Clinical trial NCT04524468: Right Ventricular Function in End-stage Renal Disease Patients
Official title: The Impact of Different Dialysis Modalities on Right Ventricular Function in End-stage Renal Disease Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Transthoracic Echocardiography
Hemodialysis
Keywords: echocardiography
hemodialysis
peritoneal dialysis
right ventricle
Lead sponsor: Antalya Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2020-08-24
Enrollment: 83
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: End-stage renal disease patients on a regular dialysis program at least 6 months

Brief summary: Right ventricular (RV) dysfunction is a major cause of heart failure and mortality in end-stage renal disease (ESRD) patients. The aim of the study was to evaluate the long-term impacts of different dialysis modalities on RV function assessed by conventional echocardiography in ESRD patients with preserved left ventricular function. The study included 83 ESRD patients grouped as follows: peritoneal dialysis (PD; n=46) and hemodialysis with brachial arterio-venous fistula (HD; n=37). Conventional echocardiography including 2D and tissue Doppler imaging was performed in all patients. Echocardiographic parameters were compared between groups.

Detailed description: Cardiovascular diseases (CVD) are the main causes of death in patients undergoing dialysis. Right ventricular (RV) dysfunction is one of the major predictors of mortality and heart failure in this patient group. It has been shown that patients undergoing hemodialysis (HD) which is usually carried out via a surgically created arteriovenous fistula (AVF) have an increased risk for pulmonary hypertension and poorer right ventricular function compared with healthy controls . However, there are few data comparing the patients undergoing HD and peritoneal dialysis (PD), in terms of echocardiographic right ventricular function.

The aim of the present study was to elucidate the impact of both long term PD and HD therapy via brachial AVF on RV function in patients with preserved left ventricular (LV) function.

Patients undergoing dialysis were grouped as follows: 46 patients on PD and 37 patients on HD with brachial AVF. All of the study patients underwent transthoracic echocardiography. Left and right ventricular parameters were compared between two groups.

Eligibility criteria: Inclusion Criteria:

* End-stage renal disease patients on a regular dialysis program
* Being on dialysis at least 6 months
* \>18 years old

Exclusion Criteria:

* Ischemic heart disease
* Left ventricular systolic dysfunction with an ejection fraction (EF) of less than 55 %
* Valvulopathy
* Left bundle branch block
* Atrial fibrilation
* Previous renal transplantation
* Chronic obstructive pulmonary disease
* Interstitial lung diseases
* Connective tissue disorders
* Chronic thromboembolic disease
* Congenital left-to-right shunt
* Primary pulmonary hypertension

Primary outcomes:
measure: Estimation of right ventricular function in end-stage renal disease patients
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Antalya
country: Turkey
facility: Antalya Research and Training Hospital
Study officials:
affiliation: Antalya Research and Training Hospital
name: Duygu Ersan Demirci, MD
role: PRINCIPAL_INVESTIGATOR
References: