Clinical trial NCT05408403: Comparison of the Effects of TFPB and Anterior QLB on Postoperative Analgesia in Cesarean Section Surgery
Official title: Comparison of the Effects of Transversalis Fascia Plane Block and Anterior QLB ( TFPB and Anterior QLB ) on Postoperative Analgesia in Cesarean Section Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Analgesia
Acute Pain
Chronic Pain
Keywords: Regional Anesthesia
Acute and chronical pain
Transversalis Fascia Plane Block
Quadratus Lumborum Blocks
Cesarean Section
Lead sponsor: Ondokuz Mayıs University
Sponsor class: OTHER
First posted: 2022-06-07
Enrollment: 49
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomization of the study will be done by a doctor who will not participate in patient follow-up with closed envelopes using computer-generated randomization codes.
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study evaluates the postoperative analgesic effects of transversalis fascia plane block and anterior quadratus lumborum block in patients having cesarean section under general anesthesia. General anesthesia will be performed to all patients for the surgery.

Detailed description: In this study, patients are divided into two groups. After the general anesthesia is performed and cesarean section surgery is over; TFPB block will be performed to patients in Group A ; while anterior QLB block will be performed to patients in Group B. In addition, patient controlled analgesia (PCA) will be used in the first 24 hours postoperatively. Group A - Patients in group A will have TFPB block after the surgery. In addition, patient controlled analgesia (PCA) will be used in the first 24 hours postoperatively. Group B - Patients in group B will have anterior QLB block after the surgery. In addition, patient controlled analgesia (PCA) will be used in the first 24 hours postoperatively.

Eligibility criteria: Inclusion Criteria:

* Being pregnant for at least 37 weeks
* Planning an elective cesarean operation
* Being between the ages of 18-45

Exclusion Criteria:

* American Society of Anesthesiologists (ASA) 3-4 patients with comorbidities (Serious renal, cardiac, hepatic disease)
* Being operated with spinal anesthesia
* Obesity (\> 100 kg, BMI\> 35 kg / m2)
* Contraindication of regional anesthesia (coagulopathy, abnormal international normalized ratio (INR), thrombocytopenia, infection at the injection site)
* Hypersensitivity to local anesthetics or a history of allergy
* Patients with a history of opioid use longer than four weeks
* Patients with psychiatric disorders
* Patients with anatomic deformity
* Patients who do not want to participate

Primary outcomes:
measure: Opioid consumption in the first 24 hours after surgery
timeFrame: Postoperative Day 1
Secondary outcomes:
measure: Post-operative acute pain
timeFrame: Postoperative Day 1
measure: The time of first opioid requirement
timeFrame: Postoperative Day 1
Other outcomes:
measure: The incidences of post-operative nausea and vomiting (PONV)
timeFrame: Postoperative Day 1
measure: The incidence of side effects related to local anesthetics, opioid use and regional anesthesia technic
timeFrame: Postoperative Day 1
Locations:
city: Samsun
country: Turkey
facility: Ondokuz Mayıs University Faculty of Medicine
Study officials:
affiliation: Ondokuz Mayıs University
name: Sezgin Bilgin
role: PRINCIPAL_INVESTIGATOR
References: