Clinical trial NCT00959855: Long-term Impact of Pulmonary Rehabilitation
Official title: Long-term Evaluation of Activity and Health Status Pre and Post Pulmonary Rehabilitation - A Multi-Centred Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: COPD
Pulmonary Rehabilitation
Inflammation
Oxidative Stress
Steps
Free Living Activities
Exacerbation
Lead sponsor: Beaumont Hospital
Sponsor class: OTHER
Collaborators: name: ITS Pulmonary Rehabilitation Research Network
First posted: 2009-08-17
Enrollment: 120
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study has been designed to capture a large group of patients who undergo pulmonary rehabilitation and map their progression over a 5 year time-frame.

The outcome measures have been chosen to capture physiological, functional capacity, free-living activities plus admission and exacerbation rates thereby enhancing our understanding of the potential effects exercise and self management techniques may have on the disease progression.

Pulmonary rehabilitation has not been shown to reduce inflammation; therefore, unlike acute exacerbation's where a decrease in inflammation indicates recovery, the exact mechanisms responsible for improvement during pulmonary rehabilitation are as yet unknown.

Detailed description: The benefits of pulmonary rehabilitation are well documented elsewhere, however, the exact mechanisms responsible for these significant improvements and alteration of the disease progression are unexplained. Also unexplained is the apparent lack of carry over of functional capacity into free-living activities as measured by activity monitors.

There are no reported effects on decreasing level of inflammatory cytokines or C-reactive protein (CRP) post rehabilitation, however, a training response to reactive oxidative stress (ROS) after a moderate intensity pulmonary rehabilitation programme has been reported. As oxidative stress is a catalyst to inflammation, a training response to exercise induced ROS in patients with COPD may also have a secondary effect of modifying inflammation in the stable COPD patient thereby improving patient outcomes.

No studies to-date have combined free-living activities, biomarkers and standard outcome measures in patient's pre and post pulmonary rehabilitation or follow-up patients over a five year period.

Subjects referred to pulmonary rehabilitation who fulfil the GOLD criteria for COPD will be recruited on a rolling basis and randomly allocated to one of two groups. Group 1 (Control), Group 2 (Intervention).

It is a multi-centred, randomised controlled trial using the above convenience sample of patients referred to pulmonary rehabilitation who meet the inclusion/exclusion criteria.

Eligibility criteria: Inclusion Criteria:

1. A diagnosis of COPD based on the GOLD staging of the Disease
2. MMRC score of 3 or above
3. Ability to mobilize independently
4. Willing to comply with the home exercise and inspiratory muscle training programmes
5. Willing to wear the SenseWare Armband
6. Optimal medical management
7. No adverse effects to exercise testing
8. Patient's awaiting lung transplant

Exclusion Criteria:

1. Evidence of ischemic heart disease/acute changes on ECG
2. Uncontrolled hypertension
3. Insulin dependent diabetes mellitus
4. Uncontrolled CCF / idiopathic cardiomyopathy
5. Reversible Asthma
6. A diagnosis of lung cancer/TB/recent pneumothorax/PE or pneumonia
7. Any musculoskeletal/neurological condition which would render the patient incapable of completing the course
8. Exacerbation of COPD within 4 weeks of program
9. Poor cognitive status
10. Previous attendance at a pulmonary rehabilitation program

Primary outcomes:
measure: Quality of life score
timeFrame: One year
Secondary outcomes:
measure: Spiromtery
timeFrame: 12 months
measure: Number of exacerbations of COPD.
timeFrame: over one year
Other outcomes:
Locations:
city: Beaumont
country: Ireland
facility: Beaumont Hospital
state: Dublin
Study officials:
affiliation: Beaumont Hosptial
name: Richard Costello, Professor
role: PRINCIPAL_INVESTIGATOR
References: