louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05023512: Understanding Public Attitudes Towards the COVID-19 Vaccination
Official title: Together Researching Understanding, Solidarity, and Trust Around COVID - TRUST Study
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Covid19
Vaccination
Lead sponsor: University of Massachusetts, Worcester
Sponsor class: OTHER
Collaborators: name: Boston University
name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2021-08-26
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: The objective of this study is to better understand public attitudes towards coronavirus disease 2019 (COVID-19) vaccination. This understanding will inform the development of community engagement strategies to be used in future interventions and studies aimed at addressing factors that impact the disproportionate burden of COVID-19 in under-served and vulnerable communities.

Detailed description: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly instigated a global pandemic. As of this writing, there are more than 33 million documented cases of infection in the United States (US). Furthermore, in the US, COVID-19 has disrupted the economy, overwhelmed the healthcare system, led to widespread school cancellations, and caused more than 595,000 deaths since March 2020.

The availability of three highly effective vaccines against COVID-19 within a year of the start of the pandemic is an extraordinary achievement and cause for great optimism. However, a significant proportion of adults in the U.S. have not accepted vaccination against COVID-19. Efforts are needed to identify effective messages and communication strategies to overcome COVID-19 vaccine hesitancy.

To address this need, the investigators plan to conduct two rapid surveys among Massachusetts residents, to assess attitudes towards COVID-19 vaccination.

Eligibility criteria: Inclusion Criteria:

* Massachusetts resident
* Adult (age 18 and over)
* English or Spanish speaking

Exclusion Criteria:

• Non-English or Spanish speaking

Primary outcomes:
measure: Intent to be vaccinated against Covid-19 among unvaccinated participants
timeFrame: Through survey completion, an average of 12 minutes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of Massachusetts, Worcester
name: Kimberly Fisher, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06718712: Resistance Exercise Volume and Hypertrophic Response Variability in Elderly
Official title: Effects of Resistance Exercise Volume on the Variability of the Hypertrophic Response in Elderly
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging
Muscle Hypertrophy
Keywords: aging
muscle mass
muscle strength
resistance exercise
sets
Lead sponsor: University of Sao Paulo General Hospital
Sponsor class: OTHER
Collaborators: name: University of Sao Paulo
First posted: 2024-12-05
Enrollment: 102
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Lower body unilateral design
Primary purpose: OTHER

Brief summary: The study aimed to investigate the effects of resistance training volume manipulation on whole muscle hypertrophy among non-responders and responders to a low resistance training dose (single-set).

Detailed description: The magnitude of muscle hypertrophy in response to resistance training (RT) is highly variable between individuals (response heterogeneity). Manipulations in RT variables may modulate RT-related response heterogeneity; yet, this remains to be determined.

Eligibility criteria: Inclusion Criteria:

* 60 years and older
* not engaged in regular resistance and/or aerobic training for at least six months before the intervention

Exclusion Criteria:

* diagnosed type I diabetes mellitus
* arrhythmia
* noncontrolled hypertension
* any major orthopedic musculoskeletal condition
* use of any dietary supplement or drug with potential anabolic effects

Primary outcomes:
measure: Quadriceps muscle cross-sectional area
timeFrame: 10 weeks
Secondary outcomes:
measure: Maximum dynamic strength
timeFrame: 10 weeks
Other outcomes:
measure: Dietary assessment
timeFrame: Before intervention
measure: Mass spectrometry
timeFrame: 10 weeks
measure: Skeletal muscle RNA-sequencing
timeFrame: 10 weeks
measure: Muscle protein measures
timeFrame: 10 weeks
measure: Muscle protein measures
timeFrame: 10 weeks
measure: Muscle protein measures
timeFrame: 10 weeks
measure: Muscle protein measures
timeFrame: 10 weeks
Locations:
city: Sao Paulo
country: Brazil
facility: University of Sao Paulo
state: SP
Study officials:
References:
Clinical trial NCT01621412: HIV Disclosure and Medication Adherence, a Pilot Study
Official title: HIV Disclosure and Medication Adherence, a Pilot Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: HIV Infection
Keywords: Medication Adherence
HIV infection
Disclosure
Lead sponsor: Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Sponsor class: OTHER
Collaborators: name: Centre Hospitalier Universitaire Vaudois
name: Swiss HIV Cohort Study
First posted: 2012-06-18
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients enrolled in the adherence-enhancing program at ther pharmacy of Department of Ambulatory Care and Community Medicine in Lausanne

Brief summary: The investigators believe that disclosure of HIV status could influence medication adherence. If disclosure leads to social support, adherence could be improved. This study purpose is to assess correlation between disclosure and medication adherence, and to describe people whose HIV status has been disclosed to.

Detailed description: Pharmacists administer a questionnaire to each consecutive subject taking part in the adherence-enhancing program at the pharmacy of the Department of Ambulatory Care And Community Medicine in Lausanne. This questionnaire assesses disclosure, response to disclosure, and living situation.

Adherence is measured by electronic monitoring and pill count.

Eligibility criteria: Inclusion Criteria:

* HIV Infection
* Enrolled in the adherence-enhancing program

Exclusion Criteria:

* Inclusion visit
* Not french or english speaker

Primary outcomes:
measure: Patient Adherence
timeFrame: 30 days before survey
Secondary outcomes:
measure: Patient Adherence
timeFrame: 90 days before survey
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: Policlinique Médicale Universitaire
state: Vaud
Study officials:
affiliation: Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
name: Marie-Paule Schneider, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
name: Aurélie Gertsch, PhD-Student
role: PRINCIPAL_INVESTIGATOR
affiliation: Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
name: Olivier Bugnon, Professor
role: STUDY_CHAIR
affiliation: Centre Hospitalier Universitaire Vaudois
name: Matthias Cavassini, MD
role: STUDY_CHAIR
References:
Clinical trial NCT00104312: Osteoarthritis: Weakness From Inflammation
Official title: Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoarthritis
Keywords: Knee Osteoarthritis
Muscle
Cytokine
Mobility
Function
Lead sponsor: National Institute on Aging (NIA)
Sponsor class: NIH
First posted: 2005-02-25
Enrollment: 88
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community - Men and women

Brief summary: The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.

Detailed description: Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.

This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.

Participation in this study is entirely voluntary.

Eligibility criteria: Inclusion Criteria:

* 50 years of age or older
* Normal body weight (a Body Mass Index (BMI) of 30 or less)
* Osteoarthritis of the knee (prior to knee surgery)
* Planning to have knee surgery at a MedStar Hospital

Exclusion Criteria:

* History of a stroke
* History of muscle weakness or paralysis
* History of Rheumatoid Arthritis or
* Inflammatory Joint Disease
* History of a Bleeding Disorder
* History of Gout
* Diabetes for which you take insulin
* Polymyalgia rheumatica (total body muscle aching/stiffness)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Harbor Hospital
state: Maryland
Study officials:
affiliation: NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics
name: Shari Ling, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Cooper C, Snow S, McAlindon TE, Kellingray S, Stuart B, Coggon D, Dieppe PA. Risk factors for the incidence and progression of radiographic knee osteoarthritis. Arthritis Rheum. 2000 May;43(5):995-1000. doi: 10.1002/1529-0131(200005)43:53.0.CO;2-1.
citation: Slemenda C, Heilman DK, Brandt KD, Katz BP, Mazzuca SA, Braunstein EM, Byrd D. Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women? Arthritis Rheum. 1998 Nov;41(11):1951-9. doi: 10.1002/1529-0131(199811)41:113.0.CO;2-9.
citation: Conwit RA, Stashuk D, Tracy B, McHugh M, Brown WF, Metter EJ. The relationship of motor unit size, firing rate and force. Clin Neurophysiol. 1999 Jul;110(7):1270-5. doi: 10.1016/s1388-2457(99)00054-1.
Clinical trial NCT04149912: Professional Quality of Life in German Psychologists
Official title: Professional Quality of Life in German Psychologists Working With Patients With Mental Disorders
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mental Disorder
Burnout, Caregiver
Burnout, Professional
Keywords: Professional quality of life
Compassion satisfaction
Burnout
Psychologists
Mental disorders
Mental health
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2019-11-04
Enrollment: 454
Sex: ALL
Minimum age (years): 18
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Clinical psychologists that currently work with patients with mental disorders in Germany.

Brief summary: The purpose of this study is to assess professional quality of life in German psychologists working with patients with mental disorders.

Detailed description: The purpose of this study is to assess professional quality of life, which includes compassion satisfaction, burnout and secondary traumatization in clinical psychologists, working with patients with mental disorders, in Germany.

Eligibility criteria: Inclusion Criteria:

* Clinical psychologist
* Currently working with patients with mental disorders
* At least 18 years old
* Sufficient German skills for answering the questionnaire

Exclusion Criteria:

None

Primary outcomes:
measure: Compassion Satisfaction
timeFrame: 1 day
measure: Burnout
timeFrame: 1 day
measure: Secondary Traumatization
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Charité Universitätsmedizin Berlin - Department for Psychiatry and Psychotherapy - Charité Campus Mitte
Study officials:
affiliation: Charité Universitätsmedizin Berlin- Charité Campus Mitte - Department for Psychiatry and Psychotherapy
name: Moritz B Petzold, Dipl.-Psych.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01228812: Physical Activity Behavior of Rheumatoid Arthritis Patients and Healthy Controls
Official title: An Observational Study of Physical Activity Behavior of Swiss Rheumatoid Arthritis Patients and Healthy Matched Controls
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rheumatoid Arthritis
Keywords: Rheumatoid arthritis, physical activity
Lead sponsor: University of Lausanne
Sponsor class: OTHER
First posted: 2010-10-27
Enrollment: 505
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients from the RA patients group will be selected in the Rheumatology Department of the Centre Hospitalier universitaire Vaudois in Lausanne. Healthy matched controls will be randomly selected from a cohort study conducted in Lausanne.

Brief summary: The purpose of the study is to compare physical activity behaviour of rheumatoid arthritis patients with healthy matched controls.


Eligibility criteria: Inclusion Criteria (RA patients):

* Rheumatoid arthritis
* Functional classes I, II and III
* Age 40 to 80 years
* Stable disease activity
* Stable DMARDS last 3 months

Exclusion Criteria (RA patients):

* Functional classes IV
* Inflammatory flare

Primary outcomes:
measure: Physical activity
timeFrame: Up to 4 weeks
Secondary outcomes:
measure: Functional status
timeFrame: Up to 4 weeks
measure: Pain
timeFrame: Up to 4 weeks
measure: Fatigue
timeFrame: Up to 4 weeks
measure: Disease activity
timeFrame: Up to 4 weeks
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: Centre Hospitalier Universitaire Vaudois, Département de l'Appareil Locomoteur
Study officials:
affiliation: Université de Lausanne, Service de Rhumatologie, Département de l'Appareil Locomoteur, Lausanne, Suisse
name: Alexander KL So, PhD, FRCP
role: STUDY_DIRECTOR
affiliation: Université de Lausanne, Service de Rhumatologie, Département de l'Appareil Locomoteur, Lausanne, Suisse
name: Yves Henchoz, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Université de Lausanne, Service de Rhumatologie, Département de l'Appareil Locomoteur, Lausanne, Suisse
name: Jean Dudler, PD, MER
role: STUDY_CHAIR
affiliation: Etude CoLaus, Centre Hospitalier Universitaire Vaudois, Lausanne
name: François Bastardot, MD
role: STUDY_CHAIR
affiliation: Etude CoLaus, Centre Hospitalier Universitaire Vaudois, Lausanne
name: Peter Vollenweider, MD
role: STUDY_CHAIR
affiliation: Unité d'Epidémiologie Populationnelle, Département de médecine communautaire et de premier recours, Hôpitaux Universitaires de Genève
name: Idris Guessous, MD
role: STUDY_CHAIR
References:
citation: Henchoz Y, Bastardot F, Guessous I, Theler JM, Dudler J, Vollenweider P, So A. Physical activity and energy expenditure in rheumatoid arthritis patients and matched controls. Rheumatology (Oxford). 2012 Aug;51(8):1500-7. doi: 10.1093/rheumatology/kes067. Epub 2012 Apr 25.
Clinical trial NCT03501212: Effect of Topical Anesthesia on Patient's Pain Discomfort and Radial Artery Spasm in Transradial Catheterization
Official title: Effect of Topical Anesthesia on Patient's Pain Discomfort and Radial Artery Spasm in Transradial Catheterization
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Radial Artery Spasm
Lead sponsor: Phramongkutklao College of Medicine and Hospital
Sponsor class: OTHER
First posted: 2018-04-18
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluate topical anaesthesia application for 30 minutes before tranradial catheterization during cardiac catheterization can reduce pain and decrease radial artery spasm

Detailed description: The incidence of Radial artery spasm (RAS) has varied from 5-30% RAS refers to friction between the artery and wires or guide catheters accompanied by a subjective feeling of pain.

EMLA anesthetic ointment (AO-Astra Zeneca) is an emulsion of lidocaine 2.5% and prilocaine 2.5% in a ratio of 1:1 by weight Previous study showed that EMLA cream can increase the success rate of femoral cannulation in children.

Eligibility criteria: Inclusion Criteria:

* Patients age \>18 years.
* Patients who was schedule to performed coronary angiogram

Exclusion Criteria:

Previous ipsilateral transradial approach Raynaud's syndrome ESRD History of sensitivity to local anesthetics Non-palpable redial pulse Abnormal Barbeau's test Local site infection Patient's refusal

Primary outcomes:
measure: Radial pain assessed during artery puncture
timeFrame: 30 min
Secondary outcomes:
measure: Radial pain assessed 30 min after sheath removal
timeFrame: 4 hr post procedure
measure: Number of puncture attempts
timeFrame: imediate post procedure
measure: Occurrence of radial artery spasm
timeFrame: during and post procedure up to 1 years
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Department of Internal Medicine
Study officials:
References:
Clinical trial NCT00192712: Irinotecan, Gemcitabine and Radiation Therapy for Pancreatic Cancer
Official title: Phase II Study of Irinotecan and Gemcitabine (IrinoGem) Combined With 3-D Conformal Radiation Therapy for Locally Advanced Pancreatic Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Pancreatic Cancer
Keywords: carcinoma
pancreas
chemotherapy
radiotherapy
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2005-09-19
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The study hypothesis is that chemoradiation based on 2 drugs will improve local control and long-term survival in patients with locally advanced pancreatic cancer. That is why gemcitabine and irinotecan are combined in an induction phase of 2 months and then this IrinoGem combination is given for 3 more cycles, in reduced doses,concurently with irradiation.


Eligibility criteria: Inclusion Criteria:

* locally advanced pancreatic cancer
* performance status 0-2
* normal blood count and chemistry
* no previous chemotherapy or radiotherapy

Exclusion Criteria:

* serious concurrent systemic disease

Primary outcomes:
measure: time to treatment failure
Secondary outcomes:
measure: response rate, survival, toxicity
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Department of Oncology, Rambam Medical Center
Study officials:
name: Ron Epelbaum, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00694512: Ghrelin Regulation and Structure: Effect of Diet Composition on Ghrelin
Official title: Ghrelin Regulation and Structure: Effect of Diet Composition on Ghrelin
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Lead sponsor: Oregon Health and Science University
Sponsor class: OTHER
First posted: 2008-06-10
Enrollment: 51
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to learn more about how diet affects the hormone ghrelin. Ghrelin is made in the stomach and causes appetite to increase. Learning about ghrelin will help the investigators understand more about obesity.

Detailed description: Control subjects will be provided 3 different diets for 2 weeks each. At the end of each diet period participants will be admitted to OHSU Clinical Translation Research Center (CTRC) for blood sampling every 30 minutes for 13.5 hours, to measure levels of hormones. Participants will also have a DXA scan to measure body composition.

PWS subjects will have one admission after eating a standardized diet prepared by caregivers for 2 weeks.

Eligibility criteria: Inclusion Criteria:

* Age 18 or older.
* Weight stable for at least 3 months.
* At lifetime maximal body weight.

Exclusion Criteria:

* Actively losing weight by diet or exercise.
* Smokers.
* Alcohol consumption \> 2 drinks per day.
* Exercise \> 30 minutes 3 times a week.
* Prescription drug use (except birth control pills, vitamins, or minerals).
* Type 2 diabetes.
* Heart disease, cancer, malabsorptive states, or chronic infections that would affect body weight.
* Weight \> 300 lbs (exceeds the weight limit of the DEXA machine).
* Hemoglobin \< 12.0 g/dL for women, \< 13.5 g/dL for men

Primary outcomes:
measure: The primary outcomes for aim 1 are the suppression of total and acylated ghrelin from peak fasting (highest value) level to nadir (lowest level) during the 4 hours after each meal, comparing the obese to the lean subjects.
timeFrame: every 8 weeks
Secondary outcomes:
measure: Area-under-the-curve measurements during the 12 ½ hours of testing for ghrelin and other nutrient and gut-peptides, including glucose, insulin, PYY3-36, and active GLP-1.
timeFrame: Every 8 weeks
Other outcomes:
Locations:
city: Portland
country: United States
facility: Oregon Health & Science University
state: Oregon
Study officials:
affiliation: Oregon Health and Science University
name: Jonathan Q. Purnell, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03789812: Oral Hygiene in Patients With Orthodontic Fixed Appliances
Official title: Efficacy of Different Methods of Teeth Cleaning on Oral Hygiene in Patients With Orthodontic Fixed Appliances
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Oral Hygiene
Lead sponsor: Riyadh Colleges of Dentistry and Pharmacy
Sponsor class: OTHER
First posted: 2018-12-31
Enrollment: 100
Sex: ALL
Minimum age (years): 14
Maximum age (years): 50
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The study aims to compare the efficacy of the use of different methods of teeth cleaning on the oral hygiene in patients with orthodontic fixed appliance

Detailed description: Subjects were randomized into four groups, the first group will receive manual tooth brush with super floss, the second group will receive electric tooth brush with super floss, the third group will receive manual tooth brush with water dental flosser and the fourth group will receive electric tooth brush with water flosser.

Eligibility criteria: Inclusion Criteria:

1. participants with fixed orthodontic appliance.
2. participants age 14 years and above and didn't have mental of physical disabilities.
3. participants willing to comply with given oral hygiene instructions.

Exclusion Criteria:

1. patients with mental retardation.
2. patients with systematic diseases.

Primary outcomes:
measure: Change in plaque index
timeFrame: baseline, after 4 weeks and after 8 weeks
measure: Change in gingival index
timeFrame: baseline, after 4 weeks and after 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Riyadh
country: Saudi Arabia
facility: Omar AlKadhi
Study officials:
References: