Clinical trial NCT03336294: Functional Characteristic Properties of Skeletal Muscle Tissue Assessed by P31 Spectroscopy in Young and Older Adults
Official title: Functional Characteristic Properties of Skeletal Muscle Tissue Assessed by P31 Spectroscopy in Young and Older Adults
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Sarcopenia
Keywords: Sarcopenia
Muscle strength
SRM P31
Phosphocreatine
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2017-11-08
Enrollment: 1
Sex: MALE
Minimum age (years): 25
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: P31 nuclear magnetic resonance (RMN) Spectroscopy (SRM P31) has currently being poorly used in the field of sarcopenia.

The aim of the CAMUS study is to investigate the feasibility a protocol of SRM P31 at rest, during and after a standardized physical task. The secondary objective is to compare the metabolism of tyhe skeletal muscle tissue assessed by SRM P31 in young and older individuals. A pilot study, cross-sectional study will be conducted. Ten healthy sedentary 70+ years males and 10 sedentary 25 to 30 years old male will be included.

Level of physical activity, physical performances, will be assessed at baseline. RMN (T1; tractography and SRM P31) will be performed. SRM P31 will be performed at rest, during and after an exhausting muscle task at 70% 1-RM. Feasibility will be judged on the rate of valuable variables recorded (\>90%) inorganic phosphate (iP), phosphocreatine (PCr) and isoform of adenosine triphosphate (ATP : alfa, beta, gamma).


Eligibility criteria: Inclusion Criteria:

* Old group : 70+ years males
* Young group : 25 to 30 years males
* Sedentary males in the 2 groups
* Informed consent

Exclusion Criteria:

* Contraindication to perform a RMN

Primary outcomes:
measure: SRM P31 assessment
timeFrame: Change of SRM P31 between Before and during a standardized physical task
measure: SRM P31 assessment
timeFrame: Change of SRM P31 between during and after a standardized physical task
Secondary outcomes:
measure: T1; tractography and SRM P31 comparison between young and older sedentary adults
timeFrame: Change between Before and during a standardized physical task
measure: T1; tractography and SRM P31 comparison between young and older sedentary adults
timeFrame: Change between during and after a standardized physical task
Other outcomes:
Locations:
city: Toulouse
country: France
facility: University Hospital Toulouse
Study officials:
affiliation: University Hospital, Toulouse
name: Yves ROLLAND, MD; PHD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Rolland Y, Lauwers-Cances V, Cournot M, Nourhashemi F, Reynish W, Riviere D, Vellas B, Grandjean H. Sarcopenia, calf circumference, and physical function of elderly women: a cross-sectional study. J Am Geriatr Soc. 2003 Aug;51(8):1120-4. doi: 10.1046/j.1532-5415.2003.51362.x.
citation: Bourdel-Marchasson I, Joseph PA, Dehail P, Biran M, Faux P, Rainfray M, Emeriau JP, Canioni P, Thiaudiere E. Functional and metabolic early changes in calf muscle occurring during nutritional repletion in malnourished elderly patients. Am J Clin Nutr. 2001 Apr;73(4):832-8. doi: 10.1093/ajcn/73.4.832.