Clinical trial NCT02550821: Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects
Official title: Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bronchiectasis
Keywords: Physical activity levels
Bronchiectasis
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2015-09-16
Enrollment: 76
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study population will consist of patients with bronchiectasis and healthy subjects.

Brief summary: The purpose of this study is to compare physical activity levels between patients with bronchiectasis and healthy subjects.

We hypothesize that patients with bronchiectasis will have lower levels of physical activity, since physical activity levels is affected by reduced exercise tolerance, severity of disease and other disease related symptoms and conditions.

Detailed description: Physical activity limitation in chronic respiratory diseases is caused by many factors including respiratory, hemodynamic, and peripheral muscle weakness. Bronchiectasis is characterized by irreversible widening of the medium-sized airways, with inflammation, chronic bacterial infection and destruction of the bronchial walls. In addition to pulmonary function worsening, extra pulmonary features such as reduced peripheral muscle endurance can be a significant physical problem which causing a decrease in physical activity levels.

Despite physical activity is considered to be essential for the management of chronic respiratory diseases, there is a lack of scientific study, which compares physical activity levels between patients with bronchiectasis and healthy subjects.

This study will assess physical activity level, exercise capacity, quality of life and peripheral muscle strength in patients with bronchiectasis compared to healthy subjects.

Eligibility criteria: Inclusion Criteria:

Inclusion criteria of the Bronchiectasis Group:

1. Diagnosis of bronchiectasis
2. Being 18 years of age or older
3. Able and willing to complete the informed consent process.
4. Able to walk and co-operate

Exclusion Criteria:

Exclusion criteria of Bronchiectasis Group:

1. Unstable medical condition
2. To have severe neurological, orthopedic problems or severe heart failure.

The control group will consist of healthy subjects.

Primary outcomes:
measure: Number of steps on accelerometer
timeFrame: Seven days
measure: Energy expenditure on activity monitor
timeFrame: Seven days
measure: Exercise capacity using 6-minute walk test and incremental shuttle walk test
timeFrame: 8th day (after using device)
measure: Physical activity level using International Physical Activity Questionnaire
timeFrame: 8th day
Secondary outcomes:
measure: Shortness of breath using the Modified Medical Research Council Dyspnea Scale
timeFrame: 1st day (before using device)
measure: Quality of Life using St. George Respiratory Questionnaire
timeFrame: 1st day
measure: Peripheral muscle strength test using a hand-held dynamometer
timeFrame: 8th day (after using device)
measure: Maximal inspiratory and expiratory pressures measurement using a mouthpiece device
timeFrame: 8th day (after using device)
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Aslihan Cakmak
Study officials:
affiliation: Hacettepe University
name: ASLIHAN CAKMAK
role: PRINCIPAL_INVESTIGATOR
References: