Clinical trial NCT02785510: Determining Clinical Profile of Parkinson's Disease Among Egyptian Population
Official title: Determining Clinical Profile of Parkinson's Disease Among Egyptian Population
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Parkinson's Disease
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
First posted: 2016-05-27
Enrollment: 500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who meet the diagnosis of Parkinson's disease according to the Parkinson's disease criteria of United Kingdom Brain Bank.

Brief summary: Parkinson's disease is the second most common neurodegenerative disease affecting about 1-3% of population above 60 years. Recently, non-motor symptoms are getting more attention in PD management. The pattern of PD onset and clinical course differ from one population to another. Many studies have been conducted to determine the clinical profile of PD in populations worldwide. However, no similar studies have been conducted in Egypt. Therefore, the investigators will conduct a nation-wide, collaborative, cross sectional study to determine the pattern of Parkinson's disease onset, clinical course, and non-motor symptoms among Egyptian population.


Eligibility criteria: Inclusion Criteria:

* Patients who meet the Parkinson's disease criteria of United Kingdom Brain Bank within the study centres.

Exclusion Criteria:

* Patients with vascular Parkinsonism (history of stroke)
* Patients with treatment induced Parkinsonism
* Patients with history of dopaminergic neurotoxin (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)

Primary outcomes:
measure: Age at disease onset
timeFrame: At enrolment
measure: Time to diagnosis
timeFrame: At enrolment
measure: Initial motor symptom
timeFrame: At enrolment
measure: Side of initial motor symptoms
timeFrame: At enrolment
measure: Clinical subtype of the disease
timeFrame: At enrolment
measure: Duration of levodopa treatment from disease onset
timeFrame: At enrolment
measure: Levodopa equivalent dose
timeFrame: At enrolment
measure: Non-motor symptoms
timeFrame: At enrolment
measure: Quality of life
timeFrame: At enrolment
Secondary outcomes:
measure: Stage of the disease [optional]
timeFrame: At enrolment
measure: Motor Functions [optional]
timeFrame: At enrolment
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: National Liver Institute
Study officials:
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