Clinical trial NCT01517503: Acceptance and Commitment Therapy Versus Cognitive Therapy for the Treatment of Major Depressive Disorder
Official title: Acceptance and Commitment Therapy vs. Cognitive Therapy for the Treatment of Major Depressive Disorder
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Major Depressive Disorder
Lead sponsor: VU University of Amsterdam
Sponsor class: OTHER
First posted: 2012-01-25
Enrollment: 82
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study will investigate the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with Major Depressive Disorder in routine clinical practice. Furthermore, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism.

Detailed description: The current study aims at investigating the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with MDD in routine clinical practice. Further, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism. Patients have to meet diagnostic criteria for nonpsychotic MDD as determined by the Structured Interview for DSM-IV. Each client will receive either Cognitive Therapy or Acceptance and Commitment Therapy that will last between 16 to 20 sessions. Based on previous results, it is expected that both treatment forms will prove beneficial for the patients.

Eligibility criteria: Inclusion Criteria:

1. Meeting DSM-IV criteria for MDD
2. Between the ages of 18 and 65-years-old
3. Having sufficient fluency in Dutch to complete treatment and research protocol

Exclusion Criteria:

1. DSM-IV criteria for bipolar disorder (past or present)
2. Psychotic disorders
3. Substance dependence disorders (current or within the past 6 months), or
4. Organic brain syndrome.
5. Borderline or antisocial personality disorder

Primary outcomes:
measure: QUICK INVENTORY OF DEPRESSIVE SYMPTOMATOLOGY (QIDS-SR)
timeFrame: pre-treatment, post-treatment, 6 and 12 months follow-up
measure: Hamilton Rating Scale for Depression
timeFrame: pre-treatment, post-treatment
Secondary outcomes:
measure: Decentering subscale of the Experiences Questionnaire
timeFrame: Pre-treatment, in-treatment, and 6 and 12 months follow-up.
measure: Acceptance and Action Questionnaire
timeFrame: Pre-treatment, in-treatment, and 6 and 12 months follow-up.
measure: Dysfunctional Attitude Scale-revised
timeFrame: Pre-treatment, in-treatment, and 6 and 12 months follow-up
measure: Working Alliance Inventory
timeFrame: 3. session
measure: Eurohis Quality of Life Scale
timeFrame: Pre-, post-treatment, 6 and 12 months follow-up
measure: Relationship Scales
timeFrame: Pre-, post-treatment, 12 months follow-up
measure: Implicit Attitude Test
timeFrame: Pre- and posttreatment
measure: Structured Clinical Interview for DSM-IV (Major Depression Module)
timeFrame: Pre-treatment and post-treatment.
Other outcomes:
Locations:
city: Zaandam
country: Netherlands
facility: PsyQ
Study officials:
affiliation: University of Amsterdam
name: Paul MG Emmelkamp, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Amsterdam
name: Nexhmedin Morina, PhD
role: STUDY_DIRECTOR
References:
citation: A-Tjak JGL, Morina N, Topper M, Emmelkamp PMG. One year follow-up and mediation in cognitive behavioral therapy and acceptance and commitment therapy for adult depression. BMC Psychiatry. 2021 Jan 14;21(1):41. doi: 10.1186/s12888-020-03020-1.
citation: A-Tjak JGL, Morina N, Boendermaker WJ, Topper M, Emmelkamp PMG. Explicit and implicit attachment and the outcomes of acceptance and commitment therapy and cognitive behavioral therapy for depression. BMC Psychiatry. 2020 Apr 7;20(1):155. doi: 10.1186/s12888-020-02547-7.