Clinical trial NCT03414281: TMQLB Versus TPVB for Acute Pain and Quality of Recovery After Laparoscopic Renal Surgery
Official title: Transmuscular Quadratus Lumborum Block Versus Thoracic Paravertebral Block for Acute Pain and Quality of Recovery After Laparoscopic Renal Surgery
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Nerve Block, Nephrectomy, Analgesia
Keywords: quadratus lumborum block, thoracic paravertebral block, nephrectomy
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2018-01-29
Enrollment: 30
Sex: ALL
Minimum age (years): 17
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This trial is a prospective, randomized, single-center, open-label, parallel-arm, blinded-analysis trial, the objective of which is to evaluate the effect of transmuscular quadratus lumborum block (TMQLB) in the pain relief and quality of recovery in laparoscopic renal surgery compared with thoracic paravertebral block (TPVB).


Eligibility criteria: Inclusion Criteria:

* 17\~80 years of age;
* American Society of Anesthesiologists physical status I-III;
* undergoing laparoscopic nephrectomy.

Exclusion Criteria:

* have a known allergy to the anesthetics being used;
* infection at injection site
* coagulopathy or history of anticoagulants use
* chronic analgesics consumption or history of substance abuse
* inability to properly describe postoperative pain or recovery to investigators (e.g., language barrier, neuropsychiatric disorder).

Primary outcomes:
measure: mean VAS of the first postoperative 24 hours
timeFrame: within the first 24 postoperative hours
Secondary outcomes:
measure: cumulative morphine consumption
timeFrame: at 0, 2,4, 8, 12, 24 ,48, 72hours and 7 day after the surgery
measure: long-term pain control
timeFrame: at 48, 72 and 7 days after the surgery
measure: dermatomal distribution of sensory loss
timeFrame: 10, 20, 30 and 40 minutes after the intervention
measure: nausea score
timeFrame: at 0, 2, 4, 8, 12, 24 and 48 hours after the surgery;
measure: pruritus score
timeFrame: at 0, 2, 4, 8, 12, 24 and 48 hours after the surgery;
measure: ambulation time
timeFrame: after the surgery
measure: time of recovery of bowel movement
timeFrame: after the surgery
measure: quality of recovery evaluated by the self-assessment 15-item quality of recovery (QoR) scale
timeFrame: at 3 days and 5 days after the sugery
measure: postoperative length of hospital stay
timeFrame: after the surgery
measure: patient satisfaction with anesthesia
timeFrame: at 48 hours after the surgery
Other outcomes:
Locations:
city: Beijing
country: China
facility: Xulei CUI
state: Beijing
Study officials:
affiliation: Peking Union Medical College Hospital
name: Yuguang Huang
role: STUDY_CHAIR
References:
citation: Yuan Q, Cui X, Fei Y, Xu Z, Huang Y. Transmuscular quadratus lumborum block versus thoracic paravertebral block for acute pain and quality of recovery after laparoscopic renal surgery: study protocol for a randomized controlled trial. Trials. 2019 May 20;20(1):276. doi: 10.1186/s13063-019-3359-7.