Clinical trial NCT02529046: Conjugated Linoleic Acid in Obese Women
Official title: Effect of Conjugated Linoleic Acid Associated With Aerobic Exercise on Body Fat and Lipid Profile in Obese Women: A Randomized, Double-blinded and Placebo-controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lipid Metabolism Disorders
Obesity
Lead sponsor: Universidade Estadual de Londrina
Sponsor class: OTHER
First posted: 2015-08-19
Enrollment: 28
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this trial, the investigators analyzed the effects of eight weeks of CLA supplementation associated with aerobic exercise on body fat and lipid profile in obese women.

Detailed description: The aim of this investigation was to analyze the effects of eight weeks of CLA supplementation associated with aerobic exercise on body fat and lipid profile in obese women. The investigators performed a randomized, double-blinded and placebo-controlled trial with 28 obese women who received 3.2 g/d of CLA or 4 g/d of olive oil (placebo group) while performing an 8-week protocol of aerobic exercise. Dietary intake (food record), body fat (DXA) and biochemical analysis (blood sample) were assessed before and after the intervention period.

Eligibility criteria: Inclusion Criteria:

* Had no signs or symptoms of disease
* No orthopedic injuries
* Must be inactive or moderately active (defined as performing any type of physical exercise less than twice a week)
* Must be non-smokers
* Must be free from the use of ergogenic aids
* Had no metabolic disorders or chronic degenerative diseases
* Not use drug therapy for body mass loss.

Exclusion Criteria:

* Had frequency to training sessions below 85% of the total sessions

Primary outcomes:
measure: Body fat
timeFrame: 8 weeks
Secondary outcomes:
measure: Total cholesterol
timeFrame: 8 weeks
measure: Triglycerides
timeFrame: 8 weeks
measure: High-density lipoprotein
timeFrame: 8 weeks
measure: Low-density lipoprotein
timeFrame: 8 weeks
measure: Trunk fat
timeFrame: 8 weeks
measure: Arm fat
timeFrame: 8 weeks
measure: Leg fat
timeFrame: 8 weeks
Other outcomes:
measure: Body mass
timeFrame: 8 weeks
measure: Maximum oxygen uptake
timeFrame: 8 weeks
Locations:
city: Londrina
country: Brazil
facility: Universidade Estadual de Londrina
state: Paraná
Study officials:
affiliation: Universidade Estadual de Londrina
name: Edilson Cyrino, PhD
role: STUDY_CHAIR
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