Clinical trial NCT03512938: Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis
Official title: Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Generalized Aggressive Periodontitis
Smoking
Keywords: Generalized aggressive periodontitis
Non-surgical periodontal therapy
Periodontopathogens
Smoking
Gingival crevicular fluid
Lead sponsor: Ege University
Sponsor class: OTHER
Collaborators: name: University of Glasgow
First posted: 2018-05-01
Enrollment: 27
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Smoking is the major preventable risk factor in the initiation and progression of periodontal diseases. Periodontitis risk was found to be 3.9 times higher among smokers aged between 19-30 years and 2.8 times higher among smokers aged 31-40 years compared to non-smokers. Aggressive periodontitis (AgP), is characterized by a rapid attachment loss usually incompatible with the amount of plaque and dental calculus. It is often not possible to predict the prognosis of treatment with various treatment options in cases of aggressive periodontitis. It was hypothesized that non-smoker patients with generalized aggressive periodontitis (GAgP) will respond better to conventional mechanical non-surgical periodontal therapy compared to the smokers. Therefore, the aim of this study was to evaluate the effects of smoking on the outcomes of non-surgical periodontal treatment in terms of the clinical, biochemical and microbiological parameters.


Eligibility criteria: Inclusion Criteria:

* Having at least six permanent teeth, including incisors and/or first molars with severe periodontal disease
* Having at least one site with probing depth (PD) and clinical attachment level (CAL) ≥5 mm and six teeth other than first molars and incisors with similar PD and CAL measurements
* Familial aggregation

Exclusion Criteria:

* Medical disorders such as diabetes mellitus, immunological disorders
* Having an antibiotic or periodontal treatment in the last 6 months
* Having \<15 teeth

Primary outcomes:
measure: Change in Clinical Attachment Level (CAL)
timeFrame: Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy
Secondary outcomes:
measure: Change in Probing Depth (PD)
timeFrame: Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy
measure: Change in Bleeding on Probing (BoP)
timeFrame: Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy
measure: Change in Plaque Index (PI)
timeFrame: Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy
measure: Changing of the salivary biomarkers
timeFrame: Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy
measure: Changing of the serum biomarkers
timeFrame: Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy
measure: Changing of the gingival crevicular fluid (GCF) biomarkers
timeFrame: Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy
measure: Changing of the amount of pathogen microorganisms
timeFrame: Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy
Other outcomes:
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