Clinical trial NCT04373421: Effect of St. John's Wort and Olive Oils on the Postoperative Complications
Official title: Effect of St. John's Wort Oil and Olive Oil on the Postoperative Complications After Impacted Third Molar Surgery: Randomized, Double-blind Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Impacted Third Molar Tooth
Lead sponsor: Yuzuncu Yıl University
Sponsor class: OTHER
First posted: 2020-05-04
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Surgical removal of impacted third molars is one of the most frequent procedures carried out in the oral and maxillofacial surgery clinics. There are a varying range of postoperative complications including pain, edema and swelling. Antibiotics, analgesics and mouthwashes are usually prescribed for the treatment of these complications. Patients undergoing impacted third molar surgery are frequently prescribed chlorhexidine mouthwashes with/without benzydamine hydrochloride. However, to preclude the adverse effects of these chemical agents, there has been a search for plant-derived alternatives with anti-inflammatory, antibacterial and analgesic properties as part of the oral care routine following surgical removal of impacted third molars. However, there is no study investigating the comparison of different essential oils in the literature. Thus, this multicenter study was aimed to evaluate the effects of St. John's wort oil and virgin olive oil on the postoperative complications and compared with chlorhexidine gluconate plus benzydamine hydrochloride mouthwash after the removal of impacted wisdom teeth.This study was aimed to evaluate the effects of St. John's wort oil, virgin olive oil, and chlorhexidine gluconate plus benzydamine hydrochloride on the postoperative complications after the removal of impacted wisdom teeth.


Eligibility criteria: Inclusion Criteria:

* be 18-40 years old
* has unilateral mandibular impacted third molars with similar angulation position according to Winter's classification (mesio-angular) and similar impaction degree according to Pell \& Gregory's classification (class II, Level B).
* absence of any systemic disease
* absence of pregnancy/lactating state,

Exclusion Criteria:

* Patients with smoking habits, drug abuse, history of pericoronitis associated with the lower third molar
* not regularly coming to the controls

Primary outcomes:
measure: Postoperative Pain
timeFrame: Postoperatif 1st day
measure: Postoperative Jaw Function
timeFrame: Postoperatif 1st day
measure: Postoperative Swelling
timeFrame: Postoperative 1st day
measure: Postoperative Trismus
timeFrame: Postoperative 1st day
measure: Postoperative Pain
timeFrame: Postoperatif 2nd day
measure: Postoperative Jaw Function
timeFrame: Postoperatif 2nd day
measure: Postoperative Pain
timeFrame: Postoperatif 3rd day
measure: Postoperative Jaw Function
timeFrame: Postoperatif 3rd day
measure: Postoperative Swelling
timeFrame: Postoperative 3rd day
measure: Postoperative Trismus
timeFrame: Postoperative 3rd day
measure: Postoperative Pain
timeFrame: Postoperatif 4th day
measure: Postoperative Jaw Function
timeFrame: Postoperatif 4th day
measure: Postoperative Pain
timeFrame: Postoperatif 5th day
measure: Postoperative Jaw Function
timeFrame: Postoperatif 5th day
measure: Postoperative Pain
timeFrame: Postoperatif 6th day
measure: Postoperative Jaw Function
timeFrame: Postoperatif 6th day
measure: Postoperative Pain
timeFrame: Postoperatif 7th day
measure: Postoperative Jaw Function
timeFrame: Postoperatif 7th day
measure: Postoperative Swelling
timeFrame: Postoperative 7th day
measure: Postoperative Trismus
timeFrame: Postoperative 7th day
Secondary outcomes:
Other outcomes:
Locations:
city: Van
country: Turkey
facility: Van Yuzuncu Yil University, Faculty of Dentistry
Study officials:
affiliation: Van Yuzuncu Yil University, Faculty of Dentistry, Van, Tusba, Turkey, 65080
name: Serap KESKIN TUNC, PhD
role: STUDY_CHAIR
References: