Clinical trial NCT05018884: Surgical Site Infections at a West Cameroon Hospital
Official title: Incidence, Microbial Spectrum and Risk Factors of Surgical Site Infections at a West Cameroon Hospital: A Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Surgical Wound Infection
Lead sponsor: Universite Evangelique du Cameroun
Sponsor class: OTHER
Collaborators: name: Charite University, Berlin, Germany
First posted: 2021-08-24
Enrollment: 148
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients that receive surgery at the Hôpital Protestant de Mbouo in Cameroon and that are willing and consenting to participate in the study

Brief summary: Surgical site infections (SSI) constitute an important health concern in low and middle income countries, leading to prolonged hospital stay and increased costs. Previous studies indicate that in Africa up to 1/3 of patients undergoing surgery may be affected by a postoperative infection. The development and implementation of context-specific SSI prevention guidelines is important to reduce this complication. To deploy efficient context-specific measures, data on epidemiology and microbiology of these infections are needed. This means to adapt the prevention measures to the context-specific risk factors for surgical site infections in resource-limited settings, and to give locally adapted recommendations on antimicrobial therapy based on local resistance patterns. However, data in this respect are scarce in low and middle income countries. This present study will contribute to the needed epidemiology and microbiology data on SSI in Cameroon. It will be carried out as a prospective cohort study at the Mbouo Protestant hospital in the West Region of Cameroon. The incidence, microbial spectrum and respective antimicrobial resistance of SSI as well as the risk factors of SSI will be systematically investigated. The study will include 300 patients at the Hôpital Protestant de Mbouo (HPM) who underwent surgery and gave their informed consent for inclusion, the timeframe is 04/2021 - 11/2021. An active SSI surveillance system will be put in place for 30 postoperative days to diagnose SSI.

Expected outcomes:

The incidence of SSI is likely to be higher than 10%. Concerning risk factors, preoperative bodywashing and perioperative antibioprophylaxis is expected to be protective against SSI. Up to 1/3 of SSI are expected to occur after hospital discharge. For the microbial spectrum, a high proportion of Staphylococcus aureus is likely to be found. For the antimicrobial resistance no estimation can be give as data is non-existent in that region from the literature.


Eligibility criteria: Inclusion Criteria:

* Patient underwent surgery at the hospital during study period

Exclusion Criteria:

* Unconscious patients, mentally ill patients

Primary outcomes:
measure: Incidence of Surgical Site Infections (SSI)
timeFrame: 04 / 2021 - 11 / 2021
Secondary outcomes:
measure: Risk factors of SSI
timeFrame: 04 / 2021 - 11 / 2021
measure: Microbial spectrum of SSI
timeFrame: 04 / 2021 - 11 / 2021
measure: Post-operative mortality
timeFrame: 04 / 2021 - 11 / 2021
Other outcomes:
Locations:
city: Bafoussam
country: Cameroon
facility: Hôpital Protestant de Mbouo
state: Ouest
Study officials:
affiliation: Université Evangélique du Cameroun, Cameroon; Hôpital Protestant de Mbouo, Cameroon; Charité University Medical Centre Berlin, Germany; University Medical Centre Jena, Germany
name: Christian Doll, Dr
role: PRINCIPAL_INVESTIGATOR
References: