Clinical trial NCT03302923: Brisk Walking Study in Nursing Home Residents
Official title: Effects of Brisk Walking on Autonomic Nervous System Reactivation in Nursing Home Residents.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Physical Activity
Autonomic Nervous System Imbalance
Keywords: Nursing home residents
Brisk walking
Lead sponsor: Clinique Mutualiste Chirurgicale de la Loire
Sponsor class: OTHER
Collaborators: name: University Hospital of Saint-Etienne
name: University of Lyon
First posted: 2017-10-05
Enrollment: 100
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: It is well established that physical activity reduces the physiological effects of ageing. Among them, the decrease of the autonomic nervous system activity (ANS) is associated with the increase of cardiovascular events and sleep disorders occurence. It has been shown that high intensity cycle training can enhance the ANS activity by 30% in people aged of 70 years old. However, such trainings were done by old athletes used to train at intensities that could not be handled by nursing home elderly. Thus, an adapted activity such as brisk walking shall be defined to make it practicable for the many in convalescent homes. The investigators hypothesize that long term brisk walking training could lead to reactivate ANS in people living in convalescent homes.

Detailed description: The investigators aim to compare the effects of a 9 month brisk walking training (1 time a week or 3 times a week) on the ANS of nursing home residents.

Eligibility criteria: Inclusion Criteria:

* Being over 60 years old
* Living in a nursing home of Mutualité Française de la Loire, France
* Being able to walk without human aid
* Being able to speak and write French
* Being inactive (less than 1 hours of physical activity per week)
* Having a normal sinus rhythm
* Being affiliated to the social welfare system
* Signing the informed consent form

Exclusion Criteria:

* Having serious balance disorders
* Suffering from cardiac or respiratory pathologies that contraindicate physical activity
* Serious comorbidities contraindicating physical activity
* Diagnosed cardiac pathologies that prevent heart rate variability analysis: congestive heart failure, cardiac pacemaker, implantable cardioverter defibrillator, serious ventricular rhythm troubles, atrial fibrillation, atrial flutter.
* Persons under legal protection

Primary outcomes:
measure: SDNN value
timeFrame: 9 months
Secondary outcomes:
measure: Heart rate variability parameters
timeFrame: 9 months
measure: Heart rate variability parameters
timeFrame: 9 months
measure: Heart rate variability parameters
timeFrame: 9 months
measure: Baroreflex sensitivity (BRS)
timeFrame: 9 months
measure: Maximum oxygen uptake (VO2max)
timeFrame: 9 months
measure: Daily physical activity
timeFrame: 9 months
measure: Daily physical activity
timeFrame: 9 months
measure: Sedentary periods
timeFrame: 9 months
measure: Sedentary periods
timeFrame: 9 months
measure: Muscular force
timeFrame: 9 months
measure: Muscular endurance
timeFrame: 9 months
measure: Muscular volume gains
timeFrame: 9 months
measure: Plasmatic dosages of inflammatory molecules
timeFrame: 9 months
measure: Plasmatic dosages of inflammatory molecules
timeFrame: 9 months
measure: Plasmatic dosages of inflammatory molecules
timeFrame: 9 months
measure: Cognitive improvements
timeFrame: 9 months
measure: Quality of life
timeFrame: 9 months
Other outcomes:
Locations:
city: Saint-Étienne
country: France
facility: French Loire Mutuality
Study officials:
affiliation: University Hospital of Saint-Etienne
name: David HUPIN, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: