Clinical trial NCT06007755: Exploring of Serum Biomarkers of Delirium After Cardiovascular Surgery
Official title: Exploring of Serum Biomarkers of Delirium After Cardiovascular Surgery
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Delirium
Keywords: delirium
biomarker
cardiovascular surgery
H3K18la
exosome
phospho-tau
Aβ
Lead sponsor: Huazhong University of Science and Technology
Sponsor class: OTHER
First posted: 2023-08-23
Enrollment: 113
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients aged over 18 years undergoing cardiovascular surgery

Brief summary: The incidence of postoperative delirium in patients after cardiovascular surgery is very high, which seriously affects the short-term and long-term prognosis of patients, but its mechanism is not clear. Recent studies have found that lactic acid participates in the process of sepsis by inducing histone lactatation in macrophages. histone H3 lysine 18 lactylation (H3K18la) is significantly associated with the severity of disease and inflammatory response. Inflammation plays an important role in postoperative delirium. We therefore hypothesized that macrophage H3K18la also plays a role in postoperative delirium. At the same time, the latest literature shows that the early markers of Alzheimer's disease (AD), such as Aβ, exosomes and phosphorylated tau, etc. \[5\], can also be detected in the serum of AD patients. Given the obvious correlation between Alzheimer's disease and postoperative delirium \[6\], we hypothesized that serum biomarkers of AD could also be used as serum biomarkers for postoperative delirium.

The objectives of this study were to investigate the correlation between H3K18 in serum monocytes and postoperative delirium and its severity in patients undergoing cardiovascular surgery. Meanwhile, we also detect the serum levels of biomarkers of AD, such as Aβ, tau and exosomes etc., in patients undergoing major cardiac surgery. We aim to find the serum biomarkers of delirium after major cardiac surgery, so as to provide a more convenient diagnostic basis for the prevention of postoperative delirium.


Eligibility criteria: Inclusion Criteria:

patients who receive cardiovascular surgery

* Patients participated voluntarily and signed informed consent

Exclusion Criteria:

* past medical history of neurological and psychiatric diseases; severe visual or hearing impairment;

Primary outcomes:
measure: Incidence of postoperative delirium
timeFrame: After surgery through to postoperative day 7
Secondary outcomes:
measure: the level of H3K18 in serum monocytes of postoperative delirium and un-delirium patients
timeFrame: Perioperative data
measure: the level of Aβ in serum of postoperative delirium and un-delirium patients
timeFrame: Perioperative data
measure: the level of tau in serum of postoperative delirium and un-delirium patients
timeFrame: Perioperative data
measure: the level of exosomes in serum of postoperative delirium and un-delirium patients
timeFrame: Perioperative data
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
state: Hubei
Study officials:
References: