Clinical trial NCT05275062: Clinical Trial to Evaluate the Safety and Efficacy of IM92 CAR-T Cells Therapy in Patients With Advanced Gastric or Pancreatic Adenocarcinoma
Official title: Clinical Trial to Evaluate the Safety and Efficacy of IM92 CAR-T Cells Therapy in Patients With Advanced Gastric or Pancreatic Adenocarcinoma
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: Advanced Solid Tumors
Gastric Cancer
Esophagogastric Junction Cancer
Pancreatic Cancer
Lead sponsor: Beijing Immunochina Medical Science & Technology Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2022-03-11
Enrollment: 6
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a open-label, single center to determine the efficacy and safety of IM92 CAR-T cells in Patients With advanced gastric/esophagogastric combination adenocarcinoma that has failed at least second-line therapy and advanced pancreatic cancer that has failed at least first-line therapy.


Eligibility criteria: Inclusion Criteria:

* Aged 18 to 75 years, either sex;
* Patients with pathologically diagnosed advanced gastric/ gastroesophageal junction adenocarcinoma who have failed second-line treatment at least; or patients with pathologically diagnosed advanced pancreatic cancer who have failed first-line treatment at least;
* Tumor tissue samples were positive for CLDN18.2 IHC staining(≥+，≥10%);
* Estimated life expectancy \>12 weeks;
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1;
* Women of childbearing age who had a negative blood pregnancy test before the start of the trial and agreed to take effective contraceptive measures during the trial period until the last follow-up; male subjects with fertility partners agreed to take effective contraceptive measures during the trial period until the last follow-up;
* Adequate organ function;
* Adequate vascular access for leukapheresis procedure;
* Volunteer to participate in this trial and sign on the informed consent.

Exclusion Criteria:

* Patients have brain metastasis；
* Patients with a history of organ transplantation or awaiting organ transplantation;
* The side effects caused by the previous treatment of the subjects did not return to CTCAE ≤1; other tolerable events determined by investigator;
* There is a large amount of serous effusion that cannot be controlled by treatment (such as pleural effusion, peritoneal effusion and pericardial effusion);
* History of autoimmune disease (eg Crohn's disease, rheumatoid arthritis, systemic lupus) within the last 2 years;
* Presence of acute or chronic graft-versus-host disease (GVHD);
* Use prohibited drugs or treatments within a specified period of time before cell collection；
* History or presence of CNS disorder, such as epilepsy, epileptic seizures, cerebrovascular disease (ischemia / hemorrhage / cerebral infarction), brain edema, reversible posterior white matter encephalopathy, paralysis, aphasia, stroke, severe brain injury, dementia, Parkinson's disease, cerebellar disease, cerebral organic syndrome or mental disease;
* Chronic or active infections requiring systemic treatment, and a history of symptomatic viral infection that has not been completely cured；
* Live vaccine received within 6 weeks before the start of screening;
* Cardiac dysfunction includes: long QTc syndrome or QTc interval \> 480 MS; Complete left bundle branch block, grade II / III atrioventricular block; Serious and uncontrolled arrhythmias requiring drug treatment; A history of chronic congestive heart failure with NYHA ≥ 3, and the cardiac ejection fraction was less than 50% within 6 months before screening; Cardiac valvular disease with CTC AE ≥ 3; Myocardial infarction, cardiac angioplasty or stenting, unstable angina pectoris, history of severe pericardial disease or other clinically significant heart diseases within 6 months before screening;
* Patients requiring anticoagulant therapy;
* Patients requiring continuous anti-platelet therapy;
* History of symptomatic deep vein thrombosis or pulmonary embolism within 6 months of enrollment;
* A history of other malignancies with a higher risk of recurrence was assessed by the investigator;
* Presence of fungal, bacterial, viral, or other infection that is uncontrolled or requiring intravenous (IV) antimicrobials for management. Simple urinary tract infection (UTI) and bacterial pharyngitis are permitted if the investigator evaluates that it can be controlled by treatment, they can be included in the group;
* Patients at high risk of hemorrhage or perforation;
* Patients were enrolled in another clinical study at the same time, unless it was an observational (non intervention) clinical study;
* In the investigator's judgment, the subject is unlikely to complete all protocol-required study visits or procedures, including follow-up visits, or comply with the study requirements for participation.

Primary outcomes:
measure: Incidence of adverse events (AEs)
timeFrame: Up to 28 days after CAR-T cell infusion
Secondary outcomes:
measure: Objective response rate (ORR)
timeFrame: Up to 24 weeks after CAR-T cell infusion
measure: Disease Control Rate（DCR）
timeFrame: Up to 24 weeks after CAR-T cell infusion
measure: Progression-free survival (PFS)
timeFrame: Up to 24 weeks after CAR-T cell infusion
measure: Overall survival (OS)
timeFrame: Up to 24 weeks after CAR-T cell infusion
measure: Persistence of CAR-T cells (cell counts and cell percentage in peripheral blood)
timeFrame: Up to 24 weeks after CAR-T cell infusion
measure: Response rate of tumor markers (CEA, CA19-9) before and after CAR-T cells infusion
timeFrame: Up to 24 weeks after CAR-T cell infusion
measure: Anti-therapeutic IM92 CAR-T cells antibody
timeFrame: Up to 24 weeks after IM92 CAR-T cell infusion
Other outcomes:
Locations:
city: Beijing
country: China
facility: Chinese PLA GENERAL HOSPITAL
state: Beijing
Study officials:
affiliation: Chinese PLA General Hospital
name: Jianming Xu, M.D.
role: PRINCIPAL_INVESTIGATOR
References: