Clinical trial NCT03242668: Paravertebral Block for Postoperative Analgesia in Thoracoscopic Surgery
Official title: Patient Controlled Paravertebral Analgesia for Video-assisted Thoracoscopic Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain, Postoperative
Keywords: paravertebral block,PVC,PCA
Lead sponsor: Vietnam Military Medical University
Sponsor class: OTHER
Collaborators: name: Nguyen Truong Giang, PhD. Associate Prof.
First posted: 2017-08-08
Enrollment: 30
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: 30 patients, with American Society of Anesthesiologists class I to III risk undergoing elective VATS, aged 32-72 years, scheduled for lung resection surgery , were enrolled in this randomised observer blinded prospective clinical study. Patients who refused to participate, less than 18 years of age, ASA physical status 3 or more, allergy to any of the study drugs, patients having any contraindication for paravertebral block, kyphoscoliosis, presence of acute herpes zoster, chronic pain syndrome, chronic analgesic use and psychiatric disease were excluded from this study.
Primary purpose: TREATMENT

Brief summary: To access the analgesic efficacy of patient controlled thoracic paravertebral analgesia.

Detailed description: The study was carried out on thirty patients who underwent video-assisted thoracic surgery.Paravertebral space was identified by loss of resistance technique under video-assisted inside thoracic space before chest close.Initiated dose of 0.3ml/kg of bupivacaine 0.125%+fentanyl 2 mcg/ml was administered then continued patient-controlled analgesia with background rate 3ml/h, bolus dose 2ml, lockout interval 10 minutes. Postoperative pain was accessed by Visual Analogue Scale at rest and on coughing; monitor the heart rate, blood pressure, respiratory rate, SpO2, arterial blood gas and spirometry in three postoperative consecutive days.

Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists class I to III risk undergoing elective VATS, aged 32-72 years, scheduled for lung resection surgery.

Exclusion Criteria:

* Patients who refused to participate, less than 18 years of age, ASA physical status 3 or more,, allergy to any of the study drugs, patients having any contraindication to placement of PVB, kyphoscoliosis, presence of acute herpes zoster, chronic pain syndrome, chronic analgesic use and psychiatric disease.

Primary outcomes:
measure: VAS score at rest and on coughing
timeFrame: 72 hours
Secondary outcomes:
measure: Analgesia effects on respiratory function
timeFrame: three postoperative consecutive days
measure: Arterial blood gas values
timeFrame: three postoperative consecutive days
measure: The number dermatome inhibition
timeFrame: three postoperative consecutive days
measure: Rescue analgesia
timeFrame: three postoperative consecutive days
measure: Patient's satisfaction
timeFrame: three postoperative consecutive days
Other outcomes:
measure: Side effects and complications
timeFrame: three postoperative consecutive days
measure: Heart rate
timeFrame: three postoperative consecutive days
measure: Blood pressure
timeFrame: three postoperative consecutive days
Locations:
city: Hanoi
country: Vietnam
facility: Vietnam Military Medical University
Study officials:
References: