Clinical trial NCT05688150: Prevalence and Associated Factors of Sarcopenia Among Elderly Patients in Osteoporosis Clinic
Official title: Prevalence and Associated Factors of Sarcopenia Among Elderly Patients in Osteoporosis Clinic
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sarcopenia
Osteoporosis
Keywords: osteosarcopenia
sarcopenia
osteoporosis
geriatric medicine
Lead sponsor: Kowloon Hospital, Hong Kong
Sponsor class: OTHER
First posted: 2023-01-18
Enrollment: 94
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who attended the osteoporosis clinic of Kowloon Hospital from June to December 2022.

Brief summary: This was a cross-sectional study. Patients who attended the osteoporosis clinic of Kowloon Hospital from June to December 2022 were recruited.

Grip strength and appendicular skeletal muscle mass index were measured with a Jamar dynamometer and a bioimpedance analyser. Since most patients in our clinic are of Chinese ethnicity, the diagnostic criteria in the Consensus Update on Sarcopenia Diagnosis and Treatment by the Asian Working Group for Sarcopenia in 2019 was utilised. The diagnosis of sarcopenia was established by the presence of both low grip strength (Male: \< 28 kg, Female \< 18 kg) and low appendicular skeletal mass (Male: \< 7.0 kg/m2, Female: \< 5.7 kg/m2)


Eligibility criteria: Inclusion Criteria:

* Patients aged 60 years old or above
* Diagnosed with osteoporosis by: Fragility fracture or T-score ≤-2.5 SDs at any site on DXA scan and;
* Able to read and write Chinese

Exclusion Criteria:

* Unable to maintain standing posture for bioimpedance analysis
* Modified Functional Ambulation Classification (MFAC) ≤ IV
* Incompetent in giving consent
* Unable to follow instructions
* Implanted with metal in any of four limbs
* Implanted with pacemaker, implantable cardioverter defibrillator or any other types of electrical device

Primary outcomes:
measure: Prevalence of Sarcopenia
timeFrame: June - December 2022
measure: Grip strength
timeFrame: June - December 2022
measure: Appendicular Skeletal Muscle Mass Index
timeFrame: June - December 2022
Secondary outcomes:
measure: Association between BMI and Sarcopenia.
timeFrame: June - December 2022
measure: Association between Frailty and Sarcopenia.
timeFrame: June - December 2022
measure: Association between Charlson Comorbidities Index and Sarcopenia
timeFrame: June - December 2022
measure: Association between Bone Mineral Densities and Sarcopenia
timeFrame: June - December 2022
Other outcomes:
Locations:
city: Kowloon
country: Hong Kong
facility: Kowloon Hospital
Study officials:
References:
citation: Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc. 2020 Mar;21(3):300-307.e2. doi: 10.1016/j.jamda.2019.12.012. Epub 2020 Feb 4.