Clinical trial NCT04288284: Emergency Curative Resection of Colorectal Cancer
Official title: Emergency Curative Resection of Colorectal Cancer, Do it With Caution. A Comparative Case Series
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Colorectal Cancer
Oncologic Complications and Emergencies
Keywords: Complicated colorectal cancer
Curative resection
Surgical and oncologic outcomes
Lead sponsor: University of Alexandria
Sponsor class: OTHER
First posted: 2020-02-28
Enrollment: 215
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: This study included 60 consecutive patients presented by complicated colorectal cancer treated by emergency surgery at Alexandria University hospital between January 2015 and January 2017 (Group I). Another 155 patients with uncomplicated colorectal cancer treated by elective surgery during the same period were included (Group II).

Brief summary: The feasibility and efficacy of emergency curative resection of complicated colorectal cancer is still controversial. This prospective study aim is to assess surgical and oncologic outcomes after emergency compared to elective curative resection of colorectal cancer

Detailed description: 60 consecutive patients presented with complicated colorectal cancer managed by emergency surgery were included and compared to another 155 consecutive patients admitted during the same period with uncomplicated colorectal cancer managed by elective surgery. Both groups were compared regarding curative resection rate, early postoperative mortality and morbidity, 3-years tumor recurrence and survival rates.

Eligibility criteria: Inclusion Criteria:

* All patients presented with Potentially operable colorectal cancer
* No clinical or radiological evidence of metastatic disease

Exclusion Criteria:

* Patients received preoperative chemoradiation
* Patients with clinical or radiological evidence of metastatic disease
* Patients with intraoperative evidence of metastatic disease
* Patients with intraoperative evidence of irresectable disease
* Patients with incomplete follow up

Primary outcomes:
measure: Adequate oncologic resection
timeFrame: histopathological assessment of surgical specimens within 2 weeks postoperative
measure: early postoperative mortality after curative resection of colorectal cancer
timeFrame: within 90 days after surgery
measure: early postoperative morbidity after curative resection of colorectal cancer
timeFrame: within 90 days after surgery
Secondary outcomes:
measure: Tumor recurrence
timeFrame: By the end of the 3 years follow up period
measure: Disease free survival
timeFrame: By the end of the 3 years follow up period
measure: Overall survival
timeFrame: By the end of the 3 years follow up period
Other outcomes:
Locations:
Study officials:
affiliation: Ass. Professor of Surgery
name: Mohamed Elmessiry, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ghazi S, Berg E, Lindblom A, Lindforss U; Low-Risk Colorectal Cancer Study Group. Clinicopathological analysis of colorectal cancer: a comparison between emergency and elective surgical cases. World J Surg Oncol. 2013 Jun 11;11:133. doi: 10.1186/1477-7819-11-133.
citation: Biondo S, Marti-Rague J, Kreisler E, Pares D, Martin A, Navarro M, Pareja L, Jaurrieta E. A prospective study of outcomes of emergency and elective surgeries for complicated colonic cancer. Am J Surg. 2005 Apr;189(4):377-83. doi: 10.1016/j.amjsurg.2005.01.009.
citation: Kim J, Mittal R, Konyalian V, King J, Stamos MJ, Kumar RR. Outcome analysis of patients undergoing colorectal resection for emergent and elective indications. Am Surg. 2007 Oct;73(10):991-3.