Clinical trial NCT06600269: Cycling-Based Priming Coordination Training for Enhancing Ataxia Recovery and Brain Plasticity
Official title: The Effect of Cycling Priming Coordination Training on Ataxia and Brain Plasticity
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Spinocerebellar Ataxias
Keywords: Transcranial Magnetic Stimulation (TMS)
Gait
Motor Control
Motor Learning
Lead sponsor: Chang Gung University
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Effective walking and balance require not only lower limb muscle strength but also coordinated movement. For individuals with Spinocerebellar Ataxia (SCA), rehabilitation strategies targeting coordination are essential to improving mobility and reducing the burden on caregivers. However, evidence-based rehabilitation approaches for ataxia remain limited.

Recent studies suggest that improvements in motor learning are often accompanied by changes in cortical excitability. Abnormal cortical excitability in SCA patients may hinder rehabilitation efforts, yet priming strategies-such as exercise or specific stimuli-have been shown to enhance motor learning by modulating cortical excitability. Cycling exercise, in particular, has demonstrated the potential to improve coordination and influence cortical plasticity in individuals with SCA, making it a promising priming strategy for coordination training.

This clinical trial aims to:

1. Investigate the priming effect and neural mechanisms of acute cycling exercise on coordination training in patients with SCA.
2. Explore the long-term impact of priming cycling training on cortical plasticity and functional mobility in individuals with SCA.

This study seeks to provide insights into optimized rehabilitation interventions that could enhance the quality of life and independence for people with SCA.


Eligibility criteria: Inclusion Criteria:

- Clinical diagnosis of SCA.

Exclusion Criteria:

* Musculoskeletal injuries on legs
* Osteoporosis.
* Any peripheral or central nervous system injury or disease patients.

Primary outcomes:
measure: Overall Response Time
timeFrame: Baseline, 2 weeks and 4 weeks
measure: Overall Error Rate
timeFrame: Baseline, 2 weeks and 4 weeks
measure: Motor Evoked Potentials (MEPs)
timeFrame: Baseline, 2 weeks and 4 weeks
measure: Intracortical Facilitation (ICF)
timeFrame: Baseline, 2 weeks and 4 weeks
measure: Intracortical Inhibition (ICI)
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Total Scale for the Assessment and Rating of Ataxia (SARA) Score
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Total Berg Balance Scale (BBS) Score
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Total Time to Complete the Time Up and Go test (TUG test)
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Walking Speed
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Step Length
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Step Time
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Fatigue Level Measurement Using Multidimensional Fatigue Inventory (MFI)
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Sleep Quality Measurement Using Pittsburgh Sleep Quality Index (PSQI)
timeFrame: Baseline, 2 weeks, and 4 weeks
Secondary outcomes:
measure: Gait Speed Measurement Using 10-Meter Walk Test (10MWT)
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Double Support Time
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Single Support Time
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Swing Time
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Stance Time
timeFrame: Baseline, 2 weeks, and 4 weeks
measure: Cadence
timeFrame: Baseline, 2 weeks, and 4 weeks
Other outcomes:
Locations:
city: Taoyuan
country: Taiwan
facility: Chang Gung University
Study officials:
References: