louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04188210: Elbow Pain in Hemodialysis Patients and Its Effect on Daily Living Activities of the Patients
Official title: Elbow Pain in Hemodialysis Patients and Its Effect on Daily Living Activities of the Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: End Stage Renal Disease
Keywords: musculoskeletal pain
elbow pain
hemodialysis
Lead sponsor: Namik Kemal University
Sponsor class: OTHER
First posted: 2019-12-05
Enrollment: 135
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: the patients with end stage renal disease

Brief summary: The study will include the patients undergoing hemodialysis.

Detailed description: The study will include the patients undergoing hemodialysis. The patients with surgery at upper extremity in last 3 months, the presence of conditions such as cancer, chronic hearing loss and neurologic diseases affect the interview will be excluded. Sociodemographic properties which include age, gender, duration of dialysis, educational level, comorbid diseases, vascular access area, hand dominancy will be asked. The Beck Depression Inventory (BDI), the Nottingham Health Profile (NHP), the Disabilities of the Arm, Shoulder and Hand Score (Q-DASH) and Visual Analogue Scale (VAS) will applied to all patients.

All the demographic results and vascular access area for hemodialysis will be detected. All data for normality will be tested by using Kolmogorov-Smirnov test. To compare the differences between groups, Mann Whitney U test will be used

Eligibility criteria: Inclusion Criteria:

* being over 18 years old having hemodialysis treatment

Exclusion Criteria:

* any surgical operation at upper extremity in last 3 months, the presence of conditions such as cancer, chronic hearing loss and neurologic diseases can affect the interview.

Primary outcomes:
measure: Kolmogorov-Smirnov test
timeFrame: through study completion, an average of 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Kırklareli
country: Turkey
facility: Private Balkan Hospital
Study officials:
affiliation: private balkan hospital
name: betül tepeli
role: PRINCIPAL_INVESTIGATOR
References:
citation: Fidan F, Alkan BM, Tosun A, Altunoglu A, Ardicoglu O. Quality of life and correlation with musculoskeletal problems, hand disability and depression in patients with hemodialysis. Int J Rheum Dis. 2016 Feb;19(2):159-66. doi: 10.1111/1756-185X.12171. Epub 2013 Oct 31.
citation: Kane SF, Lynch JH, Taylor JC. Evaluation of elbow pain in adults. Am Fam Physician. 2014 Apr 15;89(8):649-57.
Clinical trial NCT02381210: Diagnosis and Prediction of Pre-Eclampsia by Using Congo Red Dot Test in Bangladesh and Mexico
Official title: Diagnosis and Prediction of Preeclampsia: A Case Control Study of the Clinical Utility of Congo Red Dot Test in Bangladesh and Mexico
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Preeclampsia
Keywords: Congo Red Dot Test
Lead sponsor: Gynuity Health Projects
Sponsor class: OTHER
Collaborators: name: Nationwide Children's Hospital
First posted: 2015-03-06
Enrollment: 400
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women attending Dhaka Medical College Hospital and Hospital Materno-Infantil Inguarán with clinically confirmed cases of preeclampsia and clinically healthy women who deliver at term will be eligible for the study.

Brief summary: A cross sectional study design will evaluate the diagnostic value of the CRD test to the pregnant women attending the Dhaka Medical College Hospital and Hospital Materno-Infantil Inguarán, tertiary level facilities in Bangladesh and Mexico City.

Detailed description: A cross sectional study design will evaluate the diagnostic value of the Congo Red Dot test to the pregnant women attending the Dhaka Medical College Hospital and Hospital Materno-Infantil Inguarán, tertiary level facilities in Bangladesh and Mexico City. Women attending the hospital with clinically confirmed cases of preeclampsia and clinically healthy women who deliver at term will be eligible for the study. Investigators will enroll about 200 women at each facility. Investigators will target the following women for enrollment: women with clinical diagnosis of preeclampsia (severe, mild or superimposed) (n=100); and clinically healthy women who deliver at term (n=100). The purpose of the research is to determine the clinical utility of congophilia (affinity for the dye Congo Red) in the diagnosis and prediction of preeclampsia. Investigators will determine the diagnostic value of this test by testing the urine sample provided to determine the presence or absence of proteinuria or congophilia.

Eligibility criteria: Inclusion Criteria:

* Pregnant
* Willing to provide a urine sample
* Eligible to consent to research according to local laws and regulations
* Present with a clinical diagnosis of preeclampsia (severe, mild or superimposed) OR clinically healthy and delivering at term

Exclusion Criteria:

-None

Primary outcomes:
measure: Prevalence of urine congophilia using Congo Red Dot test
timeFrame: within 1 month of urine sample collection
Secondary outcomes:
Other outcomes:
Locations:
city: Dhaka
country: Bangladesh
facility: Dhaka Medical College
city: Mexico City
country: Mexico
facility: Hospital Materno-Infantil Inguarán
Study officials:
affiliation: Nationwide Children's Hospital
name: Irina Buhimschi, Dr
role: PRINCIPAL_INVESTIGATOR
affiliation: Gynuity Health Projects
name: Beverly Winikoff, Dr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00005710: Recycling of Chronic Smokers to Sustained Abstinence
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Diseases
Heart Diseases
Lung Diseases
Lead sponsor: University of Minnesota
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2000-05-26
Sex: MALE
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: To develop and to test a brief telephone intervention following clinic treatment for smoking cessation.

Detailed description: DESIGN NARRATIVE:

A total of 1,083 chronic smokers were randomly assigned either to a traditional state-of-the-art smoking cessation clinic or to the clinic supplemented by telephone support for recycling. Telephone outreach consisted of three separate rounds of intervention three months, nine months, and 21 months after the targeted date for quitting in the smoking cessation clinics.

Telephone calls to abstinent subjects reinforced success and offered advice and support in coping with difficult situations. Calls to relapsers and nonabstainers debriefed concerning the relapse episode (as appropriate) and encouraged subjects to initiate concrete action toward quitting including setting a quit date. Subjects were offered self-help materials as well as referrals to more intensive programs.

Follow-up data collection was separate from recycling contacts and occured six, 12, 24, and 34 months after the initial smoking cessation clinics. Projected longterm sustained abstinence rates were 35 percent for recycling and 25 percent for the clinic only comparison. If results were as predicted, an effective low-cost telephone outreach protocol was made available that could dramatically assist in smoking cessation and thereby substantially reduce cardiovascular disease.

Eligibility criteria: No eligibility criteria

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Roski J, Schmid LA, Lando HA. Long-term associations of helpful and harmful spousal behaviors with smoking cessation. Addict Behav. 1996 Mar-Apr;21(2):173-85. doi: 10.1016/0306-4603(95)00047-x.
citation: Lando HA, Pirie PL, Roski J, McGovern PG, Schmid LA. Promoting abstinence among relapsed chronic smokers: the effect of telephone support. Am J Public Health. 1996 Dec;86(12):1786-90. doi: 10.2105/ajph.86.12.1786.
citation: Lichtenstein E, Glasgow RE, Lando HA, Ossip-Klein DJ, Boles SM. Telephone counseling for smoking cessation: rationales and meta-analytic review of evidence. Health Educ Res. 1996 Jun;11(2):243-57. doi: 10.1093/her/11.2.243.
Clinical trial NCT06038110: Use of Axillary Ultrasound to Guide Breast Cancer Management in the Genomic Assay Era
Official title: Use of Axillary Ultrasound to Guide Breast Cancer Management in the Genomic Assay Era: A Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Axillary Ultrasound
Lead sponsor: KK Women's and Children's Hospital
Sponsor class: OTHER_GOV
First posted: 2023-09-14
Enrollment: 150
Sex: FEMALE
Minimum age (years): 21
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Breast cancer patients with T1-3, HR-positive and HER2-negative disease, aged≥ 50 years old, had axillary ultrasound prior to operation and axillary lymph node dissection

Brief summary: The investigators aimed to determine if axillary ultrasound can reliably distinguish between patients with limited or high nodal burden, so that the patients with limited nodal burden can potentially avoid chemotherapy and instead receive upfront surgery followed by gene assay testing.


Eligibility criteria: Inclusion Criteria:

* breast cancer patients with T1-3, HR-positive and HER2-negative disease.
* aged≥ 50 years old
* had axillary ultrasound prior to operation
* axillary lymph node dissection

Exclusion Criteria:

* Patients with neoadjuvant chemotherapy
* bilateral cancers

Primary outcomes:
measure: the number of abnormal nodes on ultrasound
timeFrame: from the date of diagnosis to the date of surgery, up to 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: KK Women's and Children's Hospital
Study officials:
References:
Clinical trial NCT00563810: Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of MYO-029
Official title: An Ascending Multiple Dose Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MYO-029 Administered Intravenously as a 30-Minute Infusion to Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Keywords: Adult
Aged
Lead sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
Sponsor class: INDUSTRY
First posted: 2007-11-26
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This is a multiple dose study assessing the safety, tolerability, pharmacokinetics and pharmacodynamics of an investigational new drug.


Eligibility criteria: Inclusion Criteria:

* Men aged 18 to 45 years inclusive on study day 1.
* Elderly men and women aged 65 to 80 years inclusive on study day 1.
* Women must be postmenopausal for \> or = 1 year (with estradiol \< 25 pg/mL and an FSH \> 40 mIU/mL).
* Healthy as determined by the investigator on the basis of medical history, physical examination, vital signs, clinical laboratory test results, and 12-leave electrocardiogram.
* Elderly subjects may have stable, nonclinically significant abnormalities on physical examination, and laboratory evaluation.
* Non-smoker.

Primary outcomes:
measure: To assess safety and tolerability.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Wyeth is now a wholly owned subsidiary of Pfizer
name: Medical Monitor
role: STUDY_DIRECTOR
References:
Clinical trial NCT05533710: Comparison Between Erector Spinae Plane Block and Transversus Abdominis Plane Block on Postoperative Analgesia After Total Abdominal Hysterectomy
Official title: Comparative Study Between Bilateral Ultrasound-Guided Erector Spinae Plane Block Versus Bilateral Ultrasound-Guided Transversus Abdominis Plane Block on Postoperative Analgesia After Total Abdominal Hysterectomy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Uterine Diseases
Keywords: ESPB, TAP
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2022-09-09
Enrollment: 40
Sex: FEMALE
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to compare the ultrasound-guided bilateral erector spinae block versus the ultrasound-guided bilateral transversus abdominis plane block on postoperative analgesia after total abdominal hysterectomy.


Eligibility criteria: Inclusion Criteria:

1. Patients American Society of Anesthesiologists physical status (ASA) I and II.
2. Female sex.
3. Age between 40 to 60 years old.
4. Scheduled for elective total abdominal hysterectomy surgeries.

Exclusion Criteria:

1. Patient's refusal.
2. Patients who received long-acting opioids preoperatively.
3. Patients with bleeding disorders and coagulopathy.
4. Infection at the injection site.
5. Allergy to local anesthetics.
6. Patients with significant cognitive dysfunction.
7. Patients with diabetic neuropathy.
8. Patients with uncontrolled hypertension or diabetes.
9. Patients with advanced cardiac, respiratory, hepatic or renal disease.
10. Patients with viral hepatitis or HIV.
11. Surgeries which have been complicated or prolonged (more than 150 mins).

Primary outcomes:
measure: Total morphine consumption
timeFrame: 24 hours postoperative
measure: Visual Analog Scale Score
timeFrame: 24 hours postoperative
measure: The time for first call rescue analgesia
timeFrame: 24 hours postoperative
Secondary outcomes:
measure: Patient satisfaction
timeFrame: 24 hours postoperative
measure: Recognize the adverse effects
timeFrame: 24 hours postoperative
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University
Study officials:
affiliation: Ain Shams University
name: ossama mansour, professor
role: STUDY_CHAIR
References:
Clinical trial NCT04385212: Outcomes in Hospitalized Older Patients With COVID-19
Official title: COVIDAge Study- Hospital Des Trois-Chêne
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronavirus Infection
Sars-CoV2
Elderly Infection
Old Age; Debility
Lead sponsor: University Hospital, Geneva
Sponsor class: OTHER
First posted: 2020-05-12
Enrollment: 230
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All the patients hospitalized in our geriatrics department with Sars-Cov-2 infection

Brief summary: In December 2019, the first patients infected with the 2019 novel coronavirus (2019-nCoV) were diagnosed in Wuhan. The clinical presentation and course of Severe Acute Respiratory Syndrome-CoV-2 (SARS-CoV-2) infection is poorly understood in older patients and is certainly different from the general population. This project is designed to better understand and to determine clinical, biological and radiological markers of poor adverse outcomes in hospitalized older patients diagnosed with COVID-19.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of COVID-19, defined by a positive polymerase chain reaction (PCR) test for SARS-CoV-2 detection, obtained by a nasopharyngeal swab or sputum sample.
* Or patients with negative virus detection in the PCR test, but with a high clinical suspicion will also be considered with COVID-19.

Exclusion Criteria:

- Presence of document indicating a refusal to participate in a research study.

Primary outcomes:
measure: To evaluate the relative contributions of comorbidities on intra-hospitalized death
timeFrame: 1 month
Secondary outcomes:
measure: To evaluate the relative contributions of functional characteristics on intra-hospitalized death
timeFrame: 1 month
measure: To explore specific clinical profiles that may influence COVID-19 disease outcomes in the elderly based on geriatrics syndromes
timeFrame: 1 month
Other outcomes:
Locations:
city: Geneva
country: Switzerland
facility: Department of Rehabilitation and Geriatrics
Study officials:
References:
Clinical trial NCT06986512: Rapid Detection of Pseudomonas Aeruginosa in Bronchoalveolar Lavage Fluid Using Label-free Single-particle Imaging Technology and Assessment of Post-treatment Efficacy in Patients With Pseudomonas Aeruginosa Infection
Official title: Rapid Detection of Pseudomonas Aeruginosa in Bronchoalveolar Lavage Fluid Using Label-free Single-particle Imaging Technology and Assessment of Post-treatment Efficacy in Patients With Pseudomonas Aeruginosa Infection
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Rapid Detection
Pseudomonas Aeruginosa Infection
Lead sponsor: The First Affiliated Hospital with Nanjing Medical University
Sponsor class: OTHER
First posted: 2025-05-23
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Suspected or diagnosed patients with pulmonary infection caused by Pseudomonas aeruginosa

Brief summary: The aim of this study is to observe specimens of bronchoalveolar lavage fluid from patients using a reflection enhanced dark-field scattering microscopy. By observing parameters such as the size, morphology, scattering intensity, and movement speed of pathogens, combined with the clinical characteristics of patients, a rapid diagnosis of Pseudomonas aeruginosa infection can be made. At the same time, the bronchoalveolar lavage fluid samples of patients infected with Pseudomonas aeruginosa before and after treatment were compared, and the quantity and vitality of Pseudomonas aeruginosa were observed to judge the efficacy of antibiotics.


Eligibility criteria: Inclusion Criteria:

* Aged 18 years and above
* After admission, Pseudomonas aeruginosa was cultured in bronchoalveolar lavage fluid or lower respiratory tract aspirates

Exclusion Criteria:

* Age under 18 years old or over 90 years old
* Pregnancy, lactation period -

Primary outcomes:
measure: The size of pathogens
timeFrame: From enrollment to the end of treatment at 2 weeks
measure: scattering intensity of pathogen
timeFrame: From enrollment to the end of treatment at 2 weeks
measure: movement speed of pathogens
timeFrame: From enrollment to the end of treatment at 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Nanjing
country: China
facility: The First Affiliated Hospital of Nanjing Medical University
state: Jiangsu
Study officials:
References:
Clinical trial NCT00153712: Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers
Official title: A Prospective Cohort Study to Study the Natural History and Ulcer Recurrence Without Acid Suppression of Non-NSAID, Non-HP Bleeding Peptic Ulcer Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Peptic Ulcer
Keywords: Non-NSAID
Non-Hp Bleeding Peptic Ulcer
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2005-09-12
Enrollment: 391
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All peptic ulcer bleeding patients

Brief summary: The aim of this study is to study the natural history of the ulcer healing while on proton pump inhibitors (PPI) and the ulcer recurrence without acid suppression therapy of Non-steroidal Anti-inflammatory Drugs (NSAID), non-Helicobacter pylori (HP) bleeding ulcer patients.

Detailed description: Non-steroidal Anti-inflammatory Drugs (NSAID), Non-Helicobacter pylori (HP) bleeding peptic ulcers are relatively common in the West (11%-44%). It is uncommon in Hong Kong (4%). Significant number of these patients with non-NSAID, non-Hp bleeding ulcers had co-morbid illness and many had life-threatening conditions. Our recent study showed that there is an increasing incidence of non-steroidal anti-inflammatory drugs (NSAID), non-Helicobacter pylori (Hp) bleeding peptic ulcers. There is no datum on the natural course of these patients and this is our aim to have this observational study.

Eligibility criteria: Inclusion Criteria:

* Patient has non-NSAID (non-steroidal anti-inflammatory drugs), non-Helicobacter pylori bleeding peptic ulcer
* Age \> 18 years old
* Informed consent

Exclusion Criteria:

* Concommitant use of high dose steroid or warfarin
* New start on non-steroidal anti-inflammatory drugs or aspirin or COX2 inhibitors
* Renal failure (serum creatinine \> 200umol/l)
* Previous gastric surgery
* Oesophagitis, esophageal varices
* Terminal illness or malignancy

Primary outcomes:
measure: Recurrent ulcer bleeding
timeFrame: During the observation period
Secondary outcomes:
measure: All-cause mortality
timeFrame: During the observation period
Other outcomes:
Locations:
city: Shatin
country: China
facility: Endoscopy Center, Prince of Wales Hospital
state: Hong Kong
Study officials:
affiliation: Chinese University of Hong Kong
name: Francis K Chan, MD
role: PRINCIPAL_INVESTIGATOR
References: