louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02146638: Post Operative Pain Control: Morphine vs Fentanyl
Official title: Post Operative Pain Control: Continuous Infusion of Morphine vs Fentanyl. Clinical Outcomes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post Operative Analgesia
Keywords: post operative analgesia, morphine, fentanyl
Lead sponsor: Catholic University of the Sacred Heart
Sponsor class: OTHER
First posted: 2014-05-26
Enrollment: 60
Sex: FEMALE
Minimum age (years): 35
Maximum age (years): 59
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aim of this study is to compare benefits and disadvantages in using continuous infusion of morphine or fentanyl for post operative analgesia.


Eligibility criteria: Inclusion Criteria:

* ASA 1 or 2 patients
* undergoing major gynaecological surgery

Exclusion Criteria:

* age \> 60 years
* obesity (BMI\>30 Kg/m2)
* cardiac and respiratory diseases
* renal impairment
* liver disorders
* allergies to any drug used in the study

Primary outcomes:
measure: pain scores
timeFrame: data were recorded during the 24 post operative hours
Secondary outcomes:
measure: analgesic requirements
timeFrame: during the 24 hours after surgery
Other outcomes:
Locations:
city: Rome
country: Italy
facility: catholic University of the sacred Heart
Study officials:
References:
Clinical trial NCT03922243: An Analysis of Dental Treatments Rendered by Undergraduates at Ajman University to Patients From Fujairah, Uae
Official title: Dental Treatments Analysis Rendered by Undergraduates at Ajman University, Fujairah, Uae
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Treatment
Keywords: students
dental treatment
gender
age
Lead sponsor: Ajman University
Sponsor class: OTHER
First posted: 2019-04-19
Enrollment: 650
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients registered at Ajman University,Dental clinic,Fujairah

Brief summary: A total of 650 dental records were selected from 6000 dental records of patients who had received dental treatment in the Dental Clinic, College of Dentistry, Ajman University(AU)-Fujairah Campus, between academic year,2015/2016 and 2016/2017

Detailed description: A total of 650 dental records was randomly selected from 6000 dental records of patients who had received dental treatment in the Dental Clinic, College of Dentistry, Ajman Universi-ty(AU),Fujairah Campus, between the academic years 2015/2016 and 2016/2017. The size of study sample was determined using, Cochran' formula at 95% confidence. Using the random table generated by Microsoft Excel, the records for 650 patients were then randomly selected. After all the dental records to be included in this study were chosen and retrieved from the achieves. The following types of dental treatments: Composite restorations, amalgam restorations, glass ionomer restorations, fixed prosthetic treatments, removable prosthetic treatment, endodontic treatments, extractions treatments, fluoride treatments, fissure sealants treatment, pulp therapy treatments and stainless steel crowns treatments were extracted from the patient's dental records, coded and recorded in Microsoft excel sheet.

Eligibility criteria: Inclusion Criteria:

* Dental treatment performed in the time frame

Exclusion Criteria:

* Dental treatment not performed

Primary outcomes:
measure: Incidences of student performed dental treatment
timeFrame: From baseline to 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Fujairah
country: United Arab Emirates
facility: Ajman university
state: UAE
Study officials:
References:
Clinical trial NCT02909543: The Life Experience of Young Women (Age 18-38) Who Live With Congenital Heart Disease
Official title: The Life Experience of Young Women (Age 18-38) Who Live With Congenital Heart Disease
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Women With Congenital Heart Diseases
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2016-09-21
Enrollment: 15
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 38
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study aims to focus on women's stories about their life experiences and the influence of surgery(ies) on their daily life using an the qualitative phenomenological approach.

Brief summary: This research will focus on young women between the ages of 18-38 who underwent a heart operation and their life experiences. This research will focus on these life events and the paradigm of these women being raised as "heart sick," and consequently lacking self-esteem (Frigiola, Bull, \& Wray, 2014; Hickey et al., 2012). Most qualitative studies focusing on the quality of life compare men and women, completely ignoring women's body image and the experience of womanhood (Hickey et al., 2012; Hövels-Gürich et al., 2007; Sarikouch, et al., 2013). This study aims to focus on women's stories about their life experiences and the influence of surgery(ies) on their daily life using an the qualitative phenomenological approach.


Eligibility criteria: Inclusion Criteria:

* Atrial septal defect or ASD,
* Ventricle septal defect or VSD,
* Tetralogy of Fallot or TOF
* Translocation of great arteries or TGA
* underwent heart operation
* Hebrew speakers that are able to understand the meanings of the questions and tell their life stories.

Exclusion Criteria:

* Non Hebrew speakers
* Did not underwent heart surgery.

Primary outcomes:
measure: Interview about the life experience of young women (age 18-38) who live with congenital heart disease and overwent an open heart operation.
timeFrame: 1day, at the time of the interview
Secondary outcomes:
Other outcomes:
Locations:
city: Hadera
country: Israel
facility: Hillel Yaffe MC,
Study officials:
References:
Clinical trial NCT00053443: Handheld Computers to Improve Adherence to Anti-HIV Drug Regimens
Official title: Compliance Enhancement In HIV/AIDS Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: HIV Infections
Keywords: Adherence
Treatment Experienced
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Sponsor class: NIH
First posted: 2003-01-30
Enrollment: 156
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Primary purpose: TREATMENT

Brief summary: While anti-HIV drugs can significantly reduce viral loads, the medication regimens can be complex, and patients must take them correctly for the best effect. Nonadherent patients risk developing drug resistant HIV strains. The purpose of this study is to evaluate the effectiveness of a handheld computerized system designed to help patients take their drugs correctly.

Detailed description: As the use of protease inhibitors and other antiretroviral medications has increased, multiple drug resistant HIV strains have emerged, demonstrating the need for improved patient adherence to complex drug regimens. Individual computerized adherence systems have been proposed as a mechanism for improving patient adherence. This study will utilize advanced computer and communication technologies to produce a handheld (PDA) product for HIV/AIDS patients. The system serves as a patient reminder system, addresses problems of missed medications, and monitors severity of side effects. This study will evaluate the efficacy of the system as an adherence intervention.

Participants in the study will be randomized to either the intervention or a control group. Participants will use the PDA daily for medication reminders, alarms, adherence tracking, and as a source of information on HIV/AIDS. The study will last 15 weeks. Each participant will have 6 study interviews and 2 quality control interviews. Study interviews will include adherence questionnaires, blood tests for viral load and CD4 data, and quality of life assessments.

Eligibility criteria: Inclusion Criteria

* HIV positive
* Currently taking medications for HIV/AIDS.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Newton
country: United States
facility: Inflexxion
state: Massachusetts
Study officials:
References:
Clinical trial NCT02193243: Value of 6-minute Walk Test in Grown Ups With Congenital Heart Defects (GUCH)
Official title: The Diagnostic Value of Six-Minute Walk Test in Grown-Up Patients With Congenital Heart Disease (GUCH)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Congenital Heart Disease
Keywords: Congenital Heart Disease
Six Minute Walk Test
Exercise Testing
Peak oxygen uptake
Lead sponsor: Heinrich-Heine University, Duesseldorf
Sponsor class: OTHER
First posted: 2014-07-17
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patient with Congenital Heart Disease

Brief summary: The six-minute walk test is an established submaximal exercise test. Its role in examination of grown-up patients with congenital heart disease (GUCH) is not studied so far. Objective of this study was a comparison of the 6MWT with other established parameters of functional capacity, in grown-up patients with GUCH.


Eligibility criteria: Inclusion Criteria:

* congenital heart defect
* \> 18 years

Exclusion Criteria:

* mental or physical incapability of exercise testing
* non-cardiac limitations of physical capacity, as e.g. orthopedic diseases or febrile infections
* severe psychiatric diseases

Primary outcomes:
measure: Ranges of six-minute walk distance (6MWD)
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Duesseldorf
country: Germany
facility: Heinrich Heine University Div. of Cardiology, Pulmonary Disease and Vasculae Medicine
Study officials:
affiliation: Division of Cardiology, Pulmonary Disease and Vascular Medicine
name: Eva S Kehmeier, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Division of Cardiology, Pulmonary Disease and Vascular Medicine
name: Malte Kelm, MD
role: STUDY_CHAIR
References:
citation: Kehmeier ES, Sommer MH, Galonska A, Zeus T, Verde P, Kelm M. Diagnostic value of the six-minute walk test (6MWT) in grown-up congenital heart disease (GUCH): Comparison with clinical status and functional exercise capacity. Int J Cardiol. 2016 Jan 15;203:90-7. doi: 10.1016/j.ijcard.2015.10.074. Epub 2015 Oct 22.
Clinical trial NCT06640543: Effect of Kinesiotape Versus Myofascial Release on Postnatal Low Back Pain
Official title: Effect of Kinesiotape Versus Myofascial Release on Postnatal Low Back Pain: a Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Low Back Pain
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-10-15
Enrollment: 60
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to determine the difference between the effect of kinesiotape and myofascial release in the treatment of postnatal low back pain.

Detailed description: Postpartum back pain may occur in up to 44% of women after childbirth. People who have chronic back pain may have a limited range of motion and/or tenderness upon touch.

Therapeutic KT can benefit a wide variety of musculoskeletal and sports injuries, plus inflammatory conditions. According to the Kinesiotape Method Manual, this traction promotes an elevation of the epidermis and reduces pressure on the mechanoreceptors located below the dermis, thereby reducing nociceptive stimuli and low back pain.

Myofascial release (MFR) is a treatment that uses gentle pressure and stretching to facilitate the release of fascial restrictions caused by accidents, injury, stress, repetitive use, and traumatic or surgical scarring.

Myofascial release is a form of soft tissue therapy used to treat somatic dysfunction and accompanying pain and restriction of motion. This is accomplished by relaxing the contracted muscle, increasing circulation, increasing venous and lymphatic drainage, and stimulating the stretch reflex of muscles and overlying fascia so, reducing low back pain.

Eligibility criteria: Inclusion Criteria:

* Their ages will be ranged from 20 to 35 years old.
* Their body mass index (BMI) will not exceed 30 kg/m2.
* Women will be postnatal period by 6-8 weeks.
* All women will be diagnosed by the physician as postnatal low back pain.

Exclusion Criteria:

* Spinal fracture or any other neurological disorders.
* Lumbar disc herniation or degenerative disc disease
* Lumbar spinal stenosis from lumbar disc herniation, degenerative joint disease, or spondylolisthesis
* Women with BMI exceed 30 kg/m2.
* Patients who have polyneuropathy or other neurological disorders.
* Skin disease interferes with kinesiotape or myofascial release application.

Primary outcomes:
measure: Pain intensity level
timeFrame: 4 weeks
Secondary outcomes:
measure: Lumbar flexion range of motion
timeFrame: 4 weeks
measure: Lumbar extension range of motion
timeFrame: 4 weeks
measure: Lumbar lateral flexion range of motion
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Mahmoud Ahmed Mahmoud
Study officials:
affiliation: Cairo University
name: Afaf M Botla, Professor
role: STUDY_DIRECTOR
affiliation: Cairo University
name: Mohamed Awad, Professor
role: STUDY_CHAIR
References:
Clinical trial NCT01034943: Extraarticular Distal Radius Fractures, X-fix or Volar Fixation
Official title: Dorsally Displaced Extraarticular Distal Radius Fractures - Volar Plate or External Fixation. A Prospective Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dorsally Displaced Intraarticular Distal Radius Fractures
Age 50 - 74 for Females or 60-74 for Males
Low Energy Trauma
Keywords: radius
fracture
wrist
external
fixation
volar
plate
DASH
PRWE
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
First posted: 2009-12-18
Enrollment: 70
Sex: ALL
Minimum age (years): 50
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Distal radius fractures are treated surgically if severely displaced. This study aims to investigate the outcome after surgery. The investigators will randomize patients to either external fixation with optional addition of k-wires or open reduction and fixation with a volar plate.

Detailed description: This study has been merged with study NCT01035359 and a new ethical permission has been granted by the Swedish National Ethic board

Eligibility criteria: Inclusion Criteria:

* Female 50-74 years or male 60-74 years
* Dorsally displaced extraarticular distal radius fracture
* Dorsal angulation \>20 degrees measured from the plane perpendicular to the radius axis
* Low energy trauma
* Injury \<72 hours when diagnosed
* Patient independent of help for ADL

Exclusion Criteria:

* Earlier dysfunction in any wrist
* Other major injuries
* Rheumatoid arthritis or other systemic joint disease
* Dementia or severe psychiatric disease
* Severe medical condition making general anesthesia a considerable risk

Primary outcomes:
measure: The primary outcome is measured by DASH (Disability of the Arm, Shoulder and Hand), which is a self administered questionnaire validated for disease and dysfunction of the upper limb.
timeFrame: 12 months
Secondary outcomes:
measure: A secondary outcome measure is the degree of malalignment on the x-ray of the injured wrist.
timeFrame: 12 months
measure: A secondary outcome measure for this study is the EQ5D, a validated quality-of-life instrument.
timeFrame: 12 months
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Stockholm South Hospital Department of Orthopeadic Surgery
Study officials:
affiliation: Karolinska Institutet
name: Sari Ponzer, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06939543: The Test of Those Managing Pain With Their Own Pain
Official title: The Test of Those Managing Pain With Their Own Pain" - A Questionnaire-Based Study on Pain Perception and Patient Empathy Among Physicians Actively Managing Pain
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Empathy
Lead sponsor: Haseki Training and Research Hospital
Sponsor class: OTHER
First posted: 2025-04-23
Enrollment: 175
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Physicians working in anesthesiology, algology, intensive care, neurology, and physical therapy.

Brief summary: The study aims primarily to investigate physicians' awareness of their health status, empathy towards patients, and management processes through a questionnaire targeting physicians who diagnose and manage patients' pain.


Eligibility criteria: Inclusion Criteria:

* Specialist physicians actively working in pain treatment and management (e.g., Algology, Physical Medicine and Rehabilitation, Anesthesiology, Neurology, Rheumatology, etc.) or physicians currently undergoing specialty training in these areas.
* Physicians who volunteer to participate in the study and sign the informed consent form.
* Physicians who have actively followed up patients and applied pain management techniques within the last year.

Exclusion Criteria:

* Physicians who are not actively involved in pain management or who specialize in different medical fields.
* Physicians who do not wish to complete the questionnaire or do not provide voluntary consent.
* Physicians who complete the questionnaire incompletely or invalidly during the study.

Primary outcomes:
measure: pain questionnaire
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Ruscheweyh R, Marziniak M, Stumpenhorst F, Reinholz J, Knecht S. Pain sensitivity can be assessed by self-rating: Development and validation of the Pain Sensitivity Questionnaire. Pain. 2009 Nov;146(1-2):65-74. doi: 10.1016/j.pain.2009.06.020. Epub 2009 Aug 7.
citation: Licciardone JC, Tran Y, Ngo K, Toledo D, Peddireddy N, Aryal S. Physician Empathy and Chronic Pain Outcomes. JAMA Netw Open. 2024 Apr 1;7(4):e246026. doi: 10.1001/jamanetworkopen.2024.6026.
Clinical trial NCT04645043: Ultrasound Guided Esophageal Pressure
Official title: The Effect of Real Time Ultrasound Guided Esophageal Pressure on Preventing Gastric Insufflation in Infants and Children: an Exploratory Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aspiration
Infant Conditions
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2020-11-25
Enrollment: 50
Sex: ALL
Maximum age (years): 2
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The investigator aimed to evaluate the effect of ultrasound guided esophageal pressure on the incidence of gastric insufflation during anesthetic induction in infants and small children undergoing general anesthesia.

Detailed description: effect of ultrasound guided esophageal pressure on the incidence of gastric insufflation in children

Eligibility criteria: Inclusion Criteria:

* patients undergoing general anesthesia with endotracheal intubation

Exclusion Criteria:

* patients with hypertrophic pyloric stenosis
* patients with delayed gastric emptying
* patients with esophageal stenosis
* patients with at risk of gastric aspiration
* patients with ileus, hepatomegaly, ascites (cannot visualize gastric antrum with ultrasound)

Primary outcomes:
measure: the incidence of gastric air insufflation
timeFrame: during face mask ventilation, maximum 3 minutes.
Secondary outcomes:
measure: Gastric insufflation detected by esophageal ultrasound
timeFrame: during face mask ventilation, maximum 3 minutes.
measure: ventilatory parameters
timeFrame: during face mask ventilation, maximum 3 minutes.
measure: POGO (percentage of glottic opening) score
timeFrame: during endotracheal intubation, maximum 3 minutes
measure: relative position of esophagus with trachea
timeFrame: during anesthetic induction, maximal 3 minutes
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Hee-Soo Kim
state: Soul-t'ukpyolsi
Study officials:
References:
citation: Kim EH, Cho SA, Kang P, Song IS, Ji SH, Jang YE, Lee JH, Kim JT, Kim HS. Ultrasound-guided esophageal compression during mask ventilation in small children: a prospective observational study. BMC Anesthesiol. 2022 Aug 15;22(1):257. doi: 10.1186/s12871-022-01803-5.
Clinical trial NCT00921843: Methadone in Pediatric Anesthesia
Official title: Methadone in Pediatric Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Anesthesia
Keywords: Pediatric patients undergoing surgery
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2009-06-16
Enrollment: 61
Sex: ALL
Minimum age (years): 5
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will determine the pharmacokinetics of intravenous (IV) methadone in children undergoing surgery.


Eligibility criteria: Inclusion Criteria:

* Age 5-18
* Undergoing General anesthesia and surgery with anticipated postoperative inpatient stay of greater than or equal to 3 days
* Signed, written, informed consent from legal guardians and assent from patient

Exclusion Criteria:

* History of or known liver or kidney disease

Primary outcomes:
measure: R-methadone Plasma AUC 0-96hr/Dose
timeFrame: 96 hr
Secondary outcomes:
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
Study officials:
affiliation: Washington University School of Medicine
name: Evan Kharasch, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: