Clinical trial NCT06584695: Analgesic Efficacy of External Oblique Intercostal Block vs Subcostal Transversus Abdominis Plane Block in Open Surgical Nephrectomy
Official title: Analgesic Efficacy of External Oblique Intercostal Block Versus Subcostal Transversus Abdominis Plane Block in Open Surgical Nephrectomy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Analgesic Efficacy
External Oblique Intercostal Block
Subcostal Transversus Abdominis Plane Block
Open
Nephrectomy
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-09-05
Enrollment: 63
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the efficacy of unilateral ultrasound-guided oblique subcostal transversus abdominis plane block with unilateral ultrasound-guided external oblique intercostal plane block in providing intraoperative and postoperative analgesia in cancer patients undergoing open nephrectomy.

Detailed description: Open surgery remains one of the procedures used for those patients requiring partial or radical nephrectomy and is associated with a high incidence of severe immediate postoperative pain and chronic pain the months following surgery.

Regional anesthesia techniques are frequently recommended for pain control in open nephrectomy as they decrease the need for parenteral opioid and improve patient satisfaction.

Although abdominal wall blocks are known to decrease opioid requirements without causing epidural associated hypotension, their role in flank surgeries has been less well-established. The dermatomes that need to be covered in flank incision are T9 to T11.

Studies have confirmed that ultrasound-guided (USG) transversus abdominis plane (TAP) block is an effective method of analgesia for upper abdominal surgeries, lower abdominal surgeries and kidney transplantation with minimal side effects.

The external oblique intercostal (EOI) block is a novel method providing simple and effective somatic analgesia to the upper abdomen with minimal side effects. Other advantages include easy sonoanatomy (even in obese patients), being performed in the supine position, and no anticoagulation concern

Eligibility criteria: Inclusion Criteria:

* Age (18-65) year.
* Both sexes.
* American Society of Anesthesiologists (ASA) class II and III.
* Cancer patients candidate for open nephrectomy .

Exclusion Criteria:

* Patient refusal.
* Skin lesions or infection at the site of proposed needle insertion.
* Cognitive disorders.
* History of psychiatric disorders or drug abuse.
* Patients allergic to medication used.
* ASA class IV.
* Coagulopathy.
* Body mass index (BMI) more than 35.

Primary outcomes:
measure: Degree of pain
timeFrame: 24 hours after surgery
Secondary outcomes:
measure: Mean arterial pressure
timeFrame: Till the end of surgery (up to 2hours)
measure: Heart rate
timeFrame: Till the end of surgery (up to 2hours)
measure: Opioids consumption
timeFrame: 24 hours after surgery
measure: Morphine consumption
timeFrame: 24 hours after surgery.
measure: Time to rescue analgesia.
timeFrame: 24 hours after surgery
measure: Incidence of complications
timeFrame: 24 hours after surgery
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
Study officials:
References: