Clinical trial NCT03280303: Palbociclib in Real World Practice
Official title: POLARIS: PALBOCICLIB IN HORMONE RECEPTOR POSITIVE ADVANCED BREAST CANCER: A PROSPECTIVE MULTICENTER NON-INTERVENTIONAL STUDY
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Advanced Breast Cancer
Metastatic Breast Cancer
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2017-09-12
Enrollment: 1285
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: HR+/HER2- ABC patients whose treatment decision with palbociclib has been made by their treating physician and who meet the eligibility criteria will be invited to participate in the study.

Brief summary: This Non-Interventional Study will describe and analyze the clinical use of palbociclib in routine clinical practice in the treatment of advanced breast cancer.


Eligibility criteria: Inclusion Criteria

1. Age ≥18 years or older.
2. Diagnosis of adenocarcinoma of the breast with evidence of metastatic disease or advanced disease not amenable to treatment with curative intent.
3. Documented HR+ (ER+ and/or PR+) tumor based on local standards.
4. Documented HER2- tumor based on local standards.
5. Physician has determined that treatment with palbociclib is indicated.
6. Evidence of a personally signed and dated informed consent document indicating that the patient has been informed of all pertinent aspects of the study.
7. Patients who in the opinion of the investigator are willing and able to comply with regular clinic visits as per standard of care practice at the site.

Exclusion Criteria:

1. Patients with a life expectancy of less than 3 months at the time of ABC diagnosis, per the investigator's judgment.
2. Patients participating in any interventional clinical trial that includes investigational or marketed products at the time of enrollment. (Patients participating in other investigator initiated research or NIS can be included as long as their standard of care is not altered by the study).
3. Patients on active treatment for malignancies other than ABC at the time of enrollment.
4. Patients who are unable to understand the nature of the study and are unwilling to sign an informed consent.

   -

Primary outcomes:
measure: Number of Participants According to Real-World Tumor Response
timeFrame: From start of palbociclib combination treatment until first documentation of progression (up to approximately 3 years)
measure: Real-World Tumor Response Rate
timeFrame: From start of palbociclib combination treatment until first documentation of progression (up to approximately 3 years)
measure: Real World Progression Free Survival
timeFrame: From initiation of the palbociclib combination treatment to the earliest of clinician-documented progression or death due to any cause, whichever occurs first. (up to approximately 3 years)
measure: Overall Survival
timeFrame: From initiation of the palbociclib combination treatment to death due to any cause or censored, (up to approximately 3 years)
measure: Absolute Eastern Co-Operative Oncology Group (ECOG) Performance Status Scores at Baseline: Participants More Than or Equal to 70 Years Only
timeFrame: Baseline (last observed measurement prior to treatment start date)
measure: ECOG Performance Status Scores at Month 1: Participants More Than or Equal to 70 Years Only
timeFrame: Month 1
measure: ECOG Performance Status Scores at Month 2: Participants More Than or Equal to 70 Years Only
timeFrame: Month 2
measure: ECOG Performance Status Scores at Month 3: Participants More Than or Equal to 70 Years Only
timeFrame: Month 3
measure: ECOG Performance Status Scores at Month 6: Participants More Than or Equal to 70 Years Only
timeFrame: Month 6
measure: ECOG Performance Status Scores at Month 9: Participants More Than or Equal to 70 Years Only
timeFrame: Month 9
measure: ECOG Performance Status Scores at Month 12: Participants More Than or Equal to 70 Years Only
timeFrame: Month 12
measure: ECOG Performance Status Scores at Month 15: Participants More Than or Equal to 70 Years Only
timeFrame: Month 15
measure: ECOG Performance Status Scores at Month 18: Participants More Than or Equal to 70 Years Only
timeFrame: Month 18
measure: ECOG Performance Status Scores at Month 21: Participants More Than or Equal to 70 Years Only
timeFrame: Month 21
measure: ECOG Performance Status Scores at Month 24: Participants More Than or Equal to 70 Years Only
timeFrame: Month 24
measure: ECOG Performance Status Scores in Month 27: Participants More Than or Equal to 70 Years Only
timeFrame: Month 27
measure: ECOG Performance Status Scores at Month 30: Participants More Than or Equal to 70 Years Only
timeFrame: Month 30
measure: ECOG Performance Status Scores at Month 33: Participants More Than or Equal to 70 Years Only
timeFrame: Month 33
measure: ECOG Performance Status Scores in Month 36: Participants More Than or Equal to 70 Years Only
timeFrame: Month 36
measure: ECOG Performance Status Scores at Month 39: Participants More Than or Equal to 70 Years Only
timeFrame: Month 39
measure: ECOG Performance Status Scores at Month 42: Participants More Than or Equal to 70 Years Only
timeFrame: Month 42
measure: Geriatric 8 Screening Tool Scores at Baseline: Participants More Than or Equal to 70 Years Only
timeFrame: Baseline (last observed measurement prior to treatment start date)
measure: Geriatric 8 Screening Tool Scores at Month 1: Participants More Than or Equal to 70 Years Only
timeFrame: Month 1
measure: Geriatric 8 Screening Tool Scores at Month 2: Participants More Than or Equal to 70 Years Only
timeFrame: Month 2
measure: Geriatric 8 Screening Tool Scores at Month 3: Participants More Than or Equal to 70 Years Only
timeFrame: Month 3
measure: Geriatric 8 Screening Tool Scores at Month 6: Participants More Than or Equal to 70 Years Only
timeFrame: Month 6
measure: Geriatric 8 Screening Tool Scores at Month 9: Participants More Than or Equal to 70 Years Only
timeFrame: Month 9
measure: Geriatric 8 Screening Tool Scores at Month 12: Participants More Than or Equal to 70 Years Only
timeFrame: Month 12
measure: Geriatric 8 Screening Tool Scores at Month 15: Participants More Than or Equal to 70 Years Only
timeFrame: Month 15
measure: Geriatric 8 Screening Tool Scores at Month 18: Participants More Than or Equal to 70 Years Only
timeFrame: Month 18
measure: Geriatric 8 Screening Tool Scores at Month 21: Participants More Than or Equal to 70 Years Only
timeFrame: Month 21
measure: Geriatric 8 Screening Tool Scores at Month 24: Participants More Than or Equal to 70 Years Only
timeFrame: Month 24
measure: Geriatric 8 Screening Tool Scores at Month 27: Participants More Than or Equal to 70 Years Only
timeFrame: Month 27
measure: Geriatric 8 Screening Tool Scores at Month 30: Participants More Than or Equal to 70 Years Only
timeFrame: Month 30
measure: Geriatric 8 Screening Tool Scores at Month 33: Participants More Than or Equal to 70 Years Only
timeFrame: Month 33
measure: Geriatric 8 Screening Tool Scores at Month 36: Participants More Than or Equal to 70 Years Only
timeFrame: Month 36
measure: Geriatric 8 Screening Tool Scores at Month 39: Participants More Than 70 or Equal to Years Only
timeFrame: Month 39
measure: Geriatric 8 Screening Tool Scores at Month 42: Participants More Than or Equal to 70 Years Only
timeFrame: Month 42
measure: Change From Baseline to Month 6 in European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Scores at Baseline
timeFrame: Baseline (last observed measurement prior to treatment start date) and Month 6
measure: Change From Baseline to Month 12 in European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Scores at Baseline
timeFrame: Baseline (last observed measurement prior to treatment start date) and Month 12
measure: Change From Baseline to Month 18 in European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Scores at Baseline
timeFrame: Baseline (last observed measurement prior to treatment start date) and Month 18
measure: Activities of Daily Living Scores at Baseline: Participants More Than or Equal to 70 Years Only
timeFrame: Baseline (last observed measurement prior to treatment start date)
measure: Activities of Daily Living Scores at Month 1: Participants More Than or Equal to 70 Years Only
timeFrame: Month 1
measure: Activities of Daily Living Scores at Month 2: Participants More Than or Equal to 70 Years Only
timeFrame: Month 2
measure: Activities of Daily Living Scores at Month 3: Participants More Than or Equal to 70 Years Only
timeFrame: Month 3
measure: Activities of Daily Living Scores Month 6: Participants More Than or Equal to 70 Years Only
timeFrame: Month 6
measure: Activities of Daily Living Scores at Month 9: Participants More Than or Equal to 70 Years Only
timeFrame: Month 9
measure: Activities of Daily Living Scores at Month 12: Participants More Than or Equal to 70 Years Only
timeFrame: Month 12
measure: Activities of Daily Living Scores at Month 15: Participants More Than or Equal to 70 Years Only
timeFrame: Month 15
measure: Activities of Daily Living Scores at Month 18: Participants More Than or Equal to 70 Years Only
timeFrame: Month 18
measure: Activities of Daily Living Scores at Month 21: Participants More Than or Equal to 70 Years Only
timeFrame: Month 21
measure: Activities of Daily Living Scores at Month 24: Participants More Than or Equal to 70 Years Only
timeFrame: Month 24
measure: Activities of Daily Living Scores at Month 27: Participants More Than or Equal to 70 Years Only
timeFrame: Month 27
measure: Activities of Daily Living Scores at Month 30: Participants More Than or Equal to 70 Years Only
timeFrame: Month 30
measure: Activities of Daily Living Scores at Month 33: Participants More Than or Equal to 70 Years Only
timeFrame: Month 33
measure: Activities of Daily Living Scores at Month 36: Participants More Than or Equal to 70 Years Only
timeFrame: Month 36
measure: Activities of Daily Living Scores at Month 39: Participants More Than or Equal to 70 Years Only
timeFrame: Month 39
measure: Activities of Daily Living Scores at Month 42: Participants More Than or Equal to 70 Years Only
timeFrame: Month 42
measure: Number of Participants With Adverse Events
timeFrame: From start of palbociclib treatment or date of informed consent until 28 days after last dose of study treatment (up to approximately 3 years)
measure: Number of Participants With Serious Adverse Events
timeFrame: From start of palbociclib treatment or date of informed consent until 28 days after last dose of study treatment (up to approximately 3 years).
measure: Number of Participants With Any Clinical Laboratory Abnormalities
timeFrame: From start of palbociclib treatment or date of informed consent until 28 days after last dose of study treatment (up to approximately 3 years).
Secondary outcomes:
Other outcomes:
Locations:
city: Alabaster
country: United States
facility: Alabama Oncology
state: Alabama
city: Bessemer
country: United States
facility: Alabama Oncology
state: Alabama
city: Birmingham
country: United States
facility: Alabama Oncology
state: Alabama
city: Birmingham
country: United States
facility: Alabama Oncology
state: Alabama
city: Birmingham
country: United States
facility: Alabama Oncology
state: Alabama
city: Birmingham
country: United States
facility: Alabama Oncology
state: Alabama
city: Birmingham
country: United States
facility: Grandview Cancer Center, Alabama Oncology
state: Alabama
city: Birmingham
country: United States
facility: University of Alabama at Birmingham Comprehensive Cancer Center
state: Alabama
city: Birmingham
country: United States
facility: The University of Alabama at Birmingham
state: Alabama
city: Little Rock
country: United States
facility: Central Arkansas Radiation Therapy Institute
state: Arkansas
city: Stuttgart
country: United States
facility: Central Arkansas Radiation Therapy Institute
state: Arkansas
city: Auburn
country: United States
facility: Sutter Auburn
state: California
city: Bakersfield
country: United States
facility: AIS Cancer Center at Adventist Health Bakersfield
state: California
city: Beverly Hills
country: United States
facility: Beverly Hills Cancer Center
state: California
city: Burbank
country: United States
facility: Providence Health and Services Southern California
state: California
city: Chico
country: United States
facility: Enloe Regional Cancer Center
state: California
city: Concord
country: United States
facility: John Muir Clinical Research Center
state: California
city: Concord
country: United States
facility: John Muir Medical Center, Concord Campus
state: California
city: Concord
country: United States
facility: Mount Diablo Solano Oncology Group
state: California
city: Gilroy
country: United States
facility: Global Cancer Research Institute, Inc.
state: California
city: Laguna Hills
country: United States
facility: Breastlink Medical Group, Inc.
state: California
city: Newport Beach
country: United States
facility: Breastlink Medical Group, Inc.
state: California
city: Orange
country: United States
facility: Breastlink Medical Group, Inc.
state: California
city: Petaluma
country: United States
facility: St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare
state: California
city: Pleasant Hill
country: United States
facility: Diablo Valley Oncology Hematology Medical Group
state: California
city: Pleasant Hill
country: United States
facility: Epic Care
state: California
city: Roseville
country: United States
facility: Sutter Roseville Medical Center
state: California
city: Sacramento
country: United States
facility: Sutter Institute for Medical Research
state: California
city: Saint Helena
country: United States
facility: St. Helena Hospital
state: California
city: Salinas
country: United States
facility: Salinas Valley Medical Clinic Cancer Care
state: California
city: Salinas
country: United States
facility: Salinas Valley Memorial Healthcare System
state: California
city: San Jose
country: United States
facility: Santa Clara Valley Medical Center
state: California
city: Santa Ana
country: United States
facility: Cancer Research Collaboration/Breastlink Medical Group, Inc.
state: California
city: Santa Barbara
country: United States
facility: Ridley Tree Cancer Center
state: California
city: Santa Barbara
country: United States
facility: SANSUM Clinic
state: California
city: Santa Rosa
country: United States
facility: St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare
state: California
city: Solvang
country: United States
facility: Sansum Clinic
state: California
city: Stockton
country: United States
facility: St. Joseph's Medical Center
state: California
city: Stockton
country: United States
facility: Stockton Hematology Oncology Medical Group
state: California
city: Vacaville
country: United States
facility: Cancer Treatment Center of Vacaville
state: California
city: Vallejo
country: United States
facility: Solano Hematology Oncology
state: California
city: Walnut Creek
country: United States
facility: Contra Costa Oncology
state: California
city: Walnut Creek
country: United States
facility: John Muir Medical Center, Walnut Creek Camous
state: California
city: Aurora
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Boulder
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Colorado Springs
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Denver
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Denver
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Grand Junction
country: United States
facility: Colorado West Healthcare System, dba Community Hospital
state: Colorado
city: Grand Junction
country: United States
facility: Colorado West Healthcare System, dba Grand Valley Oncology
state: Colorado
city: Lakewood
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Littleton
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Lone Tree
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Longmont
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Parker
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Pueblo
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Thornton
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Danbury
country: United States
facility: Western Connecticut Health Network
state: Connecticut
city: New Milford
country: United States
facility: Western Connecticut Health Network
state: Connecticut
city: Norwalk
country: United States
facility: Western Connecticut Health Network
state: Connecticut
city: Washington
country: United States
facility: MedStar Washington Hospital Center
state: District of Columbia
city: Boca Raton
country: United States
facility: Florida Cancer Research Institute
state: Florida
city: Boca Raton
country: United States
facility: Boca Raton Regional Hospital/Lynn Cancer Institute
state: Florida
city: Fleming Island
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Fort Lauderdale
country: United States
facility: Southeast Florida Hematology-Oncology Group, PA
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Jacksonville
country: United States
facility: University of Florida Health
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists LLC
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Lakeland
country: United States
facility: Watson Clinic
state: Florida
city: Miami
country: United States
facility: Baptist Health Medical Group Oncology, LLC
state: Florida
city: Miami
country: United States
facility: Baptist Health Miami Cancer Institute
state: Florida
city: Miami
country: United States
facility: Miami Cancer Institute at Baptist Health, Inc.
state: Florida
city: Middleburg
country: United States
facility: Cancer Specialists of North Florida - St. Vincent's Clay
state: Florida
city: Pembroke
country: United States
facility: Millennium Oncology Research Clinic/Hematology and Oncology Private Practice
state: Florida
city: Plantation
country: United States
facility: Baptist Health Miami Cancer Institute
state: Florida
city: Plantation
country: United States
facility: Florida Cancer Research Institute
state: Florida
city: Saint Augustine
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Sunrise
country: United States
facility: Baptist Health Urgent Care Sawgrass
state: Florida
city: Austell
country: United States
facility: Northwest Georgia Oncology Centers, PC
state: Georgia
city: Carrollton
country: United States
facility: Northwest Georgia Oncology Centers, PC
state: Georgia
city: Cartersville
country: United States
facility: Northwest Georgia Oncology Centers, PC
state: Georgia
city: Douglasville
country: United States
facility: Northwest Georgia Oncology Centers, PC
state: Georgia
city: Duluth
country: United States
facility: Gwinnett Hospital System, Inc. The Center for Cancer Care
state: Georgia
city: Duluth
country: United States
facility: Gwinnett Hospital System, Inc.
state: Georgia
city: Lawrenceville
country: United States
facility: Gwinnett Hospital System Inc.
state: Georgia
city: Lawrenceville
country: United States
facility: Gwinnett Hospital System, Inc. The Center for Cancer Care
state: Georgia
city: Marietta
country: United States
facility: Northwest Georgia Oncology Centers, PC
state: Georgia
city: Roswell
country: United States
facility: Northwest Georgia Oncology Centers, PC
state: Georgia
city: Savannah
country: United States
facility: Candler Medical Oncology Practice (CMOP)/Summit Cancer Care
state: Georgia
city: Savannah
country: United States
facility: Summit Cancer Care Research
state: Georgia
city: Savannah
country: United States
facility: Candler Medical Oncology Practice (CMOP)
state: Georgia
city: Snellville
country: United States
facility: Gwinnett Hospital System, Inc. The Center for Cancer Care
state: Georgia
city: Arlington Heights
country: United States
facility: Illinois Cancer Specialists
state: Illinois
city: Bourbonnais
country: United States
facility: Presence St. Mary's Cancer Center
state: Illinois
city: Chicago
country: United States
facility: Presence Saint Joseph Hospital
state: Illinois
city: Crystal Lake
country: United States
facility: North Shore Oncology Hematology Associates
state: Illinois
city: Crystal Lake
country: United States
facility: North Shore Oncology-Hematology Associates
state: Illinois
city: Evanston
country: United States
facility: Presence Infusion Care - Evanston
state: Illinois
city: Joliet
country: United States
facility: Joliet Oncology-Hematology Associates, LTD
state: Illinois
city: Libertyville
country: United States
facility: Advocate Condell Medical Center
state: Illinois
city: Libertyville
country: United States
facility: North Shore Oncology-Hematology Associates
state: Illinois
city: Morris
country: United States
facility: Joliet Oncology-Hematology Associates, LTD
state: Illinois
city: New Lenox
country: United States
facility: Joliet Oncology-Hematology Associates, LTD
state: Illinois
city: Normal
country: United States
facility: Mid Illinois Hematology And Oncology Associates, Limited
state: Illinois
city: Quincy
country: United States
facility: Quincy Medical Group
state: Illinois
city: Skokie
country: United States
facility: Orchard Healthcare Research Inc.
state: Illinois
city: Skokie
country: United States
facility: Presence Infusion Care - Skokie
state: Illinois
city: Newburgh
country: United States
facility: Oncology Hematology Associates of Southwest Indiana
state: Indiana
city: Ames
country: United States
facility: McFarland Clinic, P.C.
state: Iowa
city: Cedar Rapids
country: United States
facility: Oncology Associates at Mercy Medical Center
state: Iowa
city: Topeka
country: United States
facility: Stormont Vail Regional Health Center
state: Kansas
city: Topeka
country: United States
facility: Stormont Vail Cotton O'Neill Cancer Center
state: Kansas
city: Westwood
country: United States
facility: University of Kansas Cancer Center
state: Kansas
city: Baton Rouge
country: United States
facility: Our Lady of the Lake Regional Medical Center
state: Louisiana
city: Baton Rouge
country: United States
facility: Mary Bird Perkins Cancer Center
state: Louisiana
city: Baton Rouge
country: United States
facility: Our Lady of the Lake Physician Group, Louisiana Hematology Oncology Associates
state: Louisiana
city: Baton Rouge
country: United States
facility: Our Lady of the Lake Regional Medical Center, Oncology 6
state: Louisiana
city: Covington
country: United States
facility: Pontchartrain Cancer Center
state: Louisiana
city: Hammond
country: United States
facility: Pontchartrain Cancer Center
state: Louisiana
city: Marrero
country: United States
facility: Cancer Center at West Jefferson Medical Center, New Orleans Physician Services, Inc.
state: Louisiana
city: Marrero
country: United States
facility: Crescent City Research Consortium, LLC
state: Louisiana
city: Metairie
country: United States
facility: East Jefferson General Hospital
state: Louisiana
city: New Orleans
country: United States
facility: Touro Infirmary
state: Louisiana
city: Baltimore
country: United States
facility: Mercy Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Greater Baltimore Medical Center
state: Maryland
city: Bethesda
country: United States
facility: Maryland Oncology and Hematology, PA
state: Maryland
city: Chevy Chase
country: United States
facility: The Office of Frederick P. Smith, MD
state: Maryland
city: Clinton
country: United States
facility: Maryland Oncology Hematology, P.A.
state: Maryland
city: Columbia
country: United States
facility: Maryland Oncology Hematology, P.A.
state: Maryland
city: Frederick
country: United States
facility: Maryland Oncology Hematology, P.A.
state: Maryland
city: Haggerstown
country: United States
facility: Antietam Oncology and Hematology Group, PC
state: Maryland
city: Rockville
country: United States
facility: Maryland Oncology Hematology, P.A.
state: Maryland
city: Silver Spring
country: United States
facility: Maryland Oncology Hematology, P.A.
state: Maryland
city: Silver Spring
country: United States
facility: Maryland Oncology Hematology, P.A.
state: Maryland
city: Towson
country: United States
facility: University of Maryland St. Joseph Medical Center
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Newton
country: United States
facility: New England Hematology Oncology/Massachusetts General Cancer Center at Newton Wellesley Hospital
state: Massachusetts
city: Worcester
country: United States
facility: University of Massachusetts Memorial Medical Center
state: Massachusetts
city: Grosse Pointe Woods
country: United States
facility: Great Lakes Cancer Management
state: Michigan
city: Traverse City
country: United States
facility: Munson Medical Center
state: Michigan
city: Warren
country: United States
facility: Great Lakes Cancer Management
state: Michigan
city: Burnsville
country: United States
facility: Fairview Ridges Hospital
state: Minnesota
city: Coon Rapids
country: United States
facility: Minnesota Oncology Hematology, PA
state: Minnesota
city: Edina
country: United States
facility: Fairview Southdale Hospital
state: Minnesota
city: Edina
country: United States
facility: Fairview Southdale Medical Oncology Clinic
state: Minnesota
city: Maple Grove
country: United States
facility: University of Minnesota Health Maple Grove Clinics
state: Minnesota
city: Minneapolis
country: United States
facility: Minnesota Oncology Hematology, PA
state: Minnesota
city: Saint Louis Park
country: United States
facility: Metro-Minnesota Community Oncology Research Consortium
state: Minnesota
city: Saint Louis Park
country: United States
facility: Health Partners Institute
state: Minnesota
city: Saint Louis Park
country: United States
facility: Park Nicollet Frauenshuh Cancer Center
state: Minnesota
city: Saint Paul
country: United States
facility: Regions Hospital Cancer Care Center
state: Minnesota
city: Saint Paul
country: United States
facility: Regions Hospital
state: Minnesota
city: Saint Paul
country: United States
facility: Minnesota Oncology Hematology, PA
state: Minnesota
city: Stillwater
country: United States
facility: Lakeview Hospital
state: Minnesota
city: Willmar
country: United States
facility: Rice Memorial Hospital
state: Minnesota
city: Woodbury
country: United States
facility: Minnesota Oncology Hematology, PA
state: Minnesota
city: Tupelo
country: United States
facility: North Mississippi Medical Center, Inc., Hematology and Oncology Research
state: Mississippi
city: Ballwin
country: United States
facility: Mercy Clinic St. Louis Cancer and Breast Institute
state: Missouri
city: Bridgeton
country: United States
facility: St. Louis Cancer Care, LLP
state: Missouri
city: Chesterfield
country: United States
facility: St. Louis Cancer Care, LLP
state: Missouri
city: Columbia
country: United States
facility: Boone Hospital Center
state: Missouri
city: Columbia
country: United States
facility: Missouri Cancer Associates
state: Missouri
city: Kansas City
country: United States
facility: St. Luke's Cancer Institute - East
state: Missouri
city: Kansas City
country: United States
facility: St. Luke's Cancer Institute
state: Missouri
city: Liberty
country: United States
facility: St. Luke's Cancer Institute - Liberty
state: Missouri
city: North Kansas City
country: United States
facility: University of Kansas Cancer Center
state: Missouri
city: Saint Joseph
country: United States
facility: Heartland Regional Medical Center/dba Cancer Care St. Joseph Mosaic Life Care
state: Missouri
city: Saint Louis
country: United States
facility: Mercy Clinic St. Louis Cancer and Breast Institute
state: Missouri
city: Saint Louis
country: United States
facility: SSM Health St. Louis University Hospital
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis University Cancer Center
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis Cancer Care, LLP
state: Missouri
city: Saint Louis
country: United States
facility: Mercy Hospital St. Louis
state: Missouri
city: Saint Louis
country: United States
facility: Mercy Research - Mercy Heart Hospital St. Louis
state: Missouri
city: Lincoln
country: United States
facility: Nebraska Hematology/Oncology, PC
state: Nebraska
city: Portsmouth
country: United States
facility: Portsmouth Regional Hospital
state: New Hampshire
city: Hackensack
country: United States
facility: Hackensack University Medical Center, John Theurer Cancer Center
state: New Jersey
city: Paramus
country: United States
facility: The Valley Hospital
state: New Jersey
city: Phillipsburg
country: United States
facility: St. Luke's University Heatlh Network - Warren Hospital
state: New Jersey
city: Brewster
country: United States
facility: CareMount Medical
state: New York
city: East Setauket
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: Mount Kisco
country: United States
facility: CareMount Medical
state: New York
city: Mount Kisco
country: United States
facility: Northern Westchester Hospital
state: New York
city: Patchogue
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: Port Jefferson Station
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: Riverhead
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: Smithtown
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: White Plains
country: United States
facility: White Plains Hospital
state: New York
city: Asheville
country: United States
facility: Asheville Hematology and Oncology
state: North Carolina
city: Clayton
country: United States
facility: Johnston Health Services Corporation - Clayton
state: North Carolina
city: Clyde
country: United States
facility: Haywood Infusion Center
state: North Carolina
city: Fayetteville
country: United States
facility: Cape Fear Valley Health System
state: North Carolina
city: Fayetteville
country: United States
facility: Cape Fear Valley Health System
state: North Carolina
city: Greenville
country: United States
facility: East Carolina University Brody School of Medicine
state: North Carolina
city: Hendersonville
country: United States
facility: Advent Health - Hendersonville
state: North Carolina
city: Henderson
country: United States
facility: DLP Maria Parham Medical Center
state: North Carolina
city: High Point
country: United States
facility: University of North Carolina Regional Physicians Hematology Oncology
state: North Carolina
city: Kernersville
country: United States
facility: Novant Health Oncology Specialists
state: North Carolina
city: Laurinburg
country: United States
facility: Duke Cancer Network
state: North Carolina
city: Lumberton
country: United States
facility: Southeastern Regional Medical Center
state: North Carolina
city: Mount Airy
country: United States
facility: Novant Health Oncology Specialists
state: North Carolina
city: North Wilkesboro
country: United States
facility: Novant Health Oncology Specialists
state: North Carolina
city: Smithfield
country: United States
facility: Johnston Health Services Corporation - Smithfield
state: North Carolina
city: Statesville
country: United States
facility: Novant Health Oncology Specialists
state: North Carolina
city: Thomasville
country: United States
facility: Novant Health Oncology Specialists
state: North Carolina
city: Winston-Salem
country: United States
facility: Novant Health Oncology Specialists
state: North Carolina
city: Canton
country: United States
facility: Hematology Oncology Associates, Inc.
state: Ohio
city: Canton
country: United States
facility: Mercy Medical Center
state: Ohio
city: Columbus
country: United States
facility: Mid Ohio Oncology/Hematology, Inc. dba The Mark H. Zangmeister Center
state: Ohio
city: Dover
country: United States
facility: Tri-County Hematology and Oncology Associates, Inc.
state: Ohio
city: Massilon
country: United States
facility: Tri-County Hematology and Oncology Associates, Inc.
state: Ohio
city: Perrysburg
country: United States
facility: Mercy Health Perrysburg Cancer Center
state: Ohio
city: Toledo
country: United States
facility: Mercy Health St. Vincent Medical Center
state: Ohio
city: Toledo
country: United States
facility: Mercy Health Cancer Center
state: Ohio
city: Warren
country: United States
facility: Mercy Health Youngstown dba St Joseph Warren Hospital
state: Ohio
city: Youngstown
country: United States
facility: Mercy Health Youngstown dba St. Elizabeth Youngstown Hospital
state: Ohio
city: Eugene
country: United States
facility: Willamette Valley Cancer Institute and Research Center
state: Oregon
city: Portland
country: United States
facility: Northwest Cancer Specialists, PC
state: Oregon
city: Portland
country: United States
facility: Northwest Cancer Specialists, PC
state: Oregon
city: Springfield
country: United States
facility: Willamette Valley Cancer Institute and Research Center
state: Oregon
city: Allentown
country: United States
facility: St. Luke's University Health Network - Sacred Heart Hospital
state: Pennsylvania
city: Allentown
country: United States
facility: St. Luke's Hospital - Allentown Campus
state: Pennsylvania
city: Bethlehem
country: United States
facility: St. Luke's Hematology Oncology Specialists
state: Pennsylvania
city: Bethlehem
country: United States
facility: St. Luke's University Heatlh Network
state: Pennsylvania
city: Bethlehem
country: United States
facility: St. Luke's Hematology Oncology Specialists
state: Pennsylvania
city: Easton
country: United States
facility: St. Luke's University Heatlh Network
state: Pennsylvania
city: Harrisburg
country: United States
facility: Pinnacle Health Cancer Center
state: Pennsylvania
city: Harrisburg
country: United States
facility: Pinnacle Health Cancer Institute
state: Pennsylvania
city: Lancaster
country: United States
facility: Lancaster Cancer Center
state: Pennsylvania
city: Mechanicsburg
country: United States
facility: Ortenzio Cancer Center at Pinnacle Health
state: Pennsylvania
city: Charleston
country: United States
facility: Charleston Cancer Center
state: South Carolina
city: Easley
country: United States
facility: Greenville Health System
state: South Carolina
city: Georgetown
country: United States
facility: Tidelands Waccamaw Oncology/Georgrtown Hospital System
state: South Carolina
city: Greenville
country: United States
facility: Greenville Health System
state: South Carolina
city: Greenville
country: United States
facility: Greenville Health System
state: South Carolina
city: Greer
country: United States
facility: Greenville Health System
state: South Carolina
city: Lancaster
country: United States
facility: Carolina Blood and Cancer Care Associates, PA
state: South Carolina
city: Murrells Inlet
country: United States
facility: Tidelands Waccamaw Oncology/Georgrtown Hospital System
state: South Carolina
city: Myrtle Beach
country: United States
facility: Tidelands Waccamaw Oncology/Georgrtown Hospital System
state: South Carolina
city: Rock Hill
country: United States
facility: Carolina Blood and Cancer Care Associates, PA
state: South Carolina
city: Seneca
country: United States
facility: Greenville Health System
state: South Carolina
city: Spartanburg
country: United States
facility: Spartanburg Regional Medical Center
state: South Carolina
city: Spartanburg
country: United States
facility: Greenville Health System
state: South Carolina
city: Sumter
country: United States
facility: M. Francisco Gonzalez, MD, PA
state: South Carolina
city: Bristol
country: United States
facility: Wellmont Bristol Regional Medical Center
state: Tennessee
city: Bristol
country: United States
facility: Wellmont Medical Associates Oncology and Hematology
state: Tennessee
city: Chattanooga
country: United States
facility: University of Tennessee/Erlanger Oncology and Hematology
state: Tennessee
city: Johnson City
country: United States
facility: Wellmont Medical Associates Oncology and Hematology
state: Tennessee
city: Kingsport
country: United States
facility: Wellmont Cancer Institute
state: Tennessee
city: Kingsport
country: United States
facility: Wellmont Holston Valley Medical Center
state: Tennessee
city: Allen
country: United States
facility: Texas Oncology -Allen
state: Texas
city: Dallas
country: United States
facility: Texas Oncology
state: Texas
city: Denton
country: United States
facility: Texas Oncology-Denton South
state: Texas
city: El Paso
country: United States
facility: Texas Oncology-El Paso Cancer Treatment Center
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology - Fort Worth Cancer Center
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology - Southwest Fort Worth
state: Texas
city: Houston
country: United States
facility: Texas Oncology
state: Texas
city: Houston
country: United States
facility: MD Anderson Cancer Center
state: Texas
city: Lubbock
country: United States
facility: University Medical Center Health System, Southwest Cancer Center
state: Texas
city: McAllen
country: United States
facility: Texas Oncology
state: Texas
city: McKinney
country: United States
facility: Texas Oncology - McKinney
state: Texas
city: Mesquite
country: United States
facility: Texas Oncology
state: Texas
city: Paris
country: United States
facility: Texas Oncology-Paris
state: Texas
city: Plano
country: United States
facility: Texas Oncology
state: Texas
city: San Antonio
country: United States
facility: Texas Oncology-San Antonio Downtown
state: Texas
city: San Antonio
country: United States
facility: Texas Oncology
state: Texas
city: San Antonio
country: United States
facility: Texas Oncology-San Antonio Stone Oak
state: Texas
city: Tyler
country: United States
facility: Texas Oncology
state: Texas
city: Arlington
country: United States
facility: Virginia Cancer Specialists
state: Virginia
city: Bristol
country: United States
facility: Wellmont Medical Associates Oncology and Hematology
state: Virginia
city: Chesapeake
country: United States
facility: Cancer Specialists of Tidewater/Riverside Cancer Infusion Center
state: Virginia
city: Fairfax
country: United States
facility: Virginia Cancer Specialists
state: Virginia
city: Fishersville
country: United States
facility: Augusta Health Cancer Center
state: Virginia
city: Gainesville
country: United States
facility: Virginia Cancer Specialists
state: Virginia
city: Gloucester
country: United States
facility: Peninsula Cancer Institute/Riverside Cancer Infusion Center
state: Virginia
city: Leesburg
country: United States
facility: Virginia Cancer Specialists
state: Virginia
city: Mechanicsville
country: United States
facility: Bon Secours Memorial Regional Medical Center, Inc.
state: Virginia
city: Mechanicsville
country: United States
facility: Bon Secours Richmond Community Hospital dba Oncology Associates at Memorial Regional Medical Center
state: Virginia
city: Midlothian
country: United States
facility: Bon Secours Cancer Institute @ St. Francis Medical Center
state: Virginia
city: Midlothian
country: United States
facility: Bon Secours Richmond Community Hospital dba Oncology Associates at St. Francis Medical Center
state: Virginia
city: Midlothian
country: United States
facility: Bon Secours St. Francis Medical Center, Inc.
state: Virginia
city: Nassawadox
country: United States
facility: Riverside Shore Cancer Center
state: Virginia
city: Newport News
country: United States
facility: Peninsula Cancer Institute/Riverside Cancer Infusion Center
state: Virginia
city: Norton
country: United States
facility: Southwest Virginia Regional Cancer Center
state: Virginia
city: Portsmouth
country: United States
facility: Delta Hematology/Oncology Associates
state: Virginia
city: Richmond
country: United States
facility: Bon Secours Richmond Community Hospital dba Oncologists Associates at St. Mary's Hospital
state: Virginia
city: Richmond
country: United States
facility: Bon Secours St. Mary's Hospital, Inc.
state: Virginia
city: Suffolk
country: United States
facility: Cancer Specialists of Tidewater/Riverside Cancer Infusion Center
state: Virginia
city: Virginia Beach
country: United States
facility: Cancer Specialists of Tidewater/Riverside Cancer Infusion Center
state: Virginia
city: Williamsburg
country: United States
facility: Peninsula Cancer Institute/Riverside Cancer Infusion Center
state: Virginia
city: Seattle
country: United States
facility: Seattle Cancer Care Alliance
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists, PC
state: Washington
city: Bridgeport
country: United States
facility: West Virginia University Medicine - United Hospital Center
state: West Virginia
city: Huntington
country: United States
facility: Huntington Internal Medicine Group
state: West Virginia
city: Huntington
country: United States
facility: St. Mary's Medical Center
state: West Virginia
city: Morgantown
country: United States
facility: West Virginia University, Mary Babb Randolph Cancer Center
state: West Virginia
city: Parkersburg
country: United States
facility: Camden Clark Medical Center
state: West Virginia
city: Burnaby
country: Canada
facility: Burnaby Hospital Cancer Centre
state: British Columbia
city: Mississauga
country: Canada
facility: Trillium Health Partners
state: Ontario
city: Toronto
country: Canada
facility: St. Michael's Hospital
state: Ontario
city: Chicoutimi
country: Canada
facility: Integrated University Center for Health and Social Services (CIUSSS) of Saguenay-Lac Saint Jean
state: Quebec
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References:
citation: Tripathy D, Blum JL, Rocque GB, Bardia A, Karuturi MS, Cappelleri JC, Liu Y, Zhang Z, Davis KL, Wang Y. POLARIS: a prospective, multicenter, noninterventional study assessing palbociclib in hormone receptor-positive advanced breast cancer. Future Oncol. 2020 Nov;16(31):2475-2485. doi: 10.2217/fon-2020-0573. Epub 2020 Aug 13.