Clinical trial NCT05872646: The Effect of Cognitive Functions on Upper Extremity Functionality in Parkinson's Patients
Official title: The Effect of Cognitive Functions on Upper Extremity Functionality in Parkinson's Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson
Cognitive Impairment
Upper Extremity Problem
Functional Disturbance
Keywords: Parkinson
Cognitive function
Upper extremity
Lead sponsor: Pamukkale University
Sponsor class: OTHER
First posted: 2023-05-24
Enrollment: 104
Sex: ALL
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: patient and age-gender matched healthy groups
Primary purpose: OTHER

Brief summary: Parkinson's Disease (PD), first described by James Parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. The aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with Parkinson's Disease.

Detailed description: Parkinson's Disease (PD), first described by James Parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. Involvement of nigrostriatal dopaminergic neurons is associated with the motor manifestations of the disease. The most common of these symptoms are; resting tremor, bradykinesia, rigidity and balance disorder. However, non-motor symptoms related to the involvement of nervous system structures other than the dopaminergic nigrostriatal system can be observed in PD. However, due to the predominance of motor symptoms in PD, it took many years to notice cognitive changes. Traditionally, cognitive impairments in PD have been expected to occur in the advanced stages of the disease. However, cognitive impairments in the early stages are reported in approximately 30-35% of patients. Cognitive dysfunction is defined in PD, ranging from mild impairments in certain cognitive domains to severe dementia. Cognitive impairment primarily affects executive and visuospatial functions, and memory is secondarily affected.

Executive functions are higher cognitive processes that use and modify information from many cortical sensory systems in the fore and hindbrain areas to modulate and teach behavior. The frontal cortex, especially the prefrontal cortex and its striatal connections are very important neuroanatomical regions for executive functions. The relationship between the effects of cognition and motor performance and parameters in groups such as the elderly, PD and Alzheimer's patients in which these centers are affected has been an issue that has attracted the attention of many researchers. Most of the studies have focused on the lower extremity performance of cognition. However , it has been reported that cognition has positive effects on upper extremity performance and early acquired upper extremity skills have positive effects on cognitive performance .

The aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with Parkinson's Disease.

Eligibility criteria: Inclusion Criteria:

* Having a diagnosis of Parkinson's Disease.
* Not having hearing and vision problems.
* To be able to take the commands required for the manual dexterity tests.
* Agree to participate in the study.

Exclusion Criteria:

* Having undergone musculoskeletal surgery for the upper extremity.
* Having vision and hearing problems.
* Having an additional disease that may affect cognitive tests.

Primary outcomes:
measure: Modified Hoehn Yahr Scale
timeFrame: 1 year
measure: Unified Parkinson's Disease Rating Scale
timeFrame: 1 year
measure: Parkinson's Disease Questionnaire-PDQ 39
timeFrame: 1 year
Secondary outcomes:
measure: Stroop Test
timeFrame: 1 year
measure: Wechsler Memory Scale-Revised
timeFrame: 1 year
measure: Dexterity Questionnaire-24
timeFrame: 1 year
measure: Nine Hole Peg Test
timeFrame: 1 year
Other outcomes:
Locations:
city: Denizli
country: Turkey
facility: Pamukkale Unıversity
Study officials:
affiliation: PhD student
name: DUDU ŞIMŞEK
role: STUDY_CHAIR
References: