Clinical trial NCT05494203: Multi-omics Study and Drug Intervention Study of Spondyloarthritis
Official title: Multi-omics Study and Drug Intervention Study of Spondyloarthritis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Spondylarthritis
Lead sponsor: First Affiliated Hospital of Wenzhou Medical University
Sponsor class: OTHER
First posted: 2022-08-09
Enrollment: 400
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: community sample

Brief summary: Spondyloarthritis (SpA) is a type of chronic inflammatory rheumatic disease that mainly affects the spine and peripheral joints, or joints, ligaments and tendons. This disease subtype has the same clinical and immunological features. Further explore the pathogenesis of spondyloarthritis, explore the guiding significance of different imaging examinations for spondyloarthritis, and study the efficacy and mechanism of different drugs for spondyloarthritis.

Detailed description: 1. Clinical phenotype research. The clinical phenotype is the symptoms and signs of the disease and its evolution. Through the clinical phenotype research of spondyloarthritis, it is helpful to realize the diagnosis and grading of spondyloarthritis and help to achieve individualization Precise treatment.
2. Transcriptomic research. The key genes and pathways involved in the pathogenesis of spondyloarthritis can be explored through transcriptomic research of spondyloarthritis, which can provide help for early diagnosis and seeking potential treatment methods.
3. Microbiological research. Through the microbiome research on spondyloarthritis, the composition and function of intestinal flora in patients with spondyloarthritis can be deeply analyzed to provide help for diagnosis and treatment.
4. Radiomics research. Through the radiomics research on spondyloarthritis, it is helpful to realize the diagnosis and grading of spondyloarthritis and the evaluation and prediction of treatment.
5. Drug treatment research By studying the therapeutic effects of different drugs in patients with spondyloarthritis, it is helpful to explore the efficacy and mechanism of different drugs on spondyloarthritis, and to achieve precise and individualized treatment.

Eligibility criteria: Inclusion Criteria:

* The patient meets the revised AS New York diagnostic criteria or ASAS axial SpA classification criteria.

Exclusion Criteria:

* patients with rheumatoid arthritis, scleroderma, systemic lupus erythematosus and other immune system diseases;
* patients who had received head and neck radiotherapy;
* patients with history of antidepressants and parasympathetic stimulants;
* patients known to be infected with human immunodeficiency virus (HIV) or hepatitis C virus;
* patients with sarcoidosis or tuberculosis infection.
* patients with inflammatory bowel disease or uveitis.

Primary outcomes:
measure: Long-term outcomes after treatment
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Wenzhou
country: China
facility: Xiaobing Wang
state: Zhejiang
Study officials:
References: