Clinical trial NCT01871272: Knee Arthroscopy Cohort Southern Denmark (KACS)
Official title: Knee Arthroscopy Cohort Southern Denmark (KACS)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Meniscus Injury
Knee Osteoarthritis
Lead sponsor: University of Southern Denmark
Sponsor class: OTHER
Collaborators: name: Odense University Hospital
name: Lillebaelt Hospital, Kolding and Vejle, Denmark
First posted: 2013-06-06
Enrollment: 491
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients assigned for arthroscopy on suspicion of a meniscus tear in the period from February 1st 2013 to January 31st 2014 will be consecutively recruited to the KACS cohort from 4 different hospitals (Lillebaelt Hospital - Kolding and Vejle and Odense University Hospital - Odense and Svendborg) in the Region of Southern Denmark.

Brief summary: PURPOSE: To investigate the natural time course of patient-reported outcomes after meniscus surgery and identify factors associated with good and bad outcome after surgery.


Eligibility criteria: Inclusion Criteria:

* Assigned for arthroscopy on suspicion of a medial and/or lateral meniscus tear.
* Age \>18 years at time of recruitment
* Having an email address
* Able to read and understand Danish

Exclusion Criteria:

* Patients who will or have previously undergone surgical reconstruction of the anterior or posterior cruciate ligament (ACL or PCL) in either knee
* Fracture to the lower extremities (i.e. hip, leg or foot) in either leg within the last 6 months prior to recruitment
* Not mentally able to reply to the questionnaire

Primary outcomes:
measure: Knee Injury and Osteoarthritis Outcome Score (KOOS)
timeFrame: PRE surgery (assessed 1-14 days prior to surgery) and at 12 weeks and 52 weeks follow-up
Secondary outcomes:
measure: Medical Outcomes Study 36-Item Short Form Health Survey (SF-36)
timeFrame: PRE surgery (assessed 1-14 days prior to surgery) and at 12 weeks and 52 weeks follow-up.
measure: Patient Acceptable Symptom State (PASS)
timeFrame: At 12 weeks and 52 weeks follow-up.
measure: Treatment failure (TF)
timeFrame: At 12 weeks and 52 weeks follow-up.
Other outcomes:
measure: Global perceived effect (GPE)
timeFrame: At 12 weeks and 52 weeks follow-up.
Locations:
city: Kolding
country: Denmark
facility: Department of Orthopedics, Lillebaelt Hospital
state: Southern Denmark
city: Odense
country: Denmark
facility: Department of Orthopedics and Traumatology, Odense University Hospital
state: Southern Denmark
city: Svendborg
country: Denmark
facility: Department of Orthopedics and Traumatology, Odense University Hospital
state: Southern Denmark
city: Vejle
country: Denmark
facility: Department of Orthopedics, Lillebaelt Hospital
state: Southern Denmark
Study officials:
affiliation: Department of Sports Science and Clinical Biomechanics, University of Southern Denmark
name: Jonas B Thorlund, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Thorlund JB, Christensen R, Nissen N, Jorgensen U, Schjerning J, Porneki JC, Englund M, Lohmander LS. Knee Arthroscopy Cohort Southern Denmark (KACS): protocol for a prospective cohort study. BMJ Open. 2013 Oct 14;3(10):e003399. doi: 10.1136/bmjopen-2013-003399.
citation: Giladi JO, Holsgaard-Larsen A, Varnum C, Thorlund JB. Sports Participation and Performance 5 Years After Arthroscopic Partial Meniscectomy: A Retrospective Cohort Study of 288 Patients. J Orthop Sports Phys Ther. 2022 Apr;52(4):224-232. doi: 10.2519/jospt.2022.10785.
citation: Pihl K, Ensor J, Peat G, Englund M, Lohmander S, Jorgensen U, Nissen N, Fristed JV, Thorlund JB. Wild goose chase - no predictable patient subgroups benefit from meniscal surgery: patient-reported outcomes of 641 patients 1 year after surgery. Br J Sports Med. 2020 Jan;54(1):13-22. doi: 10.1136/bjsports-2018-100321. Epub 2019 Jun 11.
citation: Thorlund JB, Pihl K, Nissen N, Jorgensen U, Fristed JV, Lohmander LS, Englund M. Conundrum of mechanical knee symptoms: signifying feature of a meniscal tear? Br J Sports Med. 2019 Mar;53(5):299-303. doi: 10.1136/bjsports-2018-099431. Epub 2018 Aug 31.
citation: Thorlund JB, Englund M, Christensen R, Nissen N, Pihl K, Jorgensen U, Schjerning J, Lohmander LS. Patient reported outcomes in patients undergoing arthroscopic partial meniscectomy for traumatic or degenerative meniscal tears: comparative prospective cohort study. BMJ. 2017 Feb 2;356:j356. doi: 10.1136/bmj.j356.