Clinical trial NCT05413590: Description of Physical Activity Effect on Neuromuscular Fatigue of Older People
Official title: Description of Physical Activity Effect on Neuromuscular Fatigue of Older People
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Aging
Fatigue
Keywords: cardiovascular function
neuromuscular function
V02max
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2022-06-10
Enrollment: 93
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: There is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance with advancing age. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. The aim of this project is to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.

Detailed description: With advancing age, there is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance and increases the likelihood that older people will lose their independence. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. Indeed, recent data support the idea that it is fitness level, not age that explains physiological responses to exercise. However, although there are data about how quickly cardiovascular and neuromuscular functions decline throughout life, less is known on the extent physical activity can help mitigate the loss of these functions. The aim of this project is therefore to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.

Eligibility criteria: Inclusion Criteria:

* Aged 18 to 35 for the young group, between 65 and 80 for the old group and over 80 for the very old group.
* Signed consent for the study obtained
* Subject affiliated or entitled to a social security scheme

Exclusion Criteria:

* Pathology or surgical intervention causing a locomotor disorder
* Neurological, cardiovascular or psychological pathology
* Participants will be excluded if resting or exercise ECG responses show any abnormality, or if resting Heart Rate (HR) \> 100 bmp, resting blood pressure \> 144 (systolic) / 95 (diastolic) mmHg, pulmonary and or cardiac disease that could affect the health of the participant (arrhythmias and stroke)
* Mini-Mental State Examination score \< 20 (\>80 years old)
* Significant change in the amount of physical practice over the last 5 years.

Primary outcomes:
measure: Maximal voluntary contraction (MVC) of the knee extensor muscle measurement
timeFrame: At 48 hours
Secondary outcomes:
measure: Voluntary activation measurement (%)
timeFrame: At 48 hours
measure: Maximal voluntary contraction (MVC) of the plantar flexor muscle measurement
timeFrame: At 48 hours
measure: Maximal voluntary contraction (MVC) of the hand grip measurement
timeFrame: At 48 hours
measure: Cardiac variability(ms)
timeFrame: At 48 hours
measure: Muscle oxygenation (%)
timeFrame: At 48 hours
measure: Balance test (s)
timeFrame: At 48 hours
measure: Test of Get-up-and-Go (s)
timeFrame: At 48 hours
measure: Reaction force on the ground for each step (N)
timeFrame: At 72 hours
measure: Maximal oxygen consumption (VO2max) during an effort test on a cycloergometer
timeFrame: At 72 hours
measure: Functional Assessment of Chronic Illness Therapy (FACIT) questionnaire
timeFrame: At inclusion
measure: Quality of life via the SF-36 questionnaire
timeFrame: At inclusion
Other outcomes:
Locations:
city: Saint-Étienne
country: France
facility: Chu de Saint-Etienne
Study officials:
affiliation: Centre Hospitalier Universitaire de Saint Etienne
name: LEONARD FEASSON, PHD
role: PRINCIPAL_INVESTIGATOR
affiliation: UNIVERSITE DE SAINT ETIENNE
name: Guillaume MILLET, PhD
role: STUDY_CHAIR
References: