louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00494403: Chronic Ankle Instability and Proprioception
Official title: Effects of Ankle Instability on Cervical Proprioception
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Ankle Sprains
Keywords: sprain proprioception
Lead sponsor: Logan College of Chiropractic
Sponsor class: OTHER
First posted: 2007-06-29
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cohort of college aged students with a history of ankle sprains.

Brief summary: The purpose of this investigation is to determine the effects of chronic ankle instability on cervical spine and knee proprioception as measured using joint position sense to investigate whether correlation can be drawn between the two.


Eligibility criteria: Inclusion Criteria:

* History of ankle instability
* Ages 20-65 yoa Exclusion Criteria: - Recent surgery, have any unstable or fused joints of the cervical spine.
* Medications, prescription or herbal muscle stimulants, relaxants.
* Any previ

Primary outcomes:
measure: joint repositioning error
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: St. Louis
country: United States
facility: Logan University, College of Chiropractic
state: Missouri
Study officials:
References:
Clinical trial NCT01340703: Vitrectomy for Optic Disc Pit Maculopathy
Official title: Vitrectomy Without Laser or Gas Tamponade for Optic Disc Pit Maculopathy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Optic Disc Pit Maculopathy
Keywords: optic disc pit
retinal detachment
retinoschisis
vitrectomy
posterior vitreous detachment
Lead sponsor: Kyorin University
Sponsor class: OTHER
First posted: 2011-04-22
Enrollment: 8
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy of vitrectomy, without gas tamponade or laser photocoagulation to the margin of the optic nerve, for the treatment of macular detachment associated with optic disc pits and to characterize retinal manifestations during treatment of optic pit maculopathy using optical coherence tomography (OCT). Vitrectomy with induction of a PVD at the optic disc without gas tamponade or laser photocoagulation appears to be an effective method of managing macular detachment due to optic disc pits. OCT scanning pre- and postoperatively suggests that peripapillary vitreous traction with the passage of fluid into the retina through the pit is the cause of the schisis-like separation seen in optic disc pit maculopathy.


Eligibility criteria: Inclusion Criteria:

* eyes with optic disc pit maculopathy

Exclusion Criteria:

* eyes without macular elevation associated with optic disc pit

Primary outcomes:
measure: anatomical result
timeFrame: one year
Secondary outcomes:
measure: visual acuity
timeFrame: one year
Other outcomes:
Locations:
city: Mitaka
country: Japan
facility: Kyroin University Eye Center
state: Tokyo
Study officials:
affiliation: Kyroin University
name: Akito Hirakata, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02345603: Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy
Official title: Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy During Open Surgery for Aortic Aneurysm
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Hypertension
Lead sponsor: University Hospital, Linkoeping
Sponsor class: OTHER
First posted: 2015-01-26
Enrollment: 9
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Non-randomized study of 5 subjects that have been selected for prophylactic open surgery due to abdominal aortic aneurysm. During surgery the renal arteries are identified and subjected to about 60 seconds each of freezing by application of liquid nitrogen in dedicated catheters around the circumference of each artery. Another 5 patients that are not subjected to the freeze therapy serve as controls. Main outcome is change in ambulatory blood pressure levels.

Detailed description: Non-randomized study of 5 subjects that have been selected for prophylactic open surgery due to abdominal aortic aneurysm. During the surgery the renal arteries at both sides are identified and subjected to about 60 seconds each of freezing by application of liquid nitrogen in dedicated catheters around the circumference of each artery. Renal arterial blood flow is checked by Doppler after the freezing procedure, during the surgery. Another 5 patients that are not subjected to the freeze therapy serve as controls. Main outcome is change in 24h ambulatory blood pressure levels and of course safety parameters such as creatinine levels.

Eligibility criteria: Inclusion Criteria:

* planned prophylactic surgery for abdominal aortic aneurysm

Exclusion Criteria:

* hypotension,
* inability to understand study protocol

Primary outcomes:
measure: Blood pressure levels
timeFrame: 2 months
Secondary outcomes:
measure: Levels of epinephrine and nor-epinephrine in urine
timeFrame: before and 2 months after surgery
Other outcomes:
Locations:
city: Linkoping
country: Sweden
facility: University Hospital of Linkoping
Study officials:
References:
Clinical trial NCT02417103: Pretreatment of Patients Expecting Bariatric Surgery With the GLP-1 Analogon Liraglutid
Official title: Pretreatment of Patients Expecting Bariatric Surgery With the GLP-1 Analogon
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Obesity
Lead sponsor: Universitätsklinikum Hamburg-Eppendorf
Sponsor class: OTHER
First posted: 2015-04-15
Enrollment: 2
Sex: ALL
Minimum age (years): 18
Maximum age (years): 77
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to investigate the effect of the treatment with the GLP-1 Analogon Liraglutide on the lipid metabolism an inflammation in adipose tissue.

Detailed description: The aim of this study is to investigate the effect of the treatment with the GLP-1 Analogon Liraglutide on the lipid metabolism an inflammation in adipose tissue. As GLP-1 is presumed to improve insulin sensitivity and associated parameters the investigators hypothesize that this might be due to changes in lipid metabolism which might be involved in the regulation of insulin sensitivity. Therefore the investigators intend to investigate changes of metabolic pathways before and after treatment with the GLP-1 analog liraglutide that could play a crucial role in pathogenesis as well as regulation of insulin sensitivity and atherogenic dyslipidemia such as: de novo lipogenesis and reverse cholesterol transport

Eligibility criteria: Inclusion Criteria:

* BMI 35-55 Kg/m2
* Fasting Blood glucose \>140mg/dl
* Planned bariatric surgery
* Diabetic Medication (Metformin, Sulfonylurea, Insuline)

Exclusion Criteria:

* Known hypersensitivity against Liraglutid
* Pretreatment DPP-4 Inhibitors or GLP-1 Analogue the last 3 months
* HbA1c \>10%

Primary outcomes:
measure: weight reduction
timeFrame: 4 years
Secondary outcomes:
measure: GLP-1 Levels
timeFrame: 4 years
Other outcomes:
Locations:
city: Hamburg
country: Germany
facility: University Medical Center Hamburg
Study officials:
affiliation: Universitätsklinikum Hamburg-Eppendorf
name: Jens Aberle, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01316003: Distinction of Cone Outer Segment Tips by Spectral-Domain Optical Coherence Tomography in Normal Eyes
Official title: Distinction of Cone Outer Segment Tips by Spectral-Domain Optical Coherence Tomography in Normal Eyes
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: cone outer segment tips line
Optical coherence tomography
Lead sponsor: Kyorin University
Sponsor class: OTHER
First posted: 2011-03-16
Enrollment: 37
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Thirty-seven eyes of 37 individuals without eye diseases

Brief summary: The aim of this study is to investigate the incidence and possible causes of obscured or disrupted cone outer segment tips line at fovea in spectral-domain optical coherence tomography images of normal eyes.

Detailed description: Thirty-seven eyes of 37 individuals without eye diseases were included in this study. Optical Coherence Tomography (OCT) images were taken using Cirrus HD-OCT (Carl Zeiss Meditec) with 5 line raster and high-definition 5 line raster modes. Images with signal strength weaker than 5/10 were excluded. Distinction of COST line and the integrity of COST line, external limiting membrane, and the photoreceptor inner segment and outer segment junction at the fovea were recorded. Demographic data, refractive error of the eyes, signal strengths of the OCT images were acquired for analysis.

Eligibility criteria: Inclusion Criteria:

* individuals without eye diseases

Exclusion Criteria:

* individuals with eye diseases

Primary outcomes:
measure: Microstructural analysis by Spectral domain optical coherence tomography
timeFrame: one year
Secondary outcomes:
measure: Visual acuity
timeFrame: one year
Other outcomes:
Locations:
city: Mitaka
country: Japan
facility: Kyorin Eye Center
state: Tokyo
Study officials:
affiliation: Kyorin Eye Center
name: Makoto Inoue, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Rii T, Itoh Y, Inoue M, Hirakata A. Foveal cone outer segment tips line and disruption artifacts in spectral-domain optical coherence tomographic images of normal eyes. Am J Ophthalmol. 2012 Mar;153(3):524-529.e1. doi: 10.1016/j.ajo.2011.08.021. Epub 2011 Oct 21.
Clinical trial NCT06609603: Clinical Study to Evaluate the Body Fat Reducing Effects of Heat-Treated Green Tea Extract Complex
Official title: A Randomized, Double-blind, Placebo-controlled, Parallel-design Clinical Study to Evaluate the Body Fat Reducing Effect of Heat-Treated Green Tea Extract Complex
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Body Fat
Lead sponsor: Amorepacific Corporation
Sponsor class: INDUSTRY
First posted: 2024-09-24
Enrollment: 100
Sex: ALL
Minimum age (years): 19
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This clinical study was designed to evaluate the efficacy and safety of body fat reduction in obese adults by treatment of heat-treated green tea extract complex

Detailed description: This study is a 12-week, randomized, double-blind, placebo-controlled clinical trial. 100 subjects were ranromly assigned to heat-treated green tea extract(HTGT) group and placebo group. The changes in the efficacy endpoint were evaluated after treatment of 2 capsules of HTGT once daiy for 12 weeks.

Eligibility criteria: * lt;Inclusion Criteria\&gt;

  * Males and females aged between 19 \~ 64 years
  * BMI 25.0 \~ 34.9 kg/m\^2
  * Waist circumferebce: 90cm or more for men, 85cm or more for women
  * Subjects who have fully understand the information provided about the study and voluntarily decided to participate
* lt;Exclusion Criteria\&gt;

  * Participants whose weight changed by more than 10% within the 3 months prior to visit 1
  * Individuals participated in a commercial weight loss program within 3 months prior to Visit 1
  * Participants who have undergone surgical procedures within 3 years
  * Participants who have taken obesity treatment medications within the last 3 months
  * Individuals who have taken medications affecting weight or dietary supplements for weight control within the last month
  * Subjects with uncontrolled hypertension
  * Subjects diagnosed with diabetes
  * TSH \&lt;0.1 uIU/ml or \&gt;10 uIU/ml
  * Creatinine \&gt;1.5mg/dL
  * AST or ALT \&gt; three times the upper normal limit

Primary outcomes:
measure: Change of body fat by DEXA
timeFrame: Baseline, Week 12
Secondary outcomes:
measure: Changes of total abdominal fat area, visceral fat area and subcutaneous fat area
timeFrame: Baseline, Week 12
measure: Changes of indicator of lipid metabolism
timeFrame: Baseline, Week 12
measure: Changes of waist circumference
timeFrame: Baseline, Week 12
measure: Changes of blood biomarker
timeFrame: Baseline, Week 12
Other outcomes:
Locations:
city: Suwon
country: Korea, Republic of
facility: Catholic University St. Vincent Hospital
state: Gyeonggi-do
Study officials:
affiliation: Catholic University St. Vincent Hospital
name: Sang-Wook Song, M.D./Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03546803: 3M Cavilon Advanced Skin Protectant for the Prophylaxis of Radiation Dermatitis
Official title: Assessment of 3M Cavilon Advanced Skin Protectant for the Prophylaxis of Radiation Dermatitis in Cancer Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Radiation Dermatitis
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2018-06-06
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Radiation therapy patients

Brief summary: This study observes a liquid skin protectant that is a polymeric-cyanoacrylate solution designed to protect intact or damaged skin due to radiation.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18years.
* Patient has initial or recurrent disease
* Undergoing external beam radiotherapy at the Mayo Clinic Rochester campus Note: Patients who are undergoing concurrent chemotherapy are eligible
* Ability to complete questionnaire(s) by themselves or with assistance
* Provide informed written consent
* Willing to consent for photography of radiation field
* Available to return to Mayo Clinic in within 1 week post treatment for assessment (+/- 7 days).
* At risk for developing ≥ grade 2 dermatitis radiation as determined by treating Radiation Oncology clinician
* Biologic effective dose of \>42 Gy10 as calculated using the web site EQD2.com.

Exclusion Criteria:

* Unable to provide informed consent
* Patients with active rash, pre-existing dermatitis, lupus or scleroderma within the treatment area that may make skin assessment for the study difficult
* Known history of developing an allergic reaction after using a product containing cyanoacrylate or acrylates
* Subject has a medical condition that in the opinion of the investigator should exclude him/her from participating in the study
* Subject has been enrolled in an investigational study where product was applied to the proposed study site within 30 days of the screening visit
* The skin area affected by radiation requires treatment with a concomitant medication or product (if applicable)

Primary outcomes:
measure: compare radiation dermatitis severity
timeFrame: 3 months (+/- 1 month) following the completion of radiation therapy
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
References:
Clinical trial NCT04992403: Ocular Biometrics in a French Population
Official title: Ocular Biometric Measurements in Cataract Surgery Candidates in The South of France : a Multicenter Cross Sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cataract
Keywords: Biometry
Axial length
Cataract
Gender
High myopia
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2021-08-05
Enrollment: 11650
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who underwent ocular biometrics before cataract surgery

Brief summary: The investigators aimed to study ocular biometrics parameters and their association with age, gender and the prevalence of high myopia in a population of cataract surgery candidates in the South of France. The investigators also aimed to define proportion of an "usual eye" and know the rate of inhomogeneous eyes in our population.


Eligibility criteria: Inclusion criteria:

* aged 40 years
* olderpatients who underwent ocular biometrics before cataract surgery

Exclusion criteria: incomplete examination

* previous cataract surgery
* age \< 40 years

Primary outcomes:
measure: number of patients with Distribution of ocular biometrics
timeFrame: 1 day
Secondary outcomes:
measure: number of patients with Prevalence of high myopia
timeFrame: 1 day
measure: rate of inhomogeneous eyes
timeFrame: 1 day
Other outcomes:
Locations:
city: Montpellier
country: France
facility: UH Montpellier
Study officials:
affiliation: University Hospitals of Montpellier
name: Vincent DAIEN, MD, PhD, HDR
role: STUDY_DIRECTOR
References:
Clinical trial NCT04828603: Understanding Allergies and Sensitizations in Healthy and Allergic Individuals
Official title: Understanding Allergies
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Allergy
Lead sponsor: Stanford University
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
name: Crown Fundation
name: Sunshine Foundation
name: National Institute of Allergy and Infectious Diseases (NIAID)
name: National Human Genome Research Institute (NHGRI)
name: Harvard School of Public Health (HSPH)
First posted: 2021-04-02
Enrollment: 2500
Sex: ALL
Minimum age (years): 1
Maximum age (years): 90
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients ages 1 week through 90 years who have or are suspected of having allergic sensitivities will be invited to participate

Brief summary: The purpose of this study is to strengthen our ability to accurately diagnose allergies and understand cellular, humoral, genetic components and physiological changes in allergic disease


Eligibility criteria: Inclusion Criteria:

* Any individual with possible allergy

Exclusion Criteria:

* Patients with special risks attendant to venipuncture will be excluded

Primary outcomes:
measure: Skin testing to evaluate food allergen responses
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Sean N. Parker Center for Allergy and Asthma Research, Stanford University
state: California
Study officials:
affiliation: Stanford University
name: R. Sharon Chinthrajah, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05871203: Changes in Gene Expression and Prognosis of Blood Immune Cells After Cardiopulmonary Bypass Surgery
Official title: Changes in Gene Expression and Prognosis of Blood Immune Cells After Cardiopulmonary Bypass Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Kidney Injury
Keywords: Acute kidney injury
Cardiopulmonary bypass
gene expression
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2023-05-23
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients undergoing elective major cardiac surgery under cardiopulmonary bypass

Brief summary: The goal of this observational study is to learn about the changes in gene expression in blood immune cells in after cardiac surgery with cardiopulmonary bypass.The main question it aims to answer is: What specific gene expression changes predict kidney damage after cardiac surgery with cardiopulmonary bypass. Participants received conventional treatment.


Eligibility criteria: Inclusion Criteria:

* 1) Age≥ 18 years old; 2) Cardiopulmonary bypass descending valve replacement (molding), or coronary artery bypass grafting, or macrovascular surgery.

Exclusion Criteria:

* 1) any cognitive or mental impairment that is unable to sign the informed consent form; 2) Have basic immune system and blood system diseases; 3) pregnancy; 4) Receiving radiotherapy and chemotherapy before surgery; 5) Receiving immunosuppressive drugs within six months; 6) Have participated in other interventional clinical trials within 30 days before surgery.

Exit Criteria:

1. Incomplete surgery;
2. Secondary transfer in the operating room;
3. Automatically request to terminate the test.

Primary outcomes:
measure: Postoperative acute kidney injury
timeFrame: Within 48 hours after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: The Second Affiliated Hospital of Zhejiang University anesthesiology department
state: Zhejiang
Study officials:
References:
Clinical trial NCT00888303: Single Dose Steroid Before Thyroidectomy for Benign Disease to Improve Postoperative Nausea, Pain, and Vocal Function
Official title: Randomized Controlled Trial on Efficacy of Preemptive 8 mg of Dexamethasone for Reducing Pain and Postoperative Nausea and Vomit After Thyroidectomy for Benign Disease.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Postoperative Pain
Postoperative Nausea and Vomit
Postoperative Vocal Function
Thyroidectomy
Lead sponsor: Ospedale Misericordia e Dolce
Sponsor class: OTHER
First posted: 2009-04-27
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy of 8 mg of dexamethasone administered prior surgery, to reduce pain, postoperative nausea and vomiting and to improve vocal function after thyroidectomy for benign disease.


Eligibility criteria: Inclusion Criteria:

* Age \> 18 years
* Patients undergoing thyroidectomy

Exclusion Criteria:

* Patients who had received antiemetic therapy within 48 hours before surgery
* Patients with depression
* Chronic pain disorder
* Insulin-dependent diabetes mellitus
* History of severe and/or repeated PONV after previous minor surgery, that led to change from standard anesthetic protocol
* Pregnancy
* Age \< 18 years
* Patients who had known malignant disease or had undergone previous thyroid or neck surgery

Primary outcomes:
measure: Postoperative nausea and vomit (PONV) measured in 4 grades
timeFrame: 8, 24, 32 and 48 hours after surgery
Secondary outcomes:
measure: Postoperative pain after thyroidectomy measured in a 0-100 Visual analog scale
timeFrame: 8, 24, 32 and 48 hours after surgery
measure: Vocal function measured in a 0-100 Visual analog scale
timeFrame: 8, 24, 32 and 48 hours after surgery
Other outcomes:
Locations:
city: Prato
country: Italy
facility: Misericordia and Dolce Hodpital
state: Po
Study officials:
affiliation: Misericordia and Dolce Hospital
name: Marco Scatizzi, MD
role: STUDY_CHAIR
affiliation: Misericordia and Dolce Hospital
name: Marco Rettori, MD
role: STUDY_DIRECTOR
affiliation: Misericordia and Dolce Hospital
name: Francesco Feroci, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Worni M, Schudel HH, Seifert E, Inglin R, Hagemann M, Vorburger SA, Candinas D. Randomized controlled trial on single dose steroid before thyroidectomy for benign disease to improve postoperative nausea, pain, and vocal function. Ann Surg. 2008 Dec;248(6):1060-6. doi: 10.1097/SLA.0b013e31818c709a.