louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06219603: Knowledge and Awareness About Inflammatory Articular Diseases
Official title: Knowledge and Awareness About Inflammatory Articular Diseases: A Cross Sectional Survey From a Syrian Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Inflammatory Articular Diseases
Keywords: knowledge
Awareness
Inflammatory Articular Diseases
Syrian population
Lead sponsor: Syrian Private University
Sponsor class: OTHER
First posted: 2024-01-23
Enrollment: 641
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A random sample from all segments of the Syrian population

Brief summary: The manuscript describes the level of knowledge and awareness about Inflammatory Articular Diseases in a Syrian population. we found that awareness of Inflammatory Articular Diseases is mostly bad and very bad in our sample. Also, we showed how the level of awareness changes due to the change of many factors such as (sex, age, residency, education, marital status, and others ).

Our community-based survey was the first conducted in Syria. we have included a total of 641 participants who were directed to the first part of the survey to complete questions around socio-demographic data and awareness questions about Inflammatory Articular Diseases. We ranked our participants into five levels: excellent, good, average, bad, and very bad.

Finally, we compared our results with other 4 original published studies, and we found many Boolean points of similarity and many other inspiring points of difference.


Eligibility criteria: Inclusion Criteria:

* all participants older than 18 years and younger than 70

Exclusion Criteria:

* Non-Syrians

Primary outcomes:
measure: knowledge about Inflammatory Articular Diseases
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Damascus
country: Syrian Arab Republic
facility: Faculty of Medicine, syrian private University, Syria
Study officials:
References:
Clinical trial NCT02599103: The Effects of Various Cooking Oils on Health Related Biomarkers in Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colorectal Neoplasms
Lead sponsor: Academia Sinica, Taiwan
Sponsor class: OTHER
First posted: 2015-11-06
Enrollment: 17
Sex: MALE
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: Fats and oils play important roles in maintaining human nutrition and health through providing energy, essential fatty acids, and acting as modulators of many biological processes (signal transduction, immunity and inflammation). Due to differences in the fatty acid composition and content of antioxidants of individual cooking oils, the degree of oxidative and thermolytic reactions may vary oil by oil. It is lack of human feeding study to investigate the molecular mechanisms on how and which deep-fried oil exerts its adverse effects. The investigators are also lack of biomarkers for monitoring deep-fried oil exposure. Therefore, the purpose of this study is to compare how human body responds differently to several popular uncooked and deep-fried oils with varied fatty acid compositions with respect of oxylipin profile, inflammatory markers, non-targeted metabolomics, and transcriptomics. The investigators will recruit 20 volunteers, provided them once a week the milk shakes prepared from 60g of olive oil, soybean oil, palm oil, camellia oil, tallow (butter), and deep-fried oils of the last 4, respectively; in comparison with a no-fat milk shake control. The experiments lasted for 10 weeks.。Each time; serum, plasma, whole blood and urine samples were collected at baseline, after 2 hours, and after 4 hours. The investigators anticipate to find biomarker(s) for deep-frying, and contribute to the understanding of molecular mechanisms on how deep-fried oils exert adverse effects toward health through integrative omics or so-called system biology approaches.


Eligibility criteria: Inclusion Criteria:

* Non-smoking, non-drinker, usual dietary intake
* BMI : 18.5\~27 kg/m2

Exclusion Criteria:

1. Over the past two weeks have suffered from acute illness.
2. None of the subjects was taking any supplemental vitamins, antioxidants or medication at that time.
3. Taking steroids or non-steroidal anti-inflammatory drug, such as Aspirin or Panadol in the past one week.
4. Cancer or other severe diseases was diagnosed.

Primary outcomes:
measure: The changs of metabolomics profile between before and after oil consumption
timeFrame: baseline to 2 hours and 4 hours after oil consumption
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Institute of Biomedical Sciences, Academia Sinica
name: Wen-Harn Pan, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04183803: Robotic Assistance for Tunnel Positioning in Anterior Cruciate Ligament Reconstruction
Official title: Robotic Assistance for Tunnel Positioning in Anterior Cruciate Ligament Reconstruction
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Anterior Cruciate Ligament Injuries
Keywords: anterior cruciate ligament
reconstruction
robot
tunnel
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2019-12-03
Enrollment: 30
Sex: ALL
Minimum age (years): 10
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Accurate ideal graft tunnel positioning is essential for the successful application of anatomic anterior cruciate ligament (ACL) reconstruction. The accurate insertion of the tibial tunnel (TT) and femoral tunnel (FT) remain a challenge.

A robotic assisted new strategy for drill TT and FT in ACL reconstruction will be performed and its efficacy and accuracy will be assess.

The investigators will prospectively include 30 patients with ACL rupture requiring surgical treatment. The reconstruction will be performed with hamstring tendon graft or patellar tendon graft. The femoral and tibial tunnels placement will be guided by the Rosa robot (Zimmer®).


Eligibility criteria: Inclusion Criteria:

* All patients treated at CHU Amiens-Picardie for ACL reconstruction by practitioner who has robot experience.
* children and adults from 10 to 45 years old

Exclusion Criteria:

* Patients managed by another ACL reconstruction technique
* Patients under guardianship, curators deprived of liberty
* Pregnant and nursing women.
* Patient who refused to participate in the study and to sign informed consent

Primary outcomes:
measure: Accuracy of tunnel positioning
timeFrame: Day 0; during the operation
Secondary outcomes:
measure: Range of motion of the knee
timeFrame: day 0, during operation
measure: Range of motion of the knee
timeFrame: up to 2 years; during follow-up
measure: Range of motion of the knee
timeFrame: up to 2 years; during follow-up
measure: Range of motion of the knee
timeFrame: day 0, during operation
measure: Range of motion of the knee
timeFrame: up to 2 years; during follow-up
measure: Range of motion of the knee
timeFrame: day 0, during operation
measure: Knee stability
timeFrame: day 0; during operation
measure: Knee stability
timeFrame: day 0; during operation
measure: Knee stability
timeFrame: up to 2 years; during follow-up
measure: Knee stability
timeFrame: up to 2 years; during follow-up
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens
Study officials:
affiliation: CHU Amiens
name: François Deroussen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06295003: Impact of COVID-19 Pandemic on Headache Evaluations in the Pediatric Emergency Department
Official title: Impact of COVID-19 Pandemic on Headache Evaluations in the Pediatric Emergency Department
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19
Headache Disorders
Emergency Service, Hospital
Lead sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Sponsor class: OTHER
First posted: 2024-03-06
Enrollment: 700
Sex: ALL
Minimum age (years): 2
Maximum age (years): 18
Standard ages: CHILD
ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients aged 2-18 years evaluated in Pediatric Emergency Department because of headache as main symptom

Brief summary: Background: To evaluate the impact of COVID-19 on evaluations in the pediatric emergency department (ED) because of headache as main symptom.

Methods: Number and clinical features of patients evaluated in the pediatric ED of a single site in Milan,Italy, were collected between January 2017 and January 2022. The impact of COVID-19 on evaluation rates was quantified by using the incidence rate ratio (IRR) and 95% confidence intervals (CI) between the pandemic (March 2020 to January 2022) and the prepandemic period (January 2017 to February 2020).


Eligibility criteria: Inclusion Criteria:

* range of age: 2 - 18 years
* sex: all
* headache as main symptom

Exclusion Criteria:

* headache in the context of head trauma, because of different diagnostic-care in Pediatric Emergency Department

Primary outcomes:
measure: During the study period, 890 evaluations were registered: the number of partecipants was 689 over the prepandemic period and 201 over the pandemic period. Mean age at evaluation was 10 years (range: 1 to 17 years).
timeFrame: the pandemic (March 2020 to January 2022) and the prepandemic period (January 2017 to February 2020).
Secondary outcomes:
measure: Evaluation rates per month were 18.1 during the prepandemic period and 8.7 during COVID-19 pandemic, with peaks in autumn and winter and drops in summer. The reduction in evaluation rate was higher for secondary headache when compared with primary one
timeFrame: the pandemic (March 2020 to January 2022) and the prepandemic period (January 2017 to February 2020).
Other outcomes:
Locations:
city: Milan
country: Italy
facility: Pediatric Emergency Department Clinica de Marchi, Foundation IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Study officials:
References:
Clinical trial NCT01967303: Restless Legs Syndrome in Stroke Patients
Official title: Restless Legs Syndrome in Stroke Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Restless Legs Syndrome
Stroke
Transient Ischemic Attack
Keywords: Restless legs syndrome
Stroke
Transient ischemic attack
Cerebrovascular risk factors
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2013-10-22
Enrollment: 447
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients hospitalized with stroke or transient ischemic attack.

Brief summary: Our study aimed to examine a possible association between Restless legs syndrome and cerebrovascular disease, by examining patients during hospitalization for acute stroke or transient ischemic attack, in a matched case-control design.


Eligibility criteria: Inclusion Criteria:

* 18 years old or older
* Hospitalization for stroke or transient ischemic attack

Exclusion Criteria:

* 18 years old or younger
* No stroke or transient ischemic attack

Primary outcomes:
measure: Prevalence of Restless legs syndrome in patients with stroke or Transient ischemic attack vs. prevalence in controls.
timeFrame: At time of interview
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Rambam Health Care Campus, Haifa, Israel
name: Ilana Schlesinger
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02049203: Safety of Ataciguat in Patients With Moderate Calcific Aortic Valve Stenosis
Official title: A Phase Ib Randomized, Placebo-controlled, Double-blinded Study Evaluating the Safety of Ataciguat (HMR1766) in Patients With Moderate Calcific Aortic Valve Stenosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Aortic Valve Stenosis
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
Collaborators: name: National Center for Advancing Translational Sciences (NCATS)
name: Sanofi-Synthelabo
name: National Center for Research Resources (NCRR)
First posted: 2014-01-30
Enrollment: 44
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: This study will determine whether Ataciguat (HMR1766) is well-tolerated in patients with mild to moderate calcific aortic valve stenosis. The primary focus of these studies will be on changes in blood pressure and orthostatic tolerance (i.e., ability to stand up without passing out), and determining whether treatment with Ataciguat results in significant reductions in blood pressure in this patient population.


Eligibility criteria: Inclusion Criteria:

* Age \> 50 years
* Male or female sex
* Aortic valve area greater than 1.0 cm2 but less than 2.0 cm2
* Aortic valve calcium levels greater than 300 arbitrary units from chest CT
* Ejection fraction \>50%

Exclusion Criteria:

* History of orthostatic intolerance or symptomatic hypotension
* Positive pregnancy test during screening visit
* Nitrate use or α-antagonist medication use within 24 hours
* Systolic blood pressure \<110 mm Hg
* Mean systemic arterial pressure \<75 mm Hg
* Severe mitral or aortic regurgitation
* Retinal or optic nerve problems
* Recent (≤30 days) acute coronary syndrome
* Oxygen saturation \<90% on room air
* Congenital valve disease
* Hepatic dysfunction/elevated liver enzymes
* Prescription of drugs known to alter nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate signaling (sildenafil, nitrates, etc.)
* History of orthostatic intolerance
* Concomitant participation in other trials at Mayo Clinic or elsewhere.

Primary outcomes:
measure: Number of patients experiencing orthostatic hypotension
timeFrame: Baseline - 14 days
measure: The change in blood pressure following the transition from sitting to standing
timeFrame: Baseline - 14 days
measure: The change in blood pressure following progressive head-up tilt
timeFrame: Baseline - 14 days
measure: Subject self-reports of light-headedness/orthostatic intolerance during the standing test and the head-up tilt testing
timeFrame: Baseline - 14 days
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Jordan Miller, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06601803: Surgiphor Us in TSA
Official title: Effect of Surgiphor (sterile Povidone-Iodine) Wound Irrigation on Rate of Positive Deep Culture and NGS in Primary Total Shoulder Arthroplasty- a Prospective, Randomized Pilot Study
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: PHASE4
Conditions: Total Shoulder Arthroplasty
Shoulder Infection
Povidone Iodine
Lead sponsor: Rothman Institute Orthopaedics
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 126
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Bacteria is occasionally present in the shoulder during shoulder arthroplasty surgery and is hypothesized to increase the risk of failure of the prosthesis. Surgiphor (sterile Povidone-Iodine) wound irrigation, is a solution used in orthopaedic surgery and other surgical fields to kill bacteria intraoperatively. The Iodine dissociates from complex and has antimicrobial properties, causing cell death of bacteria, fungi, and viruses through interactions with proteins, nucleotides, and fatty acids in the cytoplasm and cytoplasmic membrane.

This study examines the use of Povidone-Iodine during primary shoulder arthroplasty.

Detailed description: The purpose of this study is to determine the rate of reduction of positive cultures collected before and after wound irrigation with either Surgiphor or sterile normal saline during primary total shoulder arthroplasty

Eligibility criteria: Inclusion Criteria:

* Adults age \&gt;18 years
* Participants undergoing elective primary total shoulder arthroplasty
* Participants willing to provide written consent

Exclusion Criteria:

* History of prior surgery to the operative shoulder
* Known allergy to povidone iodine, iodine or shellfish
* active clinical infection
* participation in other clinical trials

Primary outcomes:
measure: Reduction or elimination of bacteria
timeFrame: 90 days
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Rothman Orthopaedic Institute
state: Pennsylvania
Study officials:
References:
Clinical trial NCT05481203: The Effect Of Distraction Methods On Fear And Anxiety In Children Before The Covid 19 Test
Official title: The Effect Of Distraction Methods On Fear And Anxiety In Children Before The Covid 19 Test
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anxiety
Fear
Keywords: COVID-19 test
nasopharyngeal swab collection
pediatric nursing
distraction methods
Lead sponsor: Ondokuz Mayıs University
Sponsor class: OTHER
First posted: 2022-08-01
Enrollment: 114
Sex: ALL
Minimum age (years): 5
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This was an RCT with parallel groups conducted between March, 2022 and August, 2022 at the pediatric emergency unit of a hospital in Black Sea Region Turkey
Primary purpose: SUPPORTIVE_CARE

Brief summary: Aim: This research will be carried out to determine the effect of distracting methods on fear and anxiety in children before the COVID test.

Detailed description: Inroduction: In the literature review, it has been seen that the positive effect of different nanpharmacological methods is supported to reduce pain and anxiety caused by medical procedures. Non-pharmacological methods are classified as physical methods, cognitive behavioral methods, and environmental or emotional intervention methods. In order to draw attention to another direction, which is among these methods; watching cartoons, inflating balloons, creating balloons by blowing foam, talking about things unrelated to the initiative, virtual reality glasses, listening to music, using kaleidoscope and distraction cards etc. is located. The subject of the study is the application of distraction methods in reducing the pain associated with short-term medical interventions.

Eligibility criteria: Inclusion Criteria:

* children who will be taken samples for Covid 19 test
* being between the ages of 5 to 10 years,
* literate

Exclusion Criteria:

* having chronic diseasesvisual
* audio, or speech impairments
* mental disorders,
* history of sedative, analgesic, or narcotic use within 24 h before admission
* inflammatory disease during admission.

Primary outcomes:
measure: changing the anxiety in the Kaleidoscope group
timeFrame: up to 6 months
measure: changing the fear in the Kaleidoscope group
timeFrame: up to 6 months
measure: changing the anxiety in the Visual Illusion Cards group
timeFrame: up to 6 months
measure: changing the fear in the Visual Illusion Cards group
timeFrame: up to 6 months
Secondary outcomes:
measure: changing the "Child Anxiety Scale-Stateness" score
timeFrame: up to 6 months
measure: changing the "Child Fear Scale" score
timeFrame: up to 6 months
Other outcomes:
Locations:
city: Samsun
country: Turkey
facility: Ondokuz Mayis University
state: Atakum
Study officials:
References:
Clinical trial NCT02629003: [11C]Cimbi-36 Dosimetry
Official title: Evaluation of Radiation Dose for [11C]Cimbi-36
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Keywords: Positron Emission Tomography
Serotonin
5-HT2A
Radioligand
Radiation dosimetry
Radiation dosage
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
First posted: 2015-12-11
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to determine the dosimetry for the Positron Emission Tomography (PET) tracer \[11C\]Cimbi-36 in two different Carbon-11 labelling positions. This information will contribute to determining whether \[11C\]Cimbi-36 can be optimized by changing the C-11 labelling position.

Detailed description: Healthy subjects wil undergo a whole-body Positron Emission Tomography (PET) scan with the Serotonin 2A Receptor (5-HT2A) radioligand \[11C\]Cimbi-36 or \[11C\]Cimbi-36-5 to determine the effective radiation dose and radiation dose for selected organs.

Eligibility criteria: Inclusion Criteria:

* 18 years of age
* Signed informed consent

Exclusion Criteria:

* Present or former neurological disease, severe somatic or psychiatric disease, or medication thet can interfere with the test results.
* Pregnancy at the time of the scan
* Breastfeeding
* Alcohol or substance abuse
* Exposure to radiation (\>10 millisievert (mSv)) within the last year, or significant exposure at work
* Allergy to any of the substances in the Investigational medicinal product (IMP) formulation

Primary outcomes:
measure: Effective dose and absorbed dose for selected organs
timeFrame: 0 - 120 minutes
Secondary outcomes:
measure: Measurement of radioactive metabolites in plasma
timeFrame: 0 - 120 minutes
measure: Measurement of radioactivity in plasma and whole blood
timeFrame: 0 - 120 minutes
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Neurobiology Research Unit, Rigshospitalet
Study officials:
affiliation: Neurobiology Research Unit, Rigshospitalet
name: Gitte M Knudsen, MD, DMSc
role: STUDY_CHAIR
References: