louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06553495: A Comparative Analysis of Intertransverse Nerve Block and Paravertebral Nerve Block in Endoscopic Hepatectomy
Official title: A Comparative Analysis of Intertransverse Nerve Block and Paravertebral Nerve Block in Endoscopic Hepatectomy
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Pain
Lead sponsor: The Second Affiliated Hospital of Chongqing Medical University
Sponsor class: OTHER
First posted: 2024-08-14
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to compare the analgesic effect of intertransverse nerve block and paravertebral nerve block after endoscopic hepatectomy, evaluate its effectiveness and safety, and provide new ideas and clinical basis for postoperative pain management of liver surgery.

Detailed description: This study was a prospective, double-blind, randomized controlled trial. Patients who were eligible for laparoscopic partial liver resection in our center were included, with intertransverse nerve block as the experimental group and paravertebral nerve block as the control group. Through the analysis of postoperative pain score 30min to 24h, the number of effective analgesic pump compressions within 24h, the amount of analgesic drugs used, complications and other data, To evaluate the efficacy and safety of intertransverse nerve block in patients undergoing laparoscopic partial liver resection.

Eligibility criteria: Inclusion Criteria:1:

1.18-80 years old adult, BMI\<27.9kg/m2

2: 2. American Society of Anesthesiologists ASA Grade I-III

3: 3. Patients with laparoscopic partial liver resection such as liver tumors

4: 4. Willing to participate in this study and sign the informed consent form

-

Exclusion Criteria:

1. 1. The patient or family member refuses to sign the informed consent form
2. 2. Blood coagulation dysfunction, local infection
3. 3. Those who have communication, communication disorders or mental abnormalities
4. 4. Patients with severe heart, pulmonary and renal insufficiency or patients with central system diseases
5. 5. For any reason, it cannot be matched with the study or the researcher believes that it is not appropriate to be included in this experiment.

   -

Primary outcomes:
measure: The number of effective compressions of the analgesic pump within 24 hours after surgery
timeFrame: Within 24 hours after the operation
Secondary outcomes:
Other outcomes:
Locations:
city: Chongqing
country: China
facility: The Second Affiliated Hospital Of Chongqing Medical University
state: Chongqing
Study officials:
References:
Clinical trial NCT04508595: The RestEaze Ambulatory Sleep Monitor for Detection of Leg Movements During Sleep in Adults and Children With a Sleep Disturbance
Official title: The RestEaze Ambulatory Sleep Monitor for Detection of Leg Movements During Sleep in Adults and Children With a Sleep Disturbance
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sleep
Lead sponsor: Tanzen Medical Inc
Sponsor class: INDUSTRY
First posted: 2020-08-11
Enrollment: 200
Sex: ALL
Minimum age (years): 5
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Outpatients presenting to sleep medicine clinic for evaluation.

Brief summary: This observational study will test and evaluate the RestEaze ambulatory sleep monitor for the detection and classification of leg movements during sleep (LMS) and other sleep measures.


Eligibility criteria: Inclusion Criteria:

* Ages between 5 -75
* General good health and ambulatory
* Sleep complaint or other diagnosis that affects sleep (e.g. ADHD) with likely concomitant abnormal LMS requiring either HST or PSG
* Reports no significant problems sleeping in a new bed and bedroom away from home
* (If applicable) Parent or guardian available to spend the night with the child during the sleep study

Exclusion Criteria:

• Amputation that would preclude use of wrist actigraph or the RestEaze device

Primary outcomes:
measure: Algorithm
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Milpitas
country: United States
facility: Comprehensive Sleep Center
state: California
Study officials:
References:
Clinical trial NCT01461395: Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm
Official title: A Non-invasive Method to Assess DNA Damage in Individual Sperm
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: DNA Damage
Other Complications Associated With Artificial Fertilization
Keywords: IVF
Lead sponsor: University of South Florida
Sponsor class: OTHER
First posted: 2011-10-28
Enrollment: 84
Sex: MALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: IVF patients already undergoing therapy and providing a semen sample for sperm count

Brief summary: The purpose of this study is to find a non-invasive way to discover DNA (deoxyribonucleic acid, which is the genetic material inside your cells) alterations in the sperm's head, in the near future leading us to choose the "good sperm" in a simplified manner. This could then increase chances of a successful in-vitro fertilization (IVF) treatment when there are sperm abnormalities.

Detailed description: If you take part in this study,

1. Your physician is asking you to provide a semen sample as you already would. The sample will be taken to the IVF lab which would occur if you were not involved in this research. The part that would be thrown away is then further analyzed under a polarized light microscope. The sample is exposed to ultraviolet (UV) light for a period of 20 minutes after which it is analyzed under the microscope again, looking for any changes when compared the sample that was not exposed to UV light. The sample is then discarded.
2. Your name will be removed from the sample after the regular semen analysis is done; therefore there will be no way of associating the research results with you. No information will be needed from you and you will not be contacted in the future regarding this research.

Eligibility criteria: Inclusion Criteria:

* Age 18-60 years
* provide informed consent
* Already providing a semen sample as routine therapy in IVF

Exclusion Criteria:

-unable to provide informed consent

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Tampa
country: United States
facility: University of South Florida South Tampa Center
state: Florida
Study officials:
affiliation: University of South Florida
name: Celso Silva, M.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02897414: ER/LA Opioid Analgesics - Surveillance Monitoring of State Medical Examiner Databases
Official title: Extended Release/Long Acting (ER/LA) Opioid Analgesics Risk Evaluation and Mitigation Strategy (REMS) Medical Examiner Surveillance Monitoring Protocol
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Opioid-related Disorders
Opioid Addiction
Narcotic Abuse
Drug Abuse
Lead sponsor: ER/LA Opioid REMS Program Companies (RPC)
Sponsor class: INDUSTRY
First posted: 2016-09-13
Enrollment: 13015
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Fatalities associated with prescription opioids as reported in State medical examiner databases from multiple states.

Brief summary: In April 2011, the U.S. Food and Drug Administration (FDA) determined that a class-wide risk evaluation and mitigation strategy (REMS) for all extended-release (ER) and long-acting (LA) opioid medications was necessary to support national efforts to reduce serious adverse outcomes resulting from opioid abuse. This study will evaluate trends before and after the ER/LA REMS implementation for changes in mortality rates associated with prescription opioids utilizing state medical examiner databases from multiple states. Databases from 2005 through the most recent year available will be obtained.


Eligibility criteria: Inclusion Criteria:

* Fatalities associated with prescription opioids in several states during 2005-2015 (or later).

Exclusion Criteria:

* None

Primary outcomes:
measure: Rates of fatalities associated with prescription opioids per size of population covered by the surveillance systems
timeFrame: Review over period from January 2005 to 2016
measure: Rates of fatalities associated with prescription opioids per number of prescriptions dispensed in the states
timeFrame: Review over period from January 2005 to 2016
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00795314: Propofol-butorphanol Anesthesia During Uterine Curettage
Official title: Propofol-butorphanol Combined Anesthesia During Uterine Curettage on Abortion
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Abortion
Curettage
Keywords: Opioids
General anesthesia
Lead sponsor: Nanjing Medical University
Sponsor class: OTHER
First posted: 2008-11-21
Enrollment: 150
Sex: FEMALE
Minimum age (years): 19
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Uterine curettage is usually performed under the anesthesia of propofol-fentanyl or para-cervical block,of which generally has significant incidence of respiratory depression which increases the demand on intraoperative monitoring, or has unavoidable insufficient blockade which results in intraoperative suffering of pain. Butorphanol is an analgesic with combined effects on mu and kappa opioid receptors leading to a role as analgesia and sedation. The investigators hypothesized that combined propofol with butorphanol during uterine curettage would produce optimal effectiveness of these two drugs by adding sedative and analgesic effects together. In addition, it would decrease the intraoperative consumption of propofol without increase the incidence of side effects. Furthermore, such combination would alleviate postoperative pain.


Eligibility criteria: Inclusion Criteria:

* ASA status I-II;
* Performing abortion operation (medical- or drug-induced);
* Requiring painless abortion;

Exclusion Criteria:

* \< 19yrs, and \>= 45yrs;
* History of central active drugs administration;
* Drug abuse;
* Hypertension;
* Diabetes;
* Any other chronic diseases;
* Allergy to the study drugs;
* Habit of over-volume alcohol drinking;
* Records of history of centrally active drug use and psychiatry;
* Any organic disorders.

Primary outcomes:
measure: Intraoperative awareness
timeFrame: During the whole process of anesthesia
Secondary outcomes:
measure: Bispectral Index (BIS) value
timeFrame: During the whole process of anesthesia
measure: Anesthetic consumptions
timeFrame: From the start of operation to the end of surgical procedures
measure: Postoperative pain
timeFrame: Since the end of the operation to 48 h follow-up.
measure: Postoperative bleeding
timeFrame: Since the end of operation to 48 h follow-up
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Nanjing Maternal and Child Health Care Hospital
state: Jiangsu
Study officials:
affiliation: Nanjing Medical University
name: XiaoFeng Shen, MD
role: STUDY_CHAIR
References:
Clinical trial NCT00849914: Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer
Official title: Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Skin Cancer
Lead sponsor: Ruhr University of Bochum
Sponsor class: OTHER
First posted: 2009-02-24
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: dermatologic primary care clinic

Brief summary: MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the expression profiles for the two most important miRNA processing enzymes Dicer and Drosha of actinic keratoses, basal cell carcinoma and squamous cell carcinoma are compared to healthy skin tissue.


Eligibility criteria: Inclusion Criteria:

* Patients with actinic keratoses, squamous cell carcinoma or basal cell carcinoma of the skin

Exclusion Criteria:

* Patients under 18 years of age
* Patients with other forms of cancer in previous medical history

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Bochum
country: Germany
facility: Department of Dermatology and Allergology, Ruhr-University Bochum
Study officials:
affiliation: Department of Dermatology and Allergology, Ruhr-University Bochum
name: Prof. Dr. Peter Altmeyer
role: PRINCIPAL_INVESTIGATOR
References:
citation: Sand M, Gambichler T, Skrygan M, Sand D, Scola N, Altmeyer P, Bechara FG. Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer. Cancer Invest. 2010 Jul;28(6):649-53. doi: 10.3109/07357901003630918.
Clinical trial NCT01654614: Diagnostic Capacity of Keratoconus Match Index and Keratoconus Match Probability in Forme Fruste Keratoconus
Official title: Diagnostic Capacity of Keratoconus Match Index and Keratoconus Match Probability in Forme Fruste Keratoconus
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Forme Fruste Keratoconus (FFK)
Keywords: Keratoconus match index
keratoconus probability index
ocular response analyzer
Pentacam
forme fruste keratoconus
Lead sponsor: Democritus University of Thrace
Sponsor class: OTHER
First posted: 2012-08-01
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All participants were recruited from the Outpatients Cornea service, in a consecutive if eligible basis

Brief summary: Primary objective of this study was to evaluate the diagnostic capability of keratoconus match index (KMI) and keratoconus match probability (KMP) indexes in forme fruste keratoconus (FFK), and their association with a series of Pentacam-derived keratconus (KC) indexes. KMI and KMP parameters are KC-specifc indexes that are measured by Ocular Response Analyzer (ORA), based on the distinct ORA-derived waveform characteristics of KC eyes.

Study participants were recruited from the Cornea Outpatient service in a consecutive if eligible basis. Two study groups were formed: a) FFK group (FFKG) that included patients diagnosed with FFK, and, b) Control group (CG) was formed by refractive surgery candidates.

All ORA (Reichert Ophthalmic Instrument, Buffalo, NY, USA, software version: 3.01)and Pentacam (Pentacam HR, Oculus Optikgerate GmbH, Heidelberg, Germany)measurements were performed by the same experienced operator in a consistent way


Eligibility criteria: Inclusion Criteria:

* diagnosis of keratoconus KC in the fellow eye according to the Amsler-Krumleich criteria (FFKG)
* KISA index between 60 and 100% in the FFK eye (FFKG)
* lack of any KC-related findings / signs in the slit-lamp biomicroscopy (FFKG)
* uneventful ophthalmologic history (CG)
* no indications of corneal pathology in slit-lamp biomicroscopy and Placido disk-based videokeratography (CG)
* KISA index value less than 60% (CG)

Exclusion Criteria:

for both study groups:

* previous incisional eye surgery
* corneal scars and opacities
* history of herpetic keratitis, severe eye dryness
* pregnancy or nursing
* current corneal infection
* glaucoma
* suspicion for glaucoma
* IOP lowering treatment
* underlying autoimmune disease

Primary outcomes:
measure: Keratoconus Match Index (KMI)
timeFrame: one day
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandroupolis
country: Greece
facility: Eye Institute of Thrace (ΕΙΤ)
state: Evros
Study officials:
References:
citation: Labiris G, Giarmoukakis A, Gatzioufas Z, Sideroudi H, Kozobolis V, Seitz B. Diagnostic capacity of the keratoconus match index and keratoconus match probability in subclinical keratoconus. J Cataract Refract Surg. 2014 Jun;40(6):999-1005. doi: 10.1016/j.jcrs.2013.08.064. Epub 2014 Apr 6.
Clinical trial NCT04456114: Micro-abrasive Blasting vs Acid Etching of Orthodontic Bracket Bases
Official title: Micro-abrasive Blasting vs Acid Etching of Orthodontic Bracket Bases: A Scanning Electron Microscope Study and an Eighteen Month Randomized Clinical Control
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Orthodontic Appliances
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2020-07-02
Enrollment: 340
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: parallel-group, split mouth, triple blinded, randomized control trial
Primary purpose: TREATMENT

Brief summary: To describe a method of acid etching the base of a bracket, and to compare the bond failures between micro-abrasive blasted (sandblasted) brackets and acid etched brackets over an eighteen month period

Detailed description: The aims of this randomized control trial are:

1. To describe a method to chemically etch the bases of stainless steel orthodontic brackets.
2. To observe the changes in the micro-structure of the brackets with sandblasted bases and acid-etched bases under an electron microscope.
3. To compare the failure of orthodontic brackets with a chemical etched base versus a sandblasted base bonded with composite using the conventional acid etch technique, over a follow-up of 18 months

Eligibility criteria: Inclusion Criteria:

* Patients about to undergo fixed orthodontic therapy

Exclusion Criteria:

* Patients with cavities, history of fixed orthodontic therapy, recent bleaching

Primary outcomes:
measure: Bond Failure Rate
timeFrame: 18 months after placement of brackets on the teeth
Secondary outcomes:
Other outcomes:
Locations:
city: Islamabad
country: Pakistan
facility: Islamic International Dental College
Study officials:
affiliation: Riphah International University
name: Owais K Durrani, FFDRCSI
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05496114: Medical Checklists in the Emergency Department
Official title: The Impact of Medical Checklists on the Management of Acute Situations in the Emergency Department. A Simulation-based Randomised Controlled Trial.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Emergencies
Tricyclic Antidepressant Poisoning
Tricyclic Antidepressant Toxicity
Keywords: Medical checklists
Lead sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sponsor class: OTHER
First posted: 2022-08-11
Enrollment: 56
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants (emergency physicians) will be allocated to performing the scenario with or without checklist in a randomized fashion on a 1:1 ratio. Computerized randomization will take place using an online randomization module.
Primary purpose: TREATMENT

Brief summary: This study aims to investigate whether the use of medical checklists in the emergency department can decrease resuscitation time in critically ill patients.

Detailed description: A scenario evaluating tricyclic antidepressant poisoning will be carried out with and without medical checklist access. Emergency physicians from the Netherlands who are willing to take part in the study are randomly allocated to perform the scenario with or without checklists.

Eligibility criteria: Inclusion Criteria:

* Emergency Physicians recognised by KNMG (Koninklijke Nederlandsche Maatschappij tot bevordering van de Geneeskunst) working in the Netherlands

Exclusion Criteria:

* Residents (in Dutch: AIOS) Emergency Medicine
* Interns (in Dutch: ANIOS) Emergency Medicine

Primary outcomes:
measure: Duration of the scenario
timeFrame: Through study completion, indicated 10 months
Secondary outcomes:
measure: Number of indicated interventions performed by the emergency physician
timeFrame: Through study completion, indicated 10 months
measure: Satisfaction of emergency physicians with the checklists
timeFrame: Through study completion, indicated 10 months
Other outcomes:
Locations:
city: Amsterdam
country: Netherlands
facility: Amsterdam University Medical Center
Study officials:
affiliation: Amsterdam University Medical Center
name: Malu van der Capellen, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dryver E, Lundager Forberg J, Hard Af Segerstad C, Dupont WD, Bergenfelz A, Ekelund U. Medical crisis checklists in the emergency department: a simulation-based multi-institutional randomised controlled trial. BMJ Qual Saf. 2021 Sep;30(9):697-705. doi: 10.1136/bmjqs-2020-012740. Epub 2021 Feb 17.