Clinical trial NCT01457768: A Gilead Sequence Registry of Subjects Who Did Not Achieve Sustained Virologic Response
Official title: A Long Term Follow-up Registry Study of Subjects Who Did Not Achieve Sustained Virologic Response in Gilead-Sponsored Trials in Subjects With Chronic Hepatitis C Infection
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hepatitis C, Chronic
Keywords: Hepatitis C
HCV
Sustained Virologic Response
Direct Acting Antiviral
Combination Therapy
Tegobuvir
Registry
HCV RNA
Treatment experienced
Treatment naive
GS 9451
GS 5885
Sequence
GS 5816
GS 7977
Sofosbuvir
Sovaldi™
SOF
Ledipasvir
LDV
Lead sponsor: Gilead Sciences
Sponsor class: INDUSTRY
First posted: 2011-10-24
Enrollment: 570
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants who have failed to achieve sustained virologic response (SVR) while receiving at least one Gilead OAV in a previous Gilead-sponsored HCV study.

Brief summary: This Registry is designed to obtain long term data on participants who have failed to achieve sustained virologic response (SVR) while receiving at least one Gilead oral antiviral agent (OAV) in a previous Gilead-sponsored hepatitis C virus (HCV) study.


Eligibility criteria: Key Inclusion Criteria:

* Have previously participated in a Gilead-sponsored hepatitis C study and received at least one Gilead OAV
* Have failed to achieve an SVR in a previous Gilead-sponsored study, as defined in the original treatment protocol
* Provide written, informed consent
* Be willing and able to comply with the visit schedule

Key Exclusion Criteria:

* Individuals planning to start a new course of hepatitis C therapy including any investigational drug or device during the course of the follow-up Registry
* History of clinically significant illness or any other major medical disorder that may interfere with follow-up, assessments or compliance with the protocol

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Primary outcomes:
measure: Proportion of participants with at least one drug resistant mutation (DRM) loss from enrollment to end of study by treatment regimen
timeFrame: Up to 3 years
Secondary outcomes:
measure: Proportion of participants with DRM loss by unit category, 1, 2, 3,…n, by treatment regimen
timeFrame: Up to 3 years
measure: Average number of DRM loss by treatment regimen
timeFrame: Up to 3 years
measure: Liver disease progression
timeFrame: Up to 3 years
measure: Proportion of participants who develop hepatocellular carcinoma (HCC) through Week 144 by treatment regimen
timeFrame: Up to 144 weeks
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Birmingham Gastroenterology Associates
state: Alabama
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Dothan
country: United States
facility: Digestive Health Specialists
state: Alabama
city: Phoenix
country: United States
facility: Mayo Clinic
state: Arizona
city: Tucson
country: United States
facility: University of Arizona
state: Arizona
city: Anaheim
country: United States
facility: Advanced Clinical Research Institute, LLC
state: California
city: Bakersfield
country: United States
facility: Franco Felizarta, MD
state: California
city: Coronado
country: United States
facility: Southern California Medical Group
state: California
city: Costa Mesa
country: United States
facility: West Coast Clinical Trials, LLC
state: California
city: Davis
country: United States
facility: UC Davis Medical Center
state: California
city: La Jolla
country: United States
facility: Kaiser Permanente Institute for Health Research
state: California
city: La Jolla
country: United States
facility: Scripps Clinic
state: California
city: La Jolla
country: United States
facility: University of California San Diego
state: California
city: La Mesa
country: United States
facility: eStudySite
state: California
city: Long Beach
country: United States
facility: VA Long Beach Healthcare System
state: California
city: Los Angeles
country: United States
facility: Kaiser Permanente of Colorado
state: California
city: Los Angeles
country: United States
facility: Peter J. Ruane, MD, Inc.
state: California
city: Los Angeles
country: United States
facility: 8631 West 3rd Street
state: California
city: Los Angeles
country: United States
facility: California Liver Institute
state: California
city: Los Angeles
country: United States
facility: Anthony Mills MD, Inc
state: California
city: Los Angeles
country: United States
facility: Cedars-Sinai Medical Center
state: California
city: Los Angeles
country: United States
facility: Veterans Administration Wadsworth Medical Center
state: California
city: Oceanside
country: United States
facility: eStudySite
state: California
city: Palo Alto
country: United States
facility: Stanford University
state: California
city: Pasadena
country: United States
facility: 660 South Fair Oaks Avenue
state: California
city: Sacramento
country: United States
facility: UC Davis Medical Center
state: California
city: San Diego
country: United States
facility: University of California San Diego
state: California
city: San Diego
country: United States
facility: Research and Education, Inc.
state: California
city: San Diego
country: United States
facility: Medical Associates Research Group, Inc.
state: California
city: San Francisco
country: United States
facility: California Pacific Medical Center
state: California
city: San Francisco
country: United States
facility: Quest Clinical Research
state: California
city: San Francisco
country: United States
facility: University of California, San Francisco School of Medicine
state: California
city: San Francisco
country: United States
facility: San Francisco General Hospital
state: California
city: San Francisco
country: United States
facility: University of California San Francisco
state: California
city: San Jose
country: United States
facility: San Jose Gastroenterology
state: California
city: San Jose
country: United States
facility: Silicon Valley Research Institute
state: California
city: Torrance
country: United States
facility: Los Angeles BioMedical Institute at Harbor-UCLA Medical Center
state: California
city: Torrance
country: United States
facility: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
state: California
city: Aurora
country: United States
facility: University of Colorado
state: Colorado
city: Englewood
country: United States
facility: South Denver Gastroenterology
state: Colorado
city: New Haven
country: United States
facility: Yale University School of Medicine
state: Connecticut
city: Washington
country: United States
facility: Whitman Walker Clinic
state: District of Columbia
city: Washington
country: United States
facility: Capital Medical Associates, P.C.
state: District of Columbia
city: Bradenton
country: United States
facility: Pointe West Infectious Diseases d/b/a Bach and Godofsky Infectious Diseases
state: Florida
city: Gainesville
country: United States
facility: University of Florida
state: Florida
city: Miami
country: United States
facility: University of Miami Miller School of Medicine
state: Florida
city: New Port Richey
country: United States
facility: Advanced Research Institute
state: Florida
city: Orlando
country: United States
facility: Orlando Immunology Center-
state: Florida
city: Orlando
country: United States
facility: Internal Medicine Specialists
state: Florida
city: Orlando
country: United States
facility: Orlando Clinical Research Center
state: Florida
city: Tampa
country: United States
facility: St. Joseph's Comprehensive Research Institute
state: Florida
city: Tampa
country: United States
facility: Saint Joseph's Hospital
state: Florida
city: Tampa
country: United States
facility: Tampa General Hospital
state: Florida
city: Wellington
country: United States
facility: South Florida Center of Gastroenterology, P.A.
state: Florida
city: Atlanta
country: United States
facility: Atlanta Gastroenterology Associates
state: Georgia
city: Atlanta
country: United States
facility: Emory University
state: Georgia
city: Atlanta
country: United States
facility: Digestive Healthcare of Georgia
state: Georgia
city: Decatur
country: United States
facility: Infectious Disease Specialists of Atlanta
state: Georgia
city: Marietta
country: United States
facility: Gastrointestinal Specialists of Georgia, PC
state: Georgia
city: Chicago
country: United States
facility: University of Chicago
state: Illinois
city: Chicago
country: United States
facility: Medical College of Wisconsin
state: Illinois
city: Chicago
country: United States
facility: Northwestern Memorial Hospital
state: Illinois
city: Indianapolis
country: United States
facility: Indianapolis Gastroenterology Research Foundation
state: Indiana
city: Indianapolis
country: United States
facility: Indiana University School of Medicine
state: Indiana
city: Kansas City
country: United States
facility: University of Kansas Medical Center Research Institute, Inc.
state: Kansas
city: Kansas City
country: United States
facility: University of Kansas Medical Center
state: Kansas
city: Bowling Green
country: United States
facility: Graves-Gilbert Clinic
state: Kentucky
city: Baton Rouge
country: United States
facility: Medical Development Centers, LLC
state: Louisiana
city: Baton Rouge
country: United States
facility: Gastroenterology Associates, LLC
state: Louisiana
city: Baltimore
country: United States
facility: Mercy Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Digestive Disease Associates, PA
state: Maryland
city: Baltimore
country: United States
facility: Johns Hopkins University
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center
state: Massachusetts
city: Boston
country: United States
facility: Community Research Initiative of New England
state: Massachusetts
city: Burlington
country: United States
facility: Lahey Clinic Medical Center
state: Massachusetts
city: Springfield
country: United States
facility: The Research Institute
state: Massachusetts
city: Worcester
country: United States
facility: Partners in Internal Medicine, PC
state: Massachusetts
city: Detroit
country: United States
facility: Henry Ford Health System
state: Michigan
city: Plymouth
country: United States
facility: Minnesota Gastroenterology, P.A.
state: Minnesota
city: Rochester
country: United States
facility: 200 1st st SW
state: Minnesota
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
city: Saint Paul
country: United States
facility: Minnesota Gastroenterology, P.A.
state: Minnesota
city: Tupelo
country: United States
facility: Digestive Health Specialists
state: Mississippi
city: Kansas City
country: United States
facility: Kansas City Gastroenterology and Hepatology
state: Missouri
city: Saint Louis
country: United States
facility: Saint Louis University
state: Missouri
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
city: Las Vegas
country: United States
facility: Impact Clinical Trials
state: Nevada
city: Hillsborough
country: United States
facility: ID Care, Inc.
state: New Jersey
city: Morristown
country: United States
facility: Research Center at Affiliates in Gastroenterology
state: New Jersey
city: Newark
country: United States
facility: Saint Michael's Medical Center
state: New Jersey
city: Newark
country: United States
facility: Saint Michael's Medical Center
state: New Jersey
city: Vineland
country: United States
facility: The Gastroenterology Group of South Jersey
state: New Jersey
city: Albuquerque
country: United States
facility: University of New Mexico
state: New Mexico
city: Santa Fe
country: United States
facility: Southwest C.A.R.E. Center
state: New Mexico
city: Johnson City
country: United States
facility: Binghamton Gastroenterology Associates
state: New York
city: Manhasset
country: United States
facility: North Shore University Hospital
state: New York
city: New York
country: United States
facility: Concorde Medical Group PLLC
state: New York
city: New York
country: United States
facility: Weill Medical College of Cornell Univeristy
state: New York
city: New York
country: United States
facility: St. Luke's Roosevelt Hospital
state: New York
city: New York
country: United States
facility: Mount Sinai School of Medicine
state: New York
city: New York
country: United States
facility: Columbia University Medical Center
state: New York
city: New York
country: United States
facility: Mount Sinai Beth Israel
state: New York
city: New York
country: United States
facility: Saint Luke's-Roosevelt Hospital Center
state: New York
city: Rochester
country: United States
facility: University of Rochester
state: New York
city: Yonkers
country: United States
facility: Westchester Medical Center
state: New York
city: Asheville
country: United States
facility: Asheville Gastroenterology Associates, P.A.
state: North Carolina
city: Chapel Hill
country: United States
facility: University of North Carolina at Chapel Hill
state: North Carolina
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
city: Fayetteville
country: United States
facility: Cumberland Research Associates, LLC
state: North Carolina
city: Winston-Salem
country: United States
facility: Digestive Health Specialists, PA
state: North Carolina
city: Tulsa
country: United States
facility: Options Health Research LLC
state: Oklahoma
city: Medford
country: United States
facility: Schleinitz Research and Gastroenterology LLC
state: Oregon
city: Portland
country: United States
facility: Oregon Health & Science University
state: Oregon
city: Allentown
country: United States
facility: Lehigh Valley Health Network, Network Office of Research and Innovation
state: Pennsylvania
city: Allentown
country: United States
facility: Lehigh Valley Health Network
state: Pennsylvania
city: Lancaster
country: United States
facility: Regional Gastroenterology Associates of Lancaster, Ltd.
state: Pennsylvania
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
city: Philadelphia
country: United States
facility: Philadelphia FIGHT
state: Pennsylvania
city: Philadelphia
country: United States
facility: Philadelphia FIGHT
state: Pennsylvania
city: Philadelphia
country: United States
facility: University of Pennsylvania School of Medicine
state: Pennsylvania
city: Pittsburgh
country: United States
facility: UPMC Center For Liver Diseases
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Veterans Affairs Pittsburgh Healthcare System
state: Pennsylvania
city: Providence
country: United States
facility: The Miriam Hospital
state: Rhode Island
city: Providence
country: United States
facility: University Gastroenterology
state: Rhode Island
city: Germantown
country: United States
facility: Gastroenterology Center of the MidSouth, P.C.
state: Tennessee
city: Germantown
country: United States
facility: Memphis Gastroenterology Group
state: Tennessee
city: Germantown
country: United States
facility: Gastro One
state: Tennessee
city: Nashville
country: United States
facility: Nashville Medical Research Institute
state: Tennessee
city: Nashville
country: United States
facility: Nashville Gastrointestinal Specialists, Inc
state: Tennessee
city: Nashville
country: United States
facility: Quality Medical Research, PLLC
state: Tennessee
city: Arlington
country: United States
facility: The North Texas Research Institute
state: Texas
city: Arlington
country: United States
facility: Texas Clinical Research Institute, LLC
state: Texas
city: Austin
country: United States
facility: Austin Hospital
state: Texas
city: Austin
country: United States
facility: Central Texas Clinical Research, LLC
state: Texas
city: Dallas
country: United States
facility: Nicholaos C. Bellos
state: Texas
city: Dallas
country: United States
facility: Baylor University Medical Center
state: Texas
city: Dallas
country: United States
facility: UT Southwestern Medical Center at Dallas
state: Texas
city: Dallas
country: United States
facility: Methodist Transplant Physicians
state: Texas
city: Houston
country: United States
facility: Therapeutic Concepts, PA
state: Texas
city: Houston
country: United States
facility: Kelsey Research Foundation
state: Texas
city: Houston
country: United States
facility: Research Specialists of Texas
state: Texas
city: Houston
country: United States
facility: St. Luke's Episcopal Hospital
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine
state: Texas
city: Houston
country: United States
facility: St. Luke's Health Baylor College of Medicine Medical Center
state: Texas
city: San Antonio
country: United States
facility: Alamo Medical Research
state: Texas
city: San Antonio
country: United States
facility: The Texas Liver Institute
state: Texas
city: Salt Lake City
country: United States
facility: Lifetree Clinical Research
state: Utah
city: Salt Lake City
country: United States
facility: University of Utah Pediatric Pulmonology
state: Utah
city: Salt Lake City
country: United States
facility: PRA Health Sciences
state: Utah
city: Fairfax
country: United States
facility: Metropolitan Research
state: Virginia
city: Falls Church
country: United States
facility: Inova Fairfax Hospital Center for Liver Diseases
state: Virginia
city: Newport News
country: United States
facility: Liver Institute of Virginia
state: Virginia
city: Norfolk
country: United States
facility: Digestive and Liver Disease Specialists
state: Virginia
city: Richmond
country: United States
facility: Liver Institute of Virginia, Bon Secours Health System
state: Virginia
city: Richmond
country: United States
facility: Virginia Commonwealth University Medical Center
state: Virginia
city: Seattle
country: United States
facility: Harborview Medical Center
state: Washington
city: Madison
country: United States
facility: Wisconsin Hospital and Clinic
state: Wisconsin
city: Canberra
country: Australia
facility: Canberra Specialist Centre
state: Australian Capital Territory
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital
state: New South Wales
city: Darlinghurst
country: Australia
facility: 102 Burton Street
state: New South Wales
city: Darlinghurst
country: Australia
facility: East Sydney Doctors
state: New South Wales
city: Darlinghurst
country: Australia
facility: St Vincent's Public Hospital Sydney
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital
state: New South Wales
city: Westmead
country: Australia
facility: Westmead Hospital
state: New South Wales
city: Woolloongabba
country: Australia
facility: Greenslopes Private Hospital
state: Queensland
city: Bedford Park
country: Australia
facility: Flinders Medical Centre
state: South Australia
city: Footscray
country: Australia
facility: Footscray Hospital
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Health
state: Victoria
city: Melbourne
country: Australia
facility: Alfred Hospital - Infectious Disease Unit
state: Victoria
city: Melbourne
country: Australia
facility: Alfred Hospital
state: Victoria
city: Melbourne
country: Australia
facility: Monash Medical Centre
state: Victoria
city: Murdoch
country: Australia
facility: Fiona Stanley Hospital
state: Western Australia
city: Perth
country: Australia
facility: Royal Perth Hospital
state: Western Australia
city: Fitzroy
country: Australia
facility: St Vincent's University Hospital
city: QLD
country: Australia
facility: Royal Brisbane & Women's Hospital
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital
city: Graz
country: Austria
facility: Medizinische Universität Graz
state: Styria
city: Wien
country: Austria
facility: Wilhelminenspital der Stadt Wien
state: Vienna
city: Vancouver
country: Canada
facility: Vancouver Infectious Disease Research and Care Centre
state: British Columbia
city: Toronto
country: Canada
facility: Inspiration Research Limited
state: Ontario
city: Calgary
country: Canada
facility: University of Calgary
city: Edmonton
country: Canada
facility: University of Alberta
city: Montreal
country: Canada
facility: Hopital Saint-Luc du CHUM
city: Toronto
country: Canada
facility: Toronto General Hospital
city: Toronto
country: Canada
facility: Toronto Western Hospital
city: Vancouver
country: Canada
facility: LAIR Centre
city: Vancouver
country: Canada
facility: Gordon & Leslie Diamond Health Care Centre
city: Vancouver
country: Canada
facility: University of British Colombia
city: Vancouver
country: Canada
facility: GIRI GI Research Institute
city: Winnipeg
country: Canada
facility: University of Manitoba, Health Sciences Center
city: Praha 4
country: Czechia
facility: Remedis, s.r.o., Nestátní zdravotnické zarízení, Vladimírova 10
city: Praha 6
country: Czechia
facility: Klinmed, s.r.o.
city: Talinn
country: Estonia
facility: West Tallinn Central Hospital
city: Tartu
country: Estonia
facility: Tartu University Hospital
city: Pessac Cedex
country: France
facility: Hôpital Haut-Lévêque, CHU Bordeaux
state: Aquitaine
city: Clermont-Ferrand
country: France
facility: Centre Hospitalier Universitaire de Clermont-Ferrand
state: Auvergne
city: CRETEIL Cedex
country: France
facility: Hôpital Henri Mondor
state: Ile-de-france
city: Paris Cedex 12
country: France
facility: Service Maladies Infectieuses
state: Ile-de-france
city: Paris cedex 12
country: France
facility: Hôpital Saint-Antoine
state: Ile-de-france
city: Paris cedex 18
country: France
facility: Hôpital Bichat-Claude Bernard
state: Ile-de-france
city: Paris
country: France
facility: Hôpital La Pitié Salpétrière, Service des Maladies Infectieuses
state: Ile-de-france
city: Lille
country: France
facility: Service des Maladies de l'Appareil Digestif et de la nutrition
state: NORD Pas-de-calais
city: Lille
country: France
facility: Hôpital Claude Huriez- Service d'Hépato-Gastroentérologie
state: NORD Pas-de-calais
city: Marseille cedex 08
country: France
facility: Hôpital-Saint Joseph, Service D'Hépato-Gastroentérologie
state: Provence Alpes COTE D'azur
city: Nice
country: France
facility: Hôpital de I´Archet 2
state: Provence Alpes COTE D'azur
city: Cedex 9
country: France
facility: Centre Hospitalier Universitaire de Grenoble
state: Rhone-alpes
city: clichy Cedex
country: France
facility: Hopital Beaujon
city: Montpellier
country: France
facility: Hopital Saint-Eloi
city: Nice cedex 3
country: France
facility: CHU de Nice - Hôpital l'Archet
city: Paris
country: France
facility: Hôpital Saint Louis, Services des Maladies Infectieuses
city: Paris
country: France
facility: Hopital Pitie-Salpetriere
city: Rennes Cedex 9
country: France
facility: Hopital Pontchaillou
city: Strasbourg
country: France
facility: C.H.U. Strasbourg - Hôpital Hautpierre - Hématologie
city: Vandoeuvre
country: France
facility: CHU de Nancy
city: Freiburg im Breisgau
country: Germany
facility: Bertoldstrasse 48
state: Baden-wuerttemberg
city: Freiburg
country: Germany
facility: Albert-Ludwigs-Universität
state: Baden-wuerttemberg
city: Heidelberg
country: Germany
facility: Medizinische Universitätsklinik IV (Krehl Klinik) Abt. Gastroenterologie und Infektionskrankhen
state: Baden-wuerttemberg
city: Frankfurt am Main
country: Germany
facility: Infektiologikum
state: Hessen
city: Frankfurt am Main
country: Germany
facility: Universitätsklinikum Frankfurt
state: Hessen
city: Hannover
country: Germany
facility: CRC Hannover
state: Niedersachsen
city: Düsseldorf
country: Germany
facility: Medizinisches Versorgungszentrum
state: Nordrhein-westfalen
city: Düsseldorf
country: Germany
facility: Universitätsklinikum Düsseldorf
state: Nordrhein-westfalen
city: Essen
country: Germany
facility: Medizinisches Zentrum - Klinik für Gastroenterologie und Hepatologie
state: Nordrhein-westfalen
city: Herne
country: Germany
facility: Gastroenterologische Gemeinschaftspraxis
state: Nordrhein-westfalen
city: Köln
country: Germany
facility: Klinik für Gastroenterologie und Hepatologie am Abdominalzentrum
state: Nordrhein-westfalen
city: Berlin
country: Germany
facility: Leber- and Studienzentrum am Checkpoint
city: Berlin
country: Germany
facility: Charite Campus Virchow-Klinikum
city: Berlin
country: Germany
facility: Seestrasse 13
city: Berlin
country: Germany
facility: MIB Dienstleistung GmbH
city: Bonn
country: Germany
facility: Universitätsklinikum Bonn
city: Dusseldorf
country: Germany
facility: Center for HIV and Hepatogastroenterology
city: Frankfurt
country: Germany
facility: Klinikum der Johann Wolfgang Goethe Universitaet
city: Frankfurt
country: Germany
facility: Klinikum der Johann Wolfgang-Goethe-Universität
city: Frankfurt
country: Germany
facility: Universitätsklinikum Frankfurt
city: Freiburg
country: Germany
facility: Medizinische Universitatsklinik
city: Hamburg
country: Germany
facility: Asklepios Klinik St. Georg
city: Hamburg
country: Germany
facility: Universitatsklinikum Hamburg-Eppendorf
city: Hamburg
country: Germany
facility: Institut für interdisziplinäre Medizin Studien GmbH an der Asklepiosklinik Saint Georg
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
city: Heidelberg
country: Germany
facility: Klinikum der Universität Heidelberg
city: Kiel
country: Germany
facility: Gastroenterologische Gemeinschaftspraxis Kiel
city: Leipzig
country: Germany
facility: University of Leipzig
city: Mainz
country: Germany
facility: Johannes Gutenberg University Hospital
city: Mainz
country: Germany
facility: Mainz University
city: Muenchen
country: Germany
facility: Klinikum Innenstadt der LMU Munchen
city: Wurzburg
country: Germany
facility: Universitätsklinikum Würzburg - Med Klinik und Poliklinik
city: Wüerzburg
country: Germany
facility: Universitätsklinik Würzburg
city: San Giovanni Rotondo
country: Italy
facility: Casa Sollievo della Sofferenza Hospital
state: Foggia
city: Bergamo
country: Italy
facility: Azienda Ospedaliera Papa Giovanni XXIII
city: Bologna
country: Italy
facility: Azienda Ospedaliera di Bologna - Policlinico S. Orsola Malpighi
city: Bologna
country: Italy
facility: Azienda Ospedaliera S. Orsola - Malpighi
city: Genova
country: Italy
facility: Ente Ospedaliero Ospedali Galliera di Genova
city: Milano
country: Italy
facility: Ospedale San Raffaele-IRCCS, Centro San Luigi - San Raffaele Turro, Unità Operativa di Malattie Infettive
city: Milano
country: Italy
facility: Azienda Ospedaliera
city: Milano
country: Italy
facility: Dipartimento Polispecialistico - Malattie Infetive
city: Milano
country: Italy
facility: Azienda Ospedaliera Ospedale Niguarda Ca' Granda
city: Milano
country: Italy
facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
city: Padova
country: Italy
facility: Azienda Ospedaliera Padova, U.O.C. Cardiologia
city: Palermo
country: Italy
facility: Azienda Ospedaliera-universitaria Policlinico P. Giaccone
city: Parma
country: Italy
facility: Azienda Ospedaliero Universitaria di Parma
city: Roma
country: Italy
facility: Malattie Infettive - Epatologia
city: Roma
country: Italy
facility: Fondazione Policlinico Tor Vergata
city: Torino
country: Italy
facility: Azienda Ospedaliera Città della Salute e della Scienza di Torino
city: Amsterdam
country: Netherlands
facility: Academisch Medisch Centrum
state: Noord-holland
city: Leiden
country: Netherlands
facility: Leiden Universitair Medisch Centrum
state: Zuid-holland
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum
state: Zuid-holland
city: Nijmegen
country: Netherlands
facility: Universitair Medisch Centrum Sint Radboud
city: Grafton
country: New Zealand
facility: Auckland Clinical Studies Limited
state: Auckland
city: Grafton
country: New Zealand
facility: Middlemore Hospital
state: Auckland
city: Grafton
country: New Zealand
facility: Auckland City Hospital
state: Auckland
city: Tauranga
country: New Zealand
facility: Bay of Plenty Clinical School
state: BAY OF Plenty
city: Newton
country: New Zealand
facility: Wellington Hospital
state: WGN
city: Christchurch
country: New Zealand
facility: Christchurch Hospital
city: Hamilton
country: New Zealand
facility: Waikato Hospital (District Health Board)
city: Hamilton
country: New Zealand
facility: Urosurgery
city: Wellington
country: New Zealand
facility: Wellington Hospital
city: Wroclaw
country: Poland
facility: Centrum Badan Klinicznych Osrodek Badan Wczesnej Fazy
state: Dolnoslaskie
city: Wroclaw
country: Poland
facility: NZOZ Centrum Badan Klinicznych
state: Dolnoslaskie
city: Warszawa
country: Poland
facility: Oddzial Dzienny
state: Mazowieckie
city: Warszawa
country: Poland
facility: SP ZOZ Wojewódzki Szpital Zakazny
state: Mazowieckie
city: Bialystok
country: Poland
facility: Wojewódzki Szpital Specjalistyczny im. Kazimierza Dluskiego w Bialymstoku
state: Podlaskie
city: Chorzów
country: Poland
facility: Szpital Specjalistyczny w Chorzowie
state: Slaskie
city: Myslowice
country: Poland
facility: ID Clinic
state: Slaskie
city: Chorzow
country: Poland
facility: SP ZOZ Wojewodzki Szpital Zakazny w Warszawie
city: Lodz
country: Poland
facility: Wojewodzki Specjalistyczny Szpital im. W. Bieganskiego
city: Myslowice
country: Poland
facility: NZOZ Pol-SaNa-Med
city: San Juan
country: Puerto Rico
facility: Chattanooga Hem/Oncology Ass (SCRI)
city: San Juan
country: Puerto Rico
facility: Fundacion De Investigacion De Diego
city: San Juan
country: Puerto Rico
facility: Clinical Research Puerto Rico
city: Majadahonda
country: Spain
facility: C / Manuel de Falla
state: Madrid
city: Majadahonda
country: Spain
facility: Hospital Puerta de Hierro Majadahonda
state: Madrid
city: Barcelona
country: Spain
facility: Hospital Clinic I Provincial de Barcelona
city: Barcelona
country: Spain
facility: Hospital Clinic I Provincial de Barcelona
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañon
city: Madrid
country: Spain
facility: Hospital Moncloa, Servicio de Enfermedades Infecciosas
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Madrid
country: Spain
facility: Paseo de la Castellana nº 261
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Sevilla
country: Spain
facility: Hospital Universitario Nuestra Señora de Valme
city: Sevilla
country: Spain
facility: Hospital Universitario Nuestra Señora de Valme
city: Valencia
country: Spain
facility: Avenida Tres Cruces s/n
city: Valencia
country: Spain
facility: Hospital General Universitario de Valencia
city: Göteborg
country: Sweden
facility: Sahlgrenska Universitetssjukhuset, Östra sjukhuset
state: Vastra Gotaland
city: Göteborg
country: Sweden
facility: Sahlgrenska Universitetssjukhuset, Östra Sjukhus
city: Lund
country: Sweden
facility: Skånes Universitetssjukhus
city: Lund
country: Sweden
facility: Skånes Universitetssjukhus i Lund
city: Malmö
country: Sweden
facility: Skånes Universitetssjukhus, Malmö
city: Solna
country: Sweden
facility: Karolinska Universitetssjukhuset Solna
city: Birmingham
country: United Kingdom
facility: University of Birmingham and Queen Elizabeth Hospital Birmingham
state: England
city: Hampshire
country: United Kingdom
facility: Southampton University Hospitals NHS Trust, Southampton General Hospital
state: England
city: London
country: United Kingdom
facility: Westminster Bridge Road
state: England
city: London
country: United Kingdom
facility: Chelsea and Westminster Hospital NHS Foundation Trust
state: England
city: London
country: United Kingdom
facility: Guy's and Saint Thomas NHS Foundation Trust
state: England
city: London
country: United Kingdom
facility: Imperial College Healthcare NHS Trust
state: England
city: London
country: United Kingdom
facility: King's College Hospital
state: England
city: London
country: United Kingdom
facility: St George Hospital
state: England
city: Manchester
country: United Kingdom
facility: North Manchester General Hospital
state: England
city: Nottingham
country: United Kingdom
facility: Queen's Medical Centre Campus
state: England
city: Oxford
country: United Kingdom
facility: John Radcliffe Hospital
state: England
city: Bristol
country: United Kingdom
facility: Marlborough Street
city: Plymouth
country: United Kingdom
facility: Derriford Hospital
Study officials:
affiliation: Gilead Sciences
name: Gilead Study Director
role: STUDY_DIRECTOR
References:
citation: Younossi ZM, Stepanova M, Racila A, Afendy A, Lawitz EJ, Schwabe C, Ruane PJ, Lalezari J, Reddy KR, Jacobson IM, Muir AJ, Gaggar A, Myers RP, Younossi I, Nader F. Long-term Benefits of Sustained Virologic Response for Patient-Reported Outcomes in Patients With Chronic Hepatitis C Virus Infection. Clin Gastroenterol Hepatol. 2020 Feb;18(2):468-476.e11. doi: 10.1016/j.cgh.2019.07.047. Epub 2019 Jul 31.
citation: Younossi ZM, Stepanova M, Jacobson I, Muir AJ, Pol S, Zeuzem S, Younes Z, Herring R, Lawitz E, Younossi I, Racila A. Not Achieving Sustained Viral Eradication of Hepatitis C Virus After Treatment Leads to Worsening Patient-reported Outcomes. Clin Infect Dis. 2020 Feb 3;70(4):628-632. doi: 10.1093/cid/ciz243.