Clinical trial NCT05307276: Limitation of the Ventilatory Response to Exercise in the Master Athlete
Official title: Limitation of the Ventilatory Response to Exercise in the Master Athlete: Influences on Locomotor Muscle Fatigue and on Endurance Performance
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Healthy Volunteers
Lead sponsor: Centre Hospitalier Universitaire de Nice
Sponsor class: OTHER
First posted: 2022-04-01
Enrollment: 3
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Following the selection visit (#V0) to verify the inclusion and non-inclusion criteria, participants will make 2 visits (#V1 and #V2) including in particular a Respiratory Functional Exploration (EFR) and a triangular VO2 MAX estimation test in Ambient Air or Heliox conditions (depending on randomization).
Primary purpose: OTHER

Brief summary: It is generally accepted that the ventilatory system is not a limiting factor in physical exercise in terms of performance or exercise tolerance in healthy subjects. The ventilatory system would be oversized in relation to the stresses it has to cope with, even during maximum intensity exercise. However, some highly trained endurance athletes may be exceptions to this rule. A limitation of the expiratory flow is indeed sometimes found in these athletes, whose maximum values of ventilation can confront the mechanical limits of their ventilatory system. This phenomenon could be accentuated in elderly athletes (known as "master athletes") under the effect of structural and functional pulmonary alterations that accompany aging. Our hypothesis : What is the prevalence of exercise expiratory flow limitation in the master athlete and does it cause a decrease in physical performance via an acceleration of locomotor muscle fatigue?


Eligibility criteria: Inclusion Criteria:

* Non-smoker (active or passive) or ex-smoker of less than 5 pack-years and stopped for more than 10 years.
* No known significant chronic pathology.
* No symptoms suggesting a progressive pathology.
* No contraindication to physical exercise. Normal Pulmonary Functional Test (PFT).
* Participants affiliated to the social security system

Exclusion Criteria:

* Vulnerable persons as defined in Articles L. 1121-5 to L.1121-8 and L.1122-1-2 of the Public Health Code (e.g. persons deprived of liberty, minors, adults protected, etc.),
* Participants with a medical contraindication to sports practice,
* Cardiovascular, respiratory, neuromuscular and/or significant metabolic,
* Participants with declared pathology or medical treatment,
* Smoking or drug use,
* Significant chronic drug treatment,
* Lack of consent.
* Refusal to cooperate
* Recent rhino-bronchial infection (within last 4 weeks)
* Mental disability

Primary outcomes:
measure: Change from baseline severity of EFL during ergocycle endurance exercise
timeFrame: At inclusion and 3 months
Secondary outcomes:
measure: Muscle activation level
timeFrame: At inclusion and 3 months
Other outcomes:
Locations:
city: Nice
country: France
facility: CHU de Nice
state: Alpes-maritimes
Study officials:
affiliation: Pneumologie, CHU de Nice
name: Leroy Sylvie
role: PRINCIPAL_INVESTIGATOR
References: