louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06104384: Characteristics of Injury Claims by Chronic Pain Patients
Official title: Socio-demographics of Injury Insurance Claims by Chronic Pain Patients
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Social Functioning
Chronic Pain
Injuries
Disabilities Multiple
Keywords: Injury Claim
Disability Claim
Lead sponsor: Salem Anaesthesia Pain Clinic
Sponsor class: OTHER
First posted: 2023-10-27
Enrollment: 1000
Sex: ALL
Minimum age (years): 20
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult chronic pain patients who are undergoing treatment in a specialist pain clinic

Brief summary: Chronic pain is associated with injuries and disabilities. This prospective observational study explores the injury or disability claims made by chronic pain patients. It evaluates the socio-demographics of the patient population. It explores the impact of pain clinic services on the patients' injury rehabilitation, insurance claim outcome, and socioeconomic situation.

Detailed description: Chronic pain is associated with injuries, disabilities, psychological disorders, and unemployment. Chronic pain patients usually make insurance claims for injury, disability, and unemployment.

This prospective observational study explores the injury, disability, and compensation claims made by chronic pain patients. The study evaluates the socio-demographics of the patient population; including their gender, age, ethnicity, occupation, employment status, income, education level, family status, and home location. It explores the impact of pain clinic services on the patients' injury rehabilitation course, insurance claim outcome, and socioeconomic situation.

Eligibility criteria: Inclusion Criteria:

* adult chronic pain patients
* patients with injury claim

Exclusion Criteria:

* pediatric patients
* patients without injury claim

Primary outcomes:
measure: Percentage of patients who had injury insurance claims approved
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Surrey
country: Canada
facility: Salem Anaesthesia Pain Clinic
state: British Columbia
Study officials:
affiliation: Salem Anaesthesia Pain Clinic
name: Olumuyiwa Bamgbade, MD,FRCPC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01754584: The Effect and Mechanism of Hyaluronan on the Mucociliary Differentiation of Human Respiratory Epithelial Cells
Official title: The Effect and Mechanism of Hyaluronan on the Mucociliary Differentiation of Human Respiratory Epithelial Cells
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Respiratory System Defect
Keywords: hyaluronan including concentrations
molecular weight
mucociliary differentiation
human respiratory epithelial cells
Lead sponsor: Far Eastern Memorial Hospital
Sponsor class: OTHER
First posted: 2012-12-21
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: PATIENTS UNDERWENT SEPTOMEATOPLASTY

Brief summary: The mucociliary system of nasal mucosa, which is composed of the ciliated respiratory epithelium, the mucous blanket, and the mucus-producing glands, is an important defense component of the respiratory system. Therefore, it is important to maintain intact inner respiratory mucociliary epithelium in reconstruction of large respiratory defect and in the development of tissue engineering trachea. Hyaluronan derivatives, which are biodegradable and non-immunogenic, have already proved to be effective as a scaffold for chondrocytes. However, the feasibility of use as a scaffold for respiratory epithelial cells remained unexplored. The aim of the study is to investigate the effect of hyaluronan including concentrations and molecular weight on the mucociliary differentiation of human respiratory epithelial cells (HREC). If hyaluronan is able to promote mucociliary differentiation of HREC, the investigators can synthesize hyaluronan derivatives serving as ideal biomaterials for respiratory tissue engineering and tissue-engineered trachea in the future.


Eligibility criteria: Inclusion Criteria:

* PATIENTS UNDERWENT SEPTOMEATOPLASTY

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05588284: Preservation of Venous Valvular Function After PMT for Acute DVT
Official title: Effect of Endovascular Thrombectomy for Femoral Popliteal Vein Thrombosis on Venous Valve Function Maintenance: a Single-center, Single-arm Prospective Observational Study
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Acute Deep Venous Thrombosis of Femoral Vein (Disorder)
Lead sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Sponsor class: OTHER
Collaborators: name: Boston Scientific Corporation
First posted: 2022-10-20
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the venous valvular function after pharmacomechanical thrombectomy (PMT) for acute femoral-popliteal venous thrombosis.

Detailed description: All patients presenting with symptoms in the lower extremity due to the femoral venous thrombosis involving or not involving iliac and popliteal veins treated with percutaneously pharmacomechanical catheter-directed thrombolysis via AngioJet devices or anticoagulation alone were included in this study.

Eligibility criteria: Inclusion Criteria:

* Patients with acute symptomatic proximal DVT involving the femoral, and/or popliteal vein, common femoral vein, iliac veins (with or without other involved ipsilateral veins) were enrolled at seven vascular centers in China. Patients were treated with PCDT via Zelante device (Boston Scientific).

Exclusion Criteria:

* Participants were excluded if they had symptoms for more than 14 days.

Primary outcomes:
measure: Valvular reflux prevalence
timeFrame: at 12 months after procedure
Secondary outcomes:
measure: Cumulative Incidence of Post-Thrombotic Syndrome (Villalta Scale)
timeFrame: at 6, 12 and 24 months after procedure
measure: Patency rate of femopopliteal vein and iliofemoral vein
timeFrame: at 6, 12 and 24 months after procedure
Other outcomes:
Locations:
city: Chuzhou
country: China
facility: Chuzhou People's Hospital
state: Anhui
city: Shanghai
country: China
facility: Center hospital of Putu
state: Shanghai
city: Shanghai
country: China
facility: Central Hospital of Songjiang
state: Shanghai
city: Shanghai
country: China
facility: North Branch of Shanghai Ninth People's Hospital
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Ninth People's Hospital
state: Shanghai
city: Shanghai
country: China
facility: Fengchen Hospital
state: Shanghai
city: Taizhou
country: China
facility: Taizhou Municipal hospital
state: Zhejiang
Study officials:
affiliation: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
name: Kaichuang Ye, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01087684: Response to SLT vs. ALT in Patients Under 60 Years of Age
Official title: A Prospective, Randomized, Clinically Based Study on the Response to Selective Laser Trabeculoplasty Versus Argon Laser Trabeculoplasty in Patients Who Are Under 60 Years of Age
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Glaucoma
Keywords: Glaucoma
laser trabeculoplasty
intraocular pressure
Lead sponsor: Sunnybrook Health Sciences Centre
Sponsor class: OTHER
First posted: 2010-03-16
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Laser trabeculoplasty is a routine treatment for glaucoma and can be performed with either argon (ALT) or selective Yag (SLT) lasers. The effectiveness of each has not been studied in patients under 60 years, which is younger than average for the procedure. The study hypothesis is that there will be no difference between the two laser types.

Detailed description: Forty-two young patients (age 29 to 60) had one eye randomized to ALT (n = 22) or SLT (n = 20). Intraocular pressure was measured prior to laser and 1 hour, 1 day, 6 weeks, 3 months, every 3 months until 2 years, and then yearly post-laser. χ2 analysis and student's t-test were used to determine statistical significance.

Eligibility criteria: Inclusion Criteria:

* Age \< 60 years
* Intraocular pressure not adequately controlled

Exclusion Criteria:

* Prior laser treatment

Primary outcomes:
measure: Intraocular pressure
timeFrame: Two years
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Sunnybrook Health Sciences Centre
state: Ontario
Study officials:
affiliation: Sunnybrook Health Sciences Centre
name: Catherine M Birt, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Liu Y, Birt CM. Argon versus selective laser trabeculoplasty in younger patients: 2-year results. J Glaucoma. 2012 Feb;21(2):112-5. doi: 10.1097/IJG.0b013e318202791c.
Clinical trial NCT02060084: Effect of Early Oral Triple Viable Bifidobacterium Intestinal Flora in Preterm
Official title: Effect of Early Oral Triple Viable Bifidobacterium Intestinal Flora in Preterm
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Disorder of Stomach Function and Feeding Problems in Newborn
Feeding and Eating Disorders of Childhood
Keywords: preterm;
Intestinal flora;
early Micro-feeding
Feeding intolerance
Lead sponsor: Kunshan First People's Hospital Affiliated to Jiangsu University
Sponsor class: INDUSTRY
First posted: 2014-02-11
Enrollment: 60
Sex: ALL
Maximum age (years): 24
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Gut of newborn preterm is sterile, immediately by the mother and the surrounding environment from microbial colonization. As the effects of diet, intestinal flora is rapidly changed. Preterm children significantly delay in the establishment of normal flora,during hospitalization because of no breastfeeding, use of antibiotics, enteral feeding delay, combat disease and other factors. In this study, hospitalized preterm children for the study, the prospective randomized double-blind controlled study, to find oral intestinal bifidobacteria and lactobacilli and bifidobacteria subspecies composition and distribution, and further show intestinal bacteria in premature children case group.

Detailed description: Preterm infants are at high risk of deeding intolerance especially low birth weight infants, Whether oral triple viable Bifidobacterium and early Micro-feeding may improve the symptoms of feeding intolerance.

84 preterm infants BW(birth weight) less than 2.5kg,entered neonatal intensive care unit(NICU) less than 24 hours and meet the Inclusion Criteria of this study will be Randomly divided into three groups, control group、 treatment group1 (Triple viable Bifidobacterium 0.5g bid po)、treatment group2 （Triple viable Bifidobacterium 0.5g bid po and early micro-feeding）. treatment period for more than 1 week. For three groups, feeding symptoms,the traits and frequency of stool of 3 days,1 weeks,2 weeks.And the stool flora measured by PCR.

Eligibility criteria: Inclusion Criteria:

* preterm with birth weight \<2.5kg

Exclusion Criteria:

* Gastrointestinal bleeding and NEC,Kidney,liver function abnormal and have Serious congenital malformation

Primary outcomes:
measure: Intestinal flora
timeFrame: up to one week
Secondary outcomes:
measure: Feeding intolerance
timeFrame: up to one week
Other outcomes:
Locations:
city: Kunshan
country: China
facility: Kunshan First Hospital
state: Jiangsu
Study officials:
References:
Clinical trial NCT03046784: Non-invasive Haemodynamic Monitoring in Pregnancy
Official title: Non-invasive Haemodynamic Monitoring in Pregnancy : Comparison Between Ultrasound and Nexfin Technology
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pregnancy Related
Cardiac Output, High
Haemodynamic Instability
Lead sponsor: Hospital Nord
Sponsor class: OTHER
First posted: 2017-02-08
Enrollment: 55
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Non-labouring term pregmant women in their third trimester

Brief summary: This prospective and observational trial over 55 pregnant women (third trimester) compares non invasive haemodynamic monitoring using Nexfin technology and ultrasonography technic


Eligibility criteria: Inclusion Criteria:

* third trimester of pregnancy
* Non-labouring pregnant women
* accepting study

Exclusion Criteria:

* refusal of study
* first or second trimester of pregnancy

Primary outcomes:
measure: Cardiac output measure
timeFrame: 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Marseille
country: France
facility: Departement anesthesie reanimation hopital nord
Study officials:
References:
citation: Montenij LJ, Buhre WF, Jansen JR, Kruitwagen CL, de Waal EE. Methodology of method comparison studies evaluating the validity of cardiac output monitors: a stepwise approach and checklist. Br J Anaesth. 2016 Jun;116(6):750-8. doi: 10.1093/bja/aew094.
citation: Lee SW, Khaw KS, Ngan Kee WD, Leung TY, Critchley LA. Haemodynamic effects from aortocaval compression at different angles of lateral tilt in non-labouring term pregnant women. Br J Anaesth. 2012 Dec;109(6):950-6. doi: 10.1093/bja/aes349. Epub 2012 Oct 11.
Clinical trial NCT00042484: Community Organizing Network for Environmental Health
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Asthma
Keywords: Asthma
Children's Health
Community Based Research
Lead sponsor: National Institute of Environmental Health Sciences (NIEHS)
Sponsor class: NIH
First posted: 2002-08-01
Standard ages: CHILD
ADULT
OLDER_ADULT

Brief summary: The Community Organizing Network for Environmental Health is a part of Community Action Against Asthma (CAAA), which, in turn is a part of the Michigan Center for the Environment and Children's Health. It is a community-based intervention research partnership between the University of Michigan, community-based organizations, and health care institutions in Detroit.

Detailed description: The aims of the Community Organizing Network for Environmental Health are to:

* share with community groups and organizations the findings from data collected through household and air quality research of the CAAA project;
* identify and engage existing community groups and organizations interested in working on environmental issues important to their neighborhood and community in the hopes of creating an interorganizational network (I.N.);
* work with member group of the I.N. to organize, coordinate and conduct activities to reduce physical environmental threats related to asthma; and
* increase community awareness and knowledge of factors associated with the environment and asthma through sharing of findings to community residents through presentations, annual reports, postings of websites, and community forums


Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan School of Public Health
state: Michigan
Study officials:
References:
Clinical trial NCT02998684: Learning Enhancement Through Neurostimulation in Autism
Official title: Learning Enhancement Through Neurostimulation in Autism
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Autism
Keywords: Autism
Adolescent
Social skills
Lead sponsor: Medical University of South Carolina
Sponsor class: OTHER
Collaborators: name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
First posted: 2016-12-20
Enrollment: 25
Sex: ALL
Minimum age (years): 14
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will examine whether brain stimulation paired with social skills learning can help teenage boys with autism learn how to make and keep friends. Brain stimulation can enhance learning in some people. This study involves enrolling in a 14-week training program where teenage boys with autism interact in small groups and learn social skills. During the 14-week program participants will receive active brain stimulation, or non-active stimulation (placebo). Before and after this training, MRI scans will be taken to see whether the training with active brain stimulation made a different in brain activation.


Eligibility criteria: Inclusion Criteria:

* Autism Spectrum Disorder

Exclusion Criteria:

* Intellectual Disabilities (Full-scale IQ \<70)
* Hx of seizures within the last one year
* Contraindications for fMRI, such as metal implants in the head

Primary outcomes:
measure: Test of Adolescent Social Skills Knowledge (TASSK)
timeFrame: Baseline to 14-weeks
measure: Social Responsiveness Scale (SRS)
timeFrame: Baseline to 14 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Charleston
country: United States
facility: Medical Univeristy of South Carolina
state: South Carolina
Study officials:
affiliation: Medical University of South Carolina
name: Jane Joseph, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03309384: Intraoperative Monitoring to Predict Postoperative Complications After Thyroidectomy
Official title: Intraoperative Monitoring (Parathormone Values and Continuous Neuromonitoring) to Predict Postoperative Complications After Total Thyroidectomy
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Endocrine Procedural Complications
Thyroid
Parathyroid; Deficiency
Laryngeal Injury
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2017-10-13
Enrollment: 1000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients scheduled for total thyroidectomy in university of Nancy (University Hospital)

Brief summary: The goal of this study is to evaluate the role of intraoperative continous and intermittent neuromonitoring and intraoperative parathormone (PTH) to predict postoperative nerve morbidity and hypocalcemia.

Detailed description: Intraoperative PTH values and intraoperative continuous neuromonitoring will be collected prospectively in consecutive patients who undergo total thyroidectomy.

Postoperative parathyroid morbidity and recurrent laryngeal nerve morbidity will be evaluated within 1 week after total thyroidectomy and at 1 year postoperatively.

Other postoperative morbidity will be evaluated at 1 year postoperatively using validated classification.

Eligibility criteria: Inclusion Criteria:

* patients scheduled for total thyroidectomy in university of Nancy (University Hospital)

Exclusion Criteria:

* refusal to participate

Primary outcomes:
measure: intraoperative parathormone values
timeFrame: intraoperative
Secondary outcomes:
measure: postoperative hypocalcemia
timeFrame: within 1 week after thyroidectomy
measure: postoperative hypoparathyroidism
timeFrame: within 1 week after thyroidectomy
measure: permanent postoperative hypocalcemia
timeFrame: at one year after thyroidectomy
measure: permanent postoperative hypoparathyroidism
timeFrame: at one year after thyroidectomy
measure: laryngeal nerve palsy
timeFrame: during thyroidectomy
measure: laryngeal nerve palsy
timeFrame: within 1 week after thyroidectomy
measure: laryngeal nerve palsy
timeFrame: at one year after thyroidectomy
measure: Postoperative complications other than outcomes from 1 to 8
timeFrame: at one year after thyroidectomy
Other outcomes:
Locations:
city: Vandœuvre-lès-Nancy
country: France
facility: CHU Nancy
Study officials:
affiliation: CHU NANCY
name: Brunaud
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01234584: Soft and Hard Tissue Changes Around the New Lance® Implants Using Traditional and Switch Platform Abutments
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Group A- 23 Implant Using Switch Platform -SPK Abutment.
Group B- 22 Implant Using the Traditional -CPK Abutment.
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2010-11-04
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this present study is to compare alveolar bone changes and markers of gingival health around the new Lanes® dental implant which were rehabilitate using the new switch platform abutment ( SPR ) and the traditional ( CPK ) abutment.


Eligibility criteria: Inclusion Criteria:

1. Adult patient aged 18 - 80 yrs.
2. Implants treatment planned for single crown rehabilitation.
3. Submerged implant placement.
4. Patients willing to participate in a twelve month study.
5. Up to 2 implants per patient will be allowed.

Exclusion Criteria:

1. Active periodontal disease.
2. Systemic condition and medication that may affect soft and hard tissue healing.
3. Pregnancy or intention to become pregnant in the next twelve months.
4. Parafunctional occlusal scheme and habits.

Primary outcomes:
measure: Soft tissue evaluation:
timeFrame: 12 month
measure: Radiographic evaluation:
timeFrame: 12 month post surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Department of Maxillofacial Rehabillitaion School of Graduate Dentistry Rambam Health care campus
Study officials:
References:
Clinical trial NCT00587184: Confocal Microscopy in Barrett's Esophagus
Official title: The Use of Confocal Microscopy in Barrett's Esophagus
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Barrett's Esophagus
Keywords: Barrett's Esophagus
Confocal Microscopy
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2008-01-07
Enrollment: 92
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who have had confocal microscopy imaging in patients at the time of or clinically indicated endoscopic surveillance and biopsies of BE.

Brief summary: This data review will be done to evaluate the use of confocal microscopy imaging in patients who were seen for clinically indicated endoscopic surveillance and biopsies of Barretts Esophagus

Detailed description: This retrospective chart review will be done to evaluate the use of confocal microscopy imaging in patients who were seen at Mayo Clinic for clinically indicated endoscopic surveillance and biopsies of BE.

Endoscopy reports and pathology results will be reviewed from 100 patients who have undergone endoscopy. These results will be correlated with images obtained with confocal microscopy at the time of the endoscopy. There will be no patient contact.

Eligibility criteria: Inclusion Criteria:

* Patients who have undergone confocal microscopy at the time of surveillance endoscopy for Barrett's Esophagus

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Kenneth K Wang, MD
role: PRINCIPAL_INVESTIGATOR
References: