Clinical trial NCT03917355: Nonverbal Synchrony, Therapeutic Alliance and Treatment Engagement in First Episode Schizophrenia
Official title: Study of the Link Between Patient/Psychiatrist Motor Synchronization and Treatment Adhesion in Patients With First Psychotic Episode, ASMASS Project
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Schizophrenics
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2019-04-17
Enrollment: 7
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with a first psychotic episode

Brief summary: The quality of the therapeutic intervention in a first psychotic episode is a major challenge for quality and effectiveness of treatment. This project aims to better understand the mechanisms underlying the quality of communication between patient and psychiatrist, especially those related to non-verbal communication. Psychiatrist/patient interpersonal motor synchronization is a reliable index of therapeutic alliance and a predictor of psychotherapy effectiveness. This project aims to show a link between psychiatrist and patient motor synchrony and treatment adherence. This link could be explained by an association between therapeutic alliance and motor synchronization.

Detailed description: Several studies have highlighted the utmost importance of initial medical and psychosocial support during a first psychotic episode. Recent research has shown that non-verbal communication and particularly interpersonal motor synchronization between the patient and his psychiatrist is a key factor in therapeutic alliance. However, such hypothesis have never been tested in terms of treatment adherence neither in a first psychotic episode, nor during a 6-month follow-up. By measuring the interpersonal motor synchronization between the patient and psychiatrist during a video recorded interview at inclusion, month-3 and month-6, the project aims to validate the hypothesis that a high level of interpersonal synchronization should be associated with a high level of therapeutic alliance. This therapeutic alliance being hypothesized as a mediator between synchronization and treatment adherence, the project should show for the first time in a first psychotic episode that the use of reliable and objective variables extracted from the analysis of the synchronization between psychiatrist and patient allows to predict the outcome of therapeutic and treatment alliance.

Eligibility criteria: Inclusion Criteria:

* Patients after hospitalisation for a first psychotic episode (OMS criteria 1992)
* Patients fluent in French (spoken and written)
* Age ≥ 18 years and \< 50 years
* signed informed consent
* participation noted in medical files.

Exclusion Criteria:

* Inpatients
* History of brain trauma
* History of neurological disease
* Current Electro-convulsive-treatment
* Drug abuse and dependence (except for tabacco and cannabis)
* Pregnant/breast feeding woman

Primary outcomes:
measure: Scale of therapeutic compliance
timeFrame: Baseline
measure: Scale of therapeutic compliance
timeFrame: 3 months
measure: Scale of therapeutic compliance
timeFrame: 6 months
Secondary outcomes:
measure: Therapeutic alliance
timeFrame: Baseline
measure: Therapeutic alliance
timeFrame: 3 months
measure: Therapeutic alliance
timeFrame: 6 months
measure: Positive and Negative Symptom Scale
timeFrame: Baseline
measure: Positive and Negative Symptom Scale
timeFrame: 3 months
measure: Positive and Negative Symptom Scale
timeFrame: 6 months
measure: Clinical Assessment Interview for Negative Symptoms
timeFrame: Baseline
measure: Clinical Assessment Interview for Negative Symptoms
timeFrame: 3 months
measure: Clinical Assessment Interview for Negative Symptoms
timeFrame: 6 months
measure: Functioning Remission of General Schizophrenia
timeFrame: Baseline
measure: Functioning Remission of General Schizophrenia
timeFrame: 3 months
measure: Functioning Remission of General Schizophrenia
timeFrame: 6 months
measure: French National Adult Reading Test
timeFrame: Baseline
measure: French National Adult Reading Test
timeFrame: 3 months
measure: French National Adult Reading Test
timeFrame: 6 months
measure: California Verbal Learning Test
timeFrame: Baseline
measure: California Verbal Learning Test
timeFrame: 3 months
measure: California Verbal Learning Test
timeFrame: 6 months
measure: Trail Making Test
timeFrame: Baseline
measure: Trail Making Test
timeFrame: 3 months
measure: Trail Making Test
timeFrame: 6 months
measure: Energy Motion Analysis
timeFrame: Baseline
measure: Energy Motion Analysis
timeFrame: 3 months
measure: Energy Motion Analysis
timeFrame: 6 months
Other outcomes:
Locations:
city: Montpellier
country: France
facility: CHU Montpellier
Study officials:
References: