Clinical trial NCT00293410: Clofarabine and Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia, or Myeloproliferative Disorders
Official title: Phase I Dose-Escalation Trial of Clofarabine Followed by Escalating Doses of Fractionated Cyclophosphamide in Adults and Children With Relapsed or Refractory Acute Leukemias
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Chronic Myeloproliferative Disorders
Leukemia
Myelodysplastic/Myeloproliferative Diseases
Keywords: adult acute myeloid leukemia with 11q23 (MLL) abnormalities
adult acute myeloid leukemia with inv(16)(p13;q22)
adult acute myeloid leukemia with t(15;17)(q22;q12)
adult acute myeloid leukemia with t(16;16)(p13;q22)
adult acute myeloid leukemia with t(8;21)(q22;q22)
recurrent adult acute myeloid leukemia
recurrent childhood acute myeloid leukemia
secondary acute myeloid leukemia
myelodysplastic/myeloproliferative disease, unclassifiable
accelerated phase chronic myelogenous leukemia
chronic idiopathic myelofibrosis
chronic myelomonocytic leukemia
juvenile myelomonocytic leukemia
recurrent adult acute lymphoblastic leukemia
recurrent childhood acute lymphoblastic leukemia
acute undifferentiated leukemia
blastic phase chronic myelogenous leukemia
childhood chronic myelogenous leukemia
adult acute basophilic leukemia
adult acute eosinophilic leukemia
adult acute megakaryoblastic leukemia (M7)
adult acute minimally differentiated myeloid leukemia (M0)
adult acute monoblastic leukemia (M5a)
adult acute monocytic leukemia (M5b)
adult acute myeloblastic leukemia with maturation (M2)
adult acute myeloblastic leukemia without maturation (M1)
adult acute myelomonocytic leukemia (M4)
adult acute promyelocytic leukemia (M3)
adult erythroleukemia (M6a)
adult pure erythroid leukemia (M6b)
childhood acute basophilic leukemia
childhood acute monocytic leukemia (M5b)
childhood acute eosinophilic leukemia
childhood acute erythroleukemia (M6)
childhood acute megakaryocytic leukemia (M7)
childhood acute minimally differentiated myeloid leukemia (M0)
childhood acute myeloblastic leukemia with maturation (M2)
childhood acute myeloblastic leukemia without maturation (M1)
childhood acute myelomonocytic leukemia (M4)
childhood acute monoblastic leukemia (M5a)
childhood acute promyelocytic leukemia (M3)
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2006-02-17
Enrollment: 70
Sex: ALL
Minimum age (years): 2
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: RATIONALE: Drugs used in chemotherapy, such as clofarabine and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells.

PURPOSE: This phase I trial is studying the side effects and best dose of clofarabine and cyclophosphamide in treating patients with relapsed or refractory acute leukemia, chronic myelogenous leukemia, or myeloproliferative disorders.

Detailed description: OBJECTIVES:

Primary

* Determine the feasibility and tolerability of administering clofarabine and fractionated cyclophosphamide in patients with relapsed or refractory acute leukemia, chronic myelogenous leukemia, or high-risk myeloproliferative disorders
* Determine the maximum tolerated dose of clofarabine and fractionated cyclophosphamide in these patients.
* Determine the toxic effects of these drugs in these patients.

Secondary

* Obtain preliminary data of biologic and pharmacodynamic effects of this regimen on marrow and circulating leukemic blasts in these patients.

OUTLINE: This is a dose-escalation study. Patients are stratified according to age (adult vs child).

Patients receive cyclophosphamide IV over 2 hours on day 0. Patients then receive clofarabine IV over 2 hours and cyclophosphamide IV over 2 hours on days 1-3 and 8-10. Treatment with clofarabine and cyclophosphamide repeats every 28 days for at least 2 courses in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of clofarabine and cyclophosphamide until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. At least 10 patients are treated at the MTD.

After completion of study treatment, patients are followed periodically for 1 year.

PROJECTED ACCRUAL: A total of 70 patients will be accrued for this study.

Eligibility criteria: DISEASE CHARACTERISTICS:

* Histologically confirmed leukemia or myeloproliferative disorders, including 1 of the following:

  * Acute myeloid leukemia (AML) of any subtype

    * Treatment-related AML OR AML evolving from myeloproliferative disorders (MPD) or transformed from myelodysplastic syndrome
  * Acute lymphocytic leukemia
  * Acute progranulocytic leukemia

    * Must not be eligible for arsenic or retinoic acid therapy
  * Chronic myelogenous leukemia in accelerated phase or blast crisis
  * High-risk MPD, including any of the following:

    * Myelofibrosis
    * Chronic myelomonocytic leukemia with 5%-19% blasts
    * Relapsed or refractory juvenile myelomonocytic leukemia
* Relapsed and/or refractory disease with progressive disease since last therapy

  * No more than 3 prior induction regimens with cytotoxic agents for adults
  * Must be in second relapse for patients \< 21 years of age

PATIENT CHARACTERISTICS:

* ECOG performance status 0-2 (for adults) OR Lansky 50-100% (for pediatric patients)
* Bilirubin ≤ 1.5 mg/dL (may be elevated due to hemolysis in adult patients)
* AST and ALT ≤ 5 times upper limit of normal
* Creatinine ≤ 2.0 mg/dL (for adults)
* Normal renal function (for pediatric patients)
* Cardiac function normal as measured by MUGA scan or echocardiogram
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective barrier contraception during and for at least 6 months after completion of study treatment
* HIV negative
* No active graft-versus-host disease ≥ grade 2
* No active, uncontrolled infection
* No fever
* No unstable CT scans of the lungs, sinuses, or abdomen within the past 4 weeks
* No arrhythmias (other than atrial flutter or fibrillation) requiring medication
* No dyspnea at rest or with minimal exertion
* No uncontrolled congestive heart failure
* No myocardial infarction within the past 3 months
* No history of severe coronary artery disease
* No other significant concurrent disease, illness, or psychiatric disorder that would compromise patient safety or compliance or interfere with consent, study participation, follow up, or interpretation of study results

PRIOR CONCURRENT THERAPY:

* Must have recovered from all acute toxic effects from prior treatment
* More than 30 days since prior investigational cytotoxic agents
* At least 3 days since prior azacitidine, thalidomide, hydroxyurea, imatinib mesylate, or interferon
* At least 1 week since prior growth factors except epoetin alfa
* More than 3 weeks since any other prior anticancer therapy
* No concurrent chemotherapy, radiotherapy, or immunotherapy
* No other concurrent anticancer investigational or commercial agents
* No routine prophylactic use of a colony-stimulating factor (filgrastim \[G-CSF\] or sargramostim \[GM-CSF\])

  * Therapeutic use of colony-stimulating factors may be considered at the discretion of the investigator
* No prolonged use of corticosteroids to prevent or treat emesis or as a chemotherapeutic agent

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
state: Maryland
Study officials:
affiliation: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
name: Judith E. Karp, MD
role: STUDY_CHAIR
References:
citation: Karp JE, Ricklis RM, Balakrishnan K, Briel J, Greer J, Gore SD, Smith BD, McDevitt MA, Carraway H, Levis MJ, Gandhi V. A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias. Blood. 2007 Sep 15;110(6):1762-9. doi: 10.1182/blood-2007-03-081364. Epub 2007 Jun 11.