Clinical trial NCT03541538: Hypoalgesic Effect of Cervical Manipulation
Official title: Hypoalgesic Effects of Specific vs Non-specific Cervical Manipulation in Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain
Keywords: joint manipulation
cervical
pressure pain
manual therapy
Lead sponsor: Universidade Federal de Sao Carlos
Sponsor class: OTHER
First posted: 2018-05-30
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Participants received two interventions randomly at two times: global manipulation (GM) and specific manipulation (MS)
Primary purpose: BASIC_SCIENCE

Brief summary: This study evaluates the hypoalgesic effect of global and specific cervical joint manipulation in healthy individuals. At first the participants received one of the interventions and after 48 hours, the other.

Detailed description: Cervical Joint Manipulation (CJM) are often used for pain treatment.

Joint manipulation generates a series of stimuli within the central nervous system through the activation of proprioceptors located in the joint capsule or muscles, stimulates the PAG, causing pain inhibition by activation of non-opioid descending inhibitory pathways.

Eligibility criteria: Inclusion Criteria:

* healthy subjects of both sexes
* without pain complaints in the last 90 days

Exclusion Criteria:

* previous spinal surgeries
* spinal canal stenosis
* vertebral fracture
* spondylolisthesis
* cancer
* acute infections
* hemorrhagic disorders
* active tuberculosis
* deep vein thrombosis
* osteoporosis
* rheumatic diseases
* metabolic diseases
* cardiorespiratory diseases
* smoking injury
* musculoskeletal injury
* use of pacemaker
* women in menstrual period
* pregnant women
* use of pain-killers in the last 48 hours
* use of anti-inflammatory drugs in the last 48 hours
* previous joint manipulation treatments
* aversion to cervical joint manipulation
* positivity in the vertebral artery test
* headache in the last seven days

Primary outcomes:
measure: Pressure Pain Threshold at the posterior region of the forearm
timeFrame: 1 minute after the end of the intervention.
Secondary outcomes:
Other outcomes:
Locations:
city: São Carlos
country: Brazil
facility: Ufscar - Universidade Federal de São Carlos
state: São Paulo
Study officials:
affiliation: Universidade Federal de São Carlos - UFScar
name: Richard E Liebano, Dr.
role: PRINCIPAL_INVESTIGATOR
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