Clinical trial NCT06107543: Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation
Official title: Retrospective Investigation of the Effects of Different Uses of Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lidocaine
Keywords: Lidocaine
Intubation
General anaesthesia
Lead sponsor: Derince Training and Research Hospital
Sponsor class: OTHER
First posted: 2023-10-30
Enrollment: 94
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 80 patients over the age of 18 and under the age of 80 who underwent surgery under general anesthesia in the operating room will be included in the study.

Brief summary: Direct laryngoscopy and endotracheal intubation procedure stimulate the sympathetic nervous system, causing catecholamine release into the circulation and consequently hemodynamic changes.There are many studies showing that lidocaine is used intravenously to suppress the sympathetic response to laryngoscopy and endotracheal intubation. Nebulized lidocaine is often used to provide upper airway local anesthesia in fiberoptic guided awake intubation.

In this study, the researchers aimed to compare the results of using intravenous lidocaine and nebulized lidocaine to suppress the hemodynamic response caused by laryngoscopy and endotracheal intubation retrospectively.

Researchers' hypothesis; Nebulized lidocaine administration is more effective than intravenous lidocaine administration in suppressing the hemodynamic response due to laryngoscopy and endotracheal intubation in patients under general anesthesia.

Detailed description: 2% lidocaine drug to suppress the hemodynamic response due to laryngoscopy and endotracheal intubation; patients administered intravenously will be evaluated in one group, and patients administered inhaled through a nebulizer will be evaluated in another group.

Nebulized lidocaine in the researchers' clinic; it is administered by adding 2% lidocaine + physiological saline to a nebulizer and inhaling for 3-5 minutes in the presence of 4-6 liters/minute of oxygen.

Preoperative examination forms and intraoperative follow-up forms of the patients included in the study will be examined by the researchers. The dose of lidocaine applied and the method of administration will be recorded. In addition, the agents used in anesthesia induction (fentanyl, propofol, rocuronium bromide, etc.) and the hemodynamic changes of the patients (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure,oxygen saturation) will be recorded.

Eligibility criteria: Inclusion Criteria:

* Patients over the age of 18 and under the age of 80 who underwent surgery under general anesthesia

Exclusion Criteria:

* Patients under the age of 18 and over the age of 80
* Patients who are not operated under general anesthesia

Primary outcomes:
measure: Heart Rate
timeFrame: Just before induction of anesthesia
measure: Heart Rate
timeFrame: Immediately after induction of anesthesia
measure: Heart Rate
timeFrame: 5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation
measure: Blood Pressure
timeFrame: Just before induction of anesthesia
measure: Blood Pressure
timeFrame: Immediately after induction of anesthesia
measure: Blood Pressure
timeFrame: 5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation
measure: Oxygen Saturation
timeFrame: Just before induction of anesthesia
measure: Oxygen Saturation
timeFrame: Immediately after induction of anesthesia
measure: Oxygen Saturation
timeFrame: 5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation
Secondary outcomes:
Other outcomes:
Locations:
city: Kocaeli
country: Turkey
facility: Derince Training and Research Hospital
Study officials:
References:
citation: Baronia AK, Singh PK, Maheshwari A, Jain VK, Mittal P, Pant KC. Inhaled lidocaine for prevention of hemodynamic changes in laryngoscopy and intubation. J Neurosurg Anesthesiol. 1992 Jul;4(3):154-9. doi: 10.1097/00008506-199207000-00002.
citation: Sklar BZ, Lurie S, Ezri T, Krichelli D, Savir I, Soroker D. Lidocaine inhalation attenuates the circulatory response to laryngoscopy and endotracheal intubation. J Clin Anesth. 1992 Sep-Oct;4(5):382-5. doi: 10.1016/0952-8180(92)90160-3.