louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04952103: Real World Study of Diagnosis and First-line Treatment Among Patients With Cancer of Unknown Primary in China
Official title: Real World Study of Diagnosis and First-line Treatment Among Patients With Cancer of Unknown Primary in China
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cancer of Unknown Primary Site
Lead sponsor: Fudan University
Sponsor class: OTHER
First posted: 2021-07-07
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with cancer of unknown primary (CUP) and are gonging to receive the first-line therapy for CUP

Brief summary: This study is a prospective, real world study.The objective is to observe the diagnosis and first-line treatment of Chinese patients with cancer of unknown primary, and collect the clinicopathological characteristics, treatment outcomes, survival and other data of the patients.


Eligibility criteria: Inclusion Criteria:

* Had a diagnosis of cancer of unknown primary (CUP) after a standard evaluation .
* Prepared to receive first-line therapy for CUP

Exclusion Criteria:

* Patients who had previously received systemic therapy for CUP
* Previous history of other cancers, except cervix cancer or basal cell carcinoma of the skin that has been cured
* The investigator considered that there were contraindications to treatment or were not appropriate to participate in this study

Primary outcomes:
measure: Progression-free survival (PFS)
timeFrame: 8 months
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Fudan University Shanghai Cencer Center
state: Shanghai
Study officials:
References:
Clinical trial NCT02163603: A Trial on the Opportunity and Treatment of Residual Deformity After Reduction in Developmental Dislocation of the Hip
Official title: A Multi-center Study on the Opportunity and Treatment of Residual Deformity After Reduction in Developmental Dislocation of the Hip
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Developmental Dislocation of the Hip
Congenital Dislocation of Hip
Residual Deformity
Reduction
Lead sponsor: Guangzhou Women and Children's Medical Center
Sponsor class: OTHER
Collaborators: name: Tongji Hospital
name: Wuhan Union Hospital, China
name: Hunan Children's Hospital
name: Shenzhen Children's Hospital
name: Foshan Hospital of Traditional Chinese Medicine
name: Wuhan Women and Children's Medical Center
First posted: 2014-06-13
Enrollment: 2
Sex: ALL
Minimum age (years): 1
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The south of China

Brief summary: Developmental dislocation of the hip is a common disease in children, and its incidence in China is about 9 ‰.The pathological changes of it is complex. The reluxation , subluxation and residual deformity and other complications are relatively common after treatment. The X-ray appears great acetabular index and wide medial gap , small central-edge angle. As there is no effective methods for treating such complications , investigators conducted this trial to find and prove optimal intervention time and treatment programs.


Eligibility criteria: Inclusion Criteria:

* The inclusion criteria consists of patients with large acetabular index ,small central-edge angle after reduction in developmental dislocation of the hip

Exclusion Criteria:

* Age \>14 years
* Patients are complicated with mental, neurological disorders (such as hypoxic-ischemic encephalopathy, epilepsy and dementia) or significant barriers to growth.
* Patients are complicated with cerebral palsy, multiple joint contractures disease.
* Children are complicated with dysfunction of liver and kidney , blood disorders, immune deficiency disease and ECG abnormalities.
* Parents refused further treatment.

Primary outcomes:
measure: Early treatment can achieve good results in the residual deformity after reduction in developmental dislocation of the hip
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03919903: Parent's Knowledge, Attitude and Practices Towards Oral Health of Their Children With Primary Dentition: A Cross-sectional Study
Official title: Parent's Knowledge, Attitude and Practices Towards Oral Health of Their Children With Primary Dentition: A Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Oral Health Knowledge
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2019-04-18
Enrollment: 301
Sex: ALL
Minimum age (years): 1
Maximum age (years): 8
Standard ages: CHILD
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Parents of children with primary dentition

Brief summary: Study aims to assess Parents Knowledge, Attitude and Practices towards Oral Health of their Children with Primary Teeth.

Detailed description: Dental caries is a chronic slowly progressing localized destruction of dental hard tissues by the acidic products formed as result of carbohydrates fermentation by bacteria due to disturbance in equilibrium between tooth minerals and plaque products through time. (Trindade et al., 2014) It's a worldwide disease affecting all ages both sexes with different socioeconomic levels. Dental caries commonly affects children and adversely affects their quality of life and so their weight and growth if left untreated (Gokhale and Nuvvula, 2015). The environmental factor is a very valuable factor affecting dental caries especially the mother and the family as whole, the family habits are directly influencing their children (Suma G and Anisha P, 2017). As parents are the primary decision makers for children and their first role models, their oral health knowledge, attitude and practice as well as habits influence their children (Dikshit et al., 2018).

There is lack of data about parent's oral health knowledge, attitude and practice and their implications on their children in Egypt.

Acquiring information about oral health knowledge of parents, will help identifying those children who are at risk of dental caries consequently it will be possible to offer the proper preventive and curative measures for them.

So, we need to know the effect of oral health knowledge, attitude and practice (KAP) of parents on caries prevalence of their children.

Eligibility criteria: Inclusion Criteria:

* Healthy children and their parents.
* Children with primary dentition.

Exclusion Criteria:

* Parents refuse to participate.

Primary outcomes:
measure: Parents Oral Health Knowledge, Attitude and Practice (KAP)
timeFrame: one year
Secondary outcomes:
measure: Caries Prevalence in their children
timeFrame: one year
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Pediatric Dentistry and Dental public Health, Cairo University
Study officials:
References:
Clinical trial NCT06246903: INTER-PATHOLOGIST READER STUDY
Official title: INTER-PATHOLOGIST READER STUDY
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Nevi, Dysplastic
Lead sponsor: Orlucent, Inc
Sponsor class: INDUSTRY
First posted: 2024-02-07
Enrollment: 500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Previous consented subject\&#39;s scans from the Orlucent OMS002, SFI001 or SFI003 Studies and

Brief summary: This is a post study histology analysis from previously obtained pathology slides.

Detailed description: This is a post study histology analysis. Pathologists will use digital histology slide scans of suspicious nevus/nevi obtained from previously conducted studies to provide histopathology gradations of histological features as outlined in the Orlucent histology atlas (LBL0713 Histopathology Atlas for Grading of Dysplastic Nevi and DEF0713-1 Histopathology Definitions for LBL0713).

Eligibility criteria: Inclusion Criteria:

1. Histology scans must have been obtained from previous consented subjects that allows post study ad hoc analyses.
2. Histology scans must be available from the data collected from the Orlucent OMS002, SFI001 or SFI003 Studies and are of good quality.

Exclusion Criteria:

* NA

Primary outcomes:
measure: Study Success
timeFrame: 8 months
Secondary outcomes:
Other outcomes:
Locations:
city: Salt Lake City
country: United States
facility: University of Utah Hospital, Pathology
state: Utah
Study officials:
affiliation: Founder and President
name: Cathy Shachaf, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05213403: Innovative "Scoring System" in Breast Cancer Post Neoadiuvant Chemotherapy
Official title: Innovative "Scoring System" in Breast Cancer: a Valid Surgical Choice After Neoadjuvant Chemotherapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Early Breast Cancer
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2022-01-28
Enrollment: 255
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing neoadjuvant chemotherapy subsequently subjected to conservative surgery (Quadrantectomy/lumpectomy), Oncoplastic surgery second level or conservative mastectomy with breast reconstruction

Brief summary: Our aim is to create a Scoring System (SS) able of guaranteeing radical oncology by completely removing cancer and aesthetic outcomes in line with the needs or expectations of the patients that helps surgeons to decide the type of surgery in patients undergoing NACT.

Secondary outcome is to assess the ability of the score to avoid neoplastic relapses by evaluating:

* Loco-regional disease free-survival (LR-DFS): months between start of NACT and date of a neoplastic recurrence in residual mammary gland, in ipsilateral chest wall or in ipsilateral axilla.
* Distant disease-free survival (DDFS): months between start of NACT and date of onset of visceral or skeletal metastases.
* Overall survival (OS): months from the start of NACT to death or last follow-up.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing neoadjuvant chemotherapy
* Surgery: Breast conservative surgery; Oncoplastic surgery type II; Conservative mastactomy (nipple sparing - NSM or skin sparing - SSM)

Exclusion Criteria:

* lack of initial staging or restaging;
* previous or synchronous history of systemic malignant neoplasms.
* history of homo-or contralateral breast cancer.
* initial evidence of metastatic pathology or development of metastases during noeadjuvant chemotherapy (Stage IV)
* indication to modified radical mastectomy (MRM) without delayed reconstruction

Primary outcomes:
measure: Development of a new scoring system
timeFrame: 2016-2021
Secondary outcomes:
measure: Evaluation of outcome disease
timeFrame: 2016-2021
Other outcomes:
Locations:
Study officials:
affiliation: IRCCS Policlinico Agostino Gemelli - Roma
name: Gianluca Franceschini, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04559490: Baby Formula and Health
Official title: Formula - Understanding Nutrition (FUN)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pancreas Disease
Lead sponsor: University of Rochester
Sponsor class: OTHER
First posted: 2020-09-23
Enrollment: 22
Sex: ALL
Minimum age (years): 5
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Mothers and infants will be enrolled.

Brief summary: The purpose of this study is to learn about how different types of carbohydrates used in infant formula may affect a baby's intestines and pancreas.


Eligibility criteria: Inclusion Criteria:

* Mothers ≥ 19 years of age
* Singleton birth
* Healthy Infants
* Infant between 3-6 months at the time of visit and exclusively fed one of the formulas for a minimum of 3 months

Exclusion Criteria:

* Delivery before 35 weeks
* Infant birth weight \<2500g
* Infants exhibiting growth faltering (loss of more than 25 percentile points) between 1 month to the time of study visit for either weight or length.
* Infant medical or genetic indications that would impact normal feeding behavior, insulin signaling or growth patterns.
* Infant consumption of more than two servings of complementary foods per day before the study visit.

Primary outcomes:
measure: mean change in blood glucose
timeFrame: baseline to 1 hour
Secondary outcomes:
measure: mean endogenous insulin secretion
timeFrame: baseline to 1 hour
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Clinical Research Center of the University of Rochester Medical Center
state: New York
Study officials:
References:
Clinical trial NCT03241290: Assessement of the C-ARM ARCO FP-Rk521 S in Surgical Conventional Practice
Official title: Prospective Assessment of the Quality of the Image and the Usability of the C-ARM ARCO FP-Rk521S Used in Surgical Conventional Practice
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: C.Surgical Procedure
Keywords: C-arm
Medical Imaging Device
Radiological
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
Collaborators: name: Clinical Investigation Centre for Innovative Technology Network
First posted: 2017-08-07
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects who undergo surgery (orthopedic, urological or neurological surgery)

Brief summary: THALES-EVAQUAL study assesses the quality of the images generated by C-ARM ARCO FP-Rk521S and its ability to be used during surgery.

Detailed description: Expected performance of TED developped technology compared to current equipment (intensifier tube) represent a significant improvement; especially in term of image rendering, irradiation dose reduction and ergonomy.

THALES-EVAQUAL is a prospective,monocentric, unrandomized, and uncontrolled study which objective is to assess C-ARM ARCO FP-Rk521S in term of quality of image. It also evaluates its ability to be used during Orthopedic, neurological and neurological surgeries.

Patient included in the study will have a surgery during which C-ARM is used. This study doesn't modify the medical care of the patient.

After each surgery, a digital scale of image quality will be filled by the surgeon for each aquisition. Other feedback questionnaires regarding the suitability of the device and the satisfaction of the surgeon will also be completed.

Eligibility criteria: Inclusion Criteria:

* Subject having signed the non-objection form;
* Requiring one of the following surgical procedures:

  * Urology: soft ureteroscopy, uteroscopy, sacral neuromodulation, JJ sent placement.
  * Orthopedics: vertebroplasty, gamma nail placement, sacro-iliac screw fixation.
  * Neurology: spinal surgery

Exclusion Criteria:

* Subject who refuse to participate in the study;
* Who are under legal protection measure or unable to express their consent (guardianship, curatorship);
* Deprived of liberty by judicial or administrative decision.

Primary outcomes:
measure: Digital scale of image quality
timeFrame: up to 5 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Grenoble
country: France
facility: University Hospital, Grenoble
Study officials:
affiliation: University Hospital, Grenoble
name: Alexandre Moreau-Gaudry, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01520090: Egyptian Women Knowledge and Use of Different Contraceptive Methods
Official title: Egyptian Women Knowledge and Use of Different Contraceptive Methods
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Contraception
Keywords: contraception
family planning
egyptian
knowledge
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2012-01-27
Enrollment: 1200
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 51
Standard ages: ADULT
Accepts healthy volunteers: yes
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: egyptian women ,18 -51 years old Using a contraceptive method for at least 6 months continuously.

Brief summary: Starting from Jan 2012 for an interval of 4 months with minimum number of 1200 egyptian women will be asked to complete a questionairre to evaluate their knowledge of different contraceptive methods

Detailed description: PATIENTS AND METHODS

Sample size, Time of the study:

Starting from Jan 2012 for an interval of 4 months with minimum number of 1200women .

Type of the study:

Analytical crossectional study

Place of the study:

Ain Shams University Hospital, Gynecological outpatient clinic and Amireya primary care medical center (family planning clinic).

Statistical methodology:

SPSS program will be used for data analysis. Appropriate significance tests will be used according to type of data.

After an oral consent is taken from them, Women will be asked to complete a short written questionnaire that includes social data, reproductive information, and some questions about common contraceptive methods.

Testing readability and comprehension of the questionnaire will be done first by collecting 50 questionnaires and analyzing the data.

AIM OF THE WORK The aim of this study is to evaluate knowledge and use of different available contraceptive methods among women attending Ain Shams University maternity hospital in the gynecological outpatient clinic and Amireya primary care medical center (family planning clinic).

Eligibility criteria: Inclusion Criteria:

1. Age : 18 -51 years old
2. Using a contraceptive method for at least 6 months continuously.

Exclusion Criteria:

1. Infertile
2. Vaginal bleeding of unknown etiology.
3. Current pregnancy
4. Menopausal

Primary outcomes:
measure: knowledge of the different contraceptive methods
timeFrame: march 2012
Secondary outcomes:
measure: correct use of different contraceptive methods
timeFrame: march 2012
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University Maternity Hospital Out-Patient Clinic
Study officials:
affiliation: Ain Shams University
name: rania m abdelmoez, M.B., B.CH.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03961490: Contribution of Image Fusion in Percutaneous Left Atrial Occlusion procédures (Fusion Image)
Official title: Contribution of Image Fusion in Percutaneous Left Atrial Occlusion Procedures
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Atrial Fibrillation
Lead sponsor: Nantes University Hospital
Sponsor class: OTHER
First posted: 2019-05-23
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: This is an elderly population with multiple co-morbidities (hypertension, renal failure, diabetes, etc.), with a major thromboembolic and haemorrhagic risk, and with a formal contraindication to anticoagulant therapy.

Brief summary: Atrial fibrillation is the most common rhythm disorder, affecting 2 to 3 percent of the population. One of the major complications is the occurrence of thromboembolic events, the thromboembolic risk can be predicted by the ChadsVasc score. Anticoagulant treatment is therefore almost always indicated, however, in view of the target population, anticoagulant treatment is sometimes contraindicated, justifying the appearance of alternative treatment such as occlusion of the left auricle by surgical or percutaneous means, with the placement of a prosthesis in the left auricle.

Image fusion is a new imaging technique aimed at improving the spatial view of 2D images (made during a catheterization session) by repositioning in real time a 3D model obtained by reconstruction from scanner images of the structure of interest. Once the model has been redesigned, it follows all the consequences that the hemodynamicist wants to take and thus guides the gesture as well as possible.

The purpose of this project is to evaluate the contribution of image fusion to per cutaneous occlusion procedures of the left atrium. This contribution will be evaluated by comparing the procedure time, the irradiation time, the amount of contrast material used between the procedures performed with the image fusion technique and without this new technique.


Eligibility criteria: Inclusion Criteria:

* Major patient
* Patient with a collegially selected indication of FAG
* Patient willing to participate in the study

Exclusion Criteria:

* Minors, adults under guardianship and protected persons
* Presence of contraindications to the procedure, including the presence of a thrombus in the left atrium
* Procedure combined with another percutaneous gesture at the same time

Primary outcomes:
measure: evaluate the contribution of image fusion to reduce patient irradiation with measurement of the amount of irradiation of the procedure
timeFrame: 3 years
measure: evaluate the contribution of image fusion to reduce patient irradiation with measurement of the amount of irradiation of the procedure
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Nantes
country: France
facility: Professeur Patrice Guerin
Study officials:
References:
Clinical trial NCT06842290: Effect of Botulinum Toxin a Injection in Treatment of Recession RT1 and RT2
Official title: Effect of Botulinum Toxin -A Injection in Mentalis Muscle with Coronally Advanced Flap and De-epithelized Free Gingival Graft in Treatment of RT1 , RT2 Gingival Recession _Randomized Control Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Gingival Recession
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-02-24
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this study type: clinical trial\] is to learn the effect of Botulinum Toxin _A injection in treatment of RT1andRT2 Gingival recession in lower anterior teeth .

Primary outcome is keratinzed tissue width. Researchers will compare Coronally Advanced flap with De-epithelized free gingival graft and Botulinum toxin-A injection in Mentalis muscle with coronally advanced flap with De-epithelized free gingival graft alone .

The outcome will be measured at baseline, after 3 months and after 6 mobths _medical history

* 3 mm horizontal incisions, then two vertical incisions
* deepitheliztion of anatomical papillae
* superficial and deep incisions
* harvesting DFGG
* Suturing
* BOTOX injection


Eligibility criteria: Inclusion Criteria:

* Single or multiple RT1, RT2 GR patient
* patients ≥18 years
* systemically healthy, full mouth plaque score, full mouth bleeding score ≤ 15% after phase I therapy
* clinical indication and/or patient request for recession coverage
* well motivated patients, maintaining oral hygiene throughout study

Exclusion Criteria:

* Pregnant or lactating women
* Smokers' patients
* Teeth with cervical restorations/abrasion.
* Patients had a systemic condition affect blood components and healing

Primary outcomes:
measure: Keratinized tissue width
timeFrame: Measured at baseline ,3months ,6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: