louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00907946: Comparing Previously Placed Nephrostomy Tract (NT) Versus Single Stage Percutaneous Nephrolithotomy (PCNL)
Official title: A Prospective, Randomized Trial Comparing Previously Placed Nephrostomy Tract and Single Stage Percutaneous Nephrolithotomy and Its Effects on Infection and Bleeding Related Complications
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Urolithiasis
Keywords: Renal stones
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2009-05-25
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The investigators are trying to determine whether placement of a nephrostomy tube prior to definitive stone surgery and under ultrasonic or fluoroscopic guidance will reduce complications related to bleeding and infection compare to obtaining renal access at the time of surgery.

Detailed description: We seek to identify whether the placement of a nephrostomy tract prior to surgery versus at the time of PCNL will: 1. decrease blood loss and related complications, and 2. decrease infection-related complications by providing the ability to an accurate collection of urine for culture and initiating appropriate antibiotic treatment prior to definitive stone management. In addition, we seek to determine whether renal puncture under fluoroscopic vs ultrasonic guidance is associated with less blood loss. Although retrospective studies have shown some benefit to placing the nephrostomy tube prior to surgery in terms of decreased blood loss, there are no well-designed, prospective studies comparing the two treatment approaches. We seek to determine which treatment approach is safer, more efficacious, and more cost-effective through a prospective, randomized trial.

Eligibility criteria: Inclusion Criteria:

* Patients age 18 years to 90 years old,
* Patients with stone disease
* Patients who hoose to have PCNL for treatment
* Patients who understand the informed consent

Exclusion Criteria:

* Minors
* Unable to understand the informed consent
* Unwilling to fill out the SF 36 questionnaire

Primary outcomes:
measure: Reduction of complications related to bleeding and infection
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University
state: Missouri
Study officials:
References:
Clinical trial NCT02596646: Early Precut in Difficult Biliary Cannulation
Official title: Early Precut Sphincterotomy During ERCP With Difficult Biliary Access (Italian: Esecuzione Del Pre-cut Precoce in Corso di ERCP Con Difficoltosa Incannulazione Della Via Biliare)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Common Bile Duct Diseases
Lead sponsor: Università Vita-Salute San Raffaele
Sponsor class: OTHER
Collaborators: name: San Giuseppe Moscati Hospital
name: Istituti Ospitalieri di Cremona
name: Valduce Hospital
name: Papa Giovanni XXIII Hospital
name: Cardarelli Hospital
name: Azienda Ospedaliera Universitaria Senese
name: Maresca Hospital
First posted: 2015-11-04
Enrollment: 375
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluates whether an early precut strategy in cases of difficult biliary cannulation could reduce the incidence of PEP compared with that after prolonged cannulation attempts. Secondary aims are to compare the success of biliary cannulation and complications rates of the two techniques.

Detailed description: In this prospective multicenter randomized clinical trial the investigators assign patients referred for therapeutic biliary ERCP and difficult biliary cannulation (unsuccessful cannulation after 5 minutes) to early precut (group A) or repeated papillary cannulation attempts followed, in case of failure, by late precut (group B). Group A patients undergo precut immediately after randomization ("early precut"), while for group B cannulation attempts are continued for another 10 minutes, after which a precut is done if these fail or there are three unintended additional passages of the guide-wire into the MPD ("delayed precut").

Eligibility criteria: Inclusion Criteria:

* 18 to 85 years of age who were scheduled to undergo therapeutic biliary ERCP.

Exclusion Criteria:

* active cholangitis or pancreatitis
* chronic pancreatitis,
* previous sphincterotomy,
* prior gastric surgery,
* coagulopathy,
* severe comorbidity (need for tracheal intubation)
* patients who refused or were unable to give informed consent.
* patients with successful CBD cannulation within 5 minutes of standard attempts and fewer than three passages of the guidewire into the main pancreatic duct (MPD) (arbitrarily defined as "easy CBD cannulation"),
* detection of ampulloma or peri-papillary diverticula during ERCP.

Primary outcomes:
measure: Incidence of PEP
timeFrame: 24 hours
Secondary outcomes:
measure: Incidence of overall complications
timeFrame: 24 hours
Other outcomes:
Locations:
city: Milan
country: Italy
facility: San Raffaele Hospital
Study officials:
affiliation: San Raffaele Hospital
name: Pier Alberto Testoni, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03286946: Detection of Intravascular Injection Between Blunt and Sharp Needles During Cervical Transforaminal Epidural Block.
Official title: The Difference of Intravascular Injection Rate During Cervical Transforaminal Epidural Block Using Blunt-type Block Needle Compared to Sharp-type Block Needle.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain
Radicular; Neuropathic, Cervical
Lead sponsor: Kyungpook National University Hospital
Sponsor class: OTHER
First posted: 2017-09-19
Enrollment: 108
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: This study evaluates the incidence of intravascular injection during cervical transforaminal epidural block using blunt needle, compared to the sharp needle. The investigators will performed cervical transforaminal epidural block using blunt-type block needle in half of participants or sharp-type block needle in the other half.

Detailed description: Cervical transforaminal epidural block is an effective treatment option of radiating pain. There are potential risks associated with transforaminal epidural block such as infection, dural puncture, bleeding, and intravascular injection. Although the risk is low, intravascular injection should be carefully monitored because intravascular injection of particulate steroids can cause fatal neurologic deficits such as spinal infarction and cerebral infarction.

The incidence of intravascular injection during transforaminal epidural block with real time fluoroscopy guidance depends on spinal level. The previous studies using real time fluoroscopy demonstrated that the incidence of intravascular injection of cervical transforaminal epidural block is higher than that of lumbosacral transforaminal epidural block.

In this study, therefore, the investigators investigate the incidence of intravascular injection during cervical transforaminal epidural block using blunt needle, compared to the sharp needle.

Eligibility criteria: Inclusion Criteria:

* Patients with radiating pain from cervical spinal stenosis and herniated nucleus pulposus.

Exclusion Criteria:

* Pregnancy, allergic to contrast media, patient refusal, and patients with persistent contraindication to nerve block such as coagulopathy and infection of the injection site.

Primary outcomes:
measure: Intravascular injection
timeFrame: During procedure
Secondary outcomes:
measure: Needling time
timeFrame: During procedure
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01092546: Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure Hydrocephalus
Official title: A Principal, Prospective, Open-label Biopsy Study to Validate Detection of Cerebral Cortical Amyloid With Flutemetamol (18F) Injection in Normal Pressure Hydrocephalus (NPH) Subjects.
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Normal Pressure Hydrocephalus
Keywords: Amyloid
Normal pressure hydrocephalus (NPH)
Positron Emission Tomography (PET)
Standard uptake value ratios (SUVR)
Lead sponsor: GE Healthcare
Sponsor class: INDUSTRY
Collaborators: name: i3 Statprobe
First posted: 2010-03-25
Enrollment: 12
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: To determine the level of association between the quantitative estimates of brain uptake of \[18F\]flutemetamol and the quantitative immunohistochemical and histochemistry estimates of amyloid levels in frontal lobe biopsy samples obtained from subjects during shunt placement for NPH.


Eligibility criteria: Inclusion Criteria:

* The subject is at least 50 years of age.
* The subjects' general health is adequate to comply with study procedures.
* The subject has been scheduled for a shunt placement procedure for the treatment of NPH.

Exclusion Criteria:

* The subject has a contraindication for MRI or PET.
* The subject is pregnant or lactating.
* The subject has a known or suspected hypersensitivity/allergy to \[18F\]flutemetamol or to any of the excipients.
* The subject has participated in any clinical study using an investigational agent within 30 days of dosing.

Primary outcomes:
measure: Standard Uptake Value Ratio (SUVR) at the Site of the Biopsy Based on the "Cerebellum" (CER) as the Reference Region.
timeFrame: Post flutemetamol Injection
Secondary outcomes:
measure: Standard Uptake Value Ratio (SUVR) at the Site of the Biopsy Based on the "Pons" as the Reference Region.
timeFrame: Post flutemetamol administration
Other outcomes:
Locations:
city: Princeton
country: United States
facility: GE Healthcare
state: New Jersey
Study officials:
affiliation: GE Healthcare
name: Kim A Mansfield, MS
role: STUDY_DIRECTOR
References:
Clinical trial NCT06722846: Communicating Health Options to Inform Care and Empower Strategic Care Planning (CHOICES): A Multi-layer Randomized Case Vignette Study.
Official title: Communicating Health Options to Inform Care and Empower Strategic Care Planning (CHOICES): A Multi-layer Randomized Case Vignette Study.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Health Options
Strategic Care Planning
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
First posted: 2024-12-09
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: MD Anderson Cancer Center

Brief summary: To learn more about how the delivery of medical information affects therapy choices for participants with advanced forms of cancer.

Detailed description: Primary Objectives • To examine how provision of medical information (risks, benefits, time toxicity, prognosis, oncologists' recommendation, and costs) affects preference for palliative systemic therapy in participants with advanced cancer.

Secondary Objective

• To examine how different options of medical information (risks/benefits, time toxicity, prognosis, oncologists' recommendation, and costs) affect preference for palliative systemic therapy in participants with advanced cancer.

Exploratory Objective

* To examine how the order of presentation of medical information affects preference for palliative systemic therapy in participants with advanced cancer.
* To examine the association between intrinsic participants characteristics (such as participants demographics, symptoms, anxiety, depression, illness understanding, acceptance, coping strategies, religious coping, hope, decision making style, trust in oncologist, financial distress) and preference for palliative systemic therapy in participants with advanced cancer.

Eligibility criteria: Inclusion Criteria:

Diagnosis of advanced solid tumor (i.e. metastatic, relapsed, and/or incurable disease) or aggressive lymphoma.

* Age 18 or greater
* Seen at MD Anderson Cancer Center Thoracic and Lymphoma Oncology Clinics for a follow-up visit
* Been treated with at least 2 lines of palliative systemic cancer therapies

Exclusion Criteria:

* Diagnosis of cognitive impairment or dementia requiring a surrogate decision maker
* Non-English speaking

Primary outcomes:
measure: Overall Survival (OS)
timeFrame: Through study completion; an average of 1 year.
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: MD Anderson Cancer Center
state: Texas
Study officials:
affiliation: M.D. Anderson Cancer Center
name: David Hui, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01211912: Acetaminophen Transfer Across the Placenta and the Assessment of Fetal Well-being
Official title: Acetaminophen Transfer Across the Placenta and the Assessment of Fetal Well-being
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Fetal Testing
Transplacental Transfer of Acetaminophen
Keywords: Fetal movement
Fetal breathing
Acetaminophen
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2010-09-30
Enrollment: 56
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 44
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: This study has two aims:

1. to evaluate placental transfer of acetaminophen from mother to baby transplacentally given from 30 minutes to 24 hours prior to cesarean delivery (34 patients)
2. to understand the impact of maternal acetaminophen use on fetal movement and breathing (20 patients)


Eligibility criteria: Inclusion Criteria

* Pregnant females
* Age 18-44
* Any race
* Any parity
* Singleton Gestations
* Weight between 60-90 kg

Exclusion Criteria

* Acetaminophen Allergy
* Contraindication to Acetaminophen Use
* Chorioamnionitis
* Preeclampsia
* Diabetes Mellitus
* Placental Abruption
* Placenta Previa
* Fetal Anomaly
* Intrauterine growth restriction (IUGR)
* Multiple Gestations
* Maternal Medical Disease
* Acetaminophen use in the last 3 days
* Plan to donate or bank fetal cord blood

Primary outcomes:
measure: Maternal and neonatal serum acetaminophen level
timeFrame: Time Frame: 30 minutes to 24 hours post administration
measure: Fetal breathing and body movements
timeFrame: Time Frame: 60 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Brian C Brost, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04866212: Comparison of Manual Skills, Visual-Motor Integration and Participation of Children With and Without Type 1 Diabetes
Official title: Comparison of Hand Skills, Visual-Motor Integration and Participation in Activities of Daily Living of Children With and Without Type 1 Diabetes
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Type 1 Diabetes
Hand Skills
Visual Motor Integration
Participation
Lead sponsor: Istanbul Medipol University Hospital
Sponsor class: OTHER
First posted: 2021-04-29
Enrollment: 89
Sex: ALL
Minimum age (years): 8
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children with T1DM followed in Istanbul Medipol Mega University Hospital Pediatric Endocrinology Polyclinic. Healthy children and their parents will be selected from primary and secondary schools near the hospital.

Brief summary: The aim of this study is to compare visual-motor integration, academic achievement and participation in activities of daily living with and without type 1 diabetes.

Detailed description: There are two different groups in this study. The first group includes children with type 1 diabetes and the second group includes healthy children. Children aged 8-12 years were included in the evaluation. Beery-Buktenica Developmental Test of Visual Motor Integration , academic achievement (Turkish, mathematics, social sciences exam scores) Participation and Environment Measure-Children an Youth, Jebsen Taylor Hand Function Test were used for evaluation.

Eligibility criteria: Inclusion Criteria:

1. Being between the ages of 8 and 12,
2. To be diagnosed with Type 1 diabetes,
3. To be receiving education at primary education level,
4. Children who agree to participate in the cooperative during the evaluations,
5. Parents and children accepted to participate in the study.

Exclusion Criteria:

1. Any acute or chronic illness that affects the level of physical activity,
2. Other types of diabetes,
3. Mental problems,
4. Having received psychiatric treatment,
5. Having vision problems.

Primary outcomes:
measure: Visual Motor Integration
timeFrame: 30 minutes
measure: Hand Skills
timeFrame: 10-15 minutes
measure: Participation
timeFrame: 25-40 minutes
measure: academic achievement
timeFrame: 1 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Medipol University
state: Beykoz
Study officials:
References:
Clinical trial NCT06076512: Pain Clinic Provides Public Health Safety
Official title: Pain Clinic Provides Public Health and Safety Services
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Social Functioning
Addiction, Substance
Safety Issues
Road Injury
Patient Compliance
Chronic Pain
Lead sponsor: Salem Anaesthesia Pain Clinic
Sponsor class: OTHER
First posted: 2023-10-10
Enrollment: 1000
Sex: ALL
Minimum age (years): 20
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult chronic pain patients who are undergoing treatment in a specialist pain clinic

Brief summary: Chronic pain is associated with psychological disorders; which may affect a patient's socioeconomic, legal, domestic, and employment situations. This prospective observational study evaluates the impact of pain management on patients' health, social, economic, and employment status. It explores the impact of pain clinic services on patients' mental health, family health, public health, road safety, addiction situation, public safety, injury rehabilitation and employment situation.

Detailed description: Chronic pain is associated with many behavioral or psychological disorders. The psychological disorders may have negative impact on the patient's social, economic, health, legal, domestic, relationship and employment situations.

This prospective observational study evaluates the impact of pain management services on the patients' health, social, economic, and employment status. The clinical study explores the impact of pain clinic services on patients' mental health, childcare, family health, public health, road safety, addiction situation, public safety, injury rehabilitation, employment status and housing situation.

Eligibility criteria: Inclusion Criteria:

* adult chronic pain patients
* patients with psychosocial problems

Exclusion Criteria:

* pediatric patients
* patients with severe cognitive dysfunction

Primary outcomes:
measure: Percentage of patients who had psychosocial problems
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Surrey
country: Canada
facility: Salem Anaesthesia Pain Clinic
state: British Columbia
Study officials:
affiliation: Salem Anaesthesia Pain Clinic
name: Olu Bamgbade, MD,FRCPC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06865612: A Comparative Analysis of Preoperative Liver Volumetry in Living Donor Liver Transplantation
Official title: Optimizing Accuracy: a Comparative Analysis of Preoperative Liver Volumetry in Living Donor Liver Transplantation from a Surgeon's Perspective
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Living Donor Liver Transplantation
Liver Failure
Lead sponsor: Chungnam National University Hospital
Sponsor class: OTHER
First posted: 2025-03-10
Enrollment: 109
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study includes patients who underwent hepatectomy for living donor liver transplantation performed at Chungnam National University Hospital. Data will be retrospectively reviewed to compare preoperative estimated graft volume (EGV) to actual graft weight (AGW).

Brief summary: Accurate preoperative graft volume assessment is crucial for successful living donor liver transplantation (LDLT). Although manual and automated computed tomography (CT) volume measurement methods using various volumetric tools are widely used, their accuracy remains uncertain. This study aimed to determine the optimal dry weight correction factor for each method to enhance the prediction of actual graft weight (AGW) and compare the accuracy of different methods.

Detailed description: This study is a retrospective diagnostic accuracy study comparing three liver volumetry methods using preoperative donor CT scans in LDLT.

Eligibility criteria: Inclusion Criteria:

* Patients who underwent hepatectomy for living donor liver transplantation performed by the Department of Surgery at Chungnam National University Hospital under the supervision of the principal investigator.

Exclusion Criteria:

* Patients deemed unsuitable for participation in this clinical study by the investigator.

Primary outcomes:
measure: Accuracy of preoperative estimated graft volume (EGV) compared to actual graft weight (AGW)
timeFrame: From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)
Secondary outcomes:
measure: Determination of the optimal dry weight correction factor for each volumetry method
timeFrame: From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)
Other outcomes:
Locations:
city: Daejeon
country: Korea, Republic of
facility: Chungnam National University Hospital
Study officials:
References: