Clinical trial NCT06377943: The Interaction Between Resting Metabolic Rate, Physical Activity and Thyroid Hormone in Females
Official title: The Interaction Between Resting Metabolic Rate, Physical Activity and Thyroid Hormone in Females
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Thyroid
Physical Activities
Resting Energy Expenditure
Lead sponsor: Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Sponsor class: OTHER
First posted: 2024-04-22
Enrollment: 50
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study participants are adult healthy females.

Brief summary: This Study is focused on the interaction between resting metabolic rate (RMR), physical activity (PA), and thyroid hormones (TH). TH controls almost all the cell activities of the body so, it is known as one of the major regulatory hormones. This is the reason for individuals who suffer from thyroid disorders show abnormal metabolism. Recently it was suggested that interindividual variations in thyroid hormone levels also influence daily physical activity.

Detailed description: In this study, investigators will recruit adult females with a BMI ≥18.5. After the screening process, eligible volunteers will undergo certain measurements including body composition, resting metabolism daily physical activity, thyroid hormone levels, and total energy expenditure. The investigators will access the changes in resting metabolism and daily physical activities with the differences in thyroid hormone levels.

Eligibility criteria: Inclusion Criteria:

* Female age ≥18;
* BMI≥18.5

Exclusion Criteria:

* Intended weight change exceeding 2kg within the past three months;
* Having any special medical diets or having eating disorders;
* Pregnant women or breastfeeding women;
* People who have metal implants in their bodies;
* Patients with metabolic diseases, infectious diseases, and genetic disorders such as hypothyroidism, and hyperthyroidism;
* Patients with a personal or family history of medullary thyroid carcinoma (MTC), or patients with rare type 2 multiple endocrine tumor syndrome (MEN2); People with a fear of needles (Trypanophobia), claustrophobia; People who are fear of blood (Hemophobia) or pathological hypotension;

Primary outcomes:
measure: Body weight
timeFrame: Measurements will take at the first day of the visit
measure: Height
timeFrame: Measurements will take at the first day of the visit
measure: Waist and Hip circumferences
timeFrame: Measurements will take at the first day of the visit
measure: Fat mass
timeFrame: Measurements will take at the first day of the visit
measure: Far free mass
timeFrame: Measurements will take at the first day of the visit
measure: Bone mass
timeFrame: Measurements will take at the first day of the visit
measure: Resting Metabolism
timeFrame: Measurements will take at the first day of the visit.
measure: Physical activity
timeFrame: Measurements last for 14 days
measure: Thyroid hormone
timeFrame: Blood samples will collect at the first day of the visit.
Secondary outcomes:
measure: Total energy expenditure
timeFrame: Measurements take for 14 days
Other outcomes:
Locations:
Study officials:
affiliation: Shenzhen Institute of Advanced Technology, CAS
name: John R Speakman, PhD
role: STUDY_CHAIR
References: