Clinical trial NCT05416723: Occupational and Environmental Origins of ANCA Vasculitis: Contribution of Data From the National Network for Vigilance and Prevention of Occupational Pathologies (RNV3P)
Official title: Occupational and Environmental Origins of ANCA Vasculitis: Contribution of Data From the National Network for Vigilance and Prevention of Occupational Pathologies (RNV3P)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: ANCA Associated Vasculitis
Occupational Diseases
Environmental Exposure
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2022-06-13
Enrollment: 302
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with ANCA vasculitis seen in French occupational disease consultation centres.

Brief summary: The main objective is to identify specific risk factors for ANCA vasculitis of occupational and/or environmental origin (exposures identified by questioning, geographical distribution of cases) from the RNV3P data.

The secondary objectives are as follows:

* Description of cases of ANCA vasculitis seen in French occupational pathology consultation centres:

  * reasons for consultation,
  * occupational and environmental etiologies described
  * occupational situations responsible
  * aptitude notices
  * recognition as an occupational disease
* Identification of specific risk factors for ANCA vasculitis of occupational and/or environmental origin (exposures identified on questioning, geographical distribution of cases).
* For occupational and non-occupational cases of ANCA vasculitis: identification of difficulties encountered by patients at work and proposed work adaptations.
* Estimation of the number of applications for recognition of disabled worker status made within this patient group.
* Identification of clinical severity and autoimmune profiles of ANCA vasculitis of occupational and/or environmental origin.


Eligibility criteria: Inclusion Criteria:

* Patient with ANCA vasculitis defined according to the International Classification of Diseases (ICD-10), i.e. M 308, M 31, N 057 and L 95, or mentioned as the reason for consultation in the text mining summary.
* Seen in consultation in the occupational disease consultation centres belonging to the RNV3P
* No opposition

Exclusion Criteria:

* Refusal to participate

Primary outcomes:
measure: Number of diagnoses of ANCA vasculitis in the RNV3P
timeFrame: 4 months
Secondary outcomes:
measure: Imputability of the coded diagnoses of ANCA vasculitis.
timeFrame: 4 months
measure: Number of patients with ANCA vasculitis for whom occupational and/or environmental exposure to microcrystalline silica was identified.
timeFrame: 4 months
measure: Number of patients with ANCA vasculitis for whom other occupational and/or environmental exposure was identified.
timeFrame: 4 months
measure: Number of patients with ANCA vasculitis for whom an application for recognition as a disabled worker has been submitted.
timeFrame: 4 months
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: CHU de Bordeaux
city: Grenoble
country: France
facility: CHU de Grenoble
city: Lille
country: France
facility: CHU de LILLE
city: Lyon
country: France
facility: HCL
city: Marseille
country: France
facility: AP-HM
city: Nancy
country: France
facility: CHU de Nancy
city: Nantes
country: France
facility: CHU de Nantes
city: Paris
country: France
facility: Hôpital Cochin ( AP-HP)
city: Rennes
country: France
facility: CHU de Rennes
city: Strasbourg
country: France
facility: CHU de Strasbourg
city: Toulouse
country: France
facility: CHU de Toulouse
Study officials:
References: