Clinical trial NCT04136002: Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode
Official title: Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Lead sponsor: Guardant Health, Inc.
Sponsor class: INDUSTRY
Collaborators: name: Premier Research Group plc
First posted: 2019-10-23
Enrollment: 44467
Sex: ALL
Minimum age (years): 45
Maximum age (years): 84
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Single cohort of patients aged between 45 and 84, with no known high risk features, undergoing routine colorectal cancer screening as standard of care.

Brief summary: The ECLIPSE (Evaluation of the ctDNA LUNAR test in an Average Patient Screening Episode) study is a prospective, observational multi-site study without randomization. The primary objective of the study is to evaluate the performance characteristics of a blood-based ctDNA LUNAR-2 test to detect colorectal cancer in a screen-relevant, average risk population.

Detailed description: The LUNAR-2 test has been developed to detect malignant disease in screen-relevant patients who would otherwise undergo screening for malignant disease using invasive methodologies such as colonoscopy. The intended use of such a test would be to return a result of ctDNA detected/ ctDNA not detected in a patient eligible for average risk screening for colorectal cancer. Those patients who receive a ctDNA detected result should undergo further investigation with colonoscopy.

In order to define the performance characteristics of the test in a relevant population, this study will perform a blood draw prior to the patient undergoing the standard of care colonoscopy (and all associated preparatory medications) and retrospectively compare the performance characteristics of the LUNAR-2 test with the findings of the index colonoscopy.

Outcomes of patients at one and two-years post-procedure will be collected as secondary endpoints to investigate the possibility of incidental, non-colorectal cancer cases and interval cancers that had not reached the clinical threshold for detection at the time of the index colonoscopy.

Eligibility criteria: Inclusion Criteria:

1. Subjects aged 45-84 years at time of consent
2. Intended to undergo screening colonoscopy
3. Considered by a physician or healthcare provider as being of 'average risk' for CRC
4. Willing to consent to blood draw pre-bowel preparation administration prior to undergoing colonoscopy within 60 days of the date of the investigational blood draw
5. Willing to consent to follow-up for two years as per protocol

Exclusion Criteria:

1. Undergoing colonoscopy for investigation of symptoms
2. Has undergone colonoscopy within preceding 9 years
3. Positive FIT/FOBT result within the previous 6 months
4. Has completed Cologuard or Epi proColon testing within the previous 3 years
5. History of colorectal cancer
6. History of any malignancy (patients who have undergone surgical removal of skin squamous cell cancer may be enrolled provided the procedure was completed at least 12 months prior to the date of provision of informed consent for the study)
7. Known diagnosis of inflammatory bowel disease
8. Currently taking any anti-neoplastic or disease-modifying anti-rheumatic drugs (DMARDs)
9. Positive family history of colorectal cancer, defined as having one or more first- degree relatives (parent, sibling, or child) with CRC at any age
10. Known hereditary/germline risk of colorectal cancer (for example, Lynch syndrome or Hereditary Non-Polyposis CRC \[HNPCC\], or Familial Adenomatous Polyposis \[FAP\])
11. Any major physical trauma (e.g. disruption of tissue, surgery, organ transplant, blood product transfusion) within the 30 days leading up to the provision of informed consent
12. Known medical condition which, in the opinion of the investigator, should preclude enrollment into the study
13. Participation in a clinical research study in which an experimental medication has been administered or may be administered within the 30 days leading up to providing informed consent or may be administered through the time of colonoscopy

Primary outcomes:
measure: Sensitivity of colorectal cancer detection
timeFrame: 60 days
measure: Specificity of advanced neoplasia detection
timeFrame: 60 days
Secondary outcomes:
measure: Positive predictive value of colorectal cancer detection
timeFrame: 60 days
measure: Negative predictive value of colorectal cancer detection
timeFrame: 60 days
measure: Sensitivity and specificity of advanced adenoma detection
timeFrame: 60 days
Other outcomes:
Locations:
city: Anniston
country: United States
facility: Pinnacle Research Group, LLC
state: Alabama
city: Guntersville
country: United States
facility: Lakeview Clinical Research
state: Alabama
city: Huntsville
country: United States
facility: Medical Affiliated Research Center
state: Alabama
city: Jasper
country: United States
facility: Jasper Summit Research LLC
state: Alabama
city: Chandler
country: United States
facility: Hope Research Institute
state: Arizona
city: Chandler
country: United States
facility: Southeast Valley Gastroenterology
state: Arizona
city: Gilbert
country: United States
facility: Prime Medical Group, LLC
state: Arizona
city: Glendale
country: United States
facility: Hope Research Institute
state: Arizona
city: Phoenix
country: United States
facility: GI Research Associates, LLC
state: Arizona
city: Phoenix
country: United States
facility: "Forty-Third Medical Associates Absolute Clinical Research"
state: Arizona
city: Tucson
country: United States
facility: Del Sol Research Management, LLC
state: Arizona
city: Tucson
country: United States
facility: Novak Clinical Research
state: Arizona
city: Little Rock
country: United States
facility: Preferred Research Partners, Inc
state: Arkansas
city: Little Rock
country: United States
facility: Premier Gastroenterology
state: Arkansas
city: North Little Rock
country: United States
facility: Arkansas Gastroenterology
state: Arkansas
city: Anaheim
country: United States
facility: Associated Gastroenterology Medical Group
state: California
city: Arcadia
country: United States
facility: InSite Digestive Health Care
state: California
city: Burlingame
country: United States
facility: Gastroenterology
state: California
city: Camarillo
country: United States
facility: Ventura County Gastroenterology Medical Group
state: California
city: Canoga Park
country: United States
facility: Hope Clinical Research
state: California
city: Canoga Park
country: United States
facility: Alliance Research Institute
state: California
city: Chula Vista
country: United States
facility: Gastro SB Clinic
state: California
city: Chula Vista
country: United States
facility: Precision Research Institute
state: California
city: Encinitas
country: United States
facility: BG Clinical Research and affiliate of The Clinical Trials Network, LLC
state: California
city: Encinitas
country: United States
facility: Diagnamics, Inc
state: California
city: Fullerton
country: United States
facility: Helping Hands Healthcare Group
state: California
city: Garden Grove
country: United States
facility: Paragon RX Clinical, Inc.
state: California
city: Huntington Beach
country: United States
facility: Digestive Health Research of Southern California
state: California
city: Irvine
country: United States
facility: United Medical Doctors
state: California
city: Lancaster
country: United States
facility: Gastro Care Institute
state: California
city: Los Angeles
country: United States
facility: LA Gastroenterology Group
state: California
city: Los Angeles
country: United States
facility: University of Southern California
state: California
city: Los Angeles
country: United States
facility: Gastroenterology Associates of Beverly Hills
state: California
city: Orange
country: United States
facility: Knowledge Research Center
state: California
city: Oxnard
country: United States
facility: InSite Digestive Health Care-San Gabriel
state: California
city: Palm Springs
country: United States
facility: Desert Oasis Healthcare Medical Group
state: California
city: Palm Springs
country: United States
facility: Palm Tree Clinical, Inc
state: California
city: Pasadena
country: United States
facility: InSite Digestive Health Care - Gastroenterology Associates
state: California
city: Sacramento
country: United States
facility: Northern California Research
state: California
city: San Diego
country: United States
facility: San Diego Gastroenterology Medical Associates
state: California
city: San Diego
country: United States
facility: SDG Clinical Research, Inc.
state: California
city: San Diego
country: United States
facility: Precision Research Institute
state: California
city: San Diego
country: United States
facility: Medical Associates Research Group
state: California
city: Thousand Oaks
country: United States
facility: FOMAT Simoni AGI Medical
state: California
city: Toluca Lake
country: United States
facility: Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc
state: California
city: Walnut Creek
country: United States
facility: Curebase
state: California
city: Walnut Creek
country: United States
facility: Clinical Research of California
state: California
city: Bridgeport
country: United States
facility: Gastroenterology Associates of Fairfield County
state: Connecticut
city: Hamden
country: United States
facility: CMR of Greater New Haven, LLC
state: Connecticut
city: New Haven
country: United States
facility: Yale University
state: Connecticut
city: Aventura
country: United States
facility: Innovative Medical Research of South Florida, Inc.
state: Florida
city: Boynton Beach
country: United States
facility: Reciomed Clinical Research Network, Inc.
state: Florida
city: Coral Gables
country: United States
facility: Clinical Research of South Florida, an AMR Company
state: Florida
city: Doral
country: United States
facility: Dolphin Medical Research
state: Florida
city: Gainesville
country: United States
facility: University of Florida College of Medicine
state: Florida
city: Hialeah
country: United States
facility: Palmetto Research, LLC
state: Florida
city: Hollywood
country: United States
facility: The Center for Gastrointestinal Disorders
state: Florida
city: Hollywood
country: United States
facility: Research Centers of America
state: Florida
city: Jupiter
country: United States
facility: Health Awareness, Inc
state: Florida
city: Jupiter
country: United States
facility: Jupiter Medical Center
state: Florida
city: Lake City
country: United States
facility: Multi-Specialty Research Associates
state: Florida
city: Lake Mary
country: United States
facility: University Clinical Research-DeLand, LLC dba Accel Research Sites
state: Florida
city: Lakewood Ranch
country: United States
facility: Florida Research Institute
state: Florida
city: Melbourne
country: United States
facility: University Clinical Research-DeLand, LLC dba Accel Research Sites
state: Florida
city: Miami Lakes
country: United States
facility: Crystal Biomedical Research
state: Florida
city: Ocala
country: United States
facility: Ocala GI Research, LLC
state: Florida
city: Ocala
country: United States
facility: Sarkis Clinical Trials
state: Florida
city: Orange City
country: United States
facility: Gastroenterology of Greater Orlando
state: Florida
city: Orlando
country: United States
facility: Gastroenterology Institute of Orlando
state: Florida
city: Palm Harbor
country: United States
facility: Advanced Gastroenterology Associates, LLC
state: Florida
city: Sunrise
country: United States
facility: Precision Clinical Research, LLC
state: Florida
city: Tampa
country: United States
facility: Guardian Angel Research Center, LLC
state: Florida
city: Atlanta
country: United States
facility: Digestive Health Care of Georgia
state: Georgia
city: Atlanta
country: United States
facility: Emory University School of Medicine
state: Georgia
city: Atlanta
country: United States
facility: Metro Atlanta Gastroenterology, LLC.
state: Georgia
city: Columbus
country: United States
facility: Columbus Regional Research Institute
state: Georgia
city: Evans
country: United States
facility: Gastroenterology Consultants of Augusta
state: Georgia
city: Lawrenceville
country: United States
facility: SKY Clinical Research Network Group
state: Georgia
city: Riverdale
country: United States
facility: Infinite Clinical Trials
state: Georgia
city: Sandy Springs
country: United States
facility: WR-Mount Vernon Clinical Research, LLC
state: Georgia
city: Union City
country: United States
facility: Rolphe Adult and Pediatric Medicine
state: Georgia
city: Champaign
country: United States
facility: Christie Clinic
state: Illinois
city: Chicago
country: United States
facility: University of Chicago Medicine
state: Illinois
city: Chicago
country: United States
facility: Curebase
state: Illinois
city: Downers Grove
country: United States
facility: Digestive Health Services
state: Illinois
city: Hines
country: United States
facility: Edward Hines Jr. VA Hospital
state: Illinois
city: Lake Barrington
country: United States
facility: Gastroenterology & Internal Medicine Specialist, SC, Avicenna Clinical Research
state: Illinois
city: Naperville
country: United States
facility: Suburban Gastroenterology Ltd
state: Illinois
city: Northbrook
country: United States
facility: Comprehensive Gastrointestinal Health
state: Illinois
city: Oak Lawn
country: United States
facility: DM Clinical Research
state: Illinois
city: Rockford
country: United States
facility: Rockford Gastroenterology Associates, Ltd.
state: Illinois
city: South Bend
country: United States
facility: Digestive Research Alliance of Michiana
state: Indiana
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics
state: Iowa
city: El Dorado
country: United States
facility: Alliance for Multispecialty Research, LLC
state: Kansas
city: Shawnee Mission
country: United States
facility: West Glen Gastrointestinal Consultants, P.A.
state: Kansas
city: Wichita
country: United States
facility: Alliance for Multispecialty Research-Wichita West
state: Kansas
city: Wichita
country: United States
facility: Kansas Gastroenterology, LLC
state: Kansas
city: Crestview Hills
country: United States
facility: Tri-State Gastroenterology Associates
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville Research Foundation
state: Kentucky
city: Louisville
country: United States
facility: Robley Rex VA Medical Center
state: Kentucky
city: Covington
country: United States
facility: Northlake Gastroenterology Associates
state: Louisiana
city: Hammond
country: United States
facility: Northlake Gastroenterology Associates
state: Louisiana
city: Houma
country: United States
facility: CroNola LLC
state: Louisiana
city: Lafayette
country: United States
facility: Gastroclinic
state: Louisiana
city: Lake Charles
country: United States
facility: Clinical Trials of SWLA, LLC
state: Louisiana
city: Monroe
country: United States
facility: Delta Research Partners
state: Louisiana
city: Shreveport
country: United States
facility: Louisiana Research Center, LLC
state: Louisiana
city: Columbia
country: United States
facility: Gastro Center of Maryland
state: Maryland
city: Elkridge
country: United States
facility: Centennial Medical Group
state: Maryland
city: Frederick
country: United States
facility: Frederick Gastroenterology Associates
state: Maryland
city: Greenbelt
country: United States
facility: Mid-Atlantic GI Research
state: Maryland
city: Rockville
country: United States
facility: Meridian Clinical Research
state: Maryland
city: Chelmsford
country: United States
facility: Digestive Health Specialists
state: Massachusetts
city: South Weymouth
country: United States
facility: South Suburban Gastroenterology
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
city: Rochester Hills
country: United States
facility: Onyx Clinical Research
state: Michigan
city: Saginaw
country: United States
facility: Covenant HealthCare
state: Michigan
city: Southfield
country: United States
facility: Revive Research Institute, LLC
state: Michigan
city: Troy
country: United States
facility: Clinical Research Institute of Michigan, LLC
state: Michigan
city: Eagan
country: United States
facility: Curebase
state: Minnesota
city: Columbus
country: United States
facility: Gastroenterology Associates of Mississippi
state: Mississippi
city: Jackson
country: United States
facility: Southern Therapy and Advanced Research
state: Mississippi
city: Ridgeland
country: United States
facility: Quinn Healthcare
state: Mississippi
city: Chesterfield
country: United States
facility: Clinical Research Professionals, LLC
state: Missouri
city: Saint Joseph
country: United States
facility: Digestive Health Specialists, LLC
state: Missouri
city: Saint Louis
country: United States
facility: Saint Louis University GI & Hepatology Research Unit
state: Missouri
city: Saint Louis
country: United States
facility: Washington University School of Medicine Gastroenterology
state: Missouri
city: Saint Louis
country: United States
facility: Sundance Clinical Research
state: Missouri
city: Elkhorn
country: United States
facility: Skyline Medical Center, PC/CCT Research
state: Nebraska
city: Omaha
country: United States
facility: Midwest Regional Health Services, LLC/CCT Research
state: Nebraska
city: Las Vegas
country: United States
facility: Excel Clinical Research
state: Nevada
city: Las Vegas
country: United States
facility: Wr-Crcn, Llc
state: Nevada
city: Reno
country: United States
facility: Gastroenterology Consultants
state: Nevada
city: Reno
country: United States
facility: Advanced Research Institute
state: Nevada
city: Reno
country: United States
facility: Gastroenterology Consultants
state: Nevada
city: Berlin
country: United States
facility: Hassman Research Institute
state: New Jersey
city: Brick
country: United States
facility: Allied Health Clinical Research Organization, LLC
state: New Jersey
city: Clifton
country: United States
facility: Gastroenterology Associates Of New Jersey
state: New Jersey
city: Florham Park
country: United States
facility: AIG Digestive Disease Research
state: New Jersey
city: Freehold
country: United States
facility: Allied Health Clinical Research Organization, LLC
state: New Jersey
city: Hackensack
country: United States
facility: Hackensack Digestive Disease Associates
state: New Jersey
city: Hillsborough
country: United States
facility: Digestive Healthcare Center
state: New Jersey
city: Jackson
country: United States
facility: Allied Health Clinical Research Organization
state: New Jersey
city: Montclair
country: United States
facility: Gastroenterology Associates Of New Jersey
state: New Jersey
city: Ocean City
country: United States
facility: Dr. Howard N. Guss and Dr. Gagan Beri
state: New Jersey
city: Ridgewood
country: United States
facility: Gastroenterology Associates Of New Jersey
state: New Jersey
city: Teaneck
country: United States
facility: Teaneck Gastroenterology Associates
state: New Jersey
city: Union
country: United States
facility: Advanced Gastroenterology Group
state: New Jersey
city: Wayne
country: United States
facility: Gastroenterology Associates Of New Jersey
state: New Jersey
city: Wayne
country: United States
facility: North Jersey Gastroenterology
state: New Jersey
city: Woodland Park
country: United States
facility: Gastroenterology Associates Of New Jersey
state: New Jersey
city: Albuquerque
country: United States
facility: Lovelace Scientific Resources, Inc.
state: New Mexico
city: Brooklyn
country: United States
facility: Sam Moskowitz, MD
state: New York
city: Brooklyn
country: United States
facility: NY Scientific
state: New York
city: Camillus
country: United States
facility: Associated Gastroenterologists of Central New York, Camillus
state: New York
city: East Syracuse
country: United States
facility: Associated Gastroenterology of Central New York
state: New York
city: Fayetteville
country: United States
facility: Associated Gastroenterologists of Central New York
state: New York
city: Fresh Meadows
country: United States
facility: Intercity Gastroenterology
state: New York
city: Lawrence
country: United States
facility: South Island Gastro
state: New York
city: Manorville
country: United States
facility: East End Gastroenterology & Hepatology
state: New York
city: New City
country: United States
facility: Gastrointestinal Associates of Rockland
state: New York
city: Richmond Hill
country: United States
facility: Smart Medical Research
state: New York
city: Syracuse
country: United States
facility: Syracuse Gastro Associates
state: New York
city: Utica
country: United States
facility: Digestive Disease Medicine Of Central New York
state: New York
city: Valley Stream
country: United States
facility: GastroCare LI
state: New York
city: Wantagh
country: United States
facility: Gastrointestinal Specs Lng Is
state: New York
city: West Nyack
country: United States
facility: Eric L. Tatar, MD
state: New York
city: Asheville
country: United States
facility: Digestive Health Partners
state: North Carolina
city: Cary
country: United States
facility: Cary Gastro Associates
state: North Carolina
city: Chapel Hill
country: United States
facility: UNC Division of Gastroenterology and Hepatology
state: North Carolina
city: Charlotte
country: United States
facility: Charlotte Gastroenterology & Hepatology, PLLC
state: North Carolina
city: Charlotte
country: United States
facility: Carolina Digestive Health Associates, PA
state: North Carolina
city: Charlotte
country: United States
facility: Javara Research
state: North Carolina
city: Charlotte
country: United States
facility: Carolinas Research Center
state: North Carolina
city: Concord
country: United States
facility: Carolina Digestive Health Associates, PA
state: North Carolina
city: Concord
country: United States
facility: Northeast GI Research Division
state: North Carolina
city: Fayetteville
country: United States
facility: Coastal Research Institute, LLC
state: North Carolina
city: Greensboro
country: United States
facility: Medication Management LLC
state: North Carolina
city: Pinehurst
country: United States
facility: Pinehurst Medical Clinic
state: North Carolina
city: Raleigh
country: United States
facility: Carolina's GI Research, LLC
state: North Carolina
city: Raleigh
country: United States
facility: PMG Research of Raleigh
state: North Carolina
city: Rocky Mount
country: United States
facility: Boice Willis Clinic, PA
state: North Carolina
city: Salisbury
country: United States
facility: PMG Research of Salisbury, LLC
state: North Carolina
city: Statesville
country: United States
facility: Piedmont HealthCare, PA
state: North Carolina
city: Wilmington
country: United States
facility: Wilmington Health
state: North Carolina
city: Wilmington
country: United States
facility: Trial Management Associates, LLC
state: North Carolina
city: Winston-Salem
country: United States
facility: PMG Research of Winston
state: North Carolina
city: Fargo
country: United States
facility: Lillestol Research, LLC
state: North Dakota
city: Fargo
country: United States
facility: Plains Clinical Research Center, LLC
state: North Dakota
city: Beachwood
country: United States
facility: Gastroenterology Associates of Cleveland
state: Ohio
city: Beavercreek
country: United States
facility: Dayton Gastroenterology, Inc.
state: Ohio
city: Beavercreek
country: United States
facility: Dayton Gastroenterology
state: Ohio
city: Cincinnati
country: United States
facility: Gastro Health Research
state: Ohio
city: Cincinnati
country: United States
facility: University of Cincinnati
state: Ohio
city: Columbus
country: United States
facility: ClinOhio Research Services
state: Ohio
city: Dayton
country: United States
facility: Advance Clinical Research
state: Ohio
city: Dayton
country: United States
facility: META Medical Research Institute
state: Ohio
city: Mentor
country: United States
facility: Great Lakes Gastroenterology
state: Ohio
city: Springboro
country: United States
facility: DSI Research, LLC
state: Ohio
city: Toledo
country: United States
facility: University of Toledo Internal Medicine Clinic
state: Ohio
city: Warren
country: United States
facility: Avamar Gastroenterology and Center
state: Ohio
city: Westlake
country: United States
facility: Northshore Gastroenterology & Endoscopy Center
state: Ohio
city: Oklahoma City
country: United States
facility: Digestive Disease Specialists, Inc
state: Oklahoma
city: Tulsa
country: United States
facility: Options Health Research, LLC
state: Oklahoma
city: Portland
country: United States
facility: Fanno Creek Group
state: Oregon
city: Portland
country: United States
facility: The Oregon Clinic - Gastroenterology East
state: Oregon
city: Allentown
country: United States
facility: Eastern Pennsylvania GI & Liver Specialists
state: Pennsylvania
city: Altoona
country: United States
facility: US Digestive Health at Blair
state: Pennsylvania
city: Beaver Falls
country: United States
facility: Valley Gastroenterology Associates
state: Pennsylvania
city: Camp Hill
country: United States
facility: Susquehanna Research Group, LLC
state: Pennsylvania
city: Harrisburg
country: United States
facility: Susquehanna Research Group
state: Pennsylvania
city: Philadelphia
country: United States
facility: Perelman Center for Advanced Medicine
state: Pennsylvania
city: Philadelphia
country: United States
facility: Einstein Medical Center Department of Digestive Disease and Transplantation
state: Pennsylvania
city: Uniontown
country: United States
facility: Frontier Clinical Research, LLC
state: Pennsylvania
city: Cranston
country: United States
facility: GIMED Associates, Inc.
state: Rhode Island
city: Narragansett
country: United States
facility: GIMED Associates, Inc.
state: Rhode Island
city: Greenwood
country: United States
facility: Digestive Disease Research Center
state: South Carolina
city: Mount Pleasant
country: United States
facility: Coastal Carolina Research Center
state: South Carolina
city: North Charleston
country: United States
facility: Southeast Medical Research/Elms Research
state: South Carolina
city: Orangeburg
country: United States
facility: South Carolina Clinical Research LLC
state: South Carolina
city: Summerville
country: United States
facility: PPCP Division of Gastroenterology LLC
state: South Carolina
city: West Columbia
country: United States
facility: Invocare Medical Research & Healthcare Center
state: South Carolina
city: Austin
country: United States
facility: Elligo Clinical Research Center
state: Tennessee
city: Chattanooga
country: United States
facility: Erlanger Health Clinical Resarch
state: Tennessee
city: Chattanooga
country: United States
facility: WR-ClinSearch, LLC
state: Tennessee
city: Germantown
country: United States
facility: Gastro One
state: Tennessee
city: Jackson
country: United States
facility: Helios Clinical Research lLC
state: Tennessee
city: Jackson
country: United States
facility: The Jackson Clinic, PA
state: Tennessee
city: Jackson
country: United States
facility: The Jackson Clinic
state: Tennessee
city: Johnson City
country: United States
facility: East Tennessee Research Institute
state: Tennessee
city: Kingsport
country: United States
facility: Tri-Cities Gastroenterology
state: Tennessee
city: Knoxville
country: United States
facility: Gastrointestinal Associates, P.C.
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
city: Union City
country: United States
facility: Advanced Gastroenterology
state: Tennessee
city: Cypress
country: United States
facility: Allied Digestive Disease Center
state: Texas
city: Cypress
country: United States
facility: Northside Gastroenterology Associates
state: Texas
city: Cypress
country: United States
facility: Uma Mohan MD PA
state: Texas
city: El Paso
country: United States
facility: El Paso Integrated Physicians Group, P.A.
state: Texas
city: Houston
country: United States
facility: Digestive Health Associates
state: Texas
city: Houston
country: United States
facility: University of Texas MD Anderson Cancer Center
state: Texas
city: Houston
country: United States
facility: Biopharma Informatic
state: Texas
city: Houston
country: United States
facility: Diversified Medical Practices
state: Texas
city: Houston
country: United States
facility: Houston Digestive Diseases Consultants
state: Texas
city: Houston
country: United States
facility: Memorial Hermann Surgery Center
state: Texas
city: Hurst
country: United States
facility: Protenium Clinical Research Inc.
state: Texas
city: McAllen
country: United States
facility: Biopharma Informatic
state: Texas
city: Pasadena
country: United States
facility: Gastroenterology Consultants, P.A.
state: Texas
city: San Antonio
country: United States
facility: Clinical Associates in Research Therapeutics of America
state: Texas
city: Shenandoah
country: United States
facility: Gastroenterology Partners of North Houston
state: Texas
city: Spring
country: United States
facility: Texas Gastroenterology Associates/A1 Clinical Network
state: Texas
city: Sugar Land
country: United States
facility: Gastroenterology Associates of Texas, PA
state: Texas
city: Tomball
country: United States
facility: Texas Gastro Consultants
state: Texas
city: Wichita Falls
country: United States
facility: Digestive Health Research of North Texas
state: Texas
city: Bountiful
country: United States
facility: Progressive Clinical Research
state: Utah
city: Ogden
country: United States
facility: Advanced Research Institute
state: Utah
city: Sandy
country: United States
facility: Advanced Research Institute Granite Peaks Gastroenterology
state: Utah
city: Charlottesville
country: United States
facility: Charlottesville Medical Research
state: Virginia
city: Chesapeake
country: United States
facility: Gastroenterology Associates of Tidewater
state: Virginia
city: Fairfax
country: United States
facility: Verity Research
state: Virginia
city: Lynchburg
country: United States
facility: Blue Ridge Medical Research
state: Virginia
city: Reston
country: United States
facility: The Gastroenterology Group
state: Virginia
city: Richmond
country: United States
facility: GI Select Health Research, LLC
state: Virginia
city: Williamsburg
country: United States
facility: Tidewater Physicians Multispecialty Group Clinical Research
state: Virginia
city: Bellevue
country: United States
facility: Washington Gastroenterology
state: Washington
city: Everett
country: United States
facility: Western Washington Medical Group, Inc
state: Washington
city: Spokane
country: United States
facility: Velocity Clinical Research
state: Washington
city: Manitowoc
country: United States
facility: Holy Family Memorial, Inc
state: Wisconsin
city: Milwaukee
country: United States
facility: Medical College of Wisconsin
state: Wisconsin
city: Stevens Point
country: United States
facility: GI Associates
state: Wisconsin
city: Wausau
country: United States
facility: GI Associates
state: Wisconsin
Study officials:
affiliation: Guardant Health, Inc.
name: Craig Eagle, MD
role: PRINCIPAL_INVESTIGATOR
References: