Clinical trial NCT04333550: Application of Desferal to Treat COVID-19
Official title: Application of Iron Chelator (Desferal) to Reduce the Severity of COVID-19 Manifestations
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: COVID-19
Keywords: COVID-19, Deferoxamine
Lead sponsor: Kermanshah University of Medical Sciences
Sponsor class: OTHER
First posted: 2020-04-03
Enrollment: 50
Sex: ALL
Minimum age (years): 3
Maximum age (years): 99
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study, defined cases of COVID-19 with mild, moderate or severe pneumonia will be treated with standard treatment regimens in combination with IV injection of Deferoxamine. Improvement in clinical, laboratory and radiological manifestations will be evaluated in treated patient compared to control group.


Eligibility criteria: Inclusion Criteria:

Clinical diagnosis of COVID-19 Disease,

Exclusion Criteria:

Previous history of allergy to Deferoxamin, Pregnancy, kidney dysfunction,

Primary outcomes:
measure: Mortality rate
timeFrame: up to 20 days
Secondary outcomes:
measure: change in patients clinical manifestation
timeFrame: up to 20 days
measure: change in patients PaO2
timeFrame: up to 20 days
measure: Length of hospitalization
timeFrame: up to 20 days
measure: C-reactive protein
timeFrame: up to 20 days
measure: lymphocyte count
timeFrame: up to 20 days
measure: length of intensive care unit stay
timeFrame: 1 to 20 days
Other outcomes:
Locations:
city: Kermanshah
country: Iran, Islamic Republic of
facility: Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Study officials:
affiliation: Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
name: Yadollah Shakiba, MD, PhD
role: STUDY_DIRECTOR
affiliation: Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
name: Amir Kiani, PhD
role: PRINCIPAL_INVESTIGATOR
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