louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06602401: Investigation of Functional Parameters
Official title: Investigation of Functional Parameters: Relationships Between Bimanual Coordination, Proprioception, Manuel Dexterity, and Strength
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Grip
Pinch
Strength
Wrist
Dexterity
Lead sponsor: Gazi University
Sponsor class: OTHER
Collaborators: name: Ali ZORLULAR
name: Tuğçe ÇOBAN
name: Ahmet GÖKKURT
name: Zeynep EMİR
name: Nevin ATALAY GÜZEL
name: Deran OSKAY
First posted: 2024-09-19
Enrollment: 25
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: No specific age or disease/injury group is targeted. The study was conducted with healthy volunteers.

Brief summary: The goal of this cross-sectional study is to investigate the relationships between grip/pinch strengths, wrist flexion-extension strengths, wrist proprioception, manual dexterity, and bimanual coordination in healthy volunteers. The hypotheses are:

H0: There is no relationship between grip/pinch strengths, wrist flexion-extension strengths, wrist proprioception, manual dexterity, and bimanual coordination.

H1: There is a relationship between grip/pinch strengths, wrist flexion-extension strengths, wrist proprioception, manual dexterity, and bimanual coordination.

Within the scope of the study, the participants' active joint position sense (AJPS) and flexion-extension strengths of the wrist were assessed using an isokinetic dynamometer. Additionally, grip strength, key pinch, tip pinch, and palmar pinch strengths were evaluated using a dynamometer. The Purdue Pegboard Test was used to assess manual dexterity and bimanual coordination.


Eligibility criteria: Inclusion Criteria:

After providing detailed information about the research, individuals who agreed to participate were included in the study.

Exclusion Criteria:

Individuals who had undergone surgery or trauma in the upper extremity, had fractures or acute orthopedic injuries, had a history of neuromuscular diseases or congenital anomalies, had skin infections, or other conditions that could affect the assessment within the past 6 months were excluded from the study.

Primary outcomes:
measure: The Purdue Pegboard Test was used to assess bimanual coordination.
timeFrame: Participants will be evaluated only once.
measure: The Purdue Pegboard Test was used to assess manual dexterity.
timeFrame: Participants will be evaluated only once.
measure: The active joint position sense was assessed using an isokinetic dynamometer.
timeFrame: Participants will be evaluated only once.
measure: The flexion-extension strengths of the wrist were assessed using an isokinetic dynamometer.
timeFrame: Participants will be evaluated only once.
measure: Grip and pinch strengths were measured using a digital dynamometer.
timeFrame: Participants will be evaluated only once.
Secondary outcomes:
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: Barış SEVEN
state: Çiğli
Study officials:
References:
Clinical trial NCT03338101: Comparative Study Between Tonometers
Official title: Comparative Study Between the Goldmann Flattening Tonometer and the Non-Contact Tonometer in Patients of a Reference Ophthalmological Hospital
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Glaucoma Eye
Lead sponsor: Instituto de Olhos de Goiania
Sponsor class: OTHER
First posted: 2017-11-09
Enrollment: 100
Sex: ALL
Minimum age (years): 1
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients with glaucoma diagnosed who are monitorated in the hospital

Brief summary: Comparative study between the Goldmann Flattening Tonometer and the Non-Contact Tonometer in patients of a Reference Ophthalmological Hospital


Eligibility criteria: Inclusion Criteria:Pacients with glaucoma diagnosed -

Exclusion Criteria:Pacients without glaucoma diagnosed

-

Primary outcomes:
measure: Comparative study between the Goldmann Flattening Tonometer and the Non-Contact Tonometer in patients of a Reference Ophthalmological Hospital
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Goiânia
country: Brazil
facility: Instituto de Olhos de Goiania
state: Goias
Study officials:
References:
Clinical trial NCT00414401: Clinical Reminders in Test Reports to Improve Guideline Compliance
Official title: Clinical Reminders in Test Reports to Improve Guideline Compliance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Failure, Congestive
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2006-12-21
Enrollment: 1500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Although beta-blockers are known to prolong survival for patients with reduced left ventricular ejection fraction, their use in the community and the VA is suboptimal.

Detailed description: Background:

Although beta-blockers are known to prolong survival for patients with reduced left ventricular ejection fraction, their use in the community and the VA is suboptimal.

Objectives:

To determine if a reminder attached to the echocardiography report would increase the use of beta-blockers among patients with depressed left ventricular function.

Methods:

We are randomizing consecutive patients undergoing echocardiography at one of three VA echocardiography laboratories with reduced left ventricular ejection fraction (\<40%) and no echocardiographic contraindication to beta-blockers (e.g. aortic stenosis) to a reminder for use of beta-blockers or to no reminder. The reminder gives starting doses for two commonly used beta-blockers (carvedilol and metoprolol). Patients are excluded from the analysis if they leave the health care system or die within three months of randomization. The primary outcome is a prescription for a beta-blocker between three and nine months following echocardiography

Status:

The project is complete.

Eligibility criteria: Inclusion Criteria:

Those undergoing echocardiography at one of the participating laboratories with an ejection fraction \< 45%.

Exclusion Criteria:

aortic stenosis, mitral stenosis

Primary outcomes:
measure: Prescription for any beta-blocker
Secondary outcomes:
measure: Prescription for carvedilol or metoprolol succinate
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: VA Palo Alto Health Care System, Palo Alto, CA
state: California
Study officials:
affiliation: VA Palo Alto Health Care System, Palo Alto, CA
name: Paul A. Heidenreich, MD MS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Heidenreich PA, Gholami P, Sahay A, Massie B, Goldstein MK. Clinical reminders attached to echocardiography reports of patients with reduced left ventricular ejection fraction increase use of beta-blockers: a randomized trial. Circulation. 2007 Jun 5;115(22):2829-34. doi: 10.1161/CIRCULATIONAHA.106.684753. Epub 2007 May 21.
citation: Heidenreich PA, Chacko M, Goldstein MK, Atwood JE. ACE inhibitor reminders attached to echocardiography reports of patients with reduced left ventricular ejection fraction. Am J Med. 2005 Sep;118(9):1034-7. doi: 10.1016/j.amjmed.2004.12.028. No abstract available.
Clinical trial NCT03618901: Rock Steady Boxing vs. Sensory Attention Focused Exercise
Official title: A Randomized Crossover Trial: The Effects of Rock Steady Boxing vs. Sensory Attention Focused Exercise on Disease Progression for Those With Parkinson's Disease.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Parkinson Disease
Lead sponsor: Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Sponsor class: OTHER
First posted: 2018-08-07
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The early start group: 12-weeks (intervention) followed by 12-weeks of no exercise.

The delayed start group: 12-weeks (no exercise) followed by 12-weeks (intervention).

This model will be used for both RSB and PD SAFEx.
Primary purpose: OTHER

Brief summary: This study evaluates the effect on Rock Steady Boxing (RSB) and PD SAFEx on Parkinson's disease.

Detailed description: Both interventions produce benefits to the PD population. PD SAFEx has been proven to improve the motor symptoms of PD. However, research still needs to be conducted on the PD specific benefits associated with RSB. As such it an RCT is necessary to compare the effects of both interventions.

Eligibility criteria: Inclusion Criteria:

* must be able to understand verbal instructions in English
* diagnosed with idiopathic PD by a neurologist

Exclusion Criteria:

* if diagnosed with a neurological condition other than PD
* if participated in an exercise program at least 2-weeks prior to the start of the study

Primary outcomes:
measure: Motor symptom improvements
timeFrame: change from baseline at 12 weeks
Secondary outcomes:
measure: Quality of life assessments
timeFrame: change from baseline at 12 weeks
measure: Balance1
timeFrame: change from baseline at 12 weeks
measure: Gait1
timeFrame: change from baseline at 12 weeks
measure: Strength
timeFrame: change from baseline at 12 weeks
measure: Cognitive Assessment 1
timeFrame: change from baseline at 12 weeks
measure: cognitive assessment 3
timeFrame: change from baseline at 12 weeks
measure: Balance 2
timeFrame: change from baseline at 12 weeks
measure: Cognitive assessment 2
timeFrame: change from baseline at 12 weeks
Other outcomes:
measure: Balance3
timeFrame: change from baseline at 12 weeks
measure: Physical activity
timeFrame: change from baseline at 12 weeks
measure: Gait 2
timeFrame: change from baseline at 12 weeks
Locations:
city: Waterloo
country: Canada
facility: Movement Disorders Research and Rehabilitation Centre
state: Ontario
Study officials:
References:
Clinical trial NCT03930901: Impact of Health Education Learning Package Against Intestinal Parasitic Infections Among Orang Asli Children
Official title: Impact of Health Education Learning Package Against Intestinal Parasitic Infections Among Orang Asli Schoolchildren in Malaysia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intestinal Parasitic Infections
Knowledge, Attitudes, Practice
Keywords: Intestinal Parasitic Infections
Soil-transmitted helminth infections
Health education
Lead sponsor: University of Malaya
Sponsor class: OTHER
First posted: 2019-04-29
Enrollment: 1142
Sex: ALL
Minimum age (years): 8
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two groups; intervention group that involved schools where HELP will be administered and control group that involved schools that will not receive health education.
Primary purpose: PREVENTION

Brief summary: A health education learning package (HELP) has been improved and evaluated for its impact against intestinal parasitic infections among Orang Asli schoolchildren in West Malaysia. 13 schools were allocated into two groups (intervention and control groups) and the impact of HELP was evaluated after 3 and 6 months of baseline assessment and HELP intervention.

Detailed description: This study was conducted to evaluate the impact of an improved health education learning package (HELP) against intestinal parasitic infections among Orang Asli schoolchildren in West Malaysia. The package has been tested by a pilot study in 2013 among children in 2 schools in Pahang state.

In the current study, HELP package has been improved and children from 13 primary schools in 11 districts of six states in Peninsular Malaysia were allocated into two groups (intervention and control groups) and the impact of HELP was evaluated after 3 and 6 months of baseline assessment and HELP intervention.

The evaluation involved soil-transmitted helminth infections and intestinal protozoa infections.

Eligibility criteria: Inclusion Criteria:

* Grade 2 - 6
* Orang Asli ethnicity
* Schools exclusively for Orang Asli

Exclusion Criteria:

* Grade 1
* Chronic sever diseases
* no consent
* schools for mixed population groups

Primary outcomes:
measure: Re-infection rate of intestinal parasitic infections using multiple parasitological and molecular diagnostic techniques
timeFrame: 6 months
Secondary outcomes:
measure: Intensity rate of intestinal parasitic infections using multiple parasitological and molecular diagnostic techniques
timeFrame: 6 months
Other outcomes:
Locations:
city: Kuala Lumpur
country: Malaysia
facility: University of Malaya
Study officials:
affiliation: University of Malaya
name: Hesham M Al-Mekhlafi, PhD
role: STUDY_DIRECTOR
References:
citation: Al-Delaimy AK, Al-Mekhlafi HM, Lim YA, Nasr NA, Sady H, Atroosh WM, Mahmud R. Developing and evaluating health education learning package (HELP) to control soil-transmitted helminth infections among Orang Asli children in Malaysia. Parasit Vectors. 2014 Sep 2;7:416. doi: 10.1186/1756-3305-7-416.
Clinical trial NCT01871701: Clinical Trial to Investigate the Effect on Corrected QT Interval Prolongation by Psychotropic Drugs
Official title: Clinical Trial to Investigate the Effect on Corrected QT Interval Prolongation by Psychotropic Drugs in Healthy Korean Adults After a Single Oral Administration of Escitalopram, Quetiapine, and Moxifloxacin
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Keywords: Corrected QT interval prolongation
Psychotropic drugs
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: Seoul National University Bundang Hospital
First posted: 2013-06-07
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: To evaluate the corrected QT interval change(automatic-reading) after single oral administration of escitalopram, quetiapine and moxifloxacin versus placebo in healthy Korean Adults.

Detailed description: Randomized, Open-label, Placebo-controlled, 4-way crossover study

Eligibility criteria: Inclusion Criteria:

1. Healthy subjects aged 20 - 40 years.
2. A body weight in the range of 50 kg (inclusive) - 90 kg (inclusive) and a body mass index (BMI) in the range 19.0 kg/m2 (inclusive) - 25.0 kg/m2 (inclusive).
3. Sufficient ability to understand the nature of the study and any hazards of participating in it. Provide written informed consent after being fully. informed about the study procedures.

Exclusion Criteria:

1. Presence or history of hypersensitivity or allergic reactions to drugs including investigational product (Escitalopram, Quetiapine, Moxifloxacin)) or other quinolone group antibiotics.
2. Subject judged not eligible for study participation by investigator.

Primary outcomes:
measure: Corrected QT interval prolongation
timeFrame: Predose (3 times) and 1, 2, 3, 4, 6, 8, 12, 16, 24 h, additional 26, 28, 32, 48 h after escitalopram dosing
Secondary outcomes:
measure: AUC (area under the plasma concentration-time curve) of escitalopram
timeFrame: Predose and 1, 2, 3, 4, 6, 8, 12, 16, 24, 30, 36, 48h postdose
measure: AUC (area under the plasma concentration-time curve)of quetiapine, moxifloxacin
timeFrame: Predose and 1, 2, 3, 4, 6, 8, 12, 16, 24 h postdose
Other outcomes:
Locations:
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyounggi
Study officials:
affiliation: Department of Clinical Pharmacology and Therapeutics, Seoul National University Bundang Hospital, Seongnam, Korea
name: Jae-Yong Chung, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01351701: Bacteriological Study of Diabetic Foot and Antibiotic Sensitivity Pattern in Eastern India
Official title: An Observational, Prospective, Multicentre Study in Eastern India to Understand the Bacteriological Epidemiology in Diabetic Foot and Sensitivity Pattern of Antibiotics Along With the Pattern of Empirical Therapy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Diabetic Foot
Keywords: Diabetic foot
Bacteriological epidemiology
Wagner's Grading
eastern India
Lead sponsor: Sun Valley Hospital, Guwahati
Sponsor class: OTHER
First posted: 2011-05-11
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Mixed-Rural/Urban in three eastern states of India

Brief summary: The pattern of organism causing diabetic foot infection are presumed to vary from location to location depending on the antibiotic prescription practice, geographical locations, environmental variations and therapeutic interventions for various patients. Our hypothesis is look to finding out common similarities with diversified subgroups spread across various geographical locations of eastern part of India, thus to create a data base for treating patient with diabetic foot infections.The sensitivity pattern is anticipated to be different from institution to institutions and place to place but the gross sensitivity data of local pathogen could guide physician for choosing right empirical antibiotic. Practice guideline could be postulated from the collated data of distribution of pathogens, their sensitivity pattern as well as co-morbid conditions of the sufferers.


Eligibility criteria: Inclusion Criteria:

* diabetic foot patients with Wagner's grade 2 or more foot infection.

Primary outcomes:
measure: Epidemiological pattern of diabetic foot infection in eastern India
timeFrame: One year
measure: Sensitivity of isolated organisms to antibiotics
timeFrame: one year
measure: Risk factors associated with different grades of severity of DFI
timeFrame: one year
Secondary outcomes:
measure: To record prevailing management practices of diabetic foot infection in terms of disease, antibiotic practice, practice of supportive and surgical care.
timeFrame: one year
measure: Common empiric antibiotic therapies used in management of DFI
timeFrame: one year
measure: Percentage sensitivity to different empiric antibiotics
timeFrame: one year
Other outcomes:
Locations:
city: Guwahati
country: India
facility: Sun Valley Diabetic Care And Research Centre
state: Assam
Study officials:
affiliation: Sun Valley Diabetic Care and Research Centre
name: DR SUDHIR Kr JAIN, MS (Surgery)
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04903301: Patient Satisfaction With Contoura Vision Topography-Guided LASIK
Official title: Patient Satisfaction With Contoura Vision Topography-Guided LASIK
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myopia
Astigmatism
Lead sponsor: Rush Eye Associates
Sponsor class: OTHER
First posted: 2021-05-26
Enrollment: 50
Sex: ALL
Minimum age (years): 21
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To evaluate patient reported outcomes associated with quality of vision before and after treatment with Contoura Vision Topography-Guided LASIK.


Eligibility criteria: Eligibility criteria: The study enrollment will include all willing patients with: pre-operative BCVA 20/20 for each eye individually, myopic refractive error up to -8.00 diopters, refractive astigmatism that ranges from 0 to 3 diopters, maximum spherical equivalent of -9.00 diopters, the designated age requirements, and only patients that have signed the informed consent document.

Exclusion criteria: Patients are excluded that are not willing to participate in a research trial, are unable to cooperate well enough to safely perform the procedure, fail to meet inclusion criteria, have ocular disease (including but not limited to keratoconus, macular degeneration, glaucoma, corneal dystrophy, dry eye syndrome and corneal scarring), and patients that have had previous ocular surgery. Any patients with known allergies to the post-operative medications or preservatives in the medications will also be excluded.

Primary outcomes:
measure: Global Vision Satisfaction Index
timeFrame: 26 weeks
Secondary outcomes:
measure: Vision
timeFrame: 26 weeks
measure: Objective Scatter Index
timeFrame: 26 weeks
measure: Higher Order Corneal Aberrations
timeFrame: 26 weeks
Other outcomes:
Locations:
city: Amarillo
country: United States
facility: Rush Eye Associates
state: Texas
Study officials:
References:
Clinical trial NCT02797301: A Computerised Test for Assessing the Early Reading Skills
Official title: A Computerised Test for Assessing the Early Reading Skills of Children With Mobility Limitations
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Learning Disorders
Keywords: early reading skills
Lead sponsor: University of Mogi das Cruzes
Sponsor class: OTHER
First posted: 2016-06-13
Enrollment: 40
Minimum age (years): 4
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: This study was to develop a computerised test with an adapted peripheral to assess the emerging literacy knowledge of children with mobility difficulties. The software was implemented using a game-like design controllable by a peripheral device without needing fine movements.

Detailed description: Conventional tests for assessing the early reading skills of preschool children on school entry are not accessible to children with mobility limitations. This paper presents a game-like computerised test featuring an appealing scenario that is accessible to these children. It was developed on a platform that creates 2D vector graphics and contains three phases of interactive content accessible through an adapted peripheral. Conventional tests were also used to validate the effectiveness of the game. The two types of tests had the same degree of predictive power when completed by thirty three preschool children without mobility impairment.

Eligibility criteria: Inclusion Criteria:

* G1 and G2: preschool children; no motor difficulties and normal school performance.
* G3: with moderate mobility impairment; similar cognitive ages and notions of writing to the participants of groups G1 and G2; children between seven and seventeen years old.

Exclusion Criteria:

* G1 and G2: children who often miss classes; children between four and seven years.
* G3: no moderate mobility impairment

Primary outcomes:
measure: Reading skills
timeFrame: 2 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of Mogi das Cruzes
name: Annie F. Frère, PhD
role: PRINCIPAL_INVESTIGATOR
References: