louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04918550: A Survey on the Cognition and Use of Intraosseous Access Among Medical Staff
Official title: A Survey on the Cognition and Use of Intraosseous Access Among Emergency Medical Staff
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intraosseous Access
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2021-06-09
Enrollment: 3194
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Medical staff of emergency medicine in china

Brief summary: A Survey on the Cognition and Use of Intraosseous Access among Emergency Medical Staff, which is based on the platform of "WJX.CN", from January 5, 2018 to January 23, 2018, via local emergency-related academic organizations to emergency medical staff throughout the country. There are 3 sections in the questionnaire: the demographic information of the participants; cognition levels and clinical use of IO; barriers and attitudes towards clinical use of IO including willingness, confidence and training demand.

Detailed description: This research is a cross-sectional survey research, using the method of network survey, with domestic emergency medicine medical staff as the research object. Inclusion criteria: 1) Emergency medical staff who have a Chinese medical practitioner certificate or a nurse practitioner certificate and are within the valid registration period; 2) Agree to participate in this study. Exclusion criteria: incomplete questionnaires. The questionnaire was designed for the "Survey of Current Status of Marrow Cavity Pathway Cognition of Medical Staff in Emergency Department", including three parts: (1) general information of the survey object; (2) cognition and use status of IO; (3) clinical application of IO Attitude. Based on the "Questionnaire Star" platform, questionnaires are distributed through various emergency-related academic organizations. The front page of the questionnaire clearly marked the reminder of voluntary participation in the survey and related declarations, and it could be filled out after informed consent.

Eligibility criteria: Inclusion Criteria: 1) Emergency medical staff who have a Chinese medical practitioner certificate or a nurse practitioner certificate and are within the valid registration period; 2) Agree to participate in this study.

Exclusion Criteria: incomplete questionnaires.

Primary outcomes:
measure: Cognition levels and clinical use of IO
timeFrame: two weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine
Study officials:
References:
Clinical trial NCT06527950: Anterior Mandibular Region for Immediate Implant Placement
Official title: Analysis of the Anatomical Aspects of the Anterior Mandibular Region for Immediate Implant Placement: an Observational Cone Beam Computed Tomography Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Dental Implants
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-07-30
Enrollment: 103
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: CBCTs of teeth including the mandibular anterior zone showing central and lateral incisors and canines. The area of interest should include the complete view of roots, alveolar and basal bone related to the centrals, laterals and canines

Brief summary: Immediate implant placement has been proven to be a successful treatment modality, it is however considered a technique sensitive procedure, which mandates careful planning on basis of the recommended guidelines and thorough site assessment. The anatomical characteristics play a major role in the treatment planning, to determine that enough alveolar bone housing is available to accommodate the implant in the correct prosthetic-driven position and to avoid complications that may be caused by injury of the adjacent anatomical structures. There is scarcity in the literature regarding data on the anatomical features of the mandibular anterior zone in relevance to immediate implant planning. Analysis of the anatomical landmarks of the mandibular anterior region to determine the thickness of the labial and lingual alveolar bony plates, in addition to the bony socket configuration along with the labio-lingual socket dimension and relate them to immediate implant treatment planning


Eligibility criteria: Inclusion Criteria:

* CBCTs of teeth including the mandibular anterior zone showing central and lateral incisors and canines.

Exclusion Criteria:

* Radiographs of patients with malaligned teeth or with current or previous orthodontic treatment.
* Radiographs of patients with extensive bone loss due to infection or neoplasm in the area of interest

Primary outcomes:
measure: Labial bone thickness
timeFrame: 1 year
Secondary outcomes:
measure: Lingual bone thickness
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03196050: Telemonitoring of Geriatric Cancer Patients Using Handheld Devices
Official title: Telemonitoring of Geriatric Cancer Patients Using Handheld Devices (TeleGraPH)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cancer
Lead sponsor: Universitätsmedizin Mannheim
Sponsor class: OTHER
Collaborators: name: Hector-Stiftung
name: humediQ global GmbH, Grünwald
name: Vitaphone GmbH, Mannheim
First posted: 2017-06-22
Enrollment: 50
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: Cancer is becoming a chronic disease, with the requirement of a lifelong intake of cancer-controlling drugs. While young(er) patients may cope with this, geriatric cancer patients may require a more customized and tailored follow up.

Most elderly patients have multiple other diseases ("comorbidities") and, due to many other factors, may per se not tolerate or simply not follow anticancer therapies. This may not only impair quality of life (QoL), but on the long rung also the therapeutic outcome (survival).

Handheld devices provide a new reporting/communication tool for patients and health care providers. TeleGraPH will assess if these devices are a suitable communication modality in a cohort of geriatric cancer patients.


Eligibility criteria: Inclusion Criteria:

* Age \> 60 years
* Karnofsky Performance Status ≥ 70
* histologically confirmed malignant tumor (cancer)

Exclusion Criteria:

* concurrent severe and/or uncontrolled concomitant medical conditions
* Patients unwilling or unable to comply with using a handheld device

Primary outcomes:
measure: Device Adherence/Compliance
timeFrame: 1 Year
Secondary outcomes:
measure: Quality of Life
timeFrame: 1 Year
measure: Reliability of reports
timeFrame: 1 Year
Other outcomes:
Locations:
city: Mannheim
country: Germany
facility: Department of Radiotherapy University Hospital Mannheim
Study officials:
References:
citation: Buergy D, Siefert V, Neumaier C, Ganslandt T, Sperk E, Blessing M, Hesser J, Welzel G, Wenz F, Giordano FA. Prospective trial on telemonitoring of geriatric cancer patients using handheld devices. Strahlenther Onkol. 2020 Mar;196(3):205-212. doi: 10.1007/s00066-019-01548-0. Epub 2019 Nov 18.
Clinical trial NCT03474250: Trans-aortic Valve Replacement and Renal Infarction
Official title: Trans-catheter Aortic Valve Replacement and Renal Infarction Among Patients With Severe Aortic Stenosis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Renal Infarction
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2018-03-22
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients that will be undergoing trans-cather aortic valve replacement for severe symptomatic aortic stenosis

Brief summary: Kidney Magnetic Resonance assessment before and after undergoing transcatheter aortic valve replacement

Detailed description: Each patient will undergo Magnetic Resonance assessment of the kidneys before the TAVR. on the third to 7th day after the ATVR, a second MRI to the kidneys will be performed. we will assess the changes and new lesions between both MRI tests and will perform a qualitative and quantitative measurement.

Eligibility criteria: Inclusion Criteria:

* Severe symptomatic aortic stenosis
* Patient is able to lay down supine for 20 min (the time needed to perform the MRI) without any difficulties.

Exclusion Criteria:

* Patient is on chronic renal replacement therapy (Dialysis)
* Documented Thrombus in the left ventricle or left atria

Primary outcomes:
measure: New Renal Infarction
timeFrame: one year
Secondary outcomes:
measure: Hematuria
timeFrame: one year
measure: Elevation in Blood Pressure
timeFrame: one year
measure: Elevation in Plasma Renin Activity
timeFrame: one year
measure: Elevation in Aldosteron level
timeFrame: one year
Other outcomes:
Locations:
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
Study officials:
affiliation: Tel Aviv University
name: Arwa Younis, Doctor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05569850: Efficacy of an Antibacterial Toothpaste and Patients' Satisfaction
Official title: In Vivo Evaluation of Antibacterial Toothpaste Efficiency and Patients' Satisfaction: a Double-blind Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Caries
Gingivitis
Lead sponsor: University of Bologna
Sponsor class: OTHER
Collaborators: name: Unilever R&D
First posted: 2022-10-06
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The primary objective of this randomized controlled clinical trial (RCCT) will be to compare the efficacy in reducing the quantity of Streptococcus mutans (S. Mutans) in saliva of a recently introduced toothpaste compared to a commercially available toothpaste. The secondary outcomes will be to assess patients' impression of the toothpastes (in terms of taste, satisfaction etc.), and to investigate potential changes in dentin hypersensitivity, plaque formation and gingival inflammation.


Eligibility criteria: Inclusion Criteria:

1. Patients with minimum 20 teeth;
2. Good oral hygiene level (gingival bleeding index not exceeding 20%)
3. Patients willing to participate in the study and able to sign an informed consent

Exclusion Criteria:

1. Tooth anomalies (amelogenesis imperfecta, dentinogenesis imperfecta etc.);
2. Intrinsic stain (fluorosis);
3. Caries lesions;
4. Advanced periodontal disease (probing \>2, spontaneous gum bleeding, tooth mobility \>1);
5. Smokers;
6. Use of orthodontic devices;
7. Use of antibiotics in the last 3 months;
8. Use of antibacterial mouth rinses in the last 3 months;
9. Potential allergies;
10. Drug and alcohol abuse;

Primary outcomes:
measure: Bacterial Count of Streptococcus Mutans (S. Mutans)
timeFrame: 4 weeks
Secondary outcomes:
measure: Plaque Index
timeFrame: 4 weeks
measure: Gingival Index
timeFrame: 4 weeks
measure: Dentin Hypersensitivity
timeFrame: 4 weeks
measure: Tooth Colour
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Bologna
country: Italy
facility: DIBINEM
state: BO
Study officials:
References:
Clinical trial NCT02583750: Snooze Control: Sleep Duration & Glucose Metabolism
Official title: Snooze Control: The Effect of Sleep Deprivation on Glucose Metabolism
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Glucose Metabolism Disorders
Keywords: glucose metabolism
sleep deprivation
Lead sponsor: University of South Carolina
Sponsor class: OTHER
First posted: 2015-10-22
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This project investigated how glucose metabolism differs due to sleep deprivation for three consecutive nights as compared to sufficient sleep for three nights by examining concentrations of glucose, insulin, and other factors involved in glucose metabolism.

Detailed description: 16 participants were enrolled in the study (8 females, 8 males) aged 18-25 years. In order for the participants to qualify for the study, each had to wear a pedometer for a week before the study began to determine eligibility. Each participant came to the lab for an oral glucose tolerance test on a morning, following three nights when they were sleep deprived, and on another morning when they had three nights' sufficient sleep. The sequence of the oral glucose tolerance tests were randomly assigned. The sleep duration for participants was monitored by the readings of the sleep monitors that each participant wore. The oral glucose tolerance tests were performed after an overnight fast. A 20-gauge polyethylene catheter was placed in the antecubital vein for blood sampling. Blood samples were drawn once (0 min) before and 4 times (30, 60, 90, and 120 min) after a 75g glucose drink was consumed for the determination of plasma glucose, insulin, and concentrations of other factors. Each participant was told to continue their regular routine during the study period, including diet, caffeine usage, and exercise.

Eligibility criteria: Inclusion Criteria:

* healthy college-aged males and females
* being minimally active

Exclusion Criteria:

* average more than 15,000 steps a day
* major health issues such as heart disease, diabetes
* taking medication to help with sleep or using a sleeping device
* any type of sleep problem such as sleep apnea

Primary outcomes:
measure: Glucose concentrations during oral glucose tolerance test
timeFrame: two hours
Secondary outcomes:
Other outcomes:
Locations:
city: Columbia
country: United States
facility: Public Health Research Center University of South Carolina
state: South Carolina
Study officials:
affiliation: University of South Carolina
name: Xuewen Wang, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01651650: An Open Label Placebo Study to Assess the Inhalation Profile in Asthmatic Patients Using the Nexthaler® Dry Powder Inhaler (DPI) Device
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Asthma
Keywords: Asthma
PIF
Lead sponsor: Chiesi Farmaceutici S.p.A.
Sponsor class: INDUSTRY
First posted: 2012-07-27
Enrollment: 41
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Phase IIa, single-centre, open-label, single-arm study, to evaluate the inspiration profile through the NEXThaler® device in adult asthmatic patients with varying degrees of disease control.

Detailed description: The primary objective of this study is to assess the inspiratory flow profile through the NEXThaler® device in adult asthmatics with varying degrees of disease control.

The study plan foresees one visit at clinic. At Visit 1, after the signature of the informed consent form, the inclusion/exclusion criteria will be checked and the lung function parameters will be evaluated. If the subjects meet the inclusion/exclusion criteria, they will be instructed to use the NEXThaler®. The patients will subsequently inhale through the device and the inspiration profile will be measured.

A total of 40 asthmatic adults (≥18 years), 20 with controlled stable disease and 20 with partly controlled or uncontrolled disease according to GINA guidelines (2011), will be enrolled.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of controlled, partly controlled or uncontrolled asthma according to GINA guidelines (2011)
* A cooperative attitude and ability to use DPIs and to be trained in the proper use of the NEXThaler® as confirmed by the activation of the training device BAM

Exclusion Criteria:

* Significant seasonal variation in asthma or asthma occurring only during episodic exposure to an allergen or a chemical sensitizer
* History of near fatal asthma (e.g. brittle asthma, hospitalisation for asthma exacerbation in Intensive Care Unit)
* Diagnosis of restrictive lung disease
* Significant unstable medical history of and/or treatments for cardiac, renal, neurological, hepatic, endocrine diseases, or any laboratory abnormality indicative of a significant underlying condition, that may interfere with patient's safety, compliance, or study evaluations, according to the investigator's opinion.

Primary outcomes:
measure: Evaluation of inhalatory profile for 40 patients
timeFrame: One visit per patient (visit 1)
Secondary outcomes:
Other outcomes:
Locations:
city: Parma
country: Italy
facility: Clinica Pneumologica, AOU di Parma
Study officials:
affiliation: Clinica Pneumologica, AOU di Parma
name: Alfredo A. Chetta, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01181050: Efficacy of NNC0142-0002 in Subjects With Rheumatoid Arthritis (RA)
Official title: A Randomised, Single-dose, Double-blind, Placebo-controlled, Parallel-group Trial to Assess Clinical Efficacy of NNC0142-0002 in Subjects With Active Rheumatoid Arthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Inflammation
Rheumatoid Arthritis
Lead sponsor: Janssen Research & Development, LLC
Sponsor class: INDUSTRY
First posted: 2010-08-13
Enrollment: 63
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This trial is conducted in Europe. The aim of this trial is to evaluate the clinical efficacy of a single dose of NNC0142-0002 administered to subjects with active rheumatoid arthritis (RA).


Eligibility criteria: Inclusion Criteria:

* A diagnosis of RA meeting the American College of Rheumatology 1987 (ACR1987) criteria, obtained at least three months prior to dosing with the trial product
* Subjects with active RA having a Disease Activity Score (DAS28-CRP) of 4.5 or more, at least five tender and five swollen joints (can be the same), including one swollen wrist or at least two swollen ipsilateral metacarpophalangeal (MCP) joints (second to fifth)
* Concomitant treatment with methotrexate (MTX) (7.5-25 mg/week) for at least 12 weeks, with stable dose for at least 4 weeks prior to dosing
* Ability to be examined by Magnetic Resonance Imaging (MRI)
* Having failed no biologic therapies for RA and no more than two non-biologic disease modifying antirheumatic drugs

Exclusion Criteria:

* Chronic inflammatory autoimmune disease other than RA (rheumatoid arthritis)
* Any ongoing chronic or active infectious disease or microbial infection requiring systemic oral or intravenous treatment against infection within 1 month prior to trial start
* Body mass index (BMI) below or equal to 18 or above or equal to 40 kg/m\^2

Primary outcomes:
measure: Change in DAS28-CRP After 12 Weeks of Treatment
timeFrame: Week 0, Week 12
Secondary outcomes:
measure: Change in DAS28-CRP After 6 Weeks of Treatment.
timeFrame: Week 0, Week 6
measure: Change in DAS28-CRP After 24 Weeks of Treatment.
timeFrame: Week 0, Week 24
Other outcomes:
Locations:
city: Berlin
country: Germany
city: Moscow
country: Russian Federation
city: Kiev
country: Ukraine
Study officials:
affiliation: Novo Nordisk A/S
name: Global Clinical Registry (GCR, 1452)
role: STUDY_DIRECTOR
References:
Clinical trial NCT06816550: A Prospective Study of Pattern of Chronic Use of NSAIDS in Patients Admitted to Emergency Department in Alexandria Main University Hospital.
Official title: A Prospective Study of Pattern of Chronic Use of NSAIDS in Patients Admitted to Emergency Department in Alexandria Main University Hospital.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: NSAIDs Administration
Keywords: NSAIDS
chronic use
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2025-02-10
Enrollment: 350
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who are admitted to Emergency department in Alexandria main University Hospital during the study period

Brief summary: The goal of this observational study is to assess the pattern of chronic use of nonsteroidal anti inflammatory drugs in patients admitted to emergency department in Alexandria Main University Hospital. The main question it aims to answer is:

What is the prevalence of chronic use of nonsteroidal anti inflammatory drugs among patients admitted to emergency department in Alexandria Main University Hospital?

Detailed description: This is a prospective cross sectional study of pattern of chronic use of NSAIDS in patients admitted to emergency department in Alexandria Main University Hospital.

Three well trained emergency clinical pharmacists will start medication reconciliation process on admission by interviews with the patients or their care givers.

The study aims to assess the pattern of chronic use of NSAIDS and evaluate the patients' knowledge about doses, duration and adverse events and other use precautions .Finally to provide counseling service regarding NSAIDS medical information to patients admitted to emergency department in Alexandria Main University Hospital.

Eligibility criteria: Inclusion Criteria: all adults equal or more than 18 years -

Exclusion Criteria:Patients who cannot communicate or have no family members.

-

Primary outcomes:
measure: prevelence of chronic use of NSAIDS among total patients admitted to emergency department
timeFrame: two months from 1 March 2025 to 1 May 2025
Secondary outcomes:
measure: Percentage of patients who are already aware about NSAIDS chronic use adverse effects
timeFrame: one month
Other outcomes:
measure: Penrcentage of patients who have taken a counselling session about NSAIDS chronic use adverse effects
timeFrame: one month
Locations:
city: Alexandria
country: Egypt
facility: Alexandria Main University Hospital
Study officials:
References: