Clinical trial NCT04515095: Water-only Fasting in the Treatment of Hypertension Patients
Official title: A Safety and Feasibility Study of Water-only Fasting and Refeeding for Treatment of Stage 1 and 2 Hypertensive Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Keywords: fasting
water-only fasting
whole-plant-food diet
Lead sponsor: TrueNorth Health Foundation
Sponsor class: OTHER
First posted: 2020-08-17
Enrollment: 30
Sex: ALL
Minimum age (years): 30
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This purpose of this study is to examine the safety and feasibility of water-only fasting to treat hypertensive patients.

Detailed description: This is a prospective, open label, single arm, intervention study to examine the safety and feasibility of water-only fasting to treat hypertensive patients. Additional aims include describing mean changes in resting blood pressure as well as markers of cardiovascular health and inflammation between baseline and end of fast, end of refeed, 6-weeks post departure, and 12-months after 6-weeks follow-up.

Eligibility criteria: Inclusion Criteria:

1. Any gender
2. 30-75 years old
3. Diagnosis of Stage 1 or 2 hypertension
4. Fasting plasma glucose \<126mg/dL and/or hemoglobin A1c \<7 percent
5. Elect and qualify for a water-only fast of at least 7 consecutive days
6. Provide informed consent
7. Internet and computer access
8. Able to go to LabCorp for 6-week follow-up visit
9. Willing/able to collect 24-hour urine sample prior to water-only fasting

Exclusion Criteria:

1. Systolic Blood Pressure/Diastolic Blood Pressure \>180/120 mmHg
2. Active malignancy
3. Active kidney disease (creatinine over 2.0)
4. Active inflammatory disorder including classic autoimmune connective tissue (Lupus, Sjogrens, ANCA), multiple sclerosis, and inflammatory bowel disorders (Ulcerative colitis, Crohn's)
5. Stroke, heart attack, deep vein thrombosis, atrial fibrillation, anticoagulant therapy, or pulmonary embolism within the last 12 months
6. Inability to discontinue medications or supplements
7. Abdominal metal implants
8. Inability to consume only plant food for at least 48 hours before fast begins.
9. Unable to lay still on the back for at least 10 min.

Primary outcomes:
measure: Determine number of treatment-associated of grade 1-4 adverse events as assessed by CTCAE v5.0
timeFrame: up to 10-60 days after baseline
Secondary outcomes:
measure: Examine the feasibility of using fasting and refeeding in the treatment of stage 1 and 2 hypertension based on change in systolic blood pressure (SBP)
timeFrame: Baseline, up to 10 to 40 days after baseline, up to 5 to 20 days after end of fast, 6-weeks after departure, 12-months after 6-weeks follow-up
measure: Examine the feasibility of using fasting and refeeding in the treatment of stage 1 and 2 hypertension based on treatment acceptability
timeFrame: Up to 7-40 days after baseline and 6-weeks after end of refeed
measure: Examine the feasibility of using fasting and refeeding in the treatment of stage 1 and 2 hypertension based on food acceptability
timeFrame: 6-weeks after end of refeed
measure: Examine the feasibility of using fasting and refeeding in the treatment of stage 1 and 2 hypertension based on dietary adhernece
timeFrame: 6-weeks after end of refeed
Other outcomes:
measure: Describe mean changes in resting blood pressure from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe mean changes in lipid profile from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe mean changes in fasting glucose and apolipoprotein B from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe mean changes in body mass index (BMI) from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe mean changes in insulin from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe mean changes in visceral adipose tissue from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed
measure: Describe mean changes in high sensitivity C-reactive protein (hsCRP) from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe mean changes in gamma-glutamyl-transferase (GGT) from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe mean changes in lipoprotein associated phospholipase A2 from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe mean changes in homocysteine from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe mean changes in aldosterone from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe mean changes in abdominal circumference from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe changes in renin activity from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe changes in sodium from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe changes in creatinine and total protein from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe changes in potassium from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe changes in albumin from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed, 12-months after 6-weeks follow-up
measure: Describe changes in 3-methyl-histidine from baseline
timeFrame: Baseline, up to 7-40 days after baseline, up to 3 to 20 days after end-of-fast, 6-weeks after end of refeed
Locations:
city: Santa Rosa
country: United States
facility: TrueNorth Health Center
state: California
Study officials:
affiliation: Director
name: Toshia R Myers, PhD
role: PRINCIPAL_INVESTIGATOR
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