louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01418690: Changes in Tissue Oxygenation Following Regional Anesthesia
Official title: Changes in Tissue Oxygenation Following Regional Anesthesia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthesia, Local
Lead sponsor: Nationwide Children's Hospital
Sponsor class: OTHER
First posted: 2011-08-17
Enrollment: 29
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients requiring regional anesthetics.

Brief summary: Adequate tissue oxygenation is required for effective white blood cell function and bactericidal activity. Decreased tissue oxygenation is a risk factor for perioperative wound infections. Regional anesthetic techniques result in a functional sympathetic block and may increase tissue oxygenation. The purpose of this study is to evaluate changes in tissue oxygenation using a non-invasive Near-infrared spectroscopy (NIRS) device. The current study will evaluate changes in tissue oxygenation following regional anesthetic techniques (peripheral nerve blockade and neuraxial techniques such as caudal block) in pediatric patients).

Regional anesthesia will induce a sympathetic blockade and improve tissue oxygenation.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing a surgical procedure who have consented to a regional block.

Exclusion Criteria:

* None

Primary outcomes:
measure: Tissue oxygenation
timeFrame: 1 Day (Day of Surgery)
Secondary outcomes:
Other outcomes:
Locations:
city: Columbus
country: United States
facility: Nationwide Children's Hospital
state: Ohio
Study officials:
References:
Clinical trial NCT06190990: Otago Exercises and Otago Exercise Effects on Elderly Population
Official title: Additional Effects of Otago Exercises With Exer-gaming on Balance, Physical Performance and Gait Among the Elderly Population
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Elderly Population
Keywords: Exer gaming
Otago exercises
Distorted balance
Disturbed gait
Reduce physical performance
Older population
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2024-01-05
Enrollment: 44
Sex: ALL
Minimum age (years): 55
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Assignment
Primary purpose: TREATMENT

Brief summary: Study aims to investigate the profound impact of exer gaming on normal aged individuals within our society. Additionally, to compare the effects of exer gaming-based exercises and Otago exercises on crucial aspects such as balance, physical performance, and gait pattern among the normal aged population. This study holds immense significance as it has the potential to greatly improve the health and wellbeing of the elderly population. By identifying an efficacious physical therapy intervention to address the complications associated with balance, physical performance, and gait pattern, we can effectively mitigate further dysfunctions in this demographic.


Eligibility criteria: Inclusion Criteria:

* Both genders
* Age \> 55 Years
* Berg balance scale score 21-40
* Moca \>24
* Urinary bowel continence

Exclusion Criteria:

* Having history of other neurological conditions (i.e. Dementia, Parkinson's disease)
* Having contagious or inflammatory conditions.
* Having orthopedic limitations such as fractures
* Unable to comply with the training or currently participating in another interfering therapy
* With Vision problems
* Having uncontrolled cardiac conditions such as uncontrolled hypertension

Primary outcomes:
measure: Berg balance scale
timeFrame: 4th week
Secondary outcomes:
measure: Time Up and Go (TUG)
timeFrame: 4th week
measure: dynamic gait index
timeFrame: 4th week
measure: 10 Meter Walk Test (10MWT)
timeFrame: 4th week
measure: Montreal Cognitive Assessment
timeFrame: 4th week
Other outcomes:
Locations:
city: Peshawar
country: Pakistan
facility: RAFSAN Neuro Rehabilitation center
state: KPK
Study officials:
affiliation: Riphah International University
name: Sara Aabroo, MS NMPT
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02527590: Development of Stimulator Pneumatic for Realization of Evoked Potential Allodynic/Somatosensory
Official title: Development of Stimulator Pneumatic for Realization of Evoked Potential Allodynic/Somatosensory
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Neuropathic Pain
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2015-08-19
Enrollment: 71
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The stimuli used in the evoked potentials are electrical or laser. They are started and synchronized with the collection of the EEG by signals TTL (transistor-transistor logic). Investigators propose to validate a pneumatic stimulator delivering the compressed air sync with the EEG. It has two advantages over existing stimuli: Is capable of inducing in patients an allodynic response, excessive, painful, in response to a stimulation painless rarely obtained with laser or electrical stimuli. Therefore, the pneumatic stimulation is a means to study allodynic evoked potentials unknown to date.

It must be possible with a single stimulator to explore non-painful sensations and allodynic sensation , compare them with one device. The differences are the abnormal responses. This validation assumes evoked potential recording 1. somatosensory (low stimulation) then 2. allodynic (only in patients). The study therefore provides for the registration 100 potential for each of these two modalities in patients and only for the painless pneumatic modality in volunteers.


Eligibility criteria: Inclusion Criteria of patients :

* Major Patient
* Patient affiliated or entitled to a social security scheme
* Patient with neuropathic pain authenticated by the neurologist, with the presence of allodynia.
* Patient has given its written consent to participate in the study

Exclusion Criteria of patients :

* Diseases affecting the nervous system,
* Diabetes,
* Patients who received chemotherapy
* Pregnant woman
* Nobody in emergencies
* A person unable to give consent

Inclusion Criteria of healthy volunteers :

* Major subject
* Subject affiliated or entitled to a social security scheme
* Subject has given its consent to participate in the study

Exclusion Criteria of healthy volunteers :

* Diseases affecting the nervous system,
* Diabetes,
* Patients who received chemotherapy
* Pregnant woman
* Nobody in emergencies
* A person unable to give consent

Primary outcomes:
measure: composite outcomes : latencies and amplitudes of pneumatic evoked potential
timeFrame: Day 1
Secondary outcomes:
measure: latencies evoked potentials allodynic tires
timeFrame: Day 1
Other outcomes:
Locations:
city: Saint Etienne
country: France
facility: Chu de Saint Etienne
Study officials:
affiliation: Centre Hospitalier Universitaire de Saint Etienne
name: Roland PEYRON, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01267890: The Conflicts of Ethics and Law on Patient's Surrogate
Official title: Health Service Administration China Medical University (Chih-Jaan Tai)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Physician's Role
Keywords: ethics
law
surrogate
conflict
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2010-12-29
Enrollment: 120
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 120 physicians in two hospitals

Brief summary: This study is a prospective cross-sectional survey study. The investigators developed self-administrated questionnaire and recruit 120 physicians in two hospitals and 60 lawyers from some law firms to this study.

To realize and compare the opinions of physicians and lawyers about controversial decision-making of surrogate.

Detailed description: This study provides three real scenarios regarding dilemma between ethics and law when patient's surrogate may not represent patient's best interest：1. Parents ask physician resect their mentally handicapped daughter's uterus. 2. A son refuse physician's suggestion of surgical treatment for his mother, instead, wishes donating his mother's kidney to his son. 3. A mother decides to give up treatment for her son's head injury because of his rebel behavior before.

T-test, ANOVA and Logistic Regression will be used to analyze in this study.

Eligibility criteria: Inclusion Criteria:

* resident
* visiting Staff
* chief resident

Exclusion Criteria:

* intern
* clerk

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: China Medical University Hospital
Study officials:
References:
Clinical trial NCT00568490: Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
Official title: Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Head and Neck Cancer
Lung Cancer
Lip Cancer
Lip Neoplasms
Head and Neck Cancers
Lead sponsor: Stanford University
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2007-12-06
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Newly diagnosed patients with head and neck cancer

Brief summary: The purpose of this study is to identify and confirm new blood and tissue markers for prognosis and tumor hypoxia. Tumor hypoxia, or the condition of low oxygen in the tumor, has been shown to increase the risk of tumor spread and enhance tumor resistance to the standard treatment of radiation and chemotherapy in head and neck and lung cancers. We have recently identified several proteins or markers in the blood and in tumors (including osteopontin, lysyl oxidase, macrophage inhibiting factor and proteomic technology) in the laboratory that may be able to identify tumors with low oxygen levels or more aggressive behaving tumors.

Detailed description: The endpoints of the study are

1. To validate the prognostic significance of OPN in H\&N and lung cancer patients and to monitor its level during active therapy and follow up for cancer surveillance.
2. To identify a gene and protein signature for hypoxia in H\&N and lung cancer patients.

Eligibility criteria: Inclusion Criteria:

* Histologically confirmed squamous cell carcinoma of the head and neck sites or non-small cell lung cancer, or relatives of patients with histologically confirmed squamous cell carcinoma of the head and neck.
* Able to sign a Stanford IRB approved consent form

Exclusion criteria:

* Refuse or unable to sign an IRB approved consent form.
* Refuse to be contacted in the future for follow up.

Primary outcomes:
measure: Identification of Secreted Markers for Tumor Hypoxia through tissue collection
timeFrame: before therapy, weekly during therapy
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University School of Medicine
state: California
Study officials:
affiliation: Stanford University
name: Quynh-Thu Le
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02007590: Aerosure and Six Minute Walk Distance in Severe COPD
Official title: Does High-frequency Airflow Oscillation, Delivered Using Aerosure, Increase Exercise Capacity in Severe Chronic Obstructive Pulmonary Disease?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Lead sponsor: Actegy Ltd.
Sponsor class: INDUSTRY
First posted: 2013-12-11
Enrollment: 42
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: To investigate whether high frequency airflow oscillation (HFAO), delivered using Aerosure, increases six minute walk distance (6MWD) and reduces exertional breathlessness in patients with severe chronic obstructive pulmonary disease (COPD).


Eligibility criteria: Inclusion Criteria:

* Stable severe COPD (FEV1 \< 50% predicted)
* Modified MRC dyspnoea score 2 or greater
* At least 10 pack year smoking history
* Able to mobilise independently

Exclusion Criteria:

* Contraindications to spirometry \[1\]
* Contraindications to clinical exercise testing \[2\]
* Contraindications to HFAO (see section A.6.3b))
* Resting SpO2\>88% on air or on patient's usual oxygen prescription
* Systolic arterial blood pressure (ABP) \>200mmHg, diastolic ABP \>100 mmHg

  1. Cooper, B.G., An update on contraindications for lung function testing. Thorax, 2010.
  2. ATS/ACCP Statement on Cardiopulmonary Exercise Testing. Am. J. Respir. Crit. Care Med., 2003. 167(2): p. 211-277.

Primary outcomes:
measure: Six minute walk distance (6MWD)
timeFrame: up to 6 minutes
Secondary outcomes:
measure: end-6MWD Borg breathlessness
timeFrame: after 6 minute walk test
measure: Arterial oxygen saturation (SpO2)
timeFrame: At start of 6 minute walk test and after every 1 minute
Other outcomes:
measure: Inspiratory capacity (IC)
timeFrame: At end of 6 minute walk test
Locations:
city: London
country: United Kingdom
facility: King's College Hospital, Bessemer Road, Denmark Hill
Study officials:
affiliation: King's College Hospital NHS Trust
name: John Moxham, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01915290: Physical Activity and Its Correlation to Maximal Oxygen Uptake in an Elderly Population
Official title: Self Reported Physical Activity vs Objectively Measured Physical Activity and Its Correlation to Maximal Oxygen Uptake in an Elderly Population: an Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aging
Keywords: physical activity
maximal oxygen uptake
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
First posted: 2013-08-02
Enrollment: 1237
Sex: ALL
Minimum age (years): 70
Maximum age (years): 77
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Norwegian elderly population 70-77 years of age

Brief summary: This is a substudy of the Generation-100 study (NCT01666340). Self reported physical activity versus objectively measured physical activity and its correlation to maximal oxygen uptake in an elderly Norwegian population (observational study).

Detailed description: Data is collected using activity monitors. This data then compared to self reported physical activity obtained through questionnaires. Questionnaires are based on recall. Overall physical activity will then be correlated to maximal oxygen uptake to see whether people with high activity also have high maximal oxygen uptake.

Eligibility criteria: Inclusion Criteria:

* ability to walk at least 1km,
* born in 1938,1939,1940,1941 or 1942
* Sufficiently good health to be able to take part in the study, as determined by the researchers

Exclusion Criteria:

* Illness or disability that precludes exercise or hinders completion of the study
* Uncontrolled hypertension
* Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina
* Active cancer
* Test results indicating that study participation is unsafe
* Inclusion in other studies conflicting with participation in this one

Primary outcomes:
measure: Correlation between maximal oxygen uptake and activity level
timeFrame: baseline
Secondary outcomes:
measure: Difference between self reported recall physical activity and activity monitor measured physical activity
timeFrame: Baseline
Other outcomes:
measure: total daily energy expenditure
timeFrame: Baseline
measure: activity energy expenditure
timeFrame: baseline
measure: sedentary time
timeFrame: baseline
Locations:
Study officials:
affiliation: Norwegian University of Science and Technology
name: Dorthe Stensvold, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Norwegian University of Science and Technology
name: Ulrik Wisløff, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT05423990: Electroclinical Features of Sudden Unexpected Death in Epilepsy (SUDEP) : a Multi-center Observational Study
Official title: Electroclinical Features of Sudden Unexpected Death in Epilepsy (SUDEP) : a Multi-center Observational Study
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Sudden Unexpected Death in Epilepsy
Near-Sudden Unexpected Death in Epilepsy
Lead sponsor: Xijing Hospital
Sponsor class: OTHER
First posted: 2022-06-21
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with epilepsy who experience SUDEP or near-SUDEP identified in a multicenter study between April 2022 and April 2024.

Brief summary: Sudden unexpected death in epilepsy (SUDEP) is regarded as a leading cause of premature death in epilepsy patients. We aim to capture the whole process of SUDEP and near-SUDEP occurrence in patients with epilepsy, and expolre video-electroencephalograph (V-EEG) changes and marker. A Chinese multicenter study was carried out to determine electroencephalo-graph marker related to SUDEP to provide a scientific basis for the prevention of SUDEP in patients with epilepsy.


Eligibility criteria: Inclusion Criteria:

* Patients with epilepsy who meet SUDEP or near-SUDEP diagnosis,
* Giving written informed consent to participate in the study from relatives or caregivers.

Exclusion Criteria:

* Refusing to recruitment from relatives or caregivers.

Primary outcomes:
measure: The occurrence of SUDEP or near-SUDEP
timeFrame: 2022.04.01-2024.04.01
Secondary outcomes:
Other outcomes:
Locations:
city: Xi'an
country: China
facility: Liu Yonghong
state: Shaanxi
Study officials:
References:
Clinical trial NCT06501521: Non-invasive Brain Tumor Molecular Diagnostics and Monitoring
Official title: Non-invasive Brain Tumor Diagnosis Through Analysis of Proximal Fluids, Circulating Tumor Cells, and Biomolecules
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Brain Tumor
Lead sponsor: The Institute of Molecular and Translational Medicine, Czech Republic
Sponsor class: OTHER
First posted: 2024-07-15
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Inhabitants of Olomouc region

Brief summary: This prospective multicenter study aims to enroll GBM patients who will undergo repeated assessments (preoperatively and 3 months post-surgery) to detect circulating tumor cells and analyze the transcriptomic profiles of EVs in their blood. The prognostic and monitoring significance of these biomarkers to disease course (assessing treatment efficacy, resistance incidence, tumor progression) will be evaluated.

Concurrently, proteomic profiles typical of GBM will be analyzed in blood and ocular secretion samples from GBM patients, patients with low-grade gliomas, and patients without brain tumors to identify and validate novel protein biomarkers suitable for disease monitoring. Additionally, this study proposes an innovative approach to monitor GBM patients by investigating the presence of GBM-specific nucleic acid fragments in urine.


Eligibility criteria: Inclusion Criteria: Adult patients with brain tumors -

Exclusion Criteria: No other cancer; no inflammatory disease

-

Primary outcomes:
measure: Proteomic profiles of proximal liquids in brain tumor patients
timeFrame: 2020-2023
measure: Circulating tumor cells (CTCs) for non-invasive monitoring of GBM patients.
timeFrame: 2020-2030
measure: Extracellular vesicles (EVs) for non-invasive monitoring of GBM patients.
timeFrame: 2020-2030
measure: Urine as a source of GBM-specific nucleic acids fragments for disease monitoring.
timeFrame: 2025-2030
Secondary outcomes:
Other outcomes:
Locations:
city: Olomouc
country: Czechia
facility: Department of Neurosurgery, University Hospital Olomouc
Study officials:
affiliation: Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
name: Marian Hajduch, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06920121: Virtual Reality Glasses and Stress Ball on Distress and Pain Arteriovenous Fistula Cannulation
Official title: Effects of Virtual Reality Glasses and Stress Ball on Distress and Pain During Arteriovenous Fistula Cannulation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hemodialysis Complication
Lead sponsor: Istanbul Sabahattin Zaim University
Sponsor class: OTHER
First posted: 2025-04-09
Enrollment: 77
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Effects of Virtual Reality Glasses and Stress Ball on Distress and Pain During Arteriovenous Fistula Cannulation. The research was conducted as a randomized experimental study with a pre-test - post-test control group.

Detailed description: Beginning 1-2 minute before the start of the procedure, the patients will be watched (5 minutes) with an android mobile phone inserted into the Cardboard Super Flex Binoculars Glasses.

A stress ball will be applied to the patient 1-2 minutes before the start of the procedure.

Eligibility criteria: Inclusion Criteria:

* Be over 18 years old,
* Be able to speak and understand Turkish,
* Have the cognitive ability to answer the data collection tools,
* Be willing to participate in the study,
* Participate in a hemodialysis program three days a week,

Exclusion Criteria:

* Having a communication problem (hearing, language, understanding, etc.),
* Having a psychiatric diagnosis (To be checked from medical records),
* Having failed AVF cannulation at the first attempt,
* Having any signs of infection such as redness, swelling, open wound in the area where the procedure will be performed,
* Having used a sedative within the last 8 hours,
* Having used any painkillers before the procedure on the same day,

Primary outcomes:
measure: Visual Analog Scale
timeFrame: Baseline, pre-intervention (Before AVF cannulation procedure)
measure: Visual Analog Scale
timeFrame: Immediately after the intervention (After AVF cannulation procedure)
measure: The Distress Thermometer (DT
timeFrame: Baseline, pre-intervention (Before AVF cannulation procedure)
measure: The Distress Thermometer (DT
timeFrame: Immediately after the intervention (After AVF cannulation procedure)
Secondary outcomes:
Other outcomes:
Locations:
city: Küçükçekmece
country: Turkey
facility: Istanbul Sabahattin Zaim University, Faculty of Health Sciences
state: İstanbul
Study officials:
affiliation: İstanbul Sabahattin Zaim Üniversitesi
name: Zülfünaz Özer
role: PRINCIPAL_INVESTIGATOR
References:
citation: Toraman RL, Eskici Ilgin V. Effect of Virtual Reality Glasses Application on Pain, Anxiety, and Patient Satisfaction During a Transrectal Prostate Biopsy: A Randomized Controlled Trial. Biol Res Nurs. 2024 Oct;26(4):485-497. doi: 10.1177/10998004241236154. Epub 2024 Feb 28.