Clinical trial NCT00537602: Miglustat / OGT 918 in the Treatment of Cystic Fibrosis
Official title: Single Center, Double-blind, Randomized, Placebo-controlled, 2-period/2-treatment Crossover Study Investigating the Effect of Miglustat on the Nasal Potential Difference in Patients With Cystic Fibrosis Homozygous for the ΔF508 Mutation
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Cystic Fibrosis
Keywords: cystic fibrosis
miglustat
Zavesca
Actelion
nasal potential difference
transmembrane conductance regulator (CFTR)
Lead sponsor: Actelion
Sponsor class: INDUSTRY
First posted: 2007-10-01
Enrollment: 6
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Cystic fibrosis is a genetic disease caused by mutation of the cystic fibrosis transmembrane conductance regulator (CFTR). The purpose of the study is to investigate the effects of miglustat on CFTR function in cystic fibrosis patients.


Eligibility criteria: Inclusion Criteria:

* Aged 12 years and older
* Male or female
* Non-pregnant women who are to remain non-pregnant for 3 months after the end of the study: only women who are surgically sterile, who are in the menopause (no menstruation for at least one year) or those of childbearing potential who are using a reliable method of contraception. Reliable methods of contraception for female patients include the following:

  * Barrier type devices (e.g., female condom, diaphragm and contraceptive sponge) used ONLY in combination with a spermicide
  * Intrauterine devices
  * Oral contraceptive agent
  * Depo-Provera™ (medroxyprogesterone acetate)
  * Levonorgestrel implants Abstention, the rhythm method or contraception by the partner alone are NOT reliable methods of contraception.

For children, a reliable method of contraception must be considered, if appropriate.

* Accepting for the duration of the study and for 3 months thereafter to use a condom and not to procreate a child (males only)
* Cystic fibrosis patients homozygous for the ΔF508 mutation as confirmed by genetic test
* Signed informed consent prior to any study-mandated procedure

Exclusion Criteria:

* Any condition prohibiting the correct measurement of the NPD such as upper respiratory tract infection
* Acute upper respiratory tract or pulmonary exacerbation requiring antibiotic intervention within 2 weeks of screening
* Severe renal impairment (creatinine clearance \< 30 ml/min as per Cockroft and Gault)
* Female patients who will not undergo a pregnancy test prior to enrollment in the study
* History of significant lactose intolerance
* History of neuropathy
* History of cataracts or known increased risk of cataract formation
* Presence of clinically significant diarrhea (\>3 liquid stolls per days for \>7 days) without definable cause within 1 month prior to screening
* Any known factor of disease that might interfere with treatment compliance, study conduct or interruption of the results such as drug or alcohol dependence or psychiatric disease
* FEVI \<25% of predicted normal
* Oxygen saturation at rest \<88%
* Active or passive smoking as measured using the Smokelyzer®
* Hypersensitivity to miglustat or any excipients
* Planned treatment or treatment with another investigational drug or therapy (e.g., gene therapy) within 1 month prior to randomization

Primary outcomes:
measure: Change in nasal potential difference (NPD) in response to isoproterenol in chloride-free buffer in the presence of amiloride
timeFrame: Baseline (pre-dose on day 1) to end-of-treatment (day 8)
Secondary outcomes:
measure: Change in baseline NPD response
timeFrame: Baseline to end-of-treatment
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Corporacio Parc Tauli / Parc Tauli Hospital
Study officials:
affiliation: Actelion
name: Paul van Giersbergen, PhD
role: STUDY_DIRECTOR
affiliation: Corporacio Parc Tauli
name: Christian Domingo-Ribas, MD
role: PRINCIPAL_INVESTIGATOR
References: