Clinical trial NCT01932008: Evaluation of the Bone Mineral Density and Muscle Mass in Patients Post Coronary Artery Bypass Graft Surgery With Chronic Kidney Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Bypass Graft
Chronic Kidney Disease
Keywords: Coronary artery bypass grafting
Chronic kidney disease
Body composition
Physical activity
Physical function
Lead sponsor: Far Eastern Memorial Hospital
Sponsor class: OTHER
First posted: 2013-08-30
Enrollment: 60
Sex: MALE
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: All patients who underwent CABG at the Department of Cardiovascular Center at Far-Eastern Memorial Hospital since January 2000 were selected for recruitment to this study.Thirty male patients after CABG with CKD and 30 matched controls were recruited (ages between 40-75 years old).

Brief summary: The purposes of this study are: (1) to compare the body composition, physical activity, physical function, and quality of life between patients with and without CKD after CABG; and (2) to analyze the relationships among body composition, physical activity, and physical function in this population. It is expected that patients after CABG with CKD have the worse body composition, physical function, and quality of life than patients after CABG without CKD; and patients with higher physical activity levels have the better body composition, physical function, and quality of life.

Detailed description: It has been reported that cardiac disease and renal disease frequently coexisted. Recently, the term cardiorenal syndrome was used to describe the interaction between heart and kidney. Chronic kidney disease (CKD) has become increasingly recognized as an independent risk factor of cardiovascular disease, and the cardiovascular disease is one of most severe complication in patients with CKD. Previous studies have showed the changes in body composition, physical inactivity, decreased physical function, and poor quality of life existed in patients with either cardiovascular disease or CKD. Patients concomitant with cardiovascular disease and kidney insufficiency were expected to significantly increase physical dysfunction. However, few studies addressed on these alterations in patients after coronary artery bypass grafting (CABG) with CKD were reported.

Eligibility criteria: Inclusion Criteria:

* patients undergoing CABG without valve surgery
* chronic kidney disease(matched group: without CKD)

Exclusion Criteria:

1. heart transplantation or redo CABG
2. amputation,
3. cerebrovascular disease or any others disease with limbs dysfunction,
4. lung deficit,
5. cancer,
6. cognitive disorders.

Primary outcomes:
measure: lean body mass and body fat
timeFrame: The participants were followed at one time points after operation in past 10 years
Secondary outcomes:
measure: physical activity
timeFrame: The participants were followed at one time points after operation in past 10 years
measure: physical function
timeFrame: The participants were followed at one time points after operation in past 10 years
measure: quality of life
timeFrame: The participants were followed at one time points after operation in past 10 years
Other outcomes:
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