Clinical trial NCT06628531: SLI & Pulmonary HA Deposition After SAH
Official title: Relationship Between Acute Lung Injury and Pulmonary Hyaluronic Acid Deposition After Subarachnoid Hemorrhage
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Subarachnoid Haemorrhage (SAH)
Keywords: Subarachnoid haemorrhage
SAH
acute lung injury
ALI
hyaluronic acid
Lead sponsor: Tianjin Medical University
Sponsor class: OTHER
First posted: 2024-10-08
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Estimated by statistical analysis, a total of 24 subjects were included from patients admitted to the neurosurgical intensive care unit of Tianjin Medical University General Hospital and the intensive care unit of Tianjin Huanhu Hospital due to aneurysmal SAH.

Brief summary: Acute lung injury is a common complication of subarachnoid hematoma (SAH), and a significant risk factor for death in patients with SAH. Unlike neurogenic pulmonary edema and pneumonia following brain injury, the clinical causes of pulmonary injury after SAH are not intracranial hypertension or pulmonary infection. Its occurrence is influenced by the release of catecholamines, the regulatory function of the hypothalamic-pituitary-adrenal (HPA) axis and systemic inflammatory response, but the specific mechanisms are still unclear. Therefore, delving into the pathological mechanisms of SAH-induced lung injury and developing therapeutic strategies based on the findings is of great importance to improve the prognosis of patients.

Abnormal accumulation of hyaluronic acid in the lungs has been reported to be closely related to the pathological progression of various pulmonary injury diseases, such as chest trauma, pulmonary infection and chronic obstructive pulmonary disease. From this, the present research is aimed to explore the levels and dynamic changes of hyaluronic acid in the bronchoalveolar lavage fluid and blood of patients with acute lung injury following SAH, and to analyze its correlation with the prognosis of pulmonary complications, thereby providing assistance for the clinical diagnosis and treatment of SAH.


Eligibility criteria: Inclusion Criteria:

* Age between 18 and 80 years old with independent behavior ability or authorized legal representative.
* A documented diagnosis of SAH within 5 days.
* A Hunt-Hess scale of Ⅳ or Ⅴ.
* Absence of clinical and etiological evidence of pulmonary infection.

Exclusion Criteria:

* Pregnant or lactating women.
* Present history of traumatic brain injury or intracranial hemorrhage.
* Past history of neurological disorders, lung infection within the past six months, cancer, chronic cardiopulmonary diseases, hematological diseases or renal failure.
* Have participated in clinical trials in the past 4 weeks.
* The investigator considers that not appropriate for inclusion.

Primary outcomes:
measure: Hyaluronic acid level in bronchoalveolar lavage fluid after SAH
timeFrame: During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH
measure: Inflammatory cytokines levels in bronchoalveolar lavage fluid after SAH
timeFrame: During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH
Secondary outcomes:
measure: Serum hyaluronic acid level after SAH
timeFrame: During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH
measure: Serum inflammatory cytokines levels after SAH
timeFrame: During the acute phase (1-5 days post-onset) and the chronic phase (10-14 days post-onset) of patients with SAH
Other outcomes:
Locations:
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
Study officials:
affiliation: Tianjin Medical University General Hospital
name: Xintong Ge
role: STUDY_CHAIR
affiliation: Tianjin Huanhu Hospital
name: Yadan Li
role: PRINCIPAL_INVESTIGATOR
affiliation: Tianjin Medical University General Hospital
name: Ye Tian
role: PRINCIPAL_INVESTIGATOR
References: