Clinical trial NCT05020301: Investigation of Functional Brain Network in Altered Meditation State With Multimodal Neuroimaging
Official title: Investigation of Functional Brain Network in Altered Meditation State With Multimodal Neuroimaging
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Meditation
Mindfulness
Keywords: mindfulness
functional brain network
neuroimaging
meditation
Lead sponsor: Shanghai Mental Health Center
Sponsor class: OTHER
Collaborators: name: School of Biomedical Engineering, Shanghai Jiao Tong University
First posted: 2021-08-25
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study is to investigate functional brain network in altered meditation state with multimodal neuroimaging.

Detailed description: 1. Recruiting participants by approaching mindfulness training, poster, and websites.
2. Completing Questionnaires, Tests, and other materials for experiments.
3. Examining Functional Brain Network of Internal and External Meditation of practitioners with a meditation using multimodal neuroimaging.
4. Collecting and evaluating data about the connection of internal and external meditation with multimodal neuroimaging and identifying the function related to meditation state.

Eligibility criteria: Inclusion Criteria:

* A sufficient level of education to understand study procedure and be able to communicate with site personnel.
* 18-60 years old.
* Interested in meditation.
* No metal or electronic implants in the body; no prosthesis (metal braces, dentures, etc.); no claustrophobia; no tattoos, piercings, etc.; no makeup on the day of the experiment.
* Right-handed.

Exclusion Criteria:

* The participant has a contraindication to MRI examination, such as claustrophobia.
* The participant is physically unfit for MRI, such as having a metal implant.
* The participant has a history of neurological or psychiatric disorders, or is taking any chronic medications that may interfere with the experiment.

Primary outcomes:
measure: Mindfulness positive awareness examined by Mindful Attention Awareness Scale (MAAS), Five Facet Mindfulness Questionnaire(FFMQ), The Chinese version of Freiburg Mindfulness Inventory(FMI-13) after the 1-week practice of internal and external mindfulness
timeFrame: Week 2
measure: The mental states examined by Brief Profile of Mood States(Brief-POMS), Perceived Stress Scale(PSS) after the 1-week practice of internal and external mindfulness
timeFrame: Week 2
measure: Cognitive impairment quantitative assessment by Mini-Mental State Examination(MMSE)
timeFrame: Week 2
measure: The cognitive flexibility examined by Cognitive Flexibility Inventory(CFI) after the 1-week practice of internal and external mindfulness
timeFrame: Week 2
measure: The ability of self-compassion examined by Self-Compassion Scale(SCS) after 1-week practice of internal and external mindfulness
timeFrame: Week 2
measure: Intelligence assessment by Raven's Standard Progressive Matrices (SPM)
timeFrame: Week 2
measure: Mental flexibility assessment by Trail Making Test (TMT)
timeFrame: Week 2
measure: CSF pulsation index
timeFrame: Week 2
measure: Functional connectivity
timeFrame: Week 2
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: School of Biomedical Engineering, Shanghai Jiao Tong University
state: Shanghai
Study officials:
affiliation: Shanghai Mental Health Center
name: Qing Fan
role: STUDY_CHAIR
affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University
name: Jie Luo
role: STUDY_CHAIR
References: