Clinical trial NCT00326664: AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors
Official title: A Phase I Clinical Trial of AZD2171 in Children With Recurrent or Progressive Central Nervous System (CNS) Tumors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Childhood Atypical Teratoid/Rhabdoid Tumor
Childhood Central Nervous System Germ Cell Tumor
Childhood Cerebral Anaplastic Astrocytoma
Childhood Cerebral Astrocytoma
Childhood Grade I Meningioma
Childhood Grade II Meningioma
Childhood Grade III Meningioma
Childhood Infratentorial Ependymoma
Childhood Oligodendroglioma
Childhood Spinal Cord Neoplasm
Childhood Supratentorial Ependymoma
Recurrent Childhood Brain Neoplasm
Recurrent Childhood Brain Stem Glioma
Recurrent Childhood Cerebellar Astrocytoma
Recurrent Childhood Cerebral Astrocytoma
Recurrent Childhood Ependymoma
Recurrent Childhood Medulloblastoma
Recurrent Childhood Pineoblastoma
Recurrent Childhood Subependymal Giant Cell Astrocytoma
Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor
Recurrent Childhood Visual Pathway Glioma
Lead sponsor: National Cancer Institute (NCI)
Sponsor class: NIH
First posted: 2006-05-17
Enrollment: 55
Sex: ALL
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This phase I trial is studying the side effects and best dose of AZD2171 in treating young patients with recurrent, progressive, or refractory primary CNS tumors. AZD2171 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

Detailed description: PRIMARY OBJECTIVES:

I. Determine the maximum tolerated dose of AZD2171 in pediatric patients with recurrent, progressive, or refractory primary CNS tumors.

II. Describe the toxicity profile and dose-limiting toxicities of AZD2171 in these patients.

SECONDARY OBJECTIVES:

I. Characterize inter-patient variability in the pharmacokinetics of AZD2171 in these patients.

II. Describe changes in circulating endothelial cells (CECs) and circulating endothelial cell precursors (CEPs) in patients treated with AZD2171 at different dose levels.

III. Correlate changes in CECs, CEPs, plasma, serum, and urine levels of proteins with angiogenesis, including vascular endothelial growth factor (VEGF) and VEGF receptor, in patients treated with AZD2171 at different dose levels.

IV. Correlate changes in CECs, CEPs, and angiogenic modulators with changes in magnetic resonance (MR) perfusion.

V. Obtain preliminary evidence of biologic activity of AZD2171 by evaluating alterations in tissue perfusion, tumor blood flow, and metabolic activity using MR perfusion and diffusion imaging, and positron-emission tomography, and correlating these findings with changes in tumor size by standard MRI.

OUTLINE: This is a dose-escalation, multicenter study. Patients are stratified according to concurrent enzyme-inducing anticonvulsant drugs (yes vs no).

Patients receive oral AZD2171 once daily on days 1-28. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.

For each stratum, cohorts of 2-6 patients receive escalating doses of AZD2171 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which 25% of patients experience dose-limiting toxicity. Once the MTD is determined, an additional 6 patients per stratum are enrolled and treated at the MTD.

After completion of study, patients are followed at 30 days.

Eligibility criteria: Inclusion Criteria:

* Histologically confirmed primary CNS tumor

  * Histologically benign brain tumors (e.g., low-grade glioma) allowed
  * Histological requirement waived for intrinsic brain stem or diffuse optic pathway tumors, but must have clinical and/or radiographic evidence of progression
* Recurrent, progressive, or refractory disease
* Absolute neutrophil count \>= 1,000/mm\^3 (unsupported)
* Platelet count \>= 75,000/mm\^3 (unsupported)
* Creatinine =\< 1.5 times upper limit of normal (ULN) OR glomerular filtration rate \>= 70 mL/min
* Bilirubin =\< 1.5 times ULN
* ALT =\< 2.5 times ULN
* Urine dipstick or urinalysis \< 1+ protein
* Albumin \>= 3 g/dL
* Karnofsky performance status (PS) 60-100% (\> 16 years of age) OR Lansky PS 60-100% (=\< 16 years of age)
* Karnofsky/Lansky PS 70-100% for patients at increased risk for compromised LVEF
* Hemoglobin \>= 8 g/dL (transfusion support allowed)
* No overt renal, hepatic, cardiac, or pulmonary disease
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* QTc prolongation =\< 500 msec
* No other significant ECG abnormality within the past 14 days
* No clinically significant, unrelated, systemic illness, including serious infections or significant cardiac, pulmonary, hepatic, or other organ dysfunction, that would preclude study participation
* No uncontrolled hypertension

  * Defined as systolic and diastolic BP \> 95th percentile for age (ages 1-17)
  * Defined as BP \> 140/90 (ages 18 and older)
* No New York Heart Association class III or IV disease and Karnofsky/Lansky PS \< 70

  * Class II disease controlled with treatment and increased monitoring is allowed
* Recovered from all prior therapy
* No prior AZD2171
* At least 3 weeks since prior myelosuppressive anticancer chemotherapy (6 weeks for nitrosoureas)
* More than 1 weeks since prior investigational or biologic agents

  * If the investigational or biologic agent has a prolonged half-life (\> 48 hours), then these patients must be discussed with the study chair prior to registration
* No concurrent drugs or biologics with proarrhythmic potential
* More than 3 months since last fraction of craniospinal radiotherapy or total-body irradiation
* More than 4 weeks since last fraction of focal irradiation to symptomatic metastatic sites
* At least 6 months since prior allogeneic bone marrow transplantation
* At least 3 months since prior autologous bone marrow or stem cell transplantation
* At least 1 week since prior filgrastim (G-CSF), sargramostim (GM-CSF), or epoetin alfa (2 weeks for pegfilgrastim)
* No other concurrent investigational agents
* Concurrent dexamethasone allowed provided patient is on a stable or decreasing dose for ≥ 1 week before study entry
* No concurrent chemotherapy
* No concurrent routine use of G-CSF, GM-CSF, or epoetin alfa
* Able to swallow tablets
* Any neurologic deficits must be stable for \>= 1 week
* If the investigational or biologic agent has a prolonged half-life (\> 48 hours), then these patients must be discussed with the study chair prior to registration

Exclusion Criteria:

* No known curative therapy available

Primary outcomes:
measure: Maximum tolerated dose, defined as the dose at which the model estimates that 25% of patients will experience dose-limiting toxicity as measured by NCI CTCAE v4.0
timeFrame: 42 days
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: UCSF Medical Center-Mount Zion
state: California
city: Washington
country: United States
facility: Children's National Medical Center
state: District of Columbia
city: Chicago
country: United States
facility: Lurie Children's Hospital-Chicago
state: Illinois
city: Boston
country: United States
facility: Dana-Farber/Harvard Cancer Center
state: Massachusetts
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
city: Philadelphia
country: United States
facility: Children's Hospital of Philadelphia
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Children's Hospital of Pittsburgh of UPMC
state: Pennsylvania
city: Memphis
country: United States
facility: Pediatric Brain Tumor Consortium
state: Tennessee
city: Memphis
country: United States
facility: St. Jude Children's Research Hospital
state: Tennessee
city: Houston
country: United States
facility: Texas Children's Hospital
state: Texas
city: Seattle
country: United States
facility: Seattle Children's Hospital
state: Washington
Study officials:
affiliation: Pediatric Brain Tumor Consortium
name: Mark Kieran
role: PRINCIPAL_INVESTIGATOR
References: