Clinical trial NCT03662243: Treatment for Reading and Writing Deficits Following Acquired Brain Injury
Official title: Treatment for Reading and Writing Deficits Following Acquired Brain Injury
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acquired Brain Injury
Alexia
Agraphia
Lead sponsor: Quality Living, Inc.
Sponsor class: OTHER
First posted: 2018-09-07
Enrollment: 2
Sex: ALL
Minimum age (years): 14
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: People enrolled in rehabilitation programs at Quality Living in Omaha, Nebraska, who are between the ages of 14 and 70 years and who experience alexia and/or agraphia secondary to acquired brain injury.

Brief summary: Many people with acquired brain injuries have deficits in reading decoding, reading comprehension, and written expression. Alexia is a phenomenon in which a person who previously could read has trouble doing so after having sustained a brain injury; likewise, agraphia is an acquired writing problem affecting one or more aspects of written communication. Alexia and agraphia sometimes co-occur with one another and/or with other language challenges, but they can also occur as isolated phenomena. Methods to treat alexia and agraphia often focus on single intervention techniques that address aspects of reading or writing in isolation-such as matching written and spoken letters or letter sounds, performing choral reading, tracing letters, etc. Existing research suggests that the effectiveness of these techniques is limited. However, when used in combination, such techniques may promote improved reading and written communication skills. As such, the purpose of this research is to determine the extent to which a multicomponent intervention program improves the reading and writing capabilities of people with acquired alexia and/or agraphia.


Eligibility criteria: Inclusion Criteria:

* Survivor of acquired brain injury
* Exhibits alexia and/or agraphia
* Past or current client of Quality Living, Inc., Omaha, Nebraska
* Fluent speaker of English

Exclusion Criteria:

* Vision impairment prohibiting reading of 24-point text
* Auditory comprehension problems precluding understanding of consent/assent information

Primary outcomes:
measure: Change in score on Word Attack subtest of the Woodcock-Johnson III Test of Achievement.
timeFrame: Change from baseline at 8 weeks
measure: Change in score on Passage Comprehension subtest of the Woodcock-Johnson III Test of Achievement.
timeFrame: Change from baseline at 8 weeks
measure: Change in score on Word Reading subtest of the Wide Range Achievement Test 4.
timeFrame: Change from baseline at 8 weeks
measure: Change in score on Spelling subtest of the Wide Range Achievement Test 4.
timeFrame: Change from baseline at 8 weeks
measure: Change in score on Test of Silent Reading Speed and Efficiency.
timeFrame: Change from baseline at 8 weeks
Secondary outcomes:
measure: Sight word decoding accuracy
timeFrame: One time per week for 8 weeks
measure: Oral reading rate of passages
timeFrame: As the first of five tasks of each session for 8 weeks (each session is 1 hour).
measure: Decoding errors during oral reading of passages
timeFrame: As the first of five tasks of each session for 8 weeks (each session is 1 hour).
measure: Oral spelling of words
timeFrame: As the second of five tasks of each session for 8 weeks (each session is 1 hour).
Other outcomes:
Locations:
city: Omaha
country: United States
facility: Quality Living, Inc.
state: Nebraska
Study officials:
affiliation: Quality Living, Inc., Omaha, Nebraska
name: Karen Hux, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: