louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01121250: Spouse READI (Resilience Education And Deployment Information) Post Deployment Telephone Support Groups
Official title: Spouse READI (Resilience Education And Deployment Information) Post Deployment Telephone Support Groups
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Spouses
Military Personnel
Coping Skills
Keywords: Combat disorders
Spouses
Support
Military personnel
Lead sponsor: Memphis VA Medical Center
Sponsor class: FED
Collaborators: name: U.S. Army Medical Research and Development Command
First posted: 2010-05-12
Enrollment: 228
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This 12-month study is for spouses or significant others of service members who have returned from Afghanistan or Iraq. This study will determine if participating in a telephone discussion group, offering education, skills building, and support, will help increase post-deployment adjustment. There will be 225 spouses recruited for this study.


Eligibility criteria: Inclusion Criteria:

1. have a spouse who participated in a deployment to Iraq and Afghanistan and is at least 1 month post-deployment
2. if not married, must have lived as married for at least one year
3. must be committed to the relationship
4. have a telephone.

Exclusion Criteria:

1. known deployment of spouse in the next six months
2. auditory impairment that would make telephone use difficult.

Primary outcomes:
measure: Spouse Self-report of Anxiety
timeFrame: Baseline, 6 months, and 12 months
measure: Spouse Self-report of Depression
timeFrame: Baseline, 6 months, and 12 months
measure: Spouse Self-report of Resilience
timeFrame: Baseline, 6 months, and 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Memphis
country: United States
facility: Memphis VA Medical Center
state: Tennessee
Study officials:
affiliation: Memphis VA Medical Center and University of Tennessee Health Science Center
name: Linda O Nichols, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Tennessee Health Science Center and VA Medical Center Memphis
name: Jennifer L Martindale-Adams, Ed.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Nichols, L.O., Martindale-Adams, J., Zuber, J., Graney, M., Burns, R., & Clark, C. Support for Spouses of Post Deployment Service Members. Military Behavioral Health, Published online: 30 Jan 2015. DOI:10.1080/21635781.2015.1009210
citation: Nichols L.O., Martindale-Adams, J., Zuber, J., & Graney, M. Service Member Need and Supportive Services Use of Military/Veteran Spouses. Military Behavioral Health, Published online: 09 Feb 2015, DOI:10.1080/21635781.2014.995251
Clinical trial NCT06665750: Neuromuscular Training in Recreational Tennis Players
Official title: Effect of Neuromuscular Training on Upper Extremity Performance in Recreational Tennis Players
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sport Injuries
Lead sponsor: Muğla Sıtkı Koçman University
Sponsor class: OTHER
First posted: 2024-10-30
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to investigate the effect of upper extremity neuromuscular exercise training on throwing performance, upper extremity strength, and endurance in recreational tennis players. In this context, 24 recreational tennis players will be included in the study. Participants will be divided into two equal groups using a simple randomization method. The study group (n=12) will receive progressive upper extremity neuromuscular exercise training twice a week for six weeks before each tennis training session, while the control group will perform only routine warm-up exercises. Both groups will be evaluated twice, once at the beginning of the study and again at the end of the six-week intervention. Throwing performance will be assessed using the Functional Throwing Performance Index (FTPI) and the International Tennis Number Test (ITN). Upper extremity endurance will be evaluated through the Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) and Scapula Muscle Endurance Test (SME), while upper extremity strength will be measured using the Health Ball Throw Test (HBT) and the Y Balance Upper Extremity Test (YBUET). Statistical analysis will be conducted using SPSS 24.0 software.


Eligibility criteria: Inclusion Criteria:

1. Being between the ages of 18-50
2. Being a recreational tennis player
3. Playing tennis regularly for at least 1 year
4. Playing tennis regularly at least twice a week for the last 6 months

Exclusion Criteria:

1. Playing another sport along with tennis
2. Being a professional tennis player
3. Having a history of any injury and/or surgery affecting the upper extremity

Primary outcomes:
measure: Functional Throwing Performance Index (FTPI)
timeFrame: baseline and after six weeks
Secondary outcomes:
measure: International Tennis Number Test (ITN)
timeFrame: baseline and after six weeks
measure: Closed Kinetic Chain Upper Extremity Stability Test
timeFrame: Baseline and after six weeks
measure: Scapula Muscle Endurance Test
timeFrame: Baseline and after six weeks
measure: Health Ball Throw Test
timeFrame: Baseline and after six weeks
measure: Y Balance Upper Extremity Test
timeFrame: Baseline and after six weeks
Other outcomes:
Locations:
city: Menteşe
country: Turkey
facility: Mugla Sitki Kocman University
Study officials:
References:
Clinical trial NCT00242450: Metoclopramide Use in Very Low Birth Weight Newborns
Official title: The Effect of Metoclopramide on Feeding in Very Low Birthweight Newborns : a Randomized, Double Blind, Placebo Controlled Pilot Study and a Proposal for a Multicentre Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Infant, Premature
Keywords: metoclopramide
feeding
very low birthweightnewborn
Lead sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sponsor class: OTHER
First posted: 2005-10-20
Enrollment: 30
Sex: ALL
Minimum age (years): 72
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: During the first 7 days of life very small babies will receive the drug metoclopramide or a salt solution through an intravenous line. They will also begin to receive a very small amount of breast milk or formula within the first 72 hours of life, in addition toother nourishment that is provided by an intravenous line, according to standard hospital procedure. We think that the babies who receive the medication may reach full oral feeds than babies who receive the salt solution.

Detailed description: Clinically stable, premature babies (birth weight between 500 and 1,250g) will be randomized to receive metoclopramide (0.1 mg/kg IV q8h)or an equal volume of placebo for 7 days.A transition feeding schedule will begin within the first 72 hours of life. The time to full feeds for the 2 groups will be analyzed.

Eligibility criteria: Inclusion Criteria:

* birth weight 500 to 1,250g
* clinically stable
* no contraindications to initiating minimal enteral feeding

Exclusion Criteria:

* birth weight \> 1,250g
* clinically unstable
* any major congenital anomaly
* significant GI pathology
* severe IUGR
* cholestasis

Primary outcomes:
measure: Days required to attainment of full feeds.
Secondary outcomes:
measure: Weight at full enteral feeds (g).
measure: Weight at discharge (g).
measure: Duration of TPN (days).
measure: Length of stay(days).
Other outcomes:
Locations:
city: London
country: Canada
facility: St Joseph's Hospital
state: Ontario
Study officials:
affiliation: University of Westen Ontario
name: Orlando daSilva, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kearns GL, van den Anker JN, Reed MD, Blumer JL. Pharmacokinetics of metoclopramide in neonates. J Clin Pharmacol. 1998 Feb;38(2):122-8. doi: 10.1002/j.1552-4604.1998.tb04400.x.
Clinical trial NCT05339750: Allergy Skin Patch Artificial Intelligence (AI)
Official title: Democratization of Allergy Skin Patch Testing to Increase Efficiency and Scale of the Practice
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Allergic Contact Dermatitis
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2022-04-21
Enrollment: 233
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this research is to assess human and artificial intelligence performance in grading contact dermatitis reactions in healthy volunteers.

Detailed description: Study participation involves three visits to the study site on Days 1, 3, and 5, and completion of a demographics and allergy history questionnaire. Researchers will review medical history and current medications. On Day 1 a patch will be applied with 10 allergens and a routine skin examination will be conducted and a photograph will be taken of the forearm. On day 3, subjects will return to remove the patch test and have photographs of the area taken. On day 5, the final assessment for allergic contact dermatitis will be performed and photographs of the area taken.

Key Information: The most common side effect of skin testing is slightly swollen, red, itchy bumps (wheals). These wheals may be most noticeable during the test. In some, an area of swelling, redness and itching may develop a few hours after the test and remain for a couple of days. Rarely, allergy skin tests can produce a severe, immediate allergic reaction. The patches are worn on the forearm for 48 hours. During this time, bathing and activities that cause heavy sweating should be avoided. Irritated skin at the patch site may indicate an allergy. If a positive test result is documented, a medical professional will provide education and recommend follow up with primary care provider.

Eligibility criteria: Inclusion Criteria

* Adults over the age of 18
* Willing and able to provide informed consent

Exclusion Criteria

* Under 18 years of age
* Has used topical or oral steroids two weeks prior to patch testing
* Currently taking immunosuppression agents or is immunocompromised due to medical condition
* No sunburn or rash at site of testing
* Women who are breastfeeding or pregnant.
* Treatment with ultraviolet (UV) light (including tanning) during the two weeks prior to visit.
* Subjects unable to comply with patch test study requirements including multiple return visits and activity restrictions (e.g., protecting patch test area from excess moisture due to showering)

Primary outcomes:
measure: AI algorithms predictions of reactions
timeFrame: 6 months
Secondary outcomes:
measure: Fitzpatrick skin type assessment
timeFrame: 10 months
Other outcomes:
Locations:
city: Jacksonville
country: United States
facility: Mayo Clinic Florida
state: Florida
Study officials:
affiliation: Mayo Clinic
name: Matthew Hall, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02869750: The Relationship Between Adipokines, Obesity and Insulin Resistance in Women With Polycystic Ovarian Syndrome
Official title: Evaluation of Adipokines ( Ghrelin, Resistin and Adiponectin), in Egyptian Women With Polycystic Ovary Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Polycystic Ovarian Syndrome
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2016-08-17
Enrollment: 300
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Females with PCOS in child bearing age who presented at reproductive and endocrinology clinics at Ain Shams University Maternity Hospital

Brief summary: To evaluate possible clinical effects of adipokines , ( ghrelin, resistin and adiponectin), in obese and non-obese patients with polycystic ovary syndrome (PCOS).

Detailed description: Seventy selected PCOS patients will be recruited for this study, and will be divided into two groups based on their body mass index (BMI): 35 obese (BMI≥ 25 kg/m2, group A), 35 non-obese (BMI\<25 kg/m2, group B). In addition, 35 healthy non-obese women (BMI\<25 kg/m2) will bw enrolled as the control (group C). Serum levels of FSH (follicle stimulating hormone), LH (luteinizing hormone), T(testosterone), glucose, insulin, adiponectin, resistin and resistin will bw detected, and compared the differences of them among three groups

Eligibility criteria: Inclusion Criteria:

* Females with PCOS in child bearing age who presented at reproductive and endocrinology clinics at Ain Shams University Maternity Hospital

Exclusion Criteria:

* Known androgen secreting tumor.
* PCO on ovarian stimulation medications
* PCO with any other medical illness.

Primary outcomes:
measure: serum ghrelin level
timeFrame: 24 hours
measure: serum resistin level
timeFrame: 24 hours
measure: serum adiponectin level
timeFrame: 24 hours
Secondary outcomes:
measure: Glucose/Insulin ratio
timeFrame: 24 hours
measure: serum testosterone level
timeFrame: 24 hours after labor
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ahmed Kotb
state: Al Qahirah
Study officials:
References:
Clinical trial NCT03404050: Community Based Music and Dance Movement Therapy Group for Older Adults With Dementia
Official title: A Community Based Music and Dance Movement Therapy Group for Older Adults With Dementia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dementia
Lead sponsor: Edge Hill University
Sponsor class: OTHER
First posted: 2018-01-19
Enrollment: 7
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Assessments taken at three different time periods: week zero, week five and week eleven.
Primary purpose: TREATMENT

Brief summary: This study explores the value of a particular community based music and dance movement therapy group for older adults with dementia?

To answer this question, the investigators intend to address the following two sub-questions:

1. How does participants' use of music and movement change over time?
2. Did a music and dance movement therapy group improve participants' depressive symptoms?

Detailed description: A systematic review identified a need to explore the value of an arts therapies group for older adults with dementia living in the community with early to moderate stage dementia. This client population commonly experience depression, social withdrawal and cognitive difficulties and literature suggests a music and dance movement therapy group could potentially make a contribution to both reducing symptoms and improving communication and wellbeing. However, there is still lack of clarity on clinically meaningful outcome measures, detail regarding the therapeutic process and questions remain regarding the trustworthiness of qualitative observations. This mixed method feasibility study aims to test whether the interventions translate to a community setting, provide richer insight into the meaningful aspect of the therapeutic process and provide some preliminary quantitative findings.

Eligibility criteria: Inclusion Criteria:

* Over 65 years old
* Living in the community
* Diagnosis of dementia
* Adequate functional hearing/vision
* Sufficient knowledge of English to understand participant information sheet

Exclusion Criteria:

* Participants excluded if they suffered from any physical or psychological conditions that make it difficult to access a group setting independently.

Primary outcomes:
measure: Cornell Scale for Depression in Dementia
timeFrame: 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Ormskirk
country: United Kingdom
facility: Edge Hill University
state: Lancs
Study officials:
affiliation: Edge Hill University
name: Vicky Karkou
role: STUDY_DIRECTOR
References:
Clinical trial NCT03179150: Clinical Validation of the M5L Lung CAD
Official title: Clinical Validation of a CAD System for the Automated Identification of Pulmonary Metastases in Oncological Patients - CADM5L
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Cancer Metastatic
Keywords: computer-aided diagnosis
Web
Cloud computing
lung cancer
Lead sponsor: Candiolo Cancer Institute - IRCCS
Sponsor class: OTHER
First posted: 2017-06-07
Enrollment: 237
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Between September 2015 and March 2016, 237 consecutive patients (123 men, 52%) with an average age of 62 (range 21-90 years), were enrolled in this retrospective observational single centre study. Patients enrolled into the study performed CT either for staging, restaging or follow-up of extrathoracic malignancies

Brief summary: To compare the diagnostic performance and time efficiency of Computer-Aided Detection (CAD) assisted reading for the identification of pulmonary nodules in chest Computed Tomography (CT) from oncological patients with that of unassisted reading.

Detailed description: The main aim of this study is to compare the diagnostic performance of CAD assisted interpretation with that of unassisted reading in the detection of lung metastases in consecutive patients staged for extrathoracic malignancies. This study also aims at validating a new Web/Cloud based workflow for the use of CAD systems in clinical practice, not requiring installation of additional software or hardware and potentially representing a cost-effective CAD solution for clinical facilities.

Eligibility criteria: Inclusion Criteria:

* Diagnosed extra-thoracic neoplasm

Exclusion Criteria:

* More than 10 nodules
* Severe pulmonary fibrosis
* Diffuse bronchiectasis
* Extensive inflammatory consolidation
* Massive pleural effusion
* Pregnancy

Primary outcomes:
measure: Per-patient detection sensitivity unassisted vs CAD assisted reading
timeFrame: 1 month after collection of data
measure: Per-lesion detection sensitivity unassisted vs CAD assisted reading
timeFrame: 1 month after collection of data
Secondary outcomes:
measure: Comparison of reading time between unassisted vs CAD assisted reading
timeFrame: 1 month after collection of data
Other outcomes:
Locations:
city: Candiolo
country: Italy
facility: IRCCS Candiolo
state: Torino
Study officials:
References:
Clinical trial NCT04657250: mHealth for Smoking Cessation in Public Housing
Official title: mHealth for Smoking Cessation in Public Housing
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Smoking Cessation
Keywords: mobile phone
mHealth
text messaging
Lead sponsor: George Washington University
Sponsor class: OTHER
First posted: 2020-12-08
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Smoking rates among public housing residents are more than twice as high as in the general population. In August 2018, the U.S. Department of Housing and Urban Development (HUD) required all public housing in the U.S. to become smoke-free. While HUD recommended that Public Housing Authorities provide smoking cessations services, at present, the D.C. Housing Authority (DCHA) does not offer any cessation services to its residents. Low-income smokers face unique challenges to smoking cessation and require sustained support for smoking cessation. Digital interventions such as text messaging programs and quitline (QL) phone counseling are scalable, evidence-based interventions for smoking cessation that can provide support over an extended timeframe at low cost.

The aim of this proposed research is to conduct a feasibility trial to assess the acceptability, levels of engagement, and preliminary efficacy of an integrated program that combines text-messaging for smoking cessation and text messages providing proactive linkage to the quitline compared to a single passive quitline text message referral among DCHA residents. The investigators hypothesize that the integrated program (combining text messages for smoking cessation and proactive quitline linkage) will yield significantly higher rates of quit attempts than passive quitline referral only.


Eligibility criteria: Inclusion Criteria:

* 18 years or older
* resident of D.C. public housing
* smoked a cigarette in the 7 days prior to screening (self-report)
* has daily access to a working cell phone with an unlimited text message plan

Exclusion Criteria:

-

Primary outcomes:
measure: Proportion of participants making a quit attempt
timeFrame: 3 months
Secondary outcomes:
measure: Proportion of participants who quit smoking
timeFrame: 3 months
measure: Number of cigarettes smoked per day
timeFrame: 3 months
Other outcomes:
Locations:
city: Washington
country: United States
facility: George Washington University
state: District of Columbia
Study officials:
References: