louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06127069: Treatment of Residual Pockets in Periodontal Patients Using an Oscillating Chitosan Device
Official title: Treatment of Residual Pockets in Periodontal Patients Using an Oscillating Chitosan Device - A Randomized Parallel Arm Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Periodontitis
Keywords: residual pockets
chitosan
treatment of periodontitis
Lead sponsor: Aristotle University Of Thessaloniki
Sponsor class: OTHER
First posted: 2023-11-13
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: randomized parallel arm clinical trial
Primary purpose: TREATMENT

Brief summary: The aim of the current study was to investigate the effect of a chitosan brush on the treatment of residual pockets in patients already treated for periodontal disease. Thirty-six patients with chronic periodontitis (Stage ΙΙΙ, ΙV) that had already completed causative therapy and exhibited at least two residual periodontal pockets ≥ 5mm that bled on probing, were randomly assigned to two groups. In the test group debridement of residual pockets was performed with ultrasonic scaler and the chitosan brush, whereas in the control group only ultrasonic scalers were used.


Eligibility criteria: Inclusion Criteria:

* Subjects aged 18 or over
* Subjects diagnosed with chronic periodontitis, Stage III or IV, and had received full mouth scaling and root planning at least three months prior to baseline examination
* Subjects with at least two residual periodontal pockets of at least 5mm depth that bled on probing
* Full mouth plaques scores ≤20%

Exclusion Criteria:

* Subjects that had received antibiotic therapy 6 months prior to initial examination
* Subjects with compromised systemic conditions
* Patients undergoing chemotherapy or radiotherapy
* Pregnant or lactating women

Primary outcomes:
measure: Probing Pocket Depth
timeFrame: baseline, 6 weeks, 3 months, 6 months
measure: MMP-8
timeFrame: baseline, 6 weeks, 3 months, 6 months
Secondary outcomes:
measure: Bleeding on Probing
timeFrame: baseline, 6 weeks, 3 months, 6 months
measure: Clinical Attachment Level
timeFrame: baseline, 6 weeks, 3 months, 6 months
measure: Gingival Recession
timeFrame: baseline, 6 weeks, 3 months, 6 months
Other outcomes:
Locations:
city: Thessaloniki
country: Greece
facility: Department of Periodontology, School of Dentistry, Aristotle University of Thessaloniki
Study officials:
affiliation: Department of Periodontology, School of Dentistry, Aristotle University
name: Lazaros Tsalikis
role: STUDY_CHAIR
References:
Clinical trial NCT06549569: Burn Coverage of Burn by Tilapia Fish Skin
Official title: Tilapia Fish Skin Coverage in Acute Thermal Burn; Experimental and Histopathological Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tilapia Fish Skin in Burn Coverage
Lead sponsor: Aswan University
Sponsor class: OTHER
First posted: 2024-08-12
Enrollment: 20
Sex: MALE
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: animal rabbits

Brief summary: The goal of this experimental study is to compare TFS and regular dressings as coverage for acute thermal burns. The main question it aims to answer is:

Is TFS effective in treating thermal burns? burn induction was done on rabbits to obtain second-degree thermal burn, followed by coverage with TFS

Detailed description: Nile Tilapia Fish Skin (NTFS) has been suggested as an option for biological material for the management of burns. Nile Tilapia Fish Skin also presented a large composition of type I collagen, morphology similar to human skin and high resistance and tensile extension at the break. We chose Baladi rabbits for their relatively ease of handling, accommodation and resistance to surgical aggressions and infectious processes, with low mortality. However, the choice of male rabbits is due to variations in hormonal cycles in females that could intervene in the process of tissue repair.

This experimental model was established to evaluate healing process and outcome results after application of Tilapia Fish Skin on acute contact thermal that was done in order to obtain injuries with the same size and depth.

Eligibility criteria: Inclusion Criteria:

- healthy male one year old rabbit

Exclusion Criteria:

* female unhealthy rabbits

Primary outcomes:
measure: Tilapia Fish Skin Coverage in Acute Thermal Burn
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Aswan
country: Egypt
facility: Amira Anter
Study officials:
References:
Clinical trial NCT02519569: Internet-based Intervention for Complicated Grief: A Pilot Study
Official title: Internet-based Intervention for Complicated Grief: A Pilot Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Complicated Grief
Lead sponsor: University of Tromso
Sponsor class: OTHER
First posted: 2015-08-11
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A considerable proportion of bereaved individuals experience chronic and disabling grief (so-called complicated or prolonged grief). Complicated grief is associated with severe mental and physical health problems as well as impaired social and occupational functioning. Interventions based on cognitive-behavioral therapy and applied via the internet have shown to be efficacious for this condition, but have not yet been adapted and evaluated in Norway. The aim of the current study is to adapt an internet-based cognitive-behavioral intervention for complicated grief and evaluate its effectiveness as a pilot study.


Eligibility criteria: Inclusion Criteria:

* Complicated grief
* Internet access
* Fluent in Norwegian
* No concomitant psychological treatment

Exclusion Criteria:

* Severe depression
* Psychotic symptoms
* Dissociation
* Suicidality

Primary outcomes:
measure: Change from pretest to posttest in symptoms of complicated grief
timeFrame: 6 weeks
measure: Change from pretest to follow-up (1) in symptoms of complicated grief
timeFrame: 18 weeks
measure: Change from pretest to follow-up (2) in symptoms of complicated grief
timeFrame: 30 weeks
Secondary outcomes:
measure: Change from pretest to posttest in posttraumatic growth
timeFrame: 6 weeks
measure: Change from pretest to follow-up (1) in posttraumatic growth
timeFrame: 18 weeks
measure: Change from pretest to follow-up (2) in posttraumatic growth
timeFrame: 30 weeks
measure: Change from pretest to posttest in quality of life
timeFrame: 6 weeks
measure: Change from pretest to follow-up (1) in quality of life
timeFrame: 18 weeks
measure: Change from pretest to follow-up (2) in quality of life
timeFrame: 30 weeks
measure: Change from pretest to posttest in depression
timeFrame: 6 weeks
measure: Change from pretest to follow-up (1) in depression
timeFrame: 18 weeks
measure: Change from pretest to follow-up (2) in depression
timeFrame: 30 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01926769: A Phase II Study to Determine the Safety and Efficacy of Second-line Treatment With Metformin and Chemotherapy (FOLFOX6 or FOFIRI) in the Second Line Threatment of Advanced Colorectal Cancer
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Previously Treated Advanced Colorectal Cancer
Keywords: Colorectal cancer
Metformin
FOLFOX6
FOFIRI
5FU
irinotecan
oxaliplatin
Lead sponsor: Gachon University Gil Medical Center
Sponsor class: OTHER
First posted: 2013-08-21
Enrollment: 2
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To determine the safety and efficacy of second-line treatment with Metformin and Chemotherapy (FOLFOX6 or FOFIRI) in the second line treatment of advanced colorectal cancer


Eligibility criteria: Inclusion Criteria:

* age over 18
* histologically confirmted advanced colorectal cancer
* ECOG PS 0-2
* expected life span more than 3months
* normal bone marrow, liver, renal function

Exclusion Criteria:

* 5-FU, oxaliplatin, irinotecan or Metformin Allergic history
* Lactic acidosis, metabolic acidosis
* active infection or severe neuropathy

Primary outcomes:
measure: Disease Control Rate
timeFrame: one year
Secondary outcomes:
measure: Response Rate
timeFrame: one year
measure: Overall Survival
timeFrame: one year
measure: Number of participants with adverse events
timeFrame: one year
measure: Progression Free Survival
timeFrame: one year
Other outcomes:
Locations:
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
Study officials:
References:
Clinical trial NCT03286569: Study the Effect of Upper Expansion Appliances on Lower Jaw Forward Projection/Growth
Official title: Study the Effect of Upper Expansion Appliances on Lower Jaw Forward Projection/Growth
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Overbite (Excessive) Horizontal
Lead sponsor: University of Alberta
Sponsor class: OTHER
First posted: 2017-09-18
Enrollment: 60
Sex: ALL
Minimum age (years): 9
Maximum age (years): 11
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Young children with backward positioned lower jaw/chin will be recruited to have an upper jaw expansion appliance. Previous research showed that the use of similar appliances can lead to lower jaw forward growth. 60 young children aged 9-11 will be recruited to have either active or non-active Wilson type upper arch expansion appliance. Patients will have special x-ray (Cone Beam computed tomography) before and after treatment (after 9 months) of starting the treatment. After participation, routine orthodontic treatment will be continued.

Detailed description: Previous research showed that the use of upper jaw expansion appliances can lead to lower jaw forward growth (1). 60 young children aged 9-11 with backward positioned lower jaw/chin will be recruited to have either active or non-active Wilson type upper arch expansion appliance. Patients will have special x-ray (Cone Beam computed tomography) before and after treatment (after 9 months) of starting the treatment. After participation, routine orthodontic treatment will be continued.

Eligibility criteria: Inclusion Criteria:

1. Class II skeletal due to lower jaw backward projection
2. Class II malocclusion
3. Early mixed dentition (all first permanent molars erupted, as well as all erupting upper and lower permanent incisors)

Exclusion Criteria:

1. Other orthodontic treatment provided
2. Growth problems (craniofacial syndromes, etc.)

Primary outcomes:
measure: Lower jaw size
timeFrame: 9 months
measure: Lower jaw projection
timeFrame: 9 months
Secondary outcomes:
measure: Jaw joint size
timeFrame: 9 months
measure: Base of skull bone size
timeFrame: 9 months
measure: Base of skull bone position
timeFrame: 9 months
measure: Jaw joint position
timeFrame: 9 months
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: University of Alberta
state: Alberta
Study officials:
References:
citation: McNamara JA Jr, Sigler LM, Franchi L, Guest SS, Baccetti T. Changes in occlusal relationships in mixed dentition patients treated with rapid maxillary expansion. A prospective clinical study. Angle Orthod. 2010 Mar;80(2):230-8. doi: 10.2319/040309-192.1.
citation: Guest SS, McNamara JA Jr, Baccetti T, Franchi L. Improving Class II malocclusion as a side-effect of rapid maxillary expansion: a prospective clinical study. Am J Orthod Dentofacial Orthop. 2010 Nov;138(5):582-91. doi: 10.1016/j.ajodo.2008.12.026.
Clinical trial NCT00309569: Randomized Study Comparing Pre- and Postoperative vs. Conventional Adjuvant Treatment in Receptor-negative Patients
Official title: A Randomized Phase III Study Comparing Pre- and Postoperative vs. Conventional Adjuvant Treatment Hormone Receptor-negative Breast Cancer Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Early Stage Breast Cancer
Keywords: Cyclophosphamide
Methotrexate
Fluorouracil
Epirubicine
Breast Cancer
Lead sponsor: Austrian Breast & Colorectal Cancer Study Group
Sponsor class: NETWORK
First posted: 2006-04-03
Enrollment: 429
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Primarily, this clinical investigation compared overall survival and recurrence-free survival in patients with hormone receptor-negative breast cancer treated with pre- and postoperative chemotherapy vs. conventional postoperative treatment.


Eligibility criteria: Inclusion Criteria:

* Patients with bioptically verified breast cancer
* Estrogen receptor-negative status
* Age: \< 70 years
* WHO Performance Status \< 2
* Laboratory parameters

  1. hematopoiesis: \> 3500/mm3 leukocytes, \> 100,000/mm3 thrombocytes
  2. renal function: creatinin \< 1.5mg%
  3. hepatic function: GOT max. 2.5 x UNL
  4. bilirubin: \< 2.0 mg %
  5. metabolic parameters: Na, Ca, K in normal range
* \</= 4 weeks interval since surgery
* Informed consent

Exclusion Criteria:

* Patients with locally inoperable cancer, M1
* Other preoperative tumor-specific radiotherapy, chemotherapy or endocrine treatment
* Pregnancy or lactation
* General contraindication against cytostatic treatment
* T4 cancer; inflammatory disease, simultaneous or sequential bilateral breast cancer
* Lacking compliance or understanding of disease
* Serious concomitant disease
* Second carcinoma or status post second carcinoma (except for treated squamous cell carcinoma of the skin or cervical carcinoma in situ)

Primary outcomes:
measure: Overall survival
measure: Recurrence-free survival
Secondary outcomes:
measure: Rate of breast-conserving procedures
Other outcomes:
Locations:
Study officials:
affiliation: Austrian Breast & Colorectal Cancer Study Group
name: Raimund Jakesz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03997669: The Diagnosis and Mechanism of Pleural Effusion
Official title: The Diagnosis and Mechanism of Pleural Effusion
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pleural Diseases
Lead sponsor: Wuhan Union Hospital, China
Sponsor class: OTHER
First posted: 2019-06-25
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with pleural effusion

Brief summary: The diagnosis, treatment and mechanism of pleural diseases

Detailed description: The diagnosis and treatment of benign and malignant pleural effusions, the mechanisms of pleural diseases

Eligibility criteria: Inclusion Criteria:

Patients with pleural effusion, who has not been treated

Exclusion Criteria:

Patients with pleural effusion, who has already been treated

Primary outcomes:
measure: overall survival
timeFrame: 1 years
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Jinshuo Fan
state: State...
Study officials:
affiliation: Key Laboratory of Respiratory Diseases of the Ministry of Health
name: Jinshuo Fan, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03168269: Can CCTA Technicians Provide Accurate Interpretation of Findings in Patients Presenting to the ED in After Hours?
Official title: Can CCTA Technicians Provide Accurate Interpretation of Findings in Chest Pain Patients Presenting to the Emergency Department in After Hours?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
Keywords: CCTA interpretation
technicians
experts
comparison
Lead sponsor: Jordan Collaborating Cardiology Group
Sponsor class: OTHER
First posted: 2017-05-30
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients referred from the ED or outpatient service for elective CCTA to rule out CAD

Brief summary: Coronary Computed Tomographic Angiography (CCTA) is emerging as the diagnostic test of choice in chest pain patients with low to intermediate probability of coronary artery disease (CAD). Qualified CCTA readers may not be available around the clock in most centers, limiting the use of CCTA. This study aimed to determine if well-qualified CCTA technicians can provide initial accurate diagnosis to guide initial management and triage of such patients


Eligibility criteria: Inclusion Criteria:

* All patients referred for elective CCTA to assess coronary artery disease

Exclusion Criteria:

* Patients with previous coronary revascularization procedures (PCI or CABG).

Primary outcomes:
measure: The agreements between the two technicians and the cardiologist in evaluation of coronary segments
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05383469: Efficacy of Active Versus Passive Methods in Chronic Venous Insufficiency
Official title: Comparison of the Efficacy of Active Versus Passive Methods in Patients With Chronic Venous Insufficiency
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Venous Insufficiency
Keywords: exercise
compression
neuromuscular electrical stimulation
massage
Lead sponsor: Istanbul University - Cerrahpasa
Sponsor class: OTHER
First posted: 2022-05-20
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of our study was to compare the effectiveness of active and passive practices in patients with CVI.

Detailed description: Volunteers who have been diagnosed with venous insufficiency according to the criteria of inclusion, who applied to Cardiovascular Surgery Department will be included this study.

Participants will be randomly allocated 3 groups using the 'Research Randomizer' website. In all groups, a common evaluation protocol will be applied to the patients.

Compression therapy will be applied to the first group. Active treatment in addition to compression therapy will be applied to the second group. Passive treatment in addition to compression therapy will be applied to the third group.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of venous insufficiency with duplex ultrasonography
* Classification of CEAP (Clinical-Etiological-Anatomical-Pathological) used in venous insufficiency is C3-C4-C5-C6
* Ankle-brachial index (ABI) is less than 0.7
* Possibility to communicate in written and verbal in Turkish
* Have a level of cognitive ability to understand the instructions given

Exclusion Criteria:

* Presence of deep vein thrombosis
* Ulceration or open burn wound in lower extremity greater than 4 cm
* Presence of infected ulceration
* Cardiorespiratory insufficiency
* Orthopedic, rheumatologic or neurological comorbidities restrain the exercise in the lower extremity
* Presence of a psychiatric illness requiring the use of prescribed medicines

Primary outcomes:
measure: Circumference measurements
timeFrame: Change from Baseline circumferences at 8 weeks.
Secondary outcomes:
measure: Visual Analogue Scale (VAS)
timeFrame: Assessment will be performed at baseline and at 8 weeks.
measure: Venous Clinical Severity Score (VCSS)
timeFrame: Assessment will be performed tat baseline and at 8 weeks.
measure: Handheld Dynamometer
timeFrame: Assessment will be performed at baseline and at 8 weeks.
measure: 6-Minute Walking Test
timeFrame: Assessment will be performed at baseline and at 8 weeks.
measure: 10-Meter Walking Test
timeFrame: Assessment will be performed at baseline and at 8 weeks.
measure: Chronic Venous Disease Quality of Life Questionnaire (CIVIQ) 20
timeFrame: Assessment will be performed at baseline and at 8 weeks.
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul University-Cerrahpasa
state: Büyükçekmece
Study officials:
References:
Clinical trial NCT05490069: The Effect of Instant Message Intervention for Psychological Well-being Among Stroke Survivors
Official title: The Effect of Instant Message Intervention for Psychological Well-being Among Stroke Survivors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Depressive Symptoms
Mobile Phone Use
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2022-08-05
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The proposed pilot trial aims to evaluate the feasibility of iCBT based EMI, which is a real-time, real-world, personalised and cost-effective approach, for stroke survivors' psychological well-being.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of stroke (ICD-10 codes: I60-I69)
* Aged ≥18
* Able to read and communicate in Chinese (Cantonese or Putonghua)
* Able to use text messaging function on mobile phones
* MoCA 5-minute Protocol (cognitive screen) ≥14 (Equivalence to MMSE ≥ 21)
* Discharged home from hospital within preceding 6 months
* PHQ-9 (depressive symptom) score range from 5 to 19 (cf. mild: 5-9, moderate: 10-14, moderately severe: 15-19 and severe: 20-27)

Exclusion Criteria:

* Currently receiving active stroke care in acute or post-acute inpatient settings
* Has diagnosis of psychiatric disease or is currently taking psychotropic drug
* PHQ-9 ≥ 20 (i.e., severe depressive symptom)
* Currently participating in any type of psychological intervention (e.g., CBT)

Primary outcomes:
measure: Depressive symptoms (Patient Health Questionnaire-9 [PHQ-9])
timeFrame: 24-week
Secondary outcomes:
measure: Anxiety symptoms (Generalized Anxiety Disorder-7 [GAD-7])
timeFrame: 24-week
measure: Stress level (Perceived Stress Scale [PSS-4])
timeFrame: 24-week
measure: Spiritual well-being (Sub-scale of Spirituality Scale for Chinese Elders [SSCE])
timeFrame: 24-week
measure: Loneliness (UCLA Loneliness Scale [ULS-8])
timeFrame: 24-week
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Hong Kong PHAB Association
city: Hong Kong
country: Hong Kong
facility: Hong Kong Stroke Association
city: Hong Kong
country: Hong Kong
facility: NT West Community Rehabilitation Day Centre
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
city: Hong Kong
country: Hong Kong
facility: The Hong Kong Society for Rehabilitation
city: Hong Kong
country: Hong Kong
facility: Tung Wah Hospital
city: Hong Kong
country: Hong Kong
facility: United Christian Hospital
Study officials:
References: