Clinical trial NCT03797638: Characterization of Manual Dexterity by Finger Force Manipuladum (FFM) in Patients With Writer's Cramp and in Control Subjects
Official title: Characterization of Manual Dexterity by Finger Force Manipuladum (FFM) in Patients With Writer's Cramp and in Control Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dystonic Disorder
Focal Dystonia
Writer's Cramp
Keywords: Dystonic Disorder
Focal Dystonia
Writer's Cramp
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
Collaborators: name: Institut National de la Santé Et de la Recherche Médicale, France
First posted: 2019-01-09
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Writer's cramp is a focal dystonia characterized by abnormal movements and postures during writing. Limited finger independence during writing manifests as difficulty suppressing unwanted activations of neighbouring non task-relevant fingers. Patients with Writer's cramp also have difficulty in fine control of grip force.

The investigators have recently developed the Finger Force Manipulandum which quantifies the forces applied by each fingers in different tasks. This method is sensitive for detection and quantification of small unwanted contractions in non-active ('stationary') fingers. Different tasks have been developed to assess abilities such as finger individuation but also fine finger force control, finger movement regularity and speed.

The aim of this study is to assess if developed tasks allow to precisely characterize writer's cramp condition in terms of abilities aforementioned.

To do so, performance of 20 writer's cramp patients in the developed task will be compared with performance of 20 control participants (matched in age, sex and writing hand) in the same tasks.


Eligibility criteria: Inclusion criteria for patients with writer's cramp

* Patient with writer's cramp and writing speed \<140 letters / min
* Writer's cramp focal dystonia specific to the task of writing
* Patient treated or not with botulinum toxin injection
* Person having attended school in French

Non inclusion criteria for patients with writer's cramp

* Patients whose writer's cramp has no impact on the handwriting and has kept a writing speed\> 140 letters per minute.
* Tremor of writing
* Neurological condition other than writer's cramp (eg Parkinson's syndrome)
* Pain, trauma or pathology of the upper limb of the writing member other than the writer's cramp who required medical or surgical treatment in the last 6 months preceding the initial check-up

Inclusion criteria for control subjects

•\> 18 years old

* Without writer's cramp
* Person having attended school in French

Non inclusion criteria for control subjects

* Tremor of writing
* Neurological condition other than writer's cramp (eg Parkinson's syndrome)
* Pain, trauma or pathology of the upper limb of the writing member other than the writer's cramp who required medical or surgical treatment in the last 6 months preceding the initial check-up

Matching criteria between cases and control patients

* Age (± 5 years)
* Gender
* Hand writing

Primary outcomes:
measure: Manual dexterity by the FFM
timeFrame: Inclusion
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Fondation A de Rothschild
Study officials:
affiliation: Fondation A. de Rothschild
name: Jean-Pierre BLETON, PhD
role: PRINCIPAL_INVESTIGATOR
References: