Clinical trial NCT06539650: Neural Adaptations to a Single Session of Metronome-Paced Strength Training
Official title: Neural Adaptations to a Single Session Metronome-Paced Strength Training: Insights From Neuroscience and Human Movement Variability
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Healthy
Keywords: Motor Control
Neuroscience
Neural Adapatations
Transcranial Magnetic Stimulation
Dynamic Systems
Metronome Paced Strength Training
Lead sponsor: Egas Moniz - Cooperativa de Ensino Superior, CRL
Sponsor class: OTHER
Collaborators: name: Fundação para a Ciência e a Tecnologia
First posted: 2024-08-06
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of the study is to investigate the effects of incorporating variability within a single session of Resistance Training (RT) methods on the neural adaptations along the corticospinal tract and on neuromuscular function. The literature suggests that RTis one of the most common modalities to enhance and restore muscle function and its practice results in adaptation in neural and morphological adaptations. Moreover, it is also known that muscle contraction relies on the coordination and regulation of the descending neural drive from the motor cortex to the motoneurons and from the motoneurons to the muscles. However, traditional RT programs tend not to address this motor control dimension. Recent approaches such as metronome paced strength training have been used to cover this motor control dimension through a greater control and consciousness of movement. However, this methodology tends not to incorporate the inherent variability and complex, fractal-like fluctuations that characterize human movement. The investigators propose that incorporating variability through a fractal-like metronome approach will speed up the neural adaptations which will be useful in injury rehab


Eligibility criteria: Inclusion Criteria:

* healthy males
* aged between 18 and 40 years

Exclusion Criteria:

* Neurologic conditions;
* Lower limb disabilities or disease;
* Not able to provide informed consent;
* Have an implanted device (e.g. pacemakers) or any metal in the body;
* Medication advised against the application of Transcranial Magnetic Stimulation;
* History/family history of seizures, brain lesions or head trauma, neurological or psychiatric diseases, epilepsy, migraine

Primary outcomes:
measure: Corticospinal Excitability (CSE) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions
timeFrame: PRE (before intervention), POST (immediately after the intervention), POST 30 (30 minutes after the intervention), POST 60 (60 minutes after the intervention)
measure: Short-Interval Intracortical Inhibition (SICI) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions
timeFrame: PRE (before intervention), POST (immediately after the intervention), POST 30 (30 minutes after the intervention), POST 60 (60 minutes after the intervention)
measure: Corticospinal Silent Period (CSP) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions
timeFrame: PRE (before intervention), POST (immediately after the intervention), POST 30 (30 minutes after the intervention), POST 60 (60 minutes after the intervention)
measure: Intracortical Facilitation (ICF) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions
timeFrame: PRE (before intervention), POST (immediately after the intervention), POST 30 (30 minutes after the intervention), POST 60 (60 minutes after the intervention)
measure: Lumbar Evoked Potentials (LEP) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions
timeFrame: PRE (before intervention), POST (immediately after the intervention), POST 30 (30 minutes after the intervention), POST 60 (60 minutes after the intervention)
measure: Maximal Compound Action Potentials (Mmax) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions
timeFrame: PRE (before intervention), POST (immediately after the intervention), POST 30 (30 minutes after the intervention), POST 60 (60 minutes after the intervention)
Secondary outcomes:
measure: Maximal Voluntary Isometric Contraction (MVIC) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions
timeFrame: PRE (before intervention), POST (immediately after the intervention), POST 30 (30 minutes after the intervention), POST 60 (60 minutes after the intervention)
measure: Sample Entropy (SampEn) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions
timeFrame: PRE (before intervention), POST (immediately after the intervention), POST 30 (30 minutes after the intervention), POST 60 (60 minutes after the intervention)
measure: Coefficient ov variation (CV) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions
timeFrame: PRE (before intervention), POST (immediately after the intervention), POST 30 (30 minutes after the intervention), POST 60 (60 minutes after the intervention)
Other outcomes:
Locations:
city: Almada
country: Portugal
facility: Egas Moniz School of Health & Science
state: Monte De Caparica
Study officials:
References: