Clinical trial NCT05981612: Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents
Official title: Effects of Emotional Reactivity on Decision-Making in Adolescents With Nonsuicidal Self-Injury
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Nonsuicidal Self Injury
Prediction Errors
Lead sponsor: University of Electronic Science and Technology of China
Sponsor class: OTHER
First posted: 2023-08-08
Enrollment: 80
Sex: ALL
Minimum age (years): 15
Maximum age (years): 18
Standard ages: CHILD
ADULT
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Treatment-seeking NSSI individuals will be recruited from local hospitals and HC from the community.

Brief summary: Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.


Eligibility criteria: Inclusion Criteria:

* 15-18 years
* right-handed
* normal or corrected normal visual acuity
* meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)

Exclusion Criteria:

* diagnosis of borderline personality disorder, major depressive disorder, other
* psychiatric disorders, etc.
* high suicidal risk
* recent use of medications that can affect neural activity
* have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months
* have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)

Primary outcomes:
measure: Reward prediction errors (PEs)
timeFrame: About 20 minutes
measure: Valence prediction errors (PEs)
timeFrame: About 20 minutes
measure: Arousal prediction errors (PEs)
timeFrame: About 20 minutes
measure: The prediction of PEs of punishment decisions
timeFrame: About 20 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Chengdu
country: China
facility: Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China
state: Sichuan
Study officials:
References: