Clinical trial NCT02753023: Registry Of Acute meDical Emergencies in Brazil
Official title: Registry Of Acute meDical Emergencies in Brazil - ROAD-Brazil
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Coronary Syndromes
Heart Failure
Pulmonary Edema
Aortic Aneurysm, Familial Thoracic 1
Chest Pain
Pulmonary Embolism
Syncope
Lead sponsor: University of Sao Paulo General Hospital
Sponsor class: OTHER
First posted: 2016-04-27
Enrollment: 1650
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: emergency unit patients

Brief summary: Critical patients in emergency room are seriously situations that need quickly diagnosis and treatment. Different predictors of prognosis can be related with mortality and morbidity in-hospital and in long-term. In Brazil, this kind of registry is not available. The aim of the study is analysis and report data about critical patients in Emergency Departments over all country, showing demographic, clinical and prognosis data about that in Brazil.

Detailed description: This will be a prospective and multicentric data-bank registry. Initially, all patients with acute coronary syndromes (ACS), acute decompensated heart failure (ADHF), warfarin intoxication, acute pulmonary edema, acute aortic dissection, chest pain, pulmonary embolism and syncope will be included. There will be not exclusion criteria. The inclusion criteria will be followed by definition of each illness described in recent guidelines. Investigators estimated annually over than 500 cases with ACS/chest pain, 300 cases of ADHF, 200 cases of aortic dissection, 200 of pulmonary embolism, 200 cases of warfarin intoxication, 100 cases of syncope and 150 of acute pulmonary edema. Clinical data, electrocardiographic and echocardiographic findings, laboratory results and prognosis will be related. Routine of treatment will be defined by each center. The analysis includes minimum, medium and maximum values. Variables will be adjusted according with each diagnosis and all data will be included using the REDCap digital data entry. Probabilities will be determined by logistic regression and will be considered significate when p \< 0.005. Prospectively, investigators will use the Cox model to calculate associations.

Eligibility criteria: Inclusion Criteria:

* all patients with:
* acute coronary syndromes (ACS) or,
* acute decompensated heart failure (ADHF) or,
* warfarin intoxication or,
* acute pulmonary edema or,
* acute aortic dissection or,
* chest pain or,
* pulmonary embolism or
* syncope.

Exclusion Criteria:

-There will be not exclusion criteria.

Primary outcomes:
measure: mortality
timeFrame: 6 months
Secondary outcomes:
measure: mortality
timeFrame: 12 months
Other outcomes:
Locations:
city: Vitória
country: Brazil
facility: Pronto Socorro - Hospital Metropolitano
state: Espírito Santo
city: Santo André
country: Brazil
facility: Unidade Coronariana do Hospital Estadual Mario Covas
state: São Paulo
city: Sorocaba
country: Brazil
facility: Hospital Unimed Sorocaba
state: São Paulo
city: São Paulo
country: Brazil
facility: Instituto do Coração - HMFMUSP
city: São Paulo
country: Brazil
facility: Pronto Atendimento - Hospital Alemão Oswaldo Cruz
city: São Paulo
country: Brazil
facility: Pronto Socorro - Hospital TotalCor
Study officials:
References: