Clinical trial NCT05511402: Effect of Aerobic Training on Oxidative Stress Markers in Patients With Parkinson's Disease
Official title: The Effect of Aerobic Training on Total Antioxidant Status, Total Oxidant Status, Glutathione, Oxidative Glutathione and Zonulin Levels in Patients With Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Parkinson Disease
Keywords: Parkinson Disease
exercise
total antioxidant status
total oxidant status
glutathione
oxidative glutathione
zonulin
Lead sponsor: Saglik Bilimleri Universitesi
Sponsor class: OTHER
Collaborators: name: Gazi University
First posted: 2022-08-23
Enrollment: 28
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Parkinson's disease is a chronic, neurodegenerative disorder characterized with the loss of dopamine-producing neurons. This loss is likely to be related with several environmental and genetic factors. One of the most important factor that is responsible for the initation and progression of the disease is oxidative stress. Exercise training, especially aerobic training, can change the levels of oxidative markers because exercise can lead to decrease oxidative stress in patients with Parkinson's disease. Therefore, this study aims to investigate (1) the effect of aerobic training on total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels, (2) the relationship between the change of motor symptoms and disease severity and the change of total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels.


Eligibility criteria: Inclusion Criteria:

* at least 40years of age
* diagnosed with Parkinson's Disease
* Hoehn and Yahr stage of 1 and 3

Exclusion Criteria:

* any other neurologic disorders,
* any cardiovascular, orthopedic, vestibular or rheumatic conditions that impact exercise training
* visual, auditory, and perception problems.

Primary outcomes:
measure: Total antioxidant status
timeFrame: 10 minutes
measure: Total oxidant status
timeFrame: 10 minutes
measure: Glutathione
timeFrame: 10 minutes
measure: Oxidative glutathione
timeFrame: 10 minutes
measure: Zonulin
timeFrame: 10 minutes
Secondary outcomes:
measure: Movement Disorders Society Unified Parkinson's Disease Rating Scale
timeFrame: 15 minutes
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Saglik Bilimleri Universitesi
Study officials:
affiliation: Gazi University
name: Ayse Bora Tokcaer, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References:
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