Clinical trial NCT02215603: Effects of Disrupting Prolonged Sitting With Different Physical Activity Protocols on Metabolic Risk Factors in Sedentary Adults
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Prolonged Sitting
Breaking Prolonged Sitting With Physical Activity
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
Collaborators: name: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
First posted: 2014-08-13
Enrollment: 10
Sex: MALE
Minimum age (years): 25
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Great controversy exists with respect to the optimal or the minimum volume, intensity, and frequency of physical activity capable of attenuating the hazards of prolonged sitting on the metabolic profile. Thus, our study aims to comprehensively investigate the effects of disrupting prolonged sitting with different physical activity protocols on metabolic risk factors in sedentary males.

Ten sedentary males will take part in this randomized cross-over trial consisting of four 27-h conditions. All conditions will be identical except for the physical activity: prolonged sitting intervention (SIT) participants will sit continuously for 9 hours; prolonged sitting+interval standing intervention (STAND), participants will stand for 15 min every 30 minutes (total 270 min) during the 9 hours of sitting; prolonged sitting+moderate-intensity exercise bout (MVPA) participants will perform a 30-min moderate-intensity exercise bout on a treadmill (energy-matched to STAND), after which they will sit for the remaining time; and prolonged sitting+moderate-intensity exercise bout +interval standing intervention (MVPA-STAND), participants will perform a 30-min moderate-intensity exercise bout on a treadmill (energy-matched to STAND), after which they will stand for 15 min every 30 minutes (total 240 min) during the remaining 8 hours of sitting. Blood glucose, insulin, lipids and cytokines will be determined.

The investigators expect that disrupting prolonged sitting with intermittent standing and a moderate-exercise bout will positively affect the metabolic profile of the participants. Furthermore, we will investigate if combined, these strategies will have an additive effect.


Eligibility criteria: Inclusion Criteria:

* Males,
* age 25-55 y,
* BMI \>18 and \<35 kg/m2

Exclusion Criteria:

* Clinically diagnosed diabetes,
* dyslipidaemia,
* hypertension,
* use of glucose- and/or lipid-lowering medication,
* smoking,
* evidence of thyroid, liver, lung, heart or kidney disease,
* non-sedentary occupation and primary means of commuting to work (i.e., cycling) in the last 4 months,
* VO2max levels above the considered average fitness according to age,
* contraindication to increased levels of physical activity.

Primary outcomes:
measure: Area under the curve of glucose and insulin postprandial responses
timeFrame: 27 h
Secondary outcomes:
measure: Glucose levels
timeFrame: 27 hours
measure: Area under the curve of lipid postprandial responses
timeFrame: 27 h
Other outcomes:
measure: Area under the curve of cytokine postprandial responses
timeFrame: 27 h
Locations:
city: Copenhagen
country: Denmark
facility: Centre of Inflammation and Metabolism
Study officials:
References: