Clinical trial NCT05980923: Thyroid Profiles in Patients With Acute Illness
Official title: Thyroid Profiles in Middle Eastern Patients Admitted With Acute Illness: Prevalence, Clinical Features and Impact on Mortality
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Thyroid Dysfunction
Acute Illness
Keywords: Thyroid abnormalities
Acute illness
Prognosis
Middle east
Lead sponsor: Jordan Collaborating Cardiology Group
Sponsor class: OTHER
First posted: 2023-08-08
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: nclusion Criteria: All patients admitted to the hospital with acute illness will have their serum level of thyroid stimulating hormone and free T4 and T3 measured on admission. Clinical and laboratory profiles of patients with abnormal thyroid function (Group 1) will be compared to those with normal thyroid function (Group 2). Serum thyroid test will be repeated at 6 months. Short and long term survival of both groups will be compared as well.

Diagnosis on admission is acute illness includes: heart failure, acute coronary syndrome, sepsis, acute stroke, hypotension, acute system-organ failure including renal and hepatic failure.

Brief summary: Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients.

Detailed description: Recently, there has been a growing body of evidence that subclinical thyroid dysfunction as a contributor to the increase of cardiovascular events. Elevated serum thyroid-stimulating hormone (TSH) levels and normal free thyroxine (FT4) and free triiodothyronine (FT3) levels have been associated with worse heart failure and dyslipidemia. Furthermore, higher risk of atrial fibrillation has been linked tp thyroid abnormalities in these patients.

Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients. This study aimed at evaluating the prevalence of thyroid function abnormalities in patients admitted to hospital with acute illness and their temporal changes and impact on mortality during hospitalization and at 1 year. Serum level of thyroid stimulating hormone and free T4 and T3 measured on admission. Clinical and laboratory profiles of patients with abnormal thyroid function (ATF group) will be compared to those with normal thyroid function (NTF group). Short and long term survival of both groups were compares as well.

Eligibility criteria: Inclusion Criteria:

* Hospital admission
* Adults aged 18 years and above
* Willing to sign an informed consent
* Diagnosis on admission is acute illness that includes: heart failure, acute coronary syndrome, sepsis, acute stroke, hypotension, acute system-organ failure including renal and hepatic failure.

Exclusion Criteria:

* Age less than 18 years.
* Refusal to sign consent.
* Admission for a reason not classified as acute illness.

Primary outcomes:
measure: In hospital mortality
timeFrame: From time of study entry until the date of death from any cause, assessed up to 2 weeks.
Secondary outcomes:
measure: 6-month mortality rate
timeFrame: From date of study entry until the date of death from any cause, assessed up to two weeks.
Other outcomes:
Locations:
city: Amman
country: Jordan
facility: Istishari Hospital
Study officials:
References: