Clinical trial NCT04361110: Radiological Findings in Primary Intestinal Ischaemia
Official title: Preoperative Findings on Non-specific CT in Patients With Primary Acute Intestinal Ischaemia; a Case-control Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Intestinal Ischemia
Keywords: Diagnoses Disease
Lead sponsor: Aalborg University Hospital
Sponsor class: OTHER
First posted: 2020-04-24
Enrollment: 130
Sex: ALL
Maximum age (years): 120
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All operated patients at Department of Gastrointestinal surgery, Aalborg University Hospital, Denmark.

Brief summary: To investigate which findings on a non-specific CT scan that predict acute primary intestinal ischaemia.

Detailed description: 48 patients with primary intestinal ischemia admitted in 4 consecutive years (2006-2009) in Department of Gastrointestinal Surgery, Aalborg University Hospital. Control group consists of 82 patients operated in the same department and in the same time range.

Abdominal CT scans are described with respect to intestinal diameter, changes in intestinal wall, extra intestinal changes and vessel pathology.

Eligibility criteria: Inclusion Criteria:

* Primary acute intestinal ischaemia in an abdominal operation.
* CT-scan within 48 hours preoperative.

Exclusion Criteria:

* Secondary intestinal ischaemia
* Intestinal ischaemia isolated intestinal mucosa.
* No CT-scan within 48 hours preoperative

Primary outcomes:
measure: Intestinal wall pathology
timeFrame: 48 hours
measure: Gastrointestinal vessel pathology
timeFrame: 48 hours
measure: Intestinal diameter
timeFrame: 48 hours
measure: Extraintestinal pathology
timeFrame: 48 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Menke J. Diagnostic accuracy of multidetector CT in acute mesenteric ischemia: systematic review and meta-analysis. Radiology. 2010 Jul;256(1):93-101. doi: 10.1148/radiol.10091938.
citation: Karkkainen JM, Acosta S. Acute mesenteric ischemia (part I) - Incidence, etiologies, and how to improve early diagnosis. Best Pract Res Clin Gastroenterol. 2017 Feb;31(1):15-25. doi: 10.1016/j.bpg.2016.10.018. Epub 2017 Jan 4.
citation: Tilsed JV, Casamassima A, Kurihara H, Mariani D, Martinez I, Pereira J, Ponchietti L, Shamiyeh A, Al-Ayoubi F, Barco LA, Ceolin M, D'Almeida AJ, Hilario S, Olavarria AL, Ozmen MM, Pinheiro LF, Poeze M, Triantos G, Fuentes FT, Sierra SU, Soreide K, Yanar H. ESTES guidelines: acute mesenteric ischaemia. Eur J Trauma Emerg Surg. 2016 Apr;42(2):253-70. doi: 10.1007/s00068-016-0634-0.
citation: Cudnik MT, Darbha S, Jones J, Macedo J, Stockton SW, Hiestand BC. The diagnosis of acute mesenteric ischemia: A systematic review and meta-analysis. Acad Emerg Med. 2013 Nov;20(11):1087-100. doi: 10.1111/acem.12254.
citation: Aschoff AJ, Stuber G, Becker BW, Hoffmann MH, Schmitz BL, Schelzig H, Jaeckle T. Evaluation of acute mesenteric ischemia: accuracy of biphasic mesenteric multi-detector CT angiography. Abdom Imaging. 2009 May-Jun;34(3):345-57. doi: 10.1007/s00261-008-9392-8.
citation: Straarup D, Gotschalck KA, Mikalone R, Thorlacius-Ussing O. Preoperative findings on non-specific CT in patients with primary acute intestinal ischemia: a case-control study. Eur J Trauma Emerg Surg. 2022 Aug;48(4):3025-3032. doi: 10.1007/s00068-021-01741-w. Epub 2021 Jul 3.