Clinical trial NCT06635603: HYPERTENSIVE CRISIS AND ATMOSPHERIC PRESSURE RELATIONSHIP
Official title: HYPERTENSIVE CRISIS AND ATMOSPHERIC PRESSURE RELATIONSHIP: A PROSPECTIVE STUDY
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Hypertensive Urgency
Weather
Keywords: atmospheric pressure
hypertension
hypertensive urgency
Lead sponsor: Saglik Bilimleri Universitesi
Sponsor class: OTHER
Collaborators: name: Etimesgut Military Hospital
First posted: 2024-10-10
Enrollment: 350
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients admitted to emergency department with hypertensive urgency ( systolic ≥180 and/or diastolic ≥110 mmHg )

Brief summary: relationship between the onset times of symptoms and the regions of patients presenting to the emergency department with hypertensive crisis (systolic ≥180 and/or diastolic ≥110 mmHg) and the fluctuations in atmospheric pressure

Detailed description: Hypertensive emergency is defined as grade 3 hypertension (systolic ≥180 and/or diastolic ≥110 mmHg) that causes end-organ damage, requiring urgent intervention and intensive care admission . Hypertensive crisis is described as severe hypertension not associated with end-organ damage. Some sources define hypertensive crisis as hypertension of grade 3 or higher, while others refer to it as severe hypertension without specifying a threshold .

Literature reviews, published guidelines, and studies indicate that the definitions and treatment approaches for hypertensive crisis differ between Europe and America, with variations in management from one physician to another . Seasonal blood pressure fluctuations are influenced by external temperature, indoor temperature, humidity, atmospheric pressure, and wind . Notably, during periods of low atmospheric pressure, blood pressure measurements show statistically significant increases compared to other days . Consequently, the frequency of life-threatening conditions associated with hypertension, such as intracranial hemorrhage and abdominal aortic aneurysm rupture, has been observed to increase on days when atmospheric pressure changes .

In our study, we aim to investigate the relationship between the onset times of symptoms and the regions of patients presenting to the emergency department with hypertensive crisis (systolic ≥180 and/or diastolic ≥110 mmHg) and the fluctuations in atmospheric pressure

Eligibility criteria: Inclusion Criteria:

1. Age 18 and above
2. Hypertensive crisis (systolic ≥180 and/or diastolic ≥110 mmHg)

Exclusion Criteria:

1. Patients presenting with hypertensive emergency (those with end-organ damage)
2. Patients who have traveled to another city or district within the last 4 days
3. Pregnant patients

Primary outcomes:
measure: Hypertensive Crisis
timeFrame: from enrollment to the end of follow up duration of 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Etlik City Hospital
Study officials:
affiliation: Ankara Etlik City Hospital
name: Gulsen AKCAY, ass. prof.
role: STUDY_DIRECTOR
References:
citation: Salvetti M, Paini A, Colonetti E, Tarozzi L, Bertacchini F, Aggiusti C, Stassaldi D, Rosei CA, Rosei EA, Muiesan ML. Hypertensive emergencies and urgencies: a single-centre experience in Northern Italy 2008-2015. J Hypertens. 2020 Jan;38(1):52-58. doi: 10.1097/HJH.0000000000002213.
citation: Jehn M, Appel LJ, Sacks FM, Miller ER 3rd; DASH Collaborative Research Group. The effect of ambient temperature and barometric pressure on ambulatory blood pressure variability. Am J Hypertens. 2002 Nov;15(11):941-5. doi: 10.1016/s0895-7061(02)02999-0.
citation: Modesti PA, Morabito M, Massetti L, Rapi S, Orlandini S, Mancia G, Gensini GF, Parati G. Seasonal blood pressure changes: an independent relationship with temperature and daylight hours. Hypertension. 2013 Apr;61(4):908-14. doi: 10.1161/HYPERTENSIONAHA.111.00315. Epub 2013 Feb 4.