louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03544944: A Prospective, Randomized, Single-blinded (Evaluator), Parallel, Multi-center, Phase 3 Trial in Bowel Preparation for Colonoscopy
Official title: A Prospective, Randomized, Single-blinded (Evaluator), Parallel, Multi-center, Phase 3 Trial in Bowel Preparation for Colonoscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Bowel Preparation
Keywords: bowel preparation
Lead sponsor: Taejoon Pharmaceutical Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2018-06-04
Enrollment: 297
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a prospective randomized study compared with active control arm. The investigators compare the colon cleansing in patients undergoing colonoscopy.


Eligibility criteria: Inclusion Criteria:

* Patients must provide written informed consent.
* Male and female outpatients and inpatients aged: ≥19
* Patients BMI shoule be ≤ 30

Exclusion Criteria:

* Patients with past history within last 12 months or current episode of severe constipation
* Known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
* Known phenylketonuria.
* Clinically relevant findings on physical examination based on the Investigator's judgment.

Primary outcomes:
measure: Ratio of subjects With successful Bowel Cleansing
timeFrame: 1 day of scheduled colonoscopy
Secondary outcomes:
measure: Easch segments ratio of subject with successful Bowel Cleansing
timeFrame: 1 day of scheduled colonoscopy
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Taejoon Pharmaceutical Co., Ltd.
Study officials:
References:
Clinical trial NCT06425744: Impact of Pilates and Myofascial Release on Women's Chronic Low Back Pain
Official title: The Effect of Self-Myofascial Release and Pilates Reformer Exercise on Pain, Muscle Function and Quality of Life in Women With Chronic Low Back Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Low Back Pain
Keywords: low back pain
Pilates
Myofasical Release
Pain
Flexibility
Lead sponsor: Sahmyook University
Sponsor class: OTHER
First posted: 2024-05-22
Enrollment: 32
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to find out if Reformer Pilates and self-myofascial release are effective for pain and muscle function in women with chronic low back pain. Investigators will also look at changes in quality of life. The main questions for the study are

Can Reformer Pilates and self-myofascial release reduce pain in participants? Can Reformer Pilates and self-myofascial release change muscle function in participants? The researchers want to compare the effects of Reformer Pilates and self-myofascial release in women with chronic low back pain.

Participants will be

Group 1 Perform Reformer Pilates and self-myofascial release exercises twice a week for 6 weeks, for a total of 12 sessions.

Group 2 Perform Reformer Pilates exercises twice a week for 6 weeks, for a total of 12 sessions.

Participants will visit the Pilates Centre for an examination before and once after starting the programme.

All groups perform a home exercise training programme for 15 minutes three times a week.


Eligibility criteria: Inclusion Criteria:

* People who have had chronic low back pain for 12 weeks or more
* Have a Korean Oswestry Disability Index (KODI) score of 17% or higher

Exclusion Criteria:

* Patients with low back pain due to trauma, neurological lesions of the lower extremities, herniated disc lesions, hip, pelvic or abdominal surgery
* Patients who have received radiation or injections within the last 3 months,
* Pregnant women or patients who have given birth within the last year

Primary outcomes:
measure: Pain severity
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: Functional disability caused by low back pain
timeFrame: From enrollment to the end of treatment at 6 weeks
Secondary outcomes:
measure: Flexibility of lower back and hamstring
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: Muscular endurance
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: Quality of life questionnaire
timeFrame: From enrollment to the end of treatment at 6 weeks
Other outcomes:
Locations:
city: Goyang-si
country: Korea, Republic of
facility: Pilates Dasom
state: Gyeonggi-do
Study officials:
References:
Clinical trial NCT00437944: Relation Between Polymorphism in Genes Related to Kidney Disease and Renal Manifistations in Fabry Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fabry
Renal Disease
Lead sponsor: Shaare Zedek Medical Center
Sponsor class: OTHER
Collaborators: name: Johannes Gutenberg University Mainz
First posted: 2007-02-21
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: DEFINED_POPULATION
Time perspective: OTHER

Brief summary: The rational of the study is to try to predict which of the patients who suffer from Fabry disease will have End Stage Renal Disease. We hope to find correlation between certain modifier genes, previously related to renal disease, to renal disease in Fabry.


Eligibility criteria: Inclusion Criteria:Fabry disease -

Exclusion Criteria:none

-

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
name: Gheona Altresko
role: STUDY_DIRECTOR
References:
Clinical trial NCT06869044: A Clinical Comparison of Proclear® 1 Day Multifocal and Clariti® 1 Day Multifocal 3 Add
Official title: A Clinical Comparison of Two Soft Multifocal Contact Lenses - Proclear® 1 Day Multifocal and Clariti® 1 Day Multifocal 3 Add
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Myopia
Hyperopia
Presbyopia
Lead sponsor: CooperVision International Limited (CVIL)
Sponsor class: INDUSTRY
Collaborators: name: University of California, Berkeley
First posted: 2025-03-11
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The aim of this study is to compare the overall lens satisfaction between two soft multifocal contact lenses.

Detailed description: The aim of the study is to evaluate the overall lens satisfaction between two soft multifocal contact lenses when compared to each other after 15 minutes of daily wear each.

Eligibility criteria: Inclusion Criteria:

1. They are at least 18 years of age.
2. They understand their rights as a research subject and are willing and able to sign a Statement of Informed Consent.
3. They habitually use soft contact lenses (multifocal soft contact lenses, sphere lenses for monovision, sphere lenses for distance vision correction and spectacles for near vision correction,) and have done so for at least the past three months.
4. They have a minimum reading add of +0.75DS (based on their spectacle refraction)
5. They have spherical equivalent refractive error between +6.00 to -10.00DS at the corneal plane and refractive astigmatism of no greater than -0.75DC in each eye.
6. They are able to achieve distance HCVA of +0.10 logMAR or better in each eye.

Exclusion Criteria:

1. They have an ocular disorder which would normally contra-indicate contact lens wear.
2. They have a systemic disorder which would normally contra-indicate contact lens wear.
3. They are aphakic.
4. They have had corneal refractive surgery.
5. They have any corneal distortion resulting from previous hard or rigid lens wear or have keratoconus.

Primary outcomes:
measure: Overall lens satisfaction
timeFrame: At the end of 15 minutes wear
Secondary outcomes:
Other outcomes:
Locations:
city: Berkeley
country: United States
facility: University of California, Berkeley, CA
state: California
Study officials:
affiliation: UC Berkeley
name: Meng C Lin, OD, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03963544: Patterns of Care and Outcomes of Patients With METAstatic Gastrointestinal Stromal Tumors (METAGIST)
Official title: Patterns of Care and Outcomes of Patients With METAstatic Gastrointestinal Stromal Tumors (GIST) in a Real-life Setting: the METAGIST Observational Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Gastro Intestinal Stromal Tumor
Lead sponsor: Institut Bergonié
Sponsor class: OTHER
Collaborators: name: French Sarcoma Group
First posted: 2019-05-24
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: metastatic Gastrointestinal Stromal Tumor

Brief summary: Gastro intestinal stromal tumors (GIST) are rare mesenchymal tumors of the gastrointestinal tract characterized by somatic mutations in the gene encoding the KIT or the PDGFR alpha protein1. Treatment of localized forms relies on adequate surgery without tumor spillage and systemic treatment with imatinib according to risk of relapse defined by localization, tumor size and mitotic count, as well as mutational status. Advanced and relapsing forms are currently treated with oral tyrosine-kinase inhibitors (TKI) of KIT and PDGFR such as Imatinib, Sunitinib and Regorafenib. Over two decades significant changes in drug discovery have impacted treatment strategies, notably via patient's access to various clinical trials. The use of focal treatments such as surgery or interventional radiology with mini invasive procedure of oligometastasis is also being proposed in some cases.

There is no precise data on patterns of sequential treatments used, especially proportions of patients with metastatic GIST eventually benefiting from access to a clinical trial or a focal treatment strategy in the course of their disease, and their results in terms of survival on a real life national level.

Using the French sarcoma Group national database we aim at describing treatments strategies proposed patients with metastatic GIST in the real life setting.

Objectives include : (i) Description of clinico-biological profiles, patterns of care and modalities of treatment of patients with metastatic GIST in a real-life national setting and (ii) evaluation of impact of each treatment line on patients outcome in terms of time to next treatment (TNT) and survival


Eligibility criteria: Inclusion Criteria:

* patients ≥ 18 years old
* with a diagnosis of metastatic Gastrointestinal Stromal Tumor (metastatic at diagnostic or metastatic relapse)
* From 1990 to 2018

Exclusion Criteria:

-

Primary outcomes:
measure: Time to next treatment (TNT)
timeFrame: 2 years
measure: Overall survival (OS)
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: Institut Bergonié, Comprehensive Cancer Center
Study officials:
affiliation: Institut Bergonié
name: Maud Toulmonde, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01524744: A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Oral Lichen Planus
Keywords: oral lichen planus treatment pimecrolimus
Lead sponsor: Mashhad University of Medical Sciences
Sponsor class: OTHER
First posted: 2012-02-02
Enrollment: 40
Sex: ALL
Minimum age (years): 8
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the effect of topical Pimecrolimus with adcortyl on erosive-atrophic 0ral lichen planus in a randomized clinical trial study.


Eligibility criteria: Inclusion Criteria:

* Biopsy confirmed oral lichen planus in combination with a compatible clinical appearance was used for diagnosis.

Exclusion Criteria:

* Unable to undergo oral biopsy for diagnosis
* Systemic diseases or malignancy
* Pregnancy
* Lesion/lesions with dysplasia/ history of allergic reaction to corticosteroids or immunomodulatory drugs.
* Lesions adjacent to amalgam filling were also excluded from this study.

Primary outcomes:
measure: signs of oral lichen planus
timeFrame: every 2 weeks
Secondary outcomes:
measure: symptoms of oral lichen planus
timeFrame: every 2 weeks
Other outcomes:
Locations:
city: Mashhad
country: Iran, Islamic Republic of
facility: Mashhad University of Medical Science
state: Khorasan Razavi
Study officials:
affiliation: Mashhad University of Medical Science
name: atessa pakfetrat, associate professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04811144: Clinical Application of Er:YAG Dental Laser System
Official title: Clinical Application of Er:YAG Dental Laser System
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Laser Therapy
Keywords: Er:YAG
dentistry
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
First posted: 2021-03-23
Enrollment: 129
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study aim was to evaluate the effectiveness of Er:YAG dental laser treatment modality for cavity, sensitive teeth, abnormal frenum attachment and peri-implantitis.

Detailed description: There are four indications will be included in this plan. They are Cavity, Sensitive Teeth, Abnormal Frenum Attachment and Peri-implantitis. Each indication has different procedures which are listed as below:

Cavity: history records, affected range check, X-ray\&photo, treatment, pain index check, return visit check after two weeks. Sensitive Teeth: history records, sensitive check, X-ray\&photo, treatment, pain index and effectiveness check, return visit check after two weeks. Abnormal Frenum Attachment: history records, abnormal position check, photo, cutting, pain index check, return visit check after three, five and seven days. Peri-implantitis: History records, measure periodontal pocket depth, anaerobes collect, X-ray, photo, CT, treatment, pain index check, return visit check after one week, two weeks, four weeks and three months, six months check the effectiveness and collect anaerobes during every return visit. In the last return visit, X-ray and CT would be included.

Eligibility criteria: Inclusion Criteria:

* Ages: 20 years and above。
* Patients are available for multiple follow-up visits for the duration of the study.
* Having the mental ability to express informed consent.
* Patients clinically diagnosed as having Cavity, Sensitive Teeth, Abnormal Frenum Attachment or Peri-implantitis.

Exclusion Criteria:

* Severe diabetes and chronic diseases are excluded.
* CVA patients or the patients taking anti-rejection medicine and osteoporosis drugs for long-term should be excluded.
* Patient who suffer from photodermatosis and photosensitive patients (photoallergic).
* The health condition is not well after health education and physical therapy are excluded.
* Surgery on patients with serious diseases of the hemopoietic system (such as haemophilia and leukaemia).
* Malignant tumours, obligate precancerous tumours, hemangiomas.
* Coronary heart disease and chronic obstructive pulmonary diseases are excluded.
* Pregnant woman.

Primary outcomes:
measure: pain index
timeFrame: two weeks
measure: sensitive check
timeFrame: two weeks
measure: Abnormal Frenum Attachment
timeFrame: a week
measure: Probing depth
timeFrame: six months
Secondary outcomes:
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
Study officials:
References:
Clinical trial NCT02451644: The Association Between Physical Activity and Pregnancy Rate Following Embryo Transfer
Official title: The Association Between Physical Activity and Pregnancy Rate Following Embryo Transfer
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pregnancy
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2015-05-22
Enrollment: 200
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The study examines the association between the amount of physical activity of the patient, ie the number of steps daily / weekly, and the pregnancy rate after embryo transfer.

Detailed description: Many studies have investigated the matter until today and still no reliable information about the relationship between physical activity and / or its intensity and the pregnancy rate after embryo transfer.

All patients that would take part in the study will be given a pedometer to measure steps for a month.

Measuring steps will begin preparation for embryo transfer and two weeks after. Collected information about pregnancy rate (BHCG positive or negative).

Eligibility criteria: Inclusion Criteria:

* Participant speaks Hebrew or English speakers
* The participant is eligible to legally provide informed consent

Exclusion Criteria:

* The Subject in the wheelchair-bound or limited walking
* Participant refuses to give informed consent

Primary outcomes:
measure: Physical activity as assessed by number of steps recorded by pedometer
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Ramat Gan
country: Israel
facility: Shalom Mazaki tovi
Study officials:
References:
Clinical trial NCT05944744: The Role of Cobamamide Supplements in Malnourished Patients
Official title: The Role of Cobamamide Supplements in Malnourished Patients
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Malnutrition
Lead sponsor: Fakultas Kedokteran Universitas Indonesia
Sponsor class: OTHER
Collaborators: name: Interbat Pharmaceuticals
First posted: 2023-07-13
Enrollment: 124
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The trial is conducted to observe the effectiveness of cobamamide supplements in improving the clinical state malnourished patients.


Eligibility criteria: Inclusion Criteria:

* 18 - 70 years old
* Diagnosis of malnutrition based on 2019 GLIM criteria
* Participant agree to join the trial by signing infomed consent.

Exclusion Criteria:

* Malignancy (ECOG IV) and bowel obstruction
* Patients who unable to tolerate oral intake and in total parenteral nutrition
* Bowel disorder that caused severe malabsorbtion
* Patients who refuse to join the trial

Primary outcomes:
measure: Change of Appetite
timeFrame: 28 days
measure: Nutritional Status
timeFrame: 28 days
measure: Bioimpendance Analysis Result
timeFrame: 28 days
measure: Vitamin B12 (1)
timeFrame: 28 days
measure: Vitamin B12 (2)
timeFrame: 28 days
measure: Pre-albumin
timeFrame: 28 days
measure: Laboratory result (1)
timeFrame: 28 days
measure: Laboratory result (2)
timeFrame: 28 days
measure: Laboratory result (3)
timeFrame: 28 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02173444: Comparison of the Accuracy and Reliability of AMH, FSH and AFC in Predicting Ovarian Response
Official title: Comparison of the Accuracy and Reliability of AMH, FSH and AFC in Predicting Ovarian Response
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Infertility
Keywords: in-vitro fertilization
ovarian stimulation
Lead sponsor: Vietnam National University
Sponsor class: OTHER
First posted: 2014-06-25
Enrollment: 820
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Serum bio-markers have different prediction values for ovarian response during ovarian stimulation in-vitro fertilization


Eligibility criteria: Inclusion Criteria:

* Age ≤ 45 years at the time of FSH starting
* BMI \< 25 kg/m2,
* First IVF attempt
* Receiving GnRH-antagonist protocol
* Had oocyte retrieval

Exclusion Criteria:

* Had ovarian stimulation or ovulation induction within 2 months prior to the study
* PCOS
* Had ovarian tumor or endometrioma
* Hyperprolactinemia
* Thyroid hormone disorders
* Pituitary failure
* Had other medical situations such as liver failure, renal failure, heart disease, diabetes, depression
* Had IVM

Primary outcomes:
measure: Number of oocytes
timeFrame: At the time of oocyte retrieval
measure: number of oocytes at time of oocyte retrieval
timeFrame: up to 14 days
Secondary outcomes:
Other outcomes:
Locations:
city: Ho Chi Minh City
country: Vietnam
facility: An Sinh Hospital
state: Ho Chi Minh
Study officials:
References:
Clinical trial NCT06204744: Home-based Arm and Hand Exercise Program for Stroke: A Multisite Trial
Official title: Scale-out of a Home-based Arm and Hand Exercise Program for Stroke: A Multisite Implementation-efficacy Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Stroke
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2024-01-12
Enrollment: 143
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this multisite clinal trial is to evaluate the implementation of the home-based Graded Repetitive Arm Supplementary Program (GRASP) at rehabilitation clinics across several hospitals. The main questions it aims to answer is:

• the efficacy of the home-based GRASP program relative to the conventional occupational therapy intervention on improving health outcomes, including UE motor function, daily function, quality of life, and motor control strategies.

Stroke participants will be randomly assigned to either the Home-based GRASP group or the conventional occupational therapy home program group. Each group will undergo an 4 to 6-week intervention (3 sessions/week) with evaluations conducted before, immediately after, and 3 months post-trial, assessing clinical and kinematic measures. Interviews and surveys will be conducted to gain insights into the perspectives of patients regarding the implementation of the home-based GRASP program.


Eligibility criteria: Inclusion Criteria:

* are aged 20 years or older
* have upper extremity hemiparesis due to the first-ever stroke
* have some voluntary movement in the affected UE
* are able to follow 2-step instructions

Exclusion criteria:

* orthopedic conditions affecting the arm/hand or other neurological conditions
* severe pain that prevents movement in the affected arm and hand
* unstable medical status

Primary outcomes:
measure: Fugl Meyer Assessment (upper extremity)
timeFrame: Baseline, post-test (1 month after baseline), 3-month followup
Secondary outcomes:
Other outcomes:
Locations:
city: Chiayi City
country: Taiwan
facility: Chiayi Chang Gung Memorial Hospital
Study officials:
affiliation: Chang Gung University
name: Chieh-ling Yang
role: PRINCIPAL_INVESTIGATOR
References: