Clinical trial NCT06872892: The AIRTIVITY® Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
Official title: A Phase III, Randomised, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of BI 1291583 2.5 mg Administered Once Daily for up to 76 Weeks in Patients With Bronchiectasis (The AIRTIVITY® Study)
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE3
Conditions: Bronchiectasis
Lead sponsor: Boehringer Ingelheim
Sponsor class: INDUSTRY
First posted: 2025-03-12
Enrollment: 1680
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is open to adults with bronchiectasis. People can participate in this study if they produce sputum and have had flare-ups (also called exacerbations).

The purpose of this study is to find out whether a medicine called BI 1291583 helps people with bronchiectasis. Participants are put into 2 groups randomly, which means by chance. One group takes BI 1291583 tablets and the other group takes placebo tablets. A placebo tablet looks like the BI 1291583 tablet but does not contain any medicine. Participants take 1 tablet once a day for up to 1 year and 6 months.

Participants are in the study for up to 1 year and 8 months. During this time, participants visit the study site up to 10 times and get about 13 phone calls from the site staff. Participants complete a daily diary on a smartphone about their bronchiectasis symptoms and study doctors regularly check for any changes. The study doctors document when participants experience flare-ups. The number of flare-ups is compared between the participants who receive BI 1291583 and those who receive the placebo. The study doctors also regularly check participants' health and take note of any unwanted effects.


Eligibility criteria: Inclusion criteria:

* Male or female participants. Woman of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per International Council of Harmonisation (ICH) M3 (R2) that result in a low failure rate of less than 1 % per year when used consistently and correctly, as well as one barrier method. A list of contraception methods meeting these criteria is provided in the participant information.
* Signed and dated written informed consent prior to admission to the study, in accordance with Good Clinical Practice (GCP) and local legislation.
* Age of participants when signing the informed consent ≥18 (at least the legal age of consent in countries where it is greater than 18 years) years.
* Clinical history consistent with bronchiectasis (e.g. cough, chronic sputum production, recurrent respiratory infections) and investigator confirmed diagnosis of bronchiectasis by Computed Tomography (CT) scan. Participants whose past CT scan image records are not available will undergo a chest CT scan during Screening. Historical scans must not be older than five years.
* Participants should be able to produce sputum for screening.
* History of documented pulmonary exacerbations requiring antibiotic treatment. In the 12 months before Visit 1, participants must have had either:

  * at least 2 exacerbations, or
  * at least 1 exacerbation and an St. George's Respiratory Questionnaire (SGRQ) Symptoms score of \>40 at screening Visit 1 For participants on stable oral or inhaled antibiotics as chronic treatment for bronchiectasis and participants on Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapy (CFTR-MT), at least one exacerbation must have occurred since initiation of stable antibiotics or CFTR-MT.

Exclusion criteria:

* Any new or newly diagnosed condition of primary or secondary immunodeficiency within 1 year before randomisation.
* Allergic bronchopulmonary aspergillosis being treated or requiring treatment.
* Tuberculosis or non-tuberculosis mycobacterial infection being treated or requiring treatment
* Any findings in the medical examination and/or laboratory value assessed at Screening Visit 1 or during screening period, that in the opinion of the investigator may put the participant at risk by participating in the trial.
* Any clinically relevant (at the discretion of the investigator) acute respiratory infection or ongoing pulmonary exacerbation at screening visit or during the screening unless recovered in the opinion of the investigator prior to Visit 2.
* Any relevant pulmonary, gastrointestinal, hepatic, renal, cardiovascular, metabolic, immunological, hormonal, or other disorder that, in the opinion of the investigator, may put the participant at risk by participating in the study.
* Major surgery (major according to the investigator's assessment) performed within 6 weeks prior to randomisation or scheduled during trial period.
* Any documented active or suspected malignancy or history of malignancy within 5 years prior to screening, except appropriately treated in situ non-melanoma skin cancers or in situ carcinoma of uterine cervix.
* Evidence or medical history of moderate or severe liver disease (Child-Pugh score B or C hepatic impairment).
* estimated Glomerular Filtration Rate (eGFR) according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula \<30 mL/min at Visit 1.
* Previous treatment with a dipeptidyl peptidase-1 (DPP1) (Cathepsin C (CatC)) inhibitor. (Note: Participants that were randomised and only received placebo in studies with DPP1 (CatC) inhibitor are allowed.) Further exclusion criteria apply.

Primary outcomes:
measure: Annualized rate of pulmonary exacerbations (number of events per person year) up to Week 76
timeFrame: up to 76 weeks
Secondary outcomes:
measure: Absolute change from baseline in post-bronchodilator Forced Expiratory Volume in the first second (FEV1) %pred at Week 52
timeFrame: at baseline, at week 52
measure: Absolute change from baseline in Quality of Life Questionnaire - Bronchiectasis (QOL-B) respiratory symptoms domain score at Week 52
timeFrame: at baseline, at week 52
measure: Time to first pulmonary exacerbation up to Week 76
timeFrame: up to 76 weeks
measure: Absolute change from baseline in post-bronchodilator Forced Vital Capacity (FVC) %pred at Week 52
timeFrame: at baseline, at week 52
measure: Annualized rate of severe pulmonary exacerbations up to Week 76
timeFrame: up to 76 weeks
measure: Time to first severe pulmonary exacerbation up to Week 76
timeFrame: up to 76 weeks
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Anchorage
country: United States
facility: Providence Medical Group Alaska
state: Alaska
city: Phoenix
country: United States
facility: Dignity Health, St. Joseph's Hospital and Medical Center
state: Arizona
city: Newport Beach
country: United States
facility: Huntington Beach Internal Medicine Group
state: California
city: Redding
country: United States
facility: Paradigm Clinical Research - Redding
state: California
city: Sacramento
country: United States
facility: University of California Davis
state: California
city: Ventura
country: United States
facility: Ventura County Medical Center
state: California
city: New Haven
country: United States
facility: Yale University School of Medicine
state: Connecticut
city: Washington
country: United States
facility: Georgetown University
state: District of Columbia
city: Altamonte Springs
country: United States
facility: Central Florida Pulmonary Group
state: Florida
city: Clearwater
country: United States
facility: Saint Francis Sleep, Allergy and Lung Institute, LLC
state: Florida
city: Gainesville
country: United States
facility: Malcom Randall VA Medical Center
state: Florida
city: Jacksonville
country: United States
facility: University of Florida College of Medicine
state: Florida
city: Jacksonville
country: United States
facility: Mayo Clinic - Florida
state: Florida
city: Miami
country: United States
facility: University of Miami
state: Florida
city: Naples
country: United States
facility: Essence MD Research
state: Florida
city: Tampa
country: United States
facility: Meris Clinical Research-Tampa-70333
state: Florida
city: The Villages
country: United States
facility: Premier Medical Associates
state: Florida
city: Weston
country: United States
facility: Cleveland Clinic Florida
state: Florida
city: Atlanta
country: United States
facility: Emory University
state: Georgia
city: Augusta
country: United States
facility: Augusta University
state: Georgia
city: Chicago
country: United States
facility: Northwestern University
state: Illinois
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics
state: Iowa
city: Kansas City
country: United States
facility: University of Kansas Medical Center
state: Kansas
city: Baltimore
country: United States
facility: Johns Hopkins University
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Worcester
country: United States
facility: UMASS Memorial Medical Center
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan Health System
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic, Rochester
state: Minnesota
city: Saint Paul
country: United States
facility: Health Partners Specialty
state: Minnesota
city: Jackson
country: United States
facility: University Of Mississippi Medical Center
state: Mississippi
city: Chesterfield
country: United States
facility: St.Luke's CardioPulmonary Rsrch Center
state: Missouri
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
city: Omaha
country: United States
facility: University of Nebraska Medical Center
state: Nebraska
city: New Brunswick
country: United States
facility: Rutgers Robert Wood Johnson Medical School
state: New Jersey
city: Hawthorne
country: United States
facility: Children's & Women's Physicians of Westchester
state: New York
city: New Hyde Park
country: United States
facility: Northwell Health
state: New York
city: New York
country: United States
facility: NYU Langone Health
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai
state: New York
city: New York
country: United States
facility: Columbia University Medical Center-New York Presbyterian Hospital
state: New York
city: New York
country: United States
facility: NewYork-Presbyterian/Weill Cornell Medical Center
state: New York
city: Chapel Hill
country: United States
facility: The University of North Carolina at Chapel Hill
state: North Carolina
city: Huntersville
country: United States
facility: Advanced Respiratory and Sleep Medicine
state: North Carolina
city: Pinehurst
country: United States
facility: Pinehurst Medical Clinic, Inc. - East
state: North Carolina
city: Cincinnati
country: United States
facility: University of Cincinnati
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals of Cleveland
state: Ohio
city: Bend
country: United States
facility: Summit Health
state: Oregon
city: Portland
country: United States
facility: Oregon Health and Sciences University
state: Oregon
city: DuBois
country: United States
facility: Clinical Research Associates of Central PA
state: Pennsylvania
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
city: Philadelphia
country: United States
facility: Cancer Treatment Centers of America at Eastern Regional Medical Center
state: Pennsylvania
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: Cypress
country: United States
facility: Horizon Clinical Research Group
state: Texas
city: El Paso
country: United States
facility: El Paso Pulmonary Association
state: Texas
city: Galveston
country: United States
facility: University of Texas Medical Branch at Galveston
state: Texas
city: McKinney
country: United States
facility: Metroplex Pulmonary & Sleep Center
state: Texas
city: San Antonio
country: United States
facility: UT Health San Antonio
state: Texas
city: San Antonio
country: United States
facility: Pulmonary and Sleep Institute
state: Texas
city: Tyler
country: United States
facility: University of Texas Health Science Center at Tyler
state: Texas
city: Murray
country: United States
facility: Intermountain Healthcare
state: Utah
city: Falls Church
country: United States
facility: Inova Fairfax Medical Campus
state: Virginia
city: Richmond
country: United States
facility: Virginia Commonwealth University Health Systems
state: Virginia
city: Seattle
country: United States
facility: University of Washington
state: Washington
city: Madison
country: United States
facility: University of Wisconsin
state: Wisconsin
city: Alberdi Sur
country: Argentina
facility: Centro Dr. Lazaro Langer S.R.L
city: Bahia Blanca
country: Argentina
facility: Centro de Enfermedades Cardiovasculares (CEC)
city: Buenos Aires
country: Argentina
facility: Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich
city: Caba
country: Argentina
facility: Hospital Aleman
city: Caba
country: Argentina
facility: Centro de Investigación Clinica Belgrano
city: Caba
country: Argentina
facility: CEDIC - Centro de Investigacion Clinica
city: Caba
country: Argentina
facility: Mautalen- Salud e Investigacion
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: APRILLUS-Asistencia e Investigacion
city: Mar del Plata
country: Argentina
facility: Instituto Ave Pulmo
city: Quilmes
country: Argentina
facility: Centro Respiratorio de Quilmes
city: Rosario
country: Argentina
facility: Instituto de Especialidades de la Salud Rosario
city: Santa Fe
country: Argentina
facility: Ibamedica
city: Parkville
country: Australia
facility: The Royal Children's Hospital
state: Victoria
city: Graz
country: Austria
facility: Medical University of Graz State Hospital - University Hospital Graz
city: Innsbruck
country: Austria
facility: Medical University of Innsbruck
city: Wels
country: Austria
facility: Klinikum Wels - Grieskirchen GmbH
city: Bruxelles
country: Belgium
facility: Brussels - UNIV Saint-Luc
city: Gent
country: Belgium
facility: UNIV UZ Gent
city: Leuven
country: Belgium
facility: UZ Leuven
city: Sint-Niklaas
country: Belgium
facility: Vitaz - Campus Sint-Niklaas
city: Botucatu
country: Brazil
facility: Faculdade de Medicina de Botucatu - UNESP
city: Goiânia
country: Brazil
facility: HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
city: João Pessoa
country: Brazil
facility: Hospital Universitário Lauro Wanderley
city: Porto Alegre
country: Brazil
facility: Irmandade da Santa Casa de Misericórdia de Porto Alegre
city: Sao Bernardo do Campo
country: Brazil
facility: Netspiro Clinica Medica Ltda - Respsono
city: Pernik
country: Bulgaria
facility: MHAT Rahila Angelova AD
city: Plovdiv
country: Bulgaria
facility: Medical Center Unimed
city: Ruse
country: Bulgaria
facility: SHATPPD "Dr. Dimitar Gramatikov"
city: Sofia
country: Bulgaria
facility: Diagnostics And Consultation Center Convex Ltd.
city: Sofia
country: Bulgaria
facility: Medical Center "Pulmovision"
city: Veliko Tarnovo
country: Bulgaria
facility: Medical Center Tara
city: Vidin
country: Bulgaria
facility: Medical Center "Sveti Ivan Rilski"
city: Vratsa
country: Bulgaria
facility: Sbalpfz-Vratsa
city: Calgary
country: Canada
facility: University of Calgary
state: Alberta
city: Vancouver
country: Canada
facility: St. Paul's Hospital (Vancouver)
state: British Columbia
city: Winnipeg
country: Canada
facility: Cardio 1 Medical Clinic
state: Manitoba
city: Halifax
country: Canada
facility: QEII Health Sciences Centre
state: Nova Scotia
city: Burlington
country: Canada
facility: BLC Clinical Research
state: Ontario
city: Montreal
country: Canada
facility: Centre Hospitalier de l'Universite de Montreal (CHUM)
state: Quebec
city: Sherbrooke
country: Canada
facility: Diex Recherche (Sherbrooke)
state: Quebec
city: Trois-Rivieres
country: Canada
facility: Diex Recherche (Trois-Rivieres)
state: Quebec
city: Saskatoon
country: Canada
facility: Royal University Hospital (Saskatoon)
state: Saskatchewan
city: Quebec
country: Canada
facility: IUCPQ (Laval University)
city: Santiago de Chile
country: Chile
facility: Centro de Estudios Clínicos CEC
city: Talca
country: Chile
facility: Centro de Investigación del Maule
city: Beijing
country: China
facility: China-Japan Friendship Hospital
city: Beijing
country: China
facility: Peking University People's Hospital
city: Beijing
country: China
facility: Peking University Third Hospital
city: Beijing
country: China
facility: Peking Union Medical College Hospital
city: Changchun
country: China
facility: The First Hospital of Jilin University
city: Changchun
country: China
facility: The Second Hospital of Jilin University
city: Changsha
country: China
facility: The Second Xiangya Hospital Of Central South University
city: Chengdu
country: China
facility: West China Hospital
city: Chengdu
country: China
facility: People's Hospital of Sichuan Province
city: Guangzhou
country: China
facility: First Affiliated Hospital of Guangzhou Medical University
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
city: Guiyang
country: China
facility: Guizhou People's Hospital
city: Hangzhou
country: China
facility: The First Affiliated Hospital, Zhejiang University
city: Hangzhou
country: China
facility: Hangzhou First People's Hospital
city: Hangzhou
country: China
facility: The Second Affiliated Hospital Zhejiang University School of Medicine
city: Hangzhou
country: China
facility: Zhejiang Hospital
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
city: Hefei
country: China
facility: The First Affiliated Hospital of Anhui Medical University
city: Huzhou
country: China
facility: Huzhou Central Hospital
city: Jiangmen
country: China
facility: Jiangmen Central Hospital
city: Jinan
country: China
facility: The First Affiliated Hospital of Shandong First Medical University
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University
city: Nanchang
country: China
facility: The Second Affiliated Hospital to Nanchang University
city: Nanjing
country: China
facility: Nanjing First Hospital
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital
city: Nantong
country: China
facility: Affiliated Hospital of Nantong University
city: Ningbo
country: China
facility: Ningbo Medical Center Lihuili Hospital
city: Ningbo
country: China
facility: The First Affiliated Hospital of Ningbo University
city: Pingxiang
country: China
facility: Pingxiang People's Hospital
city: Qingdao
country: China
facility: Qingdao Municipal Hospital
city: Quanzhou
country: China
facility: The Second Affiliated Hospital of Fujian Medical University
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
city: Shanghai
country: China
facility: Zhongshan Hospital Affiliated to Fudan University
city: Shanghai
country: China
facility: Huadong Hospital affiliated to Fudan University
city: Shanghai
country: China
facility: Shanghai General Hospital
city: Shanghai
country: China
facility: Shanghai Fifth People's Hospital affiliated to Fudan University
city: Shanghai
country: China
facility: Shanghai Pulmonary Hospital
city: Shanghai
country: China
facility: Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
city: Shenzhen
country: China
facility: Shenzhen People's Hospital
city: Suining
country: China
facility: Suining Central Hospital
city: Suzhou
country: China
facility: The First Affiliated Hospital of Soochow University
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
city: Wenzhou
country: China
facility: Wenzhou People's Hospital
city: Wuhan
country: China
facility: Wuhan Union Hospital
city: Wuxi
country: China
facility: Wuxi People's Hospital
city: Xi'an
country: China
facility: First Affiliated Hospital of Xi'an JiaoTong University
city: Xuzhou
country: China
facility: Affiliated Hospital, Xuzhou Medical college
city: Yangzhou
country: China
facility: Northern Jiangsu People's Hospital
city: Yixing
country: China
facility: Yixing People'S Hospital
city: Zhejiang
country: China
facility: The First Affiliated Hosptial of Wenzhou Medical University
city: Rijeka
country: Croatia
facility: Specialty Hospital Medico
city: Zagreb
country: Croatia
facility: Clinical Hospital Centre Zagreb
city: Jindrichuv Hradec
country: Czechia
facility: Associated pulmonary and anesthesiology outpatient clinic
city: Prague
country: Czechia
facility: University Hospital Motol
city: Prague
country: Czechia
facility: Policlinic Vysocany
city: Aarhus N
country: Denmark
facility: Aarhus University Hospital
city: Hvidovre
country: Denmark
facility: Hvidovre Hospital
city: Odense C
country: Denmark
facility: Odense University Hospital
city: Vejle
country: Denmark
facility: Vejle University Hospital
city: Ålborg
country: Denmark
facility: Aalborg Sygehus Syd
city: Cairo
country: Egypt
facility: Ain Shams University Clinical Research Center (MASRI)
city: Cairo
country: Egypt
facility: Air Force Specialized Hospital
city: Helsinki
country: Finland
facility: Helsinki University Hospital
city: Oulu
country: Finland
facility: Oulun yliopistollinen keskussairaala
city: Tampere
country: Finland
facility: Tampere University Hospital
city: Turku
country: Finland
facility: Turku University Hospital / TYKS
city: Amiens
country: France
facility: HOP Amiens-Picardie Sud
city: Créteil
country: France
facility: HOP Intercommunal
city: Lille
country: France
facility: INS Coeur Poumon
city: Lyon
country: France
facility: HOP Croix-Rousse
city: Montpellier
country: France
facility: HOP Arnaud de Villeneuve
city: Nice
country: France
facility: HOP Pasteur
city: Paris
country: France
facility: HOP Cochin
city: Pessac
country: France
facility: HOP Haut-Lévêque
city: Rennes
country: France
facility: HOP Pontchaillou
city: Saint-Herblain
country: France
facility: HOP Nord Laennec
city: Tououse
country: France
facility: HOP Larrey
city: Ahrensburg
country: Germany
facility: Velocity Clinical Research Germany GmbH-Ahrensburg-69816
city: Bamberg
country: Germany
facility: CIMS Studienzentrum Bamberg GmbH
city: Berlin
country: Germany
facility: Charite Universitätsmedizin Berlin KöR
city: Berlin
country: Germany
facility: Vivantes Netzwerk für Gesundheit GmbH
city: Berlin
country: Germany
facility: Evangelische Lungenklinik Berlin
city: Berlin
country: Germany
facility: Charite Universitätsmedizin Berlin KöR
city: Bochum
country: Germany
facility: Katholisches Klinikum Bochum gGmbH
city: Bonn
country: Germany
facility: Universitätsklinikum Bonn AöR
city: Donaustauf
country: Germany
facility: Caritas-Krankenhaus St. Maria gGmbH
city: Dortmund
country: Germany
facility: Klinikum Dortmund gGmbH
city: Dresden
country: Germany
facility: Technische Universität Dresden
city: Essen
country: Germany
facility: Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH
city: Frankfurt
country: Germany
facility: Universitätsklinikum Frankfurt
city: Frankfurt
country: Germany
facility: IKF Pneumologie GmbH & Co. KG
city: Freiburg
country: Germany
facility: Universitätsklinikum Freiburg
city: Gauting
country: Germany
facility: Asklepios Fachkliniken München-Gauting
city: Halle/Saale
country: Germany
facility: Krankenhaus Martha-Maria Halle-Dölau gGmbH
city: Halle
country: Germany
facility: Martin-Luther-Universität Halle-Wittenberg
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
city: Heidelberg
country: Germany
facility: Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg
city: Immenhausen
country: Germany
facility: Lungenfachklinik Immenhausen
city: Jena
country: Germany
facility: Universitätsklinikum Jena
city: Kiel
country: Germany
facility: Universitätsklinikum Schleswig-Holstein, Campus Kiel
city: Köln
country: Germany
facility: Augustiner Krankenhäuser GmbH
city: Köln
country: Germany
facility: Universitätsklinikum Köln (AöR)
city: Lübeck
country: Germany
facility: Velocity Clinical Research Germany GmbH-Lübeck-69809
city: Mainz
country: Germany
facility: Universitätsmedizin der Johannes Gutenberg-Universität Mainz
city: München
country: Germany
facility: Klinikum der Universität München AÖR
city: Münster
country: Germany
facility: Universitätsklinikum Münster
city: Potsdam
country: Germany
facility: Klinikum Westbrandenburg GmbH
city: Stralstund
country: Germany
facility: Helios Hanseklinikum Stralsund
city: Wiesbaden
country: Germany
facility: BAG Wiesbaden
city: Athens
country: Greece
facility: Athens Naval Hospital
city: Athens
country: Greece
facility: Chest Hospital of Athens "Sotiria"
city: Heraklion, Crete
country: Greece
facility: University General Hospital of Heraklion
city: Patras
country: Greece
facility: Univ. Gen. Hosp. of Patras
city: Thessaloniki
country: Greece
facility: General Hospital of Thessaloniki "G. Papanikolaou"
city: Hong Kong
country: Hong Kong
facility: Prince of Wales Hospital-Hong Kong-20715
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
city: Budapest
country: Hungary
facility: Koranyi National Institute For Pulmonolgy
city: Pecs
country: Hungary
facility: Da Vinci Private Clinic
city: Rohtak
country: India
facility: Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
city: Visakhapatnam
country: India
facility: Government Hospital for Chest and Communicable Diseases (GHCCD)
city: Jerusalem
country: Israel
facility: Hadassah Medical Center, Ein-Karem
city: Petach Tikva
country: Israel
facility: Rabin Medical Center Beilinson
city: Bologna
country: Italy
facility: Policlinico S. Orsola-Malpighi
city: Catania
country: Italy
facility: AOU Policlinico G. Rodolico San Marco
city: Genova
country: Italy
facility: Azienda Ospedaliera San Martino
city: Genova
country: Italy
facility: Istituto G. Gaslini
city: Messina
country: Italy
facility: A.O.U.Policlinico G.Martino
city: Milano
country: Italy
facility: Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico
city: Monza (MB)
country: Italy
facility: Azienda Socio Sanitaria Territoriale Di Monza
city: Napoli
country: Italy
facility: A.O. dei Colli
city: Padova
country: Italy
facility: Azienda Ospedaliera Universitaria di Padova
city: Palermo
country: Italy
facility: Policlinico "Paolo Giaccone"
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico S. Matteo
city: Roma
country: Italy
facility: Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
city: Rozzano (MI)
country: Italy
facility: Istituto Clinico Humanitas
city: Verona
country: Italy
facility: Azienda Ospedaliera Universitaria Integrata Verona
city: Aichi, Nagoya
country: Japan
facility: Nagoya University Hospital
city: Aomori, Hirosaki
country: Japan
facility: Hirosaki University Hospital
city: Chiba, Chiba
country: Japan
facility: Chiba University Hospital
city: Chiba, Kamogawa
country: Japan
facility: Kameda Clinic
city: Fukuoka, Fukuoka
country: Japan
facility: Kyushu University Hospital
city: Fukuoka, Fukuoka
country: Japan
facility: Fukuoka University Hospital
city: Fukuoka, Iizuka
country: Japan
facility: Aso Co.,Ltd Iizuka Hospital
city: Hokkaido, Sapporo
country: Japan
facility: Hokkaido University Hospital
city: Hyogo, Himeji
country: Japan
facility: Terada Clinic, Respiratory Medicine & General practice
city: Ibaraki, Tsukuba
country: Japan
facility: University of Tsukuba Hospital
city: Kagoshima, Kagoshima
country: Japan
facility: Kagoshima University Hospital
city: Kanagawa, Yokohama
country: Japan
facility: Kanagawa Cardiovascular and Respiratory Center
city: Kyoto, Joyo
country: Japan
facility: Minami Kyoto Hospital
city: Kyoto, Kyoto
country: Japan
facility: Kyoto University Hospital
city: Mie, Matsusaka
country: Japan
facility: Matsusaka City Hospital
city: Miyagi, Sendai
country: Japan
facility: Tohoku University Hospital
city: Nagasaki, Nagasaki
country: Japan
facility: Nagasaki University Hospital
city: Niigata, Niigata
country: Japan
facility: Niigata University Medical and Dental Hospital
city: Oita, Yufu
country: Japan
facility: Oita University Hospital
city: Okayama, Kurashiki
country: Japan
facility: Kurashiki Central Hospital
city: Osaka, Sakai
country: Japan
facility: National Hospital Organization Kinki-Chuo Chest Medical Center
city: Osaka, Toyonaka
country: Japan
facility: Osaka Toneyama Medical Center
city: Saga, Saga
country: Japan
facility: Saga University Hospital
city: Saitama, Kumagaya
country: Japan
facility: Saitama Cardiovascular and Respiratory Center
city: Shiga, Otsu
country: Japan
facility: Shiga University of Medical Science Hospital
city: Shimane, Matsue
country: Japan
facility: Matsue Medical Center
city: Shizuoka, Hamamatsu
country: Japan
facility: Hamamatsu University Hospital
city: Shizuoka, Hamamatsu
country: Japan
facility: Tenryu Hospital
city: Tokushima, Tokushima
country: Japan
facility: Tokushima University Hospital
city: Tokyo, Bunkyo-ku
country: Japan
facility: Institute of Science Tokyo Hospital
city: Tokyo, Itabashi-ku
country: Japan
facility: Nihon University Itabashi Hospital
city: Tokyo, Kiyose
country: Japan
facility: Fukujuji Hospital
city: Tokyo, Minato-ku
country: Japan
facility: Toranomon Hospital
city: Tokyo, Shinjuku-ku
country: Japan
facility: Keio University Hospital
city: Tokyo, Shinjuku-ku
country: Japan
facility: Tokyo Women's Medical University Hospital
city: Yamaguchi, Ube
country: Japan
facility: Yamaguchi University Hospital
city: Astana
country: Kazakhstan
facility: Multidisciplinary City Hospital №1 of the Akimat of Astana
city: Anyang
country: Korea, Republic of
facility: Hallym University Sacred Heart Hospital
city: Cheongju-si
country: Korea, Republic of
facility: Chungbuk National University Hospital
city: Daegu
country: Korea, Republic of
facility: Yeongnam University Hospital
city: Dong-gu Ulsan
country: Korea, Republic of
facility: Ulsan University Hospital
city: Incheon
country: Korea, Republic of
facility: The Catholic University of Korea, Incheon St. Mary's Hospital
city: Jeollabuk-do
country: Korea, Republic of
facility: Jeonbuk National University Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
city: Seoul
country: Korea, Republic of
facility: Hanyang University Medical Center
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
city: Seoul
country: Korea, Republic of
facility: Kangdong Sacred Heart Hospital
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St.Mary's Hospital
city: Seoul
country: Korea, Republic of
facility: SMG-SNU Boramae Medical Center
city: Seoul
country: Korea, Republic of
facility: Hallym University Kangnam Sacred Heart Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Eunpyeong St. Mary's Hospital
city: Wonju-si, Gangwon State
country: Korea, Republic of
facility: Yonsei University Wonju Severance Christian Hospital
city: Daugavpils
country: Latvia
facility: Med.Center OLVI Health Center Assotiation,Private Practice
city: Daugavpils
country: Latvia
facility: Daugavpils Regional Hospital LTD Centre Outpatient Clinic
city: Jurmala
country: Latvia
facility: VCA Dubultu Medical center
city: Riga
country: Latvia
facility: Riga 1st Hospital
city: Riga
country: Latvia
facility: LUMPII Doctors practice
city: Riga
country: Latvia
facility: Pauls Stradins Clinical University Hospital
city: Riga
country: Latvia
facility: Riga East University Hospital
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kauno Klinikos
city: Klaipeda
country: Lithuania
facility: Republic Klaipeda Hospital
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital, Santariskiu
city: Alor Setar, Kedah
country: Malaysia
facility: Hospital Sultanah Bahiyah
city: Kajang
country: Malaysia
facility: Hospital Sultan Idris Shah Serdang
city: Kelantan
country: Malaysia
facility: Hospital Raja Perempuan Zainab II, Kota Bharu
city: Kuala Lumpur
country: Malaysia
facility: University of Malaya Medical Centre
city: Kuching
country: Malaysia
facility: Sarawak General Hospital
city: WP Kuala Lumpur
country: Malaysia
facility: Institut Perubatan Respiratori
city: Chihuahua
country: Mexico
facility: Centro de Investigacion Integral MEDIVEST S.C
city: Mexico City
country: Mexico
facility: Soluciones terapeuticas medico quirurgicas S de RL de CV
city: Monterrey
country: Mexico
facility: Hospital Universitario Dr Jose Eleuterio Gonzalez
city: Nuevo León
country: Mexico
facility: Hospital Universitario Dr Jose Eleuterio Gonzalez
city: Tlalnepantla
country: Mexico
facility: Clinical Research Institute S.C.
city: Alkmaar
country: Netherlands
facility: Noordwest Ziekenhuisgroep
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC Locatie VUMC
city: Den Haag
country: Netherlands
facility: Haga Ziekenhuis
city: Nijmegen
country: Netherlands
facility: Radboud Universitair Medisch Centrum
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum-ROTTERDAM-50697
city: Utrecht
country: Netherlands
facility: UMC Utrecht
city: Zutphen
country: Netherlands
facility: Gelre Ziekenhuis Zutphen
city: Iloilo City
country: Philippines
facility: Iloilo Doctors Hospital
city: Iloilo
country: Philippines
facility: West Visayas State University Medical Center
city: Mandaluyong City
country: Philippines
facility: Health Cube Medical Clinics
city: Quezon City
country: Philippines
facility: Quirino Memorial Medical Center
city: Taft, Manila
country: Philippines
facility: Philippine General Hospital
city: Bialystok
country: Poland
facility: Respiratory Medicine Centre, private prac., Bialystok
city: Chorzow
country: Poland
facility: M2M Med Sp. z o.o. sp. j.
city: Piaseczno
country: Poland
facility: Screenmed Sp. z o.o.
city: Rzeszow
country: Poland
facility: EMED, Center of Medical Services,Private Prac,Rzeszow
city: Warszawa
country: Poland
facility: Altamed Specjalistyczna Praktyka Lekarska Pawel Sliwinski
city: Wolomin
country: Poland
facility: Medical Center K2J2
city: Aveiro
country: Portugal
facility: ULS da Região de Aveiro
city: Braga
country: Portugal
facility: ULS Braga
city: Coimbra
country: Portugal
facility: ULS de Coimbra, E.P.E.
city: Guimarães
country: Portugal
facility: ULS do Alto Ave
city: Leiria
country: Portugal
facility: ULS da Região de Leiria, E.P.E.
city: Lisboa
country: Portugal
facility: ULS de Santa Maria, E.P.E
city: Porto
country: Portugal
facility: ULS de São João
city: Vila Nova de Gaia
country: Portugal
facility: ULS de Gaia/Espinho, EPE
city: Caguas
country: Puerto Rico
facility: San Juan Bautista School of Medicine
city: San Juan
country: Puerto Rico
facility: VA Caribbean Healthcare System
city: San Juan
country: Puerto Rico
facility: Office of Ricardo Fernandez-Gonzalez, MD
city: Bucharest
country: Romania
facility: Marius Nasta Institute of Pneumophthisiology
city: Cluj-Napoca
country: Romania
facility: SC Medlife S.A
city: Cluj-Napoca
country: Romania
facility: Clinical Hospital of Pneumophysiology Leon Daniello
city: Timisoara
country: Romania
facility: Clinical Hospital Of Infectious Diseases And Pneumophysiology Dr.Victor Babes Timisoara
city: Belgrade
country: Serbia
facility: University Clinical Center of Serbia
city: Kragujevac
country: Serbia
facility: University Clinical Center of Kragujevac
city: Nis
country: Serbia
facility: University Clinical Center Nis
city: Sremska Kamenica
country: Serbia
facility: Institute for Pulmonary Diseases of Vojvodina
city: Uzice
country: Serbia
facility: Health Center Uzice
city: Singapore
country: Singapore
facility: National University Hospital-Singapore-42005
city: Singapore
country: Singapore
facility: Singapore General Hospital
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital
city: Singapore
country: Singapore
facility: Changi General Hospital
city: Kosice
country: Slovakia
facility: Zeleznicna Hospital Kosice
city: Martin
country: Slovakia
facility: Univ. Hospital Martin
city: Spišská Nová Ves
country: Slovakia
facility: Plucna ambulancia Hrebenar s.r.o.
city: Cape Town
country: South Africa
facility: Dr Ismail Abdullah
city: Mount Edgecombe
country: South Africa
facility: Enhancing Care Foundation NPC
city: A Coruña
country: Spain
facility: Hospital A Coruña
city: Badalona
country: Spain
facility: Hospital Germans Trias i Pujol
city: Barcelona
country: Spain
facility: Hospital Vall d'Hebron
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
city: Cádiz
country: Spain
facility: Hospital Universitario Puerto Real
city: El Palmar
country: Spain
facility: Hospital Universitario Virgen de la Arrixaca
city: Girona
country: Spain
facility: Hospital Universitari de Girona Doctor Josep Trueta
city: Huelva
country: Spain
facility: Hospital Juan Ramón Jimenez
city: Huelva
country: Spain
facility: Hospital Infanta Elena
city: Jerez de la Frontera
country: Spain
facility: Hospital Jerez de la Frontera
city: L'Hospitalet de Llobregat
country: Spain
facility: Hospital de Bellvitge
city: Madrid
country: Spain
facility: Hospital La Paz
city: Mérida
country: Spain
facility: Hospital de Mérida
city: Oviedo
country: Spain
facility: Hospital Central de Asturias
city: Palma de Mallorca
country: Spain
facility: Hospital Son Espases
city: Pamplona
country: Spain
facility: Complejo Hospitalario de Navarra
city: Pozuelo de Alarcón
country: Spain
facility: Hospital Quirónsalud Madrid
city: Santander
country: Spain
facility: Hospital Universitario Marqués de Valdecilla
city: Santiago de Compostela
country: Spain
facility: Complexo Hospitalario Universitario De Santiago
city: Sevilla
country: Spain
facility: Hospital Virgen Macarena
city: Sevilla
country: Spain
facility: Hospital Virgen del Rocío
city: Sevilla
country: Spain
facility: Hospital Nuestra Señora de Valme
city: Valencia
country: Spain
facility: Hospital Politècnic La Fe
city: Stockholm
country: Sweden
facility: Karolinska University Hospital
city: Uppsala
country: Sweden
facility: CTC Clinical Trial Consultants AB
city: Örebro Län
country: Sweden
facility: Universitetssjukhuset, Örebro
city: Basel
country: Switzerland
facility: University Hospital Basel
city: Lausanne
country: Switzerland
facility: University Hospital of Lausanne
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: TaoYuan
country: Taiwan
facility: Chang Gung Memorial Hospital(Linkou)
city: Yunlin County
country: Taiwan
facility: National Taiwan University Hospital Yun-Lin Branch
city: Bangkok
country: Thailand
facility: Ramathibodi Hospital
city: Bangkok
country: Thailand
facility: Siriraj Hospital
city: Khon Kaen
country: Thailand
facility: Srinagarind Hospital
city: Patumwan
country: Thailand
facility: King Chulalongkorn Memorial Hospital
city: Songkla
country: Thailand
facility: Songklanagarind Hospital
city: Istanbul
country: Turkey
facility: Istanbul University Medical Faculty Capa Hospital
city: Istanbul
country: Turkey
facility: Marmara University Pendik Training and Research Hospital
city: Hanoi
country: Vietnam
facility: National Lung Hospital
city: Ho Chi Minh City
country: Vietnam
facility: Cho Ray Hospital
city: Ho Chi Minh City
country: Vietnam
facility: Nhan Dan Gia Dinh Hospital
city: Ho Chi Minh City
country: Vietnam
facility: University Medical Center HCMC
Study officials:
References: