Clinical trial NCT01566721: A Safety and Tolerability Study of Assisted and Self-Administered Subcutaneous (SC) Herceptin (Trastuzumab) as Adjuvant Therapy in Early Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer
Official title: A Phase III Prospective, Two-Cohort Non-Randomized, Multi-Centre, Multinational, Open-Label Study to Assess the Safety of Assisted- and Self-Administered Subcutaneous Trastuzumab as Therapy in Patients With Operable HER2-Positive Early Breast Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Breast Neoplasms
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2012-03-29
Enrollment: 2577
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This multicenter, two-cohort, non-randomized, open-label study will evaluate the safety and tolerability of assisted and self-administered SC Herceptin as adjuvant therapy in participants with early HER2-positive breast cancer following tumor excision. Participants will receive Herceptin 600 milligrams (mg) SC every 3 weeks for 18 cycles, either by an assisted administration using a conventional syringe and needle/vial formulation (Cohort A) or with assisted and self-administration using a single-use injection device (SID) in selected participants (Cohort B).


Eligibility criteria: Inclusion Criteria:

* Histologically confirmed early invasive HER2-positive carcinoma of the breast with no evidence of residual, locally recurrent, or metastatic disease and defined as clinical Stage I to IIIC that is eligible for treatment with Herceptin
* Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
* Screening left ventricular ejection fraction (LVEF) greater than or equal to (≥) 55%

Exclusion Criteria:

* Previous neoadjuvant or adjuvant breast cancer treatment with an approved or investigational anti-HER2 agent
* History of other malignancy except for curatively treated carcinoma in situ of the cervix, basal cell carcinoma, or curatively treated malignancies (other than breast cancer) where the participant has been disease-free for at least 5 years
* Past history of ductal carcinoma in situ treated with any systemic therapy or with radiation therapy to the ipsilateral breast where invasive cancer subsequently developed
* Metastatic disease
* Inadequate bone marrow, hepatic, or renal function
* Serious cardiac or cardiovascular disease including uncontrolled hypertension or history of hypertensive crisis or hypertensive encephalopathy
* History of severe allergic or immunological reactions, such as difficult-to-control asthma
* Pregnant or lactating women

Primary outcomes:
measure: Percentage of Participants With At Least 1 Adverse Event (AE) During the Treatment Period
timeFrame: From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)
measure: Percentage of Participants With a Grade 3 or Higher AE During the Treatment Period
timeFrame: From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)
measure: Percentage of Participants With Treatment Interruption Due to an AE
timeFrame: From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)
measure: Number of Herceptin Cycles Received
timeFrame: From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)
measure: Percentage of Participants by Total Number of Herceptin Cycles Received
timeFrame: From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)
measure: Percentage of Participants Who Received Concomitant Cancer Therapy
timeFrame: From Baseline to data cutoff of 10 March 2015 (up to approximately 3 years)
measure: Percentage of Participants Who Received Concomitant Non-Cancer Therapy
timeFrame: From Baseline to data cutoff of 10 March 2015 (up to approximately 3 years)
Secondary outcomes:
measure: Percentage of Participants Who Died by Data Cutoff of 10 March 2015
timeFrame: From Baseline to time of event (maximum follow-up approximately 3 years as of data cutoff of 10 March 2015)
measure: Percentage of Participants Who Died During the Safety Follow-up Period
timeFrame: From Baseline to Time of Event, Safety Follow-Up Period (Up to 6 Years)
measure: Disease-Free Survival Rate
timeFrame: From Baseline to time of event (up to approximately 8 years)
measure: Overall Survival Rate
timeFrame: From Baseline to Time of Event (Up to Approximately 6 Years)
measure: Percentage of Participants by Item Response to SID Satisfaction Questionnaire
timeFrame: Cycle 4 (cycle length 3 weeks) and last safety follow-up (LSFU) (approximately 1 year)
Other outcomes:
Locations:
city: Tirana
country: Albania
facility: University "Mother Theresa" Hospital Center; Oncology Department
city: Algiers
country: Algeria
facility: CPMC; Service d'Oncologie Médicale
city: Buenos Aires
country: Argentina
facility: Fundación CENIT para la Investigación en Neurociencias
city: Buenos Aires
country: Argentina
facility: Hospital Britanico; Oncologia
city: Zarate
country: Argentina
facility: Instituto De Investigaciones Clinicas Zarate
city: Camperdown
country: Australia
facility: Chris O'Brien Lifehouse
state: New South Wales
city: Kogarah
country: Australia
facility: St George Hospital; Cancer Care Centre
state: New South Wales
city: Randwick
country: Australia
facility: Prince of Wales Hospital; Oncology
state: New South Wales
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital; Division of Cancer Services
state: Queensland
city: Woodville South
country: Australia
facility: Queen Elizabeth Hospital; Medical Oncology
state: South Australia
city: Footscray
country: Australia
facility: Western Hospital
state: Victoria
city: Frankston
country: Australia
facility: Peninsula and South Eastern Haematology and Oncology Group
state: Victoria
city: Malvern
country: Australia
facility: Cabrini Medical Centre; Oncology
state: Victoria
city: Perth
country: Australia
facility: Royal Perth Hospital; Department of Medical Oncology
state: Western Australia
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Center of the Republic of Srpska
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinic of Oncology, University Clinical Center Sarajevo
city: Salvador
country: Brazil
facility: Hospital Sao Rafael - HSR
state: BA
city: Salvador
country: Brazil
facility: Centro de Oncologia da Bahia - CENOB
state: BA
city: Porto Alegre
country: Brazil
facility: Hospital Moinhos de Vento
state: RS
city: Jau
country: Brazil
facility: Hospital Amaral Carvalho
state: SP
city: Sao Paulo
country: Brazil
facility: Instituto do Cancer do Estado de Sao Paulo - ICESP
state: SP
city: Sao Paulo
country: Brazil
facility: Hospital Perola Byington
state: SP
city: Plovdiv
country: Bulgaria
facility: Complex Oncology Center - Plovdiv First Internal Chemotherapy Department
city: Sofia
country: Bulgaria
facility: MHAT Serdika; Department of medical oncology
city: Sofia
country: Bulgaria
facility: SHATOD - Sofia
city: Edmonton
country: Canada
facility: Cross Cancer Institute ; Dept of Medical Oncology
state: Alberta
city: Vancouver
country: Canada
facility: British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre
state: British Columbia
city: Moncton
country: Canada
facility: The Moncton Hospital
state: New Brunswick
city: Oshawa
country: Canada
facility: Lakeridge Health Oshawa; Oncology
state: Ontario
city: Toronto
country: Canada
facility: St. Michael'S Hospital
state: Ontario
city: Windsor
country: Canada
facility: Windsor Regional Cancer Centre
state: Ontario
city: Greenfield Park
country: Canada
facility: CSSS champlain - Charles-Le Moyne
state: Quebec
city: Montreal
country: Canada
facility: Mcgill University - Royal Victoria Hospital; Oncology
state: Quebec
city: Antofagasta
country: Chile
facility: Centro Oncológico Antofagasta
city: Santiago
country: Chile
facility: Instituto Nacional del Cancer
city: Temuco
country: Chile
facility: Sociedad de Investigaciones Medicas Ltda (SIM)
city: Valparaiso
country: Chile
facility: Hospital Carlos Van Buren, Servicio de Oncologia
city: Bogota
country: Colombia
facility: Clinica del Country
city: Cali
country: Colombia
facility: Clínica Imbanaco; Oncology
city: Osijek
country: Croatia
facility: Clinical Hospital Osijek; Dept For Oncology & Radiotherapy
city: Zagreb
country: Croatia
facility: Clinical Hospital Centre Zagreb
city: Brno
country: Czechia
facility: Masarykův onkologický ústav; Klinika komplexní onkologické péče
city: Olomouc
country: Czechia
facility: Fakultní nemocnice Olomouc
city: Praha 5
country: Czechia
facility: Fakultní Nemocnice V Motole; Radioterapeuticko-Onkologicke Oddeleni
city: Santiago
country: Dominican Republic
facility: Hospital Metropolitano de Santiago
city: Cuenca
country: Ecuador
facility: Instituto de Cáncer SOLCA Cuenca; Oncología
city: Guayaquil
country: Ecuador
facility: Solca Guayaquil- Sociedad de Lucha Contra El Cáncer; Oncology
city: Quito
country: Ecuador
facility: Hospital Solca Quito; Oncologia
city: Alexandria
country: Egypt
facility: Alexandria Uni ; Medical Oncology
city: Cairo
country: Egypt
facility: Manial Specialized Hospital; Oncology
city: Cairo
country: Egypt
facility: Nci; Oncology Dept
city: Salvador
country: El Salvador
facility: Hospital Oncologia; Oncology
city: Besancon
country: France
facility: HOPITAL JEAN MINJOZ; Oncologie
city: Bordeaux
country: France
facility: Clinique Tivoli; Sce Radiotherapie
city: Bordeaux
country: France
facility: Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie
city: Bourg En Bresse
country: France
facility: Ch De Fleyriat; Pneumologie 1
city: Brest
country: France
facility: Hopital Augustin Morvan; Federation De Cancerologie
city: Brive La Gaillarde
country: France
facility: Ch De Brive La Gaillarde; Radiotherapie Oncologie
city: Chalon Sur Saone
country: France
facility: Clinique Sainte Marie; Chimiotherapie
city: Dijon
country: France
facility: Fondation Clement Drevon; Oncology
city: Dijon
country: France
facility: Centre Georges-François Lecler; Ctr de Lutte Contre le Canc
city: Draguignan
country: France
facility: Ch De La Dracenie; Hopital De Jour
city: Guilherand Granges
country: France
facility: Hopital Prive Drome Ardeche; Chir 2A 2B
city: Hyeres
country: France
facility: Clinique Sainte Marguerite; Oncologie Medicale
city: La Roche Sur Yon
country: France
facility: CHD Les Oudairies
city: La Tronche
country: France
facility: Hopital Albert Michallon; Oncologie
city: Le Mans
country: France
facility: Ch Du Mans; Medecine Hematologie Oncologie
city: LeMans
country: France
facility: Clinique Victor Hugo
city: Levallois Perret
country: France
facility: Centre Hartmann
city: Lille
country: France
facility: Polyclinique Du Bois; Centre Bourgogne
city: Lille
country: France
facility: Hopital Claude Huriez; Medecine Interne Oncologie
city: Lorient
country: France
facility: Ch Bretagne Sud Site Scorff; Oncologie Medicale
city: Lorient
country: France
facility: CH Bretagne Sud Site Bodelio; Oncologie Radiotherapie
city: Lyon
country: France
facility: Ctre Consultations La Sauvegarde
city: Marseille
country: France
facility: Hôpital Saint Joseph; Oncologie Medicale
city: Metz Tessy
country: France
facility: CHRA;Hematologie
city: Metz
country: France
facility: Hopital Clinique Claude Bernard; Oncologie Medicale
city: Montpellier
country: France
facility: Clinique Clementville; Hopital De Jour
city: Mougins
country: France
facility: Centre Azureen De Cancerologie; Cons externes
city: Nice
country: France
facility: Centre Antoine Lacassagne; B3 Medecine Conventionnelle
city: Paris
country: France
facility: Hopital Cochin; Unite Fonctionnelle D Oncologie
city: Paris
country: France
facility: Hopital Hotel Dieu; Oncologie Medicale
city: Paris
country: France
facility: HOPITAL TENON; Cancerologie Medicale
city: Pau
country: France
facility: Ch Francois Mitterrand; Medecine Oncologie
city: Pierre Benite
country: France
facility: Ch Lyon Sud; Onco Secteur Jules Courmont
city: Saint Gregoire
country: France
facility: Chp Saint Gregoire; Cancerologie Radiotherapie
city: Saint Herblain
country: France
facility: Ico Rene Gauducheau; Oncologie
city: Saint Jean
country: France
facility: Clinique de L'Union; Oncologie
city: Saint Quentin
country: France
facility: Ch De Saint Quentin; Medecine B10
city: Saint-priest-en-jarez
country: France
facility: Institut de Cancerologie de La Loire; Pneumologie
city: St Martin Boulogne
country: France
facility: CMCO De La Cote D Opale; Auberge De Jour
city: Strasbourg
country: France
facility: Centre Paul Strauss; Oncologie Medicale
city: Thonon Les Bains
country: France
facility: Hopitaux Du Leman Site Thonon; Maternite Gynecologie
city: Toulouse
country: France
facility: Institut Claudius Regaud; Departement Oncologie Medicale
city: Toulouse
country: France
facility: Clinique Pasteur; Pneumologie
city: Valenciennes
country: France
facility: Clinique Radio Des Dentellieres; Chimiotherapie Radiotherapie
city: Vandoeuvre-les-Nancy
country: France
facility: Centre-Alexis Vautrin
city: Augsburg
country: Germany
facility: Klinikum Augsburg; Frauenklinik
city: Bad Soden
country: Germany
facility: Internist; Praxis Für Haemotologie & Onkologie
city: Berlin
country: Germany
facility: Praxis Dres. Schilling & Till
city: Berlin
country: Germany
facility: Vivantes Klinikum Am Urban; Zentrum für Brusterkrankungen
city: Bielefeld
country: Germany
facility: Katholische Hospitalvereinigung Ostwestfalen gGmbH
city: Bochum
country: Germany
facility: Gemeinschaftspraxis Dr. Bueckner und Dr. Nueckel
city: Deggendorf
country: Germany
facility: DONAU ISAR Klinikum Deggendorf; Frauenklinik
city: Essen
country: Germany
facility: Universitätsklinikum Essen; Zentrum Für Frauenheilkunde
city: Essen
country: Germany
facility: Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum
city: Freiburg
country: Germany
facility: Universitätsklinikum Freiburg; Frauenklinik
city: Georgsmarienhütte
country: Germany
facility: Klinikum St. Georg GmbH; Franziskus-Hospital Harderberg; Klinik für Gynaekologie und Geburtshilfe
city: Halle
country: Germany
facility: Krankenhaus St. Elisabeth und St. Barbara, Klinik für Frauenheilkunde und Geburtshilfe
city: Hamburg
country: Germany
facility: Universitätsklinikum Hamburg-Eppendorf; Zentrum für operative Medizin Klinik für Gynäkologie
city: Hamburg
country: Germany
facility: Kooperatives Mammazentrum Hamburg Krankenhaus Jerusalem
city: Hannover
country: Germany
facility: Gynaekologisch-Onkologische Schwerpunktpraxis Prof. Dr. med. Lueck, Dr. Schrader und Dr. Noeding
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover, Klinik für Frauenheilkunde und Geburtshilfe
city: Heidelberg
country: Germany
facility: Nationales Centrum für Tumorerkrankungen (NCT) ; Gyn. Onk. Frauenklinik; Uniklinikum Heidelberg
city: Jena
country: Germany
facility: Universitätsklinikum Jena; Klinik und Poliklinik für Frauenheilkunde und Fortpflanzungsmedizin
city: Kassel
country: Germany
facility: Elisabeth-Krankenhaus Brustzentrum
city: Koeln
country: Germany
facility: St. Elisabeth Krankenhaus Köln GmbH; Gynäkologie und Geburtshilfe
city: Kulmbach
country: Germany
facility: Klinikum Kulmbach; Frauenklinik
city: Köln
country: Germany
facility: Praxis Dr.med. Katja Ziegler-Löhr
city: Köln
country: Germany
facility: Kliniken der Stadt Köln gGmbH Krankenhaus Holweide; Brustzentrum
city: Langen
country: Germany
facility: Dres. Andreas Köhler und Roswitha Fuchs
city: Leverkusen
country: Germany
facility: Klinikum Leverkusen; Med. Klinik III / Onkologie
city: Ludwigsburg
country: Germany
facility: Klinikum Ludwigsburg; Klinik für Frauenheilkunde und Geburtshilfe
city: Lübeck
country: Germany
facility: Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Klinik für Frauenheilkunde und Geburtshilfe
city: Lübeck
country: Germany
facility: Onkologische Schwerpunktpraxis Lübeck
city: Mainz
country: Germany
facility: Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde
city: Marburg
country: Germany
facility: Gemeinschaftspraxis Fr. Dr. med. Balser & Hr. Dr. med. Weidenbach
city: Meiningen
country: Germany
facility: Klinikum Meiningen Klinik f.Gynäkologie und Geburtshilfe
city: Memmingen
country: Germany
facility: Klinikum Memmingen; Abt.Gynäkologie
city: Minden
country: Germany
facility: Mühlenkreiskliniken; Johannes Wesling Klinikum Minden; Klinik für Frauenheilkunde und Geburtshilfe
city: Mühlhausen
country: Germany
facility: Praxis Dr.med. Steffi Busch
city: München
country: Germany
facility: Gemeinschaftspraxis Prof. Dr.med. Christoph Salat und Dr.med. Oliver J. Stötzer
city: München
country: Germany
facility: Praxis Dr. Prechtl & Dr. Kowolik; Frauenklinik
city: Münster
country: Germany
facility: Universitätsklinikum Münster; Klinik für Frauenheilkunde und Geburtshilfe
city: Neuruppin
country: Germany
facility: Ruppiner Kliniken, Klinik fuer Gynaekologie und Geburtshilfe
city: Nürnberg
country: Germany
facility: Klinikum Nord Frauenklinik
city: Offenbach
country: Germany
facility: Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe
city: Ostfildern
country: Germany
facility: medius KLINIK OSTFILDERN-RUIT; Brustzentrum
city: Recklinghausen
country: Germany
facility: Oncologianova GmbH
city: Rotenburg/Wümme
country: Germany
facility: Agaplesion Diakonieklinikum Rotenburg
city: Saarbruecken
country: Germany
facility: Caritas Klinik St. Theresia -Frauenklinik Brustzentrum
city: Schweinfurt
country: Germany
facility: Leopoldina Krankenhaus der Stadt Schweinfurt GmbH
city: Schwerin
country: Germany
facility: HELIOS Klinikum Schwerin; Frauenklinik
city: Stendal
country: Germany
facility: Johanniter-Krankenhaus Genthin-Stendal; Klinik Für Frauenheilkunde & Geburtshilfe
city: Torgau
country: Germany
facility: Kreiskrankenhaus Torgau; Abt.Gynäkologie und Geburtshilfe
city: Tübingen
country: Germany
facility: Universitätsklinik Tübingen; Frauenklinik
city: Unna
country: Germany
facility: Katharinen-Hospital gGmbH
city: Weinheim
country: Germany
facility: GRN-Klinik Weinheim; Abt.Gynäkologie und Geburtshilfe
city: Weißenfels
country: Germany
facility: ASKLEPIOS KREISKRANKENHÄUSER WEIßENFELS-HOHENMÖLSEN GMBH
city: Wetzlar
country: Germany
facility: Lahn-Dill Kliniken GmbH Klinikum Wetzlar Gynäkologie/Geburtshilfe
city: Wuerselen
country: Germany
facility: Gesellschaft für Medizinische Studien Würselen
city: Athens
country: Greece
facility: Anticancer Hospital Ag Savas; 1St Dept of Internal Medicine
city: Athens
country: Greece
facility: Laiko General Hospital; 1St Pathological Clinic
city: Athens
country: Greece
facility: Alexandras General Hospital of Athens; Oncology Department
city: Heraklion
country: Greece
facility: Periph. University General Hospital of Heraklion Crete; Oncology Department
city: Kifisia
country: Greece
facility: Agioi Anargyroi Cancer Hospital; 2Nd Oncology Dept.
city: Thessaloniki
country: Greece
facility: Euromedical General Clinic of Thessaloniki; Oncology Department
city: Thessaloniki
country: Greece
facility: Papageorgiou General Hospital; Medical Oncology
city: Αλεξανδρουπολη
country: Greece
facility: Uni Hospital of Alexandroupoli; Dept. of Oncology - Duth
city: Λαρισα
country: Greece
facility: University Hospital of Larissa; Oncology
city: Guatemala City
country: Guatemala
facility: Grupo Angeles
city: Guatemala
country: Guatemala
facility: Centro Oncológico Sixtino / Centro Oncológico SA
city: Hong Kong
country: Hong Kong
facility: Queen Elizabeth Hospital; Clinical Oncology
city: Shatin
country: Hong Kong
facility: Prince of Wales Hosp; Dept. Of Clinical Onc
city: Budapest
country: Hungary
facility: Szent Margit Hospital; Dept. of Oncology
city: Budapest
country: Hungary
facility: Szent Imre Hospital; Dept. of Oncology
city: Budapest
country: Hungary
facility: Orszagos Onkologiai Intezet
city: Budapest
country: Hungary
facility: Semmelweis Egyetem Aok; Iii.Sz. Belgyogyaszati Klinika
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont ; Department of Oncology
city: Nyíregyháza
country: Hungary
facility: Josa Andras Korhaz; Dept of Oncoradiology
city: Pécs
country: Hungary
facility: Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet
city: Szombathely
country: Hungary
facility: Markusovszky Hospital
city: Bandung
country: Indonesia
facility: Hasan Sadikin Hospital; Internal Medicine
city: Central Jakarta
country: Indonesia
facility: CiptoMangunkusumo Hospital; Internal Medicine
city: East Java
country: Indonesia
facility: Soetomo Hospital; Surgery
city: Jakarta
country: Indonesia
facility: Dharmais National Cancer Center
city: Jogjakarta
country: Indonesia
facility: Sardjito Hospital; Instalasi Kanker Tulip
city: Dublin
country: Ireland
facility: Mater Misericordiae Uni Hospital; Oncology
city: Dublin
country: Ireland
facility: Mater Private Hospital
city: Dublin
country: Ireland
facility: Beaumont Hospital; Cancer Clinical Trials Unit
city: Limerick City
country: Ireland
facility: University Hospital Limerick
city: Sligo
country: Ireland
facility: Sligo General Hospital; Oncology
city: Waterford
country: Ireland
facility: Waterford Regional Hospital; Department Of Medical Oncology
city: Rionero in Vulture
country: Italy
facility: Ospedale Oncologico Regionale; U.O. Oncologia Medica Ed Ematologia
state: Basilicata
city: Napoli
country: Italy
facility: Azienda Ospedaliera A. Cardarelli
state: Campania
city: Napoli
country: Italy
facility: Istituto Nazionale Tumori Irccs Fondazione g. PASCALE;U.O.C. Oncologia Medica Senologica
state: Campania
city: Napoli
country: Italy
facility: Università degli Studi Federico II; Clinica di Oncologia Medica
state: Campania
city: Meldola
country: Italy
facility: IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
state: Emilia-Romagna
city: Parma
country: Italy
facility: Ospedale Regionale Di Parma; Divisione Di Oncologia Medica
state: Emilia-Romagna
city: Piacenza
country: Italy
facility: Az. Osp. Ospedale Civile; U.O. Di Oncologia Medica Ed Ematologia
state: Emilia-Romagna
city: Ravenna
country: Italy
facility: Azienda USL di Ravenna; Unità Operativa di Oncologia Medica
state: Emilia-Romagna
city: Frosinone
country: Italy
facility: Ausl Frosinone - Ospedale Umberto I; Divisione Di Oncologia
state: Lazio
city: Roma
country: Italy
facility: IFO - Istituto Regina Elena; Oncologia Medica
state: Lazio
city: Roma
country: Italy
facility: Policlinico Umberto i di Roma; dip. Scienze Radiologiche, Oncologiche, Anatomopatologiche
state: Lazio
city: Roma
country: Italy
facility: Azienda Ospedaliera Sant'Andrea
state: Lazio
city: Viterbo
country: Italy
facility: Ospedale Belcolle Di Viterbo; Oncologia
state: Lazio
city: Bergamo
country: Italy
facility: Asst Papa Giovanni XXIII; Oncologia Medica
state: Lombardia
city: Cremona
country: Italy
facility: ASST DI CREMONA; Unità di Patologia Mammaria Senologia e Breast Unit
state: Lombardia
city: Milano
country: Italy
facility: Fondazione IRCCS Istituto Nazionale dei Tumori; S. C. Oncologia Medica 2
state: Lombardia
city: Monza
country: Italy
facility: ASST DI MONZA; Oncologia Medica
state: Lombardia
city: Pavia
country: Italy
facility: IRRCCS San Matteo; Dip Oncoematologico ; Divisione Oncologia
state: Lombardia
city: Rozzano
country: Italy
facility: IRCCS Istituto Clinico Humanitas; Oncologia
state: Lombardia
city: Torino
country: Italy
facility: A.O. Città della Salute e della Scienza - Presidio Molinette; divisione oncologia medica
state: Piemonte
city: Bari
country: Italy
facility: Irccs Ist. Tumori Giovanni Paolo Ii; Dipartimento Oncologia Medica
state: Puglia
city: Lecce
country: Italy
facility: Ospedale Vito Fazzi; Div. Oncoematologia
state: Puglia
city: San Giovanni Rotondo
country: Italy
facility: IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia
state: Puglia
city: Cagliari
country: Italy
facility: Ospedale Oncologico A.Businco; Div. Oncologia Medica II
state: Sardegna
city: Sassari
country: Italy
facility: Ospedale Civile SS Annunziata; oncologia medica
state: Sardegna
city: Catania
country: Italy
facility: Ospedale Garibaldi Nesima; Biomedicina Clinica e Molecolare
state: Sicilia
city: Firenze
country: Italy
facility: Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1
state: Toscana
city: Pisa
country: Italy
facility: Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2
state: Toscana
city: Pontedera
country: Italy
facility: Azienda usl 5 Di Pisa-Ospedale Di Pontedera;U.O. Oncologia
state: Toscana
city: Camposampiero
country: Italy
facility: Ospedale Civile; Oncologia Medica
state: Veneto
city: Cona (Ferrara)
country: Italy
facility: Arcispedale S.Anna; Oncologia Medica
state: Veneto
city: Goyang-si
country: Korea, Republic of
facility: National Cancer Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Seoul
country: Korea, Republic of
facility: Yonsei University Severance Hospital; Medical Oncology
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center.
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health. Sciences Kaunas Clinics
city: Klaipeda
country: Lithuania
facility: Klaipeda University Hospital
city: Georgetown
country: Malaysia
facility: Hospital Pulau Pinang; Jabatan Radioterapi & Onkologi
city: Kuala Lumpur
country: Malaysia
facility: University Malaya Medical Centre; Clinical Oncology Unit,
city: Sabah
country: Malaysia
facility: Hospital Wanita dan Kanak-Kanak Sabah
city: Sarawak
country: Malaysia
facility: Sarawak General Hospital; Department of Radiotherapy, Oncology and Palliative care
city: Campeche
country: Mexico
facility: Centro Estatal de Oncología de Campeche
city: Chihuahua
country: Mexico
facility: Centro Estatal de Cancerología
city: Distrito Federal
country: Mexico
facility: Instituto Nacional de Cancerologia; Oncology
city: Mexico City
country: Mexico
facility: Consultorio de Medicina Especializada; Dentro de Condominio San Francisco
city: Oaxaca
country: Mexico
facility: Oaxaca Site Management Organization
city: Queretaro, Queretaro
country: Mexico
facility: Cancerologia de Queretaro; Oncologia
city: Tepic
country: Mexico
facility: Centro Estatal de Cancerologia de Nayarit
city: Rabat
country: Morocco
facility: Institut National D'oncologie Sidi Med Benabdellah
city: 'S Hertogenbosch
country: Netherlands
facility: Jeroen Bosch Ziekenhuis
city: AC Amsterdam
country: Netherlands
facility: Onze Lieve Vrouwe Gasthuis
city: Apeldoorn
country: Netherlands
facility: Gelre Ziekenhuis Apeldoorn, Lokatie Lukas; Afdeling Interne Geneeskunde
city: Arnhem
country: Netherlands
facility: Rijnstate Ziekenhuis; Inwendige Geneeskunde
city: Dordrecht
country: Netherlands
facility: Albert Schweitzer Ziekenhuis - loc Dordrecht
city: EDE
country: Netherlands
facility: Ziekenhuis Gelderse Vallei; Inwendige Geneeskunde
city: Eindhoven
country: Netherlands
facility: Catharina Ziekenhuis; Dept of Internal Medicin
city: Eindhoven
country: Netherlands
facility: Maxima Medisch Centrum; Inwendige Geneeskunde
city: Groningen
country: Netherlands
facility: Martini Ziekenhuis; Dept of Internal Medicine
city: Heerlen
country: Netherlands
facility: Atrium Medisch Centrum Parkstad, Heerlen
city: Hoofddorp
country: Netherlands
facility: Spaarne Ziekenhuis; Inwendige Geneeskunde
city: Nieuwegein
country: Netherlands
facility: St. Antonius Ziekenhuis Nieuwegein
city: Roosendaal
country: Netherlands
facility: Franciscus Ziekenhuis
city: Rotterdam
country: Netherlands
facility: Maasstad ziekenhuis; Afdeling oncologie hematologie
city: Rotterdam
country: Netherlands
facility: Ikazia Ziekenhuis
city: Schiedam
country: Netherlands
facility: Vlietland Ziekenhuis, Locatie Schiedam; Interne Geneeskunde
city: Sittard-Geleen
country: Netherlands
facility: Zuyderland ziekenhuis locatie Geleen
city: Utrecht
country: Netherlands
facility: Diakonessenhuis Utrecht: ziekenhuisapotheek
city: Venlo
country: Netherlands
facility: Ziekenhuis VieCurie Vitaal
city: Zaandam
country: Netherlands
facility: Zaans Medisch Centrum
city: Tauranga
country: New Zealand
facility: Tauranga Hospital, Clinical Trials Unit; BOP Clinical School
city: Kristiansand
country: Norway
facility: Sørlandet Sykehus Kristiansand
city: Oslo
country: Norway
facility: Oslo universitetssykehus HF, Ullevål, Kreftsenteret
city: Stavanger
country: Norway
facility: Helse Stavanger HF, Stavanger Universitetssjukehus; Klinikk for Blod og kreftsykdommer
city: Islamabad
country: Pakistan
facility: Shifa International Hospital; Department of Oncology
city: Karachi
country: Pakistan
facility: Aga Khan University; Department of Oncology
city: Lahore
country: Pakistan
facility: Shaukat Khanum Memorial Cancer Hospital; Department of Oncology
city: Lahore
country: Pakistan
facility: Hameed Latif Hospital; Department of Oncology
city: Panama
country: Panama
facility: Centro Hemato Oncologico Panama
city: Arequipa
country: Peru
facility: Centro Medico Monte Carmelo
city: Lima
country: Peru
facility: Instituto Nacional de Enfermedades Neoplasicas
city: Lima
country: Peru
facility: Clinica de Especialidades Medicas
city: Lima
country: Peru
facility: Clinica Internacional, Sede San Borja; Unidad de Investigacion de Clínica Internacional
city: LIma
country: Peru
facility: Instituto Oncologico de Lima
city: Manila
country: Philippines
facility: Philippine General Hospital; Section Of Medical Oncology
city: Quezon City
country: Philippines
facility: East Avenue Medical Center
city: Kraków
country: Poland
facility: Poradnia Onkologiczna oraz Oddzial Kliniczny Onkologii SPZOZ Szpital Uniwersytecki
city: Otwock
country: Poland
facility: Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii
city: Poznan
country: Poland
facility: Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu
city: Poznan
country: Poland
facility: Wielkopolskie Centrum Onkologi
city: Rzeszow
country: Poland
facility: MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie
city: Torun
country: Poland
facility: Wojewodzki Szpital Zespolony
city: Zory
country: Poland
facility: NZOZ Onko-Dent SP. P. G. L. Slomian, Poradnia Onkologiczna
city: Lisboa
country: Portugal
facility: Centro Clinico Champalimaud; Oncologia Medica
city: Lisboa
country: Portugal
facility: Hospital da Luz; Departamento de Oncologia Medica
city: Porto
country: Portugal
facility: IPO do Porto; Servico de Oncologia Medica
city: Porto
country: Portugal
facility: Hospital de Sao Joao; Servico de Oncologia
city: Baia Mare
country: Romania
facility: Policlinica Sfanta Maria - Oncology; Medical Oncology
city: Bucharest
country: Romania
facility: Emergency University Bucharest Hospital; Oncology Department
city: Bucuresti
country: Romania
facility: Institut of Oncology Al. Trestioreanu Bucharest; Oncology Department
city: Cluj Napoca
country: Romania
facility: Prof. Dr. I. Chiricuta Institute of Oncology
city: Cluj-Napoca
country: Romania
facility: Cluj Clinical County Hospital; Oncology Dept
city: Craiova
country: Romania
facility: SC Oncolab SRL
city: Craiova
country: Romania
facility: Clinical Hospital 1 Craiova; Medical Oncology
city: Timisoara
country: Romania
facility: S.C. Life Search S.R.L; Medical Oncology Clinic
city: Timisoara
country: Romania
facility: ONCOMED - Medical Centre
city: Irkutsk
country: Russian Federation
facility: Regional Oncology Hospital
city: Izhevsk
country: Russian Federation
facility: City Oncological Hospital
city: Moscow
country: Russian Federation
facility: Russian Oncology Research Center n.a. N.N. Blokhin Dpt of Clinical Pharmacology and Chemotherapy
city: Moscow
country: Russian Federation
facility: City Clinical Oncology Hospital
city: Orenburg
country: Russian Federation
facility: State Inst. Of Healthcare Orenburg Regional Clinical Oncology Dis
city: Saint-Petersburg
country: Russian Federation
facility: City Clinical Oncology Dispensary, SPb SBIH CCOD
city: UFA
country: Russian Federation
facility: Bashkirian Republican Clinical Oncology Dispensary
city: Jeddah
country: Saudi Arabia
facility: King Faisal Specialist Hospital & Research Centre
city: Riyadh
country: Saudi Arabia
facility: King Abdul Aziz Medical City, King Fahd National Guard; Oncology
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Bezanijska kosa; Clinic for Oncology
city: Belgrade
country: Serbia
facility: Institute for Onc/Rad Serbia
city: Kragujevac
country: Serbia
facility: Clinical Center Kragujevac
city: Nis
country: Serbia
facility: Clinical Centre Nis, Clinic for Oncology
city: Sremska Kamenica
country: Serbia
facility: Oncology Institute of Vojvodina
city: Singapore
country: Singapore
facility: National Cancer Centre; Medical Oncology
city: Banská Bystrica
country: Slovakia
facility: Mammacentrum sv. Agáty
city: Bratislava
country: Slovakia
facility: National Cancer Institute - Comenius University; Dept. Clinical Oncology
city: Košice
country: Slovakia
facility: Vychodoslovensky onkologicky ustav
city: Presov
country: Slovakia
facility: Fakultna nemocnica s poliklinikou J.A. Reimana Presov
city: Trencin
country: Slovakia
facility: Fakultna nemocnica Trencín; Onkologicke odd.
city: Maribor
country: Slovenia
facility: University Medical Centre Maribor; Depart. of Gynecology & Breast Oncology
city: Durban
country: South Africa
facility: Westridge Medical Center
city: Johannesburg
country: South Africa
facility: Donald Gordon Medical Centre
city: Pretoria
country: South Africa
facility: Steve Biko Academic Hospital; Oncology
city: Elda
country: Spain
facility: Hospital General de Elda; Servicio de Oncologia
state: Alicante
city: Gijon
country: Spain
facility: Hospital de Cabueñes; Servicio de Oncologia
state: Asturias
city: Badalona
country: Spain
facility: Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
state: Barcelona
city: Sabadell
country: Spain
facility: Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
state: Barcelona
city: Santander
country: Spain
facility: Hospital Universitario Marques de Valdecilla; Servicio de Oncologia
state: Cantabria
city: San Sebastian
country: Spain
facility: IInstituto Oncologico de San Sebastian, Oncologikoa; Servicio de Oncologia
state: Guipuzcoa
city: Palma De Mallorca
country: Spain
facility: Hospital Universitario Son Espases
state: Islas Baleares
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Universitario Materno Infantil de Gran Canaria; Servicio de Oncologia
state: LAS Palmas
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital de Gran Canaria Dr. Negrin; Servicio de Oncologia
state: LAS Palmas
city: Pozuelo de Alarcon
country: Spain
facility: Hospital Quiron de Madrid; Servicio de Oncologia
state: Madrid
city: Vigo
country: Spain
facility: Hospital Do Meixoeiro; Servicio de Oncologia
state: Pontevedra
city: La Laguna
country: Spain
facility: Hospital Universitario de Canarias;servicio de Oncologia
state: Tenerife
city: Santa Cruz de Tenerife
country: Spain
facility: Complejo Hospitalario Nuestra Señora de la Candelaria; Servicio de Oncologia
state: Tenerife
city: Xativa
country: Spain
facility: Hospital Lluis Alcanys; Servicio de Oncologia
state: Valencia
city: Bilbao
country: Spain
facility: Hospital de Basurto; Servicio de Oncologia
state: Vizcaya
city: Albacete
country: Spain
facility: Complejo Hospitalario Universitario de Albacete; Servicio de Oncologia
city: Alicante
country: Spain
facility: Hospital General Univ. de Alicante; Servicio de Oncologia
city: Barcelona
country: Spain
facility: Hospital del Mar; Servicio de Oncologia
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia
city: Barcelona
country: Spain
facility: Hospital Duran i Reynals; Oncologia
city: Burgos
country: Spain
facility: Complejo Asistencial Universitario De Burgos; Servicio de Oncologia
city: Caceres
country: Spain
facility: Hospital San Pedro De Alcantara; Servicio de Oncologia
city: Jaen
country: Spain
facility: Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
city: Leon
country: Spain
facility: Complejo Asistencial Universitario de Leon; Servicio de Oncologia
city: Lerida
country: Spain
facility: Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia
city: Madrid
country: Spain
facility: Hospital Ramon y Cajal; Servicio de Oncologia
city: Madrid
country: Spain
facility: Hospital Universitario Clínico San Carlos; Servicio de Oncologia
city: Madrid
country: Spain
facility: HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia
city: Murcia
country: Spain
facility: Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia
city: Navarra
country: Spain
facility: Hospital de Navarra; Servicio de Oncologia
city: Toledo
country: Spain
facility: Complejo Hospitalario de Toledo- H. Virgen de la Salud; Servicio de Oncologia
city: Valencia
country: Spain
facility: Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia
city: Lund
country: Sweden
facility: Skånes University Hospital, Skånes Department of Onclology
city: Skoevde
country: Sweden
facility: Skaraborgs sjukhus Skoevde, Dept of surgery
city: Aarau
country: Switzerland
facility: Hirslanden Medical Center, Tumorzentrum
city: Baden
country: Switzerland
facility: Kantonsspital Baden; Frauenklinik
city: Bellinzona
country: Switzerland
facility: Ospedale San Giovanni; Oncologia
city: Bern
country: Switzerland
facility: Inselspital Bern; Universitätsklinik für medizinische Onkologie
city: Frauenfeld
country: Switzerland
facility: Kantonsspital Frauenfeld, Frauenklinik Thurgau
city: Lausanne
country: Switzerland
facility: CHUV; Departement d'Oncologie
city: Thun
country: Switzerland
facility: Spital Thun; Medizinische Klinik
city: Winterthur
country: Switzerland
facility: Kantonsspital Winterthur; Medizinische Onkologie
city: Zürich
country: Switzerland
facility: Stadtspital Triemli; Frauenklinik
city: Taichung
country: Taiwan
facility: China Medical University Hospital; Surgery
city: Tainan
country: Taiwan
facility: National Cheng Kung Uni Hospital; Surgery
city: Taipei
country: Taiwan
facility: National Taiwan Uni Hospital; General Surgery
city: Taipei
country: Taiwan
facility: Tri-Service General Hospital, Division of General Surgery
city: Bangkok
country: Thailand
facility: Department of Surgery, King Chulalongkorn Memorial Hospital
city: Bangkok
country: Thailand
facility: Pramongkutklao Hospital; Medicine - Medical Oncology Unit
city: Bangkok
country: Thailand
facility: Rajvithi Hospital
city: Bangkok
country: Thailand
facility: Ramathibodi Hospital; Medicine/Oncology
city: Chiang Mai
country: Thailand
facility: Maharaj Nakorn Chiang Mai Hospital; Department of Surgery/Head Neck and Breast Unit; Clinical Trial
city: Dusit
country: Thailand
facility: Oncology Unit, Faculty of Medicine, Vajira Hospital; Department of Medicine
city: Ankara
country: Turkey
facility: Ankara Uni School of Medicine; Medical Oncology
city: Antalya
country: Turkey
facility: Akdeniz University Medical Faculty; Medical Oncology Department
city: Diyarbakir
country: Turkey
facility: Dicle University Faculty of Medicine
city: Gaziantep
country: Turkey
facility: Gaziantep Univ. Med. Fac.
city: Istanbul
country: Turkey
facility: Istanbul Uni of Medicine Faculty; Oncology Dept
city: Istanbul
country: Turkey
facility: Marmara Uni Faculty of Medicine; Medical Oncology
city: Izmit
country: Turkey
facility: Kocaeli University Faculty of Medicine; Medical oncology
city: Mersin
country: Turkey
facility: Mersin University Medical Faculty
city: Samsun
country: Turkey
facility: 19 Mayis University Medical Faculty; Medical Oncology Department
city: Sihhiye/Ankara
country: Turkey
facility: Hacettepe Uni Medical Faculty Hospital; Oncology Dept
city: Kiev
country: Ukraine
facility: Kyiv City Clinical Oncological Center; Chemotherapy Department
city: Lviv
country: Ukraine
facility: State Oncology Regional Treatment-Diagnostic Center; Chemotherapy Department
city: Al Ain
country: United Arab Emirates
facility: Tawam Hospital
city: Abergavenny
country: United Kingdom
facility: Nevill Hall Hospital
city: Bedford
country: United Kingdom
facility: Bedford Hospital; Oncology
city: Berkshire
country: United Kingdom
facility: Wexham Park Hospital; Oncology
city: Birmingham
country: United Kingdom
facility: University Hospital Birmingham Queen Elizabeth Hospital
city: Birmingham
country: United Kingdom
facility: Heartlands Hospital; Department Of Medicine
city: Bournemouth
country: United Kingdom
facility: Royal Bournemouth Hospital; Oncology
city: Canterbury
country: United Kingdom
facility: Kent & Canterbury Hospital
city: Chelmsford
country: United Kingdom
facility: Broomfield Hospital; Oncology
city: Denbighshire
country: United Kingdom
facility: Glan Clwyd Distr Gen Hospital;Nth Wales Cancer Treatment Ctr
city: Derby
country: United Kingdom
facility: Royal Derby Hospital
city: Devon
country: United Kingdom
facility: North Devon District Hospital
city: Dudley
country: United Kingdom
facility: Russells Hall Hospital; Oncology
city: Durham
country: United Kingdom
facility: University Hospital of North Durham
city: Glasgow
country: United Kingdom
facility: Beatson West of Scotland Cancer Centre
city: Greenock
country: United Kingdom
facility: Inverclyde Hospital
city: Grimsby
country: United Kingdom
facility: Diana Princess of Wales Hosp.
city: Guildford
country: United Kingdom
facility: Royal Surrey County Hospital
city: Harlow
country: United Kingdom
facility: Princess Alexandra Hospital; Oncology Department
city: Huddersfield
country: United Kingdom
facility: Huddersfield Royal Infirmary
city: Ipswich
country: United Kingdom
facility: Ipswich Hospital
city: Kilmarnock
country: United Kingdom
facility: Crosshouse Hospital; Dept of Oncology
city: Larbert
country: United Kingdom
facility: Forth Valley Royal Hospital ; Oncology Department
city: Leicester
country: United Kingdom
facility: Leicester Royal Infirmary
city: Livingston
country: United Kingdom
facility: St John's Hospital
city: London
country: United Kingdom
facility: Guys and St Thomas NHS Foundation Trust, Guys Hospital
city: London
country: United Kingdom
facility: Queen Elizabeth Hospital
city: London
country: United Kingdom
facility: St George's Hospital
city: Macclesfield
country: United Kingdom
facility: Macclesfield District General Hospital
city: Manchester
country: United Kingdom
facility: Christie Hospital; Breast Cancer Research Office
city: New Castle Upon Tyne
country: United Kingdom
facility: Freeman Hospital; Northern Centre For Cancer Care
city: Newport
country: United Kingdom
facility: Royal Gwent Hospital
city: North Shields
country: United Kingdom
facility: North Tyneside General Hospital
city: Northampton
country: United Kingdom
facility: Northampton General Hospital NHS Trust
city: Plymouth
country: United Kingdom
facility: Derriford Hospital; Plymouth Oncology Centre
city: Poole
country: United Kingdom
facility: Poole General Hospital
city: Portsmouth
country: United Kingdom
facility: Queen Alexandra Hospital, Portsmouth
city: Preston
country: United Kingdom
facility: Royal Preston Hospital
city: Romford
country: United Kingdom
facility: Queens Hospital; R&D
city: Scarborough
country: United Kingdom
facility: Scarborough General Hospital
city: Shrewsbury
country: United Kingdom
facility: Royal Shrewsbury Hospital; Pharmacy Department
city: Southampton
country: United Kingdom
facility: Southampton General Hospital
city: Sunderland
country: United Kingdom
facility: Sunderland Royal Hospital
city: Swansea
country: United Kingdom
facility: Singleton Hospital; Pharmacy Department
city: Swindon
country: United Kingdom
facility: Great Western Hospital, Swindon Cancer Research Unit; Osprey Unit Level 3
city: Truro
country: United Kingdom
facility: Royal Cornwall Hospital
city: Winchester
country: United Kingdom
facility: Royal Hampshire County Hospital; Winchester & Andover Breast Unit
city: Wirral
country: United Kingdom
facility: The Clatterbridge Cancer Ctr For Oncolgy
city: Wolverhampton
country: United Kingdom
facility: The Royal Wolverhampton Hospitals NHS Trust
city: York
country: United Kingdom
facility: Airedale General Hospital; Oncology
city: York
country: United Kingdom
facility: York District Hospital
city: Montevideo
country: Uruguay
facility: Grupo Oncológico Cooperativo Uruguayo; Hospital de Clínicas - Dpto. de Oncología
city: Montevideo
country: Uruguay
facility: Hospital Militar; Oncologia
city: Montevideo
country: Uruguay
facility: Hospital Pereira Rossell; Oncology Department
city: Caracas
country: Venezuela
facility: Instituto Oncológico Luis Razetti
city: Caracas
country: Venezuela
facility: Centro Integral de Oncología
city: Caracas
country: Venezuela
facility: Centro Médico Docente La Trinidad; Unidad de Protocolos Clínicos
city: Hanoi
country: Vietnam
facility: K hospital
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References:
citation: Jung KH, Ataseven B, Verrill M, Pivot X, De Laurentiis M, Al-Sakaff N, Lauer S, Shing M, Gligorov J, Azim HA. Adjuvant Subcutaneous Trastuzumab for HER2-Positive Early Breast Cancer: Subgroup Analyses of Safety and Active Medical Conditions by Body Weight in the SafeHer Phase III Study. Oncologist. 2018 Oct;23(10):1137-1143. doi: 10.1634/theoncologist.2018-0065. Epub 2018 Jul 17.
citation: Gligorov J, Ataseven B, Verrill M, De Laurentiis M, Jung KH, Azim HA, Al-Sakaff N, Lauer S, Shing M, Pivot X; SafeHer Study Group. Safety and tolerability of subcutaneous trastuzumab for the adjuvant treatment of human epidermal growth factor receptor 2-positive early breast cancer: SafeHer phase III study's primary analysis of 2573 patients. Eur J Cancer. 2017 Sep;82:237-246. doi: 10.1016/j.ejca.2017.05.010. Epub 2017 Jun 16.