Clinical trial NCT06118190: Mesotherapy in the Treatment of Chronic Migraine
Official title: The Effectiveness of Mesotherapy (Lidocaine and Proxicam) in the Treatment of Chronic Migraine
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Migraine, Headache
Keywords: Mesotherapy
Chronic Migraine
pain
muscle
headache
Lead sponsor: Kanuni Sultan Suleyman Training and Research Hospital
Sponsor class: OTHER
First posted: 2023-11-07
Enrollment: 27
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Retrospective analysis of the group that received treatment
Primary purpose: TREATMENT

Brief summary: Mesotherapy is a type of injection frequently used in clinics. It is a treatment procedure that involves the injection of some drugs under the skin or into the skin. Mesotherapy is used in musculoskeletal system diseases, but it is reported that the effects of its use in migraine are uncertain.

Detailed description: Migraine is one of the types of headaches. For the diagnosis of chronic migraine, the headache must last more than 15 days. Nerve blocks, oral medication and neuromodulation are recommended for migraine treatment.Mesotherapy is a type of injection frequently used in clinics. It is a treatment procedure that involves the injection of some drugs under the skin or into the skin. Mesotherapy is used in musculoskeletal system diseases, but it is reported that the effects of its use in migraine are uncertain. This study was planned to show the effectiveness of mesotherapy in patients with migraine.

Eligibility criteria: Inclusion Criteria:

- Clinical diagnosis of chronic migraine disease

Exclusion Criteria:

* Infection disease
* Thyroid disease
* Anemia disease
* Systemic disease

Primary outcomes:
measure: Visual Analog Scale (VAS)
timeFrame: Baseline
measure: Visual Analog Scale (VAS)
timeFrame: 4th week
measure: Visual Analog Scale (VAS)
timeFrame: 8th week
measure: Visual Analog Scale (VAS)
timeFrame: 12 th week
measure: The frequency of painful days per month
timeFrame: Baseline
measure: The frequency of painful days per month
timeFrame: 4th week
measure: The frequency of painful days per month
timeFrame: 8th week
measure: The frequency of painful days per month
timeFrame: 12th week
Secondary outcomes:
measure: Duration of attack per month
timeFrame: Baseline
measure: Duration of attack per month
timeFrame: 4th week
measure: Duration of attack per month
timeFrame: 8th week
measure: Duration of attack per month
timeFrame: 12th week
measure: the number of analgesic per month
timeFrame: Baseline
measure: the number of analgesic per month
timeFrame: 4th week
measure: the number of analgesic per month
timeFrame: 8th week
measure: the number of analgesic per month
timeFrame: 12th week
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Kanni Sultan Suleyman Research and Training Hospital
state: Kucukcekmece
Study officials:
affiliation: Kanuni Sultan Suleyman Research and Training Hospital
name: Elif Ozyigit, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Costantino C, Marangio E, Coruzzi G. Mesotherapy versus Systemic Therapy in the Treatment of Acute Low Back Pain: A Randomized Trial. Evid Based Complement Alternat Med. 2011;2011:317183. doi: 10.1155/2011/317183. Epub 2010 Sep 1.
citation: Ravishankar K, Tayade H, Mandlik R. Sublingual piroxicam in migraine without aura. J Assoc Physicians India. 2011 Aug;59:494-7.