Clinical trial NCT05647655: Value of Transthoracic Ultrasonography (TTU) for Etiological Diagnosis of Acute Dyspnea: Cross Sectional Study
Official title: Value of Transthoracic Ultrasonography (TTU) for Etiological Diagnosis of Acute Dyspnea: Cross Sectional Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Dyspnea
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2022-12-12
Enrollment: 143
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients older than 18 years with acute dyspnea will be included

Brief summary: Evaluating the capability and efficiency of transthoracic ultrasound in attempting to identify the etiology of acute dyspnea.

Detailed description: Acute dyspnea is a frequent challenge for physicians due to having multiple etiologies, leading to difficulty in establishing an accurate diagnosis.

The presence of this symptom is already a predictor of increased mortality and a lot of investigations are required to differentiate between etiologies. Hence, prompt diagnosis is needed to streamline these patients' appropriate management and disposition from the ED.

Transthoracic ultrasound has traditionally been used for the detection of pleural effusion and evaluation of the chest wall, but the indications have been expanded.

The gold standard imaging technique for the majority of pulmonary disorders is high-resolution computed tomography (HRCT), but it has negatives which are:

* hazard of ionizing radiation
* high cost
* being nonportable

Eligibility criteria: Inclusion Criteria:

* Clinical history of acute dyspnea

Exclusion Criteria:

* Subcutaneous emphysema.
* Patients with more than 24 h interval between HRCT and TTU.
* Patients with poor-quality of TTU image.

Primary outcomes:
measure: Differentiate between different etiologies of acute dyspnea
timeFrame: Baseline
Secondary outcomes:
measure: Detect value of transthoracic ultrasound (TTU) in comparison to CT chest.
timeFrame: Baseline
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University hospital
Study officials:
affiliation: Assiut University
name: Ahmed A Elsayed, MBBCH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gargani L, Fontana M, Sicari R, Picano E. [Differential diagnosis of dyspnea: the incremental value of lung ultrasound]. Recenti Prog Med. 2010 Feb;101(2):78-82. Italian.
citation: Baid H, Vempalli N, Kumar S, Arora P, Walia R, Chauhan U, Shukla K, Verma A, Chawang H, Agarwal D. Point of care ultrasound as initial diagnostic tool in acute dyspnea patients in the emergency department of a tertiary care center: diagnostic accuracy study. Int J Emerg Med. 2022 Jun 13;15(1):27. doi: 10.1186/s12245-022-00430-8.
citation: Vitturi N, Soattin M, Allemand E, Simoni F, Realdi G. Thoracic ultrasonography: A new method for the work-up of patients with dyspnea(). J Ultrasound. 2011 Sep;14(3):147-51. doi: 10.1016/j.jus.2011.06.009. Epub 2011 Jun 30.
citation: Li H, Li YD, Zhu WW, Sun LL, Ye XG, Kong LY, Cai QZ, Jiang W, Wang L, Lu XZ. High-Resolution Transthoracic Ultrasonography for Assessment of Pleural Lines in Patients With Dyspnea With CT Comparison: An Observational Study. J Ultrasound Med. 2017 Apr;36(4):707-716. doi: 10.7863/ultra.16.04030. Epub 2017 Jan 27.
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