louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06623643: &#34;Salivary Melatonin and Cortisol Levels in Individuals with Bruxism&#34;
Official title: The Investigation of Melatonin and Cortisol Levels in the Saliva of Individuals with Bruxism
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Bruxism
Keywords: melatonin
saliva
cortizol
Lead sponsor: Yuzuncu Yıl University
Sponsor class: OTHER
First posted: 2024-10-02
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: ndividuals with and without bruxism

Brief summary: The effects of the hormones melatonin and cortisol, which play a highly effective role in regulating the sleep-wake cycle, on teeth grinding will be scientifically evaluated. Based on the research results, more effective methods for treating patients suffering from bruxism may be identified.


Eligibility criteria: Inclusion Criteria:

- Individuals without any known hormonal diseases, not using antidepressants or medications that could alter saliva content, without degenerative diseases affecting the salivary glands, without cysts or tumors affecting the temporomandibular region, and not undergoing insomnia treatment will be included in the study

Exclusion Criteria:

* Individuals with systemic diseases that affect or may potentially affect saliva content, or those using medications that cause these effects, will not be included in the study

Primary outcomes:
measure: levels of melatonin
timeFrame: Baseline assessment at the start of the study, follow-up assessments at 3 months and 6 months, with final data collection at 12 months.
measure: levels of cortisol
timeFrame: Baseline assessment at the start of the study, follow-up assessments at 3 months and 6 months, with final data collection at 12 months.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00303043: Hemodynamic Monitoring With Mixed Venous Saturation
Official title: Hemodynamic Monitoring. The Continuous Measurement of Mixed Venous Saturation Compared to Clinical Valuation: A Pilot Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Critically Ill
Keywords: Hemodynamic monitoring
Mixed venous saturation
Critically ill patients
Lead sponsor: Policlinico Hospital
Sponsor class: OTHER
First posted: 2006-03-15
Enrollment: 30
Sex: ALL
Minimum age (years): 16
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Critically ill patients with a central venous catheter

Brief summary: In this study the investigators aim to evaluate the utility of a continuous mixed venous saturation monitoring compared to a clinical examination in a group of critically ill patients.

Detailed description: We will compare possible difference in terms of sensibility and specificity regarding the continuous mixed venous saturation monitoring compared to clinical examination in a group of critically ill patients.

Eligibility criteria: Inclusion Criteria:

* Critically ill patients with a central venous catheter

Exclusion criteria:

* Patients with pulmonary catheter

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Milano
country: Italy
facility: Fondazione Ospedale Maggiore Policlinico Mangiagalli Regina Elena
state: MI
Study officials:
affiliation: Fondazione Ospedale Maggiore Policlinico Mangiagalli Regina Elena
name: Davide Chiumello, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03490643: An Investigation Of The Relationship Between Temporomandibular Disorder With Posture And Pedobarographic Analysis
Official title: Temporomandibular Rahatsızlığın Postür ve Pedobarografik Ölçüm Sonuçları Ile İlişkisinin Araştırılması
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Temporomandibular Disorder
Keywords: Plantar Pressure Distribution
Posture
Posturescreen Mobile
RDC/TMD
TMD
Lead sponsor: Istanbul Medipol University Hospital
Sponsor class: OTHER
First posted: 2018-04-06
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: The aim of the study is, to evaluate the whole body posture and plantar pressure distributions in individuals with Temporomandibular Disorder and also in people with healthy temporomandibular joints. A study group aged between 18-35 years, 30 patients, who were diagnosed with Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) who applied us with jaw pain and 30 healthy people at the same age range as a control group were included in the study. Both groups received global postural assessments by using PostureScreen Mobile® (PSM) program which is using four side photographs and the New York Posture Scale (NYPS). Static pedobarographic measurements were taken.


Eligibility criteria: Inclusion Criteria:

* clinical diagnosis of Temporomandibular Diseases
* clinical diagnosis of healthy temporomandibular joint

Exclusion Criteria:

* Trauma history
* Anatomic deformities and skeletal system fractures
* Orthopedic or rheumatic diseases diagnosed
* Pregnancy
* Having TMR treatment
* Being included in the physiotherapy program in the last 6 months

Primary outcomes:
measure: flexion and extension degree
timeFrame: 5 minutes
measure: translation
timeFrame: 5 minutes
Secondary outcomes:
measure: plantar pressure distribution
timeFrame: 2 minutes
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Medipol University
state: Beykoz
Study officials:
affiliation: Medipol University
name: Gizem Ergezen
role: PRINCIPAL_INVESTIGATOR
affiliation: Medipol University
name: Zeliha Candan Algun
role: STUDY_DIRECTOR
References:
Clinical trial NCT02026843: Analysis of Biomarkers From Patients With Chorioretinal Diseases
Official title: Analysis of Biomarkers From Patients With Chorioretinal Diseases
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Diabetic Retinopathy
Macular Degeneration
Lead sponsor: Kyungpook National University Hospital
Sponsor class: OTHER
First posted: 2014-01-03
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A total of 100 patients will be included. 50 patients with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration. and 50 control patients scheduled for pars plana vitrectomy for nondiabetic retinal disease or phacoemulsification.

Brief summary: This study was conducted to investigate the levels of ocular biomarkers from the patients with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration.

Detailed description: This prospective, case-control study included 50 patients(50eyes) with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration. and 50 patient with nondiabetic retinopathy or cataract. Ocular fluids and blood samples were taken before injection of anti-vascular endothelial growth factor agent or pars plana vitrectomy for other retinal disease. Ocular biomarkers were analyzed.

Eligibility criteria: Inclusion Criteria:

* age over 20 years
* patients requiring ophthalmologic treatments for different degrees of decreasing of visual acuity.
* patients with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration.
* control patients asking cataract surgery or vitrectomy for posterior segment nonproliferative disorders.

Exclusion Criteria:

* under the age of 20 years
* patients that received any anti-vascular endothelial growth factor agent for proliferative disease before taking sample of aqueous humor
* patients that did not signed the informed consent of the trial
* patients with intraocular inflammations or infections that requiring any pharmaceutical agent
* patients with recent ocular trauma

Primary outcomes:
measure: Biomarkers in ocular fluids
timeFrame: one month
Secondary outcomes:
Other outcomes:
Locations:
city: Daegu
country: Korea, Republic of
facility: Dong Ho Park
state: Kyungsangpookdo
Study officials:
affiliation: Kyungpook National University Hospital
name: Dong Ho Park, M.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00863343: Clinical Validation of the Point-of-Care MSD Influenza Test
Official title: Clinical Validation of the Point-of-Care MSD Influenza Test
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Influenza Human
Keywords: Influenza infections
Orthomyxoviridae infections
Lead sponsor: Meso Scale Diagnostics, LLC.
Sponsor class: INDUSTRY
Collaborators: name: Centers for Disease Control and Prevention
First posted: 2009-03-18
Enrollment: 391
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals visiting a primary care site.

Brief summary: The primary objective of this study is to evaluate the performance of the MSD® Influenza Test in detecting influenza A and influenza B in subjects presenting with influenza-like-illness (ILI).

Detailed description: This is a multicenter, prospective study to evaluate the performance of the MSD Influenza Test for the detection and differentiation of influenza A (including A/H1, A/H3, and A/H5 subtypes) and influenza B. Nasal swabs from subjects presenting at the clinical care facility with ILI will be collected and tested on the MSD Influenza Test. Results from the Test will be compared to results obtained from viral culture performed on a second nasal swab at a reference laboratory.

Eligibility criteria: Inclusion Criteria:

* Any subject (all ages) presenting with ILI (defined as fever \[subjective or documented\] and cough or sore throat), and suspected of having influenza.
* Subject (parent, guardian, or authorized legal representative) gives informed consent or assent (child) to the study, and provides signed authorization for use and disclosure of protected health information.

Exclusion Criteria:

* Any subject classified as "high risk" for exposure to avian or novel influenza, as determined by a Risk-Assessment Questionnaire.
* Subjects who had prior nasal wash/aspirate or nasopharyngeal wash/aspirate specimens collected for routine health-care purposes within the same suspected influenza infection episode.

Primary outcomes:
measure: MSD Influenza A Test Results Against Cell Culture
timeFrame: 1 day
measure: MSD Influenza B Test Results Against Cell Culture
timeFrame: 1 day
measure: MSD Influenza A Test Results Against Culture and PCR
timeFrame: 1 day
measure: MSD Influenza B Test Results Against Culture and PCR
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: San Diego
country: United States
facility: Naval Health Research Center
state: California
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center
state: New Hampshire
city: Port Jefferson
country: United States
facility: John T Mather Hospital
state: New York
Study officials:
affiliation: Meso Scale Diagnostics
name: Jacqueline Perodin, PhD, CCRP
role: STUDY_DIRECTOR
References:
Clinical trial NCT05406843: Postoperative Cognitive Dysfunction in Heart Surgery
Official title: Postoperative Cognitive Dysfunction in Participants Undergoing Open Heart Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction
Keywords: COGNITIVE DYSFUNCTİON
HEART SURGERY
POSTOPERATIVE DELIRIUM
Lead sponsor: Kocaeli University
Sponsor class: OTHER
First posted: 2022-06-07
Enrollment: 140
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: A study was planned on 140 patients undergoing open heart surgery.

Brief summary: To determine the rate of Postoperative Cognitive Dysfunction (POCD) in the early and late postoperative periods by comparing the preop and postop period mini mental status tests in participants undergoing open heart surgery, and to compare the results of the investgators clinic with the world literature.

Detailed description: Postoperative delirium (POD) and Cognitive Dysfunction (POCD) are changes in mental status, especially in the geriatric surgery population.Unlike other forms of delirium, POD results in early full recovery.Postoperative Cognitive Dysfunction (POCD) is more difficult to define and implies temporal consciousness impairment associated with surgery.

While the diagnosis of delirium requires the detection of symptoms, the diagnosis of POCD requires preoperative neuropsychological testing and determining how much reduction will mean cognitive dysfunction. Postoperative delirium management is complex and requires multiple strategies. Methods of treating and preventing POCD are still uncertain.It is known that POCD is most commonly seen in patients undergoing open heart surgery.In this study, the investigators aim is to evaluate whether there is any change in cognitive status in the postoperative period compared to the preoperative period of participants who will undergo open heart surgery due to valve pathology or coronary stenosis.

Eligibility criteria: Inclusion Criteria:

* 18-75 age
* American Society of Anesthesiologists (ASA) II-III

Exclusion Criteria:

* \>75 age
* \<18 age
* Patients who died within 48 hours after the operation

Primary outcomes:
measure: Evaluation of postoperative cognitive functions in participants undergoing open heart surgery.
timeFrame: 1 year
Secondary outcomes:
measure: Comparison with the literature.
timeFrame: 1 year
Other outcomes:
Locations:
city: Kocaeli
country: Turkey
facility: Kocaeli Üniversitesi Tıp Fakültesi Hastanesi
state: İzmit
Study officials:
affiliation: Kocaeli University
name: Tülay Çardaközü
role: STUDY_DIRECTOR
References:
Clinical trial NCT03605043: Integrated Hypertension and HIV Care Cascades in Uganda
Official title: Integrated Hypertension and HIV Care Cascades in a HIV Treatment Program in Eastern Uganda: a Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hypertension
HIV
Keywords: Integrated
Care cascade
Uganda
Lead sponsor: Makerere University
Sponsor class: OTHER
First posted: 2018-07-30
Enrollment: 1649
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Persons Living with HIV (PLHIV) 18 years of age and above who were already diagnosed with HIV and enrolled into HIV care at any of the three sites between January 2014 and January 2017.

Brief summary: In this retrospective cohort study, we mapped the care cascades for both Hypertension and HIV within a HIV program in Uganda with the goal of identifying opportunities for developing contextually appropriate integrated care models, .

Detailed description: Persons living with HIV (PLHIV) and receiving anti-retroviral therapy (ART) are at increased risk of cardiovascular disease (CVD) due to direct effects of ART and HIV infection itself, compounded by traditional CVD risk factors such as increased life expectancy and Westernized diet. Additionally, in sub-Saharan Africa, as is the case globally, hypertension (HTN) is a major risk factor for CVD. The prevalence of HTN in the setting of HIV reported in the literature is variable but may be higher than in the HIV-negative population.

World Health Organization (WHO) and Ugandan national HIV guidelines have recommended the integration of hypertension care into HIV programs since 2014 and 2016, but there has been limited uptake of this recommendation in practice. There have been successful efforts to integrate tuberculosis, malaria, nutrition, maternal-child health, and family planning into HIV programmes in Uganda. In this study, with the goal of identifying opportunities for developing contextually appropriate integrated care models, we mapped the care cascades for both HTN and HIV within a HIV program in Uganda.

Eligibility criteria: Inclusion Criteria:

* 18 years of age and above, Having started Antiretroviral therapy between January 2014 and January 2017.

Exclusion Criteria:

* PLHIV receiving treatment from clinics other than the 3 selected sites.

Primary outcomes:
measure: Blood pressure control
timeFrame: 1 year
Secondary outcomes:
measure: HIV control
timeFrame: 1 year
Other outcomes:
Locations:
city: Kampala
country: Uganda
facility: Makerere University College of Health Sciences
state: Central
Study officials:
References:
Clinical trial NCT04949243: Rapid Acceleration for Diagnostics in Underserved Populations: Home Testing
Official title: Rapid Acceleration for Diagnostics in Underserved Populations: Home Testing
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2021-07-02
Enrollment: 338
Sex: ALL
Minimum age (years): 8
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults and children \> 8 years of age living within pre-identified communities participating in the public health intervention

Brief summary: This observational, cohort sub-studyis embedded within a larger public health intervention that distributes at-home, self-administered, SARS-CoV-2 antigen testing kits to households within pre-selected communitiesthrough the CDC.Within this sub-study, we will evaluate the socio-behavioral mechanisms of SARS-CoV-2 community transmission, including social interactions, health behaviors, healthcare utilization, knowledge, disease burden, and feasibility of at-home testing. The study hypothesis is that positive at-home test results will be associated withaltered self-reported social interactions and altered health behaviors compared to negative test results. Surveys and questionnaires will be completed by participants through the smartphone app or via call center phone calls according to the schedule of events.Questionnaires will collect data on demographic characteristics, medical history and health status, COVID testing and symptoms, social interactions, knowledge of prevention strategies, infection risk, and attitudes towards vaccines.


Eligibility criteria: Inclusion Criteria:

1. Self-reported primary residence within the pre-identified communities
2. Age\> 8 years at enrollment
3. Provision of signed and dated informed consent form

Exclusion Criteria: None if above are met

-

Primary outcomes:
measure: Number of Participants Who Reported Not Following Social Distancing Guidelines
timeFrame: 2 weeks
Secondary outcomes:
measure: Number of Participants That Avoided Public Spaces, Gatherings, or Crowds as a Prevention Measure
timeFrame: 2 weeks
measure: Number of Participants Who Are Knowledgeable of Precautionary Measures to Prevent Infection
timeFrame: 4 months
measure: Number of Participants With Positive SARs-CoV-2 Antigen Test Results
timeFrame: 4 months
measure: Number of Healthcare Utilization Measures
timeFrame: 4 months
Other outcomes:
Locations:
city: Greenville
country: United States
facility: Greenville Pitt County
state: North Carolina
city: Chattanooga
country: United States
facility: Hamilton County
state: Tennessee
Study officials:
affiliation: Duke University
name: christoph Hornik, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01898143: Cardiorespiratory Response During Whole Body Vibration Training in Patients With Chronic Lung Disease
Official title: Cardiorespiratory Response During Whole Body Vibration Training in Patients With Chronic Obstructive Pulmonary Disease (COPD) or Interstitial Lung Disease (ILD)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Obstructive Lung Disease (n=10)
Interstitial Lung Disease (n=10)
Keywords: Whole body vibration, cardiorespiratory response
Lead sponsor: Schön Klinik Berchtesgadener Land
Sponsor class: OTHER
First posted: 2013-07-12
Enrollment: 10
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Whole body vibration training seems to be a useful adjunct in exercise training in patients with severe COPD. The basic principle relies on reflectory muscle contractions caused by a vibration stimulus. Until now the impact of whole body vibration training on cardiopulmonary parameters remained unknown. Therefore aim of this study is to investigate cardiopulmonary parameters during whole body vibration training in patients with chronic lung disease.


Eligibility criteria: Inclusion Criteria:

* COPD stage III or IV according to the Global Initiative for chronic obstructive lung disease \[GOLD\])
* Interstitial Lung disease (forced vital capacity (FVC) \< 70% pred., diffusion capacity of lung for carbon monoxide (DLCO) 30-70% pred.)

Exclusion Criteria:

* Oxygen therapy during exercise required
* Severe exacerbation of lung disease, with necessity of change in medication or persistent symptoms \> 3days
* activated arthrosis /arthropathy/ rheumatoid Arthritis/ acute discopathy
* acute thrombosis
* acute musculoskeletal inflammation
* Epilepsy
* Gallstones

Primary outcomes:
measure: peak oxygen consumption (VO2 peak)
timeFrame: during 1 exercise session
Secondary outcomes:
measure: heart rate (HR)
timeFrame: during 1 exercise session
measure: minute ventilation (VE)
timeFrame: during 1 exercise session
measure: perceived exertion for dyspnea and leg fatigue (Borg-scale)
timeFrame: during 1 exercise session
measure: Alveolar-arterial oxygen difference (AaDO2)
timeFrame: during 1 exercise session
measure: breathing frequency (BF)
timeFrame: during 1 exercise session
measure: peak carbon-dioxide consumption (VCO2 peak)
timeFrame: during 1 exercise session
Other outcomes:
Locations:
city: Schönau am Königssee
country: Germany
facility: Schön Klinik Berchtesgadener Land
Study officials:
References: