Clinical trial NCT06648603: Citizen Action for Sustainable Dengue Control in Sub-Saharan Africa
Official title: Citizen Action for Sustainable Dengue Control in Sub-Saharan Africa
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dengue
Keywords: Aedes Aegypti
Vector control
Community based intervention
Participatory research
Dengue
Africa
Ivory Coast
Lead sponsor: Swiss Tropical & Public Health Institute
Sponsor class: OTHER
Collaborators: name: Centre Suisse de Recherches Scientifiques en Cote d'Ivoire
First posted: 2024-10-18
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Intervention model description: Cluster randomized trial with 2x2 factorial design - 40 clusters, 10 clusters per study arm (4 arms)
Primary purpose: PREVENTION

Brief summary: This project focuses on addressing arboviral outbreaks in Ivory Coast by involving local communities in the sustainable control of Aedes mosquitoes, utilizing scientific advice and environmental interventions. It will evaluate the impact of a participatory strategy on decreasing mosquito populations and the risk of virus transmission, aiming to provide insights for policy development on disease prevention.

Detailed description: This project targets the growing threat of Aedes mosquito-borne diseases such as dengue in Africa, focusing on the Anono and Gbagba communities in Abidjan, Ivory Coast, by transitioning from traditional control approaches to a community-driven strategy. It focuses on educating and involving communities in the design of sustainable mosquito management measures, such as breeding site eradication and adult mosquito capturing, with scientific experts guiding the efforts. The approach will entail conducting sociocultural surveys and interactive workshops while also encouraging local participation and multi-sectoral collaboration. A randomized controlled trial (RCT) will test this effectiveness of this novel integrated community-based participatory intervention approach in reducing the transmission of Aedes mosquito and other arboviruses. This effort seeks to develop a scalable model for arboviral disease control, promote community resilience, and inform policy recommendations for better public health outcomes in resource-constrained urban settings.

Eligibility criteria: Inclusion criteria:

1. Geographical location: households must be located within the designated clusters in the two districts involved in the trial.
2. Participation in cluster arms: households must belong to a cluster that is assigned to one of the four arms (1. Control, 2. Community-based larval source management, 3 Enhanced Aedes adults trapping (BG-GAT), 4. Enhanced Aedes adults trapping (BG-GAT) + Community-based larval source management).
3. Willingness to participate: households agreed to allow researchers to place mosquito traps and conduct larval and adult mosquito surveys.
4. Socio-Environmental Data: households must agree and provide consent to participate to the socio-environmental questionnaire.

Exclusion Criteria:

1. Outside of trial clusters: households located outside the designated clusters in the two districts were excluded.
2. Refusal to participate: households that do not consent to mosquito trap placement or surveys
3. Inaccessibility: households that are not accessible for regular visits or data collection (e.g., due to relocation or difficult terrain).

Primary outcomes:
measure: Aedes aegypti mean number per trap per day
timeFrame: Continuously during months 1-4 (baseline) and months 5-17 (trial)
Secondary outcomes:
measure: House index
timeFrame: Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)
measure: Pupal indices: pupae per person index, pupa index and pupae per hectare index
timeFrame: Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)
measure: Adults: parity rate
timeFrame: Continuously during months 1-4 (baseline) and months 5-17 (trial)
measure: Knowledge, attitudes, and practices on Dengue prevention among the population of Cocody-Bingerville
timeFrame: Before (month 1) the start of the trial and at the end of the trial (month 12)
measure: Mapping and describe Aedes aegypti breeding sites, focusing on their geographic and ecological characteristics. This mapping will be used to enhance targeted larval control efforts in these areas.
timeFrame: Before (month 1) the start of the trial and at the end of the trial (month 12)
measure: Container index
timeFrame: before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)
measure: Breteau index
timeFrame: Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)
Other outcomes:
Locations:
city: Abidjan
country: Côte D'Ivoire
facility: Centre Suisse de Recherches Scientifiques en Côte d'Ivoire
Study officials:
affiliation: Swiss Tropical & Public Health Institute
name: Pie Müller, PD, PhD
role: PRINCIPAL_INVESTIGATOR
References: