Clinical trial NCT04016350: Impact of Exercise Combined With Inulin Propionate Ester on Fat Oxidation
Official title: Impact of Moderate Intensity Exercise Training Combined With Inulin Propionate Ester Supplementation on Whole Body Resting Fat Oxidation and Body Weigh in Overweight Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Inulin Propionate Ester
Keywords: Exercise,
Inulin Propionate Ester
Gut hormones
Body weigh
Fat oxidation
Overweight women
Lead sponsor: University of Glasgow
Sponsor class: OTHER
First posted: 2019-07-11
Enrollment: 20
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This is a randomised study with parallel design. Study participants underwent 4 week supervised moderate intensity exercise training combined either with IPE or cellulose as placebo supplementation at doses of 10g/day. Measurements were done before and after intervention
Primary purpose: BASIC_SCIENCE

Brief summary: There is evidence to suggest that responsiveness to exercise training programmes can be expected to be influenced by changes in resting fat oxidation, an important factor in the aetiology of obesity. Our previous work has shown that oral supplementation with inulin propionate ester (IPE) reduces intra-abdominal fat and prevents weight gain and that oral propionate intake enhances resting fat oxidation. The effects of IPE combined with exercise training on resting fat oxidation and body fatness are unknown. The aim of this study was to investigate the impact of 4-weeks IPE supplementation, in combination with a moderate intensity exercise training programme, on whole body fat oxidation and on plasma GLP-1 and PYY.

Detailed description: Participants: Healthy overweight females with BMI \>25 kg/m2 and 25-45 years of age were recruited through advertisements and word of mouth on the campus of the University of Glasgow or from other public places. Participants were required to be sedentary, non-smokers, with stable body weight for two months prior to the study enrollment, not pregnant, free of medication, nutritional supplementation or following any specific diet and with no antibiotic use for the past three months. Participants with chronic illness, eating disorders and history of gastrointestinal operations were excluded.

Study Design: This is a randomized study with a parallel design. Study participants underwent 4 week supervised moderate intensity exercise training combined either with IPE (EX/IPE) or cellulose as placebo (EX/Placebo) supplementation at doses of 10g / day. Supplements were provided as sachets containing white powder and participants were asked to consume one sachet per day with breakfast in a way convenient for each participant. Before the start of the study and at the end of the 4-week intervention, participants were asked to conduct a submaximal exercise test. Prior to the first and after the second submaximal exercise test, participants of both groups conducted a 7-hour experimental trial which involved collection of expired air and blood samples in fasted and postprandial states. Body weight and body composition were measured in the fasted state. Prior to the first 7-hour experimental trial, participants were asked to record their diet for 3 days and replicate this intake prior to the second 7-hour experimental trial.

Eligibility criteria: Inclusion Criteria:

Healthy, sedentary and overweight females with BMI \>25 kg/m2 and stable body weight for two months prior to the study.

Exclusion Criteria:

Acute or chronic illness, eating disorders, history of gastrointestinal operations, smoking, pregnancy, taking supplements, and being on specific diet for the past three months.

Primary outcomes:
measure: Resting fat oxidation
timeFrame: 4 weeks
measure: Resting carbohydrate oxidation
timeFrame: 4 weeks
measure: Metabolic rate
timeFrame: 4 weeks
Secondary outcomes:
measure: Body weight
timeFrame: 4 weeks
measure: Body fat (%)
timeFrame: 4 weeks
measure: Maximal oxygen consumption [Time Frame: 4 weeks]
timeFrame: 4 weeks
measure: Peptide YY (PYY)
timeFrame: 4 weeks
measure: Glucagon-like peptide-1 (GLP-1)
timeFrame: 4 weeks
measure: Height
timeFrame: 4 weeks
Other outcomes:
Locations:
Study officials:
affiliation: University of Glasgow
name: Douglas Morrison, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Malkova D, Polyviou T, Rizou E, Gerasimidis K, Chambers ES, Preston T, Tedford MC, Frost G, Morrison DJ. Moderate intensity exercise training combined with inulin-propionate ester supplementation increases whole body resting fat oxidation in overweight women. Metabolism. 2020 Mar;104:154043. doi: 10.1016/j.metabol.2019.154043. Epub 2019 Nov 29.