Clinical trial NCT03831464: Metformin as RenoProtector of Progressive Kidney Disease
Official title: Metformin as RenoProtector in Non-Diabetic Patients With Progressive Chronic Kidney Disease (CKD Stages 2, 3A and 3B): a Multi-centre, Practice-oriented, Repurposing, Double-blind, Placebo-controlled, Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Chronic Kidney Diseases
Keywords: CKD
Metformin
Renoprotector
Lead sponsor: Universiteit Antwerpen
Sponsor class: OTHER
Collaborators: name: University Hospital, Antwerp
First posted: 2019-02-05
Enrollment: 290
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A multi-center, practice-oriented, repurposing, double-blinded, placebo-controlled, randomized clinical trial. The RenoMet trial is repurposing an already approved agent (Metformin , Glucophage SR) in a new indication (renoprotection) in a new class of patients (chronic kidney disease patients CKD 2, 3A, 3B and including patients with renal transplant for more than 3 years),
Primary purpose: TREATMENT

Brief summary: A multi-center, practice-oriented, repurposing, double-blinded, placebo-controlled, randomized clinical trial. The RenoMet trial is repurposing an already approved agent (Metformin , Glucophage SR ) in a new indication (renoprotection ) in a new class of patients (chronic kidney disease patients CKD 2, 3A, 3B and including patients with renal transplant for more than 3 years).

Detailed description: The intervention consists in the treatment of patients with progressive kidney disease and blindly randomized to the treatment group with metformin as medication, added to their usual treatment. Metformin is a well-known and cheap medication used for many years and still used as main treatment of type 2 diabetes. In our study, this 'old' product will be used for a 'new' indication, slowing down the progression of CKD. After randomization in the participating renal care clinic, patients in the intervention group will be treated with metformin at a dose of 1000 mg/day (2x500mg) in the evening during 30 months (Metformin - Glucophage SR (Merck KGaA)). During the first month of the trial a dose of 1x500mg will be used in order to avoid as much as possible some well-known mainly gastrointestinal side effects of metformin treatment At each visit during the study period, the metformin medication will be hand over to the patient in a HDPE bottle, closed with a MEMS cap (Medication Event Monitoring System). The MEMS a cap that registers the time and date of each opening (presumed intake of the medication in the bottle).

Patients blindly randomized to the control group will receive placebo treatment (2 tablets per day) also in a MEMS device and will continue to receive usual care. Control patients will have the same data collection.

Follow-up of patients during the entire study period will be the responsibility of the treating nephrologist in the renal care clinic. All patients will have a baseline data collection at study entry (demographics, comorbidities, concomitant medication, clinical parameters, lab results). During the study period of 30 months patients will have follow-up visits at their renal care clinic every four months with collection of follow-up data (concomitant medication, clinical parameters, routine lab results and drug related problems). Extra blood and urine samples will be collected for a centralized second determination of serum creatinine and proteinuria.

Eligibility criteria: Inclusion Criteria:

* Adult patients (≥18 years) of both gender
* Seen on a regular base in one of the participating outpatient clinics of renal care with a previous consultation within the last year
* Having a chronic kidney disease (including having a transplant kidney for more than 3 years) with:

  * a CKD stage 2, 3A or 3B (i.e. with estimated glomerular filtration rate (eGFR) between 30 and 70 ml/min/1.73m2) at the time of the baseline visit
  * showing a decline of eGFR between 3.0 and 20.0 ml/min/year determined using at least three determinations of eGFR (CKD-Epi formula) whereby the oldest one should be from more than 1 year ago and the most recent will be the one of the baseline visit. For transplant patients the decline will be based on serum creatinine values determined during the preceding 24 months. For all other patients, the decline will be based on values determined within the last five years

Exclusion Criteria:

1. Illiteracy: patients not knowing how to read or write
2. Patients not able to communicate in Dutch or French
3. Patients with mental deterioration, incapable to give informed consent and to understand the safety instructions of the study (at the discretion of the treating nephrologist)
4. Patients with one of the following clinical problems:

   * Patients with nephrotic syndrome
   * Patients showing a fast decline of renal function (more than 20 ml/min/year) during the preceding five years
   * Diabetes mellitus (any type: 1, 2, Maturity Onset Diabetes of the Young (MODY), New Onset Diabetes After Transplantation (NODAT)) confirmed by a glycemia level \>125 mg/dl (7.0 mmol/L) after a fasting time of 8 hours
   * Patients with a renal transplantation for less than 3 years
   * Patients with multi-organ transplantation
   * History of other solid organ transplantations
   * Chronic obstructive pulmonary disease (COPD) stage Gold IV (Oxygene-dependency)
   * Congestive heart failure (NYHA stage IV)
   * Inflammatory bowel disease (IBD)
   * Stoma
   * Hepatic insufficiency or cirrhosis, acute alcohol intoxication or alcoholism (\> 20 glasses of alcoholic beverages per week)
   * History of metabolic diseases (e.g. mitochondrial encephalomyopathy (MELAS), lactic acidosis, stroke-like episodes, etc...)
   * Pregnancy and/or lactating women at the time of recruitment and during the study period
   * Patient with prior use of metformin within the past 12 months (e.g. glucose intolerance, polycystic ovary syndrome, etc...) or with other study medication taken within the framework of another clinical trial
5. Patients showing elevated blood lactate level(s) at the time of recruitment (i.e. a confirmed lactate level ≥ 2.5 mmol/L at baseline and a confirmed lactate level ≥ 2.5 mmol/L after 4 weeks (±1 week)).
6. Patients showing a confirmed (after 3 months) serum bicarbonate level \< 22 mmol/L (or \< 20 mmol/L if delay of more than 1 hour between sampling and determination)
7. Hypersensitivity to metformin or to any of the excipients listed in section 6.1 of the Glucophage SR SmPC (see Attachment A5 Glucophage SR SmPC)
8. One of the following diseases during the previous 6 months: myocardial infarction, shock, acute problems of decompensated heart failure or respiratory failure.

Primary outcomes:
measure: Reaching a 30% decline of eGFR
timeFrame: Period of 30 months
Secondary outcomes:
measure: Mortality rate during the investigation period
timeFrame: Period of 30 months
measure: Evolution of the renal function
timeFrame: Period of 30 months
measure: Percentage of patients developing end-stage renal disease
timeFrame: Period of 30 months
measure: Percentage of transplant patients with graft loss
timeFrame: Period of 30 months
measure: Evolution of proteinuria
timeFrame: Difference between baseline and study end
measure: Evolution of hypertension
timeFrame: Difference between baseline and study end
measure: Frequency of Major Adverse Cardiovascular Events
timeFrame: Period of 30 months
measure: Hospitalization during the investigation period
timeFrame: Period of 30 months
measure: Hospitalization during the investigation period
timeFrame: Period of 30 months
measure: (Serious) Adverse drug events
timeFrame: Period of 30 months
measure: Evolution of Quality of life
timeFrame: Period of 30 months
Other outcomes:
Locations:
city: Roeselare
country: Belgium
facility: AZ Delta
state: West-Vlaanderen
city: Aalst
country: Belgium
facility: OLVZ Aalst
city: Ath
country: Belgium
facility: Epicura Ath
city: Baudour
country: Belgium
facility: Epicura Baudour
city: Bonheiden
country: Belgium
facility: Imelda Ziekenhuis Bonheiden
city: Brussels
country: Belgium
facility: Hôpital Erasme
city: Brussel
country: Belgium
facility: CHU Brugmann
city: Brussel
country: Belgium
facility: UZ Brussel
city: Charleroi
country: Belgium
facility: Grand Hôpital de Charleroi
city: Edegem
country: Belgium
facility: Antwerp University Hospital
city: Ghent
country: Belgium
facility: Ghent University Hospital
city: Hasselt
country: Belgium
facility: Jessa Ziekenhuis
city: Liège
country: Belgium
facility: Centre Hospitalier Régional de la Citadelle
city: Liège
country: Belgium
facility: Centre Hospitalier Universitaire Liège (CHU Liège)
city: Namur
country: Belgium
facility: Centre Hospitalier Régional de Namur
city: Sint-Niklaas
country: Belgium
facility: AZ Nikolaas
city: Tournai
country: Belgium
facility: Centre Hospitalier de Wallonie Picarde
city: Turnhout
country: Belgium
facility: AZ Turnhout
city: Verviers
country: Belgium
facility: CHR Verviers
Study officials:
References: