Clinical trial NCT05701579: Assessment of Anterior Cruciate Ligament (ACL) Degeneratio Mucosa Treatment
Official title: Assessment of Anterior Cruciate Ligament (ACL) Degeneratio Mucosa Treatment
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries
Lead sponsor: Artromedical Konrad Malinowski Clinic
Sponsor class: OTHER
First posted: 2023-01-27
Enrollment: 10
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with ACL degeneratio mucosa decided to undergo a surgical treatment

Brief summary: Anterior Cruciate Ligament (ACL) Degeneratio Mucosa is a condition resulting from mucoid degeneration of ACL. Exact etiology is unknown, however ACL Degeneratio Mucosa impairs everyday functioning. In the literature there were some reports of treatment by ACL excision and subsequent reconstruction, however such treatment brings risk of deteriorated function. In this study the investigator will evaluate the technique of ACL "decompression" by the means of longitudinal incisions and evacuation of extrafibrous mucoid tissue.


Eligibility criteria: Inclusion Criteria:

* patients with ACL degeneratio mucosa decided to undergo a surgical treatment
* range of motion impairment caused by mucoid or cystic changes in ACL confirmed by MRI

Exclusion Criteria:

* non-adherence to the study protocol
* active knee inflammation
* range of motion impairment due to other extra- and intra-articular reasons

Primary outcomes:
measure: Range of motion
timeFrame: At the 12 month of the follow-up
measure: Range of motion
timeFrame: At the 24 month of the follow-up
measure: Knee anterior translatory stability
timeFrame: At the 12 month of the follow-up
measure: Knee anterior translatory stability
timeFrame: At the 24 month of the follow-up
measure: Knee anterolateral rotational stability
timeFrame: At the 24 month of the follow-up
Secondary outcomes:
measure: The functional assessment with the The International Knee Documentation Committee Questionnaire (IKDC)
timeFrame: At the 12 month of the follow-up
measure: The functional assessment with the The International Knee Documentation Committee Questionnaire (IKDC)
timeFrame: At the 24 month of the follow-up
measure: The functional assessment with the Knee injury and Osteoarthritis Outcome Score (KOOS)
timeFrame: At the 12 month of the follow-up
measure: The functional assessment with the Knee injury and Osteoarthritis Outcome Score (KOOS)
timeFrame: At the 24 month of the follow-up
Other outcomes:
Locations:
city: Bełchatów
country: Poland
facility: Artromedical Orthopaedic Clinic
state: Łódzkie
Study officials:
affiliation: Artromedical Orthopaedic Clinic, Bełchatów, Poland
name: Konrad Malinowski, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gersing AS, Schwaiger BJ, Nevitt MC, Joseph GB, Feuerriegel G, Jungmann PM, Guimaraes JB, Facchetti L, McCulloch CE, Makowski MR, Link TM. Anterior cruciate ligament abnormalities are associated with accelerated progression of knee joint degeneration in knees with and without structural knee joint abnormalities: 96-month data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2021 Jul;29(7):995-1005. doi: 10.1016/j.joca.2021.03.011. Epub 2021 Mar 26.
citation: Lintz F, Pujol N, Boisrenoult P, Bargoin K, Beaufils P, Dejour D. Anterior cruciate ligament mucoid degeneration: a review of the literature and management guidelines. Knee Surg Sports Traumatol Arthrosc. 2011 Aug;19(8):1326-33. doi: 10.1007/s00167-011-1433-0. Epub 2011 Feb 18.
citation: Sweed T, Mussa M, El-Bakoury A, Geutjens G, Metcalfe A. Management of mucoid degeneration of the anterior cruciate ligament: a systematic review. Knee Surg Relat Res. 2021 Aug 21;33(1):26. doi: 10.1186/s43019-021-00110-6.
citation: Lee JW, Ahn JT, Gwak HG, Lee SH. Clinical Outcomes of Arthroscopic Notchplasty and Partial Resection for Mucoid Degeneration of the Anterior Cruciate Ligament. J Clin Med. 2021 Jan 16;10(2):315. doi: 10.3390/jcm10020315.