Clinical trial NCT05339620: Effect of Implant Driver Facilitated Micro-osteo Perforation on the Rate of Tooth Movement.
Official title: Effect of Implant Driver Facilitated Micro-osteo Perforations on the Rate of Tooth Movement.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tooth Movement Techniques
Keywords: micro-osteoperforations, tooth movement, implant driver
Lead sponsor: Bahria University
Sponsor class: OTHER
First posted: 2022-04-21
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: we have conducted a split-mouth randomized clinical trial to study effects of implant induced micro-osteoperforations on the rate of tooth movement during canine retraction.

Detailed description: The experimental group will receive implant driver facilitated microosteoperforation on one side of the mouth( according to split mouth design) decided by random allocation.

After 3 months of extraction of upper first premolar ( according to planned orthodontic treatment), 3 microosteoperforation will be done with implant in an implant driver distal to canine. Surgical procedure will be done in local anesthesia, no flap will be raised. Alginate impressions will be taken before the procedure and 28 days after canine retraction has started, to measure the difference between rate of canine retraction on both sides. Measurement was done by a digital vernier caliper,

Eligibility criteria: Inclusion Criteria:

* • Male and female

  * Age 18- 45 years
  * Class 2 div 1
  * No systemic disease
  * No radiographic evidence of bone loss
  * No history of periodontal therapy
  * No current active periodontal disease
  * No smoking
  * No gingivitis or untreated caries
  * Probing depth \< 4mm in all teeth
  * Gingival index \< 1mm
  * Plaque index \< 1mm

Exclusion Criteria:

* Long term use of antibiotics, phenytoin,cyclosporine, anti inflammatory drugs, systemic corticosteroids and calcium channel blockers.
* Poor oral hygiene for more than 2 visits.
* Extreme skeletal class 2 malocclusion, overjet \> 10mm, anb\> 7
* Systemic disease
* Evidence of bone loss
* Past periodontal disease
* Current periodontal disease
* Smoking
* Gingivitis and caries
* Probing depth \> 4mm

Primary outcomes:
measure: Comparing rate of canine retraction between intervention and non-intervention side.
timeFrame: 28 days
Secondary outcomes:
Other outcomes:
Locations:
city: Karachi
country: Pakistan
facility: Bahria University Medical and Dental College
state: Sindh
Study officials:
References:
citation: Cheung T, Park J, Lee D, Kim C, Olson J, Javadi S, Lawson G, McCabe J, Moon W, Ting K, Hong C. Ability of mini-implant-facilitated micro-osteoperforations to accelerate tooth movement in rats. Am J Orthod Dentofacial Orthop. 2016 Dec;150(6):958-967. doi: 10.1016/j.ajodo.2016.04.030.
citation: Ozkan TH, Arici S. The effect of different micro-osteoperforation depths on the rate of orthodontic tooth movement: A single-center, single-blind, randomized clinical trial. Korean J Orthod. 2021 May 25;51(3):157-165. doi: 10.4041/kjod.2021.51.3.157.
citation: Aboalnaga AA, Salah Fayed MM, El-Ashmawi NA, Soliman SA. Effect of micro-osteoperforation on the rate of canine retraction: a split-mouth randomized controlled trial. Prog Orthod. 2019 Jun 3;20(1):21. doi: 10.1186/s40510-019-0274-0.
citation: Bolat Gumus E, Kinsiz E. Effects of miniscrew-facilitated micro-osteoperforations on the rate of orthodontic tooth movement : A split-mouth, randomized controlled trial. J Orofac Orthop. 2023 Apr;84(Suppl 2):104-110. doi: 10.1007/s00056-021-00371-6. Epub 2022 Jan 13.