Clinical trial NCT03404427: Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study
Official title: Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sleep Deprivation
Healthy Volunteers
Skeletal Muscle
Lead sponsor: Poitiers University Hospital
Sponsor class: OTHER
First posted: 2018-01-19
Enrollment: 21
Sex: MALE
Minimum age (years): 25
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: To compare the motor endurance of healthy subjects after a normal sleep night and after a sleepless night.
Primary purpose: BASIC_SCIENCE

Brief summary: The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive.

During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force.

The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects.

Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control.

Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night.

Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.


Eligibility criteria: Inclusion Criteria:

* adult male volunteers;
* 25 to 45 years old
* regularly sleeping more than 6 hours per night;
* no excessive consumers of coffee (\<3 espressos / day);
* absence of muscular or neurological pathology ;
* with a BMI\> 18 and \<25 kg / m²;
* Horne and Ostberg score\> 31 and \<69 ;

Exclusion Criteria:

* female sex
* history of neuromuscular disease ;
* implanted metallic or electronic equipment (vascular stent, ocular implant, pacemaker ...)
* history of epilepsy, or discomfort after sleep deprivation ;
* poor sleepers (PSQI\> 5);
* exercising an activity in staggered hours;
* regularly performing more than 2 nights without sleep per month;
* taking drugs interfering with sleep (antidepressants, benzodiazepines ...);
* having crossed 4 time zones in the previous 4 weeks.
* current participation in another clinical research study;

Primary outcomes:
measure: Test duration
timeFrame: 1 hour.
Secondary outcomes:
Other outcomes:
Locations:
city: Poitiers
country: France
facility: Centre Hospitalier de Poitiers
state: Vienne
Study officials:
affiliation: Poitiers University Hospital
name: Xavier Drouot
role: PRINCIPAL_INVESTIGATOR
References: