Clinical trial NCT05674084: Vasopressor Support, Mean Arterial Pressure and Capillary Refill Time in Critically Ill Patients
Official title: Influence of Vasopressor Support and Mean Arterial Pressure on Capillary Refill Time Values in Critically Ill Patients: Prospective, Observational Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Critical Illness
Keywords: capillary refill time
norepinephrine
epinephrine
argipressin
dobutamine
mean arterial pressure
Lead sponsor: Medical University of Silesia
Sponsor class: OTHER
First posted: 2023-01-06
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult critically ill patients requiring vasopressor support will be included in the study. Over the course of the ICU hospitalization, a maximal number of 5 CRT measurements will be made.

Brief summary: The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in crtically ill patients. The main questions it aims to answer are:

* How do vasopressor drugs determine CRT value
* How does mean arterial pressure (MAP) determine CRT value
* How often CRT value is normal (\< 3 sec) despite hypotensive MAP (\<65 mmHg)

Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value.

Detailed description: The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in critically ill patients. The main questions it aims to answer are:

* How does norepinephrine dose influence CRT value
* How does epinephrine dose influence CRT value
* How does argipressin dose influence CRT value
* How does dobutamine dose influence CRT value
* How does mean arterial pressure (MAP) determine CRT value
* How often CRT value is normal (\< 3 sec) despite hypotensive MAP (\<65 mmHg)

Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value. CRT will be a dependent variable. Independent variables will be as follows: age, MAP, norepinephrine dose, epinephrine dose, argipressin dose, dobutamine dose.

CRT measurements will be performed in a standarized rigor (light, chronometer, pressure and ambient temperature will be the same in all patients)

Eligibility criteria: Inclusion Criteria:

* critical illness requiring vasopressor support
* invasive blood pressure monitoring

Exclusion Criteria:

* finger distal phalanx not available
* patient in a room of suboptimal ambient temperature

Primary outcomes:
measure: Effect of norepinephrine dose on CRT value
timeFrame: Through study completion, an average of 1 year
measure: Effect of mean arterial pressure on CRT value
timeFrame: Through study completion, an average of 1 year
Secondary outcomes:
measure: Effect of epinephrine dose on CRT value
timeFrame: Through study completion, an average of 1 year
measure: Effect of argipressin dose on CRT value
timeFrame: Through study completion, an average of 1 year
measure: Effect of dobutamine dose on CRT value
timeFrame: Through study completion, an average of 1 year
measure: CRT value in MAP <65 mmHg
timeFrame: Through study completion, an average of 1 year
Other outcomes:
Locations:
city: Katowice
country: Poland
facility: University Clinical Center named after prof. K. Gibiński of the Medical University of Silesia in Katowice
state: Silesia
Study officials:
affiliation: Medical University of Silesia
name: Łukasz Krzych, Professor
role: STUDY_CHAIR
References:
citation: McGuire D, Gotlib A, King J. Capillary Refill Time. 2023 Apr 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK557753/
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