louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03865823: Evaluation of the Recovery Rate and Postoperative Incontinence of Surgical Fistulas in a Cohort of a Reference Centre
Official title: Evaluation of the Recovery Rate and Postoperative Incontinence of Surgical Fistulas in a Cohort of a Reference Centre
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Anal Fistula
Keywords: anal fistula
anal infection
Lead sponsor: Groupe Hospitalier Diaconesses Croix Saint-Simon
Sponsor class: OTHER
First posted: 2019-03-07
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient with an anus fistula with indication for surgical treatment

Brief summary: Fistula is a pathology that can be complex and lead to treatment difficulties for the proctologist.

The proctologist's objective is to treat the infection (anal fistula and abscess) with the minimum impact on anal continence. Drainage of the fistula pathway(s) and removal of infected tissue during initial surgery are essential. The treatment of upper trans-sphincterial fistulas, i. e. those that span more than half the height of the anal sphincter, poses risks to anal continence. It sometimes requires several times of surgical treatment.

The study aim to investigate the fate of all patients treated for anal fistula in an expert team, in terms of impact on healing and anal continence and according to the type of anal fistula, the co-morbidity, the surgical techniques used and the bacterial flora responsible.


Eligibility criteria: Inclusion Criteria:

* Patient over the age of 18, patient with an anus fistula with indication for surgical treatment

Exclusion Criteria:

* Cutaneous Suppuration, without fistula (e.g., Verneuil disease, boil)

Primary outcomes:
measure: Identify the risk factors, including infectious, of failure of the surgery of the fistula in an expert center
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Groupe Hospitalier Diaconesses Croix Saint Simon
Study officials:
References:
Clinical trial NCT05600023: The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic Paste
Official title: The Effectiveness of Single Antibiotic Paste Nitrofurantoin V/S Double Antibiotic Paste in Alleviation of Post-Operative Pain in Adult Patients Symptomatic Irreversible Pulpitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Pain
Symptomatic Irreversible Pulpitis
Lead sponsor: Altamash Institute of Dental Medicine
Sponsor class: OTHER
First posted: 2022-10-31
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In our study, we used nitrofurantoin as a root canal medication in patients suffering from symptomatic irreversible pulpitis in alleviating pain compared with double antibiotic paste.

Detailed description: This study aims to compare the efficacy in alleviating pain between intracanal medicaments Nitrofurantoin versus double antibiotic paste.

Eligibility criteria: Inclusion Criteria:

* No medical history
* no history of allergy to medications used in root canal treatment
* patients suffering from Symptomatic Irreversible Pulpitis

Exclusion Criteria:

* Patients who were not suitable for conventional root canal treatment
* multirooted teeth

Primary outcomes:
measure: To alleviate dental pain
timeFrame: 12 hours upto 72 hours following placement of intracanal medicament
Secondary outcomes:
Other outcomes:
Locations:
city: Karachi
country: Pakistan
facility: Hira Danish
state: Sindh
Study officials:
References:
Clinical trial NCT02963623: Fibtem Predicts Postoperative Bleeding
Official title: The Prediction of Postoperative Hemorrahge Amount in Total Knee Replacement Using Fibtem
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Hemorrhage
Keywords: fibtem
total knee replacement
Lead sponsor: Konkuk University Medical Center
Sponsor class: OTHER
First posted: 2016-11-15
Enrollment: 54
Sex: ALL
Minimum age (years): 19
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: total knee replacement patients

Brief summary: Retrospective study to evaluate if FIBTEM predicts the amount of postoperative bleeding in total knee replacement patients.

Detailed description: This retrospective study evaluate patients who underwent total knee replacement arthroplasty. Laboratory coagulation parameters, including FIBTEM, before anesthesia induction and after admission to the post-anesthetic care unit and decrement of postoperative haemoglobin and amount of transfusion were reviewed.

A correlation coefficient of ρ = 0.4 was calculated from a pilot study. We need at least 44 subjects with an α value of 0.05 and a power of 0.8.

Eligibility criteria: Inclusion Criteria:

* patients who underwent primany unilateral total knee replacement arthroplasty under general anesthesia
* patients who had FIBTEM performed

Exclusion Criteria:

* surgery under regional anaesthesia
* a simultaneous bilateral total knee replacement arthroplasty
* the second surgery of staged total knee replacement arthroplasty
* revision of total knee replacement arthroplasty
* patients who received intraoperative transfusion
* patients who use tranexamic acid
* patients who received fibrinolytic agents because of perioperative thromboembolic event
* patients who refused transfusion because of religious belief of personal causes

Primary outcomes:
measure: haemoglobin
timeFrame: postoperative periods
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Ka Young Rhee
Study officials:
affiliation: Konkuk University Medical Center
name: Ka Young LRhee
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06074523: Psychometric Testing: Cued vs. Learned Suppression
Official title: Psychometric Testing: Cued vs. Learned Suppression
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: attention
Lead sponsor: Lehigh University
Sponsor class: OTHER
First posted: 2023-10-10
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Within-subjects measures, correlational analysis
Primary purpose: BASIC_SCIENCE

Brief summary: In this line of research, the researchers are examining whether performance on a cued attentional suppression (ignoring) task is related to performance on a learned attentional suppression task. In addition, these measures are related to the capacity of working memory and every day inattentive traits.

Detailed description: This is a behavioral study. The researchers will measures performance on multiple tasks. 1) a cued attentional suppression task, where participants are told the color of the item they are supposed to ignore on each trial. 2) a learned attentional suppression task, where participants learn over experience that a particular color is not the target. 3) a visual working memory capacity measurement 4) an inattentive trait report task, where participants report their experiences of inattention during their daily lives.

Eligibility criteria: Inclusion Criteria:

* Normal or corrected-to-normal visual acuity, normal color vision

Exclusion Criteria:

* age

Primary outcomes:
measure: Button Press Reaction Time
timeFrame: 1 day
measure: Learned Suppression Task
timeFrame: 1 day
measure: Visual Working Memory Capacity
timeFrame: 1 day
measure: Inattentive Traits Subscale of Adult Attention Deficit Hyperactivity Disorder (ADHD) Self Report Scale
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Bethlehem
country: United States
facility: Lehigh University
state: Pennsylvania
Study officials:
affiliation: Lehigh University
name: Nancy Carlisle, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Arita JT, Carlisle NB, Woodman GF. Templates for rejection: configuring attention to ignore task-irrelevant features. J Exp Psychol Hum Percept Perform. 2012 Jun;38(3):580-4. doi: 10.1037/a0027885. Epub 2012 Apr 2.
Clinical trial NCT03789123: Effects of Dienogest and Dienogest Plus Estradiol Valerate in Ovarian Endometrioma
Official title: Effects of Dienogest and Dienogest Plus Estradiol Valerate on Ovarian Reserve and Endometrioma Size
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Ovarian Reserve
Keywords: Endometrioma
Estradiol valerate + dienogest
Dienogest
Ovarian reserve
Lead sponsor: Bagcilar Training and Research Hospital
Sponsor class: OTHER_GOV
Collaborators: name: Kocaeli Derince Education and Research Hospital
name: Suleymaniye Birth And Women's Health Education And Research Hospital
First posted: 2018-12-28
Enrollment: 710
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Progesterone resistance in endometriosis is a known fact. The progestin derivatives used in endometriosis cause decidualization and atrophy of ectopic foci. Moreover, they inhibit neo-angiogenesis, provide suppress expansile/destructive growth facilitated by matrix metalloproteinases, and implantation of ectopic foci. The effect of drugs containing the estrogen-progesterone combination is mainly based on the inhibition of ovulation, decidualization and atrophy of ectopic foci. In estrogen-progesterone mechanism, it is known that estrogen has a progesterone receptor-enhancing effect, which may make progesterone more potent. Based on this, the investigators hypothesized that estrogen added to progesterone could lead to a further reduction in endometrioma size by various mechanisms which probably include the increased progesterone sensitivity in endometriosis. In addition, the investigators hypothesized that this therapy can alleviate the destructive effect of endometriomas on the ovarian reserve.


Eligibility criteria: Inclusion Criteria:

1. Study Group: At least one endometrioma greater than 3 cm, between 18-40 years of age, without surgical indication at the time of diagnosis, occasionally and intermittently controlled pain with NSAIDs or no pain symptom
2. Control Group: Patients with reproductive age without any ovarian cysts

Exclusion Criteria:

* suspicion of malignancy, irregular mentrual period, endocrine diseases, drug intake that may affect ovarian reserve in the last 6 months (i.e GnRH agonists), previous ovarian surgery, AMH levels under 2 ng/ml.

Primary outcomes:
measure: Ovarian reserve
timeFrame: up to 24 months
Secondary outcomes:
measure: Endometrioma Size
timeFrame: up to 24 months
measure: Pain Score
timeFrame: up to 24 months
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Tolga Karacan
state: Bagcilar
Study officials:
affiliation: Istanbul University Cerrahpasa Medical Faculty
name: Engin Oral, Prof.Dr. M.D
role: STUDY_DIRECTOR
References:
Clinical trial NCT05796323: Perceptions and Prevalence of Workplace Violence in Healthcare
Official title: Perceptions and Prevalence of Workplace Violence in Healthcare
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Violence
Lead sponsor: Methodist Health System
Sponsor class: OTHER
First posted: 2023-04-03
Enrollment: 3000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants must be employed full-time, part-time, or per diem (PRN) by the acute care organization (MDMC, MCMC, MMMC, MSMC, MLMC) at the time of study data collection. All staff, both clinical and non-clinical, are eligible to participate. Participants must be able to read English.

Brief summary: Workplace violence includes physical and verbal aggression as well as threatening behavior. All types of workplace violence incidents in health care are often under-reported, especially if there is no lasting physical injury.

Detailed description: Research reveals that healthcare workers are three times more likely to experience workplace violence than any other occupation. The first step toward reducing the occurrence of violence is to understand the perceptions and prevalence of workplace violence.

Eligibility criteria: Inclusion Criteria:

* Participants must be employed full-time, part-time, or per diem

Exclusion Criteria:

* Inability to read English will cause a staff member to be excluded from the study, as the survey is written in English.

Primary outcomes:
measure: Level and type of workplace violence
timeFrame: Period of 6 months
measure: Impact on the individual employee/worker
timeFrame: Period of 6 months
Secondary outcomes:
measure: Research Instruments Survey Questionnaire
timeFrame: Period of 6 months
measure: Self-reported impact of violence on quality of care for patients
timeFrame: Period of 6 months
Other outcomes:
Locations:
city: Dallas
country: United States
facility: Methodist Dallas Medical Center
state: Texas
Study officials:
affiliation: Methodist Health System
name: Laura Sweatt, MSN, RN-BC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00991523: Overnight Post-Exercise Recovery After Protein Ingestion Prior to Sleep
Official title: Protein Ingestion Prior to Sleep as a Dietary Strategy to Improve Post-exercise, Overnight Recovery.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Resistance Training
Keywords: resistance
exercise
protein
recovery
Lead sponsor: Maastricht University Medical Center
Sponsor class: OTHER
Collaborators: name: GlaxoSmithKline
First posted: 2009-10-08
Enrollment: 24
Sex: MALE
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to examine the effects of post-exercise protein ingestion prior to sleep on overnight protein kinetics and muscle recovery.


Eligibility criteria: Inclusion Criteria:

* Male
* Age between 20 and 30 years
* Healthy, recreationally active
* BMI \<25 kg/m2

Exclusion Criteria:

* Use of medication

Primary outcomes:
measure: muscle protein synthesis
timeFrame: 10 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Maastricht
country: Netherlands
facility: Maastricht MUMC
state: LI
city: Maastricht
country: Netherlands
facility: MaastrichtUMC
Study officials:
affiliation: Maastricht University Medical Center
name: Luc van Loon, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gorissen SHM, Trommelen J, Kouw IWK, Holwerda AM, Pennings B, Groen BBL, Wall BT, Churchward-Venne TA, Horstman AMH, Koopman R, Burd NA, Fuchs CJ, Dirks ML, Res PT, Senden JMG, Steijns JMJM, de Groot LCPGM, Verdijk LB, van Loon LJC. Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans. J Nutr. 2020 Aug 1;150(8):2041-2050. doi: 10.1093/jn/nxaa024.
citation: Res PT, Groen B, Pennings B, Beelen M, Wallis GA, Gijsen AP, Senden JM, VAN Loon LJ. Protein ingestion before sleep improves postexercise overnight recovery. Med Sci Sports Exerc. 2012 Aug;44(8):1560-9. doi: 10.1249/MSS.0b013e31824cc363.
Clinical trial NCT05912023: Perioperative Vaping Complications
Official title: Vaping Associated Perioperative Pulmonary Complications - Anesthetic Implications
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Vaping
Complication of Anesthesia
Keywords: Vaping
Hypoxemia
Bronchospasm
Perioperative
Pneumonitis
Lead sponsor: Navy Medical Center San Diego
Sponsor class: FED
First posted: 2023-06-22
Enrollment: 300
Sex: ALL
Minimum age (years): 12
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients, both those that vape and those that do not, who meet the inclusion criteria and receive general anesthesia to facilitate surgical intervention at Naval Medical Center San Diego.

Brief summary: Prospective observational study evaluating the incidence, and qualifying the types, of perioperative pulmonary complications in patients that vape.

Detailed description: The primary objective of our study is to determine the rate at which patients that vape or use e-cigarettes experience perioperative pulmonary complications during and following general anesthesia. Complications of interest will include postoperative atelectasis with hypoxemia necessitating oxygen therapy, pneumothorax, pneumonia, bronchospasm, bronchospasm requiring bronchodilator therapy, exacerbation of underlying pulmonary disease, pneumonia, ARDS, and acute respiratory failure. Hospital course, including prolonged PACU stay, prolonged hospital admission for inpatients, and rate of ICU admissions, will also be investigated.

A secondary objective will be to further investigate and include the relationship between vaping cessation timeline in the preoperative period and the occurrence of PPCs, which is similarly underreported in the literature. Furthermore, the study will assess how effectively anesthesia providers are screening for vaping or e-cigarette use as part of the preoperative evaluation, given that "it is unclear whether anesthesiologists and surgeons routinely ask patients explicitly about vaping" in the pre-operative setting. This lack of representative screening for vaping further obscures an understanding of the relationship between vaping, vaping cessation, and PPCs.

Eligibility criteria: Inclusion Criteria:

* Surgical Patient
* General Anesthesia
* Hx of vaping
* Age ≥12

Exclusion Criteria:

* Age \<12
* Pregnancy
* Active preoperative pulmonary infection
* Recent pulmonary infection (within 8 weeks)
* Active tobacco smoker
* Poorly controlled reactive airway disease (requires more than PRN albuterol)
* Non-Lung Protective Ventilation

Primary outcomes:
measure: Perioperative pulmonary complications
timeFrame: From the initiation of general anesthesia through postoperative day seven.
Secondary outcomes:
measure: Vaping cessation timeline
timeFrame: From the initiation of general anesthesia through postoperative day seven.
Other outcomes:
Locations:
city: San Diego
country: United States
facility: Naval Medical Center San Diego
state: California
Study officials:
References:
Clinical trial NCT05949723: Development of Artificial Intelligence Golf Training Simulator
Official title: Development of Artificial Intelligence Golf Training Simulator: Integration of Inertial Sensing Device and Musculoskeletal Simulation Model for Movement Feedback System
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Musculoskeletal Model
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2023-07-18
Enrollment: 12
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The golf simulator can accurately predict the flight trajectory and landing point of the ball using high-speed moving object measurement technology, giving the user the impression that they are playing on a real golf course.

Detailed description: The golf simulator can accurately predict the flight trajectory and landing point of the ball using high-speed moving object measurement technology, giving the user the impression that they are playing on a real golf course. This project will integrate golf simulators, swing analysis, and musculoskeletal simulation systems; digitize human movements; calculate biomechanical parameters; and assist beginners in swing learning or professional golfer training.

Eligibility criteria: Inclusion Criteria:

* Healthy golf players and more than 3 years of golf experience
* Age between 20\~60 years old

Exclusion Criteria:

* Musculoskeletal disease within 6 months

Primary outcomes:
measure: Kinematics data_range of motion
timeFrame: 6 months
measure: Kinematics data_displacement of center of mass
timeFrame: 6 months
measure: Kinetic data_mean velocity
timeFrame: 6 months
measure: Kinetic data_mean distance
timeFrame: 6 months
measure: Kinetic data_mean frequency
timeFrame: 6 months
measure: Kinetic data_95% confidence ellipse area
timeFrame: 6 months
measure: Kinematics data by inertial measurement units_linear acceleration
timeFrame: 6 months
measure: Kinematics data by inertial measurement units_angular velocity
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University
Study officials:
References:
Clinical trial NCT02203123: Ratio of Inferior Vena Cava and Aorta Diameter in Dehydrated Children
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Dehydration
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2014-07-29
Enrollment: 226
Sex: ALL
Minimum age (years): 3
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: * There is no definite tool for measurement of dehydration in children
* Subjective clinical dehydration scale is considered as valuable scoring system, but it cannot be reliable among clinicians sometimes.
* Some authors found Inferior vena cava/Aorta ratio can be a objective marker for dehydration
* However, there is no evidence of correlation between clinical dehydration scale and inferior vena cava/aorta ratio
* We will observe correlation between clinical dehydration scale and inferior vena cava/aorta ratio and change of the ratio according to hydration with intravenous normal saline infusion.


Eligibility criteria: Inclusion Criteria:

* All children with dehydration who visit emergency department

Exclusion Criteria:

* congenital heart disease
* bronchopulmonary dysplasia
* renal disease
* liver disease

Primary outcomes:
measure: diameter of inferior vena cava and aorta
timeFrame: up to 2 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Gumi-dong, Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
Study officials:
affiliation: Seoul National University Bundang Hospital
name: Jin Hee Lee, Professor
role: PRINCIPAL_INVESTIGATOR
References: