Clinical trial NCT00206310: Crestor Versus Placebo in Subjects With Heart Failure
Official title: Controlled Rosuvastatin Multinational Study in Heart Failure CORONA A Randomized, Double-Blind, Placebo Controlled Phase III Study With Rosuvastatin in Subjects With Chronic Symptomatic Systolic Heart Failure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Heart Failure
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2005-09-21
Enrollment: 5013
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to investigate if rosuvastatin, added on top of all other medicines prescribed to subjects with symptomatic systolic heart failure, reduces the combined endpoint of cardiovascular death or non-fatal myocardial infarction or non-fatal stroke (time to first event)


Eligibility criteria: Inclusion Criteria:

* Chronic symptomatic systolic heart failure of ischaemic aetiology as judged by the investigator, optimal therapy for chronic symptomatic systolic heart failure according to the investigator

Exclusion Criteria:

* Acute myocardial infarction within 6 months before randomization
* Treatment with any statin or other lipid lowering drug; or a medical condition that in the opinion of the investigator requires treatment with a statin or other lipid lowering drug

Primary outcomes:
measure: The primary objective of this study is to determine whether rosuvastatin reduces the combined endpoint of cardiovascular death or non-fatal myocardial infarction (MI) or non-fatal stroke (time to first event).
Secondary outcomes:
measure: The secondary objectives are to evaluate the effects of rosuvastatin on:
measure: Total mortality
measure: Any coronary event defined as the combined endpoint of sudden death or fatal or non-fatal MI or Percutaneous Transluminal Coronary Angioplasty (PTCA) or Coronary Artery Bypass Grafting (CABG) or defibrillation of ventricular fibrillation by an implant
measure: Cardiovascular mortality with cause-specific mortality for sudden death; fatal MI; and death from worsening heart failure
measure: Total number of hospitalizations for cardiovascular causes; for unstable angina; and for worsening heart failure
Other outcomes:
Locations:
city: Aalst
country: Belgium
facility: Research Site
city: Bouge
country: Belgium
facility: Research Site
city: Brugge
country: Belgium
facility: Research Site
city: Brussels
country: Belgium
facility: Research Site
city: Edegem
country: Belgium
facility: Research Site
city: Ensival
country: Belgium
facility: Research Site
city: Fléron
country: Belgium
facility: Research Site
city: Genk
country: Belgium
facility: Research Site
city: Huy
country: Belgium
facility: Research Site
city: Leuven
country: Belgium
facility: Research Site
city: Mol
country: Belgium
facility: Research Site
city: Turnhout
country: Belgium
facility: Research Site
city: Verviers
country: Belgium
facility: Research Site
city: Pleven
country: Bulgaria
facility: Research Site
city: Plovdiv
country: Bulgaria
facility: Research Site
city: Russe
country: Bulgaria
facility: Research Site
city: Sofia
country: Bulgaria
facility: Research Site
city: Varna
country: Bulgaria
facility: Research Site
city: Bene¿ov u Prahy
country: Czech Republic
facility: Research Site
city: Bene¿ov
country: Czech Republic
facility: Research Site
city: Brno
country: Czech Republic
facility: Research Site
city: Hradec Králové 5
country: Czech Republic
facility: Research Site
city: Hradec Králové
country: Czech Republic
facility: Research Site
city: Jihlava
country: Czech Republic
facility: Research Site
city: Kladno
country: Czech Republic
facility: Research Site
city: Liberec
country: Czech Republic
facility: Research Site
city: Ostrava 1
country: Czech Republic
facility: Research Site
city: Ostrava 3 - Vítkovice
country: Czech Republic
facility: Research Site
city: Ostrava
country: Czech Republic
facility: Research Site
city: Pelh¿imov
country: Czech Republic
facility: Research Site
city: Plze¿-Bory
country: Czech Republic
facility: Research Site
city: Plze¿
country: Czech Republic
facility: Research Site
city: Praha 10
country: Czech Republic
facility: Research Site
city: Praha 1
country: Czech Republic
facility: Research Site
city: Praha 2
country: Czech Republic
facility: Research Site
city: Praha 5
country: Czech Republic
facility: Research Site
city: Praha 6
country: Czech Republic
facility: Research Site
city: P¿íbram V - Zdabo¿
country: Czech Republic
facility: Research Site
city: P¿íbram
country: Czech Republic
facility: Research Site
city: Slaný
country: Czech Republic
facility: Research Site
city: Tábor
country: Czech Republic
facility: Research Site
city: ¿eská Lípa
country: Czech Republic
facility: Research Site
city: ¿eské Bud¿jovice
country: Czech Republic
facility: Research Site
city: Ústí nad Labem
country: Czech Republic
facility: Research Site
city: Aalborg
country: Denmark
facility: Research Site
city: Esbjerg
country: Denmark
facility: Research Site
city: Frederiksberg
country: Denmark
facility: Research Site
city: Frederikssund
country: Denmark
facility: Research Site
city: Glostrup
country: Denmark
facility: Research Site
city: Haderslev
country: Denmark
facility: Research Site
city: Helsingør
country: Denmark
facility: Research Site
city: Horsens
country: Denmark
facility: Research Site
city: Hvidovre
country: Denmark
facility: Research Site
city: Kbh. S
country: Denmark
facility: Research Site
city: Kolding
country: Denmark
facility: Research Site
city: København N
country: Denmark
facility: Research Site
city: København Ø
country: Denmark
facility: Research Site
city: København
country: Denmark
facility: Research Site
city: Næstved
country: Denmark
facility: Research Site
city: Odense C
country: Denmark
facility: Research Site
city: Roskilde
country: Denmark
facility: Research Site
city: Svendborg
country: Denmark
facility: Research Site
city: Viborg
country: Denmark
facility: Research Site
city: Helsinki
country: Finland
facility: Research Site
city: Hyvinkää
country: Finland
facility: Research Site
city: Kemi
country: Finland
facility: Research Site
city: Kokkola
country: Finland
facility: Research Site
city: Lahti
country: Finland
facility: Research Site
city: Lappeenranta
country: Finland
facility: Research Site
city: Mariehamn
country: Finland
facility: Research Site
city: Oulu
country: Finland
facility: Research Site
city: Pietarsaari
country: Finland
facility: Research Site
city: Porvoo
country: Finland
facility: Research Site
city: Seinäjoki
country: Finland
facility: Research Site
city: Tampere
country: Finland
facility: Research Site
city: Uusikaupunki
country: Finland
facility: Research Site
city: Allauch
country: France
facility: Research Site
city: Antony
country: France
facility: Research Site
city: Arras
country: France
facility: Research Site
city: Cambrai Cedex
country: France
facility: Research Site
city: Cergy Pontoise
country: France
facility: Research Site
city: Chambray Les Tours
country: France
facility: Research Site
city: Chantepie
country: France
facility: Research Site
city: CHOLET Cedex
country: France
facility: Research Site
city: Croix
country: France
facility: Research Site
city: Dechy
country: France
facility: Research Site
city: Gonesse
country: France
facility: Research Site
city: Grenoble Cedex 9
country: France
facility: Research Site
city: Le Coudray
country: France
facility: Research Site
city: Lille
country: France
facility: Research Site
city: Montfermeil
country: France
facility: Research Site
city: Nantes Cedex 2
country: France
facility: Research Site
city: Paris
country: France
facility: Research Site
city: Pessac
country: France
facility: Research Site
city: Rennes
country: France
facility: Research Site
city: Roubaix
country: France
facility: Research Site
city: SAINT DENIS Cedex
country: France
facility: Research Site
city: Saint Herblain
country: France
facility: Research Site
city: Salouel
country: France
facility: Research Site
city: Senlis
country: France
facility: Research Site
city: Six Fours Les Plages
country: France
facility: Research Site
city: Toulouse
country: France
facility: Research Site
city: Tourcoing
country: France
facility: Research Site
city: Valenciennes
country: France
facility: Research Site
city: Stuttgart
country: Germany
facility: Research Site
state: Baden-Württemberg
city: München
country: Germany
facility: Research Site
state: Bayern
city: Regensburg
country: Germany
facility: Research Site
state: Bayern
city: Cottbus
country: Germany
facility: Research Site
state: Brandenburg
city: Frankfurt
country: Germany
facility: Research Site
state: Hessen
city: Greifswald
country: Germany
facility: Research Site
state: Mecklenburg-Vorpommern
city: Göttingen
country: Germany
facility: Research Site
state: Niedersachsen
city: Hannover
country: Germany
facility: Research Site
state: Niedersachsen
city: Düsseldorf
country: Germany
facility: Research Site
state: Nordrhein-Westfalen
city: Saarbrücken
country: Germany
facility: Research Site
state: Saarland
city: Halle
country: Germany
facility: Research Site
state: Sachsen-Anhalt
city: Dresden
country: Germany
facility: Research Site
state: Sachsen
city: Leipzig
country: Germany
facility: Research Site
state: Sachsen
city: Bad Segeberg
country: Germany
facility: Research Site
state: Schleswig-Holstein
city: Lübeck
country: Germany
facility: Research Site
state: Schleswig-Holstein
city: Jena-Maua
country: Germany
facility: Research Site
state: Thüringen
city: Aachen
country: Germany
facility: Research Site
city: Bad Nauheim
country: Germany
facility: Research Site
city: Bad Neustadt
country: Germany
facility: Research Site
city: Bad Wörishofen
country: Germany
facility: Research Site
city: Berlin
country: Germany
facility: Research Site
city: Brandenburg
country: Germany
facility: Research Site
city: Braunschweig
country: Germany
facility: Research Site
city: Coburg
country: Germany
facility: Research Site
city: Cottbus
country: Germany
facility: Research Site
city: Dillingen
country: Germany
facility: Research Site
city: Dresden
country: Germany
facility: Research Site
city: Erfurt
country: Germany
facility: Research Site
city: Essen
country: Germany
facility: Research Site
city: Esslingen
country: Germany
facility: Research Site
city: Greifswald
country: Germany
facility: Research Site
city: Görlitz
country: Germany
facility: Research Site
city: Göttingen
country: Germany
facility: Research Site
city: Halle
country: Germany
facility: Research Site
city: Hamburg
country: Germany
facility: Research Site
city: Kassel
country: Germany
facility: Research Site
city: Leipzig
country: Germany
facility: Research Site
city: Leisnig
country: Germany
facility: Research Site
city: Löbau
country: Germany
facility: Research Site
city: Lübeck
country: Germany
facility: Research Site
city: Mannheim
country: Germany
facility: Research Site
city: München
country: Germany
facility: Research Site
city: Neustadt/Aisch
country: Germany
facility: Research Site
city: Norderstedt
country: Germany
facility: Research Site
city: Nordhorn
country: Germany
facility: Research Site
city: Regensburg
country: Germany
facility: Research Site
city: Riesa
country: Germany
facility: Research Site
city: Rüdersdorf
country: Germany
facility: Research Site
city: Timmendorfer Strand
country: Germany
facility: Research Site
city: Tübingen
country: Germany
facility: Research Site
city: Vechta
country: Germany
facility: Research Site
city: Wedel
country: Germany
facility: Research Site
city: Wermsdorf
country: Germany
facility: Research Site
city: Wolmirstedt
country: Germany
facility: Research Site
city: Balatonfüred
country: Hungary
facility: Research Site
city: Budapest
country: Hungary
facility: Research Site
city: Cegléd
country: Hungary
facility: Research Site
city: Debrecen
country: Hungary
facility: Research Site
city: Eger
country: Hungary
facility: Research Site
city: Gyula
country: Hungary
facility: Research Site
city: Kecskemét
country: Hungary
facility: Research Site
city: Mosonmagyaróvár
country: Hungary
facility: Research Site
city: Sopron
country: Hungary
facility: Research Site
city: Szentes
country: Hungary
facility: Research Site
city: Szolnok
country: Hungary
facility: Research Site
city: Székesfehérvár
country: Hungary
facility: Research Site
city: Ballinasloe
country: Ireland
facility: Research Site
state: Co. Galway
city: Dublin 8
country: Ireland
facility: Research Site
city: Ryhope, SUNDERLAND
country: Ireland
facility: Research Site
city: Alkmaar
country: Netherlands
facility: Research Site
city: Almelo
country: Netherlands
facility: Research Site
city: Amersfoort
country: Netherlands
facility: Research Site
city: Amsterdam
country: Netherlands
facility: Research Site
city: Apeldoorn
country: Netherlands
facility: Research Site
city: Blaricum
country: Netherlands
facility: Research Site
city: Breda
country: Netherlands
facility: Research Site
city: Capelle Aan Den Ijssel
country: Netherlands
facility: Research Site
city: Delft
country: Netherlands
facility: Research Site
city: Den Bosch
country: Netherlands
facility: Research Site
city: Den Haag
country: Netherlands
facility: Research Site
city: Den Helder
country: Netherlands
facility: Research Site
city: Deventer
country: Netherlands
facility: Research Site
city: Dirksland
country: Netherlands
facility: Research Site
city: Dordrecht
country: Netherlands
facility: Research Site
city: EDE
country: Netherlands
facility: Research Site
city: Enschede
country: Netherlands
facility: Research Site
city: Goes
country: Netherlands
facility: Research Site
city: Gorinchem
country: Netherlands
facility: Research Site
city: Gouda
country: Netherlands
facility: Research Site
city: Groningen
country: Netherlands
facility: Research Site
city: Haarlem
country: Netherlands
facility: Research Site
city: Hardenberg
country: Netherlands
facility: Research Site
city: Heerenveen
country: Netherlands
facility: Research Site
city: Heerlen
country: Netherlands
facility: Research Site
city: Helmond
country: Netherlands
facility: Research Site
city: Hengelo
country: Netherlands
facility: Research Site
city: Hilversum
country: Netherlands
facility: Research Site
city: Hoofddorp
country: Netherlands
facility: Research Site
city: Leiden
country: Netherlands
facility: Research Site
city: Lelystad
country: Netherlands
facility: Research Site
city: Maastricht
country: Netherlands
facility: Research Site
city: Nijmegen
country: Netherlands
facility: Research Site
city: OSS
country: Netherlands
facility: Research Site
city: Roermond
country: Netherlands
facility: Research Site
city: Roosendaal
country: Netherlands
facility: Research Site
city: Rotterdam
country: Netherlands
facility: Research Site
city: Schiedam
country: Netherlands
facility: Research Site
city: Sittard
country: Netherlands
facility: Research Site
city: Sneek
country: Netherlands
facility: Research Site
city: Tiel
country: Netherlands
facility: Research Site
city: Tilburg
country: Netherlands
facility: Research Site
city: Veldhoven
country: Netherlands
facility: Research Site
city: Velp
country: Netherlands
facility: Research Site
city: Venlo
country: Netherlands
facility: Research Site
city: Zeist
country: Netherlands
facility: Research Site
city: Zoetermeer
country: Netherlands
facility: Research Site
city: Zwolle
country: Netherlands
facility: Research Site
city: Arendal
country: Norway
facility: Research Site
city: Drammen
country: Norway
facility: Research Site
city: Flekkefjord
country: Norway
facility: Research Site
city: Fredrikstad
country: Norway
facility: Research Site
city: Førde
country: Norway
facility: Research Site
city: Gjettum
country: Norway
facility: Research Site
city: Gjøvik
country: Norway
facility: Research Site
city: Hamar
country: Norway
facility: Research Site
city: Lillehammer
country: Norway
facility: Research Site
city: Oslo
country: Norway
facility: Research Site
city: Porsgrunn
country: Norway
facility: Research Site
city: Tromsø
country: Norway
facility: Research Site
city: Bialystok
country: Poland
facility: Research Site
city: Bia¿ystok
country: Poland
facility: Research Site
city: Bydgoszcz
country: Poland
facility: Research Site
city: Chojnice
country: Poland
facility: Research Site
city: Gdansk
country: Poland
facility: Research Site
city: Gdynia
country: Poland
facility: Research Site
city: Gliwice
country: Poland
facility: Research Site
city: Inowroc¿aw
country: Poland
facility: Research Site
city: I¿awa
country: Poland
facility: Research Site
city: Katowice
country: Poland
facility: Research Site
city: Kielce
country: Poland
facility: Research Site
city: Lodz
country: Poland
facility: Research Site
city: Lublin
country: Poland
facility: Research Site
city: Olsztyn
country: Poland
facility: Research Site
city: Ostrowiec ¿wi¿tokrzyski
country: Poland
facility: Research Site
city: O¿awa
country: Poland
facility: Research Site
city: Piotrków Trybunalski
country: Poland
facility: Research Site
city: Poznan
country: Poland
facility: Research Site
city: Ruda ¿l¿ska
country: Poland
facility: Research Site
city: Siedlce
country: Poland
facility: Research Site
city: Skierniewice
country: Poland
facility: Research Site
city: Warszawa
country: Poland
facility: Research Site
city: Wroclaw
country: Poland
facility: Research Site
city: Zabrze
country: Poland
facility: Research Site
city: Zamo¿¿
country: Poland
facility: Research Site
city: ¿yrardów
country: Poland
facility: Research Site
city: ¿ód¿
country: Poland
facility: Research Site
city: Almada
country: Portugal
facility: Research Site
city: Amadora
country: Portugal
facility: Research Site
city: Barreiro
country: Portugal
facility: Research Site
city: Carnaxide
country: Portugal
facility: Research Site
city: Coimbra
country: Portugal
facility: Research Site
city: Funchal
country: Portugal
facility: Research Site
city: Lisboa
country: Portugal
facility: Research Site
city: Penafiel
country: Portugal
facility: Research Site
city: Porto
country: Portugal
facility: Research Site
city: Vila Franca de Xira
country: Portugal
facility: Research Site
city: Brasov
country: Romania
facility: Research Site
city: Bucharest
country: Romania
facility: Research Site
city: Cluj-Napoca
country: Romania
facility: Research Site
city: Craiova
country: Romania
facility: Research Site
city: Targu-Mures
country: Romania
facility: Research Site
city: Moscow
country: Russian Federation
facility: Research Site
state: Russia
city: Bardejov
country: Slovakia
facility: Research Site
city: Bratislava
country: Slovakia
facility: Research Site
city: Dolný Kubín
country: Slovakia
facility: Research Site
city: Ko¿ice
country: Slovakia
facility: Research Site
city: Lu¿enec
country: Slovakia
facility: Research Site
city: Nitra
country: Slovakia
facility: Research Site
city: Nové Zámky
country: Slovakia
facility: Research Site
city: Pre¿ov
country: Slovakia
facility: Research Site
city: Rimavská Sobota
country: Slovakia
facility: Research Site
city: Bloemfontein
country: South Africa
facility: Research Site
state: Free State
city: Soweto
country: South Africa
facility: Research Site
state: Gauteng
city: Durban
country: South Africa
facility: Research Site
state: KwaZulu Natal
city: Somerset West
country: South Africa
facility: Research Site
state: Western Cape
city: Bloemfontein
country: South Africa
facility: Research Site
city: Cape Town
country: South Africa
facility: Research Site
city: Lyttelton Manor
country: South Africa
facility: Research Site
city: Parktown
country: South Africa
facility: Research Site
city: Tygerberg
country: South Africa
facility: Research Site
city: Santiago de Compostela
country: Spain
facility: Research Site
state: A Coruña
city: Santiago
country: Spain
facility: Research Site
state: A Coruña
city: San Juan
country: Spain
facility: Research Site
state: Alicante
city: Badalona
country: Spain
facility: Research Site
state: Barcelona
city: Terrassa
country: Spain
facility: Research Site
state: Barcelona
city: A Coruña
country: Spain
facility: Research Site
state: Galicia
city: San Sebastián
country: Spain
facility: Research Site
state: Guipuzcoa
city: Alcorcón
country: Spain
facility: Research Site
state: Madrid
city: Marbella
country: Spain
facility: Research Site
state: Málaga
city: Vigo
country: Spain
facility: Research Site
state: Pontevedra
city: Barcelona
country: Spain
facility: Research Site
city: Castellón
country: Spain
facility: Research Site
city: Madrid
country: Spain
facility: Research Site
city: Málaga
country: Spain
facility: Research Site
city: Palma de Mallorca
country: Spain
facility: Research Site
city: Salamanca
country: Spain
facility: Research Site
city: Santander
country: Spain
facility: Research Site
city: Sevilla
country: Spain
facility: Research Site
city: Danderyd
country: Sweden
facility: Research Site
city: Eksjö
country: Sweden
facility: Research Site
city: Enköping
country: Sweden
facility: Research Site
city: Göteborg
country: Sweden
facility: Research Site
city: Hudiksvall
country: Sweden
facility: Research Site
city: Jönköping
country: Sweden
facility: Research Site
city: Karlstad
country: Sweden
facility: Research Site
city: Linköping
country: Sweden
facility: Research Site
city: Lund
country: Sweden
facility: Research Site
city: Motala
country: Sweden
facility: Research Site
city: Mölndal
country: Sweden
facility: Research Site
city: Oskarshamn
country: Sweden
facility: Research Site
city: Stockholm
country: Sweden
facility: Research Site
city: Uppsala
country: Sweden
facility: Research Site
city: Västervik
country: Sweden
facility: Research Site
city: Ängelholm
country: Sweden
facility: Research Site
city: Bellinzona
country: Switzerland
facility: Research Site
city: Bern
country: Switzerland
facility: Research Site
city: Genève 14
country: Switzerland
facility: Research Site
city: Lugano
country: Switzerland
facility: Research Site
city: Schlieren
country: Switzerland
facility: Research Site
city: Zürich
country: Switzerland
facility: Research Site
city: Cottingham
country: United Kingdom
facility: Research Site
state: Hull
city: Sidcup
country: United Kingdom
facility: Research Site
state: Kent
city: Airdrie
country: United Kingdom
facility: Research Site
state: Lanarkshire
city: Essex
country: United Kingdom
facility: Research Site
state: London
city: Antrim
country: United Kingdom
facility: Research Site
state: Northern Ireland
city: Belfast
country: United Kingdom
facility: Research Site
state: Northern Ireland
city: Paisley
country: United Kingdom
facility: Research Site
state: Renfrewhsire
city: Bridgend
country: United Kingdom
facility: Research Site
state: Wales
city: Aberdeen
country: United Kingdom
facility: Research Site
city: Ayr
country: United Kingdom
facility: Research Site
city: Basingstoke
country: United Kingdom
facility: Research Site
city: Belfast
country: United Kingdom
facility: Research Site
city: Blackpool
country: United Kingdom
facility: Research Site
city: Bridgend
country: United Kingdom
facility: Research Site
city: Brighton
country: United Kingdom
facility: Research Site
city: Bristol
country: United Kingdom
facility: Research Site
city: Carshalton
country: United Kingdom
facility: Research Site
city: Croyden
country: United Kingdom
facility: Research Site
city: Croydon
country: United Kingdom
facility: Research Site
city: Durham
country: United Kingdom
facility: Research Site
city: East Kilbride
country: United Kingdom
facility: Research Site
city: Edinburgh
country: United Kingdom
facility: Research Site
city: Essex
country: United Kingdom
facility: Research Site
city: Glasgow
country: United Kingdom
facility: Research Site
city: Hastings
country: United Kingdom
facility: Research Site
city: High Wycombe
country: United Kingdom
facility: Research Site
city: Hull
country: United Kingdom
facility: Research Site
city: Kent
country: United Kingdom
facility: Research Site
city: Kirkcaldy
country: United Kingdom
facility: Research Site
city: Leicester
country: United Kingdom
facility: Research Site
city: Liverpool
country: United Kingdom
facility: Research Site
city: Llantrisant
country: United Kingdom
facility: Research Site
city: London
country: United Kingdom
facility: Research Site
city: Middlesex
country: United Kingdom
facility: Research Site
city: Newport
country: United Kingdom
facility: Research Site
city: Northumberland
country: United Kingdom
facility: Research Site
city: Paisley
country: United Kingdom
facility: Research Site
city: Poole
country: United Kingdom
facility: Research Site
city: Ryhope, SUNDERLAND
country: United Kingdom
facility: Research Site
city: Scunthorpe
country: United Kingdom
facility: Research Site
city: Sheffield
country: United Kingdom
facility: Research Site
city: Sunderland
country: United Kingdom
facility: Research Site
city: West Bromwich
country: United Kingdom
facility: Research Site
city: York
country: United Kingdom
facility: Research Site
Study officials:
affiliation: AstraZeneca
name: AstraZeneca Medical Science Director, MD
role: STUDY_DIRECTOR
References:
citation: Askevold ET, Gullestad L, Nymo S, Kjekshus J, Yndestad A, Latini R, Cleland JG, McMurray JJ, Aukrust P, Ueland T. Secreted Frizzled Related Protein 3 in Chronic Heart Failure: Analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). PLoS One. 2015 Aug 19;10(8):e0133970. doi: 10.1371/journal.pone.0133970. eCollection 2015.
citation: Perez AC, Jhund PS, Stott DJ, Gullestad L, Cleland JG, van Veldhuisen DJ, Wikstrand J, Kjekshus J, McMurray JJ. Thyroid-stimulating hormone and clinical outcomes: the CORONA trial (controlled rosuvastatin multinational study in heart failure). JACC Heart Fail. 2014 Feb;2(1):35-40. doi: 10.1016/j.jchf.2013.07.008. Epub 2014 Jan 25.
citation: Gravning J, Askevold ET, Nymo SH, Ueland T, Wikstrand J, McMurray JJ, Aukrust P, Gullestad L, Kjekshus J; CORONA Study Group. Prognostic effect of high-sensitive troponin T assessment in elderly patients with chronic heart failure: results from the CORONA trial. Circ Heart Fail. 2014 Jan;7(1):96-103. doi: 10.1161/CIRCHEARTFAILURE.113.000450. Epub 2013 Nov 27.
citation: Perez AC, Jhund P, Preiss D, Kjekshus J, McMurray JJ. Effect of rosuvastatin on fatigue in patients with heart failure. J Am Coll Cardiol. 2013 Mar 12;61(10):1121-2. doi: 10.1016/j.jacc.2012.12.004. No abstract available.
citation: van der Velde AR, Gullestad L, Ueland T, Aukrust P, Guo Y, Adourian A, Muntendam P, van Veldhuisen DJ, de Boer RA. Prognostic value of changes in galectin-3 levels over time in patients with heart failure: data from CORONA and COACH. Circ Heart Fail. 2013 Mar;6(2):219-26. doi: 10.1161/CIRCHEARTFAILURE.112.000129. Epub 2013 Feb 8.
citation: Askevold ET, Nymo S, Ueland T, Gravning J, Wergeland R, Kjekshus J, Yndestad A, Cleland JG, McMurray JJ, Aukrust P, Gullestad L. Soluble glycoprotein 130 predicts fatal outcomes in chronic heart failure: analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). Circ Heart Fail. 2013 Jan;6(1):91-8. doi: 10.1161/CIRCHEARTFAILURE.112.972653. Epub 2012 Dec 10.
citation: Gullestad L, Ueland T, Kjekshus J, Nymo SH, Hulthe J, Muntendam P, McMurray JJ, Wikstrand J, Aukrust P. The predictive value of galectin-3 for mortality and cardiovascular events in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). Am Heart J. 2012 Dec;164(6):878-83. doi: 10.1016/j.ahj.2012.08.021. Epub 2012 Oct 29.
citation: Latini R, Gullestad L, Masson S, Nymo SH, Ueland T, Cuccovillo I, Vardal M, Bottazzi B, Mantovani A, Lucci D, Masuda N, Sudo Y, Wikstrand J, Tognoni G, Aukrust P, Tavazzi L; Investigators of the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA) and GISSI-Heart Failure (GISSI-HF) trials. Pentraxin-3 in chronic heart failure: the CORONA and GISSI-HF trials. Eur J Heart Fail. 2012 Sep;14(9):992-9. doi: 10.1093/eurjhf/hfs092. Epub 2012 Jun 27.
citation: Stein EA, Vidt DG, Shepherd J, Cain VA, Anzalone D, Cressman MD. Renal safety of intensive cholesterol-lowering treatment with rosuvastatin: a retrospective analysis of renal adverse events among 40,600 participants in the rosuvastatin clinical development program. Atherosclerosis. 2012 Apr;221(2):471-7. doi: 10.1016/j.atherosclerosis.2011.12.011. Epub 2012 Jan 3.
citation: Ueland T, Dahl CP, Kjekshus J, Hulthe J, Bohm M, Mach F, Goudev A, Lindberg M, Wikstrand J, Aukrust P, Gullestad L. Osteoprotegerin predicts progression of chronic heart failure: results from CORONA. Circ Heart Fail. 2011 Mar;4(2):145-52. doi: 10.1161/CIRCHEARTFAILURE.110.957332. Epub 2011 Jan 7.
citation: McMurray JJ, Dunselman P, Wedel H, Cleland JG, Lindberg M, Hjalmarson A, Kjekshus J, Waagstein F, Apetrei E, Barrios V, Bohm M, Kamensky G, Komajda M, Mareev V, Wikstrand J; CORONA Study Group. Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure). J Am Coll Cardiol. 2010 Oct 5;56(15):1196-204. doi: 10.1016/j.jacc.2010.02.075.
citation: Inglis SC, McMurray JJ, Bohm M, Schaufelberger M, van Veldhuisen DJ, Lindberg M, Dunselman P, Hjalmarson A, Kjekshus J, Waagstein F, Wedel H, Wikstrand J; CORONA Study Group. Intermittent claudication as a predictor of outcome in patients with ischaemic systolic heart failure: analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure trial (CORONA). Eur J Heart Fail. 2010 Jul;12(7):698-705. doi: 10.1093/eurjhf/hfq070. Epub 2010 May 25.
citation: McMurray JJ, Kjekshus J, Gullestad L, Dunselman P, Hjalmarson A, Wedel H, Lindberg M, Waagstein F, Grande P, Hradec J, Kamensky G, Korewicki J, Kuusi T, Mach F, Ranjith N, Wikstrand J; CORONA Study Group. Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): a retrospective analysis. Circulation. 2009 Dec 1;120(22):2188-96. doi: 10.1161/CIRCULATIONAHA.109.849117. Epub 2009 Nov 16.
citation: Kjekshus J, Apetrei E, Barrios V, Bohm M, Cleland JG, Cornel JH, Dunselman P, Fonseca C, Goudev A, Grande P, Gullestad L, Hjalmarson A, Hradec J, Janosi A, Kamensky G, Komajda M, Korewicki J, Kuusi T, Mach F, Mareev V, McMurray JJ, Ranjith N, Schaufelberger M, Vanhaecke J, van Veldhuisen DJ, Waagstein F, Wedel H, Wikstrand J; CORONA Group. Rosuvastatin in older patients with systolic heart failure. N Engl J Med. 2007 Nov 29;357(22):2248-61. doi: 10.1056/NEJMoa0706201. Epub 2007 Nov 5.