Clinical trial NCT05525403: The Effects of Fatigue on Exercise-Induced Hypoalgesia During a Dynamic Resistance Exercise
Official title: The Effects of Fatigue on Exercise-Induced Hypoalgesia During a Dynamic Resistance Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: University of Central Florida
Sponsor class: OTHER
First posted: 2022-09-01
Enrollment: 31
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The primary purpose of this study is to compare immediate changes in pain sensitivity (pressure pain threshold) during quiet rest, low fatigue exercise, and high fatigue exercise.

Detailed description: Participants will attend three sessions. Participants will fill out questionnaires, undergo pain sensitivity testing, and be randomly assigned to complete a high and low fatigue exercise on either the second or third session. During the exercise, participants will complete three sets of a single leg knee extension exercise with weight equivalent to 50% of their 1 repetition maximum until they report either a high or low fatigue level. Immediately before and after each set, the research team will examine immediate changes in sensitivity to pressure (pressure pain threshold).

Eligibility criteria: Inclusion Criteria:

* Pain-free
* 18-60 years old
* Participant can appropriately perform the knee extension exercise (assessed during screening)

Exclusion Criteria:

* Non-English speaking
* Regular use of prescription pain medications
* Current or history of chronic pain condition
* Currently taking blood-thinning medication
* Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions
* Any contraindication to the application of ice, such as: uncontrolled hypertension (blood pressure over 140/90 mmHg), cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, circulatory compromise
* Known presence of cardiovascular, pulmonary, or metabolic disease
* Current use of tobacco products
* Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
* Surgery, injury, or fracture to the lower back or lower extremity within the past 6 months

Primary outcomes:
measure: Change in Pressure Pain Threshold
timeFrame: Change from baseline immediately after exercise
Secondary outcomes:
measure: Temporal Summation
timeFrame: Baseline, pre exercise
measure: Heat Pain Threshold
timeFrame: Baseline, pre exercise
measure: Conditioned Pain Modulation
timeFrame: Baseline, pre exercise
measure: International Physical Activity Questionnaire Short Form
timeFrame: Baseline, pre exercise
measure: Pittsburgh Sleep Quality Index
timeFrame: Baseline, pre exercise
measure: Pain Catastrophizing Scale
timeFrame: Baseline, pre exercise
measure: Fear of Pain Questionnaire 9
timeFrame: Baseline, pre exercise
measure: Pain Anxiety Symptom Scale
timeFrame: Baseline, pre exercise
measure: Brief Resilience Scale
timeFrame: Baseline, pre exercise
measure: Preference for and Tolerance of the Intensity of Exercise Questionnaire
timeFrame: Baseline, pre exercise
Other outcomes:
measure: 1-repetition maximum testing
timeFrame: Baseline, pre exercise
Locations:
city: Orlando
country: United States
facility: University of Central Florida
state: Florida
Study officials:
affiliation: University of Central Florida
name: Abigail Wilson
role: PRINCIPAL_INVESTIGATOR
References: