Clinical trial NCT03274869: Scrub Typhus Infection Induced Cardiovascular Disease
Official title: Prediction and Early Diagnosis for Cardiovascular Disease Complicated by Scrub Typhus Infection
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Scrub Typhus
Cardiovascular Complication
Keywords: Scrub typhus
Cardiovascular Complication
Lead sponsor: Eulji University Hospital
Sponsor class: OTHER
Collaborators: name: Chung-Ang University Hosptial, Chung-Ang University College of Medicine
name: Chungbuk National University Hospital
First posted: 2017-09-07
Enrollment: 100
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Scrub typhus infection without cardiovascular complication Scrub typhus infection with cardiovascular complication

Brief summary: Scrub typhus infection has been considered as seasonal and endemic infectious disorder with benign feature. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia and cause of death could be a fetal complicating cardiovascular disease. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection.

Detailed description: Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi confined to East Asia including South Korea. It is characterized by fever, headache, rash, and eschar and the majority of patients without complications can recover with an early diagnosis and proper management with antibiotics. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia. Severe complications can be manifested by respiratory distress syndrome, renal failure, hepatic failure, and cardiovascular disease. Especially, cardiovascular complications can lead to cardiogenic shock and sudden cardiac arrest. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection admitted to 3rd referral centers in South Korea.

Eligibility criteria: Inclusion Criteria:

* any participants with scrub typhus infection

Exclusion Criteria:

* patients under age of 18
* pregnancy

Primary outcomes:
measure: Cardiovascular Mortality
timeFrame: one year
Secondary outcomes:
measure: Cardiovascular Complications
timeFrame: one year
Other outcomes:
Locations:
city: Chungju
country: Korea, Republic of
facility: Chung-Buk University Hospital
state: Chung Chung Do
city: Daejeon
country: Korea, Republic of
facility: Chung-Nam University Hospital
state: Chung Chung Do
Study officials:
affiliation: Chung-Ang University Hosptial, Chung-Ang University College of Medicine
name: Hyu Ryung Cho
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chin JY, Kang KW, Moon KM, Kim J, Choi YJ. Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. Korean J Intern Med. 2018 Mar;33(2):323-330. doi: 10.3904/kjim.2016.303. Epub 2017 Feb 23.
citation: Jang SY, Kang KW, Kim JH, Kim B, Chin JY, Park SH, Choi YJ, Jung KT, Lee SK. New-onset atrial fibrillation predicting for complicating cardiac adverse outcome in scrub typhus infection. Clin Cardiol. 2019 Dec;42(12):1210-1221. doi: 10.1002/clc.23276. Epub 2019 Oct 3.
citation: Kang KW, Hong KW, Lee SK. Identification of novel variants for complicating cardiac disease in the scrub typhus infection using whole genome sequencing. Korean J Intern Med. 2023 Nov;38(6):865-871. doi: 10.3904/kjim.2023.221. Epub 2023 Nov 1.