Clinical trial NCT03689764: Video Game-based Exercise for Persons With Parkinson's Disease
Official title: Effects of Interactive Video Game-based Exercise on Balance of Persons With Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson Disease
Lead sponsor: Taipei Medical University Hospital
Sponsor class: OTHER
First posted: 2018-09-28
Enrollment: 24
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This study assessed the effects of interactive video game-based exercise (IVGB) on balance in persons with Parkinson's disease . Twenty-four patients were randomly allocated to two groups (12 participants per group). Group A underwent IVGB training for the first 6 weeks, with no exercise in the subsequent 6 weeks. Group B had no exercise for the first 6 weeks and then received IVGB training in the subsequent 6 weeks. Both subjective and objective measures were used to determine whether IVGB exercise improves balance function.

Detailed description: The experiments were conducted as a prospective, randomized, single blinded, crossover, 12-week trial. The group A undergoes the IVGB training in the initial 6 weeks (intervention phase), follows by suspended from exercise in the subsequent 6 weeks (control phase). The group B does not received treatment in the first 6 weeks (control phase), and then performs IVGB training in the following 6 weeks (intervention phase). For all participants, The 36-Item Short-Form Health Survey (SF-36), Modified Falls Efficacy Scale (MFES), Berg Balance Scale (BBS), Multidirectional reach test (MDRT) and Maximum step length (MSL) test were assessed at weeks 0, 6, and 12 of the experiment.

Eligibility criteria: Inclusion Criteria:

* medical diagnosis of idiopathic Parkinson's Disease
* independent community ambulatory individuals
* capable of giving informed and written consent (Mini-Mental Status Examination (MMSE)\>23)

Exclusion Criteria:

* the other neurological conditions such as dementia, and stroke, or if they have arthritis, vision impairment,
* cardiovascular disease that impair walking, or diabetic and uremic individuals, or if they were unable to walk without assistance.

Primary outcomes:
measure: Change of Berg Balance Scale (BBS)
timeFrame: 15 minutes/session; measured at weeks 0, 6, and 12 of the experiment
Secondary outcomes:
measure: Change of 36-Item Short-Form Health Survey (SF-36)
timeFrame: 15 minutes/session; measured at weeks 0, 6, and 12 of the experiment
measure: Change of Modified Falls Efficacy Scale (MFES)
timeFrame: 10 minutes/session; measured at weeks 0, 6, and 12 of the experiment
measure: Change of Multidirectional Reach Test (MDRT)
timeFrame: 10 minutes/session; measured at weeks 0, 6, and 12 of the experiment
measure: Change of Maximum Step Length (MSL) test
timeFrame: 10 minutes/session; measured at weeks 0, 6, and 12 of the experiment
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical university Hospital
Study officials:
affiliation: Taipei Medical University Hospital
name: Chien-Hung Lai, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yuan RY, Chen SC, Peng CW, Lin YN, Chang YT, Lai CH. Effects of interactive video-game-based exercise on balance in older adults with mild-to-moderate Parkinson's disease. J Neuroeng Rehabil. 2020 Jul 13;17(1):91. doi: 10.1186/s12984-020-00725-y.