louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00435890: Triage Liaison Physician - Evaluation of a Novel Approach to Address Emergency Department Overcrowding
Official title: Randomized Controlled Trial of a Liaison Physician at the Triage Desk to Reduce Emergency Department Overcrowding and Improve Patient Flow.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Acute Illness
Keywords: ED Overcrowding
Length of stay
Emergency triage
triage
Lead sponsor: University of Alberta
Sponsor class: OTHER
First posted: 2007-02-16
Enrollment: 5718
Sex: ALL
Minimum age (years): 17
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This randomized controlled trial will introduce a triage liaison physician (TLP) into the University of Alberta Hospital Emergency Department (ED) and assess the influence on patients who leave without being seen, ED length of stay, and other ED Overcrowding outcomes.

Detailed description: ED Overcrowding is a significant cause of delayed care, patient dissatisfaction, and poor outcomes in North American EDs. This intervention has not been widely studied; however, it represents an opportunity for improving patient flows in EDs.

Eligibility criteria: Inclusion Criteria:

* Only adult patients (\> 17 years of age) presenting to the University of Alberta Hospital Emergency Department (UAH ED), during the study interval will be included in the evaluation.

Exclusion Criteria:

* Direct admits/Pediatric patients.

Primary outcomes:
measure: Median patient length of stay
timeFrame: while in the Emergency Department
Secondary outcomes:
measure: Left without being seen
timeFrame: while in the Emergency Department
measure: ambulance turnaround times
timeFrame: while in the Emergency Department
measure: satisfaction (physicians and nurses)
timeFrame: following their Emergency Department shift
measure: TLP activity
timeFrame: while in the Emergency Department
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: University of Alberta Hospital
state: Alberta
Study officials:
affiliation: University of Alberta
name: Brian H Rowe, MD
role: STUDY_DIRECTOR
References:
citation: Holroyd BR, Bullard MJ, Latoszek K, Gordon D, Allen S, Tam S, Blitz S, Yoon P, Rowe BH. Impact of a triage liaison physician on emergency department overcrowding and throughput: a randomized controlled trial. Acad Emerg Med. 2007 Aug;14(8):702-8. doi: 10.1197/j.aem.2007.04.018.
Clinical trial NCT04190290: Anorexia Nervosa Inpatient Physiotherapy Adapted Program
Official title: Efficacy of Adapted Program of Physiotherapy in Hospitalized Person by Anorexia Nervosa With Several Undernutrition
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Anorexia Nervosa
Keywords: Anorexia nervosa
Muscle strength
Peak-expiratory-flow
Quality of life
Lead sponsor: Universidad de Murcia
Sponsor class: OTHER
First posted: 2019-12-09
Enrollment: 26
Sex: FEMALE
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Quasi experimental prospective study
Primary purpose: TREATMENT

Brief summary: Anorexia nervosa (AN) is a psychiatric pathology with several somatics consequences that increase the vital risk. The prevalence in AN is between 0.9-3% and AN has the most elevated mortality in the psychiatric pathologies (10% in the hospitalized patients).

The collateral effects by several undernourishment has been studied but the autonomy and muscle strength research is insufficient.

Physiotherapy research study body image, basic body awareness therapy, relaxation and quality of life.

Detailed description: OBJETIVE: Develop a physiotherapy program to increase muscle strength and quality of life in anorexia nervosa hospitalized patients.

METHOD: 4 weeks of adapted exercises (3 days/week) in anorexia nervosa patients with body max index under 16 in interventional group.

And evaluation program once a week in interventional group and control group.

Eligibility criteria: Inclusion Criteria:

* Women
* Hospitalized
* Anorexia nervosa
* Body mass index (kg/m2) \< 16

Exclusion Criteria:

* Men

Primary outcomes:
measure: Strength
timeFrame: 4 weeks
measure: Resistance
timeFrame: 4 weeks
measure: Life
timeFrame: 4 weeks
measure: Behavior
timeFrame: 4 weeks
Secondary outcomes:
measure: Others
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Murcia
country: Spain
facility: University Hospital Reina Sofía
Study officials:
References:
Clinical trial NCT01683890: Study on Bladder and Sexual Function Change After Simple Hysterectomy
Official title: Incidence and Pattern of Overactive Bladder Symptoms Occurring After Hysterectomy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Benign Uterine Disease
Keywords: Bladder symptoms
Sexual function
Quality of life
Simple hysterectomy
Lead sponsor: Asan Medical Center
Sponsor class: OTHER
Collaborators: name: Astellas Pharma Inc
First posted: 2012-09-12
Enrollment: 300
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patinets who undergo simple hysterectomy due to benign uterine disease at university hospital

Brief summary: To evaluate the incidence and pattern of bladder symptoms and sexual function change occuring after simple hysterectomy and to analyze the influence of bladder symptoms and sexual function change on quality of life of patients.


Eligibility criteria: Inclusion Criteria:

* Patients who is planed to undergo simple hysterectomy due to benign uterine disease

  1. Uterine leiomyoma
  2. Uterine adenomyosis
  3. Endometrial hyperplasia
  4. Cervical intraepithelial neoplasia (including carcinoma in situ, FIGO stage IA1 cancer)
  5. Dysfunctional uterine bleeding
  6. Other benign uterine disease requiring hysterectomy

Exclusion Criteria:

* Patients who are taking medication for overactive bladder
* Patients who underwent incontinence surgery due to urinary incontinence
* Acute or chronic infectious disease of urinary tract
* Neurologic disease causing urinary abnormality
* Previous pelvic radiation therapy
* Patients who are undergoing incontinence surgery with hysterectomy
* Pregnant woman

Primary outcomes:
measure: Incidence of bladder symptoms
timeFrame: within 6 months after surgery
Secondary outcomes:
measure: Pattern change of bladder symptoms after surgery
timeFrame: Baseline and within 6 months after surgery
measure: Sexual function change
timeFrame: Baseline and within 6 months after surgery
measure: Quality of life
timeFrame: within 6 months aftr surgery
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center
Study officials:
affiliation: Asan Medical Center
name: Hee-Dong Chae, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00090090: Elsamitrucin (SPI 28090) for Relapsed or Refractory Non-Hodgkin's Lymphoma
Official title: A Multi-Center, Open-Label, Non-Randomized Phase II Study of Elsamitrucin (SPI 28090) In Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Mantle Cell Lymphoma
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Lead sponsor: Spectrum Pharmaceuticals, Inc
Sponsor class: INDUSTRY
First posted: 2004-08-25
Enrollment: 114
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To determine the safety and efficacy of elsamitrucin in patients with relapsed or refractory non-Hodgkin's lymphoma (NHL). To determine if elsamitrucin is efficacious in a particular pathologic NHL subtype(s).


Eligibility criteria: Inclusion Criteria:

* Relapsed or Refractory mantle cell lymphoma and/or CLL/SLL except Burkitt's, Burkitt's like or HIV-associated lymphoma
* at least one prior cytotoxic chemotherapy regimens
* measurable disease
* adequate bone marrow, liver and kidney function
* ECOG PS 0-2

Exclusion Criteria:

* prior treatment with elsamitrucin
* prior chemo, antibody or radiotherapy for NHL within 28 days prior to start to treatment
* HIV positive or known AIDS syndrome
* uncontrolled medical disease or psychiatric condition/s

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Berkeley
country: United States
facility: Alta Bates Cancer Center
state: California
city: Burbank
country: United States
facility: Providence Saint Joseph Medical Center
state: California
city: Los Angeles
country: United States
facility: USC Norris Cancer Center
state: California
city: Los Angeles
country: United States
facility: Tower Hematology Oncology Medical Group
state: California
city: Mission Hills
country: United States
facility: North Valley Hematology Oncology Medical Group
state: California
city: Rancho Mirage
country: United States
facility: Cancer and Blood Institute Medical Group
state: California
city: Manhasset
country: United States
facility: North Shores University Hospital
state: New York
Study officials:
References:
citation: Allen SL, Schacter LP, Lichtman SM, Bukowski R, Fusco D, Hensley M, O'Dwyer P, Mittelman A, Rosenbloom B, Huybensz S. Phase II study of elsamitrucin (BMY-28090) for the treatment of patients with refractory/relapsed non-Hodgkin's lymphoma. Invest New Drugs. 1996;14(2):213-7. doi: 10.1007/BF00210793.
Clinical trial NCT02755090: Nitrous Oxide Versus Intravenous Sedation for Anesthesia
Official title: Nitrous Oxide Versus Intravenous Sedation for Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pregnancy Termination in Second Trimester
Keywords: nitrous
pain
Lead sponsor: University of New Mexico
Sponsor class: OTHER
Collaborators: name: Society of Family Planning
name: University of Colorado, Denver
First posted: 2016-04-28
Enrollment: 39
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This study is a multi-site, double-blinded, randomized, non-inferiority clinical trial of inhaled nitrous oxide with oxygen (N2O/O2) versus intravenous (IV) sedation, with fentanyl and midazolam, for pain management in adult women having a pregnancy termination procedure between 12 and 16 weeks gestational age.

Detailed description: This study will evaluate whether nitrous oxide is a feasible and acceptable alternative to IV sedation for pain management during early second trimester D\&E. Primary endpoints will include maximum procedural pain using the visual analog scale (VAS) as well as satisfaction with anesthesia using the Iowa Satisfaction with Anesthesia Scale.

Eligibility criteria: Inclusion Criteria:

* 18 years old or older
* pregnancy termination at gestational age of 12-16 weeks
* able to read and understand either English or Spanish
* able to obtain reliable post-procedure transportation

Exclusion Criteria:

* contraindications to outpatient pregnancy termination
* contraindications to nitrous oxide use (such as pernicious anemia, current treatment with bleomycin chemotherapy, active upper respiratory illness, or COPD)
* intrauterine fetal demise
* chronic narcotic use
* known adverse reaction to nitrous oxide, Fentanyl, or Versed

Primary outcomes:
measure: Visual Analog Scale (VAS) Score for Maximum Procedural Pain
timeFrame: Assessed immediately following completion of the procedure (as defined as removal of the speculum)
measure: Satisfaction With Anesthesia (Iowa Satisfaction With Anesthesia Scale [ISAS])
timeFrame: Assessed 30 minutes after procedure completion.
Secondary outcomes:
Other outcomes:
Locations:
city: Denver
country: United States
facility: University of Colorado
state: Colorado
city: Albuquerque
country: United States
facility: University of New Mexico Health Sciences Center
state: New Mexico
Study officials:
affiliation: University of New Mexico Health Sciences Center
name: Rameet Singh, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Thaxton L, Pitotti J, Espey E, Teal S, Sheeder J, Singh RH. Nitrous Oxide Compared With Intravenous Sedation for Second-Trimester Abortion: A Randomized Controlled Trial. Obstet Gynecol. 2018 Nov;132(5):1192-1197. doi: 10.1097/AOG.0000000000002915.
Clinical trial NCT01737190: PEEP Guided by Esophageal Balloon Measurement and Its Effect on Recruitment Maneuver
Official title: PEEP Guided by Esophageal Balloon Measurement and Its Effect on Recruitment Maneuver
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: ARDS
Keywords: esophageal pressure
ARDSnet protocol
Lead sponsor: Wolfson Medical Center
Sponsor class: OTHER_GOV
First posted: 2012-11-29
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The aim of the study is to examine the effects of two different levels of PEEP on subsequent standard recruitment maneuver.

Detailed description: In this study we will examine the effects of two levels of PEEP on subsequent recruitment maneuver. In the first group a recruitment maneuver will be performed in patients who are ventilated with PEEP level set according to the ARDS network algorithm.

Patients will then be crossed over to a study arm where another recruitment maneuver will be performed while PEEP is adjusted according to esophageal pressure measurements.

Eligibility criteria: Inclusion Criteria:

20 Man and women older than 18 years will be recruited.

Patients with acute respiratory failure of any cause who are mechanically ventilated according to the ARDS network recommendations will be considered for inclusion to the study.

To be included in the study a prerequisite of high peak Inspiratory pressure (plateau pressure of 25 to 30 cmH2O) has to be present, and at least one of the following four severity inclusion criteria has to be met.

1 - Low Total Respiratory system compliance (CT), defined as less than 50ml/cmH2O. 2 - PaO2 /FIO2 ratio of less than 300. 3 - Need for a PEEP greater than 10 cmH2O to maintain SaO2 of \> 90%. 4 - PCO2 over 60 mmHg, or PH less than 7.2 that is attributed to respiratory acidosis.

Exclusion Criteria:

Patients with any of the following will be excluded from the study. Previous lung or chest wall surgery, previous esophageal surgery, known Achalasia or any other esophageal motility or spasm disorder, presence of chest thoracostomy tube, and any significant chest wall abnormality such as kyphoskoliosis.

Primary outcomes:
measure: oxygenation
timeFrame: 4 hours
Secondary outcomes:
measure: lung compliance
timeFrame: 4 hours
Other outcomes:
Locations:
city: Holon
country: Israel
facility: E. Wolfson MC
Study officials:
affiliation: Wolfson MC
name: Arie Soroksky, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00888290: Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects
Official title: Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Chronic Kidney Disease
Keywords: metabolic acidosis
chronic kidney disease
Estimated GFR 15-45
Lead sponsor: Albert Einstein College of Medicine
Sponsor class: OTHER
First posted: 2009-04-27
Enrollment: 20
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: This study will enroll 25 patients with kidney disease to evaluate the effects of different doses of sodium bicarbonate (baking soda) on levels of bicarbonate in the blood, kidney function and muscle strength. The investigators will also evaluate safety and tolerability of different doses.

Detailed description: This study enrolled 20 patient to evaluate the effects of different doses of sodium bicarbonate. We will test serum bicarbonate levels, potassium levels and muscle function.

Eligibility criteria: Inclusion Criteria:

* Estimated GFR \< 45 ml/min/1.73m2 and \>15 ml/min/1.73 m2 determined by abbreviated 4 variable modification MDRD equation
* Age \>21

Exclusion Criteria:

* Previous chronic treatment with alkali (including sodium bicarbonate, calcium carbonate or baking soda)
* Bicarbonate level \<20 or \>25 mEq/L
* Decompensated heart failure
* Systolic blood pressure \>160 mm/Hg
* Moderate or greater lower extremity edema
* Initiation of ESRD treatment planned within 6 months
* Kidney transplantation
* Treatment with immunosuppressives within the last 3 months

Primary outcomes:
measure: Serum Bicarbonate Levels
timeFrame: 8 weeks
Secondary outcomes:
measure: Muscle Strength as Measured by sit-to Stand Test
timeFrame: 8 weeks
measure: Systolic Blood Pressure
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Bronx
country: United States
facility: Albert Einstein College of Medicine/ Montefiore Medical Center
state: New York
Study officials:
affiliation: Albert Einstein College of Medicine
name: Thomas Hostetter, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chen W, Melamed ML, Hostetter TH, Bauer C, Raff AC, Almudevar AL, Lalonde A, Messing S, Abramowitz MK. Effect of oral sodium bicarbonate on fibroblast growth factor-23 in patients with chronic kidney disease: a pilot study. BMC Nephrol. 2016 Aug 5;17(1):114. doi: 10.1186/s12882-016-0331-6.
citation: Abramowitz MK, Melamed ML, Bauer C, Raff AC, Hostetter TH. Effects of oral sodium bicarbonate in patients with CKD. Clin J Am Soc Nephrol. 2013 May;8(5):714-20. doi: 10.2215/CJN.08340812. Epub 2013 Feb 7.
Clinical trial NCT03646890: Epidemiology and Clinical Features of Uveitis in a Tertiary Referral
Official title: Epidemiology and Clinical Features of Uveitis in a Tertiary Referral Center in Montpellier, France
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Uveitis
Keywords: Epidemiology
Clinical features
Etiology
Tertiary center
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2018-08-24
Enrollment: 985
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients seen at the specialized consultation for uveitis between January 2002 and july 2018

Brief summary: The aim of the study is to report the pattern of uveitis in patients attending a tertiary referral center at the University hospital in Montpellier. The patients seen at the specialized consultation for uveitis between 2002 and first semester 2018 were included.

Data about demography, clinical features and final diagnoses were collected and updated during the differenet visits. The medical records were restrospectively rewieved and analyzed.


Eligibility criteria: Inclusion Criteria:

* Patients seen at the specialized consultation for uveitis between 2002 and first semester 2018

Exclusion Criteria:

* Patients under 18

Primary outcomes:
measure: Etiology of uveitis
timeFrame: 1 day
Secondary outcomes:
measure: Demographic description of patients with uveitis
timeFrame: 1 day
measure: Clinical description of patients with uveitis
timeFrame: 1 day
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: Christelle Schneider, PUPH
role: STUDY_DIRECTOR
References:
Clinical trial NCT01803490: Bacterial Colonization of Suction Drains Following Spine Surgery
Official title: Bacterial Colonization of Suction Drains Following Spine Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Surgical Site Infection, Closed Suction Drains
Lead sponsor: Western Galilee Hospital-Nahariya
Sponsor class: OTHER_GOV
First posted: 2013-03-04
Enrollment: 224
Sex: ALL
Maximum age (years): 120
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing elective or emergent spine surgery in the normal course of activity at the Western Galilee Hospital spine surgery unit.

Brief summary: Closed suction drains are commonly used following surgery, if the wound is expected to discharge significant amounts of fluid. To this date, no evidence base exists as to the exact post operative time period or discharge volume necessitating presence of a drain. In orthopedic common practice, drains are removed on the second post operative day, fearing the drain will serve as a point of entry for nosocomial infection. In this study, drains will be left in place as long as daily discharge volume exceeds 50cc, regardless of the amount of days following surgery. Daily cultures and antibiotic levels will be taken from the drains receptacle, to determine if and when the drains is colonized by aerobic bacteria.


Eligibility criteria: Inclusion Criteria:

* All patients undergoing spine surgery that requires suction draining,and do not meet the exclusion criteria for this study.

Exclusion Criteria:

* Known active infection in the spine or elsewhere.

Primary outcomes:
measure: Growth of bacteria in drain fluids
timeFrame: up to 10 days per patient, (from first post operative day until removal of drains).
Secondary outcomes:
measure: antibiotic level in drain fluid
timeFrame: up to 10 days per patient (from first post operative day until removal of drains).
Other outcomes:
Locations:
city: Nahariya
country: Israel
facility: Western Galilee Hospital
Study officials:
affiliation: Head, Dept. of Orthopedics and spine surgery
name: nimrod t Rahamimov, md
role: PRINCIPAL_INVESTIGATOR
References: