Clinical trial NCT03667092: Exploration of Molecular Biomarkers for Lu-177 DOTATATE Therapy in Midgut Neuroendocrine Tumor
Official title: Pilot Study for Measuring Molecular Biomarkers and Their Capacity to Characterize Radionuclide Therapy With Lu-177 DOTATATE) in Metastatic G1-G2 Neuroendocrine Midgut Tumors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Midgut Neuroendocrine Tumors
Keywords: Lu-177 Dotatate
transcript analysis and variation
molecular biomarkers
midgut neuroendocrine tumors
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2018-09-12
Enrollment: 47
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Midgut neuroendocrine tumours present an increasing incidence and poor survival at 5 years with limited therapeutic options for metastatic, non-operable cases. Lu-177 Dotatate, targeting somatostatin receptors, is an internal vectorized radiotherapy using Lu-177, an ideal radionuclide for peptide radionuclide therapy. In NETTER-1 phase III randomized clinical trial, Lu-177 Dotatate proved its superiority in increasing progression free survival for midgut neuroendocrine tumors. This study hypothesize that finding biomarkers of individual radio sensitivity for this type of internal vectorized therapy would allow treatment personalization. The protocol aim at studying transcript variations induced by this therapy.

Detailed description: Internal vectorized therapy using Lu-177 Dotatate (abbreviated peptide receptor radionuclide therapy) was recently shown to improve progression free survival and response in metastatic progressive midgut neuroendocrine tumors (NETTER-1 phase III trial).

Lu-177 Dotatate is administered as a series of four consecutive intra veinous injections of an activity of 7.4 gigabequerel every 8 weeks.

In order to identify potential biomarkers of radio sensitivity to Lu-177 Dotatate, investigators aim to study the stability of gene/miRNA transcripts in the absence of Lu-177 Dotatate or at 6 months after treatment as well as the variations in transcript analysis after 2 Lu-177 Dotatate injections and at the end of the treatment.

Transcript variation analysis will be confronted and correlated with peripheral blood pharmacokinetic studies aimed at calculating time activity curves and provide biodosimetry information; other correlations with imaging modalities assessment of dosimetry or disease response to treatment or toxicity effects induced by Lu-177 Dotatate will also be studied.

Eligibility criteria: Inclusion Criteria:

* Patients ≥18 years old; histopathologically confirmed grade 1-2 midgut neuroendocrine tumor with documented progression during the year preceding inclusion upon RECIST criteria on computerized tomography, Octreoscan or Ga-68 positron emission tomography/computerized tomography
* Patients having an indication for Lu-177 Dotatate treatment validated during multidisciplinary meeting coordinated by Pr Rosine Guimbaud under RENATEN coordination;
* Measurable target lesions upon RECIST criteria
* Patients on somatostatin analogues treatment. Every somatostatin analogue injection should be organized to be administered 24 to 48 hours after each injection of Lu-177 Dotatate.
* All patients should be in a clinical state allowing them to continue treatment.
* Social security affiliation is mandatory.

Exclusion Criteria:

* Patients on chemotherapy or other targeted therapy within the 4 months preceding peptide receptor radionuclide therapy
* Fertile patients refusing active contraception ; pregnancy.
* Patients with prior chemotherapy or peptide receptor radionuclide therapy administration
* Patients with uncontrollable psychotic disorders
* Renal hepatic and medullary insufficiency

Primary outcomes:
measure: Peptide receptor radionuclide therapy radio-induction variation of radiosensibility/reparation genes
timeFrame: Change from before at during treatment
Secondary outcomes:
measure: Evaluation of gene transcript variations
timeFrame: during treatment and until 48 hours after treatment
measure: Evaluation of interindividual variability with NONMEN software
timeFrame: during treatment and until 48 hours after treatment
measure: Evaluation of therapeutic response according to RECIST criteria
timeFrame: 6 months post therapy
Other outcomes:
Locations:
city: Toulouse
country: France
facility: CHU de Toulouse
Study officials:
affiliation: University Hospital, Toulouse
name: Lavinia VIJA, MD, PhD
role: STUDY_CHAIR
References: