Clinical trial NCT06903182: Preoperative TAP Block Versus Postoperative TAP Block in Patients Undergoing Laparoscopic Cholecystectomy: a Randomized Controlled Trial
Official title: Preoperative TAP Block Versus Postoperative TAP Block in Patients Undergoing Laparoscopic Cholecystectomy: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: TAP Block
Keywords: TAP block
laparoscopic cholecistectomy
Lead sponsor: University of Padova
Sponsor class: OTHER
First posted: 2025-03-30
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to learn if the regional anesthesia technique "TAP block" provide more analgesia when performed before or after the surgery. The main questions it aims to answer are:

Does preoperative TAP block provide greater analgesia than postoperative TAP block? Patients receiving preoperative TAP block will have less pain and take less painkillers than patients receiving postoperative TAP block?

Participants will:

Receive preoperative or postoperative TAP block They will be asked about their pain levels during the hospital stay.

Detailed description: The TAP block is a safe, easy-to-perform, and effective technique for managing postoperative pain. It reduces opioid consumption and increases patient satisfaction. Despite recent studies indicating that postoperative TAP block might be more effective than preoperative TAP block in reducing opioid use within 24 hours, the optimal timing of its administration (before or after surgery) remains unclear.

In this study we will compare preoperative to postoperative TAP block in patients undergoing laparoscopic cholecistectomy.

The primary aim of this study is to determine the difference in postoperative pain control between preoperative and postoperative TAP block administration in patients undergoing laparoscopic cholecystectomy.

The primary objective will be to evaluate the difference in postoperative pain at rest, 24 hours after surgery, between patients receiving preoperative versus postoperative TAP block. Pain will be assessed using the Numeric Rating Scale (NRS) from 0 to 10.

Secondary objectives will be intraoperative and postoperative opioids, postoperative nausea and vomiting, pain at resnt and on movement at 0,6,12,24 hours.

Eligibility criteria: Inclusion Criteria

* ASA I-II patients
* Age \>18 years
* Informed consent

Exclusion Criteria

* History of chronic pain
* Beta-blocker therapy
* Allergy to the drugs used in the study

Primary outcomes:
measure: Patient reported pain on movement at 24 hours after the surgery
timeFrame: At the 24th hour after the end of the surgery.
Secondary outcomes:
measure: Patient reported pain on movement (cough) at the end of the surgery
timeFrame: At the end of the surgery.
measure: Patient reported pain on rest at the end of the surgery
timeFrame: At the end of the surgery.
measure: Patient reported pain on rest at 6 hours after the surgery
timeFrame: At the 6th hour after the end of the surgery.
measure: Patient reported pain on movement at 6 hours after the surgery
timeFrame: At the 6th hour after the end of the surgery.
measure: Patient reported pain on rest at 12 hours after the surgery
timeFrame: At the 12th hour after the end of the surgery.
measure: Patient reported pain on movement at 12 hours after the surgery
timeFrame: At the 12th hour after the end of the surgery.
measure: Patient reported pain on rest at 24 hours after the surgery
timeFrame: At the 24th hour after the end of the surgery.
measure: Difference in intraoperative opioids
timeFrame: From the enrollment to the extubation
measure: Difference in postoperative opioids
timeFrame: From the extubation to the 24th postoperative hours
measure: Number of participants experiencing postoperative nausea and vomiting
timeFrame: From extubation to the 24th postoperative hour
Other outcomes:
Locations:
city: Padua
country: Italy
facility: University Hospital of Padua
Study officials:
References: