Clinical trial NCT04022564: Incidence, and Survival Medical Expenditure of Patients With Multiple Sclerosis
Official title: Incidence, and Survival Medical Expenditure of Patients With Multiple Sclerosis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Neurologic Signs and Symptoms
Keywords: multiple sclerosis
Survival Analysis
cause of death
medical resources
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2019-07-17
Enrollment: 2000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population is based on the 'National Health Insurance Research Database' (NHIRD) from 2001 to 2015 provided by Taiwan Ministry of Health and Welfare.

Brief summary: Multiple sclerosis (MS) is a disease of autoimmune system which attacks the central nervous system and that is one of the most common inflammatory diseases and has caused a heavy disease burden on patients. In the world, the prevalence of MS is on the rise, and the annual growth rate of MS patients in Taiwan is much higher than the whole world (3.78 times). However, it has no discussion or study in references at present, and it is worthwhile to research. MS is not a fatal disease, but its complications make the mortality of its patients three times higher than that of general population. This study will explore the survival and the causes of death for MS patients in Taiwan by cohort study of fourteen years. In addition, in the recent years, the MS patients in Taiwan and the medical resource consumption has increased largely, and it is necessary to conduct the research.

Detailed description: The study population is based on the 'National Health Insurance Research Database' (NHIRD) from 2001 to 2015 provided by Taiwan Ministry of Health and Welfare. The subjects are diagnosed as MS patients based on the 'Registry for Catastrophic Illness'. First, the investigators will perform the statistical analysis of the incidence, the prevalence, the mortality and the trend analysis of the MS patients diagnosed each year. First, Kaplan-Meier method will be employed to examine the survival curves. Next, Cox proportional hazards model will be used to analyze the survival and related factors. Last, multiple regression analysis will be then performed to analyze the influence of independent variables on patients' medical utilization in each year.

In response to the lack of data on population-based epidemiological studies on MS diseases in Asia, this research wishes to fill the gaps in the studies of global prevention and analyze the patient's survival, mortality risk factors and the medical utilization as a reference for national health policies.

Eligibility criteria: Inclusion Criteria:

* The subjects are diagnosed as MS patients

Exclusion Criteria:

* The subjects are not diagnosed as MS patients

Primary outcomes:
measure: Incidence, and SurvivalMedical Expenditure of Patients with Multiple Sclerosis
timeFrame: 'National Health Insurance Research Database' (NHIRD) from 2001 to 2015
Secondary outcomes:
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: Genetic and Rare Disease Center
Study officials:
References: