Clinical trial NCT03128684: The Effects of Lentil-containing Food Products on Satiety and Food Intake
Official title: The Effects of Lentil-containing Food Products on Satiety and Food Intake in Healthy Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Appetite
Satiety
Food Intake
Keywords: lentils
satiety
appetite
food intake
24-hour energy intake
Lead sponsor: University of Guelph
Sponsor class: OTHER
Collaborators: name: Agriculture and Agri-Food Canada
name: Saskatchewan Pulse Growers
name: Pulse Canada
First posted: 2017-04-25
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: The Lentil Satiety study will examine the effects of replacing wheat and rice with two types of lentils within food products (muffins and chilies) on satiety and food intake in healthy adults.

Detailed description: The Lentil Satiety study will examine the effects of replacing wheat and rice with two types of lentils (small green Eston and red split) within food products (muffins and chilies) on satiety and food intake in healthy adults, for a total of 6 study treatments. A total of 3 to 6 study visits (corresponding to consuming all muffins and/or all chilies) will take place where participants will consume one of the study treatments and subsequently complete satiety questionnaires over 180 minutes to measure satiety as subjective appetite sensations (hunger, fullness, desire to eat, and prospective food consumption). At 180 minutes, participants will receive ad libitum pizza and bottled water to consume until they are comfortably full for a measure of weighed food intake. At the end of each study visit, participants will be given a food scale and instructed to weigh and record all food and drink consumed for the remainder of the day for a measure of 24-hour energy intake.

Eligibility criteria: Inclusion Criteria:

* Healthy males and females
* Age 18 to 40 years old
* BMI 20-30 kg/m2

Exclusion Criteria:

* Blood pressure greater than 140/90 mmHg
* Major medical condition including a history of AIDS or hepatitis
* Medical or surgical event requiring hospitalization within 3 months of randomization
* Any medication use except stable dose (3 months) of oral contraceptives, blood pressure or statin medications
* Tobacco use
* Probiotic supplement use
* Dietary fibre supplement use
* Natural health products (NHPs) used for glycemic control (all other NHPs are ok, as long as stable for 3 months)
* Pulse consumption greater than 4 servings per week
* Food allergy or non-food life threatening allergy
* Pregnant or breastfeeding
* Alcohol consumption of greater than 14 drinks per week or greater than 4 drinks per sitting
* Recent or intended significant weight loss or gain (greater than 4kg in previous 3 months)
* Elite athletes
* Shift workers
* Breakfast skippers
* Score greater than 11, 9, or 8 on the Three Factor Eating Questionnaire (TFEQ) Cognitive Restraint, Disinhibition, and Hunger scales, respectively
* Dislike of frozen pizza

Primary outcomes:
measure: Satiety
timeFrame: Acute: 0, 15, 30, 45, 60, 90, 120, 150, and 180 minutes after treatment consumption
measure: Food Intake
timeFrame: Acute: 180 minutes following consumption of treatment
Secondary outcomes:
measure: 24-hour Energy Intake
timeFrame: Acute: 24 hours
Other outcomes:
Locations:
city: Guelph
country: Canada
facility: Human Nutraceutical Research Unit
state: Ontario
Study officials:
References:
citation: Clark SL, Ramdath DD, King BV, O'Connor KE, Aliani M, Hawke A, Duncan AM. Food Type and Lentil Variety Affect Satiety Responses but Not Food Intake in Healthy Adults When Lentils Are Substituted for Commonly Consumed Carbohydrates. J Nutr. 2019 Jul 1;149(7):1180-1188. doi: 10.1093/jn/nxz050.