louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04596423: Sief_Twist Sign a Novel View in Fetal Echocardiography
Official title: Sief_Twist Sign a Novel View in Fetal Echocardiography
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fetal Echocardiography
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-10-22
Enrollment: 600
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: observational study conducted at academic perinatal center that investigates Sief_Twest sign as novel sign in fetal heart examination in comparison with classic standard views Patients who give written consent to participate in the study undergo a uniform antenatal assessment protocol that includes basic obstetrics ultrasound examination , fetal anatomy scan \& fetal echocardiography .

Brief summary: To describe Sief_twist sign as a novel sign in fetal echocardiography as a new ,easy , time effective view in fetal heart examination .


Eligibility criteria: Inclusion Criteria:

1. Singleton fetus .
2. gestational age 14-37 weeks.
3. no maternal medical disorder .
4. no morbed obisity.

Exclusion Criteria:

1. evidence of fetal infection.
2. chorioamnionitis.
3. fetal anomalies.
4. abnormal fetal karyotype
5. patient withdrawal from the study and/or unavailability for follow-up.

Primary outcomes:
measure: obtaining clear images for fetal cardiac structures via standard views which is 4 chamber view[4CH.], left outflow tract view[LVOT.] , right outflow tract view [RVOT.], three vesseles trachea view [3VTV.]
timeFrame: 15 miutes
Secondary outcomes:
Other outcomes:
Locations:
city: Assuit
country: Egypt
facility: Assiut university
Study officials:
References:
Clinical trial NCT05853523: The Desensitizing Treatment Effects of the Laser and Ozone on Dentin Hypersensitivity: In-vivo Comparison
Official title: The Desensitizing Treatment Effects of the Laser and Ozone on Dentin Hypersensitivity: In-vivo Comparison
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Dentin Sensitivity
Lead sponsor: University of L'Aquila
Sponsor class: OTHER
First posted: 2023-05-10
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Split Mouth: all patients involved received both treatments randomly assigned to either the right or left halves of the dentition.
Primary purpose: TREATMENT

Brief summary: The goal of this split mouth clinical trial is to compare clinical efficacy of diode laser and gas ozone in the treatment of dentine hypersensitivity (DHS) of non-carious-cervical lesion. The main questions it aims to answer are:

* gas ozone affects dentine hypersensitivity?
* diode laser affects dentine hypersensitivity? Participants, affected of DHS , were treated with gas ozone and diode laser.The pain severity was quantified according to the Visual Analogue Scale (VAS) before and after the treatmens.


Eligibility criteria: Inclusion Criteria:

* Stimulated dentine hypersensitivity greater than 6 on visual analogue scale (VAS)
* DHS affected two teeth, not contiguous, of different mouth semiarch.

Exclusion Criteria:

* Periodontal surgery in the last 3 month
* Use of desensitizing paste in the last 3 month
* Pregnant or breastfeeding state
* Teeth with caries, reconstructions, pulpits congenital anomalies, fracture, and occlusal interferences.

Primary outcomes:
measure: Change from Baseline in Pain on the 10-point Visual Analogue Scale (VAS) immediately after treatment
timeFrame: 5 minutes
measure: Pain on the 10-point Visual Analogue Scale (VAS) at 3 months from treatment
timeFrame: 3 months
measure: Pain on the 10-point Visual Analogue Scale (VAS) at 6 months from treatment
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: L'Aquila
country: Italy
facility: University of L'Aquila
state: AQ
Study officials:
affiliation: University of L'Aquila
name: Maurizio D'Amario
role: PRINCIPAL_INVESTIGATOR
References:
citation: Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. J Clin Periodontol. 1997 Nov;24(11):808-13. doi: 10.1111/j.1600-051x.1997.tb01194.x.
Clinical trial NCT02617823: Influence of Maternal Postioning on Spread of Local Anesthetic After Epidural Analgesia
Official title: Influence of Maternal Postioning on Spread of Local Anesthetic After Epidural Analgesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Effects of; Anesthesia, Spinal and Epidural, in Pregnancy
Lead sponsor: Region Skane
Sponsor class: OTHER
First posted: 2015-12-01
Enrollment: 950
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if a lateral positioning of the pregnant woman after epidural analgesia increases the incidence of unilateral functioning epidurals.

Detailed description: Pregnant women requesting epidural analgesia will be randomized to either left lateral or semi-recumbent position for 30 minutes after the first epidural bolus-injection.

After 30 minutes, the clinical effect of the analgesia will be evaluated by an anesthesiologist if available or by a midwife if the anesthesiologist is unavailable. The study-period is concluded thereafter and further positioning is optional.

Maternal and fetal wellbeing are continuously being monitored during the study period and complications/interventions registered. APGAR and CTG results during the intervention will be registered and evaluated at a later stage.

Eligibility criteria: Inclusion Criteria:

* all adult pregnant women recieiving epidural analgesia

Exclusion Criteria:

* participation refused
* inability to understand study purpose/instructions
* study postition could not be maintained for 30 min
* ineffective epidural

Primary outcomes:
measure: unilateral analgesic effect
timeFrame: evaluation of epidural effect after 30 min
Secondary outcomes:
measure: maternal comfort and safety in regards to blood pressure and/or unexpected neurological effects from epidural analgesia
timeFrame: evaluation of epidural effect after 30 min
measure: fetal/neonatal safety measured with CTG and APGAR score
timeFrame: CTG from start of study until birth, APGAR 2, 5 and 10min after birth
Other outcomes:
Locations:
city: Lund
country: Sweden
facility: University Hospital SUS
state: Skane
city: Malmo
country: Sweden
facility: University Hospital SUS
state: Skane
Study officials:
affiliation: Region Skane, Head of the Department of Anesthesia and Intensive Care, University Hospital SUS
name: Carolina Samuelsson, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT02624323: Ultrasound Guided Axillary Versus Jugular Central Venous Catheterization
Official title: Real-time Ultrasound-guided Axillary and Jugular Vein Catheterization: A Prospective Comparison in Mechanically Ventilated Critically Ill Patients. A Randomized Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Critical Illness
Keywords: ultrasonography
catheterization
central line
mechanical ventilation
intensive care
axillary vein
jugular vein
randomization
Lead sponsor: Uniwersytecki Szpital Kliniczny w Opolu
Sponsor class: OTHER
First posted: 2015-12-08
Enrollment: 614
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The main intention of this study is to compare two ultrasound-guided central venous catheterization procedures namely: real-time, ultrasound-guided, in plane axillary vein catheterization and real-time, ultrasound-guided, out of plane jugular vein catheterization in terms of venipuncture, catheterization success, early mechanical complication and catheter-related infection rate in mechanically ventilated patients admitted to the intensive care unit.


Eligibility criteria: Inclusion Criteria:

* mechanically ventilated intensive care patients with clinical indications for central venous line placement

Exclusion Criteria:

* trauma and hematoma at the catheterization site
* major blood coagulation disorders coincided with active bleeding
* anatomical abnormalities at the catheterization site
* infection at the catheterization site
* age less than 18 years
* lack of patients or closest relatives consent

Primary outcomes:
measure: Procedure success rate
timeFrame: 24 hours
Secondary outcomes:
measure: Incidence of Catheter colonization
timeFrame: 1 month
measure: Incidence of catheter-related bloodstream infection
timeFrame: 1 month
measure: Procedure complication rate
timeFrame: 24 hours
Other outcomes:
Locations:
city: Opole
country: Poland
facility: Department of Anesthesiology and Intensive Care, Uniwersytecki Szpital Kliniczny w Opolu
state: Silesia
city: Lublin
country: Poland
facility: 2nd Department of Anesthesiology and Critical Care, Medical University of Lublin
Study officials:
affiliation: Department of Anesthesiology and Intensive Care, Uniwersytecki Szpital Kliniczny w Opolu
name: Tomasz Czarnik, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06123923: Trends of Vitreoretinal Surgery in Children
Official title: Contemporary Patterns and Underlying Causes of Vitrectomy in Pediatric and Adolescent Patients: A Nationwide, Population-Based Analysis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Vitreoretinal Disease
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2023-11-09
Enrollment: 3509
Sex: ALL
Minimum age (years): 0
Maximum age (years): 19
Standard ages: CHILD
ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: all pediatric and adolescent subjects under 20 years of age in Korean population

Brief summary: Purpose: We determined the incidence, etiology, and longitudinal trends of vitreoretinal diseases necessitating pars plana vitrectomy (PPV) in the pediatric and adolescent population.

Design: This was a nationwide, population-based cohort study, utilizing data from the Korean National Health Claims database spanning from 2009 to 2020.

Given the retrospective design of the study and the anonymized nature of the data, the requirement for informed consent was waived.

Methods: All pediatric and adolescent patients (under 20 years of age) who underwent PPV across the Korean population were included. The cumulative incidence of PPV was estimated from 2009 to 2020, with 2009 to 2011 as the washout period. The annual trends of PPV incidence, the proportion of each etiology, and comorbidity were estimated based on sex and specific age groups.


Eligibility criteria: Inclusion Criteria:

* We included all pediatric and adolescent patients who underwent complete PPV (registered under code S5121) during the study period from January 2009 to December 2020, and who were continuously enrolled in a medical plan, in our estimates.

Primary outcomes:
measure: number of vitreoretinal surgery
timeFrame: 2009-2020
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Kunho Bae, MD
role: STUDY_CHAIR
References:
Clinical trial NCT01900223: Chronic Pain After Shoulder Arthroplasty
Official title: Chronic Pain After Shoulder Arthroplasty: Epidemiology and Risk Factors.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Pain
Lead sponsor: University of Aarhus
Sponsor class: OTHER
Collaborators: name: Central Denmark Region
name: Augustinus Fonden
name: Horsens Hospital
First posted: 2013-07-16
Enrollment: 786
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients in the Danish Shoulder Arthroplasty Register

Brief summary: Chronic pain is relatively common after different types of surgery. The investigators intend to study prevalence, characteristics and risk factors of chronic pain after shoulder arthroplasty, focusing on neuropathic pain characteristics, and risk factors such as preoperative pain, severe acute postoperative pain, age, gender, and pain elsewhere.


Eligibility criteria: Inclusion Criteria:

* Patients operated with any shoulder prosthesis between april 2011 and april 2012 in Denmark

Exclusion Criteria:

* Secondary prosthesis
* Bilateral prosthesis
* Age below 18
* Reoperated in the same shoulder after the prosthesis

Primary outcomes:
measure: Current pain intensity
timeFrame: At time of completing the questionnaire, which is sent to patients 1-2 years after their shoulderprosthesis.
Secondary outcomes:
measure: preoperative pain intensity
timeFrame: recalled
Other outcomes:
Locations:
Study officials:
affiliation: Aarhus University, Horsens Hospital
name: Karen T Bjørnholdt, M.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Aarhus University Hospital
name: Birgitte Brandsborg, M.D., Ph.D.
role: STUDY_CHAIR
affiliation: Aarhus University Hospital
name: Lone Nikolajsen, M.D., DMSc
role: STUDY_CHAIR
affiliation: Aarhus University Hospital
name: Kjeld Søballe, M.D., DMSc
role: STUDY_CHAIR
References:
Clinical trial NCT04697823: Effect of Hyaluronan-enriched Medium on the Cumulative Ongoing Pregnancy Rate.
Official title: Effect of Hyaluronan-enriched Medium on the Cumulative Ongoing Pregnancy Rate: a Prospective Randomized Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Hyaluronan-EnRiched Medium
Randomized Controlled Trial
Lead sponsor: KU Leuven
Sponsor class: OTHER
First posted: 2021-01-06
Enrollment: 400
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Assessing whether the use of hyaluronan-enriched transfer medium can increase the cumulative ongoing pregnancy rate


Eligibility criteria: Inclusion Criteria:

* Patients with own oocytes/embryos;
* Patients with female age at 1st OR in the study \<40 year;
* Patients planned for a 2nd oocyte retrieval, with no clinical ongoing pregnancy after the previous oocyte retrieval
* Patients planned for a 3rd oocyte retrieval with no clinical ongoing pregnancy after previous oocyte retrievals
* Patients with female age at 1st OR in the study \<40 year;
* Patients with BMI ≤32;
* Patients with written informed consent;

Exclusion Criteria:

-

Primary outcomes:
measure: number of transfers needed to reach ongoing pregnancy
timeFrame: ongoing defined as a pregancy with a viable fetus with FHB at 12 weeks of pregnancy
Secondary outcomes:
measure: number of transfers needed to reach clinical pregnancy, life birth, miscarriage, multiple pregnancy
timeFrame: until Live birth: 9 months after ET
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: Leuven University Fertility Center
Study officials:
References:
Clinical trial NCT03500523: Corneal Biomechanical Properties in Pregnancy
Official title: Corneal Biomechanical Properties in Pregnancy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Corneal Biomechanics
Pregnancy
Lead sponsor: Medipol University
Sponsor class: OTHER
First posted: 2018-04-18
Enrollment: 83
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: 57 eyes of 57 healthy pregnant women who were visiting Obstetrics and Gynecology department for routine examination and 26 eyes of 26 non pregnant control subjects who were at the first week of the menstrual cycle were enrolled in the study. All subjects had a detailed ophthalmologic examination including the best corrected visual acuity with a Snellen chart, slit- lamp biomicroscopic evaluation, and indirect fundoscopy. The biomechanical properties Corneal Hysteresis, Corneal resistance factor, corneal compensated intraocular pressure and Goldmann-correlated intraocular pressure values were measured with ORA (Ocular Response Analyzer, software version 1.02, Reichert, Inc.) Central corneal thickness was measured with a built-in ultrasonic pachymeter attached to the ORA device.Axial length , Anterior chamber depth , and keratometry readings were acquired with an ocular biometer (IOLMaster; Carl-Zeiss Meditec, Inc.) before CCT determinations had been taken. Results of these parameters were compared between pregnant group and healthy control group.


Eligibility criteria: Inclusion Criteria:

* 57 eyes of 57 healthy pregnant women who were visiting Obstetrics and Gynecology department for routine examination and 26 eyes of 26 non pregnant control subjects who were at the first week of the menstrual cycle were included in the study.

Exclusion Criteria:

* Exclusion criteria included history of intraocular surgery or refractive surgery, history of glaucoma or glaucoma suspicion, contact lens wear, systemic autoimmune disease or diabetes and usage of eye drop and oral contraceptives.

Primary outcomes:
measure: changes of corneal hysteresis during pregnancy
timeFrame: three months
measure: changes of corneal resistance factor during pregnancy
timeFrame: three months
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Funda Dikkaya
Study officials:
References:
Clinical trial NCT05965323: Reopening Schools Safely and Educating Youth Research- Early Learning Ancillary Study
Official title: Reopening Schools Safely and Educating Youth Research- Early Learning Ancillary Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Absenteeism
Keywords: SARS-coV-2
School re-opening
Rural Communities
Early Education - pre School
Risk communication
Lead sponsor: University of Washington
Sponsor class: OTHER
Collaborators: name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
First posted: 2023-07-28
Enrollment: 97
Sex: ALL
Minimum age (years): 3
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This is a single arm, pre/post intervention study to a larger trial that will examine the effect of health education with comic books and videos on COVID-19 preventive behaviors (masking, social distancing, testing and vaccine uptake). The participants are students, ages 3-5 years old and their parents.

Detailed description: This is a single arm, pre/post intervention study to a larger trial that will examine the effect of health education with comic books and videos on COVID-19 preventive behaviors (masking, social distancing, testing and vaccine uptake). The participants are students, ages 3-5 years old and their parents.

Students will receive the intervention from November 2023 to March 2024.

Eligibility criteria: Inclusion Criteria:

* Must have a child attending the Early Learning Program in the Yakima School District
* Must be able to provide informed consent and legal guardian assent either virtually, on the telephone, or in-person.
* Must have a permanent mailing address available for study staff to mail necessary materials OR a working email address.
* Must speak English or Spanish.

Exclusion Criteria:

- Not in Early Learning program in Yakima School District

Primary outcomes:
measure: Testing
timeFrame: Up to eleven months
measure: Masking
timeFrame: Up to eleven months
measure: Wash Hands
timeFrame: Up to eleven months
measure: Hide Cough
timeFrame: Up to eleven months
Secondary outcomes:
Other outcomes:
Locations:
city: Seattle
country: United States
facility: University of Washington
state: Washington
Study officials:
affiliation: University of Washington
name: Linda Ko, PhD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00969423: Chronic Pain After Video-assisted Thoracoscopic Surgery (VATS) Surgery for Pneumothorax
Official title: Chronic Pain After VATS Surgery for Pneumothorax
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Pneumothorax
Keywords: persistent pain
neuropathic pain
Chronic Pain
VATS
Primary spontaneous pneumothorax patients
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
First posted: 2009-09-01
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The study will investigate characteristics of chronic pain after VATS surgery with two different sizes of videoscopic equipment.


Eligibility criteria: Inclusion Criteria:

* PSP
* Able to understand and give consent
* Can read
* Residing in Denmark

Exclusion Criteria:

* Unable to understand the written information in Danish
* Abuse (Medicine, Drugs, Alcohol)
* Severe psychiatric Illness
* Conflicting neurological disease
* Conversion to open surgery
* Use of neuroaxial analgesia
* Use of electric cauterizer necessitated
* Additional thoracic surgery in the investigation period

Primary outcomes:
measure: QST score
timeFrame: 2 years
measure: Post surgical pain
timeFrame: 2 years
Secondary outcomes:
measure: Patient related factors, depression, coping etc.
timeFrame: 2 years
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Rigshospitalet
Study officials:
affiliation: Section for Surgical Pathophysiology 4074 Copenhagen, Denmark
name: Kim Wildgaard, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wildgaard K, Ravn J, Kehlet H. Chronic post-thoracotomy pain: a critical review of pathogenic mechanisms and strategies for prevention. Eur J Cardiothorac Surg. 2009 Jul;36(1):170-80. doi: 10.1016/j.ejcts.2009.02.005.