louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06957210: Post-Traumatic Growth Following Eye Movement Desensitization and Reprocessing Therapy Versus SSRIs in Patients With Post-Traumatic Stress Disorder
Official title: Post-Traumatic Growth Following Eye Movement Desensitization and Reprocessing Therapy Versus SSRIs in Patients With Post-Traumatic Stress Disorder: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: PTSD - Post Traumatic Stress Disorder
Keywords: PTSD
Post-traumatic Stress Disorder
Post-traumatic Growth
EMDR
Eye Movement Desensitization and Reprocessing
Lead sponsor: Combined Military Hospital Nowshera
Sponsor class: OTHER_GOV
First posted: 2025-05-04
Enrollment: 130
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This randomized controlled trial investigates the comparative effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy and selective serotonin reuptake inhibitors (SSRIs) in fostering post-traumatic growth among patients diagnosed with post-traumatic stress disorder (PTSD). Participants will be randomized to receive either EMDR therapy or standard SSRI pharmacotherapy. The primary objective is to evaluate the extent of psychological growth and recovery achieved through each intervention, aiming to guide future therapeutic strategies for PTSD.


Eligibility criteria: Inclusion Criteria:

Clinical diagnosis of Post-Traumatic Stress Disorder (PTSD) based on DSM-5 criteria

Willingness to participate and provide informed consent

Ability to comply with study procedures

Exclusion Criteria:

Current diagnosis of psychotic disorder, bipolar disorder, or severe major depressive episode with psychotic features

Active substance use disorder within the past 6 months

Severe cognitive impairment or inability to complete study assessments

Primary outcomes:
measure: Post-Traumatic Growth (PTG) measured by Post-Traumatic Growth Inventory (PTGI)
timeFrame: 6 weeks
Secondary outcomes:
measure: PTSD symptom severity measured by PTSD Checklist
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Nowshera
country: Pakistan
facility: Combined Military Hospital
state: KPK
city: Nowshera
country: Pakistan
facility: Department of Psychiatry, Combined Military Hospital Nowshera
state: KPK
Study officials:
References:
Clinical trial NCT04173910: Carotid Artery Analysis During an LPEC Manoeuvre
Official title: Effect of the Left Paratracheal Compression of the Cervical Esophagus and the Sellick Manoeuvre on the Compressibility of the Carotid Artery and Its Possible Effects on the Vascular Flow
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carotid Occlusion
Lead sponsor: University of Liege
Sponsor class: OTHER
First posted: 2019-11-22
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults

Brief summary: Verify in ultrasound the impact of a Sellick and LPEC manoeuvre in terms of compression of the carotid artery and decrease in vascular flow.


Eligibility criteria: Inclusion Criteria:

* Adults Volunteers

Exclusion Criteria:

* pregnant women
* people with carotid artery defects
* people with an anomaly in the oropharyngeal massif

Primary outcomes:
measure: Compression of the carotid artery during an esophageal compression manoeuvre
timeFrame: through study completion, an average of 1 month
measure: Vascular flow of the carotid artery during an esophageal compression manoeuvre
timeFrame: through study completion, an average of 1 month
Secondary outcomes:
measure: Measurement of the force to be applied to compress the esophagus without compressing the carotid artery
timeFrame: through study completion, an average of 1 month
Other outcomes:
Locations:
city: Liège
country: Belgium
facility: Javillier
Study officials:
References:
Clinical trial NCT05242510: Evaluation of Exotropia After Patching the Eye or After Prism Adaptation
Official title: Divergence Excess/Simulated Divergence Excess Exotropia (DESDEE)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Exotropia
Lead sponsor: University of Rochester
Sponsor class: OTHER
First posted: 2022-02-16
Enrollment: 1
Sex: ALL
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study intends to determine the number and percent of subjects initially diagnosed with divergence excess exotropia which would be reclassified as simulated divergence excess exotropia if tested after 24 hours of monocular occlusion (patching) or after prism adaptation for the distance angle.


Eligibility criteria: Inclusion Criteria:

* Diagnosed with divergence excess exotropia according to standard criteria (see Study Procedures for specifics)
* No prior strabismus surgery
* Able to cooperate with testing (by examiner determination)
* Neurologically normal except for strabismus (ADHD and autism spectrum are not exclusion criteria as long as the subject can cooperate for necessary testing)
* Not amblyopic at the time of enrollment (best-corrected visual acuity in both eyes of 20/40 or better)
* Under 18 years of age. There is no lower age limit as long as the subject can cooperate for the required testing.
* No diagnosis of dissociated vertical deviation

Exclusion Criteria:

* No diagnosis of divergence excess exotropia according to standard criteria (see Study Procedures for specifics)
* Prior strabismus surgery
* Unable to cooperate with testing (by examiner determination)
* Diagnosed with a neurological disorder (ADHD and autism spectrum are not exclusion criteria as long as the subject can cooperate for necessary testing)
* Best-corrected visual acuity in either eye worse than 20/40
* 18 years of age or older
* Diagnosed with dissociated vertical deviation

Primary outcomes:
measure: Percent of participants reclassified as divergence excess exotropia
timeFrame: 2 weeks
measure: Percent of participants reclassified as simulated divergence excess exotropia
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: University of California Los Angeles
state: California
city: Boston
country: United States
facility: Harvard University
state: Massachusetts
city: Buffalo
country: United States
facility: Ross Eye Institute
state: New York
city: Rochester
country: United States
facility: University of Rochester Medical Center
state: New York
city: Pittsburgh
country: United States
facility: University of Pittsburgh
state: Pennsylvania
city: Kingston
country: Canada
facility: Queen's University
state: Ontario
city: Hyderabad
country: India
facility: LV Prasad Eye Institute
city: Rishon LeZion
country: Israel
facility: Shamir Medical Center
state: Central
city: Milan
country: Italy
facility: University of Milan
Study officials:
References:
Clinical trial NCT06498310: Retrospective Study of Invasive Fungal Infections With Filamentous Fungi in Heart Transplant Patients
Official title: Multicenter Retrospective Cohort Study on Invasive Fungal Infections With Filamentous Fungi in Heart Transplant Patients
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Invasive Fungal Infections
Keywords: Invasive Fungal Infections
Filamentous fungi
Heart transplant
Fungal infections
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2024-07-12
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patient ≥18 years old having heart transplant and invasive fungal infection with filamentous fungi during the period from January 1, 2008 to December 31, 2022

Brief summary: Invasive filamentous fungal infections (aspergillosis, scedosporiosis, mucormycosis, fusarium wilt) are common and serious in immunocompromised subjects and particularly organ transplant patients. There is little recent data in heart transplantation, particularly on the incidence and risk factors of fungal infections. . It is therefore important to have recent data on incidence, risk and prognostic factors in order to improve the management of this severe complication.


Eligibility criteria: Inclusion Criteria:

* Adult patient ≥18 years old
* Heart transplant
* Invasive fungal infection with filamentous fungi during the period from January 1, 2008 to December 31, 2022
* Proven or probable infection with filamentous fungi according to EORTC/MSGERC criteria (20):

  * Invasive aspergillosis
  * Mucormycosis
  * Fusarium wilt
  * Scedosporiosis
  * Other filamentous fungus infection
* Subject who has not expressed, after information, his opposition to the reuse of his data for the purposes of this research.

Exclusion Criteria:

* Patient having expressed his opposition to participating in the study
* Patient not having a liver transplant
* Subject under guardianship, curatorship or safeguard of justice.

Primary outcomes:
measure: To identify the incidence, risk factors and prognostic factors associated with invasive fungal infections caused by filamentous fungi in heart transplant patients.
timeFrame: Up to 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France
Study officials:
References:
Clinical trial NCT06551610: CAN3T - Canadian TAVI Triage Tool
Official title: A Step-Wedged Cluster Randomized Registry-Based Multi-Centre Trial to Compare the Efficacy Between the Canadian TAVI Triage Tool and Standard of Care in TAVI Patients in Ontario, Canada
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Aortic Stenosis
Keywords: aortic stenosis
TAVI
Trans-catheter Aortic Valve Implantation
cardiovascular disease
Surgical Aortic Valve Replacement
Lead sponsor: Sunnybrook Health Sciences Centre
Sponsor class: OTHER
First posted: 2024-08-13
Enrollment: 5060
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: Step-Wedged Cluster Randomized
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The goal of this trial is to see if a tool that may reduce wait times will reduce bad outcomes in participants on the TAVI waitlist. The main questions it aims to answer are:

* How many deaths, hospitalizations, or urgent TAVI procedures take place while participants wait
* Days alive and out of hospital at 30 days and 12 weeks, total health care costs, and wait times

Researchers will compare usual wait times to see if the tool reduces death, hospitalizations, and urgent procedures.


Eligibility criteria: Inclusion Criteria:

* All patients referred for TAVI who are 18 years or older at one of 11 TAVI hospitals

Exclusion Criteria:

* Any inpatient referrals who have an urgent inpatient TAVI on the same admission
* Any referral during the 1-month transition period

Primary outcomes:
measure: To assess the efficacy of using the CAN3T tool in triage compared to standard care, in TAVI patients, including: reduce wait-time adverse events, improve patient-centred outcomes, and reduce wait-time health care utilization.
timeFrame: From the beginning of enrollment and continuing for 32 months.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03182010: Ultrasound Evaluation of Cesarean Scar After Uterotomy Closure With Barbed and Conventional Sutures
Official title: Ultrasound Evaluation of Cesarean Scar After Uterotomy Closure With Barbed and Conventional Sutures ; a Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cesarean Section Scar
Keywords: Cesarean section scar, Barbed suture, Conventional suture
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2017-06-09
Enrollment: 110
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this randomized control trial is to compare the residual myometrial thickness and the depth of cesarean section scar defect after uterine incision closure with barbed or conventional sutures.

Detailed description: The aim of this randomized control trial is to compare the residual myometrial thickness and the depth of cesarean section scar defect after uterine incision closure with barbed or conventional sutures. Primigravida patients undergoing transverse lower segment cesarean section will be included in the study.Cesarean section incision will be closed with double layers of continuous barbed or conventional sutures. Ultrasound examination will be performed 6 months after the operation to measure the residual myometrial thickness and the scar depth.

Eligibility criteria: Inclusion Criteria:

* Primigravida patients undergoing transverse lower segment cesarean section

Exclusion Criteria:

* Previous laparotomies
* Postoperative fever
* Patients with preterm pregnancies or in labor

Primary outcomes:
measure: Residual myometrial thickness
timeFrame: Six months after cesarean section
Secondary outcomes:
measure: Scar depth
timeFrame: Six months after cesarean section
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo university
Study officials:
affiliation: Cairo University
name: Usama M Fouda, Prof.
role: STUDY_CHAIR
affiliation: Cairo University
name: Mohamed Zayed, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03582410: Different Types of Suture for Sacral Colpopexy
Official title: Absorbable vs Non-absorbable Suture in Laparoscopic Sacral Colpopexy: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pelvic Organ Prolapse
Lead sponsor: Catholic University of the Sacred Heart
Sponsor class: OTHER
Collaborators: name: Miulli General Hospital
First posted: 2018-07-11
Enrollment: 150
Sex: FEMALE
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This randomized controlled study is designed to test absorbable suture compared to non absorbable suture in laparoscopic sacral colpopexy in terms of anatomical correction of the prolapse, post-operative and long term morbidity, rate of recurrence, subjective satisfaction of the patient and rate of mesh erosion.


Eligibility criteria: Inclusion Criteria:

* patients who required surgical treatment for symptomatic pelvic organ prolapse stage ≥ 2 with or without stress urinary incontinence

Exclusion Criteria:

* Age \> 75 years
* Severe cardiovascular or respiratory disease
* Pregnancy

Primary outcomes:
measure: Number of patients with anatomical correction of the prolapse
timeFrame: 1 year
Secondary outcomes:
measure: rate mesh erosion
timeFrame: 1 year
measure: long term outcomes
timeFrame: 1 year
measure: Rate of recurrence
timeFrame: 1 year
Other outcomes:
Locations:
city: Acquaviva delle Fonti
country: Italy
facility: ospedale regionale Miulli
state: Bari
Study officials:
References:
Clinical trial NCT00687310: Does Tailored Education in Asthma Care Help Improve Patient Satisfaction, Adherence, and Quality of Life (TEACH) Trial
Official title: Does Tailored Education in Asthma Care Help Improve Patient Satisfaction, Adherence, and Quality of Life (TEACH) Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Asthma
Keywords: Asthma education
satisfaction adherence
Quality of Life
PIKO meter cluster
Symbicort® Turbuhaler®
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2008-05-30
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The primary purpose of this study is to assess whether tailored patient education for patients on Symbicort® Turbuhaler® therapy improves patient satisfaction, adherence and Quality of Life.


Eligibility criteria: Inclusion Criteria:

* Patients with the diagnosis of asthma.
* Patients with asthma, where the use of Symbicort® Turbuhaler® is indicated and would have been prescribed by the investigator as part of usual care.
* Patient who have public or private insurance coverage for Symbicort® Turbuhaler® or are willing to pay for this medication for the duration of the trial.

Exclusion Criteria:

* Patients who have been treated wth Symbicort® Turbuhaler® in the preceding 3 months.
* A history of smoking \[i.e., 10 pack-years where one pack-year equals one pack (20 cigarettes) per day for one year, or equivalent\].

Primary outcomes:
measure: Patient's satisfaction with asthma education
timeFrame: At the initial visit (Visit 1) and during the final call (Call 2) or at the time of premature discontinuation from the trial.
Secondary outcomes:
measure: Mini-asthma Quality of Life questionnaire
timeFrame: Visit 1 and during calls 1 and 2
measure: Asthma control parameters
timeFrame: At baseline, as well as during Call 1 and Call 2 for both the usual care group and the enducational intervention group.
measure: PIKO meter usage assessment
timeFrame: During the Call 2 to the educational intervention group subjects who received the PIKO meter during their educational session.
Other outcomes:
Locations:
Study officials:
affiliation: McMaster University
name: Andrew McIvor, M.D., M.Sc., FRCP(E), FRCP(C)
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Ontario London Ontario Canada
name: Christopher Licskai, M.D., FRCPC
role: PRINCIPAL_INVESTIGATOR
affiliation: York Central Hospital, Richmond Hill, Ontario Canada
name: Alan Kaplan, M.D., CCFP, CCFP(E.M.)
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02769910: Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic Itch
Official title: The Role of Pre-established Skin Inflammation on the Susceptibility to Histamine and Cowhage-induced Itch in Healthy Humans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Pruritus
Lead sponsor: Aalborg University
Sponsor class: OTHER
First posted: 2016-05-12
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this project is to investigate the effect of capsaicin-induced neurogenic inflammation with three different intensities on itch subsequently induced by histamine and cowhage. The hypothesis is that capsaicin-induced pre-established neurogenic inflammation significantly increases susceptibility to itch provocations with cowhage and histamine.


Eligibility criteria: Inclusion Criteria:

* Healthy men and women
* 18-60 years
* Caucasian descent
* Speak and understand English

Exclusion Criteria:

* Pregnancy or lactation
* Drug addiction defined as any use of cannabis, opioids or other drugs
* Previous or current neurologic, musculoskeletal or mental illnesses
* Lack of ability to cooperate
* Current use of medications that may affect the trial
* Skin diseases
* Consumption of alcohol or painkillers 24 hours before the study days and between these
* Moles or tattoos in the area to be irradiated
* Exposure of the irradiated area to UV radiation (e.g., sun) 48 hours before the study days and between these
* Acute or chronic pain
* Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)

Primary outcomes:
measure: Itch intensity
timeFrame: Assessed continuously at 0-10 minutes following itch provocation
Secondary outcomes:
measure: Neurogenic inflammation
timeFrame: Assessed 11 minutes after itch provocation
measure: Changes in sensitivity to touch-evoked itch
timeFrame: Assessed before, and at 12-15 minutes following itch provocation
measure: Wheal size
timeFrame: Assessed at 10 minutes following itch provocation
measure: Pain intensity
timeFrame: Assessed continuously at 0-10 minutes following itch provocation
measure: Pain during capsaicin application
timeFrame: 24 hours after first application of capsaicin patch
Other outcomes:
Locations:
city: Aalborg
country: Denmark
facility: SMI
state: NJ
Study officials:
References:
Clinical trial NCT02599610: Effects of Digital Vaginal Examination During Labor on Pain and Anxiety Levels
Official title: Effects of Digital Vaginal Examination During Labor on Pain and Anxiety : a Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pregnancy
Obstetric Labor
Keywords: labor, vaginal examination, transperineal ultrasound, pain, anxiety
Lead sponsor: Ankara University
Sponsor class: OTHER
First posted: 2015-11-06
Enrollment: 40
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Digital vaginal examination is the most common method for assessing progress of labor and delivery. Considering it is the most common intervention women receive during course of labor, evidence for psychological effects of digital vaginal examination on women is surprisingly sparse. Reducing the number of vaginal examination during labor has been proposed by many authors as benefit of more vaginal examination is unclear. However this is unlikely to happen until more research on the topic demonstrates clear detrimental effects of vaginal examination.

Our study is aimed at investigating association of vaginal examination with psychological distress of women during labor. Anxiety during labor is associated with longer labor duration, increased perception of pain, problems with newborn attachment, and increased rates of postpartum depression and post-traumatic stress disorder. In this study, women were assigned to either digital vaginal examination or transperineal ultrasound assessment groups were compared to each other in a randomised controlled setting.


Eligibility criteria: Inclusion Criteria:

* Multiparous women
* Spontaneous active labor
* Cephalic presentation

Exclusion Criteria:

* Women with known psychiatric disorders
* Labor induction
* Advanced labor during admission (Dilatation greater than 7cm)
* Presence of a prenatally diagnosed anomaly in fetus
* Admission to neonatal intensive care unit after delivery
* Delayed hospital discharge due to excessive weight loss of neonate

Primary outcomes:
measure: Anxiety levels
timeFrame: Between 12 to 48 hours
measure: Labor pain
timeFrame: Between 12 to 48 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology
Study officials:
affiliation: Ankara University
name: Erkan Kalafat, MD
role: PRINCIPAL_INVESTIGATOR
References: