Clinical trial NCT05697523: Multiple Sclerosis and Respiratory and Functional Capacity
Official title: Comparison of Respiratory, Physical Activity and Functional Capacities of Patients wıth Mild Relapsing Remitting Multiple Sclerosis and Healthy Controls
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Multiple Sclerosis
Keywords: Multiple Sclerosis
functional capacity
physical activity
respiratory system
Relapsing-Remitting
Lead sponsor: Nigde Omer Halisdemir University
Sponsor class: OTHER
Collaborators: name: Pamukkale University
First posted: 2023-01-26
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Multiple Sclerosis patients who applied to Pamukkale University Hospital Neurology Clinic were included in this study.

Brief summary: It is known that respiratory functions, physical activities and functional capacities of Multiple Sclerosis (MS) patients decrease with the progression of the disease. However, there is not enough information about the severity of the effects of these parameters in mild Relapsing-Remitting Multiple Sclerosis (RRMS) patients. Our aim in this study is to compare the respiratory functions, physical activities and functional capacities of mild RRMS patients with healthy controls and to examine the relationship between them.

Detailed description: It is known that respiratory functions, physical activities and functional capacities of Multiple Sclerosis (MS) patients decrease with the progression of the disease. However, there is not enough information about the severity of the effects of these parameters in mild Relapsing-Remitting Multiple Sclerosis (RRMS) patients. Our aim in this study is to compare the respiratory functions, physical activities and functional capacities of mild RRMS patients with healthy controls and to examine the relationship between them.

Forty individuals diagnosed with RRMS between the ages of 18-60 and 40 healthy individuals with similar demographic characteristics were included in the study.

Eligibility criteria: Patient group - Inclusion Criteria:

* Having a definitive diagnosis of RRMS according to the 2017 McDonald criteria
* Being between the ages of 18-60.
* To be willing to participate in the study.
* EDSS score between 0-3.

Healthy group - Inclusion Criteria:

* Being between the ages of 18-60.
* To be willing to participate in the study.

Patient group - Exclusion Criteria:

* Have other neurological, orthopedic and systemic problems
* Having a relapse 30 days before or during the study
* Changes in medication use in the past 30 days

Healthy group - Exclusion Criteria:

* Have neurological, orthopedic and systemic problems

Primary outcomes:
measure: Pulmonary Function Tests- FEV1/FVC
timeFrame: Baseline
measure: Pulmonary Function Tests- FVC
timeFrame: Baseline
measure: Pulmonary Function Tests- FEV1
timeFrame: Baseline
measure: Pulmonary Function Tests- PEF
timeFrame: Baseline
measure: Pulmonary Function Tests- MVV
timeFrame: Baseline
measure: Functional Capacity
timeFrame: Baseline
measure: International Physical Activity Questionnaire - Short Form
timeFrame: Baseline
Secondary outcomes:
measure: Expanded Disability Status Scale
timeFrame: Baseline
Other outcomes:
Locations:
city: Denizli
country: Turkey
facility: Pamukkale University
Study officials:
References: