louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01405703: Percutaneous Versus Open Plate Fixation of Diaphyseal Clavicle Fractures
Official title: Percutaneous Versus Open Plate Fixation of Diaphyseal Clavicle Fractures
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Clavicle Fracture
Keywords: Clavicle Fractures
Numbness
Percutaneous plate fixation
open plate fixation
incision related numbness
union rates
subjective
questionnaire based outcomes
Diaphyseal
Lead sponsor: University of Utah
Sponsor class: OTHER
First posted: 2011-07-29
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients treated surgically for diaphysial clavicle fracture.

Brief summary: This is a prospective, level II evidence comparison between two cohorts. This study is designed to compare the percutaneous versus open approach for plate fixation of diaphyseal clavicle fractures. This study includes questionnaires and measurements that will collect data on incision-related numbness, union rates, overall outcomes, complication rates of the two methods, infection rates, and overall satisfaction. The surgical procedure, all radiographs and follow-up visits to a minimum of one year are the principle investigators (PI's) standard of care for this injury. Measurements and questionnaires are related to the study.


Eligibility criteria: Inclusion Criteria:

* 18 years of age or older
* displaced (i.e., no cortical contact of fracture ends on two xray view) diaphyseal clavicle fracture
* fracture pattern amenable to plate fixation
* neurologic injury requiring open reduction
* open clavicle fracture
* clavicle nonunion (defined as an absence of radiographic bony union in the presence of neurologic, cosmetic, or functional complaints at six months duration
* symptomatic malunion (defined as a healed, but shortened or angulated fracture in the presence of neurologic, cosmetic, or functional complaints)
* clavicle fracture associated with a scapular of humeral fracture (floating shoulder)

Exclusion Criteria:

* a nondisplaced or minimally displaced closed, neurovascularly intact clavicle fracture
* fracture of the medial or lateral end of the clavicle
* pathological fracture
* patient is unable to medically tolerate general anesthesia
* patient is unable to provide informed consent or comply with completing questionnaires

Primary outcomes:
measure: Functional outcome as measured by Constant Shoulder Score and Disabilities of the Arm, Shoulder and Hand (DASH) score
timeFrame: 1+ year post-op
Secondary outcomes:
measure: Incision numbness at surgical site.
timeFrame: 2 wks, 6 wks, 3 mths, 6mnths and 1+ year post-op
Other outcomes:
Locations:
city: Salt Lake City
country: United States
facility: University of Utah Orthopedic Center
state: Utah
Study officials:
affiliation: University of Utah
name: Erik Kubiak, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Utah
name: Thomas Christensen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00667303: Prospective Surveillance For Respiratory Virus Infections In Children Undergoing Hematopoietic Stem Cell Transplantation
Official title: Prospective Surveillance For Respiratory Virus Infections In Children Undergoing Hematopoietic Stem Cell Transplantation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Respiratory Virus Infections
Keywords: Hematopoietic stem cell transplant
Lead sponsor: St. Jude Children's Research Hospital
Sponsor class: OTHER
First posted: 2008-04-28
Enrollment: 51
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Children, birth to 18 years old, within the first 100 days of a hematopoietic stem cell transplant who are either asymptomatic, or symptomatic with an upper respiratory tract infection (URTI) or a lower respiratory tract infection (LRTI).

Brief summary: The Study aims to prospectively survey the incidence of respiratory virus infections using molecular methodologies, in children undergoing hematopoietic stem cell transplantation

Detailed description: Samples will be collected with a nasopharyngeal wash and processed for direct fluorescent antibody, culture and Polymerase chain reaction (PCR)

Eligibility criteria: Inclusion Criteria:

* Age: Birth to 18 years.
* Patients undergoing an allogeneic HSCT for any disease.
* Parent or guardian willing to sign informed consent.

Exclusion Criteria:

* Intra nasal lesion which precludes the performance of the nasopharyngeal wash.
* Patients on Continuous Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (BiPAP).

Primary outcomes:
measure: Incidence of RV infection at any time after transplant: The day of onset of an infection is defined as the day when the first positive diagnostic test was performed.
timeFrame: All patients will be followed until day +100 after the HSCT.
Secondary outcomes:
Other outcomes:
Locations:
city: Memphis
country: United States
facility: St. Jude Children's Research Hospital
state: Tennessee
Study officials:
affiliation: St. Jude Children's Research Hospital
name: Ashok Srinivasan, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00736203: Memory and Picture Viewing Study
Official title: Memory and Picture Viewing Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Brain Reactivity of Non-smokers Undergoing fMRI Scanning
Keywords: fMRI
non-smokers
Lead sponsor: Duke University
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2008-08-15
Enrollment: 116
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: generally healthy, right-handed non-smokers, between the ages of 18-55, having smoked less than 50 cigarettes in their lifetime

Brief summary: The purpose of this study is to obtain a database of brain function from a sample of non-smokers while they do tasks in an MRI (magnetic resonance imaging) machine. Our hypothesis is that among nonsmokers, reactivity to smoking cues will be highly similar to control cues but may vary as a function of attitudes toward smoking and/or family history of smoking. We also hypothesize that brain activity during the n-back task will be more similar to data collected during this task when smokers are not abstinent.

Detailed description: Thirty six non-smokers will undergo functional magnetic resonance imaging (fMRI) scanning. During scanning participants will complete the n-back task-a measure of working memory-and the cue-reactivity task-a measure of responses to smoking cues. Before scanning, participants will complete a training session where they will be familiarized with the tasks.

All participants will have to pass a screening visit in order to be included in the study.

Eligibility criteria: Inclusion Criteria:

* generally healthy
* right-handed non-smokers
* between the ages of 18-55
* an expired CO concentration of 5 ppm or less; or a negative urine cotinine test of 100 ng/mL or less (to confirm a non-smoker)
* having smoked \< 50 cigarettes in their lifetime

Exclusion Criteria:

* inability to attend all sessions
* significant health problems (hypertension, emphysema, seizure disorder, history of significant heart problems)
* use of psychoactive medications
* use of any tobacco or nicotine containing products
* current alcohol or drug abuse
* use of illegal drugs as measure by a urine drug screen
* presence of conditions that would make MRI unsafe (pacemaker, metallic implants

Primary outcomes:
measure: brain reactivity
timeFrame: 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
Study officials:
affiliation: Duke University
name: Joseph McClernon, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04833803: Development of the Eating Behaviour Lapse Inventory Survey Singapore (eBLISS):An Exploratory Mixed-method Study
Official title: Development of the Eating Behaviour Lapse Inventory Survey Singapore (eBLISS):An Exploratory Mixed-method Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Eating Behavior
Lead sponsor: National University Health System, Singapore
Sponsor class: OTHER
Collaborators: name: National University of Singapore
First posted: 2021-04-06
Enrollment: 530
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who are overweight or obese and are following up at the Centre for Obesity Management and Surgery (COMS) at the National University Hospital (NUH).

Brief summary: An exploratory mixed-method study will be conducted to develop an instrument for early detection and prevention of overconsumption.


Eligibility criteria: Inclusion Criteria:

1. Above the legal age of 21 years old
2. Have a BMI ≥ 23kg/m2
3. Able to understand and read English language
4. Uses a smart phone that can download apps
5. Able to provide informed consent

Exclusion Criteria:

1. Diagnosed with a pre-existing psychological disorder such as anxiety and depression except binge eating disorder
2. Participating in a concurrent weight management intervention that is beside the usual care

Primary outcomes:
measure: Self-regulation of Eating Behaviour Questionnaire (SREBQ)
timeFrame: 2021-2023
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01642303: The Effect of Vodcasting on Listening Comprehension
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
PHASE3
Conditions: Listen to Vodcast
Keywords: vodcasting,listening,language education
Lead sponsor: Mashhad University of Medical Sciences
Sponsor class: OTHER
First posted: 2012-07-17
Enrollment: 106
Sex: MALE
Minimum age (years): 18
Maximum age (years): 21
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL

Brief summary: Improvement of the internet and its tremendous growth has caused significant progress in transformation of information. Nowadays in any place of the world and in any time of the day by accessing through internet every student can use different kinds of information in World Wide Web which let him to make the best decision what, how and when to study. One of these educational technologies which are beneficial to learners is vodcast or video recording which are accessible through the internet.This paper is going to examine the listening comprehension in EFL learners and whether it may be improved by using vodcasts. So106 language learners of four different classes of Iranian higher intermediate in an English institute were chosen for this study. These learners were pre-tested by IELTS Listening Comprehension. Two classes were chosen as subject group which consisted of 54 learners. The remaining two classes were chosen as control group which consisted of 52 learners. Both groups were taught Listening Impact book, but students in subject group were provided some vodcasts based on the topic of their lessons. After 12 weeks of teaching both groups were post-tested.listening comprehension will be compared using independent t-test and paired t-test.


Eligibility criteria: Inclusion Criteria:

* EFL learner
* upper intermediate level

Exclusion Criteria:

* Other levels

Primary outcomes:
measure: improving listening comprehension
timeFrame: up to 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05249803: "Clinical Characteristics, Comorbidities and Outcome of Critically Sick Patients With COVID-19
Official title: "Clinical Characteristics, Comorbidities and Outcome of Critically Sick Patients With COVID-19 Pneumonia Admitted in Intensive Care Unit of a Tertiary Care Hospital in Lahore, Pakistan": A Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19 Pneumonia
Keywords: Comorbidities
Outcomes
Covid-19
Lead sponsor: FMH College of Medicine and Dentistry
Sponsor class: OTHER
First posted: 2022-02-22
Enrollment: 133
Sex: ALL
Minimum age (years): 16
Maximum age (years): 85
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Non-interventional retrospective cohort study of critically sick patients with COVID-19 pneumonia admitted in the Intensive Care Unit of Fatima Memorial hospital (FMH) in Lahore, Pakistan from March 2021 to August 2021 4.3. Sample Size \& Technique: Records of 133 patients admitted to the ICU of the Fatima memorial hospital, Lahore, were studied.

Brief summary: COVID-19, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), is a multisystem disease which primarily involves the respiratory tract. The first case of COVID-19 was identified in late 2019 in the province of Wuhan, China which was followed by the rapid spread of the disease globally, becoming a present-day pandemic.

Objectives: The aim of this study was to describe the clinical characteristics, comorbidities and outcome of the critically sick patients with COVID-19 pneumonia admitted in ICU of a tertiary care hospital in Lahore.

Detailed description: Objectives: The aim of this study was to describe the clinical characteristics, comorbidities and outcome of the critically sick patients with COVID-19 pneumonia admitted in ICU of a tertiary care hospital in Lahore.

Material \& Methods:

Study design: Retrospective study. Study Settings: Study was conducted in Fatima Memorial Hospital, Lahore. Study Duration: Study was conducted on Covid-19 patients who were admitted from March 2021 to August 2021.

Eligibility criteria: Inclusion Criteria:

* Critically sick patients with COVID-19 Pneumonia
* All admitted ICU patients with a diagnosis of COVID-19 pneumonia
* Patients having positive reverse transcriptase PCR for COVID-19
* Patients with High-resolution computed tomography (HRCT) chest findings suggestive of COVID-related lung injury
* All patients above 16 years of age with both genders( males and females)

Exclusion Criteria:

* All patients with PCR negative with mild symptoms
* Patients with No signs of COVID-19 pneumonia on HRCT chest

Primary outcomes:
measure: Mortality
timeFrame: 6 months
Secondary outcomes:
measure: Comorbidities
timeFrame: 6 months
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Fatima Memorial Hospital College of Medicine & Dentistry
state: Punjab
Study officials:
affiliation: FMH College of Medicine & Dentistry
name: Aijaz Zeeshan K Chachar, MBBS,FCPS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05089903: Breast Cancer Outreach Among Primary Care Patients
Official title: Breast Cancer Outreach Among Primary Care Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Breast Cancer
Keywords: Mammography
Preventive Screening
Population Health
Lead sponsor: Abramson Cancer Center at Penn Medicine
Sponsor class: OTHER
First posted: 2021-10-22
Enrollment: 24680
Sex: FEMALE
Minimum age (years): 40
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: SCREENING

Brief summary: This project aims to evaluate different approaches to increase breast cancer screening among primary care patients at Penn Medicine through a centralized screening outreach program. In a pragmatic trial, the investigators will evaluate different approaches to increase completion of screening among eligible patients, including ordering mammograms in bulk prior to outreach, sending personalized text reminders, and endorsing of the communication by the primary care provider.

Detailed description: While mammograms are recommended by guidelines for early detection of breast cancer, mammogram rates are significantly lower now than they were prior to the initial COVID-19 pandemic surge in early 2020. In this project, the investigators will evaluate different ways of reaching out to eligible patients to encourage them to participate in breast cancer screening. Through letters, texting, and the electronic health record portal (MyPennMedicine (MPM)), the investigators will compare mammogram bulk orders, text messaging, and primary care provider endorsement to traditional outreach messaging with the goal of increasing breast cancer screening uptake.

Eligibility criteria: Inclusion Criteria:

1. Women ages 40-74
2. Followed by Primary Care with a Penn Medicine PCP listed and at least one visit in the last 2 years
3. Health Maintenance due (default biannual screening starting at age 50 or edit modifier based on input by clinician)

Exclusion Criteria:

1. Currently scheduled for a mammogram
2. History of bilateral mastectomy

Primary outcomes:
measure: Mammogram Completion in 3 months
timeFrame: 3 months
Secondary outcomes:
measure: Mammogram Completion in 6 months
timeFrame: 6 months
Other outcomes:
measure: Mammogram Positivity Rate
timeFrame: 3 months
measure: Mammogram Completion by Age Groups
timeFrame: 3 months
measure: Mammogram Completion by Race/Ethnicity
timeFrame: 3 months
measure: Mammogram Completion by Insurance Type
timeFrame: 3 months
measure: Mammogram Completion by Median Household Income by Zip Code
timeFrame: 3 months
measure: Positive Mammograms Resulting in Subsequent Care
timeFrame: 3 months
measure: Mammogram Completion by Electronic Patient Portal Status
timeFrame: 3 months
Locations:
city: Philadelphia
country: United States
facility: Penn Medicine
state: Pennsylvania
Study officials:
affiliation: University of Pennsylvania
name: Shivan Mehta, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03104803: Long-term Paired Associative Stimulation as a Treatment for Incomplete Spinal Cord Injury of Non-traumatic Origin
Official title: Long-term Paired Associative Stimulation as a Treatment for Incomplete Spinal Cord Injury of Non-traumatic Origin
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Spinal Cord Diseases
Spinal Cord Injuries
Lead sponsor: Helsinki University Central Hospital
Sponsor class: OTHER
Collaborators: name: Validia Rehabilitation Center
name: University of Helsinki
First posted: 2017-04-07
Enrollment: 5
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete SCI of non-traumatic origin.


Eligibility criteria: Inclusion Criteria:

* incomplete SCI of non-traumatic origin

Exclusion Criteria:

* epilepsy
* metal inclusion in the head area
* pacemaker
* hearing device
* high intracranial pressure

Primary outcomes:
measure: Daniels and Worthingham's Muscle Testing
timeFrame: 2 days after the last stimulation session
measure: Daniels and Worthingham's Muscle Testing
timeFrame: 1 month after the last stimulation session
Secondary outcomes:
Other outcomes:
Locations:
city: Helsinki
country: Finland
facility: BioMag laboratory
Study officials:
References:
citation: Tolmacheva A, Savolainen S, Kirveskari E, Brandstack N, Makela JP, Shulga A. Paired associative stimulation improves hand function after non-traumatic spinal cord injury: A case series. Clin Neurophysiol Pract. 2019 Aug 13;4:178-183. doi: 10.1016/j.cnp.2019.07.002. eCollection 2019.
Clinical trial NCT02418403: Consumer Engagement to Increase Advance Care Planning: Patient Randomization
Official title: Consumer-directed Financial Incentives to Increase Advance Care Planning Among Medi-Cal Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Advance Care Planning
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
First posted: 2015-04-16
Enrollment: 376
Sex: ALL
Minimum age (years): 65
Maximum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This is a study of the effect of consumer-directed financial incentives on completion of advance care planning among Medi-Cal patients.

Detailed description: Older adults receiving primary care from one of three clinics contracting with Partnership HealthPlan of California, a multi-county Medi-Cal managed care plan will be mass randomized to receiving educational materials regarding advance care planning with or without a financial reward for completing advance care planning.

Eligibility criteria: Inclusion Criteria:

* Partnership HealthPlan of California enrollee
* Receipt of primary care from one of 3 participating clinics (Ole, Petaluma, West County)
* Age \> 65

Exclusion Criteria:

* \> 75

Primary outcomes:
measure: Having an advance care planning conversation with one's primary care provider
timeFrame: 3 months
Secondary outcomes:
measure: Completion of "Prepare for Your Care" website modules
timeFrame: 3 months
Other outcomes:
Locations:
city: Fairfield
country: United States
facility: Partnership HealthPlan of California
state: California
Study officials:
affiliation: University of Pittsburgh
name: Amber Barnato, MD MPH MS
role: PRINCIPAL_INVESTIGATOR
References: