louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05671523: Effect Of Dry Needling On Quality Of Life In Patients With Trigger Fingers
Official title: Effect Of Dry Needling On Quality Of Life In Patients With Trigger Fingers. Randomized Controlled Trail
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Trigger Finger Disorder
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-01-04
Enrollment: 40
Sex: ALL
Minimum age (years): 45
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will be conducted to investigate the effect of dry needling on quality of life in patients with trigger finger

Detailed description: Trigger finger (TF) is one of the most prevalent causes of hand disability and is a common cause of referral to orthopedic clinics. Trigger finger is tenosynovitis of the flexor sheaths that typically occurs in the 4th finger and thumb as a result of repetitive use. The incidence of TF is 28:100,000 per year or lifetime risk of 2.6% in the general population. It has the highest incidence being between 52 and 62 years more in women (75%). Thumb and fourth digit (ring finger) are the most commonly affected fingers.

Dry needling (DN) is a relatively new technique used by physical therapists to treat myofascial trigger points (MTrPs) and various pain syndromes. Dry needling is defined as a "skilled intervention using a thin filiform needle to penetrate the skin that stimulates myofascial TrPs, muscles, and connective tissue for the treatment of musculoskeletal pain disorders. DN has analgesic and anti-inflammatory effects, it is commonly used to relieve pain and reduce inflammation.

Eligibility criteria: Inclusion Criteria:

* 40 patients all have trigger fingers lasting at least 4 weeks.
* Both gender will be included
* Age of patients will be 45-75 years old
* Pain and tenderness at the position of A1 pulley.
* Nodule palpation, pain, and discomfort when flexing and extending the finger, presence of a clicking sound at the time of flexion or extension of the finger, snapping or locking of the finger.
* Willing and able to complete study procedures.

Exclusion Criteria:

* Participants with diabetes mellitus.
* History of trauma, and rheumatoid arthritis.
* Dialysis treatment.
* fingers with a history of local gouty/pyogenic disease.
* Major hand trauma and fear of needles.
* Any contraindication for deep dry needling such as anticoagulants, infections, bleeding, or psychotic conditions tumors, calcium deposits, or severe osteoarthritis.

Primary outcomes:
measure: Life quality
timeFrame: up to five weeks
measure: Severity of pain
timeFrame: up to five weeks
measure: Hand grip strength
timeFrame: up to five weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Damanhūr
country: Egypt
facility: Damanhour teaching hospital
Study officials:
affiliation: Damanhour Teaching Hospital
name: Eman Em El halawany
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04818723: Role of Montelukast in Preventing Relapse in Childhood Idiopathic Nephrotic Syndrome
Official title: Role of Montelukast in Preventing Relapse in Childhood Idiopathic Nephrotic Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nephrotic Syndrome
Keywords: Leukotriene antagonists
Nephrotic syndrome
Steroid
Lead sponsor: Nishtar Medical University
Sponsor class: OTHER
First posted: 2021-03-26
Enrollment: 106
Sex: ALL
Minimum age (years): 1
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: During the study period, adopting non-probability consecutive sampling method, patients were assigned into two groups; 53 in Case Group (given montelukast 5mg at bed time) and 53 in Control Group (given no montelukast).
Primary purpose: TREATMENT

Brief summary: The investigators planned this research to elucidate if there is any efficacy of montelukast, a leukotriene receptor antagonist, in steroid sensitive childhood onset NS to help prevent relapses. This study was done to know the role of leukotriene receptor antagonist (LTRA) montelukast in preventing relapses in idiopathic childhood nephrotic syndrome (NS)

Detailed description: A quasi-experimental study, done at Department of Pediatric Nephrology at the Children's Hospital \& the Institute of Child Health, Multan. A total of 96 patients aged 1-10 years with steroid sensitive Idiopathic NS were assigned into two groups (48 patients in each group). The case group received montelukast 5mg daily at bed time while the control group was not given montelukast. Steroid treatment protocol was the same for the two groups as per institutional guidelines. Patients were monitored and followed for the response to treatment and evidence of relapse over the study period (minimum 12 months).

Eligibility criteria: Inclusion Criteria:A total of 106 children aged 1-10 years with idiopathic nephrotic syndrome were enrolled

-

Exclusion Criteria: - Patients having Steroid resistant nephrotic syndrome (SRNS) or those having nephrotic syndrome with atypical features or Secondary cause were excluded.

Primary outcomes:
measure: Prevention of relapse in idiopathic childhood nephrotic syndrome
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Multan
country: Pakistan
facility: Department of Pediatric Nephrology, The Children's Hospital and Institute of Child Health
state: PPunjab
Study officials:
References:
Clinical trial NCT06916923: Dysfunctional Breathing, Exercise Capacity, and Balance in Hypertension
Official title: Relationship Between Dysfunctional Breathing, Exercise Capacity, and Balance in Patients With Hypertension: A Prospective Cross-Sectional Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Dysfunctional Breathing
Arterial Hypertension
Exercise Capacity
Balance
Lead sponsor: Istinye University
Sponsor class: OTHER
First posted: 2025-04-08
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The study population will consist of adults aged 18 to 70 years who have been clinically diagnosed with arterial hypertension and have been under follow-up for at least six months. All participants must have a Nijmegen Questionnaire score of 23 or higher, indicating a probable presence of dysfunctional breathing. Individuals must be willing to voluntarily participate in the study. Participants with recent medication changes (within the past month) or with unstable metabolic diseases will be excluded.

Brief summary: This prospective cross-sectional study aims to investigate the relationship between dysfunctional breathing (DB), exercise capacity, and balance in patients with arterial hypertension (HT). DB is characterized by abnormal breathing patterns and is associated with symptoms such as dyspnea and inefficient ventilation, regardless of the presence of organic respiratory disease. Hypertension may further exacerbate these symptoms and contribute to impaired exercise performance and postural balance. The study will assess DB using the Nijmegen Questionnaire, along with anthropometric measurements, balance tests, and functional exercise capacity evaluations. Findings may contribute to better understanding of respiratory dysfunctions in hypertensive individuals and their impact on physical performance.


Eligibility criteria: Inclusion Criteria:

* Aged between 18 and 70 years
* Diagnosed with hypertension and under follow-up for at least 6 months
* Willing to participate in the study voluntarily
* Nijmegen Questionnaire score of 23 or above

Exclusion Criteria:

* Medication change within the last month prior to study enrollment
* Presence of unstable metabolic disease

Primary outcomes:
measure: Assessment of Dysfunctional Breathing Level
timeFrame: At baseline
measure: Assessment of Balance-I
timeFrame: At baseline
measure: Assessment of Balance-II
timeFrame: At baseline
measure: Neck Circumference Measurements
timeFrame: At baseline
measure: Waist Circumference Measurement
timeFrame: At baseline
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Istınye University
Study officials:
affiliation: Istinye University
name: Kabasakal
role: STUDY_CHAIR
References:
Clinical trial NCT03708523: Next Day Growth Hormone Predicting Pituitary Function After Adenomectomy
Official title: Next Day Early Morning Growth Hormone as Predictor of Pituitary Function After Transsphenoidal Adenomectomy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hypopituitarism
Keywords: Hypopituitarism,Pituitary function
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2018-10-17
Enrollment: 400
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who had been treated with TSA were enrolled.

Brief summary: This study tried to highlight the predictive value of the morning postoperative cortisol levels, which can act as the prognosis value of the postoperative pituitary function, providing future medication advices for improving patients' safety of drugs.

Detailed description: Transsphenoidal adenomectomy usually accompanied by the failure or recovery of the pituitary gland, which usually causing further hypopituitarism and hormone recovery. In order to prevent the potential applications of adrenal cortical malfunction after the surgery, many medical centers will use glucocorticoid supplements during the perioperative period care. However, this treatment might expose the normal hypothalamic-pituitary-adrenal (HPA) axis function patients into potential threats after the treatment of glucocorticoid supplements, such as bone loss, hypertension, emotional distress, and weight gain. To avoid unnecessary supply of glucocorticoids, the key question is to monitor the pituitary function. Thus, in this study we try to predict the morning postoperative cortisol levels, for further prediction of the postoperative pituitary function. To do so, we will review the retrospective charts of transsphenoidal adenomectomied patients from January, 2013 to April, 2018 in the NTUH Taipei. Use statistical methods analyzing all sorts of medical reports, including perioperative hormone thresholds.This study tried to highlight the predictive value of the morning postoperative cortisol levels, which can act as the prognosis value of the postoperative pituitary function, providing future medication advices for improving patients' safety of drugs.

Eligibility criteria: Inclusion:

Patients who had been treated with TSA were enrolled.

Exclusion:

1. Hypopituitarism preoperatively.
2. Acromegaly
3. Multiple operations
4. Incomplete hormone data or loss of follow-up

Primary outcomes:
measure: Next Day Early Morning Growth Hormone as Predictor of Pituitary Function After Transsphenoidal Adenomectomy
timeFrame: 2 days
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei city
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: Fon-Yih Tsuang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06480123: Stem Cell Derived Exome for Treatment of Diabetic Foot
Official title: Skin Drug Prepared From Stem Cell Derived Exome for Treatment of Diabetic Foot: a Phase II Clinical Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE1
PHASE2
Conditions: Diabetic Foot
Stem Cell
Keywords: Diabetic foot
Stem cell
Exome
Skin drug
Lead sponsor: Second Affiliated Hospital of Guangzhou Medical University
Sponsor class: OTHER
First posted: 2024-06-28
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This trial is designed to investigate the safety and efficacy of patients with diabetic foot by using stem cell derived exome.

Detailed description: It is estimated that about 150 million people are suffering diabetes mellitus, of whom more than 15% will develop foot ulcers or gangrene at some times, so called diabetic foot. The diabetic foot is very difficult to cure by traditional approaches.

This phase I clinical trial is designed to assess the safety and theraputical benefit of the stem cell derived exome.

Eligibility criteria: Inclusion Criteria:

1. Clinical diagnosis of diabetic foot.
2. Signed informed consent before recruiting.
3. Age above 18 years or less than 90 years.
4. ECOG score \< 4
5. Tolerable coagulation function or reversible coagulation disorders
6. Laboratory examination test within 7 days prior to procedure: WBC≥3.0×10E9/L; Hb≥90g/L； PLT ≥50×10E9/L；INR \< 2.3 or PT \< 6 seconds above control；Cr ≤ 145.5 umul/L；Albumin \> 28 g/L；Total bilirubin \< 51 μmol/L
7. Willing and able to comply with scheduled visits, treatment plan and laboratory tests.

Exclusion Criteria:

1. Patients participated in clinical trials of equipment or drugs (signed informed consent) within 4 weeks;
2. Patients accompany by ascites, hepatic encephalopathy and esophageal and gastric varices bleeding;
3. Any serious accompanying disease, which is expected to have an unknown, impact on the prognosis, include heart disease, inadequately controlled diabetes and psychiatric disorders;
4. Patients have poor compliance.
5. Allergic to the skin drug;
6. Any agents which could affect the absorption or pharmacokinetics of the study drugs
7. Other conditions that investigator decides not suitable for the trial.

Primary outcomes:
measure: Safety of the treatment
timeFrame: Six months
measure: Efficacy of the treatment
timeFrame: Six months
Secondary outcomes:
measure: Duration of remission (DOR)
timeFrame: 5 years
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: The Second Affiliated Hospital of Guangzhou Medical University
state: Guangdong
Study officials:
affiliation: Second Affiliated Hospital of Guangzhou Medical University
name: Zhenfeng Zhang, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01687023: A Wearable System to Monitor Tai Chi Practice
Official title: A Wearable System to Monitor Tai Chi Practice
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: Tai Chi
Wearable sensors
Movement
Lead sponsor: Spaulding Rehabilitation Hospital
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2012-09-18
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Healthy Tai Chi practitioners in a wide range of proficiency

Brief summary: The goal of this research study is to show that features derived from data gathered using SHIMMER wearable sensor platform can capture adherence and proficiency in the performance of exercises that are part of Tai Chi interventions.


Eligibility criteria: Inclusion Criteria:

* Young style Tai Chi practitioners

Exclusion Criteria:

* Any movement impairment that will impede Tai Chi movements performance

Primary outcomes:
measure: Biomarkers of adherence and proficiency
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Spaulding Rehabilitation Hospital Boston
state: Massachusetts
Study officials:
References:
Clinical trial NCT05460923: Pelvic Neuromuscular Facilitation and Swiss Ball Exercises on Trunk Control in Children With Diaplegic CP
Official title: Comparison of Pelvic Neuromuscular Facilitation and Swiss Ball Exercises on Trunk Control in Children With Diaplegic Cerebral Palsy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cerebral Palsy
Keywords: Cerebral Palsy, Trunk Control Training, Proprioceptive Neuromuscular Facilitation Approach, Swiss ball, Trunk Control Measurement Scale.
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2022-07-15
Enrollment: 32
Sex: ALL
Minimum age (years): 5
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Cerebral palsy is an umbrella term that covers a group of non-progressive motor impairment syndromes that are associated with abnormalities in the brain particularly during the early stages of its development. CP usually involves a number of musculoskeletal and neurological problems they include spasticity, contractures, dystonia, abnormal growth, poor trunk control, and poor balance. Poor trunk control leads to a disturbance in activities of daily living along with postural issues. PNF techniques and Swiss ball exercises target the trunk muscles by stimulating the proprioceptors and by allowing maximum resistance to them respectively. The aim of the study is to do a comparison of Pelvic neuromuscular facilitation techniques and Swiss ball exercises in improving trunk control in children with diplegic cerebral palsy.

Detailed description: The studies conducted in the past were focused on finding out the effect of proprioceptive neuromuscular facilitation techniques on the lower extremities of children suffering from diplegic cerebral palsy. The effects of PNF on trunk control the children suffering from diplegic CP are nearly minimal. In addition to PNF, the literature shows that studies have been conducted to find the effects of Swiss ball training exercise on trunk control of the post-stroke patients however there is very little research on the effects of Swiss ball training in children suffering from diplegic CP. Even if the studies are conducted the time duration of the studies are not enough to gain the maximum outcomes.

Eligibility criteria: Inclusion Criteria:

* Patients with no trunk control
* Age between 5-12 years
* Patients with diplegia

Exclusion Criteria:

* Patients with Cognitive impairment
* Patients with comorbidities
* Patients who are unable to follow instructions

Primary outcomes:
measure: Trunk Control Measurement Scale
timeFrame: 8th week
measure: GMFC
timeFrame: 8th week
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: International Therapy Services Center
state: Punjab
city: Lahore
country: Pakistan
facility: Rising Sun Institute
state: Punjab
Study officials:
affiliation: Riphah International University
name: Wajiha Shahid, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00005323: Epidemiology of Persistent Pulmonary Hypertension of the Newborn - SCOR in Lung Biology and Diseases in Infants and Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Diseases
Cardiovascular Diseases
Defect, Congenital Heart
Heart Diseases
Persistent Fetal Circulation Syndrome
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Sponsor class: NIH
First posted: 2000-05-26
Sex: MALE
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: To conduct an epidemiologic study of persistent pulmonary hypertension of the newborn ( PPHN) infant.

Detailed description: BACKGROUND:

The study on the epidemiology of persistent pulmonary hypertension of the newborn (PPHN) was a subproject within a Specialized Center of Research (SCOR) in Lung Biology and Diseases in Infants and Children. The SCOR and its subproject were awarded in December, 1991. Dollars were estimated at 20 percent of total center dollars.

DESIGN NARRATIVE:

Data from a previous study of PPHN were analyzed. The objectives were to: identify the effects of a variety of potentially adverse prenatal exposures from interview data; formulate multi-variate models of risk of PPHN to determine if smoking or use of prostaglandin inhibitors increased the risk of PPHN; explore associations of PPHN with history of illicit drug use and maternal hypoxia; examine the relationships of postnatal care and perinatal risk factors on the incidence and outcome of PPHN; test the relationships of PPHN to the biochemical presence of nicotine and drugs in neonatal urine.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Eligibility criteria: No eligibility criteria

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Derkach IuS, Osherovich AM, Miasnenko AM. [Organization of the equipment and public health measures in virological laboratories of epidemiological health stations]. Lab Delo. 1984;(6):374-7. No abstract available. Russian.
citation: Christou H, Adatia I, Van Marter LJ, Kane JW, Thompson JE, Stark AR, Wessel DL, Kourembanas S. Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5'-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension. J Pediatr. 1997 Apr;130(4):603-11. doi: 10.1016/s0022-3476(97)70245-2.
Clinical trial NCT05449223: Urdu Version of Frenchay Activities Index: Reliability and Validity Study
Official title: Evaluation of Reliability and Validity of Urdu Version of the Frenchay Activities Index in Pakistani Geriatric Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Activity, Motor
Keywords: Frenchay Activities Index
Urdu Version
Activities of Daily Living
Validity
Reliability
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2022-07-08
Enrollment: 75
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Elderly people, especially those of the advanced ages having issue in performing in activities of daily living

Brief summary: In this study, we will observe the reliability and validity of frenchay activities index and barthel index in urdu language in geriatric population of Pakistan.

Detailed description: The aim of study is to translate and culturally adapt Frenchay Activities Index and Bathel Index into Urdu language and secondly to investigate the reliability and validity of Frenchay Activities Index and Barthel Index in geriatric population of Pakistan. This study will be cross sectional survey study in which convenience sampling technique will be used.

The results of study will help to know the validity and reliability of Frenchay Activities Index and Barthel Index in Urdu version with Activities of Daily Livings impairments in geriatric population of Pakistan. The reliability of the questionnaire will be checked through internal consistency and test-retest methods. internal consistency will be analyzed with Cronbach's alpha value. Test-retest reliability will be assessed using an intra-class correlation coefficient with 75 patients.

Eligibility criteria: Inclusion Criteria:

* 65 years old and older
* be able to read Urdu
* be living in Pakistan for more than 5 years
* have minimal cognitive impairment with Mini-Mental State Examination
* have no significant muscle, joint, or neurologic conditions such as stroke, or Parkinson's disease.

Exclusion Criteria:

* inability to understand to follow the instructions of Frenchay Activities Index and Barthel Index
* experience with the Frenchay Activities Index and Bathel Index in the last 6 months
* acute illness or fracture in the lower extremities

Primary outcomes:
measure: Frenchay activities index
timeFrame: 12th Week
measure: Barthel Index
timeFrame: 12th Week
Secondary outcomes:
Other outcomes:
Locations:
city: Faisalābad
country: Pakistan
facility: Riphah International University
state: Punjab
Study officials:
affiliation: Riphah International University
name: Muhammed Kashif
role: STUDY_CHAIR
References: