louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04723121: Can We Predict of the Response of High Risk Non Muscle Invasive Bladder Cancer Patients to Intravesical Bacillus Calmette-Guerin? The Role of Immunological Markers
Official title: Can We Predict of the Response of High Risk Non Muscle Invasive Bladder Cancer Patients to Intravesical Bacillus Calmette-Guerin? The Role of Immunological Markers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bladder Cancer
Keywords: Bladder cancer
Bacillus Calmette-Guérin response
Prediction
Urinary cytokines
T cells
Recurrence
Progression
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2021-01-25
Enrollment: 204
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Intravesical BCG is the mainstay adjuvant management of high risk NMIBC. Adequacy of immune system stimulation is the determinant factor for patient response to BCG. Immunological markers for BCG-response could be helpful for urologists especially in the era of BCG shortage.

Objectives: To assess the predictive performance of different immunological markers on BCG-response in high risk NMIBC BCG-naïve patients.

Detailed description: Background: Intravesical BCG is the mainstay adjuvant management of high risk NMIBC. Adequacy of immune system stimulation is the determinant factor for patient response to BCG. Immunological markers for BCG-response could be helpful for urologists especially in the era of BCG shortage.

Objectives: To assess the predictive performance of different immunological markers on BCG-response in high risk NMIBC BCG-naïve patients.

Eligibility criteria: Inclusion Criteria:

* patients with primary or recurrent NMIBC for whom primary TURBT was done.

Exclusion Criteria:

1. Patients with previous BCG instillation,
2. benign pathology
3. Variant histology
4. Non urothelial carcinoma,
5. concommitent upper tract urothelial tumors, detrusor muscle invasion
6. low or intermediate risk NMIBC

Primary outcomes:
measure: Initial BCG complete response
timeFrame: 3 months
measure: Recurrence
timeFrame: 1 year
measure: Progression
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Urology and Nephrology Center
state: DK
Study officials:
affiliation: Urology and Nephrology Center
name: Amr A Elsawy
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01311921: Children's Susceptibility to Enterovirus 71 in Different Areas of Taiwan
Official title: The Specific Aims Are to Find Factors Associated With Different Severe/Fatal Incidences in Different Areas of Taiwan. We Will do 1. Comparison of Gene Variants in EV71 Cases With Different Severity and Normal Children in Different Areas of Taiwan to Find Susceptible Genes and Genetic Polymorphism Related to the Clinical Outcomes 2. Social, Behavioral and Environmental Factors Related to EV71 Infections in Different Areas of Taiwan
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Enterovirus 71, Host Genetics, Social, Behavior, Environmental Factors
Keywords: enterovirus 71, host genetics, social, behavior, environmental factors
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2011-03-10
Enrollment: 200
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Symptoms very like Enterovirus type 71 of hand, foot, and mouth disease or Herpangina,

Brief summary: EV71 has caused large epidemics with lots of fatal cases and cases with sequelae. However, the clinical syndromes and severity of the same EV71 strain are very diverse, ranging from asymptomatic (71%) to fatal (0.05%) disease, and the pathogenesis remains unknown. In addition, the severe or fatal case incidence varies significantly differently in different areas of Taiwan. Although some viral virulence studies were performed, no clear viral virulence factor has been found. Therefore, host factors may be important to the clinical outcomes of EV71 infections. In addition, there were significantly different incidences of severe or fatal cases in different areas of Taiwan, for example, significantly more fatal or severe cases occurred in the central or southern Taiwan in comparison with in northern Taiwan. Whether this is related to host factors, social, behavioral or environmental factors remains unanswered. To find the most important factors associated with EV71 susceptibility, a thorough study involving genetics, social, behavioral or environmental factors among different areas of Taiwan is warranted and the findings will provide future prevention of EV71 and give help on early precaution and treatment of EV71.

Detailed description: The specific aims are to find factors associated with different severe/fatal incidences in different areas of Taiwan. We will do

1. Comparison of gene variants in EV71 cases with different severity and normal children in different areas of Taiwan to find susceptible genes and genetic polymorphism related to the clinical outcomes
2. Social, behavioral and environmental factors related to EV71 infections in different areas of Taiwan

Eligibility criteria: Inclusion Criteria:

- Enterovirus type 71

Exclusion Criteria:

- not Enterovirus type 71

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00663221: Study of the Osteoprotector Effects of a Milk Product Based on Anthocyans and Enriched in Calcium and Vitamin D
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Osteoporosis
Keywords: Osteoporosis prevention
Lead sponsor: Elvir SAS
Sponsor class: INDUSTRY
Collaborators: name: University Hospital, Clermont-Ferrand
First posted: 2008-04-22
Enrollment: 56
Sex: FEMALE
Minimum age (years): 50
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: We hypothesize that anthocyans with calcium and vitamin D have a positive effect on bone reshaping in menopausal women.


Eligibility criteria: Inclusion Criteria:

* Women
* Aged between 50 and 65 years
* Between 1 and 5 years menopause
* IMC between 19 and 30 kg/m²

Exclusion Criteria:

* Medical Treatment for bone metabolism
* Vitamin D not including in the range of 20nmoles\<25(OH)\<100nmoles/l
* Vegan and vegetarian diet
* Regular consumption of food supplementary benefits
* Lactose intolerance
* While dieting

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand
Study officials:
References:
Clinical trial NCT05347121: Difficult Airway and Ultrasonographic Evaluation
Official title: Evaluation of Neck Ultrasound Measurements as a Difficult Airway Signification
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Difficult Airway
Lead sponsor: Kocaeli University
Sponsor class: OTHER
First posted: 2022-04-26
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study included American Society of Anesthesiologists (ASA) physical status I-II-III, 120 patients over the age of 18 who would be operated under general anesthesia.

Brief summary: In this study, it was planned to evaluate the preoperative neck ultrasonography measurements as a predictor of difficult airway in adult patients who will undergo elective surgery under general anesthesia.


Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists (ASA) physical condition I-II-III

Exclusion Criteria:

* . Uncooperative patients,
* pregnant women,
* patients who have had head and neck trauma/surgery,
* patients with a known history of difficult airway

Primary outcomes:
measure: epiglottis-skin thickness
timeFrame: one month
Secondary outcomes:
Other outcomes:
Locations:
city: Kocaeli̇
country: Turkey
facility: Kocaeli Üniversitesi
Study officials:
References:
Clinical trial NCT01353521: Contrast-enhanced Ultrasound for the Evaluation of Complex Renal Cysts
Official title: Contrast-enhanced Ultrasound for the Evaluation of Complex Renal Cysts
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Complex Renal Cyst
Keywords: complex renal cysts
Contrast enhanced ultrasound
Lead sponsor: St. Joseph's Healthcare Hamilton
Sponsor class: OTHER
Collaborators: name: McMaster University
First posted: 2011-05-13
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Complex renal cysts are often incidentally detected on imaging. The differential diagnosis of the complex renal cyst includes various benign cystic lesions, which are based on the Bosniak classification scheme. Currently the standard of care in evaluating a complex renal cyst is using a contrast-enhanced computed tomography (CT) scan, or a contrast-enhanced magnetic resonance imaging (MRI) scan. Since both of these modalities present adverse events due to frequent high doses of radiation, a technique such as a contrast-enhanced ultrasound (CEUS) can be used to obtain the same results, without having to impose high doses of radiation upon a patient.

Detailed description: By evaluating complex renal cysts using a contrast-enhanced ultrasound (CEUS), it can be established as to whether or not the results are better, the same, or worse, when compared to CT and/or MRI scans.

Eligibility criteria: Inclusion Criteria:

* at least 18 years old and capable of giving informed consent
* all patients undergoing CT evaluation of complex renal cysts at our centre (either initially or in follow-up)
* A complex renal cyst defined as Bosniak IIF, III or IV

Exclusion Criteria:

* pregnant patients
* patients with contrast allergies
* patients with non-cystic, solid renal masses
* patients with simple cysts (Bosniak class I and II)

Primary outcomes:
measure: concordance between CEUS and CT
timeFrame: (Baseline, follow up at 3, 6, 9, & 12 months)
Secondary outcomes:
measure: histopathological diagnosis after surgery of complex renal cysts
timeFrame: Baseline and every three months until the end of study.
measure: Average percent difference of CEUS vs CT imaging
timeFrame: Baseline imaging (CEUS 14 days within a CT scan)
Other outcomes:
Locations:
city: Hamilton
country: Canada
facility: St. Joseph's Healthcare Hamilton
state: Ontario
Study officials:
affiliation: McMaster Institute of Urology - St. Joseph's Healthcare Hamilton
name: Anil Kapoor, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: McMaster Institute of Urology - St. Joseph's Healthcare Hamilton
name: Christopher Allard, MD
role: STUDY_CHAIR
References:
Clinical trial NCT06732921: Recovery Control Tower Feasibility Pilot
Official title: Protocol for a Pilot Interventional Study Evaluating the Efficiency and Safety of a Telemedicine Solution for the Post-Anesthesia Care Unit
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Elective Surgery
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2024-12-13
Enrollment: 8500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: A pilot study in perioperative telemedicine that aims to demonstrate the efficiency, and safety of integrating telemedicine into the PACU environment. This pilot study will expand on our previously conducted proof-of-concept study for a telemedicine solution in the PACU. If this pilot study proves to be successful, the study team intends subsequently to expand such a telemedicine solution to multiple clinical locations.


Eligibility criteria: * Adults (18 years and older)
* Undergoing elective surgery at Barnes Jewish Hospital in St. Louis, Missouri will be enrolled.

Primary outcomes:
measure: Time spent in PACU
timeFrame: Day of surgery
Secondary outcomes:
measure: Time to PACU sign-out by anesthesia clinician
timeFrame: From the time the patient enters post-anesthesia care unit until time patient leaves post-anesthesia care unit, assessed up to 24 hours after surgery.
measure: Pain score in PACU
timeFrame: From the time the patient enters post-anesthesia care unit until time patient leaves post-anesthesia care unit, assessed up to 24 hours after surgery.
measure: PONV status in PACU
timeFrame: From the time the patient enters post-anesthesia care unit until time patient leaves post-anesthesia care unit, assessed up to 24 hours after surgery.
measure: Clinician interactions - Number of contacts RCT clinicians receive from PACU clinicians
timeFrame: From the time the patient enters post-anesthesia care unit until time patient leaves post-anesthesia care unit, assessed up to 24 hours after surgery.
measure: Clinician interactions - Number of contacts RCT clinicians make to PACU clinicians for on-the-ground intervention
timeFrame: From the time the patient enters post-anesthesia care unit until time patient leaves post-anesthesia care unit, assessed up to 24 hours after surgery.
measure: Safety events - Return to hospital
timeFrame: 24 hours
measure: Safety events - Number of participants with elevation of care
timeFrame: 24 Hours
measure: Safety events - Number of participants with administration of rescue drugs
timeFrame: 24 Hours
measure: Safety events - Significant event notes
timeFrame: 24 Hours
measure: PACU clinician satisfaction
timeFrame: Through study completion, an average of 1 year
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
Study officials:
affiliation: Washington University School of Medicine
name: Michael S Avidan, MBBcH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01330121: Bridging the Gap by Transitional Care
Official title: Pharmacist Discharge Counseling: Bridging the Gap by Transitional Care
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetes Mellitus Type 2
Keywords: Adherence with discharge diabetes medications
Diabeted mellitus type 2 greater than one year
Patient with provider and prescriptions filled within CCHS
Lead sponsor: Cook County Health
Sponsor class: OTHER_GOV
First posted: 2011-04-06
Enrollment: 130
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of the study is to evaluate patient adherence with discharge diabetes medications up to 120 days following pharmacist counseling during hospital stay about diabetes self management

Detailed description: It is a prospective, randomized, controlled Study. Patients randomized in a 1:1 ratio to pharmacist counseling or standard of therapy prior to discharge.

Standard therapy: Nurses distribute a education pamphlet on diabetes.

Pharmacist Counseling includes but is not limited to:

* Reviewing and explaining their medications (dosing, side effects, route)
* Reviewing symptoms and complications of hyper and hypoglycemia
* Defining glycemic \& non-glycemic goal levels
* Explaining the importance of compliance with medications \& appointments
* Educating on the basics of nutrition and physical activity

Eligibility criteria: Inclusion Criteria:

* Males or females
* 18 to 85 years of age
* Historical diagnosis of type 2 diabetes mellitus greater than one year
* HbA1c concentration ≥ 8%
* Discharged from general medicine unit of John H. Stroger Jr, Hospital of Cook County
* Patient with provider and prescriptions filled within CCHS

Exclusion Criteria:

* Type 1 diabetes mellitus
* Pregnancy
* Major illness or debility, that prohibits the subject from participating in the study
* History of any hemoglobinopathy that may affect determination of HbA1c
* Non-English speaking patients

Primary outcomes:
measure: Adherence with discharge diabetes medications up to 120 days following pharmacist counseling during hospital stay about diabetes self management
timeFrame: up to 120 days
Secondary outcomes:
measure: Change in A1c after 90 days
timeFrame: up to 90 days
measure: Change in BP after 90 days
timeFrame: up to 90 days
measure: Change in lipids after 90 days
timeFrame: up to 90 days
Other outcomes:
Locations:
city: Chicago
country: United States
facility: John H. Stroger Jr. Hospital of Cook County
state: Illinois
Study officials:
affiliation: John H. Stroger Hospital of Cook County, Division of Endocrinology
name: Leon Fogelfeld, M.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: John H. Stroger Hospital of Cook County, Department of Pharmacy
name: Mansi Shah, PharmD
role: PRINCIPAL_INVESTIGATOR
affiliation: John H. Stroger Hospital of Cook County, Department of Pharmacy
name: CaTanya Norwood, R.PH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04274621: The Application Value of Non-contact Infrared Thermometers in Temperature Screening in the General Population
Official title: The Application Value of Non-contact Infrared Thermometers in Temperature Screening in the General Population: a Real-world, Prospective, Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Non-contact Infrared Thermometer; Rapid Screening
Lead sponsor: Ningbo No. 1 Hospital
Sponsor class: OTHER
First posted: 2020-02-18
Enrollment: 572
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients, family members of patients, and medical staff

Brief summary: The first epidemic of 2019 novel coronavirus (2019-nCoV)-infected pneumonia(NCIP) in Wuhan, China, has attracted global attention because of its strong transmission ability and certain fatality. Analyzing the clinical data of hospitalized patients with 2019-nCoV infection, the current studies found that fever, fatigue and dry cough were common symptoms, and 43.8% of the patients showed fever before admission. Some scholars emphasize that the most effective means to control the outbreak are early detection, early isolation, early diagnosis and early treatment. In the face of the pressure that a large number of people need rapid screening and the deficiency that the forehead temperature measurement is easily affected by the environment, the investigators would like to explore the accuracy and advantages of wrist temperature measurement in different environments and conditions in this period. And determine the thresholds of non-contact infrared thermometer for the screening of patients with fever, in order to provide clinical indicators for further detection of patients with suspected fever.


Eligibility criteria: Inclusion Criteria:

* patients, family members of patients, and medical staff

Exclusion Criteria:

* age \<= 18 years
* Wearing hearing aid, having a cerumen
* Soft tissue infection, trauma patients
* Missing data

Primary outcomes:
measure: The Comparison of accuracy between wrist temperature and forehead temperature.
timeFrame: cross-sectional analyses in 2020
Secondary outcomes:
Other outcomes:
Locations:
city: Ningbo
country: China
facility: Ningbo first hospital
state: Zhejiang
Study officials:
References:
Clinical trial NCT04910321: Hangzhou Hospital Staff Cohort
Official title: Hangzhou Hospital Staff Cohort
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Diabetes Mellitus
Cardiovascular Diseases
Metabolic Syndrome
Lead sponsor: Westlake University
Sponsor class: OTHER
Collaborators: name: First People's Hospital of Hangzhou
name: Hangzhou Women's Hospital
name: Red Cross Hospital, Hangzhou, China
First posted: 2021-06-02
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who are serving staffs from the Hangzhou Frirst People's Hospital, Hangzhou Women's Hospital, and Hangzhou Red Cross Hospital are recruited.

Brief summary: The Hangzhou Hospital Staff Cohort (HHSC) is a prospective cohort study among staffs from three hospitals located in Hangzhou, China, including the Hangzhou First People's Hospital, Hangzhou Women's Hospital, and Hangzhou Red Cross Hospital. Participants recruitment and baseline survey including anthropometric, lifestyle and clinical measurement, as well as biological samples collection are initiated in January 2021. Recruited hospital staff are followed up every year during the medical examination organized by their employer. The primary aim of the HHSC study is to investigate the prospective associations of diet, physical activities, sleep, and other lifestyle factors with the long-term metabolic health of the hospital staffs. The secondary aim of the HHSC study is to integrate multi-omics data including genomics, metabolomics, proteomics and microbiome by a machine learning algorithm, to probe into the complex mediating roles of gene, metabolism and gut microbiota linking lifestyle factors with metabolic health.


Eligibility criteria: Inclusion Criteria:

* Participants aged 18 years or older
* Serving staffs of designated hospitals

Exclusion Criteria:

* Participants with cancer
* Participants with other serious medical disorders

Primary outcomes:
measure: Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L
timeFrame: 3 years after enrollment
measure: Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L
timeFrame: 6 years after enrollment
measure: Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L
timeFrame: 9 years after enrollment
Secondary outcomes:
measure: Change of body mass index
timeFrame: Change from baseline at 3 years
measure: Change of body mass index
timeFrame: Change from baseline at 6 years
measure: Change of body mass index
timeFrame: Change from baseline at 9 years
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Hangzhou First People's Hospital
state: Zhejiang
Study officials:
References: