Clinical trial NCT02019264: A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
Official title: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Cardiovascular Disease
High Cardiovascular Risk
Obesity
Overweight
Type 2 Diabetes
Keywords: Diabetes
Cardiovascular Disease
Multiple Cardiovascular Risk Factors
Obesity
Overweight
MACE
Conversion to Diabetes
Lead sponsor: Eisai Inc.
Sponsor class: INDUSTRY
Collaborators: name: The TIMI Study Group
First posted: 2013-12-24
Enrollment: 14673
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study in overweight and obese subjects with cardiovascular (CV) disease and/or multiple CV risk factors.

Detailed description: Approximately 12,000 subjects will be randomized to two treatment groups in a ratio of 1:1, stratified by the presence of established CV disease (approximately 80%) or CV risk factors without established CV disease (approximately 20%). Subjects will receive lorcaserin HCl 10 mg BID or placebo BID. The study will consist of 2 phases: Prerandomization and Randomization. The Prerandomization Phase will last up to 30 days and consist of one visit during which subjects will be screened for eligibility. The Randomization Phase will consist of two periods: Treatment and Follow-up. The Treatment Period will last for approximately 5 years with approximately 18 visits and Follow-up period is 30 (+ or - 10 days) from the end of treatment visit.

Eligibility criteria: Inclusion Criteria

1. BMI greater than or equal (\>=) to 27 kilogram per meter square (kg/m\^2)
2. Subjects able and willing to comply with a reduced-calorie diet and an increased physical activity program
3. Age \>= to 40 years with established CV disease as defined by one of the following:

   1. History of documented MI or ischemic stroke
   2. History of peripheral artery disease
   3. History of revascularization (coronary, carotid, or peripheral artery)
   4. Significant unrevascularized coronary arterial stenosis

OR

Age \>= to 55 years for women or \>= to 50 years for men who have type 2 diabetes mellitus (T2DM) without established CV disease plus at least one of the following CV risk factors:

1. Hypertension, or currently receiving therapy for documented hypertension
2. Dyslipidemia, or currently taking prescription lipid-lowering therapy for documented dyslipidemia
3. Estimated glomerular filtration rate \>= to 30 to less than equal (\<=) to 60 mililitre per minute per 1.73 meter square (mL/min/1.73 m\^) per the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation
4. High high sensitivity C-reactive protein (hsCRP)
5. Urinary albumin-to-creatinine ratio (ACR) \>= 30 ug/mg

Subjects with T2DM may have a pre-existing or new diagnosis of T2DM. A new diagnosis of T2DM (ie, discovered at Screening) should be based on the 2013 American Diabetes Association (ADA) guidelines.

All T2DM subjects must have an HbA\[1c\] less (\<) than 10% at Screening. If subjects are being treated, or upon diagnosis need to be treated with antidiabetic agents, the T2DM treatment regimen must be stable for at least 3 months prior to randomization.

Exclusion Criteria

1. Moderate or greater symptoms of congestive cardiac failure (New York Heart Association \[NYHA\] class III or IV)
2. Known left ventricular (LV) ejection fraction \< than 20%
3. Moderate or greater symptoms of pulmonary hypertension (PH)
4. Known severe valvular disease
5. Moderate renal impairment, severe renal impairment (estimated glomerular filtration rate \< 30 mL/min/1.73 m\^ per the CKD-EPI equation based on ideal body weight), or end stage renal disease (ESRD)
6. Severe hepatic impairment
7. Use of other products intended for weight loss including prescription drugs, over-the-counter (OTC) drugs, and herbal preparations
8. Use of more than one other serotonergic drug
9. Use of drugs known to increase the risk for cardiac valvulopathy within 6 months prior to Screening including, but not limited to: pergolide, ergotamine, methysergide, cabergoline
10. History or evidence of clinically significant disease (e.g., malignancy, cardiac, respiratory, gastrointestinal, renal or psychiatric disease)
11. Use of lorcaserin HCl prior to Screening or hypersensitivity to lorcaserin HCl or any of the excipients
12. Planned bariatric surgery
13. Females must not be breastfeeding or pregnant

Primary outcomes:
measure: Time From Randomization to First Occurrence of Major Adverse Cardiovascular Events (MACE) at Interim Analysis
timeFrame: Baseline up to Month 42
measure: Time From Randomization to First Occurrence of MACE+
timeFrame: Baseline up to end of study (Month 56)
Secondary outcomes:
measure: Time From Randomization to Conversion to Type 2 Diabetes Mellitus (T2DM) for Participants With Prediabetes at Baseline
timeFrame: Baseline up to end of study (Month 56)
measure: Time From Randomization to First Occurrence of the Individual Components of MACE+
timeFrame: Baseline up to end of study (Month 56)
measure: Time From Randomization to Event of All-cause Mortality
timeFrame: Baseline up to end of study (Month 56)
measure: Time From Randomization to Conversion to Normal Glucose Homeostasis in Participants With Prediabetes at Baseline
timeFrame: Baseline up to end of study (Month 56)
measure: Time From Randomization to Conversion to T2DM for Participants Without Any Type of Diabetes at Baseline
timeFrame: Baseline up to end of study (Month 56)
measure: Change From Baseline in HbA1c at Month 6 in Participants With T2DM at Baseline
timeFrame: Baseline, and Month 6
measure: Time From Randomization to Event of New Onset Renal Impairment or Worsening Existing Renal Impairment in All Participants
timeFrame: Baseline up to end of study (Month 56)
measure: Time From Randomization to Event of New Onset Renal Impairment or Worsening Existing Renal Impairment in Participants With Prediabetes at Baseline
timeFrame: Baseline up to end of study (Month 56)
measure: Time From Randomization to Event of New Onset Renal Impairment or Worsening Existing Renal Impairment in Participants With T2DM at Baseline
timeFrame: Baseline up to end of study (Month 56)
measure: Time From Randomization to Event of Improvement in Renal Function in Participants With T2DM at Baseline
timeFrame: Baseline up to end of study (Month 56)
measure: Percentage of Participants Who Met FDA-Defined Valvulopathy in Echocardiographically Determined Heart Valve Changes
timeFrame: Months 6 and 12
measure: Percentage of Participants With FDA-Defined Valvulopathy at Baseline Who Demonstrated Worsened FDA-Defined Valvulopathy
timeFrame: Months 6 and 12
measure: Change From Baseline in Echocardiographically-Determined Pulmonary Arterial Systolic Pressure
timeFrame: Baseline, Month 12
Other outcomes:
Locations:
city: Alexander City
country: United States
facility: Advanced Cardiovascular, LLC
state: Alabama
city: Athens
country: United States
facility: North Alabama Research Center, LLC
state: Alabama
city: Birmingham
country: United States
facility: UAB Medical Center
state: Alabama
city: Mobile
country: United States
facility: Coastal Clinical Research, Inc.
state: Alabama
city: Mobile
country: United States
facility: Mobile Heart Specialists, PC
state: Alabama
city: Anchorage
country: United States
facility: Alaska Heart Institute
state: Alaska
city: Chandler
country: United States
facility: Connect Clinical Research Center, LCC
state: Arizona
city: Glendale
country: United States
facility: Arrowhead Health Centers
state: Arizona
city: Glendale
country: United States
facility: Phoenix Heart, PLLC
state: Arizona
city: Tucson
country: United States
facility: Eclipse Clinical Research
state: Arizona
city: Jonesboro
country: United States
facility: NEA Baptist Clinic
state: Arkansas
city: Little Rock
country: United States
facility: Arkansas Cardiology Clinic
state: Arkansas
city: Little Rock
country: United States
facility: Central Arkansas Veterans Healthcare System
state: Arkansas
city: Little Rock
country: United States
facility: Preferred Research Partners
state: Arkansas
city: Alhambra
country: United States
facility: Clinical Research Alliance
state: California
city: Bakersfield
country: United States
facility: Central Cardiology
state: California
city: Beverly Hills
country: United States
facility: Cardiovascular Research Foundation of Southern Cal
state: California
city: Carmichael
country: United States
facility: Capitol Interventional Cardiology
state: California
city: Chula Vista
country: United States
facility: San Diego Costal Endocrinology Group AMC
state: California
city: Concord
country: United States
facility: John Muir Physician Network Clinical Research Cent
state: California
city: Encino
country: United States
facility: Medical Group of Encino
state: California
city: Greenbrae
country: United States
facility: Marin Endocrine Care & Research, Inc.
state: California
city: Huntington Beach
country: United States
facility: California Heart Specialists
state: California
city: Huntington Park
country: United States
facility: Del Rosario Medical Clinic, Inc.
state: California
city: La Mesa
country: United States
facility: Diabetes and Endocrine Associates
state: California
city: La Mesa
country: United States
facility: La Mesa Cardiac Center
state: California
city: Laguna Hills
country: United States
facility: Alliance Research Centers
state: California
city: Lomita
country: United States
facility: Torrance Clinical Research Institute, Inc.
state: California
city: Long Beach
country: United States
facility: Long Beach Center for Clinical Research
state: California
city: Los Angeles
country: United States
facility: Metabolic Clinic and Research Center
state: California
city: Los Angeles
country: United States
facility: Beverly Hills Cardiology
state: California
city: Los Angeles
country: United States
facility: VA Greater Los Angeles Health Care System
state: California
city: Mission Viejo
country: United States
facility: Clinical Interventions Research Institute
state: California
city: Murrieta
country: United States
facility: Brigid Freyne MD Inc
state: California
city: Northridge
country: United States
facility: Valley Clinical Trials Inc
state: California
city: Oceanside
country: United States
facility: Carr Cardiology
state: California
city: Redding
country: United States
facility: Northern California Clinical Research Center
state: California
city: San Diego
country: United States
facility: Sharp Rees-Stealy Medical Group, Inc.
state: California
city: San Diego
country: United States
facility: University of California San Diego
state: California
city: San Diego
country: United States
facility: Ritchken and First MD's
state: California
city: San Ramon
country: United States
facility: West Coast Research LLC
state: California
city: Santa Ana
country: United States
facility: Coastal Multi-Specialty Research
state: California
city: Thousand Oaks
country: United States
facility: Westlake Medical Research
state: California
city: Torrance
country: United States
facility: Harbor - UCLA Medical Center
state: California
city: Ventura
country: United States
facility: Ronald Chochinov, MD
state: California
city: Ventura
country: United States
facility: Ventura Cardiology Consultants
state: California
city: West Hills
country: United States
facility: Infosphere Clinical Research
state: California
city: Colorado Springs
country: United States
facility: UCH-MHS Cardiac Research
state: Colorado
city: Denver
country: United States
facility: Creekside Endocrine Associates PC
state: Colorado
city: Golden
country: United States
facility: New West Physicians, PC
state: Colorado
city: Loveland
country: United States
facility: University of Colorado Health
state: Colorado
city: Bridgeport
country: United States
facility: Connecticut Clinical Research, LLC
state: Connecticut
city: Bridgeport
country: United States
facility: Bridgeport Hospital
state: Connecticut
city: Bristol
country: United States
facility: Clinical Research Works, Bristol
state: Connecticut
city: Norwalk
country: United States
facility: Cardiology Associates of Fairfield County, Norwalk
state: Connecticut
city: Stamford
country: United States
facility: Cardiology Associates of Fairfield County, P.C.
state: Connecticut
city: Stamford
country: United States
facility: Stamford Therapeutics Consortium
state: Connecticut
city: Trumbull
country: United States
facility: Cardiology Associates of Fairfield County, P.C.
state: Connecticut
city: Trumbull
country: United States
facility: Connecticut Heart and Vascular Center
state: Connecticut
city: Waterbury
country: United States
facility: Chase Medical Research, LLC
state: Connecticut
city: Newark
country: United States
facility: Red Clay Research
state: Delaware
city: Wilmington
country: United States
facility: Alfieri Cardiology
state: Delaware
city: Aventura
country: United States
facility: Aventura Heart Center
state: Florida
city: Boynton Beach
country: United States
facility: Zasa Clinical Research
state: Florida
city: Bradenton
country: United States
facility: Meridien Research
state: Florida
city: Bradenton
country: United States
facility: NOVA Southeastern University
state: Florida
city: Brandon
country: United States
facility: Bay Area Cardiology
state: Florida
city: Brooksville
country: United States
facility: Meridien Research, Brooksville
state: Florida
city: Clearwater
country: United States
facility: Clearwater Cardiovascular and Interventional Cons.
state: Florida
city: Coral Gables
country: United States
facility: Clinical Research of South Florida
state: Florida
city: Coral Springs
country: United States
facility: Holy Cross Medical Group
state: Florida
city: Daytona Beach
country: United States
facility: Cardiology Research Associates
state: Florida
city: Daytona Beach
country: United States
facility: International Medical Research
state: Florida
city: Doral
country: United States
facility: Asclepius Medical Research
state: Florida
city: Fleming Island
country: United States
facility: Fleming Island Center for Clinical Research
state: Florida
city: Fort Lauderdale
country: United States
facility: Integrative Research Associates, Inc.
state: Florida
city: Fort Lauderdale
country: United States
facility: M & O Clinical Research, LLC
state: Florida
city: Fort Myers
country: United States
facility: Primary Care Associates
state: Florida
city: Gainesville
country: United States
facility: Florida Research Network, LLC
state: Florida
city: Green Cove Springs
country: United States
facility: George E. Platt, M.D.
state: Florida
city: Hialeah
country: United States
facility: Eastern Research, Inc.
state: Florida
city: Hollywood
country: United States
facility: Larry K. Levinson, D.O., P.A.
state: Florida
city: Hollywood
country: United States
facility: Research Physicians Network Alliance
state: Florida
city: Hudson
country: United States
facility: Pasco Cardiology Center
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: University of Florida- Jacksonville
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Center for Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: Westside Center for Clinical Research
state: Florida
city: Lakeland
country: United States
facility: Meridien Research
state: Florida
city: Miami
country: United States
facility: Pharmax Research Clinic, Inc
state: Florida
city: Miami
country: United States
facility: Life Spring Research Foundation
state: Florida
city: Miami
country: United States
facility: United Clinical Research Corp.
state: Florida
city: Miami
country: United States
facility: Cardiovascular Research Center of South Florida
state: Florida
city: Miami
country: United States
facility: South Florida Research Group LLC
state: Florida
city: Miramar
country: United States
facility: South Florida Research Solutions
state: Florida
city: Naples
country: United States
facility: Southwest Florida Research
state: Florida
city: Ocala
country: United States
facility: Ocala Research Institute, Inc
state: Florida
city: Oviedo
country: United States
facility: Oviedo Medical Research
state: Florida
city: Palm Beach Gardens
country: United States
facility: Cardiology Partners Clinical Research Institute
state: Florida
city: Palm Beach Gardens
country: United States
facility: Palm Beach Gardens Research Center
state: Florida
city: Pembroke Pines
country: United States
facility: Research Physicians Network Alliance, Pembrok
state: Florida
city: Pembroke Pines
country: United States
facility: South Florida Research Solutions
state: Florida
city: Pensacola
country: United States
facility: Cardiology Consultants
state: Florida
city: Plant City
country: United States
facility: Clinical Research of Central Florida
state: Florida
city: Plantation
country: United States
facility: Columbia Primary Care, LLC d/b/a Heart and Health Institute
state: Florida
city: Ponte Vedra
country: United States
facility: St Johns Center for Clinical Research
state: Florida
city: Port Charlotte
country: United States
facility: Charlotte Heart Group Research Center
state: Florida
city: Port Orange
country: United States
facility: Progressive Medical Research
state: Florida
city: Rockledge
country: United States
facility: Brevard Cardiovascular Research Associates Inc
state: Florida
city: Safety Harbor
country: United States
facility: Clearwater Cardiovascular and Interventional Cons.
state: Florida
city: Saint Petersburg
country: United States
facility: Bayfront Health St. Petersburg, Research
state: Florida
city: Saint Petersburg
country: United States
facility: Meridien Research - St. Petersburg
state: Florida
city: Saint Petersburg
country: United States
facility: Professional Health Care of Pinellas, INC
state: Florida
city: Sarasota
country: United States
facility: Intercoastal Medical Group
state: Florida
city: Springfield
country: United States
facility: Springfield Medical Center
state: Florida
city: Stuart
country: United States
facility: Advanced Clinical Research Group
state: Florida
city: Tampa
country: United States
facility: Meridien Research - Tampa
state: Florida
city: Tampa
country: United States
facility: Stedman Clinical Trials
state: Florida
city: Tampa
country: United States
facility: Healthpoint Medical Group, Inc
state: Florida
city: Trinity
country: United States
facility: Interventional Cardiac Consultants
state: Florida
city: Venice
country: United States
facility: Lovelace Scientific Research
state: Florida
city: Vero Beach
country: United States
facility: Indian River Medical Center-Cardiology
state: Florida
city: Wellington
country: United States
facility: Cardiology Partners Clinical Research Institute
state: Florida
city: West Palm Beach
country: United States
facility: Cleveland Clinic Foundation
state: Florida
city: West Palm Beach
country: United States
facility: Metabolic Research Institute
state: Florida
city: Winter Haven
country: United States
facility: Clinical Research of Central Florida
state: Florida
city: Atlanta
country: United States
facility: Atlanta Diabetes Associates, Endocrinology
state: Georgia
city: Conyers
country: United States
facility: Rockdale Medical-Research Associates
state: Georgia
city: Cumming
country: United States
facility: Atlanta Heart Specialists
state: Georgia
city: Marietta
country: United States
facility: Urban Family Practice Associates/Clinical Research Advantage
state: Georgia
city: Roswell
country: United States
facility: Endocrine Research Solutions, Inc.
state: Georgia
city: Suwanee
country: United States
facility: Herman Clinical Research LLC
state: Georgia
city: Tucker
country: United States
facility: Atlanta Heart Specialists
state: Georgia
city: Arlington Heights
country: United States
facility: Northwest Heart Clinical Research, LLC
state: Illinois
city: Chicago
country: United States
facility: Cedar-Crosse Research Center
state: Illinois
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine
state: Illinois
city: Chicago
country: United States
facility: University of Chicago
state: Illinois
city: Elmhurst
country: United States
facility: Consultants in Cardiovascular Medicine
state: Illinois
city: Gurnee
country: United States
facility: Clinical Investigation Specialists, Inc. in Gurnee
state: Illinois
city: Rock Island
country: United States
facility: Advanced CardioVascular Consultants, SC
state: Illinois
city: Anderson
country: United States
facility: Community Clinical Research Center
state: Indiana
city: Avon
country: United States
facility: American Health Network of IN, LLC, Avon
state: Indiana
city: Bloomington
country: United States
facility: Premier Healthcare, LLC
state: Indiana
city: Evansville
country: United States
facility: Deaconess Clinic, Inc.
state: Indiana
city: Franklin
country: United States
facility: American Health Network of IN, LLC, Franklin
state: Indiana
city: Greenfield
country: United States
facility: American Health Network of IN, LLC, Greenfield
state: Indiana
city: Indianapolis
country: United States
facility: American Health Network - Thomas Moretto, MD
state: Indiana
city: Muncie
country: United States
facility: Medical Consultants PC
state: Indiana
city: Muncie
country: United States
facility: American Health Network of IN, LLC
state: Indiana
city: Munster
country: United States
facility: Cardiology Associates of Northwest Indiana, P.C
state: Indiana
city: Iowa City
country: United States
facility: The University of Iowa, College of Public Health
state: Iowa
city: Wichita
country: United States
facility: Professional Research Network of Kansas, LLC
state: Kansas
city: Louisville
country: United States
facility: Norton Heart Specialists
state: Kentucky
city: Louisville
country: United States
facility: Norton Heart Specialists
state: Kentucky
city: Louisville
country: United States
facility: L-MARC Research Center
state: Kentucky
city: Owensboro
country: United States
facility: Research Integrity LLC
state: Kentucky
city: Auburn
country: United States
facility: Central Maine Medical Center
state: Maine
city: Bangor
country: United States
facility: Acadia Clinical Research, LLC
state: Maine
city: Bangor
country: United States
facility: Eastern Maine Medical Center Northeast Cardiology Associates
state: Maine
city: Biddeford
country: United States
facility: Southern Maine Health Care/Maine Medical Center Research Ins
state: Maine
city: Portland
country: United States
facility: InterMed, PA
state: Maine
city: Annapolis
country: United States
facility: Medstar Cardiology Associates
state: Maryland
city: Baltimore
country: United States
facility: Chesapeake Cardiovascular Associates, GBMC
state: Maryland
city: Baltimore
country: United States
facility: Clinical Research, Inc
state: Maryland
city: Baltimore
country: United States
facility: Medstar Union Memorial Heart Specialists
state: Maryland
city: Baltimore
country: United States
facility: Medstar Union Memorial Hospital
state: Maryland
city: Baltimore
country: United States
facility: Spectrum Clinical Research
state: Maryland
city: Baltimore
country: United States
facility: Overlea Personal Physicians
state: Maryland
city: Baltimore
country: United States
facility: Shahid Saeed MD, PC
state: Maryland
city: Glen Burnie
country: United States
facility: Maryland Heart Associates, LLC
state: Maryland
city: Hagerstown
country: United States
facility: Klein & Associates, MD, PA
state: Maryland
city: Hyattsville
country: United States
facility: MedStar Health Research Institute
state: Maryland
city: Lutherville
country: United States
facility: Lutherville Personal Physicians
state: Maryland
city: Oxon Hill
country: United States
facility: MD Medical Research
state: Maryland
city: Rockville
country: United States
facility: Endocrine & Metabolic Consultants
state: Maryland
city: Towson
country: United States
facility: Lutherville Personal Physicians
state: Maryland
city: Towson
country: United States
facility: Overlea Personal Physicians
state: Maryland
city: Boston
country: United States
facility: Tufts Medical Center
state: Massachusetts
city: Boston
country: United States
facility: MGH Weight Center
state: Massachusetts
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
city: Fall River
country: United States
facility: New England Center for Clinical Research, IMCA
state: Massachusetts
city: Haverhill
country: United States
facility: Pentucket Medical Associates
state: Massachusetts
city: Methuen
country: United States
facility: ActivMed Practices
state: Massachusetts
city: Natick
country: United States
facility: Partners Community Physicians Organization
state: Massachusetts
city: Needham
country: United States
facility: Partners Community Physicians Organization
state: Massachusetts
city: Alpena
country: United States
facility: Endeavor Medical Research PLC
state: Michigan
city: Cadillac
country: United States
facility: Cadillac Clinical Research, LLC
state: Michigan
city: Kalamazoo
country: United States
facility: Westside Family Medical Center, PC
state: Michigan
city: Lapeer
country: United States
facility: Cardiology Consultants of East Michigan
state: Michigan
city: Marquette
country: United States
facility: Marquette General Heart and Vascular Institute
state: Michigan
city: Midland
country: United States
facility: MidMichigan Medical Center
state: Michigan
city: Petoskey
country: United States
facility: Nisus Research at McLaren Northern Michigan Hospital
state: Michigan
city: Pontiac
country: United States
facility: Saint Joseph Mercy Oakland Hospital
state: Michigan
city: Rochester
country: United States
facility: Remedica LLC
state: Michigan
city: Saginaw
country: United States
facility: Michigan CardioVascular Institute
state: Michigan
city: Southfield
country: United States
facility: American Center for Clinical Trials
state: Michigan
city: Traverse City
country: United States
facility: Medical Research Associates, Inc.
state: Michigan
city: Ypsilanti
country: United States
facility: Michigan Heart
state: Michigan
city: Baxter
country: United States
facility: Minneapolis Heart Institute Foundation
state: Minnesota
city: Duluth
country: United States
facility: Essentia Institute of Rural Health
state: Minnesota
city: Eagan
country: United States
facility: MNCOME Clinic
state: Minnesota
city: Edina
country: United States
facility: Radiant Research, Inc.
state: Minnesota
city: Minneapolis
country: United States
facility: Minneapolis Heart Institute
state: Minnesota
city: Saint Paul
country: United States
facility: Regions Hospital
state: Minnesota
city: Gulfport
country: United States
facility: Coast Cardiovascular Consultants PLLC
state: Mississippi
city: Tupelo
country: United States
facility: Cardiology Associates Research, LLC
state: Mississippi
city: Chesterfield
country: United States
facility: Diabetes & Endocrinology Specialists, Inc.
state: Missouri
city: Washington
country: United States
facility: BodyAesthetic Research Center
state: Missouri
city: Billings
country: United States
facility: Billings Clinic Research Center
state: Montana
city: Billings
country: United States
facility: Montana Health Research Institute, Inc.
state: Montana
city: Kalispell
country: United States
facility: Glacier View Cardiology PC
state: Montana
city: Grand Island
country: United States
facility: Internal Medical Associates of Grand Island, PC
state: Nebraska
city: Henderson
country: United States
facility: Clinical Research Advantage / Rita Chuang, M.D.
state: Nevada
city: Las Vegas
country: United States
facility: Clinical Research Advantage, Inc.
state: Nevada
city: Las Vegas
country: United States
facility: Clinical Research of South Nevada
state: Nevada
city: Bridgewater
country: United States
facility: Medicor Cardiology, PA
state: New Jersey
city: Bridgewater
country: United States
facility: Advanced Heart Care
state: New Jersey
city: East Brunswick
country: United States
facility: UmiMed Center LLC
state: New Jersey
city: Elmer
country: United States
facility: Cardiovascular Associates of the Delaware Valley
state: New Jersey
city: Haddon Heights
country: United States
facility: Advocare Heights Primary Care
state: New Jersey
city: Haddon Heights
country: United States
facility: Cardiovascular Associates of the Delaware Valley P
state: New Jersey
city: Linden
country: United States
facility: NJ Heart
state: New Jersey
city: Mine Hill
country: United States
facility: Rutgers New Jersey Medical School
state: New Jersey
city: Sewell
country: United States
facility: Cardiovascular Associates Delaware Valley Sewell
state: New Jersey
city: Somerset
country: United States
facility: Cardio Metabolic Institute
state: New Jersey
city: Albuquerque
country: United States
facility: New Mexico Heart Institute, PA
state: New Mexico
city: Albany
country: United States
facility: Albany College of Medicine, Division of Endocrinology
state: New York
city: Albany
country: United States
facility: Capital Cardiology Associates
state: New York
city: Binghamton
country: United States
facility: United Medical Associates, PC
state: New York
city: Bronx
country: United States
facility: James J. Peters VA Medical Center, Bronx, NY
state: New York
city: Buffalo
country: United States
facility: Buffalo Heart Group
state: New York
city: Endwell
country: United States
facility: Regional Clinical Research, Inc.
state: New York
city: Great Neck
country: United States
facility: Long Island Gastrointestinal Research Group LLP
state: New York
city: Mineola
country: United States
facility: Long Island Heart Associates
state: New York
city: New Hyde Park
country: United States
facility: North Shore Diabetes and Endocrine Associates
state: New York
city: New York
country: United States
facility: Weill Cornell Medical College
state: New York
city: North Massapequa
country: United States
facility: DiGiovanna Institute for Medical Education
state: New York
city: Poughkeepsie
country: United States
facility: Hudson Valley Heart Center
state: New York
city: Rochester
country: United States
facility: Rochester Clinical Research, Inc.
state: New York
city: Southampton
country: United States
facility: Northwell Health Physician Partners Cardiology
state: New York
city: Troy
country: United States
facility: Capital Cardiology Associates
state: New York
city: Westfield
country: United States
facility: Great Lakes Medical Research
state: New York
city: Burlington
country: United States
facility: Kernodle Clinic
state: North Carolina
city: Cary
country: United States
facility: Clinical Trials of America Inc.
state: North Carolina
city: Charlotte
country: United States
facility: Metrolina Internal Medicine
state: North Carolina
city: Charlotte
country: United States
facility: PMG Research of Charlotte, LLC
state: North Carolina
city: Greensboro
country: United States
facility: Bland Clinic, PA
state: North Carolina
city: Hickory
country: United States
facility: Clinical Trials of America Inc. Hickory
state: North Carolina
city: Hickory
country: United States
facility: Clinical Trials of America, Inc.
state: North Carolina
city: High Point
country: United States
facility: Peters Medical Research
state: North Carolina
city: Lenoir
country: United States
facility: Clinical Trials of America, Inc.
state: North Carolina
city: Morehead City
country: United States
facility: Diabetes & Endocrinology Consultants
state: North Carolina
city: Morganton
country: United States
facility: Burke Primary Care
state: North Carolina
city: Pinehurst
country: United States
facility: Pinehurst Medical Clinic, Inc.
state: North Carolina
city: Raleigh
country: United States
facility: Wake Research Associates, LLC
state: North Carolina
city: Rocky Mount
country: United States
facility: PMG Research of Rocky Mount
state: North Carolina
city: Salisbury
country: United States
facility: PMG Research of Salisbury
state: North Carolina
city: Sanford
country: United States
facility: Sanford Cardiology
state: North Carolina
city: Statesville
country: United States
facility: Piedmont Healthcare
state: North Carolina
city: Wilmington
country: United States
facility: PMG Research of Wilmington
state: North Carolina
city: Winston-Salem
country: United States
facility: PMG Research of Winston-Salem, LLC
state: North Carolina
city: Fargo
country: United States
facility: Lillestol Research LLC
state: North Dakota
city: Canton
country: United States
facility: Aultman Hospital
state: Ohio
city: Cincinnati
country: United States
facility: The Lindner Research Center
state: Ohio
city: Cincinnati
country: United States
facility: Sentral Clinical Research
state: Ohio
city: Delaware
country: United States
facility: Delaware Research Group, LLC
state: Ohio
city: Marion
country: United States
facility: Awasty Research Network, LLC
state: Ohio
city: Massillon
country: United States
facility: Community Health Care
state: Ohio
city: Springfield
country: United States
facility: Apex Medical Research Inc.
state: Ohio
city: Oklahoma City
country: United States
facility: Integris Cardiovascular Physicians LLC
state: Oklahoma
city: Oklahoma City
country: United States
facility: Memorial Clinical Research
state: Oklahoma
city: Oklahoma City
country: United States
facility: South Oklahoma Heart Research, LLC
state: Oklahoma
city: Tulsa
country: United States
facility: Oklahoma Heart Institute
state: Oklahoma
city: Tulsa
country: United States
facility: Vital Prospects Clinical Research Institute PC
state: Oklahoma
city: Altoona
country: United States
facility: Blair Medical Associates
state: Pennsylvania
city: Altoona
country: United States
facility: Clinical Research Associates of Central PA, LLC
state: Pennsylvania
city: Camp Hill
country: United States
facility: Capital Area Research, LLC
state: Pennsylvania
city: Danville
country: United States
facility: Geisinger Health Clinic
state: Pennsylvania
city: Danville
country: United States
facility: Geisinger Health System
state: Pennsylvania
city: Doylestown
country: United States
facility: Doylestown Health Cardiology a Division of Doylestown Health
state: Pennsylvania
city: Duncansville
country: United States
facility: Altoona Center for Clinical Research
state: Pennsylvania
city: Erie
country: United States
facility: Liberty Family Practice
state: Pennsylvania
city: Feasterville
country: United States
facility: Endocrine Clinical Research LLC
state: Pennsylvania
city: Indiana
country: United States
facility: Joseph Lamantia, DO
state: Pennsylvania
city: Jenkintown
country: United States
facility: The Clinical Trial Center, LLC
state: Pennsylvania
city: Jersey Shore
country: United States
facility: Lycoming Internal Medicine, Inc.
state: Pennsylvania
city: Johnstown
country: United States
facility: Berkley Hills Clinicals
state: Pennsylvania
city: Johnstown
country: United States
facility: Ilumina Clinical Associates, Johnstown
state: Pennsylvania
city: Johnstown
country: United States
facility: Joseph Lamantia, DO
state: Pennsylvania
city: Langhorne
country: United States
facility: Comprehensive Cardiology Consultants
state: Pennsylvania
city: Lansdale
country: United States
facility: Detweiler Family Medicine and Associates PC
state: Pennsylvania
city: Lansdale
country: United States
facility: Green & Seidner Family Practice Associates
state: Pennsylvania
city: Newport
country: United States
facility: Capital Area Research LLC
state: Pennsylvania
city: Philadelphia
country: United States
facility: Endocrine Metabolic Associates
state: Pennsylvania
city: Pottstown
country: United States
facility: Pottstown Medical Specialists, Inc. (PMSI)
state: Pennsylvania
city: Scranton
country: United States
facility: Geisinger Clinic
state: Pennsylvania
city: Cumberland
country: United States
facility: Partners in Clinical Research
state: Rhode Island
city: Greer
country: United States
facility: Radiant Research, Inc.
state: South Carolina
city: Greer
country: United States
facility: Mountain View Clinical Research
state: South Carolina
city: Spartanburg
country: United States
facility: Palmetto Research Center, LLC
state: South Carolina
city: Watertown
country: United States
facility: Brown Clinic, PLLP
state: South Dakota
city: Bristol
country: United States
facility: PMG Research of Bristol, LLC
state: Tennessee
city: Chattanooga
country: United States
facility: Chattanooga Research and Medicine (CHARM)
state: Tennessee
city: Chattanooga
country: United States
facility: WR-ClinSearch, LLC
state: Tennessee
city: Greeneville
country: United States
facility: Wellmont CVA Heart Institute
state: Tennessee
city: Jackson
country: United States
facility: Research Associates of Jackson
state: Tennessee
city: Jackson
country: United States
facility: Kore Cardiovascular Research
state: Tennessee
city: Jackson
country: United States
facility: The Jackson Clinic, PA
state: Tennessee
city: Johnson City
country: United States
facility: Wellmont CVA Heart Institute
state: Tennessee
city: Kingsport
country: United States
facility: Holston Medical Group
state: Tennessee
city: Kingsport
country: United States
facility: Wellmont CVA Heart Institute
state: Tennessee
city: Memphis
country: United States
facility: The Endocrine Clinic
state: Tennessee
city: Nashville
country: United States
facility: Cardiology Wellness Center
state: Tennessee
city: Austin
country: United States
facility: Central Texas Clinical Research, LLC
state: Texas
city: Austin
country: United States
facility: Texas Diabetes & Endocrinology
state: Texas
city: Carrollton
country: United States
facility: Texas Health Physicians Group
state: Texas
city: Corpus Christi
country: United States
facility: Adriana Pop-Moody MD Clinic, PA
state: Texas
city: Dallas
country: United States
facility: Baylor Research Institute
state: Texas
city: Dallas
country: United States
facility: Texas Health Physicians Group
state: Texas
city: Dallas
country: United States
facility: Texas Health Physicians Group, Dallas
state: Texas
city: Dallas
country: United States
facility: Research Institute of Dallas
state: Texas
city: Fort Worth
country: United States
facility: Odilon Alvarado, M.D.
state: Texas
city: Fort Worth
country: United States
facility: Texas Health Physicians Group Fort Worth
state: Texas
city: Fort Worth
country: United States
facility: Tand R Clinic, PA
state: Texas
city: Georgetown
country: United States
facility: San Gabriel Clinical Research, LLC
state: Texas
city: Houston
country: United States
facility: Angiocardiac Care of Texas PA
state: Texas
city: Houston
country: United States
facility: Oxford Clinical Research, LLC
state: Texas
city: Houston
country: United States
facility: West Houston Area Clinical Trial Consultants, LLC
state: Texas
city: Houston
country: United States
facility: Endocrine and Psychiatry Center
state: Texas
city: Irving
country: United States
facility: Texas Health Physicians Group
state: Texas
city: Kingwood
country: United States
facility: Texas Cardiology Associates of Houston
state: Texas
city: Lewisville
country: United States
facility: Jalil Aziz Khan M.D., P.A.
state: Texas
city: Midland
country: United States
facility: Midland Clinical Research Center
state: Texas
city: Odessa
country: United States
facility: Permian Research Foundation
state: Texas
city: Plano
country: United States
facility: Medical Clinic of North Texas
state: Texas
city: Plano
country: United States
facility: Clinical Investigations of Texas, LLC
state: Texas
city: Round Rock
country: United States
facility: Texas Diabetes
state: Texas
city: San Antonio
country: United States
facility: Physician PrimeCare Research Institute, PLLC
state: Texas
city: San Antonio
country: United States
facility: Cardiology Clinic of San Antonio
state: Texas
city: San Antonio
country: United States
facility: Radiant Research San Antonio
state: Texas
city: Tomball
country: United States
facility: Martin Diagnostic Clinic
state: Texas
city: Tyler
country: United States
facility: Cardiovascular Associates of East Texas
state: Texas
city: Webster
country: United States
facility: Bay Area Total Health Medical Group
state: Texas
city: Ogden
country: United States
facility: Advanced Research Institute
state: Utah
city: Salt Lake City
country: United States
facility: Jean Brown Research
state: Utah
city: Alexandria
country: United States
facility: Alexandria Clinical Research, LLC
state: Virginia
city: Arlington
country: United States
facility: Washington Center for Weight Management and Resear
state: Virginia
city: Burke
country: United States
facility: Burke Internal Medicine and Research
state: Virginia
city: Danville
country: United States
facility: Cardiology Consultants of Danville, Inc.
state: Virginia
city: Danville
country: United States
facility: Danville Internal Medicine, Inc
state: Virginia
city: Falls Church
country: United States
facility: Virginia Heart
state: Virginia
city: Falls Church
country: United States
facility: Seven Corners Medical Research Center
state: Virginia
city: Manassas
country: United States
facility: INOVA Health Care Services
state: Virginia
city: Manassas
country: United States
facility: Burke Internal Medicine and Research
state: Virginia
city: Manassas
country: United States
facility: Manassas Clinical Research Center
state: Virginia
city: Norfolk
country: United States
facility: Health Research of Hampton Roads - Norfolk, Inc.
state: Virginia
city: Norfolk
country: United States
facility: Clinical Research Associates of Tidewater
state: Virginia
city: Richmond
country: United States
facility: Clinical Research Partners
state: Virginia
city: Richmond
country: United States
facility: Virginia Cardiovascular Specialists
state: Virginia
city: Richmond
country: United States
facility: National Clinical Research-Richmond, Inc
state: Virginia
city: Winchester
country: United States
facility: Selma Medical Associates
state: Virginia
city: Federal Way
country: United States
facility: Larry D. Stonesifer, MD, Inc PS
state: Washington
city: Seattle
country: United States
facility: Seattle Women's
state: Washington
city: Spokane
country: United States
facility: Rowan Research Inc.
state: Washington
city: Tacoma
country: United States
facility: MultiCare Research Institute
state: Washington
city: Tacoma
country: United States
facility: Universal Research Group
state: Washington
city: Wenatchee
country: United States
facility: Wenatchee Valley Hospital & Clinics
state: Washington
city: Green Bay
country: United States
facility: Cardiology Associates of Bellin Health
state: Wisconsin
city: Green Bay
country: United States
facility: Prevea Clinic, Inc
state: Wisconsin
city: Kenosha
country: United States
facility: Clinical Investigation Specialists, Inc.
state: Wisconsin
city: Madison
country: United States
facility: Meriter hospital Inc., DBA: UnityPoint Health-Meriter Heart
state: Wisconsin
city: Marshfield
country: United States
facility: Marshfield Clinic
state: Wisconsin
city: Wausau
country: United States
facility: Aspirus Research Institute
state: Wisconsin
city: Coffs Harbour
country: Australia
facility: Coffs Harbour Health Campus
state: New South Wales
city: Gosford
country: Australia
facility: Gosford Hospital, Cardiology Clinical Trials
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital
state: New South Wales
city: Wollongong
country: Australia
facility: Illawarra Shoalhaven Local Health District, Clinical Trial and Research Unit
state: New South Wales
city: Wollongong
country: Australia
facility: Wollongong Hospital
state: New South Wales
city: Brisbane
country: Australia
facility: Core Research Group
state: Queensland
city: Brisbane
country: Australia
facility: Princess Alexandra Hospital, Cardiology Research Department
state: Queensland
city: Herston
country: Australia
facility: Royal Brisbane and Women's Hospital, Endocrinology Department
state: Queensland
city: Milton
country: Australia
facility: HeartCare Partners Clinical Research Unit
state: Queensland
city: Sherwood
country: Australia
facility: AusTrials Pty Ltd
state: Queensland
city: Southport
country: Australia
facility: Gold Coast Hospital, Cardiovascular Research Centre
state: Queensland
city: Adelaide
country: Australia
facility: New Royal Adelaide Hospital, Cardiology Department
state: South Australia
city: Ashford
country: Australia
facility: Adelaide Medical Research
state: South Australia
city: Elizabeth Vale
country: Australia
facility: Lyell McEwin Hospital, Department of Cardiology
state: South Australia
city: Fullarton
country: Australia
facility: Heart and Vascular Institute
state: South Australia
city: Woodville South
country: Australia
facility: The Queen Elizabeth Hospital
state: South Australia
city: Ballarat
country: Australia
facility: Ballarat Health Services
state: Victoria
city: Geelong
country: Australia
facility: Geelong Cardiology Research Unit, Barwon Health
state: Victoria
city: Heidelberg Heights
country: Australia
facility: Austin Health - Heidelberg Repatriation Hospital, Department of Medicine, Boronia Centre
state: Victoria
city: Saint Kilda East
country: Australia
facility: Avenue Cardiovascular Centre
state: Victoria
city: Joondalup
country: Australia
facility: Joondalup Cardiovascular Trials Foundation Inc
state: Western Australia
city: Murdoch
country: Australia
facility: Fiona Stanley Hospital, Cardiology Research Department,CDO11
state: Western Australia
city: Adelaide
country: Australia
facility: South Australian Medical Research Inst, Centre for Clinical Research
city: Nassau
country: Bahamas
facility: The Partners Clinical Research Centre
city: Calgary
country: Canada
facility: LMC Clinical Research Inc. (Calgary)
state: Alberta
city: Vancouver
country: Canada
facility: Gordon and Leslie Diamond Health Care Centre
state: British Columbia
city: Halifax
country: Canada
facility: Nova Scotia Health Authority /QEII Health Sciences Centre
state: Nova Scotia
city: Brampton
country: Canada
facility: LMC Diabetes & Endocrinology - Brampton
state: Ontario
city: Brampton
country: Canada
facility: McMaster University
state: Ontario
city: Burlington
country: Canada
facility: JBN Medical Diagnostic Services Inc.
state: Ontario
city: Burlington
country: Canada
facility: Aviva Clinical Trial Group In.
state: Ontario
city: Cambridge
country: Canada
facility: Cambridge Cardiac Care Centre
state: Ontario
city: Cambridge
country: Canada
facility: Joanne F. Liutkus Medicine Professional Corp.
state: Ontario
city: Cambridge
country: Canada
facility: Saul Vizel Professional Medicine Corporation, Vizel Cardiac Research
state: Ontario
city: Etobicoke
country: Canada
facility: LMC Diabetes & Endocrinology (Etobicoke)
state: Ontario
city: Hamilton
country: Canada
facility: Wharton Medical Clinic Clinical Trials Group Inc.
state: Ontario
city: London
country: Canada
facility: Saint Josephs Health Care London
state: Ontario
city: Markham
country: Canada
facility: LMC Diabetes & Endocrinoly
state: Ontario
city: Newmarket
country: Canada
facility: New Market Cardiology Research Group
state: Ontario
city: Oakville
country: Canada
facility: Dr. Michael Heffernan
state: Ontario
city: Oakville
country: Canada
facility: LMC Clinical Research Inc. (Oakville)
state: Ontario
city: Oshawa
country: Canada
facility: Dr. Cha
state: Ontario
city: Ottawa
country: Canada
facility: University of Ottawa Heart Institute
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Cardiology Clinical Trials
state: Ontario
city: Sudbury
country: Canada
facility: Dr. Dinkar Shukla Professional Medicine Corporation
state: Ontario
city: Sudbury
country: Canada
facility: Dr Roger Labonte Professional Medicine Corp
state: Ontario
city: Thornhill
country: Canada
facility: LMC Diabetes & Endocrinology (Thornhill)
state: Ontario
city: Toronto
country: Canada
facility: JJ DIG Research Ltd.
state: Ontario
city: Toronto
country: Canada
facility: Keele Medical Place
state: Ontario
city: Toronto
country: Canada
facility: LMC Clinical Research Inc. (Bayview)
state: Ontario
city: Toronto
country: Canada
facility: St Michael's Hospital Health Centre
state: Ontario
city: Brossard
country: Canada
facility: ViaCar Recherche Clinique
state: Quebec
city: Gatineau
country: Canada
facility: Q&T Research Outaouais Inc.
state: Quebec
city: Greenfield Park
country: Canada
facility: ViaCar Recherche Clinique Inc.
state: Quebec
city: Levis
country: Canada
facility: Manna Research Inc
state: Quebec
city: Montreal
country: Canada
facility: Clinique Sante Cardio MC
state: Quebec
city: Quebec City
country: Canada
facility: Universitaire de Cardiologie et de Pneumologie de Quebec
state: Quebec
city: Saint-Charles-Borromee
country: Canada
facility: Centre hospitalier régional de Lanaudière
state: Quebec
city: Sherbrooke
country: Canada
facility: Recherche Clinique London
state: Quebec
city: St Jean sur Richelieu
country: Canada
facility: CardioVasc HR, Inc.
state: Quebec
city: St-Lambert
country: Canada
facility: ViaCar Recherche Clinique Inc.
state: Quebec
city: Ville Saint-Laurent
country: Canada
facility: LMC Clinical Research Inc. (Montreal)
state: Quebec
city: Providencia
country: Chile
facility: Biomedica Research Group
state: Santiago
city: San Miguel
country: Chile
facility: Sociedad Medica Cardiologica El Llano
state: Santiago
city: Concepcion
country: Chile
facility: Hospital Regional Concepcion
city: Santiago
country: Chile
facility: Cardiocob
city: Santiago
country: Chile
facility: Servicios Medicos Godoy Ltda.
city: Santiago
country: Chile
facility: Ccbr Cecim
city: Temuco
country: Chile
facility: Centro Investigacion Clinica del Sur
city: Temuco
country: Chile
facility: CECMI Ltda.
city: Guadalajara
country: Mexico
facility: ICLE
state: Jalisco
city: Guadalajara
country: Mexico
facility: Private Medical Practice
state: Jalisco
city: Monterrey
country: Mexico
facility: IMED Clin Trials
state: Nuevo Leon
city: Monterrey
country: Mexico
facility: Cardiolink ClinTrials S.C.
state: Nuevo Leon
city: Monterrey
country: Mexico
facility: Centro de Estudios Clinicos y Especialidades Medicas S.C.
state: Nuevo Leon
city: Xalapa
country: Mexico
facility: Hospital de Angeles Xalapa
state: Veracruz
city: Aguascalientes
country: Mexico
facility: Fundacion Cardiovascular de Aguascalientes
city: Aguascalientes
country: Mexico
facility: Hospital Cardiologica Aguascalientes
city: Distrito Federal
country: Mexico
facility: Mentrials S.A.de C.V.
city: Milford
country: New Zealand
facility: North Shore Hospital-Cardiology Research
state: Auckland
city: Papatoetoe
country: New Zealand
facility: Middlemore Hospital
state: Auckland
city: Takapuna
country: New Zealand
facility: North Shore Hospital - Diabetes Clinic
state: Auckland
city: Christchurch
country: New Zealand
facility: Christchurch Hospital, Lipids
state: Canterbury
city: Christchurch
country: New Zealand
facility: Christchurch Hospital, Cardiology Research
state: Canterbury
city: Dunedin
country: New Zealand
facility: Dunedin Hospital
state: Otago
city: New Plymouth
country: New Zealand
facility: Taranaki Base Hospital
state: Taranaki
city: Lower Hutt
country: New Zealand
facility: Hutt Hospital, Cardiology Dept
state: Wellington
city: Auckland
country: New Zealand
facility: Auckland City Hospital
city: Hastings
country: New Zealand
facility: Hawkes Bay Regional Hospital
city: Nelson
country: New Zealand
facility: Nelson Hospital, Cardiology Department
city: Rotorua
country: New Zealand
facility: Lakeland Clinical Trials, Rotorua
city: Tauranga
country: New Zealand
facility: Tauranga Hospital
city: Bezrzecze
country: Poland
facility: Indywidualna Specjalistyczna Praktyka Lekarska
city: Biala Rawska
country: Poland
facility: NZOZ "Eskulap"
city: Białystok
country: Poland
facility: Podlaski Osrodek Kardiologii Janusz Korecki
city: Bydgoszcz
country: Poland
facility: Centrum Medyczne KERmed
city: Bydgoszcz
country: Poland
facility: 10 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ
city: Chorzów
country: Poland
facility: Nzoz "Mada-Med"
city: Chrzanów
country: Poland
facility: DIABET Centrum Medyczne s. c.
city: Gdynia
country: Poland
facility: ISPL w Dziedzinie Kardiologii lek.med. Krzysztof Cymerman
city: Gdynia
country: Poland
facility: NZOZ SCBK ProCordis
city: Gdynia
country: Poland
facility: Gabinet Kardiologiczno-Internistyczny
city: Inowroclaw
country: Poland
facility: Praktyka Lekarska dr n. med. Marek Bronisz
city: Kamieniec Ząbkowicki
country: Poland
facility: Piotr Mader Diabetic Clinic NZOZ PD-I
city: Koluszki
country: Poland
facility: NZOZ Eskulap SC
city: Kraków
country: Poland
facility: Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
city: Kraków
country: Poland
facility: LANDA' Specjalistyczne Gabinety Lekarskie
city: Kraków
country: Poland
facility: Medyczne Centrum Diabetologiczno Endokrynologiczno
city: Legnica
country: Poland
facility: Nzoz Cardiamed
city: Lublin
country: Poland
facility: "CenterMed Lublin" Sp. z o.o.
city: Mrągowo
country: Poland
facility: Indywidualna Praktyka Lekarska
city: Olsztyn
country: Poland
facility: Zechowicz MEDEUSZ-PLUS
city: Poznań
country: Poland
facility: Praktyka Lekarska Ewa Krzyzagorska
city: Poznań
country: Poland
facility: NZOZ NEURO-KARD "Ilkowski i Partnerzy"
city: Płock
country: Poland
facility: Specjalistyczna Przychodnia Lekarska MEDIKARD (SPL Medikard)
city: Tarnów
country: Poland
facility: Specjalistyczny Gabinet Lekarski
city: Toruń
country: Poland
facility: Lecznice Citomed Sp. z o.o.
city: Toruń
country: Poland
facility: Praktyka Lekarska Pawlowicz Lidia
city: Warszawa
country: Poland
facility: Centrum Medyczne AMED
city: Warszawa
country: Poland
facility: Centrum Badawcze Wspolczesnej Terapii
city: Warszawa
country: Poland
facility: SNZOZ Fundacji PROCLINICA
city: Wierzchosławice
country: Poland
facility: Centrum Zdrowia Wierzchoslawice
city: Wroclaw
country: Poland
facility: Regionalna Poradnia Diabetologiczna
city: Włocławek
country: Poland
facility: Specjalistyczne Gabinety Lekarskie "Medicor PLUS"
city: Łódź
country: Poland
facility: NZOZ ALL-MED Centrum Medyczne
city: Łęczna
country: Poland
facility: SP ZOZ w Lecznej
Study officials:
References:
citation: Scirica BM, Bohula EA, Dwyer JP, Qamar A, Inzucchi SE, McGuire DK, Keech AC, Smith SR, Murphy SA, Im K, Leiter LA, Gupta M, Patel T, Miao W, Perdomo C, Bonaca MP, Ruff CT, Sabatine MS, Wiviott SD; CAMELLIA-TIMI 61 Steering Committee and Investigators. Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial. Circulation. 2019 Jan 15;139(3):366-375. doi: 10.1161/CIRCULATIONAHA.118.038341.
citation: Bohula EA, Scirica BM, Inzucchi SE, McGuire DK, Keech AC, Smith SR, Kanevsky E, Murphy SA, Leiter LA, Dwyer JP, Corbalan R, Hamm C, Kaplan L, Nicolau JC, Ophuis TO, Ray KK, Ruda M, Spinar J, Patel T, Miao W, Perdomo C, Francis B, Dhadda S, Bonaca MP, Ruff CT, Sabatine MS, Wiviott SD; CAMELLIA-TIMI 61 Steering Committee Investigators. Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial. Lancet. 2018 Nov 24;392(10161):2269-2279. doi: 10.1016/S0140-6736(18)32328-6. Epub 2018 Oct 4.
citation: Bohula EA, Wiviott SD, McGuire DK, Inzucchi SE, Kuder J, Im K, Fanola CL, Qamar A, Brown C, Budaj A, Garcia-Castillo A, Gupta M, Leiter LA, Weissman NJ, White HD, Patel T, Francis B, Miao W, Perdomo C, Dhadda S, Bonaca MP, Ruff CT, Keech AC, Smith SR, Sabatine MS, Scirica BM; CAMELLIA-TIMI 61 Steering Committee and Investigators. Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients. N Engl J Med. 2018 Sep 20;379(12):1107-1117. doi: 10.1056/NEJMoa1808721. Epub 2018 Aug 26.
citation: Bohula EA, Scirica BM, Fanola C, Inzucchi SE, Keech A, McGuire DK, Smith SR, Abrahamsen T, Francis BH, Miao W, Perdomo CA, Satlin A, Wiviott SD, Sabatine MS. Design and rationale for the Cardiovascular and Metabolic Effects of Lorcaserin in Overweight and Obese Patients-Thrombolysis in Myocardial Infarction 61 (CAMELLIA-TIMI 61) trial. Am Heart J. 2018 Aug;202:39-48. doi: 10.1016/j.ahj.2018.03.012. Epub 2018 Mar 29.