Clinical trial NCT06220110: Probiotic Supplementation on Sport Performance and Gut Damage in Females
Official title: Effects of Probiotic Supplementation on Sport Performance and Gut Damage in Females CrossFit Athletes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sport Performance
Gut Damage
Keywords: Probiotic
Gut damage
Sport performance
Females
Lead sponsor: University of the Basque Country (UPV/EHU)
Sponsor class: OTHER
First posted: 2024-01-23
Enrollment: 10
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This study will be performed with the aim to evaluate the effects of probiotic supplementation on sport performance and gut damage. Participants will be divided into two groups, placebo and experimental group. With the purpose to assess the effects of probiotics on the gut damage, a strenuous exercise session will be performed, and then blood samples will be taken to observe the variation of the selected intestinal damage marker. 24 hours after this strenuous session, performance tests will be performed. After the 4 weeks of supplementation, the same procedure will be followed to evaluate the effect of probiotics.

Detailed description: One week before the initiation of the study participants will be required to avoid consuming drugs, alcohol, cigarettes, probiotics, and any other food or liquid which could modify gut microbiota composition. For the baseline values, height, weight and sports performance test, of the participants will be collected. The same day, a strenuous exercise session will be performed in order to observe the variation of the intestinal damage marker (blood sample extraction just after finishing the strenous exercise session). 24 hours after that session sport performance tests will be conducted. Participants will then be randomly divided into two groups, one of which will take one probiotic capsule per day containing 10 billion colony-forming units (CFU) of Lactobacillus plantarum, and the other group will take one placebo capsule per day consisting of dextrose. The supplementation period will last 4 weeks.

After the supplementation period, the same process will be followed, with the same strenuous exercise session and immediate blood sampling to determine the effects of probiotics on the intestinal damage caused by exercise. 24 hours later, performance tests will be conducted to assess the effects of probiotics on sport performance.

Eligibility criteria: Inclusion Criteria:

* Healthy
* No injuries
* 1 year of CrossFit practicing experience

Exclusion Criteria:

* Drug, alcohol, cigarettes, probiotic intake
* Injuries

Primary outcomes:
measure: Intestinal-fatty acid-binding protein
timeFrame: 0-10 minutes after strenuous exercise blood samples will be extracted
measure: Counter movement jump test
timeFrame: 24 hours after strenuous training session. First test to be performed
measure: Running Based Anaerobic Sprint Test
timeFrame: 24 hours after strenuous training session. Second test to be performed
measure: YO YO Intermittent Recovery Level test 1
timeFrame: 24 hours after strenuous training session. Third test to be performed
Secondary outcomes:
Other outcomes:
Locations:
city: Vitoria
country: Spain
facility: CrossFit Bikain
state: Alava
Study officials:
affiliation: University of the Basque Country (UPV/EHU)
name: Asier Santibañez, MsC
role: PRINCIPAL_INVESTIGATOR
References: