Clinical trial NCT05108181: Muscle Typology and Strength Training Adaptations
Official title: Influence of Muscle Typology and Training Frequency on Chronic Strength Training Adaptations
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Fiber Type
Exercise
Training Frequency
Keywords: Strength training
Muscle typology
Lead sponsor: University Ghent
Sponsor class: OTHER
First posted: 2021-11-04
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: All participants will receive the same training intervention but the subjects are divided into two groups based on an inherent physiological characteristic: the muscle typology. A slow typology group (people with a lot of slow muscle fibers) and a fast typology group (people with a lot of fast muscle fibers). Each participant will train their legs and arms unilateral and one arm and one leg will train two times per week, while the other arm and leg will train three times per week for 9 weeks. The assignment of the limbs to the 3x/week condition and the 2x/week condition is randomized. The training outcomes of the two groups will be compared as well as the within subject differences between training two times per week or training 3 times per week.
Primary purpose: BASIC_SCIENCE

Brief summary: The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers.

Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).


Eligibility criteria: Inclusion Criteria:

* Fast or slow muscle typology
* 18 - 45 years old
* no strength training experience

Exclusion Criteria:

* Vegan/vegeterian diet
* Supplement intake
* chronic diseases
* Hypertension,
* Smoking
* Medication use
* Coagulation disorder, infectious diseases

Primary outcomes:
measure: Change from baseline muscle volume at 9 weeks
timeFrame: Pre and post the 9 weeks training period
measure: Change from baseline dynamic muscle strength at 3 weeks
timeFrame: Pre, mid and post 9 weeks training period
measure: Change from baseline dynamic muscle strength at 6 weeks
timeFrame: Pre, mid and post 9 weeks training period
measure: Change from baseline dynamic muscle strength at 9 weeks
timeFrame: Pre, mid and post 9 weeks training period
measure: Change from baseline isometric muscle strength at 9 weeks
timeFrame: Pre and post 9 weeks training period
measure: Change in muscle fiber type specific hypertrophy at 9 weeks
timeFrame: Pre and post 9 weeks training period
Secondary outcomes:
measure: Change of baseline antropometry at 9 weeks
timeFrame: Pre and post 9 weeks training period
measure: Change of baseline skeletal muscle protein content at 9 weeks
timeFrame: Pre and post 9 weeks training period
measure: Change of baseline histochemistry at 9 weeks
timeFrame: Pre and post 9 weeks training period
measure: Change from basline fatigue feeling over 9 weeks training period
timeFrame: Assessed every training during the 9 weeks training period
measure: Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks
timeFrame: Pre and post 9 weeks training period
Other outcomes:
Locations:
city: Gent
country: Belgium
facility: Department of Movement and Sports Sciences, Ghent University
state: Oost-Vlaanderen
Study officials:
affiliation: University Ghent
name: Wim Derave
role: PRINCIPAL_INVESTIGATOR
References: