Clinical trial NCT05672784: Genicular Nerve Block Versus Its Combination With Infiltration Between Popliteal Artery and Capsule of Posterior Knee
Official title: Genicular Nerve Block Versus Its Combination With Infiltration Between Popliteal Artery and Capsule of Posterior Knee for Enhanced Recovery After Total Knee Arthroplasty
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Postoperative Pain
Keywords: genicular ,IPACK, total knee
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
First posted: 2023-01-05
Enrollment: 63
Sex: ALL
Minimum age (years): 21
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Comparison of the analgesic and physical recovery effect of genicular nerve block (GNB) alone and (GNB + infiltration between popliteal artery and posterior capsule of the knee (IPACK) in patients undergoing total knee replacement

Detailed description: Comparison of preemptive analgesia of (GNB) with (GNB+ IPACK) on postoperative pain control and recovery of knee physical activity in patient undergoing total knee replacement.

Eligibility criteria: Inclusion criteria:

* Adult patients aged between 21 to 60 years
* undergoing primary unilateral elective total knee arthroplasty under spinal anesthesia
* Having informed consents
* patients with physical status ASA I \& II
* both genders
* body mass index less than 40 kg/m2.

Exclusion criteria

* patients with Peripheral vascular disease
* patients with history of allergy to local anesthesia or opioid analgesia,
* those on anti-platelet, anticoagulant or B blocker drugs
* Patients with acute decompensated heart failure
* Patients with hypertension
* Patients with heart block
* Patients with coronary disease
* Patients with bronchial asthma
* Patients with bleeding disorders
* Patients with compromised renal or hepatic function
* pregnant female.

Primary outcomes:
measure: 2 hours visual analogue scale
timeFrame: at 2 hour postoperative.
measure: 4 hours visual analogue score
timeFrame: at 4 hours postoperative
measure: 6 hours visual analogue score
timeFrame: at 6 hours postoperative
measure: 8 hours visual analogue score
timeFrame: at 8 hours postopertaive
measure: 12 hours visual analogue score
timeFrame: at 12 hours postoperative
measure: 18 hours visual analogue score
timeFrame: at 18 hours postoperative
measure: 24 hours visual analogue score
timeFrame: at 24 hours postoperative
Secondary outcomes:
measure: • Time of performance of block
timeFrame: from putting of U.S probe till the end of block procedure
measure: • Total morphine consumption
timeFrame: at 24 hours post-operatively
measure: •incidence of Anticipated side effect
timeFrame: at 24,48 hours postoperative
measure: degree of maximum active flexion and extension of the knee
timeFrame: at 24 hours post operative
measure: walk test
timeFrame: at 24 hours post operative
measure: holding quadriceps muscle
timeFrame: at 24 hours post operative
measure: time up and go (TUG)
timeFrame: at 24 hours post operative
Other outcomes:
Locations:
city: Zagazig
country: Egypt
facility: Heba M Fathi
Study officials:
References: