Clinical trial NCT05838950: HIIT Effects on Cardiometabolic Health
Official title: Detraining Effect of Short-term HIIT on Cardiometabolic Risk in Young Adults With Obesity
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Obesity
Cardiovascular Diseases
Metabolic Disease
High-intensity Interval Training
Keywords: HIIT
Detraining effects
Cardiometabolic disease
Obesity
Young adults
Lead sponsor: Syracuse University
Sponsor class: OTHER
First posted: 2023-05-03
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-rest ratios: 1) HIIT-A, 2) HIIT-B, 3) HIIT-C, and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of a running based HIIT program over a 2-week training period. Pre-clinical markers of cardiovascular disease, blood lipids and fasting glucose will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the training cessation (i.e., measure for detraining effect). All measurements will be performed three days before the training program and three days after the intervention to avoid the effect of the last training session. Afterwards, the detraining test will be measured 2 weeks post intervention.

Detailed description: Introduction: High-intensity interval training (HIIT) compared with other traditional exercise regimens has shown to be effective in improving cardiometabolic health (as measured by lipids, blood pressure \[BP\], insulin sensitivity, pulse wave velocity) in overweight and obese adults. By knowing which HIIT protocol is more efficacious in improving markers of cardiometabolic disease, exercise physiologists, researchers and clinicians can properly prescribe exercise medicine to obese young adults and possibly prevent disease progression. Therefore, the primary aim of the present research is to compare the effects of 3 different HIIT protocols compared with a control group on cardiometabolic health improvement in young adults with obesity.

Participants: Participants will be randomly assigned to one of the following three groups : 1) HIIT-A (5:25 s; 1:5 ratio), 2) HIIT-B (10:50 s; 1:5 ratio), 3) HIIT-C (20:100 s; 1:5 ratio), and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of running-based HIIT programs over a 2-week training period. The variables will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the TC (i.e., measure for detraining effect).

High-Intensity Interval Training (six sessions over 2 weeks): Heart rate will be recorded - while performing a sprint running based on the wood court. The HIIT intensity will be set at 90% of the fastest baseline with 40 repetitions of 5-seconds work time, 20 repetitions of 10-seconds work time, or 10 repetitions of 20-seconds work time. All participants will perform one bout of sprint running for 5-, 10-, or 20- seconds followed by 25-second, 50-second, or 100-seconds resting. The supervisor will verbally encourage the running to inspire the sprint at "all-out" intensity. Note that a total of 200-seconds workout time is required per session.

Eligibility criteria: Inclusion Criteria:

* Young adults with obesity (Age 18 to 25 years old, BMI ≥ 30 kg/m2).

Exclusion Criteria:

* Syndromic obesity; 1) Any clinical symptoms including cognitive delay, 2) abnormalities in body structure(s), 3) organ-specific abnormalities (kidney, liver failure, excessive eating, and/or other signs of hypothalamic dysfunction such as fatigue, weakness and/or lack of interest in activities.
* Taking weight loss medication(s)
* Currently enrolled (or within previous 6 months) in a weight loss program;
* An underlying disease/medications (steroids, second generation psychotropic agents, hormonal contraception, statins, antihypertensive and antidiabetic medications) that could influence carbohydrate or lipid metabolism.
* Presence of cardiac pacemaker.
* Current or anticipated participation in another research that would interfere with any of the outcomes.
* Current or anticipated pregnancy.

Primary outcomes:
measure: Height
timeFrame: Baseline
measure: Weight
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Body mass index
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Percentage body fat
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Fat mass
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Lean mass
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Systolic blood pressure
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Diastolic blood pressure
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Mean arterial pressure
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Flow-mediated dilation
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Carotid-femoral Pulse Wave Velocity (cPWV)
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Total cholesterol
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: LDL-C
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: HDL-C
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Triglycerides
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
measure: Glucose
timeFrame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Secondary outcomes:
Other outcomes:
Locations:
city: Syracuse
country: United States
facility: Women's Building
state: New York
Study officials:
affiliation: Syracuse University, Departments of Exercise Science
name: Joon Young Kim, Ph.D
role: PRINCIPAL_INVESTIGATOR
References: