Clinical trial NCT06983379: Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders
Official title: Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders: An Original Clinical Investigation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Autism Spectrum Disorders
Keywords: oxidative stress
Vitamin D
Autism Spectrum Disorders
Lead sponsor: Mardin Artuklu University
Sponsor class: OTHER
Collaborators: name: Alanya Alaaddin Keykubat University
First posted: 2025-05-21
Enrollment: 68
Sex: ALL
Minimum age (years): 0
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study included children who visited the Child and Adolescent Psychiatry and Adolescent Pediatric Gastroenterology outpatient clinics.

Brief summary: Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders

Detailed description: Introduction:

The etiology of Autism Spectrum Disorder (ASD) is thought to be complex. Increasing evidence in the literature shows that oxidative stress plays a role in the development and prognosis of autism. In our study, investigators aimed to investigate whether thiol disulfide balance, which is a new marker of oxidative stress, is different from that in normal children with autism spectrum disorder.

Methods A total of 68 children, 38 with autism spectrum disorder and 30 healthy controls, were included in the study. Dynamic thiol balance, total oxidant status, total antioxidant status, ischemia-modified albumin, paraoxonase 1, and arylesterase activities were measured using colorimetric methods. Routine biochemical parameters were obtained from their files and evaluated.

Eligibility criteria: Control group inclusion criteria:

* Healthy children who applied to the pediatric clinic for routine examination

Control group exclusion criteria:

* Children who have any chronic medical diseases or psychiatric disorders
* Children who have a family history of chronic medical diseases or psychiatric disorders

Autism spectrum disorder group inclusion criteria:

* Children with autism spectrum disorder (Diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR))

Autism spectrum disorder group exclusion criteria:

* Children who have a family history of chronic medical diseases or psychiatric disorders

Primary outcomes:
measure: Oxidative stress markers
timeFrame: From January 2020 to Jun 2021
measure: Oxidative stress markers
timeFrame: From January 2020 to Jun 2021
measure: Oxidative stress markers
timeFrame: From January 2020 to Jun 2021
measure: Oxidative stress markers
timeFrame: From January 2020 to Jun 2021
measure: Oxidative stress markers
timeFrame: From January 2020 to Jun 2021
measure: Oxidative stress markers
timeFrame: From January 2020 to Jun 2021
measure: Oxidative stress markers
timeFrame: From January 2020 to Jun 2021
measure: Oxidative stress markers
timeFrame: From January 2020 to Jun 2021
measure: Oxidative stress markers
timeFrame: From January 2020 to Jun 2021
Secondary outcomes:
Other outcomes:
Locations:
city: Antalya
country: Turkey
facility: Alanya Training and Research Hospital
Study officials:
References: