Clinical trial NCT03503084: Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function
Official title: The Effect of Tai Chi Chuan on the Endothelin, Insulin, Blood Lipid, Blood Sugar, Aldosterone and Hemodynamics in the Elderly Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physiological Effect of TCC on Glucose Metabolism
Keywords: Tai Chi Chuan
insulin resistance
cholesterol
endothelin-1
Lead sponsor: Changhua Christian Hospital
Sponsor class: OTHER
Collaborators: name: Taipei Veterans General Hospital, Taiwan
First posted: 2018-04-19
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The short term effects of TCC exercise are the significant increase in serum insulin and insulin resistance, and the significant decrease in serum TC, HDL-C, ET-1 and insulin sensitivity in TCC practitioners. TCC might be benefit the health of its practitioners through the regulation of lipid and glucose metabolism and endothelial function.

Detailed description: Tai Chi Chuan (TCC) has been shown to be beneficial to the health. However, its effects on lipid and glucose metabolism are not fully understood. This study investigated the short term effect of TCC exercise on lipid and glucose metabolism and endothelial function in TCC practitioners. Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.

Eligibility criteria: Inclusion Criteria:

* TCC practitioners in a TCC training center in Taiwan over 50 years of age
* Healthy subjects without TCC experience over 50 years of age

Exclusion Criteria:

* Subjects who had major cardiopulmonary disease
* Subjects who have diabetes mellitus, renal or liver disease

Primary outcomes:
measure: change in quantitative insulin sensitivity check index
timeFrame: before and 30 minutes after the completion of TCC exercise
Secondary outcomes:
measure: change in serum total cholesterol
timeFrame: before and 30 minutes after the completion of TCC exercise
measure: change in homeostasis model assessment-estimated insulin resistance
timeFrame: before and 30 minutes after the completion of TCC exercise
Other outcomes:
measure: change in serum triglyceride
timeFrame: before and 30 minutes after the completion of TCC exercise
measure: change in serum low density lipoprotein
timeFrame: before and 30 minutes after the completion of TCC exercise
measure: change in serum high density lipoprotein
timeFrame: before and 30 minutes after the completion of TCC exercise
measure: change in serum insulin
timeFrame: before and 30 minutes after the completion of TCC exercise
measure: change in serum endothelin-1
timeFrame: before and 30 minutes after the completion of TCC exercise
measure: change in serum aldosterone
timeFrame: before and 30 minutes after the completion of TCC exercise
Locations:
city: Ilan
country: Taiwan
facility: Wan-An Lu
Study officials:
affiliation: Changhua Christian Hospital
name: Cheng-Deng Kuo, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Lu WA, Kuo CD. Three months of Tai Chi Chuan exercise can reduce serum triglyceride and endothelin-1 in the elderly. Complement Ther Clin Pract. 2013 Nov;19(4):204-8. doi: 10.1016/j.ctcp.2013.06.007. Epub 2013 Jul 27.
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