Clinical trial NCT06924164: Progressive Resistance Training for Adults With External Snapping Hip
Official title: Snappy Hip Trial: A Randomized Crossover Trial Comparing the Clinical and Cost-effectiveness of Progressive Resistance Training Compared to Usual Care on Pain for Adults With External Snapping Hip
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: External Snapping Hip
Coxa Saltans External
Keywords: External snapping hip
Progressive resistance training
Coxa saltans external
Exercise
Lead sponsor: University of Aarhus
Sponsor class: OTHER
Collaborators: name: University of Aarhus
First posted: 2025-04-11
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: External snapping hip is characterised by an audible and painful snap during hip movement among physical active people around 15-40 years old. Progressive resistance training has been suggested as a new potential treatment path in treating patients with external snapping hip. We conducted a feasibility study and found that patients reported less pain and improved their physical function, quality of life and muscle strength after 12 weeks of progressive resistance training. The overall aim of the project is to compare hip pain in patients with external snapping hip treated with progressive resistance training to a wait-and-see approach, in a randomised controlled trial. This study has the potential to establish a new and specific treatment option for patients with external snapping hip, to be used nationally and internationally.

Detailed description: This trial is an international multicentre randomised controlled assessor-blinded crossover trial, following the CONSORT guidelines. The intervention is a 12-week progressive resistance training programme, and the trial is designed with three follow-up time points. After the baseline test, the patients will be randomised in a 1:1 ratio to either the intervention or the control group using the Research Electronic Data Capture (REDCap) source hosted at Aarhus University. For the patients randomised to the intervention group, the first test will be the baseline test, conducted before the intervention. The second test will be conducted at week 13, and the third test after another 12 weeks of self-guided exercise, at week 25. Self-guided exercise is the period after the intervention, where the patients are recommended to continue training on their own. For the patients randomised to the control group, the first test will also be the baseline test, conducted before the waiting period. The second test will be conducted at week 13, and the third test after the 12 weeks of progressive resistance training at week 25. The primary outcome will be the change from baseline to the second follow-up, and the trial will be powered based on this period. The lasting effect of the intervention will be evaluated from baseline to the third follow-up test for the intervention group.

Eligibility criteria: Inclusion Criteria:

* Age 18-40 years
* Experienced lateral hip joint "snapping" with pain within the last 14 days
* Able to demonstrate the audible "snapping" or popping sound when the hip joint moves
* Capable of commuting to the training facility
* Proficient in reading and understanding Danish or English

Exclusion Criteria:

* Previous surgery on the affected hip
* Planned surgery on lower extremities within the trial period
* Neurological, rheumatoid or mental conditions affecting the hip function
* Planned vacation for more than 14 days within the intervention period
* Has performed systematic resistance training exercises for the hip muscles more than once a week within the last six months prior to inclusion
* Pregnancy

Primary outcomes:
measure: HAGOS Pain
timeFrame: Baseline, week 12 and week 24
Secondary outcomes:
measure: HAGOS
timeFrame: Baseline, week 12 and week 24
measure: UCLA-AS
timeFrame: Baseline, week 12 and week 24
measure: GPE
timeFrame: Baseline, week 12 and week 24
measure: Single leg hop test
timeFrame: Baseline, week 12 and week 24
measure: 30 second unilateral sit-to-stand test
timeFrame: Baseline, week 12 and week 24
measure: Number of training sessions the participant participated in
timeFrame: Throughout the study, summed in week 24
measure: Adverse events
timeFrame: Throughout the study, summed in week 24
Other outcomes:
measure: EQ-5D-5L
timeFrame: Baseline, week 12 and week 24
measure: iPCQ
timeFrame: Baseline, week 12 and week 24
measure: HUQ
timeFrame: Baseline, week 12 and week 24
measure: Usage of analgesics due to hip-related pain
timeFrame: Baseline, week 12 and week 24
Locations:
city: Aarhus N
country: Denmark
facility: Aarhus University Hospital
Study officials:
affiliation: Department of Orthopedic Surgery, Aarhus University Hospital, DK
name: Stig S Jakobsen, PhD
role: STUDY_DIRECTOR
affiliation: Department of Orthopedic Surgery, Aarhus University Hospital, DK
name: Lisa U Tønning, MHSc
role: PRINCIPAL_INVESTIGATOR
affiliation: Department of Clinical Medicine, Aarhus University, DK
name: Inger Mechlenburg, DMSc
role: STUDY_DIRECTOR
affiliation: Department of Public Health, Sports, Aarhus University, DK
name: Ulrik Dalgas, PhD
role: STUDY_DIRECTOR
affiliation: Department of Orthopedic Surgery, Aarhus University Hospital, DK
name: Troels Kjeldsen, PhD
role: STUDY_DIRECTOR
affiliation: Department of Physical Therapy, Boston University, Boston, US
name: Cara Lewis, PhD
role: STUDY_DIRECTOR
affiliation: Department of Orthopedic Surgery, Aarhus University Hospital, DK
name: Marin Lamm, MSc
role: STUDY_DIRECTOR
References: