Clinical trial NCT03703973: Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery
Official title: Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Postoperative Cognitive Dysfunction
Keywords: Postoperative Cognitive Dysfunction
Leukocyte Telomere Length
Lead sponsor: Xuzhou Medical University
Sponsor class: OTHER
First posted: 2018-10-12
Enrollment: 1000
Sex: ALL
Minimum age (years): 60
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: We included 1000 Male and female patients undergoing non-cardiac surgery and 50 healthy volunteers at the affiliated hospital of Xuzhou Medical University.

Brief summary: To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。


Eligibility criteria: Inclusion Criteria:

* Non-cardiac surgery patients;

  * Age is greater than or equal to 65 years old;

    * Han Nationality, mother tongue is chinese;

      ④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;

      ⑤The Geriatric Depression Scale (GDS) grade 1 or 2;

      ⑥The important function without serious heart, brain, liver, kidney, lung and other organs;
      * The ASA class I or II;

        * The people signed informed consent.

Exclusion Criteria:

* The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ②Had severe head and face disease, trauma history or history of surgery;

  * Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease.

Primary outcomes:
measure: the neuropsychological test to measure cognitive function
timeFrame: 1 day before surgery(baseline)
measure: Mini-Mental score examination [MMSE] used for screening of dementia
timeFrame: 1 day before surgery(baseline)
measure: the leukocyte telomere length
timeFrame: on the surgery day
measure: the neuropsychological test to measure cognitive function
timeFrame: within the first 7 days (plus or minus 2 days) after surgery
measure: Mini-Mental score examination [MMSE] used for screening of dementia
timeFrame: within the first 7 days (plus or minus 2 days) after surgery
measure: the neuropsychological test to measure cognitive function
timeFrame: within the first 3 months (plus or minus 1 month) after surgery
measure: Mini-Mental score examination [MMSE] used for screening of dementia
timeFrame: within the first 3 months (plus or minus 1 month) after surgery
measure: the neuropsychological test to measure cognitive function
timeFrame: within the first 1 year (plus or minus 3 months) after surgery
measure: Mini-Mental score examination [MMSE] used for screening of dementia
timeFrame: within the first 1 year (plus or minus 3 months) after surgery
measure: the neuropsychological test to measure cognitive function
timeFrame: within the first 3 years (plus or minus 1 year) after surgery
measure: Mini-Mental score examination [MMSE] used for screening of dementia
timeFrame: within the first 3 years (plus or minus 1 year) after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Xuzhou
country: China
facility: Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University
state: Jiangsu
Study officials:
References: