Clinical trial NCT06325410: Prognostic Factors Influencing the Recurrence Rate and Survival of Patients With Colorectal Cancer: a Single Institution Experience
Official title: Prognostic Factors Influencing the Recurrence Rate and Survival of Patients With Colorectal Cancer: a Single Institution Experience
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Colorectal Cancer
Keywords: colorectal
cancer
recurrence
prognosis
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
First posted: 2024-03-22
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patient with newely diagnosed colorectal cancer were followed up after surgery to detect if there was a recurrence prospectively, while patients with recurrent colorectal cancer were studied retrospectively to find out factors influencing the recurrence

Brief summary: over the past decade colon cancer has emerged as the second most deadly and the third most common type of cancer in the world with increasing incidence in Egypt due to life style and diet change. some research showed relation between colon cancer recurrence and advanced tumor staging. To investigators knowledge, this is the first time to be done in Zagazig University.

Data was collected from records in a retrospective cohort study


Eligibility criteria: Inclusion Criteria:

* Adult patients with newly diagnosed colorectal cancer
* Age \> 18 years old
* recurrent cases of colorectal cancer

Exclusion Criteria:

* Pediartric patient less than 18 yr
* In operable or metastatic cancer colon
* No other malignancies

Primary outcomes:
measure: age
timeFrame: through study completion, an average of 5 years
measure: sex
timeFrame: through study completion, an average of 5 years
measure: medical disease
timeFrame: through study completion, an average of 5 years
measure: previous surgery
timeFrame: through study completion, an average of 5 years
measure: CEA
timeFrame: through study completion, an average of 5 years
measure: tumor grade
timeFrame: through study completion, an average of 5 years
measure: tumor site
timeFrame: through study completion, an average of 5 years
measure: tumor size
timeFrame: through study completion, an average of 5 years
measure: surgical margins of resected tumor
timeFrame: through study completion, an average of 5 years
measure: neoadjuvant therapy
timeFrame: through study completion, an average of 5 years
measure: adjuvant therapy
timeFrame: through study completion, an average of 5 years
measure: diet
timeFrame: through study completion, an average of 5 years
measure: occupation
timeFrame: through study completion, an average of 5 years
measure: family history
timeFrame: through study completion, an average of 5 years
measure: type of surgery(laparoscopic or open)
timeFrame: through study completion, an average of 5 years
measure: soiling by during surgery
timeFrame: through study completion, an average of 5 years
measure: hand sewen or stappled anastmosis
timeFrame: through study completion, an average of 5 years
measure: post operative complications
timeFrame: through study completion, an average of 5 years
measure: site of recurrence
timeFrame: through study completion, an average of 5 years
measure: type of resected tumor
timeFrame: through study completion, an average of 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Zagazig
country: Egypt
facility: Zagazig University Hospitals
Study officials:
affiliation: faculty of medicine Zagazig University
name: Reham Zakaria, PhD
role: PRINCIPAL_INVESTIGATOR
References: