Clinical trial NCT06606184: Benefits of Pulmonary Rehabilitation to Patients Post Liver Transplant
Official title: Benefits of Pulmonary Rehabilitation to Patients Post Liver Transplant
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Liver Transplant Surgery
Keywords: liver transplant
pulmonary rehabilitation
inspiratory muscle training
inspiratory muscle strength
Dyspnea
Lead sponsor: Chang Gung University
Sponsor class: OTHER
Collaborators: name: Chang Gung University of Science and Technology
name: Chang Gung Memorial Hospital
First posted: 2024-09-20
Enrollment: 78
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial was to access the benefits of a 12-week home-based pulmonary rehabilitation regimen on pulmonary function recovery in post-liver transplant patients. The main questions it aims to answer are:

Does pulmonary rehabilitation facilitate pulmonary muscle strength recovery? Does the intervention improve pulmonary function and reduce dyspnea sensation?

Participants performed:

Inspiratory muscle training twice a day for 12 weeks after discharged from the hospital Upper limb resistive training Lower limb exercise

Detailed description: Patients undergoing liver transplantation often face significant challenges related to pulmonary rehabilitation. Although postoperative rehabilitation has been extensively studied, the specific role of pulmonary rehabilitation programs has received limited attention. This study aims to evaluate the efficacy of a home-based pulmonary rehabilitation program in improving respiratory function recovery among post-liver transplant patients. The training group participated in a 12-week pulmonary rehabilitation program post-discharge, emphasizing respiratory muscle and exercise training, while the control group received standard care, which included traditional rehabilitation.

Eligibility criteria: Inclusion Criteria:

* Age 20 years or older
* Scheduled to undergo living donor liver transplantation
* Stable vital signs
* Normal cognitive function
* Able to perform activities independently using their own strength and coordination
* Willing and able to participate in 12 weeks of rehabilitation training

Exclusion Criteria:

* Severe physical illness during the operation
* Acute bleeding
* Unstable vital signs
* Hepatic encephalopathy, or neurological conditions such as stroke, Parkinson\&#39;s disease, or cognitive dysfunction
* Limited mobility (e.g., unable to stand, lift upper limbs, or bedridden)
* Inability to comply with 12 weeks of pulmonary rehabilitation post-discharge
* Unstable vital signs
* Hepatoencephalopathy, such as cardiovascular accident, Parkinson disease, cognitive dysfunction
* Those with limited mobility (unable to stand, unable to lift upper limbs, or bedridden)
* Those who are unable to cooperate with the 12 weeks of pulmonary rehabilitation exercises after discharge.

Primary outcomes:
measure: Respiratory Muscle Stregnth Test
timeFrame: Throughout the study completion, approximately 3 month
Secondary outcomes:
measure: Oxygenation status
timeFrame: Participants underwent maximum inspiratory and expiratory pressure measurements at four time points: upon admission, before discharge from the intensive care unit, before discharge from the hospital, and at the end of the 12-week enrollment period.
measure: Dyspnea Severity Assessment
timeFrame: Throughout the study completion, approximately 3 month
measure: Forced Vital Capacity
timeFrame: Throughout the study completion, approximately 3 month
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital
Study officials:
affiliation: Chang Gung University of Science and Technology
name: Jui-Fang Lin, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Au KP, Chan SC, Chok KS, Sharr WW, Dai WC, Sin SL, Wong TC, Lo CM. Clinical factors affecting rejection rates in liver transplantation. Hepatobiliary Pancreat Dis Int. 2015 Aug;14(4):367-73. doi: 10.1016/s1499-3872(15)60391-5.
citation: Aamir,T., Iftikhar,S., Khan, R.R., &amp;Khan, M.K (2019).Role of physiotherapy in improving quality Of life in liver transpant patients. The Rehabilitation Journal, 3(2),126-130.