Clinical trial NCT06413472: Comparing Mechanical Power in Different Inspiratory Times
Official title: Comparing Mechanical Power Values Using Geometric Methods at Different Inspiratory Rise and Pause Times: A Validation Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ventilator-Induced Lung Injury
Acute Respiratory Distress Syndrome
Lead sponsor: Başakşehir Çam & Sakura City Hospital
Sponsor class: OTHER_GOV
Collaborators: name: SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi
First posted: 2024-05-14
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: "Patients with a diagnosis of ARDS in the general intensive care unit of the Anesthesiology and Reanimation Clinic at Bakırköy Dr. Sadi Konuk Training and Research Hospital."

Brief summary: We aimed to compare mechanical power and energy values using geometric methods at varying inspiratory rise times.

Detailed description: In this study, the researchers aim to compare the mechanical power and energy values calculated using the geometric method in Volume-Controlled Ventilation (VCV) and Pressure-Controlled Ventilation (PCV) modes at different inspiratory rise times.

Eligibility criteria: Inclusion Criteria:

* ARDS (Acute Respiratory Distress Syndrome) patients.
* Patients who are deeply sedated.
* Patients ventilated in:
* Pressure-Controlled Ventilation (PCV or PRVC) mode, or
* Volume-Controlled Ventilation (VCV) mode.
* Patients within the 24-48 hour period of their stay in the intensive care unit.

Exclusion Criteria:

* Patients with incomplete data.
* Patients diagnosed with:
* COPD (Chronic Obstructive Pulmonary Disease),
* Heart failure.
* Pregnant patients.
* Patients with a thoracopleural fistula.
* Hemodynamically unstable patients.

Primary outcomes:
measure: MPgeo
timeFrame: 40 minute
measure: Energy
timeFrame: 40 minute
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Basaksehir Cam Sakura City Hospital
Study officials:
References:
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citation: Chi Y, He H, Long Y. A simple method of mechanical power calculation: using mean airway pressure to replace plateau pressure. J Clin Monit Comput. 2021 Oct;35(5):1139-1147. doi: 10.1007/s10877-020-00575-y. Epub 2020 Aug 11.
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citation: Asar S, Acicbe O, Sabaz MS, Kucur Tulubas E, Hergunsel GO, Cukurova Z, Canan E, Cakar N. Simplified calculation of mechanical power for pressure controlled ventilation in Covid-19 ARDS patients. Minerva Anestesiol. 2022 Jan-Feb;88(1-2):42-50. doi: 10.23736/S0375-9393.21.15741-4.
citation: Acicbe O, Ozgur CY, Rahimi P, Canan E, Asar S, Cukurova Z. The effect of inspiratory rise time on mechanical power calculations in pressure control ventilation: dynamic approach. Intensive Care Med Exp. 2023 Dec 20;11(1):98. doi: 10.1186/s40635-023-00584-6.
citation: ARDS Definition Task Force; Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012 Jun 20;307(23):2526-33. doi: 10.1001/jama.2012.5669.