Clinical trial NCT04017182: Correlation Between External Jugular Venous and Superior Vena Cava Central Venous Blood Oxygen Saturation in Patient Under General Anesthesia
Official title: Correlation Between External Jugular Venous and Superior Vena Cava Central Venous Blood Oxygen Saturation in Patient Under General Anesthesia
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Central Venous Oxygen Saturation
Keywords: central venous oxygen saturation
external jugular venous oxygen saturation
central venous catheter
external jugular vein
internal jugular vein
superior vena cava oxygen saturation
Lead sponsor: Ramathibodi Hospital
Sponsor class: OTHER
First posted: 2019-07-12
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult surgical patients undergoing surgery under general anesthesia in institutional operating theaters with superior vena cava central venous catheter installation anticipated.

Brief summary: After installation of central venous catheter in patients under general anesthesia, paired sample of superior vena cava central venous blood and right external jugular venous blood will be collected and send to central laboratory for venous blood gas analysis. Correlation between superior vena cava central venous blood and right external jugular venous blood oxygen saturation will be determined as primary outcome.

Detailed description: All patients age between 18-65 year old who undergoing surgery under general anesthesia and superior vena cava central venous catheter installation anticipated are eligible. The tips of superior vena cava central venous catheter was confirmed by Chest x-ray. Next 1 hour after skin incision, 1 ml of venous blood sample is taken from superior vena cava central venous catheter of right external jugular vein then send to central laboratory for venous blood gas analysis. The demographic data will be recorded. Correlation between superior vena cava central venous blood and right external jugular venous blood oxygen saturation will be determined the primary outcome and partial pressure of carbon dioxide will be determined as a secondary outcome.

Eligibility criteria: Inclusion Criteria:

* Written consent obtained from patient or next of kin a day before operation date
* Patient age between 18-65 years old undergoing syrgery under general anesthesia
* Superior vena cava central venous catheter anticipated for CVP mesurement, innotropic or vasopressor administration,pulmonary artery catheter insertion route
* Anticipated right external jugular venous sampling time less than 5 minutes
* The site of blood sample collection easily access during operation

Exclusion Criteria:

* No jugular central venous catheter installation or other route selected
* Duration of paired sample collection more than 10 minutes
* Can not collected blood sample from right external jugular vein within 3 attemps
* The site of blood sample collection difficulty access during operation
* Pateint or next of kin refuse to participate

Primary outcomes:
measure: Correlation of venous oxygen saturation
timeFrame: 1 hour
Secondary outcomes:
measure: Correlation of venous partial pressure of carbon dioxide
timeFrame: 1 hour
measure: Relationship between superior vena cava central venous and external jugular venous oxygen saturation
timeFrame: 1 hour
Other outcomes:
Locations:
city: Bankok
country: Thailand
facility: Department of Anesthesiology, Ramathibodi Hospital
state: Bangkok
Study officials:
References: