Clinical trial NCT06813092: Effects of Resistance Exercise Compared to Whole-body Electromyostimulation in Young Female Dentists.
Official title: Effects of a Single Bout of High Intensity, High Velocity Resistance Exercise Compared to Whole-body Electromyostimulation on Cardiometabolic Risk Factors and Markers of Bone Formation and -Resorption in Young Female Dentists.
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Osteopenia
Cardiometabolic Conditions
Keywords: biomarkers
bone metabolism
exercise
whole-body electromyostimulation
female dentists
Lead sponsor: University of Erlangen-Nürnberg Medical School
Sponsor class: OTHER
First posted: 2025-02-06
Enrollment: 16
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Randomized two-arm cross-over design
Primary purpose: OTHER

Brief summary: Due to their high workload and unfavorable working position, young female dentists are particularly at risk of cardiometabolic diseases and an early reduction in bone mineral density (BMD). With focus on the latter issue, short bouts of resistance exercise with high strain magnitude and velocity are commonly considered to be a feasible option to prevent bone loss in the early years of young adulthood. In parallel, whole-body electromyostimulation (WB-EMS) a trainings technology able address all main muscle groups simultaneously, however with dedicated exercise intensity might be a time-effective, joint friendly and safe option to maintain BMD in people unable or unmotivated to exercise conventionally. In the present study, we aim to compare the effects of a single session of WB-EMS versus high intensity, high velocity resistance exercise on biomarkers of bone formation (Procollagen type 1 N propeptide, P1NP) and resorption (C-terminal telopeptide of type I collagen, CTX-I). We hypothesize that no clinically relevant different effects on P1NP and CTX-I were determined.


Eligibility criteria: Inclusion Criteria:

* female dental students (\>3rd semester) or licensed dentists
* no competitive sports background for \>2 years
* normal body mass (BMI\>18,5 and \<25 kg/m2)

Exclusion Criteria:

* more than one resistance exercise session per week (last 12 month)
* whole-body electromyostimulation during the last 12 month
* amenorrhea, oligomenorrhea

Primary outcomes:
measure: Changes for C-terminal telopeptide of type I collagen from pre- to 15 min post-exercise
timeFrame: Immediately pre-exercise to 15 min post exercise of a single exercise session
Secondary outcomes:
measure: Changes for Procollagen type 1 N propeptide from pre- to 15 min post-exercise
timeFrame: Immediately pre-exercise to 15 min post exercise of a single exercise session
measure: Changes for resting glucose from pre- to 15 min post-exercise
timeFrame: Immediately pr to 15 min post-exercise of a single exercise session
measure: Changes for hemoglobin A1c from pre- to 15 min post-exercise
timeFrame: Immediately pre- to 15 min post-exercise of a single exercise session
Other outcomes:
Locations:
city: Erlangen
country: Germany
facility: Institute of Radiology
city: Erlangen
country: Germany
facility: Institute of Radiology, University Hospital NErlangen
Study officials:
affiliation: University Hospital Erlangen, Germany
name: Wolfgang Kemmler, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kemmler W, Bebenek M, von Stengel S, Bauer J. Peak-bone-mass development in young adults: effects of study program related levels of occupational and leisure time physical activity and exercise. A prospective 5-year study. Osteoporos Int. 2015 Feb;26(2):653-62. doi: 10.1007/s00198-014-2918-8. Epub 2014 Oct 7.