Clinical trial NCT05845190: Effect of Aerobic Training Versus Resistance Training on Plasma Homocystiene in Diabetic Patients
Official title: Effect of Aerobic Training Versus Resistance Training on Plasma Homocystiene in Diabetic Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Diabete Type 2
Lead sponsor: Egyptian Chinese University
Sponsor class: OTHER
First posted: 2023-05-06
Enrollment: 60
Sex: MALE
Minimum age (years): 40
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: simple randomization using a randomization table created by a computer software program
Primary purpose: OTHER

Brief summary: The goal of this \[clinical trial\] is to \[ compare \] in \[ diabetic male patients \]. The main question to answer is :

Will be any difference between aerobic exercises and resistance exercises in improving levels of homocysteine, cholesterol and insulin in diabetic patients?

Participants will take their medications and group of them do aerobic exercises and another group do resistance training

Detailed description: 40 male diabetic patients diagnosed by type 2 diabetes mellites to evaluate therapeutics outcomes of aerobic exercises versus resistance exercises as a treatment tool on homocysteine, insulin and cholesterol levels in diabetic patients.

The patients will be randomly assigned to two equal (in number) groups:

Group (A) Twenty male patients will receive moderate intensity aerobic exercises in a form of supervised treadmill walking for 30-45 mins performed 3 times/ week for 12 weeks.

Group (B) Twenty male patients will receive resistance training program comprised 30-45 min performed 3 times /week for 12 weeks.

Eligibility criteria: Inclusion Criteria:

* 1- Their ages will range from 40 -55 years 2- Their body mass indexes will range between (25 to 35 Kg / m²). 3-All patients are diagnosed with type 2 diabetes mellites.
* Diagnostic criteria for type 2 diabetes were: 1) a fasting plasma glucose concentration of 7.0 mmol·L-1 or higher or 2) a plasma glucose concentration of 11.1 mmol·L-1 or higher two hours after an oral glucose challenge. (Punthakee et al.,2018).
* All subjects took oral hypoglycemic drugs but none of them were being treated with insulin when enrolled.

  4- All patients are medically and psychologically stable

Exclusion Criteria:

1. Patients with uncontrolled blood glucose level
2. Patients with unstable cardiovascular conditions (those with a known history of uncontrolled hypertension, ischemic attacks, stroke, congestive heart failure, currently on anticoagulation therapy) were excluded from this study.
3. Patients with severe pulmonary disease (with restrictive lung disease or with obstructive lung disease).
4. Patients with musculoskeletal disorders (Diagnosed with severe osteoporosis or severe osteoarthritis).
5. Patients with BMI \> 35 will be excluded from the study.

Primary outcomes:
measure: homocystiene
timeFrame: 12 weeks of training
Secondary outcomes:
measure: insulin
timeFrame: 12 weeks of training
measure: cholestrol
timeFrame: 12 weeks of trianing
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Egyptian Chineese University
state: Gesr Elsuez
Study officials:
affiliation: Egyptian Chinese University
name: hanan hassan
role: PRINCIPAL_INVESTIGATOR
References: