louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06901895: Comparing Effect of Hyaluronic Acid and Lipid Coated Carbomer Gel on Dry Eyes After Phacoemulsification in DP
Official title: Comparing Effect of Hyaluronic Acid and Lipid Coated Carbomer Gel on Dry Eyes After Phacoemulsification in Diabetic Patients
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Dry Eye
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2025-03-30
Enrollment: 64
Sex: ALL
Minimum age (years): 40
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: In this study we compare the curative effect of two lubricants Hylorunic acid and visol gel on dry eyes after phacoemulsification in diabetic patients. We check the tear film before operation and check post operate after 2nd week and 4th week of surgery. Its a hospital based study .


Eligibility criteria: Inclusion Criteria:

* Patients who have acute dry eye condition before phacoemulsification cataract surgery.

Exclusion Criteria:

* Patients who have chronic dry eye condition before phacoemulsification cataract surgery.

Primary outcomes:
measure: Schirmer test
timeFrame: 12 Months
measure: Tear Break up Test
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Shaheen welfare hospital
state: Punjab
Study officials:
References:
Clinical trial NCT05410795: Establishment and Verification of Pancreatic Volume Formula Based on Imaging
Official title: Establishment and Verification of Pancreatic Volume Formula Based on Imaging: A Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Healthy People
Chronic Pancreatitis
Acute Pancreatitis
Keywords: Magnetic resonance imaging
Pancreatic volume
Lead sponsor: Changhai Hospital
Sponsor class: OTHER
First posted: 2022-06-08
Enrollment: 300
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Inpatients meeting the eligibility criteria.

Brief summary: This study intends to construct the linear relationship between pancreatic volume and individual attributes (height, weight, width of anterior superior iliac spine, etc.), and to establish and verify the formula of pancreatic volume.

Detailed description: The volume of pancreas in healthy individuals changes with age. The pancreatic volume gradually increases from birth to 20 years old. There is a plateau period from 20 to 60 years old, and the volume gradually decreases after 60 years old. With the development of imaging technology, pancreatic volume can be measured by computer tomography and magnetic resonance imaging.

Whether it is pancreatic atrophy after chronic pancreatitis or pancreatic edema after acute pancreatitis, the pathological changes of pancreatic parenchyma may lead to changes in pancreatic volume. Many studies have confirmed that pancreatic volume can be used to evaluate the course of pancreatic related diseases such as diabetes and acute pancreatitis.

Therefore, the establishment of accurate and convenient pancreatic volume formula can help to estimate the initial pancreatic volume of patients. This study is helpful to evaluate the clinical stage, severity and prognosis of pancreatic related diseases.

Eligibility criteria: Inclusion Criteria (Meet 1 or 2 or 3):

* Healthy individuals (excluding pancreatic related diseases, such as acute and chronic pancreatitis, pancreatic trauma, pancreatic tumor, peripancreatic lesions, diabetes and other diseases that may affect the volume of the pancreas);
* Patients with chronic pancreatitis;
* Patients with acute pancreatitis within 144 hours after the onset of typical symptoms (severe persistent epigastric pain).

Exclusion Criteria:

* suspected to have malignant tumors;
* History of pancreas related surgery or minimally invasive treatment (such as pancreaticoduodenectomy, ERCP, etc.);
* acute exacerbation of chronic pancreatitis;
* pregnant or breastfeeding women;
* patients who refused to participate in the study.

Primary outcomes:
measure: Pancreatic volume
timeFrame: 14 days after MRI examination
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Changhai Hospital
Study officials:
affiliation: Changhai Hospital
name: Liang-hao Hu, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00607295: Efficacy and Safety of Clino-san on Vaginal Dryness of Breast Cancer Patients
Official title: Prospective Randomized Study on Efficacy and Safety of Clino-san® in the Management of Vaginal Dryness in Breast Cancer Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Breast Cancer
Vaginal Atrophy
Keywords: chemotherapy
hormonal therapy
urogenital atrophy
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2008-02-05
Enrollment: 98
Sex: FEMALE
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: 1. Although after treatment for breast cancer such as chemotherapy or hormonal therapy, urogenital atrophy is common, the patients are seldomly treated for several reasons. Management of this problem is important for improving quality of life.
2. "Clino-san" is a kind of vaginal lubricant with pH 5 which is similar pH of premenopausal vaginal discharge. After randomization of patients, they are treated with Clino-san or placebo 3 times/week for 12 weeks.
3. We check the vaginal symptoms, vag dryness severity score, and ultrasonography at baseline, 4, 8, and 12 weeks of treatment.


Eligibility criteria: Inclusion Criteria:

* breast cancer patients
* who are treated with chemotherapy or hormonal therapy
* who experience no menstruation after the previous therapy
* who complain of vaginal dryness

Exclusion Criteria:

* other cancer patients
* other severe disease
* poor compliance

Primary outcomes:
measure: vaginal dryness score
timeFrame: for 12 weeks
Secondary outcomes:
measure: sexual dysfunction
timeFrame: for 12 weeks
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Jae Weon Kim, MD, PhD
role: STUDY_DIRECTOR
References:
citation: Lee YK, Chung HH, Kim JW, Park NH, Song YS, Kang SB. Vaginal pH-balanced gel for the control of atrophic vaginitis among breast cancer survivors: a randomized controlled trial. Obstet Gynecol. 2011 Apr;117(4):922-927. doi: 10.1097/AOG.0b013e3182118790.
Clinical trial NCT06528795: The Effect of Hybrid Simulation-Based Lactation Consultancy Training on the Skills of Midwifery Students
Official title: The Effect of Hybrid Simulation-Based Lactation Consultancy Training on Midwifery Students' Psychosocial Care Competence and Communication Skills
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Breastfeeding Consultancy Training
Keywords: Hybrid Simulation
Midwifery Students
Psychosocial Care Competence
Communication Skill
Lead sponsor: Saglik Bilimleri Universitesi
Sponsor class: OTHER
First posted: 2024-07-30
Enrollment: 80
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Quasi-experimental randomized controlled trial
Primary purpose: SUPPORTIVE_CARE

Brief summary: This research was planned to examine the effects of hybrid simulation-based breastfeeding consultancy training on midwifery students' psychosocial care competence and communication skills. The research population will consist of second-year students studying at Health Sciences University (SBU), Hamidiye Faculty of Health Sciences (HSBF), Department of Midwifery in the spring semester of the 2023-2024 academic year (N: 80). Students participating in the study will be divided into intervention (n: 40) and control (n: 40) groups according to the computer-assisted simple random sampling technique. Control group students will practice on a simple breast model within the scope of classical education. "Descriptive Information Form", "Psychosocial Care Competency Self-Assessment Scale" and "Communication Skills Scale-Adult Form" will be applied to the students participating in the research.


Eligibility criteria: Inclusion Criteria:

* Volunteering to participate in research.
* Being an active student in the second year of the University of Health Sciences, Hamidiye Faculty of Health Sciences, Department of Midwifery.

Exclusion Criteria:

-Being a passive student in the second year of the University of Health Sciences, Hamidiye Faculty of Health Sciences, Department of Midwifery.

Primary outcomes:
measure: Introductory Information Form
timeFrame: 10 minutes
measure: Psychosocial Care Competence Self-Assessment Scale
timeFrame: 10 minutes
measure: Communication Skills Scale-Adult Form
timeFrame: 10 minutes
Secondary outcomes:
measure: Psychosocial Care Competence Self-Assessment Scale
timeFrame: 10 minutes
measure: Communication Skills Scale-Adult Form
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: University of Health Sciences
Study officials:
References:
Clinical trial NCT01960595: Post-operative Pain Management In Patients Undergoing Hullax Valgus Surgery
Official title: Comparison of the Efficacy and Cost Analysis of Regional Anesthesia and Intravenous Fentanyl for Postoperative Pain Management in Patients Undergoing Hullax Valgus Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Pain
Keywords: PCA,Nerve block,Hullax Valgus
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
First posted: 2013-10-10
Enrollment: 90
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate the efficacy and cost analysis of intravenous fentanyl combined with either local anesthesia infiltration or peroneal nerves block in patients with Hallux Valgus undergoing orthopedic corrective surgery and compared with patients without local anesthetics administration perioperatively.


Eligibility criteria: Inclusion Criteria:

1. patients with American Society of Anesthesiologists physical status I-III
2. aged 20-65 years
3. Requiring local anesthesia and PCA use
4. No severe cardiac or pulmonary diseases
5. BMI \<35 kg/m2

Exclusion Criteria:

1. BMI ≧35 kg/m2
2. age \> 65years
3. allergy to opioid or local anesthetics

Primary outcomes:
measure: provides adequate pain relief and decreases fentanyl consumption
timeFrame: including of surgery and 36 hours after surgery
Secondary outcomes:
measure: incidence of side effects and complications
timeFrame: intraoperatively and 36 hours after surgery
Other outcomes:
measure: assessment of cost analysis among groups
timeFrame: surgery period and 36 hours after surgery
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
Study officials:
affiliation: Department of orthopaedic surgery, Kaohsiung Medical University, Taiwan
name: Peng Ju Huang, MD, PhD.
role: STUDY_DIRECTOR
References:
Clinical trial NCT05311995: Which Trocar Access Site Should We Use in Laparoscopic Appendectomy?
Official title: Which Trocar Access Site Should We Use in Laparoscopic Appendectomy?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain
Keywords: Laparoscopy
Minimally invasive surgery
appendicitis
colorectal
Lead sponsor: Inonu University
Sponsor class: OTHER
First posted: 2022-04-05
Enrollment: 140
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Four trocar tecnıques groups in literature
Primary purpose: TREATMENT

Brief summary: Open appendectomy has been used in the treatment of appendicitis, which is among the most common emergency pathologies worldwide, since the end of the 19th century. In the 20th century, laparoscopic appendectomy came to the fore and the frequency of use increased gradually. Despite the frequency of laparoscopic appendectomy, there is no consensus on the best way to perform each procedural step. One of these steps is the trocar entry areas. In this study, investigator's aim is to compare the trocar entry areas, which are various reports in the literature, and to find the localization with the optimal usage area. 140 patients who underwent laparoscopic appendectomy between 2021-2022 were randomized into four groups and included in the study. Demographic data, peroperative findings, complications, length of stay and post-operative VAS values of the patients were evaluated.


Eligibility criteria: Inclusion Criteria:

* patients who underwent laparoscopic appendectomy

Exclusion Criteria:

patients who underwent open surgery and did not want to be involved in the study process

Primary outcomes:
measure: Pain Intensity measure
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Kayseri
country: Turkey
facility: Ersin Gundogan
state: Kocasinan
Study officials:
References:
Clinical trial NCT05946395: Comparison of Speech Therapy and Audioprosthetic Care in Older Adults With First-time Hearing Aids
Official title: Comparison of Synchronous or Delayed Speech Therapy and Audioprosthetic Care in Older Adults With First-time Hearing Aids
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Hearing Loss
Lead sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche
Sponsor class: OTHER
Collaborators: name: Euraxi Pharma
First posted: 2023-07-14
Enrollment: 0
Sex: ALL
Minimum age (years): 65
Maximum age (years): 80
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Patients will be randomly divided by drawing lots into 2 groups. Group A will benefit from speech therapy and synchronous equipment, and group B will begin speech therapy after 3 months after the installation of the equipment.
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to evaluate the score of the Evaluation of the Impact of Deafness in Adults(ERSA)/150 questionnaire obtained at 3 months compared to the inclusion score.

Detailed description: This is a pilot, prospective, interventional, comparative, randomized, longitudinal, open, multicenter study comparing synchronous and delayed hearing aid and speech therapy.

Patients will be randomly divided by drawing lots into 2 groups. Both groups will benefit from a hearing aid prescription and speech therapy for a series of 24 sessions at the rate of 1 per week, for an approximate duration of 6 months. Group A will benefit from speech therapy and synchronous equipment, and group B will begin speech therapy after 3 months after the installation of the equipment.

Regarding the equipment, it will not be the same for all patients. Indeed, it is the one that will best suit the patient who will be chosen. The same will apply to the settings, in accordance with the usual support.

Eligibility criteria: Inclusion Criteria:

* Patient, male or female, aged 65 to 80;
* First equipment;
* Average hearing loss between 40 and 70 db;
* Speech comprehension greater than 50%;
* Absence of acoustic recruitment phenomenon;
* Symmetrical bilateral deafness (inter aural difference \<20dB);
* Affiliated patient or beneficiary of a social security scheme;
* Patient speaking and understanding French, able to complete questionnaires and scales;
* Patient having been informed and having signed an informed consent to participate in the study.

Exclusion Criteria:

* Patient with a psychiatric pathology;
* Patient with neurological disorders;
* Patient taking psychotropic drugs;
* Patient participating in another clinical study;
* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision;
* Patient hospitalized without consent.

Primary outcomes:
measure: Assessment of the Impact of Deafness in Adults
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05677295: Therapeutic Efficacy in Women With Stress Urinary Incontinence
Official title: Comparisons of the Impact of Duloxetine Versus Imipramine on Therapeutic Efficacy in Women With Stress Urinary Incontinence: a Randomized Controlled Study.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Women With Stress Urinary Incontinence
Lead sponsor: Far Eastern Memorial Hospital
Sponsor class: OTHER
First posted: 2023-01-10
Enrollment: 90
Sex: FEMALE
Minimum age (years): 25
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: We will get the impact of duloxetine versus imipramine on therapeutic efficacy in women with SUI.

Detailed description: Background/Purpose: Pharmacologic treatments for female stress urinary incontinence (SUI) include duloxetine and imipramine. Duloxetine and Imipramine has been reported to have clinical significant therapeutic efficacy on female SUI and overactive bladder syndrome. However, there was no randomized controlled study to compare duloxetine and imipramine for the treatment of female SUI.

Patients and Methods: We will perform a prospective randomized controlled study to recruit 90 female SUI patients at the Obstetrics \& Gynecology outpatient clinic of Far Eastern Memorial Hospital. All SUI female patients will be asked to complete ICIQ-UI, USS, OABSS, and bladder diary before and after 4 weeks' duloxetine versus imipramine treatment.

Eligibility criteria: Inclusion Criteria:

* Female patients over 25 years old with stress urinary incontinence.
* Patients who are currently not considered for surgical treatment.
* Patients who have undergone regular Kegel exercises but have poor results.

Exclusion Criteria:

* The result of urodynamic examination, if the main cause of urinary incontinence is detrusor overactivity.
* Those who are taking or plan to take monoamine oxidase inhibitor (MAOI) inhibitors.
* Patients with acute myocardial infarction.
* Those who are allergic to duloxetine, imipramine and dibenzazepine tricyclic antidepressants.
* Patients with uncontrolled narrow-angle glaucoma.
* Pregnant women.
* Those who are contraindicated to duloxetine or imipramine.
* Patients with suicidal ideation and behavior.

Primary outcomes:
measure: Improvement of stress urinary incontinence
timeFrame: 4 weeks
Secondary outcomes:
measure: Improvement of urgency symptoms
timeFrame: 4 weeks
measure: Improvement of overactive bladder symptoms
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Banqiao
country: Taiwan
facility: Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital
state: New Taipei
Study officials:
References:
Clinical trial NCT02186795: Total Hip Arthroplasty Outcomes With Regional and Multimodal Analgesia
Official title: Improvement in Total Hip Arthroplasty Patient Outcomes With Regional Anesthesia and Multimodal Analgesia: A Retrospective Analysis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Arthroplasty
Replacement, Hip
Arthritis
Keywords: Arthroplasty
Replacement, Hip
Lead sponsor: Medical University of South Carolina
Sponsor class: OTHER
First posted: 2014-07-10
Enrollment: 117
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing primary total hip arthroplasty

Brief summary: The goal of this retrospective chart review is to evaluate if the implementation of lumbar plexus block placement for postoperative pain and administration of multimodal oral analgesia have improved conditions in the postoperative period for patients undergoing total hip arthroplasty when compared to the placement of epidurals for postoperative pain management.

Detailed description: Primary outcome: 48 hour opiate consumption in patients following THA. ' Secondary outcome: Time to first ambulation, assitstance needed with ambulation, opiate and regional related side effects, time to discharge orders.

Eligibility criteria: Inclusion Criteria:

1. Primary total hip arthroplasty, (identified by current procedural terminology (CPT) code 27130) and
2. Either a) Epidural or b) Lumbar plexus peripheral nerve block with the administration of multimodal medication after July 2012.

   -

   Exclusion Criteria:Exclusion criteria include THA Revision, ICU admission postoperatively, and dementia, not allowing pain score communication.

   -

Primary outcomes:
measure: Opiate Consumption
timeFrame: 48 hours postoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
Study officials:
affiliation: Medical University of South Carolina
name: Sylvia Wilson, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02948595: Video Feedback Versus Verbal Feedback
Official title: Video Feedback Versus Verbal Feedback in Simulated Laparoscopic Vaginal Cuff Closure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Resident Surgical Training
Lead sponsor: University of New Mexico
Sponsor class: OTHER
First posted: 2016-10-28
Enrollment: 19
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: The long term goal of our research is to develop a curriculum for Obstetrics and Gynecology resident physicians that regularly employs use of video assessment to improve surgical skills. Regular use of video feedback may enable improved self-assessment and allow for formal documentation of proficiency. The overall objective is to compare the use of video feedback to use of structured verbal feedback in the simulated task of laparoscopic vaginal cuff closure.


Eligibility criteria: Inclusion Criteria:

* Resident Physician in the Department of Obstetrics and Gynecology

Exclusion Criteria:

* Not a resident physician in the Department of Obstetrics and Gynecology

Primary outcomes:
measure: Improvement in ob/gyn resident physician self-efficacy as measured by self-efficacy questionnaire in video versus verbal feedback for simulated laparoscopic vaginal cuff closure
timeFrame: up to 18 months
Secondary outcomes:
measure: Improvement in time of simulated laparoscopic vaginal cuff closure with video versus verbal feedback
timeFrame: up to 18 months
measure: Improvement in skill of simulated laparoscopic vaginal cuff closure as measured by Objective Structured Assessment of Technical Skills (OSATS) global rating scale with video versus verbal feedback
timeFrame: up to 18 months
Other outcomes:
Locations:
Study officials:
References: