Clinical trial NCT03631810: Contemporary Clinical Management Of Acute Pulmonary Embolism
Official title: Contemporary Clinical Management Of Acute Pulmonary Embolism. The COPE Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Pulmonary Embolism
Keywords: Acute pulmonary embolism
International guidelines
Lead sponsor: Heart Care Foundation
Sponsor class: OTHER
Collaborators: name: University Of Perugia
First posted: 2018-08-15
Enrollment: 5213
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Acute symptomatic objectively diagnosed pulmonary embolism (first or recurrent).

Brief summary: Acute pulmonary embolism is a potentially life-threatening disease with short-term mortality ranges from less than 1% to more than 30% during the hospital stay. Recent guidelines recommend to tailor diagnosis hospitalization and acute treatment based on the estimated risk for short-term Death.

The assessment of the contemporary clinical management of patients with acute pulmonary embolism across different specialties would be of crucial value.

Detailed description: This is a prospective, non-interventional, multicenter study in patients with acute pulmonary embolism admitted to Cardiology, Emergency and Internal Medicine Departments in Italy.

The aim of the study is to assess contemporary management strategies in patients with acute pulmonary embolism in terms of diagnosis, risk stratification, hospitalization and treatment in Italy and assess

1. their association with in-hospital and 30-day mortality and
2. their adherence to current guidelines of the European Society of Cardiology (ESC).

Eligibility criteria: Inclusion Criteria:

* Patients with acute, symptomatic acute pulmonary embolism
* Age ≥ 18 years
* Informed consent

Exclusion Criteria:

* refusal of informed consent
* participation in controlled trials on the management of patients with acute pulmonary embolism

Primary outcomes:
measure: In-hospital death
timeFrame: 30 days
Secondary outcomes:
measure: All cause Mortality and clinical worsening
timeFrame: 30 days
measure: Pulmonary embolism related mortality for and clinical worsening
timeFrame: 30 days
measure: Adherence to guidelines
timeFrame: 30 days
Other outcomes:
Locations:
city: Agrigento
country: Italy
facility: Ospedale San Giovanni Di Dio - Uo Cardiologia E Utic
state: AG
city: Ancona
country: Italy
facility: Ospedali Riuniti - Sod Ps E Medicina D'Urgenza
state: AN
city: Ancona
country: Italy
facility: Istituto Scientifico Inrca - Uo Cardiologia/Utic/Telecardiologia
state: AN
city: San Benedetto Del Tronto
country: Italy
facility: Ospedale Madonna Del Soccorso - Medicina D'Urgenza
state: AP
city: Avezzano
country: Italy
facility: Ospedale Civile Ss. Filippo E Nicola - Uosd Angiologia
state: AQ
city: Arezzo
country: Italy
facility: Ospedale San Donato - Medicina Interna
state: AR
city: Bibbiena
country: Italy
facility: Ospedale Civile - Medicina Interna
state: AR
city: Cortona
country: Italy
facility: Ospedale Valdichiana Santa Margherita - Uos Cardiologia E Hdu
state: AR
city: Montevarchi
country: Italy
facility: Osp. Valdarno 'S. Maria Della Gruccia' - Medicina Interna
state: AR
city: Asti
country: Italy
facility: Ospedale Cardinal Massaia - Medicina A
state: AT
city: Ariano Irpino
country: Italy
facility: Po Sant'Ottone Frangipane - Medicina Generale
state: AV
city: Avellino
country: Italy
facility: Aorn San Giuseppe Moscati - Medicina Interna
state: AV
city: Bari
country: Italy
facility: Ospedale Di Venere - U.O.C. Di Cardiologia
state: BA
city: Bari
country: Italy
facility: Ospedale San Paolo - Cardiologia-Utic
state: BA
city: Bari
country: Italy
facility: Ospedale Policlinico - U.O. Cardiologia Universitaria
state: BA
city: Bari
country: Italy
facility: Ospedale Policlinico - U.O. Di Cardiologia Ospedaliera
state: BA
city: Bergamo
country: Italy
facility: Asst Papa Giovanni Xxiii - Centro Eas
state: BG
city: Bergamo
country: Italy
facility: Asst Papa Giovanni Xxiii - Divisione Di Medicina Interna
state: BG
city: Osio Sotto
country: Italy
facility: Iob - Policlinico San Marco - U.O. Cardiologia
state: BG
city: Treviglio
country: Italy
facility: Ospedali Treviglio-Caravaggio - Cardiologia
state: BG
city: Bologna
country: Italy
facility: Ospedale Policlinico S. Orsola-Malpighi - Uoc Medicina D'Urgenza E Pronto Soccorso
state: BO
city: Bologna
country: Italy
facility: Ospedale Maggiore - Medicina Interna A
state: BO
city: Imola
country: Italy
facility: Ospedale Nuovo S. Maria Della Scaletta - Medicina D'Urgenza E Pronto Soccorso
state: BO
city: Brindisi
country: Italy
facility: Ospedale Perrino - U.O.C. Di Cardiologia
state: BR
city: Brescia
country: Italy
facility: Istituto Osped. Fondazione Poliambulanza - Unita' Operativa Di Cardiologia
state: BS
city: Gavardo
country: Italy
facility: Ospedale Civile 'La Memoria' - U.O. Di Cardiologia
state: BS
city: Andria
country: Italy
facility: Osp. Andria Canosa - Po Andria - Cardiologia - Utic
state: BT
city: Caserta
country: Italy
facility: Az. Ospedaliera S. Anna E S. Sebastiano - Medicina D'Urgenza
state: CE
city: Castel Volturno
country: Italy
facility: Pineta Grande Hospital - Medicina D'Urgenza
state: CE
city: Lanciano
country: Italy
facility: Ospedale 'Renzetti' - Medicina Interna
state: CH
city: Cuneo
country: Italy
facility: Azienda Ospedaliera Santa Croce E Carle - Divisione Di Medicina Interna
state: CN
city: Savigliano
country: Italy
facility: Ospedale Maggiore Ss. Annunziata - Medicina E Chirurgia D'Urgenza
state: CN
city: San Fermo Della Battaglia
country: Italy
facility: Ospedale S. Anna - U.O.C. Di Cardiologia
state: CO
city: Casalmaggiore
country: Italy
facility: Ospedale Civile Oglio Po - Medicina Generale
state: CR
city: Cremona
country: Italy
facility: Ospedale Di Cremona - Medicina Interna
state: CR
city: Cosenza
country: Italy
facility: Ospedale Annunziata - Uoc Cardiologia
state: CS
city: Catania
country: Italy
facility: P.O. Garibaldi-Nesima - U.O.C. Di Cardiologia
state: CT
city: Catania
country: Italy
facility: P.O. Garibaldi Centro - U.O.C. Cardiologia
state: CT
city: Catania
country: Italy
facility: Policlinico Catania Po G. Rodolico - Cardiologia Utic
state: CT
city: Catania
country: Italy
facility: Azienda Ospedaliera Cannizzaro - Medicina Interna
state: CT
city: Catania
country: Italy
facility: Azienda Ospedaliera Cannizzaro - Uoc Cardiologia Con Utic Ed Emodinamica
state: CT
city: Catania
country: Italy
facility: P.O. Garibaldi Centro - Medicina Interna Area Critica
state: CT
city: Catanzaro
country: Italy
facility: Ospedale Civile Pugliese - Utic-Emodinamica E Card. Interventistica
state: CZ
city: Lamezia Terme
country: Italy
facility: Ospedale Giovanni Paolo Ii - U.O. Cardiologia E Utic
state: CZ
city: Forlì
country: Italy
facility: Ospedale G.B. Morgagni - L. Pierantoni - U.O. Cardiologia
state: FC
city: Forlì
country: Italy
facility: Ospedale G.B. Morgagni - L. Pierantoni - U.O. Medicina D'Urgenza-Pronto Soccorso
state: FC
city: Foggia
country: Italy
facility: Ospedali Riuniti - S.C. Di Cardiologia Univ.-Utic
state: FG
city: San Severo
country: Italy
facility: Presidio Ospedaliero T. Masselli Mascia - S.C. Cardiologia - Utic - Riabil. Card.
state: FG
city: Bagno A Ripoli
country: Italy
facility: Ospedale Santa Maria Annunziata - Dea
state: FI
city: Empoli
country: Italy
facility: Ospedale Civile San Giuseppe - Medicina D'Urgenza
state: FI
city: Empoli
country: Italy
facility: Ospedale Civile San Giuseppe - Medicina Interna Ii
state: FI
city: Figline Valdarno
country: Italy
facility: Presidio Ospedaliero Serristori - Medicina Interna E D'Urgenza
state: FI
city: Firenze
country: Italy
facility: Ospedale Santa Maria Nuova - Medicina A2
state: FI
city: Firenze
country: Italy
facility: Ospedale San Giovanni Di Dio - Medicina Interna
state: FI
city: Fermo
country: Italy
facility: Ospedale Civile Augusto Murri - Medicina Interna
state: FM
city: Fermo
country: Italy
facility: Ospedale Civile Augusto Murri - U.O. Cardiologia
state: FM
city: Frosinone
country: Italy
facility: Ospedale Fabrizio Spaziani - Cardiologia-Utic
state: FR
city: Genova
country: Italy
facility: E.O. Ospedali Galliera - Medicina Interna
state: GE
city: Genova
country: Italy
facility: E.O. Ospedali Galliera - S. C. Cardiologia
state: GE
city: Genova
country: Italy
facility: Ospedale Policlinico San Martino - Medicina D'Urgenza 1
state: GE
city: Genova
country: Italy
facility: Ospedale Policlinico San Martino - Unita' Operativa Cardiologia
state: GE
city: Genova
country: Italy
facility: Ospedale Padre Antero Micone - Sc Cardiologia - Utic
state: GE
city: Grosseto
country: Italy
facility: Ospedale Della Misericordia - Pronto Soccorso
state: GR
city: Massa Marittima
country: Italy
facility: Ospedale S. Andrea - Alta Maremma - Divisione Di Medicina
state: GR
city: Sanremo
country: Italy
facility: Presidio Ospedaliero - U.O. Cardiologia
state: IM
city: Lecco
country: Italy
facility: Ospedale Alessandro Manzoni - S.C. Di Cardiologia
state: LC
city: Casarano
country: Italy
facility: Presidio Ospedaliero F. Ferrari - Cardiologia - Utic
state: LE
city: Gallipoli
country: Italy
facility: Ospedale Civile Sacro Cuore Di Gesu' - Uo Cardiologia Utic
state: LE
city: Cecina
country: Italy
facility: Ospedale Civile Bassa Val Di Cecina - Medicina Generale
state: LI
city: Livorno
country: Italy
facility: Ospedali Riuniti - Medicina Generale
state: LI
city: Livorno
country: Italy
facility: Ospedali Riuniti - Pronto Soccorso E Medicina D'Urgenza
state: LI
city: Piombino
country: Italy
facility: Ospedale Villamarina - Medicina Generale
state: LI
city: Lodi
country: Italy
facility: Presidio Ospedaliero Di Lodi - Medicina Generale
state: LO
city: Lido Di Camaiore
country: Italy
facility: Nuovo Ospedale Versilia - Medicina Generale
state: LU
city: Lido Di Camaiore
country: Italy
facility: Nuovo Ospedale Versilia - Pronto Soccorso
state: LU
city: Monza
country: Italy
facility: Ospedale San Gerardo - U.O. Cardiologia-Utic
state: MB
city: Monza
country: Italy
facility: Policlinico Di Monza - Uo Cardiol. Clinica E Scompenso Cardiaco
state: MB
city: Legnano
country: Italy
facility: Ospedale Civile - Medicina Generale
state: MI
city: Magenta
country: Italy
facility: Ospedale Civile Fornaroli - Medicina Interna
state: MI
city: Milano
country: Italy
facility: Ospedale Maggiore Policlinico - Pronto Soccorso E Medicina D'Urgenza
state: MI
city: Milano
country: Italy
facility: Multimedica Ospedale San Giuseppe - Pneumologia
state: MI
city: Milano
country: Italy
facility: Centro Cardiologico Monzino - Terapia Intensiva Cardiologica (Utic)
state: MI
city: Milano
country: Italy
facility: Ospedale San Luca - Istituto Auxologico - U.O. Cardiologia
state: MI
city: Milano
country: Italy
facility: Ospedale San Carlo Borromeo - Cardiologia-Ucc
state: MI
city: Milano
country: Italy
facility: Ospedale San Carlo Borromeo - Pronto Soccorso E Medicina D'Urgenza
state: MI
city: Milano
country: Italy
facility: Asst Ospedale Metropolitano Niguarda - Cardiologia 1 - Emodinamica
state: MI
city: Milano
country: Italy
facility: Asst Ospedale Metropolitano Niguarda - Medicina D'Urgenza E Pronto Soccorso
state: MI
city: Milano
country: Italy
facility: Asst Ospedale Metropolitano Niguarda - Medicina Interna 1
state: MI
city: Sesto San Giovanni
country: Italy
facility: Irccs Policlinico Multimedica - Uo Di Cardiologia
state: MI
city: Matera
country: Italy
facility: Ospedale Madonna Delle Grazie - Pronto Soccorso Tsi
state: Mount
city: Matera
country: Italy
facility: Ospedale Madonna Delle Grazie - U.O. Cardiologia Utic
state: Mount
city: Modena
country: Italy
facility: Ospedale Policlinico - Pronto Soccorso
state: MO
city: Modena
country: Italy
facility: Ospedale Policlinico - Uo Cardiologia
state: MO
city: Modena
country: Italy
facility: Ospedale Civile Di Baggiovara - Medicina D'Urgenza E Pronto Soccorso
state: MO
city: Pavullo Nel Frignano
country: Italy
facility: Presidio Ospedaliero - Divisione Di Medicina Generale
state: MO
city: Sassuolo
country: Italy
facility: Ospedale Di Sassuolo - Medicina D'Urgenza
state: MO
city: Sassuolo
country: Italy
facility: Ospedale Di Sassuolo - Medicina Interna
state: MO
city: Vignola
country: Italy
facility: Ospedale Civile - Uo Pronto Soccorso
state: MO
city: Nuoro
country: Italy
facility: Ospedale San Francesco - Cardiologia - Utic
state: NU
city: Palermo
country: Italy
facility: Osp. Buccheri La Ferla Fatebenefratelli - Dip. Emergenza, Accettaz. E Dei Servizi
state: PA
city: Palermo
country: Italy
facility: Aor Villa Sofia-Cervello Po Villa Sofia - U.O.C. Cardiologia E Utic - Villa Sofia
state: PA
city: Cittadella
country: Italy
facility: Ospedale Di Cittadella - U.O. Cardiologia
state: PD
city: Pescara
country: Italy
facility: Ospedale Civile Dello Spirito Santo - Uo Geriatria
state: PE
city: Città Di Castello
country: Italy
facility: Presidio Ospedaliero Citta' Di Castello - Medicina Interna
state: PG
city: Città Di Castello
country: Italy
facility: Presidio Ospedaliero Citta' Di Castello - U.O. Di Cardiologia
state: PG
city: Perugia
country: Italy
facility: Azienda Ospedaliera Di Perugia - Medicina Interna Vascolare E D'Urgenza
state: PG
city: Todi
country: Italy
facility: Nuovo Ospedale Media Valle Del Tevere - Divisione Di Medicina Interna
state: PG
city: Pontedera
country: Italy
facility: Ospedale Generale Provinciale Lotti - U.O. Malattie Cardiovascolari
state: PI
city: Pordenone
country: Italy
facility: Ospedale Di Pordenone - Ps E Medicina D'Urgenza
state: PN
city: Pordenone
country: Italy
facility: Ospedale Di Pordenone - S.O.C. Cardiologia
state: PN
city: Pescia
country: Italy
facility: Ospedale Della Val Di Nievole - U. O. Cardiologia - Utic
state: Point
city: Prato
country: Italy
facility: Ospedale Santo Stefano - Pronto Soccorso E Medicina D'Urgenza
state: PO
city: Fidenza
country: Italy
facility: Ospedale Civile - Ps E Medicina D'Urgenza
state: PR
city: Pesaro
country: Italy
facility: Presidio Ospedaliero San Salvatore - Cardiologia E Utic
state: PU
city: Pavia
country: Italy
facility: Fondazione Irccs Policlinico San Matteo - Pronto Soccorso
state: PV
city: Melfi
country: Italy
facility: Ospedale S. Giovanni Di Dio - U.O. Cardiologia E Utic
state: PZ
city: Potenza
country: Italy
facility: Azienda Ospedaliera San Carlo - Ssd Utic
state: PZ
city: Potenza
country: Italy
facility: Azienda Ospedaliera San Carlo - Uoc Ps Accettazione Medicina D'Urgenza
state: PZ
city: Faenza
country: Italy
facility: Ospedale Per Gli Infermi - Pronto Soccorso
state: RA
city: Ravenna
country: Italy
facility: Ospedale Civile Santa Maria Delle Croci - Pronto Soccorso E Medicina D'Urgenza
state: RA
city: Reggio Calabria
country: Italy
facility: Ao Bianchi Melacrino Morelli- Po Riuniti - Divisione Di Cardiologia
state: RC
city: Reggio Emilia
country: Italy
facility: Arcispedale Santa Maria Nuova - Medicina Cardiovascolare
state: RE
city: Reggio Emilia
country: Italy
facility: Arcispedale Santa Maria Nuova - Medicina D'Urgenza E Pronto Soccorso
state: RE
city: Scandiano
country: Italy
facility: Ospedale Magati - Divisione Di Medicina-Area Internistica
state: RE
city: Vittoria
country: Italy
facility: Ospedale Riccardo Guzzardi - U.O.C. Di Cardiologia-Utic
state: RG
city: Roma
country: Italy
facility: P.O. San Filippo Neri - Asl Roma 1 - Uoc Cardiologia E Utic
state: RM
city: Roma
country: Italy
facility: Ospedale San Camillo - Cardiologia 2 (Ex Cardio 3)
state: RM
city: Roma
country: Italy
facility: Ospedale San Camillo - Medicina D'Urgenza E Cure Differenziate
state: RM
city: Roma
country: Italy
facility: Ospedale Sandro Pertini - Medicina D'Urgenza
state: RM
city: Roma
country: Italy
facility: Policlinico Umberto Primo - Cardiologia B - Cardiologia E Angiologia
state: RM
city: Roma
country: Italy
facility: Policlinico Casilino - U.O. Cardiologia
state: RM
city: Roma
country: Italy
facility: Ao San Giovanni Addolorata - Uoc Ps-Breve Osservazione
state: RM
city: Roma
country: Italy
facility: Ospedale Fatebenefratelli - Medicina Interna
state: RM
city: Roma
country: Italy
facility: Ospedale Sant'Andrea Di Roma - U.O.C. Cardiologia
state: RM
city: Roma
country: Italy
facility: Ospedale Santo Spirito - U.O.C. Di Cardiologia
state: RM
city: Rimini
country: Italy
facility: Ospedale Infermi - U.O. Cardiologia
state: RN
city: Rovigo
country: Italy
facility: Ospedale Santa Maria Della Misericordia - U.O.C. Cardiologia
state: RO
city: Rovigo
country: Italy
facility: Ospedale Santa Maria Della Misericordia - Uoc Medicina Interna - Angiologia
state: RO
city: Poggibonsi
country: Italy
facility: Ospedale Dell'Alta Val D'Elsa - Uosd Cardiologia-Utic
state: SI
city: Siena
country: Italy
facility: Aou Senese Ospedale S. Maria Alle Scotte - Uoc Medicina Interna 2
state: SI
city: La Spezia
country: Italy
facility: Ospedale S. Andrea - Medicina Interna
state: SP
city: Augusta
country: Italy
facility: Ospedale E. Muscatello - U.O. Di Cardiologia - Utic
state: SR
city: Siracusa
country: Italy
facility: Ospedale Umberto I - Div. Di Medicina - Centro Ipertensione
state: SR
city: Sassari
country: Italy
facility: Ospedale Ss. Annunziata - Pronto Soccorso E Medicina D'Urgenza
state: SS
city: Savona
country: Italy
facility: Ospedale San Paolo - Medicina Interna E Cure Intermedie
state: SV
city: Manduria
country: Italy
facility: Ospedale Civile M. Giannuzzi - Cardiologia E Utic
state: TA
city: Teramo
country: Italy
facility: Ospedale Civile G. Mazzini - Uoc Pronto Soccorso
state: TE
city: Rovereto
country: Italy
facility: Ospedale Santa Maria Del Carmine - Medicina Interna
state: TN
city: Trento
country: Italy
facility: Ospedale Santa Chiara - Medicina Interna I
state: TN
city: Alba
country: Italy
facility: Ospedale Civile San Lazzaro - Medicina Generale
state: TO
city: Chieri
country: Italy
facility: Ospedale Maggiore - Sc Medicina Interna
state: TO
city: Pinerolo
country: Italy
facility: Ospedale Civile E. Agnelli - Medicina-Chirurgia Accettazione-Urgenza
state: TO
city: Rivoli
country: Italy
facility: Ospedale Degli Infermi - Medicina Generale
state: TO
city: Torino
country: Italy
facility: Ospedale Maria Vittoria - U.O. Cardiologia
state: TO
city: Torino
country: Italy
facility: Ospedale Humanitas Gradenigo - Medicina E Chirurgia D'Urgenza
state: TO
city: Erice
country: Italy
facility: Ospedale Civile Sant'Antonio Abate - U.O.C. Di Cardiologia E Utic
state: TP
city: Trieste
country: Italy
facility: Ospedali Riuniti - Osp. Cattinara - Medicina D'Urgenza E Ps
state: TS
city: Trieste
country: Italy
facility: Ospedali Riuniti - Osp. Cattinara - S.O.C. Cardiologia
state: TS
city: Castelfranco Veneto
country: Italy
facility: Stabilimento Ospedaliero Di Castelfranco - Uoc Angiologia
state: TV
city: Montebelluna
country: Italy
facility: Ospedale San Valentino - Divisione Di Medicina Interna
state: TV
city: Treviso
country: Italy
facility: Ospedale Ca' Foncello - Pronto Soccorso Medicina D'Urgenza
state: TV
city: Udine
country: Italy
facility: Pou Santa Maria Della Misericordia - Pronto Soccorso Medicina D'Urgenza
state: UD
city: Luino
country: Italy
facility: Ospedale Di Luino - Medicina Generale
state: VA
city: Saronno
country: Italy
facility: Presidio Ospedaliero Di Saronno - U.O.C. Di Cardiologia
state: VA
city: Varese
country: Italy
facility: Ospedale Di Circolo E Fondazione Macchi - Geriatria
state: VA
city: Varese
country: Italy
facility: Ospedale Di Circolo E Fondazione Macchi - Medicina Generale I
state: VA
city: Vercelli
country: Italy
facility: Ospedale Sant'Andrea - Medicina Interna
state: VC
city: Arzignano
country: Italy
facility: Ospedale Civile - Medicina Interna
state: VI
city: Arzignano
country: Italy
facility: Ospedale Civile - U.O.C. Cardiologia
state: VI
city: Bassano Del Grappa
country: Italy
facility: Ospedale San Bassiano - Sc Di Medicina Interna
state: VI
city: Noventa Vicentina
country: Italy
facility: Ospedale Civile - Medicina Generale 2
state: VI
city: Vicenza
country: Italy
facility: Ospedale Civile San Bortolo - U.O.C. Cardiologia
state: VI
city: San Bonifacio
country: Italy
facility: Ospedale G. Fracastoro - U.O.C. Di Cardiologia
state: VR
city: Verona
country: Italy
facility: Aoui Di Verona - Medicina Gen. Malattie Aterotrombotiche
state: VR
city: Viterbo
country: Italy
facility: Ospedale Belcolle - Medicina Generale
state: VT
city: Vibo Valentia
country: Italy
facility: Ospedale Civile G. Jazzolino - Medicina D'Urgenza
state: VV
city: Napoli
country: Italy
facility: Ospedale Buon Consiglio Fatebenefratelli - Struttura Complessa Di Medicina
city: Napoli
country: Italy
facility: Aorn Cardarelli - Medicina D'Urgenza
city: Napoli
country: Italy
facility: Aou Federico Ii - Uoc Cardiologia E Utic
city: Novara
country: Italy
facility: Aou Maggiore Della Carita' - Cardiologia Ii
city: Pescia
country: Italy
facility: Ospedale Della Val Di Nievole - Medicina Generale
city: Pozzuoli
country: Italy
facility: Ospedale Santa Maria Delle Grazie - U.O. Cardiologia - Utic
Study officials:
References:
citation: Becattini C, Agnelli G, Maggioni AP, Dentali F, Fabbri A, Enea I, Pomero F, Ruggieri MP, Di Lenarda A, Gulizia M. Contemporary clinical management of acute pulmonary embolism: the COPE study. Intern Emerg Med. 2022 Apr;17(3):715-723. doi: 10.1007/s11739-021-02855-0. Epub 2022 Jan 4.