louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00316979: Efficacy of rTMS in the Treatment of Patients With Migraine
Official title: Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Migraine Using Somatosensory Evoked High-Frequency Oscillations as a Parameter: A 3-year Study.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Migraine
Keywords: migraine
transcranial magnetic stimulation
repetitive transcranial magnetic stimulation
rTMS
Lead sponsor: Taipei Veterans General Hospital, Taiwan
Sponsor class: OTHER_GOV
Collaborators: name: National Science and Technology Council, Taiwan
First posted: 2006-04-21
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Migraine is a condition thought to be related to cortical hyperexcitability. Repetitive transcranial magnetic stimulation (rTMS) can modulate the cortical excitability by means of long-term potentiation or long-term depression. This study will will test the safety and efficacy of rTMS in the treatment of patients with Migraine.


Eligibility criteria: Inclusion Criteria:

* Age of 18-65 years
* Diagnosed as migraine (with or without aura)
* More than 4 attacks per month for at least 3 months prior to study
* No preventive medication used
* Must be able to sign permit

Exclusion Criteria:

* History of seizure or family history of seizures
* Women in pregnancy or breast-feeding
* Patient with medication overuse
* Patient with other medical, psychologic, or surgical illness
* Patient under preventive medications
* Prior rTMS examination one month within

Primary outcomes:
measure: Reduction in days of migraine attack per month
Secondary outcomes:
measure: The reduction in dosage of acute abortive medication
measure: The reduction of headache index
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Headache Center, Teipei Veterans General Hospital
Study officials:
affiliation: Headache Center, Taipei Veterans General Hospital
name: Shuu-Jiun Wang, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Brighina F, Piazza A, Vitello G, Aloisio A, Palermo A, Daniele O, Fierro B. rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study. J Neurol Sci. 2004 Dec 15;227(1):67-71. doi: 10.1016/j.jns.2004.08.008.
citation: Lorenz J, Minoshima S, Casey KL. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain. 2003 May;126(Pt 5):1079-91. doi: 10.1093/brain/awg102.
Clinical trial NCT03127579: Family Meal Duration and Children's Eating Behavior
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Feeding Behavior
Eating
Child Behavior
Family Relations
Lead sponsor: Max Planck Institute for Human Development
Sponsor class: OTHER
Collaborators: name: University of Mannheim
First posted: 2017-04-25
Enrollment: 50
Sex: ALL
Minimum age (years): 6
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The goal of this study is to test whether a longer meal duration could improve the diet quality of children. To answer this question we want to take an experimental approach by implementing a longer family meal duration to examine differences in children's eating behavior. The family dinner within a laboratory setting will be video taped and the main outcome is children's fruit and vegetables consumption.

Detailed description: Parent-child pairs have two dinner in a laboratory setting. The study design is a within-subject design: In the control condition they have as much time as they usual. In the intervention condition they have 50% more time than usual. Order of the two condition is counter balanced. The lab dinner reflects a typical German dinner which consists of bread, cheese, cold meat and fruits and vegetables. Additionally a dessert is served after the main meal. The foods served reflect food preferences of the child. All dinners are video taped. Key outcome variables are consumption of fruits and vegetables, dessert, eating rate and amount time engaged in positive and negative social interaction

Eligibility criteria: Inclusion Criteria:

* children and their nutritional gatekeeper

Exclusion Criteria:

* food allergies
* participants follow special diet

Primary outcomes:
measure: Food consumption
timeFrame: Food intake is measured during the lab meal
Secondary outcomes:
measure: Social interactions: positive and negative communication
timeFrame: Social interaction is measured during the lab meal
measure: Eating rate
timeFrame: From the start to the end of the meal (about 20-30 minutes)
measure: Hunger
timeFrame: Participants filled out a questionnaire 5 minutes after the lab dinner
measure: Atmosphere
timeFrame: Participants filled out a questionnaire 5 minutes after the lab dinner
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Max Planck Institute for Human Development
Study officials:
References:
Clinical trial NCT03843879: TAP Blocks vs. IV Lidocaine for Kidney Transplants
Official title: A Comparison of Transversus Abdominis Plane Blocks Versus Continuous Intravenous Lidocaine for Kidney Transplant Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
PHASE3
Conditions: Postoperative Pain
Lead sponsor: Benaroya Research Institute
Sponsor class: OTHER
First posted: 2019-02-18
Enrollment: 124
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will compare continuous intravenous lidocaine against single-injection transversus abdominis plane (TAP) block as a modality for postoperative analgesia in kidney transplant surgery.

Detailed description: This study is a non-inferiority trial designed to assess the analgesic efficacy of an intravenous (IV) lidocaine infusion against single-injection transversus abdominis plane (TAP) block in patients undergoing kidney transplant surgery. The investigators propose a study of 124 subjects randomized into two groups. The control group will receive a TAP block. The study group will receive a continuous IV lidocaine infusion. The investigators hypothesize that there will be no statistically significant difference in postoperative opioid consumption between the two groups in the first 24 hours.

Eligibility criteria: Inclusion Criteria:

* Kidney transplant recipient
* \>18 years old
* Consent to participate

Exclusion Criteria:

* \<18 years old
* Refusal to participate
* Chronic opioid use
* Seizure disorder
* Allergy to local anesthestics
* Severe hepatic disease

Primary outcomes:
measure: Opioid Consumption
timeFrame: 0-24 Hours
Secondary outcomes:
measure: Pain Scores
timeFrame: 0-48 Hours
measure: Opioid Consumption
timeFrame: 24-48 Hours
measure: Opioid-Related Adverse Events
timeFrame: 0-48 Hours
measure: Block/Infusion-Related Adverse Events
timeFrame: 0-48 Hours
measure: Opioid Usage
timeFrame: 30 days from discharge
Other outcomes:
Locations:
city: Seattle
country: United States
facility: Virginia Mason Medical Center
state: Washington
Study officials:
affiliation: Virginia Mason Medical Center
name: Neil A Hanson, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hanson NA, Strunk J, Saunders G, Cowan NG, Brandenberger J, Kuhr CS, Oryhan C, Warren DT, Slee AE, Strodtbeck W. Comparison of continuous intravenous lidocaine versus transversus abdominis plane block for kidney transplant surgery: a randomized, non-inferiority trial. Reg Anesth Pain Med. 2021 Nov;46(11):955-959. doi: 10.1136/rapm-2021-102973. Epub 2021 Aug 20.
Clinical trial NCT06624579: Prognostic Value of Confocal Endomicroscopy in Ulcerative Colitis: the CONF-UC Study
Official title: Prognostic Value of Confocal Endomicroscopy in Ulcerative Colitis: the CONF-UC Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Ulcerative Colitis
Lead sponsor: IRCCS Ospedale San Raffaele
Sponsor class: OTHER
First posted: 2024-10-03
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: 26 adult subjects with moderate-to-severe active (defined as having patient-reported outcomes, PRO \&gt; 2), left-sided or extensive UC, requiring small molecules therapy according to the standards of care (ECCO guidelines) and performing routine investigations with Colonoscopy before starting appropriate therapy, according to the current standard of care indications and ECCO guidelines.
Primary purpose: OTHER

Brief summary: This study employs a prospective, single-center, interventional design to investigate the prognostic value of confocal endomicroscopy in assessing treatment response in ulcerative colitis (UC) patients receiving small molecules .

Detailed description: The study incorporates confocal endomicroscopy as an additional diagnostic modality for assessing barrier dysfunction and treatment response in UC patients. Confocal endomicroscopy enables real-time visualization of mucosal changes at a cellular level during endoscopy, potentially enhancing the detection of treatment response and mucosal healing.

Eligible patients will undergo baseline assessment, including clinical evaluation, partial Mayo score calculation, endoscopic evaluation, biopsies with histological evaluation and confocal endomicroscopy. Follow-up assessments will be conducted at 8 weeks and 6 months after initiating therapy with small molecules .

The study aims to enroll a sample size of 26 UC patients to pilot the feasibility and utility of confocal endomicroscopy in assessing barrier dysfunction and treatment response.

Eligibility criteria: Inclusion Criteria:

1. Established diagnosis of UC since at least 12 weeks prior to inclusion
2. Age ≥ 18 years
3. Any gender/sex
4. Active disease consistent with indication to start with Small molecules (defined as Mayo endoscopic score (MES) ≥ 1, partial Mayo score ≥ 3 (with at least rectal bleeding score of 1 and bowel movements score of 1)
5. No contraindications to endoscopy or confocal exam
6. Ability to understand and to comply with the study procedure and sign an informed consent form

Exclusion Criteria:

1. Subjects with an endoscopic Mayo sub-score at baseline \&lt;2;
2. Pregnancy
3. Subjects with any contraindication to any study procedure (included fluorescein allergy).

Primary outcomes:
measure: Prognostic Value of Confocal Endomicroscopy in Ulcerative Colitis
timeFrame: at 8 weeks and 6 months to treatment initiation
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02333279: Cancer Development In Organ Transplant Recipients
Official title: Cancer Development In Organ Transplant Recipients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart Cancer
Kidney Cancer
Lung Cancer
Pancreas Cancer
Liver Cancer
Lead sponsor: University of Zurich
Sponsor class: OTHER
Collaborators: name: University Hospital, Basel, Switzerland
name: Insel Gruppe AG, University Hospital Bern
name: Cantonal Hospital of St. Gallen
name: University Hospital, Geneva
name: University of Lausanne Hospitals
First posted: 2015-01-07
Enrollment: 1800
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All solid organ transplant recipients in Switzerland since 2008 who have given their consent to be included in the study.

Brief summary: The investigators will determine the cancer risk in organ transplant recipients compared to the general population with the help of statistical analysis. Secondly the investigators will try to characterize the different cancer types.

Detailed description: This cohort analyses will focus on incident and recurrent cases of development of non-skin cancer over time. We will consider time to first formation of non-skin solid cancer after solid organ transplantation as well as the cumulative number of non-skin solid cancer formation over time. Both aspects are equally important and will be reflected in the analytic methods of this study. Theses analyses will be restricted to the most prevalent transplantation types of heart, kidney, liver, and lung.

Eligibility criteria: Inclusion Criteria:

We will select all patients within the STCS based on the date of the first solid organ transplantation. Patients with multiple organ transplantations will be included as well. Patients contribute to the study observation time until death or end of follow-up due to other reasons.

Exclusion Criteria:

We will exclude patients with non-solid organ transplantation (e.g. hematopoietic stem cell transplantation), because the detailing of information in the STCS is insufficient to allow for detailed analysis of cancer development and control of relevant confounders. We will exclude

Primary outcomes:
measure: Number of solid cancers
timeFrame: Ten Year followup
Secondary outcomes:
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: University Hospital Zurich, Division of Dermatology
Study officials:
affiliation: University Hospital, Zürich
name: Gunther FL Hofbauer, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lengwiler E, Stampf S, Zippelius A, Salati E, Zaman K, Schafer N, Schardt J, Siano M, Hofbauer G, The Swiss Transplant Cohort Study. Solid cancer development in solid organ transplant recipients within the Swiss Transplant Cohort Study. Swiss Med Wkly. 2019 May 19;149:w20078. doi: 10.4414/smw.2019.20078. eCollection 2019 May 6.
Clinical trial NCT05769179: Comparison of Different Manual Therapy Approaches in Patients With Chronic Neck Pain
Official title: Comparison of Different Manual Therapy Approaches in Patients With Chronic Neck Pain
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Neck Pain
Lead sponsor: Ankara Yildirim Beyazıt University
Sponsor class: OTHER
First posted: 2023-03-15
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study was to compare the effects of different manual therapy approaches on pain, cervical range of motion, balance, functional status and life quality in patients with chronic neck pain.

Detailed description: Various physiotherapy and rehabilitation methods are applied in the treatment of patients with chronic neck pain. Clinical practice guidelines for individuals with chronic neck pain recommend both manual therapy and exercise therapy among conservative treatments. Manual therapy are methods that can be safely applied to soft tissues and joints. Both manual therapy and exercise applications have been shown to have positive effects on neck pain and function. Some studies in the literature have also shown that manual therapy methods have positive effects on balance. However, no study examining the effects of different manual therapy (classical massage, connective tissue massage, manual joint techniques) approaches applied to individuals with chronic neck pain on pain, cervical range of motion, balance, functional status and quality of life was found in the literature.

Eligibility criteria: Inclusion Criteria:

* To be between the ages of 18-65.
* To participate in the study voluntarily.
* Having a complaint of neck pain for at least 3 months.

Exclusion Criteria:

* To have undergone cervical spine surgery
* Having cervical fracture and/or joint subluxation/dislocation
* Severe degenerative arthritis
* Having a neurological disease (Parkinson's disease, poliomyelitis, etc.) or an -inflammatory rheumatic disease (ankylosing spondylitis, rheumatoid arthritis, etc.)
* Presence of malignancy
* Having cord compression and signs
* Severe radiculopathy or myelopathy
* Positive vertebrobasilar artery test,
* Pregnancy

Primary outcomes:
measure: Pain Intensity
timeFrame: change from baseline at 4 weeks
Secondary outcomes:
measure: Pressure Pain Threshold
timeFrame: change from baseline at 4 weeks
measure: Cervical Range of Motion
timeFrame: change from baseline at 4 weeks
measure: Balance
timeFrame: change from baseline at 4 weeks
measure: Functional Status
timeFrame: change from baseline at 4 weeks
measure: Life quality
timeFrame: change from baseline at 4 weeks
Other outcomes:
Locations:
Study officials:
affiliation: Ankara Yildirim Beyazıt University
name: Seyda Toprak Celenay
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04648579: Automated Documentation of Vital Parameters Using Mobile Stations and Activation of the Rapid Response Team
Official title: Automated Documentation of Vital Parameters in Wards Using Mobile Stations - Effect on the Appropriate Activation of the Rapid Response Team: a Cluster Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Inpatient Facililty Diagnoses
Lead sponsor: Hospital do Coracao
Sponsor class: OTHER
First posted: 2020-12-01
Enrollment: 231
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The documentation of vital signs is traditionally performed manually when the patient is not admitted in intensive care units, which can lead to documentary errors, long time for data acquisition and, consequently, impairment in the early identification of possible clinical deterioration. In-bed technology solutions are available to automate the collection of vital data and transfer information to a medical record or central electronic monitoring and its role in the health value chain needs further investigation. The investigators propose to evaluate the impact of the Connex Spot Monitor solution Welch Allyn (CSM / Hillrom) in conjunction with the Hillrom Connecta solution in a real world situation, conducting a cluster randomized trilal in wards of a tertiary hospital. In addition, this study aims to estimate the clinical effectiveness of a technological solution that performs an analysis of vital signs and automatically activates the rapid response team (RRT) when the pre-defined criteria are met, comparing it with the traditional manual method. The primary outcome is the number of times that the RRT fires in a timely manner.


Eligibility criteria: Inclusion Criteria:

- All patients with activated RRT during the study recruitment period.

Exclusion Criteria:

- Individuals who need blood pressure measurement in lower members.

Primary outcomes:
measure: RRT
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Hospital do Coracao
state: Sao Paulo
Study officials:
affiliation: Hospital do Coracao
name: José César Ribeiro, RN
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ribeiro JC, Sgorbissa C, Silva KA, Braz MLD, Horak ACP, Nicola ML, Gurgel RM, Tokunaga SM, Negrelli KL, Murizine GS, Medrado Junior F, Coli RCP, Cavalcanti AB, Marcadenti A. Automated documentation of vital parameters in wards using portable stations - Effect on proper triggering of the rapid response team: a study protocol of a cluster randomized clinical trial. Rev Bras Ter Intensiva. 2022 Nov 4;34(3):319-326. doi: 10.5935/0103-507X.20220101-pt. eCollection 2022.
Clinical trial NCT03990779: Echocardiography Findings and Perioperative Outcomes in Children
Official title: Echocardiography Findings and Perioperative Outcomes in Children Undergoing Congenital Heart Surgery: Prospective Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Congenital Cardiac Defect
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2019-06-19
Enrollment: 400
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Pediatric patients undergoing cardiac surgery

Brief summary: This study evaluates the association between perioperative echocardiographic Doppler findings and clinical outcomes in pediatric patients undergoing cardiac surgery. In our center, anesthesiologists perform transthoracic or transesophageal echocardiography during perioperative period routinely in children undergoing surgery for congenital cardiac disease. Echocardiographic findings include the doppler patterns of hepatic vein, portal vein, renal artery, renal vein and splenic vein before and after cardiopulmonary bypass. Portal pulsatility index, renal resistive index, and respiratory variations in peak aortic blood flow velocity and diameter of inferior vena cava are measured.


Eligibility criteria: Inclusion Criteria:

* All pediatric patients undergoing cardiac surgery

Exclusion Criteria:

* Applying extracorporeal membrane oxygenator prior to surgery
* Trouble applying echocardiography

Primary outcomes:
measure: Characteristics of Doppler values and its derived parameters of portal vein, hepatic vein, renal artery and vein, and splenic vein measured using echocardiography in children with congenital cardiac disease
timeFrame: after anesthetic induction until the end of surgery
measure: Association between Doppler values measured by echocardiography and clinical outcomes after pediatric cardiac surgery
timeFrame: through study completion, an average 1-2 years
Secondary outcomes:
measure: Number of patients with major adverse outcomes after pediatric cardiac surgery
timeFrame: through study completion, an average 1-2 years
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References: