Clinical trial NCT04063202: Development of a Predictive Index for Probable Depression Among Secondary School Students
Official title: A Longitudinal Study for Identifying Predictors of Incidence/Remission of Probable Depression and Developing a Predictive Index for Probable Depression Among Secondary School Students
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Depression
Stress
Youth
Keywords: Adolescent
Depression
Stress
Resilience
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2019-08-21
Enrollment: 4799
Sex: ALL
Minimum age (years): 12
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Out of the 18 districts in Hong Kong, nine randomly selected districts will select randomly two schools and while the rest nine will randomly select one school. Replacements of schools will be made upon refusals. Within the selected schools, all Secondary 1-4 students will be invited to join the study. Students will be asked to fill in baseline questionnaires in the absence of teachers in classroom settings.

Brief summary: The present study aims to develop a new predictive index to predict future depression of adolescents by using factors including individual, interpersonal and environmental. The index can be used to predict likelihood of students who are non-probable depression cases convert into probable depression cases. In addition, the investigators also test the factors of depression remission. It can hence be used in school setting to identify high-risk students, and provide them with secondary interventions that are designed by considering modifiable significant variables identified in this unique, large-scale, longitudinal study.

Detailed description: A 12-month longitudinal study will be conducted in secondary school settings.

The investigators will investigate incidence of probable depression (i.e., from non-depression, CESD\<16, at baseline to probable depression, CESD≥16, at month 12) and remission of probable depression.

The investigators will investigate factors that can prospectively predict new cases/remission of probable depression, including both well-documented risk/protective factors and some under-examined but potentially important local factors (e.g. school/academic stress, psychological resilience). The relative importance of the risk/protective factors at different socio-ecological levels will be compared and their combined effect will be identified.

Based on the selected factors, the investigators will derive a new prediction index called the Adolescent Depression Prediction Index (ADPI) in a model building sample and test its performance in predicting incidence of depression in a validation sample among secondary school students in Hong Kong.

Eligibility criteria: Inclusion Criteria:

* Secondary 1 (seventh year of formal education) to Secondary 4 Chinese students, who are studying local mainstream schools in Hong Kong.
* Able to read Chinese and speak either Cantonese or Mandarin.

Exclusion Criteria:

* Eligible students whose parents refuse to give consent to take part in the study.

Primary outcomes:
measure: Incidence of probable depression
timeFrame: 12 months
measure: Adolescent Depression Prediction Index (ADPI)
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: China Holiness Church Living Spirit College
city: Hong Kong
country: Hong Kong
facility: Christian Alliance SW Chan Memorial College (Christian Alliance SW Chan Memorial Secondary School)
city: Hong Kong
country: Hong Kong
facility: Ho Ngai College ( Sponsored By Sik Sik Yuen)
city: Hong Kong
country: Hong Kong
facility: Kit Sam Lam Bing Yim Secondary Schoo
Study officials:
affiliation: JC School of Public Health and Primary Care, Faculty of Medicine, CUHK
name: Xue Yang, PhD
role: PRINCIPAL_INVESTIGATOR
References: