Clinical trial NCT00069472: Genetic Registry for Rheumatoid Arthritis
Official title: Genetics of Rheumatoid Arthritis Registry
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rheumatoid Arthritis
Keywords: Genetics
Lead sponsor: Northwell Health
Sponsor class: OTHER
Collaborators: name: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
name: Arthritis Foundation
First posted: 2003-09-29
Enrollment: 1062
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: FAMILY_BASED
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Persons with RA who have two living biological parents. Parents can be affected or unaffected with RA. We call the family units "trios".

Brief summary: Many genes are thought to contribute to rheumatoid arthritis (RA). This study will attempt to identify genes that may contribute to RA.

Detailed description: The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study enrolls people diagnosed with with RA and their families.

This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated at his or her doctor's office or other location convenient for the participant. Participants will have a brief phone interview with a study coordinator and a blood sample will be obtained. Disease evaluation will be done at one visit and will include confirmation of diagnosis, a 28 joint count, joint alignment and mobility score (JAMS) and administration of a health assessment questionnaire.

Eligibility criteria: Inclusion Criteria:

* Adult onset RA
* Diagnosis of RA made between 18 and 60 years old
* Both parents alive and willing to participate
* Parents may have diagnosis of RA (affected) or be unaffected

Exclusion Criteria:

* Inflammatory bowel disease
* Lupus
* Psoriatic arthritis

Primary outcomes:
measure: Genetic Association with risk for rheumatoid arthritis
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Manhasset
country: United States
facility: Feinstein Institute for Medical Research
state: New York
Study officials:
affiliation: North Shore University Hospital
name: Peter K. Gregersen, MD
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF, Kastner DL, Seldin MF, Criswell LA, Plenge RM, Holers VM, Mikuls TR, Sokka T, Moreland LW, Bridges SL Jr, Xie G, Begovich AB, Siminovitch KA. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet. 2009 Jul;41(7):820-3. doi: 10.1038/ng.395. Epub 2009 Jun 7.
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