Clinical trial NCT06077864: A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
Official title: A Phase 3, Randomised, Double-blind, Parallel-group, Event-driven, Cardiovascular Safety Study With BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity With Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, and/or at Least Two Weight-related Complications or Risk Factors for CVD
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Obesity
Lead sponsor: Boehringer Ingelheim
Sponsor class: INDUSTRY
First posted: 2023-10-11
Enrollment: 5550
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is open to adults who are at least 18 years old and have a body mass index (BMI)bof 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease. People who have at least 2 health problems related to their weight or risks of cardiovascular disease can participate. Participants must have previously tried to lose weight by changing their diet.

The purpose of this study is to find out whether people with overweight or obesity who take a medicine called survodutide (BI 456906) are less or more likely to develop serious cardiovascular problems. It also aims to find out whether health parameters like blood pressure improve. Overweight and obesity are linked to cardiovascular disease. Survodutide is a medicine that is developed to help people with obesity or overweight to lose weight.

Participants are divided into 3 groups of almost equal size. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under the skin once a week. All participants also receive counselling on diet and physical activity.

Participants are in the study for up to 2 years and 3 months. During this time, it is planned that participants visit the study site up to 21 times and attend remote visits by video calls. During these visits, the doctors check participants' cardiovascular and overall health. The results are compared between survodutide and placebo groups. The study staff also takes note of any unwanted effects.


Eligibility criteria: Inclusion Criteria:

1. Male or female, age ≥18 years at the time of signing informed consent, and at least the legal age of consent in countries where it is \>18 years.
2. Body mass index (BMI) ≥27 kg/m2 at screening with established cardiovascular disease (CVD) and/or at least 2 weight-related complications or risk factors for CVD OR BMI ≥30 kg/m2 at screening with established CVD or chronic kidney disease (CKD), and/or at least 2 weight-related complications or risk factors for CVD.

Further inclusion criteria apply.

Exclusion criteria:

1. Previous treatment with glucagon-like peptide-1 receptor (GLP-1R) agonists within 3 months before screening.
2. Type 1 diabetes.
3. Less than 3 months between the last dose of GLP-1R agonists and GLP-1R agonist/insulin/glucose-dependent insulinotropic polypeptide (GIP) combinations and screening.
4. Known clinically significant gastric emptying abnormality (e.g., severe diabetic gastroparesis or gastric outlet obstruction).

Further exclusion criteria apply.

Primary outcomes:
measure: Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, non-fatal MI, ischaemia related coronary revascularisation, or HFE (to demonstrate non-inferiority)
timeFrame: up to Week 114
Secondary outcomes:
measure: Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, or non-fatal MI (3-point major adverse cardiac event (3P-MACE)) (to demonstrate non-inferiority)
timeFrame: up to Week 114
measure: Absolute change in systolic blood pressure (SBP) (mmHg) from baseline to Week 72
timeFrame: Baseline and at Week 72
measure: Absolute change in waist circumference (cm) from baseline to Week 72
timeFrame: Baseline and at Week 72
measure: Absolute change in Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ-TSS) from baseline to Week 72 in trial participants with HF at baseline
timeFrame: At Baseline and at Week 72
measure: Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, non-fatal MI, ischaemia related coronary revascularisation, or HFE (to demonstrate superiority)
timeFrame: up to Week 114
measure: Percentage change in body weight from baseline to Week 72
timeFrame: Baseline and at Week 72
measure: Absolute change in diastolic blood pressure (DBP) (mmHg) from baseline to Week 72
timeFrame: Baseline and at Week 72
measure: Absolute change in aspartate aminotransferase (AST) (U/L) from baseline to Week 72
timeFrame: Baseline and at Week 72
measure: Absolute change in alanine aminotransferase (ALT) (U/L) from baseline to Week 72
timeFrame: Baseline and at Week 72
measure: Absolute change in glycosylated haemoglobin A1c (HbA1c) (mmol/mol) from baseline to Week 72 in trial participants with type 2 diabetes mellitus (T2DM)
timeFrame: Baseline and at Week 72
measure: Absolute change in HbA1c (%) from baseline to Week 72 in trial participants with T2DM
timeFrame: Baseline and at Week 72
measure: Time to onset of T2DM in trial participants without T2DM at baseline
timeFrame: up to Week 114
measure: Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, non-fatal MI, or ischaemia related coronary revascularisation (4-point major adverse cardiac event (4P-MACE))
timeFrame: up to Week 114
measure: Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, non-fatal MI, or HFE (3P-MACE+ HFE)
timeFrame: up to Week 114
measure: Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, or non-fatal MI (3P-MACE)
timeFrame: up to Week 114
measure: Time to first occurrence of adjudicated CV death or adjudicated HFE
timeFrame: up to Week 114
measure: Time to first occurrence of adjudicated CV death or adjudicated HHF
timeFrame: up to Week 114
measure: Time to first occurrence of adjudicated HFE
timeFrame: up to Week 114
measure: Time to adjudicated CV death
timeFrame: up to Week 114
measure: Time to all-cause mortality
timeFrame: up to Week 114
measure: Time to first occurrence of adjudicated non-fatal MI
timeFrame: up to Week 114
measure: Time to first occurrence of adjudicated non-fatal stroke
timeFrame: up to Week 114
measure: Time to first occurrence of adjudicated ischaemia related coronary revascularisation
timeFrame: up to Week 114
measure: Achievement of body weight reduction ≥5% from baseline to Week 72
timeFrame: Baseline and at Week 72
measure: Achievement of body weight reduction ≥10% from baseline to Week 72
timeFrame: Baseline and at Week 72
measure: Achievement of body weight reduction ≥15% from baseline to Week 72
timeFrame: Baseline and at Week 72
measure: A composite of death, number of adjudicated HFEs, time to first adjudicated HFE and change from baseline in KCCQ-TSS at 72 weeks assessed by the win ratio in trial participants with HF at baseline
timeFrame: At baseline and at 72 Weeks
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Cardiology P.C.
state: Alabama
city: Daphne
country: United States
facility: AMR Daphne
state: Alabama
city: Mobile
country: United States
facility: AMR Mobile
state: Alabama
city: Mobile
country: United States
facility: Mobile Heart Specialists, PC
state: Alabama
city: Chandler
country: United States
facility: The Institute for Liver Health, LLC
state: Arizona
city: Sun City West
country: United States
facility: Clinical Research Institute of Arizona, LLC
state: Arizona
city: Tempe
country: United States
facility: AMR Phoenix
state: Arizona
city: Tucson
country: United States
facility: Arizona Liver Health-Tucson-67516
state: Arizona
city: Yuma
country: United States
facility: Yuma Clinical Trials
state: Arizona
city: Little Rock
country: United States
facility: Lynn Institute of the Ozarks
state: Arkansas
city: Huntington Park
country: United States
facility: Velocity Clinical Research-Huntington Park-68988
state: California
city: La Mesa
country: United States
facility: Velocity Clinical Research-La Mesa-69117
state: California
city: Los Angeles
country: United States
facility: Velocity Clinical Research, Westlake
state: California
city: Montclair
country: United States
facility: Catalina Research Institute, LLC-Montclair-69754
state: California
city: Northridge
country: United States
facility: Valley Clinical Trials, Inc.
state: California
city: San Ramon
country: United States
facility: NorCal Endocrinology and Internal Medicine
state: California
city: Santa Ana
country: United States
facility: Velocity Clinical Research-Santa Ana-68902
state: California
city: Santa Rosa
country: United States
facility: NorthBay Clinical Research, LLC
state: California
city: Van Nuys
country: United States
facility: Velocity Clinical Research-Van Nuys-70286
state: California
city: Colorado Springs
country: United States
facility: Peak Gastroenterology Associates-Colorado Springs-62256
state: Colorado
city: Bridgeport
country: United States
facility: Bridgeport Hospital
state: Connecticut
city: Hamden
country: United States
facility: CMR of Greater New Haven, LLC
state: Connecticut
city: Waterbury
country: United States
facility: Chase Medical Research, LLC
state: Connecticut
city: Boca Raton
country: United States
facility: Proactive Clinical Research
state: Florida
city: Boca Raton
country: United States
facility: Excel Medical Clinical Trials
state: Florida
city: Clearwater
country: United States
facility: Clinical Research of West Florida, Inc.
state: Florida
city: Crystal River
country: United States
facility: Nature Coast Clinical Research-Crystal River-62355
state: Florida
city: Cutler Bay
country: United States
facility: Beautiful Minds Clinical Research Center
state: Florida
city: Fort Myers
country: United States
facility: AMR Fort Myers
state: Florida
city: Fort Myers
country: United States
facility: Covenant Metabolic Specialists, LLC-Fort Myers-69019
state: Florida
city: Hallandale Beach
country: United States
facility: Velocity Clinical Research-Hallandale Beach-67888
state: Florida
city: Jacksonville
country: United States
facility: Westside Center for Clinical Research
state: Florida
city: Leesburg
country: United States
facility: Clinical Site Partners LLC
state: Florida
city: Miami
country: United States
facility: Suncoast Research Group
state: Florida
city: Miami
country: United States
facility: Verus Clinical Research Corporation
state: Florida
city: Miami
country: United States
facility: Clinical Trial Services, Corp
state: Florida
city: Pinellas Park
country: United States
facility: Synexus-Pinellas Park-69294
state: Florida
city: Saint Augustine
country: United States
facility: East Coast Institute for Research, LLC-Saint Augustine-63032
state: Florida
city: Sweetwater
country: United States
facility: Lenus Research & Medical Group
state: Florida
city: Tampa
country: United States
facility: Santos Research Center, Corp.
state: Florida
city: University Park
country: United States
facility: Covenant Metabolic Specialists, LLC-Sarasota-68343
state: Florida
city: Albany
country: United States
facility: Javara-Albany-67356
state: Georgia
city: Columbus
country: United States
facility: Centricity Research-Columbus-68877
state: Georgia
city: Fayetteville
country: United States
facility: Javara-Fayetteville-67354
state: Georgia
city: Johns Creek
country: United States
facility: NSC Research Inc
state: Georgia
city: Macon
country: United States
facility: East Coast Institute for Research, LLC-Macon-68109
state: Georgia
city: Marietta
country: United States
facility: Urban Family Practice Associates, PC
state: Georgia
city: Savannah
country: United States
facility: Javara-Savannah-67450
state: Georgia
city: Arlington Heights
country: United States
facility: Northwest Heart Clinical Research, LLC
state: Illinois
city: Chicago
country: United States
facility: Cedar Crosse Research Center
state: Illinois
city: Chicago
country: United States
facility: Research by Design, LLC
state: Illinois
city: Evansville
country: United States
facility: Medisphere Medical Research Center
state: Indiana
city: Ames
country: United States
facility: McFarland Clinic PC
state: Iowa
city: West Des Moines
country: United States
facility: Iowa Diabetes and Endocrinology Research Center
state: Iowa
city: El Dorado
country: United States
facility: AMR El Dorado
state: Kansas
city: Newton
country: United States
facility: AMR Newton
state: Kansas
city: Wichita
country: United States
facility: AMR Wichita East
state: Kansas
city: Owensboro
country: United States
facility: Research Integrity, LLC
state: Kentucky
city: Bossier City
country: United States
facility: Grace Research, LLC-Bossier City-51040
state: Louisiana
city: Hammond
country: United States
facility: Heart Clinic of Hammond
state: Louisiana
city: Marrero
country: United States
facility: Tandem Clinical Research
state: Louisiana
city: New Orleans
country: United States
facility: AMR New Orleans
state: Louisiana
city: Shreveport
country: United States
facility: Grace Research, LLC-Shreveport-64616
state: Louisiana
city: Annapolis
country: United States
facility: Javara Inc.-Annapolis-68997
state: Maryland
city: Baltimore
country: United States
facility: Ascension Saint Agnes Heart Care
state: Maryland
city: Oxon Hill
country: United States
facility: MD Medical Research
state: Maryland
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center
state: Massachusetts
city: Flint
country: United States
facility: Elite Research Center, LLC
state: Michigan
city: Grand Rapids
country: United States
facility: Healthy Heart Cardiology
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic, Rochester
state: Minnesota
city: Biloxi
country: United States
facility: National Diabetes and Obesity Research Institute
state: Mississippi
city: Fayette
country: United States
facility: Prime Health and Wellness
state: Mississippi
city: Gulfport
country: United States
facility: Velocity Clinical Research-Gulfport-68930
state: Mississippi
city: Kansas City
country: United States
facility: Clinical Research Consultants, LLC
state: Missouri
city: Kansas City
country: United States
facility: AMR Kansas City
state: Missouri
city: Saint Louis
country: United States
facility: Sundance Clinical Research, LLC
state: Missouri
city: Springfield
country: United States
facility: Clinvest Research LLC
state: Missouri
city: Butte
country: United States
facility: Mercury Street Medical
state: Montana
city: Elkhorn
country: United States
facility: Skyline Medical Center
state: Nebraska
city: Fremont
country: United States
facility: Methodist Physicians Clinic
state: Nebraska
city: Las Vegas
country: United States
facility: AMR Las Vegas
state: Nevada
city: Bridgewater
country: United States
facility: Advanced Heart Care, LLC
state: New Jersey
city: Linden
country: United States
facility: NJ Heart LLC
state: New Jersey
city: Warren
country: United States
facility: IMA Clinical Research-Warren-69742
state: New Jersey
city: Albuquerque
country: United States
facility: IMA Clinical Research Albuquerque
state: New Mexico
city: Binghamton
country: United States
facility: Meridian Clinical Research, LLC-Binghamton-69645
state: New York
city: New York
country: United States
facility: Synexus Clinical Research US, Inc.
state: New York
city: Saratoga Springs
country: United States
facility: Saratoga Clinical Research, LLC
state: New York
city: Cary
country: United States
facility: Accellacare of Cary
state: North Carolina
city: Chapel Hill
country: United States
facility: The University of North Carolina at Chapel Hill
state: North Carolina
city: Charlotte
country: United States
facility: Javara-Charlotte-67884
state: North Carolina
city: Mooresville
country: United States
facility: Accellacare-Mooresville-69123
state: North Carolina
city: New Bern
country: United States
facility: Lucas Research
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest University Health Sciences-Winston-Salem-69719
state: North Carolina
city: Cincinnati
country: United States
facility: Velocity Clinical Research-Cincinnati-69044
state: Ohio
city: Columbus
country: United States
facility: Synexus Clinical Research-Columbus-69427
state: Ohio
city: Columbus
country: United States
facility: Centricity Research-Columbus-68879
state: Ohio
city: Dublin
country: United States
facility: Aventiv Research Inc.-Dublin-62009
state: Ohio
city: Westlake
country: United States
facility: Clinical Research Institute of Ohio, LLC
state: Ohio
city: Edmond
country: United States
facility: Tekton Research-Edmond-68875
state: Oklahoma
city: Norman
country: United States
facility: AMR Norman
state: Oklahoma
city: Norman
country: United States
facility: Lynn Institute of Norman
state: Oklahoma
city: Oklahoma City
country: United States
facility: Lynn Health Science Institute
state: Oklahoma
city: Oklahoma City
country: United States
facility: South Oklahoma Heart Research Group
state: Oklahoma
city: Medford
country: United States
facility: Velocity Clinical Research-Medford-69053
state: Oregon
city: Beaver
country: United States
facility: Heritage Valley Medical Group
state: Pennsylvania
city: Camp Hill
country: United States
facility: Capital Area Research, LLC
state: Pennsylvania
city: Philadelphia
country: United States
facility: Tristar Clinical Investigations PC
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Preferred Primary Care Physicians-Pittsburgh-63932
state: Pennsylvania
city: Uniontown
country: United States
facility: Preferred Primary Care Physicians-Uniontown-69137
state: Pennsylvania
city: East Greenwich
country: United States
facility: Velocity Clinical Research-East Greenwich-68873
state: Rhode Island
city: Anderson
country: United States
facility: Synexus - Anderson
state: South Carolina
city: Anderson
country: United States
facility: Velocity Clinical Research-Anderson-69093
state: South Carolina
city: Gaffney
country: United States
facility: Velocity Clinical Research-Gaffney-69046
state: South Carolina
city: Greenville
country: United States
facility: Tribe Clinical Research LLC
state: South Carolina
city: Greenville
country: United States
facility: Velocity Clinical Research-Greenville-69045
state: South Carolina
city: North Charleston
country: United States
facility: Coastal Carolina Research Center
state: South Carolina
city: Union
country: United States
facility: Velocity Clinical Research-Union-68888
state: South Carolina
city: Bristol
country: United States
facility: Internal Medicine and Pediatric Associates of Bristol, PC
state: Tennessee
city: Chattanooga
country: United States
facility: Chattanooga Research & Medicine, PLLC
state: Tennessee
city: Knoxville
country: United States
facility: Alliance for Multispecialty Research, LLC-Knoxville-69693
state: Tennessee
city: Knoxville
country: United States
facility: Accellacare of Knoxville-Knoxville-69135
state: Tennessee
city: Knoxville
country: United States
facility: Accellacare of Knoxville-Knoxville-69714
state: Tennessee
city: Memphis
country: United States
facility: Clinical Neuroscience Solutions, Inc-Memphis-65988
state: Tennessee
city: Nashville
country: United States
facility: Clinical Research Associates, Inc
state: Tennessee
city: Amarillo
country: United States
facility: Amarillo Medical Specialists
state: Texas
city: Austin
country: United States
facility: Velocity Clinical Research, Austin
state: Texas
city: Brownsville
country: United States
facility: Headlands Research
state: Texas
city: Conroe
country: United States
facility: Privia Medical Group Gulf Coast, PLLC
state: Texas
city: Dallas
country: United States
facility: Velocity Clinical Research-Dallas-69170
state: Texas
city: Fort Worth
country: United States
facility: Texas Health Care PLLC
state: Texas
city: Houston
country: United States
facility: Houston Research Institute
state: Texas
city: San Antonio
country: United States
facility: IMA Clinical Research San Antonio
state: Texas
city: San Antonio
country: United States
facility: Tekton Research-San Antonio-68916
state: Texas
city: San Marcos
country: United States
facility: Javara Inc. and Privia Medical Group Gulf Coast, PLLC
state: Texas
city: Stephenville
country: United States
facility: Javara Inc.-Stephenville-68996
state: Texas
city: Tomball
country: United States
facility: DM Clinical Research - Martin Diagnostic Clinic
state: Texas
city: Waco
country: United States
facility: Velocity Clinical Research, Waco
state: Texas
city: Draper
country: United States
facility: Physicians' Research Options. LLC
state: Utah
city: Layton
country: United States
facility: Alliance for Multispecialty Research, LLC-Layton-69691
state: Utah
city: Saint George
country: United States
facility: Chrysalis Clinical Research
state: Utah
city: Salt Lake City
country: United States
facility: Synexus Clinical Research-Salt Lake City-69293
state: Utah
city: West Jordan
country: United States
facility: Velocity Clinical Research-West Jordan-69043
state: Utah
city: Arlington
country: United States
facility: Washington Center for Weight Management and Research, Inc.
state: Virginia
city: Falls Church
country: United States
facility: Seven Corners Medical Center
state: Virginia
city: Norfolk
country: United States
facility: Eastern Virginia Medical School
state: Virginia
city: Winchester
country: United States
facility: Selma Medical Associates, Winchester
state: Virginia
city: Seattle
country: United States
facility: Velocity Clinical Research-Seattle-69881
state: Washington
city: Spokane
country: United States
facility: Velocity Clinical Research-Spokane-69716
state: Washington
city: Kenosha
country: United States
facility: Clinical Investigation Specialists, Inc.-Kenosha-69111
state: Wisconsin
city: Wauwatosa
country: United States
facility: Allegiance Research Specialists
state: Wisconsin
city: Caba
country: Argentina
facility: CEDIC - Centro de Investigacion Clinica
city: Caba
country: Argentina
facility: Mautalen- Salud e Investigacion
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Centro de Investigaciones Metabolicas (CINME)-Ciudad Autonoma Buenos Aires-41221
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Centro Medico Dra Laura Maffei
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Glenny Corp. S.A. Bioclinica Argentina
city: Ciudad Autonoma de Bs As
country: Argentina
facility: Centro Medico Viamonte
city: Ciudad Autonoma de Bs As
country: Argentina
facility: Sanatorio Güemes
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Consultorio de Investigacion Clinica EMO SRL
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Centro de Investigaciones y Prevencion Cardiovascular CIPREC
city: Cordoba
country: Argentina
facility: CIDIM - Centro Integral de Diagnostico por Imagenes Marchegiani
city: Mar del Plata
country: Argentina
facility: Centro de Investigaciones Medicas Mar del Plata
city: Mar del Plata
country: Argentina
facility: Instituto de Investigaciones Clinicas Mar del Plata
city: Parque Velez Sarfield
country: Argentina
facility: Hospital Privado - Centro Medico de Cordoba S.A.
city: Villa Luro
country: Argentina
facility: CEMEDIC - Centro de Especialidades Medicas
city: Camperdown
country: Australia
facility: The Boden Initiative
state: New South Wales
city: Kotara
country: Australia
facility: Novatrials
state: New South Wales
city: St Leonards
country: Australia
facility: Royal North Shore Hospital-St Leonards-66471
state: New South Wales
city: Taringa
country: Australia
facility: AusTrials - Taringa
state: Queensland
city: Wellers Hill
country: Australia
facility: AusTrials
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
state: South Australia
city: Leabrook
country: Australia
facility: Advara Heart Care-Leabrook-69072
state: South Australia
city: Clayton
country: Australia
facility: Victorian Heart Hospital
state: Victoria
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Joondalup
country: Australia
facility: Advara Heart Care-Joondalup-69073
state: Western Australia
city: Graz
country: Austria
facility: Medical University of Graz State Hospital - University Hospital Graz
city: Innsbruck
country: Austria
facility: Medical University of Innsbruck
city: Linz
country: Austria
facility: Convent Hospital Barmherzige Brüder
city: Salzburg
country: Austria
facility: LKH Salzburg University Hospital
city: Stockerau
country: Austria
facility: Hospital Stockerau
city: Vienna
country: Austria
facility: Clinic Landstrasse
city: Vienna
country: Austria
facility: Private Practice - Dr. Ursula Hanusch-Enserer
city: Vienna
country: Austria
facility: AKH - Medical University of Vienna
city: Brugge
country: Belgium
facility: AZ Sint-Jan Brugge
city: Edegem
country: Belgium
facility: Edegem - UNIV UZ Antwerpen
city: Leuven
country: Belgium
facility: UZ Leuven
city: Belém
country: Brazil
facility: Hospital Universitário João de Barros Barreto
city: Brasilia
country: Brazil
facility: Chronos Pesquisa Clinica
city: Brasília
country: Brazil
facility: L2IP -Instituto de Pesquisas Clínicas Ltda.
city: Curitiba
country: Brazil
facility: Cline Research Center
city: Fortaleza
country: Brazil
facility: Instituto de Estudos e Pesquisas Clínicas IEP-CE
city: Porto Alegre
country: Brazil
facility: Universidade Federal do Rio Grande do Sul
city: Rio de Janeiro
country: Brazil
facility: Instituto Brasil de Pesquisa Clinica (IBPClin)
city: Sao Paulo
country: Brazil
facility: Irmandade da Santa Casa de Misericórdia de São Paulo - IPEC - Instituto de Pesquisa Clínica
city: Sao Paulo
country: Brazil
facility: BR Trials
city: Sao Paulo
country: Brazil
facility: CEPIC - Centro Paulista de Investigacao Clinica
city: São José dos Campos
country: Brazil
facility: ISPEM - Instituto São Jose dos Campos em Pesquisas Medicas
city: São Paulo
country: Brazil
facility: Cpquali Pesquisa Clinica Ltda
city: São Paulo
country: Brazil
facility: Hospital das Clinicas da FMUSP
city: Byala
country: Bulgaria
facility: MHAT "Yuliya Vrevska" EOOD, Byala
city: Dobrich
country: Bulgaria
facility: MHAT - Dobrich, AD
city: Dupnitsa
country: Bulgaria
facility: Multy profile hospital for active treatment Sv.Ivan Rilski
city: Plovdiv
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Trimontsium OOD
city: Plovdiv
country: Bulgaria
facility: MHAT "St. Caridad"
city: Sliven
country: Bulgaria
facility: Multy Profile Hospital for active treatment Hadzhi Dimirar
city: Sofia
country: Bulgaria
facility: Diagnostic & Consultancy Center "Ascendent", Sofia
city: Sofia
country: Bulgaria
facility: Diagnostic Consultative Center Alexandrovska
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatement "Alexandrovska" EAD
city: Sofia
country: Bulgaria
facility: MHAT "Tsaritsa Yoanna-ISUL" Clinic of Cardiology, Sofia
city: Sofia
country: Bulgaria
facility: Medical Center Synexus Sofia EOOD
city: Yambol
country: Bulgaria
facility: Medical Center Berbatov
city: Yambol
country: Bulgaria
facility: MHAT St Panteleimon
city: Calgary
country: Canada
facility: Richmond Road Diagnostic & Treatment Centre
state: Alberta
city: Calgary
country: Canada
facility: C-ENDO Diabetes & Endocrinology Clinic
state: Alberta
city: Red Deer
country: Canada
facility: CARe Clinic (Red Deer)
state: Alberta
city: Surrey
country: Canada
facility: SMH Cardiology Clinical Trials Inc.
state: British Columbia
city: Victoria
country: Canada
facility: Victoria Heart Institute Foundation
state: British Columbia
city: Winnipeg
country: Canada
facility: Winnipeg Clinic
state: Manitoba
city: Halifax
country: Canada
facility: QEII Health Sciences Centre
state: Nova Scotia
city: Brampton
country: Canada
facility: Centricity Research (Brampton)
state: Ontario
city: Burlington
country: Canada
facility: Wharton Medical Clinic (Burlington)
state: Ontario
city: Cambridge
country: Canada
facility: Cambridge Cardiac Care Centre
state: Ontario
city: Etobicoke
country: Canada
facility: Centricity Research (Etobicoke)
state: Ontario
city: Hamilton
country: Canada
facility: Premier Clinical Trial Network
state: Ontario
city: London
country: Canada
facility: Western Centre for Public Health & Family Medicine (LHRI)
state: Ontario
city: Oshawa
country: Canada
facility: Centricity Research (Oshawa)
state: Ontario
city: Sarnia
country: Canada
facility: Bluewater Clinical Research
state: Ontario
city: Toronto
country: Canada
facility: Canadian Phase Onward Inc.
state: Ontario
city: Toronto
country: Canada
facility: Centricity Research (Bayview)
state: Ontario
city: Toronto
country: Canada
facility: Diabetes Heart Research Centre
state: Ontario
city: Waterloo
country: Canada
facility: Clinical Research Solutions Inc. (Waterloo)
state: Ontario
city: Chicoutimi
country: Canada
facility: Ecogene-21
state: Quebec
city: Montreal
country: Canada
facility: Montreal Heart Institute
state: Quebec
city: Montreal
country: Canada
facility: Montreal General Hospital - McGill University Health Centre
state: Quebec
city: Québec
country: Canada
facility: Recherche Clinique Sigma Inc.
state: Quebec
city: Terrebonne
country: Canada
facility: Centre de Medecine Metabolique de Lanaudiere
state: Quebec
city: Trois-Rivieres
country: Canada
facility: Diex Recherche (Trois-Rivieres)
state: Quebec
city: Beijing
country: China
facility: Beijing Chao-Yang Hospital
city: Beijing
country: China
facility: Peking University First Hospital
city: Beijing
country: China
facility: Beijing Pinggu Hospital
city: Changchun
country: China
facility: The Second Hospital of Jilin University
city: Changzhou
country: China
facility: Changzhou Second People's Hospital
city: Chongqing
country: China
facility: Second Affiliated Hospital Chongqing Medical University
city: Hangzhou
country: China
facility: Hangzhou First People's Hospital
city: Harbin
country: China
facility: Forth Clinical Hospital of Harbin Medical University
city: Hengyang
country: China
facility: The First Affiliated Hospital of University of South China
city: Huai'an
country: China
facility: Huai'an first people's hospital
city: Huzhou
country: China
facility: Huzhou Central Hospital
city: Jinan
country: China
facility: Center Hospital of Jinan
city: Lishui
country: China
facility: Lishui Municipal Central Hospital
city: Luoyang
country: China
facility: The First Affiliated Hospital of Henan University of Science and Technology
city: Nanchang
country: China
facility: Nanchang Third Hospital
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital
city: Nanjing
country: China
facility: Zhongda Hospital Southeast University
city: Nanjing
country: China
facility: The Second Affiliated Hospital of Nanjing Medical University
city: Nanjing
country: China
facility: Nanjing Jiangning Hospital
city: Nanyang
country: China
facility: The First Affiliated Hospital of Nanyang Medical College
city: Ningbo
country: China
facility: The First Affiliated Hospital of Ningbo University
city: Qinhuangdao
country: China
facility: First Hospital of Qinhuangdao
city: Shanghai
country: China
facility: Zhongshan Hospital Affiliated to Fudan University
city: Shanghai
country: China
facility: Tongren hospital, Shanghai Jiaotong University School of Medicine
city: Shanghai
country: China
facility: Shanghai Municipal Hospital of Traditional Chinese Medicine
city: Shanghai
country: China
facility: Shanghai Fifth People's Hospital affiliated to Fudan University
city: Shanghai
country: China
facility: Shanghai Pudong New District People's Hospital
city: Shijiazhuang
country: China
facility: The Second Hospital of Hebei Medical University
city: Suzhou
country: China
facility: Suzhou Science & Technology Town Hospital
city: Xi'an
country: China
facility: Shaanxi Provincial People's Hospital
city: Xi'an
country: China
facility: First Affiliated Hospital of Xi'an JiaoTong University
city: Xi'an
country: China
facility: The First Affiliated Hospital of Xi'an Medical University
city: Xianyang
country: China
facility: Xianyang Hospital of Yan'an University
city: Zhenjiang
country: China
facility: Affiliated Hospital of Jiangsu University
city: Brno
country: Czechia
facility: University Hospital at St. Anna
city: Havirov
country: Czechia
facility: DIKa centrum s.r.o.
city: Karlovy Vary
country: Czechia
facility: Center for Osteoporosis Therapy
city: Nachod
country: Czechia
facility: Internal and Diabetes Clinic
city: Olomouc
country: Czechia
facility: PreventaMed, s.r.o.
city: Ostrava-Poruba
country: Czechia
facility: University Hospital Ostrava
city: Plzen
country: Czechia
facility: Internal ambulance Dialine s.r.o.
city: Prague 2
country: Czechia
facility: General Faculty Hospital, Prague
city: Prague
country: Czechia
facility: Synexus Czech s.r.o.
city: Prague
country: Czechia
facility: OB Klinika
city: Prague
country: Czechia
facility: Institute for Clinical and Experimental Medicine-Prague-66083
city: Praha 8
country: Czechia
facility: ResTrial s.r.o.
city: Aarhus N
country: Denmark
facility: Aarhus University Hospital
city: Copenhagen
country: Denmark
facility: Copenhagen University Hospital, Rigshospitalet
city: Herlev
country: Denmark
facility: Herlev and Gentofte Hospital
city: Herning
country: Denmark
facility: Regionshospitalet Gødstrup
city: Hvidovre
country: Denmark
facility: Hvidovre Hospital
city: Helsinki
country: Finland
facility: CRST Helsinki Oy
city: Jyväskylä
country: Finland
facility: StudyCor Oy
city: Pori
country: Finland
facility: Terveystalo Pori Lääkäritalo
city: Tampere
country: Finland
facility: Tampere University Hospital
city: Turku
country: Finland
facility: Terveystalo Pulssi, Turku
city: Aachen
country: Germany
facility: Universitätsklinikum Aachen, AöR
city: Berlin
country: Germany
facility: Velocity Clinical Research Germany GmbH-Berlin-69769
city: Berlin
country: Germany
facility: DRK Kliniken Berlin Köpenick
city: Berlin
country: Germany
facility: Synexus Clinical Research GmbH-Berlin-26285
city: Düsseldorf
country: Germany
facility: Universitätsklinikum Düsseldorf
city: Erlangen
country: Germany
facility: Universitätsklinikum Erlangen
city: Frankfurt
country: Germany
facility: Synexus Clinical Research GmbH-Frankfurt-56626
city: Freiburg
country: Germany
facility: Universitätsklinikum Freiburg
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
city: Heidelberg
country: Germany
facility: St. Josefskrankenhaus Heidelberg
city: Homburg
country: Germany
facility: Universität des Saarlandes
city: Kiel
country: Germany
facility: Universitätsklinikum Schleswig-Holstein, Campus Kiel
city: Köln
country: Germany
facility: Universitätsklinikum Köln (AöR)
city: Leipzig
country: Germany
facility: Synexus Clinical Research GmbH-Leipzig-57914
city: Mainz
country: Germany
facility: Universitätsmedizin der Johannes Gutenberg-Universität Mainz
city: Münster
country: Germany
facility: Westfälische Wilhelms-Universität Münster
city: Pohlheim
country: Germany
facility: CEDA Research GBR
city: Tübingen
country: Germany
facility: Universitätsklinikum Tübingen
city: Athens
country: Greece
facility: General Hospital of Athens "Laiko"
city: Haidari-Athens
country: Greece
facility: Attikon University Hospital
city: Heraklion, Crete
country: Greece
facility: University General Hospital of Heraklion
city: Ioannina
country: Greece
facility: Univ. Gen. Hosp. of Ioannina
city: Larissa
country: Greece
facility: General University Hospital of Larissa
city: P. Faliro
country: Greece
facility: Iatriko of Athens Group/ Iatriko of P. Faliro
city: Psychiko
country: Greece
facility: Iatriko Psychikou
city: Thessaloniki
country: Greece
facility: Gen. Hosp. of Thessaloniki "Hippokation", Department of Endocrinology
city: Thessaloniki
country: Greece
facility: University General Hospital of Thessaloniki AHEPA
city: Hong Kong
country: Hong Kong
facility: Prince of Wales Hospital-Hong Kong-20715
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
city: Hong Kong
country: Hong Kong
facility: Tung Wah Hospital
city: Baja
country: Hungary
facility: Lausmed Kft. Outpatient Unit of Internal Medicine
city: Budapest
country: Hungary
facility: Obuda Health Center
city: Budapest
country: Hungary
facility: Synexus Hungary Healthcare Service Ltd.
city: Budapest
country: Hungary
facility: Central Hospital of Northern Pest - Military Hospital
city: Budapest
country: Hungary
facility: Bajcsy-Zsilinszky Hospital and Clinic
city: Budapest
country: Hungary
facility: Semmelweis University
city: Debrecen
country: Hungary
facility: University Debrecen Hospital
city: Godollo
country: Hungary
facility: Erzsebet Nursing Home
city: Gyula
country: Hungary
facility: Synexus Hungary Healthcare Service Ltd
city: Hatvan
country: Hungary
facility: BKS Research Ltd
city: Kalocsa
country: Hungary
facility: Studium Egeszseghaz Kft.
city: Kaposvar
country: Hungary
facility: Somogy County Kaposi Mor Teaching Hospital
city: Zalaegerszeg
country: Hungary
facility: SYNEXUS Hungary Health Care Services Ltd-Zalaegerszeg-69406
city: Aurangabad
country: India
facility: Kamalnayan Bajaj Hospital
city: Bikaner
country: India
facility: S.P. Medical College & Associated Group of Hospitals
city: Chennai
country: India
facility: Apollo Speciality Hospital
city: Kanpur
country: India
facility: LPS Institute of Cardiology
city: Maharashtra
country: India
facility: Shrikrishna Hrudayalaya and Critical Care Centre
city: New Delhi
country: India
facility: Batra Hospital and Medical Research Centre
city: New Delhi
country: India
facility: Sir Gangaram Hospital
city: Surat
country: India
facility: Shri B.D. Mehta Mahavir Heart Institute
city: Dublin 4
country: Ireland
facility: St. Vincent's University Hospital
city: Galway
country: Ireland
facility: University Hospital Galway
city: Bergamo
country: Italy
facility: Humanitas Gavazzeni
city: Latina
country: Italy
facility: Ospedale S.M. Goretti
city: Milano
country: Italy
facility: IRCCS MultiMedica
city: Milano
country: Italy
facility: Centro Cardiologico Monzino-IRCCS
city: Palermo
country: Italy
facility: Policlinico "Paolo Giaccone"
city: Roma
country: Italy
facility: Università Campus Bio-Medico - ROMA
city: Roma
country: Italy
facility: AOU Policlinico Umberto I
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario A. Gemelli IRCCS
city: Siena
country: Italy
facility: A.O.U. Senese Policlinico Santa Maria alle Scotte
city: Torino
country: Italy
facility: AO Città della Salute e Scienza
city: Aichi, Nagoya
country: Japan
facility: Meitetsu Hospital
city: Aichi, Nagoya
country: Japan
facility: Nagoya Kyoritsu Hospital
city: Aichi, Nagoya
country: Japan
facility: Chubu Rosai Hospital
city: Aichi, Nagoya
country: Japan
facility: Daido Clinic
city: Chiba, Matsudo
country: Japan
facility: Seikeikai New Tokyo Heart Clinic
city: Fukuoka, Okawa
country: Japan
facility: Takagi Hospital
city: Fukushima, Koriyama
country: Japan
facility: Seino Internal Medicine Clinic
city: Kanagawa, Kawasaki
country: Japan
facility: Matsuba Clinic
city: Kanagawa, Sagamihara
country: Japan
facility: Sagamihara Kyodo Hospital
city: Kanagawa, Yokohama
country: Japan
facility: Saiseikai Yokohamashi Nanbu Hospital
city: Kochi, Kochi
country: Japan
facility: Takeshita Hospital
city: Kyoto, Kuse-gun
country: Japan
facility: Kyoto Okamoto Memorial Hospital
city: Mito, Ibaraki
country: Japan
facility: Iryouhouijneiwakai Minamiakatsuka Clinic
city: Miyagi, Sendai
country: Japan
facility: Sato Hospital
city: Okinawa, Urasoe
country: Japan
facility: Urasoe General Hospital
city: Osaka, Osaka
country: Japan
facility: Osaka Keisatsu Hospital
city: Saitama, Kawaguchi
country: Japan
facility: Saiseikai Kawaguchi Hospital
city: Saitama, Koshigaya
country: Japan
facility: Koshigaya Municipal Hospital
city: Saitama, Sayama
country: Japan
facility: Saitama Sekishikai Hospital
city: Saitama, Sayama
country: Japan
facility: Sayama General Clinic
city: Shiga, Omihachiman
country: Japan
facility: Omihachiman Community Medical Center
city: Tokyo, Hachioji
country: Japan
facility: Minamino Cardiovascular Hospital
city: Tokyo, Suginami-ku
country: Japan
facility: NewHeart Watanabe Institute
city: Wakayama, Wakayama
country: Japan
facility: Saiseikai Wakayama Hospital
city: Almaty
country: Kazakhstan
facility: Institute of Gastroenterology, Gepatology and Metabolism LLP
city: Almaty
country: Kazakhstan
facility: Academy of Preventive Medicine, Clinic "Vitalem"
city: Astana
country: Kazakhstan
facility: Multidisciplinary City Hospital №1 of the Akimat of Astana
city: Astana
country: Kazakhstan
facility: National Research Medical Center (NNMC)
city: Busan
country: Korea, Republic of
facility: Pusan National Univ. Hosp
city: Cheongju
country: Korea, Republic of
facility: Chungbuk National University Hospital
city: Daegu
country: Korea, Republic of
facility: Keimyung University Dongsan Hospital
city: Daegu
country: Korea, Republic of
facility: Yeungnam University Medical Center
city: Daejeon
country: Korea, Republic of
facility: Chungnam National University Hospital
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital at Gangdong
city: Seoul
country: Korea, Republic of
facility: Gangnam Severance Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Wonju-si, Gangwon State
country: Korea, Republic of
facility: Yonsei University Wonju Severance Christian Hospital
city: Chihuahua
country: Mexico
facility: ENCLIFAR Ensayos Clinicos Farmacologicos, S.C.
city: Ciudad de Mexico
country: Mexico
facility: Clinica Omega Diabetes
city: Cuernavaca
country: Mexico
facility: Instituto de Diabetes, Obesidad y Nutrición S.C.
city: Culiacan
country: Mexico
facility: Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C.
city: Monterrey
country: Mexico
facility: Cardiolink Clin Trials S.C.
city: México
country: Mexico
facility: CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
city: Arnhem
country: Netherlands
facility: Rijnstate Hospital
city: Haarlem
country: Netherlands
facility: Spaarne Ziekenhuis
city: Utrecht
country: Netherlands
facility: Diakonessenhuis Utrecht
city: Veldhoven
country: Netherlands
facility: Maxima Medisch Centrum
city: Palmerston North
country: New Zealand
facility: P3 Research Palmerston North
state: Migration Data
city: Auckland
country: New Zealand
facility: Optimal Clinical Trials
city: Christchurch
country: New Zealand
facility: Pacific Clinical Research Network - Forte Christchurch
city: Lower Hutt
country: New Zealand
facility: P3 Research Lower Hutt
city: Papatoetoe
country: New Zealand
facility: Middlemore Clinical Trials
city: Rotorua
country: New Zealand
facility: Pacific Clinical Research Network - Rotorua
city: Waikanae Beach
country: New Zealand
facility: P3 Research Kapiti
city: Drammen
country: Norway
facility: Vestre Viken HF, Drammen Sykehus
city: Lørenskog
country: Norway
facility: Akershus Universitetssykehus HF
city: Trondheim
country: Norway
facility: St. Olavs Hospital, Universitetssykehuset i Trondheim
city: Tønsberg
country: Norway
facility: Sykehuset i Vestfold, Avd. Tønsberg
city: Bialystok
country: Poland
facility: Medical University of Bialystok
city: Bialystok
country: Poland
facility: Trial Medica
city: Bydgoszcz
country: Poland
facility: INTERCORE Medical Center
city: Bydgoszcz
country: Poland
facility: NZOZ Medical Center KERmed
city: Czestochowa
country: Poland
facility: Synexus Poland, Branch in Czestochowa
city: Gdansk
country: Poland
facility: Synexus Polska SCM Sp. z o.o. Gdansku, Gdansk
city: Gdynia
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Gdyni, Gdynia
city: Grudziadz
country: Poland
facility: NZOZ Euromedica POZ
city: Katowice
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Katowicach, Katowice
city: Katowice
country: Poland
facility: Silmedic Sp. z o.o.
city: Katowice
country: Poland
facility: Vita Longa Sp. z o.o.
city: Katowice
country: Poland
facility: Salvia Lekston I Madej Sp. J.
city: Krakow
country: Poland
facility: Diab-Endo-Met Medical Center
city: Krakow
country: Poland
facility: Unicardia Specialist Medical Center
city: Lodz
country: Poland
facility: Synexus Lodz Medical Center
city: Lodz
country: Poland
facility: Med-Gastr Medical Center
city: Lublin
country: Poland
facility: Clinical Best Solutions
city: Lublin
country: Poland
facility: Diabetology Outpatient Clinic NZOZ Specjal-Med, Lublin
city: Olsztyn
country: Poland
facility: Futuremeds Sp. z o.o. Olsztyn
city: Poznan
country: Poland
facility: Synexus Poland, Branch in Poznan
city: Poznan
country: Poland
facility: Metabolic Health Center Pawel Bogdanski
city: Poznan
country: Poland
facility: Private Practice Dr. Ewa Krzyzagorska
city: Przemysl
country: Poland
facility: Padre Pio Regional Hospital in Przemysl
city: Rzeszow
country: Poland
facility: MEDYK Medical Center
city: Skierniewice
country: Poland
facility: ETG Skierniewice
city: Sopot
country: Poland
facility: NZOZ Procordis, Cardiology Research Center of Sopot
city: Staszow
country: Poland
facility: Velocity Staszow
city: Swidnica
country: Poland
facility: DC-MED
city: Warsaw
country: Poland
facility: NBR Polska
city: Warsaw
country: Poland
facility: National Medical Institute MSWiA
city: Warsaw
country: Poland
facility: ETG Warszawa
city: Warszawa
country: Poland
facility: Clinical Best Solutions Sp. z o.o. S.K.
city: Warszawa
country: Poland
facility: Centrum Medyczne Synexus
city: Wroclaw
country: Poland
facility: Synexus Poland, Branch in Wroclaw
city: Alcabideche
country: Portugal
facility: Hospital de Cascais Dr. José de Almeida
city: Aveiro
country: Portugal
facility: ULS da Região de Aveiro
city: Braga
country: Portugal
facility: ULS Braga
city: Coimbra
country: Portugal
facility: ULS de Coimbra, E.P.E.
city: Guimarães
country: Portugal
facility: ULS do Alto Ave
city: Lisboa
country: Portugal
facility: ULS de São José
city: Lisboa
country: Portugal
facility: APDP - Associação Protectora dos Diabéticos de Portugal
city: Lisboa
country: Portugal
facility: Hospital da Luz
city: Ponte de Lima
country: Portugal
facility: Cardiolima - Centro Diagnostico Cardio-pulmonar de Ponte de Lima, Lda.
city: Santa Maria da Feira
country: Portugal
facility: ULS de Entre Douro e Vouga
city: Torres Novas
country: Portugal
facility: UCARDIO
city: Vila Nova de Gaia
country: Portugal
facility: Hospital da Luz Arrábida
city: Bayamon
country: Puerto Rico
facility: Advanced Clinical Research
city: Ponce
country: Puerto Rico
facility: Ponce School of Medicine/CAIMED Center
city: Dammam
country: Saudi Arabia
facility: King Fahad Specialist Hospital - Research Center
city: Jeddah
country: Saudi Arabia
facility: King AbdulAziz University Hospital
city: Riyadh
country: Saudi Arabia
facility: King Faisal Specialist Hospital and Research Center
city: Riyadh
country: Saudi Arabia
facility: King Saud Medical City
city: Bratislava
country: Slovakia
facility: METABOL KLINIK s.r.o., Bratislava
city: Bratislava
country: Slovakia
facility: MEDISPEKTRUM s.r.o., Bratislava
city: Kosice
country: Slovakia
facility: Medical Group Kosice s.r.o
city: Lucenec
country: Slovakia
facility: IN-DIA s.r.o., Lucenec
city: Nove Zamky
country: Slovakia
facility: Funkystuff s.r.o.
city: Roznava
country: Slovakia
facility: DIAB sro
city: Alicante
country: Spain
facility: Hospital General Universitario de Alicante
city: Badajoz
country: Spain
facility: Hospital Universitario de Badajoz
city: Barcelona
country: Spain
facility: Centro Médico Teknon
city: Barcelona
country: Spain
facility: Hospital Vall d'Hebron
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
city: Bilbao
country: Spain
facility: Hospital de Basurto
city: Girona
country: Spain
facility: Hospital Universitari de Girona Doctor Josep Trueta
city: Granada
country: Spain
facility: Hospital Universitario San Cecilio
city: Madrid
country: Spain
facility: Hospital La Paz
city: Malaga
country: Spain
facility: Hospital Virgen de la Victoria
city: Pozuelo de Alarcón
country: Spain
facility: Hospital Quirónsalud Madrid
city: Santander
country: Spain
facility: Hospital Universitario Marqués de Valdecilla
city: Santiago de Compostela
country: Spain
facility: Complexo Hospitalario Universitario De Santiago
city: Sevilla
country: Spain
facility: Hospital Quironsalud Infanta Luisa
city: Valencia
country: Spain
facility: Hospital Dr. Peset
city: Changhua
country: Taiwan
facility: Chang-Hua Christian Hospital
city: Chia-Yi City
country: Taiwan
facility: Chia-Yi Christian Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Tainan
country: Taiwan
facility: NCKUH
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital
city: Taoyuan County
country: Taiwan
facility: Chang Gung Memorial Hospital(Linkou)
city: Adana
country: Turkey
facility: Adana City Hospital
city: Adana
country: Turkey
facility: Baskent University Hospital
city: Antalya
country: Turkey
facility: Akdeniz UTF Endokrinoloji ve Metabolizma Hastaliklari BD
city: Battalgazi
country: Turkey
facility: Inonu Uni. Med. Fac., Battalgazi
city: Bursa
country: Turkey
facility: Bursa Yuksek Ihtisas EAH
city: Diyarbakir
country: Turkey
facility: Dicle Universitesi Tip Fakultesi
city: Istanbul
country: Turkey
facility: Koc Universitesi Hastanesi
city: Istanbul
country: Turkey
facility: Istanbul Universitesi Cerrahpasa Tip Fakultesi-Istanbul-1433
city: Istanbul
country: Turkey
facility: Acibadem Universitesi Atakent Hastanesi
city: Istanbul
country: Turkey
facility: İstanbul Prof.Dr. Cemil Taşçıoğlu City Hospital
city: Istanbul
country: Turkey
facility: Istanbul Universitesi Istanbul Tip Fakultesi
city: Istanbul
country: Turkey
facility: Marmara Universitesi Tip Fakultesi
city: Zonguldak
country: Turkey
facility: Zonguldak Bulent Ecevit UTF
city: Airdrie
country: United Kingdom
facility: University Hospital Monklands
city: Antrim
country: United Kingdom
facility: Antrim Area Hospital
city: Cardiff
country: United Kingdom
facility: Synexus - Cardiff
city: Chorley
country: United Kingdom
facility: Synexus - Lancashire
city: Dundee
country: United Kingdom
facility: Ninewells Hospital & Medical School
city: Edgbaston
country: United Kingdom
facility: Synexus - Midlands
city: Edinburgh
country: United Kingdom
facility: Wellcome Trust Clinical Research Facility, Edinburgh
city: Glasgow
country: United Kingdom
facility: Queen Elizabeth University Hospital
city: Glasgow
country: United Kingdom
facility: Synexus - Glasgow
city: Hexham
country: United Kingdom
facility: Synexus - Hexham
city: Leicester
country: United Kingdom
facility: Leicester General Hospital
city: Lincoln
country: United Kingdom
facility: Lincoln County Hospital
city: Liverpool
country: United Kingdom
facility: Synexus - Merseyside
city: Londonderry
country: United Kingdom
facility: Altnagelvin Area Hospital
city: London
country: United Kingdom
facility: William Harvey Research Limited
city: Manchester
country: United Kingdom
facility: Manchester Royal Infirmary
city: Manchester
country: United Kingdom
facility: Synexus - Manchester
city: Newcastle upon Tyne
country: United Kingdom
facility: Royal Victoria Infirmary
city: Swansea
country: United Kingdom
facility: Swansea University Medical School
city: Wishaw
country: United Kingdom
facility: University Hospital Wishaw
Study officials:
References: