louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05694429: The Effect of the Combination of Cleanser and Moisturizer Product K
Official title: The Effect of the Combination of Cleanser and Moisturizer Product K on Skin Rejuvenation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aesthetic
Cosmetic
Healthy
Lead sponsor: Ungku Shahrin Medical Aesthetic Research & Innovation (USMARI) Centre
Sponsor class: INDUSTRY
First posted: 2023-01-23
Enrollment: 34
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This study is conducted to evaluate the effectiveness of product K cleanser and moisturizer when use in combination for skin rejuvenation. The study duration is 8 weeks and the skin assessment will be carried out at baseline, week 2, week 4 and week 8.The main questions this study aims to answer are:

1. The effect of cleanser and moisturizer K when use in combination on skin hydration.
2. The effect of cleanser and moisturizer K when use in combination on skin elasticity.
3. To observe any adverse effect occurrence with the usage of the products.


Eligibility criteria: Inclusion Criteria:

* Malaysia citizen
* Male and female (age 20-60 years old)

Exclusion Criteria:

* Participants taking isotretinoin
* Immunocompromised patients
* Participant who undergo any cosmetic procedures such as laser \& light treatment for the past three months.
* Participant with a history of facial surgery.

Primary outcomes:
measure: Change in skin hydration from baseline and at week 2, week 4 and week 8 after using product K cleanser and moisturizer
timeFrame: Baseline, week 2, week 4 and week 8
measure: Change in skin elasticity from baseline and at week 2, week 4 and week 8 after using product K cleanser and moisturizer
timeFrame: Baseline, week 2, week 4 and week 8
measure: Adverse effect after using product K cleanser and moisturizer
timeFrame: Week 8
Secondary outcomes:
Other outcomes:
Locations:
city: Petaling Jaya
country: Malaysia
facility: Ungku Shahrin Medical Aesthetic Research & Innovation (USMARI) Centre
state: Selangor
Study officials:
References:
Clinical trial NCT00870129: Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors
Official title: Using Advanced MR Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans: A Pilot Study, and to Examine Metabolite Changes in Gliomas and Other Solid Tumors
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Brain Cancer
Glioma
Keywords: brain tumor
radiation
MRI
09-009
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2009-03-27
Enrollment: 135
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The researchers think that the use of advanced MR imaging may help people with this disease, because it may better predict areas within a malignant glioma (brain tumor) that are at a high risk of recurring. WeThe reserchers are doing this study to see whether this advanced imaging is a safe treatment that causes few or mild side effects in people with brain tumors.


Eligibility criteria: Inclusion Criteria:

* Suspected or Histopathologically proven diagnosis of high grade or low glioma or tumor is suspected to harbor an isocitrate dehydrogenase (IDH) mutation
* May undergo radiation therapy
* Patient and/or guardian is able to provide written informed consent prior to study registration
* Age ≥ 18 years old

Exclusion Criteria:

* Extreme claustrophobia that precludes MRI scan
* Known allergic reaction to Gd-DTPA
* Any contraindication to gadolinium intravenous contrast as per standard Department of Radiology contrast guidelines
* Any absolute contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander).
* Pregnant or nursing female
* Unable to cooperate for MRI and/or radiation therapy planning

Primary outcomes:
measure: To assess the utility of baseline advanced MRI & changes between baseline & follow up advanced MRI in predicting high risk areas that are likely to develop progressive glioma despite chemoradiotherapy.
timeFrame: 1 -7 weeks before radiation treatment, about two months after treatment, and about every two months thereafter for the duration of the study.
Secondary outcomes:
measure: To compare radiation therapy simulations in patients with gliomas using conventional and baseline advanced MRI data.
timeFrame: prior to and 1 months±3 weeks after radiation therapy.
measure: feasibility of 2HG spectroscopy
timeFrame: 2 years
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Robert Young, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04798729: Comparison of Two Different Digital Methods in Occlusal Analysis
Official title: COMPARISON OF SENTRIC OCCLUSION DATA OBTAINED FROM TWO DIFFERENT COMPUTER-ASSISTED RECORDING METHODS
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dental Occlusion
Occlusion
Jaw Relationship
Centric Occlusion
Occlusal Analysis
Keywords: Dental Occlusion
Centric Occlusion
Occlusal Analysis
T-Scan
Cerec Omnicam
Digital Dentistry
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2021-03-15
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The groups were formed of voluntary participants from undergraduate and postgraduate students in the Dentistry Faculty of Gazi University.

Brief summary: Aim: The aim of this study is to compare the T-Scan digital occlusal analysis system and the occlusal analysis mode of the CEREC Omnicam system, which is mainly used for design/ production, using the data recorded at the centric occlusion position.

Material-Method: Occlusal recordings were obtained from healthy 20 females and 20 males aged 18-25 at the centric occlusion position. Records were saved as .jpeg format and transferred to Adobe Photoshop CS6 program. Blue, green, and red colors (shown by the same color codes in both systems) representing light, intense and tight contacts, respectively, were evaluated in terms of the pixel counts. For statistical comparison the differences between the systems Independent Sample T-Test and, between the genders, One Sample T- Test were used (α = 0.05).


Eligibility criteria: Inclusion Criteria:

* Individuals with no missing teeth (teeth numbers 18, 28, 38, 48 were excluded from the evaluation), no local or systemic disorders that could prevent the bite, and no disorder determined as a result of the TMJ examination.

Exclusion Criteria:

-

Primary outcomes:
measure: Comparing the levels of accuracy of the occlusal analysis mode included in the software of CEREC Omnicam and the T-Scan occlusal analysis system.
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazi University Faculty of Dentistry
Study officials:
affiliation: Gazi University Faculty of Dentistry
name: Evsen TAMAM, Phd, DDS, Assoc Prof Dr
role: STUDY_CHAIR
References:
citation: Bostancioglu SE, Togay A, Tamam E. Comparison of two different digital occlusal analysis methods. Clin Oral Investig. 2022 Feb;26(2):2095-2109. doi: 10.1007/s00784-021-04191-1. Epub 2021 Oct 1.
Clinical trial NCT06426329: The Effect of Therapeutic Touch At Birth on Pain, Birth Duration, Traumatic Birth Perception and Anxiety
Official title: The Effect of Therapeutic Touch At Birth on Pain, Birth Duration, Traumatic Birth Perception and Anxiety
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Pregnancy
Vaginal Delivery
Keywords: Therapeutic Touch
Labor Pain
Birth Duration
Anxiety
Traumatic Birth Perception
Lead sponsor: Cumhuriyet University
Sponsor class: OTHER
First posted: 2024-05-23
Enrollment: 66
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Aim: This study was planned to determine the effect of therapeutic touch applied at birth on pain, birth duration, traumatic birth perception and anxiety.

Detailed description: Methods: The sample of this randomized controlled experimental research consisted of 66 (intervention group: 33; control group: 33) women. Data were collected using a Personal Information Form, Visual Analogue Scale, State Anxiety Inventory and Traumatic Childbirth Perception Scale.

Eligibility criteria: Inclusion Criteria:

Not having a high-risk pregnancy Having no health problems with the baby or herself Having a single foetus Being about to have a vaginal delivery Not having a chronic physical or psychiatric diagnosis Agreeing to participate in the research Not having communication and perception problems Miad (37W\<) pregnancy Having with induction application

Exclusion Criteria:

having vacuum, forceps etc. intervention such as

Primary outcomes:
measure: Visual Analogue Scale
timeFrame: Baseline
measure: State Anxiety Inventory
timeFrame: Baseline
measure: Traumatic Birth Perception Scale
timeFrame: Baseline
Secondary outcomes:
measure: Visual Analogue Scale
timeFrame: Postpartum in 2 hour
measure: State Anxiety Inventory
timeFrame: Postpartum in 2 hour
measure: Traumatic Birth Perception Scale
timeFrame: Postpartum in 2 hour
Other outcomes:
Locations:
city: Sivas
country: Turkey
facility: Sukran Ertekin Pinar
Study officials:
affiliation: Cumhuriyet University
name: Sukran Ertekin Pinar, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05453929: Deep Neuromuscular Block on Postoperative Delirium in Lumbar Surgery
Official title: Effect of the Deep Neuromuscular Block on Postoperative Delirium in Elderly Patients Undergoing Lumbar Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lumbar Spine Disease
Lead sponsor: Korea University Guro Hospital
Sponsor class: OTHER
First posted: 2022-07-12
Enrollment: 230
Sex: ALL
Minimum age (years): 70
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The effect of deep neuromuscular blockade (NMB) during spine surgery reduced postoperative pain and bleeding in recent studies. Therefore by reducing these two factors, which were the contributing factors for postoperative delirium, deep NMB is expected to reduce the postoperative delirium. This study was designed to determine whether the deep NMB lowered the incidence of delirium after lumbar surgery.


Eligibility criteria: Inclusion Criteria:

* Aged 70 and more;
* Scheduled for an elective lumbar spine surgery;
* ASA physical status 1-3

Exclusion Criteria:

* Diagnosed neuromuscular disorder;
* Contraindications to the study drug, e. g. known allergy or hypersensitivity, hypotension, bradycardia, higher grade atrioventricular block;
* Patient with pre-existing cognitive impairment or dementia

Primary outcomes:
measure: Delirium by CAM-ICU
timeFrame: from just after surgery at the PACU to post-operative 5 days
Secondary outcomes:
measure: Intramuscular pressure
timeFrame: intraoperative
measure: Peak inspiratory airway pressure
timeFrame: intraoperative
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seok Kyeong Oh
state: Gangnam-gu
Study officials:
affiliation: Korea University Guro Hospital
name: Seok Kyeong Oh, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Morino T, Hino M, Yamaoka S, Misaki H, Ogata T, Imai H, Miura H. Risk Factors for Delirium after Spine Surgery: An Age-Matched Analysis. Asian Spine J. 2018 Aug;12(4):703-709. doi: 10.31616/asj.2018.12.4.703. Epub 2018 Jul 27.
citation: Oh SK, Kwon WK, Park S, Ji SG, Kim JH, Park YK, Lee SY, Lim BG. Comparison of Operating Conditions, Postoperative Pain and Recovery, and Overall Satisfaction of Surgeons with Deep vs. No Neuromuscular Blockade for Spinal Surgery under General Anesthesia: A Prospective Randomized Controlled Trial. J Clin Med. 2019 Apr 12;8(4):498. doi: 10.3390/jcm8040498.
citation: Kang WS, Oh CS, Rhee KY, Kang MH, Kim TH, Lee SH, Kim SH. Deep neuromuscular blockade during spinal surgery reduces intra-operative blood loss: A randomised clinical trial. Eur J Anaesthesiol. 2020 Mar;37(3):187-195. doi: 10.1097/EJA.0000000000001135.
citation: Taylor H, McGregor AH, Medhi-Zadeh S, Richards S, Kahn N, Zadeh JA, Hughes SP. The impact of self-retaining retractors on the paraspinal muscles during posterior spinal surgery. Spine (Phila Pa 1976). 2002 Dec 15;27(24):2758-62. doi: 10.1097/00007632-200212150-00004.
Clinical trial NCT06167629: Monocentric Observational Study on the Diagnostic and Prognostic Role of 18F-PSMA PET (PET/CT and PET/MR) in Prostate Cancer
Official title: Monocentric Observational Study on the Diagnostic and Prognostic Role of 18F-PSMA PET (PET/CT and PET/MR) in Prostate Cancer
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Prostate Cancer
Lead sponsor: IRCCS San Raffaele
Sponsor class: OTHER
First posted: 2023-12-12
Enrollment: 2500
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study will enroll adult patients with a histopathological diagnosis of prostate cancer undergoing PET examination with 18 F-PSMA where requested by the specialist due to clinical need at the U.O. of nuclear medicine of the San Raffaele Hospital.

Brief summary: The general objective of this retrospective and prospective study is to evaluate the diagnostic and prognostic role of a quantitative analysis of PET images with 18F-PSMA in all stages of the disease in patients with prostate cancer. To this end, both imaging parameters commonly used in clinical practice and the contribution of radiomic features will be investigated. The latter are quantitative features extracted from biomedical images, and are believed to be able to provide information, otherwise impossible to investigate, useful for the characterization of various pathologies. This methodology is very promising, but also recent and therefore little studied and standardized. Our objective is also to investigate how to optimize it from a purely methodological point of view.

Detailed description: In this study, all PET images with 18F-PSMA will be considered, but also the CT or MR images associated with them to allow better anatomical localization.

This study will allow us to investigate the diagnostic and prognostic role of l8F-PSMA PET, also evaluating its predictive value in terms of disease course, development of metastases and mortality. The retrospective part of this protocol is necessary for the acquisition of a sufficiently large amount of data to guarantee adequate statistical power for the study.

Eligibility criteria: Inclusion Criteria:

* adult male patients;
* patients with histopathological diagnosis of prostate cancer undergoing staging or restaging;
* patients with clinical indication for PET examination with 18 F-PSMA;

Exclusion Criteria:

* medical conditions that do not allow the acquisition of PET images;
* allergic reactions to iodinated contrast medium or creatinine levels \>2mg/dL.

Primary outcomes:
measure: PET with 18F-PSMA for diagnostic accuracy for staging of prostate cancer.
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Milano
country: Italy
facility: IRC
Study officials:
References:
Clinical trial NCT01247129: Delaying the Superficial Inferior Epigastric Artery (SIEA) Flap and Determining the Change in SIEA Diameter and Blood Flow
Official title: Delaying the Superficial Inferior Epigastric Artery (SIEA) Flap: A Solution to the Problem of the Small Caliber of the Donor Artery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Breast Neoplasms
Keywords: Superficial inferior epigastric artery flap, delay phenomenon
Lead sponsor: University Medical Centre Ljubljana
Sponsor class: OTHER
Collaborators: name: University Medical Centre Maribor
First posted: 2010-11-24
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether delaying the superficial inferior epigastric artery (SIEA) flap results in widening of diameter and enhancing of blood flow of its donor artery.


Eligibility criteria: Inclusion Criteria:

* patients undergoing surgery for lower extremities varicose veins

Exclusion Criteria:

* patients who previously underwent operations of the lower abdomen (abdominoplasty and inguinal hernia repair)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Maribor
country: Slovenia
facility: University Medical Centre Maribor
Study officials:
References:
citation: Gregoric M, Flis V, Milotic F, Mrda B, Stirn B, Arnez ZM. Delaying the superficial inferior epigastric artery flap: a solution to the problem of the small calibre of the donor artery. J Plast Reconstr Aesthet Surg. 2011 Sep;64(9):1181-6. doi: 10.1016/j.bjps.2011.04.009. Epub 2011 May 10.
Clinical trial NCT02203929: Preoperative Progression of Macular Holes
Official title: Preoperative Progression of Macular Holes Using Optical Coherence Tomography
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Macular Holes
Keywords: Macular Holes
Progression
Lead sponsor: Glostrup University Hospital, Copenhagen
Sponsor class: OTHER
First posted: 2014-07-30
Enrollment: 37
Sex: ALL
Minimum age (years): 40
Maximum age (years): 120
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Tertiary Ophthalmic University Center

Brief summary: Knowledge of the natural history and progression of macular holes is mainly limited to the studies from the pre-optical coherence tomography era. By observing macular holes preoperatively we are able to determine the extent of the preoperative macular hole progression.

At our institution macular holes are treated in an elective setting. The majority of macular holes undergo a 2-step sequence of phacoemulsification and intraocular lens implantation followed by vitrectomy.

We wish to observe the effect of time and cataract surgery on the progression of macular holes prior to vitrectomy.


Eligibility criteria: Inclusion Criteria:

* Idiopathic macular hole stage II-IV
* Informed consent
* Duration of symptoms ≤ 24 months

Exclusion Criteria:

* Previous vitreomacular surgery
* Ocular trauma
* Significant visual function affecting disease (proliferative diabetic retinopathy, diabetic macular edema, exudative macular degeneration)

Primary outcomes:
measure: Macular hole Progression
timeFrame: 3 months preoperative
Secondary outcomes:
measure: Early Treatment Diabetic Retinopathy Study (ETDRS) Visual Acuity
timeFrame: 3 months postoperative
Other outcomes:
Locations:
city: Glostrup
country: Denmark
facility: Glostrup Hospital, University of Copenhagen
Study officials:
affiliation: Glostrup University Hospital, Copenhagen
name: Morten la Cour, DMSc
role: STUDY_DIRECTOR
References:
Clinical trial NCT06754280: An Intervention to Reduce Sedentary Behavior for Black Adults With Chronic Kidney Disease
Official title: Developing a Sedentary Reducing Intervention for Black Adults With CKD: RESET-CKD
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Chronic Kidney Disease(CKD)
Keywords: Sedentary
Lead sponsor: University of Illinois at Chicago
Sponsor class: OTHER
Collaborators: name: National Institute of Nursing Research (NINR)
First posted: 2024-12-31
Enrollment: 40
Sex: ALL
Minimum age (years): 35
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: RESET-CKD is evaluating an intervention to support Black adults with chronic kidney disease (CKD) to reduce their sedentary (e.g., sitting) time. Half of the participants will be randomized to the intervention, where the goal is to support individuals to reduce their sitting time, and the other half will be randomized to an attention control condition that provides CKD-related education not related to sedentary behavior. All participants will be followed for 12 weeks.


Eligibility criteria: Inclusion Criteria:

* Self-identifies as Black or African American
* Age ≥35 to ≤80 years old
* CKD Stage 1-4
* Self-reported 6 or more hours/day of sedentary time
* Ability to speak/read/understand English
* Has access to a telephone

Exclusion Criteria:

* Being unable to walk 1 block
* Being unable to stand from a seated position without assistance
* Using a wheelchair, walker, or cane for all of their ambulation
* Presence of a condition(s) or diagnosis, either physical or psychological, that precludes participation, including: Lower-extremity amputation (AKA or BKA) without prosthetic, Orthopedic condition that would preclude prompted sit-to-stand transitions or standing, Neurologic or psychiatric condition that would preclude prompted sit-to- stand transitions or standing, Severe cognitive impairment, Unstable coronary artery disease (i.e., angina with activity), Orthostatic hypotension
* Kidney transplant
* Any other condition that the investigator considers precludes participation in the trial
* Participated in the Patient Advisory Board

Primary outcomes:
measure: Change in sedentary time
timeFrame: Baseline to week 12
Secondary outcomes:
measure: Change in self-reported sedentary time
timeFrame: Baseline to week 12
measure: Change in health-related quality of life
timeFrame: Baseline to week 12
Other outcomes:
Locations:
city: Chicago
country: United States
facility: UI Health/University of Illinois Chicago
state: Illinois
Study officials:
References: