Clinical trial NCT05612802: A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)
Official title: A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acute Kidney Injury (Nontraumatic)
Pneumoperitoneum
Lead sponsor: Baskent University
Sponsor class: OTHER
First posted: 2022-11-10
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared. In our study, we aimed to investigate the effect of pneumoperitoneum applied on acute kidney injury in patients who underwent laparoscopic surgery. Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. Our study investigates whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.


Eligibility criteria: Inclusion Criteria:

* Patients aged 18-70 years of both sexes
* ASA I-III Patients

Exclusion Criteria:

* Obesity,
* Chronic Kidney Disease,
* Chronic Renal Failure,
* Acute Renal Failure,
* Peripheral and ischemic vascular disease,
* Chronic Heart Failure,
* History of anaphylaxis,
* A-V block,
* Creatinine level \>1.4,
* Neuromuscular disease,
* Malignant hypertension,
* Pyelonephritis,
* Urinary tract infectio,
* Severe inflammation/possible sepsis,
* Active malignancy,
* Patients with surgery reversion to laparotomy,
* Hemodynamic instability, need for vasopressors,
* Severe bleeding requiring blood transfusion,

Primary outcomes:
measure: Diagnosis of acute kidney injury in the early postoperative period with IGF-1 (insulin like growth factor-1)
timeFrame: before pneumoperitoneum, after pneumoperitoneum, and at the postoperative 24th hour.
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Çağla Yazar, MD
Study officials:
affiliation: Baskent University
name: NEDİM ÇEKMEN, PHD
role: STUDY_DIRECTOR
References:
citation: Gumbert SD, Kork F, Jackson ML, Vanga N, Ghebremichael SJ, Wang CY, Eltzschig HK. Perioperative Acute Kidney Injury. Anesthesiology. 2020 Jan;132(1):180-204. doi: 10.1097/ALN.0000000000002968.
citation: Marton Filho MA, Alves RL, Nascimento PD Junior, Tarquinio GDS, Mega PF, Pinheiro Modolo NS. Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial. PLoS One. 2021 Feb 19;16(2):e0247088. doi: 10.1371/journal.pone.0247088. eCollection 2021.
citation: Sun B, Fu A, Wang R, Zhang Y. Influence of carbon dioxide pneumoperitoneum on the growth hormone-insulin-like growth factor I axis in mid- and late-pregnancy rats. J Obstet Gynaecol Res. 2015 Sep;41(9):1394-8. doi: 10.1111/jog.12734. Epub 2015 Jun 22.
citation: Srisawat N, Kongwibulwut M, Laoveeravat P, Lumplertgul N, Chatkaew P, Saeyub P, Latthaprecha K, Peerapornratana S, Tiranathanagul K, Eiam-Ong S, Tungsanga K. The role of intraoperative parameters on predicting laparoscopic abdominal surgery associated acute kidney injury. BMC Nephrol. 2018 Oct 22;19(1):289. doi: 10.1186/s12882-018-1081-4.