Clinical trial NCT02589990: Strength Training Adaptations, Age and Genes
Official title: Effect of Maximal Strength Training in Relation to Age and Genes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: health
muscle strength
exercise genomics
Lead sponsor: University of South-Eastern Norway
Sponsor class: OTHER
Collaborators: name: Norwegian University of Science and Technology
First posted: 2015-10-28
Enrollment: 76
Sex: ALL
Minimum age (years): 20
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: The study investigates the effect of maximal strength training on muscular strength and power in different age groups from 20 to 80 year old. It also relates the training adaptations to different known genes such as angiotensin I-converting enzyme (ACE) and Alpha-actinin-3 (ACTN3). Participants will complete an eight weeks, three times per week training intervention of maximal strength training with a pre-post design. In addition, blood samples will be collected for the analyses of genetic variances.

Detailed description: Aim: The study aims to investigate the effect of age and genes on training adaptations to a maximal strength training intervention.

Methods: Participants will be recruited through invitations at work places and other community arenas. The investigators aim to recruit 10-15 subjects in each of the following age groups: 20-29, 30-39, 40-49, 50-59, 60-69 and 70-80 years of age. Both genders will be included. All age groups will be matched for age-related baseline maximal strength and distribution between the two genders. All participants will be checked via a health registration scheme, and excluded if contra indications for hard physical training or testing should appear. When in doubt, the projects physician will decide on inclusion or exclusion due to a thorough examination. Subjects will give a blood sample to be analyzed for known genes such as ACE and ACTN3. The intervention has a pre- post design. Tests of maximal strength and power will be conducted in a leg-press machine, using the protocol assessing one repetition maximum (1RM) previously described. Force and Power will be measured by the Muscle Lab system from Ergotest Tech. (Langesund, Norway). The intervention is an eight week, three times per week protocol, each training session consisting of a standardized warm-up, and 4 repetitions x 4 sets with an intensity of 4 repetition maximum (4RM) performed in the leg press machine.There will be a three minutes pause between sets. Participants will be given instructions and supervision.

Hypothesis: Maximal strength training adaptations will be affected by age and baseline maximal strength but not by gender or genetic variations.

Eligibility criteria: Inclusion Criteria:

* Healthy adults 20 to 90 years old

Exclusion Criteria:

* Contraindications to maximum strength training and testing

Primary outcomes:
measure: Maximal muscle strength measured by 1 RM leg press in leg press machine
timeFrame: 8 weeks
Secondary outcomes:
measure: Blood sample will be collected to assess gene types Alpha Actinin 3, Angiotensin Converting Enzyme, Angiotensinogen
timeFrame: 8 weeks
measure: rate of force development in leg press measured by MuscleLab (Ergotest Tech., Langesund Norway)
timeFrame: 8 weeks
measure: agility will be measured by counter movement jump using the MuscleLab system by Ergotest Tech. (Langesund, Norway)
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Bø
country: Norway
facility: Telemark University College
state: Telemark
city: Trondheim
country: Norway
facility: Norwegian University of Science and Technology
Study officials:
affiliation: University of South-Eastern Norway
name: Øyvind Støren, PhD
role: STUDY_CHAIR
affiliation: University of South-Eastern Norway
name: Mona Sæbø, PhD
role: STUDY_DIRECTOR
References:
citation: Storen O, Helgerud J, Stoa EM, Hoff J. Maximal strength training improves running economy in distance runners. Med Sci Sports Exerc. 2008 Jun;40(6):1087-92. doi: 10.1249/MSS.0b013e318168da2f.
citation: Sunde A, Storen O, Bjerkaas M, Larsen MH, Hoff J, Helgerud J. Maximal strength training improves cycling economy in competitive cyclists. J Strength Cond Res. 2010 Aug;24(8):2157-65. doi: 10.1519/JSC.0b013e3181aeb16a.