Clinical trial NCT06825650: Investigation of the Cultural Adaptation, Validity, and Reliability of the Turkish Version of the CAP Questionnaire
Official title: Investigation of the Cultural Adaptation, Validity, and Reliability of the Turkish Version of the Central Aspects of Pain (CAP) Questionnaire
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Osteoarthritis
Back Pain
Fibromyalgia
Keywords: nociplastic pain
central sensitization
back pain
osteoarthritis
fibromyalgia
pain
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2025-02-13
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study population will consist of individuals who come to the university hospital for routine controls.

Brief summary: The "CAP questionnaire," developed by modifying the CAP-Knee questionnaire to assess potential nociplastic pain features in painful musculoskeletal disorders, has been described. The "CAP questionnaire" is used in people with musculoskeletal pain and diagnostic subgroups of osteoarthritis, back pain, and fibromyalgia. There is no Turkish version of the CAP questionnaire. This study aims to investigate the cultural adaptation, validity, and reliability of the Turkish version of the "CAP questionnaire."

Detailed description: Chronic pain is a symptom shared by many musculoskeletal conditions, even when disease management is optimized. Musculoskeletal pathologies are reported to be an essential therapeutic target in pain management. However, these pathologies often do not adequately explain the pain or the reason for its persistence.

Central sensitization is the increased sensitivity of Central Nervous System (CNS) neurons to a standard nociceptive input. Pain that increases in intensity and distribution beyond that explained by musculoskeletal pathology has been termed "nociplastic pain." Measuring these CNS aspects of pain is a prerequisite for understanding their mechanistic basis and predicting future pain and responses to treatment. Chronic pain is associated with CNS dysfunction in several areas, including depression, anxiety, pain catastrophizing, cognitive dysfunction, sleep disturbance, and fatigue. Considering the increasing importance of assessing mood-related pain (nociplastic pain) The "CAP questionnaire," developed by modifying the CAP-Knee questionnaire to assess potential nociplastic pain features in painful musculoskeletal disorders, has been described.

Eligibility criteria: Inclusion Criteria:

* People with musculoskeletal pain and in diagnoses with OA, back pain, or FM
* Above 18 years of age
* Informed consent of the participant

Exclusion Criteria:

* Diagnosis of uncontrolled/other clinically significant diseases (chronic obstructive pulmonary disease, congestive heart failure, endocrine system diseases, neurological, psychological diseases, etc.)
* Pregnant women

Primary outcomes:
measure: Central Aspects of Pain Questionnaire (CAP)
timeFrame: Three months
Secondary outcomes:
measure: BETY-Biopsychosocial Questionnaire
timeFrame: Three months
measure: Hospital Anxiety Depression Scale (HADS)
timeFrame: Three months
measure: Health Assessment Questionnaire (HAQ)
timeFrame: Three months
measure: Pain Catastrophizing Scale (PCS)
timeFrame: Three months
measure: Central Sensitisation Inventory (CSI)
timeFrame: Three months
measure: Short-Form of McGill's Pain Questionnaire
timeFrame: Three months
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University
state: Altındağ
Study officials:
References: