louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06158308: Outcome of Laparoscopic Appendicectomy Versus Open Appendicectomy in Sudanese Patients
Official title: Outcome of Laparoscopic Appendicectomy Versus Open Appendicectomy in Sudanese Patients: Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: General Surgery
Lead sponsor: National Center for Gastroentestinal and Liver Disease
Sponsor class: OTHER
First posted: 2023-12-06
Enrollment: 340
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study includes all patients those underwent appendectomy during the study period.

Brief summary: Background: Laparoscopic appendectomy as a minimal invasive procedure had low morbidity and mortality. It affords a direct diagnosis of the problem, allows determination of the appropriate treatment. Open appendectomy is global treatment of acute appendicitis can be done by many incisions, and associated with considerable complications.

Materials and Methods: This is a cross sectional descriptive hospital-based study to study the outcome of laparoscopic appendectomy versus open appendectomy at Elmak Nimer University Hospital over the study period. All patients in the study period who underwent appendectomy was included, data is collected through standard structured data collection sheet and analyzed by using SPSS v24.0.


Eligibility criteria: Inclusion Criteria:

* All patients in the study period who underwent appendectomy were included.

Exclusion Criteria:

* Patientspresented with complicated appendicitis
* Acute appendicitis with comorbiditites
* Pregnant ladies
* Patients of stump appendicitis .
* Patient with inadequate data

Primary outcomes:
measure: The rate of post-operative complications
timeFrame: Jan 2019 - Jan 2021
Secondary outcomes:
Other outcomes:
Locations:
city: Shandi
country: Sudan
facility: Medicine, Elmak Nemir University
state: Alnahr Alabyad
Study officials:
References:
Clinical trial NCT02832908: Evaluation of the Physiopathological Phenomena and the Haemodynamic and Cerebral Metabolic Effects From Semi-seated Position to Lying Position in Patients With Brain Trauma
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Traumatic Brain Injury
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2016-07-14
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP

Brief summary: Brain trauma is an important burden in traumatologic intensive care. In these patients the treatment is guided by a cluster of multimodal monitoring parameters. Despite this it is difficult to assess the actual physiopathologic status of the brain. Changing the position of these patients (semi-seated to lying position) causes changes in the hémodynamics brain conditions, so in monitoring parameters . The analysis of these changes can givr us valuable clinically informations.

Detailed description: Severe brain trauma (CGS \< 8 ) are included. PIC, PA, PVC, EKG, airway pressure, SjO2 and NIRSS are continuously monitored.

The patients are in semi seated (30°) position. Once a day they are in supine (0°) for 30 minutes. We record every parameters before and at the end of this supine period.

After time domain and frequency domain signal processing, this parameters are compared to deduct clinical relevant conclusions.

Eligibility criteria: Inclusion Criteria:

* patients with a severe head trauma estimated by the Glasgow Coma Scale and by the Glasgow Outcome Scale
* age \> 18

Exclusion Criteria:

* Other neurological pathology

Primary outcomes:
measure: ASSESSMENT OF THE CEREBRAL OXYGENATION
timeFrame: UP TO 6 MONTHS
Secondary outcomes:
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Hôpital Lapeyronie - Département Anesthésie Réanimation A
Study officials:
References:
citation: Dagod G, Roustan JP, Bringuier-Branchereau S, Ridolfo J, Martinez O, Capdevila X, Charbit J. Effect of a temporary lying position on cerebral hemodynamic and cerebral oxygenation parameters in patients with severe brain trauma. Acta Neurochir (Wien). 2021 Sep;163(9):2595-2602. doi: 10.1007/s00701-021-04851-x. Epub 2021 Jul 8.
Clinical trial NCT03732508: SHR-1316 in Combination With Chemotherapy in Patients With Esophageal Squamous Cell Cancer
Official title: SHR-1316, a Novel Anti-PD-L1 Antibody, in Combination With Irinotecan Liposome and Fluorouracil in Patients With Esophageal Squamous Cell Cancer: a Phase II Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Advanced Esophageal Squamous Cell Cancer
Lead sponsor: Jiangsu HengRui Medicine Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2018-11-06
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the progression-free survival (PFS) of Chemotherapy combined with SHR-1316 in patients with advanced esophageal squamous cell cancer.


Eligibility criteria: Inclusion Criteria:

1. Histologically or cytologically confirmed unresectable local advanced/recurrent or metastasis esophageal squamous cell carcinoma;
2. No previous systemic anti-tumor treatment;
3. Subjects must have at least one measurable tumor lesion per RECIST 1.1;
4. ECOG: 0-1;
5. Adequate organ and bone marrow function;

Exclusion Criteria:

1. Allergic to monoclonal antibodies, any SHR-1316 components,Irinotecan , Fluorouracil ;
2. Prior therapy as follow:

   1. Anti-PD-1 or anti-PD-L1;
   2. Any experimental drugs within 4 weeks of the first dose of study medication;
   3. Received major operations or serious injuries within 4 weeks of the first dose of study medication;
   4. Received last dose of anticancer therapy (including chemotherapy, radiotherapy, targeted therapy, etc.) within 4 weeks of the first dose of study medication;
3. Not recovered to ≤CTCAE 1 from adverse events (except for hair loss) due to a previously anti-tumor treatment;
4. Subjects with any active autoimmune disease or history of autoimmune disease;
5. Pregnancy or breast feeding;

Primary outcomes:
measure: Duration of Progression-Free Survival (PFS)
timeFrame: approximately 22 months
Secondary outcomes:
measure: Disease Control Rate(DCR)
timeFrame: approximately 22 months
measure: Objective Response Rate(ORR)
timeFrame: approximately 22 months
measure: Overall Survival(OS)
timeFrame: approximately 22 months
measure: Adverse Events(AE)
timeFrame: approximately 22 months
Other outcomes:
Locations:
city: Beijing
country: China
facility: Cancer Institute and Hospital,Chinese Academy of Medical Science
state: Beijing
Study officials:
affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
name: Jing Huang
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01804608: Kinematics of Lower Limb, Pain and Function of the Women With Patellofemoral Pain Syndrome
Official title: Kinematics of Lower Limb, Pain and Function of the Women With Patellofemoral Pain Syndrome Who Underwent Two Types Treatment: Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Patellofemoral Pain Syndrome
Lead sponsor: University of Nove de Julho
Sponsor class: OTHER
First posted: 2013-03-05
Enrollment: 34
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Assess pain, function, trunk and lower limbs kinematic during functional tasks after hip muscle strengthening versus hip muscle strengthening and sensory motor training in lower limbs.


Eligibility criteria: Inclusion Criteria:

* Sedentary women,
* previous knee pain last 3 months in at least two of the following activities: sitting for long periods, walk up or down stairs, squat, running and jumping

Exclusion Criteria:

* Lower limb surgery,
* patella displacement
* knee instability
* Heart or locomotor disorders which might influence the evaluation

Primary outcomes:
measure: Function and pain intensity
timeFrame: 4 weeks
Secondary outcomes:
measure: Muscle strength of the hip and knee muscles
timeFrame: 4 weeks
measure: Three-dimensional kinematics of the trunk and lower limbs during the step down task
timeFrame: 4 weeks
measure: Function and pain intensity
timeFrame: 3 and 6 months after randomization
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Universidade Nove de Julho
Study officials:
References:
citation: Rabelo ND, Lima B, Reis AC, Bley AS, Yi LC, Fukuda TY, Costa LO, Lucareli PR. Neuromuscular training and muscle strengthening in patients with patellofemoral pain syndrome: a protocol of randomized controlled trial. BMC Musculoskelet Disord. 2014 May 16;15:157. doi: 10.1186/1471-2474-15-157.
Clinical trial NCT04785508: Effects Neuromuscular Taping Technique on Upper Limbs Edema in Cardiac Surgery Patients
Official title: Effects Neuromuscular Taping Technique on Upper Limbs Edema in Cardiac Surgery Patients
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Edema Limbs
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2021-03-08
Enrollment: 10
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to verify the efficacy of the decompression technique of neuromuscular taping on cardiac surgery patients in whom edema of the upper limbs occurs due to post-operative water overload.


Eligibility criteria: Inclusion Criteria:

* Cardiac surgery patients with postoperative edema of the upper limbs due to water overload

Exclusion Criteria:

* absence of edema,
* previous mastectomy and lymphadenectomy,
* surgery or fractures or infection of the upper limb,
* previous or current deep vein thrombosis.

Primary outcomes:
measure: circumference's change of index finger, metacarpus, wrist, mid forearm, elbow and upper arm
timeFrame: measure in millimeter on first postoperative day: before application of tape; and then, every day for the first 3 days, after tape removing, and before the new application.
Secondary outcomes:
measure: measurement of the intensity of pain
timeFrame: Measure every day for the 3 days of treatment, before application of tape
measure: movement ability of wrist, hand and arm
timeFrame: measure every day for the 3 days of treatment, before application of tape
measure: muscle strength measure
timeFrame: measure every day for the 3 days of treatment, before application of tape
Other outcomes:
Locations:
city: Roma
country: Italy
facility: Maria Enrica Antoniucci
Study officials:
affiliation: FPG IRCCS
name: Maria Enrica Antoniucci, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06521008: Effect of Diaphragmatic Training on Urgency Urinary Incontinence in Postmenopausal Women
Official title: Effect of Diaphragmatic Training on Urgency Urinary Incontinence in Postmenopausal Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Urge Incontinence
Urinary Incontinence
Postmenopausal Disorder
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-07-25
Enrollment: 60
Sex: FEMALE
Minimum age (years): 55
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: single blinded randomized controlled trial
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to determine the effect of diaphragmatic training on urgency urinary incontinence in postmenopausal women.

Detailed description: Urgency urinary incontinence affects 9-13% of women, increasing with age and impacting daily activities, quality of life, depression, and social isolation. It is a significant source of dependency among the elderly and a factor in nursing home admissions. Untreated incontinence can lead to falls, infections, and loss of independence. Conservative management is the first-line therapy, but pelvic floor muscle training is a potential treatment method. This study aims to evaluate the effectiveness of diaphragmatic training on urinary incontinence in postmenopausal women.

Eligibility criteria: Inclusion Criteria:

* Postmenopausal women suffer from UUI.
* They will be multipara more than 1.
* Their age will range from 55-65 years old.
* Their body mass index (BMI) will range from 25-29.9 kg/m2..
* They will experience menopause at least for 3 years.

Exclusion Criteria:

* Urinary tract infection
* Previous surgery for urinary incontinence
* Upper motor neuron diseases
* History of genito-urinary cancer
* Previous pelvic irradiation
* Pure stress urinary incontinence
* Genital prolapse
* Diabetes mellitus
* Pace maker

Primary outcomes:
measure: assessing the change in Urodynamics (first desire to void)
timeFrame: up to 12 weeks
measure: assessing the change in Urodynamics (first sensation of bladder filling)
timeFrame: up to 12 weeks
measure: assessing the change in Urodynamics (maximum bladder capacity)
timeFrame: up to 12 weeks
Secondary outcomes:
measure: assessing the change in weight and height
timeFrame: up to 12 weeks
measure: assessing the change in bladder ascending movement
timeFrame: up to 12 weeks
measure: assessing the change in Urinary function
timeFrame: up to 12 weeks
measure: assessing the change in body mass index
timeFrame: up to 12 weeks
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: OM El Masreen General Hospital
Study officials:
References:
Clinical trial NCT01257308: Research of the EML4-ALK Gene Expression in the Pleural Effusion or Tumor Tissue From Lung Cancer Patients
Official title: Research of the EML4-ALK Gene Expression in the Pleural Effusion or Tumor Tissue From Lung Cancer Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Lung Cancer Patients
Keywords: lung cancer
Lead sponsor: Taipei Medical University WanFang Hospital
Sponsor class: OTHER
First posted: 2010-12-09
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Lung Cancer Patients

Brief summary: We wants to analyse the EML4-ALK mutation rate in the patients who have non-small cell lung cancer.


Eligibility criteria: Inclusion Criteria:

* 20 or more than 20 years of age
* The pathological diagnosis confirmed lung cancer
* Patients have achieved pleural effusion, or surgical biopsy to obtain tumor tissue specimens
* The patient had signed inform consent

Exclusion Criteria:

* pleural effusion or tumor tissue can not be obtained
* the patient is not suitable to join the research according to the judgement by the investigator

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University - WanFang Hospital
Study officials:
affiliation: Taipei Medical University WanFang Hospital
name: Hsin-Gjin Eugene Liu
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02182908: FDG PET-Scan Analysis of Evolutivity of Non-surgical Aneurysm of Abdominal Aorta
Official title: ANALYSE EN MORPHO-TEP AU FDG DE L'EVOLUTIVITE DES ANEVRISMES ABDOMINAUX AORTIQUES NON CHIRURGICAUX UNE ETUDE MULTICENTRIQUE DE L'INTER-REGION NORD-EST
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Medically-treated Aneurysm of Abdominal Aorta
Keywords: Aneurysm of abdominal aorta
18F-fluorodesoxyglucose (FDG-F18)
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2014-07-08
Enrollment: 51
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: The primary aim of the study is to determine if the evolutivity of global and segmentary captation of FDG-F18, which can be measured in the wall of abdominal aorta aneurysm, is predictive of the 9 month evolution of diameter and volume of the aneurysm, measured globally and segmentary in angioscan.


Eligibility criteria: Inclusion Criteria:

* AAA with a minimum diameter of 40 mm, calculated with a standardized method
* No indication for an immediate surgery or endoprothesis implantation
* Age above 18 (except for patient under supervision)
* Patient having read the information letter and signed the informed consent

Exclusion Criteria:

- AAA should have no other specific cause than atherosclerosis

Primary outcomes:
measure: Association between overall baseline 18-FDG uptake intensity of the aneurysm and its 9-month maximal diameter and/or volume in patients with diameter change greater than 4 mm/year
timeFrame: 9 months
Secondary outcomes:
measure: Association between initial 18-FDG uptake of individual aneurysmal segments and their 9-month diameter change.
timeFrame: 9 months
measure: Contribution of overall 18-FDG uptake to the predictive values of other baseline characteristics of the aneurysm (diameter, volume, thickness and wall stress, clinical and biological values)
timeFrame: 9 months
measure: Association between overall 18-FDG uptake and other baseline characteristics of the aneurysm (diameter, volume, thickness and wall stress, clinical and biological values).
timeFrame: 9 months
measure: Association between 9-month overall 18-FDG uptake change and variation of plasmatic biomarkers of inflammation, proteolysis and coagulation.
timeFrame: 9 months
Other outcomes:
Locations:
city: Besançon
country: France
facility: Service de Médecine Nucléaire - CHU JEAN Minjoz
city: Vandoeuvre-Lès-Nancy
country: France
facility: CHU de Nancy - Hôpital Brabois
Study officials:
References:
Clinical trial NCT02333708: Study of Circulating Microparticles in Giant Cell Arteritis
Official title: Study of Circulating Microparticles in Giant Cell Arteritis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Giant Cell Arteritis
Acute Phase
Lead sponsor: University Hospital, Caen
Sponsor class: OTHER
First posted: 2015-01-07
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: primary and secondary care hospital

Brief summary: To demonstrate that microparticles (MPs), having a powerful procoagulant potential, are in larger amounts in the blood of patients with histologically proven giant cell arteritis (GCA), compared with patients matched for age, sex and with or without inflammatory syndrome.


Eligibility criteria: For GCA group:

Inclusion Criteria:

* Men and women ≥ 18 years of age Patient affiliated to social security regimen
* Informed and having signed the consent form to take part in the study.
* Diagnosis of GCA, meeting at least 3 of the following 5 American College of Rheumatology (ACR) criteria for the diagnosis of GCA, including inflammatory syndrome and having

  * Either temporal artery biopsy showing characteristic GCA abnormality
  * Or inflammatory arteritis on imaging examination

Exclusion Criteria:

* Persons under protection of the court or guardianship
* Inability to understand or to follow study procedures
* Dementia
* cancer diagnosed within the previous 5 years (except for non-melanoma skin cancer or in situ carcinoma of the cervix)non-contributory or inconclusive temporal artery biopsy
* Any conditions that might interfere with MPs level: diabetes, recent endo-arterial gesture, current treatment with corticosteroids.
* Participation in another ongoing clinical trial Current anticoagulant therapy
* Active infectious disease

Primary outcomes:
measure: Level of microparticles in the blood of patients with histologically proven giant cell arteritis.
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Caen
country: France
facility: Centre Hospitalier Universitaire Côte de Nacre
Study officials:
References:
Clinical trial NCT05241808: Girls Can...Move! Testing the Feasibility of a Community-based Physical Activity Intervention for Adolescent Girls
Official title: Girls Can...Move! Testing the Feasibility of a Community-based Physical Activity Intervention for Adolescent Girls
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physical Inactivity
Keywords: physical literacy
female
accelerometer
exercise
Lead sponsor: University of Kentucky
Sponsor class: OTHER
First posted: 2022-02-16
Enrollment: 17
Sex: FEMALE
Minimum age (years): 11
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this research is to learn about how to promote physical activity among adolescent girls by testing the feasibility and initial effectiveness of the Girls Can...Move! intervention. Girls Can...Move! will target each component of physical literacy by providing opportunities for adolescent girls to gain knowledge about their own physical activity level, to explore and practice different types of physical activities, and to learn from active female role models. Female participants (n = 30) from one middle school will be randomly assigned to the Girls Can...Move! intervention group or a control group at a 1:1 ratio. The primary outcome variables, physical activity and physical literacy, will be assessed before and after the 8-week Girls Can...Move! intervention using accelerometers and online surveys.


Eligibility criteria: Inclusion Criteria:

* Female
* Enrolled in 6th, 7th, or 8th grade at target school

Exclusion Criteria:

* Engage in 60 minutes of moderate-to-vigorous physical activity on more than 3 days per week
* Doctor has told child/parent that there are certain types of activities that the child should not do
* Preexisting injuries or health conditions that limit physical activity

Primary outcomes:
measure: Feasibility of the Girls Can...Move! intervention
timeFrame: pre-intervention (week 0)
measure: Change in physical activity
timeFrame: pre-intervention immediately following 8-week intervention period (week 9)
measure: Change in physical literacy
timeFrame: pre-intervention (week 0) and immediately following 8-week intervention period (week 9)
Secondary outcomes:
measure: Change in peer social support
timeFrame: pre-intervention (week 0) and immediately following 8-week intervention period (week 9)
measure: Change in parental social support
timeFrame: pre-intervention (week 0) and immediately following 8-week intervention period (week 9)
Other outcomes:
Locations:
city: Lexington
country: United States
facility: University of Kentucky
state: Kentucky
Study officials:
References: