Clinical trial NCT02221050: Hemodialysis and Wanting for Protein-rich Foods
Official title: Influence of Chronic Renal Failure and Hemodialysis on Liking and Wanting for Foods
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Renal Failure
Lead sponsor: University of Burgundy
Sponsor class: OTHER
First posted: 2014-08-20
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: hemodialysis centers of Clinique Drevon, Dijon, France la Breuchillière, Saint Apollinaire, France University Hospital, Dijon, France Macon Hospital, Macon, France

Brief summary: A study conducted in the laboratory revealed the existence of a "window" during which patients with renal failure appreciate the protein-rich foods. This period, located immediately after the dialysis, is likely related to the purification of plasma products resulting from protein catabolism. It therefore appears necessary to understand the mechanisms that may explain these changes by measurements of ghrelin (orexigenic hormone), leptin (anorectic hormone) and plasma amino acids.

Detailed description: In 24 patients with renal failure treated by hemodialysis, it is evaluated (at 8:00 am and at 11:00 am), a day without hemodialysis and another day after the hemodialysis:

* Hunger sensation,
* Olfactory liking assessed separately for 6 foods (2 carbohydrate-, 2 fat- and 2 protein-rich foods) and 2 non-alimentary products,
* Food wanting evaluated by the sequential presentation of 18 images of food (6 fat-, 6 carbohydrate- and 6 protein-rich foods),
* Two blood samples for the assays of leptin, ghrelin, creatinine, albumin and pre-albumin as well as plasma amino acids.

  24 healthy subjects are also evaluated in order to compare the results from patients to those of control subjects.

Eligibility criteria: Inclusion Criteria:

* Patients and healthy subjects were included if they were aged between 18 and 80 years

Exclusion Criteria:

* diabetes, advanced undernutrition (BMI \< 17.5 kg m-2, prealbumin \< 250 mg.L-1), congestive heart failure, acute or chronic infection, ongoing antibiotic treatment, active cancer, liver cirrhosis, smoking (more than 5 cigarettes/day), alcohol consumption (more than 3 units/day), aversion to the foods eaten or smelt during the study, impaired comprehension of the cognitive tasks

Primary outcomes:
measure: Amount of wanting for protein-rich foods
timeFrame: 20 min (from 8:00 to 8:20 am) and 20 min (from 11:00 to 11:20 am)
Secondary outcomes:
measure: Concentrations of the plasma amino-acids
timeFrame: 8:30 am and 11:30 am
Other outcomes:
Locations:
city: Dijon
country: France
facility: Centre des Sciences du Goût
state: Burgundy
Study officials:
affiliation: Centre des Sciences du Goût, Centre National de la recherche Scientifique
name: Luc PENICAUD, PHD
role: STUDY_DIRECTOR
References:
citation: Mouillot T, Filancia A, Boirie Y, Brindisi MC, Hafnaoui N, Van Wymelbeke V, Teillet E, Meintani I, Jacquin-Piques A, Leloup C, Penicaud L, Mousson C, Brondel L. Hemodialysis Affects Wanting and Spontaneous Intake of Protein-Rich Foods in Chronic Kidney Disease Patients. J Ren Nutr. 2021 Mar;31(2):164-176. doi: 10.1053/j.jrn.2020.05.006. Epub 2020 Jul 25.