Clinical trial NCT04669184: Sarcopenia and Physical Performance in Hemodialysis Patients
Official title: Assessment of Sarcopenia, Physical Performance and Cognitive Function in Hemodialysis Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: End Stage Kidney Disease
Keywords: sarcopenia
pain
physical performance
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2020-12-16
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients aged 18 years and older, who are diagnosed with end stage kidney disease at the Hacettepe University, Faculty of Medicine, Department of Internal Diseases, Nephrology Subdivision

Brief summary: Many systems such as the cardiovascular, pulmonary, musculoskeletal, hematological, immunological, gastrointestinal, central nervous system are affected due to decreased kidney function. The aim of this study was to investigate the relationship between physical performance and sarcopenia, peripheral muscle strength, activities of daily living, cognitive functions, physical activity level, fragility, pain in hemodialysis patients.

Detailed description: A high prevalence of sarcopenia has been reported in end stage kidney disease. The incidence of sarcopenia increases with age. Muscle atrophy is caused by an imbalance between the anabolic and catabolic processes in chronic kidney disease. Sarcopenia and physical inactivity progress synergistically. Decreased physical performance is associated with sarcopenia. In hemodialysis patients, daily physical activity level and physical performance decrease. Cognitive impairment is common in chronic kidney disease. Uremic toxins can cause a decrease in cognitive function. One of the most important problems associated with hemodialysis is pain and pain negatively affects functional capacity and quality of life.

Eligibility criteria: Inclusion Criteria:

* Having been diagnosed with end stage kidney disease
* Receiving hemodialysis for more than 3 months
* Being clinically stable
* Volunteering to participate in the research

Exclusion Criteria:

* Having an orthopedic disease that may affect functional capacity
* Having cardiac event in the past 3 months

Primary outcomes:
measure: Sarcopenia
timeFrame: 5 minutes
measure: Physical performance will be evaluated using Short physical performance battery.
timeFrame: 10 minutes
measure: Physical performance will be evaluated using 1 minute sit to stand test.
timeFrame: 5 minutes
measure: Pain level
timeFrame: 5 minutes
Secondary outcomes:
measure: Peripheral muscle strength
timeFrame: 5 minutes
measure: Cognitive function
timeFrame: 10 minutes
measure: Physical activity level
timeFrame: 5 minutes
measure: Fragility
timeFrame: 5 minutes
measure: Activities of daily living
timeFrame: 10 minutes
Other outcomes:
Locations:
Study officials:
affiliation: Hacettepe University
name: Merve Firat, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: Hacettepe University
name: Naciye Vardar-Yagli, PhD
role: STUDY_DIRECTOR
affiliation: Hacettepe University
name: Deniz İnal-İnce, Professor
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Tolga Yildirim, MD
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Melda Saglam, PhD
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Ebru Calik-Kütükcü, PhD
role: STUDY_CHAIR
References: