Clinical trial NCT01690364: Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery
Official title: Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Motor Evoked Potential Monitoring
General Anesthesia
Neurosurgery
Brain Tumor
Spine Tumor
Cerebral Aneurysm
Keywords: Motor evoked potential monitoring
General Anesthesia
Neurosurgery
Cisatracurium
Vecuronium
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2012-09-21
Enrollment: 74
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce neural damage during neurosurgery.

As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial NMB is usually maintained during general anesthesia. Continuous infusion of NMB agent is preferred than bolus infusion during MEP monitoring. There are a lot of NMB agents in clinical use. But there have been no reports about the effect of changing NMB agent on efficacy of MEP monitoring.

Therefore, the investigators performed a randomized controlled trial to evaluate the effect of changing NMB agent on the variability of MEP amplitude during neurosurgery.

Detailed description: Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce neural damage during neurosurgery.

As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial NMB is usually maintained during general anesthesia. Continuous infusion of NMB agent is preferred than bolus infusion during MEP monitoring. There are a lot of NMB agents in clinical use. But there have been no reports about the effect of changing NMB agent on efficacy of MEP monitoring.

Therefore, the investigators performed a randomized controlled trial to evaluate the effect of changing NMB agent on the variability of MEP amplitude during neurosurgery.

Eligibility criteria: Inclusion Criteria:

* Adult patients undergoing neurosurgery with intraoperative motor evoked potential monitoring

Exclusion Criteria:

* Patients who can not undergo motor evoked potential monitoring due to central or peripheral neuromuscular disease (e.g. Cerebral palsy, Myasthenia gravis, Acute spinal injury, neurologic shock)
* Patients with hepatic or renal disease with altered metabolism of vecuronium
* Patients with medication which influence the metabolism of vecuronium (e.g. calcium channel blocker, aminoglycoside antibiotics, Lithium, MgSO4)

Primary outcomes:
measure: MEP amplitude
timeFrame: 15 min after anesthetic induction
measure: MEP amplitude
timeFrame: 30 min after anesthetic induction
measure: MEP amplitude
timeFrame: 45 min after anesthetic induction
measure: MEP amplitude
timeFrame: 60 min after anesthetic induction
measure: MEP amplitude
timeFrame: 75 min after anesthetic induction
measure: MEP amplitude
timeFrame: 90 min after anesthetic induction
measure: MEP amplitude
timeFrame: 105 min after anesthetic induction
measure: MEP amplitude
timeFrame: 120 min after anesthetic induction
measure: MEP amplitude
timeFrame: 135 min after anesthetic induction
measure: MEP amplitude
timeFrame: 150 min after anesthetic induction
measure: MEP amplitude
timeFrame: 165 min after anesthetic induction
measure: MEP amplitude
timeFrame: 180 min after anesthetic induction
measure: MEP amplitude
timeFrame: 195 min after anesthetic induction
measure: MEP amplitude
timeFrame: 210 min after anesthetic induction
measure: MEP amplitude
timeFrame: 225 min after anesthetic induction
measure: MEP amplitude
timeFrame: 240 min after anesthetic induction
measure: MEP amplitude
timeFrame: 255 min after anesthetic induction
measure: MEP amplitude
timeFrame: 270 min after anesthetic induction
measure: MEP amplitude
timeFrame: 285 min after anesthetic induction
measure: MEP amplitude
timeFrame: 300 min after anesthetic induction
Secondary outcomes:
measure: Coefficient of variation (CV) of MEP amplitude
timeFrame: at the end of the surgery (5H after the start of surgery)
measure: Average of MEP amplitudes
timeFrame: at the end of the surgery (5H after the start of surgery)
measure: The frequency of adjusting the infusion dose of muscle relaxant
timeFrame: at the end of the surgery (5H after the start of surgery)
measure: Average of Latency of MEP amplitude
timeFrame: at the end of the surgery (5H after the start of surgery)
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
References: