Clinical trial NCT01011738: An Observational Cohort Study in Patients With Chronic Hepatitis B Receiving Pegasys
Official title: A Multicenter, Prospective, Observational, Non-Interventional Cohort Study Evaluating On-Treatment Predictors of Response in Subjects With HBeAg Positive and HBeAg Negative Chronic Hepatitis B Receiving Therapy With PEGASYS(R) (Peginterferon Alfa-2a 40KD)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hepatitis B, Chronic
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2009-11-11
Enrollment: 1842
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with chronic hepatitis C receiving treatment with peginterferon alfa-2a 40KD (Pegasys)

Brief summary: This observational, non-interventional cohort study will evaluate predictors of response in patients with chronic hepatitis B receiving standard of care Pegasys therapy. Efficacy and safety parameters will also be evaluated. Patients included in the study will be followed for the duration of their treatment and for up to 3 years thereafter.


Eligibility criteria: Inclusion Criteria:

* adult patient, \>/= 18 years of age
* chronic hepatitis B
* treatment with peginterferon alfa-2A

Exclusion Criteria:

* coinfection with HAV, HCV and HIV

Primary outcomes:
measure: Percentage of Participants With Hepatitis B Virus Surface Antigen Clearance
timeFrame: Up to 276 Weeks
measure: Predictive Values of Early on Treatment Response for Hepatitis B Surface Antigen Clearance 3 Years Post-Treatment- Hepatitis B Virus e Antigen Positive Participants
timeFrame: Up to 276 Weeks
measure: Predictive Values of Early on Treatment Response for Hepatitis B Surface Antigen Clearance 3 Years Post-Treatment- Hepatitis B Virus e Antigen Negative Participants
timeFrame: Up to 276 Weeks
Secondary outcomes:
measure: Percentage of Participants With Suppression of Hepatitis B Virus Deoxyribonucleic Acid to <2,000 International Units Per Milliliter
timeFrame: Up to 276 Weeks
measure: Percentage of Participants With Hepatitis B Virus e Antigen Seroconversion in Hepatitis B Virus e Antigen Positive Participants
timeFrame: Up to 276 Weeks
measure: Percentage of Participants With Hepatitis B Virus e Antigen Loss in Hepatitis B Virus e Antigen Positive Participants
timeFrame: Up to 276 Weeks
measure: Percentage of Participants With Hepatitis B Virus e Antigen Seroconversion and Hepatitis B Virus Deoxyribonucleic Acid <2000IU/mL in Hepatitis B Virus e Antigen Positive Participants
timeFrame: Up to 276 Weeks
measure: Percentage of Participants With Hepatitis B Surface Antigen Seroconversion
timeFrame: Up to 276 Weeks
measure: Quantitative Hepatitis B Surface Antigen
timeFrame: Up to 276 Weeks
measure: Percentage of Participants With Normalization of Alanine Transaminase
timeFrame: Up to 276 Weeks
measure: Alanine Transaminase Ratio Over Time by Hepatitis B Virus e Antigen Status
timeFrame: Up to 276 Weeks
measure: Number of Participants With Chronic Hepatitis B - Associated Clinical Endpoints- Liver Transplantation, Hepatocellular Carcinoma, and Liver Decompensation
timeFrame: Up to 276 Weeks
measure: Number of Participants With Chronic Hepatitis B Associated Clinical Endpoints- Liver Cirrhosis
timeFrame: Up to 276 Weeks
measure: Number of Participants With Serious Adverse Drug Reactions
timeFrame: Up to 276 Weeks
measure: Number of Participants With Non-Serious Adverse Drug Reactions
timeFrame: Up to 276 Weeks
measure: Number of Participants With Adverse Events and Serious Adverse Events
timeFrame: Up to 276 Weeks
measure: Number of Deaths During Observation Period
timeFrame: Up to 276 Weeks
Other outcomes:
Locations:
city: Graz
country: Austria
facility: Lkh-Univ. Klinikum Graz
city: Innsbruck
country: Austria
facility: Tiroler Landeskrankenanstalten Ges.M.B.H.; Klinische Abt. Für Gaströnterologie & Hepatologie
city: Linz
country: Austria
facility: A.Ö. Krankenhaus Der Elisabethinen Linz; Iv. Med. Abtl.
city: Wien
country: Austria
facility: Medizinische Universität Wien; Univ.Klinik für Innere Medizin III - Gastroenterologie & Hepatologie
city: Wien
country: Austria
facility: Wilhelminenspital; Iv. Medizinische Abt.
city: Manama
country: Bahrain
facility: Salmaniya Medical Complex; Gastroenterology
city: Dhaka
country: Bangladesh
facility: Liver Clinic Lab-Aid Specialized Hospital
city: Dhaka
country: Bangladesh
facility: The Liver Centre
city: Banja Luka
country: Bosnia and Herzegovina
facility: Clinical Center Banja Luka; Department for Infective Diseases
city: Bihac
country: Bosnia and Herzegovina
facility: Cantonal Hospital Bihac; Department for Infective Diseses
city: Mostar
country: Bosnia and Herzegovina
facility: Clinical Hospital Mostar; Department for Gastroenterology
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center Sarajevo; Gastroenterohepatology
city: Tuzla
country: Bosnia and Herzegovina
facility: University Clinical Center Tuzla; Clinic for Gastroenterology
city: Tuzla
country: Bosnia and Herzegovina
facility: University Clinical Center Tuzla; Clinic for Infective Diseases
city: Zenica
country: Bosnia and Herzegovina
facility: Cantonal Hospital Zenica; Department for Infective Diseases
city: Sofia
country: Bulgaria
facility: MHAT Tokuda Hospital Sofia; Department of Gastroenterology at Clinic of Internal Deseases
city: Varna
country: Bulgaria
facility: Mhat Sveta Marina; Clinic of Gastroenterology
city: Beijing
country: China
facility: Beijing Ditan Hospital
city: Beijing
country: China
facility: Beijing 302 Hospital; No. 2 Infectious Disease Section
city: Beijing
country: China
facility: Peking University People's Hospital
city: Beijing
country: China
facility: Beijing You An Hospital; Digestive Dept
city: Chengdu
country: China
facility: West China Hospital, Sichuan University
city: Chongqing
country: China
facility: The Second Affiliated Hospital, Chongqing Medical University
city: Guangzhou
country: China
facility: The Eighth People's Hospital of Guangzhou
city: Guangzhou
country: China
facility: Guangdong General Hospital
city: Hangzhou
country: China
facility: Hangzhou Sixth People's Hospital
city: Harbin
country: China
facility: The 1st Affiliated Hospital of Harbin Medical University
city: Jinan
country: China
facility: Jinan Infectious Diseases Hospital
city: Nanjing
country: China
facility: Nanjing No.2 Hospital; Liver Disease Department
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
city: Shanghai
country: China
facility: Huashan Hospital Affiliated to Fudan University
city: Shanghai
country: China
facility: The 85th Hospital of P.L.A.
city: Shanghai
country: China
facility: Shanghai Public Health Clinical Center
city: Shen Zhen
country: China
facility: Shenzhen Donghu Hospital
city: ShenYang
country: China
facility: Shengjing Hospital of China Medical University
city: Shi Jiazhuang
country: China
facility: The Third Hospital of Hebei Medical University
city: Shijiazhuang
country: China
facility: Bethune International Peace Hospital of PLA
city: Urumqi
country: China
facility: Xinjiang Uygur Autonomous Region Hospital of Chinese Traditional Medicine
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical College
city: Xi'an
country: China
facility: The Second Affiliated Hospital of The Fourth Military Medical University (Tangdu Hospital)
city: Cairo
country: Egypt
facility: Dr. Ibrahim Mostafa Clinic
city: Cairo
country: Egypt
facility: Yehia Elshazly Clinic for Hepatology and Gastroentrology
city: Cairo
country: Egypt
facility: Dr.Mohamed Amr Affifi Clinic
city: Cairo
country: Egypt
facility: Dr.Nabil Fawzy private clinic
city: Cairo
country: Egypt
facility: Dr.Nadia Elansary Clinic
city: Giza
country: Egypt
facility: Dr. Taher Elzanaty clinic
city: Giza
country: Egypt
facility: Dr. Ahmed Monis Clinic
city: Mansoura
country: Egypt
facility: Gamal Sheha Clinic
city: Aix En Provence
country: France
facility: Ch Du Pays D Aix; Gastro Enterologie
city: Amiens
country: France
facility: Hopital Nord; Medecine A
city: Amiens
country: France
facility: Hopital Nord; Reseau Hepatologie Picardie
city: Angers
country: France
facility: Hotel Dieu; Medecine A
city: Argenteuil
country: France
facility: Ch Victor Dupouy; Hepato Gastro Medecine Interne
city: Argenteuil
country: France
facility: Ch Victor Dupouy; Oncologie
city: Avignon
country: France
facility: Ch Henri Duffaut;Gastro Enterologie
city: Besancon
country: France
facility: Hopital Jean Minjoz; Hepatologie
city: Bobigny
country: France
facility: Hopital Avicenne; Unite D Hepatologie
city: Bondy
country: France
facility: Hopital Jean Verdier; Gastro Enterologie
city: Bordeaux
country: France
facility: Hopital Saint Andre; Hepato-Gastro-Enterologie
city: Bourgoin Jallieu
country: France
facility: Ch Pierre Oudot; Gastro Enterologie
city: Caen
country: France
facility: Hopital Cote De Nacre; Gastro Enterologie
city: Chambray Les Tours
country: France
facility: Hopital Trousseau; Gastro Enterologie A Et B
city: Clamart
country: France
facility: Hopital Antoine Beclere; Hepatologie Gastro Enterologie
city: Clermont Ferrand
country: France
facility: Chu Estaing; Medecine Digestive
city: Clichy
country: France
facility: Hopital Beaujon; Gastro Enterologie 1
city: Clichy
country: France
facility: Hopital Beaujon;Hepatologie
city: Corbeil Essonnes
country: France
facility: Ch Sud Francilien; Cons Gastro Enterologie
city: Creil
country: France
facility: Ch Laennec; Medecine IV
city: Creteil
country: France
facility: Hopital Henri Mondor; Hepatologie Gastro Enterologie
city: Dijon
country: France
facility: Hopital Du Bocage; Gastro Enterologie
city: Evry
country: France
facility: Ch Sud Francilien; Gastro Enterologie
city: Grasse
country: France
facility: CABINET
city: La Tronche
country: France
facility: Hopital Albert Michallon; Gastro Enterologie
city: Lagny Sur Marne
country: France
facility: Ch De Lagny Sur Marne; Gastro Enterologie
city: Le Kremlin Bicetre
country: France
facility: Ch De Bicetre; Gastro Enterologie
city: Le Mans
country: France
facility: Ch Du Mans; Medecine Ii
city: Lille
country: France
facility: Hopital Claude Huriez;Gastro Enterologie
city: Limoges
country: France
facility: Hopital Dupuytren; Medecine Interne A
city: Lyon
country: France
facility: Clinique De La Sauvegarde; Exploration Gastro Proctologie
city: Lyon
country: France
facility: Hopital Hotel Dieu; Medecine Interne & D'Hepatologie
city: Lyon
country: France
facility: Hopital De La Croix Rousse; Hepatologie Gastro Enterologie
city: Marseille
country: France
facility: Fondation Hopital Saint Joseph; Gastro-Enterologie
city: Marseille
country: France
facility: Hopital De La Conception; Gastro Enterologie Endoscopie 2E Nord
city: Marseille
country: France
facility: Hopital De La Conception; Rhumatologie
city: Metz
country: France
facility: Hopital N D Bon Secours; Medecine B2
city: Montauban
country: France
facility: Ch De Montauban; Medecine Interne
city: Montivilliers
country: France
facility: Hopital Jacques Monod; Gastro-Enterologie
city: Montpellier
country: France
facility: Cabinet Medical
city: Montpellier
country: France
facility: Hopital Saint-Eloi; Hepatologie-Gastro-Enterologie
city: Mulhouse
country: France
facility: Hopital Emile Muller; Gastro Enterologie
city: Nantes
country: France
facility: Hopital Hotel Dieu Et Hme; Hepatologie Gastro Enterologie
city: Nantes
country: France
facility: Cabinet
city: Nimes
country: France
facility: Hopital Caremeau; Gastro Enterologie
city: Niort
country: France
facility: Ch Georges Renon; Maladies Infectieuses
city: Orleans
country: France
facility: Hopital La Source; Medecine H
city: Paris
country: France
facility: Fondation Institut Arthur Vernes; Institut Arthur Vernes
city: Paris
country: France
facility: Hopital Saint Antoine; Hepatologie-Gastr-Enterologie
city: Paris
country: France
facility: CH Pitie Salpetriere; Hepathologie Gastro Enterologie
city: Paris
country: France
facility: Hopital Bichat Claude Bernard; Hepatologie Gastro Enterologie
city: Perpignan
country: France
facility: Hopital Saint Jean; Hematologie
city: Pessac
country: France
facility: Hopital Du Haut-Leveque; Gastro-Enterologie
city: Reims
country: France
facility: Hopital Robert Debre; Gastro Enterologie
city: Rennes
country: France
facility: Hopital de Pontchaillou; Medicine Interne - Hepatologie
city: Rouen
country: France
facility: Hopital Charles Nicolle; Gastro Enterologie
city: Saint Laurent Du Var
country: France
facility: Institut Arnault Tzanck; Medecine I Gastro Enterologie
city: St Maurice
country: France
facility: Hopital Esquirol; Cons Externes
city: Strasbourg
country: France
facility: Hopital Civil; Hepatologie-Gastro-Enterologie
city: Toulon
country: France
facility: Cabinet Medical Gastro Enterologie
city: Toulon
country: France
facility: Hopital Font Pre; Gastro Enterologie
city: Toulouse
country: France
facility: Hopital Purpan;Gastro Enterologie Hepatologie
city: Toulouse
country: France
facility: Clinique Ambroise Pare; Medecine
city: Vandoeuvre-les-nancy
country: France
facility: Hopitaux de Brabois - Gastro-Entereologie
city: Villejuif
country: France
facility: Hopital Paul Brousse; Centre Hepatologie Biliaire
city: Berlin
country: Germany
facility: Charité Universitätsmedizin Berlin; Campus Mitte, Centrum 12, Medizinische Poliklinik
city: Berlin
country: Germany
facility: Praxis Dr. med. Christine John
city: Berlin
country: Germany
facility: überörtl.Gem.Praxis Dres. Stephan Dupke Axel Baumgarten
city: Berlin
country: Germany
facility: Dres.Bernd Möller und Renate Heyne
city: Berlin
country: Germany
facility: Praxis Dr. Heyne
city: Berlin
country: Germany
facility: Charité - Campus Benjamin Franklin; Zentrum fuer Innere Medizin, Med. Klinik I
city: Berlin
country: Germany
facility: Campus Virchow-Klinikum Charité Centrum 13; Medizinische Klinik; Abt.Hepatologie u.Gastroenterologie
city: Berlin
country: Germany
facility: CAMPUS VIRCHOW-KLINIKUM; Charité Centrum 13; Med. Klinik Abt. Hepatologie u. Gastroenterologie
city: Berlin
country: Germany
facility: Dres. Jörg Gölz und Arend Moll
city: Bonn
country: Germany
facility: Universitätsklinikum Bonn Med. Klinik u. Poliklinik I
city: Düsseldorf
country: Germany
facility: Universitätsklinikum Klinik f. Gastroenterologie Hepatologie und Infektiologie
city: Erlangen
country: Germany
facility: Universitätsklinikum Erlangen; Medizinische Klinik 1
city: Essen
country: Germany
facility: Universitaetsklinikum Essen, Innere Klinik und Poliklinik fuer Tumorforschung
city: Frankfurt am Main
country: Germany
facility: Praxis PD Dr.med. Gerlinde Teuber
city: Freiburg
country: Germany
facility: Universitätsklinikum Freiburg Medizinische Klinik Innere Medizin I
city: Giessen
country: Germany
facility: Universitätsklinikum Gießen und Marburg GmbH Standort Gießen Medizinische Klinik II
city: Hamburg
country: Germany
facility: Med. Versorgungszentrum ifi-Institut
city: Hamburg
country: Germany
facility: Infektionsmedizinisches Centrum Hamburg ICH Grindel
city: Hamm
country: Germany
facility: St.Marien-Hospital Klinik Knappenstraße Klinik f.Gastroenterologie
city: Hannover
country: Germany
facility: Medizinische Hochschule Zentrum Innere Medizin Abt.Gastroenterologie, Endokrinologie und Hepatologie
city: Heidelberg
country: Germany
facility: Uni Heidelberg Med. Klinik; Innere Medizin IV
city: Herne
country: Germany
facility: Dres.Dietrich Hüppe Gisela Felten und Heinz Hartmann
city: Jena
country: Germany
facility: Universitätsklinikum Jena; Klinik für Innere Medizin II
city: Kiel
country: Germany
facility: Universitätsklinikum S.-H. Campus Kiel Klinik für Innere Medizin I Gastroenterologie Hepotologie
city: Lübeck
country: Germany
facility: Universitätsklinikum Schleswig-Holstein / Campus Lübeck, Med. Klinik I, Transplantationszentrum
city: Magdeburg
country: Germany
facility: Universitätsklinikum Magdeburg Klinik für Gastroenterologie und Hepatologie
city: Mainz
country: Germany
facility: Uniklinik Mainz; I. Medizinische Klinik
city: München
country: Germany
facility: Klinikum rechts der Isar der TU München; II. Medizinische Klinik & Poliklinik
city: Münster
country: Germany
facility: Dr.med.Heiner W.Busch und Stefan Christensen
city: Münster
country: Germany
facility: Universitätsklinikum Münster Klinik und Poliklinik für Transplantationsmedizin
city: Nürnberg
country: Germany
facility: Klinikum Nord Medizinische Klinik 6
city: Offenburg
country: Germany
facility: St. Josefs Klinik; Medizinische Klinik
city: Salzgitter
country: Germany
facility: Klinikum Salzgitter-Lebenstedt Medizinische Klinik I
city: Stuttgart
country: Germany
facility: Dres. Andreas Schaffert Andreas Trein und Edith Ißler u.w.
city: Ulm
country: Germany
facility: Universitätsklinikum Ulm; Medizinische Uni-Klinik III Abt. Innere Medizin III Hämatologie u. Onkolo.
city: Wuerzburg
country: Germany
facility: Medizinische Universitätsklinik; Med. Klinik Ii, Infektiologie
city: Wuppertal
country: Germany
facility: Praxis Sabine Mauruschat
city: Tuen Mun
country: Hong Kong
facility: Tuen Mun Hospital; Medicine & Geriatrics
city: New Delhi
country: India
facility: Indraprastha Apollo Hospitals
state: Delhi
city: Gurgaon
country: India
facility: Medanta -The Medicity; Department of Digestive and Hepatobiliary Sciences
city: Guwahati
country: India
facility: Institute of Digestive Diseases
city: Mumbai
country: India
facility: Opp Jaslok Hospital
city: Pune
country: India
facility: Krishnai Clinic
city: Pune
country: India
facility: Medipoint Clinic
city: Pune
country: India
facility: Pai Clinic and Diagnostic Center
city: Trivandrum
country: India
facility: Sree Gokulam Medical College and Research Foundation
city: Bandung
country: Indonesia
facility: Boromeus Hospital; Hepatology
city: Bandung
country: Indonesia
facility: Santosa Bandung International Hospital; Hepatology
city: Bandung
country: Indonesia
facility: Hasan Sadikin Hospital; Digestive Surgery
city: Jakarta
country: Indonesia
facility: Klinik Hati; Hepatology
city: Jakarta
country: Indonesia
facility: PGI Cikini Hospital; Hepatology
city: Jakarta
country: Indonesia
facility: Central Army Hospital Rspad Gatot Soebroto; Pulmonology
city: Jakarta
country: Indonesia
facility: Cipto Mangunkusumo General Hospital; Hematology & Oncology
city: Jakarta
country: Indonesia
facility: Medistra Hospital; Hepatology
city: Jakarta
country: Indonesia
facility: Mitra International Jatinegara Hospital; Hepatology
city: Jakarta
country: Indonesia
facility: Klinik Kimia Farma
city: Surabaya
country: Indonesia
facility: Dr. Soetomo Hospital; Kidney and Hipertansion
city: Tangerang
country: Indonesia
facility: Bintaro International Hospital, Hepatology
city: Dublin
country: Ireland
facility: Mater Misericordiae University Hospital;Gastrointestinal Unit/Center for Liver Disease
city: Dublin
country: Ireland
facility: St. James Hospital; Hepatology
city: Amman
country: Jordan
facility: Al-Bashir Hospital
city: Amman
country: Jordan
facility: Prince Hamzeh Hospital; Internal Medicine
city: Irbid
country: Jordan
facility: King Abdullah University Hospital
city: Anyang
country: Korea, Republic of
facility: Pyungchon Sacred Heart Hospital
city: Busan
country: Korea, Republic of
facility: Pusan University Hospital
city: Busan
country: Korea, Republic of
facility: Inje University Pusan Paik Hospital
city: Chooncheon
country: Korea, Republic of
facility: Chooncheon Sacred Heart Hospital
city: Daegu
country: Korea, Republic of
facility: Kyungpook National Uni Hospital; Internal Medicine
city: Daejeon
country: Korea, Republic of
facility: Chungnam University Hospital
city: Incheon
country: Korea, Republic of
facility: Inha University Hospital
city: Jeollabuk-do
country: Korea, Republic of
facility: Chonbuk National Uni Hospital
city: Seoul
country: Korea, Republic of
facility: Eulji General Hospital
city: Seoul
country: Korea, Republic of
facility: ChungAng University Hospital
city: Seoul
country: Korea, Republic of
facility: Yonsei Uni College of Medicine, Severance Hospital; Internal Medicine Dept.
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Centre; Division of Hematology/Oncology
city: Seoul
country: Korea, Republic of
facility: Korea Kuro Hospital; Internal Medicine
city: Seoungnamsi
country: Korea, Republic of
facility: Pundang Jesaeng General Hospital
city: Ulsan
country: Korea, Republic of
facility: Ulsan University Hosiptal
city: Beirut
country: Lebanon
facility: American University of Beirut - Medical Center
city: Beirut
country: Lebanon
facility: Beirut Governmental University Hospital
city: Beirut
country: Lebanon
facility: Hotel-Dieu de France Hospital; Gastroenterology
city: Skopje
country: Macedonia, The Former Yugoslav Republic of
facility: Clinical Center Skopje; Gastroenterohepatology
city: Skopje
country: Macedonia, The Former Yugoslav Republic of
facility: Clinical Center Skopje; Infectious Diseases
city: Casablanca
country: Morocco
facility: Cabinet Privé Pr D Jamil
city: Fes
country: Morocco
facility: CHU Hassan 2; Service Gastro Enterologie Pr IBRAHIMI
city: Rabat
country: Morocco
facility: Centre Hospitalier Universitaire Ibn Sina; Service de Gastro-entérologie Essaid
city: Auckland
country: New Zealand
facility: Auckland Hospital; New Zealand Liver Transplant Unit
city: Hamilton
country: New Zealand
facility: Waikato Hospital; Gastroenterology
city: Whakatane
country: New Zealand
facility: Hepatitis Foundation
city: Faisalabad
country: Pakistan
facility: Allied Hospital; Department of Medicine
city: Islamabad
country: Pakistan
facility: Islamabad Specialist Clinic
city: Karachi
country: Pakistan
facility: Akbar Center
city: Karachi
country: Pakistan
facility: Dow University of Health Sciences; Department of Medicine
city: Karachi
country: Pakistan
facility: Medicare Clinics
city: Lahore
country: Pakistan
facility: Sheikh Zayed Hospital; Department of Gastroentrology
city: Lahore
country: Pakistan
facility: Kanaan Clinic
city: Peshawar
country: Pakistan
facility: Saeed Anwar Medical Centre
city: Rawalpindi
country: Pakistan
facility: Combined Military Hospital; Department of Medicine
city: Rawalpindi
country: Pakistan
facility: Holy Family Hospital; Department of Medicine
city: Bialystok
country: Poland
facility: Medical Uni of Bialystok; Infectious Diseases
city: Bydgoszcz
country: Poland
facility: Hospital For Infectious Diseases; Infectiology
city: Chorzow
country: Poland
facility: Szpital Specjalistyczny; Oddzial Obserwacyjno - Zakayny
city: Gdansk
country: Poland
facility: Pomorskie Centrum Chorob Zakaznych i Gruzlicy
city: Krakow
country: Poland
facility: Krakowski Szpital Specjalistyczny im. Jana Pawla II; Oddzial Wirusowego Zapalenia Watroby
city: Lancut
country: Poland
facility: Centrum Medyczne
city: Lodz
country: Poland
facility: Medical Uni of Lodz; Infectious Diseases
city: Lodz
country: Poland
facility: Wojewódzki specjalistyczny szpital im. Bieganskiego; Oddział Obserwacyjno-Zakazny i Chorob Watroby
city: Warszawa
country: Poland
facility: Inst. of Infectious & Parasitic Diseases; Clinic of Hepatology & Aquired Immunodeficiencies
city: Warszawa
country: Poland
facility: Centralny Szpital Kliniczny MSWiA; Oddzial Chorob Wewnetrznych i Hepatologii
city: Wroclaw
country: Poland
facility: Wojewodzki Szpital; Specjalistyczny Chorob Zakaznych
city: Zielona Góra
country: Poland
facility: NZOZ Lubuska Specjalistyczna Poradnia Chorob Watroby
city: Łodz
country: Poland
facility: Specjalistyczny Szpital Wojewódzki im. Biegańskiego; Klinika Chorób Zakaźnych i Hepatologii UM
city: Lisboa
country: Portugal
facility: Hospital de Santa Maria; Servico de Gastrenterologia e Hepatologia
city: Porto
country: Portugal
facility: Hospital Geral de Santo Antonio; Servico de Gastrenterologia
city: Porto
country: Portugal
facility: Hospital de Sao Joao; Servico de Gastrenterologia
city: Bucharest
country: Romania
facility: Cantacuzino Clinical Hospital;Gastroenterology Department
city: Bucharest
country: Romania
facility: Institutul De Boli Infectioase Matei Bals; Sectia Clinica II Boli Infectioase Adulti
city: Bucharest
country: Romania
facility: The Hospital of Tropical and Infectious Disease Victor Babes
city: Craiova
country: Romania
facility: Clinical Infectious Diseases Hospital Victor Babes
city: Craiova
country: Romania
facility: Spitalul Clinic de Boli Infectioase si Tropicale Dr. Victor; INFECTIOUS DISEASE
city: Alkhobar
country: Saudi Arabia
facility: King Fahad University Hospital; Internal Medicine
city: Riyadh
country: Saudi Arabia
facility: Riyadh Military Hospital
city: Riyadh
country: Saudi Arabia
facility: King Faisal Specialist Hospital & Research Centre; Oncology
city: Riyadh
country: Saudi Arabia
facility: King Fahad Medical City; Gastroentrology
city: Tabuk
country: Saudi Arabia
facility: North West Armed Forces Hospital; Internal Medicine
city: Bangkok
country: Thailand
facility: Siriraj Hospital
city: Chiang Mai
country: Thailand
facility: Chiang Mai Uni Hospital; Faculty of Medicine
city: Songkhla
country: Thailand
facility: Songklanagarind Hospital; Division of Gastroenterology
city: Dubai
country: United Arab Emirates
facility: Rashid Hospital; Gastroenterology
city: Hull
country: United Kingdom
facility: Hull Royal Infirmary; Department Hepatology and Gastroenterology
city: London
country: United Kingdom
facility: The Royal London Hospital
city: London
country: United Kingdom
facility: King'S College Hospital
city: London
country: United Kingdom
facility: St. Georges Uni of London; Gastroenterology & Hepatology
city: London
country: United Kingdom
facility: University College London; Hepatology
city: London
country: United Kingdom
facility: Imperial College Healthcare Trust
city: Manchester
country: United Kingdom
facility: Manchester Royal Infirmary; Department Of Medicine
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References: