louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01527890: Effect of Intravenous Patient-controlled Analgesia (IV-PCA) With Fentanyl in Adults for Acute Postoperative Pain Control
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Nausea
Vomiting
Keywords: intravenous patient-controlled analgesia
IV PCA
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2012-02-07
Enrollment: 2000
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Intravenous Fentanyl Patient-controlled Analgesia for postoperative pain control

Brief summary: In this retrospective study, the investigators examined incidence and risk factors of postoperative nausea and vomiting (PONV) in patients with fentanyl-based intravenous patient-controlled analgesia (IV-PCA).


Eligibility criteria: Inclusion Criteria:

1. Adults between 20 to 60 years old
2. Date from 1st, May 2011 to 31st, October 2011
3. Patients with fentanyl based intravenous patient-controlled analgesia for postoperative pain control

Exclusion Criteria:

1. Reoperation within 48 hours
2. Patients who cannot express numerical rating scale for pain due to sedation

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Gangnam Severance Hospital
Study officials:
References:
Clinical trial NCT00571090: Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid Nodules
Official title: Evaluation of Thyroid Fine Needle Aspiration Biopsies: Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid Nodules
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Thyroid Nodule
Keywords: Thyroid nodule
Biopsy, Fine-Needle
Lead sponsor: Istanbul Science University
Sponsor class: OTHER
Collaborators: name: Group Florence Nightingale
First posted: 2007-12-11
Enrollment: 735
Sex: ALL
Minimum age (years): 15
Maximum age (years): 89
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Endocrinology Clinic

Brief summary: The aim of this study is to identify which ultrasonographic feature or a combination of features is the best predictor of thyroid cancer in thyroid nodules.


Eligibility criteria: Inclusion Criteria:

* Subjects with thyroid nodules over 10 mm in the longest diameter
* Euthyroid or hypothyroid subjects with a solitary thyroid nodule or multinodular goiter
* Subjects with a hypoactive nodule in the thyroid scan and a low TSH

Exclusion Criteria:

* Subjects with four or more thyroid nodules that are over 10 mm
* Subjects with low TSH and hyperactive nodule on thyroid scan

Primary outcomes:
measure: Thyroid cancer
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Group Florence Nightingale
Study officials:
affiliation: Istanbul Science University and Group Florence Nightingale
name: Ahmet Selcuk Can, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Can AS. Cost-effectiveness comparison between palpation- and ultrasound-guided thyroid fine-needle aspiration biopsies. BMC Endocr Disord. 2009 May 16;9:14. doi: 10.1186/1472-6823-9-14.
Clinical trial NCT04448990: Antinociceptive Effect of Transauricular Electrical Vagal Nerve Stimulation
Official title: Antinociceptive Effect of Transauricular Electrical Vagal Nerve Stimulation and Its Underlying Mechanisms
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pain, Acute
Lead sponsor: University Medicine Greifswald
Sponsor class: OTHER
First posted: 2020-06-26
Enrollment: 66
Sex: ALL
Minimum age (years): 19
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Two periods (real and sham tVNS) randomized crossover investigation in healthy volunteers
Primary purpose: BASIC_SCIENCE

Brief summary: This investigation is going to study whether electrical tVNS applied at the cymba of auricular conchae reduces central sensitization of experimentally induced pain in comparison with electrical sham stimulation applied at the earlobes and whether the hypoalgesic effects of tVNS disappear after pharmacological block of muscarinic receptors. Also, this investigation will examine whether tVNS is associated with activation in brain areas, involved in processing of thermal pain stimuli and emotional and vegetative modulation of thermal pain in subjects who will respond with antinociceptive reaction to tVNS.


Eligibility criteria: Inclusion Criteria:

* healthy volunteers aged 18-45 years old, who have given informed consent
* at least two days free from consume of recreational drugs
* no local infection at the site of tVNS and pain stimulation

Exclusion Criteria:

* psychiatric disorders
* abnormal skin conditions (infection, scars, psoriasis, eczema) at the site of tVNS
* contra-indications for MRI (e.g. claustrophobia, pregnancy, tattoos, metallic implants)
* history of coronary heart disease, cardiac arrhythmia, glaucoma, allergy to sulphates

Primary outcomes:
measure: Unpleasantness of pain
timeFrame: Continuously 5 minutes during the experimental heat pain stimulation
Secondary outcomes:
measure: Heart rate
timeFrame: Continuously 5 minutes during the experimental heat pain stimulation
measure: Blood pressure
timeFrame: 4 times during 5 minutes of the experimental heat pain stimulation
Other outcomes:
Locations:
city: Greifswald
country: Germany
facility: University Medicine of Greifswald
Study officials:
References:
Clinical trial NCT03909490: Trigger Finger Preference Elicitation Tool
Official title: Does the Use of a Preference Elicitation Tool at Point of Care in Trigger Finger Change Decisional Conflict?
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Trigger Finger
Trigger Thumb
Trigger Digit
Trigger Finger Disorder
Trigger Thumb, Left Thumb
Trigger Thumb, Right Thumb
Trigger Finger, Ring Finger
Trigger Finger, Index Finger
Trigger Finger, Middle Finger
Trigger Finger, Little Finger
Trigger Thumb, Unspecified Thumb
Trigger Finger, Unspecified Finger
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2019-04-10
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study is to evaluate a patient's level of decisional conflict for their treatment decision regarding their trigger finger, and study if the use of a preference elicitation tool at point of care is able to alter the level of decisional conflict

Detailed description: All patients presenting to the Hand Surgery clinic for evaluation of a new trigger finger will be approached for inclusion in the study. Upon diagnosis, a patient diagnosed with a trigger will be informed of the study, asked if they would like to participate, and consented into the study. Patients will then be randomized to a control group versus our test group. The control group will be given a generic handout about trigger finger and the treatment options. They will then complete the decisional conflict survey without using the tool. The second group will use the tool and then complete the decisional conflict survey.

The standard of care is not being altered- all treatment options will still be available to patients and they have select whatever option is most in line with their preference for treatment. The purpose of the tool is to facilitate preference elicitation for treatment.

Eligibility criteria: Inclusion Criteria:

* diagnosis of trigger finger

Exclusion Criteria:

* prior trigger finger treatment

Primary outcomes:
measure: Decisional Conflict Scale (DCS)
timeFrame: Immediately after visit
Secondary outcomes:
Other outcomes:
Locations:
city: Redwood City
country: United States
facility: Stanford Health Care
state: California
Study officials:
affiliation: Stanford University
name: Robin Kamal
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03408990: Confounding Factors of Impedance Pneumography
Official title: Confounding Factors of Impedance Pneumography Signal Changes During Sleep
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Sleep Apnea
Lead sponsor: Revenio Research
Sponsor class: INDUSTRY
Collaborators: name: Children's Hospital Srebrnjak
First posted: 2018-01-24
Enrollment: 20
Sex: ALL
Minimum age (years): 1
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects referred to sleep laboratory at the investigational site or healthy volunteers from Zagreb and surroundings

Brief summary: The purpose of this study is to evaluate the association of signals recorded and analysed with Ventica® Lung Function Testing System (LFTS) in infants and pre-schoolers during the whole night sleep with the gold standard for sleep recording events, polysomnography, in order to better understand the confounding factors for momentary changes in the impedance pneumography-derived tidal breathing flow-volume (TBFV) curves.


Eligibility criteria: Group 1: (children referred to sleep study for clinical reasons) Inclusion criteria:

* Age 1-7 years, both sexes
* Referred to polysomnography
* Signed informed consent

Group 2: (healthy children) Inclusion criteria:

* 2-7 years, both sexes
* Healthy at the time of inclusion based on history and clinical examination according to the investigator judgement
* Lung function in the reference range
* Signed informed consent

Exclusion Criteria:

* Preterm birth with chronic respiratory disorder of prematurity
* Significant nasal congestion or adenotonsillar hypertrophy with signs and symptoms of sleep apnea or sleep disordered breathing
* Chronic rhinosinusitis, synonasal polyposis
* Personal or family history or clinical evidence of asthma, atopy or other chronic respiratory disorders (high risk for asthma and allergy)
* Use of asthma rescue or maintenance medication within 4 weeks prior to inclusion
* Recurrent bronchitis or recurrent hospitalizations because of a respiratory illness (recurrent pneumonia)
* Hospital-treated for bronchiolitis with residual symptoms
* Acute respiratory infection or hospitalization because of an acute illness within 4 weeks prior to inclusion
* Other cardiorespiratory or neurological chronic diseases or states that may significantly alter the overnight breathing pattern
* Implanted or external active medical devices
* Long lasting respiratory events during the polysomnography study like continuous upper airway limitation

Primary outcomes:
measure: Association between sleep stages and tidal breathing flow-volume (TBFV) curves
timeFrame: 1 night
Secondary outcomes:
measure: Association between body/head positions and tidal breathing flow-volume (TBFV) curves
timeFrame: 1 night
Other outcomes:
Locations:
city: Zagreb
country: Croatia
facility: Children's Hospital Srebrnjak
Study officials:
affiliation: Children's Hospital Srebrnjak
name: Davor Plavec, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01341990: Effect of an Investigational Multi-Purpose Solution on Lens Moisture
Official title: Effect of SiH MPDS FID 114675A vs. a Marketed Multi-Purpose Solution on Lens Moisture
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Contact Lens Moisture
Keywords: Contact Lenses
Contact Lens Care
Multi-Purpose Solution
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
First posted: 2011-04-26
Enrollment: 68
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of the study is to evaluate the effect of an investigational multi-purpose disinfecting solution (MPDS) compared to a marketed multi-purpose solution on the moisture of silicone hydrogel contact lenses.


Eligibility criteria: Inclusion Criteria:

* 18 years of age or older.
* Wears silicone hydrogel contact lenses on a daily wear basis i.e. disinfects lenses every night).
* Has successfully worn contact lenses for 5 days, 8 hours per day, prior to baseline visit.
* Vision is correctable to 20/30 or better in each eye at distance with study lenses at baseline visit.
* Other protocol-specified inclusion criteria may apply.

Exclusion Criteria:

* Known sensitivity or intolerance to contact lens multi-purpose solutions.
* Use of any topical ocular OTC or prescribed topical ocular medications.
* History or current ocular infections or ocular inflammatory events.
* Ocular surgery within the past year.
* Medical condition or use of medication that cause ocular side effects.
* Participation in any investigational study within the past 30 days.
* Other protocol-defined exclusion criteria may apply.

Primary outcomes:
measure: Mean Ex-Vivo Advancing Contact Angle
timeFrame: Day 1, 8 hours
measure: Mean Ex-Vivo Advancing Contact Angle
timeFrame: Day 8, 16 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Fort Worth
country: United States
facility: Contact Alcon Call Center for Trial Locations
state: Texas
Study officials:
affiliation: Alcon Research
name: Justin R Webb, OD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03693690: Factors Affecting Therapeutic Efficacy of Vaginal Laser Therapy for Female Stress Urinary Incontinence, and the Effect of Vaginal Laser Therapy on Overactive Bladder Syndrome and Sexual Function
Official title: Far Eastern Memorial Hospital
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Laser Thermotherapy, Stress Urinary Incontinence
Lead sponsor: Far Eastern Memorial Hospital
Sponsor class: OTHER
First posted: 2018-10-03
Enrollment: 200
Sex: FEMALE
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women with stress urinary incontinence

Brief summary: The main aim of this study is to elucidate factors affecting treatment efficacy of vaginal laser therapy.

Detailed description: Laser thermotherapy can increase the stiffness of vaginal wall. It has been reported that vaginal laser therapy can be used to treat stress urinary incontinence. However, factor affecting treatment efficacy of vaginal laser therapy remains unknown. Thus the main aim of this study is to elucidate factors affecting treatment efficacy of vaginal laser therapy. Besides, the durability of vaginal laser therapy will be assessed. The above knowledge should be helpful for clinical decision making.

Eligibility criteria: Inclusion Criteria:

* \>20 years old female
* had stress urinary incontinence symptoms
* Sexual behavior
* No urinary tract infection
* At their own expense for vaginal laser therapy

Exclusion Criteria:

* Abnormal vaginal bleeding
* Vaginal fistula

Primary outcomes:
measure: Global response assessment
timeFrame: 2 years
Secondary outcomes:
measure: Duration of sustained efficacy
timeFrame: 2 years
Other outcomes:
Locations:
city: New Taipei
country: Taiwan
facility: Department of Obstetrics and Gynecology, Far-Eastern Memorial Hospital
state: Banqiao
Study officials:
References:
Clinical trial NCT06382103: Biomarkers and Molecular Mechanism Study of Hepatocellular Carcinoma After Radical Resection and Conversion Therapy
Official title: Biomarkers and Molecular Mechanism Study of Hepatocellular Carcinoma After Radical Resection and Conversion Therapy
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Hepatocellular Carcinoma
Lead sponsor: Shanghai Zhongshan Hospital
Sponsor class: OTHER
First posted: 2024-04-24
Enrollment: 240
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study will enroll male and female subjects with HCC treated with definitive surgery,with or without neoadjuvant therapy.

Brief summary: Blood samples will be tested to identify circulating tumor DNA and plasma protein levels to potentially improve prediction of long term prognosis and guide treatment options of patients with hepatocellular carcinoma underwent surgical resection.


Eligibility criteria: Inclusion Criteria:

* Patients with a first diagnosis of HCC.
* Patients with HCC who are to undergo surgical treatment, with or without neoadjuvant therapy.
* Ability to obtain tissue sample for ctDNA analysis and detectable baseline ctDNA level.

Exclusion Criteria:

* Patients with secondary liver cancer, or intrahepatic cholangiocarcinoma.
* Any other concurrent malignancy.
* History of organ transplant or hepatic encephalopathy.

Primary outcomes:
measure: Correlation between ctDNA level and recurrence-free survival (RFS)
timeFrame: 1 years
measure: Correlation between specific plasma protein expression level and recurrence-free survival (RFS)
timeFrame: 1 years
Secondary outcomes:
measure: Correlation between tumor mutation numbers and recurrence-free survival (RFS)
timeFrame: 1 years
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Zhongshan Hospital Fudan University
Study officials:
References:
Clinical trial NCT06354803: Effect of Pezzi Ball on Balance in Pregnant Women
Official title: Amelioration of Kinaesthesia in Pregnant Women Using Pezzi Ball Exercises: Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Postural Stability
Keywords: Kinaesthetic training
Lead sponsor: Kafrelsheikh University
Sponsor class: OTHER
First posted: 2024-04-09
Enrollment: 45
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 45 participants with gestational age below 28 weeks
Primary purpose: SUPPORTIVE_CARE

Brief summary: The effect of kinaesthetic training on performance and postural stability during pregnancy and 2 weeks postpartum

Detailed description: The effect of kinaesthetic training using pezzi ball for 12 sessions with rate of 3 session per week on postural stability and performance during pregnancy and at the 2-week postpartum follow-up. Postural stability was measured using a balance check board 636-1

Eligibility criteria: Inclusion Criteria:

* age between 25 and 30 years a body mass index (BMI) not exceeding 32 kg/m2, low-risk gestation primiparous pregnancy intact sensory motor integration in the lower extremities.

Exclusion Criteria:

* more than 28 weeks gestation
* had chronic disease
* multiparous

Primary outcomes:
measure: change of postural stability
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Kafr Ash Shaykh
country: Egypt
facility: Faculty of physical therapy kafrelshiekh university
state: Kafrelshiekh
Study officials:
References:
Clinical trial NCT01178203: The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Pulpitis
Pain Management
Keywords: Endodontics
pain
visual analogue scale
NSAIDs
Lead sponsor: Azad University of Medical Sciences
Sponsor class: OTHER
First posted: 2010-08-10
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aim: eliminating or reducing pain following endodontic treatment is of great importance. The aim of this study is to compare the effects of Tramadol, Novafen and Naproxen on post-operative pain following instrumentation of root canals in teeth with irreversible pulpitis. Sample size: one hundred patients considering the inclusion and exclusion criteria were selected. Intervention and outcome: The effect of Tramadol, Novafen and Naproxen on post-operative pain following instrumentation of root canals in teeth with irreversible pulpitis was evaluated.


Eligibility criteria: Inclusion Criteria:

1. The subjects were 20-60 years of age with no systemic diseases and females were not pregnant;
2. No history of taking any analgesics or other drugs prior to presenting for treatment;
3. Patients had moderate to severe pain associated with irreversible pulpitis in single-rooted premolars or anterior teeth.

Exclusion Criteria:

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04127903: The Length of the Right Main Stem Bronchus as a Guide to Right-sided Double-lumen Tube Use
Official title: The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, China.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Therapeutic Procedural Complication
Lead sponsor: The First Hospital of Qinhuangdao
Sponsor class: OTHER_GOV
First posted: 2019-10-16
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: OTHER

Brief summary: The Length of the Right Main Stem Bronchus Measured by Computerised Tomography as a Guide to Right-sided Double-lumen Tube Use

Detailed description: The double lumen tube (DLT) is the most popular way to isolate the lungs for thoracic surgery. The variable anatomy of the length of the right main stem bronchus seems to be the main reason clinicians are unwilling to use the right-sided DLT (R-DLT). The factors that could compromise the adequate ventilation of the right lung are mostly the variable length of the Right Main Stem Bronchus and the misalignment of the lateral orifice of the right-sided DLT in regard to the right upper lobe bronchus (RULB). The objectives of this study were to validate an alternative method to estimate the length of the Right Main Stem Bronchus by Computerised Tomography as a Guide to Right-sided Double-lumen Tube Use

Eligibility criteria: Inclusion Criteria:

* Adult patients undergoing thoracic surgery

Exclusion Criteria:

1. Age\>70 or \<18 years
2. ASA classifications \>III
3. BMI \>35kg/m2
4. Modified Mallampati classification ≥III
5. Thoracic surgery within the last one month
6. Severe cardiopulmonary disease

Primary outcomes:
measure: The incidence of Uniblocker displacement
timeFrame: 1 year
measure: The number of adjust the right-sided double-lumen tube to optimum location
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Qinhuangdao
country: China
facility: The first hospital of Qinhuangdao
state: Hebei
Study officials:
affiliation: The First Hospital of Qinhuangdao
name: Ximing Qi
role: STUDY_DIRECTOR
References:
citation: Liu Z, Liu M, Zhao L, Qi X, Yu Y, Liang S, Yang X, Ma Z. Comparison of the accuracy of three methods measured the length of the right main stem bronchus by chest computed tomography as a guide to the use of right sided double-lumen tube. BMC Anesthesiol. 2022 Aug 18;22(1):264. doi: 10.1186/s12871-022-01744-z.