louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00745862: Illness Related Distress in Women With Clinically Localized Cutaneous Melanoma
Official title: Illness Related Distress in Women With Clinically Localized Cutaneous Melanoma
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Melanoma
Keywords: Skin
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2008-09-03
Enrollment: 118
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Female melanoma patients during their regularly scheduled surgical clinic appointment at MSKCC.

Brief summary: The purpose of this study is to examine the experiences and quality of life of women who have been treated for melanoma. By quality of life, we mean how they are feeling about different aspects of their life. In this study, we are especially interested in their feelings about survival, physical appearance and any family concerns. We will administer a series of QOL questionnaires, data sheets with many questions, to get their response to measure their feelings about these issues.


Eligibility criteria: Inclusion Criteria:

* Age 18 years or older
* Clinically node-negative primary cutaneous melanoma.
* Patients participating must be female
* Patients must have completed surgical treatment for melanoma at least 10 days ago and less than 2 years at the time of study entry.

Exclusion Criteria:

* Prior history of cancer with the exception of squamous or basal cell carcinoma of the skin.

Primary outcomes:
measure: To measure illness related distress regarding survival, family planning and functioning, and aesthetic satisfaction and QOL in post-surgical female patients diagnosed with clinically localized primary cutaneous melanoma.
timeFrame: conclusion of study
Secondary outcomes:
measure: To examine the impact of illness related distress on QOL in women treated for clinically localized primary cutaneous melanoma.
timeFrame: conclusion of study
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan-Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Mary Sue Brady, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Atkinson TM, Noce NS, Hay J, Rafferty BT, Brady MS. Illness-related distress in women with clinically localized cutaneous melanoma. Ann Surg Oncol. 2013 Feb;20(2):675-9. doi: 10.1245/s10434-012-2635-5. Epub 2012 Sep 11.
Clinical trial NCT00546962: Tissue Bank for Pulmonary Diseases
Official title: Tissue Bank for Pulmonary Diseases
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cystic Fibrosis
Lead sponsor: Boston Children's Hospital
Sponsor class: OTHER
Collaborators: name: Harvard University
First posted: 2007-10-19
Enrollment: 400
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cystic Fibrosis Patients, Pulmonary Patients

Brief summary: The aim of this research study is to collect and store the specimens that are left over after patients undergo tests ordered by their physicians. These specimens will be used at a later time by researchers in the Pulmonary Division to develop a better understanding of pulmonary diseases or for the development of new treatments. Typical research studies that will be conducted on the stored tissue, fluid, or bacteria from the patient sample involve obtaining bacterial cultures, measurement of inflammatory markers, and examination of the characteristics of the tissue. Other similar tests may be done in the future; however, these tests have not all been determined at this time. It is important to note that no genetic testing will be performed on any samples that are obtained as part of this protocol.


Eligibility criteria: Inclusion Criteria:

* Open

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Children's Hospital
state: Massachusetts
Study officials:
affiliation: Boston Children's Hospital
name: Thomas Martin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06051162: HPI Effect in Robotic Urological Surgery on AKI
Official title: Effect of Use of Hypotension Prediction System in Prevention of Postoperative Acute Kidney Injury in Robotic-assisted Urologic Surgery
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Prostate Cancer
Renal Cancer
Urologic Diseases
Keywords: Robotic
Lead sponsor: Ewha Womans University Mokdong Hospital
Sponsor class: OTHER
First posted: 2023-09-22
Enrollment: 124
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: It is a single-center randomized controlled trial that aims to figure out the effect of the hypotension prediction index (HPI) on the prevention of acute kidney injury (AKI) after robot-assisted urological surgery. The primary hypothesis is that HPI software guidance prevents postoperative AKI by reducing the duration and severity of intraoperative hypotension (IOH).


Eligibility criteria: Inclusion Criteria:

* Age ≧ 19
* Patients undergoing robot-assisted urological surgery

Exclusion Criteria:

* Unable to voluntarily give consent
* Unable to use both radial arteries due to such reasons: prior surgery on the radial artery, breast cancer history with axillary LN dissection, AV fistula for renal replacement therapy, or abnormal Allen's test.

Primary outcomes:
measure: Acute kidney injury
timeFrame: Seven day after the operation
Secondary outcomes:
measure: Depth and duration of hypotension
timeFrame: From applying HPI (hypotension prediction index) monitor to the arterial line to the end of the anesthesia
measure: Hypotension prediction index
timeFrame: From applying HPI (hypotension prediction index) monitor to the arterial line to the end of the anesthesia
measure: Biomarkers
timeFrame: Baseline, immediate postop
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Ewha Womans University Mokdong Hospital
Study officials:
References:
Clinical trial NCT00272480: Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial
Official title: Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: HTLV-I-associated Myelopathy
Keywords: HAM/TSP
HTLV-I-associated myelopathy
zidovudine
lamivudine
antiretroviral therapy
Lead sponsor: Imperial College London
Sponsor class: OTHER
First posted: 2006-01-06
Enrollment: 16
Sex: ALL
Minimum age (years): 16
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: To determine whether the use of two antiviral agents in combination will be better than placebo in the treatment of an inflammatory sidease of the spinal cord caused by HTLV-I

Detailed description: Randomised, double-blind, placebo-controlled two centre study of zidvoudine plus lamivudine in HAM/TSP 24 patients randomised 1:1 2-4 week lead-in 6 months randomised phase followed by 6 months open-label therapy with active drug Primary endpoint: clinical Secondary endpoints: virological and immunological

Eligibility criteria: Inclusion Criteria:

* HTLV-I-associated myelopathy

Exclusion Criteria:

* prior exposure to zidovudine or lamivudine on disease modifying therapy
* under age 16

Primary outcomes:
measure: Timed walk
timeFrame: 6 months
measure: Osame's Motor Disability Score
timeFrame: 6 months
measure: Pain score
timeFrame: 6 months
measure: Urinary frequency
timeFrame: 6 months
measure: HTLV-1 proviral load
timeFrame: 6 months
Secondary outcomes:
measure: CD25%
timeFrame: 6 months
measure: HLA-DR%
timeFrame: 6 months
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Imperial College
Study officials:
affiliation: Imperial College London
name: Graham P Taylor, FRCP
role: PRINCIPAL_INVESTIGATOR
References:
citation: Taylor GP et al The Bridge Study - A double-blind, placebo controlled trial of zidovudine plus lamivudine for the treatment of patients with HTLV-I-associated myelopathy AIDS Research and Human Retroviruses 2003;19 (suppl 1) #O23
citation: Taylor GP, Goon P, Furukawa Y, Green H, Barfield A, Mosley A, Nose H, Babiker A, Rudge P, Usuku K, Osame M, Bangham CR, Weber JN. Zidovudine plus lamivudine in Human T-Lymphotropic Virus type-I-associated myelopathy: a randomised trial. Retrovirology. 2006 Sep 19;3:63. doi: 10.1186/1742-4690-3-63.
Clinical trial NCT01716780: Pain: Screen and Treat
Official title: Towards a Pain Free Hospital: Effect and Cost Effectiveness of Routine Screening and Treatment for Pain in Head and Neck Oncology Outpatients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Head and Neck Cancer
Pain
Lead sponsor: Royal Marsden NHS Foundation Trust
Sponsor class: OTHER
Collaborators: name: National Institute for Health Research, United Kingdom
First posted: 2012-10-30
Enrollment: 156
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study is looking at treating cancer pain in head and neck cancer. Patients are asked in outpatients to score their worst pain on a scale of 0 to 10 in the last 24 hours. Those with a pain score of 4 and above are randomised into the study.

Patients are allocated to continue with their current care (control group) or to be reviewed by the pain/palliative care team (intervention group). At baseline questionnaires are completed on level of pain, type of pain, quality of life and anxiety/depression. Information is also collected on the analgesia they've used in the past month and basic health economics (GP/hospital visits related to pain management and treatment).

Follow up in the trial is for 3 months and consists of questionnaires as above and further collection of information on analgesic usage and health economics.


Eligibility criteria: Inclusion Criteria:

* Patients attending head and neck oncology clinics
* Patients with a cancer diagnosis who are receiving anti cancer treatment or who have received anti cancer treatment
* Patients who score 4 or more on the Brief Pain Inventory numerical rating scale screening question 'worst pain in past 24 hours'

Exclusion Criteria:

* age below 18 years
* patients unable to respond to an English written assessment
* patients with medical conditions that could affect their mental function or level of consciousness such as stroke, or dementia
* patients who score \<4 on the Brief Pain Inventory numerical rating scale screening question
* patients already under the care of a pain/palliative care service

Primary outcomes:
measure: The change in pain score summarized from patient reports
timeFrame: 1 month, 2 months and 3 months
Secondary outcomes:
measure: Impact of pain
timeFrame: 1 month, 2 months, 3 months
measure: Adequacy of pain treatment
timeFrame: 1 month, 2 months and 3 months
measure: Quality of life
timeFrame: 1 month, 2 months and 3 months
measure: Patient satisfaction
timeFrame: 1 month, 2 months and 3 months
measure: Anxiety and depression
timeFrame: 1 month, 2 months and 3 months
measure: Treatment costs
timeFrame: 1 month, 2 months and 3 months
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Royal Marsden Hospital
Study officials:
affiliation: Royal Marsden NHS Foundation Trust
name: John E Williams
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02162680: An Evaluation of the Effectiveness of Local Anesthetics Used During Intravenous Catheter Insertion
Official title: An Evaluation of the Effectiveness of Local Anesthetics Used During Intravenous Catheter Insertion
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: IV Insertion Pain
Keywords: local anesthesia
intravenous catheter
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2014-06-13
Enrollment: 99
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare how well different anesthetic, or numbing, solutions injected under the skin work in reducing the discomfort associated with placing a catheter in a vein. Two different medications, lidocaine and normal saline with benzyl alcohol, have been found to be effective in reducing discomfort when injected under the skin just prior to inserting the catheter. This study compares these two solutions, and will compare the discomfort that occurs both with and without using these solutions.


Eligibility criteria: Inclusion Criteria:

* adult patients (aged 18 or older)
* admitted to a general medical or surgical unit at Durham Regional Hospital (DRH)
* have a physician's order for an IV
* are able to speak, read and understand English
* referred to the Vascular Access Specialty Team (VAST) at DRH for IV catheterization

Exclusion Criteria:

* admission to the emergency room, pre-op unit, an outpatient unit, a psychiatric unit, an intensive care unit, a pre- or postnatal care unit, or labor and delivery units;
* history of a psychological disorder, as determined from the patient's chart;
* history of peripheral neuropathy, as determined by patient's chart;
* history of IV drug abuse, as determined from the patient's chart;
* decreased sensation in the arm or hands, as reported in the chart or by the patient;
* patient disorientation or confusion (i.e., unable to state person, place, time or unable to comprehend instructions for completing Visual Analog Scale);
* a known allergy to lidocaine or benzyl alcohol as determined from the patient's chart;
* veins that cannot be palpated and are difficult to visualize by VAST nurses;
* pregnancy;
* an order for the emergency insertion of an IV by the patient's doctor or assigned nurse;
* an IV insertion that requires the use of a catheter gauged 18 or larger
* severe vision impairment, as determined by the patient's inability to read the Visual Analogue Scale

Primary outcomes:
measure: Differences in Patients' Perceptions of Pain Between Treatment Methods
timeFrame: at pre injection, during anesthetic injection, and during catheter insertion, up to approximately 1 minute
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Duke Health
name: Julia Aucoin, DNS, RN
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03344380: Identification of Genetic Polymorphism Related to Acute Kidney Injury After Liver Transplantation Through Genome-wide Association Study (GWAS) in Korean Population
Official title: Identification of Genetic Polymorphism Related to Acute Kidney Injury After Liver Transplantation Through Genome-wide Association Study (GWAS) in Korean Population
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: The Recipients Undergoing Liver Transplantation
Keywords: Gene polymorphism
acute kidney injury
liver transplantation
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2017-11-17
Enrollment: 330
Sex: ALL
Minimum age (years): 19
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients scheduled for liver transplantation

Brief summary: Some of the liver transplantation recipients experience postoperative acute kidney injury due to various causes including genetic factors. Prevention of postoperative acute kidney injury is essential for postoperative care in liver transplantation recipients. The aim of this study is to investigate the relationship between gene polymorphisms and the occurrence of acute kidney injury after liver transplantation by performing genome-wide association study (GWAS).


Eligibility criteria: Inclusion Criteria:

1) adult patients scheduled for liver transplantation

Exclusion Criteria:

1. Patients on dialysis
2. patients not able to read, or understand the consent form
3. ethnicity, other than asian
4. patients refusal

Primary outcomes:
measure: Acute kidney injury after liver transplantation
timeFrame: Participants will be followed up during the first 72 hours post-liver transplantation in order to confirm the development of acute kidney injury.
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Study officials:
References:
Clinical trial NCT04238780: Erector Spinae Plane Block Reduces Postoperative Pain Following Laparoscopic Colorectal Operation
Official title: Ultrasound Guided Erector Spinae Plane Block Reduces Postoperative Pain Following Laparoscopic Colorectal Operation: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Postoperative Pain
Lead sponsor: Gachon University Gil Medical Center
Sponsor class: OTHER
First posted: 2020-01-23
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this study is to evaluate the effect of ultrasound guided erector spinae plane block on postoperative pain and quality of recovery after laparoscopic colon surgery.

Detailed description: .The goal of this study is to evaluate the effect of ultrasound guided erector spinae plane block on postoperative pain and quality of recovery after laparoscopic colon surgery.

Eligibility criteria: Inclusion Criteria:

* aged between 20 and 70 years, with an American Society of Anesthesiologists physical status of 1 or 2, who were scheduled for laparoscopic colorectal operation

Exclusion Criteria:

* sensitivity to local anesthetic, bleeding disorders , receiving anticoagulant, body mass index (BMI) over 35/kg/m2 spine or chest wall deformity pregnancy tolerance to opioid analgesics inability to use patient-controlled analgesia (PCA)

Primary outcomes:
measure: numerical rating scale on rest and cough
timeFrame: 24 hours after surgery
Secondary outcomes:
measure: opioid consumption
timeFrame: 24 hours after surgery
measure: Quality of Recovery
timeFrame: 1day before operation, post op 24 hours
measure: need for analgesics
timeFrame: 24 hours after surgery
Other outcomes:
Locations:
city: Incheon
country: Korea, Republic of
facility: Gachon University College of Medicine, Gil Hospital
Study officials:
affiliation: Gachon University Gil Medical Center
name: hyunjeong kwack, md,phd
role: STUDY_DIRECTOR
References:
Clinical trial NCT00995280: Single Lumen Needle Without Flushing or Double Lumen Needle With Follicle Flushing in Oocyte Retrieval
Official title: Single Lumen Needle Without Flushing or Double Lumen Needle With Follicle Flushing in Oocyte Retrieval
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Oocyte Retrieval
Keywords: follicle flushing
oocyte retrieval
needle
Lead sponsor: Baskent University
Sponsor class: OTHER
First posted: 2009-10-15
Enrollment: 400
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 41
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: The aim of this study is to compare whether oocyte flushing during retrieval is effective or not.

Detailed description: In total 300 patients will be randomized for the effectiveness of single or double lumen needle during oocyte retrieval. Double lumen needles give an opportunity of washing to the follicle with flush. Single lumen needles seem to be faster and no need for flushing. We aim to compare to the differences of the use of both needles.

Eligibility criteria: Inclusion Criteria:

* Patients undergoing IVF/ICSI cycles.

Exclusion Criteria:

* Poor responder patients who have lower than 6 follicles at hCG administration day.
* Patients having over 30 follicles.

Primary outcomes:
measure: Metaphase 2 oocyte number
timeFrame: 6months
Secondary outcomes:
measure: clinical pregnancy rate
timeFrame: 6 months
Other outcomes:
Locations:
city: Adana
country: Turkey
facility: Baskent University
Study officials:
References:
Clinical trial NCT00587080: Stapled TransAnal Rectal Resection (STARR): Clinical and Radiological Outcome
Official title: Stapled TransAnal Rectal Resection (STARR): Correlation Between Clinical and Radiological Outcome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obstructed Defecation Syndrome (ODS)
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2008-01-07
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Study population: Patients with ODS and diagnosis of rectal redundancy (intussusception/rectoceles) in MR defecography

Brief summary: To evaluate the correlation between clinical and radiological outcome after Stapled TransAnal Rectal Resection (STARR)


Eligibility criteria: Inclusion Criteria:

* \> 18 years
* clinical signs of ODS with prior not effective conservative treatment
* anterior rectoceles and/or intussusceptions in MR-defecography

Exclusion Criteria:

* \< 18 years
* fixed enteroceles
* severe fecal incontinence
* external rectal prolapse
* anismus

Primary outcomes:
measure: Clinical and radiological outcome as assessed by closed-configuration MR defecography
Secondary outcomes:
measure: Morbidity and Mortality after STARR
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: University Hospital, Clinic for Visceral and Transplantation Surgery
Study officials:
affiliation: University of Zurich
name: Daniel Dindo, MD
role: PRINCIPAL_INVESTIGATOR
References: