Clinical trial NCT03915964: A Study of Baricitinib (LY3009104) in Participants With Rheumatoid Arthritis
Official title: A Randomized, Active-Controlled, Parallel-Group, Phase 3b/4 Study of Baricitinib in Patients With Rheumatoid Arthritis
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE4
Conditions: Rheumatoid Arthritis
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
Collaborators: name: Incyte Corporation
First posted: 2019-04-16
Enrollment: 2600
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This post-marketing study is designed to compare the safety of baricitinib versus tumor necrosis factor (TNF) inhibitors with respect to venous thromboembolic events (VTEs) when given to participants with rheumatoid arthritis.


Eligibility criteria: Inclusion Criteria:

* Participants must have at least one of the following characteristics:

  * Documented evidence of a VTE prior to this study
  * At least 60 years of age
  * A body mass index (BMI) greater than or equal to 30 kilograms per meter squared (kg/m²), or
  * Age 50 to less than 60 years and BMI 25 to less than 30 kg/m².
* Participants must have an inadequate response or intolerance to at least 1 disease-modifying antirheumatic drugs (DMARD) (synthetic or biologic).

Exclusion Criteria:

* Participant should have no reason to not take a TNF inhibitor.
* Participants must not be pregnant or breastfeeding.
* Participants must not have had more than one VTE.
* Participants must not have cancer.
* Participants must not have active herpes zoster, serious infection, active tuberculosis, or any other serious illness.
* Participants must not have had a live vaccine within four weeks of study start.
* Participants must not have participated in any other clinical trial within four weeks of study start.
* Participants must not have a history of IV drug use, other illicit drug abuse, or chronic alcohol abuse in the past year.

Primary outcomes:
measure: Time from First Dose of Study Treatment to First Event of Venous Thromboembolism (VTE)
timeFrame: Baseline through Study Completion (Approximately 5.5 Years)
Secondary outcomes:
measure: Time from First Dose of Study Treatment to First Arterial Thromboembolic Event (ATE)
timeFrame: Baseline through Study Completion (Approximately 5.5 Years)
measure: Time from First Dose of Study Treatment to First Major Adverse Cerebro-Cardiovascular Event (MACE)
timeFrame: Baseline through Study Completion (Approximately 5.5 Years)
measure: Time from First Dose of Study Treatment to First Malignancy (excluding nonmelanoma skin cancer [NMSC])
timeFrame: Baseline through Study Completion (Approximately 5.5 Years)
measure: Time from First Dose of Study Treatment to First Opportunistic Infection
timeFrame: Baseline through Study Completion (Approximately 5.5 Years)
measure: Time from First Dose of Study Treatment to First Serious Infection
timeFrame: Baseline through Study Completion (Approximately 5.5 Years)
Other outcomes:
Locations:
city: Flagstaff
country: United States
facility: Arizona Arthritis & Rheumatology Research, PLLC
state: Arizona
city: Gilbert
country: United States
facility: Arthrocare, Arthritiscare & Research Pc
state: Arizona
city: Glendale
country: United States
facility: Arizona Arthritis & Rheumatology Research, PLLC
state: Arizona
city: Mesa
country: United States
facility: Arizona Arthritis & Rheumatology Research, PLLC
state: Arizona
city: Peoria
country: United States
facility: Hope Research Institute
state: Arizona
city: Phoenix
country: United States
facility: Hope Research Institute
state: Arizona
city: Tucson
country: United States
facility: Arizona Arthritis & Rheumatology Research, PLLC
state: Arizona
city: Covina
country: United States
facility: Medvin Clinical Research - Covina
state: California
city: Fullerton
country: United States
facility: St Joseph Heritage Healthcare
state: California
city: Huntington Beach
country: United States
facility: Christine Thai, MD
state: California
city: Irvine
country: United States
facility: Private Practice - Dr. Christine J. Leehealey
state: California
city: Rancho Mirage
country: United States
facility: Desert Medical Advances
state: California
city: San Diego
country: United States
facility: Rheumatology Center of San Diego
state: California
city: San Leandro
country: United States
facility: East Bay Rheumatology Medical Group, Inc
state: California
city: Tujunga
country: United States
facility: Dan La, MD Inc
state: California
city: Tustin
country: United States
facility: Robin K. Dore MD, Inc
state: California
city: Upland
country: United States
facility: Inland Rheumatology & Osteoporosis Medical Group
state: California
city: Van Nuys
country: United States
facility: Medvin Clinical Research - Weidmann
state: California
city: Whittier
country: United States
facility: Medvin Clinical Research - Whittier
state: California
city: Stamford
country: United States
facility: Stamford Therapeutics Consortium
state: Connecticut
city: Boca Raton
country: United States
facility: Rheumatology Associates of South Florida
state: Florida
city: Miami
country: United States
facility: Suncoast Research Group
state: Florida
city: Miami
country: United States
facility: New Horizon Research Center
state: Florida
city: New Port Richey
country: United States
facility: Suncoast Clinical Research, Inc.
state: Florida
city: Plantation
country: United States
facility: IRIS Research and Development, LLC
state: Florida
city: South Miami
country: United States
facility: Qps-Mra, Llc
state: Florida
city: Tampa
country: United States
facility: ForCare Clinical Research
state: Florida
city: Atlanta
country: United States
facility: Arthritis & Rheumatology of Georgia
state: Georgia
city: Gainesville
country: United States
facility: Arthritis Center of North Georgia
state: Georgia
city: Boise
country: United States
facility: St. Luke's Intermountain Research Center
state: Idaho
city: Chicago
country: United States
facility: Great Lakes Clinical Trials
state: Illinois
city: Evansville
country: United States
facility: Qualmedica Research, LLC
state: Indiana
city: Wichita
country: United States
facility: Alliance for Multispecialty Research, LLC
state: Kansas
city: Elizabethtown
country: United States
facility: Center for Arthritis and Osteoporosis
state: Kentucky
city: Lake Charles
country: United States
facility: Accurate Clinical Research
state: Louisiana
city: Wheaton
country: United States
facility: The Center for Rheumatology and Bone Research
state: Maryland
city: Fall River
country: United States
facility: NECCR PrimaCare Research
state: Massachusetts
city: Brighton
country: United States
facility: University of Michigan
state: Michigan
city: Grand Rapids
country: United States
facility: West Michigan Rheumatology
state: Michigan
city: Okemos
country: United States
facility: Advanced Rheumatology, PC
state: Michigan
city: Saint Peters
country: United States
facility: StudyMetrix Research
state: Missouri
city: Springfield
country: United States
facility: Clinvest Research LLC
state: Missouri
city: Kalispell
country: United States
facility: Glacier View Research Institute
state: Montana
city: Lincoln
country: United States
facility: Physician Research Collaboration, LLC
state: Nebraska
city: Omaha
country: United States
facility: Westroads Clinical Research, Inc.
state: Nebraska
city: Reno
country: United States
facility: Allied Clinical Research
state: Nevada
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center
state: New Hampshire
city: Albuquerque
country: United States
facility: Albuquerque Center for Rheumatology
state: New Mexico
city: Albuquerque
country: United States
facility: Albuquerque Clinical Trials, Inc.
state: New Mexico
city: Santa Fe
country: United States
facility: Santa Fe Rheumatology
state: New Mexico
city: Charlotte
country: United States
facility: Accellacare - Charlotte
state: North Carolina
city: Durham
country: United States
facility: M3-Emerging Medical Research, LLC
state: North Carolina
city: Hickory
country: United States
facility: Piedmont Rheumatology, P.A.
state: North Carolina
city: Leland
country: United States
facility: Cape Fear Arthritis Care
state: North Carolina
city: Salisbury
country: United States
facility: PMG Research of Salisbury
state: North Carolina
city: Wilmington
country: United States
facility: PMG Research of Wilmington, LLC
state: North Carolina
city: Cincinnati
country: United States
facility: Cincinnati Rheumatic Disease Study Group
state: Ohio
city: Marietta
country: United States
facility: Marietta Memorial Hospital
state: Ohio
city: Middleburg Heights
country: United States
facility: Paramount Medical Research & Consulting, LLC
state: Ohio
city: Oklahoma City
country: United States
facility: Health Research of Oklahoma
state: Oklahoma
city: Oklahoma City
country: United States
facility: Oklahoma Medical Research Foundation
state: Oklahoma
city: Bethlehem
country: United States
facility: East Penn Rheumatology Associates
state: Pennsylvania
city: Duncansville
country: United States
facility: Altoona Center For Clinical Research
state: Pennsylvania
city: Wyomissing
country: United States
facility: Clinical Research Center of Reading,LLC
state: Pennsylvania
city: Wyomissing
country: United States
facility: Pennsylvania Regional Center for Arthritis and Osteoporosis Research
state: Pennsylvania
city: Rapid City
country: United States
facility: Regional Health Clinical Research
state: South Dakota
city: Baytown
country: United States
facility: Accurate Clinical Management
state: Texas
city: College Station
country: United States
facility: Arthritis & Osteoporosis Clinic of Brazos Valley
state: Texas
city: Houston
country: United States
facility: Biopharma Informatic, LLC
state: Texas
city: Houston
country: United States
facility: Accurate Clinical Management - Houston
state: Texas
city: Houston
country: United States
facility: Accurate Clinical Research
state: Texas
city: Houston
country: United States
facility: Research Physicians Network, LLC
state: Texas
city: League City
country: United States
facility: Accurate Clinical Research
state: Texas
city: San Antonio
country: United States
facility: Accurate Clinical Research, Inc.
state: Texas
city: San Antonio
country: United States
facility: Clinical Trials of Texas, Inc.
state: Texas
city: Sugar Land
country: United States
facility: Accurate Clinical Management
state: Texas
city: Tomball
country: United States
facility: Dynamed Clinical Research, LP d/b/a DM Clinical Research
state: Texas
city: Tomball
country: United States
facility: DM Clinical Research/Rheumatology Clinic of Houston
state: Texas
city: Spokane
country: United States
facility: Arthritis Northwest, PLLC
state: Washington
city: Vancouver
country: United States
facility: The Vancouver Clinic
state: Washington
city: Charleston
country: United States
facility: CAMC Health Education and Research Institute Inc
state: West Virginia
city: Botany
country: Australia
facility: Optimus Clinical Research
state: New South Wales
city: Newcastle
country: Australia
facility: Genesis Research Services
state: New South Wales
city: Maroochydore
country: Australia
facility: Rheumatology Research Unit
state: Queensland
city: Hobart
country: Australia
facility: Southern Clinical Research
state: Tasmania
city: Camberwell
country: Australia
facility: Emeritus Research
state: Victoria
city: Vienna
country: Austria
facility: Medizinische Universität Wien
state: Wien
city: Vienna
country: Austria
facility: Wilhelminenspital
state: Wien
city: Wien
country: Austria
facility: Rheuma-Zentrum Oberlaa GmbH
city: Brussels
country: Belgium
facility: Université Libre de Bruxelles - Hôpital Erasme
state: Bruxelles-Capitale, Région De
city: Genk
country: Belgium
facility: Reuma Clinic, Locatie Jaarbeurslaan
state: Limburg
city: Merksem
country: Belgium
facility: ZNA Jan Palfijn
state: Vlaams Gewest
city: Brno
country: Czechia
facility: Revmacentrum MUDr. Mostera, s.r.o.
state: Brno-město
city: Brno
country: Czechia
facility: Revmatologie.s.r.o.
state: Brno-město
city: Brno
country: Czechia
facility: REVMACLINIC s.r.o.
state: Jihomoravský Kraj
city: Ostrava
country: Czechia
facility: Artroscan, s.r.o.
state: Moravskoslezský Kraj
city: Ostrava
country: Czechia
facility: INREA s.r.o.
state: Ostrava Město
city: Pardubice
country: Czechia
facility: ARTHROHELP s.r.o.
state: Pardubický Kraj
city: Praha
country: Czechia
facility: Clintrial s.r.o.
state: Praha 10
city: Praha
country: Czechia
facility: Revmatologie MUDr. Štejfová
state: Praha 4
city: Praha 2
country: Czechia
facility: Revmatologicky ustav
state: Praha, Hlavní Mešto
city: Uherske Hradiste
country: Czechia
facility: Medical Plus
state: Zlínský Kraj
city: Zlín
country: Czechia
facility: PV Medical Services s.r.o.
state: Zlínský Kraj
city: Praha 11
country: Czechia
facility: Affidea Praha, s.r.o.
city: Praha 4
country: Czechia
facility: Revmatologicka ambulance
city: Silkeborg
country: Denmark
facility: Regionshospitalet Silkeborg
state: Midtjylland
city: Svendborg
country: Denmark
facility: Reumatologisk Ambulatorie, Svendborg Hospital Odense Universitet Hospital
state: Syddanmark
city: Nice
country: France
facility: CHU de Nice
state: Alpes-Maritimes
city: Strasbourg
country: France
facility: CHU Strasbourg-Hautepierre
state: Alsace
city: Bordeaux
country: France
facility: Bordeaux University Hospital - Pellegrin
state: Aquitaine
city: Orléans
country: France
facility: Centre Hospitalier Regional D'Orleans
state: Centre
city: Toulouse
country: France
facility: Hôpital Pierre-Paul Riquet
state: Haute-Garonne
city: Nantes
country: France
facility: Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
state: Loire-Atlantique
city: Vandoeuvre lès Nancy
country: France
facility: Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
state: Meurthe-et-Moselle
city: Lyon
country: France
facility: Hôpital Edouard Herriot
state: Rhône-Alpes
city: La Roche-sur-Yon
country: France
facility: CHD Vendee
state: Vendée
city: Caluire et Cuire
country: France
facility: Infirmerie Protestante de Lyon
city: Lille
country: France
facility: Centre Hospitalier Régional Universitaire de Lille - Hôpital Roger Salengro
city: Paris
country: France
facility: Pitie Salpetriere University Hospital
city: Frankfurt
country: Germany
facility: CIRI- Center of Innovative Diagnostics and Therapeutics Rheumatology/Immunology
state: Hessen
city: Bad Doberan
country: Germany
facility: Rheumazentrum Prof.Neeck MVZ
state: Mecklenburg-Vorpommern
city: Köln
country: Germany
facility: Universitaetsklinikum Koeln
state: Nordrhein-Westfalen
city: Ratingen
country: Germany
facility: Rheumazentrum Ratingen Studienambulanz
state: Nordrhein-Westfalen
city: Magdeburg
country: Germany
facility: Institut für Präventive Medizin & Klinische Forschung GbR
state: Sachsen-Anhalt
city: Berlin
country: Germany
facility: Praxis für Rheumatologie und Innere
city: Berlin
country: Germany
facility: Schlosspark Klinik
city: Hamburg
country: Germany
facility: HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T
city: Hamburg
country: Germany
facility: Hamburger Rheuma Forschungszentrum I / Dres Raabe & Heintz
city: Chaidari
country: Greece
facility: Attikon General University Hospital
state: Attikí
city: Thessaloniki
country: Greece
facility: Ippokrateio General Hospital of Thessaloniki
state: Kentrikí Makedonía
city: Alexanroupolis
country: Greece
facility: University Hospital of Alexandroupolis
state: Évros
city: Miskolc
country: Hungary
facility: CRU Hungary Kft.
state: Borsod-Abaúj-Zemplén
city: Budapest
country: Hungary
facility: Revita Clinic
state: Pest
city: Budapest
country: Hungary
facility: Clinexpert Kft.
state: Pest
city: Veszprem
country: Hungary
facility: Vital Medical Center
state: Veszprém City
city: Debrecen
country: Hungary
facility: Debreceni Egyetem - Kenézy Gyula Egyetemi Oktatókórház
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont
city: Ashkelon
country: Israel
facility: Barzilai Medical Center
state: HaDarom
city: Kfar Saba
country: Israel
facility: Meir Medical Center
state: HaMerkaz
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
state: HaMerkaz
city: Tel Aviv
country: Israel
facility: Sourasky Medical Center
state: Tell Abīb
city: Haifa
country: Israel
facility: Rambam Health Care Campus
state: Ḥeifā
city: Haifa
country: Israel
facility: Carmel Hospital
state: Ḥeifā
city: Haifa
country: Israel
facility: Bnai Zion Medical Center
state: Ḥeifā
city: Chieti
country: Italy
facility: Clinical Research Center - Universita Degli Studi Gabriele d'Annunzio
state: Abruzzo
city: Milan
country: Italy
facility: Ospedale Luigi Sacco
state: Milano
city: Siena
country: Italy
facility: Ospedale Le Scotte
state: Toscana
city: Firenze
country: Italy
facility: Azienda Ospedaliera Universitaria Careggi
city: Napoli
country: Italy
facility: University of Campania Luigi Vanvitelli
city: Verona
country: Italy
facility: Policlinico GB Rossi Borgo Roma
city: Kaunas
country: Lithuania
facility: Republican Hospital of Kaunas
state: Kauno Miestas
city: Vilnius
country: Lithuania
facility: Centro poliklinika
city: Siauliai
country: Lithuania
facility: Respublikin Šiauli ligonin
state: Šiauliai
city: Leeuwarden
country: Netherlands
facility: Medische Centrum Leeuwarden
state: Fryslân
city: Born
country: Netherlands
facility: PT&R / PreCare Trial & Recruitment
state: Limburg
city: Bydgoszcz
country: Poland
facility: Szpital Uniwersytecki Nr 2 w Bydgoszczy, Klinika Reumatologii i Ukladowych Chorób Tkanki Lacznej
state: Kujawsko-pomorskie
city: Torun
country: Poland
facility: MICS Centrum Medyczne Torun
state: Kujawsko-pomorskie
city: Tomaszów Lubelski
country: Poland
facility: Samodzielny Publiczny Zespol Opieki Zdrowotnej W Tomaszowie Lubelskim
state: Lubelskie
city: Nowa Sol
country: Poland
facility: Twoja Przychodnia Centrum Medyczne Nowa Sol
state: Lubuskie
city: Nadarzyn
country: Poland
facility: NZOZ Lecznica MAK-MED s.c.
state: Mazowieckie
city: Warszawa
country: Poland
facility: Medycyna Kliniczna
state: Mazowieckie
city: Warszawa
country: Poland
facility: Rheuma Medicus- Zak��ad Opieki Zdrowotnej
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centrum Medyczne Reuma Park
state: Mazowieckie
city: Warszawa
country: Poland
facility: ETG Warszawa
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centrum Medyczne AMED Warszawa Targowek
state: Mazowieckie
city: Bialystok
country: Poland
facility: Osteo Medic sc A. Racewicz, J. Supronik
state: Podlaskie
city: Gdansk
country: Poland
facility: Centrum Badan Klinicznych PI-House sp. z o.o.
state: Pomorskie
city: Elblag
country: Poland
facility: Ambulatorium Barbara Bazela
state: Warmińsko-mazurskie
city: Poznan
country: Poland
facility: Ai Centrum Medyczne Sp. Z O.O.
state: Wielkopolskie
city: Poznan
country: Poland
facility: Prywatna Praktyka Lekarska Prof. UM dr hab. med. Pawel Hrycaj
state: Wielkopolskie
city: Bytom
country: Poland
facility: BIF-MED
state: Śląskie
city: Katowice
country: Poland
facility: Centrum Medyczne Pratia Katowice
state: Śląskie
city: Ustron
country: Poland
facility: Slaskie Centrum Reumatologii, Rehabilitacji I Zapobiegania Niepelnosprawnosci Im. Gen.J.Zietka
state: Śląskie
city: Caguas
country: Puerto Rico
facility: Centro Reumatologico Caguas
city: Ponce
country: Puerto Rico
facility: Ponce Medical School Foundation Inc.
city: San Juan
country: Puerto Rico
facility: Latin Clinical Trial Center
city: San Juan
country: Puerto Rico
facility: GCM Medical Group, PSC - Hato Rey Site
city: San Juan
country: Puerto Rico
facility: Mindful Medical Research
city: Brasov
country: Romania
facility: C.M.D.T.A. Neomed
state: Brașov
city: Braila
country: Romania
facility: Cmi Cristei Dorica
state: Brăila
city: Bucharest
country: Romania
facility: Spital Clinic Sf. Maria
state: București
city: Bucharest
country: Romania
facility: Delta Health Care
state: București
city: Bucuresti
country: Romania
facility: CCBR Clinical Research
state: București
city: Galati
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei
state: Galați
city: Iasi
country: Romania
facility: RK Medcenter
state: Iași
city: Baia Mare
country: Romania
facility: Spitalul Judeean de Urgen Dr. Constantin Opri Baia Mare
state: Maramureș
city: Râmnicu Vâlcea
country: Romania
facility: Sc Medaudio-Optica Srl
state: Vâlcea
city: Kursk
country: Russian Federation
facility: Kursk Regional Clinical Hospital
state: Kurskaya Oblast'
city: Saint-Petersburg
country: Russian Federation
facility: Gbuz Lokb
state: Leningradskaya Oblast'
city: Moscow
country: Russian Federation
facility: First Moscow State Medical University I.M. Sechenov
state: Moskovskaya Oblast'
city: Moscow
country: Russian Federation
facility: Moscow Clinical Research Center
state: Moskva
city: Moscow
country: Russian Federation
facility: Federal State Budgetary Scientific Institution Research Institute Rheumatology named after V.A.Nasonova
state: Moskva
city: Moscow
country: Russian Federation
facility: M. F. Vladimirskiy Moscow Regional Research Clinical Institute
state: Moskva
city: Nizhny Novgorod
country: Russian Federation
facility: Nizhny Novgorod City Clinical Hospital Number 5
state: Nizhegorodskaya Oblast'
city: Ryazan
country: Russian Federation
facility: Ryazan Regional Clinical Cardiological Dispensary
state: Ryazanskaya Oblast'
city: Saint-Petersburg
country: Russian Federation
facility: Clinical Rheumatology hospital #25
state: Sankt-Peterburg
city: Saint-Petersburg
country: Russian Federation
facility: North-Western State Medical University named after I.I.Mechnikov
state: Sankt-Peterburg
city: Tula
country: Russian Federation
facility: Tula Regional Clinical Hospital
state: Tul'skaya Oblast'
city: Ulianovsk
country: Russian Federation
facility: GUZ UOKB
state: Ul'yanovskaya Oblast'
city: Petrozavodsk
country: Russian Federation
facility: Karelia Republican Hospital V.A. Baranova
city: Saratov
country: Russian Federation
facility: Regional Clinical Hospital of the Saratov Region
city: Yaroslavl
country: Russian Federation
facility: Research & Practice
city: Zvolen
country: Slovakia
facility: ALBAMED s.r.o.
state: Banskobystrický Kraj
city: Bratislava
country: Slovakia
facility: ROMJAN s.r.o.
state: Bratislavský Kraj
city: Kosice
country: Slovakia
facility: Artromac n.o.
state: Košický Kraj
city: Spisska Nova Ves
country: Slovakia
facility: REUMED s.r.o.
state: Košický Kraj
city: Topolcany
country: Slovakia
facility: LERAM s.r.o.
state: Nitriansky Kraj
city: Partizanske
country: Slovakia
facility: Reumacentrum s.r.o.
state: Trenčiansky Kraj
city: Port Elizabeth
country: South Africa
facility: Netcare Greenacres Hospital
state: Eastern Cape
city: Bloemfontein
country: South Africa
facility: FARMOVS
state: Free State
city: Bloemfontein
country: South Africa
facility: Iatros International
state: Free State
city: Kempton Park
country: South Africa
facility: Clinresco Centres
state: Gauteng
city: Pretoria
country: South Africa
facility: University of Pretoria - Faculty of Health Sciences
state: Gauteng
city: Chatsworth
country: South Africa
facility: Precise Clinical Solutions
state: Kwazulu-Natal
city: Umhlanga
country: South Africa
facility: Netcare Umhlanga Hospital
state: Kwazulu-Natal
city: Cape Town
country: South Africa
facility: Arthritis Clinical Trial Centre
state: Western Cape
city: Stellenbosch
country: South Africa
facility: Winelands Medical Research Centre
state: Western Cape
city: A Coruña
country: Spain
facility: Complejo Hospitalario Universitario A Coruña
state: A Coruña [La Coruña]
city: Santiago de Compostela
country: Spain
facility: Clínica Gaias - Santiago
state: A Coruña [La Coruña]
city: Elche
country: Spain
facility: Hospital General Universitario de Elche
state: Alicante
city: Villajoyosa
country: Spain
facility: Hospital Marina Baixa
state: Alicante
city: Barcelona
country: Spain
facility: Clínica Sagrada Familia
state: Catalunya [Cataluña]
city: Barcelona
country: Spain
facility: Hospital Quiron Barcelona
state: Catalunya [Cataluña]
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
state: Catalunya [Cataluña]
city: Sabadell
country: Spain
facility: Corporació Sanitària Parc Taulí
state: Catalunya [Cataluña]
city: Sant Joan Despí
country: Spain
facility: Consorci Sanitari Integral. Hospital Moisés Broggi, Sant Joan Despí
state: Catalunya [Cataluña]
city: Cordoba
country: Spain
facility: Hu Reina Sofia
state: Córdoba
city: Santiago de Compostela
country: Spain
facility: CHUS - Hospital Clinico Universitario
state: Galicia [Galicia]
city: Fuenlabrada
country: Spain
facility: Hospital Universitario de Fuenlabrada
state: Madrid, Comunidad De
city: Getafe
country: Spain
facility: Hospital Universitario Getafe
state: Madrid, Comunidad De
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro Majadahonda
state: Madrid, Comunidad De
city: Bilbo
country: Spain
facility: Osi Bilbao-Basurto
state: País Vasco
city: Vigo
country: Spain
facility: CHUVI- Hospital do Meixoeiro
state: Pontevedra [Pontevedra]
city: Córdoba
country: Spain
facility: Hospital Quirónsalud Córdoba
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Sevilla
country: Spain
facility: Hospital Quiron Infanta Luisa
city: Basel
country: Switzerland
facility: University Hospital Basel
state: Basel-Stadt
city: St. Gallen
country: Switzerland
facility: Cantonal Hospital St.Gallen
state: Sankt Gallen
city: Fribourg
country: Switzerland
facility: HFR Fribourg - Hôpital Cantonal
city: Eskisehir
country: Turkey
facility: Eskisehir Osmangazi University
state: Eskişehir
city: Stanbul
country: Turkey
facility: Marmara Universitesi Pendik Egitim Arastirma Hastanesi
state: İstanbul
city: Edirne
country: Turkey
facility: Trakya University
city: Istanbul
country: Turkey
facility: Istanbul University Cerrahpasa Medical School Internal Diseases Institute
city: Izmir
country: Turkey
facility: Izmir Katip Celebi Ataturk Egitim Arastirma Hastanesi
city: Konya
country: Turkey
facility: Necmettin Erbakan Meram Medical Fac.
city: Christchurch
country: United Kingdom
facility: Christchurch Hospital
state: Bournemouth
city: Plymouth
country: United Kingdom
facility: Derriford Hospital
state: Devon
city: Torquay
country: United Kingdom
facility: Torbay Hospital
state: Devon
city: Dudley
country: United Kingdom
facility: The Dudley Group NHS Foundation Trust
state: England
city: London
country: United Kingdom
facility: Royal Free London NHS Foundation Trust
state: England
city: Truro
country: United Kingdom
facility: The Royal Cornwall Hospital
state: England
city: Chelmsford
country: United Kingdom
facility: Mid Essex Hospital Services NHS Trust
state: Essex
city: Portsmouth
country: United Kingdom
facility: Queen Alexandra Hospital
state: Hampshire
city: Hull
country: United Kingdom
facility: Hull and East Yorkshire Hospitals NHS Trust
state: Kingston Upon Hull
city: Newcastle upon Tyne
country: United Kingdom
facility: Northumbria Healthcare NHS Foundation Trust
state: North Tyneside
city: Sutton In Ashfield
country: United Kingdom
facility: King's Mill Hospital
state: Nottinghamshire
city: London
country: United Kingdom
facility: Barts Health NHS Trust - Whipps Cross University Hospital
state: Waltham Forest
city: Liverpool
country: United Kingdom
facility: Aintree University Hospital NHS Foundation Trust
city: Wolverhampton
country: United Kingdom
facility: New Cross Hospital
Study officials:
affiliation: Eli Lilly and Company
name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
role: STUDY_DIRECTOR
References: