Clinical trial NCT06649084: Primary Progressive Aphasia Multicomponent Language Treatment Study
Official title: Establishing Evidence-based Multicomponent Treatment for Speech and Language in Primary Progressive Aphasia
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Primary Progressive Aphasia
Semantic Dementia
Semantic Memory Disorder
Logopenic Progressive Aphasia
Nonfluent Aphasia, Progressive
Aphasia
Aphasia, Progressive
Keywords: Speech-Language Pathology
Neurodegenerative Disease
Logopenic
Semantic
Nonfluent
Speech Entrainment
Telethearpy
Multimodal Communication Training
Partner Training
Augmentative and Alternative Communication
Script training
Lead sponsor: University of Texas at Austin
Sponsor class: OTHER
First posted: 2024-10-18
Enrollment: 21
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Primary progressive aphasia (PPA) is a progressive neurological disorder that causes a gradual decline in communication ability as a result of selective neurodegeneration of speech and language networks in the brain. PPA is a devastating condition affecting adults as young as in their 50's, depriving them of the ability to communicate and function in society. As a result of improved diagnostic precision, PPA is now identified with greater accuracy and frequency and, increasingly, patients and their families seek options for behavioral treatments to ameliorate the devastating effects on their communication, prolong speech language skills, and maximize quality of life. Speech-language treatment outcomes from our group and others are encouraging, confirming that behavioral intervention may lead to improvements in trained behaviors and, for some interventions, lasting and generalized benefit. Most speech-language interventions for individuals with PPA that have been explored in the literature are restitutive, or impairment-based in nature, and have not addressed the full range of severity and phenotypic variability in this population. The investigators will evaluate the utility of a novel, multicomponent intervention that incorporates elements of restitutive (e.g., word finding strategic training, script training), compensatory (e.g., multimodal communication, communication book), and care partner-focused treatment to meet the needs of individuals varying in clinical presentation and severity.


Eligibility criteria: Inclusion Criteria:

* Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
* Scores of 10 or higher on the Mini-Mental State Examination
* Has a study partner who can consistently attend sessions

Exclusion Criteria:

* Other neurological or psychiatric diagnosis that may contribute to cognitive-linguistic deficits
* Significant, uncorrected visual or hearing impairment that would interfere with participation
* Score of less than 10 on the Mini-Mental State Examination
* Prominent initial non-speech-language impairment (cognitive, behavioral, motoric)

Primary outcomes:
measure: Change in script production accuracy
timeFrame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
measure: Change in spoken naming of trained/untrained items
timeFrame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
measure: Information communicated in any modality for trained/untrained stimuli
timeFrame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
measure: Goal Attainment Score
timeFrame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Secondary outcomes:
measure: Change on Quick Aphasia Battery
timeFrame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
measure: Change on Aphasia Impact Questionnaire
timeFrame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Other outcomes:
measure: Post-treatment Communication Survey
timeFrame: post-treatment (approximately 6-12 weeks after treatment onset)
Locations:
city: Austin
country: United States
facility: University of Texas
state: Texas
Study officials:
affiliation: University of Texas - Austin
name: Maya L Henry, PhD
role: PRINCIPAL_INVESTIGATOR
References: