Clinical trial NCT05188755: Fitness Assessment in Young Adults Recovered From Lymphoma
Official title: Fitness Assessment in Young Adults Recovered From Lymphoma or Hodgkin's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Young Adults
Lymphoma, Non-Hodgkin
Hodgkin Disease
Keywords: physical fitness
fat oxidation
metabolism
exercise
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2022-01-12
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: group 1: healthy controls group 2 : young adults recovered from lymphoma or Hodgkin's disease
Primary purpose: DIAGNOSTIC

Brief summary: Regular physical activity (PA) is associated with maintaining body composition, increased cardiorespiratory capacity, muscle mass and bone mineral density. In the event of a cancer, the development of physical capacities and metabolism may therefore be disturbed by cancer, these associated treatments (chemotherapy, radiotherapy and hematopoietic stem cell transplantation) but also undernutrition and the reduction in physical activity or even a sedentary lifestyle.

Although the benefits of PA in oncology are now well identified for adult populations, studies are still rare in the population of children, adolescents and young adults, and the results are still difficult to generalize. As a result, there is no recommendation on the practice of physical activity in pediatric oncology or adolescents and young adults and the levels of physical activity of cured patients remain lower than those of the general population.

Fitness is a marker of health in adults as well as in adolescents. Physical condition is a set of components such as cardiorespiratory capacity (transport and use of O2), body composition (distribution of bone, muscle and fat masses) and muscle function (strength, power, fatigue, energy metabolism) .

The investigators hypothesize that, compared to young adults, recovered from lymphoma are expected to exhibit impaired physical condition, due to physical deconditioning.


Eligibility criteria: Inclusion Criteria:

* Young adult male or female, aged 18 to 25
* giving free and informed consent
* Hodgkin lymphoma or non-Hodgkin lymphoma in the healing stage
* Cured (defined by an undetectable disease at the end of treatment) for at least one year and maximum 6 years of lymphoma or Hodgkin's disease

Exclusion Criteria:

* Legal incapable adults
* People under judicial protection
* Treatment with systemic glucocorticoids for more than a week, during the 30 days preceding the tests
* Medical contraindication to the practice of physical exercise
* Any pathologies (other than the history of lymphoma for the cases) likely to affect the metabolism or the muscle mass
* Any treatment that may have an influence on the energy metabolism
* Active infection
* Pregnant, breastfeeding, or likely to be
* Subject's refusal to participate

Primary outcomes:
measure: fat oxidation rate
timeFrame: day at 11:30 am during one day
Secondary outcomes:
measure: rest metabolism
timeFrame: at 08:00 am in fasted condition during one day
measure: blood insulinemia
timeFrame: at 07:30 am in fasted condition during one day
measure: blood N-terminal pro-B natriuretic peptide
timeFrame: at 07:30 am in fasted condition during one day
measure: blood troponin
timeFrame: at 07:30 am in fasted condition during one day
measure: blood lipids
timeFrame: at 07:30 am in fasted condition during one day
measure: blood glucose
timeFrame: at 07:30 am in fasted condition during one day
measure: Body composition: fat
timeFrame: at 07:30 am during one day
measure: Body composition: lean mass
timeFrame: at 07:30 am during one day
measure: cardiac output
timeFrame: at 11:30 am during one day
measure: peripheral quantitative computed tomography
timeFrame: at 10:45 am during one day
measure: physical condition
timeFrame: at 08:45 am during one day
measure: physical capacity
timeFrame: at 08:45 am during one day
measure: physical activity level
timeFrame: from day 2 to day 5
measure: sedentary level
timeFrame: from day 2 to day 5
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU de Clermont-Ferrand
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Justina Kanold
role: PRINCIPAL_INVESTIGATOR
References: