Clinical trial NCT03182543: Physiological Effect of Ataulfo Mango (Manguifera Indica) Beverage in Exercise
Official title: Physiological Response to Ataulfo Mango Pulp and Peel Beverages in Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise-induced Oxidative Stress
Keywords: Exercise
Oxidative stress
Antioxidant
Lead sponsor: Universidad Autonoma de Ciudad Juarez
Sponsor class: OTHER
First posted: 2017-06-09
Enrollment: 19
Sex: MALE
Minimum age (years): 17
Maximum age (years): 28
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: The prescription of the treatments (AM1, AM2) and control (water) was randomized. The subject consumed 600mL of AM1, AM2 or water. 2 hours later subject performed the exercise test. Next treatment was evaluated after a week of wash-out.
Primary purpose: PREVENTION

Brief summary: The aim of this study is to assess the antioxidant capacity of two mango base beverages (AM1, AM2), against exercise-induced oxidative stress.

Detailed description: Introduction. The post-consumption physiological effect of mango cv. "Ataulfo" pulp (MP) and peel (MC) in humans before exercise has been poorly evaluated.

Objective. To evaluate the physiological response, to consumption of two mango base beverages, AM1 (200g MP/ 600mL water) and AM2 (160g MP; 40g MC / 600mL water), before and after a submaximal exercise test.

Methods. The antioxidant profile and physicochemical characteristics of AM1 and AM2 were evaluated. Several cardiorespiratory, anthropometric and body composition parameters of 19 university students, prior to the consumption of AM1, AM2 and water, were evaluated in three non-consecutive sessions (self-control cases). The glycemic, lactic and antioxidant (FRAP), uric acid (AU), reduced glutathione (GSH) and lipid oxidation (TBARS) and protein carbonyls (PC) responses were evaluated in plasma before and after an incremental cycle ergometer exercise test.

Eligibility criteria: Inclusion Criteria:

* healthy male
* university student
* no alcohol, cigar or drugs consumption

Exclusion Criteria:

* no antioxidant supplement or ergogenic consumption
* health issues with performing physical activity

Primary outcomes:
measure: Antioxidant capacity change
timeFrame: 0 min (before beverage intake), 9-15 min (immediately after exercise test)
measure: Antioxidant capacity change
timeFrame: 0 min (before beverage intake), 9-15 (immediately after exercise test)
measure: Antioxidant capacity change
timeFrame: 0 min (before beverage intake), 9-15 (immediately after exercise test)
Secondary outcomes:
measure: Oxidative stress change
timeFrame: 0 min (before beverage intake), 9-15 (immediately after exercise test)
measure: Oxidative stress change
timeFrame: 0 min (before beverage intake), 9-15 (immediately after exercise test)
measure: Lactic acid concentration change
timeFrame: 0 min (before performing exercise test), 3 min, 6 min, 9 min, 12 min, 15 min (during exercise test)
measure: Postprandial glycemic change
timeFrame: 0 min (before beverage intake), 30 min, 60 min, 90 min, 120 min (after beverage intake)
Other outcomes:
Locations:
Study officials:
affiliation: Universidad Autónoma de Ciudad Juárez
name: Abraham Wall-Medrano, PhD
role: STUDY_DIRECTOR
affiliation: Universidad Autónoma de Ciudad Juárez
name: Gregorio Chavez-Treviño, MS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Alvarez-Parrilla E, De La Rosa LA, Legarreta P, Saenz L, Rodrigo-Garcia J, Gonzalez-Aguilar GA. Daily consumption of apple, pear and orange juice differently affects plasma lipids and antioxidant capacity of smoking and non-smoking adults. Int J Food Sci Nutr. 2010 Jun;61(4):369-80. doi: 10.3109/09637480903514041.
citation: Ramos-Jimenez A, Hernandez-Torres RP, Wall-Medrano A, Torres-Duran PV, Juarez-Oropeza MA, Solis Ceballos JA. Acute physiological response to indoor cycling with and without hydration; case and self-control study. Nutr Hosp. 2013 Sep-Oct;28(5):1487-93. doi: 10.3305/nh.2013.28.5.6698.
citation: Spirlandeli AL, Deminice R, Jordao AA. Plasma malondialdehyde as biomarker of lipid peroxidation: effects of acute exercise. Int J Sports Med. 2014 Jan;35(1):14-8. doi: 10.1055/s-0033-1345132. Epub 2013 Jun 14.
citation: Wang CY, Haskell WL, Farrell SW, Lamonte MJ, Blair SN, Curtin LR, Hughes JP, Burt VL. Cardiorespiratory fitness levels among US adults 20-49 years of age: findings from the 1999-2004 National Health and Nutrition Examination Survey. Am J Epidemiol. 2010 Feb 15;171(4):426-35. doi: 10.1093/aje/kwp412. Epub 2010 Jan 15.
citation: Wall-Medrano A, Olivas-Aguirre FJ, Velderrain-Rodriguez GR, Gonzalez-Aguilar A, de la Rosa LA, Lopez-Diaz JA, Alvarez-Parrilla E. [Mango: agroindustrial aspects, nutritional/functional value and health effects]. Nutr Hosp. 2014 Nov 1;31(1):67-75. doi: 10.3305/nh.2015.31.1.7701. Spanish.