louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06101576: Readmission Following Prostatic Surgery
Official title: Readmission Following Endourological Prostatic Surgery for Benign Prostatic Obstruction: Review of 20 Years of Experience
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: BPH With Urinary Obstruction
Keywords: BPH
TURP
Laser prostatectomy
BNC
Holmium Laser
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2023-10-26
Enrollment: 4000
Sex: MALE
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: They will be the subdivided into four groups:

Group I: Patient who underwent transurethral incision of the prostate (TUIP) using electrical current or laser beam. Group II: Patient who underwent transurethral resection of the prostate (TURP) using momopolar or bipolar current. Group III: Patient who underwent vaporization of the prostate using plasma or laser energy (GreenLight PVP and Thulium vaporization of the prostate). Group IV: Patient who underwent anatomical endoscopic enucleation of the prostate (AEEP) using Holmium, Thulium or GreenLight laser or bipolar current.

Brief summary: This study will be conducted to estimate readmission rate and reasons for readmission after all modalities of endoscopic transurethral surgeries for treatment of BOO secondary to BPH in the last 20 years.

Detailed description: Computerized patient information system (PIS) of Urology and Nephrology Center (UNC) and database of prostate unit of UNC will be reviewed for all preoperative, intraoperative and post discharge data. All follow up visits will be traced for outcome measurement. Patients with no hospital follow up visit will be contacted by phone and interrogated about their LUTS control state, ongoing medication and history of secondary procedures.

Eligibility criteria: Inclusion Criteria:

Men who underwent transurethral prostatic surgery for BPH causing BOO at Urology and Nephrology Center, Mansoura University, Egypt from Jun. 2005 to Dec. 2024.

Exclusion Criteria:

1. Patients who underwent TUR tunnelling for prostatic adenocarcinoma.
2. LUTS secondary to neuropathic bladder.
3. Incidentally diagnosed prostate cancer after surgery

Primary outcomes:
measure: The need for post discharge hospital readmission.
timeFrame: 90 days
Secondary outcomes:
measure: Differences of readmission rates
timeFrame: 90 days
measure: Change in the causes of readmission over time.
timeFrame: 20 years
measure: Causes and predictors of readmission.
timeFrame: 90 days
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Urology and Nephrology Center
Study officials:
affiliation: Urology and Nephrology Center
name: Ahmed R EL-Nahas, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00238576: Lamotrigine in the Treatment of Bipolar Disorder in Women of Reproductive Age
Official title: Lamotrigine in the Treatment of Bipolar Disorder in Women of Reproductive Age
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bipolar Disorder
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2005-10-13
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Females age 18 through 45 with a diagnosis of bipolar, considering treatment with Lamotragine.

Brief summary: This project will expand current knowledge of reproductive biology in women with bipolar disorder as well as assessing the impact of lamotrigine use for the treatment of bipolar disorder on reproductive function. Specifically, this study examines mood over the menstrual cycle and ovulation for three consecutive menstrual cycles in women treated for bipolar I, II, or NOS (not otherwise specified) with lamotrigine. In addition, testosterone and lipid concentrations will be measured before the participant starts receiving lamotrigine, as well as six months after receiving lamotrigine.


Eligibility criteria: Inclusion Criteria::

* Female
* Ages 18 through 45
* Diagnosis of bipolar disorder (I, II, or NOS)
* Willing to sign the Human Subject Protection Consent Form prior to enrollment into the study
* Willing to use lamotrigine
* Never used lamotrigine prior to study entry Exclusion Criteria:- Unwilling or unable to comply with study requirements, e.g. complete forms, or attend scheduled evaluations
* Significant alcohol and/or substance abuse or dependence within the prior 6 months
* Used lamotrigine prior to study entry, or currently using lamotrigine at study entry

Primary outcomes:
measure: Changes in weight, glucose, lipid levels , insulin and testosterone concentrations over 6 months onmedication
timeFrame: 6 months
Secondary outcomes:
measure: Menstrual cycle length and presence or absence of ovulation
timeFrame: 6 months
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine
state: California
city: Stanford
country: United States
facility: Stanford University School of Medicine
state: California
Study officials:
affiliation: Stanford University
name: Dr Natalie Rasgon
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04983576: Risk Factors for Mechanical Failure After Spinal Fusion : an Observational Study
Official title: Risk Factors for Mechanical Failure After Spinal Fusion : an Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spinal Fusion
Surgery--Complications
Spine Disease
Lead sponsor: Istituto Ortopedico Rizzoli
Sponsor class: OTHER
First posted: 2021-07-30
Enrollment: 393
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients undergoind spine surgery with arthrodesis

Brief summary: The aim of this of study is to identify the incidence of mechanical failures after spinal fusion within one year of surgery and to assess the related risk factors.


Eligibility criteria: Inclusion Criteria:

* All patients undergoing spine fusion and followed up for clinical checks in the year following the surgery .

Exclusion Criteria:

* patients undergoing spine surgery without the application of instrumentation

Primary outcomes:
measure: incidence of mechanical failure
timeFrame: up to 1 year from the surgery
Secondary outcomes:
measure: deambulation performed during hospitalization
timeFrame: up to the first day(up to 1 day) for ambulation from the surgery
Other outcomes:
Locations:
city: Bologna
country: Italy
facility: Vincenzo Peccerillo
state: BO
Study officials:
References:
Clinical trial NCT02088476: Candidemia in a Pediatric Center and Importance of Central Venous Catheter Removal
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Candidemia
Keywords: candidemia
children
mortality
risk factors
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2014-03-17
Enrollment: 248
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Children diagnosed with candidemia were included in our hospital between Jan 2004 and Dec 2012.

Brief summary: Candidemia has emerged as an important cause of hospital-associated blood-stream infection in children. The purpose of this study was to identify differences in distribution of candida species, risk factors, treatment, and clinical outcome of candidemia in children. This study in children ≤18 years with blood culture proven candidemia identified between 2004 and 2012. Analyses included the determination of causative candida species, resistance to antifungals and clinical outcome, as well as the identification of potential risk factors associated with candidemia.


Eligibility criteria: Inclusion Criteria:

* Presence of growth of any candida species in at least one blood culture

Exclusion Criteria:

* Febrile neutropenic patients who were using empirical antifungal agents

Primary outcomes:
measure: Risk factors of candidemia
timeFrame: up to 3 months
Secondary outcomes:
measure: Prognosis according to candida species
timeFrame: up to 3 months
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University Faculty of Medicine
Study officials:
References:
citation: Karadag-Oncel E, Kara A, Ozsurekci Y, Arikan-Akdagli S, Cengiz AB, Ceyhan M, Gur D, Celik M, Ozkaya-Parlakay A. Candidaemia in a paediatric centre and importance of central venous catheter removal. Mycoses. 2015 Mar;58(3):140-8. doi: 10.1111/myc.12288. Epub 2015 Feb 10.
Clinical trial NCT04681976: Telematic Dance Intervention on Quality of Life of Older
Official title: Effectiveness of a Telematic Dance Intervention on the Quality of Life of Older People: Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging Well
Keywords: older; dance; muscle strenght; quality of life
Lead sponsor: University of Valencia
Sponsor class: OTHER
First posted: 2020-12-23
Enrollment: 60
Sex: ALL
Minimum age (years): 60
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this study is to analyse the effectiveness of a telematic dance intervention on the quality of life of older people.

This project is a controlled, randomized clinical trial. 54 people (Intervention Group, n=27; Control Group, n=27) between the ages of 60-80 will participate in the study.

Intervention Group participants will perform a 3-month telematic dance program based on choreographic work. The participants shall be measured 3 times, at baseline, post-intervention, and at 6-month post-intervention follow-up. Aside from the quality of life, variables of balance, risk of falling, number of falls, level of physical activity, mood, functionality, comorbidity, and quadriceps strength will also be measured.


Eligibility criteria: Inclusion Criteria:

* Aged 60-80.
* Owning a device that can connect to internet to visualize videos and do videocalls, in case a session to resolve doubts is necessary.

Exclusion Criteria:

* Subjects with degenerative or cognitive pathologies
* Subjects with severe visual deficiencies.
* Subjects with any acute pain.
* Subjects with inability to stand.
* Subjects with any medical contraindication to exercise (cardiovascular risk factors).
* Subjects incapable of managing telematic devices to follow the sessions.
* Subjects who refuse to sign the informed consent.

Primary outcomes:
measure: Changes in quality of Life
timeFrame: 0-3 months
Secondary outcomes:
measure: Adherence
timeFrame: 0-3 months
measure: Body composition
timeFrame: 0-3 months
measure: Balance
timeFrame: 0-3 months
measure: Fear of falling
timeFrame: 0-3 months
measure: Level of physical activity
timeFrame: 0-3-6 months
measure: Mood
timeFrame: 0-3-6 months
measure: Functionality
timeFrame: 0-3 months
measure: Knee extension isometric strength
timeFrame: 0-3 months
Other outcomes:
Locations:
city: Valencia
country: Spain
facility: University of Valencia - Faculty of Physiotherapy
Study officials:
affiliation: Universitat de Valencia
name: Francisco Martínez-Arnau, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04107376: Inspection of the Colon Using a Retrograde Viewing Device for Detection of Colorectal Polyps
Official title: Inspection of the Colon Using a Retrograde Viewing Device for Detection of Colorectal Polyps
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Adenoma
Polyps
Keywords: retroviewing
endoscopy
adenoma detection
polyp detection
Lead sponsor: University of Erlangen-Nürnberg Medical School
Sponsor class: OTHER
First posted: 2019-09-27
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: During standard colonoscopy a substantial number of colorectal polyps may be missed. Previous studies have found a 12-28% of miss rate for all polyps, a 31% for hyperplastic polyps and 6-27% for adenomas. In this study it is tested whether a retro viewing endoscope can detect more colorectal polyps in comparisson to standard forward viewing endoscopy. Further, ppolyps detected, mean adenomas per Patient and withdrawal time are recorded.


Eligibility criteria: Inclusion Criteria:

* screening colonoscopy
* 18 years of age

Exclusion Criteria:

* inflammatory bowel disease
* inadequate bowel preparation

Primary outcomes:
measure: Adenoma detection rate
timeFrame: 8 months
Secondary outcomes:
measure: Polyp detection rate
timeFrame: 8 months
measure: Mean number of adenomas per patient
timeFrame: 8 months
measure: Withdrawal time
timeFrame: 8 months
Other outcomes:
Locations:
city: Erlangen
country: Germany
facility: University Hospital Erlangen
Study officials:
References:
Clinical trial NCT04219176: Spectral Optical Coherence Tomography Findings in Patients With Ocular Toxoplasmosis
Official title: Spectral Optical Coherence Tomography Findings in Patients With Ocular Toxoplasmosis : a Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ocular Toxoplasmosis
Keywords: Spectral optical coherence tomography
Ocular toxoplasmosis
Uveitis
Lead sponsor: Université de Sousse
Sponsor class: OTHER
First posted: 2020-01-06
Enrollment: 9
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Nine eyes of nine patients consecutively diagnosed with ocular toxoplasmosis were included in this retrospective study. The patients were examined at ophthalmology service of Farhat Hached Hospital in Sousse Tunisia between January 2002 and December 2017

Brief summary: Ocular toxoplasmosis is the most common cause of infectious uveitis worldwide. The diagnosis of ocular toxoplasmosis is primarily clinical when it is a typical presentation .With an atypical presentation in the fundus, parasitological diagnosis is a decisive contribution, as well as multimodal imaging. We investigate on vitreal, retinal, and choroidal morphologic changes in active and scarred toxoplasmosis lesions using swept source optical coherence tomography.

Detailed description: A retrospective analysis of patients diagnosed with ocular toxoplasmosis was conducted. The patients were examined at ophthalmology service of Farhat Hached Hospital in Sousse Tunisia between January 2002 and December 2017. Complete ophthalmologic examination and OCT were done at the initial visit and during follow-up.

Eligibility criteria: Inclusion Criteria:

* all patients hospitalized for ocular toxoplasmosis.

Exclusion Criteria:

* patients with non active ocular toxoplasmosis

Primary outcomes:
measure: number of prticipant affected with ocular toxoplasmosis
timeFrame: up to one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05833776: Value of IPACK Block (Interspace Between the Popliteal Artery and Capsule of Knee) With Spinal Anesthesia Versus Fentanyl Based Spinal Anesthesia for Knee Arthroscopic Meniscectomy
Official title: Value of IPACK Block (Interspace Between the Popliteal Artery and Capsule of Knee) With Spinal Anesthesia Versus Fentanyl Based Spinal Anesthesia on Postoperative Analgesia for Knee Arthroscopic Meniscectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post Operative Pain
Keywords: IPACK Block, spinal anesthesia, Knee arthroscopy.
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2023-04-27
Enrollment: 60
Sex: ALL
Minimum age (years): 25
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Postoperative analgesia is provided by local anesthesia combined with intrathecal narcotics. In addition, for the first 24 hours, this combination has a parenteral opioid sparing effect. However, despite its benefits, this method has been associated to an increased incidence of urine retention, nausea, and vomiting, as well as pruritus. A new localized analgesic approach called as IPACK (infiltration between the knee capsule and the popliteal artery) has been employed in practice.

Detailed description: The goal of this study was to compare fentanyl based spinal anesthesia to IPACK Block-based spinal anesthesia during knee arthroscopy.

Patients and Methods: The study enrolled sixty patients with ASA (I-II) ranging in age from 25 to 60 years old after receiving ethical committee permission and written informed consent from patients. They were divided into two groups: group F (30 patients) received spinal anesthesia using hyperbaric bupivacaine 0.5% (3ml) with fentanyl (25ug) and group I (30 patients) received spinal anesthesia using hyperbaric bupivacaine 0.5% (3ml) with IPACK Block using plain bupivacaine 0.5% (15ml). Results: In the first 4 hours postoperatively, there were no variations in VAS scores between the two groups; however, following 4 hours and over the next 12 hours, Group I, VAS scores were lower. The amount of morphine used overall was lower in Group I, which took longer than Group F to reach initial rescue analgesia. The level of patient satisfaction 48 hours after surgery was higher in group I than in group F.

Eligibility criteria: Inclusion Criteria:

age from 25 to 60 years old, with ASA physical status I-III undergoing for knee arthroscopy

Exclusion Criteria:

Patient refusal, neuromuscular diseases, allergies to local anesthetics, and contraindications to spinal anesthesia such as coagulopathy and severe mitral stenosis

Primary outcomes:
measure: post-operative analgesia
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Mohamed
Study officials:
References:
Clinical trial NCT02343276: Randomized Clinical Trial Comparing Transradial Catheterization With or Without Spasmolytic Drugs
Official title: Randomized Clinical Trial Comparing Transradial Catheterization With or Without Spasmolytic Drugs.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Cardiac Catheterisation
Keywords: Radial Spasm
Lead sponsor: Instituto de Cardiologia de Santa Catarina
Sponsor class: OTHER
First posted: 2015-01-21
Enrollment: 328
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Single-center study, randomized, double-blind, placebo controlled, with patients undergoing diagnostic or therapeutic catheterization via the transradial approach. Patients will be randomized into two groups: one group will receive the vasodilator nitroglycerin during the procedure (intervention group), and a second group will receive saline 0.9% in the same volume and time during the procedure (control group).

Will be evaluated: incidence of spasms of the radial artery, ability to perform the procedure without the need to change the access site, pain presented by the patient, time and total radiation of the procedure.


Eligibility criteria: Inclusion Criteria:

* Indication for cardiac catheterization
* Suitable candidates for transradial approach

Exclusion Criteria:

* AMI
* Intubated patients
* Complications during procedure (cardiac arrest, pulmonary edema, cardiogenic shock, stroke)
* Prior inclusion in this trial

Primary outcomes:
measure: Pain Assessment Using Visual Analogue Scale
timeFrame: Five minutes after sheath removal
Secondary outcomes:
measure: Procedure Duration
timeFrame: Immediate
measure: Radiation Exposure
timeFrame: Immediate
Other outcomes:
Locations:
city: São Jose
country: Brazil
facility: Instituto de Cardiologia de Santa Catarina
state: SC
Study officials:
affiliation: Instituto de Cardiologia de Santa Catarina
name: Roberto L da Silva, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05601076: Small-diameter Closed Thoracic Drainage Tube Fixation Method
Official title: Design and Application of Small-diameter Closed Thoracic Drainage Tube Fixation Following Lung Wedge Resection: a Randomised Prospective Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pulmonary Wedge Resection
Lead sponsor: Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Sponsor class: OTHER
First posted: 2022-11-01
Enrollment: 139
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objective: To explore the design feasibility and application effect of triple-buffer-system-fixed small-diameter (18 F) thoracic closed drainage tubes following lung wedge resection. Methods: A total of 136 patients with indwelling thoracic drainage tubes following pulmonary wedge resection were recruited, with 70 patients allocated to the control group and 66 to the experimental group. The drainage tube in the experimental group was fixed with the triple-buffer system, while that in the control group was fixed using the conventional lifting platform method. The incidence of unplanned extubation, the indwelling time of the drainage tube and the time and material costs, as well as information regarding any subcutaneous emphysema and skin tension blisters, were recorded following the operation. The pain and degree of comfort were assessed using a chi-square test and a rank sum t-test to compare the differences between the two groups.


Eligibility criteria: Inclusion Criteria:

* Single-port thoracoscopic wedge resection of the lung was performed for the first time
* No air leak in the lung tissue was detected
* The patient could communicate and cooperate normally.
* No local skin allergy or scar could be observed.

Exclusion Criteria:

* Patients with wide adhesion of the whole thoracic mucosa.
* Patients with postoperative or intraoperative bleeding.
* Patients with severe postoperative hypoproteinaemia or chylothorax with massive pleural effusion.
* Patients diagnosed with emphysema.

Primary outcomes:
measure: The extubation standard
timeFrame: 2 hours
measure: the pain numerical rating scale
timeFrame: 2 hours
measure: the Kolcaba comfort scalea(four-point scale)
timeFrame: 2 hours
measure: The adverse reactions
timeFrame: 2 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Taizhou
country: China
facility: Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
state: Zhejiang
Study officials:
affiliation: Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
name: Caifang Yang, Dr.
role: STUDY_DIRECTOR
References: