Clinical trial NCT03295838: Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder
Official title: Symptom, Alexithymia and Self-image Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder: a Naturalistic Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Borderline Personality Disorder
Keywords: Borderline personality disorder
Psychotherapy
Treatment outcome
Pragmatic clinical trials as topic
Mentalization-based treatment
Alexithymia
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
First posted: 2017-09-28
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Patients were selected using a research protocol with defined criteria, all patients that were intended to treat in the Mentalization-based Treatment program were followed over 18 months and assessed for primary and secondary outcomes.
Primary purpose: TREATMENT

Brief summary: The effects of a psychological treatment, Mentalization-Based Treatment, was studied using a research protocol with patients with mood swings and impulsive behavior (borderline personality disorder).

Detailed description: Background: Mentalization-based treatment (MBT) in borderline personality disorder (BPD) has a growing evidence base, but there is a lack of effectiveness and moderator studies. The present study examined the effectiveness of MBT in a naturalistic setting and explored psychiatric and psychological moderators of outcome. Method: Borderline and general psychiatric symptoms, suicidality, self-harm, alexithymia and self-image were measured in a group of BPD patients (n=75) receiving MBT; assessments were made at baseline, and subsequently after 6, 12 and 18 months (when treatment ended). Borderline symptoms were the primary outcome variable.

Eligibility criteria: Inclusion Criteria:

* To be included, BPD diagnosis was confirmed by SCID-II interview and the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) interview, together with a consensus discussion between MBT therapists using DSM-IV and ICD-10 criteria. All patients referred between 2007-02-01 and 2012-05-30 were eligible for inclusion.

Exclusion Criteria:

* Exclusion criteria were: IQ\<85, psychotic disorder other than schizotypal personality disorder, acute/temporary psychosis, previously diagnosed autism-spectrum disorder, bipolar disorder type I and severe eating or substance use disorder.

Primary outcomes:
measure: Borderline Symptoms
timeFrame: 0-18 months
Secondary outcomes:
measure: Suicidality
timeFrame: 0-18 months
measure: General Psychiatric Symptoms
timeFrame: 0-18 months
measure: Self-harm
timeFrame: 0-18 months
measure: Alexithymia
timeFrame: 0-18 months
measure: Self-image
timeFrame: 0-18 months
Other outcomes:
Locations:
Study officials:
affiliation: Karolinska Institutet
name: Viktor Kaldo, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lof J, Clinton D, Kaldo V, Ryden G. Symptom, alexithymia and self-image outcomes of Mentalisation-based treatment for borderline personality disorder: a naturalistic study. BMC Psychiatry. 2018 Jun 11;18(1):185. doi: 10.1186/s12888-018-1699-6.