Clinical trial NCT03918902: Snuff Use, Smoking, Periodontitis and Mortality: 30-year Cohort Study From Sweden
Official title: Snuff Use, Smoking, Periodontitis and Mortality: 30-year Cohort Study From Sweden
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tobacco Use
Periodontitis
Keywords: mortality
oral hygiene
periodontitis
smokeless tobacco
tobacco
Lead sponsor: University of Helsinki
Sponsor class: OTHER
Collaborators: name: Karolinska Institutet
First posted: 2019-04-18
Enrollment: 1080
Sex: ALL
Minimum age (years): 31
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Swedish national database sample

Brief summary: Smoking and dual using associated with poor periodontal health.

Detailed description: Aim: To investigate how snuff use, smoking and risk behaviour affect periodontal health and mortality in a Swedish cohort, hypothesizing that they indeed have a poor impact and increase the risk of death.

Material and methods: Study cohort of 1080 subjects aged 31 to 40 years (528 men and 552 women) from Stockholm area was clinically examined in 1985 and followed for mortality until 2015. Associations between periodontal health parameters, snuff use, smoking and age of death were analysed by classifying all subjects into four groups: "dual-users" (current snuffers and current smokers); "pure snuffers" (current non-smoking snuffers); "pure smokers" (current non-snuffing smokers) and "non-users" (non-snuffers, non-smokers). SPSS was used for analyses.

Eligibility criteria: Inclusion Criteria:

* In 1985-1986 a sample was selected from the registry file of all inhabitants of the Stockholm area, of people born on the 20th of any month from 1945 to 1954.The sample comprised 3200 people. They were informed about the purpose of the study and called for clinical investigation. 1681 (52.5%) individuals, 840 men and 841 women, participated in the study. Subjects had different socio-economic and health backgrounds.

Exclusion Criteria:

* Other people. Any disease was not an exclusion criteria.

Primary outcomes:
measure: Deep periodontal pockets (5mm or over)
timeFrame: 1985
measure: Calculus index
timeFrame: 1985
measure: Missing teeth
timeFrame: 1985
measure: Premature death
timeFrame: From year 1985 to year 2015
measure: Plaque index
timeFrame: 1985
measure: Gingival index
timeFrame: 1985
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
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