Clinical trial NCT04921202: Metabolic Syndrome and Degenerative Meniscus Lesions Related Knee Function
Official title: First Affiliated Hospital of Jinzhou Medical Universtiy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Metabolic Syndrome
Meniscus Lesion
Obesity, Abdominal
Knee Arthritis
Keywords: Metabolic Syndrome
degenerate meniscus lesions
obesity
knee function
Lead sponsor: The First People's Hospital of Jingzhou
Sponsor class: OTHER
First posted: 2021-06-10
Enrollment: 180
Sex: ALL
Minimum age (years): 35
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: participants from Jinzhou City, west of Liaoning Province

Brief summary: Studies have suggested that Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis. However, no studies demonstrate the relationship between obese patients with metabolic syndrome and degenerate meniscus lesions and its knee function.The aim is to detect the correlation between obese patients with metabolic syndrome and degenerate meniscus injuries.

Detailed description: Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis. However, no studies demonstrate the relationship between patients with metabolic syndrome and degenerate meniscus lesions or knee function. Participants were recruited from First Affiliated Hospital of Jinzhou Medical University. 100 BMI\<24 people without Metabolic syndrome volunteers aged between 35-70 years old and 80 Metabolic syndrome patients with BMI\>27 were included in the study. Obese patients with MetS were assessed knee function and degenerate meniscus tears verified by magnetic resonance imaging. And patients with a mild or no osteoarthritis with Kellgren and Lawrence grade\<2 verified by X ray. We tested the relationship between metabolic syndrome and degenerate meniscus lesions. Obese patients with MetS and volunteers were detected by Mcmurry's test and MRI image to measure degeneration grade of meniscus tears. Number of MetS components were accounted and the knee function KOOS, IKDC score or degenerate meniscus tears were analyzed.

Eligibility criteria: Inclusion Criteria:

* Must be age between 35 and 70 years old;
* Clinical diagnosis of metabolic syndrome;
* BMI score more than 27 or less than 24
* Clinical diagnosis of 3 grade degneration meniscus leisons;

Exclusion Criteria:

* Must be able to have no acute knee injury such as car crash or acute sports injury;
* Must be able to have no knee surgeries history;
* Must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity;
* Must be able to have no contraindications to MRI;
* Must be able to have no severe cardiopulmonary disease;
* Must be able to have no musculoskeletal or neuromuscular impairments ;
* Must be able to have good visual, hearing, or cognitive;

Primary outcomes:
measure: the Knee injury and Osteoarthritis Outcome Score (KOOS) total
timeFrame: up to 12 month
measure: The International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) score
timeFrame: up to 12 month
Secondary outcomes:
measure: KOOS Pain subscale
timeFrame: up to 12 month
measure: Symptoms subscale
timeFrame: up to 12 month
measure: Activities of Daily Living subscale
timeFrame: up to 12 month
measure: Sport and Recreation function subscale
timeFrame: up to 12 month
measure: knee-related Quality of Life subscale
timeFrame: up to 12 month
measure: KOOS4
timeFrame: up to 12 month
Other outcomes:
Locations:
city: Jinzhou
country: China
facility: First Affiliated Hospital of Jinzhou Medical University
state: Liaoning
Study officials:
affiliation: The First People's Hospital of Jingzhou
name: Hongyu Wang, Doctor
role: PRINCIPAL_INVESTIGATOR
References: