Clinical trial NCT00367562: Inhibition of the Renin Angiotensin System Plus Corticosteroids for the Treatment of Proteinuria in IGA Nephropathy
Official title: Phase IV Open Label Uncontrolled Trial of the Dual Blockade of the Renin Angiotensin System With Enalapril Plus Valsartan Combined With Oral Methylprednisolone for the Treatment of Proteinuria in IGA Nephropathy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: IGA Nephropathy
Keywords: IGA NEPHROPATHY
STEROIDS
ENALAPRIL
VALSARTAN
PROTEINURIA
IMMUNOGLOBULIN A NEPHROPATHY (IGA NEPHROPATHY)
Lead sponsor: Hospital Britanico
Sponsor class: OTHER
First posted: 2006-08-23
Enrollment: 20
Sex: ALL
Minimum age (years): 21
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: TO ASSESS THE EFFICACY OF THE RENIN ANGIOTENSIN SYSTEM PLUS STEROIDS TO DECREASE THE AMOUNT OF PROTEINURIA IN IGA NEPHROPATHY

Detailed description: Patients whose proteinuria was \> 0.5 g/day were to receive enalapril plus valsartan coupled with oral 0.5 g/day of methylprednisone for 6 months.

Eligibility criteria: Inclusion Criteria:

* PATIENTES WITH IGA NEPHROPATHY WITH PROTEINURIA OVER 0.5 G/DAY

Exclusion Criteria:

* MALIGNANCY, RENAL FAILURE

Primary outcomes:
measure: DAILY PROTEINURIA
Secondary outcomes:
measure: RENAL FUNCTION AS ASSESSED BY SERUM CREATININE
Other outcomes:
Locations:
city: Buenos Aires
country: Argentina
facility: Hospital Britanico de Buenos Aires
Study officials:
affiliation: Hospital Britanico
name: hernan trimarchi, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
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