Clinical trial NCT03278743: Tea Consumption and Cognitive Performance in the Very Old
Official title: Higher Tea Consumption is Associated With Better Performance on Measures of Attention and Psychomotor Speed in the Very Old: The Newcastle 85+ Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cognition
Keywords: tea
cognition
very old
Newcastle 85+
epidemiology
Lead sponsor: Newcastle University
Sponsor class: OTHER
First posted: 2017-09-12
Enrollment: 1042
Sex: ALL
Minimum age (years): 85
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community-dwelling and institutionalized men and women recruited through general medical practices in North East England, UK (n=676) and born in 1921 (85 years old at baseline).

Brief summary: Studies have found a beneficial effect of tea consumption on the reduction of risk of cognitive impairment and dementia in older aged populations. However, there is a paucity of data on these associations in the very old defined as individuals aged 85 years and over. Therefore, we hypothesized that higher tea consumption was associated with better global and domain-specific cognitive function. We investigated the relationship between tea consumption in the very old and measures of global cognitive function, memory, attention and psychomotor speed.

The Newcastle 85+ Study was a longitudinal (5-years), population-based cohort study of individuals aged 85+ years in North East England, United Kingdom. The final sample included 676 community-dwelling and institutionalized men and women recruited through general medical practices.

Baseline tea consumption was assessed through a 2x24-hr multiple pass recall and longitudinal measures of global and domain specific (memory, speed and attention) cognitive function through the standardized mini-mental state examination and the cognitive drug research system. Linear mixed models, controlling for demographic (e.g. age, sex and education) and health variables were used to determine whether tea consumption was protective against cognitive decline.


Eligibility criteria: Inclusion Criteria:

* Born in 1921
* Permanently registered with a participating general practice in Newcastle upon Tyne or North Tyneside primary care trusts in the UK

Exclusion Criteria:

* End-stage illness
* Individuals who might pose a safety risk to a nurse visiting alone, with dementia
* Clinical diagnosis of dementia at baseline

Primary outcomes:
measure: Standardized mini-mental state examination
timeFrame: Baseline
measure: Rate of decline of the standardized mini-mental state examination
timeFrame: Baseline to 5 years follow-up
Secondary outcomes:
measure: Simple reaction time
timeFrame: Baseline
measure: Rate of reaction speed decline
timeFrame: Baseline to 3 years follow-up
measure: Choice reaction time
timeFrame: Baseline
measure: Rate of reaction choice decline
timeFrame: Baseline to 3 years follow-up
measure: Digit vigilance task
timeFrame: Baseline
measure: Rate of digit vigilance task decline
timeFrame: Baseline to 3 years follow-up
measure: Word recognition
timeFrame: Baseline
measure: Rate of word recognition decline
timeFrame: Baseline to 3 years follow-up
Other outcomes:
Locations:
city: Newcastle upon Tyne
country: United Kingdom
facility: Newcastle University
Study officials:
affiliation: Newcastle University
name: Tom Kirkwood
role: PRINCIPAL_INVESTIGATOR
References: