Clinical trial NCT00412984: Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation
Official title: A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects With Nonvalvular Atrial Fibrillation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Atrial Fibrillation
Atrial Flutter
Lead sponsor: Bristol-Myers Squibb
Sponsor class: INDUSTRY
First posted: 2006-12-19
Enrollment: 20976
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.


Eligibility criteria: Inclusion Criteria:

* Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:
* Age ≥ 75, previous stroke
* transient ischemic attack (TIA) or Systemic Embolism (SE)
* Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%
* Diabetes mellitus or hypertension requiring pharmacological treatment

Primary outcomes:
measure: Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period
timeFrame: Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).
measure: Rate of Adjudicated Stroke or Systemic Embolism (SE) During the Intended Treatment Period
timeFrame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
Secondary outcomes:
measure: Number of Participants With Event of Major (International Society on Thrombosis and Hemostasis [ISTH]) Bleeding During Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
measure: Rate of Adjudicated Major (ISTH) Bleed Events During Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
measure: Number of Participants With Events of All-Cause Death During the Intended Treatment Period
timeFrame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
measure: Rate of Adjudicated All-Cause Death During the Intended Treatment Period
timeFrame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
measure: Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), and Myocardial Infarction (MI) (as Individual Endpoints) During the Intended Treatment Period
timeFrame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
measure: Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), Myocardial Infarction (MI) and All-Cause Death (ACD) (as Composite Endpoints) During the Intended Treatment Period
timeFrame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
measure: Number of Warfarin/Vitamin K Antagonist (VKA) Naive Participants With Composite Stroke / Systemic Embolism (SE) / Major Bleeding During the Intended Treatment Period
timeFrame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
measure: Rate of Composite Stroke / Systemic Embolism / Major Bleeding in Warfarin/Vitamin K Antagonist (VKA) Naive Participants During the Intended Treatment Period
timeFrame: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).
measure: Number of Participants With Events of Major or Clinically Relevant Nonmajor (CRNM) Bleed During Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
measure: Rate of Events of Major or Clinically Relevant Non-Major (CRNM) Bleed During Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
measure: Number of Participants With All Bleeding Events During Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
measure: Rate of All Bleeding Events During Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Other outcomes:
measure: Number of Participants With Adverse Events (AEs), Bleeding AEs, Serious Adverse Events (SAEs), Discontinuations Due to AEs, or Deaths During the Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
measure: Rate of Adjudicated Bleeding Endpoints Per Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) During the Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
measure: Rate of Adjudicated Bleeding Endpoints Per Thrombolysis in Myocardial Infarction (TIMI) During the Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
measure: Number of Participants With Net-Clinical Benefit During Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
measure: Rate of Net-Clinical Benefit During Treatment Period
timeFrame: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.
Locations:
city: Birmingham
country: United States
facility: Cardiovascular Associates, Pc
state: Alabama
city: Birmingham
country: United States
facility: Alabama Internal Medicine Pc
state: Alabama
city: Birmingham
country: United States
facility: Birmingham Heart Clinic P.C.
state: Alabama
city: Huntsville
country: United States
facility: Heart Center, Inc.
state: Alabama
city: Mobile
country: United States
facility: Mobile Heart Specialists, Pc
state: Alabama
city: Mobile
country: United States
facility: Clara V. Massey, Md
state: Alabama
city: Anchorage
country: United States
facility: Alaska Heart Institute
state: Alaska
city: Phoenix
country: United States
facility: Internal Medicine Physicians Associates, P.C.
state: Arizona
city: Tucson
country: United States
facility: Southwest Heart
state: Arizona
city: Tucson
country: United States
facility: Southern Arizona Va Health Care System
state: Arizona
city: Tucson
country: United States
facility: Pima Research Foundation
state: Arizona
city: Hot Springs
country: United States
facility: Dr. Rajesh Shroff
state: Arkansas
city: Little Rock
country: United States
facility: Mary K. Richards, Md Pa
state: Arkansas
city: Anaheim
country: United States
facility: Advanced Clinical Reserach Institute
state: California
city: Beverly Hills
country: United States
facility: Act/Cardiovascular Research Institute
state: California
city: Carmichael
country: United States
facility: Capitol Interventional Cardiology
state: California
city: Escondido
country: United States
facility: Escondido Cardiology Associates, Inc.
state: California
city: Healdsburg
country: United States
facility: William D. Bowden, D.O.
state: California
city: La Mesa
country: United States
facility: La Mesa Cardiac Center, A Medical Group
state: California
city: Los Angeles
country: United States
facility: Va Greater Los Angeles Healthcare System
state: California
city: Mission Viejo
country: United States
facility: Coastal Cardiology
state: California
city: Oceanside
country: United States
facility: Kenneth W. Carr Md
state: California
city: Palm Springs
country: United States
facility: Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group
state: California
city: Rancho Mirage
country: United States
facility: Desert Cardiology Consultants Medical Group, Inc
state: California
city: Sacramento
country: United States
facility: Regional Cardiolody Associates
state: California
city: Sacramento
country: United States
facility: Northern California Research
state: California
city: Sacramento
country: United States
facility: Sacramento Heart And Vascular Medical Associates
state: California
city: Santa Barbara
country: United States
facility: Arrhythmia Consultants Of The Central Coast Medical Group
state: California
city: Santa Rosa
country: United States
facility: Northern California Medical Associates
state: California
city: Vista
country: United States
facility: Progressive Clinical Research
state: California
city: Walnut Creek
country: United States
facility: Cardivasclular Consultants Medical Group
state: California
city: Wildomar
country: United States
facility: Shiva Heart Center Medical Group
state: California
city: Colorado Springs
country: United States
facility: Electrophysiology Associates, Pc
state: Colorado
city: Denver
country: United States
facility: Aurora Denver Cardiology Associates, P.C.
state: Colorado
city: Denver
country: United States
facility: Denver Va Medical Center
state: Colorado
city: Golden
country: United States
facility: New West Physicians Clinical Research
state: Colorado
city: Littleton
country: United States
facility: South Denver Cardiology Associates Pc
state: Colorado
city: Bridgeport
country: United States
facility: Connecticut Clinical Research, Llc
state: Connecticut
city: Bridgeport
country: United States
facility: Bridgeport Hospital
state: Connecticut
city: Guilford
country: United States
facility: Cardiology Associates Of New Haven,Pc
state: Connecticut
city: Norwich
country: United States
facility: The William W. Backus Hospital
state: Connecticut
city: Norwich
country: United States
facility: William W Backus Hospital
state: Connecticut
city: Stamford
country: United States
facility: Stamford Therapeutics Consortium
state: Connecticut
city: Waterbury
country: United States
facility: Chase Medical Research, Llc
state: Connecticut
city: Newark
country: United States
facility: Alfieri Cardiology
state: Delaware
city: Washington
country: United States
facility: George Washington University Medical Faculty Associates
state: District of Columbia
city: Washington
country: United States
facility: Washington Va Medical Center
state: District of Columbia
city: Atlantis
country: United States
facility: Medical Specialist Of The Palm Beach
state: Florida
city: Aventura
country: United States
facility: Miami International Cardiology Consultants
state: Florida
city: Boca Raton
country: United States
facility: David Charles Mishkel, Md, Pa
state: Florida
city: Clearwater
country: United States
facility: The Heart & Vascular Institute Of Florida
state: Florida
city: Clearwater
country: United States
facility: The Heart And Vascular Institute Of Florida
state: Florida
city: Davie
country: United States
facility: Cardiovascular Specialist Of South Florida
state: Florida
city: Daytona Beach
country: United States
facility: Daytona Heart Group
state: Florida
city: Fort Lauderdale
country: United States
facility: Cardiology Associates Of Fort Lauderdale, P.A.
state: Florida
city: Fort Lauderdale
country: United States
facility: Broward General Medical Center
state: Florida
city: Fort Myers
country: United States
facility: Florida Heart Associates
state: Florida
city: Gainesville
country: United States
facility: Florida Research Network, Llc
state: Florida
city: Hollywood
country: United States
facility: Healthworx
state: Florida
city: Hollywood
country: United States
facility: Luis Tami, Md
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research
state: Florida
city: Jacksonville Beach
country: United States
facility: Jacksonville Heart Center, P.A.
state: Florida
city: Jacksonville
country: United States
facility: St. Vincent'S Ambulatory Care, Inc
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Heart Center, Pa
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Cardiovascular Center
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Center For Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: St. Luke'S Cardiology
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Heart Center, Pa
state: Florida
city: Jupiter
country: United States
facility: Cvms Research Institute, Llc
state: Florida
city: Jupiter
country: United States
facility: Ricardo Bedoya, M.D.
state: Florida
city: Melbourne
country: United States
facility: Melbourne Internal Medicine Associates
state: Florida
city: Miami
country: United States
facility: Miami International Cardiology Consultants
state: Florida
city: Miami
country: United States
facility: Miami International Cardiology Consultants
state: Florida
city: Naples
country: United States
facility: Physicians Regional Medical Group
state: Florida
city: Orlando
country: United States
facility: Florida Heart Group
state: Florida
city: Oviedo
country: United States
facility: Alpha Medical Research
state: Florida
city: Pensacola
country: United States
facility: Cardiology Consultants
state: Florida
city: Saint Petersburg
country: United States
facility: The Heart And Vascular Institute Of Florida
state: Florida
city: Sarasota
country: United States
facility: Niranjan Seshadri, Md
state: Florida
city: Sarasota
country: United States
facility: Heart & Vascular Center Research, Inc.
state: Florida
city: Vero Beach
country: United States
facility: Research, Inc.
state: Florida
city: Atlanta
country: United States
facility: Cardiovascular Specialits, Pc
state: Georgia
city: Augusta
country: United States
facility: Augusta Cardiology Clinic, P.C.
state: Georgia
city: Columbus
country: United States
facility: Columbus Cardiology Associates Pc
state: Georgia
city: Columbus
country: United States
facility: Columbus Cardiology Associates,Pc
state: Georgia
city: Covington
country: United States
facility: Georgia Heart Specialists, L.L.C.
state: Georgia
city: Decatur
country: United States
facility: Atlanta Institute For Medical Research, Inc
state: Georgia
city: Gainesville
country: United States
facility: Northeast Georgia Heart Center, Pc
state: Georgia
city: Marietta
country: United States
facility: Wellstar Cardiovascular Medicine, Pc
state: Georgia
city: Aurora
country: United States
facility: Fox Valley Clinical Research Center, Llc
state: Illinois
city: Chicago
country: United States
facility: Nmff
state: Illinois
city: Gurnee
country: United States
facility: Clinical Investigation Specialists, Inc
state: Illinois
city: Maywood
country: United States
facility: Loyola University Medical Center
state: Illinois
city: Normal
country: United States
facility: Illinois Heart & Lung Research Center, Sc
state: Illinois
city: North Chicago
country: United States
facility: Cpt. James A Lovell Federal Health Care Center
state: Illinois
city: Anderson
country: United States
facility: Community Clinical Research Center
state: Indiana
city: Bloomington
country: United States
facility: Premier Healthcare, Llc
state: Indiana
city: Elkhart
country: United States
facility: Elkhart Clinic, Llc
state: Indiana
city: Fort Wayne
country: United States
facility: Lutheran Medical Group, Llc
state: Indiana
city: Fort Wayne
country: United States
facility: Fort Wayne Cardiology
state: Indiana
city: Indianapolis
country: United States
facility: St Francis Medical Group - Indiana Heart Physicians
state: Indiana
city: Indianapolis
country: United States
facility: The Care Group, Llc.
state: Indiana
city: Indianapolis
country: United States
facility: The Care Group, Llc
state: Indiana
city: Michigan City
country: United States
facility: Dali, Sammi
state: Indiana
city: South Bend
country: United States
facility: Cardiology Associates, Inc.
state: Indiana
city: Ames
country: United States
facility: Mcfarland Clinic Pc
state: Iowa
city: Overland Park
country: United States
facility: Midwest Cardiology Associates , P.C.
state: Kansas
city: Elizabethtown
country: United States
facility: Central Cardiology Assoc.
state: Kentucky
city: Lexington
country: United States
facility: New Lexington Clinic, P.S.C.
state: Kentucky
city: Louisville
country: United States
facility: Va Medical Center
state: Kentucky
city: Louisville
country: United States
facility: Norton Cardiovascular Associates
state: Kentucky
city: Owensboro
country: United States
facility: Owensboro Heart & Vascular
state: Kentucky
city: Alexandria
country: United States
facility: Alexandria Cardiology Clinic
state: Louisiana
city: Houma
country: United States
facility: Cardiovascular Institute Of The South
state: Louisiana
city: Lacombe
country: United States
facility: Smith, Patel & Amkieh, Llc
state: Louisiana
city: Lake Charles
country: United States
facility: Imperial Calcasieu Medical Group, Llp
state: Louisiana
city: Marrero
country: United States
facility: Cardiology Center, Llc
state: Louisiana
city: Shreveport
country: United States
facility: Cardiology Associates
state: Louisiana
city: Slidell
country: United States
facility: Louisiana Heart Center
state: Louisiana
city: Slidell
country: United States
facility: Medical Research Inst, Inc
state: Louisiana
city: Slidell
country: United States
facility: Medical Research Institute, Inc
state: Louisiana
city: Ventura
country: United States
facility: Ventura Cardio. Cond. Med. Group, Inc.
state: Louisiana
city: Lewiston
country: United States
facility: Central Maine Heart & Vascular Institute
state: Maine
city: Baltimore
country: United States
facility: Midatlantic Cardiovascular Associates, P.A.
state: Maryland
city: Baltimore
country: United States
facility: Midatlantic Cardiovascular Associates, Pa
state: Maryland
city: Baltimore
country: United States
facility: Midatlantic Cardiovascular Associates, P.A.
state: Maryland
city: Baltimore
country: United States
facility: Johns Hopkins Bayview Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Johns Hopkins Bayview Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Franklin Square Hospital
state: Maryland
city: Baltimore
country: United States
facility: Midatlantic Cardiovascular Associates, P.A.
state: Maryland
city: Baltimore
country: United States
facility: Midatlantic Cardiovascular Associates, Pa
state: Maryland
city: Bel Air
country: United States
facility: Midatlantic Cardiovascular Associates, Pa
state: Maryland
city: Columbia
country: United States
facility: Cardiovascular Specialists Of Central Maryland, P.A.
state: Maryland
city: Reisterstown
country: United States
facility: Clinical Associates Research
state: Maryland
city: Westminster
country: United States
facility: Midatlantic Cardiovascular Associates, Pa
state: Maryland
city: Billerica
country: United States
facility: Burlington Medical Associates
state: Massachusetts
city: Boston
country: United States
facility: Caritas St. Elizabeth'S Medical Center
state: Massachusetts
city: Burlington
country: United States
facility: Lahey Clinic Medical Center
state: Massachusetts
city: Fall River
country: United States
facility: Neccr Internal Medicine & Cardiology Associates,Llc
state: Massachusetts
city: Haverhill
country: United States
facility: Pentucket Medical Associates
state: Massachusetts
city: Haverhill
country: United States
facility: Pentucket Medical Associates
state: Massachusetts
city: Natick
country: United States
facility: Charles River Medical Associates
state: Massachusetts
city: Alpena
country: United States
facility: Great Lakes Heart Center Of Alpena
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Lansing
country: United States
facility: Thoracic And Cardiovascular Healthcare Foundation
state: Michigan
city: Livonia
country: United States
facility: Advanced Cardiovascular Health Specialists, Pc
state: Michigan
city: Petoskey
country: United States
facility: Michigan Heart And Vascular Specialists
state: Michigan
city: Royal Oak
country: United States
facility: William Beaumont Hospital
state: Michigan
city: Ypsilanti
country: United States
facility: Michigan Heart, P.C.
state: Michigan
city: Minneapolis
country: United States
facility: Minneapolis Va Medical Center
state: Minnesota
city: Minneapolis
country: United States
facility: University Of Minnesota
state: Minnesota
city: Robbinsdale
country: United States
facility: North Memorial Health Care
state: Minnesota
city: Olive Branch
country: United States
facility: Olive Branch Family Medical Center
state: Mississippi
city: Tupelo
country: United States
facility: Tupelo Neurology Clinic, Pa
state: Mississippi
city: Columbia
country: United States
facility: University Of Missouri
state: Missouri
city: Kansas City
country: United States
facility: Truman Medical Center
state: Missouri
city: Kansas City
country: United States
facility: Saint Luke'S Lipid And Diabetes Research Center
state: Missouri
city: Grand Island
country: United States
facility: Internal Medical Associates of Grand Island, P.C
state: Nebraska
city: Grand Island
country: United States
facility: Internal Medical Associates Of Grand Island, P.C
state: Nebraska
city: Hastings
country: United States
facility: Nebraska Heart Institute
state: Nebraska
city: Las Vegas
country: United States
facility: Va Southern Nevada Healthcare System
state: Nevada
city: Berlin
country: United States
facility: Comprehensive Clinical Research
state: New Jersey
city: Elmer
country: United States
facility: Cardiovascular Associates Of The Delware Valley, P.A.
state: New Jersey
city: Haddon Heights
country: United States
facility: Cardiovascular Associates Of The Delaware Valley, P.A.
state: New Jersey
city: Princeton
country: United States
facility: Princeton Medical Institute
state: New Jersey
city: Sewell
country: United States
facility: Cardio Assoc Of Del Val, P.A.
state: New Jersey
city: South Plainfield
country: United States
facility: Central New Jersey Cardiology
state: New Jersey
city: Albuquerque
country: United States
facility: Abq Health Partners, Llc
state: New Mexico
city: Albuquerque
country: United States
facility: University Of New Mexico/University Hospital
state: New Mexico
city: Albuquerque
country: United States
facility: University Of New Mexico/University Hospital
state: New Mexico
city: Albany
country: United States
facility: Albany Assoc. In Cardiology
state: New York
city: Albany
country: United States
facility: Albany Associates In Cardiology
state: New York
city: Binghamton
country: United States
facility: Cardiology Associates, Pc
state: New York
city: Buffalo
country: United States
facility: Buffalo Heart Group, Llp
state: New York
city: Buffalo
country: United States
facility: Bruce L. Platt Md, Pc
state: New York
city: Buffalo
country: United States
facility: Bruce L. Platt, Md
state: New York
city: Buffalo
country: United States
facility: Buffalo Heart Group, Llp
state: New York
city: East Syracuse
country: United States
facility: Heart Care Center, P.C.
state: New York
city: Huntington
country: United States
facility: Huntington Hospital
state: New York
city: Liverpool
country: United States
facility: Sjh Cardiology Associates
state: New York
city: Mineola
country: United States
facility: Long Island Heart Associates
state: New York
city: Saratoga Springs
country: United States
facility: Saratoga Cardiology Associates, Pc
state: New York
city: Williamsville
country: United States
facility: Office Of Dr. Kozinn
state: New York
city: Williamsville
country: United States
facility: Suburban Cardiology
state: New York
city: Asheville
country: United States
facility: Asheville Cardiology Associates
state: North Carolina
city: Burlington
country: United States
facility: Kernodle Clinic, Inc.
state: North Carolina
city: High Point
country: United States
facility: Carolina Cardiology Associates, Pa
state: North Carolina
city: Pinehurst
country: United States
facility: Pinehurst Medical Center, Inc
state: North Carolina
city: Fargo
country: United States
facility: Lillestol Research Llc
state: North Dakota
city: Akron
country: United States
facility: Akron Cardiology Consultants
state: Ohio
city: Bucyrus
country: United States
facility: Christopher M. Johnson, D.O.
state: Ohio
city: Bucyrus
country: United States
facility: Christopher M. Johnson, D.O.
state: Ohio
city: Canal Fulton
country: United States
facility: Community Health Care, Inc.
state: Ohio
city: Canton
country: United States
facility: Cardiology Associates
state: Ohio
city: Cincinnati
country: United States
facility: The Carl & Edyth Lindner Center For R&E At The Christ Hosp
state: Ohio
city: Toledo
country: United States
facility: Toledo Cardiology Consultants
state: Ohio
city: Wadsworth
country: United States
facility: Family Practice Center Of Wadsworth, Inc.
state: Ohio
city: Muskogee
country: United States
facility: Jack C. Va Medical Center
state: Oklahoma
city: Oklahoma City
country: United States
facility: Cor Clinical Research, Llc
state: Oklahoma
city: Oklahoma City
country: United States
facility: University Of Oklahoma Health Sciences Center
state: Oklahoma
city: Oklahoma City
country: United States
facility: Plaza Medical Group, Pc
state: Oklahoma
city: Oklahoma City
country: United States
facility: Oklahoma Heart Hospital Physicians
state: Oklahoma
city: Oklahoma City
country: United States
facility: South Oklahoma Heart Research
state: Oklahoma
city: Oklahoma City
country: United States
facility: Eminence Research, Llc
state: Oklahoma
city: Tulsa
country: United States
facility: Castlerock Clinical Research Consultants, Llc
state: Oklahoma
city: Bend
country: United States
facility: St. Charles Health System, Inc.
state: Oregon
city: Bend
country: United States
facility: St. Charles Health System, Inc
state: Oregon
city: Eugene
country: United States
facility: Oregon Medical Group - Clinical Research
state: Oregon
city: Hillsboro
country: United States
facility: Hillsboro Cardiology Pc
state: Oregon
city: Medford
country: United States
facility: Rogue Valley Physicians - Clinical Research Group
state: Oregon
city: Abington
country: United States
facility: Abington Medical Specialists
state: Pennsylvania
city: Altoona
country: United States
facility: Blair Medical Associates, Inc.
state: Pennsylvania
city: Camp Hill
country: United States
facility: Heritage Cardiology Assoc.
state: Pennsylvania
city: Doylestown
country: United States
facility: Central Bucks Cardiology
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city: Erie
country: United States
facility: Internal Medicine And Lipid Mgmt.
state: Pennsylvania
city: Harrisburg
country: United States
facility: Kandra, Fierer, Kuskin Associates
state: Pennsylvania
city: Hatfield
country: United States
facility: Pivotal Clinical Research, Llc
state: Pennsylvania
city: Jersey Shore
country: United States
facility: Lycoming Internal Medicine Inc.
state: Pennsylvania
city: Sayre
country: United States
facility: Guthrie Clinic Ltd.
state: Pennsylvania
city: Sayre
country: United States
facility: Guthrie Medical Group, P.C.
state: Pennsylvania
city: Uniontown
country: United States
facility: Preferred Primary Care Physicians
state: Pennsylvania
city: West Chester
country: United States
facility: West Chester Cardiology, Pc
state: Pennsylvania
city: Yardley
country: United States
facility: Cardiology Consultants Of Philadelphia
state: Pennsylvania
city: Providence
country: United States
facility: Rhode Island Hospital
state: Rhode Island
city: Anderson
country: United States
facility: Southeastern Research Associates, Inc
state: South Carolina
city: Beaufort
country: United States
facility: Lowcountry Medical Group, Llc
state: South Carolina
city: Beaufort
country: United States
facility: Lowcountry Medical Group
state: South Carolina
city: Charleston
country: United States
facility: Medical University Of South Carolina
state: South Carolina
city: Columbia
country: United States
facility: Columbia Heart Clinic
state: South Carolina
city: Greenville
country: United States
facility: Upstate Cardiology
state: South Carolina
city: Greer
country: United States
facility: Internal Medicine Of Greer
state: South Carolina
city: Orangeburg
country: United States
facility: Palmetto Nephrology Pa
state: South Carolina
city: Spartanburg
country: United States
facility: S. Carolina Pharmaceutical Research
state: South Carolina
city: Pierre
country: United States
facility: Avera Medical Associates Clinic
state: South Dakota
city: Bristol
country: United States
facility: Holston Medical Group
state: Tennessee
city: Kingsport
country: United States
facility: Holston Medical Group
state: Tennessee
city: Knoxville
country: United States
facility: Knoxville Heart Group
state: Tennessee
city: Knoxville
country: United States
facility: Volunteer Research Group
state: Tennessee
city: Knoxville
country: United States
facility: Volunteer Research Group
state: Tennessee
city: Tullahoma
country: United States
facility: Tennessee Center For Clinical Trials
state: Tennessee
city: Amarillo
country: United States
facility: Amarillo Heart Clinical Research Institute Inc.
state: Texas
city: Corsicana
country: United States
facility: Corsicana Medical Research, Pllc
state: Texas
city: Dallas
country: United States
facility: Soltero Cardiovascular Research Center
state: Texas
city: Dallas
country: United States
facility: Heartplace
state: Texas
city: Fort Worth
country: United States
facility: Heart Center Of North Texas
state: Texas
city: Houston
country: United States
facility: Center For Atrial Fibrillation
state: Texas
city: Houston
country: United States
facility: The Methodist Hospital Neurology Institute
state: Texas
city: Houston
country: United States
facility: The Methodist Hospital
state: Texas
city: Houston
country: United States
facility: The University Of Texas Md Anderson Cancer Center
state: Texas
city: Houston
country: United States
facility: Northwest Houston Cardiology, Pa
state: Texas
city: Houston
country: United States
facility: Northwest Houston Cardiology, Pa
state: Texas
city: Houston
country: United States
facility: Francisco R. Maislos
state: Texas
city: Houston
country: United States
facility: Woodlands North Houston Heart Center
state: Texas
city: Humble
country: United States
facility: Regional Medical Center And Diagnostic Clinics
state: Texas
city: Lackland Air Force Base
country: United States
facility: Wilford Hall Medical Center
state: Texas
city: Lackland Air Force Base
country: United States
facility: Wilford Hall Medical Center
state: Texas
city: Longview
country: United States
facility: Dcol Center For Clinical Research
state: Texas
city: McKinney
country: United States
facility: North Dallas Research Associates
state: Texas
city: Plano
country: United States
facility: Legacy Heart Center
state: Texas
city: Plano
country: United States
facility: North Texas Medical Research
state: Texas
city: San Antonio
country: United States
facility: Bhs Specialty Network, Inc
state: Texas
city: San Antonio
country: United States
facility: Covenant Clinical Research, Pa
state: Texas
city: San Antonio
country: United States
facility: Star Clinical Trails
state: Texas
city: Seguin
country: United States
facility: Edward Balli, Md, Pa
state: Texas
city: Tomball
country: United States
facility: Northwest Heart Center
state: Texas
city: Tyler
country: United States
facility: Tyler Cardiovascular Consultants
state: Texas
city: Tyler
country: United States
facility: The Univ. Of Texas Health Science Ctr. At Tyler
state: Texas
city: Tyler
country: United States
facility: University Of Texas Health Science Center At Tyler
state: Texas
city: Layton
country: United States
facility: Utah Cardiology P.C
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city: Norfolk
country: United States
facility: Sentara York Clinical Research
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city: Richmond
country: United States
facility: Medical Research Initiatives
state: Virginia
city: Roanoke
country: United States
facility: Roanoke Heart Institute, Plc
state: Virginia
city: Virginia Beach
country: United States
facility: Cardiovascular Associates
state: Virginia
city: Burien
country: United States
facility: Daniel W. Gottlieb, Md, Ps
state: Washington
city: Burien
country: United States
facility: Daniel William Gottlieb, Md
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city: Spokane
country: United States
facility: Rockwood Clinic Research Cent.
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city: Walla Walla
country: United States
facility: Walla Walla Clinic
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city: Lewisburg
country: United States
facility: Lynn N. Smith, Md
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city: Green Bay
country: United States
facility: Cardiology Associates Of Green Bay Ltd-Bellin Hospital
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city: Madison
country: United States
facility: St. Mary'S Hospital
state: Wisconsin
city: Madison
country: United States
facility: St.Mary'S Hospital
state: Wisconsin
city: Milwaukee
country: United States
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state: Wisconsin
city: Milwaukee
country: United States
facility: Medical College Of Wisconsin
state: Wisconsin
city: Waukesha
country: United States
facility: Cardiology Assc. Of Waukesha
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city: Adrogue
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state: Buenos Aires
city: Bahia Blanca
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country: Australia
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country: Australia
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country: Brazil
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country: Brazil
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country: Brazil
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country: Brazil
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country: Brazil
facility: Local Institution
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country: Brazil
facility: Local Institution
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country: Brazil
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country: Brazil
facility: Local Institution
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country: Brazil
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country: Brazil
facility: Local Institution
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country: Brazil
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country: Brazil
facility: Local Institution
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country: Canada
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country: Canada
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country: China
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country: China
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
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facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Nizhni Novgorod
country: Russian Federation
facility: Local Institution
city: Nizhni Novgorod
country: Russian Federation
facility: Local Institution
city: Novosibirsk
country: Russian Federation
facility: Local Institution
city: Novosibirsk
country: Russian Federation
facility: Local Institution
city: Odintsovo
country: Russian Federation
facility: Local Institution
city: Penza
country: Russian Federation
facility: Local Institution
city: Perm
country: Russian Federation
facility: Local Institution
city: Rostov-On-Don
country: Russian Federation
facility: Local Institution
city: Ryazan
country: Russian Federation
facility: Local Institution
city: Saint Petersburg
country: Russian Federation
facility: Local Institution
city: Saint Petersburg
country: Russian Federation
facility: Local Institution
city: Saint-Petersburg
country: Russian Federation
facility: Local Institution
city: Saint-Petersburg
country: Russian Federation
facility: Local Institution
city: Saint-Petersburg
country: Russian Federation
facility: Local Institution
city: Saint-Petersburg
country: Russian Federation
facility: Local Institution
city: Saint-Petersburg
country: Russian Federation
facility: Local Institution
city: Samara
country: Russian Federation
facility: Local Institution
city: Saratov
country: Russian Federation
facility: Local Institution
city: St Petersburg
country: Russian Federation
facility: Local Institution
city: St Petersburg
country: Russian Federation
facility: Local Institution
city: St-Petersburg
country: Russian Federation
facility: Local Institution
city: St-Petersburg
country: Russian Federation
facility: Local Institution
city: St. Petersburg
country: Russian Federation
facility: Local Institution
city: St. Petersburg
country: Russian Federation
facility: Local Institution
city: St.-Petersburg
country: Russian Federation
facility: Local Institution
city: St.Petersburg
country: Russian Federation
facility: Local Institution
city: Tomsk
country: Russian Federation
facility: Local Institution
city: Tumen
country: Russian Federation
facility: Local Institution
city: Tver
country: Russian Federation
facility: Local Institution
city: Voronezh
country: Russian Federation
facility: Local Institution
city: Voronezh
country: Russian Federation
facility: Local Institution
city: Yaroslavl
country: Russian Federation
facility: Local Institution
city: Yaroslavl
country: Russian Federation
facility: Local Institution
city: Yaroslavl
country: Russian Federation
facility: Local Institution
city: Zheleznodorozhniy
country: Russian Federation
facility: Local Institution
city: Zhukovsky
country: Russian Federation
facility: Local Institution
city: Zhukovsky
country: Russian Federation
facility: Local Institution
city: Singapore
country: Singapore
facility: Local Institution
city: Westdene
country: South Africa
facility: Local Institution
state: Bloemfontein
city: Observatory
country: South Africa
facility: Local Institution
state: Cape Town
city: Pretoria
country: South Africa
facility: Local Institution
state: Gauteng
city: Pretoria
country: South Africa
facility: Local Institution
state: Gauteng
city: Richards Bay
country: South Africa
facility: Local Institution
state: KWA ZULU Natal
city: Bellville Cape Town
country: South Africa
facility: Local Institution
state: Western CAPE
city: George
country: South Africa
facility: Local Institution
state: Western CAPE
city: Parow
country: South Africa
facility: Local Institution
state: Western CAPE
city: Somerset West
country: South Africa
facility: Local Institution
state: Western CAPE
city: Worcester
country: South Africa
facility: Local Institution
state: Western CAPE
city: San Juan
country: Spain
facility: Local Institution
state: Alicante
city: Torrevieja
country: Spain
facility: Local Institution
state: Alicante
city: La Canada
country: Spain
facility: Local Institution
state: Almeria
city: Lugo
country: Spain
facility: Local Institution
state: Galicia
city: Albacete
country: Spain
facility: Local Institution
city: Barcelona
country: Spain
facility: Local Institution
city: Barcelona
country: Spain
facility: Local Institution
city: Elda
country: Spain
facility: Local Institution
city: Figueres
country: Spain
facility: Local Institution
city: Gerona
country: Spain
facility: Local Institution
city: Las Palmas
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Palma De Mallorca
country: Spain
facility: Local Institution
city: San Sebastian De Los Reyes
country: Spain
facility: Local Institution
city: Tarragona
country: Spain
facility: Local Institution
city: Viladecans
country: Spain
facility: Local Institution
city: Goteberg
country: Sweden
facility: Local Institution
city: Helsingborg
country: Sweden
facility: Local Institution
city: Linkoping
country: Sweden
facility: Local Institution
city: Lund
country: Sweden
facility: Local Institution
city: Orebro
country: Sweden
facility: Local Institution
city: Orebro
country: Sweden
facility: Local Institution
city: Skelleftea
country: Sweden
facility: Local Institution
city: Stockholm
country: Sweden
facility: Local Institution
city: Stockholm
country: Sweden
facility: Local Institution
city: Stockholm
country: Sweden
facility: Local Institution
city: Stockholm
country: Sweden
facility: Local Institution
city: Stockholm
country: Sweden
facility: Local Institution
city: Uppsala
country: Sweden
facility: Local Institution
city: Vaxjo
country: Sweden
facility: Local Institution
city: Baden
country: Switzerland
facility: Local Institution
city: Bern
country: Switzerland
facility: Local Institution
city: Taipei
country: Taiwan
facility: Local Institution
city: Taipei
country: Taiwan
facility: Local Institution
city: Taipei
country: Taiwan
facility: Local Institution
city: Taipei
country: Taiwan
facility: Local Institution
city: Taipei
country: Taiwan
facility: Local Institution
city: Taipei
country: Taiwan
facility: Local Institution
city: Ankara
country: Turkey
facility: Local Institution
city: Eskisehir
country: Turkey
facility: Local Institution
city: Izmir
country: Turkey
facility: Local Institution
city: Chernivtsy
country: Ukraine
facility: Local Institution
city: Dnipropetrovsk
country: Ukraine
facility: Local Institution
city: Dnipropetrovsk
country: Ukraine
facility: Local Institution
city: Donetsk
country: Ukraine
facility: Local Institution
city: Donetsk
country: Ukraine
facility: Local Institution
city: Donetsk
country: Ukraine
facility: Local Institution
city: Ivano-Frankivsk
country: Ukraine
facility: Local Institution
city: Kharkiv
country: Ukraine
facility: Local Institution
city: Kharkiv
country: Ukraine
facility: Local Institution
city: Kharkov
country: Ukraine
facility: Local Institution
city: Kharkov
country: Ukraine
facility: Local Institution
city: Kharkov
country: Ukraine
facility: Local Institution
city: Kiev
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Lugansk
country: Ukraine
facility: Local Institution
city: Lugansk
country: Ukraine
facility: Local Institution
city: Lutsk
country: Ukraine
facility: Local Institution
city: Lviv
country: Ukraine
facility: Local Institution
city: Lviv
country: Ukraine
facility: Local Institution
city: Mykolayiv
country: Ukraine
facility: Local Institution
city: Odessa
country: Ukraine
facility: Local Institution
city: Odessa
country: Ukraine
facility: Local Institution
city: Odessa
country: Ukraine
facility: Local Institution
city: Odessa
country: Ukraine
facility: Local Institution
city: Uzhgorod
country: Ukraine
facility: Local Institution
city: Vinnitsa
country: Ukraine
facility: Local Institution
city: Zaporozhye
country: Ukraine
facility: Local Institution
city: Zhytomyr
country: Ukraine
facility: Local Institution
city: Aberdeen
country: United Kingdom
facility: Local Institution
state: Aberdeenshire
city: Glasgow
country: United Kingdom
facility: Local Institution
state: Aberdeenshire
city: Belfast
country: United Kingdom
facility: Local Institution
state: Antrim
city: Craigavon
country: United Kingdom
facility: Local Institution
state: Armagh
city: Cambridge
country: United Kingdom
facility: Local Institution
state: Cambridgeshire
city: Peterborough
country: United Kingdom
facility: Local Institution
state: Cambridgeshire
city: Chesterfield
country: United Kingdom
facility: Local Institution
state: Derbyshire
city: Chesterfield
country: United Kingdom
facility: Local Institution
state: Derbyshire
city: Bournemouth
country: United Kingdom
facility: Local Institution
state: Dorset
city: Glasgow
country: United Kingdom
facility: Local Institution
state: Dumbartonshire
city: Chichester
country: United Kingdom
facility: Local Institution
state: EAST Sussex
city: Colchester
country: United Kingdom
facility: Local Institution
state: Essex
city: Romford
country: United Kingdom
facility: Local Institution
state: Essex
city: Denmark Hill
country: United Kingdom
facility: Local Institution
state: Greater London
city: London
country: United Kingdom
facility: Local Institution
state: Greater London
city: Newport
country: United Kingdom
facility: Local Institution
state: Gwent
city: Barnet
country: United Kingdom
facility: Local Institution
state: Hertfordshire
city: Cardiff
country: United Kingdom
facility: Local Institution
state: MID Glamorgan
city: Llandough
country: United Kingdom
facility: Local Institution
state: MID Glamorgan
city: Harrow
country: United Kingdom
facility: Local Institution
state: Middlesex
city: Nottingham
country: United Kingdom
facility: Local Institution
state: Nottinghamshire
city: Worksop
country: United Kingdom
facility: Local Institution
state: Nottinghamshire
city: Paisley
country: United Kingdom
facility: Local Institution
state: Renfrewshire
city: Barnsley
country: United Kingdom
facility: Local Institution
state: South Yorkshire
city: Doncaster
country: United Kingdom
facility: Local Institution
state: South Yorkshire
city: Stirling
country: United Kingdom
facility: Local Institution
state: Stirlingshire
city: Glasgow
country: United Kingdom
facility: Local Institution
state: Strathclyde
city: Bury St Edmunds
country: United Kingdom
facility: Local Institution
state: Suffolk
city: Bury St Edmunds
country: United Kingdom
facility: Local Institution
state: Suffolk
city: Bury St. Edmunds
country: United Kingdom
facility: Local Institution
state: Suffolk
city: Ipswich
country: United Kingdom
facility: Local Institution
state: Suffolk
city: Ipswich
country: United Kingdom
facility: Local Institution
state: Suffolk
city: Newcastle Upon Tyne
country: United Kingdom
facility: Local Institution
state: Tyne and Wear
city: Swansea
country: United Kingdom
facility: Local Institution
state: WEST Glamorgan
city: Livingston
country: United Kingdom
facility: Local Institution
state: WEST Lothian
city: Birmingham
country: United Kingdom
facility: Local Institution
state: WEST Midlands
city: Westbury
country: United Kingdom
facility: Local Institution
state: Wiltshire
city: Westbury
country: United Kingdom
facility: Local Institution
state: Wiltshire
city: York
country: United Kingdom
facility: Local Institution
state: Yorkshire
city: York
country: United Kingdom
facility: Local Institution
state: Yorkshire
city: Antrim
country: United Kingdom
facility: Local Institution
city: Blackpool
country: United Kingdom
facility: Local Institution
city: Glasgow
country: United Kingdom
facility: Local Institution
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References:
citation: Jamieson MJ, Byon W, Dettloff RW, Crawford M, Gargalovic PS, Merali SJ, Onorato J, Quintero AJ, Russ C. Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data. Am J Cardiovasc Drugs. 2022 Nov;22(6):615-631. doi: 10.1007/s40256-022-00524-x. Epub 2022 May 16.
citation: Pol T, Hijazi Z, Lindback J, Oldgren J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Yusuf S, Siegbahn A, Wallentin L. Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation. Cardiovasc Res. 2022 Jul 20;118(9):2112-2123. doi: 10.1093/cvr/cvab262.
citation: Pol T, Hijazi Z, Lindback J, Alexander JH, Bahit MC, De Caterina R, Eikelboom JW, Ezekowitz MD, Gersh BJ, Granger CB, Hylek EM, Lopes R, Siegbahn A, Wallentin L. Evaluation of the prognostic value of GDF-15, ABC-AF-bleeding score and ABC-AF-death score in patients with atrial fibrillation across different geographical areas. Open Heart. 2021 Mar;8(1):e001471. doi: 10.1136/openhrt-2020-001471.
citation: Hijazi Z, Wallentin L, Lindback J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Pol T, Yusuf S, Oldgren J, Siegbahn A. Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation. J Am Heart Assoc. 2020 Dec 15;9(24):e018984. doi: 10.1161/JAHA.120.018984. Epub 2020 Dec 9.
citation: Wallentin L, Lindback J, Eriksson N, Hijazi Z, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Yusuf S, Oldgren J, Siegbahn A. Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. Eur Heart J. 2020 Nov 1;41(41):4037-4046. doi: 10.1093/eurheartj/ehaa697.
citation: Hijazi Z, Granger CB, Hohnloser SH, Westerbergh J, Lindback J, Alexander JH, Keltai M, Parkhomenko A, Lopez-Sendon JL, Lopes RD, Siegbahn A, Wallentin L. Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation. J Am Heart Assoc. 2020 Sep 15;9(18):e017155. doi: 10.1161/JAHA.120.017155. Epub 2020 Aug 31.
citation: Zeitouni M, Giczewska A, Alexander JH. Reply: Specifics of Dose Modification in ARISTOTLE. J Am Coll Cardiol. 2020 Jul 7;76(1):128-129. doi: 10.1016/j.jacc.2020.05.013. No abstract available.
citation: Rosjo H, Hijazi Z, Omland T, Westerbergh J, Lyngbakken MN, Alexander JH, Gersh BJ, Granger CB, Hylek EM, Lopes RD, Siegbahn A, Wallentin L. Cardiac troponin is associated with cardiac outcomes in men and women with atrial fibrillation, insights from the ARISTOTLE trial. J Intern Med. 2020 Aug;288(2):248-259. doi: 10.1111/joim.13072. Epub 2020 May 18.
citation: Zeitouni M, Giczewska A, Lopes RD, Wojdyla DM, Christersson C, Siegbahn A, De Caterina R, Steg PG, Granger CB, Wallentin L, Alexander JH; ARISTOTLE Investigators. Clinical and Pharmacological Effects of Apixaban Dose Adjustment in the ARISTOTLE Trial. J Am Coll Cardiol. 2020 Mar 17;75(10):1145-1155. doi: 10.1016/j.jacc.2019.12.060.
citation: Stanifer JW, Pokorney SD, Chertow GM, Hohnloser SH, Wojdyla DM, Garonzik S, Byon W, Hijazi Z, Lopes RD, Alexander JH, Wallentin L, Granger CB. Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease. Circulation. 2020 Apr 28;141(17):1384-1392. doi: 10.1161/CIRCULATIONAHA.119.044059. Epub 2020 Mar 12.
citation: Garcia DA, Fisher DA, Mulder H, Wruck L, De Caterina R, Halvorsen S, Granger CB, Held C, Wallentin L, Alexander JH, Lopes RD. Gastrointestinal bleeding in patients with atrial fibrillation treated with Apixaban or warfarin: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial. Am Heart J. 2020 Mar;221:1-8. doi: 10.1016/j.ahj.2019.10.013. Epub 2019 Oct 31.
citation: Dalgaard F, Mulder H, Wojdyla DM, Lopes RD, Held C, Alexander JH, De Caterina R, Washam JB, Hylek EM, Garcia DA, Gersh BJ, Wallentin L, Granger CB, Al-Khatib SM. Patients With Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial. Circulation. 2020 Jan 7;141(1):10-20. doi: 10.1161/CIRCULATIONAHA.119.041296. Epub 2019 Nov 21.
citation: Goldstein SA, Green J, Huber K, Wojdyla DM, Lopes RD, Alexander JH, Vinereanu D, Wallentin L, Granger CB, Al-Khatib SM. Characteristics and Outcomes of Atrial Fibrillation in Patients With Thyroid Disease (from the ARISTOTLE Trial). Am J Cardiol. 2019 Nov 1;124(9):1406-1412. doi: 10.1016/j.amjcard.2019.07.046. Epub 2019 Aug 7.
citation: Guimaraes PO, Pokorney SD, Lopes RD, Wojdyla DM, Gersh BJ, Giczewska A, Carnicelli A, Lewis BS, Hanna M, Wallentin L, Vinereanu D, Alexander JH, Granger CB. Efficacy and safety of apixaban vs warfarin in patients with atrial fibrillation and prior bioprosthetic valve replacement or valve repair: Insights from the ARISTOTLE trial. Clin Cardiol. 2019 May;42(5):568-571. doi: 10.1002/clc.23178. Epub 2019 Apr 9.
citation: Washam JB, Hohnloser SH, Lopes RD, Wojdyla DM, Vinereanu D, Alexander JH, Gersh BJ, Hanna M, Horowitz J, Hylek EM, Xavier D, Verheugt FWA, Wallentin L, Granger CB; ARISTOTLE Committees and Investigators. Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial. J Thromb Thrombolysis. 2019 Apr;47(3):345-352. doi: 10.1007/s11239-019-01823-y.
citation: Hohnloser SH, Fudim M, Alexander JH, Wojdyla DM, Ezekowitz JA, Hanna M, Atar D, Hijazi Z, Bahit MC, Al-Khatib SM, Lopez-Sendon JL, Wallentin L, Granger CB, Lopes RD. Efficacy and Safety of Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Extremes in Body Weight. Circulation. 2019 May 14;139(20):2292-2300. doi: 10.1161/CIRCULATIONAHA.118.037955.
citation: Alexander KP, Brouwer MA, Mulder H, Vinereanu D, Lopes RD, Proietti M, Al-Khatib SM, Hijazi Z, Halvorsen S, Hylek EM, Verheugt FWA, Alexander JH, Wallentin L, Granger CB; ARISTOTLE Investigators. Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial. Am Heart J. 2019 Feb;208:123-131. doi: 10.1016/j.ahj.2018.09.017. Epub 2018 Nov 22.
citation: Sandhu RK, Ezekowitz JA, Hijazi Z, Westerbergh J, Aulin J, Alexander JH, Granger CB, Halvorsen S, Hanna MS, Lopes RD, Siegbahn A, Wallentin L. Obesity paradox on outcome in atrial fibrillation maintained even considering the prognostic influence of biomarkers: insights from the ARISTOTLE trial. Open Heart. 2018 Nov 1;5(2):e000908. doi: 10.1136/openhrt-2018-000908. eCollection 2018.
citation: Christersson C, Wallentin L, Andersson U, Alexander JH, Alings M, De Caterina R, Gersh BJ, Granger CB, Halvorsen S, Hanna M, Huber K, Hylek EM, Lopes RD, Oh BH, Siegbahn A. Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation. Heart. 2019 Feb;105(3):235-242. doi: 10.1136/heartjnl-2018-313351. Epub 2018 Sep 12.
citation: Horowitz JD, De Caterina R, Heresztyn T, Alexander JH, Andersson U, Lopes RD, Steg PG, Hylek EM, Mohan P, Hanna M, Jansky P, Granger CB, Wallentin L; ARISTOTLE Investigators. Asymmetric and Symmetric Dimethylarginine Predict Outcomes in Patients With Atrial Fibrillation: An ARISTOTLE Substudy. J Am Coll Cardiol. 2018 Aug 14;72(7):721-733. doi: 10.1016/j.jacc.2018.05.058.
citation: Sharma A, Hijazi Z, Andersson U, Al-Khatib SM, Lopes RD, Alexander JH, Held C, Hylek EM, Leonardi S, Hanna M, Ezekowitz JA, Siegbahn A, Granger CB, Wallentin L. Use of Biomarkers to Predict Specific Causes of Death in Patients With Atrial Fibrillation. Circulation. 2018 Oct 16;138(16):1666-1676. doi: 10.1161/CIRCULATIONAHA.118.034125.
citation: Kopin D, Jones WS, Sherwood MW, Wojdyla DM, Wallentin L, Lewis BS, Verheugt FWA, Vinereanu D, Bahit MC, Halvorsen S, Huber K, Parkhomenko A, Granger CB, Lopes RD, Alexander JH. Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin: Insights from the ARISTOTLE trial. Am Heart J. 2018 Mar;197:133-141. doi: 10.1016/j.ahj.2017.11.005. Epub 2017 Nov 10.
citation: Pol T, Held C, Westerbergh J, Lindback J, Alexander JH, Alings M, Erol C, Goto S, Halvorsen S, Huber K, Hanna M, Lopes RD, Ruzyllo W, Granger CB, Hijazi Z. Dyslipidemia and Risk of Cardiovascular Events in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Therapy: Insights From the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) Trial. J Am Heart Assoc. 2018 Feb 1;7(3):e007444. doi: 10.1161/JAHA.117.007444.
citation: Goto S, Merrill P, Wallentin L, Wojdyla DM, Hanna M, Avezum A, Easton JD, Harjola VP, Huber K, Lewis BS, Parkhomenko A, Zhu J, Granger CB, Lopes RD, Alexander JH. Antithrombotic therapy use and clinical outcomes following thrombo-embolic events in patients with atrial fibrillation: insights from ARISTOTLE. Eur Heart J Cardiovasc Pharmacother. 2018 Apr 1;4(2):75-81. doi: 10.1093/ehjcvp/pvy002.
citation: Vinereanu D, Wang A, Mulder H, Lopes RD, Jansky P, Lewis BS, Gersh BJ, Avezum A, Hanna M, Held C, Wallentin L, Granger CB, Alexander JH. Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease. Heart. 2018 Aug;104(15):1292-1299. doi: 10.1136/heartjnl-2017-312272. Epub 2018 Jan 19.
citation: Rao MP, Vinereanu D, Wojdyla DM, Alexander JH, Atar D, Hylek EM, Hanna M, Wallentin L, Lopes RD, Gersh BJ, Granger CB; Apixaban for Reduction in Stroke Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators. Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial. Am J Med. 2018 Mar;131(3):269-275.e2. doi: 10.1016/j.amjmed.2017.10.036. Epub 2017 Nov 6.
citation: Vinereanu D, Lopes RD, Mulder H, Gersh BJ, Hanna M, de Barros E Silva PGM, Atar D, Wallentin L, Granger CB, Alexander JH; ARISTOTLE Investigators. Echocardiographic Risk Factors for Stroke and Outcomes in Patients With Atrial Fibrillation Anticoagulated With Apixaban or Warfarin. Stroke. 2017 Dec;48(12):3266-3273. doi: 10.1161/STROKEAHA.117.017574. Epub 2017 Oct 31.
citation: Hijazi Z, Oldgren J, Lindback J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Held C, Hylek EM, Lopes RD, Yusuf S, Granger CB, Siegbahn A, Wallentin L; ARISTOTLE and RE-LY Investigators. A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score. Eur Heart J. 2018 Feb 7;39(6):477-485. doi: 10.1093/eurheartj/ehx584.
citation: Hijazi Z, Lindahl B, Oldgren J, Andersson U, Lindback J, Granger CB, Alexander JH, Gersh BJ, Hanna M, Harjola VP, Hylek EM, Lopes RD, Siegbahn A, Wallentin L. Repeated Measurements of Cardiac Biomarkers in Atrial Fibrillation and Validation of the ABC Stroke Score Over Time. J Am Heart Assoc. 2017 Jun 23;6(6):e004851. doi: 10.1161/JAHA.116.004851.
citation: Lopes RD, Guimaraes PO, Kolls BJ, Wojdyla DM, Bushnell CD, Hanna M, Easton JD, Thomas L, Wallentin L, Al-Khatib SM, Held C, Gabriel Melo de Barros E Silva P, Alexander JH, Granger CB, Diener HC. Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation therapy. Blood. 2017 Jun 1;129(22):2980-2987. doi: 10.1182/blood-2016-08-731638. Epub 2017 Mar 29.
citation: Cowper PA, Sheng S, Lopes RD, Anstrom KJ, Stafford JA, Davidson-Ray L, Al-Khatib SM, Ansell J, Dorian P, Husted S, McMurray JJV, Steg PG, Alexander JH, Wallentin L, Granger CB, Mark DB. Economic Analysis of Apixaban Therapy for Patients With Atrial Fibrillation From a US Perspective: Results From the ARISTOTLE Randomized Clinical Trial. JAMA Cardiol. 2017 May 1;2(5):525-534. doi: 10.1001/jamacardio.2017.0065.
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