Clinical trial NCT06524479: Investigating the Functional Characteristics of White Matter Fibers During Wakefulness and Sleep Based on SEEG
Official title: Investigating the Functional Characteristics of White Matter Fibers During Wakefulness and Sleep Based on SEEG
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Refractory Epilepsy
Sleep
Lead sponsor: Xuanwu Hospital, Beijing
Sponsor class: OTHER
First posted: 2024-07-29
Enrollment: 20
Sex: ALL
Minimum age (years): 14
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: This study aims to include electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who underwent SEEG electrode contacts traversing the brain's white matter. The collected data will be analyzed to investigate the functional characteristics of white matter fibers during wakefulness and sleep.

Detailed description: Sleep is a crucial function, and its disruption can have multiple effects on health. The daily alternation between sleep and wakefulness is one of the most dominant features of our lives and is a manifestation of the intrinsic 24 h rhythmicity underlying almost every aspect of our physiology.

The cerebral cortex makes up about 80% of the brain's volume and is responsible for many complex phereducednomena, including perception, thought, language, attention and memory. Sleep is considered a global state that influences the coordinated activity of the entire brain.

During sleep, studies have shown that the connectivity between neurons in the cerebral cortex weakens. White matter connects different brain regions, facilitating communication between various neural structures.Our scientific hypothesis is that white matter connectivity should also reduced.

Stereoelectroencephalography (SEEG) can directly record brain signals, providing a new method for tracking of connections between different brain areas, providing a new approach for understanding neuronal functional states and cortical excitability.studying the functional characteristics of white matter fibers during wakefulness and sleep.Based on SEEG and CCEP, this study aims to investigate the functional characteristics of white matter fibers during wakefulness and sleep.

Eligibility criteria: Inclusion Criteria:

* Drug-resistant focal epilepsy
* Justified SEEG exploration in the context of presurgical assessment of epilepsy
* Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings and analysis
* Written non-opposition to study participation

Exclusion Criteria:

* Pregnant women (Contraindication to SEEG exploration)
* Subjects that experience surgical complications during the implant procedure will be excluded from the study

Primary outcomes:
measure: SEEG recordings using cortico-cortical evoked potentials during daytime and sleeptime
timeFrame: Hospital discharge (maximum one month from SEEG implantation)
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Xuanwu Hospital, Beijing
state: Beijing
Study officials:
affiliation: Xuanwu Hospital, Beijing
name: Liankun Ren, MD
role: PRINCIPAL_INVESTIGATOR
References: