Clinical trial NCT00316043: Prevention of Renal Failure in Children With Urinary Tract Infections
Official title: Prevention of Renal Failure in Children With Urinary Tract Infections in General Practice: Current Clinical Management, Possibilities for Improvement and Potential Cost-Efficiency
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Urinary Tract Infections
Keywords: Urinary tract infections
Renal failure
Renal scarring
Prevention
Primary Care
General Practice
Intervention Studies
Children
Lead sponsor: Radboud University Medical Center
Sponsor class: OTHER
Collaborators: name: Dutch Kidney Foundation
First posted: 2006-04-19
Enrollment: 124
Sex: ALL
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL

Brief summary: The aim of the study is to describe the current clinical management of young children with urinary tract infections in Dutch primary care and also to describe the possibilities for improvement and potential cost-efficiency of improved care in the light of preventing renal failure.

Detailed description: The aim of the study is to describe the current clinical management of young children with urinary tract infections in Dutch primary care and also to describe the possibilities for improvement and potential cost-efficiency of improved care in the light of preventing renal failure.

The 4 phases of the study contain the following questions:

* Phase 1: What is the current clinical management of urinary tract infections in young children in primary care?
* Phase 2: What are the possibilities for improving the clinical management of urinary tract infections and are these improvements practically achievable?
* Phase 3: What is the cost-efficiency of the several interventions for improving clinical management of urinary tract infections
* Phase 4: What is the influence of the intervention on clinical management?

Eligibility criteria: Inclusion Criteria:

* children between 0-12 years of age with a proven urinary tract infection in general practice

Exclusion Criteria:

-

Primary outcomes:
measure: Number of antibiotic prescriptions
timeFrame: 10 days after 1st contact with GP
measure: Number of referrals
timeFrame: 10 days after 1st contact with GP
measure: Number of follow-up appointments
timeFrame: 10 days after 1st contact with GP
Secondary outcomes:
Other outcomes:
Locations:
city: Nijmegen
country: Netherlands
facility: UMC St Radboud
state: Gelderland
Study officials:
affiliation: UMC St Radboud
name: Michel Wensing, dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ahmed SM, Swedlund SK. Evaluation and treatment of urinary tract infections in children. Am Fam Physician. 1998 Apr 1;57(7):1573-80, 1583-4.
citation: Owen D, Vidal-Alaball J, Mansour M, Bordeaux K, Jones KV, Edwards A. Parent's opinions on the diagnosis of children under 2 years of age with urinary tract infection. Fam Pract. 2003 Oct;20(5):531-7. doi: 10.1093/fampra/cmg507.
citation: Harmsen, M et al. Urinary tract infections in young children: high guideline adherence of triage nurses at general practice co-operatives. Quality in Primary Care, 13: 241-7, 2005
citation: Kwok WY, de Kwaadsteniet MC, Harmsen M, van Suijlekom-Smit LW, Schellevis FG, van der Wouden JC. Incidence rates and management of urinary tract infections among children in Dutch general practice: results from a nation-wide registration study. BMC Pediatr. 2006 Apr 4;6:10. doi: 10.1186/1471-2431-6-10.
citation: Jacobson SH, Eklof O, Eriksson CG, Lins LE, Tidgren B, Winberg J. Development of hypertension and uraemia after pyelonephritis in childhood: 27 year follow up. BMJ. 1989 Sep 16;299(6701):703-6. doi: 10.1136/bmj.299.6701.703.
citation: Vernon SJ, Coulthard MG, Lambert HJ, Keir MJ, Matthews JN. New renal scarring in children who at age 3 and 4 years had had normal scans with dimercaptosuccinic acid: follow up study. BMJ. 1997 Oct 11;315(7113):905-8. doi: 10.1136/bmj.315.7113.905.
citation: Hansson S, Bollgren I, Esbjorner E, Jakobsson B, Marild S. Urinary tract infections in children below two years of age: a quality assurance project in Sweden. The Swedish Pediatric Nephrology Association. Acta Paediatr. 1999 Mar;88(3):270-4. doi: 10.1080/08035259950170015.
citation: Harmsen M, Wensing M, van der Wouden JC, Grol RP. Parents' awareness of and knowledge about young children's urinary tract infections. Patient Educ Couns. 2007 May;66(2):250-5. doi: 10.1016/j.pec.2006.12.009.
citation: Harmsen M, Wensing M, Braspenning JC, Wolters RJ, van der Wouden JC, Grol RP. Management of children's urinary tract infections in Dutch family practice: a cohort study. BMC Fam Pract. 2007 Mar 13;8:9. doi: 10.1186/1471-2296-8-9.