louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01319292: To Investigate the Prevalence of Children Asthma in China
Official title: To Investigate the Prevalence of Children Asthma in China and Compare With That of the Last 20 Years
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Asthma
Lead sponsor: Capital Institute of Pediatrics, China
Sponsor class: OTHER
Collaborators: name: Merck Sharp & Dohme LLC
First posted: 2011-03-21
Enrollment: 20000
Sex: ALL
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: children age from 0 to 14 years in big cities in China

Brief summary: Asthma is the most common chronic respiratory disease in children and has much effect on their life and study, which leads to huge economic burden and pressure to the whole families. Some children will develop into adult patients so that asthma can be the life-long vigorous trouble. In recent years, the prevalence rate of children asthma is increasingly going up worldwide. The prevalence rate in last 12 months reported in USA, United Kingdom, Australia, New Zealand was between 12% to 30%.

Center for Asthma Prevention and Education of Capital Institute of Pediatrics investigated the national asthma prevalence in 900 thousands children in 27 provinces and cities, which average rate was 0.11% to 2.03% in 1990. In 2000, we investigated it again in 31 provinces(43 cities) and the average national children asthma prevalence rate was 1.97%(0.25% to 4.63%) which was much higher than that in 1990.

Detailed description: 1. Objectives

   1. To investigate the national children(0-14 years old)asthma prevalence;
   2. To compare the prevalence rate between that in 1990 and 2000;
   3. To analyse the asthma manifestations including the ages, seasons, causes, trigger and hereditary factors and their impact on the asthma patients, families and society;
   4. To identify the risk factors by questionnaires in case-control research.
2. Study Design / Clinical Plan

   1. The screening stage: to distinguish suspected asthma from the children age from 0 to 14 years old.
   2. To obtain identified asthma from the suspected asthma.
   3. To evaluate the prevalence and severe degree of 0 to 14-year-old children asthma and gain the main risk factors by case-control research.

Eligibility criteria: Inclusion Criteria:

* children age from 0 to 14 years

Exclusion Criteria:

* none

Primary outcomes:
measure: prevalence of asthma
timeFrame: Apr 2013
Secondary outcomes:
measure: prevalence of allergic rhinitis
timeFrame: Apr 2013
Other outcomes:
Locations:
Study officials:
affiliation: Capital Institute of Pediatrics, China
name: YuZhi Chen, professor
role: STUDY_CHAIR
References:
Clinical trial NCT05237492: The Influence of Tramadol on Platelet Function
Official title: The Influence of Tramadol on Platelet Function
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Drug Toxicity
Platelet Dysfunction
Clotting Disorder
Lead sponsor: Medical University of Graz
Sponsor class: OTHER
First posted: 2022-02-14
Enrollment: 33
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The aim of this ex-vivo study is to quantify the effect of tramadol on platelet aggregation.

Detailed description: The aim of this study is to quantify the effect of tramadol on platelet aggregation. To this end, the effect of tramadol on platelet function will be demonstrated in an ex-vivo study using optical aggregometry (LTA) on whole blood of 15 patients.

The main objective variable is to use platelet function assays (LTA) as well as thrombelastography (TEG) to determine this effect on platelet function.

The null hypothesis of this study is that tramadol does not affect platelet aggregation in healthy patients.

In addition, two further questions will be addressed:

* using a titration series, to attempt to plot a dose/response curve of the effect of tramadol on platelet function.
* tramadol is often administered together with other drugs such as NSAIDs (ibuprofen), novalgin, SSRIs or other opioids such as morphine or in the surgical setting fentanyl and remifentanil. A series of studies will be conducted to determine whether these combinations alter the effect of tramadol on platelet function.

Eligibility criteria: Inclusion Criteria:

* 18y and older, healthy volunteers

Exclusion Criteria:

* Age \< 18 years
* Pregnant women
* History of addiction (especially opiate abuse)
* Pre-existing general addictive disease
* Ongoing pain therapy with opiates
* Taking antidepressants (SNRI, SSRI)
* History of thrombocytopathy or coagulation disorders
* Therapy with drugs that influence thrombocyte function (ASS, clopidogrel, prasugrel, ticagrelor or similar)
* Known intolerance to opiates

Primary outcomes:
measure: Procoagulant effect on platelet function demonstrated by optical aggregometry (LTA) on whole blood.
timeFrame: up to 4 hours
Secondary outcomes:
measure: Dose/ Response - Curve
timeFrame: up to 4 hours
measure: Combinations with Tramadol and other drugs and their procoagulant effect on platelet function demonstrated by optical aggregometry (LTA) on whole blood.
timeFrame: up to 4 hours
Other outcomes:
Locations:
city: Graz
country: Austria
facility: Dept. of Anaesthesiology and Intensive Care Medicine, Medical University of Graz
Study officials:
affiliation: Medical University of Graz
name: Philipp Zoidl, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06129292: The Effect of Emotional Freedom Technique on Breastfeeding
Official title: The Effect of Emotional Freedom Technique on Breastfeeding in Women Experiencing Maternity Blues
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Breastfeeding
Keywords: Emotional Freedom Techniques
Breastfeeding
Maternity blues
Midwifery
Lead sponsor: Karabuk University
Sponsor class: OTHER
First posted: 2023-11-13
Enrollment: 64
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study was planned to determine the effect of the emotional liberation technique on breastfeeding in women experiencing motherhood sadness.

Detailed description: Maternity blues is defined as a group of psychological and psychosomatic symptoms that generally affect women within 10-15 days after birth and are not considered a pathological condition. Emotional Freedom Techniques (EFT) is an evidence-based method that combines acupressure with elements from cognitive and exposure therapies. EFT has become widely used in medical and psychological treatment settings in recent years. It is also used as a self-help technique by millions of people every year.

For mothers experiencing motherhood blues, the opportunity to freely express and share their feelings can provide emotional relief. This can help reduce stress and make the mother feel more comfortable. Emotional comfort and support of the mother can positively affect breastfeeding performance. Reducing emotional stress can increase milk production and help the mother have a better breastfeeding experience.

For this reason, this study was planned to determine the effect of the emotional liberation technique on breastfeeding in women experiencing motherhood sadness.

Eligibility criteria: Inclusion Criteria:

* Voluntarily agrees to participate in the study,
* Experiencing motherhood blues
* Being over 18 years old

Exclusion Criteria:

* • Leaving the study at any time,

  * Having any obstacle to communication

Primary outcomes:
measure: The Effect of Emotional Freedom Technique on Breastfeeding in Women Experiencing Maternity Blues
timeFrame: Procedure 1: Preliminary tests will be carried out and then the 1st EFT session will be held. 2nd Procedure: After 10 days, the first final tests will be performed and then the second EFT session will be held.
Secondary outcomes:
Other outcomes:
Locations:
city: Edirne
country: Turkey
facility: Trakya University
Study officials:
References:
Clinical trial NCT02140892: A Comparison Study of Two Respiratory Physical Therapy Methods and Standard Medical Treatment for Treating COPD Patients During Acute Exacerbation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Chronic Obstructive Pulmonary Disease
Chronic Bronchitis
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2014-05-16
Enrollment: 75
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: One of the main goals of the respiratory physical therapy is to help people who are suffering from accumulating of secretions in their airways and lungs.

Chronic Obstructive Pulmonary Disease (COPD) patients are often hospitalized with an Acute Exacerbation of their medical condition.

Those patients usually get only the standard medical care during the acute phase and don't get respiratory physical therapy treatment.

The study's main aim is to investigate if respiratory physical therapy treatment in addition to standard medical care during the acute phase, can improve the respiratory and medical condition and reduce hospitalization stay.

In order to do so we will compare three groups of COPD patients during acute exacerbation; two groups will get one out of two respiratory physical therapy techniques; manually or Intrapulmonary Percussive Ventilator (IPV) in addition to standard medical care and the third group will get standard medical care alone.


Eligibility criteria: Inclusion Criteria:

* clinical diagnosis of Acute Exacerbation of COPD or Acute Exacerbation of Chronic Bronchitis
* Respiratory Rate\>25
* PaCO2\> 45 mmHg
* 7.35 \< PH \< 7.38

Exclusion Criteria:

* intubation
* apnea
* glasgow coma scale \< 8
* pneumothorax
* FEV1 \< 50% predicted
* Ischemic Hearth Disease

Primary outcomes:
measure: length of stay in the hospital
timeFrame: up to three months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03504592: Smartphone Utilization for Glucose Monitoring and Antenatal Reporting
Official title: Utilizing mHealth to Improve Diabetes in an Obstetric Population
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Gestational Diabetes
Pregestational Diabetes
Lead sponsor: University of Rochester
Sponsor class: OTHER
First posted: 2018-04-20
Enrollment: 21
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This project will utilize MHealth technology to address the barriers providers and obstetric patients experience when reporting blood glucose results. Half of the participants will record their blood glucose values with the assistance of a smartphone device, the other half will continue in the traditional care method of the clinic.

Detailed description: This will be a prospective single center randomized trial piloting the use of mHealth applications in an obstetric population with diabetes. Participants will be enrolled in the study after the diagnosis of diabetes is made in pregnancy for those with gestational diabetes, or for patients with preexisting diabetes they will be enrolled upon initiation of prenatal care. Participants will be randomized to traditional care or mHealth intervention. Outcomes will include completeness and accuracy of the participant glucose log, unscheduled health care access episodes in the pregnancy, patient satisfaction, percentage of glucose values at goal and percent change in Hemoglobin A1C.

Eligibility criteria: Inclusion Criteria:

* Pregnant, English speaking, Diagnosed with diabetes during pregnancy or with known preexisting diabetes, has smartphone, sees URMC OBGYN for obstetric care in pregnancy.

Exclusion Criteria:

* Not English speaking, does not have smartphone, unable to consent.

Primary outcomes:
measure: Completeness and accuracy of blood glucose record
timeFrame: Every 2 weeks through study completion, up to 42 weeks
Secondary outcomes:
measure: Patient Satisfaction
timeFrame: Once prior to exiting the study, an average of 42 weeks
measure: Glucose values at goal
timeFrame: Every 2 weeks through study completion, up to 42 weeks
measure: % Change in Hemoglobin A1C
timeFrame: Once prior to exiting the study, up to 42 weeks
measure: Clinic visits
timeFrame: through study completion, up to 42 weeks
measure: Unscheduled health care access episodes
timeFrame: through study completion, up to 42 weeks
Other outcomes:
Locations:
city: Rochester
country: United States
facility: UR Medicine Obstetrics and Gynecology
state: New York
Study officials:
References:
Clinical trial NCT04543292: Clinical Evaluation of Polytetrafluoroethylene (PTFE, MATFILL) for the Sealing of Prosthetic Chimneys.
Official title: Clinical Evaluation of Polytetrafluoroethylene (PTFE, MATFILL) for the Sealing of Prosthetic Chimneys.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Edentulous Alveolar Ridge
Lead sponsor: Fundación Eduardo Anitua
Sponsor class: OTHER
Collaborators: name: BTI Biotechnology Institute
First posted: 2020-09-10
Enrollment: 4
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Dental implant supported screwed prosthetic rehabilitations are associated to several advantages, as a minimal occlusal spaced and easier hygiene and maintenance. In this sense, screwed rehabilitations have been associated with lower frequency of biological and technical complications. Nevertheless, the screwing process results in the formation of a prosthetic chimney that requieres an appropriate sealing protocol. This protocol needs to include a material for the protection of the screw head. Nowadays, there is a lack of materials for this intended use with marketing authorisation. Several materials have been tested in the bibliography including PTFE, although there are not high quality studies. In this context, this clinical investigation aims to evaluate the efficacy and safety os a PTFE-based product (MAFILL) for the sealing of prosthetic chimneys and the protection of the screw head.


Eligibility criteria: Inclusion Criteria:

* Age \> 18 years old
* Clinical need for the placement of a implant-supported dental prosthesis
* Clinical need for the filling of the prosthetic chimney
* Signing informed consent

Exclusion Criteria:

* Inability of follow-up

Primary outcomes:
measure: Integrity of screw head
timeFrame: 6 weeks
measure: Integrity of screw head
timeFrame: 6 weeks
Secondary outcomes:
measure: Occurrence of prosthetic complications
timeFrame: 6 weeks
measure: Occurrence of biological complications
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Vitoria
country: Spain
facility: Eduardo Anitua Private Clinic
state: Alava
Study officials:
affiliation: Eduardo Anitua Private Clinic
name: Eduardo Anitua, MD, DDS, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04380792: Prevalence of DVT or PE in Patients Infected With COVID-19 Admitted to Hospital
Official title: Prevalence of DVT or PE in Patients Infected With COVID-19 Admitted to Hospital (SCREENING Study)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19
Lead sponsor: Foundation for the study of VTE diseases. (FUENTE)
Sponsor class: OTHER
First posted: 2020-05-08
Enrollment: 2497
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients infected with COVID-19 admitted to hospital

Brief summary: The main objectives are:

* To establish the prevalence of deep venous thrombosis through ultrasonography in Patients infected with COVID-19 admitted to hospital.
* To identify patients with higher risk of deep venous thrombosis.


Eligibility criteria: Inclusion Criteria:

* Patients infected with COVID-19.
* Admission to hospital.

Exclusion Criteria:

* Patients treated with ECMO (Extracorporeal membrane oxygenation).

Primary outcomes:
measure: VTE events and complications
timeFrame: 30 days
Secondary outcomes:
Other outcomes:
Locations:
city: Badalona
country: Spain
facility: Manuel Monreal
state: Barcelona
Study officials:
affiliation: Germans Trias i Pujol Hospital
name: Manuel Monreal
role: STUDY_CHAIR
References:
Clinical trial NCT05618392: Pain Assessment Following Placement of a Percutaneous Radiologic Gastrostomy and Predictive Factors
Official title: Pain Assessment Following Placement of a Percutaneous Radiologic Gastrostomy and Predictive Factors
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Gastrostomy Complications
Gastrostomy
Lead sponsor: Centre Hospitalier de Valence
Sponsor class: OTHER
First posted: 2022-11-16
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients needing a Percutaneous radiologic Gastrostomy under local anesthesia

Brief summary: A 12 months mono-center, descriptive study, to evaluate pain and predictive factors Following placement of percutaneous Radiologic gastrostomy (PRG).

The primary objective is to evaluate the abdominal pain associated with percutaneous radiologic gastrostomy (PRG) placement.

Detailed description: PRG is a pathway first of all enteral nutrition that has several advantages: local anesthesia, possible in case of esophageal stenosis, Rates of successful tube placement higher for radiologic gastrostomy than for percutaneous endoscopic Gastrostomy (PEG).

Abdominal pain following percutaneous radiologic gastrostomy (PRG) placement is a recognized complication. However, the prevalence and degree of severity of pain are poorly characterized. This pain often requires antalgic treatment.

The primary objective is to evaluate the abdominal pain from Baseline until 7 days after radiologic gastrostomy (PRG) placement.

The secondary objective is to evaluate predictive factors

Eligibility criteria: Inclusion Criteria:

* Needing a radiologic gastrostomy under local anesthesia
* Age ≥ 18 years old
* Read, write and understand the French language

Exclusion Criteria:

* Patient under guardianship, deprived of liberty, safeguard of justice
* Patient presenting a serious psychiatric pathology that does not allow compliance with the completion of the questionnaires (at the discretion of the investigator)
* Refusal to participate in research

Primary outcomes:
measure: abdominal pain
timeFrame: 7 days
measure: predictive factors
timeFrame: DAY 1
Secondary outcomes:
Other outcomes:
Locations:
city: Valence
country: France
facility: Sandrine Beauchard
Study officials:
References:
Clinical trial NCT00042692: Catechol Thioethers in Parkinson's Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Parkinson's Disease
Keywords: catechol thioethers
Parkinson's disease
neurodegenerative disease
Lead sponsor: National Institute of Environmental Health Sciences (NIEHS)
Sponsor class: NIH
First posted: 2002-08-06
Enrollment: 20
Sex: ALL
Minimum age (years): 0
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: NATURAL_HISTORY
Time perspective: OTHER

Brief summary: The goal of the clinical trial aim in this project is to test whether catechol thioethers can be used as biomarkers of dopaminergic neurodegeneration.


Eligibility criteria: First diagnosis of Parkinson's disease.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06628492: Surgical Guided Fabricated From Two Different Printing Materials
Official title: Comparative Assessment for the Positional Accuracy of Dental Implants Inserted by Computerized Surgical Guides Fabricated From Different Printing Materials
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Partial-edentulism
Lead sponsor: Suez Canal University
Sponsor class: OTHER
First posted: 2024-10-08
Enrollment: 12
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: implant will be inserted in patients with kennedy class 3 or 4 partially edentulous mandible .the implants will be inserted using teeth supported surgical guide fabricated from two different materials


Eligibility criteria: Inclusion Criteria:

1. Patients with skeletal Angle´s class I maxilla-mandibular relationship,
2. adequate inter-arch distance, have Kennedy class 3 or 4 partially edentulous mandible of more than 2 teeth missed and will be applied for the treatment of tooth loss and requiring fixed prosthodontic rehabilitation
3. normal Physical and psychological status to tolerate conventional implant procedures,
4. Their residual ridge had sufficient bone volume for implant installation and was covered by firm mucoperiosteum.

Exclusion Criteria:

1. Smokers.
2. Patients undergoing chemotherapy or radiotherapy and immunocompromised patients.
3. Patients with, systemic disease that might complicate post-operative healing or contribute to bone resorption, e.g uncontrolled diabetes, psychological disorders, or alcohol, tobacco, or drug abuse
4. parafunctional habits, poor oral hygiene, limited mouth opening, severe alveolar bone deficiencies,

Primary outcomes:
measure: linear deviation of inserted implant
timeFrame: 1 month
measure: angular deviation of inserted implant
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: