louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06990490: Application of Lateral Position Digestive Endoscopy-Guided Endotracheal Intubation in Anesthesia for Endoscopic Diagnosis and Therapy
Official title: A Novel Endoscopy-Guided Airway Management Strategy for Lateral Decubitus Endoscopic Procedures
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Endotracheal Intubation
Gastrointestinal Endoscopy
Airway Management
Lateral Position
Lead sponsor: Qianfoshan Hospital
Sponsor class: OTHER
First posted: 2025-05-25
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This investigation was a case series study conducted in The First Affiliated Hospital of Shandong First Medical University \& Shandong Provincial Qianfoshan Hospital between February 2025 and March 2025. The study population comprised individuals requiring endotracheal intubation during elective gastrointestinal endoscopy in the left lateral position. Patients who declined informed consent were excluded.

Brief summary: This case series study evaluated whether placing a breathing tube using a camera (gastrointestinal endoscope) is safe and effective for patients lying on their left side during stomach and intestine exams under anesthesia. The main questions were:

How often does the tube placement work on the first try? How long does it take to place the tube? Are there any safety issues, like injuries or breathing problems?

Researchers enrolled 40 adults needing anesthesia for stomach/intestine exams. All participants had the breathing tube placed while lying on their left side using the camera-guided method. The steps included:

Positioning the patient on their left side with head/neck support. Inserting a lubricated camera through the mouth to view the throat. Placing the breathing tube into the windpipe under direct camera view.

The method avoided the risks of moving anesthetized patients from their back to the side. It may reduce risks linked to repositioning patients during surgery. Future studies with more participants and different medical teams are needed to confirm these results.


Eligibility criteria: Inclusion Criteria:

* The study population comprised individuals requiring endotracheal intubation during elective gastrointestinal endoscopy in the left lateral position

Exclusion Criteria:

* Patients who declined informed consent were excluded

Primary outcomes:
measure: The success rate of the first intubation attempt and intubation time (from endoscope insertion to tube connection)
timeFrame: From enrollment to the end of treatment at 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Jinan
country: China
facility: The First Affiliated Hospital of Shandong First Medical University
state: Shandong
Study officials:
References:
Clinical trial NCT00961090: Safety Study of Aminolevulinic Acid (ALA) to Improve Visibility of Brain Tumors During Surgery
Official title: A Phase 2 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Primary Glial Neoplasms of the Brain.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Glioblastoma
Keywords: Brain tumor
glioma
surgical resection
ALA
ultraviolet light
Lead sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Sponsor class: OTHER
Collaborators: name: DUSA Pharmaceuticals, Inc.
First posted: 2009-08-18
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A one time oral dose of ALA is taken before surgery. The medication makes the tumor visible under ultraviolet light which allow the surgeon to see more of the tumor for a more complete removal.

Detailed description: Patients with primary neoplastic brain tumors (Grades II-IV) will participate in this trial. Each patient will have been evaluated and found to have such a tumor by history and recent imaging studies (MRI) and deemed a surgical candidate based on current neurosurgical standards of care.

Eligibility criteria: Inclusion Criteria:

* Suspected primary brain tumor
* 18 years of age or more
* Normal marrow and organ function
* Eastern Cooperative Group performance status ≤ 2
* Women of childbearing potential must use adequate birth control
* Ability to understand and willingness to sign a written informed consent form
* Life expectancy not a consideration

Exclusion Criteria:

* Receiving any other investigational agents
* History of allergic reactions to ALA
* Personal or family history of porphyrias
* Liver disease in the past year
* Uncontrolled intercurrent illness
* Pregnant or lactating women
* Inability to undergo MRI with contrast

Primary outcomes:
measure: More complete resection of malignant brain tumors
timeFrame: 3-7 days
Secondary outcomes:
measure: Safety of drug
timeFrame: 1 month
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: Allegheny General Hospital
state: Pennsylvania
Study officials:
affiliation: The Guthrie Clinic
name: Matthew R Quigley, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05942690: Osteopathic Intervention in Professional Handball Players
Official title: Ultrasound Evaluation of Diaphragmatic Contractility After Manual Osteopathic Intervention in Professional Handball Players: a Pilot Study
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Osteopathia
Keywords: diaphragm
ultrasound
contractibility
osteopathic intervention
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2023-07-12
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The aim is to study the effectiveness of a common osteopathic intervention in professional handball players on diaphragmatic contractility and its correlations with posture. This study has never been done in healthy subjects. It is a scientific process of objectification of an osteopathic technique commonly performed in this population. The main objective is to assess diaphragmatic contractibility using ultrasound after abdominal osteopathic intervention (OMT).

Detailed description: The context is that of optimizing the performance of professional handball players. The aim is to study the effectiveness of a common osteopathic intervention in professional handball players on diaphragmatic contractility and its correlations with posture. This study has never been done in healthy subjects. It is a scientific process of objectification of an osteopathic technique commonly performed in this population.

The main objective is to assess diaphragmatic contractibility after abdominal osteopathic intervention (OMT).

The secondary objective is to evaluate the impact of this manual intervention in professional handball players on:

* other diaphragmatic ultrasound data
* on spirometry
* postural control

Prospective pilot non-interventional controlled monocentric study opened in healthy male and female International players who are part of the French Handball team. Approach to objectification of current practice.

Eligibility criteria: Inclusion Criteria:

* healthy male and female International players who are part of the French Handball team

Exclusion Criteria:

* history of thoracic or diaphragmatic surgery

Primary outcomes:
measure: Variation in the fraction of diaphragm thickening (right and left) measured on ultrasound before and after the procedure
timeFrame: Day 1
Secondary outcomes:
measure: expiratory diaphragmatic thickness
timeFrame: Day 1
measure: Variation of the Forced Vital Capacity (FVC) measured in spirometry before and after the intervention
timeFrame: Day 1
measure: Postural analysis
timeFrame: Day 2
measure: Inspiratory diaphragmatic thickness
timeFrame: day 1
measure: diaphragmatic contraction velocity
timeFrame: day 1
measure: diaphragmatic amplitude
timeFrame: day 1
Other outcomes:
Locations:
city: Créteil
country: France
facility: Maison du Handball
Study officials:
affiliation: CHU Toulouse
name: Elise NOEL-SAVINA, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03265990: Haemorrhoidectomy by Ligasure and Conventional Surgery
Official title: Comparison Between Haemorrhoidectomy by Ligasure and Conventional Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Ligature; Hemorrhage
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-08-29
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparison between Haemorrhoidectomy by Ligasure and conventional surgery

Detailed description: Hemorrhoids, a varicose condition are one of the commonest illnesses which causes per rectal bleeding . Hemorrhoidectomy is the standard operation for grades III and IV hemorrhoids; it is superior to any proposed conservative procedure. Conventional haemorrhoidectomy is the open surgical procedure in which the haemorrhoid pedicle is ligated by a transfixing suture which may lead to some postoperative complications mostly pain, bleeding and wound infection which ultimately cause prolonged stay in hospital.

A number of surgeons believe that by avoiding vascular pedicle ligation the chances of secondary bleeding can be decreased .This stimulated the researchers to develop new techniques with a less severe course and faster recovery . Recent advances in instrumental technology including the bipolar electrothermal device, ultrasonic scalpel, and circular stapler are gaining popularity as effective alternatives in hemorrhoidectomy . Of these instruments, the LigaSure vessel sealing system has been recently introduced as a tool conceived to upgrade the conventional treatment of haemorrhoids. This reduces anal spasm and allows performing a bloodless haemorrhoidectomy with reduced post- operative pain and fast healing . .Thus this operation can be recommended as the ideal technique. Many trials were performed to compare LigaSure hemorrhoidectomy with conventional hemorrhoidectomy, although an overall favorable trend exists toward LigaSure, conclusions are not univocal and definitive; this creates some uncertainty, also considering the increasing cost for this disposable device: thus it is essential to keep on experimenting to determine whenever an actual advantage exists.

Eligibility criteria: Inclusion Criteria:

* all patients with ages between 18 to 70 years with symptomatic grade III, or IV hemorrhoid who will be operated on at the Department of general Surgery, Assuit University Hospital

Exclusion Criteria:

* age older than 70 years
* patients with Grade I and II haemorrhoids
* patients on anticoagulants
* patients with liver cirrhosis
* patients with the hematological disorder
* patients with the concomitant anal disease
* patients had previous history of anorectal surgery

Primary outcomes:
measure: Post operative pain
timeFrame: 1 month
Secondary outcomes:
measure: Intra operative blood loss
timeFrame: 1 day
measure: Wound healing
timeFrame: 2 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04586790: the Effect of Oral Vasopressors for Liberation From IV Vasopressors in Spinal Shock
Official title: The Effect of Oral Midodrine Versus Oral Desmopressin Acetate Use for Liberation From IV Noradrenaline in Intensive Care Unit Patients Recovering From Spinal Shock .
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Spinal Shock
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-10-14
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: the study is developed to evaluate the effect of use of oral vasopressors (midodrine versus minirin) on weaning ICU patients from IV vasopressors (noradrenaline) and compare between them for efficacy in shortage the duration of IV vasopressor and has low complications and side effects.


Eligibility criteria: Inclusion Criteria:

* Age of 18 - 60 years.
* Patients of both genders.
* Patients diagnosed by spinal shock and they are in the recovery stage .

Exclusion Criteria:

* Patient refusal.
* Anuric or oliguric patients or patients with chronic kidney disease.
* Patients with allergy to medication included in the study.

Primary outcomes:
measure: liberation the patient from IV vasopressors with maintaining hemodynamics.
timeFrame: 48 hrs
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Ahmed Talaat Ahmed
Study officials:
affiliation: Assiut University
name: Ahmed T Ahmed, lecture
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04692090: Effects of Yoga on Phase Angle and Quality of Life in Patients With Breast Cancer
Official title: Effects of Yoga on Phase Angle and Quality of Life in Patients With Breast Cancer: A Randomized, Single-blind, Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Breast Cancer
Keywords: Phase Angle
Hatha Yoga
Breast Cancer
Quality of Life
Lead sponsor: Ege University
Sponsor class: OTHER
First posted: 2020-12-31
Enrollment: 31
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study,we aimed to examine the effects of Hatha yoga on PA and QoL in patients with breast cancer.

Patients will be randomized to receive the yoga group and the control group.Hatha yoga will be practiced twice a week for 10 weeks for intervention group.The PA of the patients will be assessed using a body analysis instrument and QoL was evaluated with an EORTC-Q questionnaire both before treatment and at week 10.


Eligibility criteria: Inclusion Criteria:

* Patients between the ages of 18 and 70, witha diagnosis of breast cancer

Exclusion Criteria:

* Patients with recurrent or progressive disease, or with serious heart or pulmonary disease, with uncontrolled hypertension, infection, cognitive function disorder, psychiatric disease or musculoskeletal system conditions that would prevent exercise, and those who had taken part in a regular exercise program

Primary outcomes:
measure: Phase Angle
timeFrame: 10 weeks
Secondary outcomes:
measure: The European Organization for Research and Treatment of Cancer Quality of life (EORTC QLQ-C30) questionnaire
timeFrame: 10 weeks
measure: Arm Volume
timeFrame: 10 weeks
measure: Body-Mass Index
timeFrame: 10 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02493790: Cognitive Dysfunction in COPD Patients : Role in the Performance of Cognitive-motor Dual Task Situation?
Official title: Impact of Cognitive Dysfunction in Chronic Obstructive Pulmonary Disease on Performance in Cognitive-motor Dual Task Situation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: cognitive dysfunction
Activity of Daily Living
interference
rehabilitation
cognitive-motor dual task
Lead sponsor: 5 Santé
Sponsor class: OTHER
Collaborators: name: Groupe 5 Santé
First posted: 2015-07-10
Enrollment: 45
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: COPD patients, entered in a rehabilitation program in Clinique du Souffle were included

Brief summary: Chronic Obstructive Pulmonary Disease (COPD) is a respiratory disease starting point characterized by multiple systemic effects as cognitive dysfunction. This one seems to have an impact in activity daily living, considered mainly as a cognitive-motor dual task situations. Yet to date, no study has specifically focused in the cognitive-motor performance in patients with COPD or on the effects during a rehabilitation program. The main objective of this work was to evaluate the impact of cognitive dysfunction in COPD, comparing performance between COPD patients and healthy subjects in a single and dual task cognitive-motor situation. The secondary objective was to assess the impact of a rehabilitation program on these performances.


Eligibility criteria: Inclusion Criteria:

* Male or female about 40 to 80 years old
* COPD patient (Tiffeneau \<70%); stage moderate to severe (Stage 2,3 and 4) with or without oxygen therapy (\>15h/day)
* Written and informed consent of the subject
* Authorization to physical activity referring doctor in the clinic
* Comorbidities no dominating

Exclusion Criteria:

* Subject with neurological pathology, cognitive or psychiatric
* Subject with pain and / or plantar injuries
* Subject has a prosthetic knee and / or hip.
* Subject requiring walking aid (cane, walker, etc.)

Primary outcomes:
measure: Variability of Cognitive performances in a single and dual task situations
timeFrame: 3 months
measure: Variability of motor performances in a single and dual task situations
timeFrame: 3 months
Secondary outcomes:
measure: Effect of rehabilitation program on Cognitive performances in a single and dual task
timeFrame: 3 months
measure: Effect of rehabilitation program on motor performances in a single and dual task
timeFrame: 3 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06952790: Fostering Oral Chemotherapy Understanding and Safety (FOCUS) Study
Official title: Fostering Oral Chemotherapy Understanding and Safety (FOCUS) Qualitative Study: Utilization of an Adherence Application
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Cancer
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2025-05-01
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to learn about the experiences of cancer patients during treatment utilizing a mobile app called EveryDose© to track prescribed oral treatment for cancer. Based on these experiences, the study team will decide on expanding this pilot study to evaluate other methods that may prove to be beneficial in supporting cancer patient's ability to take cancer medications as prescribed (another common phrase used for this is adherence to treatment).


Eligibility criteria: Inclusion Criteria:

* Any sex/gender Able to provide written informed consent
* Able to read/understand English or Spanish
* Diagnosis of hematologic or solid tumor cancer diagnosis
* Prescribed an oral anti-cancer drug as monotherapy treatment for the first time by their treating oncologist.
* Internet access on a smartphone, tablet, or computer

Exclusion Criteria:

* Less than 18 years of age
* Unable to provide written informed consent
* Unable to read/understand English or Spanish
* History of dementia or major psychiatric disease that would interfere with study participation
* Prior treatment with an oral anti-cancer treatment
* Participating in another clinical trial during the time of screening.

Primary outcomes:
measure: Percentage of patients who agree to use the EveryDose application
timeFrame: up to 12 weeks
measure: EveryDose application adherence measured by percentage
timeFrame: up to 12 weeks
measure: Medication Adherence measured by dose ratio
timeFrame: up to 12 weeks
Secondary outcomes:
measure: Percentage of patient satisfaction measured by SUS
timeFrame: 12 weeks (post intervention)
Other outcomes:
Locations:
city: Miami
country: United States
facility: University of Miami
state: Florida
Study officials:
affiliation: University of Miami
name: Frank Penedo, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00005703: Hemostasis in Sickle Cell Disease--Infancy to Adulthood
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anemia, Sickle Cell
Blood Disease
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Sponsor class: NIH
First posted: 2000-05-26
Sex: MALE
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: To assess in older children and adults with sickle cell disease (SCD) whether intrinsic activation (relevant to the origin of pain and acute inflammation) occurs only during vasocclusive crisis (VOC).

Detailed description: BACKGROUND:

Investigations into hemostatic abnormalities associated with sickle cell disease have been numerous. The data suggested that thrombin generation and fibrin formation were increased during steady state, with conflicting data whether further activation occurred in vaso-occlusive crisis. Platelet activation during VOC occurred, with variable findings during steady state. A selective, concomitant evaluation of the hemostatic pathways i.e. intrinsic, tissue factor (TF) or extrinsic activation, fibrinolysis, and platelet-endothelial activation had not been reported. Neither had a longitudinal evaluation been performed in infants during the unique transition period when HbF levels fall from 70 to 80 percent to less than 10 percent.

The study was part of an initiative on "Coagulation, Platelets and Thrombosis in Sickle Disease Pathophysiology". The Request for Applications was released in October 1994.

DESIGN NARRATIVE:

The studies used appropriate 'negative' and 'positive' control groups. Studies included intrinsic markers \[kininogen profiling, high molecular weight kininogen (HK) and low molecular weight kininogen (LK) cleavages, western blotting of HK and LK, and kallikrein-alpha2 macroglobulin; extrinsic markers \[TF and factor V11a\]; other activation and fibrinolytic markers \[prothrombin F1.2, FPA, TAT, tPA, PAI-I, D-dimer and plasma alpha2 antiplasmin\]; platelet- endothelial markers \[evaluation of activation dependent epitopes\]. Unequivocal demonstration of contact pathway activation during VOC provided a crucial link between VOC and its accompanying phenomenon including pain, and inflammation. Finally, the studies provided a unique perspective on the continuum of hemostatic changes that unfolded during the course of SCD, and those that developed as vascular insufficiencies supervened in the adult.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Eligibility criteria: No eligibility criteria

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Thomas Jefferson University
name: Marie Stuart
References: