louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01488695: GlideScope Groove Versus Macintosh Blade for Double-Lumen Endotracheal Tube Intubation
Official title: Comparison of GlideScope Groove to Macintosh Blade for Orotracheal Intubation With Double-Lumen Endotracheal Tube: a Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Intubation, Intratracheal
Keywords: intubation
double lumen tube
Lead sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sponsor class: OTHER
First posted: 2011-12-08
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A new GlideScope videolaryngoscope has been developed, which utilizes a track on the superior surface of the blade to guide the endotracheal tube, which is advanced in the track as opposed to "free-hand" along the inferior surface, where the camera is located. This new GlideScope can be used for double-lumen endotracheal tubes (DLT). The investigators hypothesize that this GlideScope will be easier to use than the Macintosh blade.


Eligibility criteria: Inclusion Criteria:

* Any adult patient booked for elective surgery requiring orotracheal intubation with a double lumen endotracheal tube.

Exclusion Criteria:

1. Any patient with cervical spine abnormalities.
2. Any patients with known or probable difficult airways.
3. Any patient requiring rapid sequence induction.

Primary outcomes:
measure: Duration of Intubation
timeFrame: Day 1
Secondary outcomes:
measure: Number of intubation attempts
timeFrame: Day 1
measure: Number of failures to intubate
timeFrame: Day 1
measure: Use of external laryngeal pressure
timeFrame: Day 1
measure: Laryngoscopic grade distribution
timeFrame: Day 1
measure: Presence of Sore throat
timeFrame: Day 3
Other outcomes:
Locations:
city: London
country: Canada
facility: London Health Sciences Center University Hospital
state: Ontario
city: London
country: Canada
facility: Victoria Hospital
state: Ontario
Study officials:
affiliation: University of Western Ontario, Canada
name: Timothy P Turkstra
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05883995: Avis-PHAGEinLYON Clinic
Official title: Avis-PHAGEinLYON Clinic
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Bone Infection
Keywords: bacteriophage
medical advice
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2023-06-01
Enrollment: 1500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1500 patients with severe infection treated with phagotherapy will be included in the study.

Brief summary: Avis-PHAGEinLYON Clinic study is a single site non-interventional retrospective and prospective study, initiated by the Hospices Civils de Lyon. Population targeted are patients referred to the Hospices Civils de Lyon for a medical advice for a phage therapy from 2015 to 2028. The primary objective is to quantify the phage therapy requests received at the Hospices Civils de Lyon. 1500 patients will be included in the study.


Eligibility criteria: Inclusion Criteria:

* - Patient referred to the Hospices Civils de Lyon for a phage therapy request from 01/01/2015 to 01/01/2028.
* Avis-PHAGEinLYON clinic study information notice provided to the patient

Exclusion Criteria:

* - Opposition of trial participant

Primary outcomes:
measure: Number of phage therapy requests
timeFrame: at inclusion
Secondary outcomes:
Other outcomes:
Locations:
city: Lyon
country: France
facility: Centre de Référence des Infections Ostéo-Articulaires complexes (CRIOAc) - Hôpital de la Croix-Rousse
Study officials:
References:
Clinical trial NCT04448795: Impact of Highest Drain Fluid Amylase Levels on Surgical Outcomes and Postoperative Interventions in Patients Undergoing Pancreaticoduodenectomy
Official title: Significance of Drain Amylase Levels After Pancreaticoduodenectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pancreas; Fistula
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2020-06-26
Enrollment: 600
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: underwent PD in Chang Gung Memorial Hospital at Linkou

Brief summary: This study investigated the impact of highest drain fluid amylase (DFA) level on postoperative pancreatic fistula (POPF) severity and outcomes of patients undergoing pancreaticoduodenectomy (PD) with POPF. Patient demographics of biochemical POPF and clinically relevant POPF (CR-POPF) were compared. Predictive factors were assessed using binary logistic regression. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff value of highest DFA (beyond 3 days post-PD). The investigators compared length of hospital stay, surgical mortality rates, and need for postoperative interventions by highest DFA level.


Eligibility criteria: Inclusion Criteria:

* underwent PD from October 2010 to September 2018 in our institution

Exclusion Criteria:

* younger than 20 years of age
* clinical information was unavailable due to private or legal issues
* receiving PD without pancreaticojejunostomy

Primary outcomes:
measure: postoperative pancreatic fistula
timeFrame: through study completion, an average of 2 month
Secondary outcomes:
measure: postoperative interventions
timeFrame: through study completion, an average of 2 month
measure: length of hospital stay
timeFrame: through study completion, an average of 2 month
measure: 30-day mortality rates
timeFrame: 30 day
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03949595: Rapid Eating Is Linked to Emotional Eating in Obese Women Relieving From Bariatric Surgery
Official title: Rapid Eating Is Linked to Emotional Eating in Obese Women Relieving From Bariatric Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Keywords: Obese
Food behaviour
Eating rate
Lead sponsor: CHU de Reims
Sponsor class: OTHER
First posted: 2019-05-14
Enrollment: 116
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women suffering from obesity and their eating habits

Brief summary: The aim of the study was to analyse eating rate in comparison to other aspects of eating habits in women suffering from severe/massive obesity.

Detailed description: Eating rate is associated with BMI and weight gain in various populations and is a factor modulating the risk of complications after bariatric surgery. The aim of the present study is to determine whether common difficulties to change eating rate in subjects with obesity candidate to bariatric surgery could be due to more extensive abnormalities in eating behaviour.

Eligibility criteria: inclusion criteria :

* BMI ≥ 35 kg/m
* responses to a self-administered questionnaire distributed between November 2011 and March 2014 to female patients attending a nutrition consultation for overweight, or attending an outpatient visit prior to bariatric surgery, both within the Champagne-Ardenne Specialized Obesity Clinic, at the University Hospital Robert Debré in Reims, France
* Patients who agree to participate to the study
* Major patient

exclusion criteria :

* Patient under law protection
* Minor patient
* Patients with uncontrolled diabetes (HbA1c ≥ 8.0% at inclusion) or those treated with glucagon-like peptide-1 (GLP-1) receptor antagonists, as well as patients treated by glucocorticoids (their current treatment was systematically reported)

Primary outcomes:
measure: Eating Rate
timeFrame: Day 0
Secondary outcomes:
Other outcomes:
Locations:
city: Reims
country: France
facility: Damien JOLLY
Study officials:
References:
citation: Canterini CC, Gaubil-Kaladjian I, Vatin S, Viard A, Wolak-Thierry A, Bertin E. Rapid Eating is Linked to Emotional Eating in Obese Women Relieving from Bariatric Surgery. Obes Surg. 2018 Feb;28(2):526-531. doi: 10.1007/s11695-017-2890-4.
Clinical trial NCT02619695: Comparison of Ketoprofen Gel to Placebo in Mechanical Low Back Pain
Official title: Comparison of Ketoprofen Gel to Placebo in Patients Presented With Mechanical Low Back Pain to the Emergency Department: A Randomized Placebo Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Low Back Pain
Keywords: ketoprofen
gel
low back pain
emergency department
Lead sponsor: Akdeniz University
Sponsor class: OTHER
Collaborators: name: Pamukkale University
name: Celal Bayar University
name: Kocatepe University
First posted: 2015-12-02
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Mechanical low back pain is one most important emergency department presentations of patients seeking pain relief. Although parenteral pain killers such as opioids, non-steroidal anti-inflamatuar drugs and paracetamol are used commonly in these patients, application of analgesics in gel forms might be an reasonable alternative to these drugs with fewer adverse effects.

Detailed description: Mechanical low back pain is one most important emergency department presentations of patients seeking pain relief. Parenteral pain killers such as opioids, non-steroidal anti-inflamatuar drugs (NSAID) and paracetamol are used commonly in these patients. However, these drugs are not out of adverse effects and can not be used in some patients with diverse comorbidities. Gel forms of NSAIDs are used commonly in the outpatient clinics and shown to be effective in these patients by a Cochrane meta-analysis. However, there is no data on the effect of gel forms of analgesics in ED. The application of analgesics in gel forms might be a reasonable alternative to the paranteral drugs with fewer adverse effects.

The present study aimed to reveal the effect of ketoprofen gel in patients presented with low back pain to emergency department.

Eligibility criteria: Inclusion Criteria:

* Mechanical low back pain

Exclusion Criteria:

* Under 18 years old
* Over 65 years old
* Pain less than 40 mm in visual analogue scale
* Allergy to the study drug
* Drug or alcohol addiction
* Pregnancy and lactation

Primary outcomes:
measure: visual analogue scale at 30 minutes
timeFrame: 30 minutes
Secondary outcomes:
measure: Adverse effects
timeFrame: 30 minutes
Other outcomes:
Locations:
city: Denizli
country: Turkey
facility: Pamukkale University
Study officials:
affiliation: Pamukkale University
name: Mustafa Serinken, Professor
role: STUDY_DIRECTOR
References:
citation: Friedman BW, Dym AA, Davitt M, Holden L, Solorzano C, Esses D, Bijur PE, Gallagher EJ. Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. JAMA. 2015 Oct 20;314(15):1572-80. doi: 10.1001/jama.2015.13043.
Clinical trial NCT03684395: Accessibility to New Drugs Versus SOC in Sweden
Official title: Association Between Socioeconomic Factors and Use of Direct Oral Anticoagulants Versus Standard of Care (Warfarin) in Patients With Non-valvular Atrial Fibrillation in Sweden
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anticoagulation
Lead sponsor: Bayer
Sponsor class: INDUSTRY
First posted: 2018-09-25
Enrollment: 68056
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE

Brief summary: The healthcare system in Sweden is publicly funded and aims to provide equal access to care irrespective of socioeconomic status. This includes ensuring equity in drug treatment. Socioeconomic disparities have been shown to influence patient management and health outcomes in certain Swedish populations. The Swedish Board of Health and Welfare has stated that the prescription of new drugs, which are more expensive than generic standard of care drugs, might be influenced by patients' socioeconomic status.

To evaluate the association between socioeconomic factors and use of a DOAC (rivaroxaban, dabigatran, or apixaban) or standard of care (warfarin) in patients with NVAF in Sweden.


Eligibility criteria: Inclusion Criteria:

* Patients aged ≥18 years in Sweden with a diagnosis of NVAF (identified using International Classification of Diseases, version 10 \[ICD-10\]) codes in the National Patient Register) between 1 December 2011 and 31 December 2014 and with a first dispensed prescription for either a DOAC or warfarin following their NVAF diagnosis.

Exclusion Criteria:

* Patients with a dispensed prescription for a DOAC or warfarin prior to the index date (the date of first DOAC/warfarin purchase designated the index date)
* Patients with a dispensed prescription for more than one anticoagulant at index date.
* Patients with valvular atrial fibrillation

Primary outcomes:
measure: Correlation between socioeconomic factors and use of DOACs vs. Warfarin (as identified from the LISA database before the index date)
timeFrame: approximately 3 years
Secondary outcomes:
measure: Secular trends in the correlation between socioeconomic factors and use of DOACs (vs. warfarin) - Trends based on the date of prescription by year
timeFrame: approximately 3 years
Other outcomes:
Locations:
city: Stockholm
country: Sweden
Study officials:
References:
Clinical trial NCT03775395: HAIC Plus Lenvatinib vs HAIC Plus Sorafenib for Advanced HCC
Official title: Hepatic Artery Infusion Chemotherapy Plus Lenvatinib vs Hepatic Artery Infusion Chemotherapy Plus Sorafenib for Advanced Hepatocellular Carcinoma
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Hepatocellular Carcinoma
Keywords: Hepatocellular carcinoma
Hepatic artery infusion chemotherapy
Sorafenib
Lenvatinib
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2018-12-13
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy and safety of sorafenib combined with hepatic arterial infusion chemotherapy (HAIC) compared with lenvatinib combined with HAIC in patients with advanced hepatocellular carcinoma (HCC)


Eligibility criteria: Inclusion Criteria:

* The diagnosis of HCC was based on the diagnostic criteria for HCC used by the European Association for the Study of the Liver (EASL)
* Patients must have at least one tumor lesion that can be accurately measured according to EASL criteria.
* Barcelona clinic liver cancer-stage C
* Eastern Cooperative Oncology Group performance status of 0 to 2
* with no previous treatment
* No Cirrhosis or cirrhotic status of Child-Pugh class A only
* Not amendable to surgical resection ,local ablative therapy and any other cured treatment.
* The following laboratory parameters:
* Platelet count ≥ 75,000/μL
* Hemoglobin ≥ 8.5 g/dL
* Total bilirubin ≤ 30mmol/L
* Serum albumin ≥ 30 g/L
* ASL and AST ≤ 5 x upper limit of normal
* Serum creatinine ≤ 1.5 x upper limit of normal
* INR ≤ 1.5 or PT/APTT within normal limits
* Absolute neutrophil count (ANC) \>1,500/mm3
* Ability to understand the protocol and to agree to and sign a written informed consent document

Exclusion Criteria:

* Evidence of hepatic decompensation including ascites, gastrointestinal bleeding or hepatic encephalopathy
* Known history of HIV
* History of organ allograft
* Known or suspected allergy to the investigational agents or any agent given in association with this trial.
* Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy
* Evidence of bleeding diathesis.
* Patients with clinically significant gastrointestinal bleeding within 30 days prior to study entry.
* Known central nervous system tumors including metastatic brain disease

Primary outcomes:
measure: Overall survival
timeFrame: Time Frame: 12 months
Secondary outcomes:
measure: Time to progression
timeFrame: Time Frame: 12 months
measure: Adverse Events
timeFrame: [Time Frame: 30 days]
measure: Progression Free Survival (PFS)
timeFrame: Time Frame: 12 months
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Cancer Center Sun Yat-sen University
state: Guangdong
Study officials:
affiliation: Sun Yat-sen University
name: Ming Shi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02091895: Validation of Clinical Efficacy and Development of New Diagnostic Algorithm of Probe-based Confocal Laser Endomicroscopy in Patients With Lower Gastrointestinal Disorder
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Lower Gastrointestinal Disorders
Keywords: probe-based confocal laser endomicroscopy, lower gastrointestinal disorders
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2014-03-19
Enrollment: 311
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The aims of this research are to validate and develop of therapeutic strategies for patients with colorectal lesions in real time through pCLE(probe-based confocal laser endomicroscopy). Endomicroscopy is a technique for obtaining histology-like images from inside the human body in real-time. Total objections are 311 patients.

Specific research topics are as below.

1. Diagnosis and classification of colon polyps through pCLE
2. Evaluation of the depth of invasion of colorectal cancer or lateral growth type tumor through the pCLE
3. Differential diagnosis of colorectal submucosal tumor through the pCLE
4. Differential diagnosis of ileocecal ulcers through the pCLE

The study will be conducted to measure sensitivity, specificity, accuracy, amphoteric predict of pCLE diagnosis, and calculate the agreement of prediction compared to the pathological findings of lesions Check diagnostic agreement of technical phrases which are derived, the matching degree between observers, and will develope a new classification method based on this.


Eligibility criteria: Inclusion Criteria:

* Adults over 20 years old
* Patients with colorectal polyps
* Patients who undergo endoscopic submucosal dissection (ESD) due to lateral spreading tumors or early colorectal cancer
* Patients with submucosal tumor in colorectal cancer
* Patients with ileocecal ulcers
* Patients who consented to research

Exclusion Criteria:

* Patients who are impossible to biopsy or polypectomy due to underlying diseases.
* Patients who are not able to end the ESD because of a complication
* Patients who are already known the cause of ileocecal ulcers before the pCLE.
* Patients with contraindications to the use of disease fluorescent contrast agents
* Patients who did not consent to research
* Patients who are unsuitable for clinical trials in charge of the attending physician.

Primary outcomes:
measure: Sensitivity of pCLE diagnosis
timeFrame: 2 weeks
Secondary outcomes:
measure: Specificity of pCLE diagnosis
timeFrame: 2 weeks
measure: Accuracy of pCLE diagnosis
timeFrame: 2 weeks
measure: amphoteric predict of pCLE diagnosis
timeFrame: 2 weeks
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance hospital
Study officials:
References:
Clinical trial NCT04487795: Age-related Changes of Crystalline Lens Tilt and Decentration: A Swept-source Optical Coherence Tomography Study
Official title: Age-related Changes of Crystalline Lens Tilt and Decentration: A Swept-source Optical Coherence Tomography Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Crystalline Cataract
Lens; Anomaly
Keywords: crystalline lens tilt
crystalline lens decentration
swept-source optical coherence tomography
Lead sponsor: Wenzhou Medical University
Sponsor class: OTHER
First posted: 2020-07-27
Enrollment: 230
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Healthy volunteers and patients with age-related cataract at Eye hospital of Wenzhou Medical University

Brief summary: 230 participants at Eye Hospital of Wenzhou Medical University during June, 2019 and August, 2019 were enrolled in this study. 230 right eyes and 88 left eyes were included for the measurement. All the measurements were performed under non-mydriatic conditions in a dim examination room using the CASIA2 swept-source AS-OCT system.


Eligibility criteria: Inclusion Criteria：

* healthy volunteers and patients with age-related cataract

Exclusion Criteria:

* aphakia or pseudophakia
* any other ocular diseases with the exception of senile cataract
* any history of ocular surgery
* fixation difficulties caused by any reasons

Primary outcomes:
measure: crystalline lens tilt
timeFrame: 2020.4.30
measure: crystalline lens decentration
timeFrame: 2020.4.30
Secondary outcomes:
Other outcomes:
Locations:
city: Wenzhou
country: China
facility: Ophthalmology and Optometry Hospital
state: Zhejiang
Study officials:
References: