Clinical trial NCT06840743: Do Emotions and Pain Combined Affect Mechanical Pain Thresholds and Other Pain-related Variables
Official title: Do Emotions and Pain Combined Affect Mechanical Pain Thresholds and Other Pain-related Variables
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Pain Thresholds
Keywords: Pressure Pain Thresholds
Pain
Emotions
Lead sponsor: Linnaeus University
Sponsor class: OTHER
First posted: 2025-02-21
Enrollment: 180
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: PARALLEL
Intervention model description: Within-subjects design
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to investigate if different emotional states could influence mechanical pain thresholds and other pain - related variables such as pain tolerance, pain intensity and pain - related negative affect.

Detailed description: Participants will be randomized into 4 different groups watching different short video-clips (2.20 min), while at the same time experience short-lasting, experimentally induced pain. The negative emotions group will watch an uncomfortable short video containing violence and blood, the positive emotions group will watch a video containing a stand-up comedy show, the neutral emotions group will watch a video about how to paint a house, and the control group will just wait for 2.20 min, without any instructions about what to think about. Pressure pain thresholds will be measured with an algometer before and after the video-clip combined with experimental pain interventions.

Eligibility criteria: Inclusion Criteria:

* Above 18 years of age
* Fluent in Swedish.

Exclusion Criteria:

* Pain anywhere in body during the test session
* Known neurological disease.

Primary outcomes:
measure: Pressure pain thresholds (PPTs)
timeFrame: For each participant, baseline PPTs are measured, intervention follows and intervention PPTs are measured. This will be conducted at one appointment (30 min) for each participant. Recruitment for single appointments will take place for 18 months.
Secondary outcomes:
measure: Pain tolerance (time in seconds the left hand is immersed in cold water 1 degree C).
timeFrame: At a single session (30 min), the participant will keep their hand immersed in cold water for as long as possible while watching a video. This time will be measured in seconds. Participants are successively recruited for single appointmentsfor 18 months.
measure: Pain intensity on the NRS
timeFrame: The pain intensity will be estimated at every single session appointment (30 min) after the intervention on the NRS (Numerical Rating Scale). The participants will be successively recruited for single session appointments for 18 months.
measure: Pain-related negative affect on the NRS-A
timeFrame: Negative affect will be estimated at every single test session (30 min) on the NRS-A (Numerical Rating Scale-Anxiety) directly after the intervention. The participants will be successively recruited for single session appointments during 18 months.
Other outcomes:
Locations:
city: Växjö
country: Sweden
facility: Linnaeus University
Study officials:
References: