training persist through 6-month follow-up. Further, binge eating has been associated with increased food-related impulsivity and increased activation in a reward-processing brain region to high-calorie foods. Prior research suggests that food response training may be an effective intervention for binge eating that teaches automatic self-control in response to high-calorie foods which in turn, reduces binge eating and produces weight loss. This study will examine the effectiveness of food response training interventions in reducing binge eating and weight among adults engaged in binge eating.

The goals of this study are to: (1) test the hypothesis that adults who complete the food response trainings will show significantly greater reductions in binge eating frequency and in body mass index (BMI) compared to generic response training from pretest to posttest and at 3-month follow up, (2) to determine whether one of the food response trainings is more effective in binge eating frequency and reducing BMI from pretest to posttest and at 3-month follow up, and (3) test whether a reduction in valuation of the high-calorie versus low-calorie foods (willingness to pay for the pictured foods) and/or behavioral improvement of inhibitory control during the training tasks mediate the effects of the various trainings on reductions in binge frequency and body mass index.

Eligibility criteria: Inclusion Criteria:

* Engages in objective binge episodes as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and meets one of the following frequency and duration criteria: 1) at least two objective binge episodes per month for at least 3 months; or 3) at least six objective binge episodes over a shorter period

Exclusion Criteria:

* Illicit drug use and excessive alcohol use

Primary outcomes:
measure: Binge Eating Frequency
timeFrame: Post-intervention (at 4 months)
measure: Binge Eating Frequency
timeFrame: 3-month follow-up (at 7 months)
Secondary outcomes:
measure: Body Mass Index
timeFrame: Post-intervention (at 4 months)
measure: Body Mass Index
timeFrame: 3-month follow-up (at 7 months)
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Sylvia Herbozo
state: Illinois
Study officials:
affiliation: University of Illinois at Chicago
name: Sylvia Herbozo, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: