Clinical trial NCT03181672: Stellate Ganglion Block on Tourniquet Response
Official title: Influence of Stellate Ganglion Block on Tourniquet Response in Lower Limbs.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Stellate Ganglion Block
Keywords: Stellate ganglion block Tourniquet reaction
Lead sponsor: The Affiliated Hospital of Xuzhou Medical University
Sponsor class: OTHER
First posted: 2017-06-09
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To investigate the influence of stellate ganglion block on tourniquet response during surgery in patients undergoing elective lower limb Department of orthopedics.

Detailed description: Select elective general anesthesia in 100 cases of lower extremity Department of orthopedics surgery patients were randomly divided into SGB group and control group, SGB group received anesthesia before the right stellate ganglion block intervention, the control group underwent right deltoid muscle injection, changes in hemodynamics in two groups were recorded in heart rate, blood pressure, and before anesthesia, after intubation 3min 1H, a tourniquet, tourniquet release before and after tourniquet release 3min, 30min, changes in blood physiological analysis. The effect of stellate ganglion block on tourniquet response during perioperative period was observed.

Eligibility criteria: Inclusion Criteria:

* American Society of anesthesiologists Grade 1-3 Patients
* undergoing lower limb surgery under general anesthesia
* should be treated with tourniquet

Exclusion Criteria:

* Tourniquet application time is less than 1h, greater than 1.5h
* Abnormal coagulation function
* perioperative application of hormone
* lidocaine allergy
* can not cope with nerve block
* nerve block failure
* minimally invasive surgery

Primary outcomes:
measure: blood pressure
timeFrame: 2 hours in perioperative period
measure: heart rate
timeFrame: 2 hours in perioperative period
measure: Lac
timeFrame: One minute after the radial artery puncture, the tourniquet was applied for 1 hours and the tourniquet was released 3 minutes after the tourniquet release 30 minutes
measure: cortisol
timeFrame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
measure: norepinephrine
timeFrame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
timeFrame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
measure: ET-1
timeFrame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
measure: MDA
timeFrame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
measure: SOD
timeFrame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
measure: IL-6
timeFrame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
measure: cTn-T
timeFrame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
measure: postoperative pain
timeFrame: hour 1、hour 6、hour 24、hour 48 after operation
Secondary outcomes:
measure: Complication of puncture
timeFrame: 2 hours in perioperative period
Other outcomes:
Locations:
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical University
state: Jiangsu
Study officials:
affiliation: The Affiliated Hospital of Xuzhou Medical University
name: Tie Xu, MD
role: STUDY_DIRECTOR
References:
citation: Arai YC, Ogata J, Matsumoto Y, Yonemura H, Kido K, Uchida T, Ueda W. Preoperative stellate ganglion blockade prevents tourniquet-induced hypertension during general anesthesia. Acta Anaesthesiol Scand. 2004 May;48(5):613-8. doi: 10.1111/j.0001-5172.2004.00389.x.