Clinical trial NCT05440890: Early Treatment Based Neuroscience Education in Knee
Official title: Early Treatment Based Neuroscience Education in Anterior Cruciate Ligament Repair Patients
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Anterior Cruciate Ligament Rupture
Anterior Cruciate Ligament Injuries
Keywords: cross-education
physiotherapy
unilateral strength training
fMRI
anterior cruciate ligament
Lead sponsor: University of Malaga
Sponsor class: OTHER
First posted: 2022-07-01
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled trial, with two parallel groups (control and intervention)
Primary purpose: TREATMENT

Brief summary: Determine the effecttiveness of a cross-education strength training protocol in a group of subjects with an anterior cruciate ligament surgery.

Detailed description: The cross-education (CE) phenomenon has been studied in recent years as a form of gain muscle strength not only in healthy subjects but also in acute injuries such as musculoskeletal disorders and immovilitations. Unilateral training of the not injured limb has been suggested as an option to produce cross-edutation in terms of strength and skills. In addition, functional magnetic resonance imaging have been postulated as a promising tool to study the mechanisms of transfer.

In the context of our study, arthrogenic muscle inhibition (AMI) of knee extensors is a common consequence after ACL repair in which a CE strength training can lead to reduce quadriceps atrophy and its implications in long terms achievements. Thus, an unilateral strength protocol of the uninjuried limb, according to the last Delphi Consensus, will be run for 8 weeks to check the possible benefits of the transfer in a sample of ACL repair.

Eligibility criteria: Inclusion Criteria:

* People between 18 and 40 years whith MRI diagnosis of ACL rupture.
* Autograft, allograft or artificail graft of any source.
* With/without any meniscal resection/repair.

Exclusion Criteria:

* Diagnosis of systematic disease, no injury or symptomatic in contralateral lower limb, pregnancy, current or prior neurologic condiction.

Primary outcomes:
measure: Changes in quadriceps strength.
timeFrame: Baseline and 12 weeks post-surgery
measure: Changes in cortical adaptation.
timeFrame: Baseline and 10 weeks post-surgery
Secondary outcomes:
measure: Limb symmetry index (LSI).
timeFrame: Pre- surgery, 12 weeks post-surgery
measure: Peak rate of force development (RFD).
timeFrame: Pre- surgery, 12 weeks post-surgery
measure: Muscle activation.
timeFrame: Pre- surgery, 12 weeks post-surgery
measure: Cross-sectional area of quadriceps
timeFrame: Pre- surgery, 12 weeks post-surgery
measure: The International Knee Documentation Committee (IKDC) questionnarie.
timeFrame: 12 weeks post-surgery
measure: The Lysholm questionnaire.
timeFrame: 12 weeks post-surgery
measure: The Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire.
timeFrame: 12 weeks post-surgery
measure: Muscle thickness of quadriceps.
timeFrame: Pre- surgery, 12 weeks post-surgery
measure: Step length during gait
timeFrame: 12 weeks post-surgery
measure: Contact time with the ground during gait
timeFrame: 12 weeks post-surgery
measure: Cadence of the gait
timeFrame: 12 weeks post-surgery
Other outcomes:
Locations:
Study officials:
References:
citation: Manca A, Hortobagyi T, Carroll TJ, Enoka RM, Farthing JP, Gandevia SC, Kidgell DJ, Taylor JL, Deriu F. Contralateral Effects of Unilateral Strength and Skill Training: Modified Delphi Consensus to Establish Key Aspects of Cross-Education. Sports Med. 2021 Jan;51(1):11-20. doi: 10.1007/s40279-020-01377-7.
citation: Cuyul-Vasquez I, Alvarez E, Riquelme A, Zimmermann R, Araya-Quintanilla F. Effectiveness of Unilateral Training of the Uninjured Limb on Muscle Strength and Knee Function of Patients With Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis of Cross-Education. J Sport Rehabil. 2022 Mar 12;31(5):605-616. doi: 10.1123/jsr.2021-0204. Print 2022 Jul 1.