Clinical trial NCT04887610: Factors That Influence Blood Vessel Regulation During Exercise in Humans
Official title: Factors That Influence Blood Vessel Regulation During Exercise in Humans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ischemic Preconditioning
Dietary Exposure
Lead sponsor: University of Guelph
Sponsor class: OTHER
First posted: 2021-05-14
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study will examine two separate interventions: 1) the effects of ischemic preconditioning or 2) a high fat meal on the capacity of the brachial artery to overcome sympathetic activation and dilate during exercise (also known as functional sympatholysis). Participants will be asked to complete rhythmic handgrip exercise with and without the application of -20 mmHg lower body negative pressure to increase sympathetic activation. Doppler ultrasound will be used to continuously measure brachial artery blood flow. Participants will complete the handgrip exercise and lower body negative pressure before and after the applications of each interventions. Participants may elect to only complete one intervention rather than complete both protocols. Intervention one is active or control ischemic preconditioning. Intervention two is high or low fat meals.


Eligibility criteria: Inclusion Criteria:

* 18 years or older
* Healthy

Exclusion Criteria:

* History of smoking (tobacco or cannabis), defined as any smoking within the past 3 months
* Diagnosed cardiovascular or metabolic disease(s)
* Recent musculoskeletal injury handgrip exercise
* Prescription of chronic medications other than oral contraceptives
* History of hypertension or presence of arrhythmia

Primary outcomes:
measure: Forearm blood flow
timeFrame: Baseline - Immediately before active and control interventions
measure: Forearm blood flow
timeFrame: Immediately after active and control interventions (IPC only)
measure: Forearm blood flow
timeFrame: 1 hour after active and control interventions (Diet intervention only)
measure: Forearm blood flow
timeFrame: 2 hours after active and control interventions (Diet intervention only)
measure: Forearm blood flow
timeFrame: 3 hours after active and control interventions (Diet intervention only)
measure: Forearm vascular conductance
timeFrame: Baseline - Immediately before active and control interventions
measure: Forearm vascular conductance
timeFrame: Immediately after active and control interventions (IPC only)
measure: Forearm vascular conductance
timeFrame: 1 hour after active and control interventions (Diet intervention only)
measure: Forearm vascular conductance
timeFrame: 2 hours after active and control interventions (Diet intervention only)
measure: Forearm vascular conductance
timeFrame: 3 hours after active and control interventions (Diet intervention only)
Secondary outcomes:
measure: Blood pressure
timeFrame: Baseline - Immediately before active and control interventions
measure: Blood pressure
timeFrame: Immediately after active and control interventions (IPC only)
measure: Blood pressure
timeFrame: 1 hour after active and control interventions (Diet intervention only)
measure: Blood pressure
timeFrame: 2 hours after active and control interventions (Diet intervention only)
measure: Blood pressure
timeFrame: 3 hours after active and control interventions (Diet intervention only)
measure: Heart rate
timeFrame: Baseline - Immediately before active and control interventions
measure: Heart rate
timeFrame: Immediately after active and control interventions (IPC only)
measure: Heart rate
timeFrame: 1 hour after active and control interventions (Diet intervention only)
measure: Heart rate
timeFrame: 2 hours after active and control interventions (Diet intervention only)
measure: Heart rate
timeFrame: 3 hours after active and control interventions (Diet intervention only)
Other outcomes:
Locations:
city: Guelph
country: Canada
facility: University of Guelph - Human Cardiovascular Physiology Laboratory
state: Ontario
Study officials:
References: