Clinical trial NCT06757712: Periodization Resistance Training on Quality of Life in Females With Hypothyroidism
Official title: Nonlinear Versus Linear Periodized Resistance Training on Quality of Life in Females With Hypothyroidism
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Hypothyroidism
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-01-03
Enrollment: 75
Sex: FEMALE
Minimum age (years): 35
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will be conducted to compare between the effect of nonlinear and linear periodized training on quality of life in females with hypothyroidism.

Detailed description: Worldwide, the incidence of individuals with thyroid dysfunction is increasing and represents approximately 30-40% of the patients seen in an endocrine clinic; thus, it is one of the leading endocrine disorders.The undiagnosed thyroid dysfunction especially subclinical and clinical hypothyroidism may increase cardiovascular risk factors.

The prevalence of hypothyroidism depends on many factors, such as age, sex and geographical factors. It's also a diet related disorder and it's usually seen when the daily intake of iodine falls below 25μg.

Hypothyroidism tends to affect women more often than men and can manifest at any age, typically observed between 40 and 70 years. No specific racial predilection has been identified in studies regarding this condition. regular exercise can improve quality of life in patients with subclinical hypothyroidism by increasing physical activity level/fitness and reducing the signs and symptoms of the disease. Exercise may therefore potentiate the effectiveness of levothyroxine and help hypothyroid individuals improve their quality of life.

Periodization of resistance training or planned changes in training volume and intensity are used to maximize strength and fitness gains. The most common of periodized resistance training plans is linear also termed classic or strength/power periodization and nonlinear periodization. The biggest difference between these two types of training plans is with nonlinear periodization changes in training volume and intensity are made more frequently. The most common type of nonlinear periodization is daily nonlinear periodization where substantial changes in training intensity and volume are made from one training session to the next training session.

So, this study will be conducted to compare between the effect of non linear and linear periodized resistance training on quality of life in females with hypothyroidism.

Eligibility criteria: Inclusion Criteria:

* Be controlled hypothyroidism (TSH level within 0.5 - 4.5 mU/L)
* Be ranged from 35 to 45 years
* Female patients
* Body Mass Index 30-34.9 kg/m2 .
* triglyceride-glucose (TyG) index \> 4.5

Exclusion Criteria:

* history of pulmonary disease
* Patients with uncontrolled coronary or cerebrovascular disease
* Those who underwent musculoskeletal surgery within the previous year
* Recent history of lower and upper limb fracture , hip and shoulder dislocation.
* Cognitive impaired patients
* Patients with history of epilepsy
* Patients who participating in any other exercise program

Primary outcomes:
measure: Serum thyroid stimulating hormone (TSH) level
timeFrame: 12 weeks
measure: FreeT4 (thyroxine) level
timeFrame: 12 weeks
measure: FreeT3 (tri-iodothyronine) level
timeFrame: 12 weeks
measure: Health related Quality of life questionnaire
timeFrame: 12 weeks
Secondary outcomes:
measure: Triglyceride-glucose (TyG) index
timeFrame: 12 weeks
measure: Quadriceps strength
timeFrame: 12 weeks
measure: Hand grip strength
timeFrame: 12 weeks
measure: 9-item Fatigue Severity Scale (FSS)
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Suez
country: Egypt
facility: Suez University
Study officials:
affiliation: Professor, Cairo university
name: Nesreen Gharib Mohamed Elnahas, PhD
role: STUDY_CHAIR
References: