Clinical trial NCT02163668: Effects of Yoga on Bone Metabolism in Premenopausal Women
Official title: Effects of an 8-month Yoga Intervention on Bone Metabolism in Healthy Middle-aged Premenopausal Women: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bone Health
Osteoporosis
Keywords: Yoga
Bone turnover markers
Bone strength
Bone mineral density
Lead sponsor: University of Oklahoma
Sponsor class: OTHER
First posted: 2014-06-16
Enrollment: 47
Sex: FEMALE
Minimum age (years): 35
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study examined the effects of 8 months of Yoga training on bone density and bone turnover markers in premenopausal women, ages 35-50 years. The style of Yoga used was power Yoga that involved postures with a jumping component. The investigators hypothesized that the Yoga intervention would result in beneficial improvements in bone turnover markers, by increasing the bone formation marker and decreasing the bone resorption marker.


Eligibility criteria: Inclusion Criteria:

* participants had not been engaged in resistance training or in Yoga exercise for at least 12 months prior to the study
* did not have chronic back or joint problems or cardiovascular disease
* not taking antihypertensive drugs or any medication that affects bone density
* not taking hormonal contraception
* they self-reported having regular menstrual cycles.

Exclusion Criteria:

* body weight more than 300 pounds

Primary outcomes:
measure: Change in bone mineral density from baseline to 8 months
timeFrame: pre and post 8 months training
measure: change in bone turnover markers
timeFrame: pre and post 8 month intervention
measure: change in tibia bone characteristics
timeFrame: pre and post 8 month intervention
measure: Changes in muscular strength
timeFrame: pre and post 9 month intervention
measure: Change in arterial compliance
timeFrame: pre and post 8 month interventon
measure: Change in Insulin-like Growth Factor-1 (IGF-I) and Insulin-like Growth Factor BP3 (IGFBP3)
timeFrame: pre and post 8 month intervention
Secondary outcomes:
measure: Daily Calcium intake
timeFrame: pre and post 8 month intervention
measure: Menstrual History
timeFrame: pre and post 8 month intervention
measure: Dietary intake
timeFrame: At baseline at the same time as other outcomes, about 2 weeks before the beginning of the yoga training
measure: Change in physical activity levels
timeFrame: pre and post 8 month intervention
measure: Change in body composition
timeFrame: pre and post 8 month intervention
Other outcomes:
Locations:
city: Norman
country: United States
facility: Department of Health and Exercise Science, University of Oklahoma
state: Oklahoma
Study officials:
affiliation: Department of Health and Exercise Science, University of Oklahoma
name: Debra A Bemben, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Phoosuwan M, Kritpet T, Yuktanandana P. The effects of weight bearing yoga training on the bone resorption markers of the postmenopausal women. J Med Assoc Thai. 2009 Sep;92 Suppl5:S102-8.
citation: Chan K, Qin L, Lau M, Woo J, Au S, Choy W, Lee K, Lee S. A randomized, prospective study of the effects of Tai Chi Chun exercise on bone mineral density in postmenopausal women. Arch Phys Med Rehabil. 2004 May;85(5):717-22. doi: 10.1016/j.apmr.2003.08.091.