Clinical trial NCT06034990: ICU Fluid Utilization Survey in Southeast Asia
Official title: ICU Fluid Utilization Survey in Southeast Asia
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Critical Illness
Keywords: Crystalloids
Colloids
Fluid resuscitation
Intensive care unit
Sepsis
Bleeding
Lead sponsor: Chulalongkorn University
Sponsor class: OTHER
First posted: 2023-09-13
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Physicians with specialty in Anesthesiology, Surgery, Critical care medicine, Pulmonology, Nephrology, General Medicine currently working in Surgical or Medical ICU in Southeast Asia in year 2023-2024

Brief summary: The objective of this study is to examine the use of different types of fluids for resuscitation in different phases of fluid management in 3 types of critically ill patients including (1) not bleeding, not septic but need volume resuscitation (representing normal condition), (2) bleeding but not septic (representing normal vascular integrity but with a loss of intravascular colloids), (3) septic (representing the condition with increase vascular permeability and endothelium damage) in the ICU within Southeast Asia.

The data are collected by a 10-min online survey administered to included physicians which will be distributed via multiple online channels through representatives of each countries.

Detailed description: The objective of this study is to examine the use of different types of fluids for resuscitation in different phases of fluid management in 3 types of critically ill patients including (1) not bleeding, not septic but need volume resuscitation (representing normal condition), (2) bleeding but not septic (representing normal vascular integrity but with a loss of intravascular colloids), (3) septic (representing the condition with increase vascular permeability and endothelium damage) in the ICU within Southeast Asia, and to determine whether co-morbidities with hypoalbuminemia, clinician specialties, hospital practice settings, geographic locations and re-imbursement limitation especially for colloids influence the practice patterns of fluid utilization in different phases in the 3 types of patients. Ultimately, the information provided by this study could also provide basic background information for the design of future clinical trials regarding fluid resuscitation strategies.

The data are collected by a 10-min online survey administered to included physicians which will be distributed via multiple online channels through representatives of each countries.

The survey will start with an inform-consent form prior to starting the survey questions which consist of 13-item questionnaire obtaining information on

1. Demographics data of clinicians taking the survey on primary specialty, region or country of practice and hospital settings.
2. Preferences for volume status indicators.
3. Preferences for fluid resuscitation in 3 types of patients (1. Septic 2. bleeding but not septic 3. not bleeding and not septic) during resuscitation and optimization phase.
4. Preferences for fluid resuscitation in the 3 types of patients with hypoalbuminemia including (1) cirrhosis (2) nephrotic syndrome (3) other significant hypoalbuminemia during resuscitation/optimization phase and stabilization phase
5. The reasons for using colloids for volume expansion
6. The experience of adverse reactions to albumin
7. The awareness and importance of non-oncotic properties of albumin
8. The impact of reimbursement for colloids on resuscitation fluid choice

Eligibility criteria: Inclusion Criteria:

1. Specialty must be in Anesthesiology, Surgery, Critical Care Medicine, Pulmonology, Nephrology, Internal Medicine, General Practitioner
2. Practice must be in Southeast Asia hospitals
3. Must work in Surgical ICU, Medical ICU , and/or Mixed ICU

Exclusion Criteria:

1.Physicians who worked in cardiac, neurology or pediatric ICUs

Primary outcomes:
measure: Fluid resuscitation practice pattern
timeFrame: 1/9/23-1/9/24
Secondary outcomes:
measure: Preferences for volume status indicators.
timeFrame: 1/9/23-1/9/24
measure: Fluid resuscitation practice pattern in hypoalbuminemic state
timeFrame: 1/9/23-1/9/24
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Chulalongkorn university
Study officials:
affiliation: Chulalongkorn University
name: Nattachai Srisawat, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Miller TE, Bunke M, Nisbet P, Brudney CS. Fluid resuscitation practice patterns in intensive care units of the USA: a cross-sectional survey of critical care physicians. Perioper Med (Lond). 2016 Jun 16;5:15. doi: 10.1186/s13741-016-0035-2. eCollection 2016.