louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06166303: Number of Previous Cesarean Sections on the Results of Angiogenic Factors.
Official title: Effect of Number of Previous Cesarean Sections on the Results of Angiogenic Factors. A Descriptive, Prospective Study.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Cesarean Section
Keywords: Cesarean section
Angiogenic factors
Preeclampsia
Lead sponsor: Saint Thomas Hospital, Panama
Sponsor class: OTHER
First posted: 2023-12-12
Enrollment: 540
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Pregnant woman with a previous cesarean section

Brief summary: Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit.

Although the usefulness of angiogenic factors in these scenarios is known, little is known about the effects that other conditions might have on their serum levels, mainly those that have an effect on trophoblastic invasion, the process that initiates implantation of the pregnancy in the endometrium. The purpose of the present study is to assess the effect that a history of uterine surgery, such as caesarean section, might have on angiogenic factor scores in subjects with no history of a hypertensive disorder of pregnancy.


Eligibility criteria: Inclusion Criteria:

* 36 weeks of gestation or more
* Singleton pregnancy
* Previous cesarean section (case)

Exclusion Criteria:

* Vasculitis
* Twin pregnancy
* Chronic endometritis
* Smoking
* Lupus
* Renal failure
* Liver disease
* Thrombocytopenia

Primary outcomes:
measure: Index sFlt-1/PIGF
timeFrame: From the moment of randomization up until delivery. Between 24-48 hours.
Secondary outcomes:
measure: Progression to preeclampsia
timeFrame: Up until discharge. On average, 7 days
Other outcomes:
Locations:
city: Panama
country: Panama
facility: Saint Thomas H
Study officials:
affiliation: Hospital Santo Tomás
name: Osvaldo Reyes
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02622503: A Study on Rheumatoid Arthritis Patients Treated With Rituximab
Official title: Retrospective Data Collection on Rheumatoid Arthritis (RA) Patients Treated With Rituximab in Finland.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rheumatoid Arthritis
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2015-12-04
Enrollment: 81
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Rheumatoid arthritis (RA) patients treated with rituximab in Finland.

Brief summary: The purpose of the study is to obtain an overall picture of rituximab treatments and treatment responses in RA patients.


Eligibility criteria: Inclusion Criteria:

* Rheumatoid arthritis (RA) patients treated with rituximab in Finland

Exclusion Criteria:

* Not applicable

Primary outcomes:
measure: Information on previous RA treatments
timeFrame: 3 months
measure: Information on rituximab treatment responses
timeFrame: 3 months
measure: Information on concomitant medications
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Helsinki
country: Finland
city: Jyväskylä
country: Finland
city: Lahti
country: Finland
city: Tampere
country: Finland
city: Turku
country: Finland
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References:
Clinical trial NCT05309603: Alterations in Gait, Strength, and Power After Ruck Marching
Official title: Alterations in Gait, Strength, and Power After Ruck Marching
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Fatigue
Lead sponsor: State University of New York at Buffalo
Sponsor class: OTHER
First posted: 2022-04-04
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: The purpose of this study is to determine change in injury risk and performance variables in males and females after walking unloaded and carrying a load with two different distributions (high-pack placement and mid-pack placement) to identify differences in injury risk


Eligibility criteria: Inclusion Criteria:

* Healthy, physically active individuals
* 18-39 years old

Exclusion Criteria:

* History of musculoskeletal injury within the last six months or still under a physicians care for an injury occurring more than six month prior
* History of spinal disc injury
* History of cardiovascular, metabolic, respiratory, neural, or renal disease
* No previous history or education of completing resistance exercise
* Hypertensive or tachycardic during the screening visit (SBP \> 139 mmHg, DBP \> 89 mmHg, heart rate \> 100 bpm)
* Taking medication or supplements with a known side effect of affecting physiologic responses to exercise (e.g., beta blockers, omega-3 fatty acids, statins, aspirin)
* Any form of tobacco or nicotine use
* A positive pregnancy test at any point in the study
* Study physician discretion based on any other medical condition or medication
* Gastrointestinal disease or previous surgery prohibiting internal body temperature pill use. Subjects who have any contraindication to internal body temperature pill ingestion will be given the option to insert the pill rectally (as a suppository) or use a rectal probe.

Primary outcomes:
measure: Change in Oxygen Consumption
timeFrame: Upon completion of 3 miles of walking, an average of 45 minutes
measure: Increased muscular jerk
timeFrame: Upon completion of 3 miles of walking, an average of 45 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Buffalo
country: United States
facility: University at Buffalo
state: New York
Study officials:
affiliation: University at Buffalo
name: Riana Pryor, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03839303: Comparison Between Mini Implant Supported Appliance and Headgear in Treatment of Maxillary Excess in Growing Patients
Official title: Infra-zygomatic Mini Implant Supported Appliance for Distalization and Intrusion of Maxillary Dentition Compared to Headgear in Growing Patients: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Class II Division 1 Malocclusion
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2019-02-15
Enrollment: 26
Sex: MALE
Minimum age (years): 7
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to compare an Infra-zygomatic Mini implant supported appliance with headgear in distalization and intrusion of maxillary dentition for treatment of growing patients with class II malocclusion (maxillary excess)

Detailed description: In this randomized trial, 2 groups will be included. The first group will receive an Infra-zygomatic Mini implant supported appliance. In the second group, the patient will receive a removable high pull headgear. the follow-up period will be 8 months or till class I canine or incisors relation is obtained. the assessment will be through a lateral cephalogram

Eligibility criteria: Inclusion Criteria:

1. Growing patients ( cervical vertebrae maturation stage cs2-cs3 )
2. Maxillary excess
3. Minimum overjet 4 mm
4. class II canines or incisors
5. Increased incisal show at rest and on smiling
6. Normal and increased vertical growth pattern
7. No previous orthodontic treatment
8. No congenitally messing teeth except third molars

Exclusion Criteria:

1. Inadequate incisal show
2. Class II with deficient mandible and normal maxilla
3. Patients with any syndrome
4. Patients with horizontal growth pattern

Primary outcomes:
measure: Anteroposterior position changes of upper first molars.
timeFrame: 8 months
measure: Anteroposterior position changes of the maxilla
timeFrame: 8 months
Secondary outcomes:
measure: Vertical position changes in maxilla
timeFrame: 8 months
measure: Vertical position changes of upper first molars
timeFrame: 8 months
measure: Position changes of upper incisors
timeFrame: 8 months
measure: Anteroposterior skeletal changes in mandible
timeFrame: 8 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
Study officials:
affiliation: Cairo University
name: Ahmed Afifi
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03438903: Comparison of Repeatability Between SS and SD-OCT for Measuring Retinal Thickness in Various Retinal Diseases
Official title: Comparison of Repeatability Between Swept-source and Spectral-domain Optical Coherence Tomography for Measuring Inner Retinal Thickness in Various Retinal Diseases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Macula Abnormality
Lead sponsor: Hanyang University
Sponsor class: OTHER
First posted: 2018-02-20
Enrollment: 114
Sex: ALL
Minimum age (years): 19
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: normal control : 36 eyes of 36 subjects

retinal disease group: 78 eyes of 78 patients

Brief summary: Comparison of intradevice repeatability of thickness measurements for macular area in the eyes with normal and various retinal diseases using SS-OCT and SD-OCT

Detailed description: The investigators studied the intradevice repeatability of thickness measurements for total retina, retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform (GC-IPL) layers of macular area in the eyes with normal and various retinal diseases using SS-OCT and SD-OCT and compared the repeatability between two devices.

Eligibility criteria: Inclusion Criteria:

* Age-matched normal group was composed of subjects with age over at least 19 years,
* a best-corrected visual acuity of 20/25 or higher,
* normal fundus and intraocular pressure (IOP) \< 21mm Hg.

Exclusion Criteria:

* an spherical equivalent (SE) larger than ± 6 D,
* cataract graded as more severe than grade 3 (Lens Opacities Classification System III),
* a history of glaucoma and optic nerve diseases, or a history of vitrectomy.

Primary outcomes:
measure: To compare repeatability between swept-source optical coherence tomography (SS-OCT) and spectral-domain OCT (SD-OCT) devices for the measurement of retinal thickness in various retinal diseases.
timeFrame: Each device was examined twice consecutively within one minutes. After one OCT device exam, another OCT exam was performed immediately. The interval between test devices did not exceed 5 minutes.
Secondary outcomes:
measure: To compare repeatability according to the degree of macular thickness
timeFrame: Each device was examined twice consecutively within one minutes. After one OCT device exam, another OCT exam was performed immediately. The interval between test devices did not exceed 5 minutes.
Other outcomes:
Locations:
city: Guri-si,
country: Korea, Republic of
facility: Hanyang University Guri Hospital
state: Gyeonggi-do
Study officials:
affiliation: Hanyang University
name: Mincheol Seong, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT03773003: Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME)
Official title: Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME) by Lipidomics, Metabolomics, Microbiome and Exome Analysis and Investigation of Clinical Improvement Under Administration of Probiotics
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cancer Related Fatigue
Fatigue Syndrome, Chronic
Keywords: Cancer Fatigue, Chronic Fatigue
Lead sponsor: Universität des Saarlandes
Sponsor class: OTHER
First posted: 2018-12-12
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Double blinded, placebo controlled intervention with probiotics

There are three groups in the study:

1. Tumor disease with fatigue
2. Tumor disease without fatigue
3. Healthy control group
Primary purpose: BASIC_SCIENCE

Brief summary: Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue Syndrome (CFS/ME) by Lipidomics, Metabolomics, Intestinal and Peritoneal Microbiome Analysis and Exome Analysis and Investigation of a Possible Benefit of Probiotics.

Detailed description: This study aims to identify the underlying pathophysiology of Cancer Related Fatigue (CRF) by screening lipidome, metabolome, exome and microbiome of affected patients with tumor disease with and without fatigue. These results will be compared to an age- and gender matched control group with a comparable tumor disease and to another age- and gender matched control group without tumor disease.

The investigators are following the same strategy for investigating an underlying pathophysiology of Chronic Fatigue Syndrome (CFS/ME) in another group of patients. The age- and gender matched control group will be established from the beforementioned control group.

The investigators will also be screening for a peritoneal microbiome (possible correlate for leaky gut) in study patients undergoing abdominal surgery.

We will also investigate changes in fatigue and in lipidome, metabolome, exome and microbiome by double-blinded, placebo-controlled administration of probiotics to the study population.

Eligibility criteria: Inclusion Criteria:

* histologically, cytologically or radiologically confirmed tumor disease
* indication for chemotherapy
* Written consent to participation

Exclusion Criteria:

* chronic-inflammatory bowel disease
* pregnancy

Primary outcomes:
measure: Improvement of fatigue symptoms
timeFrame: 3 months after end of chemotherapy
Secondary outcomes:
Other outcomes:
Locations:
city: Homburg
country: Germany
facility: Saarland University Medical Center
state: Saarland
Study officials:
affiliation: University Hospital, Saarland
name: Michael Jelden, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01059890: Cerebral Antibiotics Distribution After Acute Brain Injury
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Bacterial Infection
Brain Injury
Lead sponsor: Poitiers University Hospital
Sponsor class: OTHER
First posted: 2010-02-01
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: The aim of the study is to explore the distribution of antibiotics in the brain after an acute brain injury because brain infections treatment is still an health care problem.


Eligibility criteria: Inclusion Criteria:

* Acute brain injury
* Patient who receive an antibiotic for an infection or prophylaxy
* Glasgow coma score \< 8

Exclusion Criteria:

* Age \< 18 years old
* Pregnant woman
* HCV, HIV, HBV infection

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Poitiers
country: France
facility: Poitiers University Hospital - 2 rue de la Milétrie - Réanimation chirugicale
Study officials:
References:
Clinical trial NCT04196790: Development of a Model to Predict the Risk of Venous Thromboembolic Events in Patients With Metastatic Bronchopulmonary Cancer
Official title: Développement d'un modèle prédictif du Risque de Survenue d'évènements Thromboemboliques Veineux Chez Les Patients Atteints de Cancer Broncho-pulmonaire métastatique
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Metastatic Bronchopulmonary Cancer
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2019-12-12
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 500 metastatic cancer patients prospectively recruited in this prospective cohort.

Brief summary: Venous thrombo-embolism (VTE) is a frequent and serious complication of cancer. However, predictive tools for VTE in cancer patients is lacking.

In patients with metastatic broncho-pulmonarycancer, biochemical characteristics might help to identify patients at high risk for VTE.

The aim of this study is to derive a predictive score combining clinical and biochemical variable that predict VTE in metastatic broncho-pulmonary cancer.

Detailed description: Venous thrombo-embolism (VTE) is a frequent and serious complication of cancer. However, predictive tools for VTE in cancer patients is lacking.

In patients with metastatic broncho-pulmonarycancer, biochemical characteristics might help to identify patients at high risk for VTE, particularly in adenocarcinoma.

The aim of this study is to derive a predictive score combining clinical and biochemical variable that predict VTE in metastatic broncho-pulmonary cancer.

Eligibility criteria: Inclusion Criteria:

* metastatic broncho-pulmonary cancer
* age ≥18 years
* who are eligible for chemotherapy
* non opposition obtained

Exclusion Criteria:

* age \<18 years
* pregnancy, breast feeding
* VTE in the past 6 months or at the time of cancer diagnosis
* surgery in the past 3 months
* refusal to participate

Primary outcomes:
measure: venous thromboembolism at 12 months
timeFrame: 12 months
Secondary outcomes:
measure: overall survival
timeFrame: one year
measure: survival without progression
timeFrame: one year
measure: VTE at 6 months
timeFrame: 6 months
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU de Brest
city: Morlaix
country: France
facility: CH des Pays de Morlaix
city: Quimper
country: France
facility: CHIC de QUIMPER
Study officials:
References:
Clinical trial NCT02799290: Adipose Tissue Extract and Platelet-rich Plasma Use for Wound Healing
Official title: The Effect of Adipose Tissue Extract and Platelet-rich Plasma on Split-thickness Donor Site Wound Healing. A Comparative Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Wound Healing Disturbance of
Lead sponsor: Tampere University
Sponsor class: OTHER
First posted: 2016-06-14
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Adipose Tissue Extract (ATE) has been found to be an autologous source of growth factors with proven in vitro angiogenic and adipogenic properties.It is obtained by a simple lipoaspirate procedure. We sought to compare the effect of ATE with another known source, platelet-rich plasma to compare the wound healing characteristics on skin graft donor sites.

Detailed description: The investigators enrolled 24 participants with an indication for skin graft. Two or more split-thickness grafts are harvested per patient, one serving as control and the other as experimental. The experimental sites were covered with either autologous PRP gel or ATE prepared in the OR, which was selected in an unblinded manner due to surgical theater convenience. However, donor sites were randomized through a computer generator. Covered with a semiocclusive film, wounds were separated and followed up on days 3,5,7,10,14 for wound healing and 30 and 60 for scar evaluation. Digital photography and specto-photocutometry was employed to know the hemoglobin and melanin content of the wounds, and custom-made software was used to calculate the percentage of wound re-epithelialization.

Eligibility criteria: Inclusion Criteria:

* donor site indication

Exclusion Criteria:

* immunosupressive states
* terminal renal insufficiency
* pregnancy
* coagulation dyscrasias
* active infection in donor site

Primary outcomes:
measure: Wound Re-epithelization
timeFrame: 30 days
Secondary outcomes:
measure: Scar Properties
timeFrame: 30 and 60 days
measure: Oxygenated Hemoglobin
timeFrame: day 30 and 60
measure: Melanin Concentration in Wound
timeFrame: day 30 and 60
Other outcomes:
Locations:
city: Tampere
country: Finland
facility: Jenny Lopez, Ilkka Kaartinen
state: Pirkanmaa
Study officials:
affiliation: Tampere University
name: Timo Ylikomi, PhD
role: STUDY_DIRECTOR
References:
citation: Sarkanen JR, Kaila V, Mannerstrom B, Raty S, Kuokkanen H, Miettinen S, Ylikomi T. Human adipose tissue extract induces angiogenesis and adipogenesis in vitro. Tissue Eng Part A. 2012 Jan;18(1-2):17-25. doi: 10.1089/ten.TEA.2010.0712. Epub 2011 Oct 4.
citation: Sarkanen JR, Ruusuvuori P, Kuokkanen H, Paavonen T, Ylikomi T. Bioactive acellular implant induces angiogenesis and adipogenesis and sustained soft tissue restoration in vivo. Tissue Eng Part A. 2012 Dec;18(23-24):2568-80. doi: 10.1089/ten.TEA.2011.0724. Epub 2012 Aug 17.
Clinical trial NCT00426790: Open Lung Approach During General Anaesthesia to Prevent Post-Operative Pulmonary Complications
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Postoperative Complications
Lead sponsor: Università degli Studi dell'Insubria
Sponsor class: OTHER
First posted: 2007-01-25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The hypothesis of this study is that the "Open lung approach" ( recruitment and PEEP) during general anaesthesia reduces atelectasis formation and improves respiratory function in the immediate post-operative period after major abdominal surgery.

This is a prospective, randomized, controlled clinical-trial,performed in patients undergoing major abdominal surgery, to compare the effects on the post-operative pulmonary complications of two different intraoperative ventilatory strategies during general anaesthesia: 1- Control Group: PEEP 0 cmH2O without recruitment manoeuvre; 2- Treatment Group:recruitment manoeuvre (after intubation and before extubation) and PEEP 10 cmH2O In the post-operative period the following variables will be recorded at the first, third and fifth postoperative day: 1- Gas-exchange in air; 2- Chest X-ray for atelectasis evaluation; 3- signs of pulmonary complication (cough, secretions, dyspnea, thoracic pain)


Eligibility criteria: Inclusion Criteria:

* Patients with ASA 1, 2 and 3
* Age higher than 18 years
* Major abdominal surgery
* General anesthesia

Exclusion Criteria:

* COPD with FEV1 lower than 50%
* Ischemic cardiopathy
* Loco-regional anesthesia alone
* Minor abdominal surgery
* Laparoscopic surgery

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Varese
country: Italy
facility: Ospedale di Circolo e Fondazione Macchi
Study officials:
affiliation: University of Insubria, Varese, Italy
name: Paolo Pelosi, Professor
role: PRINCIPAL_INVESTIGATOR
References: