louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06200350: Personalized Recommendation System for Sport Activities
Official title: Personalized Recommendation System of Specific Challenges for Sport Activities: Practical Approach to Football
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Health Behavior
Keywords: Performance
Football
Recommender system
Training
Gamification
Blockchain
NFT
Reward
Lead sponsor: University of Vigo
Sponsor class: OTHER
First posted: 2024-01-11
Enrollment: 47
Sex: ALL
Minimum age (years): 14
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Control group will continue with the conventional training. Experimental group will carry out a tailored training based on the profile of each participant.
Primary purpose: OTHER

Brief summary: The goal of this clinical trial is to test and compare the effects of a tailored algorithm recommendation of sport activities concreted in challenges to improve some critical performance dimensions.

Q1: Improving participant performance is achieved by using personalized sports activity recommendation using an algorithm and tracking compliance using a decentralized application (dApp)? Q2: Are participants satisfied with the performance and simplicity of the dApp used?

Participants will be asked to do specific activities recommended by the developed recommender system. The activities to be carried out will be conditioned by the profile obtained from each participant at the beginning of the intervention. They will consist of reinforcement activities for the dimensions with the lowest scores.

Researchers will compare a experimental group and a control group to see if the dimensions assessed at the beginning of the intervention were improved.


Eligibility criteria: Inclusion Criteria:

* Amateur football players.
* Aged between 14 and 18 years old.
* Without any injury.
* The ones who can attend the assessing sessions and fill in the informed consent form.

Exclusion Criteria:

* Aged different from the indicated above.
* Injured.
* Missing one of the assessing sessions.
* Not performing the proposed training twice, or not registering two or more training sessions.

Primary outcomes:
measure: Score of the system usability at the end of the intervention
timeFrame: At the end of the intervention (8 weeks)
Secondary outcomes:
measure: Squat Jump (SJ)
timeFrame: At baseline and after 8 weeks
measure: Abdominal planck (AP)
timeFrame: At baseline and after 8 weeks
measure: Push ups (PU)
timeFrame: At baseline and after 8 weeks
measure: Cooper Test (GE)
timeFrame: At baseline and after 8 weeks
measure: 15m sprint (SE-15)
timeFrame: At baseline and after 8 weeks
measure: Countermovement Jump (CMJ)
timeFrame: At baseline and after 8 weeks
Other outcomes:
measure: Sociodemographic outcomes
timeFrame: At baseline
Locations:
city: Pontevedra
country: Spain
facility: University of Vigo
Study officials:
References:
Clinical trial NCT00000450: Naltrexone Maintenance Treatment of Alcoholism
Official title: Nalmefene Maintenance Treatment of Alcoholism
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Alcoholism
Lead sponsor: The Scripps Research Institute
Sponsor class: OTHER
Collaborators: name: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
First posted: 1999-11-03
Enrollment: 159
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: Naltrexone 50 mg was provided for 3 months to all study participants, who were masked regarding the identity of study medication. At 3 months, full and partial responders were randomized to an additional 9 months of double blind treatment with naltrexone or matched placebo. Full responders were defined as complete abstinence for the last six weeks of the acute phase. Partial responders were defined as having no more than 2 heavy drinking days in any given week and/or a 50% reduction in weekly alcohol consumption from baseline over the last six weeks of the acute phase.
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the long-term effectiveness of naltrexone treatment in alcohol-dependent patients who respond to short-term treatment. Those who respond to short-term treatment will be randomized to a 1-year, double-blind, placebo-controlled maintenance phase with a 6-month posttreatment followup.


Eligibility criteria: Inclusion Criteria:

* Meets criteria for alcohol dependence.
* Expresses a desire to cut down or stop drinking.

Exclusion Criteria:

* Currently meets criteria for dependence on substances other than alcohol.
* History of opiate dependence or evidence of current opiate use.
* Significant medical disorders that will increase potential risk or interfere with study participation.
* Liver function tests more than 3 times normal or elevated bilirubin.
* Female patients who are pregnant, nursing, or not using a reliable method of birth control.
* Inability to understand and provide a consent form.
* Treatment with an investigational drug during the previous month.
* Prior treatment with naltrexone.
* Chronic treatment with any narcotic-containing medications during the previous month.
* Sensitivity to naltrexone as evidenced by adverse drug experiences especially with narcotic containing analgesics or opioid antagonists.
* Current treatment with disulfiram.
* More than 6 weeks of abstinence.
* Meets criteria for a major psychiatric disorder and is in need of, or currently undergoing pharmacotherapy.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Miami
country: United States
facility: Department of Psychiatry, University of Miami School of Medicine
state: Florida
Study officials:
affiliation: The Scripps Research Institute
name: Barbara Mason, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05736250: Establishment of a Method for Extraction and Quantification of Gingival Tissue Nicotine y
Official title: Establishment of a Method for Extraction and Quantification of Gingival Tissue Nicotine in Relation to Conventional Tobacco Biomarkers: a Pilot Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Smoking, Cigarette
Lead sponsor: University of Liege
Sponsor class: OTHER
First posted: 2023-02-21
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: smoker patients

Brief summary: establishment of a method for extraction and quantification of gingival tissue nicotine in relation to conventional tobacco biomarkers: a pilot study

Detailed description: The study aim to establish a method for extraction and quantification of gingival tissue nicotine. Additionnaly, the relationship between the nicotine tissue intoxication with others smoking indicators will be evaluated as mentionned in the following PICO question:

* P: Smoker patients
* I: Biopsie of gingival tissue
* C: Non-smoker patient
* O: nicotine dependence test (FTND), salivary cotinine, fibroblast nicotine, number of cigarette consumed per day (NCC) and the pack-year (PY)

Eligibility criteria: Inclusion Criteria:

* non smokers
* smokers

Exclusion Criteria:

* not able to have biopsie

Primary outcomes:
measure: nicotine
timeFrame: baseline
measure: nicotine dependance
timeFrame: baseline
Secondary outcomes:
measure: salivary cotinine
timeFrame: baseline
measure: number of cigarette consumed
timeFrame: baseline
measure: pack-year
timeFrame: baseline
Other outcomes:
Locations:
city: Liège
country: Belgium
facility: Salhi
state: Liege
Study officials:
References:
Clinical trial NCT05075850: PatiEnt Neuropsychological outcomeS After laseR Ablation
Official title: PatiEnt Neuropsychological outcomeS After laseR Ablation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cognitive Change
Keywords: Quality of Life
Neuropsychological Test Scores
Visual Field
Lead sponsor: Monteris Medical
Sponsor class: INDUSTRY
First posted: 2021-10-13
Enrollment: 81
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: This study is being conducted as a sub-study within the LAANTERN registry; therefore, all enrolled patients in PENSAR must be consented to both protocols.

Brief summary: PatiEnt Neuropsychological outcomeS After laseR ablation

Detailed description: This is a multicenter sub-study that will include comprehensive neuropsychological assessment data collection done at baseline (within 1 year prior to the index LITT procedure) and at follow-up (at least 6 months from the index LITT procedure). Visual field testing will be conducted in a subset of enrolled patients. Up to 250 subjects may be enrolled at up to 15 study sites.

Eligibility criteria: Inclusion Criteria:

1. Patient or legally authorized representative provides written authorization and/or consent.
2. Patient is enrolled in the LAANTERN trial and had an epilepsy diagnosis without the presence of a malignant brain tumor.
3. Patient is 16 years of age or older.
4. Patient has completed a baseline comprehensive neuropsychological assessment with a neuropsychologist.

Exclusion Criteria:

1. Patient does not complete the index LITT procedure as specified in the LAANTERN registry.

Primary outcomes:
measure: Site-determined Cognitive Changes Per Domain
timeFrame: At least six months from baseline assessment. Subjects were analyzed even if they only had 1 test performed. The baseline test information can still be used even if they didn't have follow up testing done.
Secondary outcomes:
measure: Change in Raw Test Scores From Standard Battery of Preferred Neuropsychological Tests
timeFrame: At least six months from baseline assessment.Subjects were analyzed even if they only had 1 test performed. The baseline test information can still be used even if they didn't have follow up testing done.
Other outcomes:
Locations:
city: Little Rock
country: United States
facility: University of Arkansas for Medical Sciences
state: Arkansas
city: Orlando
country: United States
facility: Advent Health Orlando
state: Florida
city: Kansas City
country: United States
facility: University of Kansas Medical Center
state: Kansas
city: Louisville
country: United States
facility: University of Louisville
state: Kentucky
city: Louisville
country: United States
facility: Norton Healthcare
state: Kentucky
city: Pittsburgh
country: United States
facility: University of Pittsburgh
state: Pennsylvania
city: Dallas
country: United States
facility: University of Texas Southwestern Medical Center
state: Texas
Study officials:
affiliation: University of Kansas
name: Patrick Landazuri, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05948150: The Effect of Breastfeeding Pillow on Breastfeeding Self-Efficacy and Postpartum Comfort in Women Who Had Cesarean
Official title: The Effect Of Breastfeedıng Pıllow On Breastfeedıng Self- Effıcacy And Postnatal Comfort In Prımıparous Postpartum Women Who Gave Bırth By Caesarean Sectıon
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cesarean Section; Dehiscence
First Birth
Keywords: Breastfeeding
Exclusive Breast Milk
Patient Comfort
Self-efficacy
Lead sponsor: Ataturk University
Sponsor class: OTHER
First posted: 2023-07-17
Enrollment: 80
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Quantitative
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The research is a randomised controlled experimental study. It was conducted to examine the effect of breastfeeding pillow on breastfeeding self-efficacy and postnatal comfort in primiparous puerperas who gave birth by caesarean section. The answers to the questions "Is the breastfeeding pillow effective on breastfeeding self-efficacy in primiparous puerperium giving birth by caesarean section?" and "Is the breastfeeding pillow effective on comfort during breastfeeding in primiparous puerperium giving birth by caesarean section?" are investigated. The puerperas in the experimental group were allowed to use a breastfeeding pillow during breastfeeding and evaluated at 24th and 48th hours. Puerperas in the control group continued routine breastfeeding and did not use a breastfeeding pillow. They were evaluated at 24th and 48th hours.


Eligibility criteria: Inclusion Criteria:

* Graduated from primary school
* No communication problems
* The desire to breastfeed your baby,
* The mother and the baby do not have any health condition that may prevent breastfeeding,
* First pregnancy,
* Having given birth at 37\> 37 weeks of gestation,
* Having a baby weighing at least 2500 g,
* Over 18 years of age,
* Caesarean section with a single healthy baby

Exclusion Criteria:

* having given birth more than once
* Under 18 years of age
* communication problems
* unhealthy baby birth

Primary outcomes:
measure: Increasing breastfeeding self-efficacy by using a nursing pillow
timeFrame: 48 hours
measure: Increasing postpartum comfort by using a nursing pillow
timeFrame: 48 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Erzincan
country: Turkey
facility: Erzincan Binali Yıldırım University Mengücek Gazi Training and Research Hospital
Study officials:
affiliation: humeyra.dinc@erzincan.edu.tr
name: İltifat H Dinç
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01833650: The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer
Official title: A Randomized Controlled Trial of the Effectiveness of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Thyroid Cancer
Keywords: thyroid cancer
radioiodine treatment
xerostomia
sialadenitis
Lead sponsor: Cyprus University of Technology
Sponsor class: OTHER
Collaborators: name: Bank of Cyprus Oncology Centre
First posted: 2013-04-17
Enrollment: 120
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine whether the use of honey mouthwashes in the prevention of salivary side effects of 131I (radioiodine) therapy.


Eligibility criteria: Inclusion Criteria:

* \>18 years old
* They had a histological diagnosis of papillary, follicular, medullary or anaplastic thyroid cancer
* They had undergone total thyroidectomy
* They were able to provide consent

Exclusion Criteria:

* patients who had distant metastases,
* a history of salivary-gland disorders,
* collagen tissue disease
* diabetes mellitus,
* previous radioiodine therapy or external radiation to the head or neck
* allergy to the honey

Primary outcomes:
measure: Grade of sialadenitis
timeFrame: Change from Baseline grade of sialadenitis at 6 and 24 months
Secondary outcomes:
measure: Grade of Xerostomia
timeFrame: Change from Baseline grade of xerostomia at 6 and 24 months
measure: Level of Health related quality of life
timeFrame: Change from Baseline level of health related quality of life at 6 and 24 months
Other outcomes:
measure: Salivary Quantity (Quantitative Salivary Scintigraphy)
timeFrame: Change from Baseline quantity of saliva at 6 and 24 months
Locations:
city: Nicosia
country: Cyprus
facility: Bank of Cyprus Oncology
Study officials:
affiliation: Cyprus University of Technology
name: Andreas Charalambous, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06872450: Informational Tool for Smoking Cessation in COPD Patients
Official title: Implementation and Impact Study of an Informational Tool for Smoking Cessation in COPD Patients
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Keywords: informational and motivational tool
Lead sponsor: Hopital Nord Franche-Comte
Sponsor class: OTHER
First posted: 2025-03-12
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: People suffering from chronic obstructive pulmonary disease (COPD) stage 2/3

Brief summary: Chronic obstructive pulmonary disease (COPD) is a lung disease that affects nearly 8% of the adult population and causes 18,000 deaths per year in France. The most frequent cause of this pathology is smoking. COPD patients who stop smoking have a better quality of life, a marked a significant slowdown in disease progression and an increased life expectancy. Investigators propose to carry out a quantitative study among patients smokers suffering from COPD, by setting up a tool in the form of an motivational intervention specific to this population.

Detailed description: implementing a tool in the form of an informational intervention with a specific motivational intervention

Eligibility criteria: Inclusion Criteria:

* People suffering from chronic obstructive pulmonary disease (COPD) stage 2/3
* People treated at HNFC
* Smokers

Exclusion Criteria:

* People with cognitive disorders compromising comprehension and completion of the study

Primary outcomes:
measure: motivational effectiveness
timeFrame: 60 days
measure: motivational effectiveness
timeFrame: 60 days
measure: motivational effectiveness
timeFrame: 60 days
Secondary outcomes:
Other outcomes:
Locations:
city: Trevenans
country: France
facility: Hôpital Nord Franche-comté
Study officials:
References:
Clinical trial NCT04208750: Clinical Investigation of the Vision-R800 Device.
Official title: Clinical Investigation of the Vision-R800 Device. Understanding the Value of High Precision Refractions and Lenses to Optometrists and Patients. Phase 2
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Myopia
Hyperopia
Astigmatism
Presbyopia
Lead sponsor: Indiana University
Sponsor class: OTHER
First posted: 2019-12-23
Enrollment: 119
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: Randomized, bilateral, cross-over dispensing study of a standard and VR800 refraction and associated spectacle lenses.


Eligibility criteria: Inclusion Criteria:

* current adaptated progressive addition lens wearer, if bifocal lens required
* wearable pair of glasses \< 2 years old
* wear glasses at least 6 hours per day

Exclusion Criteria:

* Eye Disease with an impact on visual acuity or binocular vision abnormalities (by self-report)
* Formal training in optometry, vision science or in the eyecare field

Primary outcomes:
measure: Subjective Questionnaire Response
timeFrame: at Visit 5 (final visit), up to 5 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Bloomington
country: United States
facility: Indiana University Clinical Optics Research Lab
state: Indiana
Study officials:
References:
Clinical trial NCT02565550: Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome
Official title: Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Irritable Bowel Syndrome
Keywords: Microbiota Community
FODMAPs
IBS
Lead sponsor: Shandong University
Sponsor class: OTHER
First posted: 2015-10-01
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To determine the efficacy of a low FODMAP diet in IBS patients and whether gut microbiota community is associated with its efficacy.

Detailed description: We seek to determine whether a low FODMAPs diet decreases symptoms in irritable bowel syndrome (IBS)patients and to identify potential microbial factors related to diet efficacy. Pain symptoms, stooling characteristics, breath hydrogen, stool microbiome will be collected and/or documented in IBS patients at baseline and during one week of an low FODMAPs intervention.

Eligibility criteria: Inclusion Criteria:

* the presence of Rome III criteria for IBS ;
* Patients scheduled for colonoscopy examination or having negative screening examinations
* Aged between 18 and 65 years old

Exclusion Criteria:

* Antibiotic, probiotic or laxative usage within 4 weeks.
* organic gastrointestinal diseases
* Severe systematic disease: diabetes mellitus, hepatic, renal or cardiac dysfunction, thyroid disease or tumor etc.
* pregnancy or lactation.
* previous major or complicated abdominal surgery.
* severe endometriosis and dementia

Primary outcomes:
measure: changes of symptom scores
timeFrame: 5 months
Secondary outcomes:
measure: proportion of responders
timeFrame: 3 months
measure: quality of life in IBS patients
timeFrame: 5 months
measure: microbial composition in different response to low FODMAPs
timeFrame: 5 months
Other outcomes:
Locations:
city: Jinan
country: China
facility: Department of Gastroenterology, Qilu Hospital, Shandong University
state: Shandong
Study officials:
affiliation: Qilu Hospital of Shandong University
name: Yanqing Li, MD.PhD
role: PRINCIPAL_INVESTIGATOR
References: