louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06497621: Comparing Impression Techniques for Maxillary Complete Denture Retention
Official title: Effect of Two Impression Techniques on Retention of Maxillary Complete Denture in Pakistani Population: A Double-blinded Crossover Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Denture Retention
Patient Satisfaction
Keywords: Crossover
Complete Denture
Retention
Poly-vinyl siloxane
Lead sponsor: Aga Khan University
Sponsor class: OTHER
First posted: 2024-07-12
Enrollment: 35
Sex: ALL
Minimum age (years): 35
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The primary objective of this protocol is to compare retention in maxillary complete dentures using single-versus two-step Poly-vinyl Siloxane (PVS) impressions in edentulous patients at denture delivery. Secondary objectives include assessing patient satisfaction with impression methods and denture satisfaction after a two-month adaptation and comparing post-delivery adjustment visits.


Eligibility criteria: Inclusion Criteria:

* Patients with mild to moderately resorbed maxillary alveolar ridge
* Patients with bimaxillary edentulous arches
* Patients aged between 35 to 85 years willing to participate in the study
* Patients who could be available for follow up visits

Exclusion Criteria:

* Patients with palatal torus or bony exostoses or severe undercuts in the maxillary arch
* Patients with uncontrolled diabetes, osteoporosis, osteomalacia and osteopenia
* Patients with xerostomia
* Patients with mucosa covering the denture bearing area with signs of inflammation, ulceration, or hyperplasia.
* Patients undergoing radiotherapy or chemotherapy or maxillofacial surgery
* Patients suffering from maxillofacial trauma
* Patients with neuromuscular disorders
* Patients with clinical signs and symptoms of temporomandibular joint dysfunction
* Patients with highly resorbed maxillary ridge and/ or flabby ridge
* Patient with hypersensitivity to silicone materials

Primary outcomes:
measure: Retention of maxillary denture using digital force meter
timeFrame: At the delivery appointment for each denture at an average of 2.5 week from the start of denture fabrication and at 8th week (+/- 3 days)
Secondary outcomes:
measure: Patient satisfaction with impression methods via the Burdens in Dental Impression-Making Questionnaire (BiDIM-Q)
timeFrame: At the delivery appointment for each denture at an average of 2.5 week from the start of denture fabrication and at 8th week (+/- 3 days)
measure: Denture satisfaction using the Denture Satisfaction (DS) questionnaire.
timeFrame: At 2 months
Other outcomes:
measure: Number of post-insertion visits for denture adjustment
timeFrame: At the end of adjustment period of each denture at an average of 1-month after denture delivery
Locations:
Study officials:
References:
Clinical trial NCT04884321: Complementary And Alternative Medicine During The COVID-19 Pandemic
Official title: Adults' Attitudes Toward Complementary And Alternative Medicine And Their State Of Using Complementary And Alternative Medicine During The COVID-19 Pandemic
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Complementary Therapies
Keywords: Complementary Therapies
COVID-19
Complementary and Alternative Medicine
Attitude
Lead sponsor: Hasan Kalyoncu University
Sponsor class: OTHER
Collaborators: name: Filiz Polat
name: Aynur Ekren Çakıcı
First posted: 2021-05-12
Enrollment: 3242
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The research population was comprised of Turkish citizens who resided in Turkey and were aged 18-65 years.

Brief summary: Complementary and alternative medicine is frequently used in the treatment of several groups of diseases.

Detailed description: This study aimed to explore the attitudes of adults living in Turkey toward complementary and alternative medicine in the period of the COVID-19 pandemic and identify whether Turkish adults used it during the pandemic.

Eligibility criteria: Inclusion Criteria:

* agree to participate in the study
* not to be a communication problem

Exclusion Criteria:

* be a communication problem

Primary outcomes:
measure: Participant adults' responses to the questions raised about the use of complementary and alternative methods during the COVID-19 pandemic
timeFrame: 2021
measure: Means of scores obtained by participant adults from the holistic complementary and alternative medicine questionnaire (HCAMQ) and its sub-scales
timeFrame: 2021
measure: Complementary and alternative treatment methods used during the COVID-19 pandemic
timeFrame: 2021
measure: Plants consumed during the COVID-19 pandemic
timeFrame: 2021
measure: Symptoms against which complementary and alternative methods are used during the COVID-19 pandemic
timeFrame: 2021
Secondary outcomes:
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Hasan Kalyoncu Ünivrsitesi
state: Lütfen Seç
Study officials:
References:
Clinical trial NCT01934621: Adapting Daily Activity Performance Through Strategy Training
Official title: Closing the Gap: Early Intervention for Cognitive Disability After Stroke
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Strategy Training
Attention Control
Keywords: Stroke
Rehabilitation
Cognition
Disability
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
Collaborators: name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
First posted: 2013-09-04
Enrollment: 128
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Individuals with cognitive impairments after stroke sustain significant disability in their daily tasks, and account for a significant proportion of stroke-related healthcare costs. The proposed study examines a novel intervention, strategy training, that shows promise for helping individuals with stroke-related cognitive impairments reduce disability in daily tasks, which may lead to reductions in healthcare costs. We predict that strategy training will result in significantly greater independence 6 months after stroke compared to an attention control intervention, and that strategy training may reduce cognitive impairments.


Eligibility criteria: Inclusion Criteria:

* primary diagnosis of acute stroke
* admission to acute inpatient rehabilitation
* impairment in higher order cognitive functions (EXIT-14 ≥ 3)

Exclusion Criteria:

* pre-stroke diagnosis of dementia in the medical record
* inability to follow two- step commands 80% of the time
* severe aphasia (BDAE ≤ 1)
* current major depressive, bipolar, or psychotic disorder
* drug or alcohol abuse within 3 months

Primary outcomes:
measure: Change in Independence with Daily Activities
timeFrame: Baseline to Month 6
Secondary outcomes:
measure: Change in Executive Functions
timeFrame: Baseline to Month 6
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: University of Pittsburgh
state: Pennsylvania
Study officials:
affiliation: University of Pittsburgh
name: Elizabeth R Skidmore, PhD, OTR/L
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kringle EA, Terhorst L, Butters MA, Skidmore ER. Clinical Predictors of Engagement in Inpatient Rehabilitation Among Stroke Survivors With Cognitive Deficits: An Exploratory Study. J Int Neuropsychol Soc. 2018 Jul;24(6):572-583. doi: 10.1017/S1355617718000085. Epub 2018 Mar 19.
Clinical trial NCT06566664: Peripheral Neurostimulation for Nerve Block Placement
Official title: Peripheral Neurostimulation for Nerve Block Placement
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Pain Syndrome
Keywords: peripheral nerve block
neurostimulation
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2024-08-22
Enrollment: 82
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Peripheral nerve blocks are routinely used and highly successful for intra-operative anesthesia and post-operative pain management. Nerve blocks are guided using either neurostimulation as a means to localize the right nerve or by ultrasound guidance or combining the 2 methods. The purpose of this study is to assess whether electrical stimulation improves nerve block quality, beyond its simple purpose of nerve localization.

Detailed description: The investigators wish to understand how electrical stimulation can affect local anesthetic disposition when performing a peripheral nerve block.

By studying this subject, the investigators open possibilities for improvement on many levels:

increasing the efficacy of the nerve block allows for a reduced onset time, reduced incidence of incomplete block and prolonged duration of the local anesthetics. This allows for patients to fully benefit from the analgesic properties of the nerve block, allows for a decrease in delays for the operating room readiness, and a decrease in the amount of medication needed for a successful nerve block. This will decrease side effects and risks of the nerve blocks. Overall better post-surgical pain control may decrease risks for developing chronic post-operative pain, a major post-operative complication.

The results of this study will open the door to novel approaches to manage acute post-operative pain.

Eligibility criteria: Inclusion Criteria:

* Undergoing elective upper limb surgery with a planned brachial plexus nerve block

Exclusion Criteria:

* Under 18 years old
* ASA score above III
* Chronic pain condition with daily milligrams of morphine equivalent \> 30
* Poorly controlled psychiatric condition
* Coagulopathy
* Active infection
* Moderate, severe or progressing neuropathy
* COPD/Chronic oxygen user
* Pregnancy
* Incarceration
* Unable to consent

Primary outcomes:
measure: Onset of sensory block
timeFrame: Within 1 hour after the block placement
Secondary outcomes:
measure: Onset of motor block
timeFrame: Within 1 hour after the block placement
measure: Duration of sensory/motor block
timeFrame: 1 day
measure: Time to first analgesic request
timeFrame: Up to 1 year
measure: Patient satisfaction
timeFrame: Up to 1 year
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University Hospital
state: California
Study officials:
References:
Clinical trial NCT07013864: Staphylococcus Haemolyticus in the Neonatal Intensive Care Unit of CHSD in 2023: Analysis and Trends
Official title: Staphylococcus Haemolyticus in the Neonatal Intensive Care Unit of CHSD in 2023: Analysis and Trends
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Staphylococcus Haemolyticus
Staphylococcal Infections
Sepsis
Catheter-Related Infections
Infant, Newborn
Intensive Care Units, Neonatal
Cross Infection
Drug Resistance, Bacterial
Lead sponsor: Centre Hospitalier de Saint-Denis
Sponsor class: OTHER
First posted: 2025-06-10
Enrollment: 28
Sex: ALL
Maximum age (years): 2
Standard ages: CHILD
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The inclusion criteria were all newborns in 2023, hospitalized in the Neonatal and Neonatal Resuscitation department of the Saint-Denis Hospital Centre with at least one isolation of S. haemolyticus in blood cultures or catheter cultures.

Brief summary: This study looks at cases of Staphylococcus haemolyticus infections in newborns hospitalized in the Neonatal Intensive Care Unit (NICU) at the Saint-Denis Hospital in 2023. Researchers reviewed the medical records of 28 infants who had this bacteria found in their blood or catheter cultures. The goal is to understand whether these infections have increased and how they affected the babies' health.


Eligibility criteria: Inclusion Criteria:

* Newborns in 2023
* hospitalized in the Neonatal and Neonatal Resuscitation department of the Saint-Denis
* At least one isolation of S. haemolyticus in blood cultures or catheter cultures

Exclusion Criteria:

- No exclusion criteria

Primary outcomes:
measure: Incidence of Staphylococcus haemolyticus Infections Associated with Central Venous Catheters (CVCs)
timeFrame: January 1, 2023 - December 31, 2023
Secondary outcomes:
Other outcomes:
Locations:
city: Saint-Denis
country: France
facility: France
Study officials:
References:
Clinical trial NCT00043264: Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis
Official title: Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Multiple Sclerosis
Lead sponsor: National Center for Research Resources (NCRR)
Sponsor class: NIH
Collaborators: name: National Multiple Sclerosis Society
First posted: 2002-08-08
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Multiple sclerosis (MS) is an inflammatory, demyelinating disease which affects the central nervous system (CNS). The etiology of MS is unknown, although the immune system appears to play a role. Many different infectious agents have been proposed as potential causes for MS, including Epstein-Barr virus, human herpesvirus 6, and coronaviruses. Recently Dr. Sriram at Vanderbilt University has found evidence for active Chlamydia pneumonia infection in the CNS of MS patients. These findings have been replicated in part by other laboratories.

The purpose of the current study is to test whether antibiotic treatment aimed at eradicating Chlamydia infection will reduce the disease activity in MS. The primary outcome measure will be reduction in new enhancing MS lesions on brain MRI. Forty patients will be entered into the trial. To be eligible, patients must have evidence of chlamydia infection in their spinal fluid and enhancing lesions on their pre-randomization MRI scans. Patients who meet these criteria will be randomized to either placebo or antibiotic therapy, and followed for 6 months on treatment.


Eligibility criteria: Patients with unequivocal diagnosis of multiple sclerosis and have evidence of C. pneumoniae infection in the cerebral spinal fluid

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: University of Texas Medical School
state: Texas
Study officials:
References:
Clinical trial NCT01330264: Study of Intracranial Pressure (ICP) Monitoring in Critically Ill
Official title: Study of ICP Monitoring in Critically Ill
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intracranial Pressure
Keywords: Intracranial Pressure (ICP) Monitoring
Admission to Intensive Care Unit (ICU)
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2011-04-06
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients admitted to the ICU that are receiving Intracranial Pressure (ICP) monitoring.

Brief summary: The SIM City study seeks to explore for the variance in practice that is associated with nursing and medical care of patients with brain pressure (ICP) monitors. The underlying hypothesis is that there is not a consistent pattern of care throughout the U.S., rather, there is a wide range of practice patterns that are used to monitor and treat ICP.


Eligibility criteria: Inclusion Criteria:

* Adult (18 years of age or older)
* Admitted to an Intensive Care Unit (ICU)

Exclusion Criteria:

* Prisoners

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
Study officials:
affiliation: Duke University
name: DaiWai M Olson, PhD RN CCRN
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04190264: Body Cooling in Hyperthermic Males and Females
Official title: Efficacy of the Polar Breeze Thermal Rehabilitation Machine in Cooling Recreationally Active Males and Females Following Exercise-induced Hyperthermia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cryotherapy Effect
Lead sponsor: University of North Carolina, Greensboro
Sponsor class: OTHER
First posted: 2019-12-09
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Participants will complete three trials under three different body cooling conditions/interventions; passive cooling using the body's natural body cooling mechanisms, body cooling using cold water immersion, and cooling using the investigational thermal rehab machine.
Primary purpose: OTHER

Brief summary: Exertional heat stroke (EHS) is an emergency medical condition that is prevalent in military soldiers, athletes, and laborers. It is diagnosed when the rectal temperature is above 40°C with the presence of central nervous dysfunction (altered mental status). The gold standard method of care for EHS is immediate onsite whole body cooling using cold-water immersion (cooling rates \>0.15°C•min-1), which is reported to have the highest cooling rate. In the treatment of EHS, selecting a cooling modality with a high cooling rate becomes crucial to minimize the time above the critical threshold of body temperature at 40°C to less than 30 minutes for the best chance of survival and to minimize the severity of prognosis. However, in situations where cold water immersion is not feasible (in certain military, firefighter, or other remote settings), other cooling modalities must be available that have a cooling capacity similar to that of cold-water immersion. In this proposed study, we aim to compare the cooling rates of the Polar Breeze® (developed by Polar Breeze ®, Clearwater, FL), cold-water immersion (the current gold standard for EHS treatment), and passive cooling in individuals with exercise-induced hyperthermia


Eligibility criteria: Inclusion Criteria:

* males and females between the ages of 18-35.
* recreationally active (regularly exercise at a minimum of 4-5 times per week for greater than 30 minutes per session)

Exclusion Criteria:

* chronic health problems
* fever or current illness at the time of testing
* history of cardiovascular, metabolic, or respiratory disease
* current musculoskeletal injury that limits physical activity
* history of exertional heat illness in the past three years

Primary outcomes:
measure: Change in Internal Body Temperature
timeFrame: 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60 minutes post onset of cooling
Secondary outcomes:
Other outcomes:
Locations:
city: Greensboro
country: United States
facility: University of North Carolina at Greensboro
state: North Carolina
Study officials:
References:
Clinical trial NCT00972764: Laryngomalacia No Longer An Ambiguity
Official title: Laryngomalacia No Longer An Ambiguity
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Laryngomalacia
Keywords: Laryngomalacia
Factors Associated or Predisposing
Lead sponsor: Boushahri Clinic Medical Center
Sponsor class: OTHER
First posted: 2009-09-07
Enrollment: 1500
Sex: ALL
Minimum age (years): 14
Maximum age (years): 2
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Primary care clinics

Brief summary: The purpose of this study is to expose some of the factors that may be associated or predisposing to development of laryngomalacia.

Detailed description: Laryngomalacia is the most common congenital malformation of the larynx and it is a self-limited disorder. It is the most common cause of stridor in newborns and infants. It results from an abnormal prolapse of supraglottic structures during inspiration. Despite its widespread prevalence, the etiology of laryngomalacia is unclear. Most infants will squeaky but otherwise well. Although affected patients do not exhibit much in the way of other physical symptoms, the unusual voice is worrisome to their parents.

Eligibility criteria: Inclusion Criteria:

* Babies delivered with laryngomalacia with ≥ 37 weeks of gestation
* Delivered with birth weights ≥ 2.5 kg
* No history of natal or post-natal complications
* From the same community

Exclusion Criteria:

* Pre-term babies
* History of natal or post-natal complications

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Kuwait
country: Kuwait
facility: Boushahri Clinic Medical Center
state: P.O.Box :698 Salmiya
Study officials:
affiliation: New Children's Hospital, Cairo University
name: Mohamed S EL-Sayed, MBBCh,MSc,MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06401564: Virtual Reality Based Rehabilitation After Ischemic Stroke
Official title: Improving Functional and Cognitive Outcomes After Ischemic Stroke Using Virtual Reality Based Rehabilitation
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Ischemic Stroke
Keywords: virtual reality
stroke rehabilitation
quality of life
upper extremity
Lead sponsor: Stony Brook University
Sponsor class: OTHER
Collaborators: name: Good Samaritan Hospital
First posted: 2024-05-06
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Use the template below as a guide to write a brief study description in plain language. Tailor the text that appears in brackets and yellow to your research study. To finalize, delete the text in italics.

The goal of this single-arm study is to explore the use of early virtual reality-based rehabilitation as an adjunct to conventional physical/occupational therapy in adult patients with acute ischemic stroke. The main question it aims to answer is:

Feasibility and tolerability of using immersive Virtual Reality technology-based therapy for patients suffering from acute ischemic stroke in an inpatient hospital setting Participants will receive 1 or 2 virtual reality therapy sessions and complete surveys at the end of each session.


Eligibility criteria: Inclusion Criteria:

* Age \> 18
* MRI or CT imaging confirmed ischemic stroke
* Able to follow multistep commands

Exclusion Criteria:

* Plegia in both arms
* Previous reported history of vertigo or inner ear dysfunction
* Patients with epilepsy
* Patients who cannot begin therapy during admission
* Patients who are pregnant
* Patients with a pre-existing condition that interferes with virtual reality usage (e.g., visual impairment, limitation of either upper extremity or neck).

Primary outcomes:
measure: Feasibility survey
timeFrame: After each session up to 5 weeks
measure: Simulator sickness questionnaire
timeFrame: After each session up to 5 weeks
Secondary outcomes:
measure: Adverse events
timeFrame: After each session up to 5 weeks
measure: NIHSS
timeFrame: Hospital discharge, an average of 7 days
measure: Modified Rankin Scale (mRS)
timeFrame: Hospital discharge, an average of 7 days
measure: Duration of sessions
timeFrame: After each session up to 1 week
measure: Time spent by therapist
timeFrame: After each session up to 1 week
Other outcomes:
Locations:
city: Stony Brook
country: United States
facility: Stony Brook University Hospital
state: New York
Study officials:
affiliation: Stony Brook University Hospital
name: Jason Mathew, DO
role: PRINCIPAL_INVESTIGATOR
References: