louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04283214: A Comparison of CPR Outcomes Between Traditional and Endomorphic Manikins With and Without Equipment
Official title: A Comparison of Cardiopulmonary Resuscitation Outcomes Between Traditional and Endomorphic Manikins
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiac Arrest
Lead sponsor: North Dakota State University
Sponsor class: OTHER
First posted: 2020-02-25
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: The study's research design is a randomized experiment. 50 emergency responders (emergency medical responders, emergency medical technicians, advanced emergency medical technicians, and paramedics) will be recruited for this research. All data collection will take place in Lab 14 of the Benson Bunker Fieldhouse or a professional, confidential location of the participant's choosing.

Prior to CPR performance, participants will be given an informed consent form to sign. The form will be explained in detail by the researcher collecting data. After obtaining informed consent, participants will be asked to fill out a demographic questionnaire to collect information such as age, gender, years of emergency responder experience/employment, and years of CPR certification. Demographic information provided by participants will be utilized in data analysis. The demographics form should take approximately five minutes to complete. Participants will be randomly assigned to the four trials they will partake in and instructed via oral script (one for over and one for under football shoulder pads) to perform four-trials total of three-minute single-rescuer CPR on both a traditional CPR manikin and "Fat Old Fred" (bariatric) CPR manikin. CPR must be performed in accordance with the American Heart Association's 2015 CPR Guidelines and participants will use a CPRmeter 2 device to collect data to determine the quality of CPR components (chest compression depth/recoil, compression rate, CPR compression duration, mean depth, mean rate, and total number of compressions). The entire study session should take 25 to 30 minutes to complete.


Eligibility criteria: Inclusion Criteria:

* Emergency responders employed through the ambulance stations located in North Dakota and Minnesota
* Current CPR/first-aid certification
* Active clinician, educator, or administrator.

Exclusion Criteria:

* Cardiovascular conditions inhibiting CPR performance
* Respiratory conditions inhibiting CPR performance
* Musculoskeletal conditions inhibiting CPR performance

Primary outcomes:
measure: Compression depth %
timeFrame: 2 minutes
measure: Compression rate
timeFrame: 2 minutes
measure: Chest recoil
timeFrame: 2 minutes
measure: Compression depth
timeFrame: 2 minutes
measure: Compression rate %
timeFrame: 2 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Fargo
country: United States
facility: North Dakota State University
state: North Dakota
Study officials:
References:
Clinical trial NCT00973414: Fluid Management for Cesarean Section III
Official title: Fluid Management for Cesarean Section Undergoing Combined Spinal Epidural Anesthesia (CSEA)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cesarean Section
Keywords: Combined epidural spinal anesthesia
Fluid therapy
Lead sponsor: Nanjing Medical University
Sponsor class: OTHER
First posted: 2009-09-09
Enrollment: 850
Sex: FEMALE
Minimum age (years): 21
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Regional anesthesia, including epidural, spinal and combined epidural spinal anesthesia (CSEA), is a pivotal part in modern anesthesiology. Previously, the investigators found that epidural and spinal anesthesia during cesarean section possesses different responsiveness to fluid (including crystalloid and colloid) management given prior or posterior to anesthesia. Although CSEA is also widely used as an alternative of single epidural or spinal anesthesia for its combined effect of fast onset of anesthesia of spinal anesthesia and the property of duration of epidural catheterization, the fluid resuscitation during CSEA is still unknown. The investigators hypothesized that fluid management during CSEA would produce different effect on hemodynamics in cesarean section compared with epidural and spinal anesthesia.


Eligibility criteria: Inclusion Criteria:

* 21-40 yr
* First time of delivery
* ASA status I-II
* No premature
* No genetic and infectious diseases
* Chinese

Exclusion Criteria:

* \< 21 yr
* \> 40 yr
* Subjects with cardiac and pulmonary disorders
* Dislocation of placenta
* Pregnant hypertension
* Allergy to local anesthetics
* Unwilling to cooperation
* Need intraoperative administration of vascular active agents
* With significant delivery side effects

Primary outcomes:
measure: Rate of hypotension
timeFrame: Anesthesia begin (0 min) to 120 min after anesthesia
Secondary outcomes:
measure: Recurrence of hypotension after ephedrine or phenylephrine
timeFrame: Anesthesia begin (0 min) to 120 min after anesthesia
measure: Consumption of ephedrine and phenylephrine
timeFrame: Anesthesia begin (0 min) to 120 min after anesthesia
measure: Total volume of colloid or crystalloid
timeFrame: Fifteen minutes before anesthesia to 120 min after anesthesia
measure: One-min and 5-min Apgar scores
timeFrame: The first and fifth minute after cesarean successful delivery
measure: Oxygen saturation during hypotension
timeFrame: Anesthesia begin (0 min) to 120 min after anesthesia
measure: Duration of hypotension
timeFrame: Anesthesia begin (0 min) to 120 min after anesthesia
measure: Low umbilical cord pH (artery < 7.20)
timeFrame: At the time of successful delivery (0 min)
Other outcomes:
Locations:
city: Nanjing
country: China
facility: The Affiliated Nanjing Maternity and Child Health Care Hospital
state: Jiangsu
Study officials:
affiliation: Nanjing Medical University
name: XiaoFeng Shen, MD
role: STUDY_CHAIR
References:
Clinical trial NCT01821014: Satellite-supplementation of Medical Outreach Clinics: a Feasibility Study
Official title: Satellite-supplementation of Medical Outreach Clinics: a Feasibility Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Telemedicine
Primary Health Care
Developing Countries
Diagnosis
Therapeutics
Keywords: Diagnostic concordance
Treatment concordance
patient satisfaction
physician satisfaction
Medical Outreach Clinics
Medical Brigades
Medical Missions
Telemedicine
Videoconference
diagnoses
treatments
Satellite Internet
VSAT
cross cultural telemedicine
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2013-03-29
Enrollment: 144
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Much of the basic general medical care and chronic disease management in rural Honduras comes from groups of volunteers setting up temporary clinics run by volunteers. These clinics, also known as brigades, or medical missions, are often criticized for their lack of quality and the lack of follow-up, both of which stem, in part, from understaffing with volunteer physicians. This study is designed to assess if it is feasible, safe, and acceptable to treat patients in short-term mobile medical clinics in rural Honduras using US physicians connected with patients by videoconference.


Eligibility criteria: Inclusion Criteria:

* Able to give informed consent
* Non-emergent medical complaints
* At least 18 yrs in age

Exclusion Criteria:

* Pregnancy
* Mental Disability

Primary outcomes:
measure: Clinical Diagnoses
timeFrame: Same Day as clinic visit (less than 6 hours)
measure: Recommended clinical treatments
timeFrame: Same Day as clinic visit (less than 6 hours)
Secondary outcomes:
measure: Patient opinions of physician interactions
timeFrame: Immediately following physician interactions (less than 6 hours)
measure: Physician opinions of patient interactions
timeFrame: immediately following volunteer activities with the clinic (less than 48 hours)
measure: Volunteer opinions of physician-patient interactions
timeFrame: immediately following experience with the clinic (Less than 48 hours)
Other outcomes:
measure: Cost
timeFrame: One year (from pilot to completion of study)
Locations:
city: Tegucigalpa
country: Honduras
facility: Global Brigades
state: Francisco Morazan
Study officials:
affiliation: Mayo Clinic
name: Bart Demaerschalk, MD/MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01047514: Healthier Living Canada
Official title: Chronic Disease Self-Management Online Workshop for Canada
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Asthma
Chronic Disease
Lead sponsor: Stanford University
Sponsor class: OTHER
Collaborators: name: AHS Cancer Control Alberta
name: National Council on Aging (NCOA)
First posted: 2010-01-13
Enrollment: 297
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study will evaluate the effectiveness of an online Chronic Disease Self-Management Program for participants in Canada living with chronic health conditions. This pilot will look for improvements in health status, health behaviors and health care utilization.

Detailed description: The Healthier Living with Ongoing Health Problems online workshop provides self-management and self care skills training for people with long-term health conditions such as heart disease, lung disease, diabetes, multiple sclerosis, asthma and others. The workshop is delivered via the Internet over a six-week period. This is a pilot project, which means that it is being run for a limited time to test out its format and its usefulness for participants in Canada. A similar programme has been implemented in the USA, UK, and Australia, but it has to be tried now in Canada to see its usefulness for people in this country. .

The Online workshop is aimed at helping you to take better care of yourself and to better manage your health condition. It is hoped that at the end of the workshop you will be able to do the things you want to do and maintain the relationships that are important to you.

With the facilitators and other workshop participants, you will discuss:

* Dealing with fatigue/tiredness
* Dealing with difficult emotions
* Dealing with your physical symptoms
* Solving the problems caused by your condition
* Starting and maintaining an appropriate exercise or activity programme
* Managing medications
* Communicating better with health care professionals
* Communicating better with your friends, family and colleagues

Eligibility criteria: Inclusion Criteria:Adults 18 and over living with any chronic or long term health condition such as heart disease, lung disease, diabetes. Exclusion Criteria:Not meeting the inclusion criteria

Primary outcomes:
measure: health behaviors
timeFrame: 6 month and 1 year
measure: health utilization
timeFrame: 6 month and 1 year
measure: health status
timeFrame: 6 months and 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University School of Medicine
state: California
Study officials:
affiliation: Stanford University
name: Kate R Lorig
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01628614: A Study of Intraocular Pressure (IOP) Reduction in Newly Diagnosed Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Glaucoma, Open-Angle
Ocular Hypertension
Lead sponsor: Allergan
Sponsor class: INDUSTRY
First posted: 2012-06-27
Enrollment: 4812
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with primary open angle glaucoma or ocular hypertension

Brief summary: This is an observational study and will evaluate IOP reduction in newly diagnosed patients with POAG or OHT. All care (including treatment and diagnostic procedures) provided is at the discretion of the participating physicians according to their clinical judgment and the local standard of medical care.


Eligibility criteria: Inclusion Criteria:

* Newly diagnosed with primary open angle glaucoma or ocular hypertension

Exclusion Criteria:

* None

Primary outcomes:
measure: Percentage of Patients With a Reduction in Intraocular Pressure (IOP) ≥ 5mmHg From Baseline
timeFrame: Baseline, 14 Weeks
Secondary outcomes:
measure: Percentage of Patients With an IOP Reduction ≥10% From Baseline
timeFrame: Baseline, 14 Weeks
measure: Percentage of Patients With an IOP Reduction ≥20% From Baseline
timeFrame: Baseline, 14 Weeks
Other outcomes:
Locations:
city: Barcelona
country: Spain
Study officials:
affiliation: Allergan
name: Medical Director
role: STUDY_DIRECTOR
References:
Clinical trial NCT00905814: A Bioequivalence Study Of AG-013736 Tablets In Healthy Volunteers
Official title: A Phase I Bioequivalence Study To Compare The Plasma Pharmacokinetics Of Five 1-mg And One 5-mg AG-013736 Tablets In Healthy Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy Volunteers
Keywords: Bioequivalence
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2009-05-21
Enrollment: 60
Sex: ALL
Minimum age (years): 21
Maximum age (years): 47
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER

Brief summary: The hypothesis of this study is that one 5 mg tablet of axitinib has similar drug concentrations in plasma compared to five 1 mg tablets of axitinib after oral dosing.


Eligibility criteria: Inclusion Criteria:

* Healthy male and/or female subjects between the ages of 21 and 47 years, inclusive (Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement, 12-lead electrocardiogram (ECG) and clinical laboratory tests).
* Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lbs).
* An informed consent document signed and dated by the subject or a legally acceptable representative.

Exclusion Criteria:

* Evidence of significant disease of the blood, kidney, endocrine system, lungs, gastrointestinal, heart, liver, psychiatric, neurologic, or allergic (including drug allergies, but excluding season allergies).
* Active smokers or users of tobacco containing products and other drugs
* Pregnant or nursing females; females of childbearing potential including those with tubal ligation.

Primary outcomes:
measure: To establish bioequivalence of five 1 mg film coated immediate release (FCIR) tablets of AG-013736 to one 5 mg FCIR tablet of AG-013736.
timeFrame: 3 days per period
Secondary outcomes:
measure: To assess the safety and tolerability of single dose AG-013736 when administered as five 1 mg FCIR tablets and one 5 mg FCIR tablet.
timeFrame: 3 days per period
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: Pfizer Investigational Site
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References:
Clinical trial NCT01797614: Intra-abdominal Pressures During the Spontaneous Breathing Trial
Official title: Measuring the Change of Intra-abdominal Pressures of the Intensive Care Unit Patients During the Spontaneous Breathing Trial
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Respiratory Failure
Keywords: intra-abdominal pressure
spontaneous breathing trail
weaning
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2013-02-22
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients with endotracheal intubation and are preparing for weaning assessment

Brief summary: Increased intra-abdominal pressure (IAP) affects pulmonary dynamics. However, little is studied whether pulmonary dynamics affects IAP. We hypothesize that the change of IAP can also reflect the change of pulmonary dynamics. In this study, we choose patients who received spontaneous breathing trial to answer the hypothesis.

Detailed description: During the weaning process, we tapered down the respiratory support from mechanical ventilation and recruited respiratory muscles to work. Previous study showed that transdiaphragmatic pressure was increasing while pressure support was reducing. However, the transdiaphragmatic pressure required invasive procedure to measure and not used frequently in weaning. IAP reflects the pleural pressure. If the PEEP is not changed, change of IAP is largely due to change of transpulmonary pressure.

Study Aim:

1. To evaluate the patterns of change of IAP during SBT
2. To predict success of SBT by the change of IAP
3. To predict weaning outcome by the change of IAP

Eligibility criteria: Inclusion Criteria:

* Adult patients with endotracheal intubation in the intensive care unit
* The clinical condition is considered to prepare for weaning assessment

Exclusion Criteria:

* tracheostomy
* severe heart failure, heart disease or arrhythmia
* upper airway obstruction related respiratory failure
* poor cooperation due to agitation
* no foley catheter in place or had been removed
* baseline IAP above 20 mmHg

Primary outcomes:
measure: To evaluate the patterns of change of IAP during SBT
timeFrame: 30min, 60min, 120min
Secondary outcomes:
measure: To predict success of SBT by the change of IAP
timeFrame: 0 min, 30 min, 120 min
measure: To predict weaning success by the change of IAP
timeFrame: 0 min, 30 min, 120 min
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Nin-Chieh Hsu
Study officials:
affiliation: National Taiwan University Hospital
name: Nin-Chieh Hsu, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00461214: General Surgery Training Outcomes Project
Official title: General Surgery Training Outcomes Project: Evaluating the Impact of the Curriculum on General Surgery Resident Training and Evaluation
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Healthy
Keywords: laparoscopy
surgery
technical skills
outcomes
resident training
Lead sponsor: Columbia University
Sponsor class: OTHER
First posted: 2007-04-17
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Surgery interns and PGY2-5's

Brief summary: The purpose of the General Surgery Training Outcomes Project: Evaluating the Impact of the Curriculum on General Surgery Resident Training and Evaluation is to analyze data collected as a normal course of the general surgery curriculum. The information collected is data readily available and routinely collected on all participants in the general surgery curriculum at NewYork Presbyterian Hospital/Columbia Campus. This information may lead to improvement in the general surgery curriculum.


Eligibility criteria: Inclusion Criteria:

* All general surgery interns and PGY2-5's at NewYork Hospital/Columbia

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Columbia University College of Physicians and Surgeons
state: New York
Study officials:
affiliation: Columbia University
name: Dennis L Fowler, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06164314: Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors
Official title: Effect of Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors: a Randomized Placebo-controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Postoperative Delirium
Lead sponsor: Beijing Tiantan Hospital
Sponsor class: OTHER
First posted: 2023-12-11
Enrollment: 366
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Neurosurgery is a risk factor for delirium. Dexmedetomidine might reduce delirium by reducing neuroinflammation, improving postoperative analgesia and sleep quality. The the primary hypothesis is that perioperative administration of dexmedetomidine can reduce the incidence of postoperative delirium

Detailed description: The investigators will be required to attend the professional training before recruitment and strictly adhere to the study protocol. All the raw data will be recorded in the case report forms. Data will be entered doubly performed by two investigators and monitored securely in an electronic database with password protection at the medical center. The data base will be locked after all data have been cleaned. All the original fles will be maintained in storage for 5 years after completion of the study.

Eligibility criteria: Inclusion Criteria:

* Patients with temporal glioma scheduled for a elective craniotomy
* Age ≥18 years
* Obtain written informed consent.

Exclusion Criteria:

* Patients with severe preoperative cognitive impairment
* History of traumatic brain injury or previous neurosurgery
* History of psychotropic medications
* Allergy to dexmedetomidine
* Pregnant or lactating women
* History of obstructive sleep apnoea syndrome
* Severe bradycardia(heart rate \<40 beats/min), sick sinus syndrome or second-to-third degree atrioventricular block
* Severe hepatic dysfunction
* Severe renal dysfunction

Primary outcomes:
measure: the incidence of delirium postoperatively
timeFrame: the postoperative 5 days
Secondary outcomes:
measure: the severity of postoperative delirium
timeFrame: the postoperative 5 days
measure: the intensity of pain
timeFrame: the postoperative 5 days
measure: the quality of sleep
timeFrame: the postoperative 5 days
measure: safety outcomes
timeFrame: from the start of medicine infusion to 48 hours postoperatively
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Tiantan Hospital
Study officials:
affiliation: Beijing Tiantan Hospital
name: Yuming Peng
role: PRINCIPAL_INVESTIGATOR
References: