Clinical trial NCT03868423: Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers
Official title: Phase II Study of Brigatinib for Advanced Solid Cancers Harboring Genomic Alterations in ALK (Excluding Lung) and ROS1 Oncogenes
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
Conditions: Advanced Malignant Neoplasm
ALK Fusion Protein Expression
ALK Gene Amplification
ALK Gene Mutation
Locally Advanced Malignant Solid Neoplasm
Metastatic Malignant Neoplasm in the Brain
Metastatic Malignant Neoplasm in the Central Nervous System
Metastatic Malignant Solid Neoplasm
ROS1 Fusion Positive
ROS1 Gene Amplification
ROS1 Gene Mutation
Lead sponsor: Ohio State University Comprehensive Cancer Center
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2019-03-11
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This phase II trial studies how well brigatinib works in treating patients with ALK and ROS1 gene alterations and solid cancers that have spread to nearby tissue and lymph nodes or other places in the body. Brigatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Detailed description: PRIMARY OBJECTIVES:

I. To evaluate the overall response rate (ORR) of brigatinib in patients with advanced solid tumors harboring genomic alterations in ALK (excluding lung) and ROS1 (all solid tumors).

SECONDARY OBJECTIVES:

I. To assess the safety and tolerability of brigatinib in patients with advanced solid tumors harboring genomic alterations in ALK (excluding lung) and ROS1 (all solid tumors).

II. To assess progression free survival (PFS) and overall survival (OS) in patients with advanced ALK or ROS1 mutated solid tumors treated with brigatinib.

III. To assess sensitivity and durability of response to brigatinib in different solid tumor types.

IV. To assess the role of intertumoral and intratumoral heterogeneity in the development of resistance to brigatinib.

V. To identify candidate genomic (including circulating tumor deoxyribonucleic acid \[DNA\]) and proteomic biomarkers of tumor sensitivity and resistance to brigatinib using high-throughput approaches (exome, transcriptome, reverse phase protein array \[RPPA\]).

TERTIARY OBJECTIVES:

I. Correlation of brigatinib exposure with efficacy and safety. II. Correlation of tumor and plasma biomarkers with brigatinib efficacy and safety.

OUTLINE:

Patients receive brigatinib orally (PO) once daily (QD) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 52 weeks.

Eligibility criteria: Inclusion Criteria:

* Patients with histologically or cytologically confirmed diagnosis of locally advanced or metastatic solid tumors
* Patients must have activating genomic alterations in ALK or ROS1 (mutations, fusions or amplifications) by any validated Clinical Laboratory Improvement Act (CLIA)-certified molecular testing (fluorescence in situ hybridization \[FISH\], polymerase chain reaction \[PCR\] or next-generation sequencing \[NGS\] data are acceptable); CLIA validated results from other institutions and commercial diagnostic labs (e.g. Foundation Medicine) are also acceptable
* Patients with progressive disease on any previous therapy including crizotinib and other ALK tyrosine kinase inhibitors (TKIs), chemotherapy or immunotherapy
* Patients with locally advanced or metastatic solid tumors who have received no previous therapy of any kind (i.e. first-line therapy) are eligible
* Patients with brain metastases or metastases elsewhere within the central nervous system (CNS) are eligible for study; patients must be neurologically stable and asymptomatic
* Patients with tumor suitable for biopsy (as assessed by trained specialists in interventional radiology) and medically fit to undergo a biopsy or surgical procedure will have mandatory pre-treatment tumor biopsy or sampling; however, if patients do not have a tumor suitable for biopsy but have another tissue (preferably progressive metastatic site) available for molecular evaluation this will be acceptable
* Patients with solid tumors must have at least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1; Note: previously irradiated lesions may not be used for target lesions; unless there is unambiguous radiological progression after radiotherapy; brain lesions may not be used as target lesions if they were: 1) previously treated with whole brain radiation therapy (WBRT) within 3 months, or 2) previously treated by stereotactic radiosurgery (SRS) or surgical resection
* Eastern Cooperative Oncology Group (ECOG) performance status =\< 2
* Life expectancy of greater than 3 months
* Patients with multiple malignancies remain eligible
* Patients with an inherited cancer syndrome or a medical/family history suggestive of an inherited cancer syndrome remain eligible
* Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and through 4 months after the end of treatment; for women of childbearing potential, a negative pregnancy test must be documented prior to registration
* Absolute neutrophil count \>= 1,500/mcL
* Hemoglobin \>= 10 g/dL
* Platelet count \>= 75,000/mcL
* Total bilirubin =\< 1.5 x upper limit of normal (ULN), unless due to Gilbert?s syndrome (\< 5 if metastatic involvement of the liver)
* Serum lipase =\< 1.5 x ULN
* Serum amylase =\< 1.5 x ULN
* Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/ alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x institutional ULN
* Left ventricular ejection fraction (LVEF) \>= 50% by echocardiogram or multi-gated acquisition (MUGA)
* Normal QT interval on screening electrocardiogram (ECG), defined as QT interval corrected of =\< 450 ms in males or =\< 470 ms in females
* Serum creatinine =\< 1.5 mg/dL OR calculated creatinine clearance (Cockroft-Gault formula) \>= 60 mL/min OR 24-hour urine creatinine clearance \>= 60 mL/min
* Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

* Patients with hematological malignancies
* Patients with ALK positive (+) lung cancer
* Major surgery (e.g. thoracic, abdominal, vascular, neurosurgery) within 30 days prior to registration on study
* Pregnant women or mothers who are breastfeeding
* Patients who are incarcerated
* Patients who have a history or the presence at baseline of pulmonary interstitial disease or drug-related pneumonitis, or radiation pneumonitis
* Patients who have a known history of human immunodeficiency virus (HIV); testing not required in the absence of history
* Patients with history of clinically significant bleeding disorder or history of active significant gastrointestinal (GI) bleeding within 3 months of first dose of brigatinib
* Patients who have malabsorption syndrome or other GI illness or condition that could affect oral absorption of the study drug
* History of allergic or suspected hypersensitivity reactions attributed to compounds of similar chemical or biologic composition to brigatinib
* Patients with history of clinically significant atrial arrhythmias (requiring any anti-arrhythmic therapy or as determined by the treating physician) or any history of ventricular arrhythmias
* Patients who have significant, uncontrolled or active cardiovascular disease, including but not restricted to the following:

  * Myocardial infarction (MI) within 6 months prior to first dose of brigatinib
  * Unstable angina (UA) within 6 months prior to first use
  * Decompensated congestive heart failure within 6 months prior to first dose
  * Cerebrovascular accident (CVA) or transient ischemic attack (TIA) within 6 months prior to first dose
* Clinically significant, uncontrolled intercurrent illness including, but not limited to:

  * Symptomatic or active infection requiring intravenous (IV) antibiotics
  * Psychiatric illness and/or social situations that would limit compliance with completion of study requirements
* Patients on medications known to be associated with torsades de pointes
* Patients who have uncontrolled hypertension; patients with hypertension should be under treatment on study entry to control blood pressure
* Patients who have received cytotoxic chemotherapy, investigational agents, or radiation within 14 days, except stereotactic radiosurgery (SRS) or stereotactic body radiosurgery
* Patients who have received monoclonal antibodies or had major surgery within 30 days of the first dose of brigatinib
* Patients who have not recovered (=\< Common Terminology Criteria for Adverse Events \[CTCAE\] grade 1) from adverse events (with the exception of alopecia) due to agents administered more than 4 weeks earlier
* Patients with symptomatic CNS metastases that are neurologically unstable or require increasing dose of corticosteroids
* Patients with current spinal cord compression

Primary outcomes:
measure: Overall response rate assessed per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1
timeFrame: Up to 52 weeks
Secondary outcomes:
measure: Confirmed objective response rate (ORR)
timeFrame: Up to 52 weeks
measure: Time to response
timeFrame: Up to 52 weeks
measure: Duration of response
timeFrame: From the time measurement criteria are met for complete response or partial response (whichever is first recorded) until the first date that recurrent or progressive disease is objectively documented, assessed up to 52 weeks
measure: Time on treatment
timeFrame: Up to 52 weeks
measure: Disease control rate
timeFrame: Up to 52 weeks
measure: Incidence of adverse events assessed by National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0
timeFrame: Up to 52 weeks
measure: Overall survival
timeFrame: From treatment initiation to death due to any cause, assessed up to 52 weeks
measure: Progression-free survival
timeFrame: From the date of study registration to the date of event (ie, death and/or disease progression) or the date of last follow-up if no event has occurred, up to 52 weeks
measure: Clinical benefit rate
timeFrame: 6 months
measure: Rate of participation of those screened and identified with the eligible genetic alterations
timeFrame: Up to 52 weeks
measure: Rate of enrollment of those screened and identified with the eligible genetic alterations
timeFrame: Up to 52 weeks
Other outcomes:
measure: Brigatinib exposure
timeFrame: Up to 52 weeks
measure: Correlative gene and protein markers
timeFrame: Up to 52 weeks
Locations:
city: Columbus
country: United States
facility: Ohio State University Comprehensive Cancer Center
state: Ohio
Study officials:
affiliation: Ohio State University Comprehensive Cancer Center
name: Sameek Roychowdhury, MD
role: PRINCIPAL_INVESTIGATOR
References: