louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03147638: Multi-Center Single Arm Trial to Determine The Effectiveness of Warfarin Therapy Duration For Heparin-Induced Thrombocytopenia (HIT)
Official title: Multi-Center Single Arm Trial to Determine The Effectiveness of Warfarin Therapy Duration For Heparin-Induced Thrombocytopenia (HIT)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Heparin-induced Thrombocytopenia
Lead sponsor: Marshall University
Sponsor class: OTHER
First posted: 2017-05-10
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 97
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Intervention model description: Single arm with retrospective arm The retrospective arm is he comparator and they are historic control
Primary purpose: TREATMENT

Brief summary: Multi-Center Single Arm Trial to Determine The Effectiveness of Warfarin Therapy Duration For Heparin-Induced Thrombocytopenia (HIT)


Eligibility criteria: Inclusion criteria:

* Patient must be able to provide an informed consent
* Patient older than 18 years' old
* Patient with suspected diagnosis of HIT, need 2 of the following:

have a fall in platelet count of \> 30% from a baseline prior to heparin/LMWH Platelet factor 4 (PF4) ELISA positive Develop skin lesions secondary to subcutaneous heparin With T score more than 4 For those less than 4 we will use serotonin release assay-SRA

* Patient received the bridging therapy of non-heparin anticoagulant
* Patient is receiving the standard of care treatment for HIT
* Patient is willing to be followed up for by one of the physicians listed in the delegation log
* The Primary physician responsible for the patient is agreeing for the patient to participate
* Patients are not involved in a clinical trial for HIT management

Exclusion Criteria:

* Patient is unable to sign an informed consent
* Patient doesn't have a confirmed diagnosis of HIT
* Patient Does not have Pulmonary embolus
* Patient does is not on Warfarin for other indications
* Patient is a known case of hypercoagulable disorder
* Patient is not willing to come back for follow up
* Patient is critically ill or has a life expectancy of less than 3 months
* Pregnancy that is in First trimester.
* Multi-system organ failure or estimated survival of less than 30 days
* Uncontrolled hypertension defined as a blood pressure \>180/110 mm Hg

Primary outcomes:
measure: All cause hospitalization
timeFrame: Within six months after treatment
measure: side effects of Warfarin treatment
timeFrame: Within six months after treatment
measure: All cause mortality
timeFrame: Within six months after treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Huntington
country: United States
facility: Marshall University
state: West Virginia
Study officials:
References:
Clinical trial NCT01039779: Tai Chi Exercise in Older People
Official title: A Randomized Trial of Tai Chi Exercise on Reducing Falls in Older Taiwanese People
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Fallers Aged 60 Years and Older
Keywords: older fallers
tai chi
Lead sponsor: Taipei Medical University
Sponsor class: OTHER
Collaborators: name: National Health Research Institutes, Taiwan
First posted: 2009-12-25
Enrollment: 456
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The effects of tai chi exercise and lower-extremity training on improving the primary outcome and secondary outcomes among older people will be compared.

Detailed description: Does not desire.

Eligibility criteria: Inclusion Criteria:

* Persons aged 60 years and older and who require medical attention in the emergency rooms due to sustaining a fall.

Exclusion Criteria:

* A major unstable cardiopulmonary disease
* Cognitive impairment
* Contraindications to physical exercise
* The inability to ambulate
* Frail elderly.

Primary outcomes:
measure: To ascertain the occurrence of falls
timeFrame: 18 months
Secondary outcomes:
measure: Fall-related outcomes of physical and psychological functions will assessed using direct interviews or performance tests at the subject's residence
timeFrame: 18 months
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University
Study officials:
affiliation: Taipei Medical University
name: Mau-Roung Lin, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02030379: Developing an Online Clinical Trial Specific Question Prompt List
Official title: Developing an Online Clinical Trial Specific Question Prompt List
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Cancer
Keywords: Cancer
Lead sponsor: Virginia Commonwealth University
Sponsor class: OTHER
First posted: 2014-01-08
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The investigators will leverage e-technologies to provide an online version of the Question Prompt LIst (QPL-CT), that patients access via available iPads, enabling both the real-time prioritizing of patient questions as well as the seamless delivery of these questions to their treating physician (and other members of their clinical team) via the VCU Health System (VCUHS) patient portal, and the electronic medical record (EMR) prior to a consultation to discuss a clinical trial

Detailed description: The investigators propose to conduct pilot work to inform our knowledge of optimal methods of utilizing QPLs and will use the QPL-CT as an example. The investigators will leverage e-technologies to provide an online version of the QPL-CT, that patients access via available iPads, enabling both the real-time prioritizing of patient questions as well as the seamless delivery of these questions to their treating physician (and other members of their clinical team) via the VCU Health System (VCUHS) patient portal, and the EMR prior to a consultation to discuss a clinical trial. The investigators will use a pilot randomized clinical trial design to demonstrate the efficacy of the online QPL-CT versus a paper and pencil QPL-CT to increase question asking, patient understanding of trial information and reduce patients conflict over their upcoming decision to join a trial

Eligibility criteria: Inclusion Criteria:

* Cancer diagnosis
* Fluent in English
* eligible for a therapeutic clinical trial
* Patients of recruited oncologists

Exclusion Criteria:

* Healthy subjects
* Not eligible for a therapeutic clinical trial

Primary outcomes:
measure: Online QPL-CT to Oncologist
timeFrame: 30 days
Secondary outcomes:
measure: Impact of providing physicians patient's QPL-CT
timeFrame: 30 days
Other outcomes:
measure: Test the feasibility of using the online QPL-CT for patients and physicians
timeFrame: 30 days
Locations:
city: Richmond
country: United States
facility: Virginia Commonwealth University
state: Virginia
Study officials:
affiliation: Virginia Commonwealth University
name: Richard Brown, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02233179: The Association Between Unprotected Standing, Walking and Wound Healing in Diabetes
Official title: Body-worn Sensor Technology for Improving Diabetic Care During Activities of Daily Living
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetic Foot
Keywords: Diabetic foot ulcer
Lead sponsor: University of Arizona
Sponsor class: OTHER
Collaborators: name: Qatar National Research Foundation, Qatar
First posted: 2014-09-08
Enrollment: 49
Sex: ALL
Minimum age (years): 37
Maximum age (years): 68
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study was to explore the association between activities of daily living ( measured using a body-worn sensor) on wound healing in diabetic patients. Since this was an exploratory study, there was no study hypothesis.

Detailed description: Diabetes patients with active foot ulcers were recruited and monitored for activities of daily living while wearing an offloading device.

Eligibility criteria: Inclusion Criteria:

* age 18 or older with non-infected, non-ischemic foot ulcers
* active neuropathic foot ulcer

Exclusion Criteria:

* major foot amputation
* active Charcot arthropathy
* ankle brachial index of 0.5 or less
* history of substance abuse within 6 months
* inability to walk 20m

Primary outcomes:
measure: Wound size
timeFrame: 12 weeks
measure: Daily Physical Activities
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Tucson
country: United States
facility: University Medical Center
state: Arizona
Study officials:
affiliation: University of Arizona
name: David G Armstrong, DPM, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04617379: Stretching and Musculoskeletal Pain
Official title: Stretching Exercises and Musculoskeletal Pain Among Employees Working in the Echocardiographic, Ultrasound and Interventional Laboratories
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Musculoskeletal Pain
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2020-11-05
Enrollment: 190
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of this study is to assess whether a daily, 15-minute stretching routine for one year reduces musculoskeletal pain and improves quality of life in personnel working in the radiology and cardiology departments at Mayo Clinics and Mayo Clinic Health System sites.


Eligibility criteria: Inclusion Criteria:

* A 15-minute daily stretching program will be implemented for 1 year.
* Personnel working in the departments of Cardiology and Radiology at Mayo Rochester, - Mayo Scottsdale, and Mayo Jacksonville and Mayo Clinic Health System.
* Willing to complete standardized questionnaires (DASH, ODI) to assess work-related pain at baseline and at 1 year.
* Employees who respond to questionnaires at baseline and 1 year but don't participate in the stretching exercises will be controls for the study.
* Willing and able to provide written, informed consent.

Exclusion Criteria:

* Pregnancy.
* Inability to participate in the stretching exercises for any reason.
* Preexisting musculoskeletal problems that has required employees to seek active medical or orthopedic treatment.

Primary outcomes:
measure: Change in the DASH index score
timeFrame: 12 months
measure: Change in ODI (Oswestry Disability Index)
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Scottsdale
country: United States
facility: Mayo Clinic Arizona
state: Arizona
city: Jacksonville
country: United States
facility: Mayo Clinic Florida
state: Florida
city: Mankato
country: United States
facility: Mayo Clinic Health System in Mankato
state: Minnesota
city: Rochester
country: United States
facility: Mayo Clinic Rochester
state: Minnesota
city: Eau Claire
country: United States
facility: Mayo Clinic Health System - Eau Claire
state: Wisconsin
city: La Crosse
country: United States
facility: Mayo Clinic Health System - Franciscan Healthcare
state: Wisconsin
Study officials:
affiliation: Mayo Clinic
name: Mandeep Singh, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05585879: Demonstrating Effective Salvage of Inadequate Colonoscopies
Official title: Outpatient Colonoscopy: Demonstrating Effective Salvage of Inadequate Colonoscopies Utilizing the Pure-Vu EVS System
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Colorectal Screening
Lead sponsor: Motus GI Medical Technologies Ltd
Sponsor class: INDUSTRY
First posted: 2022-10-19
Enrollment: 16
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Multicenter, Prospective, Consecutive Series, Pragmatic Clinical Trial
Primary purpose: OTHER

Brief summary: The aim of this study is to demonstrate that the use of the Pure-Vu EVS System can salvage inadequately prepared optical colonoscopies (OCs) to adequate OCs.

Detailed description: The primary objective of this study is to demonstrate the reduction of inadequate colonoscopies when Pure-Vu EVS System is used to salvage inadequately prepped colons as defined by the multi-society guidelines (USMSTF).

Eligibility criteria: Inclusion Criteria:

1. Eligible adults aged between 40-80
2. Elective outpatient colonoscopy by participating gastroenterologist

Exclusion Criteria:

1. Not competent to consent
2. Known or suspected bleeding disorders such as, but not limited to hemophilia and von Willebrand disease
3. History of colonic resection
4. Prior incomplete colonoscopy due to patient anatomy
5. Diverticulitis
6. Active Inflammatory bowel disease (Crohn's, Ulcerative Colitis, or Indeterminate)
7. Known or suspected colon stricture
8. Hereditary Colorectal Cancer Syndrome
9. Subject is pregnant or suspected pregnant

Primary outcomes:
measure: Rate of incomplete colonoscopies
timeFrame: Day 0 (Procedure Day)
Secondary outcomes:
measure: Assessment of Screening
timeFrame: Day 0 (Procedure Day)
measure: Assessment of Screening
timeFrame: Day 0 (Procedure Day)
measure: Procedural Outcome
timeFrame: Day 0 (Procedure Day)
measure: Procedural Outcome
timeFrame: Day 0 (Procedure Day)
measure: Assessment screening
timeFrame: Day 0 (Procedure Day)
measure: Assessment screening
timeFrame: Day 0 (Procedure Day)
measure: Assessment screening
timeFrame: Day 0 (Procedure Day)
measure: Assessment screening
timeFrame: Day 0 (Procedure Day)
measure: Assessment screening
timeFrame: Day 0 (Procedure Day)
measure: Assessment screening
timeFrame: Day 0 (Procedure Day)
measure: Assessment Screening
timeFrame: Day 0 (Procedure Day)
measure: Procedural Outcomes
timeFrame: Day 0 (Procedure Day)
measure: Procedural Outcomes
timeFrame: Day 0 (Procedure Day)
Other outcomes:
measure: User Satisfaction
timeFrame: Day 0(Procedure Day)
measure: Comparison Rates
timeFrame: Day 0 (Procedure Day) - 1-14 day follow up
measure: Economic Impact
timeFrame: Through study completion, an average of 1 year.
Locations:
city: New York
country: United States
facility: NYU
state: New York
Study officials:
affiliation: Motus GI Medical Technologies Ltd
name: Mark Pomeranz
role: STUDY_DIRECTOR
References:
Clinical trial NCT00544479: No Routine CXR After Bronchoscopy
Official title: Is Routine Chest-X-Ray Necessary After Bronchoscpy With Thransbronchial Biopsie? A Prospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pneumothorax
Lead sponsor: Shaare Zedek Medical Center
Sponsor class: OTHER
First posted: 2007-10-16
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All consecutive patients with bronchoscopy and transbronchial biopsies will be enrolled in this study.

Brief summary: Most pulmonologist request a routine chest-x-ray after bronchoscopy with transbronchial biopasie to exclude pneumothorax. We published a study in CHEST showing that routine chest-ray might not be necessary. We would like to conduct a propsective study to validate the results of the CHEST-study. Before and after the procedure follwing information will be collected: Age, Sex, Indication for procedure, number of biopsies and segment of biopsie, Saturation, Physical examination, Symptoms suggestive of pneumothorax. If there is no aggravation of the symptoms and/or physical examination after the procedure, as compared to before, routine chest-x-ray will NOT be done. A phone will be made 24 to 48 hours following the procedure to the patient.


Eligibility criteria: Inclusion Criteria:

* All patients with bronchoscopy and transbronchial biopsie

Exclusion Criteria:

* No informed consent given

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Institue of Pulmonology, Shaare Zedek M.C.
Study officials:
affiliation: Shaare Zedel Medical Center
name: Gabriel Izbicki, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Izbicki G, Shitrit D, Yarmolovsky A, Bendayan D, Miller G, Fink G, Mazar A, Kramer MR. Is routine chest radiography after transbronchial biopsy necessary?: A prospective study of 350 cases. Chest. 2006 Jun;129(6):1561-4. doi: 10.1378/chest.129.6.1561.
Clinical trial NCT03527979: Effect of Laparoscopic Ovarian Drilling on Outcomes of in Vitro Fertilisation in Clomiphene-resistant Women With Polycystic Ovary Syndrome
Official title: Effect of Laparoscopic Ovarian Drilling on the Outcomes of in Vitro Fertilisation in Clomiphene-resistant Women With Polycystic Ovary Syndrome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: PCOS
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2018-05-17
Enrollment: 88
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: the polycystic ovarian syndrome is associated with an ovulation and infertility. recently the laparoscopic ovarian drilling has been used as surgical treatment for ovulation in women with polycystic ovarian syndrome, although its mechanism and outcomes are still unclear. this study is undertaken to evaluate the in vitro fertilisation outcomes in clomiphene-resistant women with PCOS who were treated with LOD.


Eligibility criteria: Inclusion Criteria:

* age between 25 and 35
* patients with established PCOS
* history at least one year infertility
* no response to clomiphene citrate for at least three cycles

Exclusion Criteria:

* history of previous IVF/ICSI
* chronic disease such as thyroid disorder and DM
* infertility due to sever male factor
* sever endometriosis
* infertility due to uterine factor such as multiple fibroid
* body mass index \> 30

Primary outcomes:
measure: clinical pregnancy rate confirmed by b-hcg and visualizations of gestational sac by ultrasound
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams university
Study officials:
References:
Clinical trial NCT02883179: Pain Relief During Repair of Postpartum Perineal Tears
Official title: Topical Lidocaine-prilocaine Cream Versus Lidocaine Infiltration for Pain Relief During Repair of Postpartum Perineal Tears: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Improving Quality of Life
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2016-08-30
Enrollment: 144
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of our study is to compare the analgesic effect of topical application of lidocaine-prilocaine cream and lidocaine infiltration during repair of postpartum perineal tears.


Eligibility criteria: Inclusion Criteria:

1. Gestational age \> 37 weeks
2. Uncomplicated pregnancy
3. Single vertex fetus
4. Normal vaginal delivery
5. Women who will accept to participate in the study

Exclusion Criteria:

1. Women received epidural analgesia
2. Women required episiotomy
3. Women with intact perineum
4. Operative vaginal delivery
5. Allergy to the used drugs

Primary outcomes:
measure: Mean pain score during suture of perineal tears
timeFrame: 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Ahmed Abbas
state: Cairo
Study officials:
References:
Clinical trial NCT03977779: Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis
Official title: Prospective Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Obstructive Jaundice
Biliary Stricture
Sphincter of Oddi Dysfunction
Keywords: biodegradable stent
Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis
Lead sponsor: Institut Paoli-Calmettes
Sponsor class: OTHER
First posted: 2019-06-06
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The use of an endoprothesis in a pancreatic duct is a measure to minimize the incidence and severity of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis. In this study we will evaluate the use of a Biodegradable Endoprothesis: Archimede Fast Biodegradable Pancreatic Stent in patients with high risk of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis.The ARCHIMEDES Fast biodegradable pancreatic stent will be placed during the Endoscopic Retrograde CholoangioPancreatography. The efficacy and the security of the device will be evaluated.


Eligibility criteria: Inclusion Criteria:

* Age\>18 years
* Patients at risk of developing a Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis (procedure and/or patient-related risk factors

Exclusion Criteria:

* Pregnant or breastfeeding women
* Recent diagnosis (\<1 month) of acute pancreatitis
* contraindication to endoscopy
* Hypersensitivity to indomethacine

Primary outcomes:
measure: Percentage of patients with a complete clearance of the biodegradable stent
timeFrame: Day 15
Secondary outcomes:
Other outcomes:
Locations:
city: Marseille
country: France
facility: Institut Paoli Calmettes
state: Provence-Alpes-Côte d'Azur
Study officials:
References:
Clinical trial NCT00166179: Magnetic Resonance Imaging (MRI) Viability: Comparison of Myocardial Viability by Positron Emission Tomography and MRI
Official title: Magnetic Resonance Imaging (MRI) Viability: Comparison of Myocardial Viability by Positron Emission Tomography and MRI
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
Keywords: CAD
Lead sponsor: Emory University
Sponsor class: OTHER
First posted: 2005-09-14
Enrollment: 57
Sex: ALL
Minimum age (years): 18
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Age \> 25 yrs, mean + SD = 60.3 + 10.2, 83% male, are patients referred by cardiologist or cardiac surgeon for assessment of myocardial viability by PET FDG.

Brief summary: The purpose of this study is to compare cardiac MRI with positron emission tomography (PET) with fluorodeoxyglucose (FDG) to determine if cardiac MRI images are as good as, or better, than PET with FDG.


Eligibility criteria: Inclusion Criteria:

* PET-FDG ordered to assess myocardial viability

Exclusion Criteria:

* Contraindicated for MRI
* Pregnant
* Age \<25 yrs

Primary outcomes:
measure: Magnetic Resonance Imaging (MRI) Viability: Comparison of Myocardial Viability by Positron Emission Tomography and MRI
timeFrame: time of initial scans
Secondary outcomes:
measure: Compare size of regions of viable and non viable myocardium as % left ventricle by MRI vs. PET
timeFrame: at time of initial scans
Other outcomes:
Locations:
city: Atlanta
country: United States
facility: Crawford Long Hospital
state: Georgia
Study officials:
affiliation: Staff
name: Randolph Patterson, MD
role: PRINCIPAL_INVESTIGATOR
References: