Clinical trial NCT04554069: Effect of Different Antihypertensive Treatment on Serum Uric Acid in Newly Diagnosed Hypertensive Patients
Official title: Effect of Different Antihypertensive Treatment on Serum Uric Acid in Newly Diagnosed Hypertensive Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hypertension
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-09-18
Enrollment: 280
Sex: ALL
Minimum age (years): 30
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male and Female participants aged 30 years old and above will be invited to participate in this study.

Brief summary: Assessment of the influence of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension patients.

Detailed description: Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately.

Thiazide-type diuretics, angiotensin-converting enzyme (ACE) inhibitors and some of angiotensin-II receptor blockers (ARB) were reported to reduce renal excretion of urate and increased serum uric acid levels, Beta-blockers also elevate serum uric acid levels.

Hyperuricemia is a risk factor for cardiovascular diseases. Hyperuricemia was found to correlate with hypertension excluding the influence of other factors such as age and renal function. Furthermore, many studies found that hyperuricemia was independently associated with cardiovascular events in patients treated with antihypertensive drugs.

It is important to control serum uric acid levels in hypertensive patients treated with antihypertensive drugs in order to reduce the risk of gout and cardiovascular events. There is a gap in knowledge in studies showing the effect of antihypertensive drugs on serum uric acid in newly diagnosed hypertensive patients.

Eligibility criteria: Inclusion Criteria:

* All newly diagnosed hypertensive patients aged 30 years old and above will be invited to participate in this study

Exclusion Criteria:

1. Patients below 30 years old.
2. Patients with kidney disease.
3. Patients who are taking medications known to increase SUA as (Thiazide and Loop diuretics, Salicylates, Cyclosporin use) or decrease the level of uric acid in the urine as (Allopurinol, Febuoxstate).

Primary outcomes:
measure: The effect of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension.
timeFrame: 6 months from baseline
Secondary outcomes:
measure: obesity
timeFrame: 6 months from baseline
Other outcomes:
Locations:
Study officials:
affiliation: faculty of medicine
name: Dalia Mahran, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Verdecchia P, Schillaci G, Reboldi G, Santeusanio F, Porcellati C, Brunetti P. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. Hypertension. 2000 Dec;36(6):1072-8. doi: 10.1161/01.hyp.36.6.1072.
citation: Shankar A, Klein R, Klein BE, Nieto FJ. The association between serum uric acid level and long-term incidence of hypertension: Population-based cohort study. J Hum Hypertens. 2006 Dec;20(12):937-45. doi: 10.1038/sj.jhh.1002095. Epub 2006 Oct 5.