louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03419273: Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery
Official title: Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity, Morbid
Bariatric Surgery Candidate
Lead sponsor: University of Missouri-Columbia
Sponsor class: OTHER
First posted: 2018-02-01
Enrollment: 84
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All subject are already scheduled to have bariatric surgery at the University of Missouri-Columbia Department of Surgery.

Brief summary: A growing body of work done over the past few decades has established that adipose tissue as an active endocrine organ which secretes a wide range of metabolic and immunological factors collectively called "adipokines (1)." Importantly, these secreted factors enter into the circulation and have paracrine and autocrine actions, which profoundly impact systemic metabolism (e.g., insulin sensitivity). Additionally, in animals, loss of ovarian hormone production via ovariectomy (similar to menopause in humans) leads to increases in both in adipose tissue mass and in adipose tissue inflammation (2) making this tissue less healthy than that from premenopausal animals. To date, no studies have investigated the effect of menopause on abdominal fat in overweight individuals. Knowing if adipose tissue-specific changes occur with menopause may potentially lead to recommendations or therapeutics to improve women's health post menopause.

Detailed description: Subjects will just have to agree to having a small amount of adipose tissue being removed during the bariatric surgery. The investigators will also collect a blood sample at that time. There will be no other visits for the subject.

Eligibility criteria: Inclusion Criteria:

* Women who are premenopausal or who are postmenopausal and have been for at least one year.

Males will be recruited to age match female subjects. All subject are already scheduled to have bariatric surgery at the University of Missouri-Columbia Department of Surgery.

Exclusion Criteria:

* Women who are perimenopausal. Women who are on Hormone Replacement Therapy.

Primary outcomes:
measure: TNFa
timeFrame: measured in the one sample collected at surgery
measure: Il-6
timeFrame: measured in the one sample collected at surgery
measure: macrophage
timeFrame: measured in the one sample collected at surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Columbia
country: United States
facility: University of Missouri
state: Missouri
Study officials:
affiliation: University of Missouri-Columbia
name: Jill Kanaley, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Porter JW, Barnas JL, Welly R, Spencer N, Pitt J, Vieira-Potter VJ, Kanaley JA. Age, Sex, and Depot-Specific Differences in Adipose-Tissue Estrogen Receptors in Individuals with Obesity. Obesity (Silver Spring). 2020 Sep;28(9):1698-1707. doi: 10.1002/oby.22888. Epub 2020 Jul 31.
Clinical trial NCT05083273: Life Experience of People Aged 60 and Over Living with HIV
Official title: Life Experience of People Aged 60 and Over Living with HIV: Quantitative Sociological Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Virus-HIV
Keywords: VIH
Living with HIV
60 years old and over
Lead sponsor: Hôpital NOVO
Sponsor class: OTHER
First posted: 2021-10-19
Enrollment: 225
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: People aged 60 and over living with HIV

Brief summary: The purpose of this study is to Assess the impact of HIV on the life course of patients aged 60 and over.

Detailed description: COREVIH IDF Nord and CERMES3 conducted a first qualitative survey of 32 HIV patients aged 60 and over. The study, in the form of an individual interview, aimed to identify the difficulties that PLWHIV may encounter in their life course, to question their future and the impact that HIV could have.

From this study, a questionnaire was drawn up covering the points raised by the qualitative study. The questionnaire was designed by doctors of the four hospitals that participated in the first study and a sociologist from CERMES3.

After patient's oral agreement obtained, the study questionnaire "Sociological study PVHIV ≥ 60 years" will be given to the patient for completion.

Eligibility criteria: Inclusion Criteria :

People aged 60 and over living with HIV and view in consultation

Patient participation agreement obtained

Exclusion criteria :

People living with HIV less than 60 years old

Primary outcomes:
measure: Determine the impact of HIV in the life cours of people aged 60 and over and the questioning of the future.
timeFrame: Through study completion, an average of 6 month
Secondary outcomes:
Other outcomes:
Locations:
city: Clichy
country: France
facility: Hospital Beaujon, Clichy / Médecine Interne
city: Paris
country: France
facility: Université Paris Descartes - CERMES3
city: Paris
country: France
facility: Hôpital Bichat Claude-Bernard - Service de Maladies Infectieuses et Tropicales
city: Paris
country: France
facility: Hôpital Bichat Claude-Bernard -COREVIH Ile de France Nord
city: Pontoise
country: France
facility: Centre Hospitalier René Dubos
city: Saint-Denis
country: France
facility: Hospital Delafontaine, Saint-Denis / Maladie infectieuse
Study officials:
affiliation: Hôpital NOVO
name: Laurent Blum, Dr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04610073: The Effect of Interactive Multimedia Versus Illustrated Booklet on Behavior to Prevent Lower Back Pain in Working Nurses.
Official title: Comparison of the Effect of Interactive Multimedia Versus Illustrated Booklet on Behavior to Prevent Lower Back Pain in Working Nurses in the Hospitals Affiliated to Shiraz University of Medical Sciences.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Low Back Pain
Lead sponsor: Shiraz University of Medical Sciences
Sponsor class: OTHER
First posted: 2020-10-30
Enrollment: 153
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The present study was conducted to compare the effect of interactive multimedia and illustrated booklet methods on knowledge, attitude and improvement of behavior in preventing lower back pain amongst lower back pain amongst nurses.

Detailed description: In this single blind randomized controlled trial, 153 eligible nurses working in hospitals during 2019 were enrolled. The participants were randomly allocated into three parallel groups: interactive multimedia (n=55), illustrated booklet (n= 55), and the control (n= 43). The study samples were blinded to intervention and control groups. A researcher-made questionnaire was completed by the eligible subjects before, after, and four weeks after the intervention to assess their knowledge, attitude and behavior in preventing chronic lower back pain amongst working nurses.

Eligibility criteria: Inclusion Criteria:

* Minimum education level of bachelor's degree in nursing
* Employment in governmental hospitals
* Willing to participate in the study and complete the informed consent
* Minimum knowledge of working with computers

Exclusion Criteria:

* Congenital anomalies
* low back pain
* History of back surgery
* History of trauma to the back
* Pregnancy
* Severe osteoporosis

Primary outcomes:
measure: Behavior of the employed nurses in order to prevent low back pain
timeFrame: 5 weeks
Secondary outcomes:
measure: Knowledge of the employed nurses in order to prevent low back pain
timeFrame: 5 weeks
measure: Attitude of the employed nurses in order to prevent low back pain
timeFrame: 5 weeks
Other outcomes:
Locations:
city: Shiraz
country: Iran, Islamic Republic of
facility: Shiraz University of Medical Sciences
state: Fars
Study officials:
affiliation: associate Professor, Virtual school, Shiraz University of Medical Sciences, Shiraz, Iran.
name: Nahid zarifsanaiey, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01860573: Neurodevelopmental and Growth Outcomes of Early, Aggressive Protein Intake in Very Low Birthweight Infants
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prematurity
Keywords: Amino acids
Protein
Lead sponsor: Women and Infants Hospital of Rhode Island
Sponsor class: OTHER
First posted: 2013-05-22
Enrollment: 168
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether providing increased protein to premature infants in the first week of life allows for better growth during the hospital stay and improved developmental outcomes by age 2.


Eligibility criteria: Inclusion Criteria:

* birth weight 400 to 1250 grams
* 24 0/7 to 30 6/7 weeks gestational age

Exclusion Criteria:

* chromosomal, structural, metabolic, endocrine, or renal abnormalities that could affect growth
* infants \>18 hours of age
* infants in extremis who are unlikely to survive past 72 hours

Primary outcomes:
measure: Number of Participants With Weight<10th Percentile for Age
timeFrame: 36 weeks post-conceptual age
measure: Number of Participants With Length <10th Percentile for Age
timeFrame: 36 weeks post-conceptual age
measure: Number of Participants With Head Circumference <10th Percentile for Age
timeFrame: 36 weeks post-conceptual age
measure: Cognitive Development Score
timeFrame: 18-22 months corrected gestational age
Secondary outcomes:
measure: Serum Bicarbonate
timeFrame: Day of life 1, 2, 3, 5 and 7
measure: Serum Creatinine
timeFrame: Day of life 1, 2, 3, 5 and 7
measure: Serum Blood Urea Nitrogen
timeFrame: Day of life 1, 2, 3, 5 and 7
Other outcomes:
Locations:
city: Providence
country: United States
facility: Women & Infants Hospital of Rhode Island
state: Rhode Island
Study officials:
affiliation: Women and Infants Hospital of Rhode Island
name: Joseph M Bliss, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Poindexter BB, Langer JC, Dusick AM, Ehrenkranz RA; National Institute of Child Health and Human Development Neonatal Research Network. Early provision of parenteral amino acids in extremely low birth weight infants: relation to growth and neurodevelopmental outcome. J Pediatr. 2006 Mar;148(3):300-305. doi: 10.1016/j.jpeds.2005.10.038.
citation: Stephens BE, Walden RV, Gargus RA, Tucker R, McKinley L, Mance M, Nye J, Vohr BR. First-week protein and energy intakes are associated with 18-month developmental outcomes in extremely low birth weight infants. Pediatrics. 2009 May;123(5):1337-43. doi: 10.1542/peds.2008-0211.
citation: Thureen PJ, Melara D, Fennessey PV, Hay WW Jr. Effect of low versus high intravenous amino acid intake on very low birth weight infants in the early neonatal period. Pediatr Res. 2003 Jan;53(1):24-32. doi: 10.1203/00006450-200301000-00008.
citation: Amari S, Shahrook S, Namba F, Ota E, Mori R. Branched-chain amino acid supplementation for improving growth and development in term and preterm neonates. Cochrane Database Syst Rev. 2020 Oct 2;10(10):CD012273. doi: 10.1002/14651858.CD012273.pub2.
Clinical trial NCT02064673: Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy
Official title: Randomized Trial of Adjuvant Curcumin After Prostatectomy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Prostate Cancer
Keywords: prostate cancer
radical prostatectomy
Lead sponsor: University of Texas Southwestern Medical Center
Sponsor class: OTHER
First posted: 2014-02-17
Enrollment: 608
Sex: MALE
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a prospective study to determine if the adjuvant use of Curcumin improves recurrence-free survival.

Detailed description: This is a prospective study to determine if the adjuvant use of Curcumin improves recurrence-free survival in patients after radical prostatectomy compared to placebo

Eligibility criteria: Inclusion Criteria:

* Status post radical prostatectomy for histologically confirmed adenocarcinoma of the prostate
* pathologically confirmed T1-T3 disease
* no sign of lymph node or metastatic disease
* pT1-pT3pNxMx patients in whom standard NCCN or AUA guidelines would suggest are at low risk for pelvic lymph node or metastatic disease and who would not require confirmatory imaging for metastatic disease. This includes patients with Gleason 6 or 7(T2 disease) and PSA less than 20.
* Eastern Cooperative Oncology Group(ECOG) status 0-2
* adequate renal and liver function as well as bone marrow reserve (measured serum creatinine \<2mg/dl, bilirubin ≤ 1.5 mg/dl, ANC ≥ 1.5 x 10 (3) uL, platelets ≥ 50 x K/uLL, and hemoglobin ≥ 10 g/dL)
* 30-80 y/o at time of diagnosis with a life expectancy of \>= 3 yrs
* focally positive surgical margins are permitted
* no plan to receive adjuvant hormone or radiation therapy
* PSA at the time of enrollment must be undetectable
* life expectancy of 3 years

Exclusion Criteria:

* must not have exceeded 3 months from time of surgery to enrollment into study
* T3b or T4 or node positive disease
* macroscopic residual disease after surgery
* hormone therapy before surgery
* history of gallbladder problems or gallstones, or biliary obstruction, unless patient had cholecystectomy
* radiation therapy as primary treatment after surgery
* INR value greater than 1.5
* AST/ALT are equal or greater than 2 times the upper limit of normal
* antiplatelet or anticoagulant agents- patients taking 81mg of Aspirin will be allowed with close observation
* history of gastric or duodenal ulcers or untreated hyperacidity syndromes
* patients who are currently taking curcumin and are unwilling to stop or plan to take curcumin during the study

Primary outcomes:
measure: Serum prostate specific antigen
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Dallas
country: United States
facility: UT Southwestern Medical Center
state: Texas
Study officials:
affiliation: UT Southwestern Medical Center
name: Yair Lotan, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02500173: Analysis of Effects and Side Effects in Patients Undergoing Radiation Therapy
Official title: Analysis of Effects and Side Effects in Patients Undergoing Radiation Therapy - Quality Control Using Clinical Database
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Cancer
Keywords: radiotherapy
side effects
Lead sponsor: Kantonsspital Graubuenden
Sponsor class: OTHER
First posted: 2015-07-16
Enrollment: 1800
Sex: ALL
Minimum age (years): 20
Maximum age (years): 105
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing radiotherapy at the Kantonsspital Graubuenden

Brief summary: To collect and analyze effects and side effects in patients undergoing radiotherapy.

This study investigates how analysis of effects and side effects will influence outcome of patients. These retrospectively collected data allow to adapt and improve radiotherapy treatment regimens .

Detailed description: Effects and side effects in patients undergoing radiotherapy will be collected over the next five years (2015-2020). It is planned to include 600 to 650 new patients referred for radiotherapy per calender year. It is estimated that 3000 patients will be included at the end of the study after five years. Patient Information on diseae and treatment will be collected and analyzed. Common statistical algorithms will be performed for outcome analysis.

Eligibility criteria: Inclusion Criteria:

* Patients undergoing radiotherapy at the Kantonsspital Graubuenden

Exclusion Criteria:

* No radiotherapy at Kantonsspital Graubuenden
* Age: \< 20 years, \> 105 years

Primary outcomes:
measure: Side effects in patients undergoing radiotherapy (CTCAE v4.03)
timeFrame: 5 Years
Secondary outcomes:
Other outcomes:
Locations:
city: Chur
country: Switzerland
facility: Kantonsspital Graubuenden, Department of Radiaton Oncology
Study officials:
affiliation: Kantonsspital Winterthur, Department of Radiation Oncology
name: Daniel R Zwahlen, MD MBA
role: STUDY_CHAIR
References:
Clinical trial NCT00953173: HERO Study: Helping Evaluate Reduction in Obesity
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Lead sponsor: Apollo Endosurgery, Inc.
Sponsor class: INDUSTRY
First posted: 2009-08-06
Enrollment: 671
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients that have already made a decision, independent of the study, to proceed with LAP-BAND AP® implantation.

Brief summary: A prospective, international, multi-center study of clinical outcomes and estimated healthcare resource expenditures associated with the treatment of obesity using the LAP-BAND AP® Adjustable Gastric Banding System.


Eligibility criteria: Inclusion Criteria:

* Patient and investigator have made a decision, independent of the study, to proceed with LAP-BAND AP® implantation.
* Male or female aged ≥ 18 years.
* BMI ≥ 40 or a BMI ≥ 35 with one or more severe co-morbid conditions, or those who are 45.5 Kg / 100 lbs or more over their estimated ideal weight.

Exclusion Criteria:

* Prior bariatric surgery.
* Type I diabetes patients.
* Participating in another ongoing clinical study with concomitant diagnostic or therapeutic intervention that would reasonably be expected to alter patterns of care, use of medications or the outcomes under study.

Primary outcomes:
measure: %TBWL
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Everett
country: United States
state: Washington
city: Adelaide
country: Australia
state: South Australia
city: Jette
country: Belgium
city: Mississauga
country: Canada
state: Ontario
city: Naples
country: Italy
city: Birmingham
country: United Kingdom
Study officials:
References:
citation: Dixon JB, Eaton LL, Curry T, Lee PC. Health Outcomes and Explant Rates After Laparoscopic Adjustable Gastric Banding: A Phase 4, Multicenter Study over 5 Years. Obesity (Silver Spring). 2018 Jan;26(1):45-52. doi: 10.1002/oby.22050.
citation: Lao WL, Malone DC, Armstrong EP, Voellinger D, Somers S, Jin J, Dreyer N, Globe D. Effect of adjustable gastric banding on quality of life and weight loss in the Helping Evaluate Reduction in Obesity (HERO) registry study: 2 year analysis. Curr Med Res Opin. 2015 Aug;31(8):1451-60. doi: 10.1185/03007995.2015.1059802. Epub 2015 Jul 25.
citation: Ponce J, Taheri S, Lusco V, Cornell C, Ng-Mak DS, Shi R, Okerson T. Efficacy and safety of the adjustable gastric band - pooled interim analysis of the APEX and HERO studies at 48 weeks. Curr Med Res Opin. 2014 May;30(5):841-8. doi: 10.1185/03007995.2013.874992. Epub 2014 Jan 16.
Clinical trial NCT00808873: Socio-Educational Intervention for Rural Suicide Attempters
Official title: A Randomized Control Trial of a Socio-Educational Intervention for Rural Suicide Attempters in Tianjin Municipality and Shandong Province of China
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Suicide, Attempted
Keywords: attempted suicide
socio-educational intervention
follow up study
Lead sponsor: Beijing HuiLongGuan Hospital
Sponsor class: OTHER
Collaborators: name: Suicide Prevention International
name: Harvard University
name: University of Rochester
name: People's Hospital of Yuncheng County
name: Bureau of Health of Ji County
First posted: 2008-12-16
Enrollment: 450
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Compared to a treatment-as-usual group, providing brief mental health education to suicide attempters from rural parts of China at the time of their treatment in the emergency departments of general hospitals or local clinics and 6 home-visits (FOR those subjects WITH PHONES refuse home visits, THE INTERVIEWS WILL BE CONDUCTED OVER THE PHONE) over the twelve months after the attempt demonstrate continuing concern about the attempters ('befriending'), strengthen their social support networks and improve their problem-solving skills will significantly reduce their hopelessness, the severity of depressive symptoms, and level of suicidal ideation.


Eligibility criteria: Inclusion Criteria:

* suicide attempters
* must be 18 years or older
* no-zero intent to die

Exclusion Criteria:

* with communication difficulties
* living outside of the research sites

Primary outcomes:
measure: the severity of depressive symptoms
timeFrame: one year
Secondary outcomes:
measure: frequency and intensity of suicidal ideation
timeFrame: one year
Other outcomes:
Locations:
city: Yuncheng County
country: China
facility: People's Hospital of Yuncheng County
state: Shandong
Study officials:
affiliation: Beijing HuiLongGuan Hospital
name: Xianyun Li, Bachelor, Master of Medicine
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05963373: Pattern of Chronic Disease in Adult attendantsabove18years Old in New Vally Elkharga Family Medicine Clinic
Official title: Pattern of Chronic Diseases in Adults Above 18years Old
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Chronic Wasting Disease of Elk and Deer
Injury; Knee, Meniscus, Old Injury or Tear
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-07-27
Enrollment: 2
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Chronic diseased attendands

Brief summary: Globally one in three of all adult suffer from multible Chronic condition six in ten adult has achronic disease and four in ten adult have twoor more.It has been calculated that 58million death in2005 approximately 35million will be aresult of chronic disease health damaging behavior tobbaco use, poor physical activity and poor eating habbits are major contributors to the leading chronic diseases the leading chronic diseases in developed countries including arthritis, cardiovascular diseases,heart attacks,stroke,cancer, diabetes,breast\&colonic cancer , Aging increasing the risk of chronic diseases like dementia ,heart diseases,cancer these are the nation's leadingdrivers of illness,disability,death and health care costs.

Detailed description: In2008 more than1,2million people died from non communicable diseases accounting for nearly 60% of all death inthe region with wide several outbreaks of hospital acquired infection in the midlle east have occurredwith substantial morbidity and mortality.Egypt currently has the third highest prevelance of obesity inMena region after saudi arabia and Emirates similar to the Hispanic and native.American population central adiposity is particularly common among egyptienand is probably inherited the Egyptian national survey individual have central obesity.this be found strongly associated with increase risk of dm and cardiovascular diseases

Eligibility criteria: Inclusion Criteria:

* Attendands above18years

Exclusion Criteria:

* Attendants below18 years

Primary outcomes:
measure: morbidities
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Assiut University
name: Dalia Galal Mahran
role: PRINCIPAL_INVESTIGATOR
References: