Clinical trial NCT05513521: Speed-specific Training and Ultrasound
Official title: Velocity- Versus Load-based Training on Muscle Quality and Performance in Older Persons
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: High-Intensity Interval Training
Resistance Training
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2022-08-24
Enrollment: 25
Sex: ALL
Minimum age (years): 55
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Compare velocity-based interval resistance training to load-based resistance training
Primary purpose: TREATMENT

Brief summary: The investigators propose to compare the effects of a 12-week load resistance training program to a velocity resistance training program on ultrasound measures of quadriceps muscle quality in a healthy, older adult population. As secondary measures, The investigators propose to compare the effects of these exercise programs on maximal strength, power, and functional movements such as the chair sit-to-stand and gait speed. Further, The investigators will evaluate the impact of each protocol on cognitive function.

Detailed description: Resistance training has been shown to have a significant impact on strength, power, cognition, functionality, activities of daily living, and quality of life throughout the aging process(Hunter et al., 2004; Peterson et al., 2010; Wen et al., 2011). Specifically, power training is especially beneficial to older adults to combat the age-related slowing of movement that occurs. and changes in age-related cognitive decline. However, in evaluating these measures and prescribing a power training program, the deficit on either the load or velocity end of the power spectrum unique to these individuals is often overlooked. Therefore, the evaluation of these components coupled with a custom training program to fit their needs on either the load end or velocity end of the spectrum may provide significant benefit to the functionality of older adults. Additionally, sleep quality has been shown to have a significant impact on cognitive performance(Alhola \& Polo-Kantola, 2007) and may impact the changes in cognition that The investigators observe with a resistance training program.

Further, muscle mass has been shown to decrease with aging as a result of a variety of physiological changes that occur in the body, including the reduction in motor units and muscle fibers and these changes have a significant impact on the mobility of older adults(Charlier et al., 2016; Evans \& Campbell, 1993). Resistance training has been shown to have an impact on the progression and development of sarcopenia and has been supported in the research with both the use of power and strength training programs(Balachandran et al., 2014; Roth et al., 2000). Ultrasonography evaluation of muscle quality can provide valuable information on the changes to the musculature that occur with training programs in older adults(Pardo et al., 2018).

While the impact of power and strength training on muscle quality has been shown(Ivey et al., 2000; Nogueira et al., 2009), the impact of a unique load velocity design to target power deficits on muscle quality is prohibitive. Therefore, this research is designed to evaluate the impact of load training and velocity training on muscle quality in healthy, older adults as well as changes in functionality, cognition, and sleep.

Eligibility criteria: Inclusion Criteria:

* Montreal Cognitive Assessment (MOCA) \> 23 and no memory loss complaints.

Exclusion Criteria:

* Any uncontrolled cardiovascular or neuromuscular diseases that prevent participation in a training program; Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, system lupus erythematosus, or other serious concomitant medical illness; Unresolved injury or surgery to the quadricep muscles

Primary outcomes:
measure: Five-time sit-to-stand
timeFrame: 5 minutes
measure: 10-meter walk
timeFrame: 5 minutes
measure: One-repetition maximum (1RM) testing
timeFrame: 10 minutes
measure: Home Sleep Testing
timeFrame: 8 hours
measure: Actigraphy
timeFrame: 168 hours
Secondary outcomes:
measure: Dimensional Card Sort (DCCS)
timeFrame: 5 minutes
measure: Flanker test
timeFrame: 5 minutes
measure: Picture Sequence Memory Test (PSMT)
timeFrame: 5 minutes
measure: List Sorting Test
timeFrame: 5 minutes
measure: Pattern Comparison Test
timeFrame: 5 minutes
measure: Power Testing
timeFrame: 15 minutes
measure: Ultrasound measurement
timeFrame: 15 minutes
measure: Isokinetic Testing
timeFrame: 30 minutes
Other outcomes:
Locations:
city: Coral Gables
country: United States
facility: Laboratory of Neruomuscular Research and Active Aging
state: Florida
Study officials:
affiliation: University of Miami
name: Joseph F Signorile, PhD
role: PRINCIPAL_INVESTIGATOR
References: