Clinical trial NCT06610110: Caffeine, CYPA12 and Resistance Exercise
Official title: Influence of CYP1A2 on the Acute Effect of Caffeine Intake on Resistance Exercise
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: CYP1A2 Polymorphism
Caffeine and Resistance Exercise
Lead sponsor: University of Alcala
Sponsor class: OTHER
Collaborators: name: University of Alcala
name: iSanidad+Herbalife
First posted: 2024-09-24
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, it remains to be elucidated how CYP1A2 polymorphism influences the acute effects of caffeine on this type of exercise.

Objectives: The present study aims to analyze the effects of acute caffeine intake on muscular strength, power, and endurance performance according to CYP1A2 polymorphism in men and women.


Eligibility criteria: Inclusion Criteria:

* Age between ≥ 18 and ≤ 35 years.
* Body mass index (BMI) lower than 25 kg/m².
* Physically active subjects (≥150 min/week of moderate exercise).
* Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
* Participants capable of performing the tests.

Exclusion Criteria:

* History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
* Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
* Body mass index (BMI) ≥ 25 kg/m².
* Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
* Performing strenuous exercise within 48 hours prior to the tests.
* Failing to replicate the same food intake on the two experimental days.
* Consuming caffeine after 6 PM on the day prior to training or testing.

Primary outcomes:
measure: cyp1a2 polymorphism
timeFrame: Before the beginning of the trial
measure: Mean velocity at different %1RM
timeFrame: Through study completion, an average of 2 weeks
measure: Peak velocity at different %1RM
timeFrame: Through study completion, an average of 2 weeks
measure: Mean power output at different %1RM
timeFrame: Through study completion, an average of 2 weeks
measure: Peak power output and time to reach peak power output at different %1RM
timeFrame: Through study completion, an average of 2 weeks
measure: Number of repetitions performed in 1 set at 65%1RM until task failure
timeFrame: Through study completion, an average of 2 weeks
measure: Bar velocity deplacement performed in 1 set at 65%1RM until task failure
timeFrame: Through study completion, an average of 2 weeks
measure: Power output generated in 1 set at 65%1RM until task failure
timeFrame: Through study completion, an average of 2 weeks
measure: Maximal Fat Oxidation Rate (MFO)
timeFrame: Through study completion, an average of 2 weeks
measure: Resting Metabolic Rate (RMR)
timeFrame: Through study completion, an average of 2 weeks
Secondary outcomes:
measure: Mood state (tension, depression, anger, vigor, fatigue and confusion)
timeFrame: Through study completion, an average of 2 weeks
measure: Adverse effects
timeFrame: Through study completion, an average of 2 weeks
measure: handgrip and isometric mid-thigh pull tests
timeFrame: Through study completion, an average of 2 weeks
measure: Vertical Jump (cm)
timeFrame: Through study completion, an average of 2 weeks
measure: Vertical Jump (power)
timeFrame: Through study completion, an average of 2 weeks
Other outcomes:
Locations:
city: Alcalá de Henares
country: Spain
facility: Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá
state: Madrid
city: Alcalá de Henares
country: Spain
facility: Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá
state: Madrid
Study officials:
References: