Clinical trial NCT05971368: A Comparative Study Between Ultrasound Guided Thoracic Paravertebral Block VS Serrartus Anterior Muscle Block in VATS as Regard Their Effectiveness in Post-operative Analgesia
Official title: A Comparative Study Between Ultrasound Guided Thoracic Paravertebral Block VS Ultrasound Guided Serrartus Anterior Muscle Block in Video-assisted Thoracoscopic Surgeries.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Post Operative Pain, Acute
Keywords: regional anesthesia
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2023-08-02
Enrollment: 80
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A comparative study between ultrasound guided thoracic paravertebral block VS ultrasound guided serrartus anterior muscle block in video-assisted thoracoscopic surgeries as regard their effectiveness in post-operative analgesia

Detailed description: The use of loco-regional analgesia is recommended to control postoperative pain after VATS as it allows opioid sparing and facilitates early postoperative rehabilitation. Different loco-regional analgesic techniques could be used to control pain after thoracic surgery such as a paravertebral block, an intercostal block and serratus plane block. In this study, Thoracic paravertebral nerve block will be compared to Serratus anterior nerve block, both will be done Ultrasound guided (USG) using bupivacaine (0.25%) for postoperative analgesia.

Eligibility criteria: Inclusion Criteria:

* Patients American Society of Anesthesiologists physical status (ASA) I to II
* Both sexes.
* Aged ≥ 20 to ≤ 65years.
* Scheduled for VATS under general anesthesia.

Exclusion Criteria:

* Patient's refusal.
* Patients American Society of Anesthesiologists physical status (ASA) III to IV
* Patients with major spine deformities.
* Disruption of the local anatomy, secondary, for instance, to the presence of chest drains or surgical emphysema, resulting in difficulty in ultrasound interpretation and distortion of tissue planes.
* Patients with bleeding disorders and coagulopathy.
* Infection at the injection site.
* Known allergy to local anesthetics.
* Patients with pre-existing myopathy or neuropathy.
* Ipsilateral diaphragmatic paresis.
* Tumors in the paravertebral space at the level of injection.

Primary outcomes:
measure: total amount of opioid consumption in the two groups according to change in VAS score
timeFrame: the first 24 hours postoperatively
measure: visual analog scale (VAS)
timeFrame: the first 24 hours postoperatively
Secondary outcomes:
measure: The onset of 1st analgesic request
timeFrame: The first 24 hours postoperatively
measure: mean arterial blood pressure of the patients
timeFrame: first 24 hours postoperatively
measure: onset of ambulation
timeFrame: first 24 hours postoperatively
measure: complication of nerve block
timeFrame: first 24 hours postoperatively
measure: heart rate of the patients
timeFrame: first 24 hours postoperatively
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of medicine Ain shams university
state: Abbasia
Study officials:
References: