Clinical trial NCT01000727: The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial
Official title: A Clinical Outcomes Study of Darapladib Versus Placebo in Subjects Following Acute Coronary Syndrome to Compare the Incidence of Major Adverse Cardiovascular Events (MACE).
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Acute Coronary Syndrome
Keywords: Atherosclerosis
Heart disease
Cardiovascular disease
Lp-PLA2 inhibitor
The TIMI Study Group
Coronary Heart Disease (CHD)
Acute Coronary Syndrome (ACS)
Lead sponsor: GlaxoSmithKline
Sponsor class: INDUSTRY
Collaborators: name: The TIMI Study Group
First posted: 2009-10-23
Enrollment: 13026
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will test whether darapladib can safely lower the chances of having a cardiovascular event (such as a heart attack or urgent coronary revascularization (e.g. medical procedures performed to restore the normal blood flow in patients with atherosclerosis)) when treatment is started within 30 days after an acute coronary syndrome (also called ACS).

Detailed description: Subjects who qualify for the study will be randomized 1:1 to either darapladib or placebo administered in addition to standard therapy. Following the baseline visit, subjects will be expected to return for clinic visits at 1 month, 3 months, 6 months and every 6 months until the end of the study.

Eligibility criteria: Inclusion Criteria:

* Signed written informed consent.
* Men or women at least 18 years old (in Taiwan, at least 20 years old). Women must be post-menopausal or using a highly effective method for avoidance of pregnancy.
* Hospitalization for acute coronary syndrome (ACS) within 30 days prior to study entry.
* Clinically stable for 24 hours prior to study entry.
* A planned percutaneous coronary intervention (PCI) should be performed prior to study entry, whenever possible.
* At least one of the following:
* At least 60 years old.
* Myocardial infarction prior to the qualifying ACS event.
* Diabetes mellitus requiring treatment with medication.
* Diagnosed mild or moderate reduction in kidney function.
* Cerebrovascular disease (carotid artery disease or ischemic stroke more than 3 months prior to study entry) OR peripheral artery disease.

Exclusion Criteria:

* ACS symptoms or lab results not believed to be caused by a narrowing or blocked coronary artery.
* No major coronary artery with a blockage of more than 50% (unless all stenoses are successfully treated by PCI).
* Planned coronary artery bypass graft (CABG) surgery, or CABG surgery performed after the qualifying ACS event and prior to study entry.
* Certain types of liver disease.
* Severe reduction in kidney function OR removal of a kidney OR kidney transplant.
* Severe heart failure.
* Blood pressure higher than normal despite lifestyle changes and treatment with medications.
* Any life-threatening disease with a life expectancy of less than 2 years (other than heart disease) that may prevent the subject from completing the study.
* Severe asthma that is poorly controlled with medication.
* Pregnancy (Note: A pregnancy test will be performed on all non-sterile women prior to study entry).
* Previous severe allergic reaction to food, medications, drink, insect stings, etc.
* Drug or alcohol abuse within the past 6 months. Mental/psychological impairment that may prevent the subject from complying with study procedures or understanding the goal and potential risks of participating in the study.
* Certain medications that may interfere with the study medication (these will be identified by the study doctor).
* If both birth parents are at least 50% Japanese, Chinese, or Korean ancestry, must have a blood sample collected for Lp-PLA2 activity. Those with Lp-PLA2 activity less than or equal to 20.0 nmol/min/mL are excluded.
* Previously took darapladib (SB-480848).
* Participation in a study of an investigational medication within the past 30 days.
* Current participation in a study of an investigational device.
* Any other reason the investigator deems the subject should not participate in the study.

Primary outcomes:
measure: Number of Participants With First Occurrence of Any Event in the Composite of Major Coronary Events During the Time Period for Follow-up (FU) of Cardiovascular (CV) Event
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
Secondary outcomes:
measure: Number of Participants With First Occurrence of Any Component of the Composite of Major Adverse Cardiovascular Events (Cardiovascular [CV] Death, Non-fatal MI or Non-fatal Stroke) During the Time Period for Follow-up of CV Events
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
measure: Number of Participants With Cardiovascular Death During the Time Period for Follow-up of Cardiovascular Events
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
measure: Number of Participants With First Occurrence of MI (Fatal/Nonfatal) During the Time Period for Follow-up of Cardiovascular Events
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
measure: Number of Participants With First Occurrence of Stroke (Fatal/Non-fatal) During the Time Period for Follow-up of Cardiovascular Events
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
measure: Number of Participants With CHD Death During the Time Period for Follow-up of Cardiovascular Events
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
measure: Number of Participants With Urgent Coronary Revascularization for Myocardial Ischemia During the Time Period for Follow-up of Cardiovascular Events
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
measure: Number of Participants With First Occurrence of Any Event in the Composite of Total Coronary Events (CHD Death, Non-fatal MI, Hospitalization for Unstable Angina, or Any Coronary Revascularization Procedure) During the Time Period for FU of CV Events
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
measure: Number of Participants With First Occurrence of Any Coronary Revascularization Procedures (Excluding Coronary Revascularization Planned Prior to Randomization, But Performed After Randomization) During the Time Period for Follow-up of Cardiovascular Event
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
measure: Number of Participants With First Occurrence of Any Component of the Composite of All-cause Mortality, Non-fatal MI, or Nonfatal Stroke During the Time Period for Follow-up of Cardiovascular Events
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
measure: Number of Participants With First Occurrence of Any Event in the Composite of CHD Death and Non-fatal MI During the Time Period for Follow-up of Cardiovascular Events
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
measure: Number of Participants With All-cause Mortality During the Time Period for Vital Status
timeFrame: From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
Other outcomes:
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facility: GSK Investigational Site
state: Pennsylvania
city: York
country: United States
facility: GSK Investigational Site
state: Pennsylvania
city: Charleston
country: United States
facility: GSK Investigational Site
state: South Carolina
city: Charleston
country: United States
facility: GSK Investigational Site
state: South Carolina
city: Columbia
country: United States
facility: GSK Investigational Site
state: South Carolina
city: Greenville
country: United States
facility: GSK Investigational Site
state: South Carolina
city: Rapid City
country: United States
facility: GSK Investigational Site
state: South Dakota
city: Chattanooga
country: United States
facility: GSK Investigational Site
state: Tennessee
city: Columbia
country: United States
facility: GSK Investigational Site
state: Tennessee
city: Jackson
country: United States
facility: GSK Investigational Site
state: Tennessee
city: Jackson
country: United States
facility: GSK Investigational Site
state: Tennessee
city: Johnson City
country: United States
facility: GSK Investigational Site
state: Tennessee
city: Nashville
country: United States
facility: GSK Investigational Site
state: Tennessee
city: Oak Ridge
country: United States
facility: GSK Investigational Site
state: Tennessee
city: Amarillo
country: United States
facility: GSK Investigational Site
state: Texas
city: Austin
country: United States
facility: GSK Investigational Site
state: Texas
city: Corpus Christi
country: United States
facility: GSK Investigational Site
state: Texas
city: Dallas
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facility: GSK Investigational Site
state: Texas
city: Dallas
country: United States
facility: GSK Investigational Site
state: Texas
city: Fort Worth
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facility: GSK Investigational Site
state: Texas
city: Galveston
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facility: GSK Investigational Site
state: Texas
city: Harker Heights
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facility: GSK Investigational Site
state: Texas
city: Houston
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facility: GSK Investigational Site
state: Texas
city: Houston
country: United States
facility: GSK Investigational Site
state: Texas
city: Houston
country: United States
facility: GSK Investigational Site
state: Texas
city: Houston
country: United States
facility: GSK Investigational Site
state: Texas
city: Katy
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facility: GSK Investigational Site
state: Texas
city: Kingwood
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facility: GSK Investigational Site
state: Texas
city: Round Rock
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facility: GSK Investigational Site
state: Texas
city: San Antonio
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facility: GSK Investigational Site
state: Texas
city: San Marcos
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facility: GSK Investigational Site
state: Texas
city: Sugar Land
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facility: GSK Investigational Site
state: Texas
city: Tyler
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facility: GSK Investigational Site
state: Texas
city: Victoria
country: United States
facility: GSK Investigational Site
state: Texas
city: Lynchburg
country: United States
facility: GSK Investigational Site
state: Virginia
city: Midlothian
country: United States
facility: GSK Investigational Site
state: Virginia
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country: United States
facility: GSK Investigational Site
state: Virginia
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country: United States
facility: GSK Investigational Site
state: Virginia
city: Richmond
country: United States
facility: GSK Investigational Site
state: Virginia
city: Winchester
country: United States
facility: GSK Investigational Site
state: Virginia
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
state: Wisconsin
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country: United States
facility: GSK Investigational Site
state: Wisconsin
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country: United States
facility: GSK Investigational Site
state: Wisconsin
city: Wausau
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facility: GSK Investigational Site
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facility: GSK Investigational Site
state: Buenos Aires
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
state: Córdova
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facility: GSK Investigational Site
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facility: GSK Investigational Site
state: Santa Fe
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
city: Corrientes
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facility: GSK Investigational Site
city: Haedo, Buenos Aires
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facility: GSK Investigational Site
city: San Miguel de Tucuman
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facility: GSK Investigational Site
city: Santa fe
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facility: GSK Investigational Site
city: Sante Fe
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facility: GSK Investigational Site
city: Sante Fe
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facility: GSK Investigational Site
city: Tucuman
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facility: GSK Investigational Site
city: Zárate
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facility: GSK Investigational Site
city: Garran
country: Australia
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facility: GSK Investigational Site
state: New South Wales
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facility: GSK Investigational Site
state: New South Wales
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
state: South Australia
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facility: GSK Investigational Site
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facility: GSK Investigational Site
state: Tasmania
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
city: Aalst
country: Belgium
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
city: Bruxelles
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facility: GSK Investigational Site
city: Edegem
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facility: GSK Investigational Site
city: Genk
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facility: GSK Investigational Site
city: La Louvière
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facility: GSK Investigational Site
city: Leuven
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facility: GSK Investigational Site
city: Liège
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facility: GSK Investigational Site
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facility: GSK Investigational Site
city: Salvador
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
state: Rio Grande Du Norte
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facility: GSK Investigational Site
state: São Paulo
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facility: GSK Investigational Site
state: São Paulo
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facility: GSK Investigational Site
state: São Paulo
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facility: GSK Investigational Site
state: São Paulo
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facility: GSK Investigational Site
state: São Paulo
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facility: GSK Investigational Site
city: Brasília
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facility: GSK Investigational Site
city: Campinas
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facility: GSK Investigational Site
city: Campo Grande
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facility: GSK Investigational Site
city: Rio de Janeiro
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facility: GSK Investigational Site
city: Rio De Janeiro
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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city: São Paulo
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facility: GSK Investigational Site
city: São Paulo
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facility: GSK Investigational Site
city: Uberlandia
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facility: GSK Investigational Site
city: Dimitrovgrad
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city: Haskovo
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facility: GSK Investigational Site
city: Pleven
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facility: GSK Investigational Site
city: Plovdiv
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city: Plovdiv
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facility: GSK Investigational Site
city: Sofia
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facility: GSK Investigational Site
city: Sofia
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facility: GSK Investigational Site
city: Sofia
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facility: GSK Investigational Site
city: Sofia
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facility: GSK Investigational Site
city: Sofia
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facility: GSK Investigational Site
city: Sofia
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facility: GSK Investigational Site
city: Veliko Tarnovo
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facility: GSK Investigational Site
city: Edmonton
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facility: GSK Investigational Site
state: Alberta
city: Campbell River
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facility: GSK Investigational Site
state: British Columbia
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facility: GSK Investigational Site
state: British Columbia
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facility: GSK Investigational Site
state: British Columbia
city: Vancouver
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facility: GSK Investigational Site
state: British Columbia
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facility: GSK Investigational Site
state: British Columbia
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facility: GSK Investigational Site
state: Newfoundland and Labrador
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facility: GSK Investigational Site
state: Nova Scotia
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facility: GSK Investigational Site
state: Ontario
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
state: Ontario
city: Kelowna
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facility: GSK Investigational Site
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city: Mississauga
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facility: GSK Investigational Site
state: Ontario
city: Newmarket
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facility: GSK Investigational Site
state: Ontario
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facility: GSK Investigational Site
state: Ontario
city: Oshawa
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facility: GSK Investigational Site
state: Ontario
city: Ottawa
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facility: GSK Investigational Site
state: Ontario
city: Sarnia
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facility: GSK Investigational Site
state: Ontario
city: Sudbury
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facility: GSK Investigational Site
state: Ontario
city: Sudbury
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facility: GSK Investigational Site
state: Ontario
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facility: GSK Investigational Site
state: Ontario
city: Toronto
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facility: GSK Investigational Site
state: Ontario
city: Toronto
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facility: GSK Investigational Site
state: Ontario
city: Greenfield Park
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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city: Thetford Mines
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facility: GSK Investigational Site
state: Quebec
city: Temuco
country: Chile
facility: GSK Investigational Site
state: Región De La Araucania
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facility: GSK Investigational Site
state: Región Del Biobio
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facility: GSK Investigational Site
state: Región Del Biobio
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facility: GSK Investigational Site
state: Región Metro De Santiago
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facility: GSK Investigational Site
state: Región Metro De Santiago
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facility: GSK Investigational Site
state: Región Metro De Santiago
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facility: GSK Investigational Site
state: Valparaíso
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facility: GSK Investigational Site
city: Santiago
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facility: GSK Investigational Site
city: Temuco
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facility: GSK Investigational Site
city: Lanzhou
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facility: GSK Investigational Site
state: Gansu
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facility: GSK Investigational Site
state: Guangdong
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facility: GSK Investigational Site
state: Guangdong
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facility: GSK Investigational Site
state: Guangxi
city: Haikou
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facility: GSK Investigational Site
state: Hainan
city: Shijiazhuang
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facility: GSK Investigational Site
state: Hebei
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facility: GSK Investigational Site
state: Jiangsu
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facility: GSK Investigational Site
state: Liaoning
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facility: GSK Investigational Site
state: Liaoning
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facility: GSK Investigational Site
state: Liaoning
city: Xian
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facility: GSK Investigational Site
state: Shaanxi
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facility: GSK Investigational Site
state: Shandong
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facility: GSK Investigational Site
state: Sichuan
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facility: GSK Investigational Site
state: Zhejiang
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facility: GSK Investigational Site
city: Beijing
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facility: GSK Investigational Site
city: Beijing
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facility: GSK Investigational Site
city: Beijing
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facility: GSK Investigational Site
city: Beijing
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facility: GSK Investigational Site
city: Beijing
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facility: GSK Investigational Site
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facility: GSK Investigational Site
city: Jinan
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facility: GSK Investigational Site
city: Shanghai
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facility: GSK Investigational Site
city: Shanghai
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facility: GSK Investigational Site
city: Shanghai
country: China
facility: GSK Investigational Site
city: Suzhou
country: China
facility: GSK Investigational Site
city: Armenia
country: Colombia
facility: GSK Investigational Site
city: Barranquilla
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facility: GSK Investigational Site
city: Bogota
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facility: GSK Investigational Site
city: Bogota
country: Colombia
facility: GSK Investigational Site
city: Bogota
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facility: GSK Investigational Site
city: Bogotá
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facility: GSK Investigational Site
city: Bucaramanga
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facility: GSK Investigational Site
city: Cartagena
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facility: GSK Investigational Site
city: Manizales
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facility: GSK Investigational Site
city: Medellin
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facility: GSK Investigational Site
city: Medellín
country: Colombia
facility: GSK Investigational Site
city: Brno
country: Czechia
facility: GSK Investigational Site
city: Brno
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facility: GSK Investigational Site
city: Caslav
country: Czechia
facility: GSK Investigational Site
city: Jihlava
country: Czechia
facility: GSK Investigational Site
city: Kromeriz
country: Czechia
facility: GSK Investigational Site
city: Milevsko
country: Czechia
facility: GSK Investigational Site
city: Olomouc
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facility: GSK Investigational Site
city: Plzen - Bory
country: Czechia
facility: GSK Investigational Site
city: Praha 10
country: Czechia
facility: GSK Investigational Site
city: Praha 2
country: Czechia
facility: GSK Investigational Site
city: Slany
country: Czechia
facility: GSK Investigational Site
city: Svitavy
country: Czechia
facility: GSK Investigational Site
city: Usti nad Orlici
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facility: GSK Investigational Site
city: Zlin
country: Czechia
facility: GSK Investigational Site
city: Aalborg
country: Denmark
facility: GSK Investigational Site
city: Aarhus
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facility: GSK Investigational Site
city: Esbjerg
country: Denmark
facility: GSK Investigational Site
city: Frederikssund
country: Denmark
facility: GSK Investigational Site
city: Glostrup
country: Denmark
facility: GSK Investigational Site
city: Hellerup
country: Denmark
facility: GSK Investigational Site
city: Herlev
country: Denmark
facility: GSK Investigational Site
city: Holbæk
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facility: GSK Investigational Site
city: Hvidovre
country: Denmark
facility: GSK Investigational Site
city: Koebenhavn N
country: Denmark
facility: GSK Investigational Site
city: Kolding
country: Denmark
facility: GSK Investigational Site
city: København NV
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facility: GSK Investigational Site
city: København S
country: Denmark
facility: GSK Investigational Site
city: Køge
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facility: GSK Investigational Site
city: Næstved
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facility: GSK Investigational Site
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facility: GSK Investigational Site
city: Silkeborg
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facility: GSK Investigational Site
city: Svendborg
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facility: GSK Investigational Site
city: Pau
country: France
facility: GSK Investigational Site
state: Aquitaine
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facility: GSK Investigational Site
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facility: GSK Investigational Site
state: Nord-Pas-de-Calais
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country: France
facility: GSK Investigational Site
city: Besançon Cedex
country: France
facility: GSK Investigational Site
city: Bron
country: France
facility: GSK Investigational Site
city: Créteil
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facility: GSK Investigational Site
city: Dijon Cedex
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facility: GSK Investigational Site
city: Lagny sur Marne
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facility: GSK Investigational Site
city: Le Plessis Robinson
country: France
facility: GSK Investigational Site
city: Lille
country: France
facility: GSK Investigational Site
city: Marseille Cedex 08
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facility: GSK Investigational Site
city: Montfermeil
country: France
facility: GSK Investigational Site
city: Paris Cedex 18
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facility: GSK Investigational Site
city: Paris
country: France
facility: GSK Investigational Site
city: Poitiers
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facility: GSK Investigational Site
city: Quincy sous Sénart
country: France
facility: GSK Investigational Site
city: Rennes
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facility: GSK Investigational Site
city: Strasbourg Cedex
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facility: GSK Investigational Site
city: Toulouse
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facility: GSK Investigational Site
city: Tourcoing
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facility: GSK Investigational Site
city: Valenciennes
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facility: GSK Investigational Site
city: Bad Krozingen
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facility: GSK Investigational Site
state: Baden-Wuerttemberg
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facility: GSK Investigational Site
state: Baden-Wuerttemberg
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facility: GSK Investigational Site
state: Baden-Wuerttemberg
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facility: GSK Investigational Site
state: Baden-Wuerttemberg
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facility: GSK Investigational Site
state: Baden-Wuerttemberg
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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city: Langen
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facility: GSK Investigational Site
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city: Limburg
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facility: GSK Investigational Site
state: Hessen
city: Bad Rothenfelde
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facility: GSK Investigational Site
state: Niedersachsen
city: Hannover
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facility: GSK Investigational Site
state: Niedersachsen
city: Oldenburg
country: Germany
facility: GSK Investigational Site
state: Niedersachsen
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facility: GSK Investigational Site
state: Nordrhein-Westfalen
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facility: GSK Investigational Site
state: Nordrhein-Westfalen
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
state: Nordrhein-Westfalen
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facility: GSK Investigational Site
state: Nordrhein-Westfalen
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facility: GSK Investigational Site
state: Rheinland-Pfalz
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facility: GSK Investigational Site
state: Saarland
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facility: GSK Investigational Site
state: Schleswig-Holstein
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facility: GSK Investigational Site
state: Schleswig-Holstein
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facility: GSK Investigational Site
state: Thueringen
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facility: GSK Investigational Site
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country: Germany
facility: GSK Investigational Site
city: Berlin
country: Germany
facility: GSK Investigational Site
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facility: GSK Investigational Site
city: Halle
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
city: Zalaegerszeg
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facility: GSK Investigational Site
city: Ahmedabad
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facility: GSK Investigational Site
city: Ahmedabad
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
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facility: GSK Investigational Site
city: Faridabad
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facility: GSK Investigational Site
city: Gandhinagar
country: India
facility: GSK Investigational Site
city: Gurgaon
country: India
facility: GSK Investigational Site
city: Hyderabad
country: India
facility: GSK Investigational Site
city: Hyderabad
country: India
facility: GSK Investigational Site
city: Hyderabad
country: India
facility: GSK Investigational Site
city: Hyderabad
country: India
facility: GSK Investigational Site
city: Hyderabad
country: India
facility: GSK Investigational Site
city: Indore
country: India
facility: GSK Investigational Site
city: Jaipur
country: India
facility: GSK Investigational Site
city: Lucknow
country: India
facility: GSK Investigational Site
city: Mohali
country: India
facility: GSK Investigational Site
city: New Delhi
country: India
facility: GSK Investigational Site
city: New Delhi
country: India
facility: GSK Investigational Site
city: New Delhi
country: India
facility: GSK Investigational Site
city: Noida
country: India
facility: GSK Investigational Site
city: Patiala
country: India
facility: GSK Investigational Site
city: Pune,
country: India
facility: GSK Investigational Site
city: Pune
country: India
facility: GSK Investigational Site
city: Secunderabad,
country: India
facility: GSK Investigational Site
city: Vadodara
country: India
facility: GSK Investigational Site
city: Visakhapatnam
country: India
facility: GSK Investigational Site
city: Ashkelon
country: Israel
facility: GSK Investigational Site
city: Beer Sheva
country: Israel
facility: GSK Investigational Site
city: Haddera
country: Israel
facility: GSK Investigational Site
city: Haifa
country: Israel
facility: GSK Investigational Site
city: Haifa
country: Israel
facility: GSK Investigational Site
city: Haifa
country: Israel
facility: GSK Investigational Site
city: Holon
country: Israel
facility: GSK Investigational Site
city: Jerusalem
country: Israel
facility: GSK Investigational Site
city: Jerusalem
country: Israel
facility: GSK Investigational Site
city: Jerusalem
country: Israel
facility: GSK Investigational Site
city: Jerusalem
country: Israel
facility: GSK Investigational Site
city: Kfar Saba
country: Israel
facility: GSK Investigational Site
city: Nahariya
country: Israel
facility: GSK Investigational Site
city: Poriya
country: Israel
facility: GSK Investigational Site
city: Raanana
country: Israel
facility: GSK Investigational Site
city: Ramat-Gan
country: Israel
facility: GSK Investigational Site
city: Rehovot
country: Israel
facility: GSK Investigational Site
city: Safed
country: Israel
facility: GSK Investigational Site
city: Tel Aviv
country: Israel
facility: GSK Investigational Site
city: Catanzaro
country: Italy
facility: GSK Investigational Site
state: Calabria
city: Napoli
country: Italy
facility: GSK Investigational Site
state: Campania
city: Bologna
country: Italy
facility: GSK Investigational Site
state: Emilia-Romagna
city: Carpi
country: Italy
facility: GSK Investigational Site
state: Emilia-Romagna
city: Ferrara
country: Italy
facility: GSK Investigational Site
state: Emilia-Romagna
city: Parma
country: Italy
facility: GSK Investigational Site
state: Emilia-Romagna
city: Palmanova
country: Italy
facility: GSK Investigational Site
state: Friuli-Venezia-Giulia
city: San Daniele del Friuli
country: Italy
facility: GSK Investigational Site
state: Friuli-Venezia-Giulia
city: Udine
country: Italy
facility: GSK Investigational Site
state: Friuli-Venezia-Giulia
city: Roma
country: Italy
facility: GSK Investigational Site
state: Lazio
city: Roma
country: Italy
facility: GSK Investigational Site
state: Lazio
city: Roma
country: Italy
facility: GSK Investigational Site
state: Lazio
city: Bergamo
country: Italy
facility: GSK Investigational Site
state: Lombardia
city: Milano
country: Italy
facility: GSK Investigational Site
state: Lombardia
city: Rozzano (Mi)
country: Italy
facility: GSK Investigational Site
state: Lombardia
city: Ascoli Piceno
country: Italy
facility: GSK Investigational Site
state: Marche
city: Novara
country: Italy
facility: GSK Investigational Site
state: Piemonte
city: Sassari
country: Italy
facility: GSK Investigational Site
state: Sardegna
city: Pisa
country: Italy
facility: GSK Investigational Site
state: Toscana
city: Treviso
country: Italy
facility: GSK Investigational Site
state: Veneto
city: Legnano
country: Italy
facility: GSK Investigational Site
city: Sassuolo
country: Italy
facility: GSK Investigational Site
city: Chiba
country: Japan
facility: GSK Investigational Site
city: Fukuoka
country: Japan
facility: GSK Investigational Site
city: Fukuoka
country: Japan
facility: GSK Investigational Site
city: Fukuoka
country: Japan
facility: GSK Investigational Site
city: Hokkaido
country: Japan
facility: GSK Investigational Site
city: Hokkaido
country: Japan
facility: GSK Investigational Site
city: Hokkaido
country: Japan
facility: GSK Investigational Site
city: Hyogo
country: Japan
facility: GSK Investigational Site
city: Kanagawa
country: Japan
facility: GSK Investigational Site
city: Kanagawa
country: Japan
facility: GSK Investigational Site
city: Kanagawa
country: Japan
facility: GSK Investigational Site
city: Kyoto
country: Japan
facility: GSK Investigational Site
city: Nagasaki
country: Japan
facility: GSK Investigational Site
city: Oita
country: Japan
facility: GSK Investigational Site
city: Okayama
country: Japan
facility: GSK Investigational Site
city: Osaka
country: Japan
facility: GSK Investigational Site
city: Osaka
country: Japan
facility: GSK Investigational Site
city: Osaka
country: Japan
facility: GSK Investigational Site
city: Saga
country: Japan
facility: GSK Investigational Site
city: Shizuoka
country: Japan
facility: GSK Investigational Site
city: Tokyo
country: Japan
facility: GSK Investigational Site
city: Tokyo
country: Japan
facility: GSK Investigational Site
city: Tokyo
country: Japan
facility: GSK Investigational Site
city: Tokyo
country: Japan
facility: GSK Investigational Site
city: Dae-Gu
country: Korea, Republic of
facility: GSK Investigational Site
city: Daejeon
country: Korea, Republic of
facility: GSK Investigational Site
city: Gangnam-gu, Seoul
country: Korea, Republic of
facility: GSK Investigational Site
city: Gwangju
country: Korea, Republic of
facility: GSK Investigational Site
city: Kangwon-do
country: Korea, Republic of
facility: GSK Investigational Site
city: Pusan
country: Korea, Republic of
facility: GSK Investigational Site
city: Seoul
country: Korea, Republic of
facility: GSK Investigational Site
city: Seoul
country: Korea, Republic of
facility: GSK Investigational Site
city: Seoul
country: Korea, Republic of
facility: GSK Investigational Site
city: Seoul
country: Korea, Republic of
facility: GSK Investigational Site
city: 's-Hertogenbosch
country: Netherlands
facility: GSK Investigational Site
city: Amersfoort
country: Netherlands
facility: GSK Investigational Site
city: Amsterdam
country: Netherlands
facility: GSK Investigational Site
city: Amsterdam
country: Netherlands
facility: GSK Investigational Site
city: Amsterdam
country: Netherlands
facility: GSK Investigational Site
city: Apeldoorn
country: Netherlands
facility: GSK Investigational Site
city: Blaricum
country: Netherlands
facility: GSK Investigational Site
city: Den Haag
country: Netherlands
facility: GSK Investigational Site
city: Deventer
country: Netherlands
facility: GSK Investigational Site
city: Dirksland
country: Netherlands
facility: GSK Investigational Site
city: Doetinchem
country: Netherlands
facility: GSK Investigational Site
city: Drachten
country: Netherlands
facility: GSK Investigational Site
city: Eindhoven
country: Netherlands
facility: GSK Investigational Site
city: Gorinchem
country: Netherlands
facility: GSK Investigational Site
city: Gouda
country: Netherlands
facility: GSK Investigational Site
city: Groningen
country: Netherlands
facility: GSK Investigational Site
city: Hardenberg
country: Netherlands
facility: GSK Investigational Site
city: Harderwijk
country: Netherlands
facility: GSK Investigational Site
city: Heerenveen
country: Netherlands
facility: GSK Investigational Site
city: Heerlen
country: Netherlands
facility: GSK Investigational Site
city: Helmond
country: Netherlands
facility: GSK Investigational Site
city: Hilversum
country: Netherlands
facility: GSK Investigational Site
city: Hoofddorp
country: Netherlands
facility: GSK Investigational Site
city: Hoorn
country: Netherlands
facility: GSK Investigational Site
city: Nijmegen
country: Netherlands
facility: GSK Investigational Site
city: OSS
country: Netherlands
facility: GSK Investigational Site
city: Roermond
country: Netherlands
facility: GSK Investigational Site
city: Rotterdam
country: Netherlands
facility: GSK Investigational Site
city: Rotterdam
country: Netherlands
facility: GSK Investigational Site
city: Sittard-geleen
country: Netherlands
facility: GSK Investigational Site
city: Sneek
country: Netherlands
facility: GSK Investigational Site
city: Tiel
country: Netherlands
facility: GSK Investigational Site
city: Tilburg
country: Netherlands
facility: GSK Investigational Site
city: Veldhoven
country: Netherlands
facility: GSK Investigational Site
city: Venlo
country: Netherlands
facility: GSK Investigational Site
city: Zoetermeer
country: Netherlands
facility: GSK Investigational Site
city: Auckland
country: New Zealand
facility: GSK Investigational Site
city: Auckland
country: New Zealand
facility: GSK Investigational Site
city: Christchurch
country: New Zealand
facility: GSK Investigational Site
city: Dunedin
country: New Zealand
facility: GSK Investigational Site
city: Hamilton
country: New Zealand
facility: GSK Investigational Site
city: Lower Hutt
country: New Zealand
facility: GSK Investigational Site
city: New Plymouth
country: New Zealand
facility: GSK Investigational Site
city: Palmerston North
country: New Zealand
facility: GSK Investigational Site
city: Takapuna, Auckland
country: New Zealand
facility: GSK Investigational Site
city: Tauranga
country: New Zealand
facility: GSK Investigational Site
city: Whangarei
country: New Zealand
facility: GSK Investigational Site
city: Miraflores, Lima
country: Peru
facility: GSK Investigational Site
state: Lima
city: San Martin de Porres
country: Peru
facility: GSK Investigational Site
state: Lima
city: Callao
country: Peru
facility: GSK Investigational Site
city: Lima Cercado
country: Peru
facility: GSK Investigational Site
city: Lima
country: Peru
facility: GSK Investigational Site
city: Lima
country: Peru
facility: GSK Investigational Site
city: Lima
country: Peru
facility: GSK Investigational Site
city: Cebu City
country: Philippines
facility: GSK Investigational Site
city: Davao
country: Philippines
facility: GSK Investigational Site
city: Manila
country: Philippines
facility: GSK Investigational Site
city: Quezon City
country: Philippines
facility: GSK Investigational Site
city: Quezon City
country: Philippines
facility: GSK Investigational Site
city: Quezon City
country: Philippines
facility: GSK Investigational Site
city: Bialystok
country: Poland
facility: GSK Investigational Site
city: Bydgoszcz
country: Poland
facility: GSK Investigational Site
city: Bytom
country: Poland
facility: GSK Investigational Site
city: Chrzanow
country: Poland
facility: GSK Investigational Site
city: Gdansk
country: Poland
facility: GSK Investigational Site
city: Gdynia
country: Poland
facility: GSK Investigational Site
city: Gdynia
country: Poland
facility: GSK Investigational Site
city: Gdynia
country: Poland
facility: GSK Investigational Site
city: Inowroclaw
country: Poland
facility: GSK Investigational Site
city: Krakow
country: Poland
facility: GSK Investigational Site
city: Krakow
country: Poland
facility: GSK Investigational Site
city: Lodz
country: Poland
facility: GSK Investigational Site
city: Lubin
country: Poland
facility: GSK Investigational Site
city: Mielec
country: Poland
facility: GSK Investigational Site
city: Olawa
country: Poland
facility: GSK Investigational Site
city: Opole
country: Poland
facility: GSK Investigational Site
city: Radom
country: Poland
facility: GSK Investigational Site
city: Skierniewice
country: Poland
facility: GSK Investigational Site
city: Tarnow
country: Poland
facility: GSK Investigational Site
city: Torun
country: Poland
facility: GSK Investigational Site
city: Tychy
country: Poland
facility: GSK Investigational Site
city: Walbrzych
country: Poland
facility: GSK Investigational Site
city: Warsaw
country: Poland
facility: GSK Investigational Site
city: Warszawa
country: Poland
facility: GSK Investigational Site
city: Warszawa
country: Poland
facility: GSK Investigational Site
city: Warszawa
country: Poland
facility: GSK Investigational Site
city: Wloclawek
country: Poland
facility: GSK Investigational Site
city: Wroclaw
country: Poland
facility: GSK Investigational Site
city: Wroclaw
country: Poland
facility: GSK Investigational Site
city: Wroclaw
country: Poland
facility: GSK Investigational Site
city: Zamosc
country: Poland
facility: GSK Investigational Site
city: Zielona Gora
country: Poland
facility: GSK Investigational Site
city: Baia Mare
country: Romania
facility: GSK Investigational Site
city: Braila
country: Romania
facility: GSK Investigational Site
city: Brasov
country: Romania
facility: GSK Investigational Site
city: Bucharest
country: Romania
facility: GSK Investigational Site
city: Bucharest
country: Romania
facility: GSK Investigational Site
city: Bucharest
country: Romania
facility: GSK Investigational Site
city: Bucharest
country: Romania
facility: GSK Investigational Site
city: Bucharest
country: Romania
facility: GSK Investigational Site
city: Bucharest
country: Romania
facility: GSK Investigational Site
city: Cluj-Napoca
country: Romania
facility: GSK Investigational Site
city: Constanta
country: Romania
facility: GSK Investigational Site
city: Craiova
country: Romania
facility: GSK Investigational Site
city: Iasi
country: Romania
facility: GSK Investigational Site
city: Targu Mures
country: Romania
facility: GSK Investigational Site
city: Barnaul
country: Russian Federation
facility: GSK Investigational Site
city: Ekaterinburg
country: Russian Federation
facility: GSK Investigational Site
city: Ekaterinburg
country: Russian Federation
facility: GSK Investigational Site
city: Gatchina
country: Russian Federation
facility: GSK Investigational Site
city: Kemerovo
country: Russian Federation
facility: GSK Investigational Site
city: Kemerovo
country: Russian Federation
facility: GSK Investigational Site
city: Krasnoyarsk
country: Russian Federation
facility: GSK Investigational Site
city: Moscow
country: Russian Federation
facility: GSK Investigational Site
city: Moscow
country: Russian Federation
facility: GSK Investigational Site
city: Moscow
country: Russian Federation
facility: GSK Investigational Site
city: Moscow
country: Russian Federation
facility: GSK Investigational Site
city: Moscow
country: Russian Federation
facility: GSK Investigational Site
city: Moscow
country: Russian Federation
facility: GSK Investigational Site
city: Moscow
country: Russian Federation
facility: GSK Investigational Site
city: Moscow
country: Russian Federation
facility: GSK Investigational Site
city: Moscow
country: Russian Federation
facility: GSK Investigational Site
city: Moscow
country: Russian Federation
facility: GSK Investigational Site
city: Nizhniy Novgorod
country: Russian Federation
facility: GSK Investigational Site
city: Nizhniy Novgorod
country: Russian Federation
facility: GSK Investigational Site
city: Novosibirsk
country: Russian Federation
facility: GSK Investigational Site
city: Novosibirsk
country: Russian Federation
facility: GSK Investigational Site
city: Orenburg
country: Russian Federation
facility: GSK Investigational Site
city: Samara
country: Russian Federation
facility: GSK Investigational Site
city: Saratov
country: Russian Federation
facility: GSK Investigational Site
city: Saratov
country: Russian Federation
facility: GSK Investigational Site
city: St'Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: St-Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: St-Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: St-Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: St. Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: St. Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: St. Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: St. Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: St. Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: St. Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: St. Petersburg
country: Russian Federation
facility: GSK Investigational Site
city: Tomsk
country: Russian Federation
facility: GSK Investigational Site
city: Tyumen
country: Russian Federation
facility: GSK Investigational Site
city: Tyumen
country: Russian Federation
facility: GSK Investigational Site
city: Yaroslavl
country: Russian Federation
facility: GSK Investigational Site
city: Bratislava
country: Slovakia
facility: GSK Investigational Site
city: Bratislava
country: Slovakia
facility: GSK Investigational Site
city: Bratislava
country: Slovakia
facility: GSK Investigational Site
city: Bratislava
country: Slovakia
facility: GSK Investigational Site
city: Kosice
country: Slovakia
facility: GSK Investigational Site
city: Nitra
country: Slovakia
facility: GSK Investigational Site
city: Nitra
country: Slovakia
facility: GSK Investigational Site
city: Nove Zamky
country: Slovakia
facility: GSK Investigational Site
city: Bloemfontein
country: South Africa
facility: GSK Investigational Site
state: Free State
city: Alberton
country: South Africa
facility: GSK Investigational Site
state: Gauteng
city: Johannesburg
country: South Africa
facility: GSK Investigational Site
state: Gauteng
city: Pretoria
country: South Africa
facility: GSK Investigational Site
state: Gauteng
city: Pretoria
country: South Africa
facility: GSK Investigational Site
state: Gauteng
city: Durban
country: South Africa
facility: GSK Investigational Site
state: KwaZulu- Natal
city: Durban
country: South Africa
facility: GSK Investigational Site
state: KwaZulu- Natal
city: Cape Town
country: South Africa
facility: GSK Investigational Site
state: Western Province
city: Cape Town
country: South Africa
facility: GSK Investigational Site
state: Western Province
city: Panorama
country: South Africa
facility: GSK Investigational Site
state: Western Province
city: Goodwood
country: South Africa
facility: GSK Investigational Site
city: Kempton Park
country: South Africa
facility: GSK Investigational Site
city: Paarl
country: South Africa
facility: GSK Investigational Site
city: Parktown West
country: South Africa
facility: GSK Investigational Site
city: Parow
country: South Africa
facility: GSK Investigational Site
city: Pretoria
country: South Africa
facility: GSK Investigational Site
city: Pretoria
country: South Africa
facility: GSK Investigational Site
city: Somerset West
country: South Africa
facility: GSK Investigational Site
city: Worcester
country: South Africa
facility: GSK Investigational Site
city: Alicante
country: Spain
facility: GSK Investigational Site
city: Barcelona
country: Spain
facility: GSK Investigational Site
city: Lerida
country: Spain
facility: GSK Investigational Site
city: León
country: Spain
facility: GSK Investigational Site
city: Madrid
country: Spain
facility: GSK Investigational Site
city: Madrid
country: Spain
facility: GSK Investigational Site
city: Malaga
country: Spain
facility: GSK Investigational Site
city: Oviedo
country: Spain
facility: GSK Investigational Site
city: San Juan/Alicante
country: Spain
facility: GSK Investigational Site
city: San Sebastián de los Reyes/Madrid
country: Spain
facility: GSK Investigational Site
city: San Sebastián
country: Spain
facility: GSK Investigational Site
city: Sevilla
country: Spain
facility: GSK Investigational Site
city: Valencia
country: Spain
facility: GSK Investigational Site
city: Vigo/Pontevedra
country: Spain
facility: GSK Investigational Site
city: Göteborg
country: Sweden
facility: GSK Investigational Site
city: Göteborg
country: Sweden
facility: GSK Investigational Site
city: Göteborg
country: Sweden
facility: GSK Investigational Site
city: Hässleholm
country: Sweden
facility: GSK Investigational Site
city: Jönköping
country: Sweden
facility: GSK Investigational Site
city: Stockholm
country: Sweden
facility: GSK Investigational Site
city: Västerås
country: Sweden
facility: GSK Investigational Site
city: Örebro
country: Sweden
facility: GSK Investigational Site
city: Östersund
country: Sweden
facility: GSK Investigational Site
city: Kaohsiung City
country: Taiwan
facility: GSK Investigational Site
city: Kaohsiung
country: Taiwan
facility: GSK Investigational Site
city: Taipei
country: Taiwan
facility: GSK Investigational Site
city: Taipei
country: Taiwan
facility: GSK Investigational Site
city: Taipei
country: Taiwan
facility: GSK Investigational Site
city: Yung Kang City
country: Taiwan
facility: GSK Investigational Site
city: Bangkoknoi
country: Thailand
facility: GSK Investigational Site
city: Bangkok
country: Thailand
facility: GSK Investigational Site
city: Chiangmai
country: Thailand
facility: GSK Investigational Site
city: Khon Kaen, Muang
country: Thailand
facility: GSK Investigational Site
city: Nakhon Ratchasima
country: Thailand
facility: GSK Investigational Site
city: Pathumthani
country: Thailand
facility: GSK Investigational Site
city: Ankara
country: Turkey
facility: GSK Investigational Site
city: Erzurum
country: Turkey
facility: GSK Investigational Site
city: Eskisehir
country: Turkey
facility: GSK Investigational Site
city: Izmir
country: Turkey
facility: GSK Investigational Site
city: Izmir
country: Turkey
facility: GSK Investigational Site
city: Izmir
country: Turkey
facility: GSK Investigational Site
city: Dnipropetrovsk
country: Ukraine
facility: GSK Investigational Site
city: Donetsk
country: Ukraine
facility: GSK Investigational Site
city: Kharkiv
country: Ukraine
facility: GSK Investigational Site
city: Kharkiv
country: Ukraine
facility: GSK Investigational Site
city: Kharkiv
country: Ukraine
facility: GSK Investigational Site
city: Kharkiv
country: Ukraine
facility: GSK Investigational Site
city: Kyiv
country: Ukraine
facility: GSK Investigational Site
city: Kyiv
country: Ukraine
facility: GSK Investigational Site
city: Kyiv
country: Ukraine
facility: GSK Investigational Site
city: Kyiv
country: Ukraine
facility: GSK Investigational Site
city: Kyiv
country: Ukraine
facility: GSK Investigational Site
city: Kyiv
country: Ukraine
facility: GSK Investigational Site
city: Lugansk
country: Ukraine
facility: GSK Investigational Site
city: Lutsk
country: Ukraine
facility: GSK Investigational Site
city: Mykolaiv
country: Ukraine
facility: GSK Investigational Site
city: Odesa
country: Ukraine
facility: GSK Investigational Site
city: Simferopol
country: Ukraine
facility: GSK Investigational Site
city: Vinnytsia
country: Ukraine
facility: GSK Investigational Site
city: Vinnytsia
country: Ukraine
facility: GSK Investigational Site
city: Zaporizhzhya
country: Ukraine
facility: GSK Investigational Site
city: Exeter
country: United Kingdom
facility: GSK Investigational Site
state: Devon
city: Torquay
country: United Kingdom
facility: GSK Investigational Site
state: Devon
city: Airdrie
country: United Kingdom
facility: GSK Investigational Site
state: Lanarkshire
city: Harrow
country: United Kingdom
facility: GSK Investigational Site
state: Middlesex
city: Northampton
country: United Kingdom
facility: GSK Investigational Site
state: Northamptonshire
city: Nottingham
country: United Kingdom
facility: GSK Investigational Site
state: Nottinghamshire
city: Chertsey
country: United Kingdom
facility: GSK Investigational Site
state: Surrey
city: Coventry
country: United Kingdom
facility: GSK Investigational Site
state: West Midlands
city: Antrim
country: United Kingdom
facility: GSK Investigational Site
city: Chichester
country: United Kingdom
facility: GSK Investigational Site
city: East Kilbride
country: United Kingdom
facility: GSK Investigational Site
city: Hertfordshire
country: United Kingdom
facility: GSK Investigational Site
city: Liverpool
country: United Kingdom
facility: GSK Investigational Site
city: Paisley
country: United Kingdom
facility: GSK Investigational Site
city: Stirling
country: United Kingdom
facility: GSK Investigational Site
Study officials:
affiliation: GlaxoSmithKline
name: GSK Clinical Trials
role: STUDY_DIRECTOR
References:
citation: Correa S, Morrow DA, Braunwald E, Davies RY, Goodrich EL, Murphy SA, Cannon CP, O'Donoghue ML. Cystatin C for Risk Stratification in Patients After an Acute Coronary Syndrome. J Am Heart Assoc. 2018 Oct 16;7(20):e009077. doi: 10.1161/JAHA.118.009077.
citation: Barger LK, Rajaratnam SMW, Cannon CP, Lukas MA, Im K, Goodrich EL, Czeisler CA, O'Donoghue ML. Short Sleep Duration, Obstructive Sleep Apnea, Shiftwork, and the Risk of Adverse Cardiovascular Events in Patients After an Acute Coronary Syndrome. J Am Heart Assoc. 2017 Oct 10;6(10):e006959. doi: 10.1161/JAHA.117.006959.
citation: Eisen A, Cannon CP, Braunwald E, Steen DL, Zhou J, Goodrich EL, Im K, Dalby AJ, Spinar J, Daga S, Lukas MA, O'Donoghue ML. Predictors of Nonuse of a High-Potency Statin After an Acute Coronary Syndrome: Insights From the Stabilization of Plaques Using Darapladib-Thrombolysis in Myocardial Infarction 52 (SOLID-TIMI 52) Trial. J Am Heart Assoc. 2017 Jan 11;6(1):e004332. doi: 10.1161/JAHA.116.004332.
citation: O'Donoghue ML, Braunwald E, White HD, Lukas MA, Tarka E, Steg PG, Hochman JS, Bode C, Maggioni AP, Im K, Shannon JB, Davies RY, Murphy SA, Crugnale SE, Wiviott SD, Bonaca MP, Watson DF, Weaver WD, Serruys PW, Cannon CP; SOLID-TIMI 52 Investigators; Steen DL. Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial. JAMA. 2014 Sep 10;312(10):1006-15. doi: 10.1001/jama.2014.11061.
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