louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02942108: Piezoelectric Vibrations and Tissue, Cellular and Molecular Mechanisms of Oral Wound Healing After Third Molar Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tooth, Impacted
Keywords: piezolectric surgery
conventional surgery
lower third molars
Lead sponsor: University of Belgrade
Sponsor class: OTHER
First posted: 2016-10-21
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The aim of this clinical trial is to investigate and compare the effect of piezoelectric surgery on tissue, cellular and molecular level of oral surgical wound healing and postoperative outcomes (pain, swelling, trismus) after lower third molar surgery in healthy patients


Eligibility criteria: Inclusion Criteria:

* bilaterally symmetrically impacted lower third molars

Exclusion Criteria:

* presence of intraoral infection
* chronic orofacial pain
* pregnancy/ lactation
* heavy tobacco smokers
* alcohol/ drug abuse
* allergic reaction to medicaments used

Primary outcomes:
measure: SOD activity in alveolar bone specimen
timeFrame: immediately after surgery
measure: VEGF levels in alveolar bone specimen
timeFrame: immediately after surgery
measure: MMP-9 level in alveolar bone specimen
timeFrame: immediately after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Belgrade
country: Serbia
facility: School of Dental Medicine, University of Belgrade
Study officials:
affiliation: School of Dental Medicine, University of Belgrade
name: Bozidar M Brkovic, DDS,PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: School of Dental Medicine, University of Belgrade
name: Milan V Vucetic, PhD student
role: PRINCIPAL_INVESTIGATOR
affiliation: School of Dental Medicine, University of Belgrade
name: Marija S Milic, DDS, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bailey E, Kashbour W, Shah N, Worthington HV, Renton TF, Coulthard P. Surgical techniques for the removal of mandibular wisdom teeth. Cochrane Database Syst Rev. 2020 Jul 26;7(7):CD004345. doi: 10.1002/14651858.CD004345.pub3.
Clinical trial NCT02236208: Effect of Folate Acid on Offspring Obesity
Official title: Mechanism of Folate Acid in Influencing Offspring Obesity During Pregnancy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pediatric Obesity
Lead sponsor: Nanjing Medical University
Sponsor class: OTHER
First posted: 2014-09-10
Enrollment: 20000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women with the early, mid and late pregnancy; Chilren

Brief summary: The purpose of this study is to observe the effect of lack or excess of folic acid in first, second and third trimester on child birth weight, fat content and the secretion of metabolism related hormone, and clinical follow-up their offspring obesity.


Eligibility criteria: Inclusion Criteria:

* Pregnancy women
* children
* Chinese

Exclusion Criteria:

-

Primary outcomes:
measure: The level of folate acid of pregnancy women at first trimester
timeFrame: 12 weeks of pregnancy
Secondary outcomes:
measure: The level of folate acid of pregnancy women at second trimester
timeFrame: 20-24 weeks of pregnancy
measure: The level of folate acid of pregnancy women at third trimester
timeFrame: 28-40 weeks of pregnancy
measure: The birth weight, fat content and metabolism related hormone secretion of their offspring
timeFrame: At birth
measure: The weight, fat content and metabolism related hormone secretion of their offspring at one year old
timeFrame: One years old
measure: The weight, fat content and metabolism related hormone secretion of their offspring at 3 years old
timeFrame: 3 years old
measure: The weight, fat content and metabolism related hormone secretion of their offspring at 5-7 years old
timeFrame: 5-7 years old
measure: The weight, fat content and the secretion of metabolism related hormone of offspring at 18 years old
timeFrame: 18 years old
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Nanjing Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University
state: Jiangsu
Study officials:
affiliation: Nanjing Medical University
name: Xirong Guo, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06552208: Biliary Obstruction of Neoplastic Origin Treated With Drainage. A Prognostic Study.
Official title: Elaboration of a Prognostic Score Based on Patients With Malignant Biliary Obstruction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Malignant Biliary Obstruction
Keywords: Prognostic score
Biliary drainage
30-day survival
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2024-08-13
Enrollment: 372
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The cohort will be selected from the general population of Brest, Finistère.

Brief summary: Inclusion of patients with biliary drainage for inoperable malignant biliary obstruction and analysis of clinico-biological parameters

Detailed description: All patients who had biliary drainage between April 1, 2014 and August 31, 2018 for inoperable malignant biliary obstruction will be included.

Clinical and biological baseline data will be recorded retrospectively. From the electronic medical records (M-Eva software), the following clinical data will be retrieved on the day of procedure: age, gender, body mass index (BMI), percentage of weight loss in the last three months, American Society of Anesthesiologists score (ASA) , Charlson score, Eastern Cooperative Oncology Group Performans Status (ECOG PS), comorbidities, cancer type, liver metastases, obstruction level, pre-procedural sepsis, type of procedure and type of stent.

Serum biological parameters will be recorded: hemoglobin, platelets, leukocytes, urea, creatinine, albumin, total bilirubin and prothrombin time, within 48 hours prior to the procedure.

The continuous variables of biological tests will be analyzed by ROC curves. The survival curves will be estimated using the Kaplan-Meier method and compared using the log-rank test. A prognostic index will be established from the variables independently associated with poor prognosis.

Eligibility criteria: Inclusion Criteria:

* Malignant Biliary obstruction : cholestasis (elevated bilirubin \> 40 µmol/L or alkaline phosphatase \> 1.5 time than the normal value) and dilation of biliary tract

Exclusion Criteria:

* Benign obstruction
* Post stent surgery
* First stent placed outside Brest University Hospital

Primary outcomes:
measure: Short-term survival after biliary drainage
timeFrame: 4 years and fifth months
Secondary outcomes:
measure: Prognostic score
timeFrame: 4 years and fifth months
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU de Brest
Study officials:
References:
Clinical trial NCT06115408: Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma
Official title: Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Uterine Leiomyoma
Keywords: Fibroids dienogest NAC
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2023-11-03
Enrollment: 40
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The study will be conducted on 40 women; they will be subdivided into 2equal groups .each group receive different intervention
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This 2 arm randomized clinical trial will assess the impact of Dienogest and N-Acetyl Cysteine on volume reduction of uterine leiomyoma

Detailed description: Group A women will receive Dienogest orally 2mg pills daily for 3 months .20 cases Group B women will receive NAC orally at a dose of 600 mg/day for 3 months ,20 cases

Eligibility criteria: Inclusion Criteria:

1. Age: 20-45 years.
2. Women with uterine leiomyoma (sub-mucous, sub-serous or intramural) based on transvaginal sonography criteria. Uterine fibroids most often appear as concentric, solid, hypoechoic masses. This appearance results from the prevailing muscle, which is observed at histologic examination. These solid masses absorb sound waves and therefore cause a variable amount of acoustic shadowing.
3. Regular menstruation: regular period interval from 21 to 35 days.

Exclusion Criteria:

1. Pregnant or menopausal women.
2. History of malignancies, metabolic, hematologic, cardiac, thromboembolism, diabetes, renal or hepatic diseases.
3. History of hormonal drug use or treatment for leiomyoma in the past 3 months.

Primary outcomes:
measure: leiomyoma size reduction
timeFrame: 3 months
Secondary outcomes:
measure: Dysmenorrhea
timeFrame: 3 Monthes
measure: heavy menstrual bleeding
timeFrame: 3 months
measure: blood loss
timeFrame: 3 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ainshams University
Study officials:
affiliation: Ain Shams University
name: Amr Mahmoud, lecturer
role: STUDY_CHAIR
affiliation: Ain Shams University
name: Ahmed mohamed mamdouh, assisstant professor
role: STUDY_CHAIR
References:
Clinical trial NCT03853408: Short Term Outcomes of Acute Cholecystitis Managed at a University Hospital
Official title: Short Term Outcomes of Acute Cholecystitis Managed at a University Hospital
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Cholecystitis
Keywords: Acute cholecystitis
Cholecystectomy
overweight
BMI
early
delayed
Lead sponsor: King Abdulaziz University
Sponsor class: OTHER
First posted: 2019-02-25
Enrollment: 88
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The data were collected retrospectively from the electronic medical records data system at KAUH. We included all adult patients who presented to the Emergency Department of KAUH with an acute cholecystitis between January 2010 and April 2018

Brief summary: The aim of this retrospective study was to assess the different outcomes of early (performed on the patient's first admission for acute cholecystitis) and delayed cholecystectomy (done on a second admission) at King Abdulaziz University Hospital in Jeddah, Saudi Arabia.

Detailed description: This study was conducted retrospectively through reviewing patients medical records

Eligibility criteria: Inclusion Criteria:

Male and female patients who presented to the Emergency Department of KAUH with an acute cholecystitis

Exclusion Criteria:

* Patients with no acute cholecystitis

Primary outcomes:
measure: Type of surgery
timeFrame: Intraoperative (during surgery) - surgery takes an hour on an average
measure: Blood Transfusion need
timeFrame: Intraoperative (during surgery) - surgery takes an hour on an average
measure: ICU admission:
timeFrame: Post operation "after surgery" immediately
measure: Duration of Surgery
timeFrame: minutes "intraoperative" (surgery takes 1 hour on an average)
measure: Time to operation room (hours)
timeFrame: hours pre surgery
measure: Length of stay after surgery
timeFrame: Days ( usually 2 days on an average )
Secondary outcomes:
Other outcomes:
Locations:
city: Jeddah
country: Saudi Arabia
facility: King Abulaziz University
state: Makkah Region
Study officials:
References:
Clinical trial NCT05534308: Effect of Intraoperative Taping on the Control of Edema Resulting From Stripping
Official title: Effect of Intraoperative Taping on the Control of Edema Resulting From Stripping
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Edema
Varices; Cord
Keywords: Functional Bandages
Edema
Ultrasound
Varices
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2022-09-09
Enrollment: 60
Sex: ALL
Minimum age (years): 25
Maximum age (years): 59
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to evaluate the effects of the Contensive Taping technique on the control of edema of patients submitted to Phleboextraction Surgery including Saphenectomy.

Detailed description: Edema is a common complication after stripping surgery, so measures that can help the resolution of the condition are important for the recovery in the post operative. The aim of the study is to evaluate the effects of the Contensive Taping technique on the control of edema of patients submitted to phleboextraction surgery including saphenectomy. Therefore, 60 patients of both sexes will be invited to participate in the study, undergoing saphenectomy surgery, divided into two homogeneous groups, determined by the sample calculation. The intervention group (IG) will be composed of patients undergoing phleboextraction with saphenectomy and intervention with contensive taping, in intraoperative period associated with compression with elastic stockings. The control group (CG) will be composed of patients undergoing the same surgical procedure, and standard treatment consisting only of compression by elastic stockings. The procedures for evaluation will be applied before and after seven days of therapeutic intervention. For data analysis, the normality test will be performed and distribution, in addition to a suitable statistical test for the appropriate intra and intergroups, with a significance level of 5%.

Eligibility criteria: Inclusion Criteria:

* young adults, aged from 25 to 59 years old, submitted to stripping and saphenectomy.

Exclusion Criteria:

* allergies
* skin lesions
* ulcers.

Primary outcomes:
measure: Edema
timeFrame: 7 days
measure: Dieletric constant
timeFrame: 7 days
Secondary outcomes:
measure: Elasticity
timeFrame: 7 days
measure: Pain after surgery
timeFrame: 7 days
measure: Functionality of Lower Limbs
timeFrame: 7 days
measure: Tissue stiffness
timeFrame: 7 days
Other outcomes:
Locations:
city: Ribeirão Preto
country: Brazil
facility: Medical School of Ribeirão Preto
state: São Paulo
Study officials:
affiliation: University of Sao Paulo
name: Elaine CO Guirro, PhD
role: STUDY_DIRECTOR
References:
citation: Tatli U, Benlidayi IC, Salimov F, Guzel R. Effectiveness of kinesio taping on postoperative morbidity after impacted mandibular third molar surgery: a prospective, randomized, placebo-controlled clinical study. J Appl Oral Sci. 2020;28:e20200159. doi: 10.1590/1678-7757-2020-0159. Epub 2020 Jul 13.
Clinical trial NCT06456008: Prospective Registery of Smell/Taste Clinic Ear/Nose/Throat
Official title: Prospective Registry of Outcome and Correlates of Chemosensory Dysfunction at the Smell & Taste Clinic of UZ Leuven
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Olfactory Disorder
Taste Disorders
Smell Dysfunction
Smell Disorder
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2024-06-13
Enrollment: 500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients consulting for chemosensory dysfunction

Brief summary: Smell/taste disorders are common conditions with a significant impact on quality of life. In September 2021, a specific consultation for patients with smell and taste disorders was initiated at the ENT-HNS (ear, nose, and throat, head and neck surgery) department of UZ Leuven, partly in light of post-COVID-19 related smell disorders.

With this observational ambidirectional study, we aim to better map smell/taste disorders in the Belgian/Flemish population. Using standard-of-care diagnostic tests and structured questionnaires, we strive to gain more insight into the severity, impact, and progression/prognosis of smell/taste disorders.


Eligibility criteria: The psychophysical testing as well as the questionnaires require a cooperative participant who can understand and follow instructions and communicate their choices. Informed consent is necessary upon participation for prospective registry. There are no exclusion criteria related to sex, gender, or ethnicity. There are no exclusion criteria related to medical history or prior treatments. This study conveys no additional risks for care groups such as pregnant women, or elderly

Primary outcomes:
measure: Chemosensory function
timeFrame: Observational up to 5 years follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: UZ/KU Leuven
state: Vlaams-Brabant
Study officials:
References:
Clinical trial NCT06528808: Simple Simulation Based Breast Cancer Awareness Training
Official title: The Effect of Simple Simulation-Based Breast Cancer Awareness Training on Women's Breast Cancer Knowledge and Fear Levels
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Breast Cancer Awareness Training
Keywords: Simulation Based
Breast Cancer Awareness
Lead sponsor: Saglik Bilimleri Universitesi
Sponsor class: OTHER
First posted: 2024-07-30
Enrollment: 80
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Quasi-experimental randomized controlled trial
Primary purpose: OTHER

Brief summary: It was planned to determine the effect of simple simulation-based breast cancer awareness training on women's breast cancer knowledge and fear levels. The research population will consist of female service personnel working in institutions within the University of Health Sciences (SBÜ) (N: 670). In order to determine the sample size in this research, which was planned as a quasi-experimental with a pre- and post-test design and a control group; The data showed a normal distribution, the standard deviation of the population was estimated to be 1, and the effect size (difference) was estimated to be 0.8. It was calculated that if two independent n₁=40, n₂=40 samples were taken for the analysis to be carried out, at a 5% significance level, the maximum power value of the research would be 0.942182. Both groups will be given theoretical training about breast cancer awareness, and women in the intervention group will practice breast cancer awareness with a simple valid simulator. All groups will be informed before the applications. The training content will be supported by distributing a 5-page training booklet created from breast health and cancer awareness content to the participants. "Comprehensive Breast Cancer Knowledge Test", "Breast Cancer Fear Scale" and "Breast Cancer Awareness Scale" will be applied as a pre-test after the information.


Eligibility criteria: Inclusion Criteria:

* Volunteering to participate in the research.
* To work as female service personnel in institutions within the University of Health Sciences.

Exclusion Criteria:

- Not participating in all applications of simulation teaching.

Primary outcomes:
measure: Introductory Information Form
timeFrame: 10 minutes
measure: Comprehensive Breast Cancer Knowledge Test
timeFrame: 10 minutes
measure: Breast Cancer Fear Scale
timeFrame: 10 minutes
measure: Breast Cancer Awareness Scale
timeFrame: 10 minutes
Secondary outcomes:
measure: Comprehensive Breast Cancer Knowledge Test
timeFrame: 10 minutes
measure: Breast Cancer Fear Scale
timeFrame: 10 minutes
measure: Breast Cancer Awareness Scale
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: University of Health Sciences
Study officials:
References:
Clinical trial NCT02214108: Effect of Physical Activity Through Interactive Video Games in Overweight Children
Official title: Effect of Physical Activity Trough Interactive Video Games in Overweight, Randomized, Controlled Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Obesity
Overweight
Keywords: BMI
Obesity
overweight
child
Physical activity
Lead sponsor: Centro Pediatrico Albina de Patino
Sponsor class: OTHER
Collaborators: name: University of Chile
First posted: 2014-08-12
Enrollment: 60
Sex: ALL
Minimum age (years): 5
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the effect of interactive video game in management of overweight in children. The investigators will evaluate the effect of product versus standard physical activity.

Detailed description: Background. Child Overweight and obesity are a world public health problem, in low income countries is more. One difficulty in the management is the poor adherence to physical activity, some studies show that active video games could improve this.

Objective: Establish the effect of the introduction of active video game (Nintendo Wii) on fitness, anthropometry and adherence to treatment, as part of an intervention program for the management of childhood obesity in children over 5 years of age with obesity Methodology: A clinical trial, randomized and controlled. children between 5-10 years with a diagnosis of overweight or obese, were divided into two groups. (Wii group), received 3 weekly sessions of one hour of physical activity by an active video game, the other group (control group) received 3 weekly sessions of one hour of physical activity by static exercises.

Eligibility criteria: Inclusion Criteria:

* children aged 5-10 years with a diagnosis of overweight or obese (according to WHO criteria)

Exclusion Criteria:

* overweight or obese due other disease.

Primary outcomes:
measure: Change in Body Mass Index
timeFrame: one month
Secondary outcomes:
measure: change in weight
timeFrame: one month
measure: change in physical endurance
timeFrame: one month
measure: variations in serum lipids
timeFrame: 1 month
Other outcomes:
Locations:
city: Cochabamba
country: Bolivia
facility: Pediatric Center Albina Patino
Study officials:
affiliation: Centro de Pediatria Albina Patino
name: Giuseppe Esteban Grandy Aranda, MSc
role: STUDY_DIRECTOR
affiliation: Centro de Pediatria Albina Patino
name: Alicia Ribero Nogales, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Institute of Nutrition and Technology of Food.
name: Gerardo Weisstaub, MSc
role: STUDY_CHAIR
References: