louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03232476: Effect of Mechanical Loading With PTH on Cortical Bone
Official title: Effect of Mechanical Loading With PTH on Cortical Bone
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Osteoporosis, Postmenopausal
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
First posted: 2017-07-28
Enrollment: 18
Sex: FEMALE
Minimum age (years): 45
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Clinical trial to investigate effect of voluntary upper extremity loading in combination with anabolic osteoporosis therapy.


Eligibility criteria: Inclusion Criteria:

* women aged 45+
* postmenopausal
* osteoporotic with high risk of fracture

Exclusion Criteria:

* no significant previous use of bone health modifying treatments

Primary outcomes:
measure: radius bone mineral density
timeFrame: 12 month change
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: MGH
name: Joy Tsai, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05650476: Pre-approval Single-patient Expanded Access for Talazoparib (PF-06944076)
Study type: EXPANDED_ACCESS
Overall status: AVAILABLE
Conditions: Metastatic Castration-Resistant Prostate Cancer
Keywords: Prostate Cancer
metastatic* Castration-Resistant Prostate Cancer (mCRPC)
enzalutamide
combination therapy
first-line mCRPC
metastatic (M1)
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2022-12-14
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT

Brief summary: Provide pre-approval single-patient Expanded Access (Compassionate Use) of talazoparib for patients with metastatic castration-resistant prostate cancer.

Detailed description: In Expanded Access, treating physicians are the Sponsors..

Expanded Access requests from treating physicians may be submitted at www.pfizercares.com; availability will depend on location/country.

Eligibility criteria: Talazoparib is not intended for monotherapy. Talazoparib is intended for combination use with enzalutamide in first-line metastatic (M1) Castration-Resistant Prostate Cancer (mCRPC) only. Must be a newly diagnosed mCRPC patient who has not yet received 1st line therapy (1st generation Androgen Receptor (AR)-inhibitors do not count). Must have not received 2nd generation AR-inhibitors (enzalutamide, apalutamide, darolutamide), a Poly \[ADP-ribose\] polymerase (PARP)-inhibitor, cyclophosphamide, or mitoxantrone as prior treatments in any prostate cancer disease setting. Previous abiraterone and/or docetaxel for hormone-sensitive disease (CSPC) is allowed (patient eligible). Patients with identified need for use of potent P-glycoprotein (P-gp) inducer drugs within 7 days of onset/under duration of talazoparib plus enzalutamide treatment are at risk of drug-drug interactions (DDIs) and are therefore ineligible. Additional eligibility criteria may be required.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03496376: Effects of Thoracic Kinesio Taping on COPD Patients
Official title: Effects of Thoracic Kinesio Taping on Pulmonary Functions, Respiratory Muscle Strength and Functional Capacity in COPD Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Keywords: kinesio taping
COPD
functional capacity
pulmonary functions
pulmonary rehabilitation
Lead sponsor: Dokuz Eylul University
Sponsor class: OTHER
First posted: 2018-04-12
Enrollment: 27
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to investigate the effect of kinseio taping on functional capacity, pulmonary functions, respiratory muscle strength, severity of dyspnea, severity of fatigue in Chronic Obstructive Pulmonary Disease (COPD). Assessment of patients was done baseline and 6th week.

Eligible patients for the study randomly allocated to Kinesio Taping Group (KTG), or Control Group (CG). Both groups received three different deep breathing exercises (diaphragmatic, thoracic, and lateral basal), each consisting of three sets of 10 repetitions, with 30 seconds of rest between each set. KTG also received thoracic kinesio taping application.


Eligibility criteria: Inclusion Criteria:

* aged 40 years and older,
* having stage II-III COPD diagnosis according to GOLD system and BODE Index by chest physician,
* unwilling to participate in any kind of pulmonary rehabilitation program for COPD,
* able to read, write, and understand Turkish; and
* willing and able to attend the study.

Exclusion Criteria:

* being in COPD exacerbation period,
* having neurological or musculoskeletal problems that would affect physical mobility,
* having unstable, severe heart disease(s) (heart failure, unstable hypertension, previous angina pectoris or myocardial infarction, heart valve problems),
* having scar, lesion or incision in the area of kinesio tape application,
* previous use of kinesio tape,
* having skin sensitivity against kinesio tape,
* malignancy,
* having mental and cognitive disorders that would affect cooperation.

Primary outcomes:
measure: Change in functional capacity
timeFrame: Baseline, 6th week
Secondary outcomes:
measure: Change in pulmonary functions
timeFrame: Baseline, 6th week
measure: Change in respiratory muscle strength
timeFrame: Baseline, 6th week
measure: Change in severity of dyspnoea
timeFrame: Baseline, 6th week
measure: Change in severity of fatigue
timeFrame: Baseline, 6th week
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: Dokuz Eylül Üniversitesi School of Physical Therapy and Rehabilitation
Study officials:
References:
Clinical trial NCT04784676: Internal Fit Evaluation of Indirect Restorations Using Cone Beam CT (CBCT)
Official title: Internal Fit Evaluation of Indirect Restorations Fabricated From CAD/CAM Composite Blocks Versus Ceramic Blocks in Badly Broken Teeth Using Cone Beam CT (CBCT)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Indirect Restoration of Badly Broken Vital Teeth
Keywords: randomized clinical trial
internal adaptation
CAD/CAM composite restoration
all ceramic restoration
E-max CAD
CAD/CAM milling system
CAD/CAD
composite
inlays
onlays
cone beam CT
CBCT
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2021-03-05
Enrollment: 42
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: randomized clinical trial parallel group, two arms, superiority trial, allocation ratio 1:1
Primary purpose: TREATMENT

Brief summary: this study was conducted to evaluate the internal fit of indirect restoration fabricated from CAD/CAM composite blocks versus ceramic blocks in badly broken vital teeth using cone beam CT

Detailed description: two parallel groups (n=42 restorations), patient having badly broken vital teeth minimum of two remaining wall will be randomly enrolled in this trial and receive restoration fabricated either from Grandio composite blocks or E-max ceramic blocks. internal fit evaluation of the fabricated restoration over their corresponding casts will be performed using cone beam CT just prior cementation of the restorations. data will be collected and statistically analyzed.

Eligibility criteria: Inclusion Criteria:

* patients with badly broken vital teeth young adult males or females (20-50 years) good oral hygeine cooperative patients approving to participate in the study

Exclusion Criteria:

* patients with acompromised medical history severe or active periodontal disease severe medical complications lack of compliance

Primary outcomes:
measure: internal fit evaluation
timeFrame: on cast before delivery
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: faculty of dentistry, Cairo University
state: Please Select...
Study officials:
affiliation: associate professor of conservative Dentistry, faculty of dentistry Cairo university Egypt
name: Shereen H Ibrahim, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ibrahim SH, Amr H, Hassan AA, Elzohairy A. Internal fit evaluation of indirect restorations fabricated from CAD/CAM composite blocks versus ceramic blocks in badly broken teeth using cone beam CT (CBCT): double-blinded randomized clinical trial. Heliyon. 2022 May 19;8(5):e09466. doi: 10.1016/j.heliyon.2022.e09466. eCollection 2022 May.
Clinical trial NCT03467776: Bronchial Dilation Test in Wheezy Infants
Official title: Brochial Dilation Test by Salbutamol Metered Dose Inhaler(MDI) With Spacer in Wheezy Infants With Asthma Risk Factors
Study type: OBSERVATIONAL
Overall status: SUSPENDED
Conditions: Asthma
Keywords: infants
asthma
bronchial dilation test
plethysmography
Lead sponsor: Guangzhou Institute of Respiratory Disease
Sponsor class: OTHER
Collaborators: name: Firestone Institute for Respiratory Health
First posted: 2018-03-16
Enrollment: 90
Sex: ALL
Minimum age (years): 5
Maximum age (years): 36
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: all the subjects will be recurited from the First Affiliated Hospital of Guangzhou Medical University

Brief summary: The purpose of the study is to establish the methodology of bronchial dilation test by salbutamol MDI with Spacer in wheezy infants with asthma and to evaluate the effects of atopy on the exacerbation of wheeze in wheezy infants.

Detailed description: After screening,each participant undergo baseline pulmonary function test(Jaeger Master Screen Baby Body, Germany)and post-bronchodilator measurements that performed 10min after 200ug of salbutamol administered using a metered-dose inhaler and a spacer.

The participants undergo baseline lung function test and bronchial dilation tests on the second and third visits with one-month interval,and whenever there is an exacerbation.

Eligibility criteria: Inclusion Criteria:

* normal term infants.Recurrent wheezing with or without atopy,none of the subjects had a history of respiratory illness, congenital heart disease,dysphagia,oxygen saturation≤90% on room air,an active seizure disorder,or upper airway obstruction,or requirement for assisted ventilation in the neonatal periods,all infants were asymptomatic for at least 2 weeks preceding the test.

Exclusion Criteria:

* subjects had a history of respiratory illness, congenital heart disease,dysphagia,oxygen saturation≤90% on room air,an active seizure disorder,or upper airway obstruction,;all infants were asymptomatic for at least 2 weeks preceding the test.

Primary outcomes:
measure: airway resistance(Raw) performed by body plethysmography before and after bronchial dilation test.
timeFrame: Change from baseline at 20 mins after inhalation of salbutamol
Secondary outcomes:
measure: airway resistance(Raw) performed by body plethysmography
timeFrame: at 24 hours of the exacerbation of wheeze
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: State Key Laboratory of Respiratory Disease;China Clinical Research Center of Respiratory Disease;First Affiliated Hospital of Guangzhou Medical University
state: Guangdong
Study officials:
affiliation: Guangzhou Institute of Respiratory Disease
name: jinping Zheng
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03241576: Provision of Small vs. Large Portion Sizes and Later Food Intake
Official title: Provision of Small vs. Large Portion Sizes and Later Self-selected Food Intake: 3 Experimental Laboratory Studies in UK Participants
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Eating Behavior
Lead sponsor: University of Liverpool
Sponsor class: OTHER
First posted: 2017-08-07
Enrollment: 307
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: In 3 laboratory experiments the effect that receiving a small vs. large portion size of food has on later intake of that food was examined

Detailed description: Historical increases in the size of commercially available food products have been linked to the emergence of a worldwide obesity crisis. Although the acute effect portion size has on food intake is well established, the effect that exposure to smaller portion sizes has on future portion size selection is yet to be examined.We tested whether reducing a food portion size may 'renormalize' perceptions of what constitutes a normal amount of food to eat and result in people selecting and consuming smaller portions of that food in future. Across three experiments participants were served a large or smaller portion of food. In experiments 1-2, twenty four hours later participants freely selected and consumed a portion of that food. In experiment 3, one week later participants reported on their preferred portion size of that food.

Eligibility criteria: Inclusion Criteria:

* 18 years or older

Exclusion Criteria:

* History of food allergy, eating disorder or currently dieting to lose weight

Primary outcomes:
measure: Later food intake (24 hour)
timeFrame: Measured 24 hours after random allocation (experiments 1 and 2)
measure: Later food intake (7 days)
timeFrame: Measured 7 days after allocation (experiment 3)
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Robinson E, Kersbergen I. Portion size and later food intake: evidence on the "normalizing" effect of reducing food portion sizes. Am J Clin Nutr. 2018 Apr 1;107(4):640-646. doi: 10.1093/ajcn/nqy013.
Clinical trial NCT05606276: Effects of Eccentric Potentiation Activation on Muscle Function
Official title: Effects of Multi-joint Eccentric Potentiation Maximal Contractions on Muscle Function
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Post Activation Potentiation
Lead sponsor: Utah State University
Sponsor class: OTHER
First posted: 2022-11-04
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Following a familiarization session, subjects will be assigned to an order for performing both an eccentric and a cycle (sham) session (i.e., crossover design, the order being randomized). These will be performed 3-7 days apart.
Primary purpose: OTHER

Brief summary: The purpose of this study is to examine the potentiation effects of 2 sets of multi-joint eccentric overload maximal contractions on muscle function.


Eligibility criteria: Exclusion Criteria:

* lower body surgery or injury in the last 12 months
* have any neuromuscular disease
* height \>76 inches tall
* height \<54 inches tall
* eccentric strength greater than 725 pounds
* pregnant or plan to be pregnant in the duration of the protocol
* don't do resistance exercise at least once per week
* perform intense cardio or strength training \>4 days per week
* Present with any other significant comorbid conditions that would impair the ability to participate in the exercise-based testing

Inclusion criteria:

* 18 - 30 years old
* strength train lower body 1-3 times per week

Primary outcomes:
measure: Vertical Jump
timeFrame: Baseline (pretest)
measure: Vertical Jump
timeFrame: Immediately post intervention
measure: Vertical Jump
timeFrame: 12 minutes post intervention
measure: Vertical Jump
timeFrame: 20 minutes post intervention
measure: Isokinetic eccentric maximal strength
timeFrame: Baseline (pretest)
measure: Isokinetic eccentric maximal strength
timeFrame: Immediately post intervention
measure: Isokinetic eccentric maximal strength
timeFrame: 12 minutes post intervention
measure: Isokinetic eccentric maximal strength
timeFrame: 20 minutes post intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Logan
country: United States
facility: Utah State University
state: Utah
Study officials:
affiliation: Utah State University
name: Brennan J Thompson, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05991076: Feasibility of a Community-based Dance Program for Latino Older Adults
Official title: Feasibility of Activate Bailando, a Community-based Dance Program, on Balance and Social Connectedness for Latino Older Adults
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mobility Limitation
Keywords: Hispanic/Latinos
Older Adults
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
Collaborators: name: Wisconsin Institute For Healthy Aging
First posted: 2023-08-14
Enrollment: 18
Sex: ALL
Minimum age (years): 55
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community-dwelling older adults including Spanish-speaking older adults are enrolled in Activate Bailando, a community-based dance class.

Brief summary: The objective of this study is to evaluate the feasibility and preliminary effectiveness of Activate Bailando, a 6-week community-based dance class offered in Spanish to older adults. 20 older adults in the Madison, Wisconsin area who are enrolled in Activate Bailando will complete a pre-and post-program test within 10 days for program start and completion.

Detailed description: The primary aim is to evaluate the feasibility of the Activate Bailando program based on measures of recruitment, retention, attendance, and acceptability.

The secondary aim is to evaluate the preliminary effectiveness of the program on metrics of balance, mobility, social connectedness, and fear of falling.

Eligibility criteria: Inclusion Criteria:

* Being over the age of 55
* Willing and able to participate in the Activate Bailando class
* Willing and able to complete data collection before and after the program

Exclusion Criteria:

* Not Being over the age of 55
* Not willing and able to participate in the Activate Bailando class
* Not willing and able to complete data collection before and after the program

Primary outcomes:
measure: Recruitment rate of participants who enroll in the study
timeFrame: Baseline
measure: Retention rate of participants who enroll and complete the study
timeFrame: Baseline, posttest (up to 7 weeks)
measure: Attendance of Class Participation
timeFrame: Posttest (up to 7 weeks)
measure: Acceptability of participation in the class
timeFrame: Posttest (up to 7 weeks)
Secondary outcomes:
measure: Change in University of California Los Angeles (UCLA) Loneliness Scale
timeFrame: Baseline, Posttest (up to 7 weeks)
measure: Change in Timed Up and Go Results
timeFrame: Baseline, Posttest (up to 7 weeks)
measure: Change in the 4-stage balance test
timeFrame: Baseline, Posttest (up to 7 weeks)
measure: Changes in Falls Efficacy Scale (Short Version)
timeFrame: Baseline, Posttest (up to 7 weeks)
measure: Changes in Lubben Social Network Scale (LSNS-6)
timeFrame: Baseline, Posttest (up to 7 weeks)
Other outcomes:
Locations:
city: Madison
country: United States
facility: Catholic Multicultural Center
state: Wisconsin
Study officials:
affiliation: UW Madison
name: Luis Columna, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06895876: Deep Parasternal Intercostal Plane Block
Official title: Deep Parasternal Intercostal Plane Block : Effect on the Quality of Postoperative Recovery After Cardiac Surgery
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Nerve Block
Keywords: Transversus thoracic muscle plane block
Cardiac surgery
Postoperative analgesia
Quality of recovery
QoR-15
Lead sponsor: Institute Arnault Tzanck, France
Sponsor class: OTHER
First posted: 2025-03-26
Enrollment: 128
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Cardiac surgery is a source of severe post operative pain witch can cause major respiratory complications due to non optimal post operative rehabilitation.

Multimodal analgesia provides acceptable pain control , but does not seem sufficient during coughing or mobilization. The use of morphine also exposes patients to side effects (nausea, vomiting, pruritus, respiratory depression, chronic pain, ileus). Bleeding and hemodynamic risks of peridural and spinal aneshesia limits their use.

The postoperative efficacy of deep parasternal intercostal plane block has not yet been evaluated sufficiently. The aim of this study is to evaluate the efficacity of TTMPB on the quality of postoperative recovery after cardiac surgery.


Eligibility criteria: Inclusion Criteria:

* Patients requiring cardiac surgery with sternotomy

Exclusion Criteria:

* Emergency procedure
* Procedures requiring lateral chest drainage
* Hemodynamic instability
* Severe kidney or liver failure
* BMI \> 40
* Chronic pain
* Allergy to local anesthesics
* Pregnant woman
* Long term opioïds use

Primary outcomes:
measure: Quality of recovery 15 (QoR-15)
timeFrame: 24 hours after surgery
Secondary outcomes:
measure: Total morphine consumption at 24 hours
timeFrame: 24 hours after surgery
Other outcomes:
Locations:
city: Saint Laurent du Var
country: France
facility: Institut Arnault Tzanck
Study officials:
References:
citation: Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. Br J Anaesth. 1997 May;78(5):606-17. doi: 10.1093/bja/78.5.606.
citation: Mangano DT, Siliciano D, Hollenberg M, Leung JM, Browner WS, Goehner P, Merrick S, Verrier E. Postoperative myocardial ischemia. Therapeutic trials using intensive analgesia following surgery. The Study of Perioperative Ischemia (SPI) Research Group. Anesthesiology. 1992 Mar;76(3):342-53.
citation: Aydin ME, Ahiskalioglu A, Ates I, Tor IH, Borulu F, Erguney OD, Celik M, Dogan N. Efficacy of Ultrasound-Guided Transversus Thoracic Muscle Plane Block on Postoperative Opioid Consumption After Cardiac Surgery: A Prospective, Randomized, Double-Blind Study. J Cardiothorac Vasc Anesth. 2020 Nov;34(11):2996-3003. doi: 10.1053/j.jvca.2020.06.044. Epub 2020 Jun 18.