Clinical trial NCT02904720: Prevalence and Consequences of Vitamin D Deficiency in Pregnant Women in Switzerland
Official title: Prevalence and Consequences of Vitamin D Deficiency in Pregnant Women in Switzerland
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Vitamin D Deficiency
Keywords: Vitamin D; Pregnancy
Lead sponsor: Insel Gruppe AG, University Hospital Bern
Sponsor class: OTHER
Collaborators: name: Significantis GmbH
First posted: 2016-09-19
Enrollment: 1199
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All the pregnant women attending prenatal care and giving birth at birth at our clinic

Brief summary: The purpose of this study is to determine the prevalence of vitamin D deficiency among the population of pregnant women receiving prenatal care and giving birth at the investigators' clinic. The further purposes are to identify the population at risk for vitamin D deficiency and to analyse whether vitamin D deficiency is associated with pregnancy complications.


Eligibility criteria: Inclusion Criteria:

* Pregnant women attending prenatal care at our clinic who had a vitamin D blood-testing at admission

Exclusion Criteria:

* Pregnant women lost to follow-up, Birth outside our clinic

Primary outcomes:
measure: Prevalence of vitamin D deficiency
timeFrame: Between the 1th and the 36th week of pregnancy
Secondary outcomes:
measure: BMI as a risk factor for vitamin D deficiency
timeFrame: Between the 1th and the 36th week of pregnancy
measure: Ethnicity as a risk factor for vitamin D deficiency
timeFrame: Between the 1th and the 36th week of pregnancy
measure: Age as risk factor for vitamin D deficiency
timeFrame: Between the 1th and the 36th week of pregnancy
measure: Period of the year as risk factor for vitamin D deficiency
timeFrame: Between the 1th and the 36th week of pregnancy
measure: Smoking Status as risk factor for vitamin D deficiency
timeFrame: Between the 1th and the 36th week of pregnancy
measure: Association between vitamin D blood level and gestational diabetes mellitus
timeFrame: Between the 1th and the 36th week of pregnancy
measure: Association between vitamin D blood level and gestational hypertension and preeclampsia
timeFrame: Between the 1th and the 36th week of pregnancy
Other outcomes:
measure: Association between vitamin D blood level and the mode of delivery at birth
timeFrame: At delivery time
measure: Association between vitamin D blood level and the gestational age at delivery
timeFrame: At delivery time
measure: Association between vitamin D blood level and newborn growth
timeFrame: From week 1 until birth
Locations:
city: Bern
country: Switzerland
facility: University Hospital Bern
Study officials:
affiliation: Insel Gruppe AG, University Hospital Bern
name: Daniel Surbek, Professor
role: STUDY_DIRECTOR
References:
citation: Christoph P, Challande P, Raio L, Surbek D. High prevalence of severe vitamin D deficiency during the first trimester in pregnant women in Switzerland and its potential contributions to adverse outcomes in the pregnancy. Swiss Med Wkly. 2020 May 28;150:w20238. doi: 10.4414/smw.2020.20238. eCollection 2020 May 18.