louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00079794: Iscar for Supplemental Care in Stage IV Lung Cancer
Official title: Iscar for Supplemental Care in Stage IV Lung Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Lung Cancer
Keywords: lung cancer
herbal medicine
non-small cell cancer
Iscar
mistletoe
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH)
Sponsor class: NIH
First posted: 2004-03-16
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study it to determine whether supplemental treatment with Iscar improves immune function and quality of life among Stage IV non-small cell lung carcinoma patients receiving conventional chemotherapy. Iscar is an herbal medicine made from the total plant extract of mistletoe. this preparation is already in use in Europe and its use in the US is likely to increase as cancer patients continue to seek alternative therapies.

Detailed description: See Brief Summary

Eligibility criteria: Inclusion Criteria:

* Stage IV NSCLC patients who receive standard chemotherapy

Exclusion criteria:

* Known allergy to Viscum Album L.
* Concomitant use of other mistletoe products
* Concomitant use of mushroom glucan and proteoglycan extracts
* Concomitant use of thymus extract products
* Inability to self-report quality of life utilizing assessment tools
* Ongoing steroid or ACTH therapy
* Co-morbid immunocompromised state
* Pregnancy
* Participation in other clinical trials

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Thomas Jefferson University
state: Pennsylvania
Study officials:
affiliation: Jefferson Medical College of Thomas Jefferson University
name: Steven Rosenzweig, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02847494: Corticosteroids for Acute Migraine in the Emergency Department
Official title: Corticosteroids for Acute Migraine. An ED-based, Randomized, Comparative Effectiveness Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Migraine
Lead sponsor: Montefiore Medical Center
Sponsor class: OTHER
First posted: 2016-07-28
Enrollment: 220
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This is an emergency department based randomized trial in which we compare two different treatment for migraine headache. The goal is to decrease the number of headache days during the week after ED discharge.


Eligibility criteria: Inclusion Criteria:

* Migraine without aura criteria (International Classification of Headache Disorders 3B )
* Headache rated as moderate or severe in intensity

Exclusion Criteria:

* Concern for secondary cause of headache
* Contra-indications to investigational medications

Primary outcomes:
measure: Headache Days as Self-reported by Participants
timeFrame: 7 days after discharge from emergency department
Secondary outcomes:
measure: Number of Participants With Sustained Headache Freedom
timeFrame: 7 days after discharge from emergency department
measure: Medication Preference as Assessed by Self-report
timeFrame: 7 days after discharge from emergency department
Other outcomes:
Locations:
city: Bronx
country: United States
facility: Montefiore Medical Center--Einstein
state: New York
city: Bronx
country: United States
facility: Montefiore Medical Center-Moses
state: New York
Study officials:
affiliation: Albert Einstein College of Medicine
name: Benjamin W Friedman, MD, MS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Latev A, Friedman BW, Irizarry E, Solorzano C, Restivo A, Chertoff A, Zias E, Gallagher EJ. A Randomized Trial of a Long-Acting Depot Corticosteroid Versus Dexamethasone to Prevent Headache Recurrence Among Patients With Acute Migraine Who Are Discharged From an Emergency Department. Ann Emerg Med. 2019 Feb;73(2):141-149. doi: 10.1016/j.annemergmed.2018.09.028. Epub 2018 Nov 16.
Clinical trial NCT05905094: Postural Correction Exercises Effect on Forward Head Posture
Official title: Effect of Postural Correction Exercise on Cervical Sagittal Posture, Proprioception, ROM and Head Flexion Angle in Forward Head Posture Among University Students.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Musculoskeletal Disorder of the Neck
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-06-15
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Quasi-experimental study
Primary purpose: SUPPORTIVE_CARE

Brief summary: To determine the effect of postural correction exercise in universities students regarding cervical sagittal posture, head flexion angle in forward head posture.

Detailed description: Informed consent will be taken from the participants, then we move further toward their demographics which will lead to initial readings after completion of authenticated questionnaire, then application of performing technique/exercise protocol by therapist and note the measurements again then interpret and analyze the data through data analyzing software which will lead to conclude the process.

Eligibility criteria: Inclusion Criteria:

* University students of age between 18 to 30 years.
* Smart devices addictions for one or more than one year and 2 h per day.
* CVA of less than 54°.
* Smartphone Addicted scale - short version SAS-SV

Exclusion Criteria:

* History of neurological symptoms and surgery to the neck and/or upper limbs.
* Smart devices usage less than one year.
* Unable to perform the exercises

Primary outcomes:
measure: Smartphone Addicted scale - short version SAS-SV
timeFrame: 6 months
measure: goniometery
timeFrame: 6 months
measure: Cranio-vertebral angle
timeFrame: 6 months
Secondary outcomes:
measure: Propioception
timeFrame: 6 months
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: RIPHAH international university Lahore
state: Punjab
Study officials:
affiliation: Riphah International University
name: Muhammad Sanaullah, MS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Shaghayegh Fard B, Ahmadi A, Maroufi N, Sarrafzadeh J. Evaluation of forward head posture in sitting and standing positions. Eur Spine J. 2016 Nov;25(11):3577-3582. doi: 10.1007/s00586-015-4254-x. Epub 2015 Oct 17.
citation: Kim SY, Kim NS, Kim LJ. Effects of cervical sustained natural apophyseal glide on forward head posture and respiratory function. J Phys Ther Sci. 2015 Jun;27(6):1851-4. doi: 10.1589/jpts.27.1851. Epub 2015 Jun 30.
citation: Sahrmann S, Azevedo DC, Dillen LV. Diagnosis and treatment of movement system impairment syndromes. Braz J Phys Ther. 2017 Nov-Dec;21(6):391-399. doi: 10.1016/j.bjpt.2017.08.001. Epub 2017 Sep 27.
Clinical trial NCT04919694: Combination of Orbital Compression Surgery and Strabismus Surgery for Thyroid Associated Ophthalmopathy
Official title: The Therapeutic Effect of Combination of Orbital Compression Surgery and Strabismus Surgery in Patients With Moderate to Severe Thyroid Associated Ophthalmopathy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Thyroid Associated Ophthalmopathy
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2021-06-09
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether combination of orbital compression surgery with strabismus surgery is better than strabismus surgery after orbital compression surgery in the treatment of moderate-to-severe thyroid associated ophthalmopathy

Detailed description: This study will be a interventional case series. Patients with moderate-to-severe thyroid associated ophthalmopathy will be randomized to receive combination of orbital compression surgery with strabismus surgery or strabismus surgery after orbial compression surgery.Patients will be followed for 6 months.

Eligibility criteria: Inclusion Criteria:

* moderate-to-severe thyroid associate ophthalmopathy
* CAS≤3 score
* monocular strabismus,deviation≥20° or 35▲
* stable thyroid function for at least 6 months, confirmed by an endocrinologist

Exclusion Criteria:

* any previous disease in the study eye.
* any previous systematic disease

Primary outcomes:
measure: quality of life ,measured by GO-QoL(quality of life with Grave's Orbitopathy) .
timeFrame: 6 weeks after surgery
measure: quality of life, measured by GO-QoL(quality of life with Grave's Orbitopathy) .
timeFrame: 6 months
Secondary outcomes:
measure: strabismus status
timeFrame: 6 weeks after surgery
measure: strabismus status
timeFrame: 6 months after surgery
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Zhongshan Ophthalmic Center, Sun Yat-sen University
state: Guangdong
Study officials:
References:
Clinical trial NCT05229094: EVA Nexus Vitrectomy Device Field Observation Study
Official title: EVA Nexus Field Observation Study. A Monocentric, Academic Field Observation Study of a Prototype of a New CE-labeled Vitrectomy Device Developed by DORC BV (The Netherlands).
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Retina Disorder
Vitreous Disorder
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2022-02-08
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients that are scheduled for intra-ocular surgery regardless of the indication:

* Vitrectomy surgery
* Cataract surgery
* Vitrectomy combined with cataract surgery

Brief summary: determine the safety and effectiveness of the device.

Detailed description: To perform a field observation study using the newly developed EVA Nexus vitrectomy device.

Patients that are scheduled for intra-ocular surgery regardless of the indication:

* Vitrectomy surgery
* Cataract surgery
* Vitrectomy combined with cataract surgery

Eligibility criteria: Inclusion Criteria:

* Patients that are scheduled for intra-ocular surgery regardless of the indication:
* Vitrectomy surgery
* Cataract surgery
* Vitrectomy combined with cataract surgery
* In case of (combined) vitrectomy: primary or repeat vitrectomy
* General or retrobulbar anesthesia, the latter can be combined with sedation
* Patients aged ≥ 18 years

Exclusion Criteria:

* Patients aged \< 18 years

Primary outcomes:
measure: to evaluate the intra-operative safety of a new surgical device
timeFrame: 2 days
Secondary outcomes:
measure: To evaluate the possible reduction of total surgical time
timeFrame: 1 day
measure: To evaluate the impact of usage of the EVA NEXUS on the surgical parameters used during the procedure
timeFrame: 2 days
measure: To evaluate possible (S)AE that may be related to the use of the surgical platform.
timeFrame: 2 days
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: UZ Leuven
Study officials:
affiliation: UZ Leuven
name: Peter Stalmans, Phd
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01148394: Enhanced Recovery After Colorectal Surgery
Official title: Impact of the Introduction of a Multimodal Rehabilitation Programme for Colorectal Patients. A Prospective Randomized Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Fast Track
Enhanced Recovery
Keywords: Colorectal surgery
multimodal rehabilitation
fast track
early feeding
Lead sponsor: University of Valencia
Sponsor class: OTHER
First posted: 2010-06-22
Enrollment: 119
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Introduction: Multimodal rehabilitation (MMR), combines various elements in the management of the surgical patient which lead to a decrease in surgical stress and a more comfortable and faster postoperative recovery.

Objective: To assess the introduction of MMR in a specialized Colorectal Unit and compare the results with the traditional model assessing its´ efficacy as to recovery, and reduction of hospital stay and costs.

Detailed description: Materials y Methods: A prospective randomized trial was conducted which analyzed 119 patients who underwent elective colorectal surgery between 2009 and 2010. 58 patients were assigned to the traditional group and 61 patients to the MMR group. MMR included preoperative education, early feeding and mobilisation.

Eligibility criteria: Inclusion Criteria:

* Patients who underwent elective colorectal surgery between 2009 and 2010.
* Signed informed consent
* Live in Valencia metropolitan area

Exclusion Criteria:

* Emergency surgery
* No colonic resection
* Unable to continue follow-up
* Dependent on others for daily activities

Primary outcomes:
measure: Postoperative stay
timeFrame: 18 months
Secondary outcomes:
measure: Postoperative complications
timeFrame: 18 months
Other outcomes:
Locations:
Study officials:
affiliation: Hospital Clinico Universitario Valencia
name: Stephanie A Garcia Botello, MBChB
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital Clinico Universitario, Valencia
name: Eduardo Garcia-Granero, MD
role: STUDY_CHAIR
References:
citation: Garcia-Botello S, Canovas de Lucas R, Tornero C, Escamilla B, Espi-Macias A, Esclapez-Valero P, Flor-Lorente B, Garcia-Granero E. [Implementation of a perioperative multimodal rehabilitation protocol in elective colorectal surgery. A prospective randomised controlled study]. Cir Esp. 2011 Mar;89(3):159-66. doi: 10.1016/j.ciresp.2010.12.004. Epub 2011 Feb 22. Spanish.
Clinical trial NCT00815594: Bleb Vascularity Change After Subconjunctival Injection Bevacizumab
Official title: Bleb Vascularity Change After Subconjunctival Injection of Bevacizumab
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Bleb Vascularity
Conjunctival Scarring
Keywords: bleb
vascular change
bevacizumab
trabeculectomy
Bleb vascularity associated with increased scarring activity
Conjunctival scarring finally leads to the obstruction of the fistula tract created by the filtering surgery
the recombinant human anti-VEGF antibody could inhibit angiogenesis of conjunctiva.
Lead sponsor: Capital Medical University
Sponsor class: OTHER
First posted: 2008-12-30
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The occurrence of conjunctival scarring finally leads to the obstruction of the fistula tract created by the filtering surgery. Vascular endothelial growth factor is thought to be a key role in the formation of conjunctival scar, which play a pivotal role in the wound-healing process. So it seems that the recombinant human anti-VEGF antibody could inhibit angiogenesis, and reduce the conjunctival vascular formation in the wound-healing process after glaucoma filtering surgery.


Eligibility criteria: Inclusion Criteria:

* Glaucoma patients after trabeculectomy whose bleb is hyperaemia

Exclusion Criteria:

* Affected eye has normal IOP
* Not allergic with Avastin

Primary outcomes:
measure: bleb vascular change
timeFrame: one day, one week, one month
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Tongren hospital
state: Beijing
Study officials:
affiliation: An ophthalmologist in Tongren hospital
name: Liu Xuan, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00837694: Snack Food Reinforcement in Obese and Non-obese Women
Official title: Differential Effects of Daily Snack Food Intake on Reinforcing Value of Food in Obese and Non-obese Women.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Keywords: BMI
obesity
sensitization
food reinforcement
snack food
Portion size of daily snacks
Weight status
Lead sponsor: State University of New York at Buffalo
Sponsor class: OTHER
First posted: 2009-02-05
Enrollment: 65
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women ages 18 - 50 years who were obese (body mass index \>/= 30) or non-obese (BMI \< 30)

Brief summary: Food reinforcement, motivation to obtain food, is associated with energy intake and obesity. Finding ways to decrease the reinforcing value of unhealthy foods may help with adherence to diets and weight loss. Our previous study in non-obese adults showed that daily consumption of the same snack food (food typically consumed outside of meals) for 14 days significantly decreased its reinforcing value. The purpose of this study was to replicate and extend these findings to obese individuals as well as to examine effects of different portion sizes of snack foods on food reinforcement. Thirty-one obese (body mass index \> 30 kg/m2) and 27 non-obese (BMI \< 30 kg/m2) women had food reinforcement and liking tested at baseline and after two weeks of daily consumption of either 0 kcal, 100 kcals, or 300 kcals daily of the same snack food.


Eligibility criteria: Inclusion Criteria:

* women
* non-smoker
* not on a diet
* no restrained eating
* had to like potential snack foods
* willing to visit the laboratory 3 times
* willing to eat snacks provided
* no medications or medical conditions that affect appetite
* no food allergies

Exclusion Criteria:

* see above

Primary outcomes:
measure: Number of Responses Made by Clicking a Mouse Button for Food
timeFrame: During 2nd and 3rd visits
measure: Energy Intake
timeFrame: visits 1, 2, and 3 plus on the phone throughout the study.
Secondary outcomes:
measure: Body Weight
timeFrame: visit 1 and visit 3
measure: Height
timeFrame: visits 1 and 3
Other outcomes:
Locations:
city: Buffalo
country: United States
facility: University at Buffalo
state: New York
Study officials:
affiliation: University at Buffalo
name: Jennifer L Temple, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Temple JL, Bulkley AM, Badawy RL, Krause N, McCann S, Epstein LH. Differential effects of daily snack food intake on the reinforcing value of food in obese and nonobese women. Am J Clin Nutr. 2009 Aug;90(2):304-13. doi: 10.3945/ajcn.2008.27283. Epub 2009 May 20.
Clinical trial NCT05877794: Does the Central Venous Puncture Needle Need to be 7 cm?
Official title: Does the Central Venous Puncture Needle Need to be 7 cm? ; Safety and Usefulness of Needle Length Adjustment Method Using Suture Wing
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Central Venous Catheters
Lead sponsor: Ajou University School of Medicine
Sponsor class: OTHER
First posted: 2023-05-26
Enrollment: 20
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The central venous catheter (CVC) has been used for the first time in clinical use in 1921 and has been used worldwide by 2023. Although there are differences between studies, it is reported that side effects occur in approximately 5-20% of patients undergoing CVC. Common side effects include hematoma, venous puncture, arterial puncture, and pneumothorax, and horner syndrome is also reported in 5% of cases. In particular, in the case of the internal jugular vein (IJV), the possibility of puncture of the internal carotid artery is higher than that of other sites, and the puncture level also varies depending on the depth of needle insertion, which in some cases can cause very serious side effects. The incidence rate of side effects depends on the method of inserting the CVC and the skill of the operator. Previous method approached the IJV using the anatomy ladmark with the blind Seldinger technique, recently, as the use of ultrasound has become more common.

Ultra sound guided CVC insertion tecnique reduce the incidence of side effect. However, there are still major complications exist because less experiance operator inserts needle too deep without caution and only depends on the image of sonography.

Currently, the length of the needle commonly used in the CVC catheter set is 7 cm. In general, the depth from the skin to the IJV is within 1.5cm on either the right or the left, and under the premise that the needle insertion angle is 45 degrees, the distance from the skin to the IJV is within 2cm. Based on this, in previous studies, it was announced that the length of the needle required for IJV access was less than 4 cm.

The purpose of this study is to study the usefulness and safety of the method of sono-guided CVC catheter insertion by fixing the needle at a position 4 cm from the needle tip by placing the suture wing (18G, single catheter set).


Eligibility criteria: Inclusion Criteria:

* Adult patients who need CVC catheter for operation

Exclusion Criteria:

* Obesity (BMI \> 35)
* wound or infection exist at the puncture site
* History of long term catheter placment in the IJV
* Abnormally small size or deformity of the IJV
* Past history of difiiculty in CVC catheterization

  * If the IJV is located at a depth of 3cm or more from theskin on ultrasound evaluation

Primary outcomes:
measure: The difficulty of catheterization
timeFrame: through study completion, an average of 10 minutes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: