Clinical trial NCT04157868: Early rhBNP on Myocardial Work in Patients With STEMI
Official title: The Impact of Early rhBNP on Myocardial Work in Patients With Anterior ST-segment Elevation Myocardial Infarction After Percutaneous Coronary Intervention
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: ST-Segment Elevated Myocardial Infarction
Keywords: ST-Segment Elevated Myocardial Infarction
rhBNP
non-invasive myocardial work
Lead sponsor: RenJi Hospital
Sponsor class: OTHER
First posted: 2019-11-08
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study intends to evaluate the efficacy of early rhBNP on myocardial work in patients with anterior ST-segment elevation myocardial infarction after percutaneous coronary intervention


Eligibility criteria: Inclusion Criteria:

* 1. Anterior myocardial infarct (anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within 12 hours after onsets of symptom;

  2. No contraindication for rhBNP;

  3. Left anterior descending (LAD) as culprit vessel, with TIMI 0-1 grade.

Exclusion Criteria:

* 1.Cardiogenic shock (systolic BP \<90mmHg after fluid infusion or systolic BP\<100mmHg after vasoactive drugs);

  2. History of myocardial infarct;

  3.Severe arrhythmia: with III degree A-V block ,atrial fibrillation,ventricular fibrillation,ventricular tachycardia;

  4. Any history of severe renal or hepatic dysfunction (hepatic failure, cirrhosis, portal hypertension or active hepatitis); neutropenia or thrombocytopenia; known acute pancreatitis;

  5. Pregnant or lactating;

  6. life expectancy≤12 months;

  7. Inability to follow the protocol and comply with follow-up requirements or any other reason the investigator feels would place the patient at increased risk;

Primary outcomes:
measure: Global myocardial work efficiency by echocardiography
timeFrame: 30 days after PCI
Secondary outcomes:
measure: Global myocardial work index by echocardiography
timeFrame: Day 1, 7, 30 after PCI
measure: Global myocardial constructive work by echocardiography
timeFrame: Day 1, 7, 30 after PCI
measure: Global myocardial waste work by echocardiography
timeFrame: Day 1, 7, 30 after PCI
measure: Clinical Outcomes
timeFrame: 30 days after PCI
Other outcomes:
Locations:
Study officials:
affiliation: Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
name: Song Ding, MD,Ph.D.
role: PRINCIPAL_INVESTIGATOR
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