Clinical trial NCT04957082: Culturally-Targeted COVID-19 Communication and SARS-CoV-2 Antibody Testing Evaluation and Uptake
Official title: Culturally-targeted Communication to Promote SARS-CoV-2 Antibody Testing in Saliva: Enabling Evaluation of Inflammatory Pathways in COVID-19 Racial Disparities
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: SARS-CoV2 Infection
Keywords: SARS-CoV-2
COVID-19
Health Disparities
Health Communication
Antibodies
Lead sponsor: Michigan State University
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
name: Johns Hopkins University
First posted: 2021-07-12
Enrollment: 666
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Intervention model description: Design is partial factorial. All white participants and half of African American participants will receive general video education/messaging. Half of African American participants will be assigned to an intervention condition that includes culturally-targeted information about SARS-CoV-2 antibody testing.
Primary purpose: SCREENING

Brief summary: This disparities-focused study seeks to evaluate communication strategies for better encouraging understanding and uptake of salivary SARS-CoV-2 antibody testing among African Americans residing in Flint, Michigan. This iteration will consider individuals recruited from the Flint Registry and assess willingness to participate in a drive-up saliva sample collection taking place at a central location in Flint, Michigan.

Detailed description: African Americans develop and die from SARS-CoV-2 infection more than any other racial group in the United States, including in majority African American cities such as Flint, Michigan. Addressing these disparities may be aided by SARS-CoV-2 antibody testing. However, African Americans may be reluctant to partake in conventional antibody testing programs due to medical mistrust and experiences with racism. This study seeks to evaluate communication strategies for better encouraging understanding and uptake of salivary SARS-CoV-2 antibody testing. The central hypothesis is that African-Americans will be more receptive to antibody testing when benefits and limitations are communicated in a culturally effective manner. Our clinical trial aims are to 1) develop and compare effects of a general versus culturally-targeted video about antibody testing on African American and White Flint residents' antibody testing attitudes and uptake; 2) identify and compare effects of a general versus culturally-targeted video on activation of medical mistrust and racism-related cognition among African Americans when considering antibody testing. In collaboration with clinical and community partners, we have prepared and will evaluate general and culturally-targeted video tutorials about SARS-CoV-2 antibody testing. These brief videos will be distributed to the Flint community through the Flint Registry - a highly visible local health resource exchange. We will furnish an opportunity to engage salivary antibody screening and measure willingness to participate. In this study iteration, we will consider willingness to participate in a drive-up saliva sample collection that is taking place at a central location in Flint, Michigan.

Eligibility criteria: Inclusion Criteria:

* African American or White, 18 or older, and enrolled in the Flint Registry

Exclusion Criteria:

* All who do not meet inclusion criteria.

Primary outcomes:
measure: Number (Percentage) of Participants Requested to Participate in Saliva-based SARS-CoV-2 Antibody Testing
timeFrame: Immediately following didactic study portion and health communication randomization on day 1.
measure: Number (Percentage) of Participants Who Requested Saliva-based SARS-CoV-2 Antibody Testing Participated in the Testing.
timeFrame: 8 weeks from the day of consenting to participate in the salivary-based SARS-CoV-2 antibody testing
measure: SARS-CoV-2 Antibody Testing Attitudes
timeFrame: Immediately following didactic study portion and health communication randomization on day 1.
measure: SARS-CoV-2 Antibody Testing Normative Beliefs
timeFrame: Immediately following didactic study portion and health communication randomization on day 1.
measure: Antibody Testing Perceived Behavioral Control
timeFrame: Immediately following didactic study portion and health communication randomization on day 1.
measure: Antibody Testing Intentions
timeFrame: Immediately following didactic study portion and health communication randomization on day 1.
measure: Antibody Testing Anticipatory Racism
timeFrame: Immediately following didactic study portion and health communication randomization on day 1.
Secondary outcomes:
Other outcomes:
Locations:
city: Flint
country: United States
facility: Flint Journal Building
state: Michigan
Study officials:
References: