Clinical trial NCT04170114: Comparison of the Efficacy of Comprehensive Respiratory Physiotherapy in Children With Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis
Official title: Comparison of the Efficacy of Comprehensive Respiratory Physiotherapy in Children With Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cystic Fibrosis
Bronchiectasis
Keywords: Cystic Fibrosis
Bronchiectasis
Respiratory Physiotherapy
Pulmonary Function
Exercise Capacity
Six Minute Walk Test
Muscle Strength
Lead sponsor: Bezmialem Vakif University
Sponsor class: OTHER
First posted: 2019-11-20
Enrollment: 60
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The effect of comprehensive respiratory physiotherapy applications on respiratory function, functional capacity and peripheral muscle strength in children with cystic fibrosis and non-cystic fibrosis will be compared.

Detailed description: Bronchiectasis may be a congenital cause such as cystic fibrosis (CF) or non-cystic fibrosis such as primary ciliary dyskinesia, post-infectious conditions, aspiration and immunodeficiency; It is a disease characterized by irreversible dilatation of airways. Symptoms; purulent sputum production, chronic cough, hemoptysis, recurrent fever and pleurisy. Mucociliary clearance disorder secondary to inflammation and involvement of exocrine glands in CF plays a major role in the development of symptoms; In non-cystic fibrosis bronchiectasis (NCFB), the development of similar symptoms may occur regardless of these reasons. However, in the examinations of CF, proximal airways; In NCFB, distal airways have been affected more intensively. As part of pulmonary rehabilitation, comprehensive respiratory physiotherapy (CRP) has an important role in the treatment and management of bronchiectasis. Airway cleaning techniques, approaches to reducing respiratory work, and patient education form the basis of CRP and play an active role in the treatment and management of the disease. In the literature, there are studies in which the effects of CRP are given in both CF and NCFB patients and studies comparing evaluation results in both groups without treatment. However, no study was found to compare the efficacy of CRP in these two groups of diseases. Therefore, in this study, the investigators aimed to investigate the differences between the efficacy of CRP among the groups in children with CF and NCFB.

Eligibility criteria: Inclusion Criteria:

* Being between 6-18 years old
* Clinically diagnosed as cystic fibrosis or non-cystic fibrosis bronchiectasis

Exclusion Criteria:

* Previous history of lung or liver transplantation
* Have had an acute exacerbation in the last month and / or have a history of hospitalization
* Having a diagnosis of orthopedic problems affecting mobility or a history of musculoskelatal surgery

Primary outcomes:
measure: Forced Vital Capacity (FVC)
timeFrame: 8 Weeks
measure: Forced Expiratory Volume in 1 second (FEV1)
timeFrame: 8 Weeks
measure: Peak Expiratory Flow (PEF)
timeFrame: 8 Weeks
measure: Respiratory Muscle Strength - MIP
timeFrame: 8 Weeks
measure: Respiratory Muscle Strength - MEP
timeFrame: 8 Weeks
measure: Six-minute walk test distance
timeFrame: 8 Weeks
measure: M. Quadriceps strength
timeFrame: 8 Weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Bezmialem Vakif Universitesi, Department of Physiotherapy and Rehabilitation
Study officials:
References: