louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01154608: Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pancreatitis
Keywords: Protein absorption in pancreatitis
Protein metabolism in pancreatitis
Lead sponsor: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Sponsor class: OTHER
Collaborators: name: National Research Agency, France
name: Solvay Pharmaceuticals
First posted: 2010-07-01
Enrollment: 11
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption. We aimed to investigate this question and assess the enzyme substitution efficiency using a sensitive method.


Eligibility criteria: Inclusion Criteria:

* Chronic pancreatitis
* Pancreatic insufficiency
* Enzyme therapy treatment

Exclusion Criteria:

* Hepatic failure
* Pregnancy
* Positive serology to HIV, HCV, AGHbS, gastro-intestinal disease

Primary outcomes:
measure: transfer of dietary nitrogen to metabolic pools
Secondary outcomes:
Other outcomes:
Locations:
city: Bobigny
country: France
facility: Centre de Recherche sur Volontaires
Study officials:
References:
Clinical trial NCT03096808: Adaptive Radiotherapy for Head and Neck Cancer
Official title: A Prospective Non-Inferiority Trial of the Use of Adaptive Radiotherapy for Head and Neck Cancer Undergoing Radiation Therapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Head and Neck Cancer
Paranasal Sinus Cancer
Oropharynx Cancer
Oral Cavity Cancer
Nasopharynx Cancer
Larynx Cancer
Hypopharynx Cancer
Keywords: adaptive radiotherapy
ART
intensity modulated radiation therapy
IMRT
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2017-03-30
Enrollment: 64
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to demonstrate that adaptive radiotherapy (ART) in head and neck cancer patients are comparable to historical controls in head and neck patients undergoing standard intensity-modulated radiation therapy (IMRT) without ART.


Eligibility criteria: Inclusion Criteria:

* Participants with pathologically confirmed cancers of paranasal sinuses, oropharynx, oral cavity, nasopharynx, larynx, hypopharynx, and unknown primary and will receive definitive radiation therapy with or without chemotherapy.
* Karnofsky performance status \>= 70%
* Women of childbearing potential need to have a negative serum pregnancy test at the time of therapy
* Participants must have the ability to understand and the willingness to sign a written consent form

Exclusion Criteria:

* Female participants who are pregnant or breast feeding
* Participants who are not able to comply with study and/or follow up procedures
* Participants who have received induction chemotherapy before radiation treatment
* Participants who had prior head and neck radiation therapy
* Participants who are enrolled in a national/international cooperative group trials
* Patients with metastatic disease

Primary outcomes:
measure: Number of patients with locoregional recurrence-free interval
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Basking Ridge
country: United States
facility: Memorial Sloan Kettering Basking Ridge
state: New Jersey
city: Middletown
country: United States
facility: Memorial Sloan Kettering Monmouth
state: New Jersey
city: Montvale
country: United States
facility: Memorial Sloan Kettering Bergen
state: New Jersey
city: Commack
country: United States
facility: Memorial Sloan Kettering Commack
state: New York
city: Harrison
country: United States
facility: Memoral Sloan Kettering Westchester
state: New York
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
city: Rockville Centre
country: United States
facility: Memorial Sloan Kettering Rockville Centre
state: New York
city: Uniondale
country: United States
facility: Memorial Sloan Kettering Nassau
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: C. Jillian Tsai, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05191238: Intrauterine Device (IUD) Self Removal
Official title: Patients Pull the Strings: A Pilot Study of IUD Self-Removal Simulation
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: IUD Removal
Keywords: Self removal of IUD
Educational video
Simulation
Patient education
Intrauterine device
Contraception
Lead sponsor: Boston Medical Center
Sponsor class: OTHER
Collaborators: name: Society of Family Planning
First posted: 2022-01-13
Enrollment: 37
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This pilot research study will teach patients how to self-remove intrauterine contraceptive device (IUD) through an educational video and simulation and evaluate patient perspectives and experiences related to IUD self-removal with two surveys. Patients will be recruited for this study at the time of presentation to the office for IUD removal. After consenting to the procedure, participants will complete a pre-intervention survey, watch a video explaining how to self-remove the IUD, and use two models to simulate IUD removal. After completion of using the models to practice IUD removal, participants will complete a second short survey. The participant will then be given the option of attempting self-removal and be given time to attempt the removal. If the participant elects to have the provider remove their IUD, the provider will do so. At the end of the encounter, participants will fill out a final survey. Research staff will measure the length of the strings of all IUDs prior to routine disposal of the device.


Eligibility criteria: Inclusion Criteria:

* English or Spanish speaking
* Present to Boston Medical Center Yawkey for removal of IUD and have been consented for removal
* Are eligible for removal of IUD in the office setting

Exclusion Criteria:

* Current incarceration

Primary outcomes:
measure: Change in proportion of participants who are willing to attempt IUD self-removal
timeFrame: baseline, 15-30 minutes
measure: Proportion of participants who attempt IUD self-removal
timeFrame: 15-30 minutes
Secondary outcomes:
measure: Success of IUD self removal
timeFrame: 1 day
Other outcomes:
Locations:
city: Boston
country: United States
facility: Boston Medical Center
state: Massachusetts
Study officials:
affiliation: Boston Medical Center, Obstetrics and Gynecology
name: Melissa Wong, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01986738: A Pilot Trial to Determine the Extent of Inter- and Intra-Treatment Organ Motion Using Active Breathing Control Device (ABC) in Patients With Pancreatic Cancer
Official title: A Pilot Trial to Determine the Extent of Inter- and Intra-Treatment Organ Motion Using Active Breathing Control Device (ABC) in Patients With Pancreatic Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pancreatic Cancer
Lead sponsor: University of Michigan Rogel Cancer Center
Sponsor class: OTHER
First posted: 2013-11-18
Enrollment: 9
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: pancreatic cancer patients undergoing radiation treatment with active breathing control will be asked if they would like to participate.

Brief summary: This is a study to assess the motion of pancreatic tumors during radiation therapy using Computed Tomography (CT) Scans and an Active Breathing Control (ABC) Device.


Eligibility criteria: Inclusion Criteria:

* Patients ≥ 18 years of age
* A working diagnosis (with or without histologic confirmation) of pancreatic cancer
* A plan to treat with radiotherapy (or chemoradiotherapy)
* Patients must have fiducial marker(s) endoscopically placed within the pancreas for clinical treatment.

Exclusion Criteria:

* Previous abdominal radiotherapy.
* Patients with a history of major abdominal surgery.
* Patients who are pregnant.

Primary outcomes:
measure: Distance traveled by the pancreatic tumor during radiation treatment using Computed Tomography (CT) Scans and an Active Breathing Control (ABC) Device
timeFrame: Weeks -3 to -1, Week 1, Week 3, Week 5
measure: Distance traveled by the pancreatic tumor between radiation treatments using Computed Tomography (CT) Scans and an Active Breathing Control (ABC) Device
timeFrame: Week -3 to -1, Week 1, Week 3, Week 5
Secondary outcomes:
measure: Probability of surrounding normal tissue being a particular distance from the tumor marker at any time point.
timeFrame: Week -1 to -3, Week 1, Week 3, Week 5
measure: Assess the impact of the determined treatment margins on the radiation dose to normal tissues and the ability to escalate dose to the tumor using Intensity-Modulated Radiation Therapy (IMRT)
timeFrame: Analysis will take place after treatment at approximately week 6
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan Cancer Center
state: Michigan
Study officials:
affiliation: University of Michigan Rogel Cancer Center
name: Kyle Cuneo, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05600738: Network Effects of Therapeutic Deep Brain Stimulation
Official title: Network Effects of Therapeutic Deep Brain Stimulation
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Intractable Epilepsy
Keywords: Deep brain stimulation (DBS)
neuromodulation therapy
Responsive Neurostimulation (RNS)
Lead sponsor: The University of Texas Health Science Center, Houston
Sponsor class: OTHER
First posted: 2022-10-31
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to map the acute, short-term cortical evoked responses to thalamic electrical stimulation in persons with intractable epilepsy


Eligibility criteria: Inclusion Criteria:

* diagnosis of Epilepsy
* undergoing neuromodulation therapy with clinically implanted neuromodulation devices (DBS, RNS)
* followed in the outpatient epilepsy clinic

Exclusion Criteria:

* pregnant women
* active psychosis, major depression, or suicidal ideation in the preceding year
* Intelligence quotient (IQ) less than 70 as measured by clinical neuropsychological evaluation
* Do not agree to share their medical records for research purposes

Primary outcomes:
measure: Change in amplitude of evoked potentials metrics as assessed by the scalp EEG
timeFrame: Baseline, Intra intervention (about 20 minutes after baseline)
measure: Change in amplitude of evoked potentials metrics as assessed by the scalp EEG
timeFrame: Baseline, post intervention (about 2 hours after baseline )
measure: Change in latencies of evoked potentials and phase synchronization metrics recorded as assessed by the scalp EEG
timeFrame: Baseline, Intra intervention (about 20 minutes after baseline)
measure: Change in latencies of evoked potentials and phase synchronization metrics recorded as assessed by the scalp EEG
timeFrame: Baseline, post intervention (about 2 hours after baseline )
Secondary outcomes:
measure: Change in reaction time to visual stimuli measured as vigilance score assessed by the Psychomotor Vigilance test (PVT)
timeFrame: Baseline, Intra intervention (about 20 minutes after baseline)
measure: Change in reaction time to visual stimuli measured as vigilance score assessed by the Psychomotor Vigilance test (PVT)
timeFrame: Baseline, post intervention (about 2 hours after baseline)
Other outcomes:
Locations:
city: Houston
country: United States
facility: The University of Texas Health Science Center at Houston
state: Texas
Study officials:
affiliation: The University of Texas Health Science Center, Houston
name: Sandipan Pati, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02752438: Rescue High Frequency Oscillatory Ventilation in Newborns Who Do Not Respond to Conventional Ventilation
Official title: Rescue High Frequency Oscillatory Ventilation in Newborns Who Do Not Respond to Conventional Ventilation
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Mechanical Ventilatory Failure
Keywords: high frequency oscillatory ventilation
rescue
newborn
Lead sponsor: Ankara University
Sponsor class: OTHER
Collaborators: name: Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
name: Etlik Zubeyde Hanim Womens
name: Zeynep Kamil Maternity and Pediatric Research and Training Hospital
name: Gazi University
name: Istanbul Medeniyet University
name: Dr. Behcet Uz Children's Hospital
name: Celal Bayar University
name: Special Metro Hospital
name: Konya Meram State Hospital
name: Inonu University
First posted: 2016-04-27
Enrollment: 400
Sex: ALL
Minimum age (years): 1
Maximum age (years): 28
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Newborns with respiratory insufficiency in spite of conventional mechanical ventilation are candidates for the study. When the patient is switched to HFOV for rescue respiratory support, he/she will be followed and registered to online registry system.

Brief summary: Although High Frequency Oscillatory Ventilation (HFOV) has been used in case of unresponsive to conventional mechanical ventilation both in children and newborns, there is no data on its success and the factors that affect its success in the literature.

Detailed description: Although High Frequency Oscillatory Ventilation (HFOV) has been used in case of unresponsive to conventional mechanical ventilation both in children and newborns, there is no data on its success and the factors that affect its success in the literature.

The aim of the study is to define the factors that affect the success of HFOV in newborns who do not respond to conventional mechanical ventilation through an online registry among neonatal intensive care units in Turkey.

Eligibility criteria: Inclusion Criteria:

* patients switched to HFOV in case of unresponse to conventional ventilation
* stay on HFOV for at least 4 h

Exclusion Criteria:

* any congenital anomaly
* HFOV duration less then 4 h

Primary outcomes:
measure: Survival
timeFrame: 3 months
Secondary outcomes:
measure: Cut-off gestational age for survival
timeFrame: 3 months
measure: Cut-off birthweight for survival
timeFrame: 3 months
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara University Children's Hospital
Study officials:
affiliation: Ankara University
name: Omer Erdeve
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00002038: Non-Comparative Study of Fluconazole in Patients With Serious Mycoses and Who Cannot Be Treated With Conventional Antifungal Therapy
Official title: Non-Comparative Study of Fluconazole in Patients With Serious Mycoses and Who Cannot Be Treated With Conventional Antifungal Therapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Candidiasis
Mycoses
HIV Infections
Keywords: Mycoses
Drugs, Investigational
Fluconazole
Lead sponsor: NIH AIDS Clinical Trials Information Service
Sponsor class: INDUSTRY
First posted: 2001-08-31
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: The primary purpose of this protocol is to provide fluconazole for the treatment of individual patients who require therapy for serious or life-threatening systemic fungal infection, who have failed on conventional antifungal therapy or have had unacceptable reactions to conventional antifungal therapy, and who are ineligible for other established fluconazole clinical trial protocols.


Eligibility criteria: Exclusion Criteria

Co-existing Condition:

A patient will be excluded if he/she has previously had an unacceptable adverse effect due to fluconazole.

A patient will be excluded if he/she has previously had an unacceptable adverse effect due to fluconazole.

AMENDED:

* 900207 Open only to unapproved indications and/or age ranges.
* Original design:
* Patients with clinically established serious or life-threatening systemic fungal disease will be considered if conventional fungal therapy is not an acceptable alternative. Unacceptability of conventional therapy is defined as:
* Failure of conventional therapy to control or eradicate infection after appropriate trial(s) of generally accepted regimen(s).
* Serious and unacceptable untoward reaction(s) to conventional antifungal therapy.
* OR A major contraindication to the use of conventional antifungal therapy.
* The patient must be ineligible or have no access to other established fluconazole investigational protocols. The final judgment of patient acceptability for inclusion lies with the Pfizer Clinical Monitor.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Groton
country: United States
facility: Pfizer Central Research
state: Connecticut
Study officials:
References:
Clinical trial NCT06597838: Development and Validation of a Real-time Prediction Model for Acute Kidney Injury in Hospitalized Patients
Official title: Development and Validation of a Real-time Prediction Model for Acute Kidney Injury in Hospitalized Patients
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Prediction Model
Lead sponsor: Peking University First Hospital
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 161876
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients admitted to five hospitals during the study period.

Brief summary: Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no prediction model targeting AKI among general hospitalized patients in developing countries has been published. We developed a simple, real-time, interpretable AKI prediction model for general hospitalized patients from a large tertiary hospital in China, and validated it across five independent, geographically distinct, different tiered hospitals.

Detailed description: Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no prediction model targeting AKI among general hospitalized patients in developing countries has been published. We developed a simple, real-time, interpretable AKI prediction model for general hospitalized patients from a large tertiary hospital in China using the machine learning technique, and then validated the performance of the prediction model across five independent, geographically distinct, different tiered hospitals in China.

Eligibility criteria: Inclusion Criteria:

* Adult patients (18 years and older) admitted to five hospitals during the study period

Exclusion Criteria:

* Have less than 2 documented serum creatinine (Scr) measurements during hospitalization
* Being diagnosed with end-stage renal disease (ESRD)
* Maintained on dialysis or had an initial Scr greater than or equal to 4.0 mg/dL at admission
* Developed AKI prior to admission or within 24 hours after admission
* Length of stay shorter than 24 hours
* Underwent kidney transplantation or nephrectomy during hospitalization
* With all Scr measurements lower than or equal to 0.6 mg/dL from 90 days prior to admission until discharge.

Primary outcomes:
measure: Predictive performance of the prediction model for Acute Kidney Injury
timeFrame: through study completion, varied from one to three years in different validation cohorts.
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University First Hospital
state: Beijing
Study officials:
affiliation: Peking University First Hospital
name: Li Yang
role: STUDY_DIRECTOR
References:
Clinical trial NCT01518738: Attention Training
Official title: Attention Training
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Attention
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
First posted: 2012-01-26
Enrollment: 94
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to understand whether attention training is effective in moderating mind wandering.

Detailed description: Our subjective worlds are built from those things in our internal and external environments that capture our attention. Environments can be ambiguous with respect to which objects are most important for our attention, and the characteristics of stimuli that allow them to dominate attention are thus of great interest. Self-relevant objects, such as internally generated experience (e.g. thought), may receive substantial attention, but research on this dimension has been hampered by the difficulty of measuring such objects experimentally. The proposed study seeks to make headway in this area using several behavioral (accuracy, response time, response pattern) measures, with the hypothesis that internally generated experience will vie for attention in a way reflected by behavior. Such research will extend previous work the investigators' lab has done studying stimulus parameters that influence attention, and as a whole may present a more complete picture of how objects and attention interact to shape our worlds.

Eligibility criteria: Exclusion Criteria:

* Non-English speakers

Inclusion Criteria:

* Must be able to use a computer

Primary outcomes:
measure: change in mind wandering frequency after intervention
timeFrame: before intervention and up to 100 weeks later
Secondary outcomes:
Other outcomes:
Locations:
city: Madison
country: United States
facility: University of Wisconsin Brogden Psychology Building
state: Wisconsin
Study officials:
affiliation: University Wisconsin Madison
name: Richard Davidson, PhD
role: PRINCIPAL_INVESTIGATOR
References: