louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01685164: The Effect of Uterine Size and Posture on Intrauterine Contraception in Nulliparous Women
Official title: The Effect of Uterine Size and Posture on Intrauterine Contraception in Nulliparous Women
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intrauterine Contraception
Keywords: nulliparous
IUD
IUS
insertion
expulsion
Lead sponsor: Helsinki University Central Hospital
Sponsor class: OTHER
First posted: 2012-09-14
Enrollment: 161
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population consists of nulliparous women attending the centralized Family planning center of the City of Helsinki requesting intrauterine contraception, either the LNG-IUS or a Cu-IUD.

Brief summary: As intrauterine contraception is an increasingly popular form of contraception the objective of our study is to examine if uterine size or posture affects the insertion or use of intrauterine devices. Nulliparous women requesting either the levonorgestrel-releasing device (LNG-IUS) or a copper-IUD (NovaT) are recruited and followed for one year.

Detailed description: Prospective observational study among nulliparous women requesting intrauterine contraception.

Eligibility criteria: Inclusion Criteria:

- nulliparous women with no previous history of IUD use

Exclusion Criteria:

* malformation of uterus
* myomas
* acute gynecological infection
* malignant uterine or cervical tumor

In addition if requesting a Cu-IUD

* heavy menstruations
* iron deficiency
* bleeding disorder
* copper allergy or Wilson's disease

Primary outcomes:
measure: The effect of uterine size or posture on IUD insertion.
timeFrame: Day 1
Secondary outcomes:
measure: Satisfaction and continuation rate with intrauterine contraception.
timeFrame: 3 months
measure: Satisfaction and continuation rate with intrauterine contraception.
timeFrame: 12 months
Other outcomes:
Locations:
city: Helsinki
country: Finland
facility: Contraceptive unit of city of Helsinki
Study officials:
References:
citation: Kaislasuo J, Heikinheimo O, Lahteenmaki P, Suhonen S. Menstrual characteristics and ultrasonographic uterine cavity measurements predict bleeding and pain in nulligravid women using intrauterine contraception. Hum Reprod. 2015 Jul;30(7):1580-8. doi: 10.1093/humrep/dev102. Epub 2015 May 19.
citation: Kaislasuo J, Heikinheimo O, Lahteenmaki P, Suhonen S. Predicting painful or difficult intrauterine device insertion in nulligravid women. Obstet Gynecol. 2014 Aug;124(2 Pt 1):345-353. doi: 10.1097/AOG.0000000000000362.
Clinical trial NCT05819164: Comparison of Multiple Oxygenation Targets With Different Oximeters in Chronic Obstructive Pulmonary Disease (COPD) and Non-COPD Patients- Impact on Oxygen Flows
Official title: Comparison of Multiple Oxygenation Targets With Different Oximeters in COPD and Non-COPD Patients- Impact on Oxygen Flows
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: COPD Exacerbation
Pneumonia
Hypoxemia
Respiratory Disease
Keywords: oxygen, oximeter
Lead sponsor: Laval University
Sponsor class: OTHER
First posted: 2023-04-19
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The oximeter is an instrument for monitoring patients receiving oxygen therapy. It displays pulse oxygen saturation (SpO2), which is a reflection of arterial oxygen saturation (SaO2). An accurate SpO2 value is essential for optimal management of the O2 flow delivered to patients. Several factors can influence this measurement and the choice of ventilatory support: the type of oximeter used, skin pigmentation and the oxygenation goal.

The objective of our study is to evaluate the impact of the oxygenation goal and the oximeter used on oxygen flows in patients with COPD (or with hypercapnia, or at risk of hypercapnia) and in patients without COPD (in particular pneumonia, pulmonary fibrosis and other pathologies) Our hypothesis is that the SpO2 target and oximeter used will have an impact on oxygen flows and that these effects will be synergistic in these different populations.


Eligibility criteria: Inclusion Criteria:

* ≥ 18 years old
* On conventional oxygen therapy with SpO2 between 88 and 100% with the usual oximeter and nasal cannula.
* SpO2 \< 92% in ambient air with the usual oximeter

Exclusion Criteria:

* No availability of the SpO2 signal with the usual oximeter
* False nails or nail polish
* Severe anemia documented on the last blood count during the current hospitalization (Hb \< 80g/L)

Primary outcomes:
measure: Oxygen flow
timeFrame: assessed up to 10 minutes
Secondary outcomes:
measure: Partial oxygen weaning
timeFrame: assessed up to 10 minutes - until SpO2 target stability for 2 minutes
measure: Complete oxygen weaning
timeFrame: assessed up to 10 minutes - until SpO2 target stability for 2 minutes
measure: High oxygen flow
timeFrame: assessed up to 10 minutes - until SpO2 target stability for 2 minutes
measure: Oximeter bias comparison
timeFrame: assessed up to 10 minutes - until SpO2 target stability for 2 minutes
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06530264: Evaluation of Different Methods of Posterior Flap Management in External Dacryocystorhinostomy
Official title: Evaluation of Different Methods of Posterior Flaps Management in External Dacryocystorhinostomy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Acquired Nasolacrimal Duct Obstruction
Keywords: Posterior flap
DCR
NLDO
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2024-07-31
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SEQUENTIAL
Intervention model description: All patients included in this study will be verbally briefed about the details and the nature of the study \& will sign a written consent according to the local Ethics Committee of Minia University Faculty of Medicine. The study will be conducted in Ophthalmology department, Minia university Hospital, Egypt.
Primary purpose: TREATMENT

Brief summary: The aim of DCR is to form a new, mucosa-lined pathway between the lacrimal sac and the nasal cavity where tears can bypass a lacrimal obstruction and drain directly in the nose. The original external approach was described in 19046. In 1920s, mucosal flap anastomosis was added to the procedure as a modification7, and since then, many new modifications have been made to improve the original procedure.

Detailed description: Aim of The Study

• To compare intraoperative details and postoperative endonasal endoscopic findings and their effects on success rate of external dacryocystorhinostomy with and without anastomosis of posterior mucosal flaps.

Patients and Methods

Study Design: This will be a prospective interventional comparative clinical study. It will include two groups according to the surgical procedure:- Group A: includes 30 eyes that will be treated with external DCR with anastomosis of posterior mucosal flaps .

Group B: includes 30 eyes that will be treated with external DCR with amputation of posterior mucosal flaps .

Study Population:

Study participants will be: 60 eyes undergo external DCR . All patients included in this study will be verbally briefed about the details and the nature of the study \& will sign a written consent according to the local Ethics Committee of Minia University Faculty of Medicine. The study will be conducted in Ophthalmology department, Minia university Hospital, Egypt.

Eligibility criteria: Inclusion criteria

* Patients with chronic dacryocystits,
* primary nasolacrimal duct obstruction
* Lacrimal mucocele
* Lacrimal fistula

Exclusion Criteria:

* Recurrent cases.
* Age under 5 years.
* Associated nasal pathology.
* Sever dry eye
* Patients unfit for general anaesthesia

Primary outcomes:
measure: Management of posterior flap in external DCR
timeFrame: patient evaluated at 2 months after surgery then at 4th month then 6th month
Secondary outcomes:
Other outcomes:
Locations:
city: Minya
country: Egypt
facility: Faculty of medicine ,Minia university
Study officials:
References:
Clinical trial NCT05288764: Effect of Ketamine on BIS Values
Official title: Correlation Between Concentration at the Effector Site of Ketamine (Calculated With DOMINO Pump) and Bispectral Index Values During General Anaesthesia for Breast Surgery.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthesia Brain Monitoring
Ketamine
Lead sponsor: University of Padova
Sponsor class: OTHER
First posted: 2022-03-21
Enrollment: 14
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult Women undergoing breast surgery for breast cancer

Brief summary: Aim of this trial is to define if Concentration at the effector site (Ce) of Ketamine, calculated with DOMINO model infusion pump are correlated with Bispectral Index BIS values during general anaesthesia for breast surgery.

Detailed description: Correlation between Concentration at the effector site (Ce) of Ketamine and Bispectral Index (BIS) values during general anaesthesia for breast surgery has not been defined yet.

We want to analyze this correlation during general anaesthesia conducted using Propofol, ketamine and remifentanil. All of these drugs will be delivered with Targeted-ControlledInfusion pumps (in particular Eleveld for Propofol, Minto for Remifentanil and Domino for Ketamine).

Eligibility criteria: Inclusion Criteria:

* Undergo gneral anaesthsia with Targted Controlld Infusion of Ketamine (Domino model), Propofol (Schnider model) and Remifentanil (Minto model)

Exclusion Criteria:

* Neurological disease
* Psychiatric disease
* Benzodiazepiones absuntion
* Obesity

Primary outcomes:
measure: Correlation between Concentration at the effector site of Ketamine and BIS values
timeFrame: We will collected data about Drugs concentration and BIS values during general anaesthesia. We will collect BIS and TCI Ketamine values during all the duration of anesthesia, form the start of ketamine bolus until the emergence from anesthesia
Secondary outcomes:
Other outcomes:
Locations:
city: Treviso
country: Italy
facility: ULSS 2 Marca Trevigiana
state: Tv
Study officials:
References:
Clinical trial NCT03550664: Prediction of the Recovery of Neuromuscular Transmission After Curarization
Official title: Prediction of the Recovery of Neuromuscular Transmission After Curarization, Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neuromuscular Blockade
Lead sponsor: Brugmann University Hospital
Sponsor class: OTHER
First posted: 2018-06-08
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The vast majority of patients receive neuromuscular blockers during surgical procedures, either as a single injection to facilitate intubation or as repeated injections to induce muscle relaxation necessary for surgery. The action of neuromuscular blockers is monitored by measuring the contraction force of the adductor of the thumb after stimulation of the ulnar nerve.Different types of stimulation, such as train-of-four (TOF), post- Tetanus count (PTC), double-burst stimulation (DBS) measure different degrees of curarization.The duration of action of neuromuscular blockers has significant interindividual variability. If the investigators know how to measure the degree of curarization of a patient at a given time, it is difficult to know how long it will take to recover neuromuscular function.

The purpose of this study is to determine if the individual recovery of a patient can be predicted form data obtained at the beginning of his/her recovery curve. The investigators propose to record all neuromuscular transmission monitoring data in 100 patients. From these data, the investigators will try to develop an algorithm that would extrapolate the recovery curve of an isolated patient from the fist neuromuscular monitoring data.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing a surgical intervention with rocuronium
* Patients covered by the Belgian social security system

Exclusion Criteria:

* Allergy towards rocuronium
* 20\< Body Mass Index \<30
* Hepatocellular insufficiency, either clinical or abnormal liver tests
* Renal insufficiency, defined as Modification of diet in renal disease (MDRD) \<40ml / min or Cockgroft \<50ml / min
* Need to antagonize the curare

Primary outcomes:
measure: TOFScan recording
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: CHU Brugmann
Study officials:
affiliation: CHU Brugmann
name: Denis Schmartz, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ortega R, Brull SJ, Prielipp R, Gutierrez A, De La Cruz R, Conley CM. Monitoring Neuromuscular Function. N Engl J Med. 2018 Jan 25;378(4):e6. doi: 10.1056/NEJMvcm1603741. No abstract available.
citation: Heerdt PM, Sunaga H, Savarese JJ. Novel neuromuscular blocking drugs and antagonists. Curr Opin Anaesthesiol. 2015 Aug;28(4):403-10. doi: 10.1097/ACO.0000000000000209.
Clinical trial NCT01427764: Dentin Hypersensitivity Following Non-surgical Periodontal Therapy With Hand or Ultrasonic Instruments
Official title: Dentin Hypersensitivity Following Non-surgical Periodontal Therapy With Hand or Ultrasonic Instruments
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Periodontal Disease
Dentin Sensitivity
Keywords: Dentin sensitivity
Dental scaling
Ultrasonic
manual and ultrasonic instrumentation
Lead sponsor: Escola Bahiana de Medicina e Saude Publica
Sponsor class: OTHER
First posted: 2011-09-02
Enrollment: 14
Sex: ALL
Minimum age (years): 35
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Periodontal instrumentation aims to remove plaque and calculus from the root surface. Both manual and ultrasonic instruments have been used for such decontamination; however, establishing a healthy periodontium can result in adverse effects, such as dentin hypersensitivity. The aim of this study was to evaluate the effects of hand or ultrasonic instrumentation on dentin hypersensitivity in patients undergoing non-surgical periodontal treatment. For this controlled clinical trial of a "split mouth" design, 14 patients were selected with homologous teeth in the incisor to premolar region and probing depth ≥ 5 mm on the buccal aspect of the teeth. One side (control) was instrumented with hand instruments and the other side (test) with ultrasonic instruments. Dentin hypersensitivity was assessed in the baseline and during the follow 4 weeks after treatment, with a periodontal probe scratching the root surface and with an air jet. The patient's response was detected by a visual analog scale (VAS) of 10 cm.


Eligibility criteria: Inclusion Criteria:

* patients diagnosed with chronic or aggressive periodontitis, according to the American Academy of Periodontology classification15, requiring non-surgical periodontal treatment in at least two quadrants. These quadrants should present two contralateral and homologous teeth in the incisor to premolar region with probing depth ≥ 5 mm and bleeding on probing on the buccal surface.

Exclusion Criteria:

* presence of systemic illness or medication use (six months preceding the research), which could influence the response to periodontal treatment,
* performance of periodontal treatment including subgingival instrumentation in the six months preceding the study,
* performance of treatment for dentin hypersensitivity in the three months previous to the study,
* presence of periapical or pulpal changes,
* being under orthodontic treatment,
* smoking and
* pregnancy.

Primary outcomes:
Secondary outcomes:
measure: Change in the clinical attachment level
timeFrame: baseline and 4 weeks follow after treatment
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01767064: Nudging Guideline-concordant Antibiotic Prescribing Using Public Commitments
Official title: Nudging Guideline-concordant Antibiotic Prescribing Using Public Commitments
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acute Respiratory Infections (ARIs)
Keywords: ARIs, antibiotics, public commitment, quality improvement
Lead sponsor: University of Southern California
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
name: National Institute on Aging (NIA)
First posted: 2013-01-11
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Inappropriate antibiotic prescribing for acute respiratory infections (ARIs) persists despite decades of intervention efforts. Negative outcomes of inappropriate antibiotics include increased costs of care, adverse drug reactions, and rising prevalence of antibiotic-resistant bacteria. To address this public health problem, we apply the principles of commitment and consistency in an effort to influence clinician decision-making through the implementation of a low-cost behavioral "nudge" in the form of a simple public commitment device. Clinicians were asked to post in their exam room a signed letter indicating their commitments to reducing inappropriate antibiotic use for ARIs. Our hypothesis is that clinicians displaying the poster-sized commitment letters will decrease their inappropriate antibiotic prescribing for ARIs as compared to clinicians in the control condition (with no posted letter).


Eligibility criteria: Inclusion Criteria:

* Medical professionals licensed to provide care and prescribe medications (including antibiotics)
* Treating adult patients (18 years of age and older) from 5 Los Angeles community clinics

Exclusion Criteria:

* none

Primary outcomes:
measure: Inappropriate Antibiotic Prescribing for Patients With Acute Respiratory Infections (ARI)
timeFrame: up to 12 months post intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: QueensCare Family Clinics
state: California
Study officials:
affiliation: University of Southern California
name: Jason N Doctor, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Meeker D, Knight TK, Friedberg MW, Linder JA, Goldstein NJ, Fox CR, Rothfeld A, Diaz G, Doctor JN. Nudging guideline-concordant antibiotic prescribing: a randomized clinical trial. JAMA Intern Med. 2014 Mar;174(3):425-31. doi: 10.1001/jamainternmed.2013.14191.
Clinical trial NCT04216264: Pattern - Reach Aim 2
Official title: Pilot Adaptive Tool To Encourage Risk Reduction in iNfancy (PATTERN)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Keywords: infant
mother-baby
Lead sponsor: Duke University
Sponsor class: OTHER
Collaborators: name: National Institute on Minority Health and Health Disparities (NIMHD)
First posted: 2020-01-02
Enrollment: 28
Sex: ALL
Minimum age (years): 2
Maximum age (years): 2
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: PREVENTION

Brief summary: The purpose of this research study is to learn about different approaches to promoting healthy growth among infants, and understanding parents' likes and dislikes of an approach to reducing risk factors for obesity later in life. The study includes filling out some forms with questions about your baby and your thoughts about your baby's growth and health, and engaging in a pattern of changes in or prevention of risk factors in the first year of life. Parents will receive information about changes and some tools and materials to take home with them. Some parents may receive phone calls between visits as well. The study takes place from soon after birth through the infant's age of 9 months. The estimated total time of interaction between the study staff and parents during the study period is 4 hours.

Detailed description: As this is a dyad study, each dyad is considered to be a participant and demographic information will reflect the infant in the dyad, per parent report.

Eligibility criteria: Inclusion Criteria:

* Non-Hispanic black (as documented in MaestroCare) parents/caregivers with; infants ages 2 weeks to 2 months of age; infant birthweight between 2500g and 4000g; infant gestational age is at least 36 weeks

Exclusion Criteria:

* non-English-speaking; infant with serious disease or disorder affecting growth and nutrition

Primary outcomes:
measure: Number of Participants Satisfied or Very Satisfied With Information Given to Them, as Measured by Follow up Questionnaire
timeFrame: 3 to 6 months after baseline assessment
measure: Percentage of Successful Contacts With Families Via Telephone and/or in Clinic
timeFrame: 3 to 6 months after baseline assessment
Secondary outcomes:
measure: Percent of Participants Exclusively Breastfeeding at 4 Months Postnatal Age
timeFrame: 3 to 6 months after baseline assessment
measure: Percent of Participants Delaying Complementary Feeding Until 4 Months Postnatal Age
timeFrame: 3 to 6 months after baseline assessment
measure: Percent of Participants Reporting "Never" Engaging in Screentime While Feeding and With '0' Minutes of Active TV Watching at 4 Months Postnatal Age
timeFrame: 3 to 6 months after baseline assessment
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke University
state: North Carolina
Study officials:
affiliation: Duke University
name: Charles Wood
role: PRINCIPAL_INVESTIGATOR
References: