Clinical trial NCT01293110: Lower Urinary Tract Dysfunction Database
Official title: Database of Patients With Lower Urinary Tract Dysfunction Treated at the University of Zürich
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Neurogenic Bladder
Diseases of the Lower Urinary Tract: General Conditions
Keywords: urodynamics
neurogenic lower urinary tract dysfunction
neurological disease/injury
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2011-02-10
Enrollment: 7000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Ages Eligibility: minimum 18 years Genders Eligibility: female and male

Brief summary: Patients with neurological disease/injury often suffer from lower urinary tract symptoms, which frequently have a negative impact on the patients' health related quality of life. The prevalence of lower urinary tract dysfunction is high and the treatment is a challenge because available treatments may fail. In this study data of patients with lower urinary tract dysfunction treated at the University of Zürich, are prospectively and systematically collected in a database.

Detailed description: Lower urinary tract dysfunction is characterized by detrusor overactivity, detrusor sphincter dyssynergia, voiding dysfunction, stress incontinence, or a combination of these and frequently has a negative impact on the patients' health related quality of life. In addition, the treatment of lower urinary tract dysfunction is a challenge because conventional therapies may fail. Adequate treatment and long-term follow-up of lower urinary tract dysfunction is important to achieve/maintain continence and preserve renal function. Thus, we aim to prospectively collect clinical, video-urodynamic and radiological data of patients with neurogenic lower urinary tract dysfunction treated at the University of Zürich in a database.

Eligibility criteria: Inclusion Criteria:

* patient of Balgrist University Hospital
* patient of University Hospital Zürich
* urodynamic examination
* written informed consent

Exclusion Criteria:

* no written informed consent

Primary outcomes:
measure: Survival of the patients
timeFrame: first visit to death
Secondary outcomes:
Other outcomes:
Locations:
city: Zürich
country: Switzerland
facility: Spinal Cord Injury Center & Research, University of Zürich, Balgrist University Hospital
Study officials:
affiliation: Universitätsklinik Balgrist
name: Thomas M Kessler
role: PRINCIPAL_INVESTIGATOR
References:
citation: Walter M, Knupfer SC, Cragg JJ, Leitner L, Schneider MP, Mehnert U, Krassioukov AV, Schubert M, Curt A, Kessler TM. Prediction of autonomic dysreflexia during urodynamics: a prospective cohort study. BMC Med. 2018 Apr 13;16(1):53. doi: 10.1186/s12916-018-1040-8.
citation: Leitner L, Guggenbuhl-Roy S, Knupfer SC, Walter M, Schneider MP, Tornic J, Sammer U, Mehnert U, Kessler TM. More Than 15 Years of Experience with Intradetrusor OnabotulinumtoxinA Injections for Treating Refractory Neurogenic Detrusor Overactivity: Lessons to Be Learned. Eur Urol. 2016 Sep;70(3):522-8. doi: 10.1016/j.eururo.2016.03.052. Epub 2016 Apr 19.