Clinical trial NCT06980779: The Correlation of Clinical and Ultrasonographic Findings in Dorsoradial Wrist Pain Patients: Cross Sectional Study
Official title: The Correlation of Clinical and Ultrasonographic Findings in Dorsoradial Wrist Pain Patients: Cross Sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carpometacarpal (CMC) Joint Arthritis
Ganglion Cyst
De Quervain Disease
Radial Neuropathy
Keywords: carpometacarpal joint arthritis
ultrasonography
dorsoradial wrist pain
de Quervain disease
intersection syndrome
ganglion cyst
Lead sponsor: Fatih Sultan Mehmet Training and Research Hospital
Sponsor class: OTHER
First posted: 2025-05-20
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: patients who referred physical theraphy and rehabilitation and orthopedia clinics with dorsoradial wrist and thumb pain

Brief summary: This study aims to investigate the correlation between ultrasonographic and clinical findings in dorsoradial wrist pain. There are several etiologies for dorsoradial wrist pain, including carpometacarpal joint arthritis, De Quervain's tenosynovitis, proximal and distal intersection syndrome, Wartenberg syndrome, and ganglion cysts. In these clinical scenarios, certain physical examination tests are utilized, such as the Finkelstein test for De Quervain's tenosynovitis; however, this test may also yield positive results in cases of severe joint arthritis. Ultrasonography is proposed as a complementary tool for differential diagnosis. The investigators aim to examine the correlation between clinical test results and ultrasonographic parameters such as tendon thickness in the first extensor compartment, carpometacarpal joint synovitis, cortical irregularities, and the presence of osteophytes. Functional status will be assessed using the QuickDASH and FIHOA questionnaires.

Detailed description: In the assessment of the first carpometacarpal (CMC) joint, the following ultrasonographic parameters will be evaluated: synovitis, presence of osteophytes, joint surface irregularity, and Doppler signal activity. Additionally, conventional hand radiographs of all participants will be reviewed to support the imaging findings.

For the evaluation of De Quervain's tenosynovitis, tendon sheath thickness, tendon cross-sectional area, and intratendinous Doppler activity will be measured. At the anatomical intersection zones of the first dorsal compartment, the presence of peritendinous fluid and associated Doppler activity will also be assessed to identify potential sites of friction or inflammation.

Assessment of the superficial radial nerve will include measurement of its cross-sectional area. A cross-sectional area exceeding one square millimeter will be considered indicative of possible neuropathy.

Eligibility criteria: Inclusion Criteria:

* pain in dorsoradial wrist

Exclusion Criteria:

* known rheumatological disease
* history of forearm, wrist, hand fracture
* history of forearm, wrist, hand operation
* mental retardation
* history of major trauma in forearm, wrist and hand
* fibromyalgia

Primary outcomes:
measure: Odds Ratio of First Extensor Compartment Tendon Sheath Thickness Associated with De Quervain Disease
timeFrame: At the time of enrollment
measure: Odds Ratio of Synovial Hypertrophy in CMC Joint Associated with Carpometacarpal Arthritis
timeFrame: At the time of enrollment
measure: Sensitivity of Ultrasonographic Parameters for Diagnosing Dorsoradial Wrist Pathologies
timeFrame: At the time of enrollment
measure: Specificity of Ultrasonographic Parameters for Diagnosing Dorsoradial Wrist Pathologies
timeFrame: At the time of enrollment
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: University of Health Sciences, FSM Training and Research Hospital, Istanbul
state: Ataşehir
Study officials:
affiliation: University of Health Sciences, FSM Training and Research Hospital, Istanbul
name: Ilkyaz Yağar, Resident
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Health Sciences, FSM Training and Research Hospital, Istanbul
name: Esra Giray, Associated Professor
role: STUDY_DIRECTOR
affiliation: University of Health Sciences, FSM Training and Research Hospital, Istanbul
name: Aslınur Keleş
role: STUDY_CHAIR
affiliation: University of Health Sciences, FSM Training and Research Hospital, Istanbul
name: Feyza Unlu Ozkan, Professor
role: STUDY_CHAIR
affiliation: University of Health Sciences, FSM Training and Research Hospital, Istanbul
name: Ilknur Aktas, Professor
role: STUDY_CHAIR
affiliation: University of Health Sciences, FSM Training and Research Hospital, Istanbul
name: Ozge Gulsum Illeez, Associated Professor
role: STUDY_CHAIR
References:
citation: McBain B, Rio E, Cook J, Grabinski R, Docking S. Diagnostic accuracy of imaging modalities in the detection of clinically diagnosed de Quervain's syndrome: a systematic review. Skeletal Radiol. 2019 Nov;48(11):1715-1721. doi: 10.1007/s00256-019-03195-z. Epub 2019 Mar 19.
citation: Montechiarello S, Miozzi F, D'Ambrosio I, Giovagnorio F. The intersection syndrome: Ultrasound findings and their diagnostic value. J Ultrasound. 2010 Jun;13(2):70-3. doi: 10.1016/j.jus.2010.07.009. Epub 2010 Sep 19.
citation: Look N, Mcnulty M, Rodriguez-Fontan F, Fenoglio AK. Radial-sided wrist pain differentials: presentation, pathoanatomy, diagnosis, and management. Medicina (B Aires). 2023;83(1):96-107.