louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00846573: Hyperpolarized Noble Gas MR Imaging for Pulmonary Disorders
Official title: Hyperpolarized Noble Gas MR Imaging for Pulmonary Disorders
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: COPD
Cystic Fibrosis
Asthma
Healthy
Keywords: Helium
MRI
Hyperpolarized Helium
Hyperpolarized Noble Gas
Lead sponsor: University of Massachusetts, Worcester
Sponsor class: OTHER
First posted: 2009-02-18
Enrollment: 14
Sex: ALL
Minimum age (years): 5
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to test the efficacy of Hyperpolarized Helium-3 gas in MR imaging in COPD, asthmatics, CF and healthy volunteers.

Detailed description: Current pulmonary imaging techniques are clinically regulated to machines that produce radiation. MR which does not produce radiation was not possible due to the low concentration of fluids in the open spaces of the lungs. With hyperpolarized noble gases we can now use the safe techniques of MR imaging to view the airways of the lungs, thus limiting human exposure to radiation. This technique has already been proven to be possible in human subjects but there is insufficient data show its efficacy in a clinical setting. This study is designed to image a variety of pulmonary disorders to better find possible clinical uses for hyperpolarized gas MRI.

Eligibility criteria: Inclusion Criteria:

* Are male or female and are 5 years or older
* Consent/assent from the patient
* Have been diagnosed with a pulmonary disease such as COPD, Asthma, or cystic fibrosis. OR Healthy Individuals.
* Must be able to hold their breath for up to 15 seconds

Exclusion Criteria:

* Have any contraindications to an MR exam such as a pace-maker, metallic cardiac valves, magnetic material (i.e., surgical clips) implanted electronic infusion pumps or any other conditions that would preclude proximity to a strong magnetic field;
* Are undergoing the MR exam in an emergency situation
* Are pregnant or become pregnant at any point within the study time.
* People with psychiatric disorders will be excluded from the study.
* Are claustrophobic and can not tolerate the imaging.
* Uses supplemental oxygen

Primary outcomes:
measure: Hyperpolarized Helium-3 MR Images
timeFrame: 15 second breath-hold
Secondary outcomes:
Other outcomes:
Locations:
city: Worcester
country: United States
facility: UMASS Medical School Advanced MRI Center United States
state: Massachusetts
Study officials:
affiliation: UMASS Medical School
name: Mitchell S Albert, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00078273: Indicated Prevention With At-Risk Gamblers
Official title: Indicated Prevention With At-Risk Gamblers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Gambling
Pathological Gambling
Problem Gambling
Keywords: Gambling
Pathological Gambling
Problem Gambling
College Students
Prevention
Lead sponsor: University of Washington
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2004-02-24
Enrollment: 225
Sex: ALL
Minimum age (years): 17
Maximum age (years): 24
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The overall purpose of this study is to reduce the prevalence of gambling risk in college students by evaluating the effectiveness of different treatments in reducing gambling behavior and related negative consequences.

Detailed description: Participants in this study will be randomly assigned to a personal feedback intervention (PFI) or assessment only for 3 years. The PFI intervention will be delivered in a single session. Measures will include the NORC DSM Screen for Problem Gambling (NODS), the South Oaks Gambling Screen (SOGS), Gambling Quantity and Perceived Norms, Perceived Injunctive Gambling Norms, Gambling Problems Index, gambling frequency, attitudes and beliefs about gambling and self-control, readiness to change, gambling expectancies, gambling motives, gambling risk perception, psychiatric symptoms, assertiveness, coping skills, substance use, alcohol-related problems, self-determination, and social desirability.

Eligibility criteria: Inclusion Criteria:

* College student
* South Oaks Gambling Screen (SOGS) score greater than 3

Exclusion Criteria:

* None, other than not meeting inclusion criteria

Primary outcomes:
measure: South Oaks Gambling Screen (SOGS)
timeFrame: 6-Months
measure: Gambling Quantity and Perceived Norms Scale (GQPN)
timeFrame: 6 Months
measure: Gambling Frequency (SOGS)
timeFrame: 6 Months
measure: Gambling Problems Index (GPI)
timeFrame: 6 Months
measure: National Opinion Research Center DSM-IV Screen for Pathological Gambling (NODS)
timeFrame: 6 Months
Secondary outcomes:
measure: Illusions of Control
timeFrame: 6 Months
Other outcomes:
Locations:
city: Seattle
country: United States
facility: University of Washington; Department of Psychiatry and Behavioral Sciences
state: Washington
Study officials:
affiliation: University of Washington, Dept of Psychiatry & Behavioral Sciences
name: Mary E Larimer, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Larimer ME, Neighbors C, Lostutter TW, Whiteside U, Cronce JM, Kaysen D, Walker DD. Brief motivational feedback and cognitive behavioral interventions for prevention of disordered gambling: a randomized clinical trial. Addiction. 2012 Jun;107(6):1148-58. doi: 10.1111/j.1360-0443.2011.03776.x. Epub 2012 Feb 28.
Clinical trial NCT03343873: The Effects of Different Anesthetics on Functional Connectivity
Official title: The Effects of Different Anesthetics on Functional Connectivity in Volunteers and Patients With Brain Tumor (ACTION)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Sedation
Keywords: anesthetics; fMRI; functional connectivity
Lead sponsor: Beijing Tiantan Hospital
Sponsor class: OTHER
First posted: 2017-11-17
Enrollment: 240
Sex: MALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: This research is a prospective cohort study. The aim of the study is to determine different levels of sedative mechanism and the effect on brain functional connectivity of midazolam, dexmedetomidine and propofol.

Detailed description: This research will include 120 healthy volunteers and 120 brain tumor patients; the participants will be allocated into midazolam, dexmedetomidine and propofol group. Resting and task fMRI will be performed at awake (BIS\>90), mild sedation (BIS 80-85), moderate sedation (BIS 65-75), deep sedation (BIS 45-55) and recovery states (BIS \>90). The primary outcome of our study is the effect of different levels of sedation for brain network connection. The secondary outcomes are the effect of different levels of sedation for default, executive control, sensory and motor networks and their subnetwork connectivity; the sedation state, circulatory and respiratory parameters of the participants, and the adverse events.

Eligibility criteria: Inclusion Criteria:

* 1. Male, 18 \~ 65 years old
* 2. Healthy Volunteer / Brain Tumor Patients
* 3. Senior high school and above
* 4. Sign informed consent

Exclusion Criteria:

* 1. In vivo implant MRI check taboo
* 2. Cardiopulmonary liver and kidney and other systemic complications
* 3. History of major surgical anesthesia
* 4. Abuse of drugs, alcoholism history
* 5. Test drug allergy history
* 6. Claustrophobia
* 7. Left hand

Primary outcomes:
measure: Amplitude of Low Frequency Fluctuations（ALLF）and Regional Homogeneity（ReHo)
timeFrame: 30mins after administration
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Tian Tan Hospital
Study officials:
affiliation: Department of Anesthesiology, Beijing Tiantan Hospital
name: Ruquan Han, M.D., Ph.D
role: STUDY_CHAIR
References:
Clinical trial NCT03471273: Comparison of Endoscopic and Laparoscopic Resection for Small Gastric Gastrointestinal Stromal Tumor
Official title: Comparison of Endoscopic and Laparoscopic Resection for Small Gastric
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Therapeutic Value of Endoscopic and Laparoscopic Resection for Small Gastric Gastrointestinal Stromal Tumor
Lead sponsor: Nanfang Hospital, Southern Medical University
Sponsor class: OTHER
Collaborators: name: Shenzhen Hospital of Southern Medical University
First posted: 2018-03-20
Enrollment: 900
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparison of Endoscopic and Laparoscopic Resection for Small Gastric Gastrointestinal Stromal Tumor


Eligibility criteria: Inclusion Criteria:

* 18-70 years old Chinese;
* Definite diagnosis or endoscopic ultrasonography, CT and other highly suspected Chinese patients with gastric stromal tumors;
* Patients voluntarily signed informed consent and have been orally informed of the specific trial plan.

Exclusion Criteria:

* Patients with gastric stromal tumors with distant metastasis who cannot be treated by laparoscopic surgery;
* Combined heart , cerebrovascular , liver , kidney , and hematopoietic system serious primary disease;
* gastric stromal tumors with severe digestive tract hemorrhage endanger the immediate surgical treatment of life;
* The investigator considers that it is not suitable for this test.

Primary outcomes:
measure: recur or not in 2 years after endoscopic surgical procedure or surgery
timeFrame: 2 years after endoscopic surgical procedure or surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Nanfang Hospistal
state: Guangdong
Study officials:
References:
Clinical trial NCT04980573: Essential Oils and Post COVID-19 Fatigue
Official title: The Effects of Aromatherapy on Post COVID-19 Fatigue: A Randomized, Double Blind, Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Covid19
Fatigue
Keywords: essential oils
aromatherapy
energy
Lead sponsor: Nutraceuticals Research Institute
Sponsor class: OTHER
Collaborators: name: Young Living Essential Oils
First posted: 2021-07-28
Enrollment: 47
Sex: ALL
Minimum age (years): 19
Maximum age (years): 49
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to assess the efficacy of plant based aromas on energy levels among otherwise healthy female survivors of COVID-19.

Detailed description: After being informed about the study, participants will provide informed consent, then will be randomized into one of two groups in a 1:1 ratio. Participants will either inhale an inert blend twice a day or an active aroma twice a day for 14 days.

Eligibility criteria: Inclusion Criteria:

* Age 19-49
* Lives in the United States
* Otherwise Healthy
* COVID-19 Diagnosis between December 1, 2020 and March 31, 2021
* Decreased energy or fatigue at a level that was not present prior to the diagnosis

Exclusion Criteria:

* Positive COVID-19 test any time before December 1, 2020
* Positive COVID-19 test any time after March 31, 2021
* COVID vaccine of any type scheduled during the intervention period or the week prior to the start of the study
* Allergy to any of the ingredients
* Pregnant, trying to conceive, or breastfeeding
* Regular smokers in the home
* Abnormal pulmonary function
* Chest pain
* Recurring headaches
* Uncontrolled hypertension
* Chronic Fatigue Syndrome diagnosis
* Persistent fatigue prior to COVID-19 diagnosis
* Hypothyroidism

Primary outcomes:
measure: Change from baseline on the Multidimensional Fatigue Symptom Inventory (MFSI) at day 14.
timeFrame: Baseline and Day 14
Secondary outcomes:
measure: Change from baseline to day 14 on the Patient Health Questionnaire (PHQ-9)
timeFrame: Baseline and Day 14
Other outcomes:
Locations:
city: Franklin
country: United States
facility: Franklin Health Research Center
state: Tennessee
Study officials:
References:
Clinical trial NCT05608473: The Effects of Video Based Cervical and Thoracal Posture Exercises on Office Workers
Official title: The Effects of Video Based Cervical and Thoracal Posture Exercises on Head and Neck Posture, Muscular Endurance and Quality of Life in Office Workers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physical Inactivity
Quality of Life
Keywords: Exercise
Posture
Workers
Lead sponsor: Dokuz Eylul University
Sponsor class: OTHER
Collaborators: name: Dokuz Eylul University
First posted: 2022-11-08
Enrollment: 60
Sex: ALL
Minimum age (years): 25
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Aim of this study was investigate the effects of video-based cervical and thoracic postural exercises on muscle strength and endurance, hand grip strength, head-neck posture, quality of life and patient satisfaction in office workers.

Detailed description: 60 office workers between the ages of 25-65 were included in the study. Participants were randomly divided into Exercise group (EG, n=30) and Control group (KG, n=30). The video-based postural exercises were uploaded to the computers of the EG participants. They were asked to perform the exercises simultaneously with the video, 3 days a week for a total of 6 weeks. The control group was given one session of training on postural exercises. Cervical and scapular muscle strength and endurance, grip strength, craniovertebral angle, muscle endurance and strength, grip strength and head-neck posture measurements were made before the study and at the end of the 6th week. In addition, quality of life and satisfaction were evaluated with questionnaires.

Eligibility criteria: Inclusion Criteria:

* To be an office worker for at least 3 years
* To be literate

Exclusion Criteria:

* History of cervical, thoracic or shoulder surgeries
* Exercising regularly for the last 6 months

Primary outcomes:
measure: Head-Neck Posture
timeFrame: Baseline
measure: Head-Neck Posture
timeFrame: At the end of the 6th week
measure: Muscle Strength
timeFrame: Baseline
measure: Muscle Strength
timeFrame: At the end of the 6th week
measure: Muscle Endurance
timeFrame: Baseline
measure: Muscle Endurance
timeFrame: At the end of the 6th week
measure: Handgrip Strength
timeFrame: Baseline
measure: Handgrip Strength
timeFrame: At the end of the 6th week
Secondary outcomes:
measure: General Health
timeFrame: Baseline
measure: General Health
timeFrame: At the end of the 6th week
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: Dokuz Eylul University
Study officials:
affiliation: Dokuz Eylul University
name: Nihal GELECEK, Professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT02778373: Comparative Effects of Post-exercise Ingestion of a High or Low Molecular Weight Solution on Resistance Exercise Performance
Official title: Comparative Effects of Post-exercise Ingestion of a High or Low Molecular Weight Solution on Resistance Exercise Performance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Task Performance and Analysis
Lead sponsor: Texas Christian University
Sponsor class: OTHER
First posted: 2016-05-19
Enrollment: 30
Sex: MALE
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: This study sought to examine differences in resistance exercise performance, as measured by the kinetic and kinematic profile during multiple sets of the back squat exercise, following ingestion of high or low molecular weight carbohydrate beverages.


Eligibility criteria: Inclusion Criteria:

* having at least 2 years resistance training experience to include the parallel back squat exercise at least once a week
* no musculoskeletal injury within previous 1 year
* not having consumed any nutritional or ergogenic supplement excluding protein and/or a daily vitamin for the previous 6-week period

Exclusion Criteria:

* no previous resistance training experience
* musculoskeletal injury within the previous 1 year
* having consumed or presenting consuming a nutritional or ergogenic supplement

Primary outcomes:
measure: Change in Power Output
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Piehl Aulin K, Soderlund K, Hultman E. Muscle glycogen resynthesis rate in humans after supplementation of drinks containing carbohydrates with low and high molecular masses. Eur J Appl Physiol. 2000 Mar;81(4):346-51. doi: 10.1007/s004210050053.
citation: Leiper JB, Aulin KP, Soderlund K. Improved gastric emptying rate in humans of a unique glucose polymer with gel-forming properties. Scand J Gastroenterol. 2000 Nov;35(11):1143-9. doi: 10.1080/003655200750056600.
citation: Stephens FB, Roig M, Armstrong G, Greenhaff PL. Post-exercise ingestion of a unique, high molecular weight glucose polymer solution improves performance during a subsequent bout of cycling exercise. J Sports Sci. 2008 Jan 15;26(2):149-54. doi: 10.1080/02640410701361548.
citation: Oliver JM, Almada AL, Van Eck LE, Shah M, Mitchell JB, Jones MT, Jagim AR, Rowlands DS. Ingestion of High Molecular Weight Carbohydrate Enhances Subsequent Repeated Maximal Power: A Randomized Controlled Trial. PLoS One. 2016 Sep 16;11(9):e0163009. doi: 10.1371/journal.pone.0163009. eCollection 2016.
Clinical trial NCT00368173: IGF-I/IGFBP-3 Therapy in Children and Adolescents With Growth Hormone Insenitivity Syndrome (GHIS) Such as Laron Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Growth Hormone Insensitivity Syndrome (GHIS)
Laron Syndrome
Lead sponsor: Insmed Incorporated
Sponsor class: INDUSTRY
First posted: 2006-08-24
Sex: ALL
Minimum age (years): 2
Maximum age (years): 18
Standard ages: CHILD
ADULT
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: STUDY OBJECTIVE

To evaluate the safety, tolerability, and efficacy, as growth velocity (statural growth), of rhIGF-I/rhIGFBP-3 administered for 12 months in pre-pubertal children and adolescents with GHIS.

STUDY DESIGN

This study is an open-label, multi-center clinical trial to evaluate the safety and effectiveness of rhIGF-I/rhIGFBP-3 to increase rate of growth when administered once daily for 12 months in children and adolescents with growth hormone insensitivity syndrome (GHIS) such as Laron Syndrome. At the end of the initial twelve-month treatment period, additional safety and long-term efficacy data will be assessed in a second 12 month treatment period.


Eligibility criteria: Inclusion Criteria:

1. A diagnosis of GHIS such as Laron syndrome,
2. 2 - 18 years of age,
3. Height less than or equal to -3SD for age,
4. Pre-pubertal, defined as Tanner breast stage 1 or testis volume \<4mL

Exclusion Criteria:

1. Children in puberty,
2. Diagnosed malignancy,
3. A diagnosis of diabetes mellitus

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Robert Rapaport, MD
state: New York
city: Buenos Aires
country: Argentina
facility: Dr. Alicia Belgorosky
city: Tucuman
country: Argentina
facility: Dr. Christina Bazan
city: Newcastle
country: Australia
facility: Dr. Bruce King
city: Sao Paulo
country: Brazil
facility: Dr. Durval Damiani
city: Hong Kong
country: China
facility: Dr. Kwok-leung NG
city: Cairo
country: Egypt
facility: Dr. Mohamed EL Kholy
city: Berlin
country: Germany
facility: Professor Annette Greuters
city: Haifa
country: Israel
facility: Tiosano Dov
city: Naples
country: Italy
facility: Maria Carolina Salerno
city: Oslo
country: Norway
facility: Dr. Hilde Bjorndalen
city: Lima
country: Peru
facility: Dr. Carlos del Aguila
city: Kosice
country: Slovakia
facility: Dr. Magdalena Paskova
city: Ankara
country: Turkey
facility: Professor Nursen Yordam
city: London
country: United Kingdom
facility: Dr. Cecilia Camacho-Hubner
Study officials:
References:
Clinical trial NCT02923973: Transvaginal Ultrasound Cervical Length Screening in Singleton Pregnancy With Prior Spontaneous Preterm Birth
Official title: Transvaginal Ultrasound Cervical Length Screening in Singleton Pregnancy With Prior Spontaneous Preterm Birth
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Preterm Birth
Lead sponsor: Federico II University
Sponsor class: OTHER
Collaborators: name: University of Pisa - Prof Paolo Mannella
First posted: 2016-10-05
Enrollment: 500
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Preterm birth (PTB) is the major cause of perinatal morbidity and mortality. Worldwide, about 15 million babies are born too soon every year, causing 1.1 million deaths, as well as short- and long-term disability in countless survivors. Few prognostic tests are available to predict PTB. A short transvaginal ultrasound cervical length (TVU CL) has been shown to be a good predictor of PTB.Different strategies have been adopted for prevention of PTB. The evidence supports the use of vaginal progesterone in singleton pregnancies with short cervix, while cervical cerclage seems to be beneficial only in the subgroup of singleton gestations with both prior spontaneous PTB and TVU CL ≤25mm, and not in singletons without prior PTB, nor in multiple gestations.

However, so far there are no level-1 data on the efficacy of TVU CL screening neither in low risk nor in high risk pregnancy Thus, the investigators aim to assess the efficacy of a policy of TVU CL screening in singleton pregnancy with prior spontaneous PTB


Eligibility criteria: Inclusion Criteria:

* 18-50 years of age
* Singleton gestations
* Women with prior spontaneous preterm birth, defined as spontaneous preterm delivery 16 0/7 - 36 6/7 weeks

Exclusion Criteria:

* multiple gestation
* Ruptured membranes or fetal structural or chromosomal abnormality at the time of randomization
* Ballooning of membranes outside the cervix into the vagina at the time of randomization
* Labor or cerclage in situ at the time of randomization

Primary outcomes:
measure: Preterm delivery
timeFrame: Less than 37 weeks gestation
Secondary outcomes:
measure: Gestational age at delivery
timeFrame: Time of delivery
measure: preterm birth rates
timeFrame: Less than 24, 28, 34 weeks gestation
measure: Birth weight
timeFrame: Time of delivery
measure: Low birth weight
timeFrame: Time of delivery
measure: Neonatal death
timeFrame: Between birth and 28 days of age
measure: Composite adverse neonatal outcome
timeFrame: Between birth and 28 days of age
measure: Admission to neonatal intensive care unit
timeFrame: Between birth and 28 days of age
Other outcomes:
Locations:
city: Naples
country: Italy
facility: Gabriele Saccone
city: Pisa
country: Italy
facility: University of Pisa
Study officials:
References: