Clinical trial NCT06947564: AccuIMR Predicts Microvascular Obstruction and Infarct Size in STEMI Patients
Official title: Angiography-derived Index of Microcirculatory Resistance Predicts Microvascular Obstruction and Infarct Size in Patients With ST-segment-elevation Myocardial Infarction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
STEMI - ST Elevation Myocardial Infarction
Microvascular Coronary Artery Disease
Keywords: AccuIMR, CMR, infarct size
Lead sponsor: RenJi Hospital
Sponsor class: OTHER
First posted: 2025-04-27
Enrollment: 843
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: STEMI patients who underwent PCI within 12 hours of symptom onset, and coronary microvascular function was assessed using contrast-enhanced CMR after PCI.

Brief summary: In this study, we aimed to investigate the clinical significance of the angiography-based IMR calculation method (AccuIMR) and its prognostic assessment capability by evaluating the concordance or discordance between AccuIMR values and cardiac magnetic resonance (CMR) results.


Eligibility criteria: Inclusion Criteria:

* (1) STEMI patients who underwent PCI within 12 hours of symptom onset.
* (2) coronary microvascular function was assessed using contrast-enhanced CMR after PCI.

Exclusion Criteria:

* (1) Suboptimal coronary angiographic images, including inadequate contrast opacification, unsatisfactory projection view, and severe overlap or distortion of the target vessel.
* (2) Lacking two angiographic projections separated by at least 25° apart post-PCI.
* (3) Inadequate CMR image quality

Primary outcomes:
measure: CMR
timeFrame: CMR was performed at a median of 5 days post-reperfusion.
Secondary outcomes:
measure: LDL-C, mmol/L
timeFrame: Blood samples were collected after a 12-hour fast in the second day post-PCI.
measure: HbA1c, %
timeFrame: Blood samples were collected after a 12-hour fast in the second day post-PCI.
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Renji Hospital
state: Shanghai
Study officials:
affiliation: RenJi Hospital
name: Jun Pu, MD, PhD
role: STUDY_CHAIR
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