Clinical trial NCT06428890: Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension
Official title: Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prehypertension
Lead sponsor: California Baptist University
Sponsor class: OTHER
First posted: 2024-05-24
Enrollment: 12
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study aimed to assess the effect of the supplementation with grape seed extract (GSE) on blood pressure during static handgrip exercise and muscle metaboreflex in individuals with elevated and state 1 hypertension.

Detailed description: Muscle metatoreflex (MMR) has been known to play an important role in adjusting hemodynamic responses during exercise. The reflex increases sympathetic activity to heart and blood vessels to increase blood supply to contracting skeletal muscles. On the other hand, studies demonstrated that abnormal cardiovascular responses occurred by the overactive MMR in pathological conditions such as hypertension, diabetes, and congestive heart failure. Excessive blood pressure (BP) responses to exercise induce cardiovascular events such as stroke, heart attack, and coronary artery disease. Previously, a study found that dietary supplementation with grape seed extract (GSE) reduced BP response to dynamic exercise in individuals with elevated and stage 1 hypertension (ES1H) and associated with peripheral vasodilation. However, mechanisms underlying this phenomenon are not clear. Purpose: therefore, the purpose of this study is to investigate whether chronic dietary supplementation with GSE can decrease BP responses to exercise and this observation is associated with reduced MMR. Methods: 12 ES1H males were studied. Changes in cardiac output (Q), mean arterial pressure (MAP) and total peripheral resistance (TPR) were compared between the GSE and placebo supplementations during static handgrip exercise (SHE) and post exercise muscular ischemia (PEMI). Participants completed 3 min of SHE at 40% of MVC followed by 2 min of PEMI.

Eligibility criteria: Inclusion Criteria:

* systolic blood pressure: 120-139 mmHg and/or a diastolic blood pressure: 80-89 mmHg

Exclusion Criteria:

* taking medications that could affect cardiovascular function or BP

Primary outcomes:
measure: heart rate (bpm)
timeFrame: 5 minutes, 3 minutes, and 2 minutes, respectively.
measure: stroke volume (ml)
timeFrame: 5 minutes, 3 minutes, and 2 minutes, respectively.
measure: cardiac output (l/min)
timeFrame: 5 minutes, 3 minutes, and 2 minutes, respectively.
measure: systolic blood pressure (mmHg)
timeFrame: 5 minutes, 3 minutes, and 2 minutes, respectively.
measure: diastolic blood pressure (mmHg)
timeFrame: 5 minutes, 3 minutes, and 2 minutes, respectively.
measure: total peripheral resistance (mmHg/l/min)
timeFrame: 5 minutes, 3 minutes, and 2 minutes, respectively.
Secondary outcomes:
Other outcomes:
Locations:
city: Riverside
country: United States
facility: California Baptist University
state: California
Study officials:
affiliation: California Baptist University
name: Jong-Kyung Kim, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: