louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05901402: Application of Aerobic and Resistance Exercise in Blood Glucose Control in Pregnant Women With GDM
Official title: Application of Aerobic and Resistance Exercise in Blood Glucose Control in Pregnant Women With GDM.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Aerobic and Resistance Exercise
Keywords: the pregnant women with GDM
blood glucose
Lead sponsor: Second Affiliated Hospital of Wenzhou Medical University
Sponsor class: OTHER
First posted: 2023-06-13
Enrollment: 140
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Objective:The aim of this study was to explore the rationality and clinical value of aerobic exercise during pregnancy in blood glucose control of pregnant women with GDM, and to provide theoretical basis for more appropriate clinical exercise management.

Method:The subjects of gestational diabetes in the hospital from March 2023 to May 2024 were studied. The exercise exercise with daily responsible nurses was based on resistance exercise, mainly with upper limb muscle exercise, supplemented by lower limb muscle exercise and aerobic exercise. Fasting blood glucose, 2 hours postprandial blood glucose and HbA1c in pregnant women with GDM were monitored.


Eligibility criteria: Inclusion Criteria:

* Pregnant women with GDM without contraindications.
* Pregnant women with GDM who volunteered to participate in the project.
* Pregnant women give informed consent.

Exclusion Criteria:

* Pregnant women give up voluntarily.
* Hypoglycemia: In the presence of dizziness and other uncomfortable symptoms, people should stop exercising immediately, monitor blood sugar, and always prepare candy.
* Abdominal pain, vaginal bleeding and other symptoms of contraction should stop exercising immediately and seek medical attention in time.
* Fall: It is recommended to ensure the safety of the sports ground before exercise: keep the ground dry, clean, not easy to slip, no debris; Comfortable clothing and non-slip exercise are recommended.

Primary outcomes:
measure: Blood glucose
timeFrame: Collect blood samples and monitor fasting blood glucose in pregnant womendaily until delivery, it can be monitored for up to 10 months.
measure: 2 hours blood glucose
timeFrame: Collect blood samples and monitor 2 hours postprandial blood glucosedaily until delivery, it can be monitored for up to 10 months.
measure: HbA1c
timeFrame: Collect blood samples and monitor monthly until delivery, it can be monitored for up to 10 months.
measure: Maternal weight gain
timeFrame: Monitor weight daily until delivery by weighing scale, it can be monitored for up to 10 months.
measure: Pulse
timeFrame: Monitor the pulse of pregnant women in the experimental group during exercise until delivery, it can be monitored for up to 10 months.
Secondary outcomes:
Other outcomes:
Locations:
city: Wenzhou
country: China
facility: department of obstetrics of Second Affiliated Hospital of Wenzhou Medical University
state: Zhejiang
Study officials:
References:
Clinical trial NCT04346602: A Study on the Clinical and Psychological Characteristics of Patients With COVID-2019
Official title: A Study on the Clinical and Psychological Characteristics of Patients With COVID-2019
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: COVID-2019
Keywords: COVID-2019
clinical
psychological
symptom
Lead sponsor: Jilin University
Sponsor class: OTHER
First posted: 2020-04-15
Enrollment: 132
Sex: ALL
Minimum age (years): 1
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients with COVID-2019 would be observed.

Brief summary: A study on the clinical and psychological characteristics of patients with coronavirus disease 2019 (COVID-2019)

Detailed description: The main objective of this study is to study the clinical and psychological responses of patients with COVID-2019 during the whole treatment process. Including clinical symptoms, auxiliary examination results, and corresponding psychological changes, including depression, anxiety, insomnia, etc. This study will draw lessons about treatment and other better advices for other countries and regions.

Eligibility criteria: Inclusion Criteria:

* patients with COVID-2019

Exclusion Criteria:

* No

Primary outcomes:
measure: fever
timeFrame: one month
Secondary outcomes:
measure: cough
timeFrame: one month
measure: diarrhea
timeFrame: one month
measure: anxiety
timeFrame: two months
measure: insomnia
timeFrame: two months
measure: depression
timeFrame: two months
Other outcomes:
Locations:
city: Chang chun
country: China
facility: the First Hospital of Jilin University
state: Jilin
Study officials:
affiliation: The First Hospital of Jilin University
name: Dong Yang, Master
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yan B, Song L, Guo J, Wang Y, Peng L, Li D. Association Between Clinical Characteristics and Short-Term Outcomes in Adult Male COVID-19 Patients With Mild Clinical Symptoms: A Single-Center Observational Study. Front Med (Lausanne). 2021 Jan 5;7:571396. doi: 10.3389/fmed.2020.571396. eCollection 2020.
Clinical trial NCT03462602: Nasogastric Tube in Pancreatic Surgery
Official title: Randomized Clinical Trial for Evaluation of the Use of Nasogastric Tube Decompression After Pancreatic Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Nasogastric Tube Decompression
Pancreatic Surgery
Lead sponsor: Tongji Hospital
Sponsor class: OTHER
First posted: 2018-03-12
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Introduction: The value of routine nasogastric tube (NGT) decompression after pancreatic surgeries is not yet established. Previous studies in the setting of abdominal surgery suggested that the use of NGT does not accomplish any of its intended goals.

Methods/design: This is a prospective, randomized, controlled multicenter trial with two treatment arms. One group underwent pancreatic surgeries with routine NGT and was left in place after surgery until the patient passed flatus or stool. The other group underwent pancreatic surgeries without receiving NGT decompression, in which the NGT was removed at the end of surgery.

Discussion: Routine NGT decompression after pancreatic surgeries does or does not appear to have its anticipated advantages would be discovered in this RCT.


Eligibility criteria: Inclusion Criteria:

* Patients with age between 18 - 80 years.
* Patients underwent any kind of pancreatic surgeries, including but not limited to PD, distal pancreatectomy, central pancreatectomy, pancreatic enucleation, etc.
* Patients accepted the trial and could completed a written consent.

Exclusion Criteria:

* Combined with digestive tract obstruction before the surgery.
* History of upper abdominal surgery.
* Serious heart, brain, lung, metabolic diseases history.
* Pregnant women.
* Unwillingness or inability to consent for the study.

Primary outcomes:
measure: Time to flatus
timeFrame: 24 months
Secondary outcomes:
measure: Pulmonary complication
timeFrame: 24 months
measure: Wound infection
timeFrame: 24 months
measure: Anastomotic leak
timeFrame: 24 months
measure: Incisional hernia
timeFrame: 24 months
measure: Length of Stay
timeFrame: 24 months
measure: Gastric upset
timeFrame: 24 months
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Tongji Hospital
state: Hubei
Study officials:
affiliation: Tongji Hospital
name: Renyi Qin, pHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01338402: Evaluation of the Performance of AIR OPTIX® COLORS
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myopia
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
Collaborators: name: University of Waterloo
First posted: 2011-04-19
Enrollment: 47
Sex: ALL
Minimum age (years): 17
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: The purpose of this study was to assess the ocular response to and performance of the cosmetically printed silicone hydrogel contact lens AIR OPTIX® COLORS compared to FRESHLOOK® COLORBLENDS.

Detailed description: The study was conducted in two phases. Phase 1 was an adaptation phase where participants wore AIR OPTIX® AQUA contact lenses bilaterally (same product in both eyes) on a daily wear basis for 1 week. In Phase 2, participants wore AIR OPTIX® COLORS and FRESHLOOK® COLORBLENDS contact lenses contralaterally (different product in each eye) on a daily wear basis for 4 weeks.

Eligibility criteria: Inclusion Criteria:

* Full legal capacity to volunteer;
* Read and sign information and consent letter;
* Willing and able to follow instructions and maintain the appointment schedule;
* Ocular examination in the last two years;
* Currently wears soft contact lenses on a daily wear basis;
* Contact lens prescription between -1.50 diopters and -5.00 diopters;
* Other protocol-defined inclusion criteria may apply.

Exclusion Criteria:

* Any ocular disease;
* Any systemic condition that may affect a study outcome variable;
* Any systemic or topical medications that may affect ocular health;
* Known sensitivity to the diagnostic pharmaceuticals used in the study;
* Unable to achieve an acceptable fit with the study lenses;
* Anisometropia \>1.00 diopter or astigmatism \>0.75 diopter;
* Use of lubricating/rewetting eye drops.
* Other protocol-defined exclusion criteria may apply.

Primary outcomes:
measure: Visual Acuity
timeFrame: Phase 2: Up to Week 4
measure: Corneal Staining
timeFrame: Phase 2: Up to Week 4
measure: Conjunctival Staining
timeFrame: Phase 2: Up to Week 4
measure: Surface Regularity Index (SRI)
timeFrame: Up to Phase 2, Week 4
measure: Surface Asymmetry Index (SAI)
timeFrame: Up to Phase 2, Week 4
measure: Subjective ratings
timeFrame: Phase 2: Up to Week 4
Secondary outcomes:
Other outcomes:
Locations:
city: Waterloo
country: Canada
facility: Centre for Contact Lens Research, University of Waterloo
state: Ontario
Study officials:
affiliation: University of Waterloo Centre for Contact Lens Research
name: Desmond Fonn, MOptom, FAAO
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Waterloo Centre for Contact Lens Research
name: Lyndon Jones, PhD, FCOptom, FAAO
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02854202: High Protein Breakfast on Postprandial Glycemia in T2D (PBD)
Official title: Effect of High Protein Breakfast on Overall Postprandial Glycemia in Type 2 Diabetes
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Type 2 Diabetes
Lead sponsor: Hospital de Clinicas Caracas
Sponsor class: OTHER
Collaborators: name: Tel Aviv University
First posted: 2016-08-03
Enrollment: 60
Sex: ALL
Minimum age (years): 30
Maximum age (years): 72
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators hypothesis is that eating whey protein in breakfast will reduce overall postprandial glycemia in individuals with type 2 diabetes (T2D).

Detailed description: It was shown that increasing protein at breakfast results in reduced overall postprandial glycemia in obese individuals This study was undertaken to evaluate whether compared to proteins like tuna, eggs and soy, the intake of whey protein in the breakfast is more effective to reduce overall postprandial glycemia (PPHG) in T2D individuals.

Eligibility criteria: Inclusion Criteria:

1. Participants: from 30 to 72 years of age
2. BMI: 26 to 34 kg/m2)
3. Diabetes criteria
4. HbA1C: 7-9 % or
5. Habitually eat breakfast
6. Only naïve or treated with metformin.
7. Not dieting and no change in body weight \>10 lb = 4.5 kg within the last 3 months
8. Normal liver, kidney and thyroid function.

Exclusion Criteria:

1. Type 1 Diabetes
2. Anemia (Hg \> 10 g/dL)
3. Serum creatinine level \< 1.5 mg/dl
4. Pulmonary disease, psychiatric, immunological, neoplastic diseases or severe diabetic complications, such as cardiovascular disease, cerebrovascular disease, proliferative diabetic retinopathy, gastroparesis or underwent bariatric surgery.
5. Abnormal liver function tests defined as an increase by a factor of at least 2 above the upper normal limit of alanine aminotransferase and/or aspartate
6. Infectious disease
7. Pregnant women or lactating
8. Known hypersensitivity to milk components
9. Documented or suspected history (within one year) of illicit drug abuse or alcoholism.

Primary outcomes:
measure: Plasma glucose
timeFrame: 3 month
Secondary outcomes:
measure: Satiety
timeFrame: 3 month
measure: Change in body weight
timeFrame: 3 month
Other outcomes:
Locations:
Study officials:
affiliation: Wolfson Medical Center
name: Daniela Jakubowicz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04704102: Effects of Soft Tissue Mobilization of Neck Muscles in Individuals With Myogenous Temporomandibular Disorders: Muscle Energy Technique and Strain-counterstrain
Official title: Effects of Soft Tissue Mobilization of Neck Muscles in Individuals With Myogenous Temporomandibular Disorders: Muscle Energy Technique and Strain-counterstrain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myogenous Temporomandibular Disorders (mTMD)
Keywords: myogenous temporomandibular disorders, neck pain, muscle energy technique, strain-counterstrain, head-neck posture
Lead sponsor: Chang Gung University
Sponsor class: OTHER
First posted: 2021-01-11
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: Include elements of both longitudinal (three groups) and cross-sectional (four-weeks intervention) research designs
Primary purpose: TREATMENT

Brief summary: This is a prospective case series study.There were 20 individuals with chronic neck pain accompanied by myogenous temporomandibular disorders(mTMD) from Linkou and Taoyuan Chang Gung hospitals, and Chang-Gung university. The purpose of this study was, first, to investigate the effects of muscle energy technique (MET) or strain-counterstrain (SCS) applied on the tender or trigger points of neck muscles on improving pain and pressure pain sensitivity in neck and masticatory muscles, the maximal mouth-opening range of motion, chewing endurance, and head-neck-shoulder posture in patients with chronic neck pain accompanied by mTMD. Second, whether the significant effects could be reached within the four-week intervention duration.


Eligibility criteria: Inclusion Criteria:

* Aged 20\~65
* Self-report neck pain ≥3 months (pain occurs between superior nuchal line and 1st level of thoracic spine)
* At least one tender point at both Upper trapezius and Sternocleidomastoid muscles
* Diagnosed as mTMD according to the Diagnostic Criteria for Temporomandibular Disorders(DC/TMD)

Exclusion Criteria:

* Cognitive deficit
* Malignancy, infection, cervical or orthognathic surgery, acute pain, and history of trauma in craniocervical region
* Neurological problem or cervical radiculopathy/myelopathy
* Cervical instability with positive rotational alar ligament stress test and transverse ligament stress test, jaw dislocation
* Tooth implantation or extraction a week before study
* Vertebrobasilar insufficiency

Primary outcomes:
measure: Pain intensity in neck and masticatory muscles
timeFrame: 4 weeks
measure: Tenderness sensitivity in neck and masticatory muscles
timeFrame: 4 weeks
Secondary outcomes:
measure: Maximal mouth-opening
timeFrame: 4 weeks
measure: Chewing endurance
timeFrame: 4 weeks
measure: Head-neck-shoulder posture
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Taoyuan
country: Taiwan
facility: Yang-Hua, Lin
Study officials:
References:
Clinical trial NCT00428402: Using Focus Groups to Assess the Impact of Environmental Health Science Programs for K-12 Educational Community
Official title: Using Focus Groups to Assess the Impact of Environmental Health Science Programs for K-12 Educational Community
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: Education
4th-8th Grade Student
MIDAS Project
Focus Group Discussion
Bastrop
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
First posted: 2007-01-30
Enrollment: 6
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participant is a 4th-8th grade student in select schools from Bastrop Independent School District (BISD).

Brief summary: The MIDAS Project (Models of Implementation and Dissemination of Environmental Health and Science Across Subjects) Assessment Objectives:

* Determine whether students are aware of the MIDAS Project.
* Identify strengths and weaknesses of MIDAS Project components including: integrated environmental health and science (EHS) curricula, field experiences, seminars and student projects.
* Assess career interests and intended courses of study at the college level.

Detailed description: You are being asked to give your child permission to take part in a focus group to talk about what he or she has learned over the past year. Your child's school and other schools in the area have been working with a program called the Models of Implementation and Dissemination of Environmental Health and Science Across Subjects (MIDAS) Project. The MIDAS Project was developed by The University of Texas M.D. Anderson Cancer Center, Smithville, TX.

Purpose:

Students will be asked to share about the topics that they learned about over the past year, including their field trip experiences. Participation in the focus group is strictly voluntary, and your child may or may not choose to take part. This focus group will not be graded, and your child's name will not be recorded with his or her responses. If your child chooses not to participate in this focus group, he or she will not be penalized in any way.

Eligibility criteria: Inclusion Criteria:

* Students must be in one of the identified classes in one of the participating grades from one of the participating schools.
* Students must return a completed and signed parental consent form.
* Students must be present at school on the day that the focus groups are conducted.

Exclusion Criteria:

* Students whose parents did not complete the consent form, and/or students who do not wish to participate can opt out of the focus groups without any penalty.

Primary outcomes:
measure: Outputs From Focus Groups (Qualitative Narrative)
timeFrame: 2 Years
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: UT MD Anderson Cancer Center
state: Texas
Study officials:
affiliation: M.D. Anderson Cancer Center
name: Robin Fuchs-Young, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02386202: ARC in Hemorrhagic Stroke
Official title: Augmented Renal Clearance in Hemorrhagic Stroke Patients Admitted to the Neurosciences Intensive Care Unit
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hemorrhagic Stroke
Augmented Renal Clearance
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
First posted: 2015-03-11
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 30 patients with hemorrhagic stroke admitted to the University of North Carolina Neurosciences Intensive Care Unit

Brief summary: To determine the incidence and predictors of augmented renal clearance (ARC) in patients with hemorrhagic stroke.


Eligibility criteria: Inclusion Criteria:

* Adults ≥ 18 years
* Patients with hemorrhagic stroke
* Anticipated length of stay in the neuroscience intensive care unit \> 48 hours
* Informed consent provided by the patient or by the patient's designated medical proxy

Exclusion Criteria:

* Pregnancy
* Patients with pre-existing renal dysfunction (chronic kidney disease stages 3 - 5)
* Patients receiving renal replacement therapy
* Patients with an admission serum creatinine \> 1.4 mg/dL
* Patients with non-aneurysmal subarachnoid hemorrhage
* Patients with history of nephrectomy or body mass index \< 18 kg/m2

Primary outcomes:
measure: To describe the onset, magnitude, and change over time of ARC in patients with hemorrhagic stroke
timeFrame: Over neurosciences intensive care unit stay
Secondary outcomes:
Other outcomes:
Locations:
city: Chapel Hill
country: United States
facility: University of North Carolina Hospitals
state: North Carolina
Study officials:
affiliation: UNC Eshelman School of Pharmacy
name: Kathryn A Morbitzer, PharmD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01148602: The CLOQS Trial - Countdown Lights to Optimize Quality in Stroke
Official title: The CLOQS Trial - Countdown Lights to Optimize Quality in Stroke
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acute Stroke
Keywords: Acute stroke
Emergency departments
Quality Improvement
Improved Processes
tPA
door-to-needle
door-to-treatment
Lead sponsor: Sunnybrook Health Sciences Centre
Sponsor class: OTHER
Collaborators: name: University Health Network, Toronto
name: Unity Health Toronto
First posted: 2010-06-22
Enrollment: 3452
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: To reduce door-to-needle times in acute stroke treatment. Using an organizational behaviour intervention (a large stopwatch), we will post a visual cue to remind all parties that "time is brain". We hypothesize that this simple visual cue will improve door-to-CT scan times and door-to-needle treatment times, and thus improve treatment response, and reduce adverse events.

Detailed description: We will construct a large, "in-your-face" red LED stopwatch-clock that is the intervention. The clock will be attached to the stretcher of patients presenting for hyperacute stroke treatment (consideration of tissue plasminogen activator (tPA) treatment at the moment of their Emergency department arrival. This will act as a constant visual reminder to all team members (physicians, RN's, CT technologists) of the urgency of the situation. The study will be a block randomization, by week of presentation. All patients presenting during "on" weeks will have a stopwatch timer with them during the hyperacute stroke workup. During "off" weeks, the clocks will not be used.

Eligibility criteria: Inclusion Criteria:

* All patients who present to the emergency room with acute stroke for consideration of treatment with tPA.

Exclusion Criteria:

* Patients presenting to the emergency room (door time) more than 4.5 hours after symptom onset

Primary outcomes:
measure: Improved door-to-CT and door-to-needle times.
timeFrame: 18 months
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Sunnybrook Health Sciences Centre
state: Ontario
city: Toronto
country: Canada
facility: St. Michael's Hospital
state: Ontario
city: Toronto
country: Canada
facility: University Health Network - Toronto Western Hospital
state: Ontario
Study officials:
affiliation: University of Toronto Stroke Program
name: Richard Swartz, MD
role: PRINCIPAL_INVESTIGATOR
References: