louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06748768: The Effect of Omega 3 Supplements Comparison With Warm Compression in Patients With Dry Eye Disease
Official title: The Effect of Omega 3 Supplements Comparison With Warm Compression in Patients With Dry Eye Disease
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Dry Eye
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-12-27
Enrollment: 140
Sex: ALL
Minimum age (years): 20
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: to check the he Effect of Omega 3 Supplements Comparison With Warm Compression in Patients With Dry Eye Disease

Brief summary: dry eye disease is a common condition characterized by tear film instability and ocular surface inflammation. Omega 3 fatty acid and hot compression are two common tratement for dry eye diseases

Detailed description: to investigate the cost effective and efficient treatment for dry eye diseases, During regular visit of patient assessment will be carried out to diagnose disease ,ocular findings and cause of visit .

Eligibility criteria: Inclusion Criteria:

* Young adults (20-39) years diagnosed with dry eyes and willingness to participate with no ocular surgery and infection from last 2 weeks Children

Exclusion Criteria:

* People having supplements
* Patients having diet with omega 3 for 1 month
* Patients who has undergone glaucoma treatment
* Already receiving treatment of dry eyes
* Patients with any ocular surgery

Primary outcomes:
measure: OSDI
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Benazir Bhutu Hospital
state: Punjab
Study officials:
References:
Clinical trial NCT01595568: Prevention and Reduction of Alcohol and Drug Problems in a Clinical Psychiatric Youth Population
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Alcohol Abuse
Drug Abuse
Mood Disorder
Anxiety Disorder
Conduct Disorder
Keywords: Adolescents
Dual Diagnosis
Mental Disorders
Substance Use Problems
Prevention
Lead sponsor: St. Justine's Hospital
Sponsor class: OTHER
First posted: 2012-05-10
Enrollment: 60
Sex: ALL
Minimum age (years): 14
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: In adolescents, mental health problems are frequently associated with substance misuse, even considered a risk factor for alcohol abuse and dependence. This dual diagnosis tends to complicate the patient's treatment and prognosis by increasing, among others, substance use problems, reckless behaviours, relationships and school problems and suicidal thoughts. It is therefore critical to invest time and effort into developing an efficient approach to prevent and reduce substance use problems and offer these children a more global and optimal treatment.

A brief personality-targeted intervention was developed with students of Canadian and English high schools based on four personality factors known to be implicated in the vulnerability to adolescent alcohol misuse (Impulsivity, Anxiety Sensitivity, Negative Thinking and Sensation Seeking) (Conrod et al., 2006,2008, O'Leary-Barrett 2010).

By helping the adolescents to develop better adaptive behaviours, this cognitive-behavioural intervention proved to reduce binge drinking, quantity and frequency of use and substance use problems (Conrod et al., 2006,2011).

The purpose of this study is to assess the impact of this intervention if combined to a regular treatment in a youth psychiatric population.

60 patients aged 14-17 years of a Child and Adolescent psychiatric department will be screened for personality risk with self-report assessments including the Substance Use Risk Profile Scale. Participants will be randomly assigned to a personality matched cognitive-behavioural intervention or a no-intervention control.

The main outcome measures of this study are alcohol and illicit drug outcomes. Secondary measures include mental health symptoms.


Eligibility criteria: Inclusion Criteria:

* Motive for psychiatric consultation
* Able to provide consent from parent/guardian for participation in the study

Primary outcomes:
measure: Change in Binge drinking frequency
timeFrame: Baseline - 4months
measure: Change in Drinking frequency
timeFrame: Baseline - 4 months
measure: Change in Drinking quantity
timeFrame: Baseline - 4 months
measure: Change in Drinking problems
timeFrame: Baseline - 4 months
Secondary outcomes:
measure: Change in Emotional and behavioural problems
timeFrame: Baseline - 4 months
Other outcomes:
Locations:
city: Montréal
country: Canada
facility: CHU Ste-Justine
state: Quebec
Study officials:
References:
Clinical trial NCT01033968: Pain Perception at Laser Treatment
Official title: Pain Perception at Laser Treatment of Peripheral Retinal Degenerations With Green and Infrared Wavelengths
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Laser Therapy, Low-Level
Keywords: lasers
pain measurement
photocoagulation
retina
Lead sponsor: University of Campinas, Brazil
Sponsor class: OTHER
First posted: 2009-12-17
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the pain perception at laser treatment of peripheral retinal degenerations with green and infrared wavelengths.

Detailed description: Purpose: To compare the pain perception at laser treatment of peripheral retinal degenerations with green and infrared wavelengths.

Methods: Thirty patients (60 eyes) were enrolled in the study. Each patient had one eye treated with infrared laser (diode, 810nm) and the other eye treated with green laser (frequency-doubled solid state laser, diode-pumped, with 532-nm). The laser treatment was performed following a standardized protocol. Immediately after photocoagulation, the patient was asked to grading pain perception according an 11-point (i.e. 0-10) numerical rating scale (NRS) 2,3, accompanied by the instructions "Please rate your pain by indicating the number that best describes it". This NRS is represented as a straight line (10 cm in length). The numbers between 0 and 10 are spaced at regular intervals along the line, at either end of the line are two poles that are defined as the extreme limits of the response to be measure, with '0' meaning 'No pain' and '10' meaning 'Pain as bad as you can imagine'.

Eligibility criteria: Inclusion Criteria:

* horseshoe tears and dialyses, besides operculated holes and lattice degeneration in symptomatic patients (photopsias) or with history of retinal disease

Exclusion Criteria:

* severe liver disease, pregnancy, patients on regular analgesics, previous laser photocoagulation, and age less than 18 years old.

Primary outcomes:
measure: Although the treatment of peripheral retinal degenerations with infrared laser to be well tolerated by the majority of the patients, it is more painful than with green wavelength.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Lira RP, Nascimento MA, Arieta CE, de Carvalho KM, Silva VB. Pain perception at laser treatment of peripheral retinal degenerations with green and infrared wavelengths. Am J Ophthalmol. 2010 Nov;150(5):726-730.e1. doi: 10.1016/j.ajo.2010.05.027. Epub 2010 Aug 5.
Clinical trial NCT02558868: Second-Line Oxaliplatin and Irinotecan Versus Irinotecan Alone for Gemcitabine and S-1 Refractory Pancreatic Cancer
Official title: Second-Line Oxaliplatin and Irinotecan Versus Irinotecan Alone for Advanced Pancreatic Cancer Patients Progressed After First-line Gemcitabine and S-1: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Pancreatic Neoplasms
Lead sponsor: Zhejiang University
Sponsor class: OTHER
First posted: 2015-09-24
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is a randomized, open-label, controlled study that will compare the efficacy of oxaliplatin in combination with irinotecan to irinotecan alone as second-line treatment for patients with gemcitabine and S-1 refractory pancreatic cancer.


Eligibility criteria: Inclusion Criteria:

* Patients with histologically confirmed advanced pancreatic cancer who had experienced progression during first-line gemcitabine and S-1 were eligible for enrollment on this open-label, randomized study.
* Additional inclusion criteria were age 18 years or older
* Measurable reference cancer site(s) confirmed with computed tomography (CT) or magnetic resonance imaging (MRI)
* Karnofsky performance status (KPS) of at least 70%
* -Adequate renal function, adequate hepatic function, adequate bone marrow function

Exclusion Criteria:

* The presence of any severe concomitant disease that could interrupt the planned treatment; intractable pain
* Hypersensitivity to study drugs
* Serious cardiovascular disease (eg, unstable coronary artery disease or myocardial infarction within 4 weeks of study start)
* National Cancer Institute CommonToxicity Criteria grade 3 or 4 sensory or motor neuropathy
* Prior or concurrent malignancy (other than pancreatic cancer)
* Female, pregnancy or breastfeeding.

Primary outcomes:
measure: Overall Survival
timeFrame: 1 years
Secondary outcomes:
measure: Progression Free Survival
timeFrame: 1 years
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: First affiliated hospital, Zhejiang University
state: Zhejiang
Study officials:
affiliation: First Affiliated Hospital,Zhejiang University
name: Weijia Fang, Doctor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Oettle H, Riess H, Stieler JM, Heil G, Schwaner I, Seraphin J, Gorner M, Molle M, Greten TF, Lakner V, Bischoff S, Sinn M, Dorken B, Pelzer U. Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer: outcomes from the CONKO-003 trial. J Clin Oncol. 2014 Aug 10;32(23):2423-9. doi: 10.1200/JCO.2013.53.6995. Epub 2014 Jun 30.
Clinical trial NCT02730468: SEP-SEQ Trial - Determining the Etiology of Sepsis Using an Infectious Disease Diagnostic Sequencing Assay
Official title: SEP-SEQ Trial - Determining the Etiology of Sepsis Using an Infectious Disease Diagnostic Sequencing Assay
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sepsis
Lead sponsor: Karius, Inc.
Sponsor class: INDUSTRY
Collaborators: name: Stanford University
First posted: 2016-04-06
Enrollment: 350
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects will be at least 18 years of age and who present to the Emergency Department with the diagnosis of sepsis

Brief summary: The purpose of this study is to evaluate the performance of the Karius Infectious Diseases Plasma Sequencing Assay in patients who present to the emergency room with sepsis.


Eligibility criteria: Inclusion Criteria:

1. 18 years or older
2. Meet 2 of 4 sepsis criteria

   1. Temperature \> 38C or \< 36C
   2. Heart rate \> 90 bpm
   3. Respiratory rate \>20 or PaCO2 \<32mmHg
   4. WBC \>12000/µL or \< 4000/µL or \> 10% bands

Exclusion Criteria:

1. Inability to understand instructions and comply with study-related procedures
2. Any condition that in the opinion of the treating physician will prevent the subject from completing the study.

Primary outcomes:
measure: Accuracy of sequencing assay in diagnosing etiology of sepsis
timeFrame: 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University Hospital
state: California
Study officials:
affiliation: Stanford University
name: Samuel Yang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05128968: Head and Neck Positions for Endotracheal Intubation Using a Videolaryngoscope
Official title: Impact of Head and Neck Positions on Endotracheal Intubation Using a McGRATH MAC Video Laryngoscope
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Endotracheal Intubation
Lead sponsor: SMG-SNU Boramae Medical Center
Sponsor class: OTHER
First posted: 2021-11-22
Enrollment: 174
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: In this study, the investigators evaluate the effect of head positions (simple extension vs. sniffing position vs. head elevation) on endotracheal intubation using a videolaryngoscope.


Eligibility criteria: Inclusion Criteria:

* Patients scheduled for general anesthesia

Exclusion Criteria:

* Limited neck extension
* Anatomical anomalies or history of surgery in the upper airway
* Weak teeth
* Risk of pulmonary aspiration

Primary outcomes:
measure: Ease of intubation
timeFrame: Procedure (During endotracheal intubation)
Secondary outcomes:
measure: Percentage of glottic opening (POGO) score
timeFrame: Procedure (During endotracheal intubation)
measure: Number of attempts
timeFrame: Procedure (At the end of endotracheal intubation)
measure: Intubation time
timeFrame: Procedure (During endotracheal intubation)
measure: Palatopharyngeal wall injury
timeFrame: Procedure (During endotracheal intubation)
measure: Lifting force for exposure of the glottis
timeFrame: Procedure (During endotracheal intubation)
measure: Laryngeal pressure for exposure of the glottis
timeFrame: Procedure (During endotracheal intubation)
measure: Lifting force for advancing an endotracheal tube into the larynx
timeFrame: Procedure (During endotracheal intubation)
measure: Laryngeal pressure for advancing an endotracheal tube into the larynx.
timeFrame: Procedure (During endotracheal intubation)
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul Metropolitan Government Seoul National University Boramae Medical Center
Study officials:
affiliation: SMG-SNU Boramae Medical Center
name: Jin-Young Hwang, PhD.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02267668: Subsymptom Threshold Exercise Protocol Following Mild TBI
Official title: Subsymptom Threshold Exercise Protocol (STEP) to Recovery Following Mild Traumatic Brain Injury: A Pilot Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Traumatic Brain Injury
Keywords: concussion
sports concussion
exercise therapy
Lead sponsor: University Hospitals Cleveland Medical Center
Sponsor class: OTHER
First posted: 2014-10-17
Enrollment: 16
Sex: ALL
Minimum age (years): 14
Maximum age (years): 22
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study will monitor outcomes of two interventions to develop a best practice in the treatment of mild Traumatic Brain Injury (mTBI).

Detailed description: The proposed pilot randomized controlled clinical trial (RCCT) will provide preliminary data to examine the effect of a novel intervention to promote brain health after mild Traumatic Brain Injury (mTBI). The study will implement a randomized controlled clinical trial of a 6 week exercise intervention (STEP) for participants with persistent mTBI symptoms, comparing STEP to standard of care practice in the controls. We will demonstrate the feasibility and acceptability of the STEP intervention. We hypothesize that STEP will lead to meaningful improvement on objective measures of self-reported mTBI symptoms, formal neuropsychological performance, and postural stability.

Eligibility criteria: Inclusion Criteria:

1. Participants who have sustained a concussion and have not experienced symptom resolution by 4 weeks, as indicated by a Post-Concussive Scale - Revised (PCS-R) score of 20 or higher at 4 weeks post-injury or beyond;
2. Participants are high school and college age (14-22 years old);
3. English speaking. -

Exclusion Criteria:

1. Outside of age range for the study (High school or college age)
2. Have physical injuries or comorbidities that restrict the athlete from engaging in the exercise intervention
3. Not fluent in English -

Primary outcomes:
measure: Concussion symptom resolution
timeFrame: 6 weeks
measure: Neuropsychological testing
timeFrame: 6 weeks
measure: Postural stability
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: University Hospitals Case Medical Center
state: Ohio
Study officials:
affiliation: University Hospitals Cleveland Medical Center
name: Christopher Bailey, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Centers for Disease Control and Prevention. Nonfatal traumatic brain injuries related to sports and recreation activities among persons aged </=19 years--United States, 2001-2009. MMWR Morb Mortal Wkly Rep. 2011 Oct 7;60(39):1337-42.
citation: Gagnon I, Galli C, Friedman D, Grilli L, Iverson GL. Active rehabilitation for children who are slow to recover following sport-related concussion. Brain Inj. 2009 Nov;23(12):956-64. doi: 10.3109/02699050903373477.
Clinical trial NCT01105468: Breath Gas Analysis for the Diagnosis of Breast Cancer
Official title: Leistungsbewertungsprüfung: Atemluftanalyse für Die Diagnose Von Brustkrebs, für Die Überwachung Der Therapie Und für Die Voraussage Des Metastasenrisikos
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Mamma Carcinoma
Keywords: Breath gas analysis
Volatile components in exhaled breath
Lead sponsor: Ionimed Analytik GmbH
Sponsor class: INDUSTRY
Collaborators: name: Medical University Innsbruck
First posted: 2010-04-16
Enrollment: 202
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Primary care clinic

Brief summary: The volatile content of the exhaled breath gas of mamma carcinoma patients will be chemically analyzed by proton-transfer-reaction time of flight mass spectrometry.

The goal of the study is to determine typical breath gas components that allow to distinguish patients with mamma carcinoma from women without carcinoma. Further, the investigators will test whether these breath gas markers can be used as tumor markers, which change in a typical manner during the progress of the disease. Finally the data will be investigated for the presence of marker components, that identify patients who will develop metastasis.


Eligibility criteria: Inclusion Criteria:

* Mamma carcinoma diagnosed by histology (cases)
* Mamma carcinoma excluded by radiology (controls)
* At the time of diagnosis before surgery
* At the beginning and during chemotherapy;

Exclusion Criteria:

* No informed consent form singed

Primary outcomes:
measure: Breath gas markers
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Innsbruck
country: Austria
facility: Department of Gynecology and Obstetrics, Medical University Innsbruck
state: Tirol
Study officials:
References:
Clinical trial NCT00069368: ORWH:SCOR on Sex and Gender Factors Affecting Women's Incontinence
Official title: ORWH:SCOR on Sex and Gender Factors Affecting Women's Incontinence
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Urinary Incontinence
Diabetes
Keywords: Healthy
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Sponsor class: NIH
Collaborators: name: University of California, San Francisco
First posted: 2003-09-26
Enrollment: 2161
Sex: FEMALE
Minimum age (years): 44
Maximum age (years): 73
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women aged 40-69 on 1/1/99 who have been Kaiser Permanente members since age 18 and have had half or more of their deliveries at Kaiser Permanente or are nulliparous and have diabetes.

Brief summary: This study consists of two studies with overlapping cohorts. One is a follow up epidemiological study of urinary incontinence, the other is a case control study of lower urinary tract dysfunction in women with diabetes.

Study One:

Subjects for the study will be a retrospective cohort of 2100 middle-aged and older women from a large health maintenance organization who have participated in the Reproductive Risk Factor for Incontinence Study at Kaiser (RRISK). The RRISK I study assembled a retrospective cohort of long-term female Kaiser Permanente members to determine the association between specific childbirth events, hysterectomy, hormone use and urinary incontinence later in life. The study also provides descriptive information on urinary incontinence by type, age, ethnicity, severity and age of onset.

Study Two:

Women with diabetes have a 30-70% increased risk of lower urinary tract dysfunction, including lower urinary tract symptoms, urinary incontinence, and ultimately bladder cystopathy. This sudy investigates the natural history, risk factors, and possible mechanisms of lower urinary tract dysfunction and infection among women with type 2 diabetes as compared to women without diabetes.


Eligibility criteria: Previous participation in the Reproductive Risk Factors for Incontinence Study at Kaiser.

Primary outcomes:
measure: Urinary Outcomes
timeFrame: 1999-2012
Secondary outcomes:
Other outcomes:
Locations:
city: Oakland
country: United States
facility: Kaiser Permanente, Northern California, Division of Research
state: California
Study officials:
affiliation: University of California, San Francisco
name: Jeanette Brown, MD
role: PRINCIPAL_INVESTIGATOR
References: