Clinical trial NCT03927638: Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements
Official title: Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Overweight and Obesity
Lead sponsor: Montclair State University
Sponsor class: OTHER
First posted: 2019-04-25
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Healthy subjects between the ages of 18 and 50 years.

Brief summary: This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.

Detailed description: The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.

Eligibility criteria: Inclusion Criteria:

* healthy adult

Exclusion Criteria:

* Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions.
* Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
* Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time.
* Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
* Are pregnant or trying to become pregnant.
* Are not between 18 and 50 years of age.

Primary outcomes:
measure: Heart Rate
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
measure: Systolic Blood Pressure (SBP)
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
measure: Diastolic Blood Pressure (DBP)
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
measure: Oxygen Consumption
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
measure: Carbon Dioxide Production
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
measure: Ventilation
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
measure: Respiratory Exchange Ration (RER)
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
Secondary outcomes:
measure: Height
timeFrame: 1 minute
measure: Weight
timeFrame: 1 minute
measure: Body Mass Index (BMI)
timeFrame: 1 minute
measure: Body Composition
timeFrame: Approximately 15 minutes
measure: Total Peripheral Resistance (TPR)
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
measure: Stroke Volume
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
measure: Cardiac Output (Q)
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
measure: Muscle Oxygen Saturation
timeFrame: Approximately 15 minutes in each condition (sitting and standing)
Other outcomes:
Locations:
city: Montclair
country: United States
facility: Montclair State University
state: New Jersey
Study officials:
References:
citation: Hosick PA, Willett JM, Matthews EL. Cardiovascular strain and metabolic rate are higher following 15 minutes of standing versus seated computer work. Eur J Prev Cardiol. 2020 Dec;27(19):2131-2133. doi: 10.1177/2047487319867402. Epub 2019 Jul 29. No abstract available.