Clinical trial NCT01587521: Prevalence of and Factors Associated With Metabolic Syndrome in Schizophrenia
Official title: Prevalence of and Factors Associated With Metabolic Syndrome in Patients With Schizophrenia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Metabolic Syndrome
Quality of Life
Depression
Keywords: Metabolic syndrome
Prevalence
Quality of life
Depression
Antipsychotics
Lead sponsor: Chiang Mai University
Sponsor class: OTHER
First posted: 2012-04-30
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants diagnosed with schizophrenia

Brief summary: Patients with schizophrenia are more likely to have metabolic syndrome compared to general population. The criterion for metabolic syndrome in Asian people including: elevated waist circumference (male ≥ 90cm, female ≥ 80cm), elevated triglycerides ≥ 150mg/dL, reduced HDL cholesterol: male \< 40mg/dL, female \< 50mg/dL, elevated blood pressure: ≥ 130/85 mmHg, elevated fasting glucose: ≥ 100mg/dL. Several factors have been found to be associated with metabolic syndrome in schizophrenia, e.g. age, antipsychotic drugs, smoking, family history of metabolic disorder, stress, and quality of life.

However, little is known about the prevalence of and factors associated in Asian. This study aimed to:

1. Identify the prevalence of metabolic syndrome in patients with schizophrenia.
2. Identify the factors associated with metabolic syndrome in patients with schizophrenia.

Detailed description: Patients with schizophrenia are more likely to have metabolic syndrome compared to general population. The criterion for metabolic syndrome in Asian people including: elevated waist circumference (male ≥ 90cm, female ≥ 80cm), elevated triglycerides ≥ 150mg/dL, reduced HDL cholesterol: male \< 40mg/dL, female \< 50mg/dL, elevated blood pressure: ≥ 130/85 mmHg, elevated fasting glucose: ≥ 100mg/dL. Several factors have been found to be associated with metabolic syndrome in schizophrenia, e.g. age, antipsychotic drugs, smoking, family history of metabolic disorder, stress, and quality of life.

However, little is known about the prevalence of and factors associated in Asian. This study aimed to:

1. Identify the prevalence of metabolic syndrome in patients with schizophrenia.
2. Identify the factors associated with metabolic syndrome in patients with schizophrenia.

Method This study is a cross-sectional study conducting at the Faculty of Medicine, Chiang Mai University. Eighty participants will be recruited with the inclusion criteria of having diagnosed with schizophrenia according to DSM-IV-TR and aged 18 years or over. The exclusion criterion is having organic brain syndrome.

Measurements PANSS CDSS WHOQOL-BREF-THAI

Eligibility criteria: Inclusion Criteria:

* Diagnosis of schizophrenia according to DSM-IV-TR
* Aged 18 years-old or over

Exclusion Criteria:

* Having organic brain syndromes

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Chiang Mai
country: Thailand
facility: Chiang Mai University
Study officials:
affiliation: Chiang Mai University
name: Sirijit Suttajit, MD. MSc.
role: STUDY_DIRECTOR
References: