Clinical trial NCT05800379: Study on Hospitalization of Children With Bronchial Asthma
Official title: Study on Hospitalization of Children With Bronchial Asthma
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Asthma in Children
Keywords: asthma
children
mucus plug
Flexible bronchoscope
Lead sponsor: Beijing Children's Hospital
Sponsor class: OTHER
First posted: 2023-04-05
Enrollment: 470
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children admitted with acute episodes of asthma

Brief summary: Bronchial asthma is the most common chronic respiratory disease in children. At present, more attention has been paid to the treatment of airway inflammation and smooth muscle spasm, while the related research on the risk factors of asthma attack, mucus plug formation and its effect on asthma has been ignored. This study was a retrospective study. Children hospitalized for acute exacerbation of asthma from 2016 to 2021 were selected as the research objects. The clinical manifestations, bronchoscopy results and lung CT results of children hospitalized for acute exacerbation of asthma were summarized. To analyze the risk factors of acute exacerbation, clinical characteristics, risk factors of mucus plug formation in hospitalized children with asthma, and the safety and efficacy of flexible bronchoscopy in the diagnosis and treatment of hospitalized children with asthma. The discharged children were investigated by written or online questionnaires to understand the acute attack of asthma, control level, compliance, appliability of the China Children's Asthma Action Plan, family management and medical utilization of children with asthma after discharge.

Detailed description: Asthma is the most common chronic respiratory disease in children. The prevalence of asthma in children in China increased by nearly 50% in 2010 compared with 2000, and the proportion of children hospitalized for asthma exacerbation also increased. China has a large population base, and the number of children with asthma is large. Acute asthma attack is mainly characterized by airway smooth muscle contraction and mucus plug obstruction. At present, more attention has been paid to the treatment of airway mucosal inflammation and smooth muscle spasm, while the related research on the risk factors of asthma acute attack, mucus plug formation and its effect on asthma has been ignored. Bronchoscopy can directly and effectively remove the mucus plug formed in the airway of children with asthma, but there is a lack of clear application standards and procedures. Identifying the risk factors of mucus plug formation in hospitalized children with asthma exacerbation, identifying mucus plug, timely and targeted treatment, and education and training after discharge are of great significance to reduce the hospitalization rate and mortality.This study was a retrospective study. Children hospitalized for acute exacerbation of asthma from 2016 to 2021 were selected as the research objects. The clinical manifestations, bronchoscopy results and lung CT results of children hospitalized for acute exacerbation of asthma were summarized. To analyze the risk factors of acute exacerbation, clinical characteristics, risk factors of mucus plug formation in hospitalized children with asthma, and the safety and efficacy of flexible bronchoscopy in the diagnosis and treatment of hospitalized children with asthma. The discharged children were investigated by written or online questionnaires to understand the acute attack of asthma, control level, compliance, appliability of the China Children's Asthma Action Plan, family management and medical utilization of children with asthma after discharge.

Eligibility criteria: Inclusion Criteria:

• Children admitted with acute episodes of asthma between January 2016 and December 2021

Exclusion Criteria:

* Basic information is incomplete
* Lack of relevant information on diagnosis and treatment after admission
* Those who disagree with the telephone follow-up
* Basic diseases such as heart, liver and kidney
* Children with primary or secondary immunodeficiency, genetic metabolic diseases, tumors, or after organ or hematopoietic stem cell transplantation
* Active pulmonary tuberculosis and children with a history of asthma who are hospitalized for other reasons

Primary outcomes:
measure: Clinical characteristics of hospitalized children with acute asthma attack
timeFrame: From January 2016 to December 2021
measure: Influencing factors of acute attack severity in hospitalized children with asthma
timeFrame: From January 2016 to December 2021
measure: Risk factors for acute exacerbation of asthma with respiratory failure in children
timeFrame: From January 2016 to December 2021
measure: Risk factors for mucus plug formation in hospitalized children with asthma exacerbation
timeFrame: From January 2016 to December 2021
measure: Identification of mucus plugs in hospitalized children with asthma
timeFrame: From January 2016 to December 2021
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Children's Hospital affiliated to Capital Medical University
Study officials:
affiliation: Beijing Children's Hospital
name: kunling shen, doctor
role: PRINCIPAL_INVESTIGATOR
References: