Clinical trial NCT00053690: Treatment of Post Traumatic Stress Disorder in Patients With Other Mental Illnesses
Official title: Cognitive-Behavioral Treatment of PTSD in SMI Clients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stress Disorders, Post-Traumatic
Keywords: Comorbidity
Schizophrenia
Bipolar Disorder
Depression
Lead sponsor: Dartmouth-Hitchcock Medical Center
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2003-02-05
Enrollment: 88
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to develop an effective treatment for people with Post Traumatic Stress Disorder (PTSD) along with other mental illnesses.

Detailed description: Despite the progress in treating PTSD in the general population and the elevated prevalence of PTSD in people with severe mental illness (SMI), there are no empirically validated treatments designed for patients with comorbid PTSD. The cognitive behavioral treatment provided in this study may improve knowledge of PTSD, decrease distorted beliefs, reduce PTSD symptoms, and improve quality of life.

Participants are randomly assigned to receive either a cognitive behavioral treatment plus standard care for SMI or standard care alone. The cognitive behavioral treatment incorporates several common features, including psychoeducation, relaxation training, and cognitive restructuring. Standard care for SMI includes medication, case management, and psychosocial treatment. PTSD, psychiatric symptoms, health, quality of life, and substance abuse outcomes are measured. Participants' knowledge of PTSD and beliefs about the world are also measured. Participants are assessed at baseline, post-treatment (16 weeks), and at 3- and 6-month follow-ups.

For information on a related study, please follow this link:

http://clinicaltrials.gov/show/NCT00494650

Eligibility criteria: Inclusion Criteria:

* Post Traumatic Stress Disorder
* New Hampshire definition of SMI plus DSM-IV Axis I diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or major depression
* Case management services and contact with a case manager at least twice a week

Exclusion Criteria:

* Alcohol or drug dependence
* Hospitalization or suicide attempt in the past 2 months

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Claremont
country: United States
facility: Community Mental Health Centers in NH
state: New Hampshire
Study officials:
affiliation: Dartmouth-Hitchcock Medical Center
name: Kim Mueser, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Dartmouth-Hitchcock Medical Center
name: Stanley Rosenberg, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mueser KT, McGurk SR, Xie H, Bolton EE, Jankowski MK, Lu W, Rosenberg SD, Wolfe R. Neuropsychological predictors of response to cognitive behavioral therapy for posttraumatic stress disorder in persons with severe mental illness. Psychiatry Res. 2018 Jan;259:110-116. doi: 10.1016/j.psychres.2017.10.016. Epub 2017 Oct 6.