Clinical trial NCT02915679: Pain Perception in Suicidal Behavior Vulnerability
Official title: Pain Perception in Suicidal Behavior Vulnerability
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Major Depressive Episode
Keywords: Suicidal behavior
psychological and social pain
physical pain
pain perception
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2016-09-27
Enrollment: 167
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked.

The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters.

The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts.

After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).

Detailed description: 242 depressed patients ( 81 recent suicide attempters, 81 former suicide attempters, 80 non-attempters)

First visit : clinical assessment Second visit : pain evaluation and blood sample (from one day to a week maximum after the first visit).

Eligibility criteria: Inclusion criteria:

* aged by 18 years old
* came from West Europe, excepted Basque and Sardinian (because of genetics analysis)
* main diagnosis of major depressive episode (DSM V criteria)
* not having take antalgics in the 24 hours before assessment
* received a minimal psychotrope treatment (clinician evaluation)
* Able to understand nature, aims, methodology of the study
* Agree to cooperate in clinical and biological assessment
* Having signed informed consent

Specific inclusion criteria :

81 recent suicide attempters (being hospitalised for suicidal attempts and having realised a suicide attempts 8 days before inclusion) 81 former suicide attempters (having realised in his lifetime a suicide attempt, one month before inclusion)

Exclusion criteria:

* Current diagnosis of manic, hypomanic or alcohol dependance or substance abuse in the last 6 months, or diagnosis of schizophrenia or schizoaffective disorder in his lifetime
* Current algic and chronic neurologic disease
* Current or actual treatment by tricyclic antidepressant and Serotonin and norepinephrine reuptake inhibitors(SNRIs)
* Pregnancy
* Patients on protective measure

Primary outcomes:
measure: Pain tolerance reported by the patient
timeFrame: During thermal stimulation
Secondary outcomes:
measure: Pain intensity reported by the patient
timeFrame: During thermal stimulation
measure: Pain threshold reported by the patient
timeFrame: During thermal stimulation
measure: Temperature assessed at 4/10 on likert scale
timeFrame: During thermal stimulation performed at the inclusion
measure: Kinetics of pain intensity
timeFrame: During thermal stimulation performed at the inclusion
measure: Social distress perception assessed by social distress questionnaire
timeFrame: At V2 (one week maximum after the inclusion)
measure: Social distress perception assessed by the Rejection Sensitivity Questionnaire (RSQ)
timeFrame: At the inclusion
measure: Social rejection sensitivity assessed by the Rejection Sensitivity Questionnaire (RSQ)
timeFrame: At the inclusion
measure: Psychological pain intensity
timeFrame: At V2 (one week maximum after the inclusion)
measure: Measure of cardiac frequency in response to thermal pain
timeFrame: At V2 (one week maximum after the inclusion)
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Montpellier Hospital University
Study officials:
References: