Clinical trial NCT06861764: The Relationship Between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients
Official title: The Relationship Between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients: a Multicenter Prospective Cohort
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cohort Studies
Keywords: preoperative anxiety
Aged
postoperative delirium
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
Collaborators: name: Beijing Tiantan Hospital
name: Peking University First Hospital
name: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
name: Xiangya Hospital of Central South University
name: Beijing Anzhen Hospital
name: Central South University
name: Peking University People's Hospital
name: Zhejiang University
name: Fudan University
name: Sun Yat-sen University
name: Wuhan Union Hospital, China
name: China-Japan Friendship Hospital
name: The Affiliated Hospital Of Guizhou Medical University
name: First Affiliated Hospital of Xinjiang Medical University
name: First Affiliated Hospital of Guangxi Medical University
name: Taihe Hospital
name: Zhejiang Provincial People's Hospital
name: Shanghai Zhongshan Hospital
First posted: 2025-03-06
Enrollment: 8000
Sex: ALL
Minimum age (years): 65
Maximum age (years): 100
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Elderly patients (aged ≥ 65 years) who completed the anxiety assessment after the elective noncardiac, non-neurosurgical surgery were included in this study.

Brief summary: This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the the relationship between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients: a Multicenter Prospective Cohort

Detailed description: This is a retrospective cohort study using prospective data from a multicenter database. 8000 elderly patients undergoing elective non-cardiac or non-neurosurgical surgery were included in this study. The Generalized Anxiety Disorder Scale (GAD-7) was used to measure preoperative anxiety symptoms. The confusion assessment method (3D-CAM) was used to assess postoperative delirium in elderly patients undergoing non-cardiac surgery. If the patient is discharged, follow up by phone or email. Binary logistic regression analysis and propensity score matching (PSM) and subgroup analysis were used to analyze the data.

Eligibility criteria: Inclusion Criteria:

* elderly patients (age ≥ 65 years)
* non-cardiac surgery, non-neurosurgical surgery

Exclusion Criteria:

* History of neurological or psychiatric disorders or use of neuropsychiatric drugs;
* Impaired cognitive function or inability to cooperate with preoperative follow-up;
* Sent to ICU after surgery;
* Deletional delirium outcome;
* Baseline missing \>5%

Primary outcomes:
measure: Postoperative delirium
timeFrame: within 7 days after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Chinese PLA General Hospital
state: Beijing
Study officials:
References: