Clinical trial NCT04564794: Prognostic Value of Cardial Stress Perfusion Imaging
Official title: Prognostic Value of Low Irradiation Cardiac Stress Perfusion Scans
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
Keywords: coronary
myocardial perfusion tomoscintigraphy.
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2020-09-25
Enrollment: 11952
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Any coronary patient suspected or proven to have had a stress myocardial perfusion tomoscintigraphy performed at the Nancy CHRU and corresponding to a standardized model of expression of results (i.e. more than 10,000 reports).

Brief summary: Stress myocardial perfusion scintigraphy is a reference examination for the detection and monitoring of coronary patients, and this examination has already been the subject of multiple validation studies, including for the stratification of the prognosis of these patients, information that can usefully guide therapeutic choices.

Today, this reduction in the activity of injected radiopharmaceuticals is taking place in a growing number of nuclear medicine departments.

The implications are unknown in terms of the risk of death of the different parameters studied

Detailed description: Stress myocardial perfusion scintigraphy is a reference examination for the detection and monitoring of coronary patients, and this examination has already been the subject of multiple validation studies, including for the stratification of the prognosis of these patients, information that can usefully guide therapeutic choices (medical treatment, myocardial revascularization, ...). The arrival of new solid-state cameras has been a real technological leap for this examination, making it possible to significantly improve the quality of the images and also to drastically reduce the activities of injected radiopharmaceuticals and thus the exposure of patients and staff to ionizing radiation. Today, this reduction in the activity of injected radiopharmaceuticals is taking place in a growing number of nuclear medicine departments. The injected activities are reduced up to a third of those injected in the past (this is indeed the case in the population we propose to study).

However, the value of the prognostic stratification obtained with stress myocardial perfusion scans recorded with low activity on semiconductor cameras is not yet known. In particular, the implications are unknown in terms of the risk of death of the different parameters studied (normal or abnormal examination, extent of myocardial ischemia and infarction sequelae, impact on left ventricular function in post-stress and resting states, etc.).

Eligibility criteria: Inclusion Criteria:

* Any coronary patient suspected or proven to have had a stress myocardial perfusion tomoscintigraphy performed at the Nancy CHRU and corresponding to a standardized model of expression of results (i.e. more than 10,000 reports).

Exclusion Criteria:

* None

Primary outcomes:
measure: Overall mortality
timeFrame: 6 months
Secondary outcomes:
measure: Death from cardiac causes, either proven or suspected (death from unexplained causes),
timeFrame: 6 months
measure: Major cardiac events (death of proven or suspected cardiac cause, myocardial infarction, myocardial revascularization procedure),
timeFrame: 6 months
measure: Cardiac mortality and major cardiac events.
timeFrame: 6 months
Other outcomes:
Locations:
city: Vandœuvre-lès-Nancy
country: France
facility: Nancy Hospital
state: Grand Est
Study officials:
affiliation: Nancy CHRU hospital
name: Pierre-Yves Marie, MD, PhD
role: STUDY_DIRECTOR
References: