Clinical trial NCT05693350: Etiology Of Recurrent Varicose Veins After Stripping Or Ablation Of Superficial Venous System
Official title: Etiology Of Recurrent Varicose Veins After Stripping Or Ablation Of Superficial
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Recurrent Varicose Vein of Lower Limb (Disorder)
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-01-23
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with previous history of intervention for varicose veins

Brief summary: Number of patients and causes and patterns of recurrent varicose veins in the lower limbs in patients with history of varicose veins stripping or ablation of the superficial venous system.

Detailed description: Recurrence of varicose veins following surgery is a common, complex and costly problem in vascular surgery. Despite improvements in preoperative evaluation and methods of treatment, recurrence following varicose vein surgery is reported to occur in between 20 and 80% of cases. Many theories have been put forward concerning the underlying mechanisms and causes. These include poor understanding of the venous anatomy and haemodynamics, inadequate preoperative assessment, inappropriate or incomplete surgery and development of new sites of venous reflux as a consequence of disease progression or neovascularisation. However, it is difficult to evaluate these suggestions since the studies from which they arise vary greatly in their definitions of recurrence, preoperative assessment, initial treatment, classification and method and duration of follow-up.

Eligibility criteria: Inclusion Criteria:

* 1) Ages eligible for the study: 18-60. 2) Sexes eligible for the study: All. 3) Patients with previous intervention for varicose veins. 4) Patients with primary or secondary varicosities. 5) Patient's compliance to follow-up.

Exclusion Criteria:

1) Patients with no history of interventions for varicose veins. 2) Patients treated with injection sclerotherapy alone. 3) Pregnant women. 4) Patients with arterial disease in the same limb (ABI \<0.8). 5) Patients with post-thrombotic syndrome

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Primary outcomes:
measure: Etiology of recurrence of varicose veins in patients previously treated by stripping and ligation or endovenous ablation.
timeFrame: Five years
Secondary outcomes:
measure: Quality of life was assessed by the Aberdeen Varicose Vein Questionnaire (AVVQ)
timeFrame: Five years
Other outcomes:
Locations:
Study officials:
References:
citation: Kostas T, Ioannou CV, Touloupakis E, Daskalaki E, Giannoukas AD, Tsetis D, Katsamouris AN. Recurrent varicose veins after surgery: a new appraisal of a common and complex problem in vascular surgery. Eur J Vasc Endovasc Surg. 2004 Mar;27(3):275-82. doi: 10.1016/j.ejvs.2003.12.006.
citation: Blomgren L, Johansson G, Dahlberg-AKerman A, Noren A, Brundin C, Nordstrom E, Bergqvist D. Recurrent varicose veins: incidence, risk factors and groin anatomy. Eur J Vasc Endovasc Surg. 2004 Mar;27(3):269-74. doi: 10.1016/j.ejvs.2003.12.022.
citation: Hamdan A. Management of varicose veins and venous insufficiency. JAMA. 2012 Dec 26;308(24):2612-21. doi: 10.1001/jama.2012.111352.