Clinical trial NCT04618302: Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise
Official title: Test-retest Reliability of Lung Diffusing Capacity for Nitric Oxide During Light and Moderate Intensity Cycling Exercise
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: lung diffusing capacity for nitric oxide
lung function testing
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2020-11-05
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Healthy people without chronic cardiopulmonary diseases will be invited to participate in this study.

Brief summary: This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.

Detailed description: The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.

Eligibility criteria: Inclusion Criteria:

* Healthy
* Age 18 yrs and older
* Ability to follow study procedures and instructions in German

Exclusion Criteria:

* Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc)
* Obesity (BMI \> 30kg/m2)
* Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination)
* Mental impairment leading to inability to cooperate
* Respiratory infection in the last two weeks
* Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio \< lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.

Primary outcomes:
measure: Diffusing capacity for nitric oxide (DLNO)
timeFrame: At second study visit
measure: Diffusing capacity for nitric oxide (DLNO)
timeFrame: At third study visit, approximately 1-2 weeks after second study visit
Secondary outcomes:
measure: Diffusing capacity for nitric oxide (DLNO)
timeFrame: At second study visit
measure: Diffusing capacity for nitric oxide (DLNO)
timeFrame: At third study visit, approximately 1-2 weeks after second study visit
measure: Diffusing capacity for carbon monoxide (DLCO)
timeFrame: At second study visit
measure: Diffusing capacity for carbon monoxide (DLCO)
timeFrame: At third study visit, approximately 1-2 weeks after second study visit
measure: Diffusing capacity for carbon monoxide (DLCO)
timeFrame: At second study visit
measure: Diffusing capacity for carbon monoxide (DLCO)
timeFrame: At third study visit, approximately 1-2 weeks after second study visit
measure: Alveolar volume (VA)
timeFrame: At second study visit
measure: Alveolar volume (VA)
timeFrame: At third study visit, approximately 1-2 weeks after second study visit
measure: Alveolar volume (VA)
timeFrame: At second study visit
measure: Alveolar volume (VA)
timeFrame: At third study visit, approximately 1-2 weeks after second study visit
measure: Breath hold time (BHT)
timeFrame: At second study visit
measure: Breath hold time (BHT)
timeFrame: At third study visit, approximately 1-2 weeks after second study visit
measure: Breath hold time (BHT)
timeFrame: At second study visit
measure: Breath hold time (BHT)
timeFrame: At third study visit, approximately 1-2 weeks after second study visit
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: University of Zurich and University Hospital of Zurich
Study officials:
affiliation: University of Zurich and University Hospital Zurich
name: Thomas Radtke, PhD
role: PRINCIPAL_INVESTIGATOR
References: