Clinical trial NCT02823821: Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
Official title: Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: End-Stage Kidney Disease
Keywords: End-Stage Kidney Disease
Hemodialysis
Dialysate
Sodium
Cluster-randomisation
Dialysis
RESOLVE
Lead sponsor: University of Sydney
Sponsor class: OTHER
Collaborators: name: Australasian Kidney Trials Network
name: Australia & New Zealand Dialysis & Transplant Registry
name: The George Institute
name: The George Institute for Global Health, China
name: Peking University People's Hospital
name: Institute for Clinical Evaluative Sciences
name: St. Michaels Hospital
name: University Hospital Wuerzburg, Medizinische Klinik EINS
name: Malaysian Society of Nephrology
name: Malaysian Renal Registry
name: Comprehensive Clinical Trials Unit, University College London
First posted: 2016-07-06
Enrollment: 50000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.

Detailed description: RESOLVE is a pragmatic, cluster-randomised, open-label study designed to evaluate in real-world conditions the comparative effectiveness of two default dialysate sodium concentrations.

Dialysis sites will be randomised in a 1:1 ratio to a default dialysate sodium concentration of 137mmol/l or 140mmol/l. 'Default' is defined as the use of the allocated dialysate sodium for ≥ 90% of delivered dialysis sessions in the unit. All other care will be according to standard local practices as determined by the site.

Outcomes will be assessed on individual patients dialysing at those sites. Sites will be asked to consent to participation while waiver or opt-out consent will be sought for individual patients.

It is anticipated that site accrual will occur over 5-7 years with average study duration expected to be approximately 2-5 years. The actual length of the study will be end-point determined.

Eligibility criteria: The site inclusion criteria are:

* Predominantly dialyses adults (≥18 years old) receiving maintenance haemodialysis
* Rates of withdrawal within the first two years of commencing dialysis for social reasons have been less than 15% for the 2 years prior to recruitment and are not expected to increase above 15%
* Has a minimum of 10 dialysis recipients at time of randomisation
* Utilises a default dialysate sodium concentration at the time of recruitment (a substantial majority of dialysis sessions are conducted with the default dialysate sodium concentration)
* Is a self-contained unit (i.e. unit patients do not regularly rotate through another unit. Brief trips by patients to a parent or other unit do not exclude a site)
* Willing to accept randomisation to either intervention (as determined by nominated Director of Unit)
* Is not a home dialysis training or support unit. \[Sites that include both in-center/satellite dialysis patients and home patients may participate but the study procedures and assessments will only be conducted in the incenter/satellite component of the site\].

The exclusion criteria are:

* Not able to comply with data collection methods

Primary outcomes:
measure: Time to first occurrence of an event in the primary composite outcome
timeFrame: Through to study completion (estimated to occur after an average of 5 years follow up)
Secondary outcomes:
measure: Time to first occurrence of an event in the secondary composite outcome
timeFrame: Through to study completion (estimated to occur after an average of 5 years follow up)
measure: Time to first occurrence of each of the individual components of the composite outcomes.
timeFrame: Through to study completion (estimated to occur after an average of 5 years follow up)
Other outcomes:
Locations:
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
city: Auburn
country: Australia
facility: Auburn Hospital
city: Bedford Park
country: Australia
facility: Flinders Medical Centre
city: Bentleigh East
country: Australia
facility: Moorabbin Hospital
city: Birtinya
country: Australia
facility: Sunshine Coast University Private Hospital
city: Brisbane
country: Australia
facility: Princess Alexandra Hospital
city: Brisbane
country: Australia
facility: Redlands Hospital
city: Bundaberg
country: Australia
facility: Bundaberg Hospital
city: Caloundra
country: Australia
facility: Caloundra Hospital
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital
city: Canberra
country: Australia
facility: The Canberra Hospital
city: Frankston
country: Australia
facility: Peninsula Health
city: Gympie
country: Australia
facility: Gympie Hospital
city: Ipswich
country: Australia
facility: Ipswich Hospital
city: Mackay
country: Australia
facility: Mackay Base Hospital
city: Meadowbrook
country: Australia
facility: Logan Hospital
city: Melbourne
country: Australia
facility: Monash Health Community Dandenong
city: Melbourne
country: Australia
facility: Casey Hospital
city: Melbourne
country: Australia
facility: Cranbourne Integrated Care Centre
city: Nambour
country: Australia
facility: Nambour General Hospital
city: Northfield
country: Australia
facility: Hampstead Dialysis Centre
city: Pialba
country: Australia
facility: Hervey Bay Hospital
city: St Leonards
country: Australia
facility: Royal North Shore Hospital
city: Sunshine Coast
country: Australia
facility: Sunshine Coast University Hospital
city: Sydney
country: Australia
facility: Sydney Adventist Hospital
city: Sydney
country: Australia
facility: Concord Repatriation and General Hospital
city: Sydney
country: Australia
facility: Blacktown Regional Dialysis Centre
city: Sydney
country: Australia
facility: Mt Druitt Community Dialysis Centre
city: Sydney
country: Australia
facility: Nepean Hospital
city: Sydney
country: Australia
facility: Westmead Hospital
city: Woodville South
country: Australia
facility: The Queen Elizabeth Hospital
city: Brantford
country: Canada
facility: Brantford General Hospital
state: Ontario
city: Chatham
country: Canada
facility: Chatam-Kent Health Alliance
state: Ontario
city: Hamilton
country: Canada
facility: St Joseph's Healthcare
state: Ontario
city: Hanover
country: Canada
facility: Hanover District Hospital
state: Ontario
city: London
country: Canada
facility: Adam Linton Dialysis Unit - Victoria Hospital
state: Ontario
city: London
country: Canada
facility: London Health Sciences Centre
state: Ontario
city: London
country: Canada
facility: Westmount Kidney Care Centre
state: Ontario
city: Owen Sound
country: Canada
facility: Grey Bruce Health Services
state: Ontario
city: Sarnia
country: Canada
facility: Bluewater Hospital
state: Ontario
city: Stratford
country: Canada
facility: Huron Perth Hospital Partnership
state: Ontario
city: Tillsonburg
country: Canada
facility: Tillsonburg District Memorial Hospital
state: Ontario
city: Woodstock
country: Canada
facility: Woodstock General Hospital
state: Ontario
city: Hamilton
country: Canada
facility: Stoney Creek
city: Kingston
country: Canada
facility: Belleville
city: Kingston
country: Canada
facility: Brockville
city: Kingston
country: Canada
facility: Kingston General
city: Kingston
country: Canada
facility: Napanee
city: Kingston
country: Canada
facility: Perth and Smith Falls
city: Kingston
country: Canada
facility: Picton
city: Toronto
country: Canada
facility: St. Michael's Hospital
city: Albstadt
country: Germany
facility: Nephrologisches Zentrum Albstadt
city: Berlin
country: Germany
facility: Praxis für Nierenkrankheiten Berlin Hellersdorf
city: Bochum
country: Germany
facility: Dialyse am Kortumpark Bochum
city: Darmstadt
country: Germany
facility: Dialysezentrum Darmstadt
city: Elsenfeld
country: Germany
facility: Dialysezentrum Elsenfeld
city: Hechingen
country: Germany
facility: Nephrologisches Zentrum Hechingen
city: Homburg
country: Germany
facility: Arbeitsgemeinschaft Heimdialyse Saar e.V.
city: Langen
country: Germany
facility: Dialysezentrum Langen
city: Lichtenfels
country: Germany
facility: KfH Nierenzentrum Lichtenfels
city: Mainz
country: Germany
facility: Universitätsmedizin Mainz, Dialysestation 605-5E
city: Munich
country: Germany
facility: KfH Nierenzentrum München Schwabing
city: Schweinfurt
country: Germany
facility: Dialysezentrum Schweinfurt
city: Siegburg
country: Germany
facility: Dialysezentrum Siegburg
city: Unna
country: Germany
facility: Nephrologie - Dialyse - Christliches Klinikum Unna
city: Villingen-Schwenningen
country: Germany
facility: Nephrologisches Zentrum Villingen-Schwenningen -Tuttlingen
city: Öhringen
country: Germany
facility: UBAG Öhringen
city: Chirala
country: India
facility: Area Hospital, Kothapeta Road,Chirala, Andhra Pradesh
state: Andhra Pradesh
city: Gudur
country: India
facility: Medical Superintendent Government Hospital
state: Andhra Pradesh
city: Guntur
country: India
facility: Government General Hospital
state: Andhra Pradesh
city: Hindupur PPP
country: India
facility: Medical Superintendent District Hospital
state: Andhra Pradesh
city: Kanigiri
country: India
facility: Government Area Hospital, Kanigiri, Andhra Pradesh
state: Andhra Pradesh
city: Kurnool
country: India
facility: Government General Hospital
state: Andhra Pradesh
city: Kākināda
country: India
facility: Government Hospital
state: Andhra Pradesh
city: Machilipatnam
country: India
facility: Government Hospital, Machilipatnam PPP, Andhra Pradesh
state: Andhra Pradesh
city: Markapur
country: India
facility: Government Area Hospital
state: Andhra Pradesh
city: Nandyal
country: India
facility: Government Hospital
state: Andhra Pradesh
city: Narsipatnam
country: India
facility: Area Hospital
state: Andhra Pradesh
city: Palakonda, Srikakulam District
country: India
facility: Government Area Hospital
state: Andhra Pradesh
city: Palasa
country: India
facility: CHC Government Hospital
state: Andhra Pradesh
city: Parvathipuram
country: India
facility: Government Area Hospital
state: Andhra Pradesh
city: Proddatur
country: India
facility: Government Hospital
state: Andhra Pradesh
city: Rajahmundry
country: India
facility: Government Hospital
state: Andhra Pradesh
city: Sompeta
country: India
facility: CHC Hospital, Sompeta, Andhra Pradesh
state: Andhra Pradesh
city: Tadepalligudem
country: India
facility: Greater Kailash Hospital
state: Andhra Pradesh
city: Tirupati
country: India
facility: Manasa Kidney Foundation
state: Andhra Pradesh
city: Vijayavada
country: India
facility: Government General Hospital, Vijayavada PPP, Andhra Pradesh
state: Andhra Pradesh
city: Visakhapatnam
country: India
facility: King George Government Hospital
state: Andhra Pradesh
city: Srikakulam
country: India
facility: Rajiv Gandhi Institute of Medical Sciences, Srikakulam PPP, Andhra
state: Andhra
city: Patna
country: India
facility: Ford Hospital, Khemnichak, Patna
state: Bihar
city: Patna
country: India
facility: Janak Dulari Hospital, Hanuman Nagar
state: Bihar
city: Kilpauk
country: India
facility: Aysha Hospital
state: Chennai
city: Kolathur
country: India
facility: Retteri Sri Kumaran Health Centre
state: Chennai
city: Ambāla
country: India
facility: Leelawati Hospital
state: Haryana
city: Old Palasia
country: India
facility: Greater Kailash Hospital
state: Indore
city: Adityapur
country: India
facility: ESI Hospital
state: Jharkand
city: Bokaro
country: India
facility: K.M Memorial Hospital and Research Centre
state: Jharkhand
city: Dhanbad
country: India
facility: Asarfi Hospital
state: Jharkhand
city: Ranchi
country: India
facility: Bhagwan Mahavir Medical Superspeciality Hospital
state: Jharkhand
city: Ranchi
country: India
facility: Guru Nanak Hospital and Research Centre
state: Jharkhand
city: Bengaluru
country: India
facility: Koshys Hospital, Ramamurthy Nagar
state: Karnataka
city: Bengaluru
country: India
facility: Nephroplus Basaveshwaranagar
state: Karnataka
city: Hubli
country: India
facility: Fortis Suchirayu Hospital
state: Karnataka
city: Kothagudem
country: India
facility: Main Hospital, SCCL
state: Khammam
city: Indore
country: India
facility: Vishesh Hospital Pvt. Ltd, Geeta Bhawan Chouraha
state: Madhya Pradesh
city: Mumbai
country: India
facility: Hitwardhak Mandal Hospital
state: Maharashtra
city: Pune
country: India
facility: Lokmanya Hospital
state: Maharashtra
city: Thāne
country: India
facility: Chirayu Hospital
state: Maharashtra
city: Borivali West
country: India
facility: Nephroplus Borivali Standalone
state: Mumbai
city: Borivali West
country: India
facility: Bharat Baug
state: Mumbai
city: Balasore
country: India
facility: Jyothi Hospital
state: Odisha
city: Bhubaneswar
country: India
facility: Kar Clinic & Hospital Pvt. Ltd.
state: Odisha
city: Bhubaneswar
country: India
facility: Neelachal Hospital, Kharvel Nagar
state: Odisha
city: Ludhiāna
country: India
facility: Satguru Partap Singh Apollo Hospitals
state: Punjab
city: Coimbatore
country: India
facility: KG Hospital
state: Tamil Nadu
city: Neyveli
country: India
facility: Sudha Hospital, Vadalur
state: Tamil Nadu
city: Chennai
country: India
facility: Deepam Hospitals, Pallavaram
state: Tamilnadu
city: Neyveli
country: India
facility: Neyveli Lignite Corporation Hospital
state: Tamilnadu
city: Hyderabad
country: India
facility: Citizens Specialty Hospital
state: Telangana
city: Hyderabad
country: India
facility: ESI Multi-Specialty Hospital
state: Telangana
city: Hyderabad
country: India
facility: Vintage Plaza Nephroplus, Road no. 10, Banjara Hills
state: Telangana
city: Khammam
country: India
facility: Government Hospital
state: Telangana
city: Nalgonda
country: India
facility: Suraksha Multispecialty Hospital
state: Telangana
city: Secunderabad
country: India
facility: Nephroplus Standalone Dialysis Center, Easy Marredpally
state: Telangana
city: Kanpur
country: India
facility: Madhuraj Hospital
state: Uttar Pradesh
city: Lucknow
country: India
facility: Ajanta Hospital
state: Uttar Pradesh
city: Noida
country: India
facility: Surbhi Hospital Pvt. Ltd, Sector 35
state: Uttar Pradish
city: Kolkata
country: India
facility: Health Point Hospital, Prannth Pandit Street
state: West Bengal
city: Tamluk
country: India
facility: Minimal Access Surgery Clinic Pvt Ltd
state: West Bengal
city: Uttar Mechgram
country: India
facility: Baroma Sirona Hospital
state: West Bengal
city: Ampang
country: Malaysia
facility: Hospital Ampang
city: Batu Pahat
country: Malaysia
facility: Hospital Sultanah Nora Ismail
city: Beaufort
country: Malaysia
facility: Hospital Beaufort
city: George Town
country: Malaysia
facility: Hospital Pulau Pinang
city: Ipoh
country: Malaysia
facility: Pusat Dialisis NKF- Yayasan Dialisis Pendidikan Akhlak Perak
city: Johor Bahru
country: Malaysia
facility: Hospital Sultan Ismail
city: Johor Bahru
country: Malaysia
facility: Hospital Sultanah Aminah
city: Kajang
country: Malaysia
facility: Hospital Kajang
city: Kajang
country: Malaysia
facility: Hospital Serdang
city: Kangar
country: Malaysia
facility: Hospital Tuanku Fauziah
city: Kangar
country: Malaysia
facility: Pusat Rawatan Dialisis Tuanku Syed Putra - NKF
city: Klang
country: Malaysia
facility: Hospital Tengku Ampuan Rahimah
city: Klang
country: Malaysia
facility: Pusat Daillisis NKF - Kelab Apex
city: Kota Bharu
country: Malaysia
facility: Hospital Raja Perempuan Zainab II
city: Kota Kinabalu
country: Malaysia
facility: Hospital Likas
city: Kota Kinabalu
country: Malaysia
facility: Hospital Queen Elizabeth II
city: Kuala Kangsar
country: Malaysia
facility: Hospital Kuala Kangsar
city: Kuala Lipis
country: Malaysia
facility: Hospital Kuala Lipis
city: Kuala Lumpur
country: Malaysia
facility: Hospital Kuala Lumpur
city: Kuala Lumpur
country: Malaysia
facility: Pusat Dialisis NKF-Fungates Superflow
city: Kuala Lumpur
country: Malaysia
facility: Pusat Dialisis NKF-Nanyang
city: Kuala Lumpur
country: Malaysia
facility: Universiti Kebangsaan Malaysia Medical Centre
city: Kuala Lumpur
country: Malaysia
facility: University of Malaya Medical Centre
city: Kuantan
country: Malaysia
facility: Hospital Tengku Ampuan Afzan
city: Kudat
country: Malaysia
facility: Hospital Kudat
city: Kulim
country: Malaysia
facility: Hospital Kulim
city: Labuan
country: Malaysia
facility: Hospital Labuan
city: Langgar
country: Malaysia
facility: Hospital Sultanah Bahiyah
city: Lenggong
country: Malaysia
facility: Haemodialysis Unit Klinik Kesihatan Lenggong
city: Malaka
country: Malaysia
facility: Pusat Hemodialisis Komuniti Cheng
city: Muar
country: Malaysia
facility: Hospital Pakar Sultanah Fatimah
city: Permatang Pauh
country: Malaysia
facility: Hospital Seberang Jaya
city: Petaling Jaya
country: Malaysia
facility: Pusat Dialisis NKF - Chempaka
city: Shah Alam
country: Malaysia
facility: Hospital Shah Alam
city: Shah Alam
country: Malaysia
facility: Universiti Teknologi Mara
city: Sungai Petani
country: Malaysia
facility: Hospital Sultan Abdul Halim
city: Sungai Siput
country: Malaysia
facility: Hospital Sungai Siput
city: Tambunan
country: Malaysia
facility: Hospital Tambunan
city: Temerluh
country: Malaysia
facility: Hospital Sultan Haji Ahmad Shah
city: Altrincham
country: United Kingdom
facility: Altrincham General Hospital Dialysis Unit
city: Ashton-under-Lyne
country: United Kingdom
facility: Tameside Renal Dialysis Unit
city: Barnet
country: United Kingdom
facility: Barnet Satellite Unit
city: Barnsley
country: United Kingdom
facility: Barnsley Dialysis Unit
city: Bath
country: United Kingdom
facility: Bath Dialysis Unit
city: Bedford
country: United Kingdom
facility: Bedford Renal Unit
city: Bexhill-on-Sea
country: United Kingdom
facility: Bexhill Dialysis Unit
city: Blackley
country: United Kingdom
facility: Hexagon Towers Dialysis Unit
city: Bolton
country: United Kingdom
facility: Bolton Kidney Care Centre
city: Bradford
country: United Kingdom
facility: St Luke's Hospital Renal Ward
city: Bridgwater
country: United Kingdom
facility: Bridgwater Dialysis Unit
city: Brighton
country: United Kingdom
facility: Brighton Sussex Kidney Unit
city: Bristol
country: United Kingdom
facility: Cossham Dialysis Unit
city: Bristol
country: United Kingdom
facility: South Bristol Dialysis Unit
city: Bromley
country: United Kingdom
facility: Bromley Dialysis Unit
city: Broomfield
country: United Kingdom
facility: Broomfield Hospital
city: Cannock
country: United Kingdom
facility: Cannock Haemodialysis Unit
city: Chesterfield
country: United Kingdom
facility: Chesterfield Dialysis Unit
city: Clacton-on-Sea
country: United Kingdom
facility: Clacton (Diaverum)
city: Colchester
country: United Kingdom
facility: Colchester (Diaverum)
city: Coventry
country: United Kingdom
facility: Clay Lane
city: Coventry
country: United Kingdom
facility: University Hospitals Coventry & Warwickshire Main Unit
city: Crawley
country: United Kingdom
facility: Crawley Dialysis Unit
city: Crewe
country: United Kingdom
facility: Leighton
city: Cromer
country: United Kingdom
facility: Cromer Hospital Dialysis Unit
city: Darlington
country: United Kingdom
facility: Darlington Dialysis Unit
city: Dartford
country: United Kingdom
facility: Dartford Dialysis Unit
city: Dover
country: United Kingdom
facility: Dover Renal Unit
city: Edgware
country: United Kingdom
facility: Edgware Satellite Unit
city: Epsom
country: United Kingdom
facility: Epsom Dialysis Unit
city: Exeter
country: United Kingdom
facility: Heavitree
city: Farnborough
country: United Kingdom
facility: Farnborough Dialysis Unit
city: Gloucester
country: United Kingdom
facility: Cotswold Dialysis Centre
city: Gloucester
country: United Kingdom
facility: Severn
city: Great Yarmouth
country: United Kingdom
facility: James Paget Renal Unit
city: Grimsby
country: United Kingdom
facility: Grimsby Renal Unit
city: Harlow
country: United Kingdom
facility: Harlow Renal Unit
city: Hayes
country: United Kingdom
facility: Hayes Hospital
city: Honiton
country: United Kingdom
facility: Honiton
city: Houghton Regis
country: United Kingdom
facility: Chiltern Renal Unit
city: Hull
country: United Kingdom
facility: Fresenius Hull Dialysis Unit
city: Isleworth
country: United Kingdom
facility: West Middlesex
city: Kingston
country: United Kingdom
facility: Kingston Satellite Dialysis Unit
city: London
country: United Kingdom
facility: Collierswood Dialysis Unit
city: London
country: United Kingdom
facility: King George Hospital
city: London
country: United Kingdom
facility: Mary Rankin Satellite Unit
city: London
country: United Kingdom
facility: North Wandsworth Dialysis Unit
city: London
country: United Kingdom
facility: Royal London Hospital
city: London
country: United Kingdom
facility: Whipps Cross Hospital
city: Ludlow
country: United Kingdom
facility: Ludlow Dialysis Unit
city: Macclesfield
country: United Kingdom
facility: Macclesfield District General Hospital
city: Manchester
country: United Kingdom
facility: Manchester Royal Infirmary Renal Dialysis Unit
city: Manchester
country: United Kingdom
facility: Octagon Renal Satellite
city: Margate
country: United Kingdom
facility: Margate Renal Unit
city: Middlesbrough
country: United Kingdom
facility: James Cook
city: Middlesbrough
country: United Kingdom
facility: North Ormesby
city: North Yorkshire
country: United Kingdom
facility: Harrogate
city: Northallerton
country: United Kingdom
facility: Friarage Hospital
city: Nuneaton
country: United Kingdom
facility: Lucy Deane (George Eliot)
city: Oldham
country: United Kingdom
facility: Oldham Dialysis Unit
city: Plaistow
country: United Kingdom
facility: Newham Hospital
city: Polegate
country: United Kingdom
facility: Eastbourne (Polegate) Dialysis Unit
city: Rochdale
country: United Kingdom
facility: Rochdale Dialysis Unit
city: Romford
country: United Kingdom
facility: Queen's Hospital
city: Rotherham
country: United Kingdom
facility: Rotherham Dialysis Unit
city: Rugby
country: United Kingdom
facility: St Cross (Ash Unit)
city: Salford
country: United Kingdom
facility: Salford Renal Unit
city: Scarborough
country: United Kingdom
facility: Scarborough
city: Scunthorpe
country: United Kingdom
facility: Scunthorpe Dialysis Centre
city: Sheffield
country: United Kingdom
facility: Peter Moorhead Unit
city: Sheffield
country: United Kingdom
facility: Renal G Floor
city: Sheffield
country: United Kingdom
facility: Sheffield Dialysis Unit
city: Shrewsbury
country: United Kingdom
facility: Shrewsbury Renal Unit
city: Smethwick
country: United Kingdom
facility: Smethwick Dialysis Centre
city: St Albans
country: United Kingdom
facility: St Albans Dialysis Unit
city: Stafford
country: United Kingdom
facility: County Hospital
city: Stevenage
country: United Kingdom
facility: Lister Renal Unit
city: Stockport
country: United Kingdom
facility: Stockport NHS Dialysis Unit
city: Stockton-on-Tees
country: United Kingdom
facility: North Tees
city: Stoke-on-Trent
country: United Kingdom
facility: Royal Stoke
city: Stratford-upon-Avon
country: United Kingdom
facility: Stratford Dialysis Centre
city: Sutton
country: United Kingdom
facility: St. Helier Dialysis Unit
city: Sutton
country: United Kingdom
facility: Sutton Dialysis Unit
city: Taunton
country: United Kingdom
facility: Taunton Dialysis Centre
city: Telford
country: United Kingdom
facility: Hollinswood House Renal Unit
city: Thornton Heath
country: United Kingdom
facility: Croydon Dialysis Unit
city: Torquay
country: United Kingdom
facility: South Devon Satellite Kidney Unit
city: Tottenham
country: United Kingdom
facility: Tottenham Hale Satellite Unit
city: Wigan
country: United Kingdom
facility: Wigan Renal Unit
city: Willesborough
country: United Kingdom
facility: Ashford Renal Unit
city: Wolverhampton
country: United Kingdom
facility: Pond Lane Dialysis Unit
city: Woolwich
country: United Kingdom
facility: Woolwich Dialysis Unit
city: Worthing
country: United Kingdom
facility: Worthing Dialysis Unit
city: York
country: United Kingdom
facility: Easingwold
city: York
country: United Kingdom
facility: York Hospital
Study officials:
affiliation: The University of Sydney, NHMRC Clinical Trials Centre
name: Meg Jardine
role: STUDY_DIRECTOR
affiliation: The University of Queensland
name: Carmel Hawley
role: STUDY_CHAIR
affiliation: The George Institute India
name: Vivekanand Jha
role: STUDY_CHAIR
affiliation: Peking University People's Hospital
name: Zuo Li
role: STUDY_CHAIR
affiliation: Kuala Lumpur General Hospital
name: Sunita Bavanandan
role: STUDY_CHAIR
affiliation: Comprehensive Clinical Trials Unit, University College London
name: David Wheeler
role: STUDY_CHAIR
affiliation: INSERM Clinical Investigation Centre
name: Patrick Rossignol
role: STUDY_CHAIR
affiliation: McMaster University
name: Mike Walsh
role: STUDY_CHAIR
affiliation: University of New South Wales
name: Vlado Perkovic
role: STUDY_CHAIR
affiliation: University Hospital Wuerzburg
name: Christoph Wanner
role: STUDY_CHAIR
affiliation: University Hospital Wuerzburg
name: Jule Pinter
role: PRINCIPAL_INVESTIGATOR
References:
citation: See EJ, Polkinghorne KR. Volume management in haemodialysis patients. Curr Opin Nephrol Hypertens. 2020 Nov;29(6):663-670. doi: 10.1097/MNH.0000000000000642.