Clinical trial NCT01693081: Phase IIa Multicentre Study Investigating of VR040 in Parkinson's Disease
Official title: A Clinic-Based, Phase IIa, Double-Blind, Placebo- Controlled, Ascending-Dose, Multicentre Study of Safety, Tolerability, Efficacy and Pharmacokinetics of VR040 in Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Parkinson's Disease
Keywords: Parkinson's disease
inhaled apomorphine
convert "off" to "on"
Lead sponsor: South Glasgow University Hospitals NHS Trust
Sponsor class: OTHER
Collaborators: name: Vectura Limited
First posted: 2012-09-26
Enrollment: 47
Sex: ALL
Minimum age (years): 30
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: 'Off periods' where people with Parkinson's disease are slow, stiff and unable to function are disabling, and a treatment which can converts people to a "on", good, able to function state would be extremely useful. We assessed safety, tolerability and efficacy of inhaled dry powder apomorphine (VR040) in a clinic-based study in this setting.

Detailed description: Background: 'Off' periods increase as Parkinson's disease progresses and the benefits of standard therapy wane. Subcutaneous apomorphine rescues 'off' periods, but patient self-injection and adverse cutaneous effects are sometimes problematic.

Methods: We assessed safety, tolerability and efficacy of inhaled dry powder apomorphine (VR040) in a clinic-based Phase II study. Of 48 patients recruited at 9 sites, 47 were randomized 2:1 inhaled apomorphine:placebo. Respirable doses (drug predicted to reach the lung) ascending through 1.5mg, 2.3mg, 3.0mg, and 4.0mg until efficacy was achieved, were administered to patients in a practically defined 'off' state. The primary endpoint was the response in unified Parkinson's disease rating scale Part 3 (UPDRS 3), at the highest dose received by the patient. Secondary endpoints included time to 'on', the proportion of patients converting from 'off' to 'on', and pharmacokinetics.

Eligibility criteria: Inclusion Criteria:

1. Male or female between 30 and 90 years old with idiopathic PD for at least 5 years.
2. Voluntary written informed consent provided.
3. Willing and able to comply with study procedures.
4. Fulfilled steps 1 and 2 of the UK Brain Bank Criteria.
5. Classified as Hoehn and Yahr Stage II to IV in "on" state.
6. Motor fluctuations with recognisable "off" periods in control of motor symptoms, as assessed by the Motor Fluctuation Questionnaire.
7. Optimised oral therapy.
8. Dopaminergic responsiveness as defined by ≥ 30% improvement(reduction) in UPDRS III score compared with pre-dose value.

Exclusion Criteria:

1. Participated in a trial with an investigational product within prior 3 months.
2. Serious uncontrolled disease including serious psychological disorders.
3. Previous intolerance to apomorphine.
4. Previous significant complication from oral dopamine agonist therapy
5. Women lactating, pregnant or of child-bearing potential not using a reliable contraceptive method (eg, barrier, intrauterine device, abstinence).
6. Known HIV or active chronic hepatitis B or C infection.
7. Any clinically significant abnormality following review of screening observations
8. Patients who, in the Investigator's opinion, were unsuitable for the study for any reason.
9. Major ECG abnormalities.
10. Patients with a FEV1 ≤ 65% predicted.
11. Patients showing a postural decrease in systolic blood pressure (BP) of ≥20 mm Hg or showing significant clinical symptoms associated with orthostatic hypotension.
12. Patients with persistent arterial hypotension, with average systolic readings of ≤110 mm Hg.
13. Patients with persistent elevation of BP, with average systolic readings of ≥160 mm Hg.

    or average diastolic readings of ≥100 mm Hg.
14. Patients taking apomorphine at any time during these study visits, anabolic steroids,traditional antipsychotics (unless low dose) and vasodilators other than for the treatment of hypertension. The following atypical antipsychotics were permitted: Quetiapine (up to and including 50 mg per day), risperidone (up to and including 1 mg per day) and olanzapine (up to and including 2.5 mg per day).
15. Patients taking agents of the 5HT3 antagonist class including ondansetron, granisetron,dolasetron, palonosetron and alosetron.
16. Patients with existing cancer and those in remission for less than 5 years.
17. Patients with evidence (as ascertained from examination, tests or history) to indicate cardiovascular, gastrointestinal tract, liver, kidney, central nervous system, pulmonary system or bone marrow disorders that in the Investigator's opinion compromised patient safety.
18. Patients who were known non-responders to apomorphine treatment for "off" episodes(eg, in previous challenge tests or trials).
19. Patients with a history of drug or alcohol abuse in the 12 months prior to entry.
20. Patients with a history of clinically significant allergies to VR040 formulation constituents (including lactose and opioids) and domperidone.
21. Patients with signs or symptoms suggestive of psychosis, dementia, "Parkinson-plus" syndromes or unstable systemic disease.
22. Patients with history of stroke, seizure or other neurological conditions.
23. Patients with dyskinesia rated 4 in Item 32 of UPDRS IV assessment at Screening(dyskinesia present ≥76% of a waking day).

Primary outcomes:
measure: The maximum UPDRS 3 improvement from pre-dose to post-dose
timeFrame: 90 minutes
Secondary outcomes:
measure: Time to improvement from 'off' to 'on'
timeFrame: 90 minutes
measure: The duration of 'on'
timeFrame: 90 minutes
measure: The proportion of patients converting to 'on' any time after treatment administration.
timeFrame: 90 minutes
Other outcomes:
measure: Safety variables
timeFrame: 90minutes
Locations:
city: Belgrade
country: Serbia
facility: Neurology Clinical Military Medical Academy, Crnotravska 17
city: Belgrade
country: Serbia
facility: Institute of Neurology Clinical Center Serbia Dr Subotica 6
city: Cardiff
country: United Kingdom
facility: University Hospital, Wales
city: Glasgow
country: United Kingdom
facility: Department of Neurology, Southern General Hospital
city: Liverpool
country: United Kingdom
facility: The Walton Centre
city: Llandudno
country: United Kingdom
facility: Llandudno Hospital
city: Newark
country: United Kingdom
facility: Newark Hospital
city: Oxford
country: United Kingdom
facility: Neurology Dept, Radcliffe Infirmary
city: Romford Essex
country: United Kingdom
facility: Essex Neurosciences, UnitOld Church Hospital, Essex
Study officials:
affiliation: South Glasgow NHS Hospitals
name: Donald Grosset, MD
role: PRINCIPAL_INVESTIGATOR
References: