Clinical trial NCT01015508: Adipogenic Capacity as a Mediator of Weight Gain
Official title: The Role of the Genetic Background Involved in Weight Regain Through Mechanisms Including Energy Expenditure, Physical Activity and Adipogenic Capacity
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Obesity
Keywords: Weight loss and maintenance
body composition
energy expenditure
adipogenic capacity
physical activity
Lead sponsor: Maastricht University Medical Center
Sponsor class: OTHER
First posted: 2009-11-18
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: To demonstrate differences in response of subjects with a high, low or medium predisposition for weight regain after weight reduction in terms of: body composition; energy expenditure; physical activity; and adipogenic capacity.

Detailed description: The risk for weight regain after weight loss is a major problem for the current obesity treatments, and is largely genetically determined. It is believed that an elucidation of the genetic component in the prognosis of weight management could assist in the development of more effective and individually tailored treatments. However, current research on the genetic component of weight management, and in particular weight regain, is still limited and data available are sometimes inconsistent. The current research proposal aims to identify groups with a high, low or medium predisposition for weight regain, based on a genetic profile and to demonstrate differences in the response of these subjects to a weight maintenance period after weight reduction in terms of body composition, physical activity, adipogenic capacity and energy expenditure.

Eligibility criteria: Inclusion Criteria:

* BMI 28-35
* healthy, no medication
* no smoking
* stable weight (no weight loss/gain \> 5kg in 3 months prior to study)

Exclusion Criteria:

* 28\< BMI \>35
* use of medication
* smoking
* weight loss/gain \> 5kg in 3 months prior to study

Primary outcomes:
measure: Energy expenditure
timeFrame: 0, 2 and 12 months
Secondary outcomes:
measure: Adipogenic capacity, Physical activity and body composition
timeFrame: 0, 2 and 12 months
Other outcomes:
Locations:
city: Maastricht
country: Netherlands
facility: Dept. of Human Biology (Maastricht University)
state: Limburg
Study officials:
affiliation: Maastricht University
name: Klaas R Westerterp, Prof
role: PRINCIPAL_INVESTIGATOR
References:
citation: Camps SG, Verhoef SP, Roumans N, Bouwman FG, Mariman EC, Westerterp KR. Weight loss-induced changes in adipose tissue proteins associated with fatty acid and glucose metabolism correlate with adaptations in energy expenditure. Nutr Metab (Lond). 2015 Oct 24;12:37. doi: 10.1186/s12986-015-0034-1. eCollection 2015.
citation: Camps SG, Verhoef SP, Westerterp KR. Weight loss-induced reduction in physical activity recovers during weight maintenance. Am J Clin Nutr. 2013 Oct;98(4):917-23. doi: 10.3945/ajcn.113.062935. Epub 2013 Aug 28.
citation: Verhoef SP, Camps SG, Gonnissen HK, Westerterp KR, Westerterp-Plantenga MS. Concomitant changes in sleep duration and body weight and body composition during weight loss and 3-mo weight maintenance. Am J Clin Nutr. 2013 Jul;98(1):25-31. doi: 10.3945/ajcn.112.054650. Epub 2013 May 22.
citation: Camps SG, Verhoef SP, Westerterp KR. Weight loss, weight maintenance, and adaptive thermogenesis. Am J Clin Nutr. 2013 May;97(5):990-4. doi: 10.3945/ajcn.112.050310. Epub 2013 Mar 27.
citation: Verhoef SP, Camps SG, Bouwman FG, Mariman EC, Westerterp KR. Physiological response of adipocytes to weight loss and maintenance. PLoS One. 2013;8(3):e58011. doi: 10.1371/journal.pone.0058011. Epub 2013 Mar 7.