louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06202495: Dentine Hypersensitivity Treated With Laser and Fluoride.
Official title: Dentine Hypersensitivity Treated With Diode Laser and Amino Fluoride: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Sensitive Dentin
Keywords: Dentine hypersensitivity
fluoride
laser
Lead sponsor: University of Pavia
Sponsor class: OTHER
First posted: 2024-01-11
Enrollment: 43
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the present report is to evaluate the amino fluoride gel with or without application of diode laser on pain due to dentine hypersensitivity.

NRS (numerical rating scale) index will be used to evaluate the pain suffered by each patient after cold air blow stimulus.

After treatment application, the follow-up timing planned for each patient will be at 1 week, 1 month, 3 months and 6 months

Detailed description: The aim of the present report is to evaluate the amino fluoride gel with or without application of diode laser on pain due to dentine hypersensitivity.

The study is designed with a split mouth design. NRS (numerical rating scale) index will be used to evaluate the pain suffered by each patient. The pain response will be stimulated by thermal urge (cold air blow). Teeth will be divided in two groups. The treatment group, treated with 980nm diode laser and amino fluoride gel; the control group, treated only with amino fluoride gel.

The follow-up timing planned for each patient will be at 1 week, 1 month, 3 months and 6 months. In these follow-up sessions a revaluation of the pain response is performed using the NRS index.

Eligibility criteria: Inclusion Criteria:

* Teeth in good periodontal health
* Good oral hygiene
* Dentine hypersensitivity: NRS (Numerical Rating Scale) ≥ 3

Exclusion Criteria:

* Teeth local disease or fractures in treatment area
* Irreversible teeth necrosis or pulpitis
* Definitive restorations or veneers
* Recent use of painkillers or anti-inflammatory drugs,
* Treatment for dentine Hypersensitivity less than 6 months before the study start
* Therapies contraindication

Primary outcomes:
measure: NRS (numerical rating scale)
timeFrame: Before treatment and 1 week, 1 month, 3 months, 6 months after treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Catanzaro
country: Italy
facility: A.O. Mater Domini, U.O. Odontoiatria, University of Catanzaro "Magna Græcia".
Study officials:
affiliation: Unit of Dental Hygiene - Section of Dentistry - Dep of Clin Surg Diagn Ped Sci - University of Pavia
name: Andrea Scribante, DDS PhD MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06870695: Safety and Efficiency of Electrocautery De-Epithelization in Mammoplasty
Official title: Safety and Efficiency of Electrocautery De-Epithelization in Mammoplasty
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Safety
Efficiency
Electrocautery
De-Epithelization
Mammoplasty
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2025-03-11
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This retrospective study was conducted on 100 females patients aged 18 years or older who were scheduled to undergo mammoplasty at Tanta University Hospitals, Egypt between July 2024 and February 2025

Brief summary: The aim of this study is to evaluate safety and efficiency of electrocautery de-epithelization in mammoplasty.

Detailed description: Mammoplasty is the fifth most commonly performed by plastic surgeons worldwide to improve symptomatology resulting from macromastia.

One of the key stages in a breast reduction or augmentation surgery is the de-epithelization process. De-epithelialization is the first stage of reduction mammoplasty in techniques that use dermal, dermo-glandular pedicles. Traditional methods of de-epithelization include manual dissection or mechanical scraping as time-consuming and demanding by most surgeons, especially when the breasts are large and when there is no assistant available.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years.
* Patients undergoing mammoplasty.

Exclusion Criteria:

* Patients with active infections or open wounds at the surgical site.
* Individuals with known hypersensitivity or adverse reactions to electrocautery.
* Pregnant or lactating women.
* Patients with uncontrolled diabetes or coagulation disorders.
* History of psychiatric illness.
* Patients undergoing secondary or repeat breast reduction procedures.

Primary outcomes:
measure: Operative time
timeFrame: Intraoperatively
Secondary outcomes:
measure: Degree of pain
timeFrame: 3 days after surgery
measure: De-epithelization time
timeFrame: Intraoperatively
measure: Time to achieve hemostasis
timeFrame: Intraoperatively
measure: Duration of drain placement
timeFrame: Intraoperatively
measure: Blood loss
timeFrame: Intraoperatively
measure: Wound healing time
timeFrame: 6 weeks after surgery
measure: Incidence of adverse events
timeFrame: 6 weeks after surgery
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Tanta University
state: El-Gharbia
Study officials:
References:
Clinical trial NCT03468595: Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis
Official title: Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis With Subgingival Ultrasonic Instrumentation in Periodontitis Patients: A Randomized Clinical Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Halitosis
Keywords: Listerine, CHX
Lead sponsor: Near East University, Turkey
Sponsor class: OTHER
First posted: 2018-03-16
Enrollment: 90
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aim of this trial was to establish the clinical efficacy of Listerine and chlorhexidine (CHX) when used as a cooling agent with ultrasonic instrumentation, on periodontal parameters and halitosis.

Ninety patients with periodontal disease participated for the study. Individuals were randomly selected to a control and test groups. At baseline, all subjects completed a questionnaire and carried out an examination. Standard periodontal outcome variables were assessed. For both groups, the plaque index (PI), gingival index (GI), pocket depth (PD), bleeding on probing (BOP) and clinical attachment level (CAL) scores were enrolled at baseline and after 30 days. Volatile sulphur compound (VSC) levels were evaluated by a Halimeter (Interscan Corp., Chatsworth, CA, USA) at baseline (T0), immediately after treatment (T1), and at 7 (T2), 14 (T3) and 30 days (T4).


Eligibility criteria: Inclusion Criteria:

* In the present trial, who had periodontitis from patients undergoing periodontal treatment at the Department of Periodontology of our institution

Exclusion Criteria:

* Individuals who presented any systemic disorders which cause halitosis (diabetes mellitus, nephropathy, liver disease, gastrointestinal diseases, respiratory problems), pregnancy or lactation, individuals who had taken antibiotics over the last 6 months or permanently used any drugs, individuals who had any form of periodontal treatment within 6 months prior to the study.

Primary outcomes:
measure: Periodontal Pocket Depth (PPD)
timeFrame: 30 day
Secondary outcomes:
measure: halimeter values
timeFrame: 30 day
Other outcomes:
Locations:
Study officials:
affiliation: Near East University, Faculty of Dentistry
name: Hasan Guney YILMAZ, DDS, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT02220595: A Comparison of Cognitive Function After Carotid Endarterectomy and Stenting
Official title: A Comparison of Cognitive Function After Carotid Endarterectomy and Stenting
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Carotid Artery Occlusive Disease
Keywords: Stenting
Endarterectomy
Cognition
Lead sponsor: Baylor College of Medicine
Sponsor class: OTHER
First posted: 2014-08-20
Enrollment: 60
Sex: ALL
Minimum age (years): 30
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study compares cognitive function after carotid endarterectomy and stenting.


Eligibility criteria: Inclusion Criteria:

* Carotid artery occlusive disease, asymptomatic greater than 80% with CTA or carotid duplex

Exclusion Criteria:

* Contraindication for carotid endarterectomy or stenting

Primary outcomes:
measure: Difference in RAVLT score
timeFrame: Six weeks
Secondary outcomes:
measure: Cognitive tests for attention, memory, processing speed, mood, motor function, visual-spatial skills, executive functioning
timeFrame: Six weeks and six months
measure: Cognitive tests of attention
timeFrame: Six weeks
measure: Cognitive tests for memory
timeFrame: Six weeks
measure: Cognitive tests for processing speed
timeFrame: Six weeks
measure: Cognitive tests of mood
timeFrame: Six weeks
measure: Tests of motor function
timeFrame: Six weeks
measure: Cognitive tests of visual-spatial skills
timeFrame: Six weeks
measure: Cognitive tests of executive functioning
timeFrame: Six weeks
measure: Cognitive tests of attention
timeFrame: Six months
measure: Cognitive tests of memory
timeFrame: Six weeks
measure: Cognitive tests of processing speed
timeFrame: Six months
measure: Cognitive tests of mood
timeFrame: Six months
measure: Tests of motor function
timeFrame: Six months
measure: Cognitive tests of visual-spatial skills
timeFrame: Six months
measure: Cognitive tests of executive functioning
timeFrame: Six months
measure: Difference in new ischemic infarcts in Diffusion - weighted MRI
timeFrame: Six weeks
measure: Difference in new ischemic infarcts in Diffusion - weighted MRI
timeFrame: Six months
Other outcomes:
Locations:
city: Houston
country: United States
facility: Michael E. Debakey VAMC
state: Texas
Study officials:
References:
Clinical trial NCT01682395: Best Management of Sigmoid Volvulus: A Prospective Randomized Trial
Official title: Best Management of Sigmoid Volvulus: A Prospective Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intestinal Volvulus
Colon, Sigmoid
Keywords: Intestinal volvulus
Colon, sigmoid
Anastomosis, surgical
Anastomotic leak
Malawi
Developing Country
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
First posted: 2012-09-10
Enrollment: 29
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to obtain a better understanding of the best management of left-sided colonic emergencies.

Detailed description: Participants: Patients 18 years or older presenting to Kamuzu Central Hospital in Lilongwe Malawi with sigmoid volvulus will be eligible for inclusion.

Procedures (methods): This is a prospective randomized trial. Subjects will be randomized during surgery to receive resection and anastomosis or mesosigmoidopexy (for non-gangrenous sigmoid volvulus), and resection and anastomosis or Hartmann's procedure (for gangrenous sigmoid volvulus).

Eligibility criteria: Inclusion Criteria:

* clinical suspicion of sigmoid volvulus as deemed by the surgeon on duty

Exclusion Criteria:

* pregnancy,
* age under 18 years,
* prisoners

Primary outcomes:
measure: Mortality
timeFrame: 30-Day
Secondary outcomes:
measure: Recurrence of Sigmoid Volvulus
timeFrame: 3 Year
measure: Surgical Site Infection
timeFrame: 30-Day
Other outcomes:
measure: Anastomotic Leak
timeFrame: 30-Day
measure: Stomal Complications
timeFrame: 3 Year
Locations:
city: Lilongwe
country: Malawi
facility: Kamuzu Central Hospital
Study officials:
affiliation: UNC Chapel Hill Department of Surgery
name: Jonathan C Samuel, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Raveenthiran V, Madiba TE, Atamanalp SS, De U. Volvulus of the sigmoid colon. Colorectal Dis. 2010 Jul;12(7 Online):e1-17. doi: 10.1111/j.1463-1318.2010.02262.x. Epub 2010 Mar 10.
citation: Akinkuotu A, Samuel JC, Msiska N, Mvula C, Charles AG. The role of the anatomy of the sigmoid colon in developing sigmoid volvulus: a case-control study. Clin Anat. 2011 Jul;24(5):634-7. doi: 10.1002/ca.21131. Epub 2011 Feb 14.
citation: Samuel JC, Msiska N, Muyco AP, Cairns BA, Charles AG. An observational study addressing the anatomic basis of mesosigmoidopexy as a rational treatment of non-gangrenous sigmoid volvulus. Trop Doct. 2012 Jan;42(1):44-5. doi: 10.1258/td.2011.110317. Epub 2011 Dec 19.
Clinical trial NCT03343795: Oral Versus Parental Progesterone in the Management of Preterm Labor
Official title: Oral Versus Parental Progesterone in the Management of Preterm Labor
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Preterm Labor
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-11-17
Enrollment: 80
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Preterm birth, defined as delivery at less than 37 weeks gestation, complicates approximately 12% of pregnancies in the United States

Preterm delivery has been, and remains, the most important challenge to modern obstetrics. In 2009, 13 million babies were born preterm, 11 million in Africa and Asia and 500,000 in the USA, The highest rates of preterm birth are in Africa (11.9%) and North America (10.6%)


Eligibility criteria: Inclusion Criteria:

1. Past history of one or more spontaneous preterm labor.
2. Singleton pregnancy.
3. Pregnancy of less than 20 weeks of gestation

Exclusion Criteria:

1. Women on tocolytic drugs .
2. Underwent cervical cerclage in this pregnancy .
3. Multiple gestations .
4. Major fetal congenital malformations .
5. Pregnancy 0f more than 20 weeks gestation .

Primary outcomes:
measure: the rate of preterm labor
timeFrame: 10 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut Faculty of Medicine
Study officials:
References:
Clinical trial NCT00551395: Timing of Treatment Completion in Staged Selective Laser Trabeculoplasty (SLT): Early vs. Late Completion
Official title: Timing of Treatment Completion in Staged Selective Laser Trabeculoplasty (SLT): Early vs. Late Completion
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Glaucoma
Keywords: glaucoma
laser
trabeculoplasty
Lead sponsor: Queen's University
Sponsor class: OTHER
First posted: 2007-10-31
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will evaluate the effect of the timing of treatment completion in two-staged selective laser trabeculoplasty therapy on intraocular pressure lowering effect.

Detailed description: SLT therapy is used as an IOP lowering agent in patients with glaucoma. It is unknown whether the timing of a 2-staged approach to the laser therapy will result in better IOP lowering effect.

This study will evaluate the timing (early vs. late completion of SLT therapy) and determined the IOP lowering effect following the interventions.

Arm 1: Early Completion SLT

180 degrees of SLT on Day 1, 180 degrees of SLT on the other 180 degrees on Day 2

Arm 2: Late Completion SLT

180 degrees of SLT on Day 1, 180 degrees of SLT on the other 180 degrees at the 1 month follow up visit.

Primary Outcome: IOP (mmHg).

Eligibility criteria: Inclusion Criteria:

* 18 years of age
* primary open angle glaucoma or pseudoexfoliation glaucoma

Exclusion Criteria:

* Unable to give informed consent

Primary outcomes:
measure: intraocular pressure lowering
timeFrame: 1 month following procedure
Secondary outcomes:
measure: intraocular pressure lowering
timeFrame: 3, 6, 12 and 24 months following procedure
Other outcomes:
Locations:
city: Kingston
country: Canada
facility: Hotel Dieu Hospital & Queen's University
state: Ontario
Study officials:
affiliation: Queen's University, Kingston, Canada
name: Robert J Campbell, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Rolim-de-Moura CR, Paranhos A Jr, Loutfi M, Burton D, Wormald R, Evans JR. Laser trabeculoplasty for open-angle glaucoma and ocular hypertension. Cochrane Database Syst Rev. 2022 Aug 9;8(8):CD003919. doi: 10.1002/14651858.CD003919.pub3.
Clinical trial NCT05259995: Sustained Acoustic Medicine Ultrasound Diathermy Clinical Performance
Official title: Verification of Performance of Sustained Acoustic Medicine Device Designs Diathermy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Measurement of Diathermy on Anatomical Locations of the Body
Lead sponsor: ZetrOZ, Inc.
Sponsor class: INDUSTRY
First posted: 2022-03-02
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to measure diathermy performance of Sustained Acoustic Medicine Devices with commercially available ultrasound gel coupling patches.


Eligibility criteria: Inclusion Criteria:

• Healthy Volunteer

Exclusion Criteria:

* Is pregnant/nursing.
* Has an active infection, open sores, or wounds in the treatment area.

Primary outcomes:
measure: Ultrasound Diathermy (Degrees Centigrade)
timeFrame: 0 - 4 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Trumbull
country: United States
facility: ZetrOZ
state: Connecticut
Study officials:
affiliation: ZetrOZ, Inc.
name: George Lewis, PHD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Rigby JH, Taggart RM, Stratton KL, Lewis GK Jr, Draper DO. Intramuscular Heating Characteristics of Multihour Low-Intensity Therapeutic Ultrasound. J Athl Train. 2015 Nov;50(11):1158-64. doi: 10.4085/1062-6050-50.11.03. Epub 2015 Oct 28.
Clinical trial NCT02994095: A Pilot Study of a Community Health Agent-led Diabetes Self-Management Program
Official title: A Pilot Study of a Community Health Agent-led Diabetes Self-Management Program Using Motivational Interviewing-based Approaches in a Public Primary Care Center in São Paulo, Brazil
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Type2 Diabetes
Lead sponsor: University of Michigan
Sponsor class: OTHER
First posted: 2016-12-15
Enrollment: 57
Sex: ALL
Minimum age (years): 21
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: This was a pilot study to assess the feasibility and acceptability of training Community Health Agents in Motivational Interviewing in real-life primary care centers.

Detailed description: Rates of noncommunicable diseases (NCDs) such as type 2 diabetes are escalating in low and middle-income countries such as Brazil. Scalable primary care-based interventions are needed to improve self-management and clinical outcomes of adults with diabetes. This pilot study examines the feasibility, acceptability, and outcomes of training community health agents (CHAs) in Motivational Interviewing (MI)-based counseling for patients with poorly controlled diabetes in a primary care center in São Paulo, Brazil.

Nineteen salaried CHAs participated in 32 hours of training in MI and behavioral action planning. With support from booster training sessions, they used these skills in their regular monthly home visits over a 6 month period with 57 diabetes patients with baseline HbA1cs \> 7.0%. The primary outcome was patients' reports of the quality of diabetes care as measured by the Portuguese version of the Patient Assessment of Chronic Illness Care (PACIC) scale. Secondary outcomes included changes in patients' reported diabetes self-management behaviors and in A1c, blood pressure, cholesterol and triglycerides. CHAs' fidelity to and experiences with the intervention were also assessed.

Eligibility criteria: Inclusion Criteria:

* Adult patients with T2 diabetes who received care at the primary care center
* A1c\>7.0% in prior six months

Exclusion Criteria:

* Age\> 75
* being pregnant
* having terminal health condition or other conditions that would impede participation such as dementia and mental illness

Primary outcomes:
measure: PACIC score
timeFrame: Six months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of Michigan
name: Michele Heisler, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: do Valle Nascimento TM, Resnicow K, Nery M, Brentani A, Kaselitz E, Agrawal P, Mand S, Heisler M. A pilot study of a Community Health Agent-led type 2 diabetes self-management program using Motivational Interviewing-based approaches in a public primary care center in Sao Paulo, Brazil. BMC Health Serv Res. 2017 Jan 13;17(1):32. doi: 10.1186/s12913-016-1968-3.
Clinical trial NCT06530095: We Compared the Covid-19 Acute Respiratory Distress Syndrome (ARDS) Patients Who Applied Prone Positioning for16-24 Hours vs 24-48 Hours
Official title: ''Impact of Early vs. Delayed Prone Positioning on Oxygenation and Mortality in COVID-19 ARDS Patients: A Retrospective Analysis''
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Morality
Oxygenation Indices
Hypoxia
Lead sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Sponsor class: OTHER_GOV
First posted: 2024-07-31
Enrollment: 350
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who have been admitted in ICU and diagnosed with Covid-19 ARDS.

Brief summary: The goal of this study is to understand if there is any improvement on oxygenation of patients diagnosed with Covid-19 ARDS patients when we extend the duration of prone positioning.

Second outcome of the study is to investigate mortality of patients when we extend the duration of prone positioning.


Eligibility criteria: Inclusion Criteria:

COVİD 19 ARDS patients patients who have been intubated for 48 hours and more

Exclusion Criteria:

Pediatric patients Patients who extubated in less than 48 hours Patients with Lung and pleural malignancies

Primary outcomes:
measure: Oxygen Saturation Index (OSI)
timeFrame: 48 hours
measure: Oxygenation Index
timeFrame: 48 hours
Secondary outcomes:
measure: ICU mortality
timeFrame: 28 days
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Bakirkoy Dr Sadi konuk Research and Training hospital
Study officials:
References: