Clinical trial NCT01580150: Effects of Berries on Post-meal Blood Sugar
Official title: Effects of Berries on Postprandial Glycemic Responses to Sucrose and Starch
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Blood Glucose, Postprandial
Blood Insulin, Postprandial
Hyperglycemia
Keywords: Berries
Starch
Sucrose
Glucose
Insulin
Postprandial
Lead sponsor: University of Eastern Finland
Sponsor class: OTHER
First posted: 2012-04-18
Enrollment: 20
Minimum age (years): 25
Maximum age (years): 69
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to investigate whether berries are effective in lowering blood glucose and insulin responses to meals containing starch or sucrose.

Detailed description: Berries are rich sources of various polyphenols which may be beneficial in the regulation of blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates and thereby suppress postprandial glycemia. However, current evidence on the effects of berries on postprandial glycemic responses in humans is limited.

The purpose of this study is to investigate the effects of berries on postprandial glycemic responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists of five substudies each of which includes 2-4 meals with different berry species typically consumed in Finland and a reference meal without berries. The following combinations of carbohydrates and berries are studied:

* Studies 1-2: white wheat bread (starch) is consumed with several berry species
* Study 3: white wheat bread or rye bread is consumed with a mixture of berries
* Study 4: sugar (sucrose) is consumed with berries and berry nectars
* Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries and berry nectar.

Eligibility criteria: Inclusion Criteria:

* BMI 20-28 kg/m2
* normal fasting plasma glucose

Exclusion Criteria:

* Smoking
* Diabetes or other chronic disease
* Antibiotic medication within the past 3 months
* Blood donation within the past month

Primary outcomes:
measure: Plasma glucose
timeFrame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal
measure: Plasma insulin
timeFrame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal
Secondary outcomes:
measure: Plasma free fatty acids
timeFrame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal
Other outcomes:
Locations:
city: Kuopio
country: Finland
facility: University of Eastern Finland
Study officials:
affiliation: Senior Scientist
name: Riitta Törrönen, Dr
role: PRINCIPAL_INVESTIGATOR
References:
citation: Torronen R, Kolehmainen M, Sarkkinen E, Poutanen K, Mykkanen H, Niskanen L. Berries reduce postprandial insulin responses to wheat and rye breads in healthy women. J Nutr. 2013 Apr;143(4):430-6. doi: 10.3945/jn.112.169771. Epub 2013 Jan 30.
citation: Torronen R, Kolehmainen M, Sarkkinen E, Mykkanen H, Niskanen L. Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women. Am J Clin Nutr. 2012 Sep;96(3):527-33. doi: 10.3945/ajcn.112.042184. Epub 2012 Aug 1.