Clinical trial NCT06419244: Myosteatosis in Oeso-gastric Cancer: Clinical Impacts
Official title: Myosteatosis in Oeso-gastric Cancer: Clinical Impacts
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Esophageal Cancer
Gastric Cancer
Myopenia
Adipose Tissue Tumor
Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2024-05-17
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of this project is to study the presence of cancer-associated adipocytes in oesogastric cancers and their possible links with myosteatosis. This research project has a retrospective component, the aim of which is to analyse the body component based on imaging in patients with oesogastric neoplasia in order to determine the incidence of myosteatosis and to study the relationship with oncological and prognostic data. The second part of the project is prospective and will collect biological material (skeletal muscle, adipose tissue, tumour, blood) for histological, molecular and genomic analyses and will analyse muscle function in patients with oesogastric cancer. It will address the role of adipocytes in the tumour microenvironment of oesogastric cancer, focusing on their interactions with the observed muscle myosteatosis and prognosis. In the future, it will help to identify signalling pathways, targets and patients who could benefit from appropriate treatment.

Detailed description: Oesophageal and gastric cancer pose a significant challenge to caregivers, both in terms of the complexity of its presentation and its treatment. At diagnosis, patients often present with malnutrition associated with sarcopenia, which has a significant impact on morbidity and mortality. Although loss of muscle mass has received much attention in cancer, muscle quality, particularly the accumulation of fat in muscle named "myosteatosis", may be considered as a better predictor of a patient's physical condition and ability to recover from cancer treatments. Studying the tumor microenvironment is essential to understanding the mechanisms underlying disease progression. Cancer-associated adipocytes (CAA), a major component of this tumor microenvironment, provide an interface for dialogue with the tumor through the secretion of pro-inflammatory cytokines, metalloproteases and the release of free fatty acids. They have been described as capable of stimulating tumor progression, particularly in breast cancer. However, their presence in oesogastric cancer and possible links with myosteatosis have not been described.

Eligibility criteria: Inclusion Criteria:

* Patients with cancer of the oesophagus, oeso-gastric junction or stomach
* Treatment and estimated survival of more than 3 months
* Signed informed consent
* \> 18 years of age

Exclusion Criteria:

* Neuromuscular or orthopedic pathology
* Cognitive disorders
* Psychiatric disorders
* Inability to communicate in French or English

Primary outcomes:
measure: Myosteatosis
timeFrame: Through study completion, an average of 2 years
Secondary outcomes:
measure: Physical functional status 1
timeFrame: Through study completion, an average of 2 years
measure: Physical functional status 2
timeFrame: Through study completion, an average of 2 years
measure: Physical functional status 3
timeFrame: Through study completion, an average of 2 years
measure: Cancer-associated adipocytes
timeFrame: Through study completion, an average of 2 years
Other outcomes:
Locations:
city: Bruxelles
country: Belgium
facility: Cliniques universitaires Saint-Luc
Study officials:
affiliation: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
name: Yannick Deswysen, MD
role: PRINCIPAL_INVESTIGATOR
References: