Clinical trial NCT06859021: Validation of the HAR Score for Prioritization of Patients Calling the Emergency Medical Service for Chest Pain by Emergency Call Dispatcher
Official title: Validation of the HAR Score for Prioritization of Patients Calling the Emergency Medical Service for Chest Pain by Emergency Call Dispatcher : Reg-HAR Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Chest Pain
Keywords: Chestpain
HAR score
Emergency call
Lead sponsor: Centre Hospitalier le Mans
Sponsor class: OTHER
First posted: 2025-03-05
Enrollment: 796
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients calling center 15 for chest pain

Brief summary: The lifetime prevalence of chest pain in the general population is 20-40%. The etiologies to be evoked from the outset of management are those of cardiovascular origin, such as acute coronary syndrome (ACS) and pulmonary embolism. ACS is responsible for almost 20% of deaths. Delay in treatment is a major prognostic factor, given the importance of coronary reperfusion.

In France, one of the first contacts with the healthcare system is the medical regulation assistant (MRA) at the Centre 15. His or her role is to prioritize the call according to the identification of immediate signs of seriousness, and if necessary, to decide autonomously to send a rescue team before medical regulation. Depending on the reason for the call and any signs of seriousness, it prioritizes the call according to the expected response time. In line with current recommendations, all calls for chest pain should be answered by an emergency medical dispatcher (EMR) within 5 minutes. However, 60-90% of chest pain calls are not of cardiovascular origin. Their prioritization could therefore be re-qualified for longer response times.

Given the frequency of this type of call, a more efficient MRA referral strategy is needed. To achieve this, decision-support tools would be essential.

The performance of the HAR (History, Age and Risk Factors) score has been recently explored, derived from the HEART score, in a previous single-center prospective study in 2019. It stratifies the risk of a major cardiovascular event (MCE) into low (0 or 1 point), intermediate (2 or 3 points) or high (4, 5 or 6 points).

Investigator's hypothesis is that the HAR score could be entrusted to MRA, to enable them to optimize the prioritization of patients calling with non-traumatic chest pain, by qualifying low-risk chest pain calls on the one hand, which could be prioritized in P2 SNP, and high-risk calls on the other, making it possible to anticipate the dispatch of an emergency service.


Eligibility criteria: Inclusion Criteria:

* Patient of legal age (≥ 18 years)
* Calling Center 15 from 49, 72 or 37
* Expressing non-traumatic chest pain, even if this is not the main reason for seeking help.

Exclusion Criteria:

* Treatment in departments other than 49, 72 and 37
* Taken in charge in an emergency department of a private facility in the 49, 72 and 37 départements
* Poor understanding of the French language
* Non-affiliated or non-beneficiary of a social security scheme
* Person deprived of liberty by judicial or administrative decision
* Person under forced psychiatric care
* Person subject to a legal protection measure
* Person unable to express his/her non-opposition.
* Follow-up at Day 30 impossible for any reason
* Person having expressed his/her opposition to the collection of his/her data.

Primary outcomes:
measure: Number of major cardiovascular events
timeFrame: 30 days
Secondary outcomes:
measure: Performance of the HAR Score: Sensitivity, Specificity, and Comparison Between EMR and MRA
timeFrame: From Day 0 to Day 30
measure: Comparaison between rescue resources decided and predicted by the HAR score
timeFrame: From Day 0 to Day 30
measure: Time delta between the end of the MRA's score suggesting the dispatch of equipment (HAR score ≥ 4 points) and the actual decision to dispatch equipment in the current situation.
timeFrame: From Day 0 to Day 30
measure: Area under the ROC curve and Delong-Delong test
timeFrame: From Day 0 to Day 30
Other outcomes:
Locations:
city: Angers
country: France
facility: Centre Hospitalier Universitaire d'Angers
city: Le Mans
country: France
facility: Centre Hospitalier Le Mans
city: Tours
country: France
facility: CHRU de Tours
Study officials:
References: