louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06249646: Contained Hepatic Vascular Injuries Following Liver Trauma
Official title: Contained Hepatic Vascular Injuries Following Liver Trauma: a Retrospective Monocentric Study and Review of the Literature
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hepatic Injury
Liver Injury
Pseudoaneurysm
Lead sponsor: Centre Hospitalier Universitaire de Nice
Sponsor class: OTHER
First posted: 2024-02-08
Enrollment: 318
Sex: ALL
Minimum age (years): 15
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Liver trauma was identified on post-injury imaging evaluation or operative exploration. Admission following the trauma could either be directly from the trauma location or be a transfer from another regional hospital. Upon admission, if the patient was stable or stabilized following intensive care management, a contrast full-body CT scan was performed. Non-operative management was the primary treatment when possible. If the patient was unstable, primary surgical management was required. Surgical management could include sole exploration, hemostatic techniques, hepatic packing, drainage, or hepatectomy. If the investigators performed a damage control laparotomy with perihepatic packing, a second surgery was performed for definitive treatment after 24-48 h. In such cases, a contrast full-body CT scan was performed after the surgery. If a CT scan was not performed in the first 24 hours, the patient was not included in this study.

Brief summary: Background: For thirty years, a major shift in the management of liver trauma has been seen. Contained hepatic vascular injuries (CHVI), including pseudo aneurysms and arteriovenous fistula, are often feared due to their risk of secondary bleeding. Nonetheless, knowledge of CHVI is scarce and no guidelines on their management have been set. The investigators aimed to validate the risk factors of CHVI, identify associated morbidities, and establish a management protocol.

Study Design: A retrospective study on 318 liver trauma from a level 1 trauma center over the last 15 years, comparing the presence or not of CHVI. Univarious and multivarious analyses were performed. A comparison of the management of CHVI was also performed.


Eligibility criteria: Inclusion Criteria:

* presence of liver trauma
* age above 15 years old
* a full contrast abdominal CT

Exclusion Criteria: none

Primary outcomes:
measure: Identification of a % of CHVI on the initial or the follow-up Chest-Thorax scans.
timeFrame: 6 months
Secondary outcomes:
measure: Investigate the management of CHVI following liver trauma.
timeFrame: 6 months
Other outcomes:
Locations:
city: Nice
country: France
facility: CHU de Nice
state: Alpes Maritimes
Study officials:
References:
Clinical trial NCT02525146: Birmingham Access to Care Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: HIV Infection
HIV Care Loss to Followup
Keywords: HIV
Reengagement in HIV Care
ARTAS
Lead sponsor: University of Alabama at Birmingham
Sponsor class: OTHER
Collaborators: name: Birmingham AIDS Outreach
name: Johns Hopkins University
name: AIDS United
First posted: 2015-08-17
Enrollment: 170
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether a modified form of the ARTAS (Antiretroviral Treatment and Access to Services) intervention, adapted for HIV patients who have fallen out of care, can be successful in re-engaging patients in care and reducing HIV-1 viral load.


Eligibility criteria: Inclusion Criteria:

* HIV patient with at least one primary care appointment since 1/1/10 but currently lost to follow-up defined as 1) currently out of care for greater than 7 months or 2) does NOT have two or more completed clinic visits separated by three or more months in time during a 12-month observation period (HRSA-HAB measure of retention in care) or 3) has 2 or more "no shows" - scheduled visits for which the patient has not arrived or canceled - in the past 12 months.
* 19 years or older
* Be able and willing to provide informed consent
* Be willing to provide locator information
* Be willing to sign a HIPAA authorization form/medical record release form to facilitate medical record abstraction
* Report living in the vicinity
* Be able to communicate in English.

Exclusion Criteria:

* Not meeting one of the above inclusion criteria
* Have significant cognitive or developmental impairment to the extent that they are unable to provide informed consent
* Incarcerated at the time of potential enrollment
* Are terminated via site PI decision

Primary outcomes:
measure: Change in HIV-1 Viral Load from Baseline to 12-month Followup
timeFrame: Baseline and 12-month Followup
Secondary outcomes:
measure: Re-Engagement in Care: Post-Enrollment Linkage Visit + Meeting HRSA-HAB Guidelines for Retention in Care
timeFrame: 12-month
Other outcomes:
Locations:
Study officials:
affiliation: University of Alabama at Birmingham, 1917 HIV Clinic
name: James L Raper, PhD, CRNP, JD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Alabama at Birmingham
name: Michael J Mugavero, MD, MHSc
role: STUDY_DIRECTOR
affiliation: University of Alabama at Birmingham
name: David S Batey, PhD, MSW, LCSW
role: STUDY_DIRECTOR
References:
Clinical trial NCT05803746: PD-L2 Targeting Nanobody Radiotracer for PET Imaging of Solid Tumor
Official title: PD-L2 Targeting Nanobody Radiotracer for PET Imaging of Solid Tumor
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Lung Cancer
Colorectal Cancer
Lead sponsor: Peking University Cancer Hospital & Institute
Sponsor class: OTHER
First posted: 2023-04-07
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The objective of this study is to construct a noninvasive approach using 68Ga- Mirc415 PET/CT to detect the PD-L2 expression of tumor lesion in patients with colorectal cancer, lung cancer and other solid tumor to identify patients benefiting from anti-PD-(L)1 treatment.


Eligibility criteria: Inclusion Criteria:

1. Aged 18-75, male and female, with ECOG score of 0 or 1;
2. Subjects with head and neck tumors, lung cancer, esophageal cancer, breast cancer, ovarian cancer, cholangiocarcinoma, colorectal cancer, gastric cancer, pancreatic cancer, melanoma, bone or soft tissue sarcoma, solid tumors or suspected tumor subjects who intend to undergo pathological tissue biopsy or receive tumor surgical treatment in the near future (within 2 months);
3. The expected survival was more than 26 weeks;
4. Blood routine test, liver and kidney function meet the following standards: blood routine: WBC \>= 4.0 x 10\^9/L or neutrophil \>= 1.5 x 10\^9/:, PLT \>= 100 x 10\^9 / L, Hb \>= 90g / L; Pt or APTT \<= 1.5 upper limit of normal value; liver and kidney function: total bilirubin \<= 1.5 x ULT (upper limit of normal value), ALT / AST \<= 2.5 upper limit of normal value or \<= 5 x ULT (subject with liver metastasis), ALP \<= 2.5 upper limit of normal value (if bone metastasis or liver metastasis exists, ALP \<= 4.5 upper limit of normal value); BUN \<= 1.5 x ULT, SCR \<= 1.5 x ULT;
5. According to RECIST1.1, there was at least one measurable target lesion;
6. Women must take effective contraceptive measures during the study period and within 6 months after the end of the study; men should agree to use contraceptive measures during the study period and within 6 months after the end of the study period;
7. Understand and sign informed consent voluntarily with good compliance.

Exclusion Criteria:

1. The function of liver and kidney was seriously abnormal;
2. Preparation for pregnant, pregnant and lactating women;
3. Inability to lie flat for half an hour;
4. Suffering from claustrophobia or other mental disorders; 5) Other researchers considered it unsuitable to participate in the trial. -

Primary outcomes:
measure: MPR
timeFrame: [Time Frame: After 2-4 cycles of immunotherapy (each cycle is 28 days)]
Secondary outcomes:
measure: PFS
timeFrame: 2 years
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Cancer Hospital
Study officials:
References:
Clinical trial NCT06261346: Plasma Rich in Growth Factors in Corneal Endothelial Transplantation
Official title: Safety and Efficacy of Brief Intraoperative Corneal Endothelial Graft Incubation in Plasma Rich in Growth Factors (PRGF) for Reducing Postoperative Endothelial Cell Loss
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Fuchs' Endothelial Dystrophy
Corneal Edema
Lead sponsor: University of Miami
Sponsor class: OTHER
Collaborators: name: Florida lions eye bank
First posted: 2024-02-15
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to determine the safety and efficacy of brief intraoperative corneal endothelial graft incubation in plasma rich in growth factors (PRGF) for reducing postoperative endothelial cell loss.


Eligibility criteria: Inclusion Criteria:

* undergoing endothelial keratoplasty (DSEK or DMEK) at the Bascom Palmer Eye Institute or Price Vision Group, using corneal graft tissue within 14 days of preservation

Exclusion Criteria:

* History of corneal transplantation in the study eye, Best corrected visual acuity (BCVA) worse than 20/40 in the contralateral eye, systemic immunosuppression, previous intraocular surgical procedures (other than cataract surgery) such as glaucoma tubes or silicone oil.

The following special populations will be excluded.

* Adults unable to consent
* Pregnant women
* Prisoners

Primary outcomes:
measure: Change in endothelial cell percentage
timeFrame: Baseline, 6 months
Secondary outcomes:
measure: Corneal endothelial cell density
timeFrame: Up to 12 months
measure: Change in Endothelial cell density
timeFrame: Baseline, up to 12 months
measure: Visual acuity measured by snellen chart
timeFrame: Up to 12 months
measure: Number of re-bubbling for graft attachment
timeFrame: Up to 2 months
Other outcomes:
Locations:
city: Miami
country: United States
facility: Bascom Palmer Eye Institute
state: Florida
city: Indianapolis
country: United States
facility: Price Vision Group
state: Indiana
Study officials:
affiliation: Bascom Palmer Eye Institute
name: Alfonso L Sabater, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01015846: Ultrasound Assessment During Exercise
Official title: Assessment of Transverse Abdominis Muscle Function Associated With Stabilization Exercises in Low Back Pain Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Low Back Pain
Keywords: Core
Redcord
RUSI
low back
Lead sponsor: University of Virginia
Sponsor class: OTHER
First posted: 2009-11-18
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluates the ability of the transverse abdominis (TrA) to contract during and after two different types of exercise - either sling based exercise or traditional core stability exercise. The TrA is measured by real time ultrasound imaging. The investigators hypothesized that the sling based exercise would activate the TrA to a greater degree and that there would be a greater activation after the exercise.


Eligibility criteria: Inclusion Criteria:

* Low back pain with stabilization classification

Exclusion Criteria:

* Fractures, neurological condition

Primary outcomes:
measure: TrA activation ratio measured by RUSI
timeFrame: Pre - during - post exercise during a single day
Secondary outcomes:
Other outcomes:
Locations:
city: Charlottesville
country: United States
facility: University of Virginia
state: Virginia
Study officials:
affiliation: University of Virginia
name: Susan Saliba
role: PRINCIPAL_INVESTIGATOR
References:
citation: Grooms DR, Grindstaff TL, Croy T, Hart JM, Saliba SA. Clinimetric analysis of pressure biofeedback and transversus abdominis function in individuals with stabilization classification low back pain. J Orthop Sports Phys Ther. 2013 Mar;43(3):184-93. doi: 10.2519/jospt.2013.4397. Epub 2012 Nov 16.
Clinical trial NCT05902546: Effect of HIIT Vs Moderate Intensity Aerobic Exercise on Insulin Resistance in Type 2 DM
Official title: Effect of High Intensity Interval Training Versus Moderate Intensity Aerobic Exercise on Insulin Resistance in Type 2 Diabetes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetes Mellitus
Insulin Resistance
Lead sponsor: Badr University
Sponsor class: OTHER
Collaborators: name: Ahmed Maher Teaching Hospital
First posted: 2023-06-15
Enrollment: 80
Sex: ALL
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparing between the efficacy of high intensity interval training and moderate intensity aerobic exercises on insulin resistance in type 2 Diabetes Mellitus.

Detailed description: The study aims at differentiating between high intensity interval training and moderate intensity continuous aerobic exercise in terms of their effect of Insulin resistance in patients diagnosed with type 2 Diabetes Mellitus. All participants will have lab analysis for Serum Homa-IR prior to intervention and after 1 month of treatment.

Eligibility criteria: Inclusion Criteria:

* Type 2 Diabetes Mellitus Patients.
* Diagnosed for more than 1 years at the time of the study.
* Patients with fair control of blood glucose using hypoglycemic drugs

Exclusion Criteria:

* Type 1 (Insulin Dependant) Diabetes Mellitus patients.
* Patients with disability that can't perform exercises.
* Patient with known Cardiovascular diseases.
* Patients with kidney/liver diseases

Primary outcomes:
measure: Insulin Resistance (Homa-IR)
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ahmed Maher Teaching Hospital
city: Cairo
country: Egypt
facility: Elamahaba Specialized Charity Polyclinics
city: Cairo
country: Egypt
facility: Trust Physical Therapy Center and Rehabilitation
city: Cairo
country: Egypt
facility: Badr University in Cairo, Faculty of Physical Therapy, Outpatient Clinic
Study officials:
affiliation: Dept of Internal Medicine & geriatric, Faculty of Physical Therapy, Badr University in Cairo, Egypt.
name: Mina AG Elias, Dr.
role: PRINCIPAL_INVESTIGATOR
affiliation: Dept of Cardiopulmonary & internal medicine rehab, Faculty of Physical Therapy, Galala Univ; Egypt.
name: Khaled M Mounir, Dr.
role: STUDY_CHAIR
References:
Clinical trial NCT06460246: Pulse Oximeter Accuracy During Stable Hypoxia Plateaus
Official title: Pulse Oximeter Accuracy During Stable Hypoxia Plateaus
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: Acurable Ltd.
Sponsor class: INDUSTRY
First posted: 2024-06-14
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This project aims to test the accuracy of pulse oximeters in the range of arterial HbO2 saturations from 100% down to 70%.

Detailed description: This project aims to test the accuracy of pulse oximeters in the range of arterial HbO2 saturations from 100% down to 70%. This is done by comparing the pulse oximeter reading during brief, steady state hypoxia plateaus with a gold-standard measurement of blood oxyhaemoglobin saturation.

Eligibility criteria: Inclusion Criteria:

* Male or female, aged \>= 18 and \< 50.
* Subject in good general health with no evidence of any medical problems.
* Subject is fluent in both written and spoken English.
* Subject has provided informed consent and is willing to comply with the study procedures.

Exclusion Criteria:

* Subject is obese (BMI \> 35).
* Subject has a known history of heart disease, lung disease, kidney, or liver disease.
* Diagnosis of asthma, sleep apnea, or use of CPAP.
* Subject has diabetes.
* Subject has a clotting disorder.
* Subject has hemoglobinopathy or history of anemia, per subject report or the first blood sample, that in the opinion of the investigator, would make them unsuitable for study participation.
* Subject has any other serious systemic illness.
* Subject is a current smoker.
* Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators would interfere with the sensors working correctly.
* Subject has a history of fainting or vasovagal response.
* Subject has a history of sensitivity to local anesthesia.
* Subject has a diagnosis of Raynaud's disease.
* Subject has unacceptable collateral circulation based on exam by the investigator (Allen's test).
* Subject is pregnant, lactating, or trying to get pregnant.
* Subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures.
* Subject has any other condition, which in the opinion of the investigators would make them unsuitable for the study.

Primary outcomes:
measure: Performance of the pulse oximeters against corresponding arterial blood oxygen saturation.
timeFrame: 1-4 hours
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: Vital Signs Research Group, L.L.C.
state: California
Study officials:
References:
Clinical trial NCT05815446: Non Contrast CT in Acute Appendicitis
Official title: Diagnostic Accuracy of Non-Contrast Computed Tomography in Correlation With Ultrasound in Detecting Acute Appendicitis in Adults
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Appendicitis
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-04-18
Enrollment: 78
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study will be applied upon all patient referred from the emergency ward with clinical suspicious of acute appendicitis during the period from April 2023 to December 2023. Patients should fulfill the following criteria.

Brief summary: To evaluate Diagnostic accuracy of Non-contrast CT in correlation with ultrasound in diagnosis of acute appendicitis in adults

Detailed description: Acute appendicitis is a prevalent cause of abdominal pain, with an estimated lifetime risk of 7 to 9%.\[1\] Diagnosing appendicitis on CT has a sensitivity and specificity of 87% and 76%, respectively. Classically, diagnosis of acute appendicitis is by identifying an enlarged appendix (greater than 6 mm in diameter) .

Some studies suggest using a cut-off value of over 7 mm to improve the prognostic capability of CT.

On the other hand, appendicitis is regularly diagnosed using radiology studies. In fact, imaging is often the deciding factor between operative and non-operative management. Though the diagnosis can be clinical following a thorough history and physical, imaging is regularly employed to confirm the diagnosis in question. The most commonly used radiographic study is the CT scan, given its speed, sensitivity, and specificity. US is also relatively useful modality to diagnose acute appendicitis, it has its limitations. Ultrasound is highly operator dependent and tends to work best on individuals with less fat and muscle content in their abdomen (i.e., children). Currently, the negative appendectomy is less than 12% in men but can be up to 33% in women; accurate imaging studies could reduce the number of unnecessary surgeries performed on patients. It is, therefore, essential to know which study will provide the clinician with the most accurate information for their specific clinical scenario.

Eligibility criteria: Inclusion Criteria:

* Adult patient (male or female) with clinical suspicion of acute appendicitis .

Exclusion Criteria:

* pregnant ladies and patients with history of appendectomy

Primary outcomes:
measure: accuracy of non contrast CT in correlation with ultrasound in acute appendicitis .
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Cohen CI. A case report: periodontal surgery in Parkinsonism utilizing intravenous sedation. N Y State Dent J. 1978 Jan;44(1):19. No abstract available.
citation: Drazen JM. Asthma therapy with agents preventing leukotriene synthesis or action. Proc Assoc Am Physicians. 1999 Nov-Dec;111(6):547-59. doi: 10.1046/j.1525-1381.1999.t01-1-99242.x.
Clinical trial NCT05385146: Effect of Chan-Chuang Qigong With Breathing Meditation on Quality of Life in Patients With Breast Cancer
Official title: Effect of Chan-Chuang Qigong With Breathing Meditation on Quality of Life in Patients With Breast Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Breast Cancer
Quality of Life
Intraoperative Awareness
Lead sponsor: Chang Gung University of Science and Technology
Sponsor class: OTHER
Collaborators: name: Taipei Hospital, Taiwan
First posted: 2022-05-23
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: randomized
Primary purpose: PREVENTION

Brief summary: The aim of this study was to evaluate the effect of the 15 weeks Chan-Chuang qigong program with breathing meditation on quality of life and interoceptive awareness in patients with breast cancer during chemotherapy.

Detailed description: Cancer is the leading cause of death globally, and breast cancer is the number one threat to women's health worldwide. Chemotherapy is the main adjunctive treatment for breast cancer. However, chemotherapy increasingly being employed in the management of breast cancer patients will cause physical and psychological discomfort as reported. The aim of this study was to evaluate the effect of Chan-Chuang qigong therapy with breathing meditation on quality of life and interoceptive awareness in breast cancer patients. This was a randomized controlled trial. Participants were randomly assigned to the qigong group who received Chan-Chuang qigong therapy with breathing meditation for 15 weeks, and the control group who received routine care. The outcomes were measured by using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Multidimensional Assessment of Interoceptive Awareness (MAIA).

Eligibility criteria: Inclusion Criteria:

1. aged ≥20
2. diagnosed with breast cancer (stages I and II)
3. before receiving chemotherapy
4. conscious clear to communicate.

Exclusion Criteria:

1. severe cardiopulmonary, liver or kidney dysfunction
2. the original law of qigong cases.

Primary outcomes:
measure: Change in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30) scores
timeFrame: baseline, Week 6, Week 15.
measure: Change in Multidimensional Assessment of Interoceptive Awareness (MAIA-C) scores
timeFrame: baseline, Week 15
Secondary outcomes:
Other outcomes:
Locations:
city: Taoyuan
country: Taiwan
facility: Chang Gung University of Science and Technology
Study officials:
References: