louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05559190: Effect of a Preoperative Pulsed Electromagnetic Field and Abdominal Exercises on Muscle Strength Post Ventral Hernioplasty
Official title: Effect of Preoperative Pulsed Electromagnetic Field and Abdominal Exercises on Muscle Strength Post Ventral Hernioplasty
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hernia, Ventral
Keywords: pulsed electromagnetic field
abdominal exercises
ventral hernia repair
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-09-29
Enrollment: 60
Sex: ALL
Minimum age (years): 25
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to investigate the impact of a preoperative pulsed electromagnetic field and abdominal exercises on muscle strength post ventral hernioplasty.

Detailed description: Sixty patients, 25-40 years old, diagnosed with a ventral hernia and consulted for surgical hernia repair, preoperatively, were randomly assigned either into pulsed electromagnetic therapy and graduated abdominal strengthening exercises group (group A), graduated abdominal strengthening exercises group (group B), pulsed electromagnetic therapy group (group C) or group D who is instructed to presume in normal activities of daily living preoperatively, without any abdominal exercises or PEMF. All treatment interventions were applied at a frequency of three sessions per week for six weeks preoperatively. Abdominal muscle torque was measured by a biodex isokinetic dynamometer preoperatively at baseline and after six weeks of intervention and after four months postoperatively.

Eligibility criteria: Inclusion Criteria:

* Being subjects of both genders.
* Between the age of 25-40 years.
* Diagnosed with a ventral hernia (Grade II \& III) based on surgeon assessment and desired an elective surgical repair.
* Able to act in the abdominal training program.

Exclusion Criteria:

* Patients with a strangulated hernia.
* Bowel obstruction, peritonitis or perforation.
* Urgent surgery indication.
* Less than one-year abdominal surgery.
* Infection (local or systemic).
* Orthopedic problem, or neurological impairment that interfere with patient ability to act in the abdominal training program.
* Pregnant women.

Primary outcomes:
measure: the change in the abdominal muscle torque
timeFrame: Baseline and six weeks after the intervention preoperatively and after four weeks postoperative as follow up
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Shaimaa Mohamed Ahmed Elsayeh
state: New Cairo
Study officials:
affiliation: Lecturer at Faculty of Physical Therapy, Cairo University
name: Shaimaa MA Elsayeh, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04919590: Text Message Quit Vaping Intervention for Adolescents
Official title: Text Message Quit Vaping Intervention for Adolescents
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vaping
Cessation, Tobacco
Keywords: Vaping cessation
Mobile intervention
Adolescents
Lead sponsor: Truth Initiative
Sponsor class: OTHER
First posted: 2021-06-09
Enrollment: 1681
Sex: ALL
Minimum age (years): 13
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This research study, conducted by Truth Initiative, will help us learn how text messaging can help adolescents between 13 and 17 years of age quit vaping.

Detailed description: The Teen Quit Vaping Study (QVS Teen) is a comparative effectiveness trial to evaluate the effectiveness of a quit vaping text message program in promoting abstinence from e-cigarettes among young users aged 13-17. This study is a 3-arm randomized controlled trial conducted among young users aged 13-17 recruited through online channels. Participants will be randomized to a quit vaping text message intervention, an assessment-only control condition, or a waitlist control condition. The primary aim is to examine 30-day point prevalence abstinence at 7-months post enrollment (roughly corresponds to 6-months post-treatment).

Eligibility criteria: Inclusion Criteria:

* Age 13-17
* Past 30-day use of e-cigarettes containing nicotine
* Interest in quitting e-cigarette use in the next 30 days
* US residence

Exclusion Criteria:

* Failure to confirm mobile number after initial sign-up

Primary outcomes:
measure: Self-reported 30-day Point Prevalence Abstinence
timeFrame: 7 months post enrollment
Secondary outcomes:
Other outcomes:
Locations:
city: Washington
country: United States
facility: Truth Initiative
state: District of Columbia
Study officials:
References:
citation: Graham AL, Cha S, Jacobs MA, Amato MS, Funsten AL, Edwards G, Papandonatos GD. A Vaping Cessation Text Message Program for Adolescent E-Cigarette Users: A Randomized Clinical Trial. JAMA. 2024 Sep 3;332(9):713-721. doi: 10.1001/jama.2024.11057.
Clinical trial NCT01553890: Empirical Comparative Study of Variation Blood Level Antibody Vitamin D at Scleroderma (SSc) Patients Compared Healthy Peoples
Official title: Empirical Comparative Study of Variation Blood Level Antibody Vitamin D at SSc Patients Compared Healthy Peoples
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Scleroderma
Keywords: SSc= scleroderma
ICF+ informed consent form
age 18 to 85
healthy
Lead sponsor: Meir Medical Center
Sponsor class: OTHER
First posted: 2012-03-14
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The aim is to find the presence of anti vitamin D antibodies in scleroderma patients and compare with control. A second goal is anti vitamin D levels in serum of scleroderma patients in relation to the clinical manifestations of the disease.

Detailed description: Blood samples from 30 scleroderma patients compared to 30 healthy peoples to reach the target of variation of the blood level vitamin D antibody between this groups

Eligibility criteria: Inclusion Criteria:

study group

1. patients with SSc
2. age - 18 years old and older
3. sign ICF control group - healthy people

Primary outcomes:
measure: Presence of anti vitamin D antibodies in scleroderma patients compared with control
timeFrame: March 2013 (up to one year)
Secondary outcomes:
measure: Anti vitamin D presence and levels in serum in relation to the clinical manifestations of scleroderma
timeFrame: March 2013 (up to one year)
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02146690: Effect of Osteopathic Manipulative Treatment on Reduction of Pain in Complicated Newborns: RCT
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Prematurity
Keywords: pathology
newborn
osteopathic manipulative treatment
pain
Lead sponsor: European Institute for Evidence Based Osteopathic Medicine
Sponsor class: OTHER
First posted: 2014-05-26
Enrollment: 225
Sex: ALL
Minimum age (years): 26
Maximum age (years): 40
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the present 3 armed placebo control parallel group randomized control trial is to explore the extent to which osteopathic manipulative treatment is effective in reducing pain in a population of complicated newborns.


Eligibility criteria: Inclusion Criteria:

* newborns born in the same hospital
* either gender
* diagnosis of any pathological/clinical medical condition

Exclusion Criteria:

* lack of guardian consent
* newborn transferred to/from other hospital
* lack of any of the inclusion criteria

Primary outcomes:
measure: baseline changes in pain score using Premature Infant Pain Profile
timeFrame: baseline and end of hospitalization, expected hospitalization 4 weeks
Secondary outcomes:
measure: Length of stay in days
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 4 weeks
Other outcomes:
measure: Neonatal Intensive Care Unit cost
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 4 weeks
Locations:
city: Pescara
country: Italy
facility: Pescara Civil Hospital
Study officials:
References:
Clinical trial NCT00845390: Patient Expectations After Implantable-cardioverter Defibrillator (ICD) Implantation
Official title: Patient Expectations After ICD Implantation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Defibrillators, Implantable
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
First posted: 2009-02-18
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: ICD Clinic patients

Brief summary: This study will be a qualitative survey to understand the expectations of defibrillator patients with regards to their device. It is unknown what ICD (implantable-cardioverter defibrillator) patients understand about their device and its purpose, thus we will be talking to them about their device. Also, we will be interested in studying their beliefs on how the ICD impacts their life expectancy and quality of life.


Eligibility criteria: Inclusion Criteria:

* All patients are eligible for inclusion. We hope to acquire a wide range of ages but are not limited to a specific set.

Exclusion Criteria:

* Non-English speakers will be excluded.

Primary outcomes:
measure: Why did you have an ICD implanted?
timeFrame: after ICD implantation
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: UCSF Arrhythmia and Device Clinic
state: California
Study officials:
affiliation: University of California, San Francisco
name: Rita F Redberg, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06830590: Study of Molecular Characterisation of Early Operable Primary Breast Cancer in Pakistani Population
Official title: Study of Molecular Characterisation of Early Operable Primary Breast Cancer in Pakistani Population
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Breast Cancer
Molecular Pathway Deregulation
Treatment
Keywords: Breast cancer
Molecular characterisation
Lead sponsor: Liaquat University of Medical & Health Sciences
Sponsor class: OTHER
First posted: 2025-02-17
Enrollment: 300
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population are women with early operable primary breast cancer underwent surgery without any prior treatment.

Brief summary: This study is looking at the biological characteristics of early operable primary breast cancer in Pakistani Population by using IHC


Eligibility criteria: Inclusion Criteria:

* Women with confirmed diagnosis of breast cancer without history of taking neoadjuvant therapy Good quality tumour samples available for IHC

Exclusion Criteria:

* patients received pre-operative chemotherapy or radiotherapy

Primary outcomes:
measure: Breast cancer specific survival in correlation with molecular pattern
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Jamshoro
country: Pakistan
facility: Binafsha M Syed
Study officials:
affiliation: Liaquat University of Medical & Health Sciences, Jamshoro
name: Binafsha Manzoor M Syed, MBBS, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05570890: Immediate Effect of Electrical Noise Stimulation on Neuromuscular Adaptation of Balance
Official title: Immediate Effect of Electrical Noise Stimulation on Neuromuscular Adaptation During Single-Leg Stance in Healthy Young
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Balanced
Electroencephalography
Electromyography
Keywords: Center of pressure
Electroencephalography
Electromyography
H reflex
Electrical noise stimulation
Lead sponsor: National Yang Ming Chiao Tung University
Sponsor class: OTHER
First posted: 2022-10-07
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Noise stimulation had an immediate effect on improving balance control. The present study aimed to clarify the immediate neuromuscular adaptation induced by noise stimulation and find the correlation between neuromuscular adaptation and functional performance.

Detailed description: The mechanism behind noise stimulation is called Stochastic Resonance which improves the detectivity of sensory input with the presence of noise, making sub-sensory threshold input detectable. Noise stimulation had been proved to improve postural control, Ia afferent sensitivity, and muscle activity of the tibialis anterior. With this evidence of the effect of noise stimulation on balance enhancement, the neuromuscular adaptation induced by noise stimulation has not been researched yet. Therefore, the present study aims to clarify the immediate effect of noise on neuromuscular regulation during postural control.

Eligibility criteria: Inclusion Criteria:

* age between 20 and 40 years old
* without ankle injury history in 1 year
* without musculoskeletal or neurological diseases that would affect balance performance
* without visual impairment (except vision correction or no visual problems)
* without vestibular impairment.

Exclusion Criteria:

* subject who cannot tolerate the cutaneous electrical stimulation to induce H reflex
* single-leg stance (SLS) without support is shorter than 80 secs

Primary outcomes:
measure: Mean sway path of the center of pressure
timeFrame: 40 seconds under each condition
measure: Mean sway velocity of the center of pressure
timeFrame: 40 seconds under each condition
measure: Cortical excitability
timeFrame: 40 seconds under each condition
measure: Spinal reflex excitability
timeFrame: 40 seconds under each condition
measure: Co-activation index
timeFrame: 40 seconds after each condition
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Yang-Ming University
Study officials:
affiliation: National Yang Ming Chiao Tung University
name: Li-Wei Chou, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03645590: Stroke Ready - Optimizing Acute Stroke Care
Official title: Stroke Ready - Optimizing Acute Stroke Care
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke, Acute
Stroke
Lead sponsor: University of Michigan
Sponsor class: OTHER
Collaborators: name: National Institute on Minority Health and Health Disparities (NIMHD)
First posted: 2018-08-24
Enrollment: 5970
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SEQUENTIAL
Intervention model description: Stroke Ready is a stepped wedge design to be delivered to each of the four Flint community quadrants over the course of 2 years.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The study aims to increase acute stroke treatment rates in Flint, Michigan through a two-pronged approach of hospital and community level interventions. It also aims to inform future stroke preparedness interventions by exploring the relative importance of hospital optimization and community interventions.


Eligibility criteria: Inclusion criteria:Adult stroke patients who presented to one of three hospitals in the Flint community.

Primary outcomes:
measure: Acute stroke treatment rate (tPA)
timeFrame: Time frame: 11 years of data will be reviewed
Secondary outcomes:
measure: Number of emergency department arrivals by ambulance
timeFrame: Time frame: 11 years of data will be reviewed
Other outcomes:
Locations:
city: Flint
country: United States
facility: Flint Communiy
state: Michigan
Study officials:
affiliation: University of Michigan
name: Lesli Skolarus, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Robles MC, Springer MV, Corches CL, Burke JF, Lin CC, Oliver A, Skolarus LE. Stroke Ready Very Brief Intervention Improves Immediate Postintervention Stroke Preparedness. Circ Cardiovasc Qual Outcomes. 2020 Dec;13(12):e006643. doi: 10.1161/CIRCOUTCOMES.120.006643. Epub 2020 Nov 26. No abstract available.
citation: Skolarus LE, Sales AE, Zimmerman MA, Corches CL, Landis-Lewis Z, Robles MC, McBride AC, Rehman N, Oliver A, Islam N, Springer MV, O'Brien A, Bailey S, Morgenstern LB, Meurer WJ, Burke JF. Stroke Ready: a multi-level program that combines implementation science and community-based participatory research approaches to increase acute stroke treatment: protocol for a stepped wedge trial. Implement Sci. 2019 Mar 7;14(1):24. doi: 10.1186/s13012-019-0869-3.
Clinical trial NCT00355290: Changes in Oral Vitamin K Intake for Optimization of Chronic Oral Anticoagulation: A Randomized Trial
Official title: Changes in Oral Vitamin K Intake for Optimization of Chronic Oral Anticoagulation: A Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Blood Coagulation Disorders
Keywords: Chronic Oral Anticoagulation
Lead sponsor: Hospital de Clinicas de Porto Alegre
Sponsor class: OTHER
Collaborators: name: Conselho Nacional de Desenvolvimento Científico e Tecnológico
First posted: 2006-07-21
Enrollment: 114
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The primary hypothesis of this trial is that changes in oral vitamin K intake, based on simple food registries, may be superior to conventional changes in doses of medications in order to stabilize chronic oral anticoagulation.


Eligibility criteria: Inclusion Criteria:

* Patients with any clinical indication for chronic oral anticoagulation with one INR level out of target, without a clear clinical cause for INR instability (unplanned changes in coumadin medications, other pharmacological interactions, clinical illnesses and laboratory errors).

Exclusion Criteria:

* Clinical evidence of bleeding or thrombosis.
* INR \> 4 or INR \< 1,5.

Primary outcomes:
measure: Percentage of patients on target International Normalized Ratio (prothrombin time) on day 90th after randomization
measure: Stabilization of International Normalized Ratio (prothrombin time) during follow-up (90 days after randomization)
Secondary outcomes:
Other outcomes:
Locations:
city: Porto Alegre
country: Brazil
facility: Hospital de Clínicas de Porto Alegre
state: RS
Study officials:
affiliation: Federal University of Rio Grande do Sul
name: Luis E Rohde, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: de Assis MC, Rabelo ER, Avila CW, Polanczyk CA, Rohde LE. Improved oral anticoagulation after a dietary vitamin k-guided strategy: a randomized controlled trial. Circulation. 2009 Sep 22;120(12):1115-22, 3 p following 1122. doi: 10.1161/CIRCULATIONAHA.109.849208. Epub 2009 Sep 8.
Clinical trial NCT05635890: Effect of Vestibular Rehabilitation on Trunk Kinetic and Kinematic Parameters in Patients With Multiple Sclerosis
Official title: Effect of Vestibular Rehabilitation on Trunk Kinetic and Kinematic Parameters in Patients With Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vestibular Rehabilitation in MS
Keywords: Trunk kinetic and kinematic parameters, Vestibular rehabilitation, Multiple Sclerosis.
Lead sponsor: October 6 University
Sponsor class: OTHER
First posted: 2022-12-02
Enrollment: 30
Sex: ALL
Minimum age (years): 35
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: RCT
Primary purpose: TREATMENT

Brief summary: The Cawthorne Cooksey exercises and conventional program of physical therapy were administered.

Detailed description: • The Cawthorne Cooksey exercises and conventional program of physical therapy were administered.

Eligibility criteria: Inclusion Criteria:

* Aged 35-55 years.
* Ambulatory without assistance.
* Diagnosed with relapsing-remitting MS by a neurologist, with approximately five relapse attacks in the hemiparesis type with a muscular tone of 1 or 1+ depending on the MAS, or modified Ashworth scale.
* All individuals were evaluated by a neurosurgeon to confirm central vertigo using test of Dix Hallpike.
* Degree of MS-related disability based on the enlarged disability status scale, ranging from 2-2.5.

Exclusion Criteria:

* People with musculoskeletal deformities.
* People with inner ear abnormalities.
* People with psychiatric disturbances or seizures.

Primary outcomes:
measure: Isokinetic dynamometer (average power)
timeFrame: 4 weeks
measure: Isokinetic dynamometer (acceleration time)
timeFrame: 4 weeks
measure: Isokinetic dynamometer (deceleration time)
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: El-Sheikh Zayed City
country: Egypt
facility: October 6 University
state: Giza
Study officials:
References:
Clinical trial NCT01555190: Combination Therapy With Myo-inositol and Folic Acid Versus Myo-inositol Alone
Official title: Combination Therapy With Myo-inositol and Folic Acid Versus Myo-inositol Alone: Effects of Six Months Treatment on Clinical, Endocrine and Metabolic Features in Obese Women With Polycystic Ovary Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Polycystic Ovary Syndrome
Hirsutism
Menstrual Irregularity
Keywords: myo-inositol
folic acid
Lead sponsor: Catholic University of the Sacred Heart
Sponsor class: OTHER
First posted: 2012-03-15
Enrollment: 50
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Previous studies have demonstrated that Myo-inositol is capable of restoring spontaneous ovarian activity, and consequently fertility, in most patients with PCOS. The aim of our study is to investigate the role of folic acid conteined in the inositol preparation. The study group included 50 patients, randomly allocated to subgroup A (myo-inositol 1500 gr) and subgroup B (myo-inositol 2000 gr + folic acid 200 mcg). The investigation include menstrual pattern and hirsutism score evaluation, hormonal assays, oral glucose tolerance test, euglycemic hyperinsulinaemic clamp and lipide profile at baseline and after six months of treatment.


Eligibility criteria: Inclusion Criteria:

* women with PCOS diagnosed in accordance with Rotterdam Consensus Conference Criteria 2003
* BMI \> 25 kg/m2
* age 18-35 years

Exclusion Criteria:

* pregnancy
* significant liver or renal impairment
* other hormonal dysfunctions (hypothalamic, pituitary, thyroidal or adrenal causes for the clinical signs)
* neoplasms
* unstable mental illness
* diagnosis of diabetes mellitus or impaired glucose tolerance
* use of drugs able to interfere with gluco-insulinaemic metabolism for at least three months prior entering the study.

Primary outcomes:
measure: number of cycles in six months of therapy
timeFrame: 6 months
Secondary outcomes:
measure: effects on oral glucose tollerance test
timeFrame: six months
measure: effects on hoormonal assay
timeFrame: 6 months
measure: effects oon lipide profile
timeFrame: 6 months
Other outcomes:
Locations:
city: Rome
country: Italy
facility: Catholic University of Sacred Heart
Study officials:
References: