Clinical trial NCT00096876: A Study of the Sense of Smell in Relatives of Parkinson's Disease Patients
Official title: Screening Evaluations for Neurologic Syndromes: Olfactory Testing in Relatives of Parkinson's Disease Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Parkinson Disease
Parkinsonian Syndrome
Keywords: Parkinsonian syndrome
Lead sponsor: Institute for Neurodegenerative Disorders
Sponsor class: OTHER
First posted: 2004-11-17
Enrollment: 600
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE

Brief summary: In this study, individuals complete and return a mail survey, specifically a 40 item scratch and sniff smell test.

Detailed description: This study would extend the findings of previous studies by characterizing the performance of the 40-item UPSIT in a cohort of first-degree relatives of Parkinson's disease (PD) patients. The results would also validate the use of the University of Pennsylvania Smell Identification Test (UPSIT) as a mail-survey instrument. Once identified, these individuals could be followed as a potentially at-risk cohort to determine if the screening evaluation was predictive of later developing Parkinson's disease. The results from this pilot study have the potential to guide the use of olfactory testing using the UPSIT as a screening tool, and to provide necessary preliminary data for planning clinical trials to prevent the occurrence of PD in at-risk individuals.

Eligibility criteria: Inclusion Criteria:

* Subject must be a first-degree relative of a PD patient with diagnosis confirmed by a movement disorders specialist at the Institute for Neurodegenerative Disorders
* Subject must not carry a diagnosis of PD or other neurodegenerative disorder
* Subject must be either at least 50 years old or within 10 years of the age of onset of their affected relative
* Subject must be a non-smoker
* Subject must have no other known reason for abnormal olfaction (e.g. nasal trauma)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Institute for Neurodegenerative Disorders
state: Connecticut
Study officials:
affiliation: Institute for Neurodegenerative Disorders
name: Danna Jennings, MD
role: PRINCIPAL_INVESTIGATOR
References:
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