Clinical trial NCT02482181: Diffusion Weighted Magnetic Resonance Imaging for the Characterization of Solitary Pulmonary Lesions
Official title: Diffusion Weighted Magnetic Resonance Imaging for the Characterization of Solitary Pulmonary Lesions
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Thorax Cancer
Keywords: diffusion weighted magnetic resonance imaging
Lead sponsor: Trakya University
Sponsor class: OTHER
First posted: 2015-06-26
Enrollment: 46
Sex: ALL
Minimum age (years): 20
Maximum age (years): 78
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Magnetic resonance imaging (MRI) was applied to a total of 46 patients between January 2011 and July 2011, who presented.

Brief summary: The purpose of this study, is to investigate the value of diffusion weighted imaging on the differential diagnosis of solitary pulmonary lesions.

Detailed description: When a patient is diagnosed with a lung lesion, the differential diagnosis is important, since the treatment is determined by the lesion character. The goal in the evaluation of solitary pulmonary lesions is to distinguish malignant lesions from benign lesions in as non-invasive a manner as possible. As computed tomography is widely used, the diagnosis of solitary pulmonary lesions has become easier. The size, features of the edges, shape, internal structure (calcification, fat content, cavitation, etc.), density, satellite nodule, growth rate and contrast involvement of the lesion are important properties which help to distinguish benign lesions from malignant ones. However, as the distinction is not absolute at all times, other imaging methods such as positron emission tomography and magnetic resonance are preferred. The importance of this issue is the high five-year survival rate in early-diagnosed lung cancer cases.

Diffusion is the randomized microscopic motion of water molecules. It is known that diffusion is a sensitive parameter of tissue characterization at a microscopic level. Nowadays, diffusion is measured in vivo with diffusion weighted MRI and ADC measurements.

Diffusion weighted imaging has a wide use on oncologic patients for the purpose of diagnosis. In addition, it is used in the distinction of acute cerebral infarction and epidermoid or arachnoid cysts. Recently, it has also been used in the characterization of cystic or solid lesions in the thoracic cavity. In this study, the investigators aimed to evaluate the accuracy of differentiation of solitary pulmonary lesions.

Eligibility criteria: Inclusion Criteria:

* All patients had a solitary pulmonary nodule or mass.

Exclusion Criteria:

-

Primary outcomes:
measure: On diffusion weighted images, the signal intensities of the lesions were visually compared to the SI of the thoracic spinal cord using a 5-point scale.
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Edi̇rne
country: Turkey
facility: Trakya University Hospital
Study officials:
affiliation: TURKEY,EDİRNE ,TRAKYA UNİVERSİTY HOSPİTAL
name: HAKAN GENÇHELLAÇ, MD
role: STUDY_DIRECTOR
References:
citation: Cakir C, Genchellac H, Temizoz O, Polat A, Sengul E, Duygulu G. Diffusion Weighted Magnetic Resonance Imaging for the Characterization of Solitary Pulmonary Lesions. Balkan Med J. 2015 Oct;32(4):403-9. doi: 10.5152/balkanmedj.2015.15663. Epub 2015 Oct 1.