louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06522802: The Effect of Wearing a Mask for Balance and Reaction Time
Official title: Does Wearing a Mask Affect Balance and Reaction Time?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Reaction Time
Balance
Lead sponsor: Istanbul Medipol University Hospital
Sponsor class: OTHER
First posted: 2024-07-26
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: A mask is a protective equipment that covers the mouth and nose and is routinely used in workplaces, public transport and other communal settings preventing harmful particles, dust, droplets, bacteria, viruses, fog, gas, smoke and steam from entering the respiratory system. However, wearing a mask may impair the visual field, potentially affecting balance and reaction time. The investigators' aim is to determine whether the use of masks affects people's balance and reactions.


Eligibility criteria: Inclusion Criteria:

* To be healthy

Exclusion Criteria:

* present or previous balance disorder

Primary outcomes:
measure: Functional reach test
timeFrame: baseline-5 hours later
Secondary outcomes:
measure: COP displacement
timeFrame: baseline-5 hours later
measure: BlazePod evaluation
timeFrame: baseline-5 hours later
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Medipol University
state: Beykoz
Study officials:
References:
Clinical trial NCT03632902: Airway Management With Supraglottic Devices in Unruptured Intracranial Aneurysms
Official title: Airway Management With Supraglottic Devices in Unruptured Intracranial Aneurysm Endovascular Therapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Airway Management
Keywords: supraglottic devices
Lead sponsor: Fundacion Clinic per a la Recerca Biomédica
Sponsor class: OTHER
First posted: 2018-08-16
Enrollment: 205
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who underwent endovascular treatment for unruptured aneurysm in the past 8 years in our institution

Brief summary: Endovascular techniques for the treatment of intracranial aneurysms are growing.

Detailed description: Retrospective analysis of the investigators experience in the last 8 years with the airway management in endovascular therapy for unruptured aneurysms. A total of 206 participants will be included from 2010 to 2018. Airway management (anticipated difficult airway, need for LM repositioning, orotracheal intubation because of failed laryngeal mask insertion, airway complication), intraoperative monitoring, aneurism size and location, intraoperative and perioperative complications will be registered.

Statistics will be compared between groups with t test or x test, as appropriate.

Eligibility criteria: Inclusion Criteria:

* patients that underwent endovascular treatment for unruptured aneurysm

Exclusion Criteria:

* ruptured aneurysm

Primary outcomes:
measure: Security in the use of supraglottic devices in the unruptured intracranial aneurysms.
timeFrame: ten years
Secondary outcomes:
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Hospital Clinic
state: Cataluña
Study officials:
affiliation: anesthesiologist in Hospital Clinic
name: PAOLA A HURTADO RESTREPO, md
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04494802: The Influence of LMA Cuff Pressure on Gastric Insufflation Assessed by Ultrasound in Pediatric Patient
Official title: The Influence of LMA Cuff Pressure on Oropharyngeal Leak Pressure and Gastric Insufflation Assessed by Ultrasound in Pediatric Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Aspiration
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2020-07-31
Enrollment: 230
Sex: ALL
Minimum age (years): 1
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Cuff inflation up to the maximum cuff pressure when using LMA flexible can cause sore throat and discomfort after the surgery, and if the surgery is unexpectedly prolonged, there can be a side effect that can cause ischemic damage around the neck. If keeping cuff pressure low will not increase gastric insufflation and there is no change in other outcome variables, keeping it low may have a positive effect on anesthesia management and outcome in children.


Eligibility criteria: Inclusion Criteria:

* pediatric patients undergoing general anesthesia with LMA flexible

Exclusion Criteria:

* Unstable vital sign, significant arrhythmia or hypotension, Shock
* anticipated difficult intubation or the patient who have facial deformity
* high risk of aspiration
* recent upper respiratory tract infection history

Primary outcomes:
measure: Incidence of gastric insufflation(antrum)
timeFrame: During the surgery(up to 3 hours)
Secondary outcomes:
measure: The size of gastric antrum and body
timeFrame: During the surgery(up to 3 hours)
measure: Time for insertion of LMA flexible
timeFrame: During the anesthesia induction(up to 1 hour)
measure: Success rate of insertion of LMA flexible
timeFrame: During the anesthesia induction(up to 1 hour)
measure: The number of insertion attempt
timeFrame: During the anesthesia induction(up to 1 hour)
measure: The number and the type of additional manipulation for successful ventilation
timeFrame: During the surgery(up to 3 hours)
measure: Ease of insertion of LMA flexible
timeFrame: During the anesthesia induction(up to 1 hour)
measure: Incidence of gastric insufflation(body)
timeFrame: During the surgery(up to 3 hours)
measure: Incidence of gastric insufflation recognized with the ausculation
timeFrame: During the surgery(up to 3 hours)
measure: peak pressure observed before, during, after surgery
timeFrame: During the surgery(up to 3 hours)
measure: oropharyngeal leak pressure
timeFrame: During the surgery(up to 3 hours)
measure: the complication rate
timeFrame: During the surgery and after surgery (up to 6 hours)
Other outcomes:
Locations:
Study officials:
affiliation: Seoul National University Hospital
name: Jin-Tae Kim, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00850902: Humidity Strategy to Decrease Morbidity and Mortality in Extremely Low Birth Weight Infants
Official title: Application of a Different Incubator Humidity Strategy at Birth to Decrease Morbidity and Mortality in Extremely Low Birth (1000 g or Less) Infants
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Extremely Low Birth Weight
Keywords: ELBW
Humidity
BPD
Lead sponsor: King Fahad Medical City
Sponsor class: OTHER_GOV
First posted: 2009-02-25
Enrollment: 700
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to apply a different incubator humidity strategy at birth to decrease morbidity and mortality in extremely low birth (1000 g or less) infants.


Eligibility criteria: Inclusion Criteria:

* Inborn Premature Infants with weight ≤ 1000 g at birth

Exclusion Criteria:

* Outborn infants.
* Failure to obtain parental consent for the study.
* Congenital malformations likely to affect life expectancy or neurosensory development.
* Unlikely to be available for follow up.

Primary outcomes:
measure: Death prior to discharge or Bronchopulmonary Dysplasia (BPD) defined as oxygen requirement at 36 weeks postmenstrual age.
timeFrame: 36 weeks postmenstrual age
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: King Fahad Medical City
name: Jasim Anabrees
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04318821: Effect of Laser Acupuncture on Adhesive Small Bowel Obstruction
Official title: Effect of Laser Acupuncture on Adhesive Small Bowel Obstruction: a Prospective Double-blind Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Adhesive Small Bowel Obstruction
Keywords: Adhesive small bowel obstruction
Laser acupuncture
Acupuncture
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2020-03-24
Enrollment: 92
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Adhesive small bowel obstruction (ASBO) is one of the most common complications and is a major cause of admission after intra-abdominal surgery. To date, the ideal management of ASBO remains controversial. The aim of this protocol designed as a double-blind randomized controlled trial is to investigate the efficacy of laser acupuncture (LA) therapy in patients with ASBO.


Eligibility criteria: Inclusion Criteria:

* Aged 20 to 80 years
* Clinical symptoms and signs of mechanical obstruction

Exclusion Criteria:

* Clear non-adhesive etiology of small bowel obstruction (e.g. tumor, hernia)
* Emergency surgical intervention before being admitted to the hospital
* Pregnancy
* Local skin infection on the acupoints, and limb amputees.

Primary outcomes:
measure: Success rate of conservative treatment
timeFrame: 2 week
Secondary outcomes:
measure: Time to oral intake
timeFrame: 2 weeks
measure: Length of hospital stay
timeFrame: Through study completion, an average of 1 year
measure: Serum lipase
timeFrame: Up to 2 weeks
measure: Serum amylase
timeFrame: Up to 2 weeks
measure: Serum cortisol
timeFrame: Up to 2 weeks
measure: Serum motilin
timeFrame: Up to 2 weeks
measure: Serum ghrelin
timeFrame: Up to 2 weeks
measure: Serum intestinal fatty acid binding protein (I-FABP)
timeFrame: Up to 2 weeks
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital
Study officials:
affiliation: Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital
name: Chun-Ting Liu, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Shih CH, Hsieh TM, Wu BY, Liu CT. Effect of laser acupuncture on adhesive small bowel obstruction: A prospective double-blind randomized controlled trial. Medicine (Baltimore). 2021 Mar 5;100(9):e25035. doi: 10.1097/MD.0000000000025035.
Clinical trial NCT00182221: Safety of a Diagnostic Strategy With D-Dimer Testing for PE
Official title: A Cohort Study Evaluating the Safety of a Diagnostic Strategy Involving D-Dimer Testing in Patients With Suspected Pulmonary Embolism
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Venous Thromboembolism
Keywords: Pulmonary Embolism
Deep Vein Thrombosis
MDA D-Dimer Testing
Diagnostic Algorithm
Lead sponsor: McMaster University
Sponsor class: OTHER
Collaborators: name: Heart and Stroke Foundation of Ontario
First posted: 2005-09-16
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: To determine whether D-Dimer testing, using the MDA D-Dimer assay, can be used to simplify the diagnostic process for pulmonary embolism (PE). This will be assessed by performing a cohort study in 1000 patients with suspected PE.

To ascertain if an MDA D-Dimer result of less than 0.75 ug/mL FEU obviates the need for further testing and therapy in patients with suspected PE.

Detailed description: Prospective cohort study of 1000 patients in which those with a negative D-Dimer result undergo no further testing and are followed for 3 months for venous thromboembolism. Patients with a positive D-Dimer undergo standardized testing.

Eligibility criteria: Inclusion Criteria:

* Age 18 years or older
* Suspected PE

Exclusion Criteria:

* Treatment with full-dose anticoagulants for 24 hours or more OR an ongoing requirement for anticoagulants
* Other tests for PE performed prior to eligibility assessment (e.g.other D-Dimer, V/Q scan, pulmonary angiogram, spiral CT, compression ultrasound, venogram).
* Cardiorespiratory instability requiring immediate performance of other tests to diagnose or exclude PE (i.e. inability to wait 30-60 minutes for MDA D-Dimer result)
* Comorbid condition limiting survival to less than three months
* Patient has been asymptomatic for seven days prior to presentation
* Current pregnancy
* Contraindication to contrast (e.g., allergy, renal failure).
* Geographic in accessibility which precludes follow-up
* Presence of central venous catheter (permanent or temporary, including PICC line) at the time of eligibility assessment

Primary outcomes:
measure: Venousthromboembolism
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Hamilton
country: Canada
facility: St Joseph's Health Care Centre
state: Ontario
city: Hamilton
country: Canada
facility: Hamilton Health Sciences-Henderson Campus
state: Ontario
city: Hamilton
country: Canada
facility: Hamilton Health Sciences-McMaster Campus
state: Ontario
city: Hamilton
country: Canada
facility: Hamilton Health Sciences, General
state: Ontario
Study officials:
affiliation: Hamilton Health Sciences Corporation
name: Shannon M Bates, MDCM,MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05521321: Feasibility and Acceptability of the Cannabis Awareness and Prevention Toolkit
Official title: Feasibility and Acceptability of the Cannabis Awareness and Prevention Toolkit
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cannabis Use
Keywords: youth
cannabis
education
health
prevention
marijuana
Lead sponsor: Stanford University
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2022-08-30
Enrollment: 443
Sex: ALL
Minimum age (years): 10
Maximum age (years): 20
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The Stanford Tobacco Prevention Toolkit is a free, online Toolkit that consists of a curriculum, educational resources, and a resource directory to be used by educators, parents, juvenile justice workers, and healthcare providers to increase knowledge and awareness of cannabis and reduce use among youth. The aim of this study is to investigate the extent to which the curriculum changes students' intentions to use and actual use of cannabis.


Eligibility criteria: Inclusion Criteria:

* Middle school and high school students receiving health education at schools participating in the study

Exclusion Criteria:

-

Primary outcomes:
measure: Change in cannabis use
timeFrame: Change from baseline to follow-up at approximately 156 weeks
measure: Change in intention to use cannabis in the future
timeFrame: Change from baseline to follow-up at approximately 156 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Stanford University
state: California
Study officials:
affiliation: Stanford University
name: Bonnie Halpern-Felsher, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00407121: Intravitreal Bevacizumab for Inflammatory Neovascular Membranes
Official title: Intravitreal Bevacizumab for the Treatment of Neovascular Membranes in Patients With Intraocular Inflammation
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE3
Conditions: Vogt Koyanagi Harada Disease
Serpiginous Choroiditis
Multifocal Choroiditis
Keywords: Neovascular Membrane
Uveitis
Bevacizumab
Lead sponsor: Asociación para Evitar la Ceguera en México
Sponsor class: OTHER
First posted: 2006-12-04
Enrollment: 0
Sex: ALL
Minimum age (years): 25
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Intravitreal injection of Bevacizumab in patients with Neovascular Membranes secondary to intraocular inflammation. We injected a single injection of Bevacizumab (2.5 mg/0.1 ml) and evaluate visual acuity , Fluorescein angiogram and retinal thickness by Optical Coherence Tomography (OCT) in 4 patients with Vogt Koyanagi Harada disease, 1 patient with Serpiginous Choroidopathy and 1 patient with Multifocal Choroiditis.


Eligibility criteria: Inclusion Criteria:

* Clinical Diagnose
* Patient Consent
* Chronic stage of inflammation

Exclusion Criteria:

* only eye
* age lower than 30 yo.
* Systemic condition

Primary outcomes:
measure: Best corrected visual acuity
measure: Retinal thickness by OCT
measure: Leakage in Fluorescein angiogram
Secondary outcomes:
Other outcomes:
Locations:
city: Mexico
country: Mexico
facility: Asociacion para Evitar la Ceguera en Mexico
state: Distrito Federal
Study officials:
affiliation: Asociación para Evitar la Ceguera en México
name: Veronica Kon-Jara, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Asociación para Evitar la Ceguera en México
name: LuzElena Concha-Del Rio, MD
role: STUDY_CHAIR
References:
Clinical trial NCT05786521: Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults
Official title: The Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Biomarkers of Aging in Older Overweight/Obese Adults With Insulin Resistance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Aging
Diabetes Mellitus, Type 2
PreDiabetes
Overweight and Obesity
Lead sponsor: The University of Texas Health Science Center at San Antonio
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2023-03-27
Enrollment: 20
Sex: ALL
Minimum age (years): 65
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Semaglutide is a medication approved by the US Food and Drug Administration (FDA) as an antihyperglycemic (a drug that reduces glucoses in those with diabetes) and for weight management. This new study will help find out what effects, semaglutide has on people who take the drug and the drug's effect on physical function, body composition, and aging.


Eligibility criteria: Inclusion Criteria:

* Older than 65
* Have prediabetes or diabetes
* BMI ≥ 27.0 kg/m2
* Living independently (not in assisted living or nursing home)

Exclusion Criteria:

* Have heart disease
* Have liver disease
* Smoke

Primary outcomes:
measure: Lean Body Mass Change
timeFrame: Baseline to 20 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: San Antonio
country: United States
facility: UT Health San Antonio
state: Texas
Study officials:
affiliation: UT Health San Antonio
name: Tiffany M Cortes, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05846321: Registry for Vascular Trauma and Follow-up Examinations
Official title: Registry for Vascular Trauma and Follow-up Examinations
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Vascular Injury
Keywords: Trauma
Vascular trauma
Bleeding
Ischemia
Registry
Lead sponsor: University Hospital Augsburg
Sponsor class: OTHER
First posted: 2023-05-06
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients treated at university hospital Augsburg for trauma

Brief summary: Within the framework of the project presented here, a registry for traumatic vascular injuries will be established at Augsburg University Hospital. Patients who are treated at our hospital for an isolated vascular trauma or a vascular involvement in (poly-)trauma will be included. This is a rare complication of trauma, so data collection in a registry is useful to pool data on therapeutic procedures and outcome.

These patients differ from the usual vascular surgery patient clientele because there is usually no previous vascular disease. Healthy vessels show different physiological responses than pre-diseased vessels. The usual therapeutic procedures and materials are also developed for arteriosclerotic or aneurysmatic vessels. Therefore, a core objective of this study is to assess long-term outcomes after vascular trauma.


Eligibility criteria: Inclusion Criteria:

* Age over 18 years
* Vascular involvement in trauma
* Isolated vascular injury
* Written informed consent, except for those deceased from trauma sequelae

Exclusion Criteria:

* Minority
* Lack of consent

Primary outcomes:
measure: Long term follow-up after vascular injury
timeFrame: Assessments will be performed at different time points. In the first year after trauma at 3 time points: 3, 6 and 12 months. Through study completion, an average of 1 year
Secondary outcomes:
measure: Reintervention rate
timeFrame: Assessments will be performed at different time points. In the first year after trauma at 3 time points: 3, 6 and 12 months. Through study completion, an average of 1 year
measure: Development of treatment patterns
timeFrame: Assessments will be performed at different time points. In the first year after trauma at 3 time points: 3, 6 and 12 months. Through study completion, an average of 1 year
Other outcomes:
Locations:
city: Augsburg
country: Germany
facility: University Hospital Augsburg
Study officials:
References:
Clinical trial NCT04506021: A Real World Study on Clinical Efficacy of Bicarbonate Ringer's Solution in Biliary Atresia Children
Official title: A Multicenter Real World Study on Clinical Efficacy of Sodium Bicarbonate Ringer's Solution in Children With Biliary Atresia
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Biliary Atresia
Keywords: Biliary Atresia
Bicarbonate Ringer's solution
Perioperative fluid management
Lead sponsor: Tongji Hospital
Sponsor class: OTHER
First posted: 2020-08-10
Enrollment: 110
Sex: ALL
Maximum age (years): 90
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study Population was diagnosed with biliary atresia, who need Intravenous infusion.

Brief summary: In most babies with biliary atresia (BA) bile ducts on the inside and outside of the liver are affected eventually leading to a complete blockage of bile flow from the liver. This in turn causes scarring (fibrosis) in the liver. The surgery called the Kasai procedure and eventually, a liver transplant could treat biliary atresia. However, children with BA have poor liver function, poor renal reserve, and poor ability to regulate water and electrolytes. Therefore, A reasonable and effective perioperative fluid management is more significant. Considering the high chlorine of saline, the liver burden of Lactated Ringer's solution and Acetated Ringer's solution, the Bicarbonate Ringer's solution which composition is similar to plasma, could be the best choice for perioperative fluid management of BA children. Therefore, we hypothesize that compared with other crystalloids, Bicarbonate Ringer's solution is a better choice to maintain water, electrolyte and acid-base balance in BA children.


Eligibility criteria: Inclusion Criteria:

1. patients diagnosed with biliary atresia before surgery.
2. age less than 90 days.
3. American Society of Anesthesiologists score of 1\~2.

Exclusion Criteria:

1. patients with severe allergies.
2. patients with severe deformities or lesions.
3. other situations not suitable for enrollment judged by researchers.

Primary outcomes:
measure: Arterial blood gas changes
timeFrame: 1 day
measure: Intraoperative dosage of sodium bicarbonate injection
timeFrame: 1 day
measure: Chlorine concentration
timeFrame: 3 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Tongji hospital of huazhong university of science and technology
name: Jiexiong Feng
role: PRINCIPAL_INVESTIGATOR
References: