louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02552420: The Clinical Application of Infrared Thermal Imaging Detecting Venous Thromboembolism
Official title: The Clinical Application of Infrared Thermal Imaging Detecting Venous Thromboembolism
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Deep Venous Thrombosis
Keywords: infrared thermal imaging
deep venous thrombosis
Lead sponsor: The First Affiliated Hospital of Guangzhou Medical University
Sponsor class: OTHER
First posted: 2015-09-17
Enrollment: 128
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Sampling method: NON_PROBABILITY_SAMPLE
Study population: DVT patients included in this study had been definitively diagnosed as having DVT with CPUS and/or angiography. Included non-DVT volunteers were confirmed to be without DVT with CPUS. The healthy volunteer group matched the DVT group in number, age, and gender.

Brief summary: The purpose of this study is to determine the effectiveness of infrared thermal imaging in adjunctive diagnostic screening for lower limb deep venous thrombosis (DVT).


Eligibility criteria: Inclusion Criteria:

1. Willing to participate in the trial and sign the informed consent form,
2. Aged: 18-75 years. They had been definitively diagnosed with venous thromboembolism,
3. The bed-rest immobilization time should be more than 72 hours,
4. Planing to gynecology operation,
5. The D dimer should be more than500 g • L-1,
6. There is no obvious symptoms of systemic infection two weeks before the test,
7. There is no trauma, infection, biopsy or puncture, hemorrhage and tumor in the corresponding detection site (chest and lower limbs),
8. There is no skin disease, heart, liver, kidney, gastrointestinal tract, hematopoietic system and mental, neurological has no serious diseases.

Exclusion Criteria:

1. Patients can not be good partners,
2. Doctors believe that there is any inappropriate situations.

Primary outcomes:
measure: Using the Infrared Thermal Imaging to detecting Venous Thromboembolism
timeFrame: up to 24 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05842720: Consented Unsedated Endoscopy in High Risk Patients That Require Anesthesiologist Observation During the Procedure
Official title: Consented Unsedated Endoscopy in High Risk Patients That Require Anesthesiologist Observation During the Procedure.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Patient Satisfaction
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2023-05-06
Enrollment: 69
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study aim to examine the safety and feasibility of unsedated colonoscopy in patients with high risk for sedation (ASA score≥3).

Detailed description: This was a two-part study: Part 1 was a retrospective study of patients with ASA score≥3 that underwent unsedated colonoscopy from May 2021 to August 2022 at Sheba medical center, who were contacted up to one year after the procedure and were asked to assess their satisfaction and pain level on a standard Likert score from 1-5. Part 2 was a prospective study which included high risk patients who were scheduled for an anesthesiologist-assisted sedated-colonoscopy and who consented to undergo an unsedated procedure. The primary outcome was patients' satisfaction during and up to one week after the procedure. Pain level, adverse events and hemodynamic parameters during the procedure were secondary outcomes. Baseline State-Trait Anxiety Inventory (STAI) questionnaire were also administered and results examined vis-à-vis satisfaction scores

Eligibility criteria: Inclusion Criteria:

* Only adults (\>18 years of age) that will be assessed as high risk and require an anesthesiologist clinic assessment prior to the procedure and anesthesiologist presence during the procedure.

Exclusion Criteria:

1. Patients that are planned to go through both gastroscopy and colonoscopy procedures.
2. Patients with known adhesions and/or prior small bowel obstructions.
3. Patients that are planned to have a complicated procedure (complicated polypectomy etc).
4. Patients that are not able to give their consent with a full understanding of the procedure.
5. Patients that are pregnant.
6. Patients with a heart rate above 120 bpm or less than 40 bpm at the baseline as measured before starting the procedure.
7. Patients with a systolic blood pressure above 180mmHg or bellow 90mmHg as measured at the baseline before starting the procedure.

Primary outcomes:
measure: satisfaction rate
timeFrame: up to 1 week after the date of the procedure
Secondary outcomes:
measure: Recovery time after the procedure
timeFrame: up to 24 hours after the procedure
measure: Complications or adverse effects rates during the procedure
timeFrame: from the beginning of the procedure until the end of the procedure
measure: Complete examination rates
timeFrame: from the beginning of the procedure until the end of the procedure
Other outcomes:
Locations:
city: Ramat Gan
country: Israel
facility: Sheba medical center Tel Hashomer
Study officials:
References:
Clinical trial NCT03230682: Eealy Improvement Predicts Antidepressants Response in Adults With Major Depression Disorder
Official title: Eealy Improvement Predicts Antidepressants Response in Adults With Major Depression Disorder
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Major Depressive Disorder
Keywords: early improvement
antidepressants
major depression diorder
resting-state fMRI
Lead sponsor: Huashan Hospital
Sponsor class: OTHER
First posted: 2017-07-26
Enrollment: 80
Sex: ALL
Minimum age (years): 16
Maximum age (years): 55
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The han nationality who living in Shanghai, Zhejiang Province and Jiangsu Province

Brief summary: Early improvemrnt, decreased 20% in the 17 items of Hamilton Depression Rating Scale (HAMD-17) at the second week of the treatment of major depression disorder (MDD), can arguably predict the remission at the 12th week. Our observation study including 80 MDD patients will access resting-state function MRI to finding factors which infuencing early improvemrnt, respone and remission of antidepressants.


Eligibility criteria: Inclusion Criteria:

* right-handed; HAMD-17 more than 17; diagnosed with MDD by the Structured Clinical Interview for DSM-IV

Exclusion Criteria:

* patients diagnosed with other condition in DSM-IV Axis I; pregnency; Thyroid disease; Heart Disease

Primary outcomes:
measure: Early improvement
timeFrame: the second week of treatment
Secondary outcomes:
measure: Response
timeFrame: the 12th week of treatment
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Dept. of Neurology, Huashan Hospital, Fudan University
state: Shanghai
Study officials:
References:
citation: Wagner S, Engel A, Engelmann J, Herzog D, Dreimuller N, Muller MB, Tadic A, Lieb K. Early improvement as a resilience signal predicting later remission to antidepressant treatment in patients with Major Depressive Disorder: Systematic review and meta-analysis. J Psychiatr Res. 2017 Nov;94:96-106. doi: 10.1016/j.jpsychires.2017.07.003. Epub 2017 Jul 4.
citation: Szegedi A, Jansen WT, van Willigenburg AP, van der Meulen E, Stassen HH, Thase ME. Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder: a meta-analysis including 6562 patients. J Clin Psychiatry. 2009 Mar;70(3):344-53. doi: 10.4088/jcp.07m03780. Epub 2009 Feb 24.
Clinical trial NCT06327282: the Effect of Preoperative Pain Education by Anesthesia Nurses on Postoperative Pain Among Adult Patients Undergoing Abdominal Surgery
Official title: the Effect of Preoperative Pain Education by Anesthesia Nurses on Postoperative Pain Among Adult Patients Undergoing Abdominal Surgery
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Postoperative Pain
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
First posted: 2024-03-25
Enrollment: 116
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients undergoing Abdominal Surgery

Brief summary: To explore the effects of preoperative pain education on postoperative pain among patients undergoing abdominal surgery.


Eligibility criteria: Inclusion Criteria:

1. voluntary informed consent;
2. age older than 18 years
3. abdominal surgery under elective general anesthesia

Exclusion Criteria:

1. Patients taking long-term analgesics (including opioids, non-steroids, etc.)
2. Patients with preoperative chronic pain
3. Have participated in clinical studies in other projects within 3 months prior to signing the informed consent form
4. subjects not considered by the investigator
5. subjects refused to participate in the study

Primary outcomes:
measure: Occurrence of pain
timeFrame: The first day to the fifth day after surgery.
Secondary outcomes:
measure: Mastery of the use of patient-controlled analgesia pump
timeFrame: Day 2 after surgery
Other outcomes:
measure: Patient satisfaction with postoperative analgesia
timeFrame: Day 5 after surgery
measure: Adverse events of patients using analgesic pump were recorded
timeFrame: The first day to the fifth day after surgery.
measure: The number of times that the analgesic pump was pressed during each 24h and the amount of analgesic pump remaining at this time were recorded
timeFrame: The first to three days after surgery
measure: The use of rescue analgesics after surgery
timeFrame: The first day to the fifth day after surgery.
measure: The postoperative sleep status of patients was evaluated
timeFrame: The first day to the fifth day after surgery.
Locations:
Study officials:
References:
Clinical trial NCT05672082: Contribution of [18F]DPA-714 PET for Grading and Exploration of the Inflammatory Microenvironment of Glioma.
Official title: Contribution of [18F]DPA-714 PET for Grading and Exploration of the Inflammatory Microenvironment of Glioma, a Pilot Study
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Glioma
Lead sponsor: Center Eugene Marquis
Sponsor class: OTHER
First posted: 2023-01-05
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The 18-kDa translocator protein (TSPO) is a mitochondrial protein that is weakly expressed in the healthy brain. However, there is an increase in the expression of TSPO in glial tumors. It is even associated with a higher malignancy and a shorter survival of patients. Among the different TSPO ligands, the most commonly used tracers in PET imaging are \[18F\]DPA-714 and 18F-GE180. We hypothesize that \[18F\]DPA-714 PET could improve the current performance for tumor grade definition in vivo, which is a major issue for the therapeutic management of gliomas.


Eligibility criteria: Inclusion Criteria:

* Age greater than or equal to 18 years
* Suspicion of an operable diffuse glioma
* Written informed consent (signed)
* Affiliated or beneficiary of a social security plan

Exclusion Criteria:

* Suspicion of grade I glioma
* Surgical urgency (less than 8 days between the suspected diagnosis and surgery)
* Pregnant or breastfeeding woman
* Persons deprived of liberty or under guardianship
* Impossibility to undergo the medical follow-up of the trial for geographical, social or psychological reasons

Primary outcomes:
measure: Diagnostic performances of [18F]DPA-714 PET for glioma grading obtained by stereotactic biopsies of glioma
timeFrame: [18F]DPA-714 PET performed up to 30 days before brain surgery
Secondary outcomes:
measure: Comparison of [18F]DPA-714 PET quantitative parameters with anatomopathological assessment of the surgery specimen
timeFrame: [18F]DPA-714 PET performed up to 30 days before brain surgery
measure: Comparison of [18F]DPA-714 PET quantitative parameters with tumor microenvironment
timeFrame: [18F]DPA-714 PET performed up to 30 days before brain surgery
Other outcomes:
Locations:
Study officials:
affiliation: Centre de lutte contre le cancer Eugène Marquis
name: Xavier PALARD NOVELLO, Dr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03975582: Somnotouch-NIBP Compared to Standard Ambulatory 24-hours Blood Pressure Measurement
Official title: Somnotouch-NIBP Compared to Standard Ambulatory 24 Hours Blood Pressure Measurement - a Prospective Registry
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Blood Pressure
Lead sponsor: University Hospital, Basel, Switzerland
Sponsor class: OTHER
First posted: 2019-06-05
Enrollment: 115
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients from the medical outpatient clinic of the University Hospital of Basel with an indication for an ambulatory 24h blood pressure measurement.

Brief summary: Comparison of 24 hours blood pressure measurement with puls-transit time versus cuffs.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years
* Ability to give informed consent

Exclusion Criteria:

* Age \< 18 years
* Medical reasons that forbid blood pressure measurements on upper extremities
* Not able to give informed consent

Primary outcomes:
measure: Difference in mean 24 hours systolic blood pressure
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Basel
country: Switzerland
facility: University Hospital Basel
state: Basel Stadt
Study officials:
affiliation: University Hospital, Basel, Switzerland
name: Thilo Burkard, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05935982: Virtual Reality Exercise in a Community Highschool for Children With Disabilities
Official title: Preliminary Implementation and Development of an Enjoyable Virtual Reality Exercise Program for the Prevention of Cardiometabolic Disease Among Children With Disabilities in School Settings
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Disability Physical
Developmental Disability
Physical Inactivity
Lead sponsor: University of Alabama at Birmingham
Sponsor class: OTHER
Collaborators: name: National Institute on Minority Health and Health Disparities (NIMHD)
First posted: 2023-07-07
Enrollment: 9
Sex: ALL
Minimum age (years): 13
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of this study is to work with a community engagement group to develop and pilot a protocol for a virtual reality exergaming program for children with special needs at a high school.

Detailed description: A virtual reality exercise program will be run during school special physical education hours at a public high school. The program will be implemented by a person with cerebral palsy. The exercise will include rhythmic movement to music and fitness games.

Eligibility criteria: Inclusion Criteria:

* Enrolled in school special physical education or self-reported disability
* Note from physician permitting participation in moderate intensity exercise or cleared for sport participation through physical examination that was on file by the school
* Ability to communicate in English (or a caregiver)

Exclusion Criteria:

* Complete blindness or deafness
* Condition that may make participation unsafe

Primary outcomes:
measure: Attendance
timeFrame: Weeks 1 to 6
measure: Move Minutes
timeFrame: Weeks 1 to 6
Secondary outcomes:
measure: Walking Endurance
timeFrame: Week 1 and Week 6
measure: Hand Grip Strength
timeFrame: Week 1 and Week 6
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Children's Hospital of Alabama
state: Alabama
Study officials:
affiliation: University of Alabama at Birmingham
name: Byron Lai, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT07008482: "Effects of Music on Preoperative Anxiety in Patients With Femoral Fractures Undergoing Surgery: A Randomized Controlled Trial"
Official title: "Effects of Music on Preoperative Anxiety in Patients With Femoral Fractures Scheduled for Surgical Intervention: A Randomized Controlled Study"
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Anxiety
Pain
Surgery
Femoral Fractures
Music Therapy
Keywords: NURSING
MUSICTHERAPY
ANXIETY
PAIN
Lead sponsor: Azienda Unita Sanitaria Locale di Piacenza
Sponsor class: OTHER
First posted: 2025-06-06
Enrollment: 154
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This randomized controlled trial (RCT) investigates the effectiveness of music therapy in reducing preoperative anxiety among elderly patients with femoral fractures. Preoperative anxiety is known to worsen physiological stability, increase pain perception, and negatively impact recovery, yet specific evidence on non-pharmacological interventions like music therapy in the orthogeriatric setting is lacking.

The study will enroll 154 adult patients admitted to the Orthogeriatrics Unit for elective femoral fracture surgery. Participants will be randomly assigned to receive either a 20-minute session of music therapy or standard care. Anxiety will be measured using the APAIS scale, and pain will be assessed with the NRS scale, both before and after the intervention.

The trial is designed as a blinded, prospective RCT, with data collected and managed under current privacy regulations. By generating robust data on this low-cost, safe intervention, the study aims to improve preoperative management and patient outcomes in orthopedic surgical care.


Eligibility criteria: Inclusion Criteria:

* Patients of both sexes, 18 years of age or older
* Patients with femur fracture who are candidates for surgery
* Able to provide informed consent.

Exclusion Criteria:

* Patients with a diagnosis of hearing loss
* Patients diagnosed with cognitive or psychiatric disorders
* Patients undergoing emergency/emergency surgery

Primary outcomes:
measure: Reduction APAIS
timeFrame: 20 MINUTES
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03100682: Prevention of Human Papillomavirus (HPV) Infection in Paediatric Kidney and Liver Transplant Recipients and in Paediatric Patients With Advanced Chronic Kidney Disease
Official title: Prevention of Human Papillomavirus (HPV) Infection in Paediatric Kidney and Liver Transplant Recipients and in Paediatric Patients With Advanced Chronic Kidney Disease: a Prospective, Observational Multi-centre Vaccine Surveillance Study (HPVaxResponse Study)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Paediatric Kidney or Liver Transplantation
Chronic Kidney Disease
Lead sponsor: University Hospital Heidelberg
Sponsor class: OTHER
First posted: 2017-04-04
Enrollment: 140
Sex: ALL
Minimum age (years): 9
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Paediatric Kidney and/or Liver transplant recipients Paediatric patients with CKD

Brief summary: Due to their immunosuppressive therapy, solid-organ transplant (SOT) recipients bear a 10 to 100 times higher risk of human papillomavirus (HPV)-associated malignancies than healthy individuals. The objectives of this observational, non-interventional multi-national, multi-centre research project are to gain an insight into current HPV vaccination strategies and to investigate the immune response to different routinely administered HPV vaccines in European paediatric SOT candidates and immunocompromised transplant recipients, enabling patients at risk of vaccination failure to be identified.


Eligibility criteria: Inclusion Criteria:

* Paediatric Kidney and/or Liver transplant recipients
* Paediatric patients with CKD
* Who receive HPV vaccination according to country-specific vaccine schedule

Exclusion Criteria:

* No HPV vaccination according to country-specific vaccine schedule
* No written informed consent

Primary outcomes:
measure: Immune Response to HPV vaccine
timeFrame: Change of immune response from baseline (prior to vaccination) to 4-12 weeks after vaccination and to 18+- 3 months after vaccination will be assessed.
Secondary outcomes:
Other outcomes:
Locations:
city: Heidelberg
country: Germany
facility: University Children's Hospital
Study officials:
affiliation: University Children's Hospital of Heidelberg
name: Britta Hoecker, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05396482: Assesment of Hearing in Patients With Vestibular Migra
Official title: Assesment of Hearing in Patients With Vestibular Migraine
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Vestibular Migraine
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2022-05-31
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with vestibular migraine

Brief summary: Evaluation of hearing in patients with vestibular migraine


Eligibility criteria: Inclusion Criteria:

* vertigo

Exclusion Criteria:

* hypertension

Primary outcomes:
measure: Pathology
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University
Study officials:
References: