Clinical trial NCT02574182: Study of Motor Representations in Healthy Subjects and Amnestic MCI
Official title: Walking, Brain and Functional Magnetic Resonance Imaging Study of Motor Representations in Healthy Subjects and Amnestic MCI
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mild Cognitive Impairment
Keywords: Mild Cognitive Impairment
Magnetic Resonance Imaging
Lead sponsor: University Hospital, Angers
Sponsor class: OTHER_GOV
First posted: 2015-10-12
Enrollment: 97
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: * Healthy volunteers over 18 and under 40.
* Healthy volunteers over 60 years.
* MCI patient over 60 years

Brief summary: Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.

Detailed description: Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.

Eligibility criteria: Inclusion Criteria:

* Obtaining the signature of consent to participation in the study
* Age above 18 years
* Lack dementia as NICDS-ADRDA criteria
* Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI).
* Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae.
* No cons-indication for performing a brain MRI.
* Witennses, population of young (\<40 years)
* Witnesses ,population of older subjects (\> 60 years)
* Witnesses Lack of MCI
* MCI patients, criteria MCI criteria according to Dubois

Exclusion Criteria :

* Refusal of MRI.
* Contraindications to brain MRI.

Primary outcomes:
measure: Review and compare mapping cerebral activation in brain MRI
timeFrame: One day
Secondary outcomes:
measure: Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking.
timeFrame: One day
measure: Study of differences in terms of activation of brain mapping
timeFrame: One day
measure: study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI.
timeFrame: One day
measure: study of the potential effects on muscle activation, and autonomic nervous system
timeFrame: One day
Other outcomes:
Locations:
city: Angers
country: France
facility: University Hospital Angers
state: Pays De La Loire
Study officials:
affiliation: UH Angers
name: Michael Dinomais, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dinomais M, Minassian AT, Tuilier T, Delion M, Wilke M, N'Guyen S, Richard I, Aube C, Menei P. Functional MRI comparison of passive and active movement: possible inhibitory role of supplementary motor area. Neuroreport. 2009 Oct 7;20(15):1351-5. doi: 10.1097/WNR.0b013e328330cd43.
citation: Beauchet O, Allali G, Berrut G, Hommet C, Dubost V, Assal F. Gait analysis in demented subjects: Interests and perspectives. Neuropsychiatr Dis Treat. 2008 Feb;4(1):155-60. doi: 10.2147/ndt.s2070.
citation: Rimmer E, Wojciechowska M, Stave C, Sganga A, O'Connell B. Implications of the Facing Dementia Survey for the general population, patients and caregivers across Europe. Int J Clin Pract Suppl. 2005 Mar;(146):17-24. doi: 10.1111/j.1368-504x.2005.00482.x.
citation: Ogawa S, Lee TM, Nayak AS, Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med. 1990 Apr;14(1):68-78. doi: 10.1002/mrm.1910140108.
citation: Beauchet O, Allali G, Launay C, Herrmann FR, Annweiler C. Gait variability at fast-pace walking speed: a biomarker of mild cognitive impairment? J Nutr Health Aging. 2013 Mar;17(3):235-9. doi: 10.1007/s12603-012-0394-4.