Clinical trial NCT04933110: Investigation of Hand Functions and Related Parameters in People With Multiple Sclerosis
Official title: Investigation of Hand Functions and Related Parameters in People With Multiple Sclerosis in the Very Early Stage.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Multiple Sclerosis
Keywords: multiple sclerosis
upper limb function
activity
participation
Lead sponsor: Istanbul Aydın University
Sponsor class: OTHER
Collaborators: name: Istanbul University - Cerrahpasa
First posted: 2021-06-21
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Individuals with MS who met the inclusion criteria and volunteered to participate in the study.

Volunteer healthy individuals of similar age and sex with individuals with MS.

Brief summary: The upper extremity in people with Multiple Sclerosis (pwMS) has become a more popular research topic in recent years, with the increase in studies reporting widespread involvement. The aim of our study was to evaluate the upper extremity from multiple perspectives in early stage pwMS, to identify problems by comparing them with healthy individuals, and to examine the relationship of problems with activity and participation.


Eligibility criteria: Inclusion Criteria:

* MS diagnosis according to McDonald criteria
* Relapsing Remitting MS clinical course type
* 18-65 age range
* Being able to understand and read Turkish

Exclusion Criteria:

* Having an MS attack in the last 3 months
* To have done regular exercise for the upper extremity in the 6 months before starting the study
* Having different neurological, orthopedic or cardiac problems other than MS
* Being addicted to alcohol or drugs
* Getting a score below 24 on the Mini Mental Test Scale
* Having a spasticity of 3 or more according to the Modified Ashworth Scale

Primary outcomes:
measure: Nine Hole Peg Test
timeFrame: baseline (on the predetermined assessment day)
measure: Minnesota Manual Dexterity Test
timeFrame: baseline (on the predetermined assessment day)
measure: ABILHAND
timeFrame: baseline (on the predetermined assessment day)
measure: Motor Activity Log-28
timeFrame: baseline (on the predetermined assessment day)
measure: Community Integration Questionnaire
timeFrame: baseline (on the predetermined assessment day)
Secondary outcomes:
measure: Hand Held Dynamometer
timeFrame: baseline (on the predetermined assessment day)
measure: Hand Dynamometer
timeFrame: baseline (on the predetermined assessment day)
measure: Pinchmeter
timeFrame: baseline (on the predetermined assessment day)
measure: Tuning fork
timeFrame: baseline (on the predetermined assessment day)
measure: Aesthesiometer
timeFrame: baseline (on the predetermined assessment day)
measure: Fatigue Severity Scale
timeFrame: baseline (on the predetermined assessment day)
measure: Symbol Digit Modalities Test
timeFrame: baseline (on the predetermined assessment day)
measure: Hospital Anxiety and Depression Scale
timeFrame: baseline (on the predetermined assessment day)
Other outcomes:
Locations:
Study officials:
References: