Clinical trial NCT00427843: The Influence of Hip Strengthening Exercises on Walking Patterns and Muscle Strength in Persons With Knee Osteoarthritis
Official title: The Influence of a Home Program of Hip Abductor Exercises on Gait Parameters and Muscle Strength in Persons With Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteoarthritis, Knee
Keywords: osteoarthritis
knee
gait
muscle strength
hip
exercise
Lead sponsor: Queen's University
Sponsor class: OTHER
First posted: 2007-01-29
Enrollment: 80
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the influence of a home program of exercises for the hip muscles which support the pelvis on walking patterns and hip muscle strength in people with knee osteoarthritis. Following a hip muscle strengthening program, we hypothesize that participants with knee osteoarthritis will demonstrate decreased loading at the knee joint during walking and greater strength of the hip muscles.

Detailed description: Knee osteoarthritis is a common age-related impairment that may progress to cause significant pain and physical disability. Excessive loading at the knee joint is believed to contribute to the progression of knee osteoarthritis. The hip joint and surrounding muscles have been shown to influence the amount of stress occurring at the knee joint during walking. In particular, the hip abductor muscles may have an effect on the knee joint by controlling the position of the pelvis and/or by acting as lateral stabilizers for the knee.

Research suggests that the function of the hip muscles during walking may be decreased in people with knee osteoarthritis and that greater loads may be placed on the knee joint as a result. Thus, interventions aimed at strengthening the hip abductor muscles may be effective for reducing stress on the arthritic knee and slowing the rate of progression of knee osteoarthritis.

The design of the study is a two-group pretest-posttest design using an untreated control group. Thirty-five individuals with medial compartment knee osteoarthritis will be recruited through newspaper advertisements and from the practices of orthopedic surgeons in Kingston, Ontario. Each participant with knee osteoarthritis will be matched with an asymptomatic volunteer for age (+/- 5 years), height (+/- 5 cm), mass (+/- 5 kg) and gender. Participants in the control group will have no clinical or radiographic diagnosis of knee or hip osteoarthritis or rheumatoid arthritis and no history of hip or knee trauma or pain.

Eligibility criteria: Inclusion Criteria:

* age greater than or equal to 40 years
* self-reported pain in the knee(s) for most days of the month
* at least some difficulty in daily function due to knee osteoarthritis
* radiographic evidence of knee osteoarthritis or documented evidence of cartilage loss in the knee by arthroscopy surgery or magnetic resonance imaging.

Exclusion Criteria:

* corticosteroid injection into either knee within the previous three months
* other significant medical problems (including significant heart disease, stroke and active treatment for cancer) that would prevent participants from being able to perform a hip exercise program or to participate in tests of walking performance and hip muscle strength
* known osteoarthritis or previous trauma affecting one or both hips
* previous replacement of any joint in the lower extremities.
* receiving rehabilitation services for knee osteoarthritis or performing a hip strengthening program at the time of testing
* participants who have had a dual-energy x-ray absorptiometry (DEXA) for bone density analysis or more than one x-ray of the chest, abdomen or hip in the past 6 months

Primary outcomes:
measure: Walking variables: hip and knee abductor and adductor moments
timeFrame: baseline and after 8 weeks
measure: Muscle strength measures: isometric and isokinetic peak torque measures for the hip abductor and adductor muscles
timeFrame: baseline and after 8 weeks
Secondary outcomes:
measure: Radiographs: lower limb frontal plane alignment measures - limb alignment in degrees; grading of knee osteoarthritis severity (total score out of 13)
timeFrame: baseline
measure: Speed of performance on the Five-Times-Sit-to-Stand Test
timeFrame: baseline and after 8 weeks
measure: Total score on the WOMAC pain subscale and the WOMAC physical function subscale
timeFrame: baseline and after 8 weeks
measure: Total score obtained for the physical activity scale (PASE)
timeFrame: baseline and after 8 weeks
Other outcomes:
Locations:
city: Kingston
country: Canada
facility: School of Rehabilitation Therapy, Queen's University
state: Ontario
Study officials:
affiliation: Queen's University
name: Elsie G. Culham, PhD
role: STUDY_DIRECTOR
References:
citation: Sled EA, Khoja L, Deluzio KJ, Olney SJ, Culham EG. Effect of a home program of hip abductor exercises on knee joint loading, strength, function, and pain in people with knee osteoarthritis: a clinical trial. Phys Ther. 2010 Jun;90(6):895-904. doi: 10.2522/ptj.20090294. Epub 2010 Apr 8.