Clinical trial NCT03024203: A Comparison of Cognitive Training Approaches in Psychotic Disorders
Official title: A Comparison of Cognitive Training Approaches in Psychotic Disorders
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Psychotic Disorders
Lead sponsor: Queen's University
Sponsor class: OTHER
First posted: 2017-01-18
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Cognitive remediation (CR) is the best treatment to improve neurocognitive abilities for individuals with psychosis, however, there is no gold standard method of cognitive remediation available. Cognitive training refers to the training component of CR in which people practice computerized exercises that train specific cognitive abilities. There is no agreed upon approach within the field as to the type of training that is most effective with some studies, training higher level cognitive abilities, some training perceptual abilities, and others training general cognitive skills. This study will directly compare two competing methods of cognitive training on measures of neurophysiology, neurocognition, functional competence, and real-world functional performance.


Eligibility criteria: Inclusion Criteria:

* psychotic disorder
* No previous cognitive remediation in past 6 months

Exclusion Criteria:

* Brain injury
* Substance abuse
* Neurocognitive disorder
* Developmental Disability

Primary outcomes:
measure: Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline
timeFrame: Post-treatment (within 2 weeks following the end of treatment)
Secondary outcomes:
measure: Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline
timeFrame: Post-treatment (within 2 weeks following the end of treatment)
measure: Change in Neurophysiology - EEG from Baseline
timeFrame: Post-treatment (within 2 weeks following the end of treatment)
measure: Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline
timeFrame: Post-treatment (within 2 weeks following the end of treatment)
measure: Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline
timeFrame: Follow-Up (3 months after the end of treatment)
measure: Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline
timeFrame: Follow-Up (3 months after the end of treatment)
measure: Change in Neurophysiology - EEG from Baseline
timeFrame: Follow-Up (3 months after the end of treatment)
measure: Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline
timeFrame: Follow-Up (3 months after the end of treatment)
Other outcomes:
Locations:
city: Kingston
country: Canada
facility: Queen's University
state: Ontario
Study officials:
References:
citation: Best MW, Milanovic M, Iftene F, Bowie CR. A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning. Am J Psychiatry. 2019 Apr 1;176(4):297-306. doi: 10.1176/appi.ajp.2018.18070849. Epub 2019 Mar 8.