Clinical trial NCT04425395: The Effect of Nonverbal Vocalisations on Pain Tolerance
Official title: The Effect of Nonverbal Vocalisations on Pain Tolerance
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Healthy
Keywords: nonverbal vocal communication
pain tolerance
cold pressor test
Nociception Level Index
Video pupillometry
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
Collaborators: name: Laboratoire ENES-CNPS (Université Lyon/Saint Etienne)
First posted: 2020-06-11
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Humans produce non-verbal vocalizations (shouting, growling, screaming), laughter, ...) in various contexts that are likely to perform biological functions.

and important social issues. Yet despite their importance in the human vocal repertoire, the mechanisms and functions of non-verbal vocalizations remain little studied and poorly understood including in humans. In this context, the investigators wish to examine how the production of vocalizations non-verbal communication influences pain tolerance in healthy adults.

Detailed description: Humans produce nonverbal vocalisations such as screams, grunts, roars, cries and laughter across a variety of contexts. Yet despite the prominence and apparent importance of these nonverbal sounds in human communication, the investigators still know very little about their influence on human perception and behaviour. That's why, in this study, the investigators will examine specifically the influence of nonverbal vocal production on pain tolerance.

The remainder of the study will involve up to three trials of a pain tolerance (cold pressor) task, during which the investigators will ask participants to produce vocalisations (e.g., screams or words) while submerging the participant's hand in bath of circulating cold water.

The results of the study will contribute to our theoretical understanding of the functions of nonverbal vocal communication in humans, in particular the influence of nonverbal vocal production (i.e., yelling) on pain tolerance.

Eligibility criteria: Inclusion Criteria:

* Participant in good health
* Affiliated or entitled participant in a social security scheme
* Participant who has received informed information about the study and has co-signed a consent to participate in the study with the investigator.

Exclusion Criteria:

* Chronic pain
* High blood pressure or poor circulation
* Cardiac or vascular disease, or a heart condition (including symptoms of Raynaud's syndrome)
* Allergy or hypersensitivity to cold
* Diabetes
* Epilepsy
* Pregnancy
* Recent serious injury
* Neurological or psychiatric condition known to affect pain tolerance (e.g., peripheral neuropathy, schizophrenia)
* History of fainting or seizures
* History of frostbite
* Chronic smoker (more than 10 cigarettes a day)

Primary outcomes:
measure: Pain tolerance
timeFrame: at inclusion
Secondary outcomes:
measure: Onset of pain
timeFrame: at inclusion
measure: Pain intensity
timeFrame: at inclusion
measure: correlation between NOL index and pupillary diameter
timeFrame: at inclusion
measure: Analysis of Acoustic Recordings
timeFrame: at inclusion
Other outcomes:
Locations:
city: Saint-Étienne
country: France
facility: Centre Hospitalier Universitaire Saint-Etienne
Study officials:
affiliation: CHU SAINT-ETIENNE
name: Roland PEYRON, MD
role: PRINCIPAL_INVESTIGATOR
References: