louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02113423: Intensity Modulated Radiotherapy in Recurrent T1-2 Nasopharyngeal Carcinoma
Official title: Superiority of Intensity Modulated Radiotherapy in Recurrent T1-2 Nasopharyngeal Carcinoma
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nasopharyngeal Cancer Recurrent
Keywords: superiority, re-irradiation, IMRT, recurrent T1-2 NPC
Lead sponsor: Fujian Cancer Hospital
Sponsor class: OTHER_GOV
First posted: 2014-04-14
Enrollment: 168
Sex: ALL
Minimum age (years): 16
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The hypothesis of the study is to address the efficacy and toxicity profile of aforementioned four modalities for rT1-2 NPC.

Characters of the patients:

* list item one: 168 patients, median age 48 years (range 16-75 years） proven rT1-2 NPC were diagnosed
* list item two: Treated with four different irradiation modalities(3D-CRT,IMRT, BT , BT Combined 3D-CRT or IMRT).
* list item three: Median time to recurrence was 30 months (range 1-180months). The median follow-up time was 28 months (range, 4-135 months).

Detailed description: Objectives:

Recurrent T1-2 Nasopharyngeal Carcinoma (rT1-2) may be salvaged by 3D - CRT（3D-Conformal Radiotherapy）, IMRT（ Intensity Modulated Radiotherapy）, Brachytherapy (BT), BT combined 3D - CRT or IMRT . The aim of this study is to address the efficacy and toxicity profile of aforementioned four modalities for rT1-2 NPC.

Methods and Materials:

168 patients, median age 48 years (range 16-75 years） proven rT1-2 NPC were diagnosed and treated with four different irradiation modalities(3D-CRT,IMRT, BT , BT Combined 3D-CRT or IMRT) . Median time to recurrence was 30 months (range 1-180months). The median follow-up time was 28 months (range, 4-135 months).

Eligibility criteria: Inclusion Criteria:

* recurrent T1-2 nasopharyngeal carcinoma patients

Exclusion Criteria:

* non recurrent T1-2 nasopharyngeal carcinoma patients

Primary outcomes:
measure: all cause mortality
timeFrame: thirteen years
Secondary outcomes:
Other outcomes:
Locations:
city: Fuzhou
country: China
facility: Fujian Cancer Hospital Radiation Oncology Department
state: Fujian
Study officials:
affiliation: Department of Radiation Oncology, Cancer Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China
name: Jianji Pan, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00641823: Objective Functional Outcome Measures in Orthopedic Surgery Using Advanced Tracking Technologies
Official title: Objective Functional Outcome Measures in Orthopedic Surgery Using Advanced Tracking Technologies
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Orthopedic Disorders
Keywords: Orthopedic Surgical Procedures
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2008-03-24
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients suffering from osteoarthritis of the hips and knees, patient suffering from spinal claudication, and unimpaired controls

Brief summary: The proposed project will address the measurement and ramifications of out-of-home mobility problems in various orthopedic disorders in an innovative way, using advanced tracking technologies.


Eligibility criteria: Inclusion Criteria:

* Unwillingness to sign informed consent.

Exclusion Criteria:

* Pregnancy.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
Study officials:
References:
Clinical trial NCT06396923: The Effect of Music on Weight Lifters
Official title: The Effect of Listening to Music on Anaerobic Power in Elite Weightlifting Athletes
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Exercise Overtraining
Lead sponsor: KTO Karatay University
Sponsor class: OTHER
First posted: 2024-05-02
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The effects of listening to music on anaerobic power in elite weightlifting athletes will be examined.

Detailed description: The aim of the study was to investigate the effects of music listening on anaerobic power in elite weightlifting athletes.There is no study in the literature examining the relationship between music listening and anaerobic power in elite weightlifting athletes. Since our study will be the first to investigate the subject, we foresee that it is scientifically important and will shed light on future studies. In addition, national or international publications are planned after the study is completed.

Eligibility criteria: Inclusion Criteria:

* Being an elite weightlifter, volunteering for research

Exclusion Criteria:

* If you have any disability that may prevent the test, hearing problems

Primary outcomes:
measure: Wingate anaerobic power test
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Karatay
country: Turkey
facility: Mustafa Savaş Torlak
state: Eyalet/Yerleşke
Study officials:
References:
Clinical trial NCT03374423: Radiofrequency for Chronic Post-mastectomy Pain: is it Better to Target Intercostal Nerves or Corresponding Dorsal Root Ganglia?
Official title: Radiofrequency for Chronic Post-mastectomy Pain: is it Better to Target Intercostal Nerves (T2-T5) or Their Corresponding Dorsal Root Ganglia?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post-Mastectomy Chronic Pain Syndrome
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-12-15
Enrollment: 60
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: neuropathic pain can occur following any surgical procedure on the breast ..

Detailed description: chronic pain affects the daily lives of post-surgical breast cancer patients. many of these patients were undertreated for pain and generally obtained poor pain relief.treated patients with chronic thoracic segmental pain including patients with post-mastectomy pain syndrome by radiofrequency for dorsal root ganglion reported longterm pain relief.

Eligibility criteria: Inclusion Criteria:

* Patients with chronic post-mastectomy pain for at least 3 months post operatively.
* patients with visual analogue scale for pain score \> 4
* patients treated with more than one line of anti-neuropathic drugs.

Exclusion Criteria:

* patient refusal.
* coagulopathy.
* chest and back deformity.
* infection at the introduction site of the needle .

Primary outcomes:
measure: The intensity of pain
timeFrame: 1 month , 2 month and 3 month post-procedure
Secondary outcomes:
measure: The analgesics consumption
timeFrame: 1 month , 2 month and 3 month post-procedure
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Diab
state: Assuit
Study officials:
References:
citation: Stevens PE, Dibble SL, Miaskowski C. Prevalence, characteristics, and impact of postmastectomy pain syndrome: an investigation of women's experiences. Pain. 1995 Apr;61(1):61-68. doi: 10.1016/0304-3959(94)00162-8.
citation: Tasmuth T, von Smitten K, Hietanen P, Kataja M, Kalso E. Pain and other symptoms after different treatment modalities of breast cancer. Ann Oncol. 1995 May;6(5):453-9. doi: 10.1093/oxfordjournals.annonc.a059215.
citation: Stolker RJ, Vervest AC, Groen GJ. The treatment of chronic thoracic segmental pain by radiofrequency percutaneous partial rhizotomy. J Neurosurg. 1994 Jun;80(6):986-92. doi: 10.3171/jns.1994.80.6.0986.
Clinical trial NCT00223223: Levetiracetam for Neuroprotection Against Corticosteroid-induced Hippocampal Dysfunction: A Proof of Concept Study
Official title: Levetiracetam for Neuroprotection Against Corticosteroid-induced Hippocampal Dysfunction: A Proof of Concept Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Memory Loss Associated With Corticosteroid Use
Manic State Associated With Corticosteroid Use
Lead sponsor: University of Texas Southwestern Medical Center
Sponsor class: OTHER
Collaborators: name: UCB Pharma
First posted: 2005-09-22
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this research is to determine whether the memory impairment and manic symptoms (feelings of agitation, overexcitement or hyperactivity) typically seen in those on corticosteroid therapy is decreased with a seizure medication called levetiracetam compared to placebo (an inactive substance). Since increased levels of cortisol (the body's natural corticosteroid) in the body are frequently associated with memory impairment interventions that may prevent or reverse this are of great importance.

It is hypothesized that patients who are scheduled to receive prescription corticosteroid therapy who are given levetiracetam pretreatment will show lesser memory impairment and manic symptoms than those receiving placebo.


Eligibility criteria: Inclusion Criteria:

* Age 18-65 years
* Scheduled to receive a corticosteroid "burst" of at least 10 mg of prednisone equivalents and for at least 5 days duration
* English- or Spanish-speaking

Exclusion Criteria:

* History of allergic reaction or other contraindication to levetiracetam therapy
* Other unstable medical conditions (e.g. recent myocardial infarction, renal failure, diabetes with poor glycemic control)
* Pregnant or nursing women
* History of mental retardation, dementia or other severe cognitive disorders

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Dallas
country: United States
facility: The University of Texas Southwestern Medical Center
state: Texas
Study officials:
affiliation: UT Southwestern Medical Center at Dallas
name: E. Sherwood Brown, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04726423: Chronic Pain and Transcranial Direct Current Stimulation in Clinical Settings
Official title: Reduce Chronic Pain With Transcranial Direct Current Stimulation in Clinical Settings
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Chronic Pain
Keywords: transcranial direct current stimulation
physical exercise
physiotherapy
clinical settings
Lead sponsor: Université de Sherbrooke
Sponsor class: OTHER
First posted: 2021-01-27
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients that received tDCS sessions in clinical settings

Brief summary: Physical exercises and transcranial direct current stimulation (tDCS) are both known to reduce chronic pain in structured laboratory studies. The aim of this study is to assess the efficacy of this combined treatment in clinical settings.

Detailed description: Chronic pain patients who are going to the physiotherapy clinic to receive tDCS treatment sessions are evaluated in order to assess the efficacy of tDCS in clinical settings. Physiotherapists prescribe physical exercises adapted to the patients conditions. Patients performed their physical exercises every time they received a tDCS treatment, but were also recommended to continue their physical exercises program at home after completion of physiotherapy visits.

Concerning tDCS treatment, patients were encouraged to receive 1 tDCS session per day for 5 consecutive days.

Eligibility criteria: Inclusion Criteria:

* To have chronic pain

Exclusion Criteria:

* Contraindication to tDCS

Primary outcomes:
measure: Change in McGill pain Questionnaire
timeFrame: Baseline, 1 week, 1 month
measure: Change in Brief Pain Inventory
timeFrame: Baseline, 1 week, 1 month
measure: Change in Tampa Questionnaire
timeFrame: Baseline, 1 week, 1 month
measure: Change in Beck Depression Inventory
timeFrame: Baseline, 1 week, 1 month
measure: Change in Patient global impression of change
timeFrame: 1 week, 1 month
Secondary outcomes:
measure: Number of sessions received
timeFrame: Through study completion, an average of 5 days
measure: Side effect
timeFrame: Through study completion, an average of 5 days
Other outcomes:
Locations:
city: Sherbrooke
country: Canada
facility: Physio-Atlas
state: Quebec
Study officials:
affiliation: Université de Sherbrooke
name: Guillaume Leonard, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00666523: Effect of Phytalgic in Osteoarthritis (OA)
Official title: Randomized Double-Blind Study of Food Supplement Phytalgic on Symptoms of Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteoarthritis
Keywords: osteoarthritis, knee or hip
Lead sponsor: Université Victor Segalen Bordeaux 2
Sponsor class: OTHER
Collaborators: name: laboratoire Phythea, France
First posted: 2008-04-25
Enrollment: 81
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of the study is to test the effects of a herbal supplement, Phytalgic, on the symptoms of osteoarthritis of the knee or hip, in patients with OA using NSAIDs or analgesics on a regular basis.


Eligibility criteria: Inclusion Criteria:

* knee or hip osteoarthritis
* regular NSAIDs/analgesic treatment
* signed inform consent

Exclusion Criteria:

* incapacity to understand study
* irregular NSAID treatment

Primary outcomes:
measure: use of NSAIDs or analgesics
timeFrame: 3 months
Secondary outcomes:
measure: WOMAC function scale
timeFrame: 3 months
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: Dept of Pharmacology, U-Bordeaux2, BP36
Study officials:
affiliation: University of Bordeaux
name: Nicholas Moore, MD, PhD
role: STUDY_DIRECTOR
References:
citation: Jacquet A, Girodet PO, Pariente A, Forest K, Mallet L, Moore N. Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. Arthritis Res Ther. 2009;11(6):R192. doi: 10.1186/ar2891. Epub 2009 Dec 16.
Clinical trial NCT05394623: Prevalence and Burden of Hepatitis D Virus Infection in China Through Preoperative Examination Test (Predict Study)
Official title: Prevalence and Burden of Hepatitis D Virus Infection in China Through Preoperative Examination Test (Predict Study)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hepatitis D
Hepatitis B
Antibodies; Anti-D
RNA Virus Infections
Lead sponsor: The First Affiliated Hospital with Nanjing Medical University
Sponsor class: OTHER
Collaborators: name: Gilead Sciences
First posted: 2022-05-27
Enrollment: 5000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hepatitis D virus-infected patients in HBsAg positive population from 10 hospitals located in 5 diſferent geographical areas (North, South, East, West and Central) in China.

Brief summary: In China, there is no recommendation for Hepatitis D virus (HDV) screening, but the fact is estimated that one-third of the world's population of individuals with chronic Hepatitis B virus (HBV) infection live in China while we do not know the prevalence of co-infection of HBV/HDV in China. So far, no nationwide study has been undertaken to evaluate the epidemiology of hepatitis D, on the other hand, reports of HDV infection rate in different regions of China are not consistent because of the different detection methods and detection objects. Here, we plan to test HDV-Ab/RNA for 5000 HBsAg reactive samples from 10 major tertiary hospital and to know the prevalence and disease burden of HDV in China.


Eligibility criteria: Inclusion Criteria:

1. Positive HBV surface antigen (HBsAg)
2. Age 18 yeas and above

Exclusion Criteria:

1. Severe cardiac, renal, respiratory, hematological, or psychiatric illness.

Primary outcomes:
measure: HDV seroprevalence and HDV RNA prevalence amongst HBsAg positive carriers in China.
timeFrame: 3 months
Secondary outcomes:
measure: The distribution of HDV genotypes in China
timeFrame: 3 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03245723: Cardiac Function and Metabolism in Young Adults Born Premature (PET-MRI)
Official title: Cardiac Function and Metabolism in Young Adults Born Premature
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Infant,Premature
Keywords: premature adults
premature
premature lung function
premature cardiac function
MRI
PET
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
name: American Heart Association
First posted: 2017-08-10
Enrollment: 52
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Young adults born premature (some of them are registered on the National Lung Project) and Healthy Controls will undergo pulmonary function testing, cardiac positron emission tomography, and cardiac magnetic resonance imaging.
Primary purpose: OTHER

Brief summary: The purpose of this research is to determine the effect of premature birth on later heart function and metabolism.

Detailed description: The purpose of this study is to determine the effects of premature birth on cardiac function, cardiac metabolism, and oxidative stress in a cohort of young adults born prematurely using cardiac positron emission tomography/magnetic resonance imaging and mitochondrial respiration studies.

Eligibility criteria: Inclusion Criteria:

* National Lung Project Cohort only- birth weight \<1500g and a gestational age \<36 weeks
* Adults born preterm (Non-National Lung Project) only- gestational age ≤32 weeks OR birth weight ≤ 3lbs 5oz
* Healthy Controls only- No personal history of known cardiovascular or pulmonary disease

Exclusion Criteria:

* Metabolic Disorders that would affect Fludeoxyglucose uptake
* Contraindications to positron emission tomography and/or magnetic resonance imaging
* Pregnancy, if a female of child-bearing potential
* A personal history of Type I or Type II diabetes

Primary outcomes:
measure: Cardiac Glucose Uptake During Normoxic Rest (µg/Min)
timeFrame: Visit 1 (1 day)
measure: Change in Glucose Uptake From Normoxia to Hypoxia (µg/Min)
timeFrame: Visit 1 (1 day)
Secondary outcomes:
Other outcomes:
Locations:
city: Madison
country: United States
facility: UW Madison
state: Wisconsin
Study officials:
affiliation: The University of Wisconsin School of Medicine and Public Health
name: Kara N Goss, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06428123: Comparison of Efficacy of Mirror Therapy vs Mental Imagery in Reduction of Phantom Limb Pain in AKAP
Official title: Comparison of Efficacy of Mirror Therapy vs Mental Imagery in Reduction of Phantom Limb Pain in Above Knee Amputee Patients: A Comparative Study
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Phantom Limb Pain
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-05-24
Enrollment: 24
Sex: ALL
Minimum age (years): 12
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Limb amputation results in many types of pain, including localized pain at the stump and projected pain experienced by the patient in the location where the amputated limb used to be, known as phantom limb pain (PLP). The aim of this study is to determine the relative benefits of mirror therapy vs mental imagery in reduction of phantom limb pain. Randomized clinical trial study design will be followed.


Eligibility criteria: Inclusion Criteria:

* Both male and female gender with ages from 12 to 75 years (17).
* Individuals with a unilateral above-knee amputation (AKA) at least 6 months prior to the study.
* Experiencing phantom limb pain at least 3 months (16).

Exclusion Criteria:

* History of neurological disorders affecting pain perception or motor function (e.g., stroke, spinal cord injury, brain injury).
* Uncontrolled diabetes or other medical conditions that could affect healing or participation in the study.
* Pregnancy or breastfeeding.

Primary outcomes:
measure: The Numeric Rating (NRS)
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Azra Naheed Medical College, Superior University
state: Punjab
city: Lahore
country: Pakistan
facility: Ghurkee Hospital
state: Punjab
Study officials:
References:
Clinical trial NCT01973023: Stroke's Gait Pattern Modifications of Induced by Repeated BTI
Official title: Improvement of Chronic Stroke Patients Gait Pattern Following Repetitive Multifocal Botulinum Toxin Injection Sessions in Paretic Lower Limb: an Observational Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Effect of Repeated Botulinum Toxin Injection on Gait Pattern in Stroke Patients
Keywords: botulinum toxin injection
stroke
3D motion analysis
gait pattern
Lead sponsor: Centre d'Investigation Clinique et Technologique 805
Sponsor class: OTHER
First posted: 2013-10-31
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: STROKE PATIENTS

Brief summary: Chronic stroke patients exhibit gait pattern alterations which are mainly due to spasticity and treated with repetitive multifocal botulinum toxin injection(BTI). Several studies demonstrated that single BTI-session in a single muscle of paretic lower limb(LL) improved kinematic gait parameters(GP) but surprisingly none of them assessed the effects of repetitive multifocal BTI on patient's gait pattern and their duration.

The aim was to evaluate the impact of repetitive multifocal BTI-sessions on GP of chronic stroke patients. To that end, gait of patients has been compared using 3D-gait analysis after at least 2 consecutive BTI sessions.

Detailed description: All the patients will be tretaed with BTI . these injections will be performed under electrical stimulation control (\~5mA). The dose, the number of site of injection per muscle is at the discretion of the physician according to patients' needs and physicians' routine clinical practice. The dilution the most commonly used will depend on the type of BoNT-A (BOTOX®, XEOMIN® or DYSPORT®) and was 100 U for 2.5ml (BOTOX® and XEOMIN®) or 500 U for 2.5 ml (Dysport®).

Eligibility criteria: Inclusion Criteria:

-\>18 years

* a single hemispheric cerebral vascular lesion more than 6 months previously
* able to walk 10 meters without any assistance
* having benefited of at least 2 consecutive BTI sessions, second 3D gait analysis performed at least 3 months after the last BTI.

Exclusion Criteria:

* patient's refusal to participate to the study
* Inability to read the selected text
* Inability to cooperate
* No affiliation to social security

Primary outcomes:
measure: kinematics gait parameters
timeFrame: 3h
Secondary outcomes:
measure: spatiotemporal gait parmeters
timeFrame: 3h
Other outcomes:
Locations:
city: Garches
country: France
facility: Hopital Raymond Poincare
Study officials:
affiliation: HOPITAL RAYMOND POINCARE-GARCHES
name: ROCHE Nicolas, MDPHD
role: PRINCIPAL_INVESTIGATOR
References: