Clinical trial NCT02407964: A Retrospective Study on Drug Induced Liver Injury in China
Official title: A Retrospective Epidemiologic Study on Incidence and Treatment Status of Hospitalized Drug Induced Liver Injury Patients in Mainland China
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Drug-Induced Liver Injury
Keywords: Drug-Induced Liver Injury
DILI
Lead sponsor: Drug Induced Liver Disease Study Group
Sponsor class: OTHER
Collaborators: name: Unimed Scientific Inc.
First posted: 2015-04-03
Enrollment: 15000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who were hospitalized during 2012 to 2014.

Brief summary: This is a multi-center, open-enrollment, retrospective, non-interventional epidemiologic study without any clinical treatment. Its primary objective is to understand 1) incidence of drug-induced liver injury, including incidences among all the hospitalized patient, among patients in department of hepatic diseases, digestive diseases, oncology, hematology etc., individually; 2) epidemiologic characteristics of drug-induced liver injury, including suspected medications, clinical types, histological characteristics, severity and outcomes.

Detailed description: This is a multi-center, open-enrollment, retrospective, non-interventional epidemiologic study without any clinical treatment. Its primary objective is to understand 1) incidence of drug-induced liver injury, including incidences among all the hospitalized patient, among patients in department of hepatic diseases, digestive diseases, oncology, hematology etc., individually; 2) epidemiologic characteristics of drug-induced liver injury, including suspected medications, clinical types, histological characteristics, severity and outcomes.

It investigates medical records of patients who were hospitalized during 2012 to 2014. Those patients should be diagnosed as drug-induced liver injury, drug-induced liver disease, drug-induced hepatitis, drug-induced hepatocirrhosis, drug-induced hepatic failure, or any other similar diagnosis of drug-induced liver injury nature.

Eligibility criteria: Inclusion Criteria:

* Any hospitalized patients who were diagnosed as drug-induced liver injury, drug-induced liver disease, drug-induced hepatitis, drug-induced hepatocirrhosis, drug-induced hepatic failure, or any other similar diagnosis of drug-induced liver injury nature.
* The drug-induced liver injury and similar diagnosis were not excluded the possibility of drug-induced nature.

Exclusion Criteria:

* Confirmed non-drug induced liver injury.
* Insufficient clinical data supporting the diagnosis of drug-induced liver injury.
* Liver injury resulted from poisons and chemicals.

Primary outcomes:
measure: diagnosis of drug-induced liver injury
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Taiyuan
country: China
facility: Department of gastroenterology,the second hospital of Shanxi medical university
state: Shanxi
city: Ankang
country: China
facility: Department of gastroentrology of Ankang city central hospital
city: Anqing
country: China
facility: Department of gastroenterology of Anqing municipal hospital
city: Anqing
country: China
facility: Department of infectious disease of Anqing municipal hospital
city: Baoding
country: China
facility: Department of tuberculosis of Baoding infectious disease hospital
city: Baoji
country: China
facility: Department of gastroentrology,the third hospital of PLA
city: Baoji
country: China
facility: Department of infectious disease of Baoji No.2 people's hospital
city: Baoji
country: China
facility: Department of infectious disease,the third hospital of PLA
city: Baoji
country: China
facility: Department of tuberculosis,the third hospital of PLA
city: Baotou
country: China
facility: Department of lymph&breast of Baotou tumor hospital
city: Beijing
country: China
facility: Department of breast disease,Tongzhou matermal&child health hospital of Beijing
city: Beijing
country: China
facility: Department of gastroenterology of Beijing Huairou hospital
city: Beijing
country: China
facility: Department of Hepatology of Beijing Ditan Hospital Capital Medical University
city: Beijing
country: China
facility: Department of hepatology of Peking university people's hospital
city: Beijing
country: China
facility: Department of infection of Peking university first hospital
city: Beijing
country: China
facility: Non infedtious liver disease diagnosis and treatment center,302 military hospital of China
city: Bengbu
country: China
facility: Department of gastroenterology,the first affiliated hospital of Bengbu medical college
city: Bengbu
country: China
facility: Department of infectious disease,the first affiliated hospital of Bengbu medical college
city: Bengbu
country: China
facility: Department of infectious disease,the No.123 hospital of PLA
city: Cangzhou
country: China
facility: Department of gastroenterology of Cangzhou central hospital
city: Changchun
country: China
facility: Department of gastroenterology,the fourth hospital of Jilin university
city: Changchun
country: China
facility: Department of infectious disaese,the fourth hospital of Jilin unversity
city: Changchun
country: China
facility: Department of infectious disease of Changchun infectious disease hospital
city: Changchun
country: China
facility: Department of rhenmatism,the affiliated hospital to Changchun University of Chinese medicine
city: Changji
country: China
facility: Department of infectious disease,people's hospital Changji hui autonomous prefecture Xinjiang
city: Changsha
country: China
facility: 2st department of hepatology,the first hospital of Changsha
city: Changsha
country: China
facility: 5st internal meidcine of Hunan chest hospital
city: Changsha
country: China
facility: Department of breast disease,the affiliated cancer hospital of Xiangya school
city: Changsha
country: China
facility: Department of infectious disease of Hunan provincial people's hospital
city: Changsha
country: China
facility: Department of infectious disease of Xiangya hospital central south university
city: Changsha
country: China
facility: Department of infectious disease,the second Xiangya hospital of central south university
city: Changsha
country: China
facility: Department of infectious disease,the third Xiangya hospital of central south university
city: Changsha
country: China
facility: Department of tuberculosis of Changsha central hospital
city: Changzhi
country: China
facility: Department of infectious disease,Heping hospital affiliated to Changzhi medical university
city: Chendu
country: China
facility: Department of hepatology of Chengdu tenth people's hospital
city: Chengdu
country: China
facility: Department of gastroenterlogy,affiliated hospital of Chenfdu University
city: Chengdu
country: China
facility: Department of gastroenterology,the 416th hospital of CNNC
city: Chenzhou
country: China
facility: Department of gastroenterology of Chenzhou No.1 people's hospital
city: Chenzhou
country: China
facility: Department of hepatology of Chenzhou No.2 people's hospital
city: Chenzhou
country: China
facility: Department of infectious disease,the fourth people's hospital of Chenzhou
city: Chizhou
country: China
facility: Department of infectious disease,the people's hospital of Chizhou
city: Chongqing
country: China
facility: Department of hepatology,Chongqing hospital of TCM
city: Chongqing
country: China
facility: Department of infectious disease of southwest hospital
city: Chongqing
country: China
facility: Department of infectious disease,the second affiliated hospital of Chongqing medical university
city: Daqing
country: China
facility: Department of gastroenterology of Daqing oilfield general hospital
city: Daqing
country: China
facility: Department of infectious disease of Daqing second hospital
city: Datong
country: China
facility: Department of hepatology of Datong fourth people's hospital
city: Dongying
country: China
facility: Department of gastroenterology,Qilu hospital of Shandong university
city: Dongying
country: China
facility: Department of infectious disease of Shengli oilfield general hospital
city: Dongying
country: China
facility: Department of infectious disease ，Shengli hospital of Shengli oilfield administration
city: Erdos
country: China
facility: Department of infectious disaese of Erdos second people's hospital
city: Erdos
country: China
facility: Department of oncology of Jungar Banner central hospital
city: Fenyang
country: China
facility: Department of infectious disease of Shanxi province Fenyang hospital
city: Foshan
country: China
facility: Department of infectious disease of Foshan first people's hospital
city: Fuqing
country: China
facility: Department of infectious disease of Fujian province Fuqing city hospital
city: Fuyang
country: China
facility: Department of hepatologym,No.2 people's hospital of Fuyang
city: Fuzhou
country: China
facility: Department of hepatic-biliary medicine,Fuzhou general hospital of Nanjing military command
city: Fuzhou
country: China
facility: Department of hepatic-biliary medicine,No.476 hospital of PLA
city: Fuzhou
country: China
facility: Department of hepatology of Fuzhou infectious disease hospital
city: Guangdong
country: China
facility: Department of digestive of Guangdong general hospital
city: Guangzhou
country: China
facility: Deaprtment of gastroenterology of Guangzhou first people's hospital
city: Guangzhou
country: China
facility: Department of gastroenterology of Guagdong general hospital
city: Guangzhou
country: China
facility: Department of gsatroenterology of Sun Yat-sen memorial hspital, Sun Yat-sen university
city: Guangzhou
country: China
facility: Department of infectious disease of Guangzhou women&children medical center
city: Guangzhou
country: China
facility: Department of infectious disease,Nanfang hospital of southern medical university
city: Guangzhou
country: China
facility: Department of science education&information of Guangzhou Huiai hospital
city: Guiyang
country: China
facility: Department of hematology,the affiliated hospital of Guiyang medical university
city: Guiyang
country: China
facility: Department of infectious disease of Guizhou provincial people's hospital
city: Guiyang
country: China
facility: Department of infectious disease,the affiliated hospital of Guiyang medical university
city: Haerbin
country: China
facility: 10st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention
city: Haerbin
country: China
facility: 1st mepartment of internal medicine Heilongjiang province center for tuberculosis control and prevention
city: Haerbin
country: China
facility: 4st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention
city: Haerbin
country: China
facility: 5st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention
city: Haerbin
country: China
facility: 7st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention
city: Haerbin
country: China
facility: 8st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention
city: Haerbin
country: China
facility: 9st department of internal medicine of Heilongjiang province center for tuberculosis control and prevention
city: Haerbin
country: China
facility: Department of infectious disease,No.211 hospital of PLA
city: Haerbin
country: China
facility: Department of infectious disease,the first affiliated hosptal of Haerbin medical university
city: Hainan
country: China
facility: Department of infection of Hainan general hospital
city: Hangzhou
country: China
facility: Department of infectious disease of Hangzhou Xiaoshan district first people's hospital
city: Hangzhou
country: China
facility: Department of infectious disease of Sir Run Run Shaw hospital,Zhejiang unicersity school of medicine
city: Hanzhong
country: China
facility: 1st department of respiration of Hanzhong second people's hospital
city: Hanzhou
country: China
facility: Department of infection of Hanzhou first people's hospital
city: Hefei
country: China
facility: Department of gastroenterology,the first affiliated hospital of Anhui medical university
city: Hefei
country: China
facility: Department of infectious disease of Anhui provincial hospital
city: Hefei
country: China
facility: Department of infectious disease of Hefei infectious disease hospital
city: Hefei
country: China
facility: Department of infectious disease,No.105 hospital of PLA
city: Hefei
country: China
facility: Department of infectious disease,the first affiliated hospital of Anhui university of Chinese medicine
city: Heilongjiang
country: China
facility: Department of hematology of First affiliated hospital,Heilongjiang university of Chinese medicine
city: Hengyang
country: China
facility: Department of infectious disease,the first affiliated hospital of university of south China
city: Hohhot
country: China
facility: Department of hepatology of Hohhot second hospital
city: Huai'an
country: China
facility: Department of hepatology of Huai'an No.4 people's hospital
city: Huai'an
country: China
facility: department of oncology,Huaiyin hospital of Huai'an city
city: Huizhou
country: China
facility: Department of infectious disease,people's hospital of Puluo county
city: Huizhou
country: China
facility: Department of oncology,people's hospital of Puluo county
city: Ili
country: China
facility: Department of infectious disease of Yili friendship hospital
city: Inner Mongolia
country: China
facility: Department of gastroenterology of inner mongolia forestry general hospital
city: Inner Mongolia
country: China
facility: Department of hepatology of Inner Mongolia international Mongolian medicine hospital
city: inner Mongolia
country: China
facility: Department of hepatology of No.253 hospital of the PLA
city: Inner Mongolia
country: China
facility: Department of infection, the affiliated hospital of inner mongolia medical hospital
city: Inner Mongolia
country: China
facility: Department of infection,the first affiliated hospital of Baotou medical university
city: Inner Mongolia
country: China
facility: Department of infectious disease of inner mongolia people's hospital
city: Inner Mongolia
country: China
facility: Department of tuberculosis of The Inner Mongolia Autonomous Region fourth hospital
city: Jiamusi
country: China
facility: Department of hematology, first affiliated hospital of Jiamusi university
city: Jiayuguan
country: China
facility: Internal medicine,the 404 hospital of China national nuclear
city: Jilin
country: China
facility: Department of gastroenterology of Beihua university affiliated hospital
city: Jilin
country: China
facility: Department of gastroenterology,hepatology hospital of Jilin province
city: Jilin
country: China
facility: Department of gastroentrology of Jilin integrated TCM&western medicine hospital
city: Jilin
country: China
facility: Department of hepatology,hepatology hospital of Jilin province
city: Jilin
country: China
facility: Department of hepatology,the first hospital oof Jilin university
city: Jilin
country: China
facility: Department of infectious disease of Beihua university affiliated hospital
city: Jinan
country: China
facility: 1st department of hepatology of Jinan hospital for infectious disease
city: Jinan
country: China
facility: Department of endocrinology of Shangdong provincial hospital
city: Jinan
country: China
facility: Department of gastroenterology of Jinan central hospital
city: Jinan
country: China
facility: Department of gastroenterology,Qilu hospital of Shandong university
city: Jinan
country: China
facility: Department of gastroenterology,the second hospital of Shandong university
city: Jinan
country: China
facility: Department of hepatology of Shandong province Qianfoshan hospital
city: Jinan
country: China
facility: Department of hepatology of Shandong provincial hospital of Chinese medicine
city: Jinan
country: China
facility: Department of rheumatology of Shandong provincial hospital
city: Jinan
country: China
facility: Internal medicine of Jinan city Lixia district people's hospital
city: Jincheng
country: China
facility: Department of infectious disease of Jincheng anthracite mining group general hospital
city: Jincheng
country: China
facility: Department of infectious disease of Zezhou county people's hospital
city: Jingmen
country: China
facility: 2st department of hepatology of Jingmen No.2 people's hospital
city: Jingmen
country: China
facility: Department of gastroenterology of Jingmen No.1 people's hospital
city: Jingmen
country: China
facility: Department of gastroenterology ward 2 of Jingmen No.1 people's hospital
city: Jingmen
country: China
facility: Department of infectious disease of Jingmen No.2 people's hospital
city: Jingzhou
country: China
facility: 1st internal medicine of Jingzhou hospital for infectious disease
city: Jingzhou
country: China
facility: Department of infectious disease of Jingzhou central hospital
city: Jinzhong
country: China
facility: Department of gastroenterology of Jinzhong City Yuci district people's hospital
city: Jinzhong
country: China
facility: Department of gastroenterology of Qixian county people's hospital
city: Jinzhong
country: China
facility: Department of gastroenterology,the second people's hospital of Jinzhong
city: Jinzhong
country: China
facility: Department of gastroentrology,the first people's hospital of Jinzhong
city: Kaifeng
country: China
facility: Department of infectious disease,the first affiliated hospital of Henan university
city: Kashgar
country: China
facility: Department of infectious disease of Kashgar prefecture first people's hospital
city: Kunming
country: China
facility: Department of gastroenterology of Xishan district people's hospital
city: Kunming
country: China
facility: Department of gastroenterology of Yunnan first people's hospital
city: Kunming
country: China
facility: Department of gastroenterology,the first affiliated hospital of Kunming medical university
city: Kunming
country: China
facility: Department of gastroentrology,the first hospital of Kunming
city: Kunming
country: China
facility: Department of infectious disease,Kunming general hospital of Chengdu military
city: Kunming
country: China
facility: Department of infectious disease,the first affiliated hospital of Kunming medical university
city: Kunming
country: China
facility: Department of rheumatology of Yunnan first people's hospital
city: Kunming
country: China
facility: Hepatology center,the second affiliated hospital of Kunming medical university
city: Lanzhou
country: China
facility: Department of hepatology, Gansu provincial hospital of TCM
city: Lanzhou
country: China
facility: Department of infectious disease of Lanzhou military general hospital
city: Lanzhou
country: China
facility: Department of infestious disease,the first hospital of Lanzhou university
city: Lanzhou
country: China
facility: outpatient of pulmonary hospital of Lanzhou
city: Leqing
country: China
facility: Department of infectious disease of Leqing people's hospital
city: Liaocheng
country: China
facility: Department of hepatology of Liaocheng city infectious disease hospital
city: Linfen
country: China
facility: Department of hepatology &respiration of Linfen infectious disease hospital
city: Linyi
country: China
facility: Department of endocrinolnogy of Linyi people's hospital
city: Linyi
country: China
facility: Department of hepatology of Linyi people's hospital
city: Linyi
country: China
facility: Department of tuberculosis of Linyi people's hospital
city: Lu'an
country: China
facility: Department of gastroenterology of Lu'an people's hospital
city: Luoyang
country: China
facility: Department of gastroenterology of Luoyang third people's hospital
city: Luoyang
country: China
facility: Department of infectious disease of Luoyang central hospital
city: Luzhou
country: China
facility: Department of infectios disease,the affiliated hospital of southwest hospital
city: Mudanjiang
country: China
facility: Department of hepatology ward 1 of Mudanjiang Kangan hospital
city: Mudanjiang
country: China
facility: Department of hepatology ward 2 of Mudanjiang Kangan hospital
city: Mudanjiang
country: China
facility: Department of hepatology wardf 10 of Mudanjiang Kangan hospital
city: Mudanjiang
country: China
facility: Department of hepatology wardf 3 of Mudanjiang Kangan hospital
city: Mudanjiang
country: China
facility: Department of hepatology wardf 4 of Mudanjiang Kangan hospital
city: Mudanjiang
country: China
facility: Department of hepatology wardf 9 of Mudanjiang Kangan hospital
city: Mudanjiang
country: China
facility: Department of tuberculosis of ward 11 of Mudanjiang Kangan hospital
city: Mudanjiang
country: China
facility: Department of tuberculosis ward 5 of Mudanjiang Kangan hospital
city: Mudanjiang
country: China
facility: Department of tuberculosis ward 6 of Mudanjiang Kangan hospital
city: Mudanjiang
country: China
facility: Department of tuberculosis ward 7 of Mudanjiang Kangan hospital
city: Mudanjiang
country: China
facility: Department of tuberculosis ward 8 of Mudanjiang Kangan hospital
city: Nanchang
country: China
facility: Department of gastroenterology of Jiangxi provincial people's hospital
city: Nanchang
country: China
facility: Department of gastroenterology of the second affiliated hospital to Nanchang university
city: Nanchang
country: China
facility: Department of tuberculosis of Jiangxi provincial chest hospital
city: Nanjing
country: China
facility: Deparment of oncology, Nanjing hospital of TCM
city: Nanjing
country: China
facility: Department of hematology of Nanjing Jiangning hospital
city: Nanjing
country: China
facility: Department of hematology, Jiangsu province hospital of TCM
city: Nanjing
country: China
facility: Department of hepatology,No.81 hospital of PLA
city: Nanjing
country: China
facility: Department of infection of Jiangsu province hospital
city: Nanjing
country: China
facility: Department of infection of Nanjing drum tower hospital
city: Nanjing
country: China
facility: Department of infection,the second hospital of Nanjing
city: Nanjing
country: China
facility: Department of infectious disease of Nanjing Jiangbei people's hospital
city: Nanjing
country: China
facility: Department of infectious,Jiangsu procince hospital of TCM
city: Nanjing
country: China
facility: Department of oncology , Jiangning hospital of Nanjing city
city: Nanjing
country: China
facility: Department on tuberculosis of Nanjing chest hospital
city: Nanning
country: China
facility: Department of gastroenterology,the first affiliated hospital of Guangxi medical university
city: Nanning
country: China
facility: Department of hepatology,the first affiliated hospital of Guangxi university of Chinese medicine
city: Nanning
country: China
facility: Department of oncology，the first affiliated hospital of Guangxi university of Chinese medicine
city: Ningbo
country: China
facility: Department of gastroenterology of Ningbo medical treatment center Lihuili hospital
city: Ningbo
country: China
facility: Department of gastroenterology,Yinzhou hospital affiliated to medical school of Ningbo university
city: Ningbo
country: China
facility: Department of hematology of Ningbo medical treatment center Lihuili hospital
city: Ningbo
country: China
facility: Department of hepatology of Ningbo No.2 hospital
city: Ningbo
country: China
facility: Department of hepatology,No.113 hospital of PLA
city: Ningbo
country: China
facility: Department of psychiatry of Ningbo Kangning hospital
city: Pingdingshan
country: China
facility: Department of tuberculosis of Pingdingshan third people's hospital
city: Pingxiang
country: China
facility: Department of gastroenterology of Jiangxi Pingxiang people's hospital
city: Pingxiang
country: China
facility: Department of gastroenterology,Pingxiang city hospital of Chinese medicine
city: Pingyang
country: China
facility: Department of infedtious disease of Pingyang county hospital of Chinese medicine
city: Puyang
country: China
facility: Department of infectious disease,Puyang oilfield general hospital
city: Puyang
country: China
facility: Department of tuberculosis,the fifth people hospital of Puyang
city: Qingdao
country: China
facility: Department of digestive,the affiliated hospital of Qingdao university
city: Qingdao
country: China
facility: Department of endocrinology,the affiliated hospital of Qingdao university
city: Qingdao
country: China
facility: Department of gastroenterology of Qingdao municipal hospital
city: Qingdao
country: China
facility: Department of hepatology,the affiliated hospital of Qingdao university
city: Qinghai
country: China
facility: Department of digestive of Qinghai provincial people's hospital
city: Qinghai
country: China
facility: Department of hepatology,Qinghai province hospital for infectious disease
city: Qinghai
country: China
facility: Deqpartment of gastroenterology of Qinghai university affiliated hospital
city: Qinhuangdao
country: China
facility: Department of gastroenterology,the third hosital of Qinhuangdao
city: Qinhuangdao
country: China
facility: Department of hepatology,the third hospital of Qinhuangdao
city: Qiqihar
country: China
facility: Department of infectious disease of Qiqihar infectious disease hospital
city: Qiqihar
country: China
facility: Department og gastroenterology,the first hospital of Qiqihar city
city: Ruian
country: China
facility: Department of infectious disease of Ruian people's hospital
city: Sanmenxia
country: China
facility: Department of gastroenterology of Sanmenxia central hospital
city: Sanmenxia
country: China
facility: Department of hematology of Sanmenxia central hospital
city: Sanmenxia
country: China
facility: Department of infectious disease of Sanmenxia central hospital
city: Sanya
country: China
facility: Department of gastroenterology,No.301 hospital Sanya branch
city: Shanghai
country: China
facility: Clinical research center for tuberculosis of Shanghai pulmonary hospital
city: Shanghai
country: China
facility: Department of Digestive Diseases of Shanghai Tongji Hospital
city: Shanghai
country: China
facility: Department of Digestive Diseases of The Renji Hospital
city: Shanghai
country: China
facility: Department of digestive of Shanghai Tongji hospital
city: Shanghai
country: China
facility: Department of gastroenterolgy of Huadong hispital affiliated to Fudan university
city: Shanghai
country: China
facility: Department of gastroenterology,the affiliated Zhongshan hospital of Fudan university
city: Shanghai
country: China
facility: Department of hepatocirrhosis of Shuguang hospital affiliated Shanghai University of T.C.M
city: Shanghai
country: China
facility: Department of hepatology of No.85 hospital of PLA
city: Shanghai
country: China
facility: Department of infection of No.85 hospital of PLA
city: Shanghai
country: China
facility: Department of Infection of Ruijin Hospital Shanghai Jiaotong University School of Medicine
city: Shanghai
country: China
facility: Department of infectious disease of Longhua hospital affiliated to Shianghai univesity of Chinese medicine
city: Shanghai
country: China
facility: Department of infectious disease of Shanghai Songjiang district people's hospital
city: Shanghai
country: China
facility: Department of infectious disease of Tongren hospital
city: Shanghai
country: China
facility: Department of infectious disease,Huashan hospital affiliated to Fudan university
city: Shanghai
country: China
facility: Department of oncology of Shanghai Putuo district central hospital
city: Shanghai
country: China
facility: Department of oncology of the sixth people's hospital affiliated to Shanghai Jiaotong university
city: Shanghai
country: China
facility: Department of pediatrics of Shanghai first people's hospital Songjiang branch
city: Shangxi
country: China
facility: Department of digestive of the second affiliated hospital of Xi'an jiaotong university
city: Shangxi
country: China
facility: Department of infection of the second affiliated hospital of Xi'an jiaotong university
city: Shanluo
country: China
facility: Department of gastroenterology of Shanluo central hospital
city: Shanluo
country: China
facility: Department of infectious disease of Shanluo central hospital
city: Shaoxing
country: China
facility: Department of infectious disease of Shaoxing central hospital
city: Shaoyang
country: China
facility: Department of infectious disease of Shaoyang central hospital
city: Shenyang
country: China
facility: Department of infectious disease,Shengjing hospital of China medical university
city: Shenzhen
country: China
facility: Department of hepatology of Shenzhen third people's hospital
city: Shenzhen
country: China
facility: Department of infectious disease of Shenzhen third people's hospital
city: Shenzhen
country: China
facility: Department of pulmonary dedicine of Shenzhen third people's hospital
city: Shijiazhuang
country: China
facility: Department of gastroenterology of Hebei general hospital
city: Shijiazhuang
country: China
facility: Department of gastroenterology,the first hospital of Hebei medical university
city: Shijiazhuang
country: China
facility: Department of hematology,the first hospital of Hebei medical university
city: Shijiazhuang
country: China
facility: Department of hepatology,the first hospital of Hebei medical university
city: Shijiazhuang
country: China
facility: Department of hepatology，the third hodpital of Hebei medical university
city: Shijiazhuang
country: China
facility: Department of tuberculosis of Hubei province chest hospital
city: Shiyan
country: China
facility: 2st department of gastroenterology of Shiyan people's hospital
city: Shiyan
country: China
facility: Department of infectious disease of Dongfeng company general hospital
city: Shiyan
country: China
facility: Department of infectious disease of Taihe hospital
city: Shiyan
country: China
facility: Department of tuberculosis of Xiyuan hospital of Shiyan city
city: Shunde
country: China
facility: Department of infestious disease,the first people's hospital of Shunde
city: Songyuan
country: China
facility: Department of gastroenterology of Songyuan central hospital
city: Songyuan
country: China
facility: Department of hepatology of Jilin oilfiled general hospital
city: Suzhou
country: China
facility: Department of infectious disease of Suzhou municipal hospital
city: Suzhou
country: China
facility: Department of infectious disease,the fifth people's hospital of Suzhou
city: Taian
country: China
facility: Department of i fectious disease of Taian city central hospital
city: Taian
country: China
facility: Department of tuberculosis of Taian cancer hospital
city: Taiyuan
country: China
facility: 1st department of tuberculosis of Taiyuan fourth people's hospital
city: Taiyuan
country: China
facility: Department of hepatology,Shanxi provincial hospital of Chinese medicine
city: Taiyuan
country: China
facility: Department of tuberculosis of Taiyuan fourth people's hospital
city: Taizhou
country: China
facility: Department of hematology&oncology,Taizhou hospital of Zhejiang province
city: Tianchang
country: China
facility: Department of infectious disease of Tianchang people's hospital
city: Tianjin
country: China
facility: Department of hepatology of Tianjin first hospital
city: Tianjin
country: China
facility: Department of hepatology of Tianjin third central hospital
city: Tianjin
country: China
facility: Department of hepatology,first teaching hospital of Tianjin university
city: Tianjin
country: China
facility: Department of hepatology,The affiliated hospital of logistics university of people's armed police force
city: Tianjin
country: China
facility: Department of oncology of Tianjin medical university general hospital
city: Tianjin
country: China
facility: Department of rheumatology of Tianjin first center hospital
city: Tibet
country: China
facility: Department of infestious disaese of Tibet autonomous prefecture people's hospital
city: Tonghua
country: China
facility: 1st department of oncology of Tonghua central hospital
city: Tonghua
country: China
facility: 3st department of oncology of Tonghua central hospital
city: Tonghua
country: China
facility: Department of oncology of Tonghua second people's hospital
city: Tonghua
country: China
facility: Department of oncology&hematology of Tonghua people's hospital
city: Tongliao
country: China
facility: Department of infectious disease of Tongliao infectious disease hospital
city: Urumqi
country: China
facility: Department of hepatology of The Xinjiang production and construction Corps hospital
city: Urumqi
country: China
facility: Department of infectious disease of URUMQI friendship hospital
city: Weifang
country: China
facility: 2st department of tuberculosis of Weifang No.2 people's hospital
city: Weifang
country: China
facility: Department of gastroenterology of Weifang people's hospital
city: Weihai
country: China
facility: Department of gastroenterology of Weihai central hospital
city: Weihai
country: China
facility: Department of gastroenterology of Weihai municipal hospital
city: Weinan
country: China
facility: Department of infectious disease of Weinan central hospital
city: Wenling
country: China
facility: Department of infectious disease,the first people's hospital of Wenling
city: Wenzhou
country: China
facility: Department of hematology of the first affiliated hospital of Wenzhou medical university
city: Wenzhou
country: China
facility: Department of infectious disease of Wencheng county people's hospital
city: Wenzhou
country: China
facility: Department of infectious disease,Wenshou hospital of Chinesemedicine
city: Wuhai
country: China
facility: Department of oncology of Wuhai people's hospital
city: Wuhan
country: China
facility: 1st internal medicine of Wuhan institute for tuberculosis control
city: Wuhan
country: China
facility: 3st internal medicine of Wuhan institute for tuberculosis control
city: Wuhan
country: China
facility: 4st internal medicine of Wuhan institute for tuberculosis control
city: Wuhan
country: China
facility: 5st internal medicine of Wuhan institute for tuberculosis control
city: Wuhan
country: China
facility: Departmeent of gastroenterology of fifth hodpital in Wuhan
city: Wuhan
country: China
facility: Department of gastroenterology of Wuhan integrated TCM&western medicine hospital
city: Wuhan
country: China
facility: Department of gastroenterology of Wuhan union hospiital
city: Wuhan
country: China
facility: Department of gastroenterology,the central hospital of Wuhan
city: Wuhan
country: China
facility: Department of gastroenterology,Wuhan general hospital of Guangzhou military
city: Wuhan
country: China
facility: Department of hepatology of Wuhan seventh hospital
city: Wuhan
country: China
facility: Department of hepatology,Hubei provincial hospital of TCM
city: Wuhan
country: China
facility: Department of hepatology,Wuhan general hospital of Guangzhou military
city: Wuhan
country: China
facility: Department of infectious disease of Puren hospital
city: Wuhan
country: China
facility: Department of infectious disease of Wuhan iron and steel(group) corp. staff hospital
city: Wuhan
country: China
facility: Department of infectious disease of Wuhan iron and steel(group) Crop. second staff hospital
city: Wuhan
country: China
facility: Department of infectious disease of Wuhan union hospital
city: Wuhan
country: China
facility: Department of infectious disease(north fifth ward) of Wuhan medical treatment center
city: Wuhan
country: China
facility: Department of infectious disease（north fourth ward） of Wuhan medical treatment center
city: Wuhan
country: China
facility: Department of infectious disease（north sixth ward) of Wuhan medical treatment center
city: Wuhan
country: China
facility: Department of infectious disease（south second ward） of Wuhan medical treatment center
city: Wuhan
country: China
facility: Department of oncology,Renmin hospital of Hubei university
city: Wuhan
country: China
facility: Department of tuberculosis(south fifth ward) of Wuhan medical treatment center
city: Wuhan
country: China
facility: Department of tuberculosis(south first ward) of Wuhan medical treatment center
city: Wuhan
country: China
facility: Department of tuberculosis(south fourth ward) of Wuhan medical treatment center
city: Wuhan
country: China
facility: Department of tuberculosis(south sixth ward) of Wuhan medical treatment center
city: Wuhu
country: China
facility: Department of gastroenterology,the first affiliated hospital of Wannan medical college
city: Wuxi
country: China
facility: Department of oncology of Wuxi No.2 people's hospital
city: Xi'an
country: China
facility: 1st internal medicine of Shangxi province tuberculosis prevention and treatment institute
city: Xi'an
country: China
facility: 2st department of gastroenterology of Shaanxi provincial people's hospital
city: Xi'an
country: China
facility: 3st internal medicine of Shanxi province tuberculosisi prevention and treatment institute
city: Xi'an
country: China
facility: Department of gastroenterology of Xi'an children's hospital
city: Xi'an
country: China
facility: Department of gastroenterology of Xijing hospital
city: Xi'an
country: China
facility: Department of gastroenterology,No.451 hospital of PLA
city: Xi'an
country: China
facility: Department of gastroenterology,the first affiliated hospital of Xi'an Jiaotong university
city: Xiamen
country: China
facility: Department of infectious disease,the first affiliated hospital of Xiamen university
city: Xiangtan
country: China
facility: Departmenr of infectious disease,the first people's hospital of Xiangtan city
city: Xiangtan
country: China
facility: Department of infectious disease of Xiangtan central hospital
city: Xiangyang
country: China
facility: 2st department of gastroenterology of Xiangyang central hospital
city: Xiangyang
country: China
facility: Department of gastroenterology B zone of Xiangyang No.1 people's hospital
city: Xianyang
country: China
facility: Department of gastroenterology of Xianyang central hosppital
city: Xianyang
country: China
facility: Department of infectious disease of Xianyang central hospital
city: Xianyang
country: China
facility: Department of infectious disease,the affiliated hospital of Shaanxi university of Chinese medicine
city: Xianyang
country: China
facility: Department of tuberculosis of Xianyang central hospital
city: Xinjiang
country: China
facility: 1st department of oncology,Xinjiang Uyghur aotonomous region hospital of Chinese medicine
city: Xinjiang
country: China
facility: 4st department of tuberculosis,chest hospital of Xinjiang Uyghur aotonomous region of the PRC
city: Xinjiang
country: China
facility: Department of hepatology,Xinjiang Uyghur aotonomous region hospital of Chinese medicine
city: Xinjiang
country: China
facility: Department of infectious disease of Xinjiang general hospital of CAPF
city: Xinjiang
country: China
facility: Department of infectious disease of Xinjiang Uyghur aotonomous region people's hospital
city: Xinjiang
country: China
facility: Department of infectious,the first affiliated hospital of Xinjiang medical university
city: Xinjian
country: China
facility: 2st department of oncology,Xinjiang Uyghur aotonomous region hospital of Chinese medicine
city: Xinxiang
country: China
facility: 2st department of infectious disease,the first affiliated hospital of Xinxiang medical university
city: Xinyu
country: China
facility: Department of gastroenterology,Xinyu hospital of Chinese medicine
city: Xinzhou
country: China
facility: Department of science education of Xinzhou city people hospital
city: Ya'an
country: China
facility: Department of infectious disease of Ya'an people's hospital
city: Yanan
country: China
facility: Department of gastroenterology of Yanan university affiliated hospital
city: Yanan
country: China
facility: Department of respiration of Yanan university affiliated hospital
city: Yanbian
country: China
facility: Department of psychiatry of Yanbian brain hospital
city: Yancheng
country: China
facility: Department of hepatology of Yancheng second people's hospital
city: Yancheng
country: China
facility: Department of infectious disease of Yancheng city No.1 people's hospital
city: Yangquan
country: China
facility: Department of gastroenterology of Yangguan coalmine group general hospital
city: Yangzhou
country: China
facility: Department of digestive of northern Jiangsu people's hospital
city: Yangzhou
country: China
facility: Department of infectious disease,the third hospital of Yangzhou city
city: Yangzhou
country: China
facility: Department of oncology of Northern Jiangsu peolple's hospital
city: Yanji
country: China
facility: Department of gastroenterology of Yanji hospital
city: Yichang
country: China
facility: Department of gastroenterology of Yichang first people's hospital
city: Yichang
country: China
facility: Department of infectious disease of China Gezhouba group central hospital
city: Yichang
country: China
facility: Department of infectious disease of Yichang central people's hospital
city: Yinchuan
country: China
facility: Department of infectious,general hospital of Ningxia medical university
city: Yiyang
country: China
facility: Department of hepatology of Yiyang infectious disease hospital
city: Yulin
country: China
facility: Department of infectious disease,the first hospital of Yulin
city: Yuncheng
country: China
facility: Department of hepatology of Yuncheng infectiuos disease hospital
city: Yuyao
country: China
facility: Department of infectious of Yuyao people's hospital
city: Zhengzhou
country: China
facility: 1st department of respiration of Zhengzhou sixth people's hospital
city: Zhengzhou
country: China
facility: 7st department of respiration of Zhengzhou sixth people's hospital
city: Zhengzhou
country: China
facility: Department of digestive of Henan provincial people's hospital
city: Zhengzhou
country: China
facility: Department of gastroenterology,the fifth affiliated hospital of Zhengzhou
city: Zhengzhou
country: China
facility: Department of gastroenterology,the first affiliated hospital of Henan university of TCM
city: Zhengzhou
country: China
facility: Department of gastroentrology of Zhengzhou central hospital
city: Zhengzhou
country: China
facility: Department of hepatic-biliary meidicine,No.153 hospital of PLA
city: Zhengzhou
country: China
facility: Department of infection,the first affiliated hospital of Zhengzhou university
city: Zhengzhou
country: China
facility: Department of infectious disaese of Henan provincial people's hospital
city: Zhengzhou
country: China
facility: Department of tuberculosis of Zhengzhou 6th people's hospital
city: Zhengzhou
country: China
facility: lienic-gastric-hepatic medicine,Zhengzhou hospital of Chinese medicine
city: Zhuzhou
country: China
facility: Department of infectious disease of Zhuzhou central hospital
city: Zibo
country: China
facility: Department of digestive of Yiyuan county people's hospital
city: Zibo
country: China
facility: Department of rheumatology,central hospital of Zibo
Study officials:
affiliation: RenJi Hospital
name: Yimin Mao, MD
role: STUDY_CHAIR
affiliation: No. 85 Hospital of PLA
name: Chengwei Chen, MD
role: STUDY_CHAIR
References:
citation: Li J, Zhang J, Xu X, Fang W, Qu S, Jin F, Zhou J, Han X, Raza HK, Li X, Mao Y. Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database. Expert Rev Clin Pharmacol. 2021 Dec;14(12):1543-1550. doi: 10.1080/17512433.2021.1981859. Epub 2021 Sep 22.