Clinical trial NCT03024164: Stroke Registration of Young Adults in China
Official title: Stroke Registration of Young Adults in China
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Ischemic Stroke
Keywords: youth; etiology; prognosis; recurrence; biomarkers
Lead sponsor: The First Hospital of Jilin University
Sponsor class: OTHER
Collaborators: name: Jiujiang No.1 People's Hospital
name: Dezhou People's Hospital
name: The Affiliated Hospital of Yanbian University
name: First Affilated Hospital of Jiamusi University
name: Xuchang Central Hospital
name: Inner Mongolia People's Hospital
name: Shaoxing People's Hospital
name: Chinese PLA General Hospital
name: General Hospital of Ningxia Medical University
name: General Hospital of Shenyang Military Region
name: Siping Central People's Hospital
name: The First Affilated Hospital of the Medical College, Shihezi University
name: Daqing Oilfieled General Hospital
name: Heilongjiang Provicial Hospital
name: The First Affiliated Hospital of Soochow University
name: Luoyang Central Hospital Affilated to Zhengzhou University
name: Wuzhou Red Cross Hospital
name: Cangzhou Central Hospital
name: Binzhou Medical University
name: Affilated Hospital of Inner Mongolia University for the Nationalities
name: Fudan University Pudong Medical Center
First posted: 2017-01-18
Enrollment: 3000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Young adult patients who had their first-ever ischemic stroke symptoms within 72 hours and visited one of the 22 participating medical centers in People's Republic of China.

Brief summary: This is a multi-center, prospective,continuous registry study. The investigators will include 3000 young adult (18-45 years old) patients with confirmed first-ever acute ischemic stroke in China. The main purpose of this study is to build the study cohort of young ischemic stroke patients in China, and to compare the prognosis and stroke recurrence of young patients with different ischemic stroke subtypes. Secondary objectives are trying to find biomarkers of stroke recurrence.

Detailed description: Approximately 10%-14% of all ischemic strokes occur in young adults ages 18 to 45 years old. Stroke etiology in this population differs by geographic region and has greater heterogeneity than in older individuals. Ascertain the definite etiologic classification in this young patients might be the key point to prevent the stroke recurrence and reduce the stroke burden. Advances in stroke diagnostic tests, particularly neuroimaging, refinement in classification schema. In this multi-center registry study conducted in China, we determine to explore the difference of prognosis and stroke recurrence of young patients with different ischemic stroke subtypes.

Eligibility criteria: Inclusion Criteria:

* Age 18 through 45 years, both genders
* First-ever acute ischemic stroke
* Onset of symptoms within 72 hours of inclusion
* Willing to participate in follow-up visits

Exclusion Criteria:

* Silent stroke
* Failure to give their informed consent

Primary outcomes:
measure: Stroke recurrence
timeFrame: 1 year
measure: Post-stroke disability
timeFrame: 3 months
Secondary outcomes:
measure: Cardiovascular death
timeFrame: 3 months, 6 months and 1 year
measure: Other cardiovascular event
timeFrame: 3 months, 6 months and 1 year
measure: Other systemic embolism
timeFrame: 3 months, 6 months and 1 year
Other outcomes:
Locations:
city: Changchun
country: China
facility: First Hospital of Jilin University
state: Jilin
Study officials:
References: