louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03030443: Patient Preferences in Anesthesia for Abortion Care
Official title: Patient Preferences in Anesthesia for Abortion Care
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pregnancy Termination in First Trimester
Keywords: Pain management
Nitrous
Lead sponsor: University of New Mexico
Sponsor class: OTHER
Collaborators: name: Society of Family Planning
First posted: 2017-01-25
Enrollment: 29
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women undergoing first trimester surgical abortion choosing between oral anesthesia and nitrous oxide. All patients will be English-speaking women who are 18 years old or older.

Brief summary: This study will use semi-structured interviews with participants in a prospective cohort study to explore women's experiences of pain and preferences in pain management during first trimester surgical abortion to create a more patient centered experience. We will analyze two study cohorts of women undergoing first trimester surgical abortion: women choosing oral anesthesia and women choosing nitrous oxide.

Detailed description: This study will utilize an open-ended semi-structured interview format to elicit a broader understanding of the multi-dimensional pain experience of woman undergoing an abortion procedure. This study seeks to provide further evaluation of the pain experience and preferences of women receiving alternative methods of pain management such as oral sedation and nitrous oxide.

The study will use semi-structured interviews to explore women's experiences of pain and preferences in pain management during first trimester surgical abortion and will include a procedural pain outcome using the visual analog scale (VAS) to create a more patient centered experience.

Eligibility criteria: Inclusion Criteria:

* women undergoing first trimester surgical abortion choosing between oral anesthesia or nitrous oxide for pain management
* women who are able to read and understand English
* women who are 18 years old or older

Exclusion Criteria:

* under the age of 18
* women unable to consent and/or are cognitively impaired
* women who are incarcerated
* women who do not speak English

Primary outcomes:
measure: Identify Patient Priorities and Preferences for pain and pain management through Qualitative Analysis
timeFrame: through patient completion in study, up to one week following the procedure
Secondary outcomes:
measure: Compare quantitative and qualitative assessment of pain
timeFrame: through patient completion in study, up to one week following the procedure
Other outcomes:
Locations:
city: Albuquerque
country: United States
facility: University of New Mexico
state: New Mexico
Study officials:
affiliation: University of New Mexico Health Sciences Center
name: Rameet Singh, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03082443: Group Intervention in the Nutritional Profile, Stress and Quality of Life in Patients in Cardiopulmonary Rehabilitation
Official title: The Effectiveness of a Group Intervention in the Nutritional Profile, Stress and Quality of Life in Patients in Cardiopulmonary Rehabilitation: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Stress
Quality of Life
Nutritional Status
Keywords: Cardiac rehabilitation
psychology
nutrition
stress
quality of life
Lead sponsor: Instituto de Cardiologia do Rio Grande do Sul
Sponsor class: OTHER
First posted: 2017-03-17
Enrollment: 116
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: To evaluate the effectiveness of a group intervention in the nutritional profile, in the stress and in the quality of life of patients in cardiopulmonary rehabilitation. Method: Randomized clinical trial using a semi-structured interview, sociodemographic and anthropometric data collection, with 164 participants divided into a control group and intervention group, the Food Frequency Questionnaire, the Lipp Adult Stress Symptom Inventory (ISSL) ) And the SF-12 Quality of Life Assessment Questionnaire. To verify the difference in nutritional profile, stress levels and quality of life between the groups, the chi-square test will be used for categorical variables and within each group the comparison between the moments will be through the MC Nemar test. In the quantitative variables the evaluation of the interaction between group and time will be through Variance Analysis using the design in Repeated Measures. Considering a significance level p \<0.05. Expected Results: It is believed that psychological and nutritional intervention in patients participating in therapeutic groups helps them to elaborate questions regarding the difficulties of coping with the disease in the daily routine and to understand the importance of lifestyle care and healthy habits.


Eligibility criteria: Inclusion Criteria:

* Cardiopathy patients over 18 years of age, users of the Center for Cardiopulmonary and Metabolic Rehabilitation of the Cardiology Institute who signed the Term of Free and Informed Consent

Exclusion Criteria:

* Patients not able to respond to questionnaires at the time of application. Patients who do not want to continue responding to the survey.

Primary outcomes:
measure: Number of participants in a therapeutic group of patients in cardiac rehabilitation evaluated for stress
timeFrame: Six weeks
measure: Number of participants in a therapeutic group of patients in cardiac rehabilitation evaluated for quality of life
timeFrame: Six weeks
measure: Number of participants in a therapeutic group of patients in cardiac rehabilitation evaluated for nutritional profile
timeFrame: Six weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00802581: Circumferential Spread of Anesthetic and Success in Sciatic Nerve Blockade
Official title: Does Ensuring Circumferential Local Anesthetic Spread Improve the Success of Ultrasound Guided Sciatic Nerve Block at the Popliteal Fossa?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sciatic Nerve Blockade for Foot/Ankle Surgery
Keywords: sciatic nerve block
local anesthetic
lidocaine
ankle surgery
foot surgery
ultrasound-guided regional anesthesia
circumferential spread
anesthetic infiltration
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
First posted: 2008-12-05
Enrollment: 64
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Current practices when performing any peripheral nerve block may or may not involve ensuring circumferential spread of local anesthetic around the nerve. Ensuring circumferential spread can involve several redirections of the needle above and below the nerve, and potentially could result in either more discomfort for the patient or an increased chance of inadvertent direct trauma to the nerve. Not ensuring spread around the nerve may result in a slower and less complete blockade. The investigators suspect that by ensuring complete spread around the nerve, the speed of block onset would be quicker because it avoids the loss due to diffusion time.


Eligibility criteria: Inclusion Criteria:

1. English-speaking
2. ASA physical status I-III
3. 18-85 years of age, inclusive
4. 50-110 kg, inclusive
5. 150 cm of height or grater
6. Scheduled for elective foot or ankle surgery

Exclusion Criteria:

1. Contraindications to sciatic nerve block (e.g., allergy to local anesthetics, coagulopathy, malignancy or infection in the popliteal area)
2. Significant peripheral neuropathy or neurologic disorder affecting the lower extremity
3. Pregnancy
4. Contraindications to, allergies to, and/or past adverse reactions to study medications (local anesthetics, opioid analgesics)
5. History of alcohol or drug dependency/abuse
6. History of long term opioid intake
7. History of significant psychiatric conditions that may affect patient assessment

Primary outcomes:
measure: Onset time of sciatic nerve blockade.
timeFrame: Every 5 minutes for 30 minutes after anesthetic injection
Secondary outcomes:
measure: Block success, time required to perform block, complications/adverse events, number of needle passes, patient discomfort
timeFrame: 24 hours
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Toronto Western Hospital
state: Ontario
Study officials:
affiliation: University Health Network, Toronto
name: Richard Brull, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00234481: Safety Study of XL844 in Subjects With Chronic Lymphocytic Leukemia
Official title: A Phase 1 Dose-Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of XL844 Administered Orally to Subjects With Chronic Lymphocytic Leukemia
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE1
Conditions: Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma
Lead sponsor: Exelixis
Sponsor class: INDUSTRY
First posted: 2005-10-07
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the safety and tolerability of different doses of XL844 when given orally to adults with recurrent or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.


Eligibility criteria: Inclusion Criteria:

* Patients with recurrent or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)
* Prior treatment with at least 2 systemic chemotherapy regimens for CLL
* Life expectancy of \>3 months
* Adequate liver and kidney function
* Absolute neutrophil count ≥500/mm3; platelets ≥50,000/dL; hemoglobin ≥9 g/dL
* Willing to use accepted method of contraception during the course of the study
* Negative pregnancy test (females)
* Written informed consent

Exclusion Criteria:

* Chemotherapy or radiotherapy within 4-6 weeks of the start of treatment (depending on the therapy)
* Investigational drug within 30 days of the start of treatment
* Uncontrolled intercurrent illness such as infection or cardiovascular disease
* Pregnant or breastfeeding women
* Subjects known to be HIV positive

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Duarte
country: United States
facility: City of Hope National Cancer Center
state: California
city: San Diego
country: United States
facility: UCSD Moores Cancer Center
state: California
city: Houston
country: United States
facility: UT MD Anderson Cancer Center
state: Texas
Study officials:
References:
Clinical trial NCT01381081: Platelet-rich Plasma Intra-articular Knee Injections for Knee Osteoarthritis
Official title: A Prospective, Randomized, Double-blinded, Clinical Trial, Comparing Platelet-rich Plasma Intra-articular Knee Injections Versus Corticosteroid Intra-articular Knee Injections for Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Knee Osteoarthritis
Keywords: knee osteoarthritis
comparing platelet-rich plasma
intra-articular knee injections
Lead sponsor: Hospital Universitari Vall d'Hebron Research Institute
Sponsor class: OTHER
First posted: 2011-06-27
Enrollment: 74
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The benefit of using platelet rich plasma (PRP) in cartilage injuries, and specifically in degenerative ones, has not been assessed yet. Current studies on the PRP healing or repairing effect on knee cartilage degenerative injuries are not conclusive to establish a standard of behavior, although PRP has shown to improve joint functionality and reduce pain.

Hypothesis: PRP intra-articular injections in osteoarthritic knees reduces pain and leads to a more effective and lasting functional recovering than corticosteroid intra-articular injections.


Eligibility criteria: Inclusion Criteria:

* Degenerative osteoarthritis of the knee confirmed radiologically
* Degenerative osteoarthritis of the knee replacement candidate
* Walking ability in patients with or without external support
* Baseline in pain VAS greater than 60

Exclusion Criteria:

* Neoplastic disease
* Immunosuppressive States
* Patients who received intra-articular injections of steroids, anesthetic and / or hyaluronic acid in the last 3 months.
* Patients who have undergone arthroscopic surgery on the last 3 months
* Patients with involvement of bone metabolism except osteoporosis (Paget's disease, renal osteodystrophy, osteomalacia)
* Fibromyalgia or chronic fatigue syndrome
* Liver disease
* Deficit coagulation (blood dyscrasia)
* Thrombocytopenia
* Anticoagulant treatment

Primary outcomes:
measure: The value of the visual analogue scale pain (VAS)
timeFrame: one month after the treatment
Secondary outcomes:
measure: the value of pain visual analog scale according to
timeFrame: 4 weeks, 3 and 6 months after treatment
measure: the functional level of the knee KOOS
timeFrame: 4 weeks, 3 and 6 months after treatment
measure: All reported adverse events
timeFrame: 4 weeks, 3 and 6 months after treatment
measure: Scale of the SF36 quality of life
timeFrame: 4 weeks, 3 and 6 months after treatment
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Hospital Universitario Vall d'Hebron
Study officials:
affiliation: Hospital Vall d'Hebron
name: Nayana Joshi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01017081: Chest Physiotherapy in Pediatrics Patients With Pneumonia
Official title: Chest Physiotherapy in Pediatric Patients Hospitalised With Community-acquired Pneumonia: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pneumonia
Keywords: physiotherapy
children
clinical trial
Lead sponsor: Santa Casa de Porto Alegre
Sponsor class: OTHER
Collaborators: name: Federal University of Rio Grande do Sul
First posted: 2009-11-20
Enrollment: 72
Sex: ALL
Minimum age (years): 1
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Chest physiotherapy has been used to treat pediatric patients hospitalized with pneumonia however there was no evidence to support a beneficial effect in pediatric patients.


Eligibility criteria: Inclusion Criteria:

* Children aged 1 to 12 years with acute community-acquired pneumonia (cough, tachypnea, fever and with a chest radiography with lobar, segmental or bronchopneumonia within the first 48 hours)

Exclusion Criteria:

* Severely ill patients (hospitalized in intensive care units)
* Pleural effusion treated with chest drainage
* Atelectasis detected by x-ray
* Pneumonia or pleural effusion in the previous six months
* Other pulmonary underlying disease, heart disease, cerebral palsy or immune deficiency

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Posto Alegre
country: Brazil
facility: Santa Casa de Porto Alegre
state: Rio Grande do Sul
Study officials:
References:
Clinical trial NCT03745781: Open-Label Placebo for Functional Dyspepsia
Official title: Open-Label Placebo for Functional Dyspepsia
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: EARLY_PHASE1
Conditions: Dyspepsia
Lead sponsor: Beth Israel Deaconess Medical Center
Sponsor class: OTHER
First posted: 2018-11-19
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Arm 1: open-label placebo Arm 2: treatment as usual control
Primary purpose: TREATMENT

Brief summary: The study is evaluating the efficacy of open-label placebo for the treatment of functional dyspepsia.


Eligibility criteria: Inclusion Criteria:

* Functional Dyspepsia

Exclusion Criteria:

-

Primary outcomes:
measure: dyspepsia severity on a VAS from 0-100
timeFrame: 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center
state: Massachusetts
Study officials:
References:
Clinical trial NCT03004781: Stimulation of Parents' Self-efficacy Beliefs and Emotion Coaching Practices (H2M1)
Official title: Stimulation of Parents' Self-efficacy Beliefs and Emotion Coaching Practices to Reduce Externalizing Behavior in Preschoolers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Behavior Problem
Keywords: parenting intervention
externalizing behavior
emotion coaching practices
self-efficacy beliefs
Lead sponsor: Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2016-12-29
Enrollment: 45
Sex: ALL
Minimum age (years): 3
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This research compared the efficacy of two parenting interventions that vary according to the number and the nature of variables in reducing preschoolers' externalizing behavior (EB). The goal was to identify which parenting intervention format (one-variable versus two-variable) caused higher behavioral adjustment in children.

Detailed description: The first format was a one-variable intervention manipulating parental self-efficacy beliefs. The second format was a two-variable intervention manipulating both parents' self-efficacy beliefs and emotion coaching practices. The two interventions shared exactly the same design, consisting of eight parent group sessions. Effect on children's EB and observed behaviors were evaluated through a multi-method assessment at three points (pre-test, post-test and follow-up).

Eligibility criteria: Inclusion Criteria:

* children in the clinical or borderline range of the EB scale (cut-off = 21 or higher) of the Child Behavior Checklist preschool form (Achenbach \& Rescorla, 2000a)
* three to six years old and still in kindergarten at the beginning of the intervention

Exclusion Criteria:

* children with intellectual disabilities (average IQ \< 5.5)
* highly gifted children (average IQ \>14.5)

Primary outcomes:
measure: Change in child behavior
timeFrame: 0 week, 8 weeks, 24 weeks
Secondary outcomes:
measure: Change in parental self-efficacy beliefs
timeFrame: 0 week, 8 weeks, 24 weeks
measure: Change in parenting behavior
timeFrame: 0 week, 8 weeks, 24 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05797181: The Effect Of Medical Nutritional Therapy On Patients With Sarcopenic Obesity Receiving Peritoneal Dialysis Treatment
Official title: The Effect of Medical Nutrition Therapy on Anthropometric Measurements and Blood Parameters in Sarcopenic Obesity Patients Receiving Peritoneal Dialysis Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Peritoneal Dialysis Complication
Sarcopenic Obesity
Lead sponsor: Atlas University
Sponsor class: OTHER
First posted: 2023-04-04
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: In this study, it was aimed to evaluate the effectiveness of medical nutrition therapy to be applied to patients with sarcopenic obesity receiving peritoneal dialysis treatment by measuring anthropometric measurements and blood parameters.

Detailed description: Efficacy of medical nutrition therapy in patients with sarcopenic obesity receiving peritoneal dialysis treatment, general information form after patients filled in the voluntary consent form, SARC-F questionnaire as sarcopenia screening test, International Physical Activity Questionnaire (IPAQ), muscle mass, muscle strength, physical performance, BIA measurement, anthropometric measurements, laboratory findings and three-day food consumption records will be evaluated.

Eligibility criteria: Inclusion Criteria:

* Volunteering to participate in research
* Be between the ages of 18-70
* To receive peritoneal dialysis treatment and to come to the hospital regularly once a month for treatment

Exclusion Criteria:

* Presence of any other disease that causes muscle wasting
* Patients using any supplement or enteral product in their diet

Primary outcomes:
measure: Change in muscle strength
timeFrame: Baseline to 3 months after diet programme
measure: Change in the skeletal muscle mass
timeFrame: Baseline to 3 months after diet programme
measure: Change in the physical performance
timeFrame: Baseline to 3 months after diet programme
measure: Change of the fat mass
timeFrame: Baseline to 3 months after diet programme
measure: Changes of percentage of body fat
timeFrame: Baseline to 3 months after diet programme
measure: Changes of body mass index
timeFrame: Baseline to 3 months after diet programme
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Marmara University
Study officials:
affiliation: Atlas University
name: Ayşe Betül Demirbaş
role: PRINCIPAL_INVESTIGATOR
References: