Clinical trial NCT04560608: Elucidating the Symptomatic, Explanatory and Prognostic Characteristics of GERIAtric Patients Hospitalized for COVID-19
Official title: Elucidating the Symptomatic, Explanatory and Prognostic Characteristics of GERIAtric Patients Hospitalized for COVID-19
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Covid19
Keywords: elderly
coronavirus disease
Lead sponsor: University Hospital, Angers
Sponsor class: OTHER_GOV
First posted: 2020-09-23
Enrollment: 700
Sex: ALL
Minimum age (years): 70
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: All consecutive patients meeting the eligibility criteria over the study period.

Brief summary: Statement :

* The emerging Coronavirus 2019 (COVID-19) disease, linked to the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pathogen, has been spreading worldwide since December 2019, affecting millions of people and causing hundreds of thousands of deaths, particularly among the elderly.
* The first epidemiological evidence available reveals a different expression of the disease in the elderly, associated with a high risk of delayed diagnosis and implementation of protective measures and a particularly high morbidity and mortality, especially among the frailest.
* To date, there is no effective model for predicting the severity of COVID-19 in an individual.

The investigators hypothesize that there are specificities of COVID-19 in the elderly, both etiological, diagnostic and prognostic, all of which are not yet known and understood.


Eligibility criteria: Inclusion Criteria:

* Hospitalization in the Geriatric unit of the University Hospital (UH) of Angers from 15/03/2020 and until the closure of the COVID-19 geriatric sector

Exclusion Criteria:

* Opposition to the use of the information collected for research purposes.

Primary outcomes:
measure: Medical history and co-morbidities
timeFrame: baseline
measure: The physical examination data, and reports of relevant investigations data provided by the physician and the family during hospitalization
timeFrame: baseline
measure: Electrocardiography QT Interval
timeFrame: baseline
measure: Number of different therapeutic classes
timeFrame: baseline
measure: Comprehensive Geriatric Assessment (CGA)
timeFrame: baseline
measure: Biological parameters
timeFrame: baseline
measure: Medical imaging results
timeFrame: baseline
measure: Diagnosis of COVID-19
timeFrame: baseline
measure: Length of hospitalization
timeFrame: at the 3-month follow-up
measure: Number of death from any cause
timeFrame: at the 3-month follow-up
measure: Reports of relevant investigations data provided by the physician and the family during the two-month telephone follow-up
timeFrame: at the 3-month follow-up
measure: Length of hospitalization
timeFrame: at the 12-month follow-up
measure: Number of death from any cause
timeFrame: at the 12-month follow-up
measure: Reports of relevant investigations data provided by the physician and the family during the two-month telephone follow-up
timeFrame: at the 12-month follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Angers
country: France
facility: Angers University Hospital
Study officials:
affiliation: University Hospital, Angers
name: Cédric ANNWEILER, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: