louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01966484: Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intubating Conditions
Performance With Respiratory Exercise Device
Postoperative Myalgia
Keywords: Succinylcholine
Mivacurium
Rigid Bronchoscopy
Intubating conditions
Short Procedure
Lead sponsor: Dr. Horst Schmidt Klinik GmbH
Sponsor class: INDUSTRY
First posted: 2013-10-21
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A alternative is the application of low dose mivacurium, reversed with neostigmine. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM), patient satisfaction and the postoperative performance with respiration exercise device for these two muscle relaxants.


Eligibility criteria: Inclusion Criteria:

* age \> 18 yr
* scheduled for elective rigid bronchoscopy

Exclusion Criteria:

* known neuromuscular disease
* significant hepatic or renal dysfunction
* family history of malignant hyperthermia
* known allergy to one of the drugs used in this protocol
* pregnancy or breastfeeding

Primary outcomes:
measure: Intubating condition
timeFrame: After induction of general anaesthesia (after 3-5 minutes)
Secondary outcomes:
measure: Postoperative Myalgia
timeFrame: 72 hours after intervention
measure: postintervention performance with a expiration exercise device
timeFrame: 72 hours after intervention
Other outcomes:
measure: Patient satisfaction
timeFrame: 72 hours after intervention
Locations:
city: Wiesbaden
country: Germany
facility: Dr. Horst Schmidt Klinik GmbH
Study officials:
affiliation: Dr. Horst Schmidt Klinik GmbH 65199 Wiesbaden, Germany
name: Grietje Beck, Prof
role: STUDY_CHAIR
References:
Clinical trial NCT01846884: Specimen Stability Study
Official title: Urine Sample Processing Study:Analysis of Fresh Versus Frozen Urine Samples From Critically Ill Subjects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Kidney Injury
Lead sponsor: Astute Medical, Inc.
Sponsor class: INDUSTRY
First posted: 2013-05-06
Enrollment: 124
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Critically-ill adult subjects at risk for acute kidney injury.

Brief summary: To collect and process urine samples from critically ill subjects for use in assessing the effects of various urine sample freezing and storage conditions on biomarker test results.


Eligibility criteria: Inclusion Criteria:

1. Males and females 21 years of age or older
2. Subjects must be enrolled (first study-specific sample collection) within 24 hours of ICU admission

   * Subjects enrolled from ED or Floor must be admitted to the ICU within 24 hours of enrollment
   * Subjects enrolled in the ICU must have been admitted to the ICU or transferred into the study ICU from another ICU no more than 24 hours prior to enrollment
3. Expected to remain in the ICU for at least 48 hours after enrollment
4. Use of indwelling urinary catheter as standard care expected for at least 48 hours after enrollment
5. Subject (or authorized representative)able and willing to provide written informed consent for study participation

Exclusion Criteria:

1. Special populations including children, pregnant women, and prisoners
2. Previous renal transplantation
3. Already receiving dialysis (either acute or chronic) or in imminent need of dialysis at the time of enrollment
4. Known infection with human immunodeficiency virus (HIV) or active hepatitis (acute or chronic)
5. Subjects with a history of chronic kidney disease (CKD) without a baseline serum creatinine value (baseline within 6 months of enrollment)
6. Previously provided a urine sample and enrolled in this study

Primary outcomes:
measure: Specimen handling and stability, for example, effect of temperature on biomarker results. There are no primary clinical outcomes.
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: La Mesa
country: United States
state: California
city: Honolulu
country: United States
state: Hawaii
city: Idaho Falls
country: United States
state: Idaho
city: Las Vegas
country: United States
state: Nevada
city: Port Jefferson
country: United States
state: New York
city: Greenville
country: United States
state: North Carolina
Study officials:
References:
citation: Hoste EA, McCullough PA, Kashani K, Chawla LS, Joannidis M, Shaw AD, Feldkamp T, Uettwiller-Geiger DL, McCarthy P, Shi J, Walker MG, Kellum JA; Sapphire Investigators. Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers. Nephrol Dial Transplant. 2014 Nov;29(11):2054-61. doi: 10.1093/ndt/gfu292. Epub 2014 Sep 18.
Clinical trial NCT00046384: Study of Aripiprazole in the Treatment of Patients With Acute Symptoms of Bipolar Disorder
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Bipolar I Disorder
Lead sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.
Sponsor class: INDUSTRY
First posted: 2002-10-01
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to learn if aripiprazole is effective in the treatment of patients with acute symptoms of Bipolar Disorder.


Eligibility criteria: Patients with acute symptoms of Bipolar Disorder

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Scottsdale
country: United States
facility: Local Institution
state: Arizona
city: Little Rock
country: United States
facility: Local Institution
state: Arkansas
city: Chula Vista
country: United States
facility: Local Institution
state: California
city: Pico Rivera
country: United States
facility: Local Institution
state: California
city: Riverside
country: United States
facility: Local Institution
state: California
city: San Diego
country: United States
facility: Local Institution
state: California
city: Washington
country: United States
facility: Local Institution
state: District of Columbia
city: Winter Park
country: United States
facility: Local Institution
state: Florida
city: Staten Island
country: United States
facility: Local Institution
state: New York
city: Oklahoma City
country: United States
facility: Local Institution
state: Oklahoma
city: Nashville
country: United States
facility: Local Institution
state: Tennessee
city: Falls Church
country: United States
facility: Local Institution
state: Virginia
city: Bellevue
country: United States
facility: Local Institution
state: Washington
city: Mendoza
country: Argentina
facility: Local Institution
Study officials:
References:
Clinical trial NCT01007084: TRAUMA HELP: Healing and Analgesia With Propranolol
Official title: Phase IIB Study: TRAUMA HELP: Healing and Analgesia With Propranolol
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
Conditions: Trauma
Keywords: pain
trauma
propranolol
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
First posted: 2009-11-03
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether propranolol can decrease pain symptoms in a common subset of patients admitted to a trauma center after injury.

Detailed description: The main purpose of this pilot study is to investigate Propranolol's utility in the trauma population. Specifically, to see if it reduces pain scores post-injury.

Eligibility criteria: Inclusion Criteria:

* at least one fracture
* ages 18-60 yrs
* pain score \>= 4
* speak and read English

Exclusion Criteria:

* gunshot, stab wound, or assault
* paraplegia/quadriplegia
* pregnancy
* psychotic, suicidal, or homicidal
* hepatic, kidney failure
* clinically unstable or intubated at time of recruitment
* hyperthyroidism
* propranolol use within the last 6 months
* significant bradycardia
* cancer (except basal cell)
* peripheral vascular disease
* heart block \> 1 degree
* breastfeeding
* congestive heart failure

Primary outcomes:
measure: Daily average pain score (0-10 numeric rating pain score recorded daily from patient) after study drug initiation.
timeFrame: Study days 1, 3, 5, 7, 10, 13, 17, and 19
Secondary outcomes:
measure: Sleep quality
timeFrame: MOS Sleep Scale
measure: Anxiety symptoms
timeFrame: 7 days, 6 weeks, 3 months, 6 months
Other outcomes:
Locations:
city: Chapel Hill
country: United States
facility: University of North Carolina Trauma Center
state: North Carolina
Study officials:
affiliation: UNC Chapel Hill School of Medicine
name: Samuel M McLean, MD MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02201784: Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery
Official title: A Comparative Study Between Levobupivacaine 0.5% and Ropivacaine 0.75% in Patients Undergoing Spinal Anaesthesia for Lower Limb Orthopaedic Surgery.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Lower Limb Surgery
Keywords: Subarachnoid block
intrathecal
spinal anesthesia
isobaric
levobupivacaine
ropivacaine
Lead sponsor: Aligarh Muslim University
Sponsor class: OTHER
First posted: 2014-07-28
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the effects of two intrathecally administered drugs:0.5% levobupivacaine and0.75%Ropivacaine in spinal anesthesia

Detailed description: Bupivacaine is a highly cardiotoxic drug and also produces prolonged motor blockade.The newer drugs levobupivacaine and ropivacaine being comparatively less cardio and neurotoxic are preferred now a days.So, we conducted this prospective, randomized double blind study with an aim of comparing the efficacy and characteristics of these drugs.

Eligibility criteria: Inclusion Criteria:

1. American Society of Anesthesiologists (ASA) class I \& II patients of either sex
2. Age between 18-60 years

Exclusion Criteria:

1. Patient's refusal.
2. Patients who have contraindications to spinal anaesthesia / Local anaesthetic drugs.
3. Patients having h/o diabetes, neurological and musculoskeletal diseases.

Primary outcomes:
measure: Duration of Analgesia
timeFrame: 8 hours
Secondary outcomes:
measure: Onset of Sensory Block at T10
timeFrame: 30 minutes
measure: Median Maximum Level of Sensory Blockade
timeFrame: 8 hours
measure: Time to Maximum Cephalic Spread of Sensory Block
timeFrame: 8 hours
measure: Onset of Motor Block to Bromage3
timeFrame: 8 hours
measure: Duration of Motor Block
timeFrame: 8 hours
Other outcomes:
measure: Pulse Rate, Mean Arterial Pressure, SpO2
timeFrame: 8 hours
Locations:
city: Aligarh
country: India
facility: Jawaharlal Nehru medical college, AMU
state: Uttar Pradesh
Study officials:
affiliation: Jawaharlal Nehru Medical College, AMU,Aligarh, India
name: Manazir Athar, M.D
role: PRINCIPAL_INVESTIGATOR
affiliation: Jawaharlal Nehru Medical College, AMU, Aligarh, India
name: Syed Moied Ahmed, PhD, M.D
role: STUDY_DIRECTOR
affiliation: Jawaharlal Nehru Medical College, AMU, Aligarh, India
name: Masood H Siddiqi, M.S
role: STUDY_DIRECTOR
References:
Clinical trial NCT01289184: Air Quality Monitoring and Health Surveillance of Workers in the Photocopier Units
Official title: Air Quality Monitoring and Health Surveillance of Workers in the Photocopier Units
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Occupational Exposure
Keywords: Occupational Health Hazards
Air Pollution
Photocopiers
Other Specified Personal Exposures
History Presenting Hazards to Health
Lead sponsor: Avinashilingam Deemed University
Sponsor class: OTHER
Collaborators: name: Indian Council of Medical Research
First posted: 2011-02-03
Enrollment: 200
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: At least two years of working experience in photocopier units

Brief summary: To monitor air quality in selected photocopier units and to assess the health status of workers who are exposed to emissions from photocopiers.


Eligibility criteria: Inclusion Criteria:

* at least 2 years of exposure to photocopiers

Exclusion Criteria:

* any clinical abnormality

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Coimbatore
country: India
facility: Avinashilingam Deemed University For Women
state: Tamilnadu
Study officials:
References:
Clinical trial NCT00476684: The Effect of Radiofrequency-treatment on Patients With Facet-joint Pain in Cervical- and Lumbar-columna
Official title: The Effect of Radiofrequency-treatment on Patients With Facet-joint Pain in Cervical- and Lumbar-columna
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neck Pain
Low Back Pain
Keywords: radiofrequency
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
First posted: 2007-05-22
Enrollment: 28
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: There is conflicting evidence on whether radio-frequency neurotomy of the medial branch has a significant effect on pain in patients with chronic unilateral facet joint neck and back pain.

We will evaluate radiofrequency treatment on medial-branch of the ramus dorsalis as an effective pain treatment for patients with chronic pain originated from facet-joints in cervical and lumbar columna.


Eligibility criteria: Inclusion Criteria:

* one-sided neck and low back chronic pain
* pain durability of at least 1 year

Exclusion Criteria:

* other somatic or psychiatric disorders
* pregnancy
* stated co-morbidity
* anaesthetics intolerance
* no effect of diagnostic blockades (one or two)

Primary outcomes:
measure: reduction in self-reported pain intensity
timeFrame: up to 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Pain Clinic, University Hospital of Trondheim
Study officials:
affiliation: Norwegian University of Science and Technology
name: Petter C. Borchgrevink, prof. PhD MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Norwegian University of Science and Technology
name: Tarjei Rygnestad, Prof. PhD MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05983484: Holter Versus Skiin Garments
Official title: Non-Invasive Monitoring of Arrhythmias Electrocardiogram (ECG) Using Textile Sensors (MYANT)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiac Arrhythmia
Keywords: ECG
Wearable
Holter
Lead sponsor: Myant Medical Corp.
Sponsor class: INDUSTRY
Collaborators: name: Partners in Advanced Cardiac Evaluation
First posted: 2023-08-09
Enrollment: 53
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: adults with cardiovascular disease and/or risks justifying the need for performing an ECG Holter

Brief summary: The goal of this observational study is to compare the electrocardiogram recording from Holter monitor with textile sensors (in the form of clothing) in patients diagnosed with arrhythmia. The study aims to answer the following questions:

* Can the textile sensors provide continuous monitoring and detect arrhythmias?
* Do patients prefer to wear textile sensors instead of the Holter?

Participants that need Holter monitoring as part of their standard care will be invited to participate in the study. They will simultaneously wear both, the Holter monitor and the textile sensors for the time prescribed by their physician. Participants will also be asked to answer a questionnaire in the initial assessment and at the end of the study.


Eligibility criteria: Inclusion Criteria:

* Being addressed to the PACE cardiology clinic to perform an ECG due to a diagnosed or suspected cardiovascular disease.
* Age above 18
* Understand and speak English enough to consent and answer the study questionnaire.
* A medical need for Holter monitoring, and having a personal smartphone (iOS or Android), compatible with the Skiin app (application used to monitor the patient using the wearable device)

Exclusion Criteria:

* Pregnancy
* Implanted defibrillator or pacemaker
* Absence of garment fitting the participant's body
* Open wound or dressing (e.g. band-aid) on a body part that needs to be in contact with the Skiin electrodes
* Severe frailty such that donning or doffing the garment may cause a danger of fall.
* Sensitive skin

Primary outcomes:
measure: Difference in Usable ECG
timeFrame: Throughout the entire data collection period, that is between 1 and 14 days
measure: Difference in Heart Rate
timeFrame: Throughout the entire data collection period, that is between 1 and 14 days
measure: Difference in RR intervals
timeFrame: Throughout the entire data collection period, that is between 1 and 14 days
measure: Arrhythmic events
timeFrame: Throughout the entire data collection period, that is between 1 and 14 days
Secondary outcomes:
measure: Patient's perception
timeFrame: At the end of the study, 1 to 14 days after initiation.
Other outcomes:
Locations:
city: Newmarket
country: Canada
facility: Partners in Advanced Cardiac Evaluation (PACE) clinic
state: Ontario
Study officials:
affiliation: Partners in Advanced Cardiac Evaluation
name: Yaariv Khaykin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06511284: Nutritional Therapy in Patients With Post-extubation Dysphagia
Official title: Swallowing and Nutritional Therapy and Its Impact on Body Composition and Clinical Outcomes in Patients With Post-extubation Dysphagia
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dysphagia
Keywords: enteral nutrition
nutritional assessment
nutritional therapy
Deglutition Disorders
rehabilitation
Lead sponsor: National Institute of Respiratory Diseases, Mexico
Sponsor class: OTHER_GOV
First posted: 2024-07-19
Enrollment: 128
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized Clinical Trial
Primary purpose: TREATMENT

Brief summary: The aim of this study is to evaluate the impact of the prescription of two doses of protein on the amount in kilograms of muscle mass and on the clinical evolution (time until safe swallowing, time until removal of the feeding stoma, number of hospital readmissions, feeding stoma infections, incidence of pneumonia, functionality, number of falls, fractures and mortality) at 6 months after hospital discharge in patients with enteral nutrition due to post-extubation dysphagia.


Eligibility criteria: Inclusion Criteria:

* Patients who required invasive mechanical ventilation during their hospital stay with a diagnosis of post-extubation dysphagia diagnosed by fibroendoscopy evaluation of swallowing (FEES).
* Patients who discharged with a feeding tube.
* Patients with signed informed consent.

Exclusion Criteria:

* Patients with pre-existing dysphagia, or with neurological conditions that can cause dysphagia (e.g. multiple sclerosis, Parkinson's disease, Alzheimer's, myasthenia gravis).
* Patients with chronic kidney disease, defined as a glomerular filtration rate \<60 ml/min.
* Patients discharged with a terminal condition and/or life expectancy of less than 3 months.
* Diagnosis of HIV, upon receiving clinical follow-up by the team of specialists.

Primary outcomes:
measure: Muscle mass changes
timeFrame: From randomization to 6 months
Secondary outcomes:
measure: Swallow recovery
timeFrame: From randomization to 6 months
measure: Duration of enteral nutrition indication
timeFrame: From randomization to 6 months
measure: Feeding tube complications
timeFrame: From randomization to 6 months
measure: Muscle functionality changes
timeFrame: From randomization to 6 months
measure: Handgrip strenght changes
timeFrame: From randomization to 6 months
measure: Frailty complications
timeFrame: From randomization to 6 months
measure: Hospital readmissions associated to dysphagia complications
timeFrame: From randomization to 6 months
measure: 6-month mortality
timeFrame: From randomization to 6 months
measure: Aspiration pneumonia incidence
timeFrame: From randomization to 6 months
Other outcomes:
Locations:
city: Mexico City
country: Mexico
facility: National Institute of Respiratory Diseases
Study officials:
affiliation: National Institute of Respiratory Diseases
name: Ivan A Osuna-Padilla, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03074084: Acute Abdomen in Adults- a Prospective Study on Emergency Department Admissions
Official title: Acute Abdomen in Adults- a Prospective Study on Causes of Abdominal Pain Leading to Emergency Department Admission in Tampere University Hospital
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Abdominal Pain
Keywords: abdominal pain
adult
emergency department
electronic nose
celiac disease
Lead sponsor: Tampere University Hospital
Sponsor class: OTHER
First posted: 2017-03-08
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: the adult patients with abdominal pain admitted to the emergency department are included. One thousand patients from Tampere district will be chosen for analysis.

Brief summary: This is a non-randomized, prospective, population-based, single-center study designed to evaluate conditions resulting emergency admission in patients with abdominal pain. Furthermore, we are interested in how many patients are discharged with "non-specific abdominal pain" but later readmitted and diagnosed with a specific diagnosis.

Detailed description: 1000 adult patients with acute abdominal pain will be recruited at Tampere University Hospital Emergency department. The patients will fill in a questionaire about the symptoms and their duration. A urine sample will be collected for polyamine molecule analysis with an electronic nose. At later stage of the study, a serum sample for coeliac tests will be collected. Patient outcome will be obtained during the hospital stay, at one-month after discharge and at one year.

Eligibility criteria: Inclusion Criteria:

All adult patients with abdominal pain.

Exclusion Criteria:

Under the age of 18 years

Primary outcomes:
measure: Number of patients with specific diagnose
timeFrame: One month
Secondary outcomes:
measure: Number of patients misdiagnosed in emergency department and requiring readmission
timeFrame: One month
measure: Number of participants with treatment related adverse events
timeFrame: One month
measure: Diagnostic accuracy of polyamine molecule analysis
timeFrame: One month
measure: Number of patients with undiagnosed coeliac disease
timeFrame: One month
Other outcomes:
Locations:
city: Tampere
country: Finland
facility: Tampere University Hospital
Study officials:
affiliation: Tampere University Hospital, Finland
name: Satu-Liisa K Pauniaho, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: