louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00149123: Low-dose Hydrocortisone in Acutely Burned Patients
Official title: Low-dose Hydrocortisone in the Treatment of the Shock of Burned Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Burns
Keywords: Burn
adrenal insufficiency
hydrocortisone
short corticotropin test
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2005-09-08
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Major burns trigger the release of circulating mediators, as cytokines and endotoxin that induces a systemic inflammatory response syndrome. The cardiovascular effects are similar to those seen in septic shock. After the initial hypovolemic phase, patients with extensive burns often present a shock with increased cardiac output and reduced systemic vascular resistances. As described in septic shock, we test the hypothesis that low-dose hydrocortisone could decrease the duration of the shock period.


Eligibility criteria: Inclusion Criteria:

* males and females,
* between 18 and 75 year old
* who present a burned surface more than 30% of the body surface
* who need catecholamine infusion
* between J0 and J3 after the injury.

Exclusion Criteria:

* pregnancy,
* trauma,
* sepsis,
* cardiac insufficiency,
* AIDS,
* etomidate administration

Primary outcomes:
measure: Number of patients who do not receive any more catecholamine 4 days after the beginning of the shock
Secondary outcomes:
measure: Duration of catecholamine administration
measure: Doses of administered catecholamine
measure: Adrenal insufficiency incidence
Other outcomes:
Locations:
city: Lyon
country: France
facility: Sylvie TISSOT
Study officials:
affiliation: Hospices Civils de Lyon
name: Sylvie TISSOT, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Plassais J, Venet F, Cazalis MA, Le Quang D, Pachot A, Monneret G, Tissot S, Textoris J. Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial. Crit Care. 2017 Jun 16;21(1):158. doi: 10.1186/s13054-017-1743-9.
citation: Venet F, Plassais J, Textoris J, Cazalis MA, Pachot A, Bertin-Maghit M, Magnin C, Rimmele T, Monneret G, Tissot S. Low-dose hydrocortisone reduces norepinephrine duration in severe burn patients: a randomized clinical trial. Crit Care. 2015 Jan 26;19(1):21. doi: 10.1186/s13054-015-0740-0.
Clinical trial NCT06476223: Artificial Saliva Containing Cumin and Ginger Extract in Hemodialysis Patients With Xerostomia
Official title: Efficacy and Safety of Artificial Saliva Containing Cumin and Ginger Extract in Hemodialysis
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Xerostomia
Lead sponsor: Chulalongkorn University
Sponsor class: OTHER
First posted: 2024-06-26
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Hemodialysis patients with xerostomia are divided into 2 groups which are group A (start with artificial saliva containing cumin and ginger extract for 2 weeks, free periods 2 weeks, then placebo for 2 weeks) and group B (start with placebo for 2 weeks, free periods 2 weeks, then artificial saliva containing cumin and ginger extract for 2 weeks). Amount of saliva (g/min), xerostomia's questionnaire, Increase of saliva score, World Health Organization Oral Mucositis Grading Scale, acid and base of saliva, quality of life's questionnaire will measure before, after using the sample for 7 and 14 days.


Eligibility criteria: Inclusion Criteria:

* Age more than 18 years
* Hemodialysis patients with xerostomia (saliva flow rate less than 0.2 g/min)
* Hemodialysed history more than 3 months
* Be willing to participate in the study

Exclusion Criteria:

* Patients with sialolith or Sjogren's syndrome
* Uncontrolled other diseases
* Using artificial saliva for more than 2 weeks
* Taking pilocarpine and cevimeline
* Allergic to ginger, cumin, xylitol, and glycerin
* Have mucositis
* Pregnancy or lactation

Primary outcomes:
measure: Xerostomia symptoms using Xerostomia Inventory Score
timeFrame: 14 days
Secondary outcomes:
measure: Salivary flow rate
timeFrame: 14 days
measure: Amount of saliva score
timeFrame: 14 days
measure: Quality of life score using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35
timeFrame: 14 days
measure: World Health Organization Oral Mucositis
timeFrame: 14 days
measure: Acid and base of saliva
timeFrame: 14 days
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01319123: Evaluate the Impact of Drawtex in Venous Leg Ulcers
Official title: Clinical Study to Comparatively Evaluate the Impact of Drawtex Wound Dressing Against Wound Bioburden in Moderately to Highly Exuding Venous Leg Ulcers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Moderatley to Highly Exuding Venous Leg Ulcers
Keywords: dressing for venous leg ulcers
Lead sponsor: Southwest Regional Wound Care Center
Sponsor class: OTHER
Collaborators: name: Beier Drawtex Healthcare, (PTY). Ltd
First posted: 2011-03-21
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a clinical study to comparatively evaluate the impact of Drawtex wound dressing against wound bioburden in moderately to highly exuding venous leg ulcers.

Detailed description: Each subject is expected to participate in this study for a period of four weeks or until reepithelialization, whichever occurs first. Subjects may participate for an additional period of four weeks or until reepithelialization, whichever occurs first: this it to be decided by the investigator and will be determined by the accessibility of the patient (physical location) and the suitability of the wound to further treatment. The maximum time period for the study is 8 weeks. The minimum time frame is at least 4 week, or until reepithelialization occurs.

Eligibility criteria: Inclusion Criteria:

* Subject \> 18 years.
* Subject is attending weekly office visits at SW Wound Care Center as an out-patient.
* Subject has a moderately to highly exudative venous leg ulcer that would be indicated for treatment with Drawtex
* Subject or is informed about the trial, understands its nature of the study and provides written informed consent prior to study enrollment.
* Subject is willing and able to comply with all specified care and visit requirements

Exclusion Criteria:

* Subject has a lesion that does not meet the inclusion criteria.
* Subject refuses to participate in the study.
* Subject already participates in the this study with one wound (only one wound per subject is allowed)
* Subject has known sensitivity to the trial product or any of its compounds.
* Subject is expected to be non-compliant.
* Subject's lesion is a primary skin cancer.
* Subject's lesion is the manifestation of a metastasis.
* Subject is pregnant.

Primary outcomes:
measure: To investigate the impact of Drawtex on wound surface bioburden.
timeFrame: 2 years
Secondary outcomes:
measure: Tolerance
timeFrame: 2 years
Other outcomes:
Locations:
city: Lubbock
country: United States
facility: Southwest Regional Wound Care Center
state: Texas
Study officials:
affiliation: Southwest Regional Wound Care
name: Randall D Wolcott, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04686123: Efficacy of a Supervised Intervention Protocol on Rounded Shoulder Posture and Shoulder ROM Among Saudi Young Females
Official title: Effectiveness of Strengthening and Stretching Exercise on the Resting Length of Pectoralis Minor Muscle and Shoulder Flexion of Young Females With Rounded Shoulder Posture
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postural; Defect
Keywords: Round shoulder posture
Active Stretching
Pectoralis Muscles
Strength Training
Trapezius Muscle
Lead sponsor: King Saud University
Sponsor class: OTHER
Collaborators: name: Majmaah University
First posted: 2020-12-28
Enrollment: 60
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two-arm parallel groups randomized clinical trial
Primary purpose: TREATMENT

Brief summary: Shortening of pectoralis minor (PMi) muscle affects the scapular excursion that results in limited shoulder flexion range of motion (SFROM). The purpose is to evaluate the effect of Stretching of PM muscle along with the strengthening of lower trapezius (LTR) muscle to increase the length of PM muscle (PML) and limited SFROM in young adult females with rounded shoulder posture.

Detailed description: Shortening of pectoralis minor (PMi) muscle affects the scapular excursion that results in limited shoulder flexion range of motion (SFROM). The purpose is to evaluate the effect of Stretching of PM muscle along with the strengthening of lower trapezius (LTR) muscle to increase the length of PM muscle (PML) and limited SFROM in young adult females with rounded shoulder posture.

Randomized sixty female subjects with rounded shoulder posture into two groups: Group A performed active Stretching of PMi along with the strengthening of LTR muscle(n=30); group B performed dynamic Stretching of PMi muscle only. Scores of outcome measures were recorded before and post interventions on day 0, day10th, and day21st, respectively.

Eligibility criteria: Inclusion Criteria:

* Young Adult Female having a PMLD test score of more than 2.5cm
* Aged between 20-30 years
* No history of shoulder trauma or current shoulder pathology, thoracic scoliosis, or kyphosis deformity.
* Showed self-cooperation for the study

Exclusion Criteria:

* Young Adult Female having a PMLD test score of equal to or less than 2.5cm
* History of shoulder trauma or current shoulder pathology, thoracic scoliosis, or kyphosis deformity.
* Showed non-cooperation for the study

Primary outcomes:
measure: Resting length of Pectoralis Minor (PMi) muscle
timeFrame: 3-weeks
measure: Shoulder Flexion Range of Motion (SFROM)
timeFrame: 3-weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Riyadh
country: Saudi Arabia
facility: Rehabilitation Research Chair
Study officials:
affiliation: King Saud University
name: AMIR IQBAL, MPT-Ortho
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06668350: Attitudes and Perceptions Attitudes and Smoking Perceptions in the Real Environment -II
Official title: Racial/Ethnic Differences in Appeal and Preference for Flavored Little Cigars/Cigarillos: A Multi-Method Approach to Inform Tobacco Policy
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Cigarillo Flavor
Lead sponsor: University of Oklahoma
Sponsor class: OTHER
First posted: 2024-10-31
Enrollment: 190
Sex: ALL
Minimum age (years): 18
Maximum age (years): 34
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: This multi-method project will recruit young adults who currently use cigarillos and examine the effects of different flavored cigarillo types (concept, characterizing, tobacco) on three measures of tobacco product appeal: subjective effects (e.g., taste, enjoyment, satisfaction, reward), actual smoking behavior (e.g., number of puffs), and tobacco product purchases via a simulated experimental tobacco marketplace.


Eligibility criteria: Inclusion Criteria:

* Ages18 to 34
* Smoke a little cigar or cigarillo (LCCs) "some days" or "everyday" (verified by brand name of the product);
* Ability to read English at an 8th grade level or higher; and
* No immediate plans to quit using tobacco
* \> 1 prior experience, even 1 puff, with a flavored tobacco product
* U.S. Citizen or permanent resident of the United States.

Exclusion Criteria:

* Current use of nicotine replacement therapy (NRT) or stop smoking medication;
* Pregnant, planning to become pregnant, or currently breastfeeding;
* Past or current self-reported clinically significant heart disease or hypertension, or other smoking-related disease (by history) that preclude successful study completion;
* Inability to abstain from nicotine/tobacco products for at least 12 hours prior to lab sessions
* Report using the study cigarillo brand as their preferred brand (as this will likely unduly influence their perceptions)
* Unwillingness to use "untipped" (e.g., plastic or wood tip) little cigars/cigarillos.

Primary outcomes:
measure: Puff volume
timeFrame: From enrollment to the end of the study at 6 weeks
measure: Subjective effects from smoking
timeFrame: From enrollment to the end of the study at 6 weeks
measure: Exhaled carbon monoxide
timeFrame: From enrollment to the end of the study at 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Oklahoma City
country: United States
facility: TSET Health Promotion Research Center
state: Oklahoma
Study officials:
References:
Clinical trial NCT03358550: Night Myopia and Dark Focus of Accommodation
Official title: Influence of an Imaginary Target on the State of Accommodation Under Scotopic Conditions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dark Focus of Accommodation
Keywords: accommodation
dark focus
night myopia
Lead sponsor: University of Applied Sciences Jena
Sponsor class: OTHER
First posted: 2017-11-30
Enrollment: 39
Sex: ALL
Minimum age (years): 22
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Shifts in accommodation at decreasing luminance levels are considered as principle cause for night myopia. Previous studies with laser optometers quantified the dark focus of accommodation up to 3 D. In addition to the measurement of dark focus, the aim of this study was to investigate the influence of an imaginary target at finite distances on the state of accommodation at scotopic luminance.

Detailed description: Accommodation was measured by using an open-field autorefractor (WAM 5500, GRAND SEIKO). Full corrected right eyes of 39 subjects aged from 18 to 40 years were investigated in this randomized, cross-sectional study. Accommodation measurements in photopic luminance were taken for 6 m of empty field and for optotype fixation at 2 m, 1 m and 0.5 m. At scotopic luminance, dark focus of accommodation was examined directly after darkening and after 10 min of dark adaptation. After adaptation, subjects had to visualize imaginary targets in the four distances while accommodation was measured.

Eligibility criteria: Inclusion Criteria:

* age 18 - 44
* visual acuity at least 0.8 (5/6)

Exclusion Criteria:

* medication with an impact on the visual system
* visual disease or disease with an impact on the visual system
* pregnancy or other hormonal variances
* drug usage
* overfatigue at the period of investigation
* mental handicap

Primary outcomes:
measure: Shift of accommodation in scotopic luminance (Dark focus)
timeFrame: Baseline only
Secondary outcomes:
measure: Difference of accommodation for 2 m target
timeFrame: Baseline only
measure: Difference of accommodation for 1 m target
timeFrame: Baseline only
measure: Difference of accommodation for 0.5 m target
timeFrame: Baseline only
Other outcomes:
Locations:
city: Jena
country: Germany
facility: University of Applied Sciences
state: TH
Study officials:
affiliation: University of Applied Sciences Jena
name: Philipp Hessler, M.Sc.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04620850: Effect of Acupressure on Recovery of Bowel Function in Patients Post Cesarean Section
Official title: Effect of Acupressure on Recovery of Bowel Function in Patients Post Cesarean Section
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acupressure
Post-Op Complication
Cesarean Section
Bowel Ileus
Lead sponsor: Department of Medical Services Ministry of Public Health of Thailand
Sponsor class: OTHER_GOV
First posted: 2020-11-09
Enrollment: 48
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Research objectives To compare the efficacy of acupressure with no acupressure to examine time to first flatus in patient post cesarean section

; Acupressure at ST-36 Zusanli (lateral to anterior crest of tibia, in the tibialis anterior muscle)

Research hypothesis Patients who received acupressure will have earlier flatus passage

Detailed description: Research design Randomized controlled trial. Compare between The investigators is who assess the acupressure with control group is the participants do not assess the acupressure

Eligibility criteria: Inclusion Criteria:

1. Pregnancy woman age 18-45 years
2. General anesthesia
3. Co-operate in research
4. Can speak in thai language

Exclusion Criteria:

1. Twin pregnancy
2. Placenta previa
3. Placental abruption
4. Chorioamnionitis
5. Complication intraoperation (Bowel or bladder injury)
6. Post partum hemorrhage
7. Abdominal adhesion
8. Opertative time more than 2 hour
9. History gastrointestinal surgery
10. Prior acupressure
11. Neurological disease
12. Neuromuscular disease
13. Hepatic disease

Primary outcomes:
measure: To study the duration of the first time to flatus passage in post cesaren section patient
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: To study the duration of the first time to have bowel sound in post cesaren section patient
timeFrame: through study completion, an average of 1 year
measure: To study the duration of the first time to pass stool in post cesaren section patient
timeFrame: through study completion, an average of 1 year
measure: To study the symptomatic about Nausea/vomiting in post cesaren section patient
timeFrame: mild
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Rajavithi Hospital
Study officials:
affiliation: Department of Medical Services Ministry of Public Health of Thailand
name: Sasiwimol kunnitikorn, MD
role: STUDY_CHAIR
References:
Clinical trial NCT01113450: Results of a Program of Newborn Hearing Screening (NHS) in Cuiaba-Brazil
Official title: Results of a Program of Newborn Hearing Screening in Cuiaba-Brazil
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Showing the Results of a Program of NHS in Cuiaba_ Brazil
Keywords: hearing, newborn, screening
Lead sponsor: Centro de Diagnostico Auditivo de Cuiaba
Sponsor class: OTHER
First posted: 2010-04-30
Enrollment: 3148
Sex: ALL
Minimum age (years): 2
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: yes
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: There were two groups:

1. high risk for hearing loss
2. low risk for hearing loss

Brief summary: The study aims to demonstrate the indices of quality of a Newborn Hearing Screening (NHS).

Detailed description: The data refer to infants underwent newborn hearing screening by evoked otoacoustic emissions by transient stimulation, using the analyzer EOA Biologic. Examinations archived in the computer's service were analyzed for the amount of infants who passed or failed the screening, as well as the correlations with the same age and gender.

Eligibility criteria: Inclusion Criteria:

* middle ear conditions integrates

Exclusion Criteria:

* middle ear conditions inadequate

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Cuiaba
country: Brazil
facility: CEDAC
state: Mato Grosso
Study officials:
affiliation: Centro de Diagnostico Auditivo de Cuiaba
name: Priscila L Rodrigues, PHD student
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03638050: The Safety of the 6-minute Walk Test After Acute Myocardial Infarction
Official title: The Safety of the 6-minute Walk Test After Acute Myocardial Infarction
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Myocardial Infarction
Six-minute Walk Test
Lead sponsor: Federal University of São Paulo
Sponsor class: OTHER
First posted: 2018-08-20
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Sequential AMI patients admitted to hospitalization in the third day after myocardial infarction

Brief summary: Background: The six-minute walk test (6MWT) is widely used as an instrument for assessing the functional capacity of cardiac patients. It's a simple, low cost test that better reflects day-to-day activities when compared to other tests. Its use to evaluate the functional capacity of cardiac patients in the in-hospital phase after acute myocardial infarction requires further studies. Objective: To evaluate the safety of the 6MWT performed on the third day after acute myocardial infarction (AMI). Methods: It's a cross-sectional study, to be accomplished in Hospital São Paulo - Federal University of Sao Paulo. Individuals, of both genders, aged 18 years and over, will be assessed on the third day after acute myocardial infarction. The 6MWT will be performed according to the norms of the American Thoracic Society. The distance covered during the 6MWT will be measured as weel as adverse events.


Eligibility criteria: Inclusion Criteria:

* AMI patients

Exclusion Criteria:

* Previous history of AMI
* Recurrent or refractory pain
* Presence of neuromuscular diseases
* Acute or chronic lung diseases
* Inability to perform the functional test

Primary outcomes:
measure: Six-minute walk test to measure functional capacity
timeFrame: Third day after acute myocardial infarction
Secondary outcomes:
measure: Angina
timeFrame: Third day after acute myocardial infarction
measure: Dyspnea
timeFrame: Third day after acute myocardial infarction
measure: Pallor
timeFrame: Third day after acute myocardial infarction
measure: Sweating
timeFrame: Third day after acute myocardial infarction
measure: Cramps
timeFrame: Third day after acute myocardial infarction
measure: Lower limbs fatigue
timeFrame: Third day after acute myocardial infarction
measure: Dizziness
timeFrame: Third day after acute myocardial infarction
measure: Hospitalization stay
timeFrame: Thirty days after acute myocardial infarction
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Graciana Santos Martinhão
Study officials:
References: