louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05538143: Improving Management of Emergency Department Patients With Undifferentiated Syncope: Prospective Validation of the Canadian Syncope Risk Score
Official title: Improving Management of Emergency Department Patients With Undifferentiated Syncope: Prospective Validation of the Canadian Syncope Risk Score
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Syncope
Lead sponsor: Kaiser Permanente
Sponsor class: OTHER
First posted: 2022-09-13
Enrollment: 4000
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients presenting to KPNC emergency departments with eligibility criteria

Brief summary: Among Kaiser Permanente Northern California (KPNC) health plan members, age ≥16 years, with recent syncope and presyncope undergoing emergency department (ED) management with a point-of-care clinical decision support (CDS) tool, how well does the Canadian Syncope Risk Score predict 30-day serious outcomes that were not evident during index ED evaluation?


Eligibility criteria: Inclusion Criteria:

* Age ≥16y
* Member of Kaiser Permanente Northern California (KPNC) health plan
* Presentation to the ED with an ED diagnosis of recent syncope or presyncope (\<24h) without a serious etiology identified during the initial ED diagnostic assessment, that is, patients with unexplained syncope.
* Subjects who meet criteria will be identified electronically within the CDS tool in the electronic health record.

Exclusion Criteria:

* Age \<16 years old
* Non-members of KPNC
* Patients with obvious witnessed seizure, prolonged loss of consciousness (\>5 minutes), post-traumatic loss of consciousness, and new mental status changes
* Patients requiring hospitalization for traumatic injuries (e.g., syncope leading to motorized vehicle collision), because their outcomes may be related to trauma rather than syncope
* Patients with impaired communication capacity, e.g., intoxication, language barriers, and dementia.

Primary outcomes:
measure: Number of patients with arrhythmic and nonarrhythmic serious outcomes
timeFrame: 30 days
Secondary outcomes:
Other outcomes:
Locations:
city: Oakland
country: United States
facility: Kaiser Permanente Oakland Emergency Department
state: California
city: Richmond
country: United States
facility: Kaiser Permanente Richmond Emergency Department
state: California
city: Roseville
country: United States
facility: Kaiser Permanente Roseville Emergency Department
state: California
city: Sacramento
country: United States
facility: Kaiser Permanente South Sacramento Emergency Department
state: California
city: Sacramento
country: United States
facility: Kaiser Permanente Sacramento Emergency Department
state: California
Study officials:
References:
Clinical trial NCT06901843: Comparative Effects of Closed Kinetic Chain Exercises and Mobilization Exercises in Elderly Females With NFF
Official title: Comparative Effects of Closed Kinetic Chain Exercises and Mobilization Exercises in Elderly Females With Neck of Femur Fracture
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Neck of Femur Fracture
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2025-03-30
Enrollment: 44
Sex: FEMALE
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study investigates the additional benefits of Mobilization Exercises and Closed Kinetic Chain Exercises (CKCE) in elderly individuals with post-operative neck of femur fracture. The researcher employs a randomized controlled trial which will involve 49 participants aged above 65 years with post-operative neck of femur fracture.

Detailed description: Participants are divided into two groups:

one receiving Mobilization Exercises, and the other receiving Closed Kinetic Chain Exercises. Outcomes are assessed over a 6 week period, focusing on pain intensity, Range of motion, risk of fall by goniometer, visual analogue scale (VAS) and dynamic gait index (DGI) scores. Data will be analyzed using SPSS-23. The study will conclude whether CKCE or Mobilization exercises offer a significant benefit in pain reduction, prevent risk of falls and range of motion.

Eligibility criteria: Inclusion Criteria:

* Diagnosed by Orthopedic Surgeon with neck of femur fracture by x ray findings
* Patients undergone surgical treatment for neck of femur fracture within one year.
* Patients administer in groups after 12 weeks of post-operative period
* X-ray reexamination with no fracture or dislocation before treatment
* Ability to walk normally or with crutches
* Patients walk without any assistance before injury
* Un-displaced neck of femur fracture according to Garden Classification
* Operated on using internal fixation
* Only females were included
* Aged 65 years or older

Exclusion Criteria:

* Bilateral hip fracture
* Bedridden patient before fracture
* Patient who have undergone any previous surgery of lower limb
* Neurological Condition

Primary outcomes:
measure: Visual Analogue Scale (VAS)
timeFrame: 12 Months
measure: Dynamic Gait Index (DGI)
timeFrame: 12 months
measure: GONIOMETER
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Bajwa hospital J7JP+4WH, GT Rd, Shahdara Town, Shahdara
state: Punjab
Study officials:
References:
Clinical trial NCT05090943: Adult Tic Disorders Registry
Official title: Adult Tic Disorders Registry
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Tic Disorders
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2021-10-25
Enrollment: 450
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient with tics disorders

Brief summary: The purpose of this study is to develop the adult tic disorders registry in order to characterize the relationship between tic severity and tic-related impairment in women compared to men with tic disorders.


Eligibility criteria: Inclusion criteria :

1. Age \>18 years
2. Patients with Tic disorders
3. Given the non-opposition

Non Inclusion criteria

1. No affiliation to a French health social insurance
2. Significant congenital disorders that may affect understanding of assessments
3. Patients under guardianship or curatorship

Primary outcomes:
measure: Correlation between Quality of Life and TICs severity
timeFrame: 6 months
Secondary outcomes:
measure: Change in TICs
timeFrame: 6 months
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand
city: Limoges
country: France
facility: CHU Limoges
city: Marseille
country: France
facility: CHU Marseille
city: Paris
country: France
facility: Service de Neurologie, GH Pitié Salpêtrière
city: Poitiers
country: France
facility: CHU Poitiers
city: Saint-Herblain
country: France
facility: CHU Nantes
city: Strasbourg
country: France
facility: CHU Strasbourg
Study officials:
References:
Clinical trial NCT04299243: Clinical Trial Protocol for Safety and Efficacy of Soft Contact Lens
Official title: Clinical Trial Protocol for Safety and Efficacy of Soft Contact Lens (Model: Spherical Lens)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myopia
Lead sponsor: Menicon Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2020-03-06
Enrollment: 148
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This project is a multi-center, randomized, parallel-controlled, non-inferior clinical trial of soft contact lenses.

Detailed description: The test product is the Soft Contact Lens (model: Spherical Lens), and the control product is a commercially available soft contact lens (model: SiHy Daily). The number of enrolled subjects is 148, and clinical observation is performed for 3 months.

Eligibility criteria: Inclusion Criteria:

* Male or female with age of 18 to 45
* Spherical power: -0.25 to -10.00D
* Cylinder power ≤0.75D and Sph.P:Cyl.P≥3:1, or 1.00D≤ cylinder power ≤1.50D and Sph.P:Cyl.P ≥4:1;
* Both eyes are ametropia, and there is no case where the investigator believes that the soft contact lens cannot be worn;

  : The case of wearing a soft contact lens as referred to in this trial is: i) No eyelid abnormalities or infections; ii) No clinically significant slit lamp findings iii) No other active eye diseases.
* BCVA of the left and right eye subjective refraction is greater than or equal to 5.0.

Exclusion Criteria:

* Need to use therapeutic ophthalmic drugs, including antibiotics, hormones and compound ophthalmic drugs containing hormones
* Dry eye syndrome
* Any systemic disease contraindications to contact lenses or disease medications can affect the wearing of contact lenses
* Wearing a hard contact lens in the past 6 weeks
* Tear film break-up time is less than or equal to 5s
* Allergic to contact lenses and/or contact lenses
* Keratoconus or other irregular corneal patients
* Soft hydrophilic contact lens wearers are affected by long-term special conditions such as dryness, severe dust or volatile chemicals
* Pregnant, lactating or plan to be pregnant
* Only one eye meets the requirements for enrollment
* Participating in other clinical trials or less than ten days after the end of a soft contact lens clinical trial
* Less than three months after the end of a drug clinical trial
* Determined by the investigator that could not be enrolled

Primary outcomes:
measure: The ratio of corrected visual acuity of left and right eyes is ≥5.0
timeFrame: 1 week
measure: The occurrence of adverse events
timeFrame: 3 month
Secondary outcomes:
measure: BCVA (spectacles) and BCVA (CL)
timeFrame: 1 week, 1 month, 3 months
Other outcomes:
Locations:
city: Tianjin
country: China
facility: Tianjin Eye Hospital
Study officials:
affiliation: Tianjin Eye Hospital
name: Li Lihua, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01376843: Conversion Rate of (TST) Tuberculin Skin Test and Quantiferon-TB Gold In Tube Assay in Health Care Workers
Official title: Conversion Rate of TST and Quantiferon-TB Gold In Tube Assay in Health Care Workers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tuberculosis
Keywords: latent tuberculosis in health care workers
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2011-06-20
Enrollment: 53
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: health care workers who performed TST or Quantiferon-TB Gold In tube assay before

Brief summary: The purpose of this study is to access conversion rate of TST (Tuberculin skin test) and Quantiferon-TB Gold In tube assay in health care workers.


Eligibility criteria: Inclusion Criteria:

* age 20-75, men and women
* participant who was enrolled in the study of latent tuberculosis in health care worker (IRB No.4-2009-0187)
* high risk or low risk health care worker who was performed TST or Quantiferon-TB Gold In tube assay before

Exclusion Criteria:

* age \< 20
* person who don't agree with enrollment
* illiterate
* person who is diagnosed as active tuberculosis now
* person who has history of hypersensitivity on PPD (tuberculin purified protein derivative)
* pregnant woman
* person who is treated as active tuberculosis

Primary outcomes:
measure: conversion rate of latent tuberculosis infection in hospital workers
timeFrame: 3months
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
Study officials:
References:
citation: Menzies D, Fanning A, Yuan L, Fitzgerald M. Tuberculosis among health care workers. N Engl J Med. 1995 Jan 12;332(2):92-8. doi: 10.1056/NEJM199501123320206. No abstract available.
citation: Jiamjarasrangsi W, Hirunsuthikul N, Kamolratanakul P. Tuberculosis among health care workers at King Chulalongkorn Memorial Hospital, 1988-2002. Int J Tuberc Lung Dis. 2005 Nov;9(11):1253-8.
citation: Schwartzman K, Loo V, Pasztor J, Menzies D. Tuberculosis infection among health care workers in Montreal. Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1006-12. doi: 10.1164/ajrccm.154.4.8887599.
citation: Kruuner A, Danilovitsh M, Pehme L, Laisaar T, Hoffner SE, Katila ML. Tuberculosis as an occupational hazard for health care workers in Estonia. Int J Tuberc Lung Dis. 2001 Feb;5(2):170-6.
Clinical trial NCT02986243: Preparing for Kidney Transplant by Attaining a Healthy Weight
Official title: Preparing for Kidney Transplant by Attaining a Healthy Weight
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Kidney Transplant
Lead sponsor: University of Chicago
Sponsor class: OTHER
First posted: 2016-12-08
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if an assigned physical fitness program will result in weight loss to prepare patients for kidney transplant.

Detailed description: The goal of this study is to prepare subjects for kidney transplant. Patients who are in need of a kidney transplant but are unable to be place on the wait list due to weight will be enrolled in a six month workout program. The workout program will consist of counseling from a registered dietician, personal training from certified trainers and constant health monitoring.

Eligibility criteria: Inclusion Criteria:

* Adult patients over 18 years of age and older but less than 65
* All patients who are currently listed as "inactive" on the University of Chicago kidney transplant wait list
* Those with a body mass index of 40-44
* Those with access to the Internet
* Have transportation to the fitness center (Formula Fitness Center at Union Station location)

Exclusion Criteria:

* Those patients who are listed "inactive" on the wait-list due to co-morbid conditions other than obesity
* Those who are unwilling to attend fitness center appointments
* Those who do not have adequate transportation to the fitness center
* Those who do not have access to the Internet
* Those who are not comfortable navigating and using the Internet

Primary outcomes:
measure: Weight Loss
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04221243: Evaluation Of Innovative 3D Printed Space Maintainer Versus Conventional One
Official title: Evaluation Of Innovative 3D Printed Space Maintainer Versus Conventional One
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Missing Teeth
Keywords: space maintainer
3D printing
Lead sponsor: British University In Egypt
Sponsor class: OTHER
First posted: 2020-01-09
Enrollment: 30
Sex: ALL
Minimum age (years): 6
Maximum age (years): 9
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The primary aim of this study is to introduce a new effective and efficient 3D printed design of an intra-oral space maintainer.

The secondary aim of the study is to:

Evaluate the clinical performance of 3D printed space maintainer versus conventional metal band and loop over a period of 6 months regarding their functional , biological aspects and patient satisfaction.

Detailed description: And will be conducted as follows:

* In-Vivo evaluation of the clinical performance of 3D printed space maintainer versus metal band and loop concerning oral hygiene, retention and patient satisfaction.
* A total of thirty healthy subjects will be selected from the Pediatric Dentistry and Dental Public Health outpatient clinic, Faculty of Dentistry, Ain Shams University. They will be divided using simple randomization in two groups:

Group 1: Children with 3D printed space maintainer (n=15) Group 2: Children with conventional band and loop(n=15)

Eligibility criteria: Inclusion Criteria:

* Aged 6-9years' old
* Premature loss of primary molar or molars in one or more quadrant.
* Absence of abnormal dental conditions such as cross bite.
* Sound and healthy buccal and lingual surfaces of abutment teeth.

Exclusion Criteria:

* Bad oral hygiene
* Medically Compromised patients.
* Presence of periapical pathology radiographically.
* Carious buccal and lingual surfaces of abutment teeth.

Primary outcomes:
measure: introduce a new 3D printed design of an intraoral space maintainer.
timeFrame: 6 months
Secondary outcomes:
measure: compare between the new 3D printed space maintainer versus conventional metal band and loop regarding their biological aspects.
timeFrame: 6 months
measure: compare between the new 3D printed space maintainer versus conventional metal band and loop regarding their patient satisfaction.
timeFrame: 6 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University
Study officials:
References:
Clinical trial NCT06520943: Comparison of Minimum Flow and Low Flow Desflurane Anesthesia in Robotic Assisted Laparoscopic Abdominal Surgery
Official title: Comparison of Minimum Flow Desflurane Anesthesia With Respiratory Parameters and Blood Gas Analyses and Low Flow Desflurane Anesthesia in Robotic Assisted Laparoscopic Abdominal Surgery
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Minimal Flow Anesthesia
Low Flow Anesthesia
Robotic Assisted Laparoscopic Abdominal Surgery
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2024-07-25
Enrollment: 70
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing robotic-assisted abdominal surgery

Brief summary: This study aims to compare the use of low fresh gas flow (1 L/min) desflurane anesthesia with minimum fresh gas flow (0.5 L/min) desflurane anesthesia in patients undergoing robotic-assisted abdominal surgery. The comparison will be based on hemodynamic and respiratory parameters. The secondary aim of our study is to compare the two different fresh gas flow methods in terms of inhalation agent consumption and soda lime consumption.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing robotic-assisted abdominal surgery

Exclusion Criteria:

* serious cardiac, respiratory, hepatic, renal, or mental disorders;
* hearing problems;
* anxiety, depression, or other psychiatric conditions;
* patient's request to leave the study

Primary outcomes:
measure: inspiratory O2 concentration
timeFrame: from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)
measure: partial oxygen pressure
timeFrame: from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)
Secondary outcomes:
measure: desflurane consumption
timeFrame: 3th hour
measure: changes in liver and kidney function tests from the preoperative values to 48 hours postoperative
timeFrame: postoperative 1st day
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara City Hospital
Study officials:
affiliation: Ankara City Hospital Bilkent
name: Betül Güven Aytaç
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02838043: The Efficacy, Safety, and Tolerability of Probiotics on the Mood and Cognition of Depressed Patients
Official title: The Efficacy, Safety, and Tolerability of Probiotics on the Mood and Cognition of Depressed Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Major Depressive Disorder
Depression
Depressive Symptoms
Lead sponsor: Queen's University
Sponsor class: OTHER
Collaborators: name: Lallemand Health Solutions
name: McMaster University
First posted: 2016-07-20
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study will be an 8-week open-label pilot study examining subjective and objective changes in mood, anxiety, cognition, and sleep before and after the introduction of a probiotic supplement containing Lactobacillus helveticus and Bifidobacterium longum in 10 treatment-naïve participants diagnosed with major depressive disorder (MDD). In order to examine the full composition of the micro biome, the investigators will also be collecting and analyzing fecal samples as well as blood samples to examine changes in plasma levels of inflammatory markers, 5-HT, and tryptophan in order to look at possible underlying mechanisms of any changes seen.


Eligibility criteria: Inclusion Criteria:

1. Diagnosis of Major Depressive Disorder (MDD) by Mini International Neuropsychiatric Interview (MINI)
2. Current depressive episode with a MADRS score of ≥ 20
3. Males and females between ages 18 and 65
4. Able to understand and comply with the requirements of the study
5. Provision of written informed consent

Exclusion Criteria:

1. Use of any antidepressant drug
2. Use of any antibiotic drug in the past 4 weeks (may be eligible to participate after a 1-month washout period)
3. Use of any sleep medication in the past 4 weeks (may be eligible to participate after a 1-month washout period)
4. Milk, yeast, or soy allergy
5. History of alcohol or substance abuse in the past 6 months
6. Daily use of probiotic product in the past 2 weeks (may be eligible to participate after a 2-week washout period)
7. Use of any type of laxative
8. Consumption of products fortified in probiotics
9. Severely suicidal
10. Experiencing psychosis or bipolar episode
11. History of epilepsy or uncontrolled seizures

Primary outcomes:
measure: Mood
timeFrame: 8 weeks
Secondary outcomes:
measure: Anxiety
timeFrame: 8 weeks
measure: Cognition
timeFrame: 8 weeks
measure: Sleep
timeFrame: 8 weeks
measure: Plasma
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Kingston
country: Canada
facility: Queen's University
state: Ontario
city: Kingston
country: Canada
facility: Providence Care - Mental Health Services
state: Ontario
Study officials:
affiliation: Queen's University
name: Roumen Milev, PhD, MD
role: PRINCIPAL_INVESTIGATOR
References: