Clinical trial NCT04797546: Adductor Canal Block Versus Patient Controlled Analgesia, in the Surgical Stress Response for Anterior Cruciate Ligament Repair
Official title: Impact of Adductor Canal Block, Compared to Patient Controlled Analgesia, in the Surgical Stress Response of Patients Programmed for Traumatic Anterior Cruciate Ligament Repair
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE1
Conditions: Anesthesia
Stress, Physiological
Surgery
Lead sponsor: Pontificia Universidad Catolica de Chile
Sponsor class: OTHER
First posted: 2021-03-15
Enrollment: 0
Sex: MALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the surgical stress response in anterior cruciate ligament repair with an adductor canal block versus patient controlled endovenous analgesia.

Detailed description: Preoperative, 2 hours and 24 hours stress biomarkers will be evaluated in two groups of patients, continous adductor canal block and morphine patient controlled endovenous analgesia.

Eligibility criteria: Inclusion Criteria:

* Male,
* 18-65 years,
* traumatic Anterior Cruciate Ligament tear, scheduled for elective arthroscopic repair with Semitendinous-Gracillis technique at first time in the morning, with full articular range,
* no other traumatologic lesions.

Exclusion Criteria:

* denied consent to participate,
* chronic steroids user,
* diabetes type 1 or 2,
* insulin resistance,
* concurrent infectious disease,
* cognitive failure, coagulopathy,
* allergy to study drugs,
* surgery scheduled in the afternoon

Primary outcomes:
measure: Change of Blood Cortisol from baseline to 24 hours
timeFrame: 24 hours
Secondary outcomes:
measure: Change of C Reactive Protein from baseline to 24 hours
timeFrame: 24 hours
measure: Change of Glycemia from baseline to 24 hours
timeFrame: 24 hours
Other outcomes:
Locations:
city: Santiago
country: Chile
facility: Pontificia Universidad Católica de Chile
Study officials:
affiliation: PUC
name: Fernando Altermatt, MD
role: PRINCIPAL_INVESTIGATOR
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