Clinical trial NCT03540602: Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise
Official title: Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Muscle Soreness
Keywords: Polyphenol rich supplementation
Tart cherry
Lifting
Recovery
Lead sponsor: Jacksonville University
Sponsor class: OTHER
Collaborators: name: Specnova, inc
First posted: 2018-05-30
Enrollment: 20
Sex: MALE
Minimum age (years): 21
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: 20 male participants will start with a familiarization visit where they will receive either the placebo supplement or the polyphenol rich supplement that they will take for 7 days. After taking the supplement, the participants will come back and run through the acute resistance exercise protocol as well as return the next day for a post test. Next, the participants will undergo a "wash out" phase where they will not take any supplementation. At the end of these 2 weeks, the participants will then take the other supplement (i.e. if they took the polyphenol rich supplement in the first phase they will take the placebo supplement in the second phase). After a week of taking their assigned supplement, participants will complete the acute resistance exercise protocol and the post test.
Primary purpose: BASIC_SCIENCE

Brief summary: Strength training is commonly used as an intervention to increase muscle mass, thus improving a person's ability to undertake activities of daily living, or enhance athletic performance. The strength training regimen itself, while ultimately having beneficial effects, causes muscle fibers to be damaged, which the body has to recover from. As the body recovers, it rebuilds the muscle tissue and after multiple consecutive bouts of strength training, the muscle eventually becomes larger and stronger. Thus, it is the recovery from strength training exercise that ultimately determines how well the body adapts. Where inadequate recovery could eventually lead to overtraining and/or injury, optimizing the recovery process from strength training could maximize strength training adaptations. This concept of optimizing recovery has led to development of many supplements, including antioxidants, which may reduce the damage associated with strength training activities and therefore enhance positive adaptations. The purpose of this study is to assess the ability of a polyphenol rich supplementation to aid the recovery process from a demanding bout of resistance exercise


Eligibility criteria: Inclusion Criteria:

* 6 months of resistance training experience with barbel back squat exercise

Exclusion Criteria:

* Not currently taking any antioxidant supplements, not currently using any hormone replacement therapy or anabolic androgenic steroids.

Primary outcomes:
measure: Assessment of Oxidative Stress
timeFrame: 7 weeks
Secondary outcomes:
measure: Muscle soreness
timeFrame: 7 weeks
measure: Vertical Jump Performance
timeFrame: 7 weeks
Other outcomes:
Locations:
city: Jacksonville
country: United States
facility: Jacksonville University
state: Florida
Study officials:
affiliation: Jacksonville University
name: Heather Hausenblaus
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Alessio HM, Goldfarb AH, Cutler RG. MDA content increases in fast- and slow-twitch skeletal muscle with intensity of exercise in a rat. Am J Physiol. 1988 Dec;255(6 Pt 1):C874-7. doi: 10.1152/ajpcell.1988.255.6.C874.
citation: Blair SN, Cheng Y, Holder JS. Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc. 2001 Jun;33(6 Suppl):S379-99; discussion S419-20. doi: 10.1097/00005768-200106001-00007.
citation: Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 2008 Oct;88(4):1243-76. doi: 10.1152/physrev.00031.2007.