Clinical trial NCT01324050: Internet-delivered Psychodynamic Therapy for Depression
Official title: Internet-delivered Psychodynamic Therapy for Depression: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Depression
Lead sponsor: Linkoeping University
Sponsor class: OTHER_GOV
First posted: 2011-03-28
Enrollment: 92
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The overall aim of this study is to develop and test a psychodynamic Internet-delivered psychological treatment for patients with mild to moderate major depression and compare its efficacy to an active control group.


Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of Major Depressive Disorder
* 15 or more on MADRS-S

Exclusion Criteria:

* Severe depression (more than 35 on MADRS-S or based on interview)
* Severe psychiatric condition (e.g. psychosis or bipolar disorder)
* Suicidal (measured in diagnostic interview)
* Changed medication during the last three months

Primary outcomes:
measure: Beck Depression Inventory (BDI)
timeFrame: Two weeks before the treatment starts
measure: Beck Depression Inventory (BDI)
timeFrame: At treatment start (0 weeks)
measure: Beck Depression Inventory (BDI)
timeFrame: At treatment termination (10 weeks)
Secondary outcomes:
measure: Beck Anxiety Inventory (BAI)
timeFrame: Two weeks before the treatment starts
measure: Beck Anxiety Inventory (BAI)
timeFrame: At treatment termination (10 weeks)
measure: Montgomery Åsberg Depression Rating Scale Self-report (MADRS-S)
timeFrame: Two weeks before treatment starts
measure: Montgomery Åsberg Depression Rating Scale Self-report (MADRS-S)
timeFrame: At treatment termination (10 weeks)
measure: Quality of Life Inventory (QOLI)
timeFrame: Two weeks before treatment starts
measure: Quality of Life Inventory (QOLI)
timeFrame: At treatment termination (10 weeks)
measure: Patient Health Questionnaire 9 (PHQ-9)
timeFrame: Two weeks before treatment starts
measure: Patient Health Questionnaire 9 (PHQ-9)
timeFrame: At treatment termination (10 weeks)
measure: Generalised Anxiety Disorder Assessment 7 (GAD-7)
timeFrame: Two weeks before treatment starts
measure: Generalised Anxiety Disorder Assessment 7 (GAD-7)
timeFrame: At treatment termination (10 weeks)
Other outcomes:
Locations:
city: Linköping
country: Sweden
facility: Linköping University, Department of Behavioral Sciences and Learning
city: Linköping
country: Sweden
facility: Linköping University
Study officials:
affiliation: Department of Behavioral Sciences and Learning, Linköping University
name: Gerhard Andersson, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Johansson R, Nyblom A, Carlbring P, Cuijpers P, Andersson G. Choosing between Internet-based psychodynamic versus cognitive behavioral therapy for depression: a pilot preference study. BMC Psychiatry. 2013 Oct 18;13:268. doi: 10.1186/1471-244X-13-268.
citation: Johansson R, Ekbladh S, Hebert A, Lindstrom M, Moller S, Petitt E, Poysti S, Larsson MH, Rousseau A, Carlbring P, Cuijpers P, Andersson G. Psychodynamic guided self-help for adult depression through the internet: a randomised controlled trial. PLoS One. 2012;7(5):e38021. doi: 10.1371/journal.pone.0038021. Epub 2012 May 29.