Clinical trial NCT01553812: The Assessment of Airway Resistance and Airtrapping in Elderly COPD Patients by Forced Oscillation Technique (FOT)
Official title: The Assessment of Airway Resistance and Airtrapping in Elderly COPD Patients by Forced Oscillation Technique (FOT)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COPD
Keywords: forced oscillation technique
COPD
elderly
airway resistance
airtrapping
Lead sponsor: Kwong Wah Hospital
Sponsor class: OTHER
First posted: 2012-03-14
Enrollment: 158
Sex: ALL
Minimum age (years): 60
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: COPD patients from both 'in-patient' and 'outpatient clinic' in Kwong Wah Hospital, Hong Kong, China

Brief summary: The study hypothesize that parameters of new function machine---'forced oscillation technique' (FOT) can correlate well with the conventional lung function data for measurement of airway resistance and airtrapping in elderly COPD patients.

Detailed description: INTRODUCTION:

Forced oscillation technique (FOT) may be a good supplementary tool to assess lung function in elderly since it is a simple and fast tool requiring minimal patients' cooperation.

AIMS:

To investigate the accuracy of forced oscillation test FOT in assessment of airway resistance and airtrapping in elderly COPD patients by comparing FOT parameters to various conventional lung function parameters including FEV1, FEF 25-75, RV/TLC ratio, IC etc. The best FOT parameter for airway resistance and airtrapping is also determined.

STUDY DESIGN:

A cross-sectional study conducted in Kwong Wah Hospital, Hong Kong, SAR

METHODS:

COPD patients were recruited from 1st Jan, 2010 to 31st Dec 2011. Both of the lung function tests (forced oscillation technique (FOT) and conventional lung function test) were performed. Parameters of FOT (FRes FDep, RAvr, XAvr, were compared with conventional lung function test for assessment of both airway resistance and airtrapping in COPD subjects. Adjusted FOT parameters (FResRatio and FDep) were also compared with %FEV1 and different GOLD stages.

Statistics:

Comparison between FOT parameters and spirometric parameters was done by correlation test and expressed as Spearman coefficient. ANOVA test is used to compare FOT parameters among different groups of GOLD stages (stage 1 to 4) and groups with various degree of airtrapping (stage 1 to 3). Post hoc analysis was estimated by Bonferroni test.

Eligibility criteria: Inclusion Criteria:

* COPD patients with previous lung function tests confirming irreversible obstructive pattern

Exclusion Criteria:

* Lung function test failed to show any obstructive pattern
* Paitents with co-existing pulmonary diseases including asthma, interstitial lung diseases, lung malignancy etc.
* Patients with active infectious diseases like tuberculosis

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Tse HN, Tseng CZ, Wong KY, Yee KS, Ng LY. Accuracy of forced oscillation technique to assess lung function in geriatric COPD population. Int J Chron Obstruct Pulmon Dis. 2016 May 26;11:1105-18. doi: 10.2147/COPD.S102222. eCollection 2016.