Clinical trial NCT06449976: Application and Clinical Evaluation of Longitudinal Chromatic Aberration Technique in Ophthalmology
Official title: Application and Clinical Evaluation of Longitudinal Chromatic Aberration Technique in Ophthalmology
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Longitudinal Chromatic Aberration
Blue Light Defocus Manipulation
Keywords: Longitudinal chromatic aberration
Reading efficiency
Visual function
Visual fatigue
Fundus blood flow
Axial length
Total refraction difference value
Lead sponsor: Beijing Tongren Hospital
Sponsor class: OTHER
First posted: 2024-06-10
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: This study is designed with a total of four groups, where participants will sequentially and randomly undergo all the intervention procedures.
Primary purpose: PREVENTION

Brief summary: Our study aims to delve into the effects of shifting the focal point of blue light from video or text displayed on a terminal screen forward on the axial length of the eye, ocular blood flow, visual fatigue, and visual function, that is, its relationship with Video Display Terminal (VDT) syndrome and myopia. By examining the decoding ability of the adult subjects' retina to the clarity of the signal, we will attempt to develop a novel, non-invasive strategy to curb the elongation of the eyeball associated with myopia. Concurrently, we will also focus on the pathophysiological mechanisms underlying VDT syndrome and explore its potential link to the progression of myopia, providing new scientific evidence for the prevention and treatment of this ocular condition. This research is expected to provide robust support for addressing the global issue of myopia and the health challenges posed by VDT syndrome. Ultimately, by integrating global eye health issues with the challenges brought about by VDT syndrome, we will propose intervention and prevention strategies, offering new insights for the advancement of ophthalmology and public health sectors, thereby promoting visual acuity and ocular health for the population.


Eligibility criteria: Inclusion Criteria:

1. Adult population, regardless of gender
2. Refractive error is less than or equal to -2.5D and both eyes achieve corrected visual acuity of 0.8 or higher.
3. Normal intraocular pressure with no organic pathology.
4. No apparent symptoms of dry eye.
5. Willing to cooperate to complete all the tests.
6. Voluntarily signing the informed consent form.

Exclusion Criteria:

1. Individuals with strabismus and amblyopia exist.
2. Suffering from congenital eye conditions such as congenital cataracts or congenital retinal diseases.
3. Those who have undergone intraocular surgery (such as cataract removal, intraocular lens implantation, etc.).
4. Individuals with refractive media opacity (such as corneal lesions, lens opacity, etc.).
5. Abnormal intraocular pressure (IOP) (IOP \< 10 mmHg or IOP \> 21 mmHg, or a bilateral IOP difference of ≥5 mmHg).
6. Only one eye meets the inclusion criteria.
7. Active corneal infections such as bacterial, fungal, viral, or other acute or chronic anterior segment inflammations.
8. Currently using medications that may lead to dry eye or affect vision and corneal curvature.
9. Other ocular conditions, such as dacryocystitis, eyelid disorders and abnormalities, abnormal intraocular pressure, and glaucoma.
10. Unable to undergo regular eye examinations.

Primary outcomes:
measure: Ocular Fundus Blood Flow
timeFrame: The total duration of the visual task is 50 minutes. Retinal blood flow is measured for each subject at 0 minutes, 25 minutes, and 50 minutes during the visual task, resulting in a
Secondary outcomes:
measure: Visual fatigue
timeFrame: Each participant will complete the visual fatigue questionnaire, followed immediately by a VEP task, and then re-assess visual fatigue immediately afterward. This sequence will occur twice per group, totaling eight assessments per participant.
measure: Measurement of Accommodative Sensitivity with Flip-Chart Post-VEP Tasks
timeFrame: Each participant will have five measurements: a baseline, and four post-VEP tasks, with immediate flipchart tests after each task.
measure: Blink Frequency
timeFrame: Blink frequency 3 minutes after the start of each visual evoked task and 3 minutes before the end.
measure: Reading efficiency
timeFrame: The test was recorded 5 minutes after the start and 10 minutes before the end.
measure: AC/A Ratio Measurement Post-VEP Tasks
timeFrame: Each participant will undergo five AC/A ratio measurements: at baseline and immediately after each of four VEP tasks.
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Tongren Hospitol, Capital Medical University
state: Beijing
Study officials:
References: