Clinical trial NCT05344001: Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health
Official title: Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Aging
Athletic Injuries
Physical Inactivity
Knee Injuries and Disorders
Keywords: Sports Medicine
Injury
Athlete
Sport
Physical Activity
Function
Health
Knee
Lead sponsor: Marquette University
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2022-04-25
Enrollment: 450
Sex: ALL
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Current and former collegiate varsity athletes with and without a prior history of traumatic knee injury and matched non-athlete controls.

Brief summary: Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury and non-athlete controls is critical to understanding long-term health trajectories in athletes and informing potential interventional studies. One modifiable factor that may be associated with long-term health in athletes is physical activity patterns. The purpose of this study is to evaluate strength, function, physical activity, dietary patterns, and cardiometabolic health among current and former competitive athletes and in nonathlete controls to evaluate the impact of prior knee injury and sedentary behavior as two potential determinants of later poor health and reduced function.

Detailed description: The overarching hypothesis is that former athletes, especially those with a prior injury, will have poorer function and health in midlife and that current and former athletes will engage in greater overall and longer bouts of sedentary behavior compared to non-athletes.

Aim 1 will compare function, strength, and cardiometabolic indicators among former athletes with and without prior knee injury and non-athlete controls in midlife (age 40-64). Hypothesis 1 is that former athletes with a prior injury will have the poorest function, muscle strength, and cardiometabolic indicators.

Aim 2 will compare sedentary behavior and physical activity patterns in current (age 18-25) and midlife former athletes to non-athlete controls. Hypothesis 2.1 is that current athletes will have greater sedentary behavior, longer sedentary behavior bouts, and higher levels of moderate-to-vigorous physical activity compared to non-athlete controls. Hypothesis 2.2 is that former athletes in midlife will have greater sedentary behavior, longer sedentary behavior bouts, and lower physical activity levels compared to non-athlete controls.

An exploratory aim will evaluate longitudinally the trajectory of physical activity patterns, cardiometabolic indicators, function, and strength annually in each cohort, comparing how these variables change over time in each subgroup.

Eligibility criteria: Please see cohorts for specific inclusion/exclusion criteria

Inclusion Criteria:

* Age 18-25 years OR age 40-64 years
* Current or former collegiate varsity athlete OR non-athlete control

Exclusion Criteria:

* Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function
* Pregnancy
* Lower extremity joint replacement (e.g., hip or knee replacement)

Primary outcomes:
measure: 30-Second Chair Stand Test (primary outcome for Aim 1)
timeFrame: Baseline
measure: Sedentary Behavior (primary outcome for Aim 2)
timeFrame: Baseline
Secondary outcomes:
measure: Strength
timeFrame: Baseline
measure: Body Composition
timeFrame: Baseline
measure: Step Counts
timeFrame: Baseline
measure: Cardiovascular Disease Risk
timeFrame: Baseline
measure: 6-Minute Walk Test
timeFrame: Baseline
measure: Stair Climb Test
timeFrame: Baseline
measure: Sedentary Behavior (follow-up)
timeFrame: Follow-up (an average of 1 year post-baseline)
measure: 30-Second Chair Stand Test (follow-up)
timeFrame: Follow-up (an average of 1 year post-baseline)
measure: Strength (follow-up)
timeFrame: Follow-up (an average of 1 year post-baseline)
measure: Body Composition (follow-up)
timeFrame: Follow-up (an average of 1 year post-baseline)
measure: Step Counts (Follow-up)
timeFrame: Follow-up (an average of 1 year post-baseline)
measure: 6-Minute Walk Test (follow-up)
timeFrame: Follow-up (an average of 1 year post-baseline)
measure: Stair Climb Test (follow-up)
timeFrame: Follow-up (an average of 1 year post-baseline)
Other outcomes:
Locations:
city: Milwaukee
country: United States
facility: Marquette University
state: Wisconsin
Study officials:
affiliation: Marquette University
name: Jacob J. Capin, DPT, PhD, MS
role: PRINCIPAL_INVESTIGATOR
References: