Clinical trial NCT06720103: Correlation Between Radiculopathy And Quality Of Life In Patients With Chronic Lumbar Spondylosis
Official title: Correlation Between Radiculopathy And Quality Of Life In Patients With Chronic Lumbar Spondylosis
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Lumbar Spondylosis
Keywords: quality of life
radiculopathy
lumbar spondylosis
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-12-06
Enrollment: 132
Sex: ALL
Minimum age (years): 30
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: one hundred thirty-two subjects (who have chronic lumbar spondylosis); from both genders will participate in this study.

Brief summary: This study will be conducted to answer the following question:

Is there a Correlation Between Lumbar Radiculopathy and Quality of Life in Patients with chronic lumbar spondylosis?

Detailed description: Spondylosis is an age-related change of vertebrae and discs of the spine. These changes are often called degenerative disc disease and osteoarthritis. When this condition is in the lower back, it's called lumbar spondylosis.

Lumbar osteoarthritis, disc degeneration, degenerative disc disease, and spondylosis are some of the terms used to describe disc changes. In fact, the condition is called spondylosis. Whenever there is a degeneration co-occurrence in the disc, the lumbar spine, the formation of osteophytes and the associated changes in the nerves and the resulting symptoms of pain.Spinal osteoarthritis (OA) is a degenerative process defined radiologically by joint space narrowing, osteophytosis, subchondral sclerosis, and cyst formation.

Osteophytes included within this definition fall into one of the two primary clinical categories.

The first, spondylosis deforms describes bony outgrowths arising primarily along the anterior and lateral perimeters of the vertebral endplate apophyses. These hypertrophic changes are believed to develop at sites of stress to the annular ligament and most commonly occur at thoracic T9-10 and lumbar L3 levels.These conditions lead to nerve root compression, resulting in radiating pain down the leg, commonly referred to as sciatica. The impact of lumbar radiculopathy extends beyond pain, affecting muscle function and neuromuscular control. The involvement of nerve roots such as L4, L5, and S1 can particularly affect the muscles in the lower extremities, including the plantar flexor muscles, which are crucial for movements like walking, running, and maintaining balance

Eligibility criteria: Inclusion Criteria:

* All patient diagnosed and referred from a physician
* Patients suffered from lumbar spondylosis (L4: L5) with radiculopathy more than 3 months
* Participants will be from both gender
* Age will be ranged from 30 to 50.
* BMI of all participants ≤ 30 kg/m2

Exclusion Criteria:

* Pregnant and breast-feeding women
* Patients diagnosed with depression and anxiety
* Patient who had undergone lumbar spine surgery
* People with systemic illnesses or physical deformities

Primary outcomes:
measure: life disability
timeFrame: up to one day
Secondary outcomes:
measure: sciatic radiculopathy
timeFrame: up to one day
measure: mechanosensitivity of the neuromeningeal structures within the vertebral canal
timeFrame: up to one day
Other outcomes:
Locations:
Study officials:
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