Clinical trial NCT04025723: Differences in Rate of Recovery Between Young and Middle-aged Men After Downhill Running
Official title: Differences in Rate of Recovery Between Young and Middle-aged Men After Downhill Running
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Lead sponsor: Tel Aviv University
Sponsor class: OTHER
First posted: 2019-07-19
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Young (18-30 y) and middle aged (35-50 y) men will perform 60 min of downhill running
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this study is to evaluate differences in rate of recovery between young and middle-aged men after prolonged (downhill) running. Thirty healthy young (n=15, 18-30 y) and middle-aged (n=15, 35-50y) men will be recruited for this study. Participants will perform 60 minutes of downhill run at 65% of their maximal oxygen consumption (VO2max). Recovery parameters will be evaluated during 48 hours following the downhill protocol, and will include changes in performance tests, inflammatory markers, muscle integrity and heart-rate variability. Questioners will be used to evaluate muscle soreness and fatigue. We hypothesized that middle-aged males will have longer rate of recovery following the downhill running protocol, as compared to younger age males.


Eligibility criteria: Inclusion Criteria:

* Active man which perform a minimum of 150 minutes/week of exercise
* Able to complete 60 min run.

Exclusion Criteria:

* Injuries in lower body
* cardio-respiratory disease
* supplementing with performance enhancing supplements

Primary outcomes:
measure: Changes over time in Maximal voluntary contraction (MVC) of the Musculus quadriceps femoris
timeFrame: MVC will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running
measure: Changes over time in vertical jump (VJ)
timeFrame: VJ will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running
measure: Changes over time in stride length
timeFrame: Stride length will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running
measure: Changes over time in stride frequency
timeFrame: Stride frequency will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running
Secondary outcomes:
measure: Changes over time in the concentration of circulating interleukin -6 (IL-6)
timeFrame: The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running
measure: Changes over time in the concentration of circulating interleukin -10 (IL-10)
timeFrame: The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running
measure: Changes over time in the concentration of circulating interleukin -1 receptor antagonist (IL-1ra)
timeFrame: The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running
measure: Changes over time in the concentration of circulating tumor necrosis factor alpha (TNFa)
timeFrame: The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running
measure: Changes over time in the concentration of circulating c-reactive protein (CRP)
timeFrame: The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running
measure: Changes over time in the concentration of circulating creatine kinase (CK)
timeFrame: The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running
measure: Changes over time in the concentration of circulating lactate dehydrogenase (LDH)
timeFrame: The circulating parameters will be measured before intervention, immediately after, 30, 60, 120 minutes, 24 and 48 h post intervention.
measure: Changes over time in muscle fibers morphology
timeFrame: MRI will be conducted up to 1 week before the intervention (screening day, Day -1) and after 24 hours (Day 1) or 48 hours (Day 2) post downhill running.
measure: Changes over time in delayed-onset muscle soreness (DOMS)
timeFrame: DOMS will be measured before intervention, immediately after, 30, 60, 120 minutes after (Day 0), 24 hours (Day 1) and 48 hours (Day 2) post downhill running.
measure: Changes over time in Mood States
timeFrame: Changes in Mood States will be measured before intervention, immediately after, 30, 60, 120 minutes after (Day 0), 24 hours (Day 1) and 48 hours (Day 2) post downhill running.
measure: Changes over time in total fatigue
timeFrame: Changes in total fatigue will be measured before intervention, immediately after, 30, 60, 120 minutes after (Day 0), 24 hours (Day 1) and 48 hours (Day 2) post downhill running.
measure: Changes over time in none-specific muscle fatigue- MVC of the forearm
timeFrame: None-specific muscle fatigue tests will be measured before intervention, immediately after, 30, 60, 120 minutes after (Day 0), 24 hours (Day 1) and 48 hours (Day 2) post downhill running.
measure: Changes over time in heart rate variability (HRV)
timeFrame: Between 3 to 5 days before screening day (Day -1) and downhill running (Day 0) for baseline assessment, and after the downhill running (Day 0) until day 2
Other outcomes:
Locations:
city: Tel Aviv
country: Israel
facility: Tel Aviv University
Study officials:
References: