louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01583855: Manual vs Amigo SmartTouch Atrial Fibrillation Study
Official title: Manual vs Amigo SmartTouch Atrial Fibrillation Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Atrial Fibrillation
Keywords: Remote catheter ablation
Atrial fibrillation
Lead sponsor: University of Leicester
Sponsor class: OTHER
First posted: 2012-04-24
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Atrial fibrillation is a common form of heart rhythm disturbance that for some patients is treated by catheter ablation (making an ablation lesion or burn inside the heart using a fine wire (catheter)). A new system for manipulating the catheters has recently been introduced into clinical practice (the Amigo Remote Catheter System (RCS)). This trial is designed to answer two primary questions: a) is the contact force (the force with which the catheter comes into contact with the heart) any different using the RCS to manual techniques,and b)are the resulting ablation lesions within the heart any different in terms of the volume and contiguity of the lesions produced. Additionally the investigators aim to determine how the two techniques compare in success (the proportion of patients whose heart rhythm disturbance is corrected by the procedure).

Detailed description: The trial aims to recruit 50 patients, randomised into two groups, to have ablation for atrial fibrillation performed either using the RCS, or manually. Contact force information will be collected during the procedure, but the operators will be blinded to this information. Patients will have follow-up to include post-procedural cardiac magnetic resonance imaging and ambulatory electrocardiograms.

Eligibility criteria: Inclusion Criteria:

* atrial fibrillation
* scheduled for catheter ablation

Exclusion Criteria:

* contraindication to magnetic resonance imaging
* pregnancy
* life expectancy of less than six months
* participation in another trial that would conflict with this trial

Primary outcomes:
measure: Contact force delivered
timeFrame: Contact force information collected at the time of the procedures
Secondary outcomes:
measure: Quantity and contiguity of ablation lesions
timeFrame: 3 months post procedure
measure: Recurrence of atrial fibrillation
timeFrame: 1 year
Other outcomes:
Locations:
city: Leicester
country: United Kingdom
facility: Glenfield Hospital, Groby Road
Study officials:
affiliation: University of Leicester, UK
name: G Andre Ng, MBChB, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06431555: Magnetic Resonance Lung Function Imaging Study of Pulmonary Fibrosis Combined With Emphysema Syndrome
Official title: Magnetic Resonance Lung Function Imaging Study of Pulmonary Fibrosis Combined With Emphysema Syndrome
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Using Functional Lung MRI to Explore Pulmonary Perfusion Changes in Patients With Pulmonary Fibrosis and Emphysema Syndrome
Lead sponsor: Beijing Chao Yang Hospital
Sponsor class: OTHER
First posted: 2024-05-28
Enrollment: 55
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: (1) Chest HRCT shows emphysema mainly distributed in the upper lung field, manifesting as wallless or thin-walled (wall thickness \<1 mm) low-transmittance areas with clear boundaries with normal tissue, or multiple bullae (diameter \> 1 cm), and the emphysema area/total lung volume is ≥10%; (2) interstitial pulmonary fibrosis mainly distributed in the lower lung field and subpleura, manifesting as honeycomb shadow or grid shadow, and the lung structure is destroyed , may be accompanied by traction bronchiectasis, ground glass opacities and consolidation opacities.

Brief summary: This study intends to use magnetic resonance pulmonary function imaging technology to explore imaging markers for early diagnosis of patients with CPFE. Through baseline, 6-month and 12-month follow-up examinations, the changes in magnetic resonance pulmonary function in patients with CPFE and their correlation with disease progression were explored.


Eligibility criteria: Inclusion Criteria:

* (1) Chest HRCT shows emphysema mainly distributed in the upper lung field, manifesting as wallless or thin-walled (wall thickness \<1 mm) low-transmittance areas with clear boundaries with normal tissue, or multiple bullae (diameter \> 1 cm), and the emphysema area/total lung volume is ≥10%; (2) interstitial pulmonary fibrosis mainly distributed in the lower lung field and subpleura, manifesting as honeycomb shadow or grid shadow, and the lung structure is destroyed , may be accompanied by traction bronchiectasis, ground glass opacities and consolidation opacities.

Exclusion Criteria:

* (1) Refusal to sign the informed consent form; (2) MRI contraindications (implanted pacemaker/defibrillator, claustrophobia, or any clinical condition that prohibits longer MRI examinations).

Primary outcomes:
measure: perfusion defect percentage
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Chaoyang Hospital
state: Beijing
Study officials:
affiliation: Beijing Chao Yang Hospital
name: Shumin Wang, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT02006355: Continuous Local Anesthesia Versus Continuous Femoral Nerve Bloc After Total Knee Arthroplasty: Impact on Mean Discharge Aptitude Delay
Official title: Continuous Local Anesthesia Versus Continuous Femoral Nerve Bloc After Total Knee Arthroplasty: Impact on Mean Discharge Aptitude Delay
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Total Knee Arthroplasty
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2013-12-10
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims at comparing continuous local anesthesia and femoral nerve bloc for total knee arthroplasty in terms of post-operative recovery.


Eligibility criteria: Inclusion Criteria:

* Total knee arthroplasty
* Age \> 18 years with social security covering.
* Written informed consent

Exclusion Criteria:

* Age \< 18 years
* ASA Physical Status \> III
* Body weight \< 50 kg
* Latex or silver allergy.
* Loco-regional anesthesia contraindication
* Chronic anticoagulant, corticoid or pain treatment.
* Rivaroxaban or enoxaparin contraindication
* Communication issues
* Patient under guardianship
* Pregnant or breast-feeding patient

Primary outcomes:
measure: Discharge ability time period
timeFrame: Participants will be followed for the duration of hospital stay, an expected average of 10 days
Secondary outcomes:
Other outcomes:
Locations:
city: Illkirch-Graffenstaden
country: France
facility: CCOM-Hôpitaux Universitaires de Strasbourg
Study officials:
affiliation: Hôpitaux Universitaires de Strasbourg
name: Jean-Yves JENNY, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04751214: New Technique For Laparoscopic Appendicectomy
Official title: Zaragoza Technique For Laparoscopic Appendicectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Appendicitis Acute
Lead sponsor: Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Sponsor class: OTHER_GOV
First posted: 2021-02-12
Enrollment: 148
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: At the "General Ignacio Zaragoza" Regional Hospital, of the Institute of Social Security and Services for State Workers (ISSSTE), since July 2002, a new laparoscopic appendectomy technique has been performed by a surgical group.

Brief summary: Introduction: Appendectomy is one of the most frequent emergency surgical procedures, currently with a preference for laparoscopic management worldwide. Objective: To report a new laparoscopic appendectomy technique and its results. Material and methods: study of patients with a diagnosis of appendicitis who are managed laparoscopically. In a total 1063 patients, 148 were operated on with the Zaragoza technique during the period from January 2002 to December 2018. The technique consists of making a window in the appendicular base between the meso and the appendicular wall, two prolene or silk sutures are placed, and the cecal appendix is cut between the two sutures, finally the mesoappendix is sectioned with a harmonic scalpel or bipolar clamp.

Detailed description: this is a retrospective study based on files

Eligibility criteria: Inclusion Criteria:

* patients with a diagnosis of appendicitis who are managed laparoscopically.

Exclusion Criteria:

* Less than 18 year old

Primary outcomes:
measure: success of surgery
timeFrame: 2002-2018
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04298814: Safety Related Factors of Endotracheal Intubation in Patients With Severe Covid-19 Pneumonia
Official title: Analysis of Safety Related Factors of Endotracheal Intubation in Patients With Severe Covid-19 Pneumonia
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: COVID-19
Endotracheal Intubation
Lead sponsor: Tongji Hospital
Sponsor class: OTHER
First posted: 2020-03-06
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Severe and critical patients with covid-19 pneumonia in urgent need of tracheal intubation

Brief summary: To analyze the intubation with severe covid-19 pneumonia, the infection rate of anesthesiologist after intubation, and summarizes the experience of how to avoid the infection of anesthesiologist and ensure the safety of patients with severe covid-19 pneumonia.

Detailed description: To analyze the intubation time, intubation condition, intubation process, intubation times and success rate of patients with severe covid-19 pneumonia, the infection rate of anesthesiologist after intubation, the degree of respiratory improvement and survival rate of patients, and summarizes the experience of how to avoid the infection of anesthesiologist and ensure the safety of patients with severe covid-19 pneumonia.

Eligibility criteria: Inclusion Criteria:

* Wuhan residents;
* novel coronavirus pneumonia was found to be characterized by fever and cough. Laboratory tests revealed leukocyte or lymphocyte decrease, chest CT examination showed viral pneumonia changes, and was diagnosed as COVID-19 pneumonia according to the national health and Health Committee's new coronavirus pneumonia diagnosis and treatment plan (trial version fifth Revision).
* Severe and critical patients with covid-19 pneumonia in urgent need of tracheal intubation;
* Sign informed consent.

Exclusion Criteria:

* Suspected patients with covid-19 pneumonia;
* Patients who need emergency endotracheal intubation due to other causes of respiratory failure;
* The family refused to sign the informed consent.

Primary outcomes:
measure: Success rate of intubation
timeFrame: the time span between 1hour before intubation and 24h after intubation
measure: Infection rate of Anesthesiologist
timeFrame: the time span between 1hour before intubation and 14days after intubation
Secondary outcomes:
measure: Extubation time
timeFrame: the time span between 1hour before intubation and 30days after intubation
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Tongji Hospital
state: Hubei
Study officials:
affiliation: Tongji Hospital
name: Aijun XU, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03356314: Prenatal Ultrasound Screening of Intestinal Malrotation With a Higher Risk of Volvulus
Official title: Prenatal Ultrasound Screening of Intestinal Malrotation With a Higher Risk of Volvulus: Value of The Relative Position of The Superior Mesenteric Artery and Vein. Future of the Children With an Antenatal Malrotation Suspicion
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intestinal Malrotation
Keywords: superior mesenteric artery
superior mesenteric vein
intestinal malrotation
volvulus
pregnant women
mesenteric vessels position
postnatal diagnosis
prophylactic surgery
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2017-11-29
Enrollment: 9000
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All pregnant women

Brief summary: The aim of this study was to assess the value of an unusual relative position of the superior mesenteric artery (SMA) and vein (SMV) to screen intestinal malrotation with a higher risk of volvulus.

First, feasibility study was done to prove the reproducibility of ultrasound in diagnosis of anormal mesenteric vessels position.

A systematic screening of the mesenteric vessels position was performed at each pregnancy required ultrasound.

When the fœtus had an unusual position of the mesenteric vessels, an MRI was suggested between 30 and 35 GA and the couple met the pediatric surgery team.

Few days after birth, an abdominal ultrasound was achieved as well as a barium enema and upper gastrointestinal. If there were a hight probability of malrotation with a higher risk of volvulus, a prophylactic surgery was proposed. The children were flollowed up during 1 year.


Eligibility criteria: Inclusion criteria:

* pregnant women
* second or third trimester ultrasound.

Exclusion criteria:

* fœtal ultrasound anomaly

Primary outcomes:
measure: Reproducibility of ultrasound in the diagnosis of the abnormal position of the mesenteric vessels
timeFrame: 1 day (Pre and post natal ultrasound)
measure: Antenatal screening of intestinal malrotation
timeFrame: 1 day (Pre and post natal ultrasound)
measure: Future of the children with an ante natal diagnosis of intestinal malrotation
timeFrame: 1 year after birth
Secondary outcomes:
measure: Produce ante and postnatal strategy facing a situation of mesenteric vessels malposition.
timeFrame: 1 day (During Pregnancy)
measure: Produce ante and postnatal strategy facing a situation of mesenteric vessels malposition.
timeFrame: 1 day (after delivery)
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: florent FUCHS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02300714: Fluoroscopically-guided Epidural Block in the Midthoracic Region: A Comparison of Anterioposterior Versus Oblique View Approach
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Low Back Pain Requiring Epidural Injection
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2014-11-25
Enrollment: 2
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: A comparison of anterioposterior versus oblique view approach method for fluoroscopically-guided epidural block in the midthoracic region. The investigators evaluate differences on total radiation time and technical feasibility between anterioposterior and oblique view approach method.


Eligibility criteria: Inclusion Criteria:

* Adult patients who were scheduled for the transforaminal epidural injection in midthoracic region (T5-T7)

Exclusion Criteria:

* Local anesthetic allergy, coagulopathy

Primary outcomes:
measure: Total radiation exposure time
timeFrame: immediately ≤1 sec after the confirmation of successful epidural injection
Secondary outcomes:
measure: The number of the needle readjustments
timeFrame: immediately ≤1 sec after the confirmation of successful epidural injection
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Study officials:
References:
Clinical trial NCT02711514: Femoral Artery Crossover Rates in 1000 Consecutive Radial Cath Labs Procedures.
Official title: Femoral Artery Crossover Rates of 1000 Consecutive Radial (or Ulnar) Artery Procedures in the Cardiac Cath Lab for Diagnostic Cardiac Catheterizations and/or Percutaneous Coronary Interventions
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Retrospective Review
Lead sponsor: Miami Cardiac and Vascular Institute
Sponsor class: OTHER
First posted: 2016-03-17
Enrollment: 10
Sex: ALL
Minimum age (years): 35
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1000 Consecutive Patients who underwent Radial (or Ulnar) Artery Procedures in the Cardiac Cath Lab for Diagnostic Cardiac Catheterizations and/or Percutaneous Coronary Interventions.

Brief summary: Comparison of Crossover rates of Radial Cardiac Catheterizations and/or PCIs into femoral vs published literature

Detailed description: A retrospective review of 1000 consecutive Radial or Ulnar Cardiac Catheterizations and/or Percutaneous Coronary Interventions performed in our Institute by one single operator could provide us with the cross over rates to femoral interventions. In this manner these rates could be compared to the published rates of other institutions benchmarking our techniques with the outcomes for such interventions.

Eligibility criteria: Inclusion Criteria:

* Patients coming to the emergency room requiring Diagnostic Cardiac Catheterizations and/or Percutaneous Coronary Interventions

Exclusion Criteria:

* Cardiac Tamponade
* Cardiogenic Shock

Primary outcomes:
measure: Crossover rate from Radial to Femoral access
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Miami
country: United States
facility: Miami Cardiac and Vascular Institute
state: Florida
Study officials:
affiliation: Director Structural Heart BHSF
name: Ramon Quesada, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01997814: Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis
Official title: EFFECT OF SRP WITH ADJUNCTIVE THERAPY OF HERBAL IMMUNOMODULATORS ON THE SERUM C REACTIVE PROTEIN (CRP) LEVELS & CLINICAL PARAMETERS IN CHRONIC PERIODONTITIS PATIENTS - A RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED, CLINICAL TRIAL.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Chronic Periodontitis
Keywords: Herbal medicine,
Host modulation therapy,
Periodontitis,
Meta-analysis,
Scaling and root planing.
Lead sponsor: Tatyasaheb Kore Dental College
Sponsor class: OTHER
First posted: 2013-11-28
Enrollment: 60
Sex: ALL
Minimum age (years): 30
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Addition of systemic herbal immunomodulators with scaling \& root planing (SRP) may enhance the therapeutic result of Chronic Periodontitis owing to host modulation \& anti-inflammatory properties. If proven, herbal immunomodulators can be used as an adjunct to SRP.


Eligibility criteria: Inclusion Criteria:

1. Patients within age group of 30 to 55 years.
2. Systemically healthy individuals.
3. Patients with chronic generalized periodontitis (moderate and severe) according to Center of Disease Control (CDC) working group, 2007 criteria

Exclusion Criteria:

1. Patients with systemic illnesses (i.e., diabetes mellitus, cancer, human immunodeficiency syndrome, bone metabolic diseases, or disorders that compromise wound healing, radiation, or immunosuppressive therapy),
2. Smoking,
3. Chronic alcoholics,
4. Pregnancy or lactation,
5. Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), steroids or antibiotics / antimicrobials within January 2012 to Jun 2013,
6. Confirmed or suspected intolerance to herbal medicines,
7. Periodontal therapy done within the january 2012 to Jun 2013.

Primary outcomes:
measure: Change from baseline in serum CRP levels at 3 weeks and 6 weeks
timeFrame: baseline, 3 weeks, 6 weeks
measure: changes from baseline in Pocket Depth (PD) at 3 weeks and 6 weeks.
timeFrame: baseline, 3 weeks and 6 weeks
measure: changes from baseline in Clinical Attachment Level (CAL) at 3 weeks and 6 weeks.
timeFrame: baseline, 3 weeks and 6 weeks
Secondary outcomes:
measure: Changes from baseline in Gingival Index (GI) at 3 weeks and 6 weeks
timeFrame: baseline, 3 weeks and 6 weeks
measure: change from baseline in Plaque Index (PI) at 3 weeks and 6 weeks
timeFrame: baseline, 3 weeks and 6 weeks
measure: Changes from baseline in Oral Hygiene Index Simplified (OHIS) at 3 weeks and 6 weeks.
timeFrame: baseline, 3 weeks and 6 weeks
measure: Changes from baseline in Sulcus Bleeding Index (SBI) at 3 weeks and 6 weeks
timeFrame: baseline, 3 weeks and 6 weeks
Other outcomes:
Locations:
city: Kolhapur
country: India
facility: Tatyasaheb Kore Dental College and Research Centre, New Pargaon
state: Maharashtra
Study officials:
affiliation: Post Graduate Student
name: Girish D Deore, BDS
role: PRINCIPAL_INVESTIGATOR
References: