Clinical trial NCT02942784: A Comparison of Three Nutritional Assessment Methods Predicting Prognosis in COPD With Respiratory Failure
Official title: Prediction of Prognosis in Patients With Chronic Obstructive Pulmonary Disease With Respiratory Failure: A Comparison of Three Nutritional Assessment Methods
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Respiratory Insufficiency
Lead sponsor: West China Hospital
Sponsor class: OTHER
First posted: 2016-10-24
Enrollment: 750
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed with chronic obstructive pulmonary disease with respiratory failure during January 2014 to March 2016 at West China Hospital by review of medical records.

Brief summary: This is a retrospective study of patients diagnosed with chronic obstructive pulmonary disease (COPD) with respiratory failure and admitted in West China Hospital during January 2014 to March 2016 by review of medical records. The following variables will be retrospectively studied: age, sex, marriage, height, weight, respiratory rate, PaO2, PaCO2, nutritional risk screening 2002 (NRS 2002) score, ALB, short-term and long-term prognostic outcomes, and so on. The purpose of this study is to compare the predictive power of three widely used nutritional assessment methods (BMI, NRS 2002 and ALB) predicting the prognostic outcomes in a cohort of COPD patients with respiratory failure.


Eligibility criteria: Inclusion Criteria:

* Newly diagnosis of COPD at West China Hospital during January 2014 to March 2016
* Partial pressure of O2 (PaO2) \< 60 mmHg and/or partial pressure of CO2 (PaCO2) \>50 mmHg
* Age ≥ 18 years
* Respiratory rates \> 23 bpm

Exclusion Criteria:

* Pregnancy or during lactation
* Ventilatory dysfunction due to neuromuscular disorders, acute and chronic thromboembolic disease, severe illness in other systems
* Incomplete medical profiles

Primary outcomes:
measure: Predictive value of nutritional assessment methods in identifying COPD patients with respiratory failure who will have poor prognosis, in terms of in-hospital death
timeFrame: up to 27 months
measure: Predictive value of nutritional assessment methods in identifying COPD patients with respiratory failure who will have poor prognosis, in terms of 1-year death after discharge
timeFrame: up to 27 months
measure: Predictive value of nutritional assessment methods in identifying COPD patients with respiratory failure who will have poor prognosis, in terms of 30-day readmission after discharge
timeFrame: up to 27 months
Secondary outcomes:
measure: Collection of Demographics (age, sex, marriage)
timeFrame: up to 27 months
measure: Number of participants with in-hospital death
timeFrame: up to 27 months
measure: Number of participants with 1-year death after discharge
timeFrame: up to 27 months
measure: Number of participants with 30-day readmission after discharge
timeFrame: up to 27 months
Other outcomes:
Locations:
city: Chengdu
country: China
facility: West China Hospital
state: Sichuan
Study officials:
References: