Clinical trial NCT02385682: CardiOvascular Risk and idEntificAtion of Potential High-risk Population in Acute Myocardial Infarction
Official title: CardiOvascular Risk and idEntificAtion of Potential High-risk Population in Korean Patients With Acute Myocardial Infarction Registry (COREA-AMI)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Long-term Major Cardiovascular Events
Myocardial Infarction
Percutaneous Coronary Intervention
Lead sponsor: Seoul St. Mary's Hospital
Sponsor class: OTHER
Collaborators: name: The Catholic University of Korea
name: Chonnam National University
First posted: 2015-03-11
Enrollment: 4748
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Acute myocardial infarction who were treated with percutaneous coronary intervention

Brief summary: The purpose of this registry is to evaluate long-term clinical events in patients with acute myocardial infarction who were treated with percutaneous coronary intervention.

Although numerous articles have been published by using nationwide Korean myocardial infarction registries, such as the Korea Acute Myocardial Infarction Registry (KAMIR), limitation of previous registries is that these have little data beyond the first year of MI. Therefore, current registry was designed to assess long-term clinical events in patients with acute myocardial infarction.

Because most of myocardial infarction patients were treated by revascularization in real world of Korea, this registry limits the inclusion criteria to patients who were treated with percutaneous coronary intervention to reduce the bias.

Detailed description: Cardiovascular center with high-volume percutaneous coronary intervention of following hospitals were participated.

* Seoul St. Mary's Hospital, Seoul, South Korea
* Yeoido St. Mary's Hospital, Seoul, South Korea
* Uijongbu St. Mary's Hospital, Gyeonggi-do, South Korea
* St. Paul Hospital, Seoul, South Korea
* Bucheon St. Mary's Hospital, Gyeonggi-do, South Korea
* Incheon St. Mary's Hospital, Incheon, South Korea
* St. Vincent Hospital, Gyeonggi-do, South Korea
* Deajon St. Mary's Hospital, Daejeon, South Korea
* Cheonnam University Hospital, Gwangju, South Korea

  8 hospitals of the Catholic University of Korea already have web-based coronary intervention registry (NCT01239914). And Cheonnam University Hospital is one of leading hospitals to design and manage the web-based previous Korean nationwide myocardial infarction registry, such as such as the Korea Acute Myocardial Infarction Registry (KAMIR) (http://www.kamir.or.kr/).

All consecutive acute myocardial infarction patients had been enrolled in each registries prospectively.

Using these previous data, current registry update new clinical and angiographic variables and assess long-term clinical follow-up data retrospectively.

Eligibility criteria: Inclusion Criteria:

* Acute myocardial infarction who were treated with percutaneous coronary intervention

Exclusion Criteria:

* Acute myocardial infarction who were managed by conservative strategy
* Acute myocardial infarction who were not treated with percutaneous coronary intervention

Primary outcomes:
measure: Major adverse cardiac and cerebrovascular events
timeFrame: 5 years
Secondary outcomes:
measure: All-cause death
timeFrame: 5 years
measure: Cardiac death
timeFrame: 5 years
measure: Nonfatal myocardial infarction
timeFrame: 5 years
measure: Nonfatal stroke
timeFrame: 5 years
measure: Target lesion revascularization
timeFrame: 5 years
measure: Target vessel revascularization
timeFrame: 5 years
measure: Non-target vessel revascularization
timeFrame: 5 years
measure: Definite/Probable stent thrombosis
timeFrame: 5 years
measure: Hospitalization for heart failure
timeFrame: 5 years
measure: Bleeding defined as the Bleeding Academic Research Consortium (BARC) definitions type 2, 3, and 5
timeFrame: 5 years
measure: Bleeding defined as the thrombolysis In Myocardial Infarction (TIMI) major/minor
timeFrame: 5 years
Other outcomes:
Locations:
Study officials:
affiliation: Seoul St. Mary's Hospital
name: Ki-Bae Seung, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Chonnam National University Hospital
name: Myung Ho Jeong, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ahn Y, Lee D, Choo EH, Choi IJ, Lim S, Lee KY, Hwang BH, Park MW, Lee JM, Park CS, Kim HY, Yoo KD, Jeon DS, Chung WS, Kim MC, Jeong MH, Ahn Y, Chang K. Association Between Bleeding and New Cancer Detection and the Prognosis in Patients With Myocardial Infarction. J Am Heart Assoc. 2022 Nov 15;11(22):e026588. doi: 10.1161/JAHA.122.026588. Epub 2022 Nov 8.
citation: Lim S, Choo EH, Choi IJ, Ihm SH, Kim HY, Ahn Y, Chang K, Jeong MH, Seung KB. Angiotensin Receptor Blockers as an Alternative to Angiotensin-Converting Enzyme Inhibitors in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention. J Korean Med Sci. 2019 Nov 25;34(45):e289. doi: 10.3346/jkms.2019.34.e289.
citation: Kim MC, Ahn Y, Cho JY, Lee KH, Sim DS, Yoon NS, Yoon HJ, Kim KH, Hong YJ, Park HW, Kim JH, Jeong MH, Cho JG, Park JC, Chang K, Seung KB. Benefit of Early Statin Initiation within 48 Hours after Admission in Statin-Naive Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention. Korean Circ J. 2019 May;49(5):419-433. doi: 10.4070/kcj.2018.0341. Epub 2019 Feb 12.