louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03747302: HPV Message Testing and Social Media Campaign
Official title: HPV Message Testing and Social Media Campaign
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vaccine
Human Papilloma Virus
Keywords: Adolescence
Attitudes
Parents
Vaccination
Lead sponsor: Dartmouth-Hitchcock Medical Center
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
name: Norris Cotton Cancer Center
First posted: 2018-11-20
Enrollment: 1043
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This project involves a social media campaign to increase parent's knowledge and acceptance of the HPV (human papillomavirus) vaccine. The current vaccine protects against nine types of HPV, including seven that are known to cause cancer. The Centers for Disease Control and Prevention (CDC) estimates that the current HPV vaccine could prevent 90% of cancer cases caused by HPV, including cases of cervical cancer, oropharyngeal (mouth and throat) cancer, anal cancer, and others. About 150 and 104 cases of HPV-associated cancers are diagnosed each year in New Hampshire and Vermont, respectively-many of which could be prevented through vaccination. Currently, only 49.8% of New Hampshire adolescents and 44.3% of Vermont adolescents were not up-to-date for HPV vaccination as of 2016. This social media campaign is testing a set of campaign messages with parents locally and nationally to see which messages are most effective in improving their knowledge and acceptance of the vaccine. A study survey link will monitor the number of people reached and will measure parental intention to get their children vaccinated against HPV.


Eligibility criteria: Inclusion Criteria:

* parents of children 9-14 years old

Exclusion Criteria:

* non-parents

Primary outcomes:
measure: Change in Attitudes About HPV Vaccine
timeFrame: Post test completed < 1 hour post messaging intervention
Secondary outcomes:
measure: Behavioral Intention to Vaccinate Their Child With HPV Vaccine
timeFrame: Ore test immediately before viewing message and post- test immediately after viewing message. Approximately one hour.
Other outcomes:
Locations:
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center
state: New Hampshire
Study officials:
affiliation: Trustees of Dartmouth College
name: Ardis L Olson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03964402: Sample Size for Multivariate Time-to-event Data
Official title: Sample Size Determination in Heterogeneous Populations for Multivariate Time-to-event Data
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Clinical Trials
Keywords: sample size, survival, randomized clinical trials, statistical test
Lead sponsor: Institut Bergonié
Sponsor class: OTHER
Collaborators: name: Institut National de la Santé Et de la Recherche Médicale, France
First posted: 2019-05-28
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: to be adapted to the indication under investigation

Brief summary: Most of randomized clinical trials (RCT) using time-to-event criteria as the primary endpoint are designed, powered and analyzed based on an hypothetical hazard ratio (HR) corresponding to the targeted effect size between experimental and control arms. Usually, one assumes that populations are homogeneous within each treatment arm, that is, within each arm, (i) the baseline risk is identical for all patients, and (ii) the treatment effect is identical for all patients. This assumption however may not hold in all circumstances. This project aims at providing a statistical method for the estimation of sample size in RCT, in the presence of heterogenous populations, such as assuming populations with distinct underlying baseline risks or assuming different treatment effects.


Eligibility criteria: Inclusion Criteria:

* not applicable

Exclusion Criteria:

* not applicable

Primary outcomes:
measure: Overall survival
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: Institut Bergonié, Comprehensive Cancer Center
Study officials:
affiliation: Institut Bergonié
name: Carine Bellera, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01942902: A Comparative Study to Evaluate the Accuracy and Safety of the GlySure Continuous Intravascular Glucose Monitoring System Versus Intermittent Blood Glucose Monitoring
Official title: A Comparative Study to Evaluate the Accuracy and Safety of the GlySure Continuous Intravascular Glucose Monitoring System Versus Intermittent Blood Glucose Monitoring Using the Yellow Springs Blood Glucose Analyser for Conformité Européenne (CE) Marking Purposes in a Total of Thirty Patients Admitted to The Surgical Intensive Care Unit (SICU)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Continuous Glucose Measurement
Lead sponsor: GlySure
Sponsor class: INDUSTRY
First posted: 2013-09-16
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the system performance of the GlySure Continuous Glucose Monitoring (CGM) system in patients admitted to the Surgical Intensive Care Unit.


Eligibility criteria: Inclusion Criteria:

1. Patient or legal representative MUST be willing to sign an informed consent document
2. Male and female aged 18 years and above
3. Require Central Venous Catheter (CVC) into the right internal Jugular vein as part of disease management and treatment
4. Expected to remain in the Surgical Intensive Care Unit (SICU) for at least 30 hours and up to 7 days-

Exclusion Criteria:

1. Patient or legal representative unable to provide written informed consent
2. Patient who is pregnant
3. Patient who is currently being administered Mannitol
4. Patient with history of Pulmonary Embolism (PE)
5. Patient with history of thrombosis
6. Patient with known hyper-coagulation
7. Patient with known history of heparin hypersensitivity
8. Patient with history of heparin induced thrombocytopenia
9. Participation in a clinical study involving an unlicensed pharmaceutical product and/or device within the 3 months prior to enrolment in this study
10. Patient with known hypersensitivity/allergy to adhesive I.V. dressings such as 3M Tegaderm film
11. Patient likely to require an MRI scan during their stay in the SICU
12. Patients likely to require treatment with Mannitol during time in the SICU

Primary outcomes:
measure: Accuracy of the CGM system as compared with the Yellow Springs Instrument (YSI) blood sample analysis results
timeFrame: For at least 30 hours and up to 7 days
measure: Number of participants experiencing Serious Adverse Events (SAEs) causally related to the devices
timeFrame: For at least 30 hours and up to 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Banjara Hills
country: India
facility: Star Hospital
state: Hyderabad
city: Nampally
country: India
facility: Care Hospital
state: Hyderabad
Study officials:
affiliation: Care Hospital
name: Krishna Prasad, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06842602: Evaluation of Gastric Volume and pH Changes in Gastroscopy Patients
Official title: Evaluation of Gastric Volume and pH Changes in Gastroscopy Patients Using Chewing Gum and Candy: Prospective Randomized Double-Blind Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Gastroscopy
Keywords: gastric pH
gastric residual volume
gastroscopy
candy
gum
preoperative fasting rules
Lead sponsor: Bursa Yüksek İhtisas Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2025-02-24
Enrollment: 405
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Pulmonary aspiration is a rare but serious complication that can result in 57% mortality and 14% permanent damage. Fasting rules (solid foods 6-8 hours, clear liquids 2 hours) determined by anesthesia associations are applied to prevent pulmonary aspiration by reducing gastric volume. Gastric volume (≥ 0.5 mL/kg) and pH (\<2.5) values are shown to be determinants in the occurrence of pulmonary complications .

Detailed description: The hypothesis of this study was that preprocedure candy and chewing gum use may have no effects on gastric residual volume and pH. For this purpose, we analyzed the gastric residual volume and gastric pH values of patients who were given gum and candy before the procedure.

Eligibility criteria: Inclusion Criteria:

* ASA I-III,
* oriented
* cooperative
* scheduled for elective gastroscopy

Exclusion Criteria:

* body mass index is (BMI) \>30 kg/m2,
* full stomach predicted patients (obstruction, stenosis, bleeding, ascites, urgency),
* patients with diabetes
* patients with who underwent bowel cleansing
* patients who did not want to give consent to participate

Primary outcomes:
measure: Gastric volume
timeFrame: baseline
measure: Gastric pH measurements
timeFrame: baseline
Secondary outcomes:
measure: endoscopist satisfaction
timeFrame: baseline
measure: general procedure satisfaction
timeFrame: baseline
measure: Complication
timeFrame: Perioperative
Other outcomes:
Locations:
city: Bursa
country: Turkey
facility: Mehmet Fatih Erol
Study officials:
affiliation: Bursa Yuksek ıhtısas tra
name: Mehmet fatih erol, M.D
role: STUDY_DIRECTOR
affiliation: Bursa Yuksek Ihtısas tranin and research hospital
name: Füsun gözen, M.D
role: STUDY_DIRECTOR
References:
Clinical trial NCT06739902: Comparing the Effectiveness of Traditional Physiotherapy Combined With Virtual Reality for Post-Stroke Patients
Official title: Comparing the Effectiveness of Traditional Physiotherapy Combined With Virtual Reality for Post-Stroke Patients
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Stroke
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-12-18
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study aims to evaluate the effectiveness of combining virtual reality (VR) therapy with traditional physiotherapy in post-stroke rehabilitation. Post-stroke patients often suffer from impairments in motor function, balance, and overall quality of life. While traditional physiotherapy is a widely accepted method for stroke recovery, incorporating VR technology may enhance treatment outcomes by providing an engaging, immersive environment that motivates patients to perform therapeutic movements.

Detailed description: This study will compare the functional and quality-of-life improvements in patients undergoing traditional physiotherapy alone versus those receiving a combination of conventional physiotherapy and VR interventions. By assessing changes in motor function, trunk stability, balance, and quality of life, this research will provide valuable insights into whether VR can be an effective adjunctive tool in post-stroke rehabilitation programs.

Eligibility criteria: Inclusion Criteria:

* Stroke, either ischemic or hemorrhagic
* Participants who can ambulate independently or with minimal assistance.
* Participants who were willing \& able to adhere to the study protocol.
* Including participants who were attending follow-up appointments \& completing outcome measures.
* Participants who were able to understand \& provide written informed consent

Exclusion Criteria:

* Existence of additional neurological disorders (such as multiple sclerosis or Parkinson's disease) or serious medical conditions that could prevent participants from participating in the study.
* Participants receiving rehabilitation or rigorous physical treatment in the previous three months were excluded.
* Pregnant women or breastfeeding women.
* Participants who refused to participate in the study or provide informed consent.

Primary outcomes:
measure: Berg Balance Scale (BBS)
timeFrame: 12 Months
measure: Trunk Impairment Scale (TIS)
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Services Hospital, Shadman 1
state: Punjab
Study officials:
References:
Clinical trial NCT05828602: Pulmonary Rehabilitation Through Tele Rehabilitation for COPD in Pakistan
Official title: Feasibility of Pulmonary Rehabilitation Through Tele Rehabilitation Versus Traditional Center Based Pulmonary Rehabilitation for COPD in Pakistan
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-04-25
Enrollment: 40
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To determine the feasibility of Tele-rehabilitation vs traditional center-based pulmonary rehabilitation for people with chronic obstructive pulmonary disease


Eligibility criteria: Inclusion Criteria:

* have a primary diagnosis of a chronic obstructive pulmonary disease
* aged ≥40 years
* be able to read and speak Urdu
* Vitally stable
* both gender

Exclusion Criteria:

* Inability to use technology, inadequate home setting, and patient's refusal.
* pulmonary hypertension or lung cancer attended pulmonary rehabilitation within the previous 18 months and had no hospitalizations for a respiratory cause since rehabilitation completion
* oxygen desaturation resulting in cessation of cardiopulmonary exercise testing (e.g. SpO2 \&lt; 80% during exercise on cycle ergometer)
* to ensure safety of unsupervised training
* unstable or brittle asthma with a hospital admission or emergency department presentation within the preceding 3 months, to ensure safety of unsupervised training
* co-morbidities which preclude exercise training, such as neurological or musculoskeletal impairment
* unable to follow verbal instructions, suffer from cognitive impairment, or have language difficulties

Primary outcomes:
measure: Chronic respiratory questionnaire
timeFrame: 40 Days
measure: Physical activity via IPAQ
timeFrame: 40 Days
measure: Quality of life - Sf 12
timeFrame: 40 Days
measure: Body mass index
timeFrame: 40 Days
measure: Borg Scale
timeFrame: 40 Days
measure: Level of satisfaction scale
timeFrame: 40 Days
measure: Self-Structure open ended Questions
timeFrame: 40 Days
Secondary outcomes:
Other outcomes:
Locations:
city: Peshawar
country: Pakistan
facility: Hayatabad Medical Complex
state: Khyber PkahtoonKhwa
Study officials:
affiliation: Riphah International University
name: Muhammad Iqbal Tariq, PhD*
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05208502: Observational of Emergence Time Between Patients Receive General Anesthesia With BIS or Spectrogram EEG Monitor
Official title: Observation of Emergence Time Between Patients Receive General Anesthesia With BIS or 4-channel Spectrogram EEG Monitor
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: General Anesthetic Drug Adverse Reaction
Perioperative/Postoperative Complications
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2022-01-26
Enrollment: 126
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients who need routine general anesthesia

Brief summary: The bispectral index parameter is used to guide the titration of general anesthesia, however; conflicting results between different studies cannot prove the benefit of EEG monitor on improvement of OR efficiency. Next Generation SedLine features an enhanced signal processing engine, which provides processed EEG parameters. This four channel EEG monitor for the monitoring of perioperative anesthesia depth prevent overdose of medication and may help for individualized anesthetic plan. This research intended to observe the emergence time from end of the surgical wound closure to patient awake (or to extubation) with or without SedLine.

Detailed description: This is a clinical observation study. Inclusion criteria are patients with ASA 1-3, age over 20 who need general anesthesia surgery without other neurologic disease. All inclusions will receive the general anesthesia with SedLine monitor, a researcher who is not participated in the clinical practice will record the emergence characters and the EEG monitor signal. The Controls were patients with same criteria without BIS monitor. Sample size was decided if the estimated difference between SedLine group and BIS group are 1 minute and the average estimated as 2 minute. With 80% desired power and default is .05, each group will need 63 cases.

Eligibility criteria: Inclusion Criteria:

* patients who need routine general anesthesia
* have no neurological problem
* have no dermo issue over forehead area
* not allergic to the patch

Exclusion Criteria:

* patients who is not agreed

Primary outcomes:
measure: DSA monitor group has less emergence time
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: Operation Theater, National Taiwan University Hospital
name: Feng-Fang Tsai, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04150302: Development and Validation of a Questionnaire to Measure the Impact of SBS and Its Treatments on Patients' Lives
Official title: Development and Validation of a Questionnaire to Measure the Impact of Short Bowel Syndrome (SBS) and Its Treatments on Patients' Lives
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: SBS - Short Bowel Syndrome
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
Collaborators: name: Beaujon Hospital
name: Société Francophone Nutrition Clinique et Métabolisme
First posted: 2019-11-04
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients over 18 years with SBS for more than 6 months and returned home for at least 3 months.

Brief summary: Today, patients express a very strong need to take into account the consequences of their disease and its treatments in their therapeutic follow-up. It is therefore essential to better understand the needs, expectations and values of patients with SBS in order to better understand the impact of the disease on their lives, and thus improve the conditions for medical, social, psychological and technical care. The clinical expertise of health professionals and meetings with patient associations demonstrate the major gap between the parameters taken into account by physician to evaluate the evolution of the SBS and the day-to-day experience of the disease perceived by the patient.

The objective of the ARTEMIS-GC study is to develop and validate an instrument to measure the impact of SBS and its treatments on daily life from the perspective of patients.


Eligibility criteria: Inclusion Criteria:

* Patients with SBS defined by a hail length remaining in post-duodenal \< 2 meters
* Patients with intestinal insufficiency, i.e. chronic malabsorption requiring energetic and/or hydro-electrolytic intravenous support for more than 6 months
* Patients with a period of at least 6 months after the establishment of the SBS
* Patients who has already had a return home after the establishment of the SBS for a period of at least 3 months

Exclusion Criteria:

* Patients with intestinal insufficiency but with a cause other than SBS
* Lack of understanding of the study
* Not speaking French

Primary outcomes:
measure: Scale calibration of the new developped questionnaire
timeFrame: about 30 minutes
measure: Structure of the new developped questionnaire
timeFrame: about 30 minutes
measure: Convergence proprieties of the new developped questionnaire
timeFrame: about 30 minutes
measure: Reproducibility of the new developped questionnaire
timeFrame: Up to 8 days
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Beaujon Hospital
Study officials:
References:
Clinical trial NCT02178202: McKenzie Exercise Vs Harmonic Technique in Chronic Low Back Pain
Official title: Prescription of Two Exercise Therapy Protocols for Treating Chronic Low Back Pain
Study type: EXPANDED_ACCESS
Overall status: NO_LONGER_AVAILABLE
Conditions: Low Back Pain
Keywords: Harmonic technique, Low Back Pain, McKenzie exercise, Pain, Disability
Lead sponsor: University of Tehran
Sponsor class: OTHER
First posted: 2014-06-30
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT

Brief summary: The purpose of this study was to investigate the effects of HT compared with McK exercise on pain and disability in patients with LBP.


Eligibility criteria: Inclusion Criteria:

* Had persistent back pain at least eight weeks or during the last year subjects must suffer from LBP at least three times and each time lasted more than a week.

Exclusion Criteria:

* Had a history of fracture or surgery in the spine, pelvis and lower extremities through last year
* History of neuromuscular disease
* The referral and radicular pain in the lower extremities and neurological or sensory disturbance in the lower extremities
* Urinary incontinence and pain severity higher that 7 based on visual analogue scale (VAS)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: