Clinical trial NCT05674955: CWT Versus AT on Selected Cardiovascular Indices and Functional Capacity in Patients With Ischemic Cardiomyopathy.
Official title: Circuit Weight Versus Aerobic Training on Selected Cardiovascular Indices and Functional Capacity in Patients With Ischemic Cardiomyopathy.
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Ischemic Cardiomyopathy
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-01-09
Enrollment: 60
Sex: MALE
Minimum age (years): 45
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 3 groups of ischemic cardiomyopathy patients. 1st group receive circuit weight training. 2nd group receive aerobic. 3rd group receive medications
Primary purpose: TREATMENT

Brief summary: To compare between the effect of circuit weight and aerobic training on selected cardiovascular indices and functional capacity in patients with ischemic cardiomyopathy.

Detailed description: Ischemic cardiomyopathy (ICM) is a term that refers to the heart's decreased ability to pump blood properly due to myocardial damage brought upon by ischemia. Ischemic cardiomyopathy has a spectrum of clinical changes which eventually leads to congestive heart failure (CHF). Initially, there is a reversible loss of cardiac contractile function because of decreased oxygen supply to the heart muscle; however, when there is ischemia for a prolonged period, there is irreversible cardiac muscle damage resulting in cardiac remodeling. Remodeling is primarily achieved by myocardial fibrosis which results in decreased cardiac function, arrhythmia, and possible cardiac conduction system impairment. In ischemic cardiomyopathy, there is a significant impairment of the left ventricular systolic function, with a left ventricular ejection fraction (LVEF) less than 40% (Bhandari et al., 2021).

Eligibility criteria: Inclusion Criteria:

* Sixty male patients with ischemic cardiomyopathy as a result of a recent acute myocardial infarction event (≤2 months) with 40%\<LVEF\<50%.
* They are functionally classified as class II according to New York Heart Association (NYHA).
* Their age will be ranged from 45 to 55 years old.
* Their BMI will be ranged from 25 to 29.9 kg/m².
* They will have good mentality.

Exclusion Criteria:

* Recurrent coronary heart disease.
* Severe valvular diseases.
* Underlying pulmonary disease (aspiration pneumonia, chronic obstructive pulmonary disease, pneumothorax, etc.).
* Inability to ambulate owing to physical problems (paresis induced by cerebral stroke, spinal cord injury, amputation, severe pain, dyspnea, etc.).
* muskloskletal problems (e.g. severe osteoarthritis or ankylosing spondylitis).
* Impaired cognitive function (vascular dementia, Alzheimer's dementia, other psychological disease, etc.)

Primary outcomes:
measure: Ejection fraction
timeFrame: 2 months
Secondary outcomes:
measure: Blood pressure
timeFrame: 2 months
Other outcomes:
Locations:
Study officials:
References:
citation: Nishi I, Noguchi T, Iwanaga Y, Furuichi S, Aihara N, Takaki H, Goto Y. Effects of exercise training in patients with chronic heart failure and advanced left ventricular systolic dysfunction receiving beta-blockers. Circ J. 2011;75(7):1649-55. doi: 10.1253/circj.cj-10-0899. Epub 2011 May 25.