louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03788421: Comparison Between 2 Techniques for Bilateral Salpingectomy
Official title: Comparison Between 2 Techniques for Bilateral Salpingectomy During Cesarean Section
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sterility, Female
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2018-12-27
Enrollment: 51
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A comparison between 2 techniques for bilateral salpingectomy during cesarean section.

Primary outcomes are total operative time and bilateral completion of the randomized procedure. Secondary outcomes included surgical complications and post operation complications.

Detailed description: Ovarian cancer is the most lethal gynecologic malignancy. Major contributors to this high mortality are the lack of effective screening strategies, diagnosis at advanced stage of presentation as well as the high risk of recurrence. In the last years the Gynecologic Associations worldwide have recommended that total salpingectomy be considered for potential ovarian cancer risk reduction in benign gynecologic surgeries after completion of childbearing.

However, the data are limit regarding the Preferred surgical technique during cesarean section.

In this randomized controled trial the investigators will compare between various techniques for bilateral salpingectomy during cesarean section.

Primary outcomes are total operative time and bilateral completion of the randomized procedure. Secondary outcomes included surgical complications and post operation complications.

Eligibility criteria: Inclusion Criteria:

* Participants undergoing elective Cesarean Section and are interested and have signed informed consent regarding bilateral salpingectomy.

Exclusion Criteria:

* Inability to give informed consent.
* Preterm delivery (\< 37 weeks' gestation).
* Fetal demise.
* Prenatal diagnosis of fetal or placental abnormalities.
* Previous tubal surgery.
* The use of anticoagulants.
* Associated immunosuppressive conditions.

Primary outcomes:
measure: Total salpingectomy time.
timeFrame: Up to 1 week from recruitment
Secondary outcomes:
measure: Bleeding during salpingectomy
timeFrame: Up to 4 hours from the beginning of the procedure
measure: Bleeding during cesarean section
timeFrame: Up to 4 hours from the beginning of the procedure
measure: Hemoglobin level
timeFrame: Up to 5 days from surgery
measure: Blood transfusion rate
timeFrame: Up to 5 days from surgery
measure: Postoperative stay
timeFrame: Up to 2 weeks from surgery
measure: Visual analogue score
timeFrame: Up to 2 weeks from surgery
measure: Wound complications
timeFrame: Up to 2 weeks from surgery
measure: Need for opioids
timeFrame: Up to 2 weeks from surgery
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Rambam health care campus
Study officials:
affiliation: Rambam healthcare campus
name: Yaniv Zipori, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06674421: Reliability of GYCO in Basketball Players
Official title: Reliability of GYKO Inertial Sensor System in the Assessment of Jumping and Postural Stability Parameters in Adolescent Basketball Players
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Healthy
Keywords: athletes
validity and reliability
jump
postural stability
Lead sponsor: Sakarya University
Sponsor class: OTHER
First posted: 2024-11-05
Enrollment: 42
Sex: ALL
Minimum age (years): 10
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants will be adolescent athletes attending the basketball course at Alaağaç Sports Club.

Brief summary: The aim of this study was to evaluate the reliability of the GYKO, which enables the assessment of jump and postural stability parameters of athletes, in adolescent basketball players.

Detailed description: GYKO is a device used to evaluate joint function, muscle strength, jumping and postural stability parameters during rehabilitation of a specific region of the musculoskeletal system. The aim of this study was to evaluate the reliability of the GYKO, which enables the assessment of jump and postural stability parameters of athletes, in adolescent basketball players.

The research will be conducted at Sakarya University of Applied Sciences Physiotherapy and Rehabilitation Application and Research Centre. The participants will consist of adolescent athletes attending the basketball course at Alaağaç Sports Club.

Eligibility criteria: Inclusion Criteria:

* Being between the ages of 10-19 years old
* Being playing basketball.

Exclusion Criteria:

* Having musculoskeletal system, rheumatological, cardiovascular etc. diseases

Primary outcomes:
measure: Counter Movement Jump
timeFrame: The evaluation will be conducted at the baseline and 1 week after the first evaluation.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Sakarya University of Applied Sciences
name: EMEL TAŞVURAN HORATA, Assoc. Prof.
role: PRINCIPAL_INVESTIGATOR
affiliation: Sakarya University of Applied Sciences
name: Oğuzhan Bahadır Demir, PhD
role: STUDY_CHAIR
affiliation: Sakarya University of Applied Sciences
name: Birgül DINGIRDAN GÜLTEKİNLER, MSc
role: STUDY_CHAIR
References:
Clinical trial NCT05089721: Questionnaire for Obstetricians and Anesthesiologist
Official title: Questionnaire for Evaluation of Uterotonic Usage Habits of Obstetricians and Anesthesiologist
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Uterine Bleeding
Atony, Uterine
Cesarean Section Complications
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2021-10-22
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Through national obstetrics and anesthesiologist associations, the survey will be sent to the participant's e-mail addresses. Those who answer the questionnaire will be included in the study.

Brief summary: The research was planned as a face-to-face survey evaluation. The questionnaire will be applied to obstetricians and anesthesiologists working in public and private hospitals. The universe of the research will be selected by simple random sampling method, and the total number of people who will participate is planned to be 200, approximately 100 from each of the two branches. Our survey consists of 5 parts structurally. Demographic data, rate of cesarean section and postpartum hemorrhage, uterotonic agent preferences in low/high risk cesarean section surgeries, the preference for second-line uterotonic agents, and the dose preferences of uterotonic agents.


Eligibility criteria: Inclusion Criteria: obstetricians and anesthesiologists who want to participate in the survey

Exclusion Criteria: the ones who do not want to participate

-

Primary outcomes:
measure: Uterotonic usage habits in postpartum hemorrhage
timeFrame: 3 months
Secondary outcomes:
measure: Uterotonic usage habits in elective cesearean section
timeFrame: 3 months
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazi University School of Medicine
Study officials:
References:
Clinical trial NCT01427621: Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery
Official title: Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Heart Valve Diseases
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2011-09-01
Enrollment: 54
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Pulmonary dysfunction after cardiac surgery with CPB remains to be a problem complicating the postoperative course of the patients. The investigators hypothesized that RIPCcom, combined intervention of remote ischemic preconditioning and remote ischemic postconditioning, would confer beneficial influence on inflammatory response and resultant postoperative pulmonary dysfunction after CPB in patients undergoing complex valvular heart surgery who are at increased risk of postoperative pulmonary dysfunction.The aim of this study was to evaluate the lung-protective effect of combined remote ischemic pre- and post-conditioning in patients undergoing complex valvular heart surgery.


Eligibility criteria: Inclusion Criteria:

* patients undergoing valvular heart surgery.
* Age: 20\~80.

Exclusion Criteria:

* Emergency operation.
* patients with peripheral vascular disease.
* Patients with a known history or clinical evidence of chronic obstructive pulmonary disease.
* Patients with hepatic or renal dysfunction
* Patients with acute myocardial infarction within 1 week before surgery

Primary outcomes:
measure: Comparison of postoperative PaO2/FiO2
timeFrame: at 10 minutes after anesthetic induction
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine
name: Young-Lan Kwak, MD, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kim JC, Shim JK, Lee S, Yoo YC, Yang SY, Kwak YL. Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery. Chest. 2012 Aug;142(2):467-475. doi: 10.1378/chest.11-2246.
Clinical trial NCT01594021: Efficacy of Preemptive Volume Loading to Prevent Arterial Hypotension During Induction of General Anesthesia
Official title: Efficacy of Preemptive Volume Loading to Prevent Arterial Hypotension During Induction of General Anesthesia
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Anesthesia
Keywords: propofol
anesthesia, induction
hypotension
cardiac output
Lead sponsor: Hopital Foch
Sponsor class: OTHER
First posted: 2012-05-08
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Induction of general anesthesia induces frequently arterial hypotension. The short term goal of this study is to evaluate if preemptive volume loading prevents such complication.

Detailed description: This is a randomized, prospective study which will include a total of 200 patients who are scheduled to undergo elective surgery. The research participants will be randomly assigned to

* a control group that will receive a low preemptive volume loading (50 mL of gelatin),
* a protocol group that will receive a high preemptive volume loading (500 mL of gelatin).

Volume loading is preceded by the measurement of stroke volume and cardiac output before and after a passive leg elevation test and followed by a standardized anesthetic protocol.

Eligibility criteria: Inclusion Criteria:

* Adult patients undergoing elective surgery.

Exclusion Criteria:

* Difficult peripheral venous access
* Allergy to gelatin
* Symptomatic cardiac disease, rhythm trouble, pace-maker, aortic valvular disease, aortic disease
* Morbid obesity, low BMI,
* hypovolemia,
* Raynaud syndrome or scleroderma,
* Contra-indication to propofol, remifentanil or to the use of Bispectral Index,
* Hematocrit \< 20%.

Primary outcomes:
measure: Hypotension
timeFrame: 30 minutes
Secondary outcomes:
measure: hemodynamic effect of leg passive elevation test
timeFrame: 30 minutes
measure: hemodynamic effect of volume loading
timeFrame: 30 minutes
measure: heart rate monitoring
timeFrame: 30 minutes
measure: propofol dose when bispectral index is 50
timeFrame: 30 minutes
measure: propofol site effect concentration when bispectral index is 50
timeFrame: 30 minutes
measure: arterial pressure monitoring
timeFrame: 30 minutes
Other outcomes:
Locations:
city: Suresnes
country: France
facility: Hopital Foch
Study officials:
affiliation: Hopital Foch
name: Morgan Le Guen
role: PRINCIPAL_INVESTIGATOR
affiliation: Hopital Foch
name: Marc Fischler
role: STUDY_DIRECTOR
References:
Clinical trial NCT06160921: Prognostic Model of Hypertension
Official title: Prognostic Model of Hypertension
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Hypertension
Lead sponsor: Xinjiang Medical University
Sponsor class: OTHER
First posted: 2023-12-07
Enrollment: 50000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: A patient diagnosed with primary hypertension who was admitted to the First Affiliated Hospital of Xinjiang Medical University

Brief summary: The aim of this study was to establish a registration and monitoring system for hypertension in Xinjiang from 2020 to 2030 to obtain real information about patient basic information, patient characteristics, diagnostic test patterns, treatment options, and hospitalization outcomes (including mortality). Treatment complications, hospitalization costs, and end-of-life events (death, major adverse cardiac events, mild adverse cardiovascular events) in patients with hypertension in Xinjiang; and scientific prevention strategies aimed at effectively preventing the onset of hypertension; Guidelines in clinical practice recommend, analyze and develop effective treatment strategies to optimize management and outcomes for patients with hypertension; and create cost-effective assessment systems.

Detailed description: The aim of the study is to establish a platform for monitoring, clinical research and translational medicine in Xinjiang, which aims to provide a basis for future quality improvement and research, and to promote efforts to improve the prognosis of patients with hypertension, and to translate research into improved care for patients, thereby reducing Morbidity and mortality associated with hypertension.

Eligibility criteria: Inclusion Criteria:

* A patient diagnosed with primary hypertension who was admitted to the First Affiliated Hospital of Xinjiang Medical University

Exclusion Criteria:

* Patients with secondary hypertension, patients with liver and kidney dysfunction,
* patients with mental disorders, and patients who are unwilling to participate in this trial

Primary outcomes:
measure: Resistant hypertension
timeFrame: 10 years of follow-up Resistant hypertension occurred during this period
measure: Death (all-cause mortality, mortality from hypertension complications)
timeFrame: 10 years of follow-up deaths occurred during this period
Secondary outcomes:
measure: Major adverse cardiovascular events
timeFrame: 10 years of follow-up deaths occurred during this period
Other outcomes:
Locations:
city: Ürümqi
country: China
facility: The First Affiliated Hospital of Xinjiang Medicial University
state: Xinjiang
Study officials:
References:
Clinical trial NCT05271721: Trans-foraminal Lumbar Epidural Injection of Dexmedetomidine Against Magnesium Sulfate When Combined With Dexamethasone in Uni-lateral Lower Limb Radicular Pain. Multi-centeric Comparative Study
Official title: Trans-foraminal Lumbar Epidural Injection of Dexmedetomidine Against Magnesium Sulfate When Combined With Dexamethasone in Uni-lateral Lower Limb Radicular Pain. Multi-centeric Comparative Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Pain
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2022-03-09
Enrollment: 90
Sex: ALL
Minimum age (years): 25
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Transforaminal injection of chronic radicular lower limb injection by either dexmedetomdine or magnesuim sulfate


Eligibility criteria: Inclusion Criteria:

* Age group. 25-75ys old
* Both sex.
* Lumber disc protrusion at one or two segments on MRI.
* Chronic lumbar radiculer pain for more than 6 weeks refractory to
* medical treatment for at least 4 weeks. .
* Positve leg rising test at 30-70 degrees.

Exclusion Criteria:

* Diabetic candidates ( type Ior II).
* Patient refusal.
* MRI with disc sequestration.
* Neurological examination revealed foot drop, neuropathic ulcers
* Myelopathic or scoliotic patients, .
* Coagulopathic patients ( cirrhotic patients, on anti-coagulation )

Primary outcomes:
measure: pain score
timeFrame: up to 6 months post-injection
Secondary outcomes:
measure: functional disability
timeFrame: up to 6 months post injection
measure: acute complications
timeFrame: 6 hours post-injection
Other outcomes:
Locations:
city: Minia
country: Egypt
facility: Minia University
state: Minia University Hospital
Study officials:
References:
Clinical trial NCT01679821: Prevalence of Signs and Symptoms of TMD in Patients Wearing Double Complete Dentures, RPD and in Dentistry Students.
Official title: Prevalence of Signs and Symptoms of Temporomandibular Disorders (TMD) in Patients Wearing Double Complete Dentures, Removable Partial Dentures and Dentistry Students at State University of West of Paraná - UNIOESTE
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Keywords: Temporomandibular disorders.
Dental prosthesis.
Dental students
Lead sponsor: Universidade Estadual do Oeste do Paraná
Sponsor class: OTHER
First posted: 2012-09-06
Enrollment: 210
Sex: ALL
Minimum age (years): 19
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Seventy dental students of State University of West of Paraná - UNIOESTE, seventy patients treated at the UNIOESTE Dental Clinic that wore removable partial denture (partially edentulous) and seventy patients with double complete dentures treated in Center for Dental Specialties of Cascavel, Paraná, Brazil.

Brief summary: It was proposed in this study to evaluate the prevalence of TMD signs and symptoms in State University of West of Parana's dental students with natural dentition, in patients with removable partial dentures and double complete dentures.

Detailed description: The Temporomandibular Disorder (TMD) has a high prevalence among the population. Objectives: To evaluate the prevalence of signs and symptoms of TMD. Methodology: 210 randomly selected individuals were evaluated, being divided into three groups with seventy individuals each: Group 1 - dental students with natural dentition. Group 2 - patients with removable partial dentures. And Group 3 - patients with double complete dentures. The questionnaire of the American Academy of Orofacial Pain for triage was employed, then, clinical evaluation was carried out.

Eligibility criteria: Inclusion Criteria:

- Patients wearing double complete denture, patients wearing just removable partial denture and dentate students.

Exclusion Criteria:

Students in orthodontic treatment or with less than one year after the end of orthodontic treatment were excluded from the research.

Primary outcomes:
measure: Assessment of the prevalence of signs and symptoms of temporomandibular disorders in patients with removable partial dentures, complete double dentures and toothed.
timeFrame: 5 months
Secondary outcomes:
measure: questionnaire for selection of orofacial pain and temporomandibular disorders recommended by the American Academy of Orofacial Pain
timeFrame: 5 monts
Other outcomes:
measure: Clinical examination
timeFrame: 5 months
Locations:
city: Cascavel
country: Brazil
facility: Universidade Estadual do Oeste do Paraná
state: Paraná
Study officials:
affiliation: Universidade Estadual do Oeste do Paraná
name: Maristela Pezzini, Professor
role: PRINCIPAL_INVESTIGATOR
affiliation: Universidade Estadual do Oeste do Paraná
name: Thaisa Bordin, Student
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01256021: The Efficacy and Safety of MEDITOXIN® in Children With Cerebral Palsy
Official title: Multi-center, Single Arm, Open-label, Phase IV Clinical Trial to Evaluate the Safety and Efficacy of MEDITOXIN® in Children With Cerebral Palsy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Muscle Spasticity
Lead sponsor: Medy-Tox
Sponsor class: INDUSTRY
First posted: 2010-12-08
Enrollment: 212
Sex: ALL
Minimum age (years): 2
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy and safety of Meditoxin® in the treatment of children with cerebral palsy.

Detailed description: The allocated subject is injected Meditoxin® 4U/kg body weight(for patients with hemiplegia) or 6U/kg body weight(for patients with diplegia)in the affected gastrocnemius muscle for the treatment of patients who suffer Equinus Foot Deformity with pediatric cerebral palsy due to spasticity.

The efficacy and safety are evaluated for 12weeks through 3 follow up visits.

Eligibility criteria: Inclusion Criteria:

* Pediatric patients aged between 2 and 18 years with diagnosis of spastic cerebral palsy
* Patients with toe-walking due to peroneal muscle spasticity (patients with equinus foot deformity due to spasticity)
* Patients who voluntarily consent to participate in this study and whose legally acceptable representative has signed the informed consent form (if the patient is able to write, his/her signature should be also obtained).

Exclusion Criteria:

* Patients who had previously received botulinum toxin within 3 months prior to the study entry
* Patients with known hypersensitivity to botulinum toxin
* Patients who requires legs, feet or ankle surgery at present
* Patients with severe athetoid movement
* Patients who is participating in other investigational study at present
* Patients, by the investigator's discretion, who are not suitable for this study.

Primary outcomes:
measure: Mean change from baseline in MAS score from baseline to week 4
timeFrame: 4 weeks
Secondary outcomes:
measure: Mean change from baseline in MAS score from baseline to week 12
timeFrame: 12 weeks
measure: Mean change from baseline in PROM(Passive Range of Motion of ankle) at ankle dorsiflexion from baseline to week 4, 12
timeFrame: 4, 12 Weeks
measure: Mean change from baseline in VAS(Visual Analogue Scale)assessed by caregiver/patient from baseline to week4
timeFrame: 4, 12 weeks
measure: Improvement in Global Assessment assessed by caregiver/patient
timeFrame: 4, 12 weeks
Other outcomes:
Locations:
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National Universtiy Hospital
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Yonsei University Severance Hospital
Study officials:
affiliation: Severance Hospital
name: Eun S Park, Ph D
role: PRINCIPAL_INVESTIGATOR
References: