Clinical trial NCT06181123: Cardiopulmonary Assesments in Mood Disorders
Official title: Comparison of Functionality, Physical Activity, Cardiac and Respiratory Parameters Between Patients With Mood Disorders and Healthy Controls
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mood Disorders
Physical Inactivity
Respiratory Function Impaired
Lead sponsor: Mustafa Kemal University
Sponsor class: OTHER
Collaborators: name: The Scientific and Technological Research Council of Turkey
First posted: 2023-12-26
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: * being over 18 years of age
* being diagnosed with mood disorders

Brief summary: The importance of cardiorespiratory impact in mental diseases is generally emphasized in studies, but it is noteworthy that cardiorespiratory affects in mood disorders have not been sufficiently investigated. This study aims to compare individuals with mood disorders and healthy people in terms of exercise capacity, functionality, respiratory muscle strength, respiratory functions, dyspnea and physical activity level.

Detailed description: The cross-sectional study was carried out with 30 patients with diagnosis of mood disorder who applied to the Hatay Mustafa Kemal University Research and Practice Hospital, Mental Health and Diseases clinic, and 35 healthy individuals whose age, gender were matched. Clinical characteristics, exercise capacity (6-minute walking test, 6MWT; 3-minute Step test, 3MST), functionality (vertical jump test, functional reach test), respiratory parameters (Respiratory muscle strength, pulmonary function test), dyspnea (Modified Medical Research Council, MMRC scale), physical activity level (short form international physical activity questionnaire, IPAQ) was evaluated.

Eligibility criteria: Inclusion Criteria:

* Healthy volunteers who had undergone a general physical examination in the past 6 month
* reported being free of significant cardiovascular, respiratory, neuromuscular, and endocrine disorders that preclude safe participation

Exclusion Criteria:

* Individuals with significant cardiovascular, neuromuscular and endocrine disorders,
* pregnant women,
* people under 18 years old
* disabled individuals.

Primary outcomes:
measure: Six minute walking test (Evaluation of exercise capacity)
timeFrame: Baseline
measure: 3 minute step test (Assessment of exercise capacity)
timeFrame: Baseline
Secondary outcomes:
measure: Vertical jump test (Functionality 1)
timeFrame: in a time through the study completion, an average of 5 minutes
measure: Forced vital capacity (FVC) (Pulmonary function)
timeFrame: Baseline
measure: forced expiratory volume in the first second (FEV1) (Pulmonary function)
timeFrame: Baseline
measure: ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC)
timeFrame: Baseline
measure: peak expiratory flow rate (PEF)
timeFrame: Baseline
measure: forced mid-expiratory flow rate (FEF25-75%)
timeFrame: Baseline
measure: Respiratory muscle strenght
timeFrame: Baseline
measure: Physical activity
timeFrame: Baseline
measure: The Functional Reaching Test (Functionality 2)
timeFrame: Baseline
Other outcomes:
Locations:
city: Hatay
country: Turkey
facility: Hatay Mustafa Kemal University
state: Merkez
Study officials:
affiliation: Mustafa Kemal University
name: İrem Görgün, student
role: STUDY_DIRECTOR
References: