louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02777684: Motivators and Barriers to Physical Activity in Knee Osteoarthritis Patients: a Qualitative Study
Official title: Motivators and Barriers to Physical Activity in Knee Osteoarthritis Patients: a Qualitative Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Knee Osteoarthritis
Keywords: Physical activity
Knee osteoarthritis
Non pharmacological treatment
Qualitative study
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
Collaborators: name: Innovatherm
First posted: 2016-05-19
Enrollment: 27
Sex: ALL
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with symptomatic knee osteoarthritis

Brief summary: This study sought to better identify the motivators and barriers to osteoarthritic patients practising regular physical activity. This is a crucial step towards enabling each health professional to adapt their therapy recommendations, while taking into account the patient's overall lifestyle.

Detailed description: The qualitative research design is well-suited to this type of issue. This choice was justified by need to investigate and understand the actions from the participants' point of view. This exploratory method, conducted in the form of individual interviews and focus groups, enabled us to document the personal experiences, practices, and personal history of each individual

Eligibility criteria: Inclusion Criteria:

* symptomatic knee osteoarthritis

Exclusion Criteria:

-

Primary outcomes:
measure: Motivators and barriers to physical activity in knee osteoarthritis patients activity
timeFrame: During the spa treatment of 18 days
Secondary outcomes:
measure: Definition of physical activity with qualitative method
timeFrame: During the spa treatment of 18 days
measure: Differences between physical activity and sport with qualitative method
timeFrame: During the spa treatment of 18 days
measure: Functional status as assessed by WOMAC
timeFrame: During the spa treatment of 18 days
measure: Level of physical activity with IPAQ short form
timeFrame: During the spa treatment of 18 days
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand
Study officials:
References:
Clinical trial NCT01644084: A Comparison Between 5% Albumin and 6% Hydroxyethyl Starch 130/0.4 in Priming Solution for Cardiopulmonary Bypass and Post-bypass Maintenance Fluid in High-risk Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Keywords: albumin
hydroxyethyl starch 130/0.4
cardiopulmonary bypass
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2012-07-18
Enrollment: 54
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: It is advantageous to use 5% human albumin (HA) in patients undergoing cardiopulmonary bypass (CPB), because preexposure of the synthetic surfaces of the CPB circuit to albumin decreases coagulopathy, platelet aggregation, immune responses. However the use of albumin is limited, because it is expensive and can rarely cause infection.

Hydroxyethyl starch (HES) decreases clot strength and prolong clot formation. A recently developed 6% HES 130/0.4 is known to have fewer effects on hemostasis. However Schramlo AA et al. reported that short time infusion of HES 130/0.4 after cardiac surgery produced impairment in fibrin formation and clot strength in thromboelastometry tracings.

Coagulopathy is directly related to bleeding and massive postoperative bleeding increases the risk of reoperation. Therefore it is important to avoid administration of fluids that can inhibit homeostasis after CPB.

The purpose of this study is to investigate the effect of 6% HES 130/0.4 as a component of priming solution on coagulation compared to 5% HA.


Eligibility criteria: Inclusion Criteria:

* patients who have uncontrolled medical problems, life-threatening cardiac disease, complex cardiac surgery, or emergency operation

Exclusion Criteria:

* patients who had received warfarin, heparin, acetylsalicylic acid, or antiplatelet drug within 5 days before surgery

Primary outcomes:
measure: Effect of 6% hydroxyethyl starch 130/0.4 as a priming solution on coagulation and blood loss following complex heart valve surgery: a comparison with 5% albumin
timeFrame: upto 24hours after cardiopulmonary bypass
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Yonsei Univ. dept. of Anesthesiology and pain medicine
Study officials:
References:
Clinical trial NCT05376384: Ovarian Cyst's Enucleation Spillage Score
Official title: Ovarian Cyst's Enucleation Spillage Score. An Observational Study of Cyst Characteristics for Spillage During Laparoscopic Enucleation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ovarian Cysts
Spillage
Keywords: ovarian cysts
laparoscopy
cyst enucleation
spillage
Lead sponsor: University of Campania Luigi Vanvitelli
Sponsor class: OTHER
First posted: 2022-05-17
Enrollment: 129
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients in the Naples Metropolitan area, southern Italy, where our university hospital is located, suffering from adnexal cystic neoformation for which they need to undergo laparoscopic cystic enucleation surgery. Patients will receive the standard of care regardless of participation in the study, in which they will participate voluntarily and after signing informed consent.

Brief summary: Cystic enucleation is one of the most common conservative surgeries in gynecology; it is commonly performed by a minimally invasive approach such as laparoscopy. A high percentage of these surgeries (6-88 % of cases) are complicated by the cystic rupture with intra-abdominal spillage of its contents (spillage). This occurrence affects the surgical and prognostic outcome by lengthening the time of surgery, increasing the risk of postoperative infection or granulomatous peritonitis, of possible second manifestation of the pathology (example: endometriosis), and in the case of neoformation of a carcinomatous nature by leading to an increase in the stage of disease, exposing patients to a prognostic disadvantage and the need for adjuvant treatments also avoidable. In addition, the previous spillage may be associated with the adherent syndrome with repercussions on patients' morbidity and fertility. For these reasons, it is crucial to optimize the selection of patients who are candidates for cystic enucleation.

The present study aims to evaluate a series of ultrasound, medical history, and surgical-preoperative parameters to develop a predictive score for the risk of spillage during laparoscopic surgery. Prospective Observational Study. The study aims to enroll 156 patients.


Eligibility criteria: Inclusion Criteria:

* Patients \>18 years of age
* Patients undergoing laparoscopic cystic enucleation
* Patients who underwent pelvic ultrasound examination within 30 days prior to surgery
* Patients who signed informed consent for the study
* ECOG performance status \< 2

Exclusion Criteria:

* Pregnancy status
* Patients with cardiological, neurological, or metabolic disorders not treated pharmacologically
* ASA III
* Patients undergoing laparotomy conversion prior to enucleation

Primary outcomes:
measure: Spillage Rate
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Naples
country: Italy
facility: Università degli Studi della Campania Luigi Vanvitelli
Study officials:
References:
Clinical trial NCT01324284: Comparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation for Colonoscopy
Official title: Comparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation to Enhance the Colonoscopy Preparation Quality in an Indian Tertiary Care Center.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Colorectal Carcinoma
Keywords: Lubiprostone
Bowel preparation regime
Lead sponsor: Asian Institute of Gastroenterology, India
Sponsor class: OTHER
First posted: 2011-03-29
Enrollment: 442
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Lubiprostone as an adjunct to the standard bowel preparation regime the quality of bowel preparation can be improved for a good colonoscopic examination without missing lesions and complications.

Detailed description: Objectives:

1. Primary:

   * Same day Low volume PEG with placebo (Arm 1) versus same day low volume PEG with Lubiprostone (Arm 2)
   * Waiting time for colonoscopic procedure and quality of bowel preparation
2. Secondary:

   * Quality of bowel preparation without Dietary restriction (Modified bowel preparation regime without Fiber diet restrictions)

Eligibility criteria: Inclusion Criteria:

1. All adult patient referred for colonoscopy to AIG
2. Age 18 - 75 years old

Exclusion Criteria:

1. Acute GI bleeding.
2. Patient of bowel preparation regime other than excepted for the study.
3. Renal insufficiency.
4. Dementia.
5. Symptomatic heart failure.
6. Recent Myocardial Infarction.
7. Patients with ileus.
8. Suspected bowel obstruction.
9. Prior alimentary tract surgery.
10. Significant gastroparesis.
11. Gastric outlet obstruction.
12. Toxic colitis or megacolon.
13. Pregnant or lactating patients.

Primary outcomes:
measure: Quality of bowel preparation in Same day Low volume PEG with placebo versus same day low volume PEG with Lubiprostone
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Asian Institute of Gastroenterolgy India
name: Nageshwar D Reddy, MD. DM
role: STUDY_DIRECTOR
affiliation: Asian Institute of Gastroenterology, India
name: Rupa Banerjee, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Asian Institute of Gastroenterology, India
name: Saravanan Arjunan, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: AIG Hyderabad india
name: Manu Tandan, MD DM
role: PRINCIPAL_INVESTIGATOR
References:
citation: Banerjee R, Chaudhari H, Shah N, Saravanan A, Tandan M, Reddy DN. Addition of Lubiprostone to polyethylene glycol(PEG) enhances the quality & efficacy of colonoscopy preparation: a randomized, double-blind, placebo controlled trial. BMC Gastroenterol. 2016 Oct 13;16(1):133. doi: 10.1186/s12876-016-0542-0.
Clinical trial NCT05273684: High-intensity Interval Training in Patients With COPD: a Fidelity and Tolerability Study
Official title: High-intensity Interval Training in Patients With COPD: a Fidelity and Tolerability Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Keywords: HIIT
COPD
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
First posted: 2022-03-10
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Although high-intensity training (HIIT) is widely used in the rehabilitation of patients with chronic obstructive pulmonary disease (COPD), the optimal duration of intervals in terms of patient tolerability and fidelity is unknown.Thus, we will examine the fidelity and tolerability of the two most commonly used HIIT protocols, the classical so-called 4x4min vs. 10x1min in patients with moderate to severe COPD.

Detailed description: 12 patients with severe to moderate COPD will be included in the study, where two different HIIT interventions will be compared with regards to fidelity and tolerability. Baseline measurements will be performed to assess fitness and cardiopulmonary health status for the included patients. The baseline measurements include a medical health interview and examination (blood pressure, heart rate, ECG), a maximal oxygen consumption (VO2max) test, lung function testing (dynamic spirometry, whole body plethysmography, diffusing capacity), and an assessment of body composition. The following two visits consist of two different HIIT protocols.

Each training session is evaluated by Borg Scale (5) and the Likert Scale (6), as well as time spent in with a heart rate above 85% of maximum. Each HIIT session is separated by at least a 3-day wash-out period.

Eligibility criteria: Inclusion Criteria:

* Men and women
* 18-80 years
* Moderate to severe COPD(GOLD stage II to III)

Exclusion Criteria:

* Known ischaemic heart disease
* Known heart failure
* Previous or current coronavirus disease 2019 (COVID-19)
* Dementia or other severe neurological disease
* Known vascular
* Symptoms of disease within 2 weeks prior to the study
* Pregnancy

Primary outcomes:
measure: Exercise feasibility: Relative dose intensity (RDI) of exercise
timeFrame: 1 week
measure: Exercise feasibility: Exercise sessions requiring dose modifications
timeFrame: 1 week
measure: Exercise tolerability: Subjective rating of the exercise session
timeFrame: 1 week
measure: Exercise feasibility: Exercise sessions attendance rate
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Rigshospitalet
Study officials:
affiliation: Rigshospitalet, Denmark
name: Ronan Berg, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT07018284: Postoperative Pain Evaluation After Obturation With Different Sealers
Official title: Assessment of Postoperative Pain Incidence in Teeth Affected by Pulpitis, Necrosis, or Previously Treated, Following Obturation With Bioceramic or Resin-based Sealers
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Periapical Periodontitis
Pulpitis
Necorsis
Keywords: Bioceramic sealers
Resin-based sealers
Endodontics
Lead sponsor: University of Siena
Sponsor class: OTHER
Collaborators: name: Universidad Rey Juan Carlos
First posted: 2025-06-12
Enrollment: 270
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to evaluate the incidence and intensity of postoperative pain in patients undergoing root canal treatment on teeth diagnosed with pulpitis, pulp necrosis, or with previous endodontic treatment. Teeth will be obturated using either bioceramic or resin-based sealers. The primary objective is to determine whether the type of sealer significantly influences the level of postoperative pain as reported by patients. Pain intensity will be assessed using the Visual Analogue Scale (VAS) at three time points: immediately after treatment, 24 hours, and 72 hours postoperatively. The findings are expected to provide clinical insight into which obturation material may be more effective in minimizing postoperative discomfort.


Eligibility criteria: Inclusion Criteria:

Patients aged 18 years and older. Teeth with a diagnosis of pulpal necrosis or irreversible pulpitis. Informed consent provided for data usage.

Exclusion Criteria:

* Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression).
* Asymptomatic presentation
* Teeth with root fractures, resorption, or open apices.
* Incomplete clinical or radiographic records.
* Cases with poor-quality radiographs or lack of standardization for evaluation

Primary outcomes:
measure: Radiographic Success Based on Periapical Index (PAI) Criteria
timeFrame: Minimum 6 months after root canal treatment
Secondary outcomes:
measure: Clinical Success Based on Absence of Symptoms
timeFrame: Minimum 6 months after treatment
measure: Radiographic Success Based on CBCT Evaluation
timeFrame: Minimum 6 months after treatment
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: Universidad Rey Juan Carlos , Madrid, Spain 28922
Study officials:
affiliation: Universidad Rey Juan Carlos , Madrid, Spain 28922
name: José Aranguren, MsC
role: STUDY_DIRECTOR
affiliation: University of Siena
name: Simone Grandini, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05729984: Paula Method Versus Chewing Gum for Postoperative Recovery After Caesarean Section
Official title: Comparing Effectiveness of Paula Method Versus Chewing Gum for Postoperative Recovery of Gastrointestinal Function in Patients After Elective Caesarean Section
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cesarean Delivery Affecting Fetus
Post Operative Bowel Function
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2023-02-15
Enrollment: 90
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to compare the effectiveness of gum chewing vs Paula exercises in patients after cesarean delivery. The main question it aims to answer is: does the Paula method hasten the time to recovery of bowel function compared to gum chewing after cesarean delivery.

Participants will be asked to either chew gum or to do Paula exercises. The time to restoration of bowel function after the surgery will be measured.


Eligibility criteria: Inclusion Criteria:

* Women after an elective caesarean delivery
* Age 18+
* Ability to read and write in Hebrew

Exclusion Criteria:

* Diagnosis of chronic gastrointestinal diseases
* Inability to chew gum
* Use of laxatives.

Primary outcomes:
measure: Time to first flatus or bowel movements
timeFrame: Up to one week from delivery
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
Study officials:
References:
Clinical trial NCT02548884: Pancreatic Sphincterotomy Versus Double Wire Technique in Difficult Cannulation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Endoscopic Retrograde Cholangiopancreatography
Lead sponsor: Helsinki University Central Hospital
Sponsor class: OTHER
Collaborators: name: Turku University Hospital
name: Oulu University Hospital
First posted: 2015-09-14
Enrollment: 1190
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to compare two different techniques (pancreatic sphincterotomy (PS) and double wire technique (DGW)) regarding the risk of post-ERCP pancreatitis (PEP) and the success of cannulation in difficult cannulation. For the study, the difficult cannulation is de-fined as situation when the common bile duct has not been cannulated in five minutes, after five attempts or after two pancreatic guide wire passages or when any of those limits is exceeded. The two techniques, the PS and the DGW, will be compared in random fashion. The primary end-point is the risk of PEP .


Eligibility criteria: Inclusion Criteria:

* Naive papilla, ERCP indication common bile duct cannulation

Exclusion Criteria:

* No consent to the study
* Ongoing pancreatitis

Primary outcomes:
measure: Post ERCP pancreatitis defined by ESGE guidelines published 2014
timeFrame: 48 hours
Secondary outcomes:
measure: Biliary cannulation success within 15 minutes after randomization
timeFrame: 15 minutes
measure: Biliary cannulation success, total number
timeFrame: 2 hours
Other outcomes:
Locations:
city: Helsinki
country: Finland
facility: Helsinki University Hospital
Study officials:
References:
citation: Halttunen J, Meisner S, Aabakken L, Arnelo U, Gronroos J, Hauge T, Kleveland PM, Nordblad Schmidt P, Saarela A, Swahn F, Toth E, Mustonen H, Lohr JM. Difficult cannulation as defined by a prospective study of the Scandinavian Association for Digestive Endoscopy (SADE) in 907 ERCPs. Scand J Gastroenterol. 2014 Jun;49(6):752-8. doi: 10.3109/00365521.2014.894120. Epub 2014 Mar 14.
Clinical trial NCT04779502: The Efficacy of Oregano Essential Oil in Reducing Oral Halitosis
Official title: The Efficacy of Oregano Essential Oil in Reducing Oral Halitosis :A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Halitosis
Keywords: oral halitosis
oregano essential oil
mouthwash
Lead sponsor: University of Baghdad
Sponsor class: OTHER
First posted: 2021-03-03
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Maximum age (years): 23
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: the efficacy of commercially available oregano essential oil mouthwash in the reduction of oral halitosis was compared to chlorhexidine and distilled water and the results showed significant reduction of organoleptic tongue and floss scores and BANA test scores compared to placebo

Detailed description: the results showed that oregawash showed a comparable effect to chx in reducing oral halitosis

Eligibility criteria: Inclusion Criteria:

1. Organoleptic score was \>2 at baseline.
2. Participants between 18-23 years of age.
3. The subjects had no systemic disease and were not taking antibiotics or receiving other antimicrobial therapy.
4. The subjects did not receive the same time treatment for their halitosis.

Exclusion Criteria:

1. Smokers, alcoholics and drug addicts.
2. Patients with periodontitis or pocket depth \>6 mm.
3. Patients taking drugs which induced xerostomia.
4. Subjects consuming spicy food: garlic or onions two days before examination.
5. Patients with orthodontic appliances or removable dentures.
6. pregnancy

Primary outcomes:
measure: organoleptic tongue and floss scores
timeFrame: 9 month
Secondary outcomes:
measure: BANA test
timeFrame: 9 month
Other outcomes:
Locations:
city: Baghdad
country: Iraq
facility: Univeristy of Baghdad
state: Rasafa
Study officials:
affiliation: univeristy of baghdad
name: mohamed s albana, director
role: PRINCIPAL_INVESTIGATOR
References: