Clinical trial NCT05876403: Respiratory Proprioceptive Neuromuscular Facilitation Technique in Chronic Pulmonary Obstructive Disease Patients.
Official title: Effects of Respiratory Proprioceptive Neuromuscular Facilitation (PNF) Technique on Pulmonary Function of Chronic Pulmonary Obstructive Disease (COPD) Patients.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Keywords: Peak Expiratory Flow Rate (PEFR)
Pulmonary function
PNF techniques
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-05-25
Enrollment: 56
Sex: ALL
Minimum age (years): 35
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of this study is to evaluate the impact of PNF technique combined with aerobic exercises among COPD patients in a clinical setting. Previous literature has evaluated this technique in ventilated patients but in clinical setting specifically in Pakistan, this invention therapy has not been implied in COPD patients.

Detailed description: Chronic Obstructive Pulmonary Disorder manifested as breathlessness, respiratory difficulties and persistent cough is one of the biggest causes of mortality around the world. 2.1% of Pakistani population has COPD. Proprioceptive neuromuscular facilitation is used as management technique in which muscle stretching promotes chest wall mobility and restores regular breathing rhythm. In previous studies, PNF technique combined with aerobic exercises has been utilized to improve Pulmonary functions in COPD patients. But the sample size of these studies was small and participants were ventilated patients, hence not targeting the diaphragm. Our study shall evaluate the impact of PNF technique combined with aerobic training on the Pulmonary function of COPD patients in the clinical setting.

Eligibility criteria: Inclusion Criteria:

* Both male \& female participants.
* Diagnosed COPD patients
* Age 35-60years
* Ratio of forced expiratory volume in first second \& forced vital capacity(FEV1/FVC \<0.7,30%\<FEV1\<80%
* Stable clinical condition.

Exclusion Criteria:

* Serious conditions with require supplementary oxygen or ventilator/support devices.
* COPD exacerbation within last 4weeks
* Patients with recent chest wall trauma, surgery or deformity.
* Patient with neurological, psychological, musculoskeletal, or cardiac medical history.
* Pulmonary disease with physical impairment.
* Inability to follow the pulmonary rehabilitation program.

Primary outcomes:
measure: Peak expiratory flow rate (PEFR)
timeFrame: two weeks
measure: Forced vital capacity (FVC)
timeFrame: two weeks
measure: Forced expiratory volume in 1sec (FEV1)
timeFrame: two weeks
measure: Chest Expansion
timeFrame: two weeks
measure: Modified Borg Dyspnea Scale
timeFrame: two weeks
measure: COPD assessment test
timeFrame: two weeks
Secondary outcomes:
measure: 6 minutes walk test:
timeFrame: two weeks
Other outcomes:
Locations:
city: Islamabad
country: Pakistan
facility: Pakistan Railway General Hospital
state: AL
Study officials:
affiliation: Riphah International University
name: Suman Sheraz, PhD*
role: PRINCIPAL_INVESTIGATOR
References:
citation: Putt MT, Watson M, Seale H, Paratz JD. Muscle stretching technique increases vital capacity and range of motion in patients with chronic obstructive pulmonary disease. Arch Phys Med Rehabil. 2008 Jun;89(6):1103-7. doi: 10.1016/j.apmr.2007.11.033.
citation: Liu K, Yu X, Cui X, Su Y, Sun L, Yang J, Han W. Effects of Proprioceptive Neuromuscular Facilitation Stretching Combined with Aerobic Training on Pulmonary Function in COPD Patients: A Randomized Controlled Trial. Int J Chron Obstruct Pulmon Dis. 2021 Apr 13;16:969-977. doi: 10.2147/COPD.S300569. eCollection 2021.
citation: Reddy RS, Alahmari KA, Silvian PS, Ahmad IA, Kakarparthi VN, Rengaramanujam K. Reliability of Chest Wall Mobility and Its Correlation with Lung Functions in Healthy Nonsmokers, Healthy Smokers, and Patients with COPD. Can Respir J. 2019 Feb 25;2019:5175949. doi: 10.1155/2019/5175949. eCollection 2019.
citation: Make BJ, Yawn BP. Breathing Life Into COPD Management: Ongoing Monitoring, Pulmonary Rehabilitation, and Individualized Care. Chest. 2018 Oct;154(4):980-981. doi: 10.1016/j.chest.2018.08.1023.