Clinical trial NCT01384669: Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis
Official title: Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Papillary Thyroid Microcarcinoma
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2011-06-29
Enrollment: 29
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who were diagnosed as papillary thyroid microcarcinoma with or without lateral neck node metastasis

Brief summary: In this study, the investigators look at the genetic expressional alteration which influenced on the early lateral neck node metastasis in thyroid papillary microcarcinoma.

Detailed description: Papillary thyroid carcinomas (PTCs) measuring 1.0 cm or less in diameter were defined as papillary thyroid microcarcinomas (PTMCs) by the World Health Organization (WHO), emphasizing on their benign behavior, probably of little clinical significance, which do not affect patients' survival. However, some reported that PTMCs may have aggressive behavior, can cause locoregional recurrences, cervical lymph node metastases, and even distant metastases. But till now, the characteristics of PTMCs with early lateral neck node metastasis were only reviewed and described by the clinicopathological parameters, and no analysis of PTMCs by the gene level is available. In these study, we investigate the genetic expressional alteration which influenced on the early lateral neck node metastasis in thyroid papillary microcarcinoma.

Eligibility criteria: Inclusion Criteria:

* age≥20 years old
* Conventional type papillary thyroid microcarcinoma (0.5cm≤tumor size≤1.0cm)
* group 1: no lymph node metastasis /group 2: with lateral neck node metastasis

Exclusion Criteria:

* tumor with capsular invasion (T3 tumor)
* distant metastasis
* combined underlying thyroiditis

Primary outcomes:
measure: mRNA expression pattern by microarray analysis
timeFrame: 24-hour after surgical removement
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
Study officials:
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