Clinical trial NCT05919979: Effect of a Physical Exercise Session Performed During a 24-34 Hour Fasting Period on Energy Metabolism and Cognitive Function in Healthy Adults
Official title: Efecto De Una Sesión De Ejercicio Físico Realizada Durante Un Periodo De Ayuno De 24-34 Horas Sobre El Metabolismo Energético Y La Función Cognitiva En Adultos Sanos: Estudio Piloto
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Energy Metabolism
Lead sponsor: Universidad de Granada
Sponsor class: OTHER
First posted: 2023-06-27
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study explores the impact of high-intensity exercise during fasting on energy metabolism and cognitive function in healthy adults. Changes in respiratory exchange ratio, blood substances, and cognitive performance will be measured after 24 and 34 hours of fasting with and without exercise in a randomized crossover design.


Eligibility criteria: Inclusion Criteria:

* 18-40 years old.
* Body mass index: 18.5-30.0 Kg/m2.
* Stable body weight (5kg range within the last 3 months)
* Being able to consume all the food items provided as part of the study.
* Not having change the time zone or have shifted sleeping hours equivalent to more than 3 hours on the previous 2 weeks.

Exclusion Criteria:

* Diagnosed with any chronic condition that, in the research team's opinion or based on the American College of Sports Medicine guidelines, could contraindicate the implementation of 34-hour fasting periods and/or high-intensity exercise.
* Diagnosed with a chronic endocrine, digestive, rheumatic, neurological, cardiac, pulmonary, autoimmune, or infectious condition that affects energy metabolism.
* Presenting any signs or symptoms of illness that, in the research team's opinion or based on the American College of Sports Medicine guidelines, could contraindicate the implementation of 34-hour fasting periods and/or high-intensity exercise.
* Pregnant or breastfeeding.
* Using medications or supplements that may alter energy metabolism.
* Currently undergoing or having undergone any type of nutritional intervention or treatment in the past 3 months.
* Engaging in more than 5 hours per week of habitual moderate-to-vigorous cycling.
* Any other condition that, in the research team's opinion, discourages participation in the study.

Primary outcomes:
measure: Respiratory Exchange Ratio
timeFrame: 24-hour after starting the fasting period
Secondary outcomes:
measure: Respiratory Exchange Ratio
timeFrame: 34-hour after starting the fasting period
measure: Serum insulin concentration
timeFrame: 24-hour after starting the fasting period
measure: Serum insulin concentration
timeFrame: 34-hour after starting the fasting period
measure: Serum glucose concentration
timeFrame: 24-hour after starting the fasting period
measure: Serum glucose concentration
timeFrame: 34-hour after starting the fasting period
measure: Dimensional Change Card Sort Test (NIH toolbox)
timeFrame: 24-hour after starting the fasting period
measure: Dimensional Change Card Sort Test (NIH toolbox)
timeFrame: 34-hour after starting the fasting period
measure: List Sorting Working Memory Test (NIH toolbox)
timeFrame: 24-hour after starting the fasting period
measure: List Sorting Working Memory Test (NIH toolbox)
timeFrame: 34-hour after starting the fasting period
measure: Flanker Test (NIH toolbox)
timeFrame: 24-hour after starting the fasting period
measure: Flanker Test (NIH toolbox)
timeFrame: 34-hour after starting the fasting period
Other outcomes:
Locations:
city: Granada
country: Spain
facility: Instiuto Mixto Universitario Deporte y Salud
Study officials:
References: