Clinical trial NCT06283043: Effect of Motor Function, Depression and Sleep Quality on Attention in Parkinson's Disease
Official title: Effect of Motor Function, Depression and Sleep Quality on Attention in Parkinson's Disease
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Movement Disorders (Incl Parkinsonism)
Parkinsonian Disorders
Attention Impaired
Movement Disorders, Functional
Keywords: Parkinson
Attention
motor function
sleep
Lead sponsor: Inonu University
Sponsor class: OTHER
First posted: 2024-02-28
Enrollment: 54
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Parkinson Diseases and Healty Control

Brief summary: Our study was planned to analyze motor function, endurance and sleep attention information in Parkinson's patients with detailed and objective measurements.

Detailed description: Parkinson's Disease (PD) is a neurodegenerative disease that occurs with the loss of dopaminergic neurons in the basal ganglia (BG) and subsequently affects multiple brain regions. There are studies that evaluate executive functions rather than cognitive functions in Parkinson's patients. However, objective evaluations of the attention parameter are quite rare. Accordingly, our study was planned to examine the effects of motor function, depression and sleep on attention in Parkinson's patients with detailed and objective measurements. Parkinson's patients (n=27) and healthy controls (n=27) aged between 40-85 will be included in the study. Balance evaluation of the individuals participating in the study was carried out by functional reaching test, one-leg standing test and Berg balance scale; Endurance with a 30-second sit-and-stand test; reaction time; with mobile application; muscle strength by hand dynamometer; functional mobility with time up and go test; walking speed, with 10 m walk test; attention with the P300 device; depression, with the Beck depression scale; Sleep quality will be assessed with the Pittsburg sleep questionnaire. At the end of the study, the effects of motor functions, sleep and depression on attention will be examined and compared with healthy controls.

Eligibility criteria: Inclusion Criteria:

* Being 1,2 or 3 according to the Hoehn and yahr scale
* Being between the ages of 40-85
* Being diagnosed with Parkinson's according to UPDS
* Being able to read and write
* Being able to walk independently
* Agreeing to participate in the study after providing detailed information about the research.
* Mini mental test\>24

Exclusion Criteria:

* Having severe hearing/visual impairment-loss
* Having an orthopedic, neurological or metabolic disease that may interfere with working
* Having deep brain stimulation applied
* Those with advanced cognitive impairment
* Individuals with dementia
* Patients taking anticholinergic, antidepressive or anxiolytic medications that may affect cognition, and those with other medical or neurological causes that may cause cognitive effects.

Primary outcomes:
measure: TUG
timeFrame: second, day 1, Values over 12 seconds indicate the risk of falling
measure: 10 m walking test
timeFrame: second, day 1, lower results indicate better values, higher results indicate worse results
measure: 30 sec sit-stand test
timeFrame: again,day 1, higher results indicate better values, lower results indicate worse results
measure: berg balance test
timeFrame: score, day 1, The score is between 0-56. A high total score indicates a good result
measure: one leg stance test
timeFrame: second, day 1, higher results indicate better values, lower results indicate worse results
measure: functional reach test
timeFrame: centimeter, day 1, higher results indicate better values, lower results indicate worse results
measure: hand dinamometer
timeFrame: kilogram, day 1, higher results indicate better values, lower results indicate worse results
measure: mobil application
timeFrame: second, day 1, lower results indicate better values, higher results indicate worse results
measure: Pittsburg Sleep Quality İndex
timeFrame: score, day 1, The score is between 0-21. A high total score indicates a bad result.
measure: Beck Depression
timeFrame: score,day 1, The total score is between 0-63. A high total score indicates that the result is bad.
measure: P300
timeFrame: second, day 1, lower results indicate better values, higher results indicate worse results
Secondary outcomes:
Other outcomes:
Locations:
city: Malatya
country: Turkey
facility: Inonu University
state: Battalgazi
Study officials:
References: