Clinical trial NCT04857281: Non-invasive Vagal Nerve Stimulation (nVNS) for Symptomatic Exacerbation of Nausea in Patients With Gastroparesis and Related Disorders
Official title: Non-invasive Vagal Nerve Stimulation (nVNS) for Symptomatic Exacerbation of Nausea in Patients With Gastroparesis and Related Disorders
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Unexplained Nausea and Vomiting
Gastroparesis
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
Collaborators: name: ElectroCore INC
First posted: 2021-04-23
Enrollment: 49
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The hypothesis of this pilot study is that nVNS will result in relief of nausea by modulation of vagal nerve activity. nVNS is the first non-invasive, handheld medical device applied on the side of the neck and sends gentle, patented mild electrical stimulation through the skin to activate the vagus nerve. nVNS offers a potential alternative to Gastric electrical stimulation (GES) that could eliminate significant risks of injury or illness or identify likely responders to implantable neurostimulator including implanted VNS (iVNS). nVNS could provide a more effective and safer alternative to the use of traditional rescue medications.

Detailed description: The patient will receive the gammaCore (nVNS) device and a video instruction will be use to explain how to properly handle the device. Treatment can only start after eligibility has been fully checked and all data collected at screening have been keyed into the trial database.

The patient will be instructed to use the nVNS in place of the rescue medications. When the nauseas gets bad enough that they feel to use a rescue medication they will first use the device on one side of the neck for two 2-minute stimulations and wait fifteen minutes to check if the stimulation works. If this does not help either, they will stimulate with an additional 2 stimulations and wait for another fifteen minutes. If there is no improvement rescue medication will be used. nVNS can be used up to, but no more than, 8 times a day.

Eligibility criteria: Inclusion Criteria:

* Age 18 years or older at registration.
* Diagnosis of gastroparesis as documented by gastric emptying scintigraphy (4-hour emptying after a low-fat meal with any combination of 2- and 4-hour retention of \>60% and 10%, respectively), or Chronic Unexplained Nausea and Vomiting (CUNV).
* Ongoing symptoms (i.e. Nausea and vomiting, bloating, and abdominal pain) with a nausea score of 3 or more on the patient assessment of upper gastrointestinal disorders-symptom severity index (PAGI-SYM) scale at baseline (moderate to severe nausea).
* Exclusion of other causes of symptoms such as mechanical gastrointestinal obstruction, uncontrolled esophagitis, peptic ulcer disease, etc. By standard radiographic or endoscopic tests.
* Use of the following medications on an as-needed basis: ondansetron, promethazine or prochlorperazine but no more than four times a day.

Exclusion Criteria:

* Another active disorder, which could explain symptoms in the opinion of the investigator.
* Age \< than 18 years.
* Pregnancy or nursing.
* A previous surgery of the upper gastrointestinal tract, including vagotomy.
* Use of narcotics more than 3 days per week.
* History of prolonged QT interval or a history of clinically significant arrhythmia.
* Abnormal baseline ECG (e.g. Second- and third-degree heart block, atrial fibrillation, atrial flutter, recent history of ventricular tachycardia or ventricular fibrillation, or clinically significant premature ventricular contraction).
* Previous bilateral or right cervical vagotomy.
* Uncontrolled high blood pressure.
* Currently implanted with an electrical and/or neurostimulator device, including but not limited to cardiac pacemaker or defibrillator, vagal neurostimulator, deep brain stimulator, spinal stimulator, bone growth stimulator, or cochlear implant.
* History of carotid endarterectomy or vascular neck surgery on the right side.
* Implanted with metal cervical spine hardware or has a metallic implant near the gammaCore stimulation site.
* Any other condition, which in the opinion of the investigator would impede compliance or hinder the completion of the study.
* Failure to give informed consent.

Primary outcomes:
measure: Average Daily Use of Rescue Medications for Exacerbation of Nausea/Vomiting.
timeFrame: Baseline, 4, 6, 10 and 12 weeks of study participation
Secondary outcomes:
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Johns Hopkins Bayview Medical Center
state: Maryland
Study officials:
affiliation: Johns Hopkins School of Medicine
name: Jay Pasricha, MD
role: PRINCIPAL_INVESTIGATOR
References: