louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00446212: Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
Official title: Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Anaesthesia
Keywords: anaesthesia
propofol
desflurane
dreaming
electroencephalography
Lead sponsor: Melbourne Health
Sponsor class: OTHER
First posted: 2007-03-12
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Detailed description: Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Eligibility criteria: Inclusion Criteria:

* Male and female patients
* Age between 18 and 50 years
* Presenting for elective surgery under general anaesthesia

Exclusion Criteria:

* Inadequate English language comprehension
* Major drug abuse problem

Primary outcomes:
measure: Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire
timeFrame: recovery room stay
Secondary outcomes:
Other outcomes:
Locations:
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Perth
country: Australia
facility: Royal Perth Hospital
state: Western Australia
city: Subiaco
country: Australia
facility: King Edward Memorial Hospital for Women
state: Western Australia
city: Hamilton
country: New Zealand
facility: Waikato Hospital
Study officials:
affiliation: Melbourne Health
name: Kate Leslie, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Liang Z, Wang Y, Ren Y, Li D, Voss L, Sleigh J, Li X. Detection of burst suppression patterns in EEG using recurrence rate. ScientificWorldJournal. 2014;2014:295070. doi: 10.1155/2014/295070. Epub 2014 Apr 17.
citation: Leslie K, Sleigh J, Paech MJ, Voss L, Lim CW, Sleigh C. Dreaming and electroencephalographic changes during anesthesia maintained with propofol or desflurane. Anesthesiology. 2009 Sep;111(3):547-55. doi: 10.1097/ALN.0b013e3181adf768.
Clinical trial NCT05959512: Smoking Pattern and Influencing Factors in Hospitalized Patients
Official title: A Survey of Smoking Patterns and Influencing Factors Among Hospitalized Patients
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Smoking Behaviors
Lead sponsor: Beijing Normal University
Sponsor class: OTHER
First posted: 2023-07-25
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population consists of hospitalized patients who smoke and meet the following inclusion and exclusion criteria. Inclusion criteria: (1) Aged 18 years or above; (2) Have a history of smoking, smoking ≥1 cigarette per day (3) Willing to participate in this study and sign an informed consent form. Exclusion criteria: (1) Have mental illness or cognitive impairment; (2) Unable to complete the questionnaire survey.

Brief summary: This study examines the smoking patterns and determinants of inpatients who smoke, develops tailored smoking cessation interventions based on their individual needs, and aims to enhance the effectiveness of quitting and lower the likelihood of relapse.

Detailed description: Smoking is a major risk factor for many chronic and acute diseases, and quitting smoking can bring significant health benefits. However, many smokers find it hard to quit or relapse after quitting. This study aims to explore the smoking behavior and influencing factors of inpatients who smoke. The survey will collect data on the demographic, clinical, psychological, and behavioral aspects of the participants, as well as their smoking history, nicotine dependence, withdrawal symptoms, confidence and motivation to quit, and perceived barriers and facilitators to quitting.

Eligibility criteria: Inclusion Criteria:

1. aged 18 and above;
2. smoke at least 1 cigarette daily;
3. willing to participate in this study

Exclusion Criteria:

1. Smokers who have mental illness or cognitive impairment;
2. Unable to complete the questionnaire survey

Primary outcomes:
measure: Smoking cessation rate at 6 months after discharge
timeFrame: 6 months after discharge
Secondary outcomes:
measure: Smoking reduction rate at 6 months after discharge
timeFrame: 6 months after discharge
measure: Quit attempt rate during the 6-month follow-up period
timeFrame: 6 months after discharge
Other outcomes:
Locations:
city: Zhuhai
country: China
facility: Xue Weng
state: Guangdong
Study officials:
affiliation: Beijing Normal University
name: Xue Weng
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03525912: Neuropsychiatric and Cardiovascular Side Effects in Ketamine Analgesic Infusions
Official title: Neuropsychiatric and Cardiovascular Side Effects in Ketamine Analgesic Infusions: a Prospective Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain, Postoperative
Ketamine Adverse Reaction
Lead sponsor: Universidad de Antioquia
Sponsor class: OTHER
First posted: 2018-05-16
Enrollment: 101
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: single group assignment interventional
Primary purpose: TREATMENT

Brief summary: Evaluation of neuropsychiatric and cardiovascular side effects of low dose ketamine analgesic infusion for postoperative pain

Detailed description: Postoperative pain is a world wide problem related with surgery. Multimodal analgesia may include ketamine, aimed to decrease opioid adverse effects in postoperative analgesia for major surgery, and risk of chronic postsurgical pain. Ketamine has shown efficacy as adjuvant in multimodal analgesia, however, neuropsychiatric and cardiovascular effects of ketamine at low doses in continue postoperative infusion are less known. This type of adverse effects may compromise appropriated recovery.

Objective

to determine frequency of delirium, agitation, sedation, hallucinations, bad dreams and cardiovascular changes associated with ketamine analgesic infusion treatment for postoperative pain.

Eligibility criteria: Inclusion Criteria:

- patient scheduled for abdominal, thoracic or orthopedic surgery

Exclusion Criteria:

cognitive disfunction psychiatric illness cardiovascular disease

Primary outcomes:
measure: Delirium
timeFrame: 2 days
Secondary outcomes:
measure: Agitation
timeFrame: 24 and 48 hours postoperatively
measure: Sedation
timeFrame: 24 and 48 hours postoperatively
Other outcomes:
measure: Hallucinations
timeFrame: 24 and 48 hours postoperatively
measure: Bad Dreams
timeFrame: 24 and 48 hours postoperatively
measure: Hypertension
timeFrame: 0, 24 and 48 hours postoperatively
measure: Tachycardia
timeFrame: 0, 24 and 48 hours postoperatively
Locations:
city: Medellin
country: Colombia
facility: hospital universitario San Vicente Fundacion
state: Antioquia
Study officials:
affiliation: Anesthesiology professor
name: Adriana M Cadavid, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gorlin AW, Rosenfeld DM, Ramakrishna H. Intravenous sub-anesthetic ketamine for perioperative analgesia. J Anaesthesiol Clin Pharmacol. 2016 Apr-Jun;32(2):160-7. doi: 10.4103/0970-9185.182085.
citation: Laskowski K, Stirling A, McKay WP, Lim HJ. A systematic review of intravenous ketamine for postoperative analgesia. Can J Anaesth. 2011 Oct;58(10):911-23. doi: 10.1007/s12630-011-9560-0. Epub 2011 Jul 20.
citation: Li L, Vlisides PE. Ketamine: 50 Years of Modulating the Mind. Front Hum Neurosci. 2016 Nov 29;10:612. doi: 10.3389/fnhum.2016.00612. eCollection 2016.
Clinical trial NCT01728012: Long-term Cardiovascular Risk Following Successful Renal Transplantation
Official title: The Prevalence of Cardiovascular Risk Factors in Patients More Than 10 Years Following Successful Renal Transplant.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Renal Transplant
Keywords: Successful transplantation
Long-term observation
Lead sponsor: Helse Stavanger HF
Sponsor class: OTHER_GOV
First posted: 2012-11-16
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients registered in the Norwegian Renal Registry with transplan more than 10 years ago.

Brief summary: Mineral metabolism disturbances occur early during the course of chronic kidney disease and eventually affect most patients. For how long such disturbances persist after a successful renal transplantation is mainly unknown. This study will investigate the prevalence of such disturbances in patients more than 10 years following a successful renal transplantation. The patients will be recruited from an existing registry in Norway.


Eligibility criteria: Inclusion Criteria:

* Registered in the Norwegian Renal Registry
* Documented elevated iPTH at Tx and 10 weeks post-tx
* Well functioning transplant 10 years following tx
* Signed informed consent

Exclusion Criteria:

* Lack of ability to comply with the protocol
* Refused written informed consent

Primary outcomes:
measure: Fibroblast growth factor 23 (FGF23)
timeFrame: More than 10 years after successful renal transplantation
Secondary outcomes:
measure: Intact parathyroid hormone (iPTH)
timeFrame: More than 10 years after successful renal transplantation
measure: Klotho
timeFrame: More than 10 years after successful renal transplantation
measure: Neutrophil gelatinase-associated lipocalin (NGAL)
timeFrame: More than 10 years after successful renal transplantation
Other outcomes:
Locations:
city: Stavanger
country: Norway
facility: Stavanger University Hospital
Study officials:
affiliation: Helse Stavanger HF
name: Inger Hjørdis Bleskestad, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05386212: The Impact of an Instructional Web-based Healthcare App for Relieving Back Pain From Spinal Compression Fractures
Official title: National Taipei University of Nursing and Health Science
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Back Pain Lower Back Chronic
Lead sponsor: National Taipei University of Nursing and Health Sciences
Sponsor class: OTHER
Collaborators: name: Cheng-Hsin General Hospital
First posted: 2022-05-23
Enrollment: 250
Sex: FEMALE
Minimum age (years): 45
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: postmenopausal women

Brief summary: With the expected rise of patients with osteoporosis-induced fractures, it has become increasingly urgent to design and use specialized health education materials aimed at easing pain and improving bodily functions

Detailed description: This study designed web-based dynamic pain relief instructions for women with spinal compression fractures. We collected patients' pain rating data the day before, one month after, and three months after providing the instructions.

Eligibility criteria: Inclusion Criteria:

* postmenopausal women

Exclusion Criteria:

* postmenopausal women

Primary outcomes:
measure: Comparison of back pain, and qualitative of life between groups
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taipei university of nursing and health science
state: Peito
city: Taipei
country: Taiwan
facility: Cheng Hsin General Hospital
city: Taipei
country: Taiwan
facility: National Taipei university of nursing and health science
Study officials:
affiliation: National Taipei University of Nursing and Health Sciences
name: Pei-Hung Liao
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04167046: Erector Spinae Block in First Rib Resection: a Monocentric Before-after Study
Official title: Bloc Des Muscles Erecteurs du Rachis Pour Chirurgie d'exérèse de première côte Dans le Cadre du Syndrome du défilé Cervico-thoracique: évaluation Avant-après au CHU d'Angers.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Thoracic Surgery
Lead sponsor: University Hospital, Angers
Sponsor class: OTHER_GOV
First posted: 2019-11-18
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients undergoing first rib resection for thoracic outlet syndrome

Brief summary: First rib resection surgery for thoracic outlet syndrome is associated with an intense postoperative pain. It leads to significant consumption of nonsteroidal anti-inflammatory drugs and opioids, and hospitalization for several days.

In our center, first rib resection surgery was usually performed under general anesthesia combined with diffuse local infiltration of the axillary fossa. Erector spinae block is an interfascial block where a local anesthetic is injected between the erector spinae muscle and the transverse process, in order to obtain a multimetameric analgesia. It has now shown its efficacy and its safety in thoracic and abdominal surgeries by decreasing the morphine consumption and pain scores. Since November 2018, this erector spinae block is systematically performed preoperatively for first rib resection in our center, in association with a general anesthesia. Patient satisfaction seems important but remains to be assessed objectively.

In a before-after study, our goal is to assess the impact of the use of erector spinae block on postoperative pain in the first rib resection surgery.


Eligibility criteria: Inclusion Criteria:

* First rib resection for thoracic outlet syndrome

Primary outcomes:
measure: Pain assessment at H+48
timeFrame: Day 2 after surgery
Secondary outcomes:
measure: Postoperative pain assessment at other times
timeFrame: Hour 2, Day 1, and Day 3 after surgery
measure: Total consumption of morphine (per and postoperative)
timeFrame: Hour 2, Day 1, Day 2 and Day 3 after surgery
measure: Frequency of adverse effects related to morphine Frequency of morphine side effects
timeFrame: Hour 2, Day 1, Day 2 and Day 3 after surgery
measure: Length of hospital stay
timeFrame: Through study completion, an average of 1 year
Other outcomes:
Locations:
city: Angers
country: France
facility: Département d'Anesthésie-Réanimation du CHU d'Angers
Study officials:
affiliation: University Hospital of Angers, France
name: Emmanuel Rineau, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03995446: Low-level Laser Acupuncture Reduces Postoperative Pain and Morphine-related Side Effects in Patients With Total Knee Arthroplasty:
Official title: Low-level Laser Acupuncture Reduces Postoperative Pain and Morphine-related Side Effects in Patients With Total Knee Arthroplasty: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Low-level Laser Acupuncture in Patients With Total Knee Arthroplasty
Keywords: Acupuncture points, low-level laser, postoperative pain, total knee arthroplasty
Lead sponsor: Taipei Veterans General Hospital, Taiwan
Sponsor class: OTHER_GOV
First posted: 2019-06-24
Enrollment: 82
Sex: ALL
Minimum age (years): 60
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Total knee arthroplasty is a common and effective surgical procedure for patients with end-stage knee osteoarthritis, and wound pain is still a problem for many of the patients.

Detailed description: Therefore, the purpose of this study was to apply low level laser therapy Measured variables included postoperative pain intensity, patient-controlled analgesia requirements, side effects caused by morphine, knee stiffness and wound pain in the daily activities of patients undergoing total knee arthroplasty. Data were collected between April 2018 and January 2019. Eighty-two knee osteoarthritis patients receiving total knee arthroplasty were recruited from one hospital and randomly, equally assigned to the laser acupuncture or control group. The LA group received the low-level laser therapy with 3 joules at each acupuncture point at Hour 2, Hour 6, Hour 10, Hour 24, Hour 48, and Hour 72 after surgery; whereas the control group received the same manner except for joule.

Eligibility criteria: Inclusion Criteria:

* age 60 years or older
* American Sociological Association (ASA) class I-III
* spinal anesthesia, consent to patient-controlled analgesia (PCA) and peripheral nerve block (PNB)
* return to the ward directly from the anesthesia recovery room.

Exclusion Criteria:

* cutaneous lesions at the application sites
* use of taking immunosuppressive agents
* received intra-articular steroid treatment
* opiate dependence
* sensitive to light
* epilepsy
* clinically significant cardiovascular diseases
* cancer
* systemic lupus erythematosus.

Primary outcomes:
measure: The Numerical Rating Scale (NRS)
timeFrame: the first 72 hours after the surgery
measure: Brief Pain Inventory (BPI)
timeFrame: the first 72 hours after the surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Veteran General Hospital : Taipei City, Taiwan 11217, R.O.C.
Study officials:
References:
citation: Huang CH, Yeh ML, Chen FP, Wu D. Low-level laser acupuncture reduces postoperative pain and morphine consumption in older patients with total knee arthroplasty: A randomized placebo-controlled trial. J Integr Med. 2022 Jul;20(4):321-328. doi: 10.1016/j.joim.2022.04.002. Epub 2022 Apr 9.
Clinical trial NCT02512146: The Expression of the Ionotropic Glutamate Receptors in Colon of IBS
Official title: The Expression of the Ionotropic Glutamate Receptors in Colon of IBS
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Keywords: IBS
Ionotropic glutamate receptors
Lead sponsor: Shandong University
Sponsor class: OTHER
First posted: 2015-07-30
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients underwent colonoscopy in Qilu Hospital outpatient and inpatient department.

Brief summary: The study aims to determine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms.

Detailed description: Ionotropic glutamate receptors participate in pain in nervous system. In this study,participants will examine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms.

Participants may futher study the mechanism using cell experiment.

Eligibility criteria: Inclusion Criteria:

Patients meeting IBS Rome III criteria. Asymptomatic individuals for health surveillance or patients for follow up after polypectomy.

Exclusion Criteria:

Patients with known cancers or abdominal surgery. Alarm symptoms such as anaemia, gastrointestinal bleeding or obstruction, marked weight loss, abdominal mass. Patients who are unwilling to sign or give the informed consent form. Patients with impaired cardiac, liver or renal function. Patients with coagulopathy. Patients with pregnancy or breastfeeding.

Primary outcomes:
measure: the expression of the ionotropic glutamate receptors
timeFrame: 4 months
measure: the relationship between the ionotropic glutamate receptors and IBS symptom
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Jinan
country: China
facility: Department of Gastroenterology, Qilu Hospital, Shandong University
state: Shandong
Study officials:
affiliation: Department of Gastroenterology, Qilu Hospital
name: xiuli zuo, PHD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06841146: Prediction of Adhesion by Sliding Sign
Official title: Prediction of Adhesion by Sliding Sign in Three or Above Cesarean Section
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Adhesions Abdominal
Keywords: adhesion
cesarean section
sliding sign
Lead sponsor: Sanliurfa Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2025-02-24
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Sliding sign will be checked by ultrasonography by transabdominal and transvaginal route before operation of patients that had cesarean section three or more. During cesarean section adhesions will be evaluated and noted. The correlation and predictive values of adhesion and sliding sign will be defined in our study.

Detailed description: Three or more cesarean section patients will be included in our study. In addition, inflammatory markers in complete blood count as neutrophil, lymphocyte, neutrophil/ lymphocyte ratio, pan immune inflammation value (PIV) will be recorded.

Eligibility criteria: Inclusion Criteria:

* all three and above number of cesarean section patients

Exclusion Criteria: placenta adhesion spectrum

-

Primary outcomes:
measure: predictive value of sliding sign for adhesions intraabdominally
timeFrame: before cesarean section
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: