Clinical trial NCT06743802: The Effect of Coenzyme Q10 in Preventing Pain After Thoracoscopic Surgery
Official title: The Effect of Coenzyme Q10 in Preventing Pain After Thoracoscopic Surgery: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: Postoperative Pain
Lead sponsor: The Second Affiliated Hospital of Chongqing Medical University
Sponsor class: OTHER
First posted: 2024-12-20
Enrollment: 264
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study aimed to assess the effectiveness of Coenzyme Q10 in preventing both acute and chronic pain following thoracoscopic surgery, with a focus on its potential benefits in reducing the incidence and severity of pain.


Eligibility criteria: Inclusion Criteria:

* Aged 18-75 years;
* American Society of Anesthesiology (ASA) physical status classification I-III;
* Scheduled for elective lung resection surgery under thoracoscopy;
* Voluntarily opting for patient-controlled intravenous analgesia;
* Willing to participate in this trial after consultation with the patient or their family and signing the informed consent form.

Exclusion Criteria:

* History of previous thoracotomy or thoracoscopic surgery;
* Patients converted to open thoracotomy intraoperatively;
* Severe hepatic or renal dysfunction;
* History of substance abuse;
* Pregnancy or breastfeeding;
* History of chronic pain;
* Use of coenzyme Q10 for more than one month;
* Allergy to coenzyme Q10;
* Patients unable to communicate or cooperate.

Primary outcomes:
measure: The incidence of chronic postsurgical pain
timeFrame: from the end of surgery to 3 months after surgery
Secondary outcomes:
measure: The incidence of acute postoperative pain with a score ≥4
timeFrame: from the end of surgery to 6 hours,12 hours, 24 hours , 48 hours and 72 hours after surgery.
measure: The severity of acute postoperative pain
timeFrame: from the end of surgery to 6 hours,12 hours, 24 hours , 48 hours and 72 hours after surgery.
measure: The severity of chronic postsurgical pain
timeFrame: from the end of surgery to 3 months after surgery
measure: The incidence of neuropathic pain
timeFrame: from the end of surgery to 3 months after surgery
measure: The frequency of postoperative rescue analgesic use
timeFrame: from the end of surgery to 6 hours,12 hours, 24 hours , 48 hours and 72 hours after surgery.
measure: The dose of analgesic use
timeFrame: from the end of surgery to 6 hours,12 hours, 24 hours and 48 hours after surgery.
measure: The quality of recovery score at 3 days Postoperatively
timeFrame: from the end of surgery to 3 days.
measure: Health related quality of life score at 3 months Postoperatively
timeFrame: from the end of surgery to 3 months after surgery.
measure: Postoperative length of hospital stay
timeFrame: from end of surgery to about 3 to 7 days after surgery.
measure: The incidence of adverse reactions
timeFrame: From admission to 3 month post-discharge
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Guangyou Duan
state: Chongqing
Study officials:
References: