Clinical trial NCT04605510: Acute Effect of Passive Joint Mobilization in Non-Specific Neck Pain
Official title: Acute Effect of Passive Joint Mobilization on Joint Motion And Pain Perception in Non-Specific Neck Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neck Pain
Keywords: non-specific neck pain
passive joint mobilization
blood markers
neck range of motion
Lead sponsor: Pamukkale University
Sponsor class: OTHER
Collaborators: name: Pamukkale University
First posted: 2020-10-28
Enrollment: 53
Sex: FEMALE
Minimum age (years): 24
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This study includes two groups. Intervention group including women with non-specific neck pain will applied cervical passive joint mobilization and assessment protocol. Control group including healthy women without pain will applied only assessment protocol.
Primary purpose: TREATMENT

Brief summary: Aim of present study is investigating the acute effects of passive joint mobilization on pain perception and range of motion. Study protocol includes passive joint mobilization application to study group with neck pain and blood sample collection of study and healthy control group.

Detailed description: Our purpose of planning this study is to examine the acute effect of passive joint mobilization application on pain perception and range of motion in women with non-specific neck pain.

The hypotheses we will test for this purpose;

H1- Passive joint mobilization application increases the range of motion of the cervical joint in women with non-specific neck pain.

H2- Passive joint mobilization application increases the pressure pain threshold in women with non-specific neck pain.

H3- Passive joint mobilization increases serum Orexin A and Neurotensin levels in women with non-specific neck pain.

Eligibility criteria: Inclusion Criteria:

For Intervention Group;

* Having neck pain lasting more than 30 days and being diagnosed with non-specific neck pain
* Having obtained 14/50 points and above in Neck Disability Index
* Expressing neck pain at least 34/100 points and above on a Visual Analog Scale
* Being 20-45 years old and female

For Healthy Control Group;

- Healthy volunteers without a chronic illness and musculoskeletal pain

Exclusion Criteria:

* Congenital anomalies
* Previously diagnosed orthopedic diseases related to the spine
* Pregnancy and having just given birth
* Within the last 3 months; use of corticosteroids, cytotoxic drugs, or immunosuppressants
* Liver or kidney failure
* Acute or chronic infections (including HIV)
* Serious pathologies (such as cancer, spondylolisthesis, rheumatoid arthritis or ankylosing spondylitis)
* Symptoms of cervical spinal stenosis (such as incoordination of hands, arms and legs, bowel and bladder incontinence)
* Radix compression (such as sensory changes, muscle weakness or decreased reflexes)
* Whiplash or a history of cervical surgery

Primary outcomes:
measure: Cervical Range of Motion
timeFrame: Cervical Range of Motion assessment will take maximum of 5 minutes.
measure: Pain Pressure Threshold
timeFrame: Pain Pressure Threshold assessment will take maximum of 5 minutes.
measure: Neuropeptide Measurement
timeFrame: Blood Sample Collection for Neuropeptide Measurement will take maximum of 5 minutes.
Secondary outcomes:
measure: Pain Intensity Measurement
timeFrame: Pain Intensity Measurement will take maximum of 1 minute.
measure: Neck Disability
timeFrame: Neck Disability measurement will take maximum of 1 minute.
Other outcomes:
Locations:
city: Denizli
country: Turkey
facility: Pamukkale University School of Physical Therapy and Rehabilitation
Study officials:
affiliation: Pamukkale University School of Physical Therapy and Rehabilitation
name: Nesrin YAĞCI, Professor
role: STUDY_DIRECTOR
References:
citation: Plaza-Manzano G, Molina-Ortega F, Lomas-Vega R, Martinez-Amat A, Achalandabaso A, Hita-Contreras F. Changes in biochemical markers of pain perception and stress response after spinal manipulation. J Orthop Sports Phys Ther. 2014 Apr;44(4):231-9. doi: 10.2519/jospt.2014.4996. Epub 2014 Jan 22.
citation: Molina-Ortega F, Lomas-Vega R, Hita-Contreras F, Plaza Manzano G, Achalandabaso A, Ramos-Morcillo AJ, Martinez-Amat A. Immediate effects of spinal manipulation on nitric oxide, substance P and pain perception. Man Ther. 2014 Oct;19(5):411-7. doi: 10.1016/j.math.2014.02.007. Epub 2014 Mar 5.
citation: Lohman EB, Pacheco GR, Gharibvand L, Daher N, Devore K, Bains G, AlAmeri M, Berk LS. The immediate effects of cervical spine manipulation on pain and biochemical markers in females with acute non-specific mechanical neck pain: a randomized clinical trial. J Man Manip Ther. 2019 Sep;27(4):186-196. doi: 10.1080/10669817.2018.1553696. Epub 2018 Dec 11.
citation: Maitland GD. Maitland's Vertebral Manipulation. Seventh Ed. (Hengeveld E, Banks K, eds.). Edinburgh; New York: Churchill Livingstone; 2013. https://www.elsevier.com/books/maitlands-vertebral-manipulation/hengeveld/978-0-7020-4066-5.