Clinical trial NCT06004102: Medication Adherence in Kidney Transplant
Official title: Impact of Text Message Reminders on Immunosuppressive Medication Adherence Among Kidney Transplant Recipients: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Medication Adherence
Keywords: kidney transplantation
reminder text messages
medication adherence
surgical nursing
Lead sponsor: Akdeniz University Hospital
Sponsor class: OTHER
First posted: 2023-08-22
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Aims and Objective: The study aimed to assess the impact of text message reminders on medication adherence among kidney transplant recipients.

Background: One of the most common problems encountered in transplant patients is incompatibility with immunosuppressive drugs, one of the most important reasons for graft rejection.

Design: A randomized controlled trial was conducted from January to October 2021 and conducted in accordance with the Consolidated Standards of Reporting Trials 2010 guidelines.

Methods: This randomized controlled trial included a total of 100 patients receiving a kidney transplant, 50 in the intervention group and 50 in the control group. Patients in the intervention group were sent text message reminders four times a day during the 6th to 9th months after transplantation. Control patients received no such intervention. Tacrolimus concentrations in the bloodstream were monitored for all participants through measurements taken at months 7,8, and 9. Data collection tools included Sociodemographic and Descriptive Characteristics Form and Immunosuppressive Medication Adherence Scale.

Research hypotheses H1- Sending text message reminders improves immunosuppressive medication adherence in kidney transplant recipients.

H2- Utilization of text messages as reminders has a significant influence on tacrolimus blood profiles in kidney transplant recipients.

H3- There is a correlation between the scores from the Immunosuppressive Medication Adherence Scale and mean tacrolimus plasma levels in kidney transplant recipients.

H4- There is a correlation between the sociodemographic and descriptive characteristics of kidney transplant recipients and their mean scores from the Immunosuppressive Medication Adherence Scale.


Eligibility criteria: Inclusion Criteria:

* 18 years or older
* Being a recipient of a kidney transplant for the first time
* Being a kidney transplant recipient at post-transplant month 6 with scheduled follow-up until month 9
* Ongoing immunosuppressive drug therapy
* Absence of any disability that hinders communication
* No diagnosis of psychological and mental problems
* Being an active cell phone user
* Ability to read and write
* Voluntary participation in the research.

Exclusion Criteria:

* Hospitalization for any reason during the research period
* History of combined or dual organ transplantation.

Primary outcomes:
measure: The effect of sending reminder text messages on immunosuppressive medication adherence
timeFrame: baseline and 9 months
Secondary outcomes:
Other outcomes:
Locations:
city: Antalya
country: Turkey
facility: Akdeniz University
state: Konyaalti
Study officials:
References: