Clinical trial NCT00325520: A Neurocognitive Model of Anorexia Nervosa
Official title: A Neurocognitive Model of Anorexia Nervosa
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anorexia Nervosa
Lead sponsor: New York State Psychiatric Institute
Sponsor class: OTHER
Collaborators: name: Klarman Family Foundation
name: National Institute of Mental Health (NIMH)
First posted: 2006-05-15
Enrollment: 152
Sex: ALL
Minimum age (years): 16
Maximum age (years): 45
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Anorexia Nervosa or Healthy Volunteers

Brief summary: The purpose of this study is to investigate thought processes and neural mechanisms that may contribute to the development of habitual behaviors. The investigators hypothesize that patients with AN will perform differently than people without eating disorders on a series of neuropsychological tasks and will show different neural activation patterns in functional neuroimaging scans.

Detailed description: Patients with Anorexia Nervosa (AN) have extreme difficulty changing their eating behavior, even when they express desire for change. These behaviors seem to override all other potential responses, and can appear perseverative, or habitual. The purpose of this study is to investigate thought processes and neural mechanisms that may contribute to the development of habitual behaviors. The investigators hypothesize that patients with AN will perform differently than people without eating disorders on a series of neuropsychological tasks and will show different neural activation patterns in functional neuroimaging scans.

Eligibility criteria: Inclusion:

* DSM-IV-TR™ diagnosis of anorexia nervosa (restricting or binge-purge subtype), current or prior;
* Age 16-45;
* Inpatient on GCRU
* Medically stable.

Exclusion:

* Any other current major Axis I disorder (including current bulimia nervosa), except major depression;
* History of concussion, seizure disorder, or other neurological illness;
* History of learning disability;
* Acute Suicidality

Healthy comparison group:

Inclusion:

* No current or past psychiatric illness;
* Age 16-45
* No history of binge eating or vomiting;
* Normal weight (80%-120% ideal body weight)

Exclusion:

* Significant medical or neurologic illness(concussion, seizure disorder, learning disability, other neurological illness)
* Current psychotropic medication or medications known to impact cognition

Additional Exclusion Criteria for fMRI:

* Significant Claustrophobia
* Pregnancy
* Indwelling metallic object, non-removable metal jewelry, medicinal patch or recent metallic ink tattoo
* For patients, current psychotropic medications (antidepressants for 2 week (prozac and antipsychotics for 4 weeks)
* For patients, any other current Axis I diagnosis

Primary outcomes:
measure: Neuropsychological functioning
timeFrame: pre- and post-treatment
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: New York State Psychiatric Institute
name: Joanna Steinglass, MD
role: PRINCIPAL_INVESTIGATOR
References: