Clinical trial NCT06296108: Risk Factors for Acute Kidney Injury in Patients Undergoing Arthroplasty
Official title: Risk Factors for Acute Kidney Injury in Patients Undergoing Total Joint Arthroplasty
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Acute Kidney Injury
Arthroplasty
Keywords: arthroplasty
acute kidney injury
Lead sponsor: Ankara University
Sponsor class: OTHER
First posted: 2024-03-06
Enrollment: 911
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aged above 18 years old undergoing arthroplasty surgery

Brief summary: The authors aimed to determine the risk factors associated with postoperative acute kidney injury in patients undergoing total joint arthroplasty.

Detailed description: Aim: The primary aim of the current study is to determine the risk factors associated with postoperative acute kidney injury in patients undergoing total joint arthroplasty. Considering that this patient group is mostly composed of advanced age and comorbid patients, the secondary aim of the study is to identify risky patients with predictable risk factors and to chart a way to make preoperative optimizations of the patients before developing postoperative complications.

Materials and Methods: Patients who underwent joint arthroplasty between 2015 and 2020 in Ankara University Faculty of Medicine, Department of Orthopedics and Traumatology were included. Within the scope of the study, patients' gender, age, weight, height, body mass index values, smoking, American Society of Anesthesiologist (ASA) score, Charlson-Comorbidity Index score (CCI), type of operation, duration of surgery, presence of intraoperative hypotension, anesthesia method , diabetes, hypertension, coronary artery disease, presence of congestive heart failure, presence of preoperative anemia, preoperative uric acid and albumin level, use of nephrotoxic agents in the perioperative period, basal creatinine and glomerular filtration rate (GFR) values, platelet suspension in the perioperative period, erythrocyte suspension, Amounts of fresh frozen plasma transfusions, postoperative creatinine at 24 hours - 48 hours - discharge, GFR values and Kidney Disesae Improving Global Outcomes (KDIGO) scores, length of hospital stay and length of stay in the intensive care unit were evaluated.

Eligibility criteria: Inclusion Criteria:

* Patients aged above 18 years old undergoing arthroplasty surgery

Exclusion Criteria:

* Known acute renal failure or chronic renal failure
* Patients aged below 18 years old
* Patients refusing to participate to the study

Primary outcomes:
measure: Acute kidney injury in patients undergoing arthroplasty surgery
timeFrame: Retrospective between 2015-2020
Secondary outcomes:
measure: Risk factors causing acute kidney injury in patients undergoing arthroplasty surgery
timeFrame: Retrospective between 2015-2020
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara University Medical School Anesthesiology and ICU Department
Study officials:
affiliation: Ankara University Medical School, Department of Anesthesiology and ICU
name: Sanem Çakar Turhan, Assoc. Prof.
role: STUDY_CHAIR
affiliation: Ankara University Medical School, Department of Anesthesiology and ICU
name: Hazal Nur Tezel Kılıc, Specialist
role: PRINCIPAL_INVESTIGATOR
affiliation: Ankara University Medical School, Department of Anesthesiology and ICU
name: Suheyla Karadag Erkoc, Assoc. Prof.
role: PRINCIPAL_INVESTIGATOR
affiliation: Ankara University Medical School, Department of Orthopedics and Traumatology Surgery
name: Hakan Kocaoglu, Assoc. Prof.
role: PRINCIPAL_INVESTIGATOR
References: