louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00977704: Study of Restylane and Perlane in the Correction of Peri-Oral Wrinkles
Official title: An Open-label Study of the Safety of Restylane and Perlane in the Correction of Peri-oral Wrinkles.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Peri-oral Wrinkles
Keywords: Correction of peri-oral wrinkles
Lead sponsor: Medicis Global Service Corporation
Sponsor class: INDUSTRY
First posted: 2009-09-16
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is an open-label study to assess safety using Restylane and Perlane in the correction of facial wrinkles.


Eligibility criteria: Inclusion Criteria:

* Same Wrinkle Severity (either both Moderate \[3\] or both Severe \[4\]) of marionette lines and upper peri-oral rhytids

Exclusion Criteria:

* Active or chronic skin disease, inflammation or related conditions, near or on the Nasolabial Folds
* Subjects who had undergone procedures based on active dermal response (e.g., laser or chemical peeling procedures) within 6 months prior to study entry
* Use of any facial tissue augmenting therapy with non-permanent filler or aesthetic facial surgical therapy within 9 months prior to study entry
* Permanent implant placed in the Nasolabial Fold area

Primary outcomes:
measure: Local and Systemic Adverse Events
timeFrame: 2-weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Coral Gables
country: United States
facility: Call For Information
state: Florida
city: Dallas
country: United States
facility: Call For Information
state: Texas
Study officials:
affiliation: Medicis Global Services
name: Mary Sanstead, RN, BSN, CCRC
role: STUDY_CHAIR
References:
Clinical trial NCT05001204: 68Ga-NOTA-RM26 PET/CT for the Detection of Gastrointestinal Stromal Tumor
Official title: 68Ga-NOTA-RM26 PET/CT for the Detection of Gastrointestinal Stromal Tumor
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: Gastrointestinal Stromal Tumors
Keywords: PET/CT
RM26
GRPR
gastrin-releasing peptide receptor
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2021-08-11
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluation efficacy of 68Ga-NOTA-RM26 in Gastrointestinal stromal tumor（GIST）patients. A single dose of 55.5 to 148 MBq(1.5-4 mCi) of 68Ga-NOTA-RM26 will be injected intravenously. Patients underwent whole-body PET/CT scans at 30-90 minutes after intravenous injection.

Detailed description: Rm26 is a bioactive polypeptide containing 9 amino acid residues, which can specifically bind to gastrin releasing peptide receptor (GRPR, BB2 receptor). Previous studies have confirmed that there are a large number of GRPR receptors in human common types of tumors, such as lung cancer, breast cancer, prostate cancer, head and neck squamous cell carcinoma, glioma and gastrointestinal tumors. Therefore, the use of various radionuclide labeled gastrin releasing peptide receptor analogues RM26 for tumor targeted imaging and treatment greatly improves the early detection rate of tumor, and has important clinical significance and value in tumor staging, prognosis evaluation and curative effect evaluation.This prospective pilot study investigated the use of 68Ga-NOTA-RM26, an antagonist targeting gastrin-releasing peptide receptor (GRPR), for evaluating breast cancer using positron-emission tomography/computed tomography (PET/CT).

Eligibility criteria: Inclusion Criteria:

* Patients in suspicion of gastrointestinal stromal tumors by CT or ultrasonography,and being able to provide basic information and sign the written informed consent form.

Exclusion Criteria:

* The exclusion criteria included claustrophobia, pregnancy, breastfeeding, kidney or liver failure, inability to fulfill the study, and undergoing any preceding local or systemic therapies that might interfere with GRPR binding.

Primary outcomes:
measure: Standardized uptake value of 68Ga-NOTA-RM26 in gastrointestinal stromal tumor
timeFrame: 1 year
Secondary outcomes:
measure: Adverse events collection
timeFrame: 1 week
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College
state: Beijing
Study officials:
References:
Clinical trial NCT02997904: A Clinical Trial Evaluating the Efficacy of Resultz Lice and Egg Elimination Kit on Pediatric and Adult Subjects
Official title: A Randomized Sham Controlled Double Blinded Single Site Clinical Trial Evaluating the Efficacy of Resultz Lice and Egg Elimination Kit for the Removal of Human Head Lice and Eggs on Pediatric and Adult Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pediculus Capitis
Keywords: lice comb
human head lice infestations
combing solution
Lead sponsor: Piedmont Pharmaceuticals, LLC
Sponsor class: INDUSTRY
Collaborators: name: Lice Solutions Resource Network (LSRN) Research
First posted: 2016-12-20
Enrollment: 100
Sex: ALL
Minimum age (years): 2
Maximum age (years): 90
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: A one day study to demonstrate that Resultz Lice and Egg Elimination Kit is statistically superior to a sham control with one hour of combing.

Detailed description: Resultz Lice and Egg Elimination Kit will be efficacious in the removal of human head lice infestations in children and adult subjects under simulated real world conditions.

Eligibility criteria: Inclusion Criteria:

* Must have active head lice infestations (at least 1 live louse and eggs)
* Good general health based on medical history
* Each subject has to be consented

Exclusion Criteria:

* Subjects with any condition that would compromise the study
* History of irritation or sensitivity to pediculicides or hair care products
* Subjects with cranial or facial implants
* Subjects who have received radiation within the last 6 months
* Subjects with history of heart disease
* Subjects with history of epilepsy or seizure disorders
* Subjects with neuro-stimulator or pacemaker
* Subject with hair that staff cannot comb
* Subject previously treated in study in last 30 days
* Use of lice treatment in past 2 weeks
* Subject unable to sense pain
* Subject unable to communicate pain

Primary outcomes:
measure: The Total Number of Lice + Eggs Removed From the Head After One Hour of Combing
timeFrame: 1 hour
Secondary outcomes:
measure: Total Number of Lice Removed, Total Number of Eggs Removed
timeFrame: 1 hour
Other outcomes:
Locations:
city: West Palm Beach
country: United States
facility: Lice Solution Resource Network Research
state: Florida
Study officials:
affiliation: Lice Solutions Resource Network Research
name: Katie Shepherd
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04564404: Neuromusculaire Monitoring Survey
Official title: Neuromusculaire Monitoring Survey - Financial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Survey, Financial
Lead sponsor: Universitair Ziekenhuis Brussel
Sponsor class: OTHER
First posted: 2020-09-25
Enrollment: 692
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This survey aims to better define the willingness-to-buy for Applications in Neuromuscular Monitoring throughout European hospitals.

Detailed description: This study consists of a simple online survey that takes approximately 2 minutes to complete.

The study aims to assess the willingness-to-buy for Applications in Neuromuscular Monitoring (monitoring and software-based) within the anesthesia departments of European hospitals. The survey is targeted to the department heads of the questioned anesthesia departments.

Eligibility criteria: Inclusion Criteria:

* Active Anesthesiology department heads of European Anesthesiology departments.

Exclusion Criteria:

* None

Primary outcomes:
measure: Willingness to buy questionnaire
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Jette
country: Belgium
facility: UZ Brussel
state: Brussel
Study officials:
References:
Clinical trial NCT06137404: A Comparison of Metacarpophalangeal Joint Blocking Splint With Relative Motion Extension Splint for Trigger Finger
Official title: A Comparison of Metacarpophalangeal Joint Blocking Splint With Relative Motion Extension Splint for Trigger Finger
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Trigger Finger
Lead sponsor: Waikato Hospital
Sponsor class: OTHER
First posted: 2023-11-18
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this research is to evaluate the effectiveness of two splint designs in conservative management of trigger finger.

Detailed description: This study aims to analyse and compare the effectiveness of metacarpophalangeal joint blocking splint versus relative motion extension splint for trigger finger. This will help us find out which one of the two splint designs is more effective in the management of trigger finger, thus improving treatment outcomes for patients with trigger finger.

Eligibility criteria: Inclusion Criteria:

* Trigger finger patient

Exclusion Criteria:

* Diabetes, non-English speaking

Primary outcomes:
measure: Green's classification for trigger finger
timeFrame: 12 weeks
Secondary outcomes:
measure: QuickDASH (Disability of Arm, Shoulder and Hand)
timeFrame: 12 weeks
Other outcomes:
measure: Visual Analogue Scale (VAS)
timeFrame: 12 weeks
Locations:
city: Hamilton
country: New Zealand
facility: Waikato Hospital
state: Waikato
Study officials:
affiliation: Waikato Hospital
name: Aarti Parekh, B.Physio
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06913504: Comparison Of Blue Light Filter Feature and Blue Blocking Lenses in Digital Device Users With Dry Eye Patients
Official title: Comparison Of Blue Light Filter Feature and Blue Blocking Lenses in Digital Device Users With Dry Eye Patients
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Dry Eye Syndromes
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2025-04-06
Enrollment: 54
Sex: FEMALE
Minimum age (years): 12
Maximum age (years): 34
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Comparing Blue Light Filter feature and Blue Blocking Lenses for Dry Eye Patients Prolonged screen time can exacerbate dry eye symptoms.

Detailed description: Two solutions, blue light filter software and blue blocking lenses, aim to reduce eye strain. Blue light filter software adjusts screen color temperatures, reducing blue light emission. Blue blocking lenses provide a physical barrier, blocking blue light from reaching the eyes.

Eligibility criteria: Inclusion Criteria:

* Adults aged 12-34
* Spend at least 4 hours per day on digital devices.
* Experience dry eye symptoms.
* Willing to participate in the study and provide informed consent.

Exclusion Criteria:

* Pre-existing eye conditions (e.g., cataracts, glaucoma).
* Wear contact lenses.
* Have undergone eye surgery.
* Are pregnant or breastfeeding.

Primary outcomes:
measure: The Ocular Surface Disease Index (OSDI)
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Khursheed baigam eye hospital raiwind road manga mandi
state: Punjab
Study officials:
References:
Clinical trial NCT01804504: Nutrition Education on the Metabolic Syndrome of Subjects Who Are Frequently Eating Out
Official title: Survey on Eating Out Behavior and Dietary Structure in Urban Chinese Citizens and the Effect of Nutrition Education
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Metabolic Syndrome
Keywords: Metabolic syndrome
Eating out of home
Nutrition education
Lead sponsor: Second Military Medical University
Sponsor class: OTHER
First posted: 2013-03-05
Enrollment: 78
Sex: ALL
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The project is aimed at investigating the effect of nutrition education on knowledge, attitude and practice (KAP)of subjects who are frequently eating out, and the effect on metabolic parameters.

Detailed description: The project is aimed at investigating the dietary structure and frequencies of eating out via a cross-sectional study, on the basis of which a randomized, parallel controlled trials is to be carried out.The purpose is to evaluate the effect on metabolic parameters.

Hypotheses to be tested:Nutrition education has the effect of improving the metabolic parameters of subjects who are frequently eating out.

Eligibility criteria: Inclusion Criteria:

* Shanghai urban citizens
* Male or female 18 to 25 years of age;
* Frequently eat out(eat out 3 or more times per week);
* Clinical diagnosis of Metabolic Syndrome(Meet 3 or more Diagnostic criteria); A. Abdominal obesity: waist circumference\>90cm ( M ), and\>85cm( F ); B. Dyslipidemia:triglyceride≥1.7mmol/L; C. HDL-C \< 1.04mmol/L; D. hypertension: blood pressure≥ 130/85mm Hg ( or have been diagnosed hypertension); E. Hyperglycemia : FPG≥6.1mmol/L and ( or ) 2-hour postprandial blood glucose≥7.8mmol/L and ( or ) have been diagnosed with diabetes;
* Signed written informed consent ;
* Can attend lectures.

Exclusion Criteria:

* Pregnant woman;
* Temporary resident population;
* Participating in another clinical trial 6 months before randomization.

Primary outcomes:
measure: Change in Body Weight
timeFrame: Baseline and 24 weeks
Secondary outcomes:
measure: Change in Blood pressure
timeFrame: Baseline and 24 weeks
measure: Change in waist circumference, waist hip ratio, waist to height
timeFrame: Baseline and 24 weeks
measure: Change in Waist, abdominal and hip circumference was measured using a plastic tape to the nearest 0.1 cm Change in fasting blood glucose
timeFrame: Baseline and 24 weeks
measure: Change in serum triglyceride, cholesterol, HDL, LDL
timeFrame: Baseline and 24 weeks
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Changhai Hospital,Second Military Medical University
state: Shanghai
Study officials:
affiliation: Shanghai Changhai Hospital ,Second Military Medical University
name: Donglian Cai, Master
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05552404: Postdural Puncture Headache Relief With Aminophylline and SPGB
Official title: Trans-nasal Sphenopalatine Ganglion Block Versus Intravenous Aminophylline Injection for Treatment of Postdural Puncture Headache After Caesarean Section Under Spinal Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Anesthesia
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2022-09-23
Enrollment: 75
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to compare Sphenopalatine ganglion block (SPGB) and aminophylline in the efficacy and safety management of PDPH.

Detailed description: Postdural puncture headache (PDPH) is a severe and debilitating complication after regional anesthesia in the obstetric population; The gold standard treatment for PDPH is epidural blood patch, which is an invasive and risky procedure.

The trans-nasal sphenopalatine ganglion (SPG) block and intravenous aminophylline are promising options for PDPH. So the investigators designed this randomized, double-blind study to compare Sphenopalatine ganglion block (SPGB) and aminophylline in the efficacy and safety management of PDPH.

Eligibility criteria: Inclusion Criteria:

* 18 - 40 years old female.
* ASA I -II according to the American society of anesthesiologists.
* Spinal anesthesia with 22G Quincke needle for cesarean section.
* PDPH was defined according to the international classification of headache disorders, 3rd edition criteria (ICHD-3) as:

  * Headache occurring within 5 days of a lumbar puncture.
  * Orthostatic headache that significantly worsens soon after sitting upright or standing and/or improves after lying horizontally usually accompanied by neck pain, tinnitus, changes in hearing, photophobia, and/or nausea.
  * Exclusion of other causes such as hypertension, preeclampsia, tension headache, migraine, etc.

Exclusion Criteria:

* A history of headaches that could interfere with the PDPH diagnosis,
* A history of central nervous system diseases, including intracranial hemorrhage, seizures, intracranial hypertension, or hydrocephalus
* A history of cardiovascular diseases, including coronary heart disease, arrhythmias, or hypertension.
* A history of allergy to or any contraindication for using Aminophylline.
* Coagulopathy.
* Nasal septal deviation, polyp, or nasal bleeding.
* General anesthesia after failed spinal anesthesia.

Primary outcomes:
measure: the headache severity in the form of Visual Analogue score (VAS) at 12 hours after treatment.
timeFrame: at 12 hours
Secondary outcomes:
measure: Patient Global impression of change (PGIC) scale
timeFrame: at 24 hours
measure: Adverse effects
timeFrame: at 24 hours
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: faculty of medicine, Ain Shams University
Study officials:
affiliation: Faculty of medicine, Ain Shams University, Cairo, Egypt
name: tamer S abdelaziz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05644704: Intelligent Sports Injury Prevention and Training System
Official title: SportSense 6D Fusion - Application of Multi-sensor Fusion Environment in Movement, Training and Injury Prevention in Bat and Arm Swing Sports-Intelligent Sports Injury Prevention and Training System
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Sport Injury
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2022-12-09
Enrollment: 40
Sex: MALE
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Sports injuries are a very important issue for baseball players. Previous studies have found that the incidence of sports injuries faced by baseball players is continuously increasing. Sports injury rates in professional baseball, high school baseball, and college baseball players were as high as 3.6, 4.6, and 5.8 per 1,000 players, respectively. The main cause of many pitching injuries is attributed to a large number of repetitive pitches. To avoid sports injuries, it is necessary to know how to assess the risk of injury caused by repetitive pitching. Throwing is a fairly complex action that requires the coordination of the entire body. It is critical to investigate the biomechanical changes of players in order to effectively analyze such complex movements.


Eligibility criteria: Inclusion Criteria:

* Healthy baseball pitchers
* Age between 18\~55 years old

Exclusion Criteria:

* Surgery history in pitching arm
* Musculoskeletal disease
* Neuromuscular disease

Primary outcomes:
measure: Countermovement jump (CMJ)
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University
Study officials:
References:
Clinical trial NCT00358904: Assessment of Weber Humeral Derotational Osteotomy Using CT Scan
Official title: Assessment of Weber Humeral Derotational Osteotomy Using CT Scan
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hill Sachs
Keywords: Hill Sachs
Weber osteotomy
shoulder dislocation
Lead sponsor: University of British Columbia
Sponsor class: OTHER
First posted: 2006-08-01
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects who have had the Weber osteotomy for Hill-Sachs lesions.

Brief summary: Subjects who have had the Weber osteotomy for Hill-Sachs lesions will have CT of Both shoulders. Amount of rotation in operative shoulder will be compared to contralateral. QOL will be assessed


Eligibility criteria: Inclusion Criteria:

* Subjects who have had the Weber osteotomy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Vancouver
country: Canada
facility: Vancouver General Hospital, Orthopaedics Dept.
state: British Columbia
Study officials:
affiliation: The University of British Columbia
name: William Regan, MD
role: PRINCIPAL_INVESTIGATOR
References: