Clinical trial NCT03967210: Epidemiological, Clinical, Microbiological and Outcome Description of Patients With Klebsiella sp Meningitis
Official title: Epidemiological, Clinical, Microbiological and Outcome Description of Patients With Klebsiella sp Meningitis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Meningitis
Lead sponsor: Fondation Hôpital Saint-Joseph
Sponsor class: OTHER
First posted: 2019-05-30
Enrollment: 132
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient with meningitis Klebsiella sp., hospitalized in one of the hospitals of the Clinical Microbiology Group between 2008 and 2018.

Brief summary: Klebsiella pneumoniae is implicated in the occurrence of severe pneumonia. Most Klebsiella pneumoniae infections are associated with care and occur in patients with compromised immune defenses. More recently, cases of hepatic abscess and acute community meningitis related to strains of Klebsiella pneumoniae have been reported. The mortality of these infections is important, most often due to a delayed diagnosis. The poor prognostic factors reported in the literature for very low numbers are: advanced age, coma, septic shock, glyceryachia \<10mg / dL and proteinuria\> 750 mg / dL. In addition, no study has specifically focused on the factors of occurrence and factors associated with Klebsiella sp. Indeed, meningitis related to Klebsiella pneumoniae seems to be a rare but probably underestimated event whose risk factors, clinical presentation, microbiological are little known and the treatment modalities of this severe infection are not codified.


Eligibility criteria: Inclusion Criteria:

* Man or Woman whose age ≥ 18 years
* Patient with meningitis Klebsiella sp., hospitalized in one of the hospitals of the Clinical Microbiology Group
* Francophone patient

Exclusion Criteria:

* Patient under tutorship or curatorship
* Patient deprived of liberty
* Patient under safeguard of justice
* Patient opposing his participation

Primary outcomes:
measure: Characterize meningitis with Klebsiella pneumoniae
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Brest
country: France
facility: CHU Brest
city: Caen
country: France
facility: CHU Caen
city: Créteil
country: France
facility: Hôpital henri Mondor
city: Lyon
country: France
facility: CHU Lyon
city: Nantes
country: France
facility: CHU Nantes
city: Nice
country: France
facility: CHU Nice
city: Paris
country: France
facility: Hôpital Lariboisière
city: Paris
country: France
facility: Groupe Hospitalier Paris Saint-Joseph
city: Paris
country: France
facility: Hôpital Cochin
city: Paris
country: France
facility: CHU Kremlin Bicetre
city: Paris
country: France
facility: Hôpital Foch
city: Paris
country: France
facility: Hôpital Necker Enfants Malades
city: Paris
country: France
facility: Hôpital Sainte Anne
city: Poitiers
country: France
facility: CHU Poitiers
city: Reims
country: France
facility: CHU Reims
city: Rennes
country: France
facility: CHU Rennes
city: Strasbourg
country: France
facility: CHU Strasbourg
city: Tours
country: France
facility: CHU Tours
Study officials:
affiliation: Fondation Hôpital Saint-Joseph
name: Benoit PILMIS, MD
role: STUDY_DIRECTOR
References: