Clinical trial NCT06889714: Investigation of the Effects of Frailty and Sarcopenia on Postoperative Recovery and Complications in Geriatric Patients
Official title: Investigation of the Effects of Frailty and Sarcopenia on Postoperative Recovery and Complications in Geriatric Patients Undergoing Colorectal Cancer Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Frailty
Sarcopenia
Keywords: geriatric anesthesia
sarcopenia
ultrasonography
postoperative complications
quadriceps femoris
Lead sponsor: Eskisehir Osmangazi University
Sponsor class: OTHER
First posted: 2025-03-21
Enrollment: 42
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 42 patients over 60 years of age with ASA score I-III who were to undergo colorectal malignancy surgery under general anesthesia

Brief summary: After obtaining ethical approval, 42 patients with American Society of Anesthesiologists (ASA) scores I-III who were scheduled for surgery under general anesthesia were included in our prospective study. Patients were monitored in the preoperative preparation room in the operating room and frailty was assessed using the FRAIL scale and sarcopenia was assessed using the STAR ratio. The thickness of the rectus femoris and vastus intermedius muscles of the patients was measured and recorded by ultrasonography. Thigh lengths were measured and recorded. Rectus Femoris/Thigh Length (RF/B), Vastus Intermedius/Thigh Length (VI/B), and Total Muscle Thickness/Thigh Length (T/B) were calculated and recorded. Patients were followed up according to the Modified Aldrete Score after surgery in the anesthesia recovery unit, and the time to reach 9-10 points was recorded, and the time to leave the recovery unit was recorded. Postoperatively, complications were followed up according to the Clavien-Dindo Classification, and discharge times from the hospital were recorded.

Detailed description: Frailty is a clinically identifiable state of heightened vulnerability resulting from age-related declines in physiological systems and functions, leading to impaired resilience to stressors. Frailty is highly prevalent among the elderly and is associated with an increased risk of falls, disability, hospitalization, and mortality. Magnetic resonance imaging (MRI) and computed tomography (CT) are considered the gold standard for sarcopenia diagnosisCT is also limited due to radiation exposure and similar logistical constraints. In contrast, ultrasonography (USG) is portable, cost-effective, and can be performed at the bedside without radiation exposure.

Using high-frequency ultrasound probes, peripheral muscle tissues and their dimensions can be rapidly assessed.

Eligibility criteria: Inclusion Criteria:

* patients over 60 years of age who are undergoing colorectal malignancy surgery under general anesthesia
* patients willing to participate in the study
* Patients with ASA score I-III

Exclusion Criteria:

* Patients with Parkinson's disease,
* Alzheimer's disease,
* history of cerebrovascular events,
* neuromuscular disease,
* cognitive dysfunction,
* severe liver disease,
* severe heart disease,
* impaired cooperation due to kidney disease,
* emergency and trauma patients,
* patients with bilateral lower extremity amputations

Primary outcomes:
measure: age
timeFrame: 1 year
measure: sex
timeFrame: 1 year
measure: height
timeFrame: 1 year
measure: body weight
timeFrame: 1. year
measure: educational status
timeFrame: 1 year
measure: marital status
timeFrame: 1 year
measure: ASA score
timeFrame: 1 year
measure: rectus femoris muscle thickness
timeFrame: 1 year
measure: vastus intermedius(VI) thickness
timeFrame: 1 year
measure: rectus femoris-to-thigh length ratio
timeFrame: 1 year
measure: vastus intermedius-thigh length ratio
timeFrame: 1 year
measure: total muscle thickness to thigh length ratio
timeFrame: 1 year
measure: frailty score
timeFrame: 1 year
measure: recovery time from anesthesia
timeFrame: 1 year
measure: hospital discharge time
timeFrame: 1 year
measure: Modified Clavien-Dindo Classification
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Eski̇şehi̇r
country: Turkey
facility: University of Eskisehir Osmangazi
state: Odunpazarı
Study officials:
affiliation: University of Eskişehir Osmangazi
name: ferda yaman, Assoc prof
role: PRINCIPAL_INVESTIGATOR
References: