Clinical trial NCT04142801: Efficacy of the Memory Motivation (MEMO) Web Application Training
Official title: Efficacy of the Memory Motivation (MEMO) Web Application for Cognitive and Behavioral Training in Patients With Neurocognitive Disorders
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neurocognitive Disorders
Keywords: Cognition
motivation
technology
non pharmacological intervention
Lead sponsor: Innovation Alzheimer
Sponsor class: OTHER
Collaborators: name: Alzheimer's Association
name: Centre Hospitalier Universitaire de Nice
name: Université de Nice Sophia Antipolis
First posted: 2019-10-29
Enrollment: 49
Sex: ALL
Minimum age (years): 60
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: regular use of a web application at home to train cognition and behavior
Primary purpose: TREATMENT

Brief summary: Memory, attentional, and behavioural symptoms are the clinical hallmarks of Neurocognitive disorders (NCD) such as Alzheimer's disease and related disorders. The World Health Organisation (WHO) guidelines for risk reduction of cognitive decline and dementia indicate that Cognitive training may be offered to older adults with normal cognition and with mild cognitive impairment to reduce the risk of cognitive decline and/or dementia. The use of Information and Communication Technologies (ICT) in the health domain is progressively expanding. The Alzheimer Innovation Association have developed MeMo (Memory Motivation) a free web application that can be used at home by patients.

The objective of the present study was to assess the effectiveness of employing the MeMo platform on cognitive performance in patients suffering from NCD.

Detailed description: The objective of this study is to evaluate the effectiveness of the MeMo cognitive training exercise platform in patients suffering from neurocognitive disorders. These exercises ,have been developed by the association Innovation Alzheimer and the CoBTeK research team, located with the Nice memory Center at the Institut Claude Pompidou. MeMo can be used freely at home by patients. More specifically, it is a randomized controlled study that aims to compare the evolution of activities cognition and behavior between patients not using these exercises, and patients using these exercises for 12 weeks, 4 sessions per week.

Eligibility criteria: Inclusion Criteria:

* Outpatient consulting the Memory center
* older than 60 years old
* Mini Mental State examination score (MMSE) between 16 and 28 / 30
* met the DSM 5 diagnoses of mild neurocognitive disorders (mild NCD) or major neurocognitive disorders (Major NCD).

Exclusion Criteria:

* Patients not able to read and write French
* presence of a hearing or major visual impairment
* a history of premorbid mental retardation
* had already used the MeMo application
* were presently involved in structured memory training activities.

Primary outcomes:
measure: Change is being assessed with the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
timeFrame: Base line, Week 12
Secondary outcomes:
measure: Change in attention is is being assessed with the DSST
timeFrame: Base line, Week 12
measure: Change in frontal functioning is being assessed with the FAB
timeFrame: Base line, Week 12
measure: Change in behavior is being assessed with the NPI
timeFrame: Base line, Week 12
measure: IA-C
timeFrame: Base line, Week 12
Other outcomes:
Locations:
city: Nice
country: France
facility: CoBtek lab, Institut Claude Pompidou
Study officials:
References:
citation: Robert P, Manera V, Derreumaux A, Ferrandez Y Montesino M, Leone E, Fabre R, Bourgeois J. Efficacy of a Web App for Cognitive Training (MeMo) Regarding Cognitive and Behavioral Performance in People With Neurocognitive Disorders: Randomized Controlled Trial. J Med Internet Res. 2020 Mar 11;22(3):e17167. doi: 10.2196/17167.