Clinical trial NCT05490420: Effects of Upper Extremity Manual Lymphatic Drainage on Symptom Severity, Hand Functions, Electrophysiological and Ultrasonographic Measurements in Carpal Tunnel Syndrome
Official title: Effects of Upper Extremity Manual Lymphatic Drainage on Symptom Severity, Hand Functions, Electrophysiological and Ultrasonographic Measurements in Carpal Tunnel Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Carpal Tunnel Syndrome
Keywords: carpal tunnel syndrome
manual lymphatic drainage
surface electromyography
Lead sponsor: Istanbul Medeniyet University
Sponsor class: OTHER
First posted: 2022-08-05
Enrollment: 27
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: randomized controlled trial
Primary purpose: TREATMENT

Brief summary: This study is aimed to investigate the effects of upper extremity manual lymphatic drainage, which is applied to remove edema from the carpal tunnel region in addition to conventional exercise therapy in Carpal tunnel syndrome patients on findings of clinical, ultrasonographic, and electrophysiological.

Detailed description: Thirtyfour volunteer participants between aged 40 and 60 years, who met the inclusion criteria, will be included in the study. Participants will be randomly divided into two groups experimental and control groups. While the control group will receive only conventional exercises, the experimental group will receive both conventional exercises and upper extremity manual lymphatic drainage. A total of 3 measurements will be made before the treatment, after the treatment and 1 month after the end of the treatment. Symptom severity will be evaluated via Boston carpal tunnel syndrome questionnaire, grip strength via hand dynamometer, pressure pain threshold via digital algometer device, cross-sectional area of the median nerve via ultrasound, and median nerve conduction velocity via superficial EMG device.

Eligibility criteria: Inclusion Criteria:

* People aged between 40-60 years
* Having been diagnosed with carpal tunnel syndrome (CTS) at least 6 months ago or having symptoms related to carpal tunnel syndrome for at least 6 months
* Having mild (median nerve sensory conduction velocity below 40 m/sec) and moderate (median nerve sensory conduction velocity below 40 m/sec and median motor distal latency 4 ms and above) CTS according to electrophysiological findings
* Not having received medical treatment and/or physiotherapy for CTS in the last 6 months

Exclusion Criteria:

* Having cervical radiculopathy
* Having thoracic outlet syndrome
* Presence of systemic disease that may lead to CTS, such as diabetes or thyroid disease
* Pregnancy
* Presence of anemia
* Having a history of CTS surgery
* Presence of radial or ulnar nerve sensory-motor lesions accompanying the present condition
* Presence of lymphedema
* Having severe (Sensory nerve action potential cannot be obtained) and severe (Sensory nerve action potential cannot be obtained, but combined muscle action potential is not present) CTS according to electrophysiological findings

Primary outcomes:
measure: Symptom severity
timeFrame: Change from baseline symptom severity at week 6 and 10.
measure: Grip strength
timeFrame: Change from baseline grip strength at week 6 and 10.
measure: Pressure pain threshold (PPT)
timeFrame: Change from baseline pressure pain threshold at week 6 and 10.
measure: Cross-sectional area of the median nerve
timeFrame: Change from baseline cross-sectional area of the median nerve at week 6 and 10.
measure: Sensory Velocity of median nerve
timeFrame: Change from baseline Sensory Velocity of median nerve at week 6 and 10.
measure: Motor velocity of median nerve
timeFrame: Change from baseline motor velocity of median nerve at week 6 and 10.
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Emel Mete
Study officials:
References: