louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05854173: Compare The Effect of Pendulum Exercises With the Kaltenborn Mobilization Among the Patients of Adhesive Capsulitis
Official title: Compare The Effect of Pendulum Exercises With the Kaltenborn Mobilization Among the Patients of Adhesive Capsulitis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Adhesive Capsulitis
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2023-05-11
Enrollment: 38
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: To determine the effect of pendulum exercises with the kaltenborn mobilization among the patients of adhesive capsulitis


Eligibility criteria: Inclusion Criteria:

* Subjects will be of the age group of 40-60 years.
* Can be male or female
* Diagnosed with adhesive capsulitis by orthopedic or physical therapist.
* Pain, stiffness, and limitation of passive shoulder lateral rotation, abduction, and internal rotation of more than 50% compared with the opposite side for at least 3 months

Exclusion Criteria:

* Presence of neurological disorders (e.g., stroke, Parkinson's disease) leading to deficiency of shoulder muscles activity, Severe trauma related to painful stiff shoulder which leads to bony changes of the affected shoulder on radiographs, Previous surgeries and manipulation under anesthesia of the affected shoulder

Primary outcomes:
measure: Shoulder Pain assessed by Visual Analog Scale
timeFrame: 6 Months
measure: disability index
timeFrame: 6 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Superior University CRC
state: Punjab
Study officials:
References:
Clinical trial NCT00213473: Prospective Clinical and Biological Follow-up of Acquired Haemophilia : SACHA Study
Official title: Prospective Clinical and Biological Follow-up of Acquired Haemophilia : SACHA Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acquired Haemophilia
Register
Keywords: acquired haemophilia
Lead sponsor: University Hospital, Rouen
Sponsor class: OTHER
First posted: 2005-09-21
Enrollment: 81
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patient with Acquired haemophilia

Brief summary: the aims of SACHA study was to appreciate prevalence, evolution and follow-up, treatment response of patients with acquired hemophilia with biological and clinical data. Inclusion criteria were factor VIIIc below 30% associated with presence of Facgteur VIII inhibitor (titer \> 1 u Bethesda. Clinical and biologival data were obtained at Day 0 (as soon as possible and at 1, 3, 6 and 12 months.Informations were notified to co-investigators with the help of two french medical society (Internal medicine, french haemostasis and thrombosis society.


Eligibility criteria: Inclusion Criteria:

* Factor VIIIc \< 30% and Factor VIII inhibitor \> 1 u Bethesda

Exclusion Criteria:

* absence and signed consent, haemophilia A

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Rouen
country: France
facility: University Hospital of Rouen
Study officials:
affiliation: University Hospital, Rouen
name: Herve LEVESQUE, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wootla B, Christophe OD, Mahendra A, Dimitrov JD, Repesse Y, Ollivier V, Friboulet A, Borel-Derlon A, Levesque H, Borg JY, Andre S, Bayry J, Calvez T, Kaveri SV, Lacroix-Desmazes S. Proteolytic antibodies activate factor IX in patients with acquired hemophilia. Blood. 2011 Feb 17;117(7):2257-64. doi: 10.1182/blood-2010-07-296103. Epub 2010 Dec 3.
Clinical trial NCT06058273: Bruni® Training in OPHL Patients
Official title: Improvement of the Phonatory Outcome in Patients Undergoing Open Partial Horizontal Laryngectomy (OPHL) and Speech Therapy by Applying the Bruni® Training: a Prospective Cohort Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Substitution Voice
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2023-09-28
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Surgically treated patients with type II OPHL being treated at the Phoniatrics Unit of the Fondazione Policlinico Universitario A. Gemelli-IRCCS, but not satisfied with their voice after the first cycle of therapy with a standard rehabilitation approach, will be recruited. To interested patients, a specific vocal rehabilitation program based on Bruni training will be proposed in order to compare the results obtained using this method with those following the previous treatment.


Eligibility criteria: Inclusion Criteria:

* Age over 18;
* Italian mother tongue;
* ability to produce the replacement voice;
* ability to provide written informed consent

Exclusion Criteria:

* \< 1 year from the end of both surgical and radiotherapy treatment;
* presence of disease recurrence;
* sensory, neurological deficits
* Learning disabilities

Primary outcomes:
measure: Maximum phonation time
timeFrame: 3 months
measure: type of spectrogram
timeFrame: 3 months
measure: foundamental frequency
timeFrame: 3 months
measure: Formantic peaks
timeFrame: 3 months
measure: perceptual evaluation
timeFrame: 3 months
measure: self evaluation of voice
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario A. Gemelli - IRCCS
Study officials:
References:
Clinical trial NCT06951373: Comparison of Multiple Percutaneous Needle Aspiration Versus Incision and Drainage in Small Breast Abscesses: Pain, Cosmesis, and Early Breastfeeding Outcomes
Official title: Comparison of Pain, Cosmesis and Early Restoration of Breast Feeding in Multiple Percutaneous Needle Aspiration Vs Incision and Drainage for Small Breast Abscess Management
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Breast Abscess
Lead sponsor: Quaid-e-Azam Medical College
Sponsor class: OTHER
First posted: 2025-04-30
Enrollment: 110
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to compare the effectiveness of multiple percutaneous needle aspiration (MPNA) versus incision and drainage (ID) for the management of small breast abscesses in breastfeeding women. The trial evaluates three key outcomes: post-procedure pain levels, cosmetic satisfaction, and the timing of breastfeeding restoration. The study is conducted at the Department of Surgery, Bahawal Victoria Hospital Bahawalpur, enrolling 110 lactating women aged 18-45 years with abscesses ≤5 cm in diameter. Participants were treated with either MPNA or ID based on clinical decision and patient preference. Pain levels were assessed using a standardized scale, cosmetic outcomes were evaluated via patient-reported satisfaction, and breastfeeding restoration was monitored at baseline, one week, and one month post-treatment. Findings indicate that MPNA is associated with lower pain scores, better cosmetic satisfaction, and faster resumption of breastfeeding compared to ID, suggesting MPNA as a preferred first-line treatment for small breast abscesses.


Eligibility criteria: Inclusion Criteria:

* Married breastfeeding women Age: 18-45 years Diagnosed with breast abscess (≤5 cm in diameter)

Exclusion Criteria:

* Complicated abscesses Compromised immune system History of prior surgical interventions for breast abscess Unwilling to participate in the study

Primary outcomes:
measure: Pain Score
timeFrame: 1 week post-procedure
measure: Breastfeeding Restoration
timeFrame: 1 month post-procedure
Secondary outcomes:
measure: Cosmetic Satisfaction
timeFrame: 1 month post-procedure
Other outcomes:
Locations:
city: Bahawalpur
country: Pakistan
facility: Bahawal Victoria Hospital
state: Punjab
Study officials:
References:
Clinical trial NCT05594173: Chewing and Oral Processing of Solid Food
Official title: Chewing and Oral Processing of Solid Food in Healthy Swallowing
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dysphagia
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
Collaborators: name: National Institute on Deafness and Other Communication Disorders (NIDCD)
First posted: 2022-10-26
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy adult volunteers with no history of swallowing difficulty

Brief summary: Food texture modification is commonly used as an intervention for people with dysphagia (swallowing impairment). However, the field currently lacks a proper understanding of how this intervention works. The overall goal of this project was to collect measurements of food bolus transit through the oropharynx (i.e., mouth and throat) during chewing, oral processing and swallowing.

Detailed description: Aim: To explore chewing and oral processing behaviors across solid foods of different consistencies (minced and moist, soft \& bite-sized, regular).

Healthy adult participants will be asked to swallow foods representative of the "minced and moist", "soft and bite-sized" and "regular" consistency levels of the International Dysphagia Diet Standardisation Initiative.

We will measure the number of chews taken per bolus and the overall duration of chewing to understand differences across consistencies.

Eligibility criteria: Inclusion Criteria:

* Healthy adults under age 60

Exclusion Criteria:

* prior history of swallowing, motor speech, gastro-esophageal or neurological difficulties, chronic sinusitis or taste disturbance.
* history of surgery to the speech or swallowing apparatus (other than routine tonsillectomy or adenoidectomy)
* Type 1 Diabetes
* Current use of dentures
* cognitive communication difficulties that may hinder comprehension of the study documents or instructions
* known allergies to medical adhesive
* known allergies to ingredients of the food products used in the experiment .

Primary outcomes:
measure: Number of Chewing Cycles Per Bolus
timeFrame: Baseline (single timepoint only)
measure: Total Chewing Duration Per Bolus
timeFrame: Baseline (single timepoint only)
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Toronto Rehabilitation Institute - University Health Network
state: Ontario
Study officials:
affiliation: University Health Network, Toronto
name: Catriona M Steele, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04756973: The Addition of Self-compassion Skills Training to a Behavioral Weight Loss Program Delivered Using Video Conferencing Software
Official title: The Addition of Self-compassion Skills Training to a Behavioral Weight Loss Program Delivered Using Video Conferencing Software
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Weight Loss
Lead sponsor: East Carolina University
Sponsor class: OTHER
First posted: 2021-02-16
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The current study examined the efficacy, feasibility, and acceptability of: 1) adding self-compassion (SC) skills training to a standard behavioral weight loss program (BWLP), and 2) utilizing video conferencing software to deliver small group, weekly, weight loss classes.

Detailed description: Object: The current study examined the efficacy, feasibility, and acceptability of: 1) adding self-compassion (SC) skills training to a standard behavioral weight loss program (BWLP), and 2) utilizing video conferencing software to deliver small group, weekly, weight loss classes.

Method: The BWLP program utilized Webex video conferencing software to deliver a 12-week, interactive, small group, weekly weight loss intervention. Participants were randomized to a standard BWLP or a standard behavioral weight loss program augmented with self-compassion skills training (BWLP+SC).

Eligibility criteria: Inclusion Criteria:

* 18 or older, at a BMI of 27 kg/m2 or greater, and available to attend weekly online groups

Exclusion Criteria:

-

Primary outcomes:
measure: weight loss
timeFrame: 12 weeks
measure: height
timeFrame: baseline
Secondary outcomes:
measure: Self-compassion
timeFrame: 12 weeks
measure: Eating Behaviors
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Greenville
country: United States
facility: East Carolina University
state: North Carolina
Study officials:
affiliation: East Carolina University
name: Robert Carels
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03007173: Umbilical Pilonidal Sinus: a Case Report
Official title: Umbilical Pilonidal Sinus: an Underestimated and Little-known Clinical Entity - Report of Two Cases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Umbilical Cyst
Pilonidal Sinus
Keywords: umbilical pilonidal sinus
Lead sponsor: Medical Park Gaziantep Hospital
Sponsor class: OTHER
First posted: 2017-01-02
Enrollment: 2
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: No limitation for age, gender, ethnicity

Brief summary: Umbilical pilonidal sinus (UPS) is a rare disease of young, hirsute, dark men with deep navels and poor personal hygiene; however, it can be seen in females. UPS could easily be misdiagnosed and mistreated due to its rarity and lack of awareness in physicians. Diagnosis is easy to establish with physical examination and a detailed history. Treatment is generally depending on the severity of the disease, ranging from good personal hygiene to surgical excision of umbilical complex. The treatment of choice for chronic, intermittent cases is surgical removal of the affected portion; paying special attention to cosmetic appearance especially in female patients. In this report, we present two cases of UPS, one in a man and one in a woman with the explanation of its etiopathogenesis and surgical treatment.

Detailed description: Introduction: Umbilical pilonidal sinus (UPS) is a rare disease of young, hirsute, dark men with deep navels and poor personal hygiene. It is being diagnosed and reported more frequently; however, there is still no consensus regarding its best treatment options.

Presentation of cases: In this report, we present two cases of UPS, one in a man and one in a woman who had typical symptoms with pain, swelling and intermittent malodorous discharge from the umbilicus. They had small sinus openings with hair protruding deep in the navel. Because patients had previous history of failed conservative treatments an umbilicus preserving surgery was performed for both cases.

Eligibility criteria: Inclusion Criteria:

* no limitation

Exclusion Criteria:

* patients followed-up less than 2 years

Primary outcomes:
measure: cure rate
timeFrame: within 2 years of follow-up
Secondary outcomes:
measure: healing time
timeFrame: within the postoperative 1 month
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Mehmet Kaplan
Study officials:
affiliation: Medical Park Hospital
name: Mehmet Kaplan, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kaplan M, Ozcan O, Kaplan FC, Yalcin HC, Salman B. Conservative vs Surgical Interventions for Umbilical Pilonidal Sinus: A Multicenter, Double-Blind, Prospective, Randomized Clinical Trial. J Am Coll Surg. 2016 May;222(5):878-89. doi: 10.1016/j.jamcollsurg.2016.01.056. Epub 2016 Feb 23.
Clinical trial NCT00486473: Multihance Versus Magnevist in Breast MRI
Official title: Phase III Multicenter Double-Blind, Randomized, Crossover Study to Compare MultiHance With Magnevist in Contrast-enhanced Magnetic Resonance Imaging (MRI) of the Breast
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Breast Cancer
Lead sponsor: Bracco Diagnostics, Inc
Sponsor class: INDUSTRY
First posted: 2007-06-14
Enrollment: 130
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: To show if one MRI contrast agent is better than another one in the diagnosis of malignant breast lesions compared to histopathology


Eligibility criteria: Inclusion Criteria:

* Provides written informed consent
* Female
* Age 18 years or older
* Suspicious or known breast lesion based on results from mammography or ultrasound
* Planned to undergo histological diagnosis of breast lesion by having a non surgical biopsy or breast surgery within 30 days after the MRI exam

Exclusion Criteria:

* Body weight \> 100 kg
* Pregnant or lactating
* Server or end-stage organ failure
* Moderate to severe renal impairment
* Undergoing radiotherapy or completed radiotherapy in the last 18 months
* Chemotherapy within 6 months of the 1st MRI exam

Primary outcomes:
measure: Sensitivity in diagnosing breast lesions compared to histopathology results
timeFrame: up to 6 months
Secondary outcomes:
measure: Sensitivity, specificity, accuracy, PPV and NPV at region, breast and patient levels
timeFrame: up to 6 months
Other outcomes:
Locations:
city: Rome
country: Italy
Study officials:
affiliation: Bracco Dianostics, Inc.
name: Gianpaolo Pirovano, MD
role: STUDY_DIRECTOR
References:
citation: Martincich L, Faivre-Pierret M, Zechmann CM, Corcione S, van den Bosch HC, Peng WJ, Petrillo A, Siegmann KC, Heverhagen JT, Panizza P, Gehl HB, Diekmann F, Pediconi F, Ma L, Gilbert FJ, Sardanelli F, Belli P, Salvatore M, Kreitner KF, Weiss CM, Zuiani C. Multicenter, double-blind, randomized, intraindividual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine for Breast MR imaging (DETECT Trial). Radiology. 2011 Feb;258(2):396-408. doi: 10.1148/radiol.10100968. Epub 2010 Dec 16.
Clinical trial NCT02136173: Study of Weight Loss Effect of the Sequential Balloons
Official title: Study of Weight Loss Effect of the Sequential Balloons
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Weight Loss
Balloon
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2014-05-12
Enrollment: 300
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The effect of the balloon on weight loss is investigated by multiple studies. However, the effect of the sequential balloons is not studied yet.

Detailed description: We are aiming to study the effect of the sequential balloons in the patients who had weight loss with the first balloon and they need subsequent balloons to have more weight loss after their first balloons are removed after 6 months.

Eligibility criteria: Inclusion Criteria:

* BMI \> 45 and weight \>120 Kg
* Patients refused to have bariatric surgery.

Exclusion Criteria:

* Esophageal or gastric or duodenal lesions.
* Bleeding disorders.
* uncooperative patients.

Primary outcomes:
measure: weight loss
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mansoura University
Study officials:
References:
Clinical trial NCT05640973: TCOM Ring Evaluation
Official title: Clinical Usability of a Novel Non-Adhesive Applicator for the Monitoring of tcPCO2 in Neonates
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Carbon Dioxide Partial Pressure Determination, Transcutaneous
Lead sponsor: Milton S. Hershey Medical Center
Sponsor class: OTHER
First posted: 2022-12-07
Enrollment: 0
Sex: ALL
Minimum age (years): 5
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Infants

Brief summary: Subjects that are currently on a transcutaneous carbon dioxide monitor (TCOM) to monitor the carbon dioxide level in their blood will be placed on an additional TCOM using a non-adhesive sensor application ring instead of the usual adhesive ring to hold the TCOM sensor in place in order to evaluate usability of the non-adhesive applicator.


Eligibility criteria: Inclusion Criteria:

1. Premature or term birth newborn infants requiring transcutaneous monitoring
2. Thigh circumference of greater than 63mm
3. Weight greater than or equal to 600g
4. Ability of caretaker to understand verbal and written instructions and informed consent

Exclusion Criteria:

1. Absence of written informed consent.
2. Skin condition contraindicating transcutaneous measurements.
3. Thigh circumference less than or equal to 63 mm

Primary outcomes:
measure: Clinical Usability of a Novel Non-Adhesive Applicator for the Monitoring of tcPCO2 in Neonates
timeFrame: 3 Months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04205773: Epidural Catheter Location by Epidural Pressure Waveform
Official title: Confirmation of Epidural Catheter Location by Epidural Pressure Waveform Recordings by the CompuFlo Epidural Instrument
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthesia, Local
Lead sponsor: European e-Learning School in Obstetric Anesthesia
Sponsor class: OTHER
First posted: 2019-12-19
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Obstetric patients who received an epidural block and have an epidural catheter

Brief summary: The aim of this preliminary study was to evaluate the new CompuFlo instrument which allows pulsatile waveform recordings.

Detailed description: 30 epidural catheters previously successfully used for obstetric anesthesia or analgesia and about to be removed were tested. All patients were given 5 mL 2% lidocaine to test the catheter before its removal. After priming with 5 mL saline, the catheter was connected to CompuFlo to record the occurrence of pulsatile waveforms and/or their disappearance during its removal. The epidural catheter was marked at the skin level to record the distance between the skin at the time of measurements. The power analysis required a sample of 30 observations to set 80% test power and 95% significance level.

Eligibility criteria: Inclusion Criteria:

* Obstetric patients
* Must have an epidural catheter

Exclusion criteria

• Non-obstetric patients

Primary outcomes:
measure: pulsatile waveforms observation (presence or absence)
timeFrame: 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Roma
country: Italy
facility: EESOA Maternal Neonatal Simulation Centre
city: Rome
country: Italy
facility: Città di Roma Hospital
Study officials:
affiliation: European e-Learning School in Obstetric Anesthesia
name: Giorgio Capogna, MD
role: STUDY_DIRECTOR
References:
citation: Capogna G, Coccoluto A, Capogna E, Del Vecchio A. Objective Evaluation of a New Epidural Simulator by the CompuFlo(R) Epidural Instrument. Anesthesiol Res Pract. 2018 Jun 26;2018:4710263. doi: 10.1155/2018/4710263. eCollection 2018.