Clinical trial NCT03281512: Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight
Official title: Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight in the China Health and Nutrition Survey (CHNS)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Morality
Diabetes
Hypertension
Overweight
Keywords: Saturated fatty acids
CHNS
Lead sponsor: Zhejiang University
Sponsor class: OTHER
Collaborators: name: National Institute of Health and Nutrition
First posted: 2017-09-13
Enrollment: 14383
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: CHNS is an ongoing, large-scale, household-based cohort starting in 1989. The survey used a multi-stage, random cluster process to draw a sample of 9 provinces and municipal cities, which take up about half of Chinese population.

Brief summary: The role of saturated fatty acids (SFAs) intake in the development of total death, cardiovascular diseases, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is scant.The investigators aim to use the data from the China Health and Nutrition Survey to assess the long-term association of SFAs intake with total mortality, diabetes, hypertension and overweight.

Detailed description: The role of saturated fatty acids (SFAs) intake in the development of total death, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is lacking.The investigators aim to utilize the data from the China Health and Nutrition Survey. The investigators will calculate the cumulative average intake of SFAs based on 3 consecutive 24-h dietary recalls in each round.Sex-specific Cox regression models will be used to estimate the relative risk.Results from our work will be used to provide epidemiological evidence for improving recommendation on SFAs intake for Chinese in dietary guidelines.

Eligibility criteria: Inclusion Criteria:

* Adults aged ≥20 with complete data on diet and follow-up time

Exclusion Criteria:

* Cardiovascular diseases
* Diabetes (for analyses of diabetes)
* Body mass index ≥ 24 kg/㎡ (for analyses of overweight)
* Hypertension (for analyses of hypertension)

Primary outcomes:
measure: Mortality
timeFrame: From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years
measure: Diabetes
timeFrame: From entry into the study (baseline: 1997-2009) until 2011
Secondary outcomes:
measure: Saturated fatty acids intake
timeFrame: From entry into the study (baseline: 1997-2009) until 2011
measure: Hypertension
timeFrame: From entry into the study (baseline: 1997-2009) until 2011
measure: Overweight
timeFrame: From entry into the study (baseline: 1997-2009) until 2011
Other outcomes:
Locations:
Study officials:
References:
citation: Zhuang P, Cheng L, Wang J, Zhang Y, Jiao J. Saturated Fatty Acid Intake Is Associated with Total Mortality in a Nationwide Cohort Study. J Nutr. 2019 Jan 1;149(1):68-77. doi: 10.1093/jn/nxy237.