Clinical trial NCT06961838: The Effect of Inspiratory Muscle Training With Substance Use Disorder
Official title: The Effect of Inspiratory Muscle Training With Substance Use Disorder
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Substance Abuse Disorder
Exercise
Pulmonary Function
Rehabilitation
Keywords: Substance Use Disorder
Exercise
Rehabilitation
Pulmonary Function
Muscle Training
Lead sponsor: Uskudar University
Sponsor class: OTHER
First posted: 2025-05-08
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim was to investigate the effectiveness of inspiratory muscle training on dyspnoea, pulmonary function, respiratory muscle strength, cough capacity, functional exercise capacity, substance craving, depression, anxiety and quality of life in individuals with substance use disorder.

Detailed description: In recent years, substance use has increased among young people in our country, and studies investigating the negative effects of substances on pulmonary health have also increased. It has been emphasized in the literature that the most appropriate features should be determined for the exercise program in the treatment of individuals with SUD. Although studies in the literature have reported that substance use affects respiratory functions and creates a restrictive or obstructive pattern, no study investigating the effects of inspiratory muscle training has been found in the literature. To our knowledge, this study is the first to examine the effects of inspiratory muscle training on respiratory function in individuals with SUD. In our study, it was assumed that inspiratory muscle training could be a simple and inexpensive technique to improve dyspnea, respiratory functions, respiratory muscle strength, cough capacity, and exercise capacity in individuals with SUD, reduce substance cravings, increase quality of life, and reduce depression and anxiety, thus making it suitable for routine clinical use. The aim was to examine the effectiveness of inspiratory muscle training on dyspnea, respiratory functions, respiratory muscle strength, functional exercise capacity, substance craving, anxiety, depression, and quality of life in individuals with substance use disorders.

Eligibility criteria: Inclusion Criteria:

* Being older than 18 years

  * Meeting the current Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria for Substance Use Disorder
  * Receiving inpatient treatment
  * Substance use for more than one year
  * Being able to follow simple instructions
  * Not having any visual and auditory pathology
  * Being able to cooperate with the devices used.

Exclusion Criteria:

* Failure to comply with the treatment and assessment program
* Participation in a structured physiotherapy/exercise program in the last 6 months
* Presence of current psychotic symptoms
* Presence of any physical disability or medical problem
* Presence of respiratory system problems such as asthma and tuberculosis and infectious health problems (e.g. HIV, hepatitis B).

Primary outcomes:
measure: Dyspnea
timeFrame: 4 weeks
measure: Respiratory Functions (FEV1)
timeFrame: 4 weeks
measure: Respiratory Functions (FVC)
timeFrame: 4 weeks
measure: Respiratory Functions (FEV1/FVC)
timeFrame: 4 weeks
measure: Respiratory Functions (FEF 25-75%)
timeFrame: 4 weeks
measure: Respiratory Functions (PEF)
timeFrame: 4 weeks
measure: Respiratory Muscle Strength
timeFrame: 4 weeks
measure: Cough Capacity
timeFrame: 4 weeks
measure: Functional exercise capacity
timeFrame: 4 weeks
Secondary outcomes:
measure: Penn Substance Craving Scale
timeFrame: 4 weeks
measure: Health-related quality of life
timeFrame: 4 weeks
measure: Anxiety and Depression
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Üsküdar University
Study officials:
References:
citation: Sivasothy P, Brown L, Smith IE, Shneerson JM. Effect of manually assisted cough and mechanical insufflation on cough flow of normal subjects, patients with chronic obstructive pulmonary disease (COPD), and patients with respiratory muscle weakness. Thorax. 2001 Jun;56(6):438-44. doi: 10.1136/thorax.56.6.438.
citation: Black LF, Hyatt RE. Maximal respiratory pressures: normal values and relationship to age and sex. Am Rev Respir Dis. 1969 May;99(5):696-702. doi: 10.1164/arrd.1969.99.5.696. No abstract available.
citation: Laszlo G. Standardisation of lung function testing: helpful guidance from the ATS/ERS Task Force. Thorax. 2006 Sep;61(9):744-6. doi: 10.1136/thx.2006.061648.