Clinical trial NCT00234884: Post-marketing Observational Study in Subjects With Rheumatoid Arthritis
Official title: A Five-year, Post-marketing Observational Study to Follow-up Patients With Rheumatoid Arthritis Formerly Treated in Study M02-497 (ReAct) and Subsequently Prescribed Humira
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rheumatoid Arthritis
Keywords: rheumatoid arthritis
adalimumab
Lead sponsor: Abbott
Sponsor class: INDUSTRY
First posted: 2005-10-10
Enrollment: 3435
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants were patients with rheumatoid arthritis (RA) who had received adalimumab for at least 3 months in NCT00448383 (Study M02-497) and had been prescribed commercial adalimumab following termination of that study. At the time of enrollment in NCT00448383 (Study M02-497), participants had failed one or more disease-modifying antirheumatic drugs (DMARDs) and had active, moderate to severe RA despite concurrent RA treatment.

Brief summary: The purpose of this observational study was to observe and assess the long term use, safety, and effectiveness of adalimumab in a normal clinical setting.

Detailed description: This was a multicenter, uncontrolled, 5-year observational study of adalimumab in the treatment of patients with rheumatoid arthritis (RA) who had received adalimumab for at least 3 months in NCT00448383 (Study M02-497), an interventional study that ended when adalimumab became commercially available for the treatment of RA. Participants had to have been receiving ongoing adalimumab treatment at the time NCT00448383 (Study M02-497) ended and been prescribed commercial adalimumab, and could have received commercial adalimumab for up to 1 year afterward prior to enrollment in NCT00234884 (Study M03-634).

Physician investigators were encouraged to treat participants as they would any other patient with RA in their routine clinical practice, and were free to determine the appropriate therapy for each patient. Concomitant treatment with disease-modifying antirheumatic drugs (DMARDs), including methotrexate, could be continued while receiving adalimumab. If treatment with adalimumab was permanently discontinued for any reason, participants were discontinued from the study and the reason was recorded. Investigators were asked to record adverse events up to 3 months after last administration of adalimumab.

Eligibility criteria: Inclusion Criteria:

* Participants with ongoing adalimumab treatment who completed at least Month 3 (Visit 5) of NCT00448383 (Study M02-497) and who had subsequently been prescribed adalimumab according to the Summary of Product Characteristics (SmPC).
* Participants must have been willing to consent to data being collected and provided to Abbott.

Exclusion Criteria:

· Participants with contraindications according to the SmPC.

Primary outcomes:
measure: Disease Activity Score in 28 Joints (DAS28) Based on Erythrocyte Sedimentation Rate (ESR)
timeFrame: Baseline, Months 12, 24, 36, 48, and 60, and Last Observed Value
measure: American College of Rheumatology 20% (ACR20) Response Rate
timeFrame: Baseline, Months 12, 24, 36, 48, and 60, and Last Observed Value
measure: American College of Rheumatology 50% (ACR50) Response Rate
timeFrame: Baseline, Months 12, 24, 36, 48, and 60, and Last Observed Value
measure: American College of Rheumatology 70% (ACR70) Response Rate
timeFrame: Baseline, Months 12, 24, 36, 48, and 60, and Last Observed Value
measure: Change From Baseline in the Health Assessment Questionnaire Disability Index (HAQ-DI)
timeFrame: Baseline, Months 12, 24, 36, 48, and 60, and Last Observed Value
Secondary outcomes:
Other outcomes:
Locations:
city: Camperdown
country: Australia
facility: Site Ref # / Investigator 5606
state: New South Wales
city: New Lambton
country: Australia
facility: Site Ref # / Investigator 49504
state: New South Wales
city: Brisbane
country: Australia
facility: Site Ref # / Investigator 49508
state: Queensland
city: Woodville
country: Australia
facility: Site Ref # / Investigator 49505
state: South Australia
city: West Heidelberg
country: Australia
facility: Site Ref # / Investigator 49503
state: Victoria
city: Cairns
country: Australia
facility: Site Ref # / Investigator 49502
city: Bad Schallerbach
country: Austria
facility: Site Ref # / Investigator 49747
city: Graz
country: Austria
facility: Site Ref # / Investigator 49517
city: Graz
country: Austria
facility: Site Ref # / Investigator 49521
city: Innsbruck
country: Austria
facility: Site Ref # / Investigator 49518
city: Klagenfurt
country: Austria
facility: Site Ref # / Investigator 49746
city: Laab im Walde
country: Austria
facility: Site Ref # / Investigator 49748
city: Linz
country: Austria
facility: Site Ref # / Investigator 49516
city: Oberpullendorf
country: Austria
facility: Site Ref # / Investigator 49523
city: St. Poelten
country: Austria
facility: Site Ref # / Investigator 49745
city: Stockerau
country: Austria
facility: Site Ref # / Investigator 49519
city: Vienna
country: Austria
facility: Site Ref # / Investigator 49520
city: Vienna
country: Austria
facility: Site Ref # / Investigator 4961
city: Aalst
country: Belgium
facility: Site Ref # / Investigator 49794
city: Antwerp
country: Belgium
facility: Site Ref # / Investigator 49817
city: Assebroek
country: Belgium
facility: Site Ref # / Investigator 49788
city: Baudour
country: Belgium
facility: Site Ref # / Investigator 49764
city: Belsele
country: Belgium
facility: Site Ref # / Investigator 49808
city: Bonheiden
country: Belgium
facility: Site Ref # / Investigator 49806
city: Bonheiden
country: Belgium
facility: Site Ref # / Investigator 49809
city: Braine-l'Alleud
country: Belgium
facility: Site Ref # / Investigator 49798
city: Bruges
country: Belgium
facility: Site Ref # / Investigator 49773
city: Brussels
country: Belgium
facility: Site Ref # / Investigator 49774
city: Brussels
country: Belgium
facility: Site Ref # / Investigator 49763
city: Brussels
country: Belgium
facility: Site Ref # / Investigator 49791
city: Brussels
country: Belgium
facility: Site Ref # / Investigator 49762
city: Brussels
country: Belgium
facility: Site Ref # / Investigator 49811
city: Brussels
country: Belgium
facility: Site Ref # / Investigator 49807
city: Brussels
country: Belgium
facility: Site Ref # / Investigator 49772
city: Chimay
country: Belgium
facility: Site Ref # / Investigator 49780
city: Destelbergen
country: Belgium
facility: Site Ref # / Investigator 49795
city: Edegem
country: Belgium
facility: Site Ref # / Investigator 49768
city: Genk
country: Belgium
facility: Site Ref # / Investigator 49776
city: Genk
country: Belgium
facility: Site Ref # / Investigator 49813
city: Ghent
country: Belgium
facility: Site Ref # / Investigator 26424
city: Gosselies
country: Belgium
facility: Site Ref # / Investigator 49766
city: Hamme
country: Belgium
facility: Site Ref # / Investigator 49781
city: Hasselt
country: Belgium
facility: Site Ref # / Investigator 49814
city: Hasselt
country: Belgium
facility: Site Ref # / Investigator 49810
city: Kortrijk
country: Belgium
facility: Site Ref # / Investigator 49777
city: La Louviere
country: Belgium
facility: Site Ref # / Investigator 49767
city: La Louviere
country: Belgium
facility: Site Ref # / Investigator 49801
city: Leuven
country: Belgium
facility: Site Ref # / Investigator 49816
city: Liege
country: Belgium
facility: Site Ref # / Investigator 49789
city: Lier
country: Belgium
facility: Site Ref # / Investigator 49775
city: Lokeren
country: Belgium
facility: Site Ref # / Investigator 49778
city: Mechelen
country: Belgium
facility: Site Ref # / Investigator 49771
city: Mechelen
country: Belgium
facility: Site Ref # / Investigator 49815
city: Merksem
country: Belgium
facility: Site Ref # / Investigator 49796
city: Mons
country: Belgium
facility: Site Ref # / Investigator 49785
city: Montignies-sur-Sambre
country: Belgium
facility: Site Ref # / Investigator 49891
city: Namur
country: Belgium
facility: Site Ref # / Investigator 49770
city: Namur
country: Belgium
facility: Site Ref # / Investigator 49783
city: Nukerke
country: Belgium
facility: Site Ref # / Investigator 49797
city: Oostende
country: Belgium
facility: Site Ref # / Investigator 49787
city: Ottignies
country: Belgium
facility: Site Ref # / Investigator 49802
city: Sijsele
country: Belgium
facility: Site Ref # / Investigator 49793
city: Sint-Niklaas
country: Belgium
facility: Site Ref # / Investigator 49805
city: Aix en Provence
country: France
facility: Site Ref # / Investigator 49615
city: Aix Les Bains
country: France
facility: Site Ref # / Investigator 49332
city: Angers
country: France
facility: Site Ref # / Investigator 49350
city: Aulnay Sous Bois
country: France
facility: Site Ref # / Investigator 49604
city: Belfort
country: France
facility: Site Ref # / Investigator 49340
city: Berck
country: France
facility: Site Ref # / Investigator 49621
city: Besancon
country: France
facility: Site Ref # / Investigator 49339
city: Bobigny
country: France
facility: Site Ref # / Investigator 49351
city: Bordeaux
country: France
facility: Site Ref # / Investigator 49365
city: Boulogne Billancourt
country: France
facility: Site Ref # / Investigator 49611
city: Bourg en Bresse
country: France
facility: Site Ref # / Investigator 49622
city: Brest
country: France
facility: Site Ref # / Investigator 49329
city: Caen
country: France
facility: Site Ref # / Investigator 49334
city: Cahors
country: France
facility: Site Ref # / Investigator 49358
city: Cannes
country: France
facility: Site Ref # / Investigator 49607
city: Carcassonne
country: France
facility: Site Ref # / Investigator 49612
city: Cherbourg
country: France
facility: Site Ref # / Investigator 49628
city: Clermont-Ferrand
country: France
facility: Site Ref # / Investigator 49613
city: Colombes
country: France
facility: Site Ref # / Investigator 49624
city: Compiegne
country: France
facility: Site Ref # / Investigator 49376
city: Corbeil Essonnes
country: France
facility: Site Ref # / Investigator 49356
city: Creteil
country: France
facility: Site Ref # / Investigator 49370
city: Dijon
country: France
facility: Site Ref # / Investigator 49605
city: Gleize
country: France
facility: Site Ref # / Investigator 49608
city: Gonesse
country: France
facility: Site Ref # / Investigator 49610
city: Grenoble
country: France
facility: Site Ref # / Investigator 49379
city: Grenoble
country: France
facility: Site Ref # / Investigator 49361
city: La Roche sur Yon
country: France
facility: Site Ref # / Investigator 49614
city: La Rochelle
country: France
facility: Site Ref # / Investigator 49601
city: Le Kremlin Bicetre
country: France
facility: Site Ref # / Investigator 49373
city: Le Mans
country: France
facility: Site Ref # / Investigator 49375
city: Libourne
country: France
facility: Site Ref # / Investigator 49325
city: Lievin
country: France
facility: Site Ref # / Investigator 49620
city: Lille
country: France
facility: Site Ref # / Investigator 49360
city: Limoges
country: France
facility: Site Ref # / Investigator 49623
city: Lomme
country: France
facility: Site Ref # / Investigator 49333
city: Lunel
country: France
facility: Site Ref # / Investigator 49355
city: Lyon
country: France
facility: Site Ref # / Investigator 49337
city: Lyon
country: France
facility: Site Ref # / Investigator 49363
city: Lyon
country: France
facility: Site Ref # / Investigator 49364
city: Mantes La Jolie
country: France
facility: Site Ref # / Investigator 49603
city: Marseilles
country: France
facility: Site Ref # / Investigator 49626
city: Marseilles
country: France
facility: Site Ref # / Investigator 49342
city: Marseilles
country: France
facility: Site Ref # / Investigator 49345
city: Marseilles
country: France
facility: Site Ref # / Investigator 49362
city: Montivilliers
country: France
facility: Site Ref # / Investigator 49330
city: Montpellier Cedex 5
country: France
facility: Site Ref # / Investigator 49323
city: Mulhouse
country: France
facility: Site Ref # / Investigator 5590
city: Nantes Cedex 1
country: France
facility: Site Ref # / Investigator 49374
city: Narbonne
country: France
facility: Site Ref # / Investigator 49642
city: Nice
country: France
facility: Site Ref # / Investigator 49353
city: Orange
country: France
facility: Site Ref # / Investigator 49618
city: Orleans
country: France
facility: Site Ref # / Investigator 49331
city: Paris Cedex 14
country: France
facility: Site Ref # / Investigator 49352
city: Paris
country: France
facility: Site Ref # / Investigator 49326
city: Paris
country: France
facility: Site Ref # / Investigator 49600
city: Paris
country: France
facility: Site Ref # / Investigator 49625
city: Paris
country: France
facility: Site Ref # / Investigator 49359
city: Pau
country: France
facility: Site Ref # / Investigator 49343
city: Pessac
country: France
facility: Site Ref # / Investigator 49344
city: Pierre Benite
country: France
facility: Site Ref # / Investigator 49606
city: Poissy
country: France
facility: Site Ref # / Investigator 49602
city: Poitiers
country: France
facility: Site Ref # / Investigator 49349
city: Provins
country: France
facility: Site Ref # / Investigator 49627
city: Reims
country: France
facility: Site Ref # / Investigator 49382
city: Rennes
country: France
facility: Site Ref # / Investigator 49328
city: Roubaix
country: France
facility: Site Ref # / Investigator 49619
city: Rouen
country: France
facility: Site Ref # / Investigator 49372
city: Saint Aubin Les Elbeuf
country: France
facility: Site Ref # / Investigator 49609
city: Saint Brieuc
country: France
facility: Site Ref # / Investigator 49327
city: Saint Maurice
country: France
facility: Site Ref # / Investigator 49336
city: Saint-Etienne
country: France
facility: Site Ref # / Investigator 49598
city: Strasbourg
country: France
facility: Site Ref # / Investigator 49346
city: Thionville
country: France
facility: Site Ref # / Investigator 49366
city: Toulon
country: France
facility: Site Ref # / Investigator 49616
city: Toulouse
country: France
facility: Site Ref # / Investigator 49322
city: Toulouse
country: France
facility: Site Ref # / Investigator 49348
city: Tours
country: France
facility: Site Ref # / Investigator 49324
city: Valence
country: France
facility: Site Ref # / Investigator 49617
city: Valenciennes
country: France
facility: Site Ref # / Investigator 49371
city: Vannes
country: France
facility: Site Ref # / Investigator 49629
city: Aachen
country: Germany
facility: Site Ref # / Investigator 49573
city: Berlin
country: Germany
facility: Site Ref # / Investigator 49454
city: Berlin
country: Germany
facility: Site Ref # / Investigator 49705
city: Berlin
country: Germany
facility: Site Ref # / Investigator 49480
city: Berlin
country: Germany
facility: Site Ref # / Investigator 49433
city: Bremen
country: Germany
facility: Site Ref # / Investigator 49577
city: Chemnitz
country: Germany
facility: Site Ref # / Investigator 49451
city: Cologne
country: Germany
facility: Site Ref # / Investigator 49551
city: Cottbus
country: Germany
facility: Site Ref # / Investigator 5602
city: Damp
country: Germany
facility: Site Ref # / Investigator 49441
city: Dresden
country: Germany
facility: Site Ref # / Investigator 49446
city: Dresden
country: Germany
facility: Site Ref # / Investigator 49474
city: Duisburg
country: Germany
facility: Site Ref # / Investigator 49483
city: Erfurt
country: Germany
facility: Site Ref # / Investigator 49455
city: Erlangen
country: Germany
facility: Site Ref # / Investigator 49579
city: Erlangen
country: Germany
facility: Site Ref # / Investigator 49475
city: Essen
country: Germany
facility: Site Ref # / Investigator 49481
city: Freiburg
country: Germany
facility: Site Ref # / Investigator 49469
city: Freiburg
country: Germany
facility: Site Ref # / Investigator 49711
city: Fuerth
country: Germany
facility: Site Ref # / Investigator 49556
city: Gyhum
country: Germany
facility: Site Ref # / Investigator 49482
city: Halle
country: Germany
facility: Site Ref # / Investigator 49422
city: Hamburg
country: Germany
facility: Site Ref # / Investigator 49468
city: Hamburg
country: Germany
facility: Site Ref # / Investigator 49552
city: Hattingen
country: Germany
facility: Site Ref # / Investigator 49466
city: Herrsching
country: Germany
facility: Site Ref # / Investigator 49544
city: Hildesheim
country: Germany
facility: Site Ref # / Investigator 49548
city: Hofheim
country: Germany
facility: Site Ref # / Investigator 49587
city: Jena
country: Germany
facility: Site Ref # / Investigator 49447
city: Leipzig
country: Germany
facility: Site Ref # / Investigator 49431
city: Ludwigsburg
country: Germany
facility: Site Ref # / Investigator 49424
city: Ludwigshafen
country: Germany
facility: Site Ref # / Investigator 49557
city: Marl
country: Germany
facility: Site Ref # / Investigator 49704
city: Moenchengladbach
country: Germany
facility: Site Ref # / Investigator 49547
city: Muenster
country: Germany
facility: Site Ref # / Investigator 49440
city: Munich
country: Germany
facility: Site Ref # / Investigator 49450
city: Munich
country: Germany
facility: Site Ref # / Investigator 49563
city: Passau
country: Germany
facility: Site Ref # / Investigator 49442
city: Ratingen
country: Germany
facility: Site Ref # / Investigator 49549
city: Rostock
country: Germany
facility: Site Ref # / Investigator 49708
city: Schlangenbad
country: Germany
facility: Site Ref # / Investigator 49558
city: Sendenhorst
country: Germany
facility: Site Ref # / Investigator 49445
city: Stuttgart
country: Germany
facility: Site Ref # / Investigator 49437
city: Tuebingen
country: Germany
facility: Site Ref # / Investigator 49560
city: Villingen
country: Germany
facility: Site Ref # / Investigator 49460
city: Vogelsang-Gommern
country: Germany
facility: Site Ref # / Investigator 49456
city: Wuerzburg
country: Germany
facility: Site Ref # / Investigator 49545
city: Wuppertal
country: Germany
facility: Site Ref # / Investigator 49449
city: Athens
country: Greece
facility: Site Ref # / Investigator 49580
city: Athens
country: Greece
facility: Site Ref # / Investigator 49568
city: Athens
country: Greece
facility: Site Ref # / Investigator 49584
city: Athens
country: Greece
facility: Site Ref # / Investigator 49554
city: Athens
country: Greece
facility: Site Ref # / Investigator 49565
city: Athens
country: Greece
facility: Site Ref # / Investigator 49583
city: Athens
country: Greece
facility: Site Ref # / Investigator 49585
city: Heraklion
country: Greece
facility: Site Ref # / Investigator 49564
city: Ioannina
country: Greece
facility: Site Ref # / Investigator 49567
city: Larisa
country: Greece
facility: Site Ref # / Investigator 49581
city: Patras
country: Greece
facility: Site Ref # / Investigator 26425
city: Thessaloniki
country: Greece
facility: Site Ref # / Investigator 49566
city: Thessaloniki
country: Greece
facility: Site Ref # / Investigator 49582
city: Thessaloniki
country: Greece
facility: Site Ref # / Investigator 49553
city: Thessaloniki
country: Greece
facility: Site Ref # / Investigator 49569
city: Acqui Terme (AL)
country: Italy
facility: Site Ref # / Investigator 49990
city: Arenzano (GE)
country: Italy
facility: Site Ref # / Investigator 49591
city: Bari
country: Italy
facility: Site Ref # / Investigator 49983
city: Bologna
country: Italy
facility: Site Ref # / Investigator 49593
city: Brescia
country: Italy
facility: Site Ref # / Investigator 49980
city: Cagliari
country: Italy
facility: Site Ref # / Investigator 49986
city: Ferrara
country: Italy
facility: Site Ref # / Investigator 50056
city: Florence
country: Italy
facility: Site Ref # / Investigator 49987
city: Foggia
country: Italy
facility: Site Ref # / Investigator 49597
city: Genoa
country: Italy
facility: Site Ref # / Investigator 49824
city: Genoa
country: Italy
facility: Site Ref # / Investigator 50051
city: Jesi (Ancona)
country: Italy
facility: Site Ref # / Investigator 49981
city: Messina
country: Italy
facility: Site Ref # / Investigator 49588
city: Milano
country: Italy
facility: Site Ref # / Investigator 49976
city: Milano
country: Italy
facility: Site Ref # / Investigator 50052
city: Milano
country: Italy
facility: Site Ref # / Investigator 49596
city: Modena
country: Italy
facility: Site Ref # / Investigator 49985
city: Naples
country: Italy
facility: Site Ref # / Investigator 49949
city: Novara
country: Italy
facility: Site Ref # / Investigator 49595
city: Padova
country: Italy
facility: Site Ref # / Investigator 49947
city: Palermo
country: Italy
facility: Site Ref # / Investigator 49948
city: Perugia
country: Italy
facility: Site Ref # / Investigator 49978
city: Pescara
country: Italy
facility: Site Ref # / Investigator 49974
city: Pisa
country: Italy
facility: Site Ref # / Investigator 49592
city: Potenza
country: Italy
facility: Site Ref # / Investigator 49992
city: Prato
country: Italy
facility: Site Ref # / Investigator 49822
city: Reggio Emilia
country: Italy
facility: Site Ref # / Investigator 49946
city: Rome
country: Italy
facility: Site Ref # / Investigator 49989
city: Rome
country: Italy
facility: Site Ref # / Investigator 49950
city: Rome
country: Italy
facility: Site Ref # / Investigator 50057
city: Rozzano
country: Italy
facility: Site Ref # / Investigator 49984
city: San Cesario Lecce
country: Italy
facility: Site Ref # / Investigator 49991
city: Torino
country: Italy
facility: Site Ref # / Investigator 49994
city: Udine
country: Italy
facility: Site Ref # / Investigator 49825
city: Valeggio sul Mincio Verona
country: Italy
facility: Site Ref # / Investigator 26422
city: Varese
country: Italy
facility: Site Ref # / Investigator 49594
city: Verbania Pallanza
country: Italy
facility: Site Ref # / Investigator 50055
city: Verona
country: Italy
facility: Site Ref # / Investigator 49589
city: Vimercate
country: Italy
facility: Site Ref # / Investigator 50053
city: Alkmaar
country: Netherlands
facility: Site Ref # / Investigator 49904
city: Almere
country: Netherlands
facility: Site Ref # / Investigator 49909
city: Amersfoort
country: Netherlands
facility: Site Ref # / Investigator 49831
city: Bergen op Zoom
country: Netherlands
facility: Site Ref # / Investigator 49906
city: Breda
country: Netherlands
facility: Site Ref # / Investigator 49907
city: Den Haag
country: Netherlands
facility: Site Ref # / Investigator 49905
city: Den Haag
country: Netherlands
facility: Site Ref # / Investigator 49920
city: Den Helder
country: Netherlands
facility: Site Ref # / Investigator 49910
city: Goes
country: Netherlands
facility: Site Ref # / Investigator 49902
city: Leeuwarden
country: Netherlands
facility: Site Ref # / Investigator 49829
city: Rotterdam
country: Netherlands
facility: Site Ref # / Investigator 26426
city: Rotterdam
country: Netherlands
facility: Site Ref # / Investigator 49830
city: Schiedam
country: Netherlands
facility: Site Ref # / Investigator 49908
city: Utrecht
country: Netherlands
facility: Site Ref # / Investigator 49827
city: Venlo
country: Netherlands
facility: Site Ref # / Investigator 49903
city: Vlissingen
country: Netherlands
facility: Site Ref # / Investigator 49835
city: Coimbra
country: Portugal
facility: Site Ref # / Investigator 49514
city: Lisboa
country: Portugal
facility: Site Ref # / Investigator 49515
city: Lisboa
country: Portugal
facility: Site Ref # / Investigator 49509
city: Lisbon
country: Portugal
facility: Site Ref # / Investigator 49510
city: Lisbon
country: Portugal
facility: Site Ref # / Investigator 49513
city: Ponta Delgada-Acores
country: Portugal
facility: Site Ref # / Investigator 49512
city: Ponte de Lima
country: Portugal
facility: Site Ref # / Investigator 26427
city: Alicante
country: Spain
facility: Site Ref # / Investigator 49653
city: Asturias
country: Spain
facility: Site Ref # / Investigator 49662
city: Barcelona
country: Spain
facility: Site Ref # / Investigator 49684
city: Barcelona
country: Spain
facility: Site Ref # / Investigator 49680
city: Barcelona
country: Spain
facility: Site Ref # / Investigator 49646
city: Barcelona
country: Spain
facility: Site Ref # / Investigator 49645
city: Barcelona
country: Spain
facility: Site Ref # / Investigator 49649
city: Barcelona
country: Spain
facility: Site Ref # / Investigator 49647
city: Barcelona
country: Spain
facility: Site Ref # / Investigator 49670
city: Cadiz
country: Spain
facility: Site Ref # / Investigator 49667
city: Cadiz
country: Spain
facility: Site Ref # / Investigator 49693
city: Castellon de la Plana
country: Spain
facility: Site Ref # / Investigator 5594
city: Cordoba
country: Spain
facility: Site Ref # / Investigator 49663
city: Elche
country: Spain
facility: Site Ref # / Investigator 49652
city: Granada
country: Spain
facility: Site Ref # / Investigator 49651
city: Granada
country: Spain
facility: Site Ref # / Investigator 49681
city: Guadalajara
country: Spain
facility: Site Ref # / Investigator 49695
city: Jaen
country: Spain
facility: Site Ref # / Investigator 49669
city: Lerida
country: Spain
facility: Site Ref # / Investigator 49689
city: Madrid
country: Spain
facility: Site Ref # / Investigator 49686
city: Madrid
country: Spain
facility: Site Ref # / Investigator 49697
city: Madrid
country: Spain
facility: Site Ref # / Investigator 49679
city: Madrid
country: Spain
facility: Site Ref # / Investigator 49650
city: Madrid
country: Spain
facility: Site Ref # / Investigator 49683
city: Madrid
country: Spain
facility: Site Ref # / Investigator 49687
city: Madrid
country: Spain
facility: Site Ref # / Investigator 49692
city: Madrid
country: Spain
facility: Site Ref # / Investigator 49664
city: Madrid
country: Spain
facility: Site Ref # / Investigator 49696
city: Malaga
country: Spain
facility: Site Ref # / Investigator 49665
city: Malaga
country: Spain
facility: Site Ref # / Investigator 49691
city: Mostoles-Madrid
country: Spain
facility: Site Ref # / Investigator 49685
city: Sant Joan Despi (Barcelona)
country: Spain
facility: Site Ref # / Investigator 49666
city: Seville
country: Spain
facility: Site Ref # / Investigator 49688
city: Toledo
country: Spain
facility: Site Ref # / Investigator 49694
city: Valencia
country: Spain
facility: Site Ref # / Investigator 49654
city: Vic (Barcelona)
country: Spain
facility: Site Ref # / Investigator 49648
city: Brighton
country: United Kingdom
facility: Site Ref # / Investigator 49485
city: Greater Manchester
country: United Kingdom
facility: Site Ref # / Investigator 49470
city: Harrogate
country: United Kingdom
facility: Site Ref # / Investigator 49471
city: Manchester
country: United Kingdom
facility: Site Ref # / Investigator 49476
city: Oxford
country: United Kingdom
facility: Site Ref # / Investigator 49486
city: Wigan
country: United Kingdom
facility: Site Ref # / Investigator 49472
Study officials:
affiliation: Abbott
name: Laura Redden, MD, PhD
role: STUDY_DIRECTOR
References:
citation: Burmester GR, Matucci-Cerinic M, Mariette X, Navarro-Blasco F, Kary S, Unnebrink K, Kupper H. Safety and effectiveness of adalimumab in patients with rheumatoid arthritis over 5 years of therapy in a phase 3b and subsequent postmarketing observational study. Arthritis Res Ther. 2014 Jan 27;16(1):R24. doi: 10.1186/ar4452.