Clinical trial NCT04996290: Combined PENG and LFCN Block for Total Hip Arthroplasty
Official title: Combined Pericapsular Nerve Group (PENG) and Lateral Femoral Cutaneous Nerve (LFCN) Block for Total Hip Arthroplasty: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anesthesia, Conduction
Pain, Postoperative
Arthroplasty, Replacement, Hip
Keywords: regional anesthesia
postoperative pain
total hip arthroplasty
pericapsular nerve group block
Lead sponsor: University Hospital, Antwerp
Sponsor class: OTHER
First posted: 2021-08-09
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: prospective randomized controlled trial
Primary purpose: TREATMENT

Brief summary: A clinical trial investigating the effect of a combined locoregional anesthesia technique on the postoperative analgesia outcomes after a total hip arthroplasty. A PENG block will be used in combination with a LFCN block. The results will be compared to a control group that is solely treated with intravenous analgesia. This technique aims to provide improved pain scores after surgery without interference of revalidation.


Eligibility criteria: Inclusion Criteria:

* adult patients who underwent a primary total hip replacement under general anesthesia

Exclusion Criteria:

* insulin dependent diabetes mellitus
* chronic pain
* severe dementia or mental retardation
* allergy to local anesthetics

Primary outcomes:
measure: Initial pain score
timeFrame: 0 hours postoperative
measure: Pain score after 2h
timeFrame: 2 hours postoperative
measure: Pain score after 24h
timeFrame: 24 hours postoperative
Secondary outcomes:
measure: Initial motor function
timeFrame: 0 hours postoperative
measure: Motor function after 2h
timeFrame: 2 hours postoperative
measure: Motor function after 24h
timeFrame: 24 hours postoperative
measure: Intraoperative opioids
timeFrame: intraoperative
measure: Postoperative opioids
timeFrame: 24 hours postoperative
Other outcomes:
Locations:
city: Deurne
country: Belgium
facility: AZ Monica
Study officials:
affiliation: AZ Monica
name: Yzabel Vandevivere, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Giron-Arango L, Peng PWH, Chin KJ, Brull R, Perlas A. Pericapsular Nerve Group (PENG) Block for Hip Fracture. Reg Anesth Pain Med. 2018 Nov;43(8):859-863. doi: 10.1097/AAP.0000000000000847.
citation: Morrison C, Brown B, Lin DY, Jaarsma R, Kroon H. Analgesia and anesthesia using the pericapsular nerve group block in hip surgery and hip fracture: a scoping review. Reg Anesth Pain Med. 2021 Feb;46(2):169-175. doi: 10.1136/rapm-2020-101826. Epub 2020 Oct 27.
citation: Wainwright TW, Gill M, McDonald DA, Middleton RG, Reed M, Sahota O, Yates P, Ljungqvist O. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS(R)) Society recommendations. Acta Orthop. 2020 Feb;91(1):3-19. doi: 10.1080/17453674.2019.1683790. Epub 2019 Oct 30.
citation: Roy R, Agarwal G, Pradhan C, Kuanar D. Total postoperative analgesia for hip surgeries, PENG block with LFCN block. Reg Anesth Pain Med. 2019 Mar 28:rapm-2019-100454. doi: 10.1136/rapm-2019-100454. Online ahead of print. No abstract available.
citation: Hojer Karlsen AP, Geisler A, Petersen PL, Mathiesen O, Dahl JB. Postoperative pain treatment after total hip arthroplasty: a systematic review. Pain. 2015 Jan;156(1):8-30. doi: 10.1016/j.pain.0000000000000003.