Clinical trial NCT05613790: Effect of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Attentional Control: an fMRI Study on Healthy Participants
Official title: Effect of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Attentional Control: an fMRI Study on Healthy Participants
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy Volunteers
Keywords: High-Definition Transcranial Direct Current Stimulation
HD-tDCS
functional Magnetic Resonance Imaging
Attentional control
Attention Network Test
Lead sponsor: University of Tehran
Sponsor class: OTHER
First posted: 2022-11-14
Enrollment: 24
Sex: ALL
Minimum age (years): 20
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants are allocated to one of two conditions: Active or Sham.
Primary purpose: TREATMENT

Brief summary: In a randomized, triple-blind, sham-controlled clinical trial, we will assess the effect of a single session frontal cortex High-Definition transcranial Direct Current Stimulation (HD-tDCS) on brain activity and functional connectivity underlying the behavioral change in attentional control in healthy participants. Participants will be recruited after meeting the inclusion criteria and will be randomly assigned to active or sham stimulation groups. All participants will undergo resting-state functional Magnetic Resonance Imaging (rsfMRI) scan and perform an Attention Network Test (ANT) in a functional Magnetic Resonance Imaging (fMRI) scanner before and after receiving a single session of active or sham HD-tDCS.


Eligibility criteria: Inclusion Criteria:

* Right-handed healthy adults
* Age range 20-39 years
* Normal or corrected-to-normal vision
* Willing and capable of following study protocol requirements given in the informed consent

Exclusion Criteria:

* Psychiatric conditions (e.g., depression and generalized anxiety disorder, etc.)
* Medical illness or neurological disorder (e.g., cardiovascular illness, anemia, respiratory illness, neurological illness, seizure, etc.)
* Current abuse of drugs or alcohol
* Any conditions that prevent undergoing an fMRI scan or tDCS stimulation according to the fMRI and tDCS safety checklists

Primary outcomes:
measure: Change in Attention Network Test (ANT) performance before and after the intervention (active versus sham HD-tDCS)
timeFrame: Immediate before and immediate after intervention
measure: Change in resting state functional connectivity before and after the intervention (active versus sham HD-tDCS)
timeFrame: Immediate before and immediate after intervention
measure: Change in task-based functional connectivity during Attention Network Test (ANT) before and after the intervention (active versus sham HD-tDCS)
timeFrame: Immediate before and immediate after intervention
measure: Change in the blood-oxygen-level-dependent (BOLD) signal during Attention Network Test (ANT) before and after the intervention (active versus sham HD-tDCS)
timeFrame: Immediate before and immediate after intervention
Secondary outcomes:
measure: Side effect checklist for transcranial Direct Current Stimulation (Reported as Yes or No)
timeFrame: One day after simulation session
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Faculty of Psychology
Study officials:
References: