Clinical trial NCT06169514: Health Systems and Policy Contexts of Medical Oxygen
Official title: Understanding the Health Systems and Policy Contexts of Medical Oxygen in Africa and Asia (MOXY-HSP)
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Hypoxemia
Morality
Pneumonia
Keywords: Health system
Oxygen
Oxygen systems
Oxygen access
Pulse oximetry
Lead sponsor: Murdoch Childrens Research Institute
Sponsor class: OTHER
Collaborators: name: University of Ibadan
name: University of Health Sciences, Lao People's Democratic Republic (PDR)
name: University of Health Sciences, Cambodia
name: Makerere University
name: Ministry of Health, Liberia
name: Ministry of Health, Rwanda
name: Karolinska Institutet
First posted: 2023-12-13
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study will be conducted in 6 of the 9 countries participating in the CHAI-led MOXY program (Uganda, Nigeria, Rwanda, Liberia, Lao PDR, Cambodia).

Brief summary: This is a mixed-methods program evaluation from a health systems and policy perspective, involving (i) stakeholder analysis, (ii) policy-implementation gap analysis, and (iii) comparative country case studies. This study aims to understand how national oxygen strategies achieve impact at national, and subnational level, across country contexts, at what cost.

The the investigators seek to:

1. Involve policymakers, implementers (including private sector), and medical oxygen users in identifying challenges and understanding potential solutions to medical oxygen access;
2. Generate new data on how medical oxygen systems work and can be improved from multiple perspectives;
3. Draw lessons on medical oxygen that can directly inform national and global practice and policy.

This study will be conducted in 6 of the 9 countries participating in the Clinton Health Access Initiative (CHAI) led Medical Oxygen Implementation (MOXY) program (Uganda, Nigeria, Rwanda, Liberia, Lao PDR, Cambodia).

Key informants will be selected representing government, non-governmental agencies, professional associations, private sector, and civil society. This study will be completed over 4 years, with timelines varying between country study sites.

Detailed description: The investigators will use a concurrent mixed-methods design, with an overarching comparative case study methodology. The investigators will adopt an iterative approach, using co-design to adapt the study methodology to the specific context of each country and annual learning team meetings with stakeholders to refine the final case study topics (sub-study 3) and methodology.

Three embedded sub-studies are planned:

Sub-study 1 (Stakeholder Analysis) aims to understand the policy environment for medical oxygen services across different country contexts. This will be informed by the MOXY baseline survey, which includes data on oxygen-related facility readiness and clinical practices across the MOXY program areas. Data sources will include stakeholder interviews with participants from different levels (national, provincial, local) and policy perspectives (government, implementing/advising partners, practitioners, beneficiaries). Results will inform sub-study 2 and MOXY program implementation.

Sub-study 2 (Policy-Implementation Gap Analysis) aims to critically analyse the gap between policy intentions and actual implementation. This will be informed by the baseline facility readiness and clinical practice data. Data sources will include a desk review of oxygen-related policies, stakeholder in-depth interviews, and program administrative data. Results will inform implementation of country oxygen strategies and feed into prioritization of focus areas for sub-study 3.

Sub-study 3 (Comparative Country Case Studies) aims to compare oxygen programs across countries, focusing on particular challenges or unique solutions identified in sub-study 1 and 2. Data sources will include repeated desk review of oxygen-related policies and program administrative data, follow-up stakeholder interviews, and triangulation with quantitative survey results on facility readiness and clinical practices.

This research will also draw on national stakeholder dialogues - both to review, refine, and validate preliminary findings of the study team and to draw out feasible solutions/alternatives for both policy and practice and oxygen eco-system. In year 1 the investigators will generate key evidence about how the current strategies and polices are being translated into action, identifying key opportunities for implementing partners to focus support. Over years 2 and 3, the investigators will learn how these activities have affected medical oxygen service coverage, drawing lessons across country contexts and across different implementation approaches.

Eligibility criteria: Key informants will be selected representing government, non-governmental agencies, professional associations, private sector, and civil society.

Primary outcomes:
measure: In-depth stakeholder interviews on national medical oxygen strategies
timeFrame: 4 years
Secondary outcomes:
Other outcomes:
Locations:
city: Phnom Penh
country: Cambodia
facility: Cambodia
city: Vientiane
country: Lao People's Democratic Republic
facility: Lao PDR
city: Monrovia
country: Liberia
facility: Liberia
city: Ibadan
country: Nigeria
facility: Nigeria
city: Kigali
country: Rwanda
facility: Rwanda
city: Kampala
country: Uganda
facility: Uganda
Study officials:
affiliation: Murdoch Childrens Research Institute
name: Hamish Graham, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Karolinska Institutet
name: Carina King, PhD
role: PRINCIPAL_INVESTIGATOR
References: