louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04130373: Multicentric Risk Evaluation of Autologous Fat Grafting Procedure
Official title: Multicentic Retrospective Evaluation of Risks in Mammary Carcinoma Relapse in Patients With Mammary Reconstruction and Autologous Fat Grafting
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pain, Postoperative
Keywords: Autologous fat grafting
Lipofilling
Breast cancer
Breast reconstruction
Lead sponsor: Humanitas Clinical and Research Center
Sponsor class: OTHER
First posted: 2019-10-17
Enrollment: 6510
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Female patients with breast carcinoma (any histological type, carcinoma in situ included) and treated with radical or conservative surgery and lipofilling. Patients received a minimum of two year follow up.

Brief summary: Autologous fat grafting, also known as lipofilling, is a surgical technique consisting in the processing and transfer of adipose tissue from one area in our organism (hips, thighs) to region which in need of reconstructive and aesthetic correction. The technique is frequently used after radical or conservative mammary surgery, aiming to achieve better aesthetic results, reduce pain induced by both surgery and radiotherapy. The scientific community was widely involved in the debate regarding the use of mesenchymal/stem cells in a patient with high risk of tumor progression due to their elevated proliferative profile. This study aims to retrospectively evaluate the oncological safety in the use of lipofilling in patients who underwent oncological and reconstructive treatment in our Institute.


Eligibility criteria: Inclusion Criteria:

* female
* breast carcinoma (any histological type, carcinoma in situ included) treated with radical or conservative surgery
* group treated with lipofilling and group which didnt receive lipofilling
* timing: retrospective evaluation of cases form 2006 to 2016, with a minimum of two year follow up

Exclusion Criteria:

* neoplasie different from infiltrating and in sutu breast carcinoma
* in situ lobular carcinoma
* patients with breast carcinoma and metastasis
* lipofilling procedure used before the oncological treatment for breast carcinoma

Primary outcomes:
measure: Oncological safety of autologous fat grafting
timeFrame: Two years
Secondary outcomes:
measure: Establishment of timing in disease relapse
timeFrame: Two years
measure: Establish the distribution in disease relapses
timeFrame: Two years
measure: Establish overall survival rate in experimental and control groups
timeFrame: Two years
Other outcomes:
Locations:
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas
state: Milan
Study officials:
affiliation: Istituto Clinico Humanitas
name: Marco Klinger, MD
role: STUDY_CHAIR
References:
Clinical trial NCT06691373: Acute Effects of Static Stretching on the Knee Joint Position Sense of Soccer Players
Official title: Acute Effects of Static Stretching on the Knee Joint Position Sense of Soccer Players: a Crossover Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Static Stretching
Joint Position Sense
Proprioception
Knee
Soccer
Lead sponsor: University Fernando Pessoa
Sponsor class: OTHER
First posted: 2024-11-15
Enrollment: 17
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The aim of this study was to investigate the acute effects of static stretching on the knee joint-position sense of soccer players.

Detailed description: This crossover randomized controlled trial included male soccer players. All participants performed 3 conditions: two experimental conditions, of static stretching of the quadriceps and hamstrings muscles, for 30 or 90 seconds; and a control condition (rest). Knee joint-position sense of the dominant limb was assessed before and immediately after the conditions for the range of 45º of knee flexion by active repositioning, using a video camera. Absolute, relative and variable angular errors were calculated.

Eligibility criteria: Inclusion Criteria:

* male soccer players
* aged between 18 and 30 years old
* with normal knee range of motion
* without history of lower limb injuries in the last 6 months

Exclusion Criteria:

* history of knee surgery
* with cardiorespiratory, neurological or vestibular diseases
* with positive knee integrity tests (anterior drawer, posterior drawer, Lachman test and valgus and varus stress tests)
* using drugs that could affect the central nervous system, balance, or motor control (sedatives, anxiolytics, analgesics, NSAIDs, muscle relaxants, or antibiotics).

Primary outcomes:
measure: Absolute angular error
timeFrame: Change from Baseline (Pre) to Immediately after interventions or control (Post)
measure: Relative angular error
timeFrame: Change from Baseline (Pre) to Immediately after interventions or control (Post)
measure: Variable angular error
timeFrame: Change from Baseline (Pre) to Immediately after interventions or control (Post)
Secondary outcomes:
Other outcomes:
Locations:
city: Porto
country: Portugal
facility: Escola Superior de Saúde Fernando Pessoa
Study officials:
References:
Clinical trial NCT03870373: Performance of Pulse Oximeter Sensors in Neonates
Official title: Validate Pulse Oximeter Sensors in Neonates by Comparing Sensor Readings to Blood Samples During Cardiac Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiac Surgery
Lead sponsor: Taiwan Aulisa Medical Devices Technologies, Inc.
Sponsor class: INDUSTRY
Collaborators: name: University of California, San Francisco
First posted: 2019-03-12
Enrollment: 15
Sex: ALL
Minimum age (years): 0
Maximum age (years): 1
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Neonatal patients undergoing complex cardiac surgical procedures.

Brief summary: Validate pulse oximeter sensors in neonates by comparing sensor readings to blood samples during cardiac surgery.

Detailed description: Researchers at the University of California, San Francisco have developed methods that permit them to test multiple pulse oximeter sensors on neonates simultaneously during cardiac surgery. During this type of surgery, the arterial oxygen saturation changes over a wide range, providing an ideal arena for the assessment of neonatal pulse oximeter sensors at many levels of oxygen saturation. Several arterial blood gas samples are typically obtained during these procedures. Saturation of each arterial blood sample is determined by direct oximetry in a hemoximeter and this measurement is compared to the reading displayed on the pulse oximeter.

Eligibility criteria: Inclusion Criteria:

* Neonates scheduled to undergo cardiac surgery where routine blood draws would be taken
* Consent signed by at least one legal guardian

Exclusion Criteria:

* Presence of any skin irritation or breakdown on the foot
* Foot impediments which would preclude proper placement of the sensor
* Clinical condition precluding the use of adhesive materials

Primary outcomes:
measure: Performance of Pulse Oximeter Sensor in Neonates
timeFrame: Data are collected anywhere from the beginning of surgery until the completion of the procedure
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: UCSF Medical Center at Mission Bay
state: California
Study officials:
affiliation: UCSF Medical Center at Mission Bay
name: Hung G Nguyen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01129973: Profile of Marketing Professional Audiologist Who Works in the Area of Audiology Clinic
Official title: Profile of Marketing Professional Audiologist Who Works in the Area of Audiology Clinic
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Audiologist
Fortaleza
Keywords: speech and language
phonoaudiology
marketing
Lead sponsor: Fortaleza University
Sponsor class: OTHER
First posted: 2010-05-25
Enrollment: 30
Sex: ALL
Minimum age (years): 24
Maximum age (years): 44
Standard ages: ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: replied to the questionnaire speech pathologists, of both sexes, active in the area of audiology clinic, of the city of Fortaleza, Ceará.

Brief summary: the audiology has achieved a great advance, where currently speech pathologists act in private clinics and in public services, in addition to schools, colleges and universities. To observe the development of the area of Audiology in Brazil, we note that there is a growing number of new audiology procedures. In 1980 the practice of audiology was limited in hospitals, offices and private clinics, and in 1988 due to a new constitution that devoted attention to protection of health of workers, opened-if more than one field of work, the audiology occupational, because of the hearing losses induced by noise

Detailed description: The area of audiology referred-if the science of hearing, auditory processing and corporal balance. The speech pathologist, Especialista em Audiologia, identifies, assesses and rehabilitation, empowering people with disabilities peripheral or central auditory, influencing the emergence of human communication disorders, as well as the balance disorders

Eligibility criteria: Inclusion Criteria:

* the professionals working with clinical audiology

Exclusion Criteria:

* the professionals who do not act in the city of Fortaleza or refuse to sign the Term of Free and Informed Consent

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Fortaleza University
name: Cleiciane M Braga, Graduate
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06216873: Collecting the Results of Multiple Trauma Patients and Find the Correlation of Morality and Mobility
Official title: Collecting the Results of Physical Examination, Blood Test, and Radiological Examination of Multiple Trauma Patients With Activated Trauma Team and Understanding the Correlation With Patient's Morality and Mobility
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Multiple Trauma/Injuries
Keywords: Trauma
physical parameter
radiologic examination
Lead sponsor: St. Martin De Porress Hospital
Sponsor class: OTHER
First posted: 2024-01-22
Enrollment: 350
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The multiple trauma patients are sent to emergency room for further evaluation and management.

Brief summary: Collect data about physiological examination values, blood test values and radiological examination results of patients admitted to the hospital for major trauma. There are different causes of mortality in multiple trauma patients. In this study, review the multiple symptoms and parameters of major trauma patients. We hope to understand and develop one feasible assessment model for emergency departments for enable rapid diagnosis and treatment evaluation about major trauma patients occurrence.

Detailed description: 1. This is a retrospective study of patients admitted to the emergency department at a single center, focusing on reviewing their medical records and patient examination performance.
2. The parameters including hospital on-site records and patient examination result, physiological examination values, blood test values and radiological examination results.on the medical records of patients who visited emergency department are collected.
3. This study will explore how to improve the response and effectiveness of investigating patients when they are admitted to the hospital for major trauma.
4. Evaluate the effectiveness and efficiency of this operative model to increase the possibility of receiving medical examination, timely correct diagnosis on major trauma patients when they sent to the emergency department, and improve the hospital's manpower deployment plan.

Eligibility criteria: Inclusion Criteria:multiple trauma patients -

Exclusion Criteria:expired patients at emergency room

-

Primary outcomes:
measure: The Survey of Mortality and Mobility on Multiple Trauma Patients
timeFrame: 20100101 till 20241231
Secondary outcomes:
Other outcomes:
Locations:
city: Chiayi City
country: Taiwan
facility: St. Martin De Porres Hospital
city: Chiayi City
country: Taiwan
facility: St. Martin De Porres Hospital
Study officials:
affiliation: Department of Emergency, St. Martin De Porres Hospital
name: Chia Hsi Chen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03638973: Comparison of Sample Biopsy Using Scalpel or Er:YAG Laser
Official title: Randomized Prospective Study for the Comparison of Sample Biopsy Using Scalpel or Er:YAG Laser
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Laser Burn
Gingival Disease
Biopsy Wound
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2018-08-20
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: For certain changes in the oral mucosa a histopathological examination of the affected tissue is indicated to confirm the diagnosis. The gold standard is the biopsy by scalpel. The aim of this study is to compare the alternative method of tissue sampling using the erbium doped yttrium aluminium garnet (Er:YAG) laser with the gold Standard.

Detailed description: Various parameters are compared, such as the pain intensity during and after the biopsy, the evaluation of the tissue removed by the histopathologist, the occurrence of bleeding during and after the removal and the time required for both therapies.

Patients who agree to participate in the study will be randomized (randomly) to either therapy.

Eligibility criteria: Inclusion Criteria:

* Indication for biopsy of the oral mucosa
* male and female adult patients
* Written consent of the participating persons after clarification

Exclusion Criteria:

* pregnancy
* Taking blood thinners
* Known infectious diseases
* Untreated diabetes mellitus
* Taking immunosuppressants

Primary outcomes:
measure: histological assessability
timeFrame: 13 month
Secondary outcomes:
measure: postoperative pain
timeFrame: 13 month
measure: postoperative bleeding
timeFrame: 13 month
measure: time for removal
timeFrame: 13 month
Other outcomes:
Locations:
city: Zürich
country: Switzerland
facility: Clinic for Oral Surgery, Center of dental medicine, University of Zurich
Study officials:
affiliation: Sponsor GmbH
name: Martin Rücker, Prof.Dr.Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Suter VGA, Altermatt HJ, Bornstein MM. A randomized controlled clinical and histopathological trial comparing excisional biopsies of oral fibrous hyperplasias using CO2 and Er:YAG laser. Lasers Med Sci. 2017 Apr;32(3):573-581. doi: 10.1007/s10103-017-2151-8. Epub 2017 Jan 24.
Clinical trial NCT00139373: Study of the Distractibility Syndrome in Patients With Progressive Supranuclear Palsy
Official title: Study of the Distractibility Syndrome in Patients With Progressive Supranuclear Palsy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Supranuclear Palsy, Progressive
Keywords: Progressive supranuclear palsy
Frontal lobe
Oculomotor testing
Neuropsychological scores
Motor disability (UPDRS)
Distractibility
Lead sponsor: Groupe Hospitalier Pitie-Salpetriere
Sponsor class: OTHER
Collaborators: name: Institut National de la Santé Et de la Recherche Médicale, France
First posted: 2005-08-31
Enrollment: 16
Sex: ALL
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The syndrome of distractibility is a behavioral disorder induced by a lesion or a dysfunction of the frontal lobe. This sign is frequent in patients with progressive supranuclear palsy (PSP), a neurodegenerative disorder with severe neuronal loss in the prefrontal cortex and cholinergic systems, in particular in the Meynert basalis nucleus. This could participate in the occurrence of the distractibility in these patients. The aim of this study is to evaluate the effect of the donepezil, an anticholinesterase, on the distractibility in PSP patients, by using oculomotor and neuropsychological assessments.


Eligibility criteria: Inclusion Criteria:

* Patients with PSP
* Age \> 30 years old
* Disease duration \< 5 years
* Mini mental state (MMS) \> 24
* Antisaccades %: 40-80%

Exclusion Criteria:

* Other parkinsonian syndromes
* MMS \< 24

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Centre d'Investigation Clinique-HÔPITAL PITIÉ-SALPETRIERE
Study officials:
affiliation: INSERM-U679
name: Bertrand Gaymard, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00407173: Study to Evaluate the Effects of Age & Gender on PK, Safety & Tolerability of HCV-796 Administered to Healthy Subjects
Official title: An Open-Label, Single-Dose, Parallel Group Study to Evaluate the Effects of Age and Gender on the Pharmacokinetics, Safety, and Tolerability of HCV-796 Administered Orally to Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Lead sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
Sponsor class: INDUSTRY
Collaborators: name: ViroPharma
First posted: 2006-12-04
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study is an open-label, single-dose, parallel group study to evaluate the effects of age and gender on the pharmacokinetics, safety, and tolerability of HCV-796 administered orally to healthy subjects.


Eligibility criteria: Inclusion:

* Men or nonlactating and nonpregnant women, aged 18 to 45, and \>65 years.
* Men must agree to practice barrier contraception for 12 weeks after the last test article administration.
* Estimated (calculated) creatinine clearance must be within the age-appropriate normal range.

Exclusion:

* History of seizures.
* History of rhabdomyolysis.
* History of thyroid disease.

Primary outcomes:
measure: To evaluate the pharmacokinetic (PK) profile of HCV-796 in healthy men and women of different ages.
timeFrame: 7 days
Secondary outcomes:
measure: To assess the safety and tolerability of a single oral dose of HCV-796 in healthy men and women of different ages.
timeFrame: 15 days
Other outcomes:
Locations:
city: Gainesville
country: United States
state: Florida
city: Philadelphia
country: United States
state: Pennsylvania
Study officials:
affiliation: Wyeth is now a wholly owned subsidiary of Pfizer
name: Medical Monitor
role: STUDY_DIRECTOR
References:
Clinical trial NCT04391673: Factors Affecting Outcome of Vestibular Rehabilitation
Official title: Analysis of Illness Perceptions Affecting the Outcome of Vestibular Rehabilitation
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Chronic Dizziness
Vestibular Disease
Lead sponsor: Guy's and St Thomas' NHS Foundation Trust
Sponsor class: OTHER
First posted: 2020-05-18
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with dizziness and balance disorders.

Brief summary: This is an observational longitudinal study to investigate if negative illness perceptions predict less improvement in dizziness handicap following vestibular rehabilitation. Consecutive patients (n=260) who enter the vestibular rehabilitation programme at Guy's Hospital, London will be included. Questionnaires will be conducted immediately before, and after their final treatment. The main outcome will be the Dizziness Handicap Inventory after rehabilitation.

Detailed description: The aim of this longitudinal study is to investigate whether illness perceptions predict dizziness handicap following a treatment as usual 8-week vestibular rehabilitation programme in patients with chronic vertigo and dizziness.

Participants will be recruited consecutively from patients attending the dizziness and balance exercise programme at Guys \& St Thomas' NHS Foundation Trust. Consenting patients will complete the following questionnaires before and after rehabilitation:

1. The Dizziness Handicap Inventory (DHI)
2. The Illness Perceptions Questionnaire - Revised (IPQ-R)
3. The Patient Health Questionnaire Anxiety and Depression Scale (PHQ-ADS)

The Dizziness Handicap Inventory (DHI) at discharge will be the dependent variable. We will also demographic data including age, gender, and illness type.

Eligibility criteria: Inclusion Criteria:

* are aged above 18 years old and are enrolled onto the vestibular rehabilitation programme due to chronic dizziness

Exclusion Criteria:

* Patients will be excluded if they have evidence of central nervous system disorders or cannot speak English.

Primary outcomes:
measure: Dizziness Handicap Inventory (DHI)
timeFrame: At discharge (final session of physiotherapy), an average of 10 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Guy's & St Thomas' NHS Foundation Trust
Study officials:
affiliation: Guy's and St Thomas' NHS Foundation Trust
name: David Herdman
role: PRINCIPAL_INVESTIGATOR
References: