Clinical trial NCT02803281: Assessment of Patient Frailty Prior to Thoracic Surgery
Official title: Assessment of Patient Frailty Prior to Thoracic Surgery: A Feasibility Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Cancer
Esophageal Cancer
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
First posted: 2016-06-16
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cancer Patients - Lung or Esophageal

Brief summary: Determine the feasibility of assessment of measures of frailty and determine if these measures provide a clinically important contribution of risk assessment in a population of patients undergoing major thoracic surgery for lung or esophageal cancer.

Detailed description: Both gastro-esophageal and lung cancers are major causes of morbidity and mortality worldwide. In Canada the incidence for Esophageal Adenocarcinoma has doubled in the last two decades, while lung cancer is the leading cause of cancer death. Surgery is a treatment option for these patients; however, esophagectomy in particular, is associated with significant morbidity, mortality and adverse effect on quality of life. Despite satisfactory standard preoperative testing to evaluate risk for surgery, some patients experience morbidity and never recover fully from surgery. Frailty assessment may offer a more sensitive measure of a patient's physiologic reserve, which may allow identification of patients who are poor candidates for surgery. There is a lack of consensus of how best to assess frailty prior to surgery. This study aims to analyze frailty assessment as a tool for patient selection for surgery.

Eligibility criteria: Inclusion Criteria:

* Patients with Esophageal or Lung Cancer who will undergo resectional surgery.

Exclusion Criteria:

* Patients undergoing diagnostic or staging procedures or pulmonary wedge excisions will be excluded.
* Patients unable to give informed consent

Primary outcomes:
measure: Feasibility Assessment
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: University Health Network (Toronto General Hospital)
state: Ontario
city: Toronto
country: Canada
facility: University Health Network: Toronto General Hospital
state: Ontario
city: Toronto
country: Canada
facility: University Health Network
state: Ontario
Study officials:
affiliation: University Health Network, Toronto
name: Gail E Darling, MD
role: PRINCIPAL_INVESTIGATOR
References:
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