Clinical trial NCT04645303: Injection of Hyaluronic Acid Versus Corticosteroid for Treatment of Trigger Finger
Official title: Ultrasound-Guided Injection of Hyaluronic Acid Versus Corticosteroid for Treatment of Trigger Finger: Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: Trigger Finger
Keywords: Trigger finger
Hyaluronic Acid
Corticosteroid
Ultrasound-guided injection
Lead sponsor: Dubai Health Authority
Sponsor class: OTHER_GOV
First posted: 2020-11-27
Enrollment: 100
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to compare the therapeutic effects of hyaluronic acid versus steroid injections in treating trigger fingers using ultrasound guidance

Detailed description: A prospective randomized controlled study designed to compare the outcomes of injecting patients with trigger finger with hyaluronic acid versus corticosteroid under ultrasound guidance

Eligibility criteria: Inclusion Criteria:

* Adult (\>18 years)
* Patients with a clinical diagnosis of trigger finger grade 1-3 on the Quinnell grading scale and confirmed diagnosis by ultrasound.

Exclusion Criteria:

* Quinnell's classification grade IV (contracture)
* Prior injection within 6 months
* Prior operation of the affected finger
* Presence of any contracture in the proximal interphalangeal or metacarpophalangeal joint, and
* History of diabetes, hypothyroidism, and
* Rheumatic or connective tissue disease
* Allergy to triamcinolone or hyaluronic acid
* Pregnancy
* Secondary triggering e.g. Trauma, infection
* Trigger finger symptoms duration \>6 months

Primary outcomes:
measure: Change in Quinnell trigger finger grading system:
timeFrame: 1 and 3 months post-injection
Secondary outcomes:
measure: Visual analogue scale (VAS) of pain
timeFrame: 1 and 3 months post-injection
measure: Frequency of tender trigger nodules
timeFrame: 1 and 3 months post-injection
measure: The Quick Disability of the Arm, Shoulder and Hand score
timeFrame: 1 and 3 months post-injection
measure: Changes in Grip strength
timeFrame: 1 and 3 months post-injection
measure: Patient satisfaction with therapy
timeFrame: 1 and 3 months post-injection
measure: Ultrasound evaluation of A1-Pulley
timeFrame: 1 and 3 months post-injection
Other outcomes:
Locations:
city: Dubai
country: United Arab Emirates
facility: Dubai Hospital- Dubai Health Authority
Study officials:
affiliation: Specialist Senior Registrar- Physical Medicine and rehabilitation Department- Dubai hospital
name: Sahar S Khalil, SSR
role: PRINCIPAL_INVESTIGATOR
affiliation: Consultant and Head of Physical Medicine and rehabilitation Department- Dubai hospital
name: Mohamed M Abdulla, Consultant
role: STUDY_CHAIR
References:
citation: Liu DH, Tsai MW, Lin SH, Chou CL, Chiu JW, Chiang CC, Kao CL. Ultrasound-Guided Hyaluronic Acid Injections for Trigger Finger: A Double-Blinded, Randomized Controlled Trial. Arch Phys Med Rehabil. 2015 Dec;96(12):2120-7. doi: 10.1016/j.apmr.2015.08.421. Epub 2015 Sep 1.
citation: Callegari L, Spano E, Bini A, Valli F, Genovese E, Fugazzola C. Ultrasound-guided injection of a corticosteroid and hyaluronic acid: a potential new approach to the treatment of trigger finger. Drugs R D. 2011;11(2):137-45. doi: 10.2165/11591220-000000000-00000.
citation: Abate M, Schiavone C, Salini V. The use of hyaluronic acid after tendon surgery and in tendinopathies. Biomed Res Int. 2014;2014:783632. doi: 10.1155/2014/783632. Epub 2014 May 8.