Clinical trial NCT00811369: Trial to Evaluate the Therapeutic Benefit of Fulvestrant in Combination With ZACTIMA in Postmenopausal Women With Bone Predominant, Hormone Receptor Positive Metastatic Breast Cancer
Official title: A Phase II, Multi-Centre, Randomized, Double-blind Trial to Evaluate the Therapeutic Benefit of Fulvestrant in Combination With ZACTIMA or Fulvestrant Plus Placebo in Postmenopausal Women With Bone Only or Bone Predominant, Hormone Receptor Positive Metastatic Breast Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Metastatic Breast Cancer
Keywords: Breast Cancer
Bone Metastases
Telopeptide
Zactima
Fulvestrant
Lead sponsor: Ontario Clinical Oncology Group (OCOG)
Sponsor class: OTHER
Collaborators: name: AstraZeneca
First posted: 2008-12-19
Enrollment: 126
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate whether the combination of fulvestrant and ZACTIMA, versus fulvestrant plus placebo, results in a significant decrease in the bone marker, urinary N-Telopeptide (NTx) in postmenopausal women with bone only, or bone predominant, hormone receptor-positive metastatic breast cancer. A significant decrease will be defined as a \> 30% reduction in urinary NTx level from baseline.

Detailed description: Tumor angiogenesis is associated with invasiveness and the metastatic potential of various cancers. Vascular endothelial growth factor (VEGF), the most potent and specific angiogenic factor, regulates normal and pathologic angiogenesis. The increased expression of VEGF has been correlated with metastases, recurrence and poor prognosis in many cancers. It has been shown the VEGF is involved in osteolysis in women with bone metastases. ZACTIMA is an agent which targets VEGF. ZACTIMA is a new agent with novel method of action - it is a VEGF inhibitor, epidermal growth factor (EGFR) inhibitor, tyrosine kinase inhibitor, as well as a potential RET kinase activity inhibitor.

In summary, women with bone only, or bone predominant, metastatic breast cancer is an ideal group to study anti-angiogenic therapies where angiogenesis could be a major factor in tumor progression and where anti-angiogenic treatment with agents like ZACTIMA could be more effective.

Eligibility criteria: Inclusion Criteria:

1. Postmenopausal woman, defined as a woman fulfilling any one of the following criteria:

   * Age greater than or equal to 60 years or
   * Age greater than or equal to 45 years with amenorrhea more than 12 months with an intact uterus or
   * Follicle-stimulating hormone (FSH) levels in postmenopausal range or
   * Having undergone a bilateral oophorectomy
2. Metastatic breast cancer with either radiologically confirmed bone only or predominant metastases to bone not considered amenable to curative treatment.
3. Evidence of hormone sensitivity either ER+ and/or PgR+, as per institutional standards, in the primary tumor.
4. Patients must fulfill one of the following RECIST criteria:

   * Bone lesions, which are lytic, sclerotic or mixed (lytic + sclerotic), in the absence of measurable disease as defined by RECIST criteria or
   * Bone lesions, which are lytic, sclerotic or mixed (lytic + sclerotic), in the presence of measurable disease as defined by RECIST criteria.
5. Patients must fulfill one of the following resistances to endocrine therapy criteria:

   * Disease progression on tamoxifen or on an aromatase inhibitor as first or second line therapy for metastatic disease or
   * Development of metastatic disease while on treatment with tamoxifen or an aromatase inhibitor in the adjuvant setting or
   * Disease progression after discontinuation of prior adjuvant endocrine therapy.

Exclusion Criteria:

1. Previous treatment with fulvestrant or ZACTIMA.
2. History of hypersensitivity to active or inactive excipients of fulvestrant and/or ZACTIMA.
3. Has received greater than one line of systemic chemotherapy for metastatic breast cancer.
4. Has received chemotherapy within the past 14 days (+ 2 days).
5. Has received radiation therapy within the past 14 days (+ 2 days).
6. Has undergone major surgery within the past 21 days or has had major surgery performed \> 21 days prior to screening and the wound remains unhealed.
7. Has received LH-RH agonist within the past 4 months.
8. Prior treatment with VEGF inhibitors (prior use of AVASTIN permitted).
9. Current or previously active systemic malignancy within 3 years prior to randomization (other than breast cancer, or adequately treated in-situ carcinoma of the cervix, uteri, or basal or squamous cell carcinoma of the skin).
10. Presence of life-threatening metastatic visceral disease, defined as extensive hepatic involvement, or any degree of brain or leptomeningeal involvement (past or present), or symptomatic pulmonary lymphangetic spread. Patients with discrete pulmonary parenchymal metastases are eligible, provided their respiratory function is not compromised as a result of disease.
11. ECOG performance status of \> 2.
12. Currently receiving (and are unwilling to discontinue) hormone replacement therapy.
13. Laboratory results sustained at:

    * Platelets \< 100 x 109 /L
    * International normalized ratio (INR) \> 1.6
    * Total bilirubin \> 1.5 times normal
    * ALT or AST \> 2.5 times normal range if no demonstrable liver metastases or \> 5 times normal range in the presence of liver metastases. No more than three retests within screening period are allowable.
14. Potassium level outside of normal range, despite supplementation; serum calcium (or ionized or adjusted for albumin), or magnesium below the lower limit of the normal range despite supplementation or creatinine clearance \< 30mL/min.
15. History of:

    * Bleeding diathesis (i.e. disseminated intravascular coagulation \[DIC\], clotting factor deficiency) or
    * Long-term anticoagulant therapy (other than anti-platelet therapy).
16. Any severe concomitant condition which makes it undesirable for the patient to participate in the study or which would jeopardize compliance with the protocol, e.g. severe renal or hepatic impairment or currently unstable or uncompensated respiratory or cardiac conditions, ongoing or active infection, untreated primary hyperparathyroidism, or psychiatric illness that would limit compliance with study requirements.
17. Anticipated life expectancy less than six months.
18. Non-approved/experimental drug treatment within previous 4 weeks before randomization.
19. Significant cardiovascular event (e.g., myocardial infarction, superior vena cava syndrome), New York Heart Association (NYHA) classification of heart disease (Appendix II) \> Class II within 3 months before study entry, or presence of cardiac disease that in the opinion of the investigator increases the risk of ventricular arrhythmia.
20. History of arrhythmia (multifocal premature ventricular contractions (PVCs), bigeminy, trigeminy, ventricular tachycardia, or uncontrolled atrial fibrillation) which is symptomatic or requires treatment (NCI CTCAE Grade 3 or 4) or asymptomatic sustained ventricular tachycardia. Atrial fibrillation, controlled on medication, is not excluded.
21. Congenital long QT syndrome or 1st degree relative with unexplained sudden death under 40 years of age.
22. QT prolongation with other medications that required discontinuation of that medication.
23. Presence of left bundle branch block (LBBB).
24. QTc with Bazett's correction measurable at \> 480msec on screening ECG. (Note: If a patient has QTc \> 480msec on screening ECG, the screen ECG may be repeated twice (at least 24 hours apart). The average QTc from the three screening ECGs must be \< 480msec in order for the patient to be eligible for the study). Patients who are receiving a drug that has a risk of QTc prolongation (see Appendix III, Table 2) are excluded if QTc is \> 460msec.
25. Hypertension not controlled by medical therapy (systolic blood pressure \> 160 millimeter of mercury (mmHg) or diastolic blood pressure \> 100mmHg).
26. Concomitant medications that are potent inducers (rifampicin, rifabutin, phenytoin, carbamazepine, phenobarbital and St. John's Wort) of CYP3A4 function.
27. Not accessible for treatment and follow up.
28. Failure to provide informed consent.

Primary outcomes:
measure: Significant change in NTx level defined as a ≥ 30% reduction in urinary NTx level from baseline.
timeFrame: Week # 1-4, 12, and every 12 weeks until disease progression/recurrence
Secondary outcomes:
measure: Progression free survival (PFS)
timeFrame: Every 12 weeks until disease progression/recurrence
measure: Response to therapy
timeFrame: Every 12 weeks until disease progression/recurrence
measure: Improvement in pain
timeFrame: Week # 1-4, 12, and every 12 weeks until disease progression/recurrence
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: Cross Cancer Institute
state: Alberta
city: Vancouver
country: Canada
facility: British Columbia Cancer Agency - Vancouver Centre
state: British Columbia
city: Halifax
country: Canada
facility: QE II Health Sciences Centre
state: Nova Scotia
city: Hamilton
country: Canada
facility: Juravinski Cancer Centre
state: Ontario
city: Kitchener
country: Canada
facility: Grand River Regional Cancer Centre
state: Ontario
city: Oshawa
country: Canada
facility: RSM Durham Regional Cancer Centre
state: Ontario
city: Ottawa
country: Canada
facility: Ottawa Hospital Cancer Centre
state: Ontario
city: Sudbury
country: Canada
facility: Regional Cancer Program of the Hôpital régional de Sudbury Regional Hospital
state: Ontario
city: Toronto
country: Canada
facility: Odette Cancer Centre - Sunnybrook Health Sciences Centre
state: Ontario
city: Toronto
country: Canada
facility: St. Michael's Hospital
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Hospital
state: Ontario
city: Montreal
country: Canada
facility: Centre Hospitalier De L'Universite De Montreal - Hotel Dieu
state: Quebec
city: Saskatoon
country: Canada
facility: Saskatoon Cancer Centre
state: Saskatchewan
Study officials:
affiliation: The Ottawa Hospital Regional Cancer Centre
name: Mark Clemons, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Odette Cancer Centre - Sunnybrook Health Sciences Centre
name: Rebecca Dent, MD
role: PRINCIPAL_INVESTIGATOR
References: