Clinical trial NCT05771246: Craniofacial Morphology And Sella Turcica Bridging Associated With Third Molar Agenesis.
Official title: Third Molar Agenesis Related To Craniofacial Pattern And Sella Turcica Bridging: A Retrospective Cephalometric Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tooth Agenesis
Lead sponsor: University of Pavia
Sponsor class: OTHER
First posted: 2023-03-16
Enrollment: 400
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients referring to the Unit of Orthodontics and Pediatric Dentistry for orthodontic consultation.

Brief summary: The aim of this retrospective study is to analyze the third molar agenesis with respect to sella turcica bridging and other craniofacial patterns in patients asking for orthodontic consultation. The main question\[s\] it aims to answer are:

* is there a relationship between third molar agenesis and sella turchina bridging?
* is there a relationship between third molar agenesis and craniofacial patterns?

Detailed description: Patients referring for orthodontic consultation at the Unit of Orthodontics and Pediatric Dentistry, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy, will be enrolled for the study according to the inclusion criteria. For each patient, lateral cephalometric radiograph and panoramic radiograph will be performed. For each lateral cephalometric radiograph, a cephalometric tracing will be performed with DeltaDent software (version 2.5.12, Outside Format, Pandino, Italy). Riedel's ANB angle \[Riedel 1952\] has been chosen to determine patients' skeletal class. Steiner's SN\^GoGn angle \[Steiner 1953\] has been chosen to evaluate skeletal divergence. Facial axis (BaNa\^CCGn), Lower Facial Height (LFH) and mandibular plan angle (FH\^GoMe) from Rickett's analysis \[Rickett's 1961\] have been adopted to determine facial growth. According to Jaraback's cephalometric analysis \[Jaraback 1985\], saddle angle, articular angle, upper gonial angle, lower gonial angle will be measured to assess the growth pattern. Linear measurements of sella depth, sella diameter and interclinoid distance \[Silverman 1957; Kisling 1966\] will be calculated. Linear regressions between craniofacial patterns, sella turcica bridging and third molar agenesis will be calculated. A control group with no third molar agenesis will be provided.

Eligibility criteria: Inclusion Criteria:

* G stage of Demirjian's classification for third molar maturation or absence of third molar germs
* Patients with one lateral cephalometric digital radiograph executed in Natural Head Position (patients were asked to keep the teeth in contact and the lips relaxed).
* Patients with panoramic radiograph;

Exclusion Criteria:

* Ascertained previous surgical extraction/s of third molar/s
* Orthopedic/orthodontic therapy
* Orthognathic surgery.

Primary outcomes:
measure: Linear regression between third molar agenesis and ANB
timeFrame: Baseline
measure: Linear regression between third molar agenesis and Interclinoid Distance
timeFrame: Baseline
measure: Linear regression between third molar agenesis and Sella Depth.
timeFrame: Baseline
measure: Linear regression between third molar agenesis and Sella Diameter
timeFrame: Baseline
measure: Linear regression between third molar agenesis and Sn^GoGn.
timeFrame: Baseline
measure: Linear regression between third molar agenesis and ArGo^GoGn
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Pavia
country: Italy
facility: Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia
state: Lombardy
Study officials:
affiliation: University of Pavia
name: Andrea Scribante, DDS, Ms, PhD
role: PRINCIPAL_INVESTIGATOR
References: