Clinical trial NCT04995250: Effects of Corrective Exercise Training for Improving Neuropathic Pain and Function in Knee Osteoarthritis
Official title: Effects of Corrective Exercise Training for Improving Neuropathic Pain and Function in Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteoarthritis, Knee
Keywords: Knee osteoarthritis
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2021-08-06
Enrollment: 16
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Patients with neuropathic pain had longer duration of symptoms increased severity of pain, functional limitation and disability as compare to the patient with general knee osteoarthritis.

Objective: To find out the effects of corrective exercise training for improving neuropathic pain and function in knee OA patients.

Detailed description: This study was a Quasi experimental study. It was conducted at Horizon Hospital Johar Town Lahore. The study was completed in Six months. Consecutive sampling technique was used to collect the data. The sample size of 16 patients was taken in this study to find out the effects of corrective exercises training for improving neuropathic pain and function in patients with knee osteoarthritis. For descriptive analysis we used frequency, percentages and charts. For quantitative measure. Repeated Measured ANOVA was used.

Eligibility criteria: Inclusion Criteria:

* ACR Criteria for osteoarthritis
* Neuropathic pain
* Age over 65
* DN4 cut off value is 4/10
* Less than 30 minutes of morning stiffness
* Grade I and II
* Crepitus on active motion
* Bony tenderness
* Bony enlargement
* No palpable warmth of synovium

Exclusion Criteria:

* Knee complain that require urgent medical attention (fracture and infection)
* Diabetes mellitus
* Patients with malignancies
* Neurological disorders
* Systematic musculoskeletal diseases (Parkinson's, rheumatoid arthritis etc)
* Incapability of understanding implication of participants

Primary outcomes:
measure: Western Ontario and McMaster Osteoarthritis Index
timeFrame: 6 months
measure: Numeric pain rating scale
timeFrame: 6 months
measure: Douleur Neuropathique 4 Questionnaire
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Riphah Rehabilitation Center
state: Punjab
Study officials:
affiliation: Riphah International University
name: Maryam Shabbir, MS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Polat CS, Dogan A, Sezgin Ozcan D, Koseoglu BF, Kocer Akselim S. Is There a Possible Neuropathic Pain Component in Knee Osteoarthritis? Arch Rheumatol. 2017 Apr 24;32(4):333-338. doi: 10.5606/ArchRheumatol.2017.6006. eCollection 2017 Dec.
citation: Nelson AE, Allen KD, Golightly YM, Goode AP, Jordan JM. A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative. Semin Arthritis Rheum. 2014 Jun;43(6):701-12. doi: 10.1016/j.semarthrit.2013.11.012. Epub 2013 Dec 4.
citation: Knoop J, Steultjens MP, van der Leeden M, van der Esch M, Thorstensson CA, Roorda LD, Lems WF, Dekker J. Proprioception in knee osteoarthritis: a narrative review. Osteoarthritis Cartilage. 2011 Apr;19(4):381-8. doi: 10.1016/j.joca.2011.01.003. Epub 2011 Jan 18.
citation: Takacs J, Carpenter MG, Garland SJ, Hunt MA. The role of neuromuscular changes in aging and knee osteoarthritis on dynamic postural control. Aging Dis. 2013 Jan 15;4(2):84-99. Print 2013 Apr.
citation: Beckwee D, Vaes P, Cnudde M, Swinnen E, Bautmans I. Osteoarthritis of the knee: why does exercise work? A qualitative study of the literature. Ageing Res Rev. 2013 Jan;12(1):226-36. doi: 10.1016/j.arr.2012.09.005. Epub 2012 Sep 28.
citation: Sazo-Rodriguez S, Mendez-Rebolledo G, Guzman-Munoz E, Rubio-Palma P. The effects of progressive neuromuscular training on postural balance and functionality in elderly patients with knee osteoarthritis: a pilot study. J Phys Ther Sci. 2017 Jul;29(7):1229-1235. doi: 10.1589/jpts.29.1229. Epub 2017 Jul 15.