Clinical trial NCT06663592: Efficacy of Adding Neural Mobilization Techniques in Patients with Cervical Radiculopathy
Official title: Effectiveness of Slider and Tensioner Neurodynamic Mobilization Techniques in Patients with Cervical Radiculopathy: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Cervical Radiculopathy
Neuromobılızatıon
Median Nerve
Electromyography
Nerve Conduction
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-10-29
Enrollment: 33
Sex: ALL
Minimum age (years): 30
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this randomized controlled trial is to investigate the effects of adding slider neural mobilization technique compared to tensioner neural mobilization technique to conventional physical therapy treatment on pain, function, cervical range of motion, hand grip strength, and electrophysiological parameters of the median nerve in patients with cervical radiculopathy.

Detailed description: Cervical radiculopathy (CR) is a condition where the nerve root of a spinal nerve is compressed or impaired, causing the pain and symptoms to spread beyond the neck, radiating to the shoulder, and upper limb. Cervical radiculopathy primarily results from an impingement and inflammation of a nerve root induced by a space-occupying lesion that reduces the size of the intervertebral foramen, as a degenerative lesion of the zygapophyseal joint or it is associated with a cervical disc derangement.

Patients presenting with CR complain of neck, periscapular, and radicular pain into the hand and arm. As well as neurologic symptoms such as sensory disturbances (paresthesia or numbness), muscle weakness with a reduced tendon reflexes in the affected nerve root or combination of these signs and symptoms .

The reported annual incidence of CR is 85 cases per 100,000 people in the population, while the prevalence is 3.5/1000 persons. The C7 nerve root is most frequently impacted, with more than half of all cases affecting this level.

Several studies utilized therapeutic exercises, manual therapy, other modalities cervical collar, cervical traction, postural education and different medications such as drugs and steroid injections in the conservative management for cervical radiculopathy in its different stages.

The neural mobilization (NM) is a manual therapy method that improves neural flexibility, lowers dynamic sensitivity of the nervous system, increases blood flow, and relief pain; for that, improved neural mobility and alleviated pain increases joint range of motion (ROM).

The neural mobilization techniques (NM) are delivered by two techniques, "sliding/gliding" and "tensioning". Tensioner technique generate tension from both ends of the nerve, while sliders involve gliding of the nerve relative to its surrounding structures by performing joint movements that elongate the nerve bed with minimal strain. In addition, sliders are usually less aggressive than tensioners and their use might be indicated at early disease stages.

Both techniques aid in preventing the formation of adhesions, to reduce endoneurial pressure reduce intraneural oedema increase nerve oxygenation, and decrease the ischemic pain.

Studies which used sliders and tensioners NM techniques in their clinical studies, showed significant changes in biomechanical factors such as patients' self-reports of pain, disability, ROM, endurance and muscle strength in management of musculoskeletal neck disorders with nerve-related symptoms.

Therefore, What are the possible effects of adding tensioner neural mobilization technique versus slider neural mobilization technique to conventional physical treatment in treating patients with cervical radiculopathy?

Eligibility criteria: Inclusion Criteria:

1. Current continuous or intermittent pain that has persisted for more than 3 months.
2. Motor, reflex, and/ or sensory changes in the upper limb.
3. Diminished deep tendon reflexes in the affected arm.
4. Paresthesia or numbness along the course of the nerve.
5. A positive Upper Limb Neural Tension 1 (ULNT) test for the median nerve, Spurlings test, compression test, cervical distraction test, less than 60° cervical rotation towards the symptomatic side, and Valsalva maneuver.
6. Unilateral affection in the upper limb.

Exclusion Criteria:

1. History of surgical procedures for pathologies giving rise to neck pain or CTS.
2. Clinical signs or symptoms of medical red flags; (infection, cancer, and cardiac involvement).
3. Patients with neck pain for signs and symptoms of serious pathology, upper cervical ligamentous insufficiency, unexplained cranial nerve dysfunction, and fracture.
4. Any systematic disease such as rheumatism and tuberculosis, cervical myelopathy, or multiple sclerosis.
5. Systemic disease is known to cause generalized peripheral neuropathy as diabetes mellitus.
6. Upper Motor neuron disease such as stroke and amyotrophic lateral sclerosis (ALS).
7. Complete loss of sensation along the involved nerve root.
8. Primary report of bilateral radiating arm pain.
9. Inability to tolerate the planned intervention.
10. Pregnant woman.
11. Thoracic outlet syndrome
12. Pronator teres syndrome

Primary outcomes:
measure: Visual Analogue Scale
timeFrame: At baseline, to the end of treatment at 4 weeks.
measure: The Arabic Version Of Neck Disability Index
timeFrame: At baseline, to the end of treatment at 4 weeks.
measure: Cervical Range of Motion
timeFrame: At baseline, to the end of treatment at 4 weeks.
measure: Hand Grip Strength
timeFrame: At baseline, to the end of treatment at 4 weeks.
measure: Nerve Conduction Study
timeFrame: At baseline, to the end of treatment at 4 weeks.
measure: F wave
timeFrame: At baseline, to the end of treatment at 4 weeks.
measure: H-Reflex
timeFrame: At baseline, to the end of treatment at 4 weeks.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
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