louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02863484: Cavernous Sinus Dissection and Bleeding in Meningiomas
Official title: Dissection of the Outer Layer of the Lateral Wall of the Cavernous Sinus Decreases Bleeding as Compared to Direct Tumor Attack in Middle Fossa Meningiomas: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Meningiomas of the Middle Cranial Fossa
Lead sponsor: Kasr El Aini Hospital
Sponsor class: OTHER
First posted: 2016-08-11
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The blood loss will be compared in middle fossa meningiomas which will receive pealing of the outer layer of the lateral wall of the cavernous sinus and those which will not revive pealing before the dura is opened

Detailed description: Cases with middle fossa meningiomas will be randomised to one of two surgical techniques. The first technique will involve pealing of the outer layer of the lateral wall of the cavernous sinus before the dura is opened and the tumour attacked, and the second group of cases will be operated by a standard technique, where the tumour will be directly attacked with out pealing of the outer layer of the lateral wall of the cavernous sinus. Blood loss will be monitored in each case by calculating the amount of blood in the suction container and subtracting it from the amount of fluids used for irrigation during surgery. The number of cotton patties and dressings will be also counted with each case as well as the number of gauzes used. The pre-operative complete blood picture will be documented particularly the haemoglobin , hematocrits and others. The same lab data will be also monitored after surgery. The amount of blood transfusion required will also be calculated in each case.

Eligibility criteria: Inclusion Criteria:

* Meningiomas of the middle cranial fossa

Exclusion Criteria:

* Meningiomas outside the middle cranial fossa

Primary outcomes:
measure: Amount of blood loss as estimated by cubic centimetres during surgery
timeFrame: three months
Secondary outcomes:
measure: Radically of surgery as estimated by post-operative tumour volume in cubic centimetres on post-operative MRI
timeFrame: 3 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Kasralainy medical college, Cairo University
state: Greater Cairo
Study officials:
affiliation: Professor of neurosurgery, faculty of medicine, Cairo University
name: Ahmed Hegazy, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06989684: Implant Stability Changes Using Underdrilling Versus Osseodensification Protocols for Posterior Dental Implants
Official title: Implant Stability And Changes In Ridge Width Using Underdrilling Versus Osseodensification Protocols For Posterior Dental Implant- A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Dental Implant Stability
Keywords: secondary implant stability
Lead sponsor: Postgraduate Institute of Dental Sciences Rohtak
Sponsor class: OTHER
First posted: 2025-05-25
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This clinical trial aims to compare two drilling protocols Underdrilling and Osseodensification for placing dental implants in patients with low bone density. The purpose is to compare which technique provides better primary and secondary implant stability in the posterior regions of the jaw with low bone density. The hypothesis is that there is no significant difference in implant stability between the two protocols.

Detailed description: Achieving sufficient primary stability becomes difficult in areas with low bone density. One technique commonly used is Underdrilling protocol.With the Underdrilling technique, the final osteotomy is smaller than the diameter of the implant to be placed.A relatively new Osseodensification protocol, introduced by Huwais in 2013, employs specially designed bur that smoothly compact the bone as they expand an osteotomy. This may prove to be particularly helpful in cases with low bone quality.This clinical trial aims to compare the implant stability using these drilling protocols

Eligibility criteria: Inclusion Criteria:

1. Patient partially edentulous ridge after extraction of more than 6 months and with low bone density.
2. Systemically healthy patients ≥18 years of age.

Exclusion Criteria:

1. Smokers.
2. Pregnant or lactating females.
3. Uncontrolled systemic disease like diabetes, hypertension, hormonal therapy and hematologic diseases.
4. History of Maxillary sinus pathology.

Primary outcomes:
measure: Implant stability
timeFrame: 12-18 months
Secondary outcomes:
Other outcomes:
Locations:
city: Rohtak
country: India
facility: PGIDS
state: Haryana
Study officials:
affiliation: PGIDS,Rohtak
name: Dr.Ritika Arora, MDS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02901002: Body Perception and Complex Regional Pain Syndrome
Official title: Body Perception and Complex Regional Pain Syndrome : a Case-control Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Complex Regional Pain Syndromes
Keywords: Complex Regional Pain Syndromes
Pain
Spontaneous sensations
interoception
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2016-09-15
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients suffering from CRPS of the lower limb and Healthy controls

Brief summary: In CRPS, perturbation of body image and pseudo-neglect syndrome of the body part affected are frequently found. Pain and sensory perturbation seems to modify the way patients perceived their body part affected.

Does a local body image perturbation can affect the balanced of the global self-awareness?

Detailed description: With the investigation of spontaneous sensations (SPS) according to the protocol of Michael and al (2011) the investigators study how patients can listen to their internal sensations located in other body part than the painful member in order to construct a representation of the body and maintain it in active consciousness. A group of controls will be included to understand if there is a global modification in the perception of SPS witch may be linked to the pathology.

Eligibility criteria: Inclusion Criteria:

* For patients:

  • a diagnosis of CRPS of the lower limb according to the Budapest Criteria (men or women) For patients and control group
* Age ≥ 18 years

Exclusion Criteria:

For patients and control group

* neurological disease with cerebral repercussion or not stabilized serious physical illness;
* psychotropic medication
* disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

  * For patients:
* Presence of an other pain disorder

Primary outcomes:
measure: Sensory testing
timeFrame: day 1
Secondary outcomes:
measure: Neurological evaluation by questionary
timeFrame: day 1
Other outcomes:
Locations:
city: Saint-Etienne
country: France
facility: CHU Saint-Etienne
Study officials:
affiliation: CHU SAINT-ETIENNE
name: Christelle CREAC'H, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04771702: Expired Propofol in Low Back Surgery
Official title: Propofol Measurement in Expiration Air and Monitoring of EEG and Pain in Patients Undergoing Low Back Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Anesthesia
Lead sponsor: Oslo University Hospital
Sponsor class: OTHER
First posted: 2021-02-25
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: The intervention is to have patients in 20 min stable anaesthesia before start of surgery in order to validate the use of exhaled propofol versus pharmakokinetic modelling and measured plasma concentration
Primary purpose: DIAGNOSTIC

Brief summary: Edmon (BBraun, Germany) is a portable, commercially available device for measurement of propofol in exhaled air.

The study will aim at evaluating the sensitivity and specificity of such exhaled propofol values compared with plasma propofol and measures of anaesthetic and antinociceptive effect.

Detailed description: Elective low-back surgery patients will be induced for general intubation anesthesia with propofol and remifentanil.

After induction a 20 min period of stable propofol infusion only will be established before start of surgery. The patients will be monitored for exhaled propofol, plasma propofol (blood samples), continous frontal EEG, Bispectral Index (BIS), skin conductance, estimated (computer based) concentrations of plasma and effect site propofol, and skin conductance.

After start of surgery (with ongoing propofol and restart of remifentanil TCI) the monitoring will continue in order to explore these relationships further.

Eligibility criteria: Inclusion Criteria:

* Elective patients scheduled for low-back surgery
* BMI between 20 -32 kg/m2
* ASA I-II
* Written informed concent

Exclusion Criteria:

* Contraindication to propofol TCI
* Use of psychopharmaco or neurologic disease
* Pregnancy or breast feeding

Primary outcomes:
measure: Exhaled air versus plasma concentration
timeFrame: per-operative
Secondary outcomes:
measure: EEG recording
timeFrame: per-operative
measure: Exhaled propofol 2
timeFrame: per-operative
measure: Nociceptive stimulation
timeFrame: per-operative
Other outcomes:
Locations:
city: Oslo
country: Norway
facility: Dept of Anesthesiology, Oslo University Hospital, Ullevaal
Study officials:
affiliation: Oslo University Hospital
name: Kristin S Thagaard, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03146702: Turkish Translation of The Emphasis-10 Questionnaire
Official title: Evaluation of the Validity and Reliability of the Turkish Translation of The Emphasis-10 Questionnaire in Patients With Pulmonary Hypertension
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pulmonary Hypertension
Keywords: Quality of Life
Lead sponsor: Istanbul University
Sponsor class: OTHER
First posted: 2017-05-10
Enrollment: 101
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Investigators include Pulmonary Hypertension patients who is following at least 6 months by the pulmonary hypertension policlinic. Patients had to be native turkish to newly translated EmPHasis-10 questionnaire to be valid. Patients who have cognitive impairment and difficulty understanding or speaking Turkish are excluded.

Brief summary: Pulmonary Hypertension (PH) is a hemodynamic and physiopathological condition that is defined as an increase in mean pulmonary artery pressure ≥25 mmHg when measured at rest. PH often progresses to heart failure and premature deaths. PH is a progressive disease that has many causes, which can affect people of all ages, is characterized by shortness of breath, reduced exercise tolerance, psychological distress and tiredness and reduced quality of life. Surveys of SF-36, 'Nottingham Health Profiles' and 'Minnesota Life with Heart Failure' surveys are routinely performed in PH clinically. However, none of the questionnaires are specific to pulmonary hypertension, so they are incomplete in determining the condition of the disease and the patients. There is no Turkish questionnaire for patients with pulmonary hypertension and other surveys used are inadequate in determining the condition of the patient and the patient since they are not specific to the disease. The aim is to provide a Turkish questionnaire that is specific to pulmonary hypertension in the literature.


Eligibility criteria: Inclusion Criteria:

* Have been diagnosed with Pulmonary Hypertension
* Following at least 6 months of Pulmonary Hypertension policlinic
* Native Turkish
* People age 18 years or older

Exclusion Criteria:

* Those with cognitive impairment
* Those who have difficulty understanding or speaking Turkish

Primary outcomes:
measure: Validity
timeFrame: 8 months
measure: Reliability
timeFrame: 8 months
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Istanbul University
Study officials:
affiliation: Istanbul University
name: Pınar Odevoglu, MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04737902: ESP Block, CNP and QoL After VATS
Official title: Erector Spinae Plane (ESP) Block, Incidence of Chronic Neuropathic Pain (CNP) and Quality of Life (QoL) After VATS. An Observational Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Pain
Video-assisted Thoracoscopic Surgery
Keywords: regional anesthesia
postoperative pain
video-assisted thoracoscopic surgery
erector spinae plane block
Neuropathic Pain
Quality of Life
Lead sponsor: Hospital Universitario San Ignacio
Sponsor class: OTHER
First posted: 2021-02-04
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Primary care clinic

Brief summary: The Erector Spinae Plane Block (ESPB) is an adequate alternative for pain management after video-assisted thoracoscopy surgery (VATS). The incidence of postoperative chronic neuropathic pain (CNP) and the quality of life (QoL) in patients with ESPB after VATS remain unknown. We hypothesised that patients with ESPB would have a low incidence of acute and CNP and would report a good QoL up to three months after VATS.

Detailed description: We, therefore, performed this prospective observational study. The a priori primary outcome was incidence of CNP three months postoperatively (POP) in patients undergoing VATS surgery with ESPB as the regional anaesthesia technique. The secondary outcome was to describe pain control at PACU, 12 and 24 hours POP and QoL reported up to three months after surgery. We hypothesised that patients with ESPB would have a low incidence of acute and CNP and report a good QoL.

Eligibility criteria: Inclusion Criteria:

* patients who underwent VATS and required at least one day of hospital stay after surgery

Exclusion Criteria:

* patients with mental or physical limitation to answer the questionnaires.
* patients who required mechanical ventilation.
* patients who required surgery conversion to thoracotomy.
* patients who declined consent.

Primary outcomes:
measure: Incidence of chronic neurophatic pain
timeFrame: 3 month
Secondary outcomes:
measure: Postoperative pain
timeFrame: 24 hours
measure: Quality of Life POP
timeFrame: 3 months POP
Other outcomes:
Locations:
city: Bogota
country: Colombia
facility: Hospital Universitario
state: Cundinamarca
Study officials:
affiliation: Hospital Universitario San Ignacio
name: Lorena Díaz-Bohada, MD, MSc
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bayman EO, Parekh KR, Keech J, Selte A, Brennan TJ. A Prospective Study of Chronic Pain after Thoracic Surgery. Anesthesiology. 2017 May;126(5):938-951. doi: 10.1097/ALN.0000000000001576.
citation: Forero M, Adhikary SD, Lopez H, Tsui C, Chin KJ. The Erector Spinae Plane Block: A Novel Analgesic Technique in Thoracic Neuropathic Pain. Reg Anesth Pain Med. 2016 Sep-Oct;41(5):621-7. doi: 10.1097/AAP.0000000000000451.
Clinical trial NCT03073902: The Correlation of PD-L1 Expression in Non-small Lung Cancer Tissue and Peripheral Blood T Cell and Serum.
Official title: Clinical Research for the Correlation of PD-L1 Expression in Non-small Lung Cancer Tissue and Peripheral Blood T Cell and Serum.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: NSCLC
Lead sponsor: Xinqiao Hospital of Chongqing
Sponsor class: OTHER
First posted: 2017-03-08
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pathological histology and/or cytology confirmed non-small lung cancer

Brief summary: The detection of tissue PD-L1 immunohistochemistry in Non-small cell lung cancer (NSCLC) has an important role in guiding for the treatment of immune detection point. At the same time,tissue detection is time-consuming and laborious, liquid biopsy can reflect the information of tumor tissue,PD-L1 expression in serum and peripheral blood T cell are expected to be simple, rapid, non-invasive means of detection. The project is planned to explore the correlation of PD-L1 expression in non-small lung cancer tissue and peripheral blood T cell and serum..The investigators have designed to detected the expression levels of PD-L1 protein in cancer tissue and detected the expression levels of PD-L1 in peripheral blood T cell and serum.By using variance analysis of repeated measures design information. Thus exploring the correlation of PD-L1 expression in non-small lung cancer tissue and peripheral blood T cell and serum,guiding clinical practice of immunotherapy.


Eligibility criteria: Inclusion Criteria:

1. Pathological histology and/or cytology confirmed non-small lung cancer;
2. Voluntarily enrolled to participate in,better compliance, cooperate with experimental observations, and sign informed consent.

Exclusion Criteria:

1. Vital organs (e.g., heart, liver, kidney) have serious dysfunction;
2. Patients with a history of autoimmune disease;
3. Patients with participating in other clinical trials at the same time;
4. Other cases that researchers believe that patients should not participate in the present trial.

Primary outcomes:
measure: The match rate of PD-L1 protein expression in non-small lung cancer tissue and peripheral blood T cell .
timeFrame: up to two years
measure: The match rate of PD-L1 protein expression in non-small lung cancer tissue and serum.
timeFrame: up to two years
Secondary outcomes:
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Xinqiao Hospital of Chongqing
Study officials:
References:
Clinical trial NCT01728402: Pathogenesis of Hematologic Malignancies
Official title: Pathogenesis of Acute Leukemia, Lymphoproliferative Disorders, and Myeloproliferative Disorders
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Acute Leukemia
Lymphoproliferative Disorders
Myeloproliferative Disorders
Myelodysplastic Syndromes
Lead sponsor: OHSU Knight Cancer Institute
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
name: National Cancer Institute (NCI)
First posted: 2012-11-19
Enrollment: 5000
Sex: ALL
Minimum age (years): 1
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients of any age with a diagnosis or suspected diagnosis of a blood or bone marrow cancer may be a part of this study. The provider who will perform the blood draw, bone marrow aspirate, or biopsy as part of the patient's routine care will identify possible participants from their clinic schedule or patient list, give them information about what would be involved in participating in the study including possible risks, and ask if they are interested in participating.

Brief summary: The cause of blood and bone marrow cancers is poorly understood; however, most research focuses on how cancer cells grow and develop. Because the causes of these cancers are unknown, current treatments may be unnecessarily harsh and often do not provide a cure. Identifying the causes of blood cancers would allow for the development of treatments that are more likely to provide a cure. To find the causes of blood and bone marrow cancers, we will look for specific cancer cell abnormalities that are responsible for cancer cell growth. We will then look to see if drugs that can reverse these abnormalities can kill cancer cells.


Eligibility criteria: Inclusion Criteria:

* Suspected or confirmed diagnosis of AL, LPD, MDS, or MPD
* Male or female of all ages
* Willing and able to sign informed consent
* Willing guardian consent for participants under 18 years of age

Exclusion Criteria:

* No suspected or confirmed diagnosis of acute leukemias (AL), lymphoproliferative disorders (LPD), myelodysplastic syndromes (MDS), or myeloproliferative diseases (MPD)

Primary outcomes:
measure: Identify and determine the frequency of mutations causing aberrant signaling pathway function in patients with acute leukemias (AL), lymphoproliferative disorders (LPD), myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPN)
timeFrame: After laboratory analyses are complete. Lab samples are collected at the time of a scheduled blood draw, bone marrow procedure, tissue biopsy, or other visit for usual medical care
Secondary outcomes:
Other outcomes:
Locations:
city: Portland
country: United States
facility: OHSU Knight Cancer Institute
state: Oregon
Study officials:
affiliation: OHSU Knight Cancer Institute
name: Marc Loriaux, MD
role: PRINCIPAL_INVESTIGATOR
References: