Clinical trial NCT03275779: Investigating the Role of Resistance Exercise Frequency in the Regulation of Skeletal Muscle Mass
Official title: Investigating the Role of Resistance Exercise Frequency in the Regulation of Skeletal Muscle Mass
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physical Activity
Lead sponsor: University of Birmingham
Sponsor class: OTHER
Collaborators: name: Maastricht University
First posted: 2017-09-08
Enrollment: 9
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study will investigate whether manipulating resistance exercise frequency impacts muscle protein synthesis rates. The investigators will test the hypothesise that a higher resistance exercise frequency will result in greater muscle protein synthesis rates than a lower resistance exercise frequency.

Detailed description: Resistance exercise is currently the most effective means of building or maintaining muscle mass. Resistance exercise guidelines generally suggest that those looking to increase muscle mass should train each muscle group once to twice per week. However, it has been proposed that it may be of greater benefit to train a muscle group with a higher frequency (i.e., four to six times per week) than currently suggested. If true, completing the same total volume of resistance exercise in more frequent, smaller bouts could prove to be a more beneficial strategy to optimally build or maintain muscle mass.

Therefore, this study will investigate whether manipulating resistance exercise frequency impacts cumulative muscle protein synthesis rates in young individuals. Participants will undergo a 7 day period of habitual activity before completing the same total volume of resistance exercise as either; i) one isolated bout (low frequency) or ii) five smaller bouts (high frequency) over a period of 7 days.

Eligibility criteria: Inclusion Criteria:

* Body mass index (18.5-29.99 kg/m2)
* Untrained - defined as: Perform activities of daily living and recreation but have completed no regular lower body resistance-type exercise (e.g., weight training) activity in the last year.
* Good general health

Exclusion Criteria:

* Lidocaine allergy
* Hypertension (≥140/90 mmHg)
* Current participation in another clinical study
* Previous participation in this study
* Bleeding disorder/s
* Current or recent smoker
* Vegetarian or vegan
* Past history of substance abuse and/or taking prescription or non-prescription medication (e.g., beta-blockers, insulin or thyroxine) or supplements that may influence normal metabolic responses.

Primary outcomes:
measure: Change in muscle protein synthesis (FSR %/day)
timeFrame: At day 10 and 15.
Secondary outcomes:
measure: Change in satellite cell response
timeFrame: At day 10 and 15.
Other outcomes:
Locations:
city: Birmingham
country: United Kingdom
facility: School of Sport Exercise and Rehabilitation Sciences, University of Birmingham
state: West Midlands
Study officials:
affiliation: University of Birmingham
name: Gareth Wallis, PhD
role: PRINCIPAL_INVESTIGATOR
References: