Clinical trial NCT05597579: Cognitive Impairments in Psychotic Disorders
Official title: The Timing of Cognitive Impairments in Psychotic Disorders
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Psychotic Disorders
Cognitive Impairment
Keywords: Schizophrenia
Affective Disorders
IQ Tests
Psychotic Disorders
Cognition
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2022-10-28
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The investigators will recruit patients treated in the psychiatric unit at the Sheba Medical Center and in other medical institutions throughout the country. Additionally, subjects will be recruited through internet advertisement of the study. All subjects will give informed consent.

Control group will be recruited by matching for Age, Sex and socioeconomic status. recruitment will be preforemd by advertisement.

Brief summary: Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first psychotic break is unclear. While there are data by several groups, showing that many future patients have significant cognitive impairments years before the onset of psychosis, many future patients seem to be doing well before the manifestation of psychosis, and decline steeply in functioning after their first psychotic episode. Hence the timing of the onset of cognitive impairment in patients with psychotic disorders requires further exploration. The current study will investigate the timing of cognitive impairment by using IQ tests before and after the first psychotic break

Detailed description: In this study the investigators aim to use the DAPAR tests (A cognitive assessment which all 17 year old Jewish adolescents in Israel undergo to participate in mandatory military service), which measures intelligence, and is equivalent to the IQ test. The subjects will be persons who had their first psychotic break, at least one year following the DAPAR tests. As part of the study, the participants will re-take the DAPAR tests, after the onset of the psychotic illness.

Eligibility criteria: Inclusion Criteria - Study Group:

* Patients between the ages 27-18 who had first psychotic break in the last ten years, and more than a year from the date of the DAPAR tests.
* Diagnoses of schizophrenia, Bipolar disorder or Schizoaffective disorder according to DSM-5 criteria.
* Previous DAPAR tests at the age of 17.

Inclusion Criteria - Control group:

* Participants between the ages of 27-18.
* No history of psychotic break.
* Previous DAPAR tests at the age of 17.

Exclusion Criteria - Both groups:

* Participants who did not perform the full battery of the DAPAR tests.
* Participants who have been appointed a guardian.

Exclusion Criteria - Control group:

- Participants who have a first-degree relative who suffers from a psychotic disorder.

Primary outcomes:
measure: Changes in DAPAR (An Israeli cognitive test) scores
timeFrame: 1 day (During recruitment visit)
Secondary outcomes:
measure: Psychotic Symptoms
timeFrame: 1 day (During recruitment visit)
measure: Social Functioning
timeFrame: 1 day (During recruitment visit)
measure: Cognitive Functioning
timeFrame: 1 day (During recruitment visit)
measure: Coping strategies
timeFrame: 1 day (During recruitment visit)
Other outcomes:
Locations:
city: Ramat-Gan
country: Israel
facility: Sheba Medical Center
Study officials:
affiliation: Sheba Medical Center
name: Mark Weiser, MD
role: PRINCIPAL_INVESTIGATOR
References: