Clinical trial NCT00755014: Study Effect of Red Wine Consumption on Endothelial Progenitor Cells and Endothelial Function
Official title: Taipei Veterans General Hospital
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Endothelial Progenitor Cells Numbers
Endothelial Function (FMD)
Lead sponsor: Taipei Veterans General Hospital, Taiwan
Sponsor class: OTHER_GOV
Collaborators: name: National Yang Ming Chiao Tung University
First posted: 2008-09-18
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Light-to-moderate alcohol consumption has been associated with a reduction of cardiovascular events, and red wine seems to offer more benefits than any other type of alcoholic beverages. However, the relationship between red wine consumption and endothelial progenitor cells (EPCs) remains unclear. The investigators examine whether intake of red wine could enhance the number or functional capacity of circulating EPCs by upregulation of nitric oxide (NO) bioavailability.

Detailed description: Moderate ethanol intake from any type of beverage has been shown to improve lipoprotein metabolism and lower cardiovascular mortality risk, but red wine, with its abundant antioxidant contents, seems to confer additional healthy benefits. Previous studies indicated that the beneficial effects of red wine are derived from increased endothelium-derived nitric oxide (NO), implying that enhanced NO bioavailability may mediate the cardiovascular protection provided by red wine.

Increasing evidence suggests that the injured endothelial monolayer is regenerated partly by circulating bone marrow derived-endothelial progenitor cells (EPCs), which accelerate reendothelialization and protect against the initiation and progression of atherosclerosis. Clinical studies demonstrated that the number of circulating EPCs predicts the occurrence of cardiovascular events and death from cardiovascular causes and may help to identify patients at increased cardiovascular risk. Although many epidemiologic studies have indicated that light-to-moderate consumption of red wine can reduce the incidence of CAD, the multifarious effects of red wine on circulating EPCs and endothelial function remain to be determined. Therefore, we design this study to test the hypothesis that intake of red wine can enhance the number and functional capacity of EPCs through increasing NO bioavailability.

Eligibility criteria: Inclusion Criteria:

* Forty young healthy subjects with no cardiovascular risk factors

Exclusion Criteria:

* History of hypertension
* Diabetes mellitus
* Symptoms of CAD
* Smoking
* Chronic renal insufficiency (serum creatinine \> 1.5 mg/dl)
* Inflammatory or liver diseases
* Regular alcohol consumption (drinking more than 20 g of ethanol per week)

Primary outcomes:
measure: Number of endothelial progenitor cells, endothelial function (FMD)
timeFrame: VGH-97DHA0100127
Secondary outcomes:
measure: Plasma NO, hsCRP, ADMA, TNF-a, adiponectin, ox-LDL levels
timeFrame: VGH-97DHA0100127
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Veterans Generla Hospital
Study officials:
affiliation: Division of Cardiology, Taipei Veterans General Hospital
name: Shing-Jong Lin, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Division of Cardiology, Taipei Veterans General Hospital
name: Po-Hsun Huang, MD
role: STUDY_DIRECTOR
References: