Clinical trial NCT05122312: Comparative Study on the Efficacy of OliNano SEAL and Curodont D' Senz in Treatment of Dentin Hypersensitivity
Official title: Comparative Study on the Efficacy of OliNano SEAL and Curodont D' Senz in Treatment of Dentin Hypersensitivity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Dentin Hypersensitivity
Keywords: OLiNano SEAL
Curodont D'Senz
Dentin Hypersensitivity
Dye penetration
Dentin permeability
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2021-11-16
Enrollment: 70
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A total of ninety (90) samples were used in the study, for dentin permeability test (dye penetration test) and Scanning Electron Microscopic examination (SEM) which were randomly divided into two main groups; group A1, completely removed smear layer, group A2, partially removed smear layer. Each group was subdivided into three subgroups according to the desensitizing agent applied: OliNano SEAL, Curodont D'Senz and the control group that were left untreated. Seventy (70) hypersensitive teeth in ten patients were enrolled for the current study. The subjective assessment of dentin hypersensitivity was done prior to the application of the desensitizing agent (baseline) then immediately, 2 weeks, 4 weeks and 3 months after application of the tested materials. Patients were informed to rate their perception to tactile, air and cold stimuli by using Verbal Rating Score (VRS) and Visual Analogue Scale (VAS).
Primary purpose: TREATMENT

Brief summary: This study was conducted to evaluate and compare the efficacy of Olinanoseal and Curodont D'Senz in treatment of dentin hypersensitivity.

Detailed description: Materials and Methods:- A total of ninety (90) samples were used in the study, for dentin permeability test (dye penetration test) and Scanning Electron Microscopic examination (SEM) which were randomly divided into two main groups; group A1, completely removed smear layer, group A2, partially removed smear layer. Each group was subdivided into three subgroups according to the desensitizing agent applied: OliNano SEAL, Curodont D'Senz and the control group that were left untreated. Seventy (70) hypersensitive teeth in ten patients were enrolled for the current study. The subjective assessment of dentin hypersensitivity was done prior to the application of the desensitizing agent (baseline) then immediately, 2 weeks, 4 weeks and 3 months after application of the tested materials. Patients were informed to rate their perception to tactile, air and cold stimuli by using Verbal Rating Score (VRS) and Visual Analogue Scale (VAS).

Eligibility criteria: Inclusion Criteria:

1. Presence of a minimum of four hypersensitive teeth in each patient.
2. Patients with teeth recorded a discomfort score of two or more to tactile, cold and air stimulation.
3. Teeth having hypersensitivity only on the facial aspect.
4. Patients' willingness to participate in the study

Exclusion Criteria:

1. Patients with any medical or dental condition that could impact the study results during its expected length.
2. Patients with a history of drug addictions and use of potent analgesic and/ or anti-inflammatory drugs.
3. Patients who refused to give their consents.
4. Patients with any extensive or unsatisfactory restorations, prosthesis or orthodontic appliances which involve the cervical areas

Primary outcomes:
measure: dentin hypersensitivity
timeFrame: 2 minutes
measure: dentin hypersensitivity
timeFrame: 2 weeks
measure: dentin hypersensitivity
timeFrame: 4 weeks
measure: dentin hypersensitivity
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of dental Medicine for girls, Al-AZhar University
Study officials:
affiliation: lecturer, faculty of dental medicine, Al-Azhar university
name: Asmaa A mosleh, lecturer
role: STUDY_CHAIR
References: