louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03061695: Application of Digitized Respiratory Sounds for Confirmation of the Position of the Balloon of Endobronchial Blockers
Official title: The Application of the Spectral Analysis and Characteristic Parameters of Digitized Respiratory Sounds in the Confirmation of the Position of the Balloon of Endobronchial Blockers - an Observational Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Respiratory Sounds
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2017-02-23
Enrollment: 30
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Thoracic patients scheduled for thoracic surgery and lung isolation during the surgery

Brief summary: This observation study is to evaluate the application of the spectral analysis and characteristic parameters of digitized respiratory sounds in the confirmation of the position of the balloon of endobronchial blockers

Detailed description: This is an observational study. We will recruit 30 patients who are scheduled for thoracic surgery under general anesthesia with tracheal intubation and need endobronchial blocker for unilateral lung ventilation during the operation. The standard procedures for confirming the position of the balloon of the endobronchial blocker, including the stethoscopic inspection and the fiberoptic examination, will be performed as routine practice. But in our study, besides the above routine practice, a microphone will be connected to the distal end of the stethoscope (the microphone will not contact directly with the patients) during the checking procedure to record the breathing sound into a digital computer as electronic files. These breathing sound files will be analyzed in a later time with spectral transformation and the characteristics are extracted. These digital signal processing results will be compared with the results of fibroptic exmination and the stethoscopic auscultation in the correct rate of diagnosing the position of the endobronchial balloon. The aim of this study is to examine the usefulness of the spectral parameters of the digitalized breathing sound in confirming the position of the endobronchial blocker balloon.

Eligibility criteria: Inclusion Criteria:

* Thoracic disease patients who are scheduled for thoracic surgery and lung isolation requiring endobronchial blocker placement during the surgery
* Adult patients (no younger than 20 years old)

Exclusion Criteria:

* Patients with significant thoracic diseases which result in abnormal respiratory sounds

Primary outcomes:
measure: Position of the endobronchial blocker
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: National Taiwan University Hospital
name: Hui-Hsun Huang, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06597695: A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults with Depression
Official title: A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults with Depression
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: EARLY_PHASE1
Conditions: Depression
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This is a pilot clinical trial to assess the feasibility, safety, and preliminary efficacy of ketamine-assisted group therapy for Spanish-speaking adults with depression


Eligibility criteria: Inclusion Criteria:

1. Self-identifying Latinx, Spanish-speaking
2. Adults 18-64 years
3. Meet DSM-5 criteria for major depressive disorder as evaluated by study clinician
4. Participants must have an MGB psychiatrist and primary care provider.

Exclusion Criteria:

1. History of primary psychotic disorder, by history
2. History Bipolar I disorder, by history
3. Unstable complex PTSD, as assessed by study clinician
4. History of dissociative identity disorder
5. History of neurocognitive disorder
6. History of severe and/or recent substance use disorder, by history and as assessed by study clinician after clinical evaluation and interview
7. Uncontrolled hypertension, tachycardia, or unstable cardiopulmonary disease, by history a. Blood pressure on initial screen must be \<140/90 mmHg.
8. History of aortic dissection
9. History of myocardial infarction
10. History of aneurysm
11. History of hepatic impairment.
12. History of epilepsy
13. History of prior hypersensitivity to ketamine
14. Body Mass Index greater than 35
15. Body Mass Index less than 18.5
16. Are pregnant, breastfeeding, or planning to become pregnant within 12 weeks of treatment completion
17. Enrolled in other clinical trial for the treatment of depression or other behavioral health diagnosis
18. Inability to provide consent.

Primary outcomes:
measure: Evaluate feasibility of a culturally adapted group-based ketamine intervention for Spanish- speaking adults with depression in a community setting
timeFrame: 1 week post-intervention
measure: To assess the safety of a ketamine-assisted group psychotherapy intervention for Spanish-speaking participants with depression in a community setting.
timeFrame: 1 week post-intervention
Secondary outcomes:
measure: Investigate the preliminary efficacy of the group-based ketamine intervention on psychiatric symptoms, wellbeing, and health behaviors among Spanish-speaking participants with depression.
timeFrame: 1 and 12 weeks post-intervention
Other outcomes:
Locations:
Study officials:
affiliation: Mass. General Hospital
name: Juliana Zambrano, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT02904395: Feasability and Interest of Screening for Infantile Pompe's Diseases at Birth
Official title: Feasability and Interest of Screening for Infantile Pompe's Diseases at Birth
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pompe's Disease
Lead sponsor: Centre Hospitalier de Cayenne
Sponsor class: OTHER
First posted: 2016-09-19
Enrollment: 3413
Sex: ALL
Maximum age (years): 2
Standard ages: CHILD
Accepts healthy volunteers: no
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: newborns

Brief summary: Given the 100 fold increase of the incidence of Pompe's disease in Western French Guiana, the objective of the present study is to implement systematic screening in newborns in French Guiana in order to start treatment before the muscular and cardiac symptoms appear.


Eligibility criteria: Inclusion Criteria:

* newborn

Exclusion Criteria:

* parent refusal

Primary outcomes:
measure: acid maltase activity
timeFrame: At birth
measure: Signature mutation for pompe's disease
timeFrame: At birth
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03195595: Minimal Invasive Mitral Valve Replacement Versus Conventional Median Sternotomy Approach
Official title: Minimal Invasive Mitral Valve Replacement Versus Conventional Median Sternotomy Approach
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Mitral Valve Disease
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-06-22
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: It includes groups of population above age of 18 with symptomatic mitral valve disease indicated for valve surgery

Brief summary: This is retrospective study that will be done in Cardiothoracic surgery department in Assuit university hospitals for one year duration aiming to compare minimal invasive technique to conventional median sternotomy for mitral valve surgery regarding early postoperative outcomes and pain

Detailed description: This is retrospective study that will be done in Cardiothoracic surgery department in Assuit university hospitals for one year duration and the study tools will be:

Part I (Demographic data):

* Age, Gender, Weight, Height ,Smoke history

Part II (Preoperative data):

* Medical history, Clinical assessment, Preoperative investigation

Part III (Intraoperative data):

* Surgical time, and Ischemic time

Part IV (Postoperative data):

* Early ambulation, ICU stay, length of ventilation, using of analgesic drugs, post op bleeding, deaths

Eligibility criteria: Inclusion Criteria:

* Symptomatic patients with mitral valve disease indicated for valve surgery

Exclusion Criteria:

* Double valve disease or other valve disease
* Mitral or aortic valve disease associated with ischemic heart disease
* Mitral or aortic valve disease associated with congenital heart disease
* Patients subjected to prior heart surgery

Primary outcomes:
measure: Evaluating of postoperative pain by using numerical rating scales (NRS)
timeFrame: one year
Secondary outcomes:
measure: Evaluating early postoperative outcome
timeFrame: one year
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University Hospitals
Study officials:
affiliation: Assuit university hospital
name: mohamed A nady, lecturer
role: STUDY_DIRECTOR
References:
Clinical trial NCT00530595: Effects of Angiotensin Receptor Antagonist on Prohibiting Cardiovascular Events on Hemodialysis Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiovascular Disease
Keywords: hemodialysis
Lead sponsor: Saitama Medical University
Sponsor class: OTHER
First posted: 2007-09-17
Sex: ALL
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Cardiovascular disease is a leading cause of mortality in patients on hemodialysis therapy (HD), accounting for 30 to 50% of all death. Although angiotensin receptor blockers (ARBs) are effective for patients with diabetes and chronic kidney disease in reducing or preventing cardiovascular diseases, there has been no decisive study that demonstrated treatment with ARBs is effective in patients on HD.


Eligibility criteria: Inclusion Criteria:

* 30 to 80 years of age
* Receiving hemodialysis at least 12 months and less than 5 years
* Pre-dialysis systolic blood pressure was more than 160 mmHg, or more than 150 mmHg if the patients received antihypertensive agents.

Exclusion Criteria:

* Use of angiotensin receptor blocker or angiotensin converting enzyme inhibitor

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Department of Nephrology, Saitama Medical University
name: Hiromichi Suzuki, MD, PhD
role: STUDY_DIRECTOR
References:
citation: Suzuki H, Kanno Y, Sugahara S, Ikeda N, Shoda J, Takenaka T, Inoue T, Araki R. Effect of angiotensin receptor blockers on cardiovascular events in patients undergoing hemodialysis: an open-label randomized controlled trial. Am J Kidney Dis. 2008 Sep;52(3):501-6. doi: 10.1053/j.ajkd.2008.04.031. Epub 2008 Jul 24.
Clinical trial NCT06543095: Rib Removal and Pain in Partial Nephrectomy
Official title: Rib Removal in Retroperitoneal Open Partial Nephrectomy: Not As Painful As It Seems
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pain
Partial Nephrectomy
Kidney Cancer
Keywords: Rib Removal
Partial nephrectomy
pain
renal cancer
Lead sponsor: TC Erciyes University
Sponsor class: OTHER
First posted: 2024-08-07
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who underwent open partial nephrectomy with flank incision between July 2022 and October 2023 in our clinic.

Brief summary: In this study, the effect of rib removal on postoperative pain in kidney cancer patients undergoing retroperitoneal open partial nephrectomy with flank incision was investigated. For this purpose, VAS score surveys were prepared for patients who underwent partial nephrectomy surgery in the early and late postoperative periods.


Eligibility criteria: Inclusion Criteria:

* Patients aged over 18 years who underwent open renal surgery due to kidney cancer were included in the study.

Exclusion Criteria:

* Patients with a preoperative (one day before surgery) VAS score greater than 0,
* Those with additional known diseases that could cause pain (herniated disc, urinary stone disease, inflammatory bowel diseases, other intra-abdominal pathologies),
* Intraoperative complications that could cause postoperative pain, metastasis, positive surgical margins or peri-renal invasion,
* Those who underwent laparoscopic surgery or those who converted to open surgery after laparoscopic surgery,
* Patients that regularly used painkillers for other reasons,
* Patients whose ribs other than the 11th rib were removed were excluded from the study.

Primary outcomes:
measure: Pain level
timeFrame: days 0, 1, and 3 and week 3
Secondary outcomes:
measure: Complications
timeFrame: Postoperative 7 days
Other outcomes:
Locations:
city: Kayseri
country: Turkey
facility: Erciyes University
Study officials:
References:
Clinical trial NCT00880295: Patient Outcomes With Endoscopic Versus Open Carpal Tunnel Release
Official title: Endoscopic vs Open Carpal Tunnel Release: Comparison of Patient Satisfaction, Outcomes, and Complications
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Carpal Tunnel Syndrome
Lead sponsor: Penn State University
Sponsor class: OTHER
First posted: 2009-04-13
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Although some surgeons prefer one technique rather than the other, both endoscopic and open carpal tunnel release procedures are accepted as standard of care surgeries to relieve carpal tunnel syndrome. The investigator's research is designed to evaluate the significant difference in patient satisfaction between endoscopically-released wrists and open-released wrists. The goal of the study is to compare the two techniques using the following criteria:

1. Primary outcome: patient satisfaction via surveys used in prior publications
2. Secondary outcome: length of time to return to work
3. Secondary outcome: clinical data for recovery from carpal tunnel syndrome including a thorough physical exam and EMG's
4. Secondary outcome: complication rates


Eligibility criteria: Inclusion Criteria:

1. Patients between the ages of 18 and 75
2. Documented clinical and electromyography (EMG) proven carpal tunnel syndrome

Exclusion Criteria:

1. Recurrent carpal tunnel syndrome
2. Inflammatory arthropathy
3. Peripheral neuropathy
4. Diabetes
5. \< 18 or \> 75 years old
6. Pregnant at the time of enrollment

Primary outcomes:
measure: Primary outcome: patient satisfaction via surveys used in prior publications
timeFrame: 24 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Hershey
country: United States
facility: Penn State College of Medicine, Penn State Milton S. Hershey Medical Center
state: Pennsylvania
Study officials:
affiliation: Penn State College of Medicine, Penn State Milton S. Hershey Medical Center
name: Stephen Nogan, B.S.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04919395: Preliminary Evaluation of a "Clip" Device for Contraceptive Implant Removal
Official title: Evaluation of a "Clip" Device Added to the Current Standard Removal of Contraceptive Implant to Improve Stability of the Implant, Shorten Removal Time, and Increase the Ease of Removal
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Contraception
Keywords: Nexplanon removal
Medical device
Lead sponsor: University of Michigan
Sponsor class: OTHER
Collaborators: name: VentureWell
First posted: 2021-06-09
Enrollment: 4
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 49
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Information regarding the planned intervention study model was removed, as the trial did not meet its recruitment goals.
Primary purpose: TREATMENT

Brief summary: This trial is being completed to understand how the study "Clip" device works when assisting clinicians with Nexplanon removals. The study device clips to the skin to hold the implant still and raise the tip of the implant during removal. The study device may improve the process for removing under arm implants by decreasing procedure time and improving the ease and safety of the procedure.

The results from this study will help the researchers understand whether the study device has the potential to simplify the removal procedure and make this form of birth control safer for patients.


Eligibility criteria: Inclusion Criteria:

* Currently using Nexplanon and requesting removal
* Qualifies for outpatient removal
* Ability to understand and sign informed consent

Exclusion Criteria:

* Pregnancy
* Any rashes or skin conditions around the insertion site
* Known allergy to lidocaine
* Known allergy to biocompatible plastics or stainless steel

Primary outcomes:
measure: Time to remove the contraceptive implant device
timeFrame: During the intervention/procedure/surgery
measure: Length of incision used for the removal of the single rod contraceptive implant device
timeFrame: During the intervention/procedure/surgery
Secondary outcomes:
measure: Pain based on the Wong-Baker FACES Pain rating scale from the removal of single rod contraceptive
timeFrame: During the intervention/procedure/surgery
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
Study officials:
affiliation: University of Michigan
name: Carrie Bell, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00555295: Laparoscopic Colorectal Surgery For Cancer- Long Term Survival
Official title: Survival After Laparoscopic Colorectal Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Colon Cancer
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2007-11-08
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Colon Cancer

Brief summary: The purpose of this study is to determine the survival after laparoscopic colectomies due to carcinoma.

Detailed description: Laparoscopic procedures for Colorectal Carcinoma are taking place in the modern era of surgery, It was not proven yet to show pure advantage over the open colectomies.

These Procedures require highly skilled stuff with long learning curve, Financial sources,Increasing operation length.

This retrospective study intends to show that the outcome of the overall survival is better in Laparoscopic patients.

All data about patients who had laparoscopic colectomies due to carcinoma in Surgery A department in Souraski Medical Center was recorded prospectively since the operation day till discharge.

The retrospective follow up will be collected from the outpatient clinic, the Oncology clinic and by questionnare to the patients.

We wish to show that patients who were operated laparoscopy have better survival, better quality of life postoperatively.

Eligibility criteria: Inclusion Criteria:

* Adenocarcinoma of colon

Exclusion Criteria:

* Non curative operation
* Non cancerous subjects

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Tel Aviv Souraski Medical Center
name: Shmuel Avital, md
role: STUDY_CHAIR
affiliation: Tel Aviv Souraski Medical Center
name: Smadar Nir, md
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03436095: The Clinical Study of Bundle Measures to Improve the Success Rate of Patients With Difficult Ventilator Weaning
Official title: The Clinical Study of Bundle Measures to Improve the Success Rate of Patients With Difficult Ventilator Weaning
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Weaning Failure
Keywords: Bundle
difficult ventilator weaning
Lead sponsor: Shenzhen Second People's Hospital
Sponsor class: OTHER
First posted: 2018-02-19
Enrollment: 90
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: difficult-weaning patients with Non neurogenic disease in ICU.

Brief summary: Based on nutritional support, Cardiopulmonary rehabilitation and Levosimendan Bundle measures, and making beside checklist of patients with difficult ventilator weaning; Implementation of nutritional risk, respiratory function, and cardiac function assessment prior to weaning; Regulate the procedure to solve the problem of difficult-weaning patients with Non neurogenic disease in ICU. Thereby,improve the success rate of weaning patients, so as to shorten the ICU hospitalization time, reduce medical costs, reduce the complications of mechanical ventilation, improve the patient's quality of life.

Detailed description: Older than 16 years of age, ventilator therapy more than 1 weeks, Ventilator parameters meet the standard of ventilator removal, repeated more than 3 times SBT not successful, or within a short period of time within a week of successful weaning, no other new incentives to need ventilator support again, and delayed weaning from ventilator more than 1 months.

Eligibility criteria: Inclusion Criteria:

Older than 16 years of age, ventilator therapy more than 1 weeks,ventilator parameters up to Weaning standard, repeated more than 3 times Spontaneous Breathing Test(SBT) not successful, or within a short period of time within a week of successful weaning, no other new incentives to re machine induced delayed more than 1 months or more offline.

-

Exclusion Criteria:

Mechanical ventilation patients who are clearly defined as neurological disorders or advanced tumor wasting diseases, as well as those without informed consent.

-

Primary outcomes:
measure: Bundle measures can solve the problem of difficult-weaning patients with Non neurogenic disease in ICU.
timeFrame: From June 1st 2017 to June 30 2020
Secondary outcomes:
Other outcomes:
Locations:
city: Shenzhen
country: China
facility: Shenzhen Second People's Hospital
state: Guangdong
Study officials:
affiliation: study principal investigator Shenzhen Second Hospital
name: Meng Xinke
role: STUDY_DIRECTOR
References: