louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06445660: The Feasibility of a Radiological Score Based on CT Signs for Recognizing Salvageable Bowel in Acute Mesenteric Ischemia
Official title: The Feasibility of a Radiological Score Based on Quantified Analysis of Computed Tomography Signs for Recognizing Salvageable Bowel in Acute Mesenteric Ischemia: A Retrospective Analysis of Prospective Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Acute Mesenteric Ischemia
Lead sponsor: University of Tartu
Sponsor class: OTHER
First posted: 2024-06-06
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This is a substudy of the AMESI study - "Incidence, Diagnosis, Management, and Outcome of Acute Mesenteric Ischaemia: A Prospective, Multicentre Observational Study." (Clinical Trials: NCT05218863) As of the end of August 2023, a total of 705 patients from 32 study sites worldwide have been enrolled, with 418 of them having confirmed cases of AMI. For patients with confirmed AMI, comprehensive data collection concerning diagnostics, management, and long-term outcomes has been completed

Brief summary: Computed tomography (CT) is the standard modality for scanning patients with critical acute abdominal conditions, including suspected acute mesenteric ischemia (AMI). CT imaging can potentially differentiate between reversible and irreversible ischaemic damage of the bowel. This moment is pivotal in selecting the treatment strategy for AMI - in the absence of irreversible damage; reperfusion therapy can preserve intestinal viability, thereby avoiding the need for bowel resection. The present study tests the hypothesis that combining several symptoms may enhance the diagnostic performance of CT scanning in detecting salvageable bowel in patients with AMI. This study is an ancillary component of the AMESI study (Clinical Trials: NCT05218863) - a prospective, multicentre observational study aimed at identifying the incidence and describing the outcomes of acute mesenteric ischemia (AMI) in adult hospitalized patients. The ultimate purpose of the present study is to create a computed tomography-based radiological score for the assessment of bowel viability in patients with AMI.


Eligibility criteria: Inclusion Criteria:

* Participant in AMESI study
* confirmed or suspected acute mesenteric ischaemia
* CT scan of the entire abdominal cavity / full body using intravenous contrast media is available

Exclusion Criteria:

* Scans without the use of an intravenous contrast media or those covering only a partial area of the abdomen will be excluded.

Primary outcomes:
measure: Frequency rate
timeFrame: up to one month
Secondary outcomes:
measure: Performance of the radiological score
timeFrame: up to one month
Other outcomes:
Locations:
city: Tartu
country: Estonia
facility: Tartu University Hospital
Study officials:
affiliation: University of Tartu, Department of Anaesthesiology and Intensive Care
name: Joel Starkopf
role: STUDY_CHAIR
References:
Clinical trial NCT03655860: Effects of SIMEOX on Flow and Volume
Official title: Evaluation of SIMEOX on Flow and Volume Elicited in Healthy Subjects
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Healthy
Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2018-08-31
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study will investigate the effects of the SIMEOX (an airway clearance device) on flow and volume generated in healthy subjects

Detailed description: This is a pilot study assessing the effect of the SIMEOX device on flow and volume generated in healthy subjects.

Assessment of flow and volume will be performed before and during the application of the SIMEOX. Vital capacity and expiratory flow will be assessed.

Eligibility criteria: Inclusion Criteria:

* Able to understand the instructions

Exclusion Criteria:

* Obesity (BMI \> 30kg/m²)
* Active smoker
* Severe scoliosis
* Cardiovascular ou neuromuscular disease

Primary outcomes:
measure: Change in expiratory volume
timeFrame: 5min
measure: Change in expiratory volume flow rate
timeFrame: 5min
Secondary outcomes:
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: William Poncin
Study officials:
affiliation: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
name: Grégory Reychler, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01025960: A Comparison of Methods to Detect Polyps During Colonoscopy
Official title: Comparison of Detection of Polyps During Both Insertion and Withdrawal Phases of Colonoscopy Versus the Standard Practice of Detection of Polyps During the Withdrawal Phase of Colonoscopy: A Prospective Quality Improvement Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colorectal Cancer
Keywords: colonoscopy
adenoma detection
polyps
Lead sponsor: The Cleveland Clinic
Sponsor class: OTHER
First posted: 2009-12-04
Enrollment: 768
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer deaths in western countries. Colonoscopy is a preferred colorectal screening modality since it has both diagnostic and therapeutic capability. Detection and removal of polyps at colonoscopy decreases the incidence and mortality from colorectal cancer.

Typical practice is to insert the colonoscope rapidly until it reaches the cecum (a pouch-like portion of the intestines, where the large bowel and the small bowel meet). The physician then withdraws the colonoscope slowly and looks for any polyps or abnormalities within the large bowel. The purpose of this study is to compare this standard practice to the approach whereby the physician examines the bowel as the scope is initially inserted AND as the colonoscope is withdrawn from patients' colons.


Eligibility criteria: Inclusion Criteria:

* Adult patients
* Patients able to provide an informed consent
* Patients undergoing colonoscopy

Exclusion Criteria:

* Pregnant women
* Patients with Familial Adenomatous Polyposis Syndromes (FAP)
* Patients with Hereditary Non-polyposis Colon Cancer Syndrome (HNPCC)
* Patients who have undergone previous surgical resection of the colon
* Patients who have been diagnosed with inflammatory bowel disease

Primary outcomes:
measure: Adenoma detection rates for each method
timeFrame: within the first 30 days after colonoscopy
Secondary outcomes:
measure: Comparison of procedure times for each method
timeFrame: 1 year
measure: Percentage of patients with at least one adenoma detected by each method
timeFrame: 1 year
measure: Comparison of percentage of adenomas classified as high risk for each method
timeFrame: 1 year
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
Study officials:
affiliation: The Cleveland Clinic
name: Madhusudhan Sanaka, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Sanaka MR, Parsi MA, Burke CA, Barnes D, Church J, Rizk M, Zein N, Joseph R, Thota PN, Lopez R, Kiran RP. Adenoma detection at colonoscopy by polypectomy in withdrawal only versus both insertion and withdrawal: a randomized controlled trial. Surg Endosc. 2015 Mar;29(3):692-9. doi: 10.1007/s00464-014-3723-3. Epub 2014 Jul 19.
Clinical trial NCT06562660: The Effect of Mask Combined With High Flow Oxygen on Preoxygenation During Induction of General Anesthesia in Obese Patients
Official title: The Effect of Mask Combined With High Flow Oxygen on Preoxygenation During Induction of General Anesthesia in Obese Patients
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Obese
Keywords: High-Flow Nasal Oxygen
Obese Men
Smoking
Lead sponsor: Henan Provincial People's Hospital
Sponsor class: OTHER
First posted: 2024-08-20
Enrollment: 60
Sex: MALE
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A total of 60 male obese patients undergoing elective non-thoracic surgery were divided into two groups (n=30) based on smoking status: smokers(S groups), and never smokers(NS groups). Those in the smoking group were current or past smokers, while those in the nonsmoking group had never smoked.
Primary purpose: PREVENTION

Brief summary: There is a risk of airway-related incidents during anaesthesia associated with obesity. High-flow nasal oxygen is advocated for perioperative preoxygenation in obese patients to reduce airway adverse reactions. However, there have been no reports on whether smoking behaviors have an impact on obese men's Apnoeic oxygenation with high-flow nasal.This study compared the effects of smoking on the duration of safe apnoea times in obese males.

Detailed description: All patients were were divided into two groups based on smoking status: smokers(S groups), and never smokers(NS groups). Those in the smoking group were current smokers, while those in the nonsmoking group had never smoked. Both groups of patients were induced with intravenous anesthesia and received 5 minutes of high flow nasal oxygen (60 L min) prior to induction.After induction of anaesthesia, the patients were apnoeic until peripheral oxygen saturation decreased to 95 %.

Eligibility criteria: Inclusion Criteria:

1. Participants ranged in age from 18 to 80 with BMI≥30 kg/m2.
2. Participants are male obese patients undergoing elective non-thoracic surgery

Exclusion Criteria :

1. patients were kept awake during the intubation due to cervical spine pathology.
2. Patients with unstable hemodynamics.
3. Patients with airway inflammatory diseases, including asthma, chronic obstructive pulmonary disease (COPD), lung cancer, pulmonary fibrosis and cystic fibrosis.
4. Patients with upper respiratory infection and nasal blockage.
5. Patients with Hypersensitivity to the drug.

Primary outcomes:
measure: the safe apnoea times
timeFrame: 5-minute
Secondary outcomes:
measure: the Pao2 levels
timeFrame: 5-minute
Other outcomes:
Locations:
city: Zhengzhou
country: China
facility: Wanghuabing
Study officials:
affiliation: Chief physician
name: jiaqiang zhang
role: STUDY_DIRECTOR
References:
Clinical trial NCT04292860: Reverse Axillary Mapping in Breast Radiation Treatment Planning
Official title: Reverse Axillary Mapping as a Lymphedema Prevention Strategy in Breast Radiation Treatment Planning
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Breast Cancer
Lymphedema
Keywords: Lymphedema
Axillary Reverse Mapping
Breast Cancer
Lead sponsor: UNC Lineberger Comprehensive Cancer Center
Sponsor class: OTHER
First posted: 2020-03-03
Enrollment: 0
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Post-operative (lumpectomy or mastectomy) female breast cancer patients who will receive radiation to the whole breast or chest wall and the regional nodes.

Brief summary: The goal of this prospective study is to investigate the role of axillary reverse mapping (ARM) in radiation therapy planning of patients with breast cancer. Lymphedema is a common side effect after surgery and radiation therapy for breast cancer. The use of ARM is becoming more routine in surgery to differentiate the upper extremity lymphatics (UELs) from the breast axillary drainage to preferentially spare the UELs and reduce the rates of lymphedema.


Eligibility criteria: Inclusion Criteria:

* De novo presentation of post-operative (lumpectomy or mastectomy) female breast cancer patients to receive radiation to the whole breast or chest wall and the regional nodes. Patients who have received a sentinel lymph node (SLN) biopsy or an axillary lymph node dissection (ALND) will be eligible.
* Greater than or equal to 18 years of age (no upper age limit).
* Informed consent obtained.

Exclusion Criteria:

* Prisoners.
* Patients with metastatic breast cancer.
* Documented allergy to iodinated contrast
* Prior breast or axillary surgeries or radiation.

Primary outcomes:
measure: Delineation of the upper extremity lymphatics (UEL) during the radiation treatment planning process using axillary reverse mapping (ARM)
timeFrame: Baseline to 1 year
Secondary outcomes:
measure: Dosimetric endpoint
timeFrame: Baseline to 1 year
measure: Lymphedema rate
timeFrame: Baseline to 5 years post-treatment
Other outcomes:
Locations:
Study officials:
affiliation: UNC Chapel Hill
name: Dana Casey
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03104660: Coronary and Structural Interventions Ulm - Transcatheter Mitral Valve Repair (CSI-Ulm-TMVR)
Official title: Coronary and Structural Interventions Ulm - Transcatheter Mitral Valve Repair (CSI-Ulm-TMVR)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mitral Valve Regurgitation
Lead sponsor: University of Ulm
Sponsor class: OTHER
First posted: 2017-04-07
Enrollment: 355
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: CE certified mitral valve repair systems
Primary purpose: TREATMENT

Brief summary: To evaluate the long-term results after transcatheter mitral valve repair

Detailed description: Patients with transcatheter mitral valve repair are followed for 10 years to demonstrate efficacy and safety.

Eligibility criteria: Inclusion Criteria:

* mitral valve regurgitation
* transcatheter mitral valve repair

Exclusion Criteria:

* no written informed consent

Primary outcomes:
measure: Major adverse cerebral and cardiac events
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Ulm
country: Germany
facility: University Hospital Ulm
Study officials:
affiliation: University Hospital Ulm
name: Jochen Woehrle, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Seeger J, Markovic S, Kessler M, Rottbauer W, Wohrle J. Apixaban After Percutaneous Edge-to-Edge Mitral Valve Repair in Patients With Maintained Sinus Rhythm. JACC Cardiovasc Interv. 2019 Jan 28;12(2):214-216. doi: 10.1016/j.jcin.2018.11.009. No abstract available.
citation: Seeger J, Muller P, Gonska B, Scharnbeck D, Markovic S, Walcher D, Rottbauer W, Wohrle J. Percutaneous Mitral Valve Repair With the MitraClip in Primary Compared With Secondary Mitral Valve Regurgitation Using the Mitral Valve Academic Research Consortium Criteria. J Invasive Cardiol. 2017 Apr;29(4):145-150.
Clinical trial NCT05585060: The Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients
Official title: The Relevance and Consistency Study of Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: COPD
Keywords: COPD
dynamic pulmonary hyperinflation
mechanical ventilation
end expiratory lung impedence
Lead sponsor: The First Affiliated Hospital of Guangzhou Medical University
Sponsor class: OTHER
First posted: 2022-10-18
Enrollment: 10
Sex: ALL
Minimum age (years): 35
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping, dynamic pulmonary hyperinflation (DPH), therefore the intrinsic PEEP (PEEPi) increases. It is worthwhile to explore bedside methods to quantify the changes in dynamic pulmonary hyperinflation to guide safe and effective mechanical ventilation in airflow limited patients.

Detailed description: The study hypothesizes that the electrical impedence tomography (EIT) measured the changes of end expiratory lung impedence (△EELI） could accurately predict the changes of end expiratory lung volume （△EELV） measured by passive expiratory in controlled mechanical ventilated exacerbation COPD patients. The research intended to conduct a research to explore the relationship between △EELI and △EELV induced by external PEEP changes in ventilated exacerbation COPD patients.

Eligibility criteria: Inclusion Criteria:

* 2022.7-2023.1 exacerbation COPD invasive ventilated patients admitted to the first affiliated Guangzhou medical university; 35 to 80 years old; in stable condition judged by clinicians

Exclusion Criteria:

* SpO2\<88%; instable hemodynamic (MAP\<65mmHg；Norepinephrine\> 0.1ug/kg.min); pregnancy; 4 hour intravenous diuretics use before research; chest deformity and trauma, subpleural pulmonary bulla; implanted electronic devices(cardiac pacemaker, implantable cardioversion defibrillator,ect); tumour or other organ dysfunction; refuse to signature the informed consent

Primary outcomes:
measure: the changes of end expiratory lung volume
timeFrame: 10 minutes
Secondary outcomes:
measure: intrinsic PEEP
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou Medical
state: Guangdong
Study officials:
affiliation: The First Affiliated Hospital of Guangzhou Medical University
name: Rongchang Chen, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT00950560: An Empirical Study of Perceived Hospital Service Quality: A Comparison of Inpatient, Outpatient and Emergence Patient
Official title: An Empirical Study of Perceived Hospital Service Quality: A Comparison of Inpatient, Outpatient and Emergence Patient
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Service Quality
Satisfaction
Lead sponsor: Taipei Medical University WanFang Hospital
Sponsor class: OTHER
First posted: 2009-08-03
Enrollment: 2
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: 100 inpatient 100 outpatient 100 emergency patient

Brief summary: The authors employ a questionary approach to understanding the relational among patients' perceptions of inpatient, outpatient and emergency room service and their overall perceptions of service quality, satisfaction with hospital.The questionary was applied in total 300 patients (100 inpatients, 100 outpatients and 100 emergency patients).


Eligibility criteria: Inclusion Criteria:

* Patients who want to write our questionary.

Exclusion Criteria:

* Patients who reject to write our questionary.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Municipal Wan Fang Hospital
Study officials:
affiliation: Taipei Medical University-Wan Fang Hospital
name: Hui-Chih Wang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02387060: Use of Intrathecal Fentanyl and Development of Hyperalgesia in Patients Undergoing Elective Cesarean
Official title: Use of Intrathecal Fentanyl and Development of Hyperalgesia in Patients Undergoing Elective Cesarean
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Complications; Cesarean Section
Keywords: Anesthesia
Spinal and Epidural
Adverse Effect
Complications
Lead sponsor: Pontificia Universidad Catolica de Chile
Sponsor class: OTHER
First posted: 2015-03-12
Enrollment: 80
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Opioid analgesic drugs are the main treatment of patients during anesthesia. Although highly effective, their use is not without problems. One is the increasing requirement of these address the same nociceptive stimulus.

Opioid induced hyperalgesia could be an explanation studies in animal models. Through mechanisms where N-methyl-D-aspartate receptors, glutamatergic system disturbances and changes in intracellular calcium regulation involved.

The hyperalgesia induced by intrathecal opioids is controversial. The investigators propose a model study in patients undergoing cesarean section to study the secondary hyperalgesia induced based on the study of nociceptive thresholds with two methods opioids: Von Frey filaments and digital algometer.

If intrathecal fentanyl is used in spinal anesthesia for elective cesarean section, then, an increase in sensitivity will occur. This increase can be measured by von Frey filaments, expressed in increased requirement clinically opioids.


Eligibility criteria: Inclusion Criteria:

* Pregnant 37 to 41 weeks.
* American Society of Anesthesiologists classificationI or II.
* Between 18 and 40 years.
* Scheduled for elective cesarean section under spinal anesthesia in the Maternity Service of the Clinical Hospital of the Catholic University.

Exclusion Criteria:

* Background Of high risk pregnancy. Twin-pregnancy.
* Obesity\> 30 kg / m 2 before pregnancy.
* Background Of psychiatric illness.
* Using Chronic analgesic.
* AllergyDrug used in protocol.
* require General anesthesia during surgery

Primary outcomes:
measure: Change in Punctate - Von frey (grams)
timeFrame: Change from Baseline in punctate sensibility at 48 hours
Secondary outcomes:
measure: Change in Pressure pain - algometer (kg/cm/cm)
timeFrame: Change from Baseline in pressure pain at 48 hours
Other outcomes:
Locations:
city: Santiago
country: Chile
facility: Hospital Clinico Pontificia Universidad Catolica
state: Región Metropolitana
Study officials:
affiliation: Ponticia Universidad Católica
name: Luis I Cortinez, MD
role: STUDY_CHAIR
References: