louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01379001: Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusion MRI
Official title: Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusion MRI
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cholinergic Function
Keywords: cholinergic function
aging
pharmacologic MRI
Lead sponsor: Hebrew SeniorLife
Sponsor class: OTHER
First posted: 2011-06-23
Enrollment: 60
Sex: ALL
Minimum age (years): 21
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: This research study will look at how medications affect the pattern of blood flow in the brain. This study will use a special type of MRI (magnetic resonance imaging) scan called perfusion MRI to make measurements of cerebral (brain) blood flow. The medications we will use in this study are scopolamine (commonly used to treat motion sickness), mecamylamine (used to treat high blood pressure), and donepezil (used to treat memory loss). Cognitive testing will also be obtained, and correlated with the blood flow patterns in the brain.

Detailed description: Project Summary: This research project will investigate the value of combined pharmacologic manipulation and arterial spin-labeled perfusion MRI (pharmacologic ASL-pMRI) as an in vivo probe of cholinergic function. Methods to investigate cholinergic function in vivo are needed to better understand the role of acetylcholine in the physiology of the cerebral cortex, and in cognitive processes in health and in disease states. In this study, pharmacologic ASL-pMRI will be used to characterize the normal cerebral perfusion response to cholinergic manipulation in young healthy subjects. Cognitive measures will also be obtained and correlated with cerebral perfusion changes. Pharmacologic ASL-pMRI and cognitive testing will then be used to study how the cholinergic response is altered with normal aging and in delirium

Eligibility criteria: Inclusion Criteria:

* healthy volunteers

Exclusion Criteria:

* Any neurological condition, such as brain tumor, history of stroke, seizure disorder, attention deficit disorder, normal pressure hydrocephalus, dementia, traumatic brain injury
* Any major medical conditions, such a cancer, diabetes, glaucoma, prostate disease, uncontrolled hypertension
* antihistamine use
* tricyclic antidepressant use
* presence of metal in body, including pacemaker, defibrillator, neurostimulator, metal implants, or foreign metal objects such as bullets or shrapnel.
* anxiety or panic disorder
* history of claustrophobia
* pregnancy

Primary outcomes:
measure: Cerebral blood flow
timeFrame: 3 hours
Secondary outcomes:
measure: cognitive performance
timeFrame: 4 hours
Other outcomes:
Locations:
Study officials:
affiliation: Hebrew Rehabilitation Center
name: Tamara Fong, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05467501: Effect of Therapeutic Ultrasound Versus Anti-inflammatory Drugs in the Treatment of Trigger Finger
Official title: Principal Investigator
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Trigger Finger
Keywords: Trigger Finger
Therapeutic Ultrasound
Lead sponsor: General Committee of Teaching Hospitals and Institutes, Egypt
Sponsor class: OTHER_GOV
First posted: 2022-07-20
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: RCT
Primary purpose: TREATMENT

Brief summary: to determine the effect of US on pain intensity in TF patients 2) to determine the effect of US on number of daily finger triggering in TF patients.

Detailed description: Trigger finger (T.F) is a disorder characterized by snapping or locking of a finger. Painful popping or clicking sound is elicited by flexion and extension of the involved digit . It is a multifactorial disease. The common mechanism of triggering is that there is a mismatch of diameter between flexors tendons and the annular pulley (retinacular sheath) of the finger. Some studies found inflammatory cells as a part of the pathology, hence anti-inflammatory drugs are the first line of treatment .

Therapeutic ultrasound (US) is a form of acoustic energy which is often used in physical therapy. When US enters the body, it can affect the cells and tissues through thermal and non-thermal mechanisms. While a thermal mechanism has a direct heating effect which promotes anti-inflammatory response with increase blood flow, evidence indicates, however, that non thermal mechanisms are thought to play a primary role in producing a therapeutically significant biological effect (i.e. the stimulation of tissue regeneration) . So my question is in T.F patients does therapeutic ultrasound decrease pain more than anti-inflammatory drugs?

Eligibility criteria: Inclusion Criteria:

1 - patients will be included to this study if they are trigger finger patients ( clinically evaluated and refereed by orthopedist).

Exclusion Criteria:

1 - complete locked finger. 2-Ages below 18 y. 3-Patients with any other hand pathology .

Primary outcomes:
measure: pain intensity
timeFrame: 6 month - 1 year
Secondary outcomes:
measure: number of daily finger triggering
timeFrame: 6 month - 1 year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01268501: Clinical Assessment of a Multifocal Contact Lens for People Who Use Reading Glasses Only
Official title: Clinical Assessment of a New Multifocal Contact Lens With Emmetropic Presbyopes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Presbyopia
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
First posted: 2010-12-31
Enrollment: 103
Sex: ALL
Minimum age (years): 40
Maximum age (years): 48
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this trial is to evaluate the use of multifocal contact lenses in people who use reading glasses only.


Eligibility criteria: Inclusion Criteria:

* Is between 40 and 48 years of age (inclusive).
* Has read and signed the Informed Consent.
* Is willing and able to follow instructions and maintain the appointment schedule.
* Wears reading spectacles for close work.
* Other protocol-defined inclusion/exclusion criteria may apply.

Exclusion Criteria:

* Eye injury or surgery within twelve weeks of enrollment.
* Evidence of systemic or ocular abnormality, infection, or disease likely to affect successful wear of contact lenses or use of accessory solutions.
* Currently enrolled in a clinical trial.
* Has worn contact lenses previously.
* Other protocol-defined inclusion/exclusion criteria may apply.

Primary outcomes:
measure: Overall Convenience With Contact Lenses
timeFrame: 3 weeks of wear
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03772301: Evaluation of Hoarding Behaviour and Eating Disorders Among Holocaust Survivors and Their Descendants
Official title: Evaluation of Hoarding Behaviour and Eating Disorders Among Holocaust Survivors and Their Descendants
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hoarding Disorder
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2018-12-11
Enrollment: 1000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Jewish Holocaust survivors living in Germany and Israel Their direct offspring and their children (second and third generation)

Brief summary: "Hoarding "is a common behavior among Holocaust survivors and is related to the traumatic events they have experienced, and we assume that storage behavior and eating disorders are related to future generations of Holocaust survivors.


Eligibility criteria: Inclusion Criteria:

1. Jewish Holocaust survivors living in Germany and Israel who have expressed their written and written consent to participate in monitoring and testing, and who are able to answer the research questionnaires.

   • Their direct offspring and their children (second and third generation)
2. The control population - non-Jewish subjects who are not the descendants of Holocaust survivors living in Germany who have expressed their written and oral consent to participate in monitoring and testing and who are able to answer the research questionnaires and whose parents were not imprisoned in the camps second.

Exclusion Criteria:

* (Participants who do not agree to participate (did not sign informed consent form
* Respondents who are unable to answer interviewer questions
* Non-Jewish subjects whose parents were in camps (ie prisoner camps, labor camps, etc.) during the second war.

Primary outcomes:
measure: Hoarding
timeFrame: Three years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01129401: Stonewall Treatment Evaluation Project
Official title: Evaluation of a Harm Reduction Treatment for Methamphetamine-Using Men Who Have Sex With Men (MSM)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Substance Abuse
HIV Infections
Keywords: methamphetamine
men who have sex with men
HIV/AIDS
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
Collaborators: name: California HIV/AIDS Research Program
First posted: 2010-05-24
Enrollment: 150
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This treatment outcome evaluation of the Stonewall Project will recruit 150 participants to complete a face-to-face assessment visit at baseline, 3-month follow-up, and 6-month follow-up to examine treatment outcome with respect to HIV risk and substance use.

Detailed description: Stonewall Project clients who have initiated treatment within the past 60 days will be eligible for the outcome evaluation. 20% of clients are likely to be on parole or probation; these clients will be eligible to participate in the study.

Outcome measures that will be examined as part of the treatment outcome evaluation include: 1) self-reported substance use; 2) urine toxicology screening; and 3) sex risk taking.

Eligibility criteria: Inclusion Criteria:

- Participants in the outcome evaluation must have initiated services at the Stonewall Project within the past 60 days.

Exclusion Criteria:

- Inability to provide informed consent as judged by the Co-PI's and study team.

Primary outcomes:
measure: stimulant use (measured via self-report and urine toxicology screening)
timeFrame: 3 and 6 month follow-ups
Secondary outcomes:
measure: sexual risk taking
timeFrame: 3 and 6 month follow-ups
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: San Francisco AIDS Foundation
state: California
city: San Francisco
country: United States
facility: University of California, San Francisco
state: California
Study officials:
affiliation: University of California, San Francisco
name: Adam W Carrico, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: University of California, San Francisco
name: William J Woods, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: San Francisco AIDS Foundation
name: Michael D. Siever, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05320601: Efficacy of Peripheral Magnetic Stimulation Compare to Dry Needling in Myofascial Pain Syndrome
Official title: Efficacy of Peripheral Magnetic Stimulation Compare to Dry Needling in Patient With Upper Trapezius Myofascial Pain Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myofascial Pain Syndrome
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2022-04-11
Enrollment: 32
Sex: ALL
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Compare efficiency between repetitive peripheral magnetic stimulation and dry needling in patient with upper trapezius myofascial pain syndrome.


Eligibility criteria: Inclusion Criteria:

* Patients with myofascial pain syndrome at unilateral upper trapezius muscle and had pain score (Visual analog scale) at least 4

Exclusion Criteria:

* Patients with signs and/or symptoms of neurological deficit
* Patients with history of cervical hernia, cervical radiculopathy, cervical myelopathy, fibromyalgia, whiplash spondylosis and cervical spinal stenosis.
* Patients who received physical therapy/injection/surgery at neck or pain area in last 6 months.
* Patients with abnormal coagulopathy and/or currently use anticoagulant medicine.
* Patients with cardiac device.
* Patients with history of aneurysm clip procedure, stent-coils procedure or cochlear implant surgery.
* Pregnancy

Primary outcomes:
measure: Change of Visual analog scale
timeFrame: Change from baseline Visual analog scale at immediately after intervention, Change from Baseline visual analog scale at 1 week and Change from baseline Visual analog scale at 4 weeks
Secondary outcomes:
measure: Neck disability index
timeFrame: Change from baseline Neck disability index at immediately after intervention, Change from Baseline Neck disability index at 1 week and Change from baseline Neck disability index at 4 weeks
Other outcomes:
measure: Pain pressure threshold
timeFrame: Change from baseline Pain pressure threshold at immediately after intervention, Change from Baseline Pain pressure threshold at 1 week and Change from baseline Pain pressure threshold at 4 weeks
Locations:
city: Bangkok
country: Thailand
facility: Physical medicine and rehabilitation
Study officials:
affiliation: Mahidol University, Ramathibodi Hospital
name: Apiphan Iamchaimongkol, M.D.
role: STUDY_DIRECTOR
References:
Clinical trial NCT02208401: Randomised Comparison of 2 Cold Snare Polypectomy Techniques
Official title: A Prospective Randomised Comparison of Cold Snare Polypectomy Versus Cold Snare Pseudosuction Technique
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bowel Cancer
Lead sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Sponsor class: OTHER
First posted: 2014-08-05
Enrollment: 112
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Different modalities are employed to remove small colonic polyps which potentially harbour a cancer risk. But, they can all vary in their completeness of removal, safety and the histological quality and the gold standard technique has yet to be defined. A novel suction pseudopolyp technique has been described by Patullo et al and in their prospective study, 126 polyps measuring less than 10mm flat or sessile were removed by this method with 100% complete endoscopic resection and without any immediate or delayed complications. The aim of the investigators study is to compare this technique with the standard cold snare technique. Patients attending for a routine colonoscopy and found to have polyps measuring 37mm in size will be eligible and they will be randomised to the polypectomy technique. Patient demographics and polyp characteristics will be recorded. The primary outcome measured will be the macroscopic resection rate. The secondary outcome measures are abdominal pain, tenderness, bleeding and fever.


Eligibility criteria: Inclusion Criteria:

* All patients with small polyps 3-7 mm in size, flat or sessile found during colonoscopy

Exclusion Criteria:

* Patients are less than 18 years old
* Pregnant
* Inadequate bowel preparation
* On anticoagulants or clopidogrel

Primary outcomes:
measure: Complete macroscopic polyp eradication rate
timeFrame: At time of polypectomy intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Sheffield
country: United Kingdom
facility: Sheffield Teaching Hospitals NHS Foundation Trust
state: South Yorkshire
Study officials:
affiliation: Sheffield Teaching Hospitals NHS Foundation Trust
name: Shawinder Johal, MBChB, PhD, MRCP
role: PRINCIPAL_INVESTIGATOR
References:
citation: Din S, Ball AJ, Riley SA, Kitsanta P, Johal S. A randomized comparison of cold snare polypectomy versus a suction pseudopolyp technique. Endoscopy. 2015 Nov;47(11):1005-10. doi: 10.1055/s-0034-1392533. Epub 2015 Jul 10.
Clinical trial NCT00731601: Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
Official title: Phase 4 Study of Intravenous Proton Pump Inhibitor in Patients With Peptic Ulcer Bleeding After Successful Endoscopic Therapy- a Prospective Randomized Comparative Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Peptic Ulcer Hemorrhage
Keywords: shock
peptic ulcer bleeding
rebleeding
Lead sponsor: Lotung Poh-Ai Hospital
Sponsor class: OTHER
First posted: 2008-08-11
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: A large dose of PPI is effective in preventing peptic ulcer rebleeding. The investigators hypothesize that 40 mg/q6h pantoloc is equivalent to 8mg/h pantoloc in preventing rebleeding.

Detailed description: A bleeding peptic ulcer remains a serious medical problem with significant morbidity and mortality. Endoscopic therapy significantly reduces further bleeding, surgery, and mortality in patients with bleeding peptic ulcers and is now recommended as the first hemostatic modality for these patients.

In the past few years, adjuvant use of a high-dose proton pump inhibitor (PPI) after endoscopic therapy has been endorsed in some studies, two consensus statements and two meta-analysis. In our previous experience, we used omeprazole 160 mg /day infusion instead of 8 mg/h in these patients and obtained a good result .

The objectives of this study are to assess the outcomes of two different regimens of high dose of intravenous pantoprazole after endoscopic therapy in patients with peptic ulcer bleeding.

Eligibility criteria: Inclusion Criteria:

* Patients were accepted for endoscopic therapy if a peptic ulcer with active bleeding, a non-bleeding visible vessel (NBVV) or an adherent blood clot at the ulcer base was observed within 24 hours of hospital admission.

Exclusion Criteria:

* If patients were pregnant
* Did not obtain initial hemostasis with endoscopic injection of epinephrine
* Did not give written informed consent
* Had bleeding tendency (platelet count \< 50×109/L, serum prothrombin \< 30% of normal, or were taking anticoagulants), uremia.

Primary outcomes:
measure: The primary end point was recurrent bleeding before discharge and within 14 days.
timeFrame: About one year
Secondary outcomes:
measure: At day 14, volume of blood transfused, number of surgeries performed, and the mortality rates of the two groups are compared.
timeFrame: about one year
Other outcomes:
Locations:
city: Yilan
country: Taiwan
facility: Lotung Poh-Ai hospital
Study officials:
affiliation: Lotung Poh-Ai Hospital
name: Hwai-jeng Lin, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05073601: Thyroid Gland Dysfunction and Vitamin D Polymorphism in Keratoconus
Official title: Thyroid Gland Dysfunction and Vitamin D Receptor Polymorphism in Keratoconus
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Keratoconus
Keywords: Thyroid dysfunction
Vitamin D
Polymorphism
keratoconus
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2021-10-11
Enrollment: 262
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: outpatient clinic of Mansoura ophthalmic center

Brief summary: This prospective study the thyroid gland dysfunction and vitamin D receptor polymorphism in keratoconus patients

Detailed description: This is a prospective observational study in which blood samples are collected from keratoconus patients looking for thyroid dysfunction and vitamin D levels in the serum and assessing the Vitamin D receptor polymorphism in comparison to healthy control.

Eligibility criteria: Inclusion Criteria:

* keratoconus patients without previously diagnosed thyroid disorder in comparison to healthy control without known systemic disease and with normal cornea who were selected from candidates of refractive surgery with normal topography

Exclusion Criteria:

* patients who could not provide informed consent or the necessary samples for any reason, patients with associated other ophthalmic pathologies or systemic disorders were excluded from the study

Primary outcomes:
measure: concentration of free T3
timeFrame: 2month
measure: concentration of free T4
timeFrame: 2 month
measure: concentration of TSH
timeFrame: 2 month
measure: vitamin D receptor polymorphism
timeFrame: 2 month
Secondary outcomes:
measure: serum vit D
timeFrame: 2 month
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Eman Azmy
state: Dakahlia
Study officials:
affiliation: Mansoura University
name: Eman Azmy
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03919201: 12 Weeks of Resistance Band Exercise Impacts on Adiposity, Hormones, and Blood Pressure in Postmenopausal Women
Official title: Impacts of 12 Weeks of Resistance Band Exercise Training on Body Composition, Aging-related Hormones, and Blood Pressure in Postmenopausal Women With Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Hormone Disturbance
Adiposity
Keywords: postmenopausal
exercise
Lead sponsor: Pusan National University
Sponsor class: OTHER
First posted: 2019-04-18
Enrollment: 20
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: exercise intervention group, control group
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study was to examine the impacts of a 12-week resistance band exercise program on body composition, aging-related hormones, and blood pressure in postmenopausal women with stage 1 hypertension. Twenty postmenopausal women with hypertension participated in this study. Participants were randomly allocated into the resistance band training group (EX, n = 10) or the control group (CON, n = 10). The EX group performed a resistance band exercise training program at jump rope training program at 40-70% of their heart rate reserve (HRR) 5 days/week for 12 weeks (sessions 60 minutes in duration). The CON group did not participate in any exercise, dietary, or behavioral intervention. Body composition, aging-related hormones (growth hormone, insulin-like growth factor 1, dehydroepiandrosterone, and estradiol), and blood pressure were measured before and after the 12-weeks study.


Eligibility criteria: Inclusion Criteria:

* postmenopausal
* hypertensive
* sedentary (no regular exercise training or physical activity within previous year)

Exclusion Criteria:

* premenopausal
* renal, pulmonary, and/or heart disease
* regularly physically active

Primary outcomes:
measure: estradiol
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Omaha
country: United States
facility: Song-Young Park
state: Nebraska
Study officials:
References:
citation: Son WM, Pekas EJ, Park SY. Twelve weeks of resistance band exercise training improves age-associated hormonal decline, blood pressure, and body composition in postmenopausal women with stage 1 hypertension: a randomized clinical trial. Menopause. 2020 Feb;27(2):199-207. doi: 10.1097/GME.0000000000001444.