louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05186376: Accuracy of Maxillary Repositioning With bi or Tripartite Disjonction by Virtual Planning in Orthognathic Surgery Using Patient-specific Titanium Plates
Official title: Accuracy of Maxillary Repositioning With bi or Tripartite Disjonction by Virtual Planning in Orthognathic Surgery Using Patient-specific Titanium Plates : a Case Series
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Occlusal Trauma
Lead sponsor: Centre Hospitalier Universitaire de Nice
Sponsor class: OTHER
First posted: 2022-01-11
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 22 patients, who underwent bimaxillar osteotomy with maxillar segmentation, in Nice from September 2017 to July 2021, operated by Charles SAVOLDELLI, using patient-specific implants

Brief summary: The aim of this study was to assess the accuracy of computer-aided orthognathic surgery and patient specific titanium plates for maxillar osteotomy with bi or tripartite disjonction in 22 patients who underwent bimaxillar osteotomy for occlusal trouble.


Eligibility criteria: Inclusion Criteria:

- bimaxillar osteotomy with maxillar segmentation and full imageries .

Exclusion Criteria:

None

Primary outcomes:
measure: accuracy of patient-specific surgical guides and plates in maxillary repositioning with bi or tri-partite disjonction
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Nice
country: France
facility: Nice University Hospital - IUFC
Study officials:
References:
Clinical trial NCT04639427: Benefits of Using a Transparent Visor to Replace the Face Mask in Speech Therapy Rehabilitation of Oral-Linguo-Facial Praxies in the Context of COVID-19: a Series of Cases
Official title: Benefits of Using a Transparent Visor to Replace the Face Mask in Speech Therapy Rehabilitation of Oral-Linguo-Facial Praxies in the Context of COVID-19: a Series of Cases
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Oral-Linguo-Facial Praxies
Covid19
Keywords: Oral-Linguo-Facial praxies
Covid19
speech therapy rehabilitation
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2020-11-20
Enrollment: 4
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 4 patients hospitalized in the adult neurological Post Intensive Care Rehabilitation Unit (PICRU - SRPR) of Raymond Poincaré hospital.

Brief summary: The primary objective of the study is to compare the effectiveness of the use of a transparent covering visor with that of the face mask, with or without the use of video sequences, for speech therapy rehabilitation of oral-linguo-facial praxies in the context of the COVID 19 epidemic.

Detailed description: Statistic analysis: single case experimental design (SCED) method.

Eligibility criteria: Inclusion Criteria:

* Aged \>= 18 years;
* Hospitalization for more than 2 weeks prior to enrollment in the adult post intensive care rehabilitation care unit (PICRU) of Raymond Poincaré hospital in Garches;
* With oral-linguo-facial praxis disorders whatever the cause;
* Has been informed and not in opposition to participation of the study.

Exclusion Criteria:

* Patient with fever or any suspect symptom of a SARS-CoV2 infection;
* Planned discharge of hospital in 2 weeks;
* Patient with cognitive, phasic or vigilance disorders preventing to understand the study;
* Under guardianship or curator;
* Patient Under french AME scheme.

Primary outcomes:
measure: Oral-Linguo-Facial Motricity Test
timeFrame: throughtout of the study, an average of 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Garches
country: France
facility: Unité de Soins de Rééducation Post Réanimation, Service de Médecine Physique et de Réadaptation, Hôpital Raymond Poincaré, APHP
Study officials:
affiliation: Unité de Soins de Rééducation Post Réanimation, Service de Médecine Physique et de Réadaptation, Hôpital Raymond Poincaré, APHP
name: Julie PAQUEREAU, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04908527: Effect of Walking to the Operating Room on Preoperative Anxiety
Official title: Effect of Walking to the Operating Room on Preoperative Anxiety in Patients Scheduled for Outpatient Laser Therapy for Venous Insufficiency: A Monocentric Randomized Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vein, Varicose
Lead sponsor: University of Liege
Sponsor class: OTHER
First posted: 2021-06-01
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The operating room environment can be a source of anxiety for the patient, including in the context of outpatient surgery for which anxiolytic medication is rarely used. This anxiety-induced effect can be reinforced by the patient's lack of active participation.

Some studies have already shown the feasibility of patient walking to the operating room (OR) and advantages this approach(Kojima and Ina 2002; Lack 2016; Nagraj et al. 2006).

Moreover, recovery room complications and pain have also been shown to be greater after varicose vein surgery in patients with significant preoperative anxiety (Scavee et al. 2016).

Therefore, the investigators decided to test the effects of walking to OR for patients admitted for outpatient surgery for varicose vein surgery.


Eligibility criteria: Inclusion Criteria:

* Outpatient minimal invasive laser therapy for venous insufficiency

Exclusion Criteria:

* Inpatient surgery
* Invasive surgery
* Need for premedication
* Use of walking aid
* Non-French speaking patient
* Patient refusal

Primary outcomes:
measure: Level of anxiety
timeFrame: Preoperatively in the room
measure: Level of anxiety
timeFrame: Preoperatively in the room
measure: Level of anxiety
timeFrame: Preoperatively in front of OR
measure: Level of anxiety
timeFrame: Before departure of the outpatient unit
Secondary outcomes:
measure: Level of pain
timeFrame: Within 1 hour after admission in the Post Anesthesia Care Unit after surgery
measure: Level of pain
timeFrame: Before departure of outpatient unit
measure: Level of pain
timeFrame: At Day 1
measure: Presence of nausea and vomiting
timeFrame: During the stay in the Post Anesthesia Care Unit after surgery assessed up to 12h
measure: Presence of nausea and vomiting
timeFrame: During the stay in the outpatient unit after surgery assessed up to 12h
measure: Presence of nausea and vomiting
timeFrame: at Day 1
Other outcomes:
Locations:
city: Liège
country: Belgium
facility: Centre hospitalier universitaire de Liege
Study officials:
affiliation: Centre Hospitalier Universitaire de Liege
name: Claude Hallet, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01576627: Zinc Absorption From Zinc Citrate, Zinc Gluconate and Zinc Oxide
Official title: Zinc Absorption From Zinc Supplements Comparing Zinc Citrate to Zinc Gluconate and Zinc Oxide in Young Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: Swiss Federal Institute of Technology
Sponsor class: OTHER
Collaborators: name: University of Zurich
First posted: 2012-04-12
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: The goal of this trial is to evaluate zinc citrate, a zinc compound with promising sensory properties and a high zinc content, as an alternative zinc compound to be used for supplementation or food fortification. The bioavailability of zinc citrate given as a supplement to young Swiss adults will be assessed and compared to the bioavailability of the commonly used zinc compounds zinc gluconate and zinc oxide.


Eligibility criteria: Inclusion Criteria:

* Male or female of 18 to 45 years old
* Body Mass Index in the range of 19 to 25
* No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study

Exclusion Criteria:

* Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)
* Long-term medication during the whole study (except for contraceptives)
* Vegans
* Pregnancy
* Lactation
* Intention to become pregnant during the course of the study
* Lack of safe contraception
* Consumption of mineral and vitamin supplements within 2 weeks prior to 1st test supplement administration
* Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study

Primary outcomes:
measure: Fractional absorption of zinc
timeFrame: 61 days
Secondary outcomes:
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: ETH Zurich
Study officials:
References:
citation: Wegmuller R, Tay F, Zeder C, Brnic M, Hurrell RF. Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. J Nutr. 2014 Feb;144(2):132-6. doi: 10.3945/jn.113.181487. Epub 2013 Nov 20.
Clinical trial NCT05783427: An Evaluation of a Liberal Hydration Regimen Before Elective Caesarean Section Using Beside Gastric Ultrasound
Official title: An Evaluation of a Liberal Hydration Regimen Before Elective Caesarean Section Using
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aspiration; Gastric Contents, Anesthesia
Lead sponsor: Coombe Women and Infants University Hospital
Sponsor class: OTHER
First posted: 2023-03-24
Enrollment: 55
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: women who are undergoing a planned elective caesarean delivery

Brief summary: The aim of this study is to compare the residual gastric volumes in non-labouring parturients prior to elective Caesarean delivery when fully fasted as per European Society of Anaesthesia pre-operative fasting guidelines against the 'Sip Til Send' fasting guideline via a paired cohort study. The primary hypothesis is that 'Sip Til Send' would be non-inferior to standard fasting at minimising the residual gastric volume prior to surgery.


Eligibility criteria: Inclusion Criteria:

* planned caesarean delivery under regional anaesthesia
* adhered to national fasting guidance of 6 hrs for food and 2 hours for clear fluids

Exclusion Criteria:

* age less than 18
* inability to understand English

Primary outcomes:
measure: gastric volume
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Dublin
country: Ireland
facility: Coombe Women's Hospital
Study officials:
affiliation: Coombe Womens Hospital
name: Ryan Howle
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04339127: Autoimmune Encephalitis With Anti-NMDA Receptor Antibodies Following Herpetic Encephalitis
Official title: Study of 12 Cases of Autoimmune Encephalitis With Anti-NMDA Receptor Antibodies Following Herpetic Encephalitis and Review of the Literature
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Autoimmune Encephalitis
Anti NMDA Receptor Encephalitis
Herpetic Encephalitis
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2020-04-09
Enrollment: 12
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 12 patients diagnosed between January 2014 and January 2020

Brief summary: Herpes Simplex Virus encephalitis is the most common infectious encephalitis, with an estimated annual incidence of 1 / 250,000 to 1 / 500,000 in industrialized countries. Despite a widely used antiviral treatment, the prognosis remains poor with a mortality of 5 to 20% and a considerable morbidity rate.

One of the contributing factors of bad prognosis is the development of encephalitis mediated by autoantibodies, most often directed against NMDA receptors, in the weeks following viral encephalitis.

The description of this pathology is recent, the pathophysiology of this process remains poorly understood, and the management of these patients is not yet codified.


Eligibility criteria: Inclusion Criteria:

* Clinical autoimmune encephalitis with anti-NMDA antibodies and documented by CBA in the CSF
* After a herpetic encephalitis documented by a positive viral PCR for HSV in the CSF
* Without age limit

Exclusion Criteria- No respect of inclusion criteria

Primary outcomes:
measure: Details of clinical, biological, imaging, therapeutic characteristics and patient's evolution.
timeFrame: at 6 and 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Bron
country: France
facility: Hospice Civils de Lyon
Study officials:
affiliation: National Reference Center of autoimmune encephalitis
name: Jérôme Honnorat
role: STUDY_DIRECTOR
References:
Clinical trial NCT00973427: DNA Chip Based Prognosis of Lung Cancer
Official title: DNA Chip Based Prognosis of Lung Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Keywords: NSCLC
Lead sponsor: Medical Prognosis Institute A/S
Sponsor class: INDUSTRY
First posted: 2009-09-09
Enrollment: 144
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population consist of subjects being examined for NSCLC at Roswell Park Cancer Institute (US), University of Alabama (US), Copenhagen University (DK), Odense University Hospital (DK) and Aarhus University Hospital (DK)

Brief summary: The purpose of the study is to determine whether a DNA chip, designed by Medical Prognosis Institute (MPI), can provide an accurate prognosis for survival of NSCLC (adeno-, squamous and large cell lung cancer).


Eligibility criteria: Inclusion Criteria:

1. A histological diagnosis of primary NSCLC stage Ia
2. Surgical removal of the tumor
3. Age between 18 and 75 years
4. Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

1. A primary NSCLC stage Ia diagnosis that is changed to not primary NSCLC or NSCLC stage Ib-IV after surgery.
2. Adjuvant treatment with chemotherapy.
3. Prior history of cancer in the past 5 years or breast cancer at any time.
4. Life expectancy less than 3 years in the opinion of the investigator due to concurrent illnesses.

Primary outcomes:
measure: Disease-related survival
timeFrame: 5 years
Secondary outcomes:
measure: Time to progression
timeFrame: 5 years
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama
state: Alabama
city: Buffalo
country: United States
facility: Roswell Park Cancer Institute
state: New York
city: Aarhus
country: Denmark
facility: Aarhus University Hospital
city: Copenhagen
country: Denmark
facility: University of Copenhagen
city: Odense
country: Denmark
facility: Odense University Hospital
Study officials:
affiliation: Medical Prognosis Institute (MPI)
name: Steen Knudsen, PhD
role: STUDY_CHAIR
affiliation: Dept. Oncology, Copenhagen University
name: Jens B. Sørensen, MD
role: STUDY_DIRECTOR
affiliation: University of Copenhagen
name: Jesper Ravn, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01542827: Acute Effect of Topical Menthol on Neck Pain
Official title: Danish: Integreret Motion på Arbejdspladsen (IRMA) English: Implementation of Exercise at the Workplace
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Musculoskeletal Disorders
Keywords: neck pain
menthol
Lead sponsor: National Research Centre for the Working Environment, Denmark
Sponsor class: OTHER_GOV
Collaborators: name: Marquette University
name: Sport and Spine Rehab Clinical Research Foundation
First posted: 2012-03-02
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 67
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Topical menthol gels are classified 'topical analgesics' and are used to relieve aching and tenderness of muscles and joints. However, double-blind randomized controlled trials are lacking. Here the investigators examine - in a double-blind randomized controlled cross-over trial - the acute effect of topical menthol (Biofreeze) and placebo (gel with a menthol scent) on neck pain.


Eligibility criteria: Inclusion Criteria:

* more than 30 days with neck pain during the last year
* frequent pain or discomfort, defined as at least 3 days per week
* pain intensity at least 4 on a scale of 0-10
* working at least 30 hours per week

Exclusion Criteria:

* blood pressure above 160/100 mmHg
* pregnancy
* life-threatening disease

Primary outcomes:
measure: Neck pain intensity (scale 0-10)
timeFrame: before and 20 min after application
Secondary outcomes:
measure: Pressure pain threshold (PPT)
timeFrame: before and 20 min after application
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: National Research Centre for the Working Environment
Study officials:
affiliation: Professor
name: Lars L Andersen, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04284527: The Assessment of Physiotherapy Practice Validation as a Measure in Physiotherapy Student
Official title: Validity and Reliability of the Assessment of Physiotherapy Practice Validation as a Measure in Physiotherapy Student
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Assessment, Self
Clinical Performance
Keywords: physiotherapy
student
assesment tool
Lead sponsor: Universidad Católica San Antonio de Murcia
Sponsor class: OTHER
First posted: 2020-02-25
Enrollment: 300
Sex: ALL
Minimum age (years): 19
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Students of the specific methods of intervention in physiotherapy course of Catholic University of Murcia, Spain

Brief summary: The objective of this study is to determine the reliability and validity of the assesment of physiotherapy practice (APP) in physiotherapy students. Concretely the study aims to verify if the APP created by the professors of specific methods of intervention in physiotherapy course is a reliable tool to evaluate student performance of history taking and physical examination in the same course.

Detailed description: Before evaluating this scale, the investigators want to verify the effectiveness of this online practice in the COVID period by processing the Mind Genomics questionnaire.

After the fist online results of this practice evaluation the investigators have to interpret and evaluate the APP.

Eligibility criteria: Inclusion Criteria:

* students of specific methods of intervention in physiotherapy course
* students of Catholic University of Murcia, Spain
* with a minimum of 19 years old
* in the second course of physiotherapy

Exclusion Criteria:

* other courses participants
* professors
* segretary

Primary outcomes:
measure: Assessment of Physiotherapy Practice (APP)
timeFrame: 10 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Murcia
country: Spain
facility: Universidad Católica de Murcia
Study officials:
affiliation: UCAM Universidad Catolica de Murcia
name: Carolina Vasques Villa, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00989027: Impact of Uterotonic Agents on Isolated Human Myometrium
Official title: Impact of Uterotonic Agents on Isolated Human Myometrium
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postpartum Hemorrhage
Keywords: Uterine contraction
Dose-response
Oxytocin pre-treatment
Lead sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Sponsor class: OTHER
First posted: 2009-10-02
Enrollment: 56
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the ability of a sample of uterine muscle tissue to contract in the presence of various drugs. The drugs studied are typically used to contract the uterus when a pregnant patient continues to bleed after delivery. Amongst the uterotonic drugs (used to contract the uterus), namely oxytocin, ergonovine and carboprost, the most effective one to use is not known.

The investigators will be testing uterine muscle samples in the presence of these drugs at various concentrations, to see what their contractility measures over time, as compared with a control sample, in which no drugs will be applied.

Detailed description: Postpartum hemorrhage (PPH) is a major cause of maternal mortality and morbidity. In 80% cases of PPH, the primary cause is failure of the uterus to contract after delivery of the baby, which then requires further treatment of the mother with uterotonic drugs (drugs used to contract uterus and thus prevent bleeding).

Patients participating in this study will be asked to donate a very small sample of uterine tissue during Cesarean section, which will be tested for the ability to contract after treatment with various uterotonic drugs (oxytocin, ergonovine and carboprost) in the laboratory. This information will help us know the effect of these drugs by comparing the contractile capability of the uterine tissue.

Eligibility criteria: Inclusion Criteria:

* Gestational age 37-41 weeks
* Non-laboring patients, not exposed to exogenous oxytocin
* Patients requiring primary Cesarean section
* Cesarean section under spinal anesthesia

Exclusion Criteria:

* Patients who require general anesthesia
* Patient who had previous uterine surgery or Cesarean section
* Patients with placental anomalies
* Emergency Cesarean section in labor
* Patients with bleeding disorders

Primary outcomes:
measure: Amplitude of contraction
timeFrame: 6-8 hours
Secondary outcomes:
measure: Integrated area under response curve (AUC)
timeFrame: 6-8 hours
measure: Basal tone
timeFrame: 6-8 hours
measure: Frequency of contraction
timeFrame: 6-8 hours
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Mount Sinai Hospital
state: Ontario
Study officials:
affiliation: MOUNT SINAI HOSPITAL
name: Mrinalini Balki, MD
role: PRINCIPAL_INVESTIGATOR
References: