Clinical trial NCT01958190: Study Comparing in Livertransplantation Recipients With Tacrolimus Alone Versus Tacrolimus&Sirolimus
Official title: A Multicenter Randomized in Primary Livertransplantation Comparing Longterm Renal Function in Recipients Treated With Tacrolimus Alone and Recipients Treated With a Combination Tacrolimus and Sirolimus
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Liver Disease
Keywords: Liver transplantation long term renal function
tacrolimus sirolimus
Lead sponsor: Foundation for Liver Research
Sponsor class: OTHER
First posted: 2013-10-09
Enrollment: 196
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study we compare long term renal function in liver transplantation recipients treated with standard dose extended-release tacrolimus alone and recipients treated with a combination of low dose extended-release tacrolimus and low dose sirolimus. The hypothesis is that the patients treated with the combination have better long term renal function than the patients treated with standard dose tacrolimus alone.

Detailed description: To evaluate the effectiveness and safety of concentration controlled combination of once daily dosed low-dose sirolimus (trough levels: 3-5 ng/ml) and extended-release tacrolimus (trough levels:3-5 ng/ml), in order to provide superior renal function while maintaining comparable rates of patient and graft survival, compared to concentration controlled once - daily extended release tacrolimus (trough levels: 5-10 ng/ml) at 12, 24 and 36 months post-transplant. Moreover, to compare the incidence of de novo malignancy, the quality of life, fatigue and side effects between both treatment arms.

2.1 Primary objectives: To evaluate the effectiveness and safety of concentration controlled combination of low-dose sirolimus (trough levels: 3-5 ng/ml) and extended-release tacrolimus (trough levels: 3-5 ng/ml), in order to provide superior renal function while maintaining comparable rates of patient and graft survival, compared to concentration controlled once - daily extended release tacrolimus (trough levels:-10 ng/ml) control at 12, 24 and 36 months post-transplant.

2.2. Secondary objectives:

* To compare the incidence of de novo and recurrence of cancer between study arm and control arm at 36 months.
* To compare the incidence and severity of biopsy proven acute rejection between study arm and control arm at 12, 24 and 36 months.
* To evaluate renal function at 12, 24 and 36 months (calculated GFR).
* To evaluate the development of new onset diabetes mellitus at 12, 24 and 36 months post transplant
* To evaluate the prevalence of CNI side effects at 12, 24 and 36 months
* To evaluate quality of life (Eq5D) and fatigue severity score at 12, 24 and 36 months
* To evaluate the percentage of patients on combination tacrolimus and sirolimus and converted back to tacrolimus mono-therapy.

Eligibility criteria: Inclusion Criteria:

* Primary liver transplantation or retransplantation within 14 days after first transplantation
* Use of Advagraf at least 2 weeks prior to randomization
* Patent hepatic artery
* Closed abdominal wound
* Stable graft function
* Positive informed consent at time of randomization
* Age 18-70 years

Exclusion Criteria:

* Treatment with investigational drugs within 3 months before start of therapy
* Multi organ transplantation
* cGFR \< 30 ml/min
* Proteinuria \> 800 mg/24 h
* Hyperlipidemia refractory to optimal medical management (Cholesterol \> 9 mmol/l and/or triglycerides \> 8.5 mmol/l). Patients with controlled hyperlipidemia are acceptable at the time of randomization.
* Known hypersensitivity to sirolimus or its derivatives
* Thrombocytes \< 50 x 109 /L
* Leukocytes \< 2.5 x 109 /L
* Haemoglobin \< 6 mmol/L
* Biopsy proven rejection 2 weeks prior to randomization
* HIV positivity
* Signs of recurrent or de novo cancer
* Patients with non-HCC malignancies within the past 5 years (excluding successfully treated squamous cell carcinoma and basal cell carcinoma of the skin)
* Evidence of significant local or systemic infection
* Pregnancy or breast feeding
* Women of child-bearing potential not willing to take oral contraception
* Any other condition which in the opinion of the investigator would make the patient unsuitable for enrollment, or could interfere with the patient participating in and completing the study

Primary outcomes:
measure: Renal function
timeFrame: 3 years
Secondary outcomes:
measure: Malignancies
timeFrame: 3 years
measure: Diabetes Mellitus
timeFrame: 3 years
Other outcomes:
Locations:
city: Groningen
country: Netherlands
facility: UMCG
city: Leiden
country: Netherlands
facility: LUMC
city: Rotterdam
country: Netherlands
facility: Erasmus Medical Center
Study officials:
affiliation: Erasmus Medical Center
name: Herold J Metselaar, MD PhD
role: PRINCIPAL_INVESTIGATOR
References: