Clinical trial NCT06858943: Can Tendon Autograft Function As a Meniscal Transplant
Official title: Can Tendon Autograft Function As a Meniscal Transplant
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Meniscectomy
Keywords: Meniscus ; Peroneus longus autograft
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-03-05
Enrollment: 25
Sex: ALL
Minimum age (years): 22
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: case series of 25 patients
Primary purpose: TREATMENT

Brief summary: Purpose: To evaluate the functional outcomes after using peroneus longus (PL) tendon autograft as meniscal transplantation in patients with knee joint line pain exaggerated with weight bearing following prior total or subtotal meniscectomy.

Detailed description: This research design is a single center prospective study carried out at a tertiary trauma center hospital between May 2022 and December 2022. This research had ethical Committee Approval which was granted by the Ethics Committee of Cairo University (Institutional Review Board (IRB) number N 207-2024). All patients signed an informed consent before joining this study. This study included 25 patients, with previous history of subtotal or total meniscectomy medially or laterally, who underwent meniscus transplantation using PL tendon autograft.

Eligibility criteria: Inclusion Criteria:

* Skeletally mature patients with a history of prior subtotal or total (medial or lateral meniscus) meniscectomy.
* Post meniscectomy symptoms (medial or lateral knee joint line pain exaggerated with weight bearing).

Exclusion Criteria:

* Multi-ligamentous knee injuries.
* Skeletally immature patients.
* Significant osteoarthritic changes on radiographs (Ahlbäck II- V).
* Malalignment on full-length radiographs showing increased stress in the involved knee compartment.
* Presence of associated ipsilateral ankle joint problem.

Primary outcomes:
measure: Lysholm knee score
timeFrame: baseline, 2 years postoperative
measure: Knee Injury and Osteoarthritis and Outcome (KOOS) score
timeFrame: baseline, and 2 years postoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Faculty of Medicine, Cairo University
state: Cairo
Study officials:
affiliation: Cairo University
name: mohamed H khalil, M.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ronnblad E, Rotzius P, Eriksson K. Autologous semitendinosus tendon graft could function as a meniscal transplant. Knee Surg Sports Traumatol Arthrosc. 2022 May;30(5):1520-1526. doi: 10.1007/s00167-021-06606-8. Epub 2021 Jun 8.
citation: Kohn D. Autograft meniscus replacement: experimental and clinical results. Knee Surg Sports Traumatol Arthrosc. 1993;1(2):123-5. doi: 10.1007/BF01565466.
citation: Johnson LL, Feagin JA Jr. Autogenous tendon graft substitution for absent knee joint meniscus: a pilot study. Arthroscopy. 2000 Mar;16(2):191-6. doi: 10.1016/s0749-8063(00)90035-5.
citation: Milenin O, Strafun S, Sergienko R, Baranov K. Lateral Meniscus Replacement Using Peroneus Longus Tendon Autograft. Arthrosc Tech. 2020 Jul 22;9(8):e1163-e1169. doi: 10.1016/j.eats.2020.04.016. eCollection 2020 Aug.