Clinical trial NCT04070703: Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment
Official title: Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Mild Cognitive Impairment
Keywords: Cognitive function
mild cognitive impairment
Tai Ji Quan
Lead sponsor: Oregon Research Institute
Sponsor class: OTHER
First posted: 2019-08-28
Enrollment: 332
Sex: ALL
Minimum age (years): 65
Maximum age (years): 95
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: To determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health in improving global cognitive function and dual-task ability in older adults with mild cognitive impairment.

Detailed description: The primary aim of the study is to determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health, relative to a standard Tai Ji Quan intervention and an exercise stretching control, in improving global cognitive function and dual-task ability among community-dwelling older adults with amnestic mild cognitive impairment.

Eligibility criteria: Inclusion Criteria:

* complaint of memory loss
* clinical dementia rating (CDR) scale score ≤0.5
* having normal general cognitive function screened, with MMSE ≥24
* capable of exercising safely, as determined by a healthcare provider
* willingness to be randomly assigned to an intervention condition and complete the 24-week intervention and 6-month follow-up

Exclusion Criteria:

* having medical conditions likely to compromise survival, such as metastatic cancer, or render a participant unable to engage in physical activity, such as severe cardiac failure
* participating in any type of Tai Ji Quan or daily and/or structured vigorous physical activity (i.e., brisk walking for exercise 30 minutes or longer at a time, or engaging in muscle-strengthening activities, e.g., weight lifting on 3 or more days per week 3 months prior to the study)

Primary outcomes:
measure: Montreal Cognitive Assessment
timeFrame: baseline, 6 months
measure: gait under a dual-task condition - walking with no cognitive task, walking with a concurrent cognitive task
timeFrame: baseline, 6 months
Secondary outcomes:
measure: Clinical Dementia Rating
timeFrame: baseline, 6 months
measure: Paper-and-pencil domain-specific cognitive battery tests
timeFrame: baseline, 6 months
measure: Computerized cognitive battery tests
timeFrame: baseline, 6 months
measure: Physical performance - Functional Reach; Short Physical Performance Battery
timeFrame: baseline, 6 months
Other outcomes:
measure: Sleep quality - Pittsburgh Sleep Quality Index (PSQI)
timeFrame: baseline, 6 months
measure: Depression - Geriatric Depression Scale (GDS)
timeFrame: baseline, 6 months
measure: Activity and movement confidence scales
timeFrame: baseline, 6 months
measure: Quality of life - EuroQol.
timeFrame: baseline, 6 months
measure: Physical activity - International Physical Activity Questionnaire (IPAQ)
timeFrame: baseline.
Locations:
city: Eugene
country: United States
facility: Oregon Research Institute
state: Oregon
Study officials:
affiliation: Oregon Research Institute
name: Fuzhong Li, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Li F, Harmer P, Fitzgerald K, Winters-Stone K. A cognitively enhanced online Tai Ji Quan training intervention for community-dwelling older adults with mild cognitive impairment: A feasibility trial. BMC Geriatr. 2022 Jan 25;22(1):76. doi: 10.1186/s12877-021-02747-0.