Clinical trial NCT06544538: Acute Kidney Injury After Cardiac Arrest
Official title: Causes and Clinical Outcomes of Acute Kidney Injury After Cardiac Arrest: A Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Kidney Injury
Keywords: cardiac arrest
Acute kidney injury
Mortality
Lead sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Sponsor class: OTHER_GOV
First posted: 2024-08-09
Enrollment: 82
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients admitted to the Anesthesiology and Reanimation intensive care unit of Bakırköy Dr. Sadi Konuk Training and Research Hospital after cardiac arrest

Brief summary: The development of AKI (Acute Kidney Injury) after cardiac arrest is a common factor associated with mortality. In this study, we aimed to evaluate the factors that increase the risk of developing AKI after cardiac arrest.

For the study, patients were evaluated for the incidence of acute kidney injury (AKI), factors that increase the risk of AKI, and the impact of AKI on mortality. In this process, demographic data, comorbidities, hemodynamic data, laboratory data, clinical symptoms and findings recorded in the electronic decision support system were recorded and analyzed.

Detailed description: This retrospective study was performed on patients hospitalized in intensive care units after cardiac arrest between 2013 and 2022. Patients who met the inclusion criteria were included in the study. Urea, creatinine values, and whether AKI was diagnosed or not were obtained from the data registry system. Statistical evaluation was performed using univariate binary logistic regression analysis.

Demographic data, location of cardiac arrest (in-hospital, out-of-hospital), and duration of CPR were recorded. In addition, the causes of cardiac arrest, HR/MAP (heart rate/average arterial pressure) ratio, and whether VSP (vasopressor) or INO (inotropic) medication was needed were recorded.

Eligibility criteria: Inclusion Criteria:

* adult patients with spontaneous circulation after cardiac arrest and admitted to the intensive care unit

Exclusion Criteria:

* Deaths in the first 48 hours
* Missing data
* End stage CKD or first day hemadsorption
* CPR time \<3 min
* Unwitnessed cardiac arrest
* Terminal malignancy

  * 90 years old
* Having a pace marker
* Massive bleeding
* ECMO application
* First day diyabetes insipitus

Primary outcomes:
measure: Acute Kidney Injury (AKI)
timeFrame: Within 48 hours after intensive care unit admission
Secondary outcomes:
measure: AKI incidence
timeFrame: Within 48 hours after intensive care unit admission
measure: Mortality
timeFrame: Clinical and laboratory data within 48 hours after intensive care unit admission will be used
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Bakırköy Dr. Sadi Konuk Training and Research Hospital
Study officials:
affiliation: Istanbul Bakırköy Dr Sadi Konuk Training and Research Hospital
name: MURAT ASLAN, Dr
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Patyna S, Riekert K, Buettner S, Wagner A, Volk J, Weiler H, Erath-Honold JW, Geiger H, Fichtlscherer S, Honold J. Acute kidney injury after in-hospital cardiac arrest in a predominant internal medicine and cardiology patient population: incidence, risk factors, and impact on survival. Ren Fail. 2021 Dec;43(1):1163-1169. doi: 10.1080/0886022X.2021.1956538.