Clinical trial NCT05623579: Education on BDNF on Pain Levels
Official title: Effect of Therapeutic Education on Pain Intensity and BDNF Levels in Patients With Chronic Pain
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Chronic Pain
Musculoskeletal Pain
Keywords: BDNF
Pain Neuroscience Education
Exercise
Lead sponsor: Universidad Autonoma de Madrid
Sponsor class: OTHER
Collaborators: name: Universidad Rey Juan Carlos
First posted: 2022-11-21
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The promotion of neuroplasticity in conjunction with strategies for restructuring maladaptive cognitions that largely cause the activation of neural networks that contribute to the perpetuation of pain is therefore a fundamental neurophysiological principle for establishing a neurophysiological basis for pain.

perpetuation of pain, is therefore a fundamental neurophysiological principle for establishing physiotherapy therapeutic to establish therapeutic strategies from physiotherapy that contribute to improve the quality of life of patients with chronic pain. patients with chronic pain.

Based on the theory that neurotrophic factors such as BDNF play a fundamental role in the initiation and or maintenance of hyperexcitability of central neurons in pain, we consider that the levels of this neurotrophic factor, such as BDNF, may have an important role in the perpetuation of pain.

that the levels of this neurotrophic factor may be modified by the application of a therapeutic education protocol, favoring therapeutic education protocol, favoring a reduction in pain intensity.


Eligibility criteria: Inclusion Criteria:

* males and females aged 18 to 65 years with musculoskeletal pain for a minimum of 3 months
* patients recruited by information pamphlets from the university clinic of the Rey Juan Carlos University, and CSEU La Salle
* not having received physiotherapy treatment for this same process in the last 3 months.
* ability to perform all the clinical tests and to understand the study process, as well as to obtain informed consent.

Exclusion Criteria:

- Systemic, neurological, oncological or inflammatory diseases; psychiatric pathologies, pregnancy, type II diabetes.

Primary outcomes:
measure: Pain Intensity
timeFrame: 36 weeks
Secondary outcomes:
measure: BDNF level
timeFrame: 36 weeks
measure: Anxiety and Depression (HADS)
timeFrame: 36 weeks
measure: Quality of life (EQ-5D)
timeFrame: 36 weeks
measure: Pain Catastrophism (PCS)
timeFrame: 36 weeks
measure: Pain Severity Level (GCPS-R)
timeFrame: 36 weeks
measure: Oxygen Saturation (SpO2)
timeFrame: 36 weeks
measure: Heart rate (HR)
timeFrame: 36 weeks
Other outcomes:
Locations:
city: Alcorcón
country: Spain
facility: Clínica URJC
state: Madrid
city: Madrid
country: Spain
facility: IRF La Salle
Study officials:
References:
citation: Mills SEE, Nicolson KP, Smith BH. Chronic pain: a review of its epidemiology and associated factors in population-based studies. Br J Anaesth. 2019 Aug;123(2):e273-e283. doi: 10.1016/j.bja.2019.03.023. Epub 2019 May 10.
citation: Andias R, Neto M, Silva AG. The effects of pain neuroscience education and exercise on pain, muscle endurance, catastrophizing and anxiety in adolescents with chronic idiopathic neck pain: a school-based pilot, randomized and controlled study. Physiother Theory Pract. 2018 Sep;34(9):682-691. doi: 10.1080/09593985.2018.1423590. Epub 2018 Jan 10.