Clinical trial NCT03310502: Variation of Genes Controlling Carbohydrate and Lipid Metabolism
Official title: Variation of Genes Controlling Carbohydrate and Lipid Metabolism
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Cardiovascular Diseases
Obesity
Insulin Resistance
Lipid Metabolism Disorders
PreDiabetes
Keywords: positron emission tomography
skeletal muscle
liver
adipose tissue
brain
genetics
Lead sponsor: Turku University Hospital
Sponsor class: OTHER_GOV
Collaborators: name: University of Eastern Finland
name: Kuopio University Hospital
name: University of Turku
First posted: 2017-10-16
Enrollment: 2050
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study population consists of participants of previous studies measuring glucose metabolism, lipid metabolism, bloow flow and adiposity at Turku PET Centre. Important subgroups in this study population are healthy volunteers, participants with obesity, prediabetes, type 2 diabetes or cardiovascular disease.

Brief summary: Aim of the study is to investigate genes regulating glucose and lipid metabolism in subjects whose glucose metabolism, lipid metabolism, blood flow, or body fat distribution has been measured using positron emission tomography (PET), magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) or computed tomography (CT) as part of their previous participation in clinical trials conducted at Turku PET Centre.

By combining information from PET, MRI, CT, proteomics, metabolomics and genetics analyses we aim to find connection between genetic variation and metabolic and cardiovascular disease.

Detailed description: The data is collected as a separate part of the clinical imaging study protocols using a separate inform consent approved by the local ethics committee. The participation for this study consists of drawing whole blood, serum and plasma samples for genetics, proteomics and metabolomics analyses. The results from these studies are combined with baseline data from the original clinical imaging studies to find connections between genetic variation, metabolism, blood flow and body fat distribution in a cross-sectional setting.

Eligibility criteria: Inclusion Criteria:

* Previous participation of studies measuring glucose metabolism, lipid metabolism, bloow flow and adiposity at Turku PET Centre

Exclusion Criteria:

-

Primary outcomes:
measure: Skeletal muscle insulin sensitivity
timeFrame: Baseline
Secondary outcomes:
measure: Whole body insulin sensitivity
timeFrame: Baseline
measure: Visceral adipose tissue insulin sensitivity to glucose uptake
timeFrame: Baseline
measure: Abdominal subcutaneous adipose tissue insulin sensitivity to glucose uptake
timeFrame: Baseline
measure: Brown adipose tissue insulin sensitivity
timeFrame: Baseline
measure: Brown adipose tissue glucose uptake during cold exposure
timeFrame: Baseline
measure: Insulin sensitivity of adipose tissue lipolysis
timeFrame: Baseline
measure: Myocardial insulin sensitivity
timeFrame: Baseline
measure: Liver insulin sensitivity to glucose uptake
timeFrame: Baseline
measure: Endogenous glucose production
timeFrame: Baseline
measure: Brain insulin sensitivity to glucose uptake
timeFrame: Baseline
measure: Abdominal subcutaneous adipose tissue mass
timeFrame: Baseline
measure: Visceral adipose tissue mass
timeFrame: Baseline
measure: Liver fat content
timeFrame: Baseline
measure: Myocardial fatty acid uptake
timeFrame: Baseline
measure: Liver fatty acid uptake
timeFrame: Baseline
measure: Abdominal subcutaneous adipose tissue fatty acid uptake
timeFrame: Baseline
measure: Visceral adipose tissue fatty acid uptake
timeFrame: Baseline
measure: Brown adipose tissue fatty acid uptake at fasting state
timeFrame: Baseline
measure: Brown adipose tissue fatty acid uptake during cold exposure
timeFrame: Baseline
measure: Skeletal muscle fatty acid uptake
timeFrame: Baseline
measure: Coronary flow reserve
timeFrame: Baseline
Other outcomes:
Locations:
city: Turku
country: Finland
facility: Turku PET Centre (Turku University Hospital)
Study officials:
affiliation: Turku PET centre, TurkuUH
name: Pirjo R Nuutila, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: