Clinical trial NCT06375395: Boosting The Intervention Effect of Negative Memory Through tACS Stimulation
Official title: Research on Improving the Intervention Effect of Negative Memory Through tACS Enhanced Memory Technology
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Seizures
Keywords: seizure
transcranial alternating current stimulation
neuromodulation
negative memory
neural mechanisms
retrieval practice
working memory
Lead sponsor: Xuanwu Hospital, Beijing
Sponsor class: OTHER
Collaborators: name: Beijing Normal University
First posted: 2024-04-19
Enrollment: 60
Sex: ALL
Minimum age (years): 14
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objectives of this study include: 1) investigating the impact of negative memory substitution on an individual's other intellectual memories (i.e., neutral memories) and the underlying neurocognitive mechanisms; 2) investigating the memory enhancement effect resulting from retrieval practice associated with memory substitution intervention along with an examination of the neurocognitive mechanisms responsible for this enhancement.

Detailed description: This study will adopt two memory updating strategies: retrieval practice and reactivation.

A 5-day memory updating experimental paradigm is used.

1. On the first day, the old memory A-B linkage is learned, where A represents a neutral word and B is either neutral or negative pictures (half of each, randomly scrambled).
2. On the second day, the old memory A-B association is consolidated again, and after a 15-minute break, the new memory A-C association is learned, where A is still the word A used in the old memory A-B association on the first day, and C is the new neutral and negative pictures (half of each, randomly scrambled, and with inconsistent categories of C and B in each pair of AC and AB). Immediately following this, the new memories of the A-C conjunctions are updated using both Retrieval practice and Restudy (control condition) memory strategies.
3. A-C is extracted/learned using both Retrieval practice and Restudy memory strategies on both day 3 and day 4.
4. On the fifth day, memory tests for associative memory strength, gist and detail memory, as well as emotional valence and strength are performed.

Eligibility criteria: Eligibility

Inclusion Criteria:

1. 14-60 years old, male or female, Han Chinese;
2. Drug-resistant epilepsy;
3. Required surgical implantation of SEEG electrodes.

Exclusion Criteria:

1. Progressive encephalopathy or progressive structural damage in the central nervous system;
2. Significant heart, liver, renal insufficiency, and other medical diseases;
3. Severe side effects from taking antiepileptic drugs at the time of enrollment and not inappropriate for SEEG;
4. Significant intellectual disability;
5. A history of alcohol and drug abuse;
6. Any contraindication to MRI.

Primary outcomes:
measure: Negative memory retention
timeFrame: Day 5
Secondary outcomes:
measure: The negative emotional intensity of negative memory
timeFrame: Day 5
measure: The retention of associated neutral memories as assesses by the proportions of responses of correctly choosing picture category of B picture (A-Bneu) in last A-B paired associate memory test
timeFrame: Day 5
measure: The negative emotional intensity of neutral memory
timeFrame: Day 5
Other outcomes:
Locations:
Study officials:
affiliation: Xuanwu Hospital, Beijing
name: Guoguang Zhao
role: STUDY_DIRECTOR
References: