Clinical trial NCT02444364: Effects of DPP-4 Inhibition on Calcium and Bone Metabolism in Type 2 Diabetes Mellitus
Official title: Pilot Project Evaluation of the DPP-4 Inhibition With Sitagliptin on Calcium and Bone Metabolism in Patients With Type 2 Diabetes Mellitus
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: EARLY_PHASE1
Conditions: Type 2 Diabetes
Keywords: diabetes
bone loss
Bone Density
Lead sponsor: University of Missouri-Columbia
Sponsor class: OTHER
First posted: 2015-05-14
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Participants will be persons with Type 2 Diabetes who are likely to have increased risk of bone fractures. The investigators believe this medication will enhance bone turnover.

The investigators will use DXA measurements to evaluate bone density before and after subjects take the medication.

Detailed description: Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of bone fractures even when there is not decreased bone density via DXA measurements. This appears primarily related to impaired bone quality and abnormal bone architecture. Although the exact pathophysiologic mechanisms remain unclear, low bone turnover is considered one of the key defects. Emerging evidence suggests that dipeptidyl peptidase (DPP) inhibition is associated with improved bone quality and reduction in fracture risk.

While animal studies have shown an improvement in bone mineral density and trabecular architecture with sitagliptin treatment, no such studies in humans have yet been undertaken. We are proposing to extend these animal studies with a pilot clinical trial that seeks to use serum markers of bone turn-over and calcaneal quantitative ultrasound to evaluate the effect of DPP-4 inhibition on bone metabolism. Our hypothesis is that DPP-4 inhibition with sitagliptin will enhance bone turn over and quality in persons with T2DM.

This project project seeks to examine the impact of six months of therapy on sitagliptin, a DPP-4 inhibitor, on bone metabolism and bone quality in subjects with T2DM. The proposed study is intended to be a pilot investigation for providing preliminary data for submission of a more definitive national grant proposal with a larger patient population, blinded randomized control design and high resolution CT imaging of the lumbar spine.

Eligibility criteria: Inclusion Criteria:

1. Type 2 diabetes mellitus.
2. Hemoglobin A1c \>6.5% and \<10%.
3. Estimated GFR greater than 60 mL per minute per meter squared.
4. Between 18 and 70 years of age.
5. On oral antihyperglycemic agents with stable dose at least for last 2 months.
6. Females: minimum of two years postmenopausal, surgically sterile, or using an acceptable contraceptive regimen (OCP, IUD, double barrier, Depo-Provera or subcutaneous progestin implant) and negative urine pregnancy test at trial start.

Exclusion Criteria:

1. Pregnancy, breast feeding or planning pregnancy during the study period
2. Any medical condition expected to be terminal within one year
3. Active mental illness or other condition which in the opinion of the investigator would prevent informed consent or adherence with study protocol
4. Use of any PPAR agonist within three months prior to enrollment
5. Daily insulin use
6. Vitamin D level \< 20
7. Allergy or intolerance of sitagliptin or other DPP-4 inhibitor
8. Use of DPP-4 inhibitor or GLP-1 analog within three months prior to enrollment
9. Significant alcohol use defined as \>3 standard servings of alcohol per day for men and \>2 for women
10. History of bariatric surgery in the last 3 years or planned bariatric surgery during the study period
11. Receipt of another study drug within 30 days of screening.

Primary outcomes:
measure: Change in Bone Turnover
timeFrame: Six Months
Secondary outcomes:
Other outcomes:
Locations:
city: Columbia
country: United States
facility: University of Missouri-Columbia: Diabetes Center
state: Missouri
Study officials:
affiliation: University of Missouri-Columbia
name: Muhammed T Sarmini, MD
role: PRINCIPAL_INVESTIGATOR
References: