Clinical trial NCT02873143: 5 Year Follow-up of Adolescents With Knee Pain
Official title: 5 Year Follow-up of Adolescents With Knee Pain - a Prospective Cohort Study of 504 Adolescents
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Patellofemoral Pain Syndrome
Knee Pain
Lead sponsor: Aalborg University
Sponsor class: OTHER
Collaborators: name: Research Unit for General Practice in Aalborg
name: University of Southern Denmark
name: Copenhagen University Hospital, Denmark
First posted: 2016-08-19
Enrollment: 540
Sex: ALL
Minimum age (years): 15
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: In September 2011, students at 4 upper secondary schools in Aalborg were invited to answer an online questionnaire and to be part of the APA2011 cohort. From 2846 potential responders, 2200 adolescents responded to the questionnaire, corresponding to a response rate of 77%. A total of 504 adolescents indicating knee pain at least monthly were successfully contacted (a response rate of 83% of those who reported their telephone numbers) and were asked standardized questions on the telephone. This forms the cohort of 504 adolescents with knee pain. In addition a random selected group of adolescents without knee pain in 2011 will be contacted and asked the same questions as those with knee pain.

Brief summary: The prevalence of adolescent knee pain is 33%, and patellofemoral pain (PFP) is the most common diagnosis with a nontraumatic onset. The 5-year prognosis of adolescent PFP compared with other types of knee pain is unknown.

In 2011, a cohort of 2200 adolescents aged 15 to 19 years answered an online questionnaire on musculoskeletal pain. Of these, 504 reported knee pain, and 153 of these were clinically diagnosed with PFP. Now, after 5 years, the 504 adolescents, as well as 252 randomly selected adolescents who did not report knee pain in 2011, will be contacted again to gain insights into their prognosis.


Eligibility criteria: From the 504, 153 were diagnosed with PFP, the criteria for which included:

- insidious onset of anterior knee or retropatellar pain for longer than 6 weeks that was provoked by at least 2 of the following: prolonged sitting or kneeling, squatting, running, hopping, or stair climbing; tenderness on palpation of the patella; pain when stepping down; or double-leg squatting.

Exclusion criteria were:

* concomitant injury or pain from the hip, lumbar spine, or other knee structures
* self-reported patellofemoral instability
* knee joint effusion.

Primary outcomes:
measure: Knee pain during the last week
timeFrame: 5 years
Secondary outcomes:
measure: Knee pain during the last 30 days
timeFrame: 5 years
measure: Frequency of knee pain
timeFrame: 5 years
measure: When did your knee pain resolve
timeFrame: 5 years
measure: Pain in other regions of the body
timeFrame: 5 years
measure: Seeking medical attention for your knee pain
timeFrame: 5 years
measure: Previous treatments for your knee pain
timeFrame: 5 year
measure: Use of pain medication
timeFrame: 5 years
measure: Worst pain last week
timeFrame: 5 years
measure: Knee Injury and Osteoarthritis Outcome score
timeFrame: 5 years
measure: Health-related quality of life
timeFrame: 5 years
measure: The influence of knee pain on choice of activity level, mood, choice of education and professional career
timeFrame: 5 years
measure: Physical activity level
timeFrame: 5 years
measure: Number of sports participation per week
timeFrame: 5 years
measure: The effect of knee pain on sports participation
timeFrame: 5 years
measure: Self-reported sleep problems
timeFrame: 5 years
Other outcomes:
Locations:
Study officials:
References:
citation: Rathleff MS, Holden S, Straszek CL, Olesen JL, Jensen MB, Roos EM. Five-year prognosis and impact of adolescent knee pain: a prospective population-based cohort study of 504 adolescents in Denmark. BMJ Open. 2019 May 28;9(5):e024113. doi: 10.1136/bmjopen-2018-024113.