Clinical trial NCT00757614: Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom
Official title: A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Bladder Cancer
Brain and Central Nervous System Tumors
Esophageal Cancer
Intraocular Melanoma
Kidney Cancer
Lymphoma
Melanoma (Skin)
Pancreatic Cancer
Transitional Cell Cancer of the Renal Pelvis and Ureter
Keywords: AIDS-related lymphoma
cutaneous lymphoma
adult Hodgkin lymphoma
adult non-Hodgkin lymphoma
intraocular lymphoma
adult T-cell leukemia/lymphoma
primary central nervous system non-Hodgkin lymphoma
primary central nervous system Hodgkin lymphoma
noncutaneous extranodal lymphoma
adult astrocytic tumors
adult brain stem glioma
adult choroid plexus tumor
adult craniopharyngioma
adult embryonal tumor
adult ependymal tumors
adult meningeal tumor
adult oligodendroglial tumors
adult pineal parenchymal tumor
adult brain tumor
intraocular melanoma
bladder cancer
clear cell sarcoma of the kidney
congenital mesoblastic nephroma
esophageal cancer
melanoma
pancreatic cancer
peripheral primitive neuroectodermal tumor of the kidney
renal cell carcinoma
rhabdoid tumor of the kidney
transitional cell cancer of the renal pelvis and ureter
Lead sponsor: National Cancer Institute (NCI)
Sponsor class: NIH
First posted: 2008-09-23
Enrollment: 14000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 69
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with cancer in East Anglia, Trent, or West Midlands of the United Kingdom.

Detailed description: OBJECTIVES:

* To obtain epidemiological information and biological material on a population-based series of cancer cases, including malignant melanoma, lymphoma, bladder, kidney, esophageal, and pancreatic cancer, and brain tumors.
* Identify novel cancer susceptibility genes, by comparison of genotype frequencies in cases with the corresponding frequencies in large control series.
* To estimate the age and sex-specific risks associated with variants in predisposition genes.
* To evaluate interactions between polymorphisms in predisposition genes and potential lifestyle risk factors.

OUTLINE: This is a multicenter study.

Patients complete a detailed epidemiological questionnaire that includes information on education, occupation, smoking habits, alcohol consumption, height, weight, reproductive history (age at menarche, age at pregnancies, parity, and age at menopause), oral contraceptive use, hormone replacement therapy use, family history of cancer, and past medical history.

Blood samples are collected from patients. DNA is extracted from these blood samples, from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population-based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.

In addition to the cancer patients recruited for this study, patients with breast, ovarian, endometrial, colorectal, and prostate cancer are recruited for the following related clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL, and MREC-SEARCH-PROSTATE.

Eligibility criteria: DISEASE CHARACTERISTICS:

* Diagnosed with bladder cancer, kidney cancer, esophageal cancer, pancreatic cancer, brain cancer, malignant melanoma, or lymphoma within the past 5 years
* Identified through the Cancer Research Network OR through the cancer registry serving any of the following geographic regions of the United Kingdom:

  * East Anglia
  * West Midlands
  * Trent

PATIENT CHARACTERISTICS:

* Identified by the patient's general practitioner as fit to contact for this study
* No serious mental illness or retardation

PRIOR CONCURRENT THERAPY:

* Not specified

Primary outcomes:
measure: Acquisition of epidemiological information and biological material
measure: Identification of novel cancer susceptibility genes
measure: Estimation of the age and sex-specific risks associated with variants in predisposition genes
measure: Evaluation of interactions between polymorphisms in predisposition genes and potential lifestyle risk factors
Secondary outcomes:
Other outcomes:
Locations:
city: Cambridge
country: United Kingdom
facility: University of Cambridge Cancer Research UK
state: England
Study officials:
affiliation: Cancer Research UK
name: Paul Pharoah, MD
role: STUDY_CHAIR
References: