Clinical trial NCT02001038: Survey of Current Management of Orthopaedic Complications in CMT Patients
Official title: Survey of Current Management of Orthopaedic Complications in Charcot Marie Tooth Disease Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Charcot-Marie-Tooth Disease
Lead sponsor: University College London Hospitals
Sponsor class: OTHER
Collaborators: name: National Hospital for Neurology and Neurosurgery, London
name: University of Iowa
name: Children's Hospital of Philadelphia
name: University of Pennsylvania
name: University of Rochester
name: Dubowitz Neuromuscular Centre
name: Sydney Children's Hospitals Network
name: Carlo Besta Neurological Institute
name: Johns Hopkins University
name: Vanderbilt University
name: University of Washington
name: National Institutes of Health (NIH)
name: Stanford University
name: Data Management and Coordinating Center (DMCC)
name: Federal, State foundation and industry support: National Institute of Health (NIH), Muscular Dystrophy Association, Charcot Marie Tooth Association
First posted: 2013-12-04
Enrollment: 16
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Orthopaedic surgeons who perform surgical procedures for foot deformities in CMT patients attending centres participating in INC.

Brief summary: Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy. Foot deformities are frequent complications in CMT patients and orthopaedic surgery is often required. As yet there are no systematic studies on the management of orthopaedic complications in CMT patients and the current approach varies between centres. This study is a survey with the aim of understanding the current surgical approach to orthopaedic complications in CMT.

The target population includes orthopaedic surgeons who perform surgical procedures for foot deformities in CMT patients attending centres participating in the Inherited Neuropathies Consortium (INC).

Detailed description: The study protocol consists of a survey addressed to orthopaedic surgeons. The survey will be completed once and it includes two different scenarios of typical CMT patients (one adult and one child).

The orthopaedic surgeons will be asked which surgical procedures they would apply to each scenario:

* forefoot cavus,
* clawtoes and
* hindfoot varus

No medications or therapeutic agents are a component of this project.

Eligibility criteria: Inclusion Criteria:

* Orthopaedic surgeons who perform surgical procedures for foot deformities in CMT patients attending centres participating in the Inherited Neuropatheis Consortium (INC)
* Willing to complete survey

Exclusion Criteria:

* Does not read or speak English
* Inability to provide informed consent

Primary outcomes:
measure: Procedural correlations among orthopaedic surgeons on management of foot deformities in CMT patients
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: National Hospital for Neurology and Neurosurgery
Study officials:
affiliation: National Hospital for Neurology and Neurosurgery
name: Prof Mary Reilly
role: STUDY_CHAIR
References: