louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03860103: Placental Insufficiency Microcirculation Quantification by Ultrafast Doppler (MICRODOPPLER PLACENTA)
Official title: Placental Insufficiency Microcirculation Quantification by Ultrafast Doppler: an Observational Prospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Preeclampsia and Intrauterine Growth Restriction
Keywords: microDoppler
placenta
preeclampsia
intrauterine growth restriction
Lead sponsor: Nantes University Hospital
Sponsor class: OTHER
First posted: 2019-03-01
Enrollment: 165
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pregnant women

Brief summary: To identify fetuses small for their gestational-age who have reached their appropriate growth potential from growth-restricted fetuses due to placental insufficiency is uneasy. Intra Uterine Growth Restriction (IUGR) increases the risk for indicated preterm delivery, neonatal mortality and morbidity. Therefore, improving the knowledge of the placental perfusion is essential to better identify and manage fetal chronic oxygen deprivation associated with placental insufficiency. Thus, the investigators propose to study placental microcirculation with a more efficient Doppler than conventional Doppler use in clinical practice. The Ultrafast Doppler is being able to map placental blood flow and could have potential impact in placental insufficiency diagnosis and prevention. Moreover, this Doppler could discriminate maternal and fetal vascularization.

The hypothesis is that Ultrafast Doppler could help clinician to diagnose and manage preeclampsia and IUGR during pregnancy.


Eligibility criteria: Inclusion Criteria:

* Patient who accepted to participate in the study
* Woman over 18 years old
* Affiliated to a social security scheme
* Mono-fetal pregnancy
* Patients with normal pregnancy between 11 and 42 weeks of amenorrhea
* Patients hospitalized for preeclampsia and / or intrauterine growth retardation, beyond 20 weeks of amenorrhea

Exclusion Criteria:

* Minors, adults under guardianship, protected persons
* Not affiliated to a social security scheme
* Multiple pregnancy

Primary outcomes:
measure: Qualitative analysis (velocities) of intraplacental blood flow after acquisition of sequences in Ultrafast Doppler imaging
timeFrame: from the 12 week of gestation
measure: Quantitative analysis (flow rates) of intraplacental blood flow after acquisition of sequences in Ultrafast Doppler
timeFrame: from the 12 week of gestation
Secondary outcomes:
Other outcomes:
Locations:
city: Nantes
country: France
facility: Nantes University Hospital
Study officials:
References:
Clinical trial NCT05348603: Electronic Health Record Strategies to Promote Diverse Participation in Research
Official title: Leveraging Community Engagement and Electronic Health Record Strategies to Promote Diverse Participation in Clinical Research
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Patient Participation
Keywords: Online Patient Portal
Lead sponsor: Yale University
Sponsor class: OTHER
Collaborators: name: Food and Drug Administration (FDA)
First posted: 2022-04-27
Enrollment: 726199
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Intervention model description: To examine the effectiveness of enhanced online patient portal features in increasing interest and participation in clinical trials, a randomized trial that will employ a full 2X2X2X2 factorial design.
Primary purpose: OTHER

Brief summary: The purpose of this study is to determine the effectiveness of enhanced features in an online patient portal including banners, a chatbot, and direct to patient message and traditional mailed letters on increasing interest in research among online patient portal users.

Detailed description: The primary objective is to examine the effectiveness of enhanced online patient portal features including banners, a chatbot, and direct to patient message and traditional mailed letters on increasing interest in research among online patient portal users, as measured by the user's creation of a research profile.

The secondary objective is to examine the effectiveness of two enhanced online patient portal features including banners, a chatbot and direct-to-patient messages and traditional mailed letters on increasing participation in research among online patient portal users, as measured by the user joining a research study.

This study tests the hypothesis that at one year follow-up, various user engagement tools (e.g. messaging, banners) will increase the proportion of research profiles created by online patient portal users over profiles created by online patient portal users in the absence of those interventions.

Eligibility criteria: Inclusion Criteria:

* Has an account with the online patient portal
* Has logged into the online patient portal at least once in the past year
* Has not set up a research profile

Exclusion Criteria:

* Currently enrolled in a clinical trial
* Opted out of research
* Has received a direct to patient recruitment message within the past year
* On active cancer treatment
* Active member of the study team

Primary outcomes:
measure: Number of patients who create a research profile
timeFrame: 12 months
Secondary outcomes:
measure: Number of patients who enroll in a research study
timeFrame: 12 months
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Yale University
state: Connecticut
Study officials:
affiliation: Yale University
name: Brian Smith, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04988503: Bare Platinum Coils Versus Second-generation Hydrocoils
Official title: Bare Platinum Coils Versus Second-generation Hydrocoils for the Endovascular Treatment of Ruptured Intracranial Aneurysms: a Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Aneurysm, Ruptured
Intracranial Aneurysm
Keywords: aneurysms
embolization
rupture
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: Pusan National University Yangsan Hospital
name: Chungnam National University Sejong Hospital
First posted: 2021-08-03
Enrollment: 118
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: bare platinum coils group versus second-generation hydrogel coil group
Primary purpose: TREATMENT

Brief summary: Comparison of clinical and radiological outcomes between bare platinum coil group and second-generation hydrogel coils for treatment of ruptured intracranial aneurysms.

Detailed description: The investigators aimed to analyze whether the use of second-generation hydrogel coils for the treatment of ruptured intracranial aneurysms improves clinical and angiographic outcomes compared with the use of bare platinum coils.

Eligibility criteria: Inclusion Criteria:

* 19 year old or older
* untreated ruptured intracranial aneurysms with an anatomy such that endovascular treatment with either bare platinum or second-generation hydrogel coils was considered feasible.
* person who agreed to study

Exclusion Criteria:

* contrast allgery (+)
* combined other intracranial lesions (tumor, moyamoya disease, cerebral vascular diseases)
* ineligible for coil embolization

Primary outcomes:
measure: recurrence rate after treatment
timeFrame: during 12 months after coil embolization
Secondary outcomes:
measure: Rates of thromboembolic and hemorrhagic complications
timeFrame: during 12 months after coil embolization
measure: Rate of periprocedural complications
timeFrame: within 30 days after coil embolization
measure: Assessment of clinical outcomes using modified Rankin Scale scores
timeFrame: during 12 months after coil embolization
Other outcomes:
Locations:
city: Sejong
country: Korea, Republic of
facility: Chungnam National University Sejong Hospital
state: Chungnam
city: Yangsan
country: Korea, Republic of
facility: Pusan National University Yangsan Hospital
state: Gyeongsangnam-do
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
Study officials:
affiliation: Seoul National University Bundang Hospital
name: O-Ki Kwon
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02223403: Effect of Nitrate-rich Beetroot Juice on Exercise Performance in Heart Failure Patients
Official title: Single Dose of Nitrate-rich Beetroot Juice Does Not Improve Steady State Oxygen Consumption or Six-minute Walk Distance in Patients With Systolic Heart Failure.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Systolic Heart Failure
Keywords: Nitrate-rich beetroot juice
heart failure
exercise performance
oxygen consumption
Lead sponsor: Brooke Army Medical Center
Sponsor class: FED
First posted: 2014-08-22
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Nitrate-rich beetroot juice supplementation has demonstrated reduced oxygen consumption and submaximal exercise performance in healthy adults. Investigation for similar effects in patients with heart failure has not previously been conducted.

This was a randomized, double-blind, placebo controlled trial. Following ingestion of the active agent or placebo, subjects with systolic heart failure underwent submaximal steady state exercise with gas exchange analysis followed thirty minutes later by a six minute walk test. Second testing sessions were performed ten days.

There were no significant differences in the treatment and placebo arms in average oxygen consumption or six minute walk distance.

In conclusion, in patients with heart failure who have ingested a single dose of nitrate-rich beetroot juice concentrate, there is no significant difference with regard to oxygen consumption during submaximal steady state exercise or six minute walk testing distance.

Further study is warranted to determine the true efficacy of nitrate consumption in this population with adjustments in acute or chronic dosing, exercise duration, or intensity.


Eligibility criteria: Inclusion Criteria:

* Local institutional beneficiaries between the ages of 18 and 80
* Documentation of left ventricular systolic dysfunction with ejection fraction \< 40% by any modality within the past six months
* Documentation of New York Heart Association class II or III status.

Exclusion Criteria:

* \> 80 years of age
* Unable to adequately or safely perform treadmill exercise
* Pulmonary disease deemed significant enough to be a limitation to exercise
* Greater than moderate stenotic or regurgitant valvular heart disease
* Presence of atrial fibrillation or other uncontrolled arrhythmias
* Uncompensated heart failure
* Continuously paced rhythms
* Pregnant females
* Chronic nitroglycerine use (oral isosorbide di or mono-nitrate, or topical nitroglycerine)
* Phosphodiesterase inhibitor (sildenafil or tadalafil) use within a week

Primary outcomes:
measure: steady state exercise oxygen consumption
timeFrame: 10 minutes
measure: six minute walk distance
timeFrame: six minutes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Brooke Army Medical Center
name: Kenneth M Leclerc, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02034903: Effect of Feed Warming Method on Feeding Tolerance in the Preterm Infant Born at Less Than 30 Weeks Gestation
Official title: Effect of Feed Warming Method on Feeding Tolerance in the Preterm Infant Born at Less Than 30 Weeks Gestation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Enteral Feeding
Keywords: Enteral Feeding
Infant, Premature
Lead sponsor: Advocate Center for Pediatric Research
Sponsor class: OTHER
Collaborators: name: Wake Forest University Health Sciences
name: Medela AG
First posted: 2014-01-14
Enrollment: 86
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The temperature of milk fed to infants in the Neonatal Intensive Care Unit (NICU) has been shown to vary greatly, and is influenced by individual provider practice. The clinical effect of varying milk temperatures on preterm infant feeding tolerance has not been well studied. The purpose of this study is to examine the effect of warming method, water bath versus commercial warmer and its impact on feeding tolerance. Sample population will include eighty-six infants born at 30-0/7 weeks or less, and admitted to the Neonatal Intensive Care Unit at Advocate Children's Hospital, Park Ridge within 48 hours of birth and remain in the study for a minimum of 28 days. After obtaining consent, eligible infants will be assigned to a control (water bath) or experimental (commercial warmer) group using a randomized sampling scheme. After warming, and just prior to feeding, milk temperatures will be taken and recorded by a trained data recorder. Feeding tolerance will be measured based on gastric residual volume and length of time required to achieve full feeds. Based upon the available evidence, the study investigators hypothesize that warming feeds to a consistent temperature range using commercially available milk warmer will improve feeding tolerance and decrease time to full feedings in preterm infants.


Eligibility criteria: Inclusion Criteria:

* Preterm infants born at less than or equal to 30 0/7 weeks gestation
* Infants will be enrolled within the first 48 hours of life

Exclusion Criteria:

* Gastrointestinal anomalies
* Lethal malformations
* Parental denial of consent or request for removal from study

Primary outcomes:
measure: Feeding intolerance
timeFrame: 168 completed feedings; approximately 28 days
Secondary outcomes:
measure: Full enteral feeding
timeFrame: approximately 28 days
Other outcomes:
Locations:
city: Park Ridge
country: United States
facility: Advocate Children's Hospital, Park Ridge
state: Illinois
Study officials:
References:
Clinical trial NCT02809703: Quality of Life Following ECMO
Official title: Assessment of the Long Term Quality of Life Following Veno-venous and Veno-arterial Extracorporeal Membrane Oxygenation (ECMO)
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Extracorporeal Membrane Oxygenation
Quality of Life
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2016-06-22
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who underwent VV or VA ECMO at Duke.

Brief summary: The objective of the study is to determine the quality of life of patients in the years following treatment with extracorporeal membrane oxygenation (ECMO). The study population will include all adults treated with any configuration of ECMO at Duke University Medical Center during the period of Jan 1, 2009 and Dec 31, 2015. Patient's will be contacted by direct mail, in conjunction with a surgeon who performed their ECMO procedure or managed them while on ECMO, and asked to complete a validated survey (WHOQOL-Bref) which assesses quality of life. In addition, patients will be asked to opt-in to participate in a phone survey in which they can give a narrative about their ICU experience and answer specific questions regarding long-term comorbidities. Data will be stored in a secure online server which is HIPAA compliant and analyzed by the department of anesthesiology statistical support services. De-identified data will be shared with the WHO as specified in their usage agreement.


Eligibility criteria: Inclusion Criteria:

* VA or VV ECMO performed during retrospective study period

Exclusion Criteria:

* Pediatric

Primary outcomes:
measure: Quality of Life as Assessed by the WHOQOL-BREF.
timeFrame: 6 months to 5 years post ECMO procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
Study officials:
References:
Clinical trial NCT05450003: Effect of Different Irrigation Activating Techniques on Irrigant Penetration Depth and on Post-Operative Pain
Official title: Effect of Different Irrigation Activating Techniques on Irrigant Penetration Depth Into Root Canals and on Post-Operative Pain After Single-Visit Endodontic Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Irrigation Activation
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2022-07-08
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: the study will evaluate 3 groups of patients each consists of 10 participants receiving different type of irrigation activation.
Primary purpose: TREATMENT

Brief summary: Irrigation activation in endodontics is considered now a very important step for the success of root canal treatment. In this study, the investigator will examine the effect of two recent activation systems ( XP-endo Finisher file and the new sonic EDDY system) in comparison with the conventional needle irrigation on irrigant penetration depth into root canals using radiopaque contrast media and digital radiography and on the postoperative pain after single-visit endodontic treatment using a visual analog scale.


Eligibility criteria: Inclusion Criteria:

* Asymptomatic vital/non vital teeth requiring root canal treatment.
* Teeth with sound periodontal apparatus.
* Teeth without pus or inflammatory exudates draining through the canal.
* Teeth without anatomic variations.
* Teeth with sinus tract.
* Teeth without history of trauma.
* Patients not on analgesics or sedative medication prior to root canal therapy

Exclusion Criteria:

* • Patients with any systemic diseases.

  * Pregnant or lactating patients.
  * Immunocompromised patients.
  * Apparently thin roots in which apical preparation with #40 file would be overzealous.
  * Patient allergic to anything used in this procedure especially rubber dam material and Iohexol (radiographic contrast media).
  * Teeth with calcified canals.
  * Patients with acute apical periodontitis, acute apical abscess, and weeping canals.
  * Necrotic painful teeth with the absence of sinus tract for drainage.

Primary outcomes:
measure: irrigant penetration depth
timeFrame: through study completion, an average of 3 months
measure: postoperative pain
timeFrame: through study completion, an average of 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Faculty of Dentistry, Tanta University
Study officials:
References:
Clinical trial NCT00270803: The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana
Official title: The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Marijuana Dependence
Keywords: Marijuana, FDG, PET, maze, THC, motor coordination.
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
Collaborators: name: Hadassah Medical Organization
First posted: 2005-12-28
Enrollment: 12
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana.On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG).

Detailed description: This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana. On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG). 12 subjects were tested so far on both conditions.

Eligibility criteria: Inclusion Criteria:

* Marijuana dependence
* Age 20-65
* Male and female

Exclusion Criteria:

* Pregnant women
* Dependence on other substances
* Psychiatric diagnosis apart from marijuana dependence
* Neurological disorder
* Young persons

Primary outcomes:
measure: Brain metabolic activity (FDG)
timeFrame: 30-40 minutes
Secondary outcomes:
measure: Reaction time (RTs) and errors in performance
timeFrame: 40 minutes
measure: Subjective ratings on visual analog scale
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Tel Aviv
country: Israel
facility: Department of Nuclear Medicine
Study officials:
affiliation: Sourasky Medical Center
name: Aviv M Weinstein, Ph.D
role: PRINCIPAL_INVESTIGATOR
affiliation: Sourasky Medical Center
name: Einat Even-Sapir, M.D. Ph.D
role: PRINCIPAL_INVESTIGATOR
References: