Clinical trial NCT06891846: Relationship Between Magnesium Depletion Score and Extraction Socket Healing
Official title: Evaluation of the Relationship Between Magnesium Depletion Score and Socket Healing Following Tooth Extraction
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Wound Healing
Magnesium Level
Wisdom Tooth Removal
Keywords: blood magnesium level
oral surgery
wound healing
Lead sponsor: Saglik Bilimleri Universitesi
Sponsor class: OTHER
First posted: 2025-03-24
Enrollment: 112
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Systemically healthy adult participants from both sexes, who were scheduled to undergo surgical extraction of lower impacted third molars, with a physical status classified as ASA I according to the American Society of Anesthesiologists (ASA).

Brief summary: The surgical extraction of an impacted tooth is one of the most common procedures in oral surgery. Following extraction, the tissue undergoes repair and regeneration through a process known as socket healing (SH).

SH is a complex and highly regulated biological process. Several local, surgical, and systemic factors can influence SH. This study aimed to evaluate the impact of the magnesium depletion score (MDS) on the socket healing following tooth extraction.

Detailed description: The surgical extraction of impacted teeth is one of the most commonly performed procedures in the field of oral surgery. According to the American Dental Association (ADA), surgical extraction involves "the removal of a tooth that has either erupted or not into the mouth, which includes the removal of a mucoperiosteal flap and the trimming of a portion of the tooth and/or bone." Complications related to post-extraction wound healing-such as pain, swelling, bleeding, and infection-can pose significant challenges for both patients and surgeons. Optimal healing depends not only on the tissue itself but also on various local, surgical, and systemic factors, including but not limited to the patient's stress levels, oral hygiene, age, sex, overall health status, and nutrition, many of which may be beyond intervention or control. Consequently, there is growing interest in treatments that can enhance wound healing. Recent studies indicate that magnesium consumption may have a beneficial effect on the healing process.

Eligibility criteria: Inclusion Criteria:

* Systemically healthy adult participants who were scheduled to undergo surgical extraction of lower impacted third molars.

Exclusion Criteria:

* Refusal to consent
* Presence of chronic diseases
* Use of medications that affect wound healing (steroids, bisphosphonate, or immunosuppressives)
* Prior radiotherapy in the head and neck area
* Pregnancy
* Inability to self-evaluate, and inability to communicate verbally or in writing.

Primary outcomes:
measure: Magnesium depletion score (MDS)
timeFrame: 6 weeks
measure: Assessment of Wound healing (WH)
timeFrame: 6 weeks
Secondary outcomes:
measure: Post-operative pain
timeFrame: 3 days
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Sağlık Bilimleri Üniversitesi Tacirler Eğitim Vakfı Sultanbeyli Ağız ve Diş Sağlığı Hastanesi
state: Sultanbeyli
Study officials:
References:
citation: Ye L, Zhang C, Duan Q, Shao Y, Zhou J. Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease. J Am Heart Assoc. 2023 Sep 19;12(18):e030077. doi: 10.1161/JAHA.123.030077. Epub 2023 Sep 8.
citation: Xu Y, Qin Y, Lu H, Liu L, Huang W, Huang A, Ye Y, Shen H, Guo Z, Chen W. The magnesium depletion score is associated with increased likelihood of kidney stone disease among female adults. J Trace Elem Med Biol. 2024 Jul;84:127432. doi: 10.1016/j.jtemb.2024.127432. Epub 2024 Mar 12.
citation: Wang J, Xing F, Sheng N, Xiang Z. Associations of the Dietary Magnesium Intake and Magnesium Depletion Score With Osteoporosis Among American Adults: Data From the National Health and Nutrition Examination Survey. Front Nutr. 2022 May 31;9:883264. doi: 10.3389/fnut.2022.883264. eCollection 2022.
citation: Fan L, Zhu X, Rosanoff A, Costello RB, Yu C, Ness R, Seidner DL, Murff HJ, Roumie CL, Shrubsole MJ, Dai Q. Magnesium Depletion Score (MDS) Predicts Risk of Systemic Inflammation and Cardiovascular Mortality among US Adults. J Nutr. 2021 Aug 7;151(8):2226-2235. doi: 10.1093/jn/nxab138.
citation: Chen Y, Xiang X, Wu Y, Han S, Huang Z, Wu M. Magnesium Depletion Score Predicts Diabetic Retinopathy Risk among Diabetes: Findings from NHANES 2005-2018. Biol Trace Elem Res. 2023 Jun;201(6):2750-2756. doi: 10.1007/s12011-022-03384-3. Epub 2022 Aug 22.