Clinical trial NCT05890079: External Oblique Intercostal Plane Block for Liver Transplantation Donors
Official title: External Oblique Intercostal Plane Block for Postoperative Analgesia in Living Liver Donors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Liver Transplantation
Donor
Postoperative Pain
Lead sponsor: Istinye University
Sponsor class: OTHER
First posted: 2023-06-06
Enrollment: 64
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Postoperative pain management is one of the important factors to improve rehabilitation and enhance recovery. External oblique intercostal plane block may be used for abdominal wall analgesia to provide effective analgesia for abdominal surgery. The aim of this study is to investigate the postoperative analgesic efficacy of external oblique intercostal plane block and subcostal transversus abdominis plane block in living liver donors.

Researchers will compare the external oblique intercostal plane block group with subcostal transversus abdominis plane block to see if the external oblique intercostal plane block is effective for postoperative analgesia in living liver donors.

Detailed description: Patients scheduled for living donor hepatectomy will be separated into 2 groups: Subcostal Transversus Abdominis Plane Block Group and External Oblique Intercostal Plane Block Group. Patients in Subcostal Transversus Abdominis Plane Block will be performed subcostal transversus plane block at the end of the surgery and after skin closure and received patient controlled analgesia with morphine for postoperative analgesia. Patients in External Oblique Intercostal Plane Block Group will be performed bilateral External Oblique Intercostal Plane Block at the end of the surgery and after skin closure and received patient controlled analgesia with morphine for postoperative analgesia. Morphine consumption for first postoperative 24 hours, visual analog scale scores, time to need for first rescue analgesia, amount of rescue analgesic drug, incidence of postoperative nausea and vomiting will be recorded.

Eligibility criteria: Inclusion Criteria:

* Age between 18 and 75 years
* Patients with American Society of Anesthesiology (ASA) physical status I-II
* Patients scheduled for a living donor hepatectomy

Exclusion Criteria:

* Allergy to local anesthetics
* Coagulopathy
* Skin infection at the block area
* Advanced renal failure
* Chronic pain syndromes
* Alcohol or drug abuse
* Psychiatric disorders

Primary outcomes:
measure: Morphine consumption
timeFrame: Postoperative 24 hours
Secondary outcomes:
measure: Postoperative visual analog scale scores
timeFrame: Postoperative 24 hours
measure: Rescue analgesic drug consumption
timeFrame: postoperative 24 hours
measure: Incidence of postoperative nausea and vomiting
timeFrame: postoperative 24 hours
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istinye University Hospital
Study officials:
affiliation: Istinye University
name: Taylan Sahin, M.D.
role: PRINCIPAL_INVESTIGATOR
References: