louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02304510: Prevalence of Heavy Menstrual Bleeding in Female Population Living in Beijing
Official title: Prevalence of Heavy Menstrual Bleeding in Female Population Living in Beijing
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Menorrhagia
Keywords: Prevalence
Menorrhagia
Lead sponsor: Peking University
Sponsor class: OTHER
Collaborators: name: Bayer
First posted: 2014-12-02
Enrollment: 2455
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: residents of Beijing

Brief summary: The purpose of the study is to estimate the prevalence of heavy menstrual bleeding (HMB) in females aged between 18 and 50 years old living in Bejing.

Detailed description: This study is an observational, cross-sectional study. A representative sample of 2800 eligible women with different occupations such as farmers, service providers, workers, professional specialists, students and civil servants will be recruited. A cluster sampling method with probability proportional to the distribution of occupation in women in Beijing will be used. Demographic data will be collected by questionnaire. Menstrual bleeding will be evaluated by Pictorial Blood loss Assessment Chart (PBAC). According to the international definition of HMB, a PBAC score more than 100 is considered as HMB.

Eligibility criteria: Inclusion Criteria:

* Females aged between 18 and 50 years (inclusive)
* Stay in Beijing for more than 6 months
* Signed ICF was obtained

Exclusion Criteria:

* Not achieve the menarche
* With the last menstruation more than one year ago
* Experienced amenorrhea, currently take hormone therapy to induce menstruation
* Had undergone a hysterectomy
* Currently breastfeeding a baby
* Being pregnant

Primary outcomes:
measure: Prevalence of HMB
timeFrame: from date of inclusion until the end of the study currently planned (about 7 months)
Secondary outcomes:
measure: Prevalence of HMB in different subgroups
timeFrame: from date of inclusion until the end of the study currently planned (about 7 months)
measure: Identify risk factors associated with HMB
timeFrame: from date of inclusion until the end of the study currently planned (about 7 months)
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University Health Science Center
Study officials:
affiliation: Peking University Health Science Center
name: Siyan Zhan, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06204510: Effects of Complex Decongestive Therapy on Proprioception, Balance and Tactile Sense
Official title: Effects of Complex Decongestive Therapy on Proprioception, Balance and Tactile Sense in Lymphedema After Cancer Surgery: A Prospective Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Lymphedema of Leg
Sensitisation
Balanced
Therapy-Associated Cancer
Lead sponsor: Selcuk University
Sponsor class: OTHER
First posted: 2024-01-12
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to investigate the effects of complex decongestive physiotherapy (CDP) on propriseception, balance and sensation in patients with secondary lymphedema that develops in the lower extremities after cancer surgery.


Eligibility criteria: Inclusion Criteria:

* Being between the ages of 18-65
* Having unilateral lymphedema in the lower extremity secondary to cancer surgery

Exclusion Criteria:

* Having bilateral lower extremity lymphedema
* Having an active infection
* Having a mental cognitive disorder
* Being at a level where communication and cooperation cannot be established
* Situations where manual lymphatic drainage is contraindicated (such as severe heart failure and/or uncontrolled rhythm disorder, uncontrolled hypertension, pregnancy, presence of thrombus, active infection)
* Presence of metastasis

Primary outcomes:
measure: Evaluation of Proprioception
timeFrame: 10 minutes
measure: One-leg Standing Test
timeFrame: 5 minutes
measure: 30 Seconds Sit-Stand-on-Chair Test:
timeFrame: 5 minutes
measure: Softt Touch Sense
timeFrame: 5 minutes
measure: Two Point Discrimination
timeFrame: 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Konya
country: Turkey
facility: Selcuk University
Study officials:
References:
Clinical trial NCT03960710: Automatic Segmentation of Polycystic Liver
Official title: Automatic Segmentation by a Convolutional Neural Network (Artificial Intelligence - Deep Learning) of Polycystic Livers, as a Model of Multi-lesional Dysmorphic Livers
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Polycystic Liver Disease
Polycystic Hepatorenal Disease
Liver Injury
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2019-05-23
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with hepato-renal polycystosis, with or without surgery

Brief summary: Assessing the volume of the liver before surgery, predicting the volume of liver remaining after surgery, detecting primary or secondary lesions in the liver parenchyma are common applications that require optimal detection of liver contours, and therefore liver segmentation.

Several manual and laborious, semi-automatic and even automatic techniques exist.

However, severe pathology deforming the contours of the liver (multi-metastatic livers...), the hepatic environment of similar density to the liver or lesions, the CT examination technique are all variables that make it difficult to detect the contours. Current techniques, even automatic ones, are limited in this type of case (not rare) and most often require readjustments that make automatisation lose its value.

All these criteria of segmentation difficulties are gathered in the livers of hepatorenal polycystosis, which therefore constitute an adapted study model for the development of an automatic segmentation tool.

To obtain an automatic segmentation of any lesional liver, by exceeding the criteria of difficulty considered, investigators have developed a convolutional neural network (artificial intelligence - deep learning) useful for clinical practice.


Eligibility criteria: Inclusion Criteria:

* Patients ≥ 18 years old
* Patients with hepato-renal polycystosis, with or without surgery
* Patients with at least one abdominal-pelvic CT scan without injection or with injection between January 1, 2016 and August 2018
* Patients with good quality and available images

Exclusion Criteria:

* Patients with no CT scan images available
* Patients with bad quality of CT scan images

Primary outcomes:
measure: Test of automatic segmentation by the convolutional neural network on these group and collection of data set
timeFrame: At 4 months after randomization
Secondary outcomes:
Other outcomes:
Locations:
city: Lyon
country: France
facility: Service de radiologie - Pavillon B - Cellule Recherche imagerie, Hôpital Edouard Herriot (HCL)
Study officials:
References:
Clinical trial NCT03328910: The Relationship Between the SPI and the Postop ED
Official title: The Relationship Between the Surgical Pleth Index (SPI) and the Postoperative Emergence Delirium in Pediatric Patients After General Anesthesia
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: General Anesthesia
Keywords: Emergence Delirium
pulse oximetry
Children, Preschool
Lead sponsor: Daegu Catholic University Medical Center
Sponsor class: OTHER
First posted: 2017-11-01
Enrollment: 0
Sex: ALL
Minimum age (years): 2
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pediatric patients aged 2-7 years with an American Society of Anaesthesiologists physical status (ASA PS) of 1 or 2, who were planned to undergo ophthalmology surgery requiring general anesthesia.

Brief summary: Surgical plethysmography index (SPI) is a device that can noninvasively monitor the balance between the nociception and ant-nociception using pulse photoplethysmographic amplitude (PPGA) and heart rate obtained through an oxygen saturation measuring device. SPI has recently been studied as a useful tool to monitor the stress response of patients due to surgery or anesthesia and to guide the appropriate use of analgesics/anesthetics. However, these SPI devices have been developed for adults and have not been studied in pediatric patients with relatively high heart rates, and no direct effects on post-operative arousal excitability have been reported.


Eligibility criteria: Inclusion Criteria:

* Pediatric patients aged 2-7 years with an American Society of Anaesthesiologists physical status (ASA PS) of 1 or 2, who were planned to undergo ophthalmology surgery requiring general anesthesia.

Exclusion Criteria:

* ASA PS 3 or 4
* Presence of developmental delays or neurological diseases
* History of allergies or contraindications to the use of ketamine (increased intracranial pressure, open-globe injury, or a psychiatric or seizure disorder)
* treatment with beta-receptor blockers, beta-receptor agonists or any other drug suspected to interact with the sympathovagal balance
* diseases with impairment of sensitivity (diabetes, polyneuropathy, peripheral arterial obstructive disease et etc)
* pacemaker therapy
* dermal diseases with the affection of the forearm/hand

Primary outcomes:
measure: Relationship between the SPI during emergence time and the peak emergence delirium score
timeFrame: Observation from approximately 1 hour after the end of operation
Secondary outcomes:
measure: The sensitivity and specificity of the SPI in detecting the emergence delirium
timeFrame: Observation from approximately 1 hour after the end of operation
Other outcomes:
Locations:
city: Daegu
country: Korea, Republic of
facility: Daegu Catholic Medical Center
Study officials:
References:
Clinical trial NCT04136210: Registry Construction for Perioperative Data in Patients Undergoing Cardiovascular Surgery
Official title: Perioperative Clinical, Hemodynamic Data and Prognosis Assessment in Patients Who Undergo Cardiovascular Surgery; Registry Construction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiac Surgery
Anesthesia
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2019-10-23
Enrollment: 1568
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients undergoing cardiac or thoracic aortic surgery

Brief summary: The purpose of this registry is to obtain perioperative data in patients undergoing cardiac or thoracic aortic surgery and find out relations between the data and investigate several causes affecting postoperative complications.


Eligibility criteria: Inclusion Criteria:

* patients undergoing cardiac or thoracic aortic surgery

Exclusion Criteria:

* refused to participate

Primary outcomes:
measure: Baseline characteristics
timeFrame: Before surgery
measure: Preoperative data
timeFrame: Before surgery
measure: Intraoperative and postoperative data
timeFrame: During surgery and until 48 hours after surgery
measure: Operation data
timeFrame: During surgery
measure: Postoperative ICU data
timeFrame: 1 year after surgery
measure: Complications
timeFrame: 1 year after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References:
Clinical trial NCT00550810: Sutent Maintenance After Response to Taxotere
Official title: A Phase II Study of SU011248 for Maintenance Therapy in Hormone Refractory Prostate Cancer After First Line Chemotherapy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Prostate Cancer
Hormone Refractory
Keywords: Sutent
Lead sponsor: AHS Cancer Control Alberta
Sponsor class: OTHER
Collaborators: name: Pfizer
First posted: 2007-10-30
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The major goal is to determine whether the experimental agent has clinically promising activity that would merit progression to a formal phase III trial.

Patients with hormone refractory prostate cancer after docetaxel chemotherapy have limited treatment options and no systemic treatment has been proven to be effective. Because of its action, safety and simple administration SU011248 has potential for effectiveness in this disease setting. Promising activity in this study would provide the necessary proof-of-principle for a larger confirmatory study in this population, and potentially in earlier stages of this common disease.


Eligibility criteria: Inclusion Criteria:

* Histological or cytological diagnosis of adenocarcinoma of the prostate
* Metastatic or locally recurrent disease not curable with standard therapy
* ECOG performance status 0, 1 or 2
* Prior single agent docetaxel or docetaxel combination chemotherapy with a documented PSA or imaging response, and no objective evidence of disease progression at study enrolment

Exclusion Criteria:

* Patients with a history of other invasive cancer, except adequately treated non
* melanoma skin cancer.
* Patients with known brain metastases.
* History of allergic reactions attributed to compounds of similar chemical or biologic composition to SU011248.
* Other serious intercurrent illness or medical condition that might be aggravated by protocol treatment.

Primary outcomes:
measure: Progression Free Survival
timeFrame: 180 days without evidence of disease progression would be considered clinically worthy of further investigation
Secondary outcomes:
measure: -PSA Response -Toxicity
timeFrame: The secondary endpoint of PSA response will also be documented. PSA response is defined as a ≥50% fall in PSA (minimum of 5 µg/L) from baseline maintained for > 3 weeks and without evidence of disease progression otherwise.
Other outcomes:
Locations:
city: Calgary
country: Canada
facility: Tom Baker Cancer Centre
state: Alberta
city: Edmonton
country: Canada
facility: Cross Cancer Institute
state: Alberta
city: Vancouver
country: Canada
facility: Vancouver Cancer Centre
state: British Columbia
city: London
country: Canada
facility: London Health Sciences Centre
state: Ontario
Study officials:
affiliation: Tom Baker Cancer Board
name: Bernhard Eigl, M.D.
role: STUDY_CHAIR
References:
Clinical trial NCT03958110: Analysis of the Variation in Thickness of Per-papillary Retinal Optic Nerve Fibres in Professional Rugby Players
Official title: Analysis of the Variation in Thickness of Per-papillary Retinal Optic Nerve Fibres in Professional Rugby Players
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rugby Professionals
Concussion
Keywords: Retinophotography
OCT
Optical nerve
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
First posted: 2019-05-21
Enrollment: 49
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Professional rugby players

Brief summary: The main hypothesis is that exposure to repeated shocks is associated with a greater decrease in the thickness of optical nerve fibres.

In order to show a association between the occurrence of concussions (in number and severity) and the variation in the thickness of the retinal nerve fibre layer, all participating rugby players will have an ophthalmologic examination (OCT and (retinophotography) at the beginning and end of the Rugby season.


Eligibility criteria: Inclusion Criteria:

* Professional rugby player

Exclusion Criteria:

* impossibility to realise OCT

Primary outcomes:
measure: Average thickness difference of the RNFL on each eye in micrometers measured by OCT, between the beginning and the end of the season
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Fondation Opthalmologique A de Rothschild
Study officials:
References:
Clinical trial NCT06844110: Application of 68GA-labeled CD73 Targeting Probe PET/CT Imaging in the Diagnosis of Malignant Tumor
Official title: Application of 68GA-labeled CD73 Targeting Probe PET/CT Imaging in the Diagnosis of Malignant Tumor
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Tumor Immunity
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2025-02-25
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: 68Ga-DOTA-dPNE PET/CT imaging was performed on patients with malignant tumors to observe the binding of lesions with the tracer and evaluate the expression of CD73. At the same time, correlation analysis was performed combined with relevant clinical indicators to evaluate the efficacy of 68Ga-DOTA-dPNE in the diagnosis and guidance of malignant tumor patients, and predict the response of targeted therapy.


Eligibility criteria: Inclusion Criteria:

* 1: Age: ≥18 years, expected survival ≥12 weeks 2: Without radiotherapy and chemotherapy, surgery or biopsy is feasible to obtain pathological diagnosis 3: Standard Solid Tumor Response Evaluation Criteria (RECIST) version 1.1 with at least one measurable target lesion 4: Obtain written informed consent and be able to follow up

Exclusion Criteria:

- 1: Severe liver and kidney dysfunction. 2: Women who are planning to conceive, pregnant, or breastfeeding, as well as those planning to have children during the study period, are not eligible to participate in this research. Women of childbearing potential must use effective contraception throughout the course of the study.

3: Individuals unable to lie flat for thirty minutes. 4: Suffers from claustrophobia or other mental illnesses 5: Researchers believe that the subject has other conditions that make them unsuitable for inclusion in this study 6: Refuses to join this clinical study

Primary outcomes:
measure: Lesion SUV value
timeFrame: After the completion of the PET scan
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00221910: Use of Ultrasound in Lower Extremity Blocks.
Official title: Does Ultrasound Guidance Improve the Success of Sciatic Nerve Block at the Popliteal Fossa? A Prospective, Randomized, Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Regional Anesthesia
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
Collaborators: name: University of Toronto
First posted: 2005-09-22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Nerve "freezing" injections of the leg are very useful in providing anesthesia and pain relief for knee and ankle surgery. However, current nerve "freezing" techniques are "blind". As a result, they are not always successful and may cause complications, albeit infrequent.

The objective of the current study is to determine any advantage in performing these "freezing" injections under direct ultrasound guidance, to "visualize" the nerves. We feel that by developing this technique, it will allow us to perform these procedures with greater success and fewer complications.

Detailed description: This study is a randomised controlled trial. Its objective is to compare results and complications between two techniques of nerve localisation for nerve blocks of the lower limb. We have developed a real-time, image guided approach to nerve blocks of the lower extremities in three locations: the femoral nerve in the groin and the sciatic nerve in the buttock and/or popliteal fossa. We have used ultrasound imaging to locate and asess the nerves of the lower extremities and to use it as a real-time guidance for performance of lower extremity blocks in patients undergoing orthopaedic procedures. The results of our previous study will be presented as a case series reporting anatomical appearance of the nerves studied, time for block performance and success rates. In this study we aim to compare these parambeters between standard and ultrasound techniques of lower extremity block, to show any advantage.

Eligibility criteria: Inclusion Criteria:

* English-speaking
* ASA physical status I-III
* 18-85 years of age, inclusive
* 50-110 kg, inclusive
* 150 cm of height or grater
* Scheduled for elective foot or ankle surgery

Exclusion Criteria:

* Contraindications to sciatic nerve block (e.g., allergy to local anesthetics, coagulopathy, malignancy or infection in the popliteal area)
* Significant peripheral neuropathy or neurologic disorder affecting the lower extremity
* Pregnancy
* Contraindications to, allergies to, and/or past adverse reactions to local anesthetics
* History of alcohol or drug dependency/abuse

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: University Health Network
state: Ontario
Study officials:
affiliation: University Health Network, Toronto
name: Anahi Perlas, MD
role: PRINCIPAL_INVESTIGATOR
References: