louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06572579: A Pilot Registry for Ultrasound-guided Pharmacopuncture
Official title: Safety and Effectiveness of Ultrasound-guided Pharmacopuncture for Spinal Diseases: A Pilot Registry
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Neck Pain
Back Pain
Lead sponsor: Jaseng Medical Foundation
Sponsor class: OTHER
First posted: 2024-08-27
Enrollment: 50
Sex: ALL
Minimum age (years): 19
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed with spinal disorders who have undergone ultrasound-guided pharmacopuncture treatment

Brief summary: A pilot study of prospective resigstry to evaluate the safety and efficacy of ultrasound-guided pharmacopuncture for spinal disorders

Detailed description: This study aims to evaluate the safety and efficacy of ultrasound-guided pharmacopuncture by collecting information on adverse reactions, efficacy assessment variables, and treatment methods from patients diagnosed with spinal disorders who have undergone ultrasound-guided pharmacopuncture treatment.

Eligibility criteria: Inclusion Criteria:

1. Individuals diagnosed with spinal disorders (M code and S code based on KCD criteria)
2. Outpatients scheduled for ultrasound-guided pharmacopuncture treatment
3. Individuals aged 19 years or older and under 70 years
4. Individuals who agree to participate in the clinical study and voluntarily sign the consent form

Exclusion Criteria:

1. Individuals who are unable to complete the consent form
2. Individuals who are deemed unsuitable for participation in the clinical study by the researcher

Primary outcomes:
measure: Adverse Event
timeFrame: Treatment visits up to 12 weeks, and Week 2, 4, 8, 12 follow-ups
Secondary outcomes:
measure: Spinal pain numeric rating scale
timeFrame: Week 0, Treatment visits up to 12 weeks, and Week 2, 4, 8, 12 follow-ups
measure: Disability index
timeFrame: Week 0, 2, 4, 8, 12
measure: EQ-5D-5L
timeFrame: Week 0, 2, 4, 8, 12
measure: Patient satisfaction
timeFrame: Week 4
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Jaseng Hospital of Korean medicine
state: Gangnam-Gu
city: Bucheon
country: Korea, Republic of
facility: Bucheon Jaseng Hospital of Korean Medicine
state: Gyeonggi Province
city: Daejeon
country: Korea, Republic of
facility: Daejeon Jaseng Hospital of Korean medicine
state: Seo-gu
Study officials:
affiliation: Jaseng Medical Foundation
name: In-Hyuk Ha, Dr
role: STUDY_DIRECTOR
References:
Clinical trial NCT04918979: Information Extraction and Database Construction for Emergent Patients Based on Voice and Image Recognition Technology
Official title: Triage Information Extraction Technology Development and Database Construction for Emergent Patients Based on Voice and Image Recognition Technology
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Emergencies
Keywords: Triage
Emergency department
Voice recognition
Image recognition
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: National Research Foundation of Korea
First posted: 2021-06-09
Enrollment: 428
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults who visit the emergency department without one of the exclusion criteria will be enrolled in this study.

Brief summary: Video and audio data of the triage process of emergency department (ED) patients will be collected to build a database. Clinical information retrieved from the database with voice and image technology will be used to determine the triage level of each patient and will be compared with the actual triage level.

Detailed description: Study Objectives:

1. To develop a platform to record video and audio data of the ED triage process.
2. To retrieve clinical information using voice and image technology.
3. To develop a tool to determine ED triage level using voice and image technology.
4. To build a clinical database using video and audio data using voice and image technology.

Study design: Single center observational study (tertiary hospital emergency department in Korea).

A platform to record video and audio data of the ED triage process will be developed. The camera and microphone will be installed at an optimal location to retrieve video and audio data in the ED triage area.

Voice and image technology will be used to retrieve clinical information including demographic information, chief complaint, type and onset of symptoms, past medical history, and physical examination results to build a database. Clinical information including examination notes, diagnosis, patient vital signs, test results, and ED results will be retrieved from the hospital database.

Eligibility criteria: Inclusion Criteria:

* Age 19 years or older
* Visited the emergency department of the study hospital

Exclusion Criteria:

* Patients who do not agree to enroll to this study
* Without a family
* Foreign patients

Primary outcomes:
measure: The degree of agreement between emergency department triage level retrieved using voice/image technology and by nurses/physicians.
timeFrame: At the time of study completion (May 2022 anticipated).
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Ki Jeong Hong, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT02775279: Association Between Telomere Length and Risk of Acute Coronary Syndrome
Official title: Short Telomere Length in Peripheral Blood Leukocyte Predicts the Risk of Acute Coronary Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Coronary Syndrome
Keywords: acute coronary syndrome, telomere length, predictive factor
Lead sponsor: Air Force Military Medical University, China
Sponsor class: OTHER
First posted: 2016-05-17
Enrollment: 400
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: A total of 200 eligible ACS patients were anticipated to include in this study.Moreover, The 200 healthy controls without previous CHD history were also recruited from individuals who visited investigator's hospital for physical examination during the same time period.

Brief summary: Compelling epidemiological evidence indicates that alterations length of telomere, are associated with the initiation and development of ischemic heart disease. This study was undertaken to investigate whether mtDNA copy number in peripheral blood leukocyte could be used as a risk predictor for acute coronary syndrome.


Eligibility criteria: Inclusion Criteria:

-1.History of documented myocardial infarction; 2.Prior coronary revascularization intervention (coronary artery bypass graft surgery or percutaneous coronary intervention); 3.The presence of≥50% stenosis in one or more coronary arteries identified during cardiac catheterization;

Exclusion Criteria:

-1.History of malignancy or end-stage renal disease; 2.Blood transfusion within one month or prior bone marrow transplantation 3.Patients who reluctant to sign informed consent

Primary outcomes:
measure: Relative telomere length
timeFrame: From date of percutaneous coronary intervention until the date of discharging from hospital, assessed up to 5 days
Secondary outcomes:
Other outcomes:
Locations:
city: Xi'an
country: China
facility: Xijing Hospital
state: Shaanxi
Study officials:
References:
Clinical trial NCT01622179: Outcome of Two Different Suture Methods for Achilles Tendon Rupture
Official title: Closed Achilles Tendon Rupture Treats by Two Different Suture Methods and the Outcome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Achilles Tendon Rupture
Keywords: surgery
suture method
blood supply
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
First posted: 2012-06-19
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to estimate the effective of two suture methods in the treatment of Achilles rupture.

Detailed description: Achilles tendon rupture is one of the most common tendon injuries in the adult population. The incidence of this injury is increasing as aging adults continue their participation in high-demand sports. Although the impact of an Achilles tendon rupture is substantial, often resulting in prolonged disability and rehabilitation. Studies have showed that the operation treatment of acute Achilles tendon ruptures had some advantages. But the rebuild of blood supply was not involved in previous studies. And the epitenon of tendon is the interior layer, closest to the endotenons which contains the vascular supply. Main difference of two suture methods were if the epitenon was repaired and sewed indirectly or unrepaired and sewed directly.

Eligibility criteria: Inclusion Criteria:

* Adult men or women between 18 and 60 years of age.
* Closed rupture confirmed with ultrasound or magnetic resonance imaging (MRI).
* Operative within 14 days after injury.
* Willing and able to comply with and carry out the prescribed rehabilitation protocol.
* Providing informed consent.
* No other major trauma.

Exclusion Criteria:

* Refuse to participate.
* Refuse to participate.
* Additional ipsilateral injury.
* Open injury.
* Patients not suitable for surgery (i.e., mellitus diabetes, immunocompromised states, obesity (BMI.30), peripheral vascular disease or local/systemic dermatologic disorders) or have other surgical contraindications.
* Fluoroquinolone-associated rupture (i.e., rupture within 2 weeks after taking this medication).
* Achilles avulsion from the calcaneus or with bone fracture.
* Neurological or vascular disease requiring medications recognized to impair tendon healing.

Primary outcomes:
measure: Blood supply condition
timeFrame: six weeks
Secondary outcomes:
measure: Calf circumference
timeFrame: six weeks
measure: Complications
timeFrame: six months
Other outcomes:
Locations:
city: Beijing
country: China
facility: Orthopedics department; The General Hospital of the People's Liberation Army
state: Beijing
Study officials:
affiliation: Chinese PLA General Hospital
name: Tang P Fu
role: STUDY_CHAIR
References:
Clinical trial NCT03174379: A Study to Analyze the Effect of Acupuncture on Mobility And Quality of Life in Multiple Sclerosis
Official title: A Pilot Study to Analyze the Effect of Acupuncture on Mobility And Quality of Life in Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Multiple Sclerosis
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
First posted: 2017-06-02
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this two-center study is to examine the effectiveness of acupuncture treatments in addressing mobility deficits, sensorimotor impairment, and quality of life (QOL) limitations in persons with Multiple Sclerosis (MS). It is hypothesized that acupuncture will result in an improvement in these limitations.

Detailed description: This research study will examine the effects of acupuncture on various symptoms experienced by persons with MS. Persons with MS often use acupuncture as a way of controlling the symptoms of the disease. However, there is little research on whether or not acupuncture has any effect on MS symptoms related to movement. This study intends to look at the effects of acupuncture treatment on walking, balance, and mood in persons with MS.

Eligibility criteria: Inclusion Criteria:

* diagnosis of MS
* ability to walk unaided for 6 minutes with or without assistive device

Exclusion Criteria:

* bleeding precautions
* trypanophobia
* inability to lie still for 30 minutes
* active cancer, current exacerbation, and history of previous acupuncture treatment

Primary outcomes:
measure: fatigue severity scale
timeFrame: 14 Weeks
measure: Medical Outcomes Study Pain Effects Scale
timeFrame: 14 Weeks
measure: Gait measured by 6-minute walk test
timeFrame: 14 Weeks
measure: Balance measured by 25-foot walk test
timeFrame: 14 Weeks
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: New York University School of Medicine
state: New York
Study officials:
affiliation: NYU Langone Health
name: Barbara Siminovich-blok
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00940979: Trial Using Integuseal as Microbial Sealant for Arterial Bypass Surgery on Lower Extremities
Official title: Prospective Randomised Trial Using Integuseal as Microbial Sealant for Arterial Bypass Surgery on Lower Extremities
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Arterial Obstructive Diseases
Keywords: Integuseal microbial sealant
Infection prophylaxis
Postoperative wound infection
Arterial bypass surgery
Lead sponsor: Rijnstate Hospital
Sponsor class: OTHER
Collaborators: name: Kimberly-Clark Corporation
First posted: 2009-07-17
Enrollment: 450
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to prove a reduction of postoperative wound infections after direct preoperative use of a microbial sealant in the form of Integuseal for vascular procedures on lower extremities.


Eligibility criteria: Inclusion Criteria:

* planned supragenual of infragenual peripheral arterial bypass procedures with autologue or prosthetic graft

Exclusion Criteria:

* secondary procedures and suprainguinal procedures

Primary outcomes:
measure: Postoperative wound infections
Secondary outcomes:
measure: Costs of the use of Integuseal
measure: Complications during hospital stay
Other outcomes:
Locations:
city: Arnhem
country: Netherlands
facility: Ziekenhuis Rijnstate
city: Doetinchem
country: Netherlands
facility: Ziekenhuis Slingland
city: Drachten
country: Netherlands
facility: Ziekenhuis Nij Smellinghe
Study officials:
affiliation: Rijstate hospital Arnhem the Netherlands
name: Michel MPJ Reijnen, MD
role: STUDY_DIRECTOR
name: J. Klinkenbijl, MD
role: STUDY_DIRECTOR
affiliation: Rijnstate Hospital Arnhem the Netherlands
name: Sjoerd A de Beer, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00700479: Studies on Aldosterone and Vascular Function
Official title: Studies on Aldosterone and Vascular Function
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Inflammation
Keywords: vascular endothelium
nitric oxide
aldosterone
vascular biology
Lead sponsor: Yale University
Sponsor class: OTHER
Collaborators: name: Pfizer
First posted: 2008-06-18
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: A randomized crossover trial to determine the effects of sodium loading and aldosterone infusion on endothelial function in normal subjects.


Eligibility criteria: Inclusion Criteria:

* Healthy subjects age \>18 years

Exclusion Criteria:

* Any chronic medical disease or chronic use of medications

Primary outcomes:
measure: Flow mediated dilation brachial artery
timeFrame: 0 and 4 hours
Secondary outcomes:
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Yale University School of Medicine
state: Connecticut
Study officials:
affiliation: Yale University
name: Stuart Katz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00787579: Assessment of Bifocal and Prismatic Bifocal Spectacles for Myopia Control in Children
Official title: Assessment of Bifocal and Prismatic Bifocal Spectacles for Myopia Control in Children
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myopia
Keywords: Myopia, bifocal, children
Lead sponsor: Essilor International
Sponsor class: INDUSTRY
Collaborators: name: Queensland University of Technology
First posted: 2008-11-07
Enrollment: 135
Sex: ALL
Minimum age (years): 8
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: 1. To determine if the effect of near-addition lenses (bifocals) is more prominent for children with high myopia progression.
2. To study how different subject characteristics such as age, gender, baseline degree of myopia, baseline near phoria and baseline lag of accommodation affect the efficacy of bifocal lens wear in myopic children.
3. To investigate the effect of incorporating near base-in prisms along with the near-addition lenses (prismatic bifocals) on myopia progression in myopic children.


Eligibility criteria: Inclusion Criteria:

* Age: 8 to 13 years
* Myopia: -1.00 to -5.00 D
* Myopia progression: at least 0.50 D/yr
* Astigmatism and anisometropia: not more than 1.50 D
* Distance monocular visual acuity: 6/6 or better
* Near monocular visual acuity: 0.4 M or better
* Stereoacuity: not more than 40 sec of arc at 40 cm

Exclusion Criteria:

* Strabismus
* Ocular diseases

Primary outcomes:
measure: Myopia progression, measured by cycloplegic autorefraction
timeFrame: Every 6 months
Secondary outcomes:
measure: Axial length, measured by A-scan ultrasonography
timeFrame: Every 6 months
Other outcomes:
Locations:
city: Mississauga
country: Canada
facility: Dr. Desmond Cheng & Associates
state: Ontario
Study officials:
affiliation: Queensland University of Technology
name: Desmond Cheng, OD, MSc
role: PRINCIPAL_INVESTIGATOR
References:
citation: Cheng D, Woo GC, Drobe B, Schmid KL. Effect of bifocal and prismatic bifocal spectacles on myopia progression in children: three-year results of a randomized clinical trial. JAMA Ophthalmol. 2014 Mar;132(3):258-64. doi: 10.1001/jamaophthalmol.2013.7623.
citation: Cheng D, Schmid KL, Woo GC, Drobe B. Randomized trial of effect of bifocal and prismatic bifocal spectacles on myopic progression: two-year results. Arch Ophthalmol. 2010 Jan;128(1):12-9. doi: 10.1001/archophthalmol.2009.332.
Clinical trial NCT05939479: Antistaphylococcal Betalactam and Emergence of Resistance
Official title: Impact of Antistaphylococcal Penicillins and Cefazolin on the Emergence of Resistance in French Hospitals
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bacterial Resistance
Methicillin-Sensitive Staphylococcus Aureus Infection
Keywords: cefazolin
antistaphylococcal penicillins
Methicillin-Sensitive Staphylococcus Aureus Infection
Bacterial Resistance
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2023-07-11
Enrollment: 644
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All the patients hospitalized in included French hospitals

Brief summary: Antistaphylococcal penicillins are recommanded as first-line agent in methicillin-suceptible Staphylococcus aureus bacteraemia. Several studies in progress are investigating the efficacy and safety of cefazolin compared with antistaphylococcal penicillins. Cefazolin has broader spectrum than antistaphylococcal penicillins. The hypothesis of this project is that cefazoline could be responsible for a higher rate of bacterial resistance. The aim is to study the association between the emergence of bacterial resistance and the consumption of cefazolin and antistaphylococcal penicillins.


Eligibility criteria: Inclusion Criteria: French hospitals which have collected their consumption and resistance data on the French national database named CONSORES (From 2019 to 2022)

Exclusion Criteria:

* None

Primary outcomes:
measure: Association between the cefazolin/antistaphylococcal penicillins consumptions and the resistant bacteria emergence
timeFrame: Between the first january 2018 and the 31st december 2022
Secondary outcomes:
measure: Factors associated with the emergence of resistant bacteria
timeFrame: Between the first january 2018 and the 31st december 2022
measure: Factors associated with the consumption of antibiotics
timeFrame: Between the first january 2018 and the 31st december 2022
measure: Evolution of resistance in French hospitals
timeFrame: Between the first january 2018 and the 31st december 2022
measure: Evolution of antibiotics consumption in French hospitals
timeFrame: Between the first january 2018 and the 31st december 2022
Other outcomes:
Locations:
city: Nancy
country: France
facility: Lefevre
state: Lorraine
Study officials:
References:
Clinical trial NCT05500079: Transctunaous Pulsed Radiofrequency Therapy in Carpal Tunnel Syndrome
Official title: Efficacy of Transctunaous Pulsed Radiofrequency Therapy in Carpal Tunnel Syndrome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Peripheral Neuropathy
Chronic Pain
Keywords: carpal tunnel syndrome
pulsed radiofrequency treatment
transcutaneous pulsed radiofrequency
Lead sponsor: Diskapi Teaching and Research Hospital
Sponsor class: OTHER
First posted: 2022-08-12
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to examine the effect of transcutaneous pulsed radiofrequency current in the treatment of carpal tunnel syndrome.

Detailed description: Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy. Wrist splint is the first-line treatment option for CTS. Pulsed radiofrequency therapy is used in the treatment of chronic pain.

60 carpal tunnel syndrome patients diagnosed with electroneuromyelography will be included in the study. 30 patients will wear wrist splints for 1 month. In the other 30 patients, pulsed radiofrequency current will be given through the wrist median nerve trace. RF current will be applied through transcutaneous pads. It will be applied once a week for a total of 2 sessions, 8 minutes each. Boston carpal tunnel syndrome questionnaire with visual analog scale (VAS) will be applied to all patients before and after the treatment at 1 week and 1 month.

Our aim is to compare the effectiveness of wrist splint and pulsed rf therapy.

Eligibility criteria: Inclusion Criteria:

* Carpal tunnel syndrome detected by electroneuromyography
* Positive Tinel sign

Exclusion Criteria:

* Thenar muscle atrophy
* Weakness in the abductor pollicis brevis muscle

Primary outcomes:
measure: Change From Baseline in Pain on the Visual Analog Scale (VAS) at Week 2 and 4
timeFrame: Baseline, Week 2 and 4
measure: Boston Carpal Tunnel Syndrome Questionnaire before treatment
timeFrame: Before treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Diskapi Yildirim Beyazıt Teaching and Research Hospital
state: Dişkapi
Study officials:
affiliation: Diskapi TRH
name: mehlika panpallı ateş
role: STUDY_CHAIR
affiliation: Diskapi TRH
name: ömer taylan akkaya
role: STUDY_DIRECTOR
affiliation: Diskapi TRH
name: Hüseyin Alp Alptekin
role: STUDY_CHAIR
References: