Clinical trial NCT06529068: Cardiovascular Response to Isometric BFR Exercise
Official title: Blood Pressure Responses to Isometric Blood Flow Restriction Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Blood Pressure
Lead sponsor: University of Texas at Austin
Sponsor class: OTHER
First posted: 2024-07-31
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The goal of this interventional study is to evaluate the acute impact of isometric blood flow restriction (BFR) exercise on blood pressure and other cardiovascular functions in healthy young adult volunteers. The main question it aims to answer is:

The investigators hypothesize that isometric BFR exercise with a wide-rigid cuff would lead to greater blood pressure and other cardiovascular responses and that these cardiovascular responses would be greater under isometric BFR exercise with narrow-elastic bands compared with the control condition (no cuff).

Participants will perform isometric exercises in 3 laboratory visits with different exercise conditions) no cuff control 2) BFR with wide-rigid cuff 3) BFR with narrow-elastic band.


Eligibility criteria: Inclusion Criteria:

- Apparently healthy young adults aged between 18 - 40 years old and signed the informed consent.

Exclusion Criteria:

* Abnormal clotting times
* Acid-base imbalance/acidosis
* Arterial calcification
* Atherosclerotic vessels
* Cardiopulmonary conditions
* Diabetes
* Dialysis/central venous access
* General/local infection
* High intracranial pressure
* Hip, pelvis, or femur fracture
* History of venous thromboembolism
* Hypertension
* Immobility for greater than 48 hours in the past month
* Immobilizing cast
* Implanted medical device
* Lymphectomies
* Obesity
* Open fracture
* Open or unhealed soft tissue injuries
* Paralysis
* Peripheral vascular disease
* Pregnancy/postpartum
* Prior revascularization
* Renal compromise
* Severe crush injuries
* Sickle cell trait/anemia
* Skin grafts
* Stroke
* Temporary nerve damage
* Thrombophilia
* Tumor/cancer
* Varicose veins
* Vascular grafting

Primary outcomes:
measure: Systolic blood pressure and diastolic blood pressure
timeFrame: 20 minutes
measure: Brachial artery diameter evaluated by an ultrasound machine
timeFrame: Before and 20 minutes after exercise
measure: Heart rate
timeFrame: 20 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Austin
country: United States
facility: Cardiovascular Aging Research Laboratory
state: Texas
Study officials:
References:
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citation: Early KS, Rockhill M, Bryan A, Tyo B, Buuck D, McGinty J. EFFECT OF BLOOD FLOW RESTRICTION TRAINING ON MUSCULAR PERFORMANCE, PAIN AND VASCULAR FUNCTION. Int J Sports Phys Ther. 2020 Dec;15(6):892-900. doi: 10.26603/ijspt20200892.
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citation: Schneider AC, Hughes WE, Ueda K, Bock JM, Casey DP. Reduced blood pressure responsiveness to skeletal muscle metaboreflex activation in older adults following inorganic nitrate supplementation. Nitric Oxide. 2018 Aug 1;78:81-88. doi: 10.1016/j.niox.2018.05.010. Epub 2018 Jun 1.