Clinical trial NCT00557921: Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
Official title: A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Acute Coronary Syndrome
Myocardial Infarction
Coronary Artery Disease
Percutaneous Coronary Intervention
Keywords: ACS
CAD
MI
PCI
PTCA
NSTEMI
STEMI
acute coronary syndrome
cerebrovascular disorders
coronary artery stent placement
coronary thrombosis
myocardial infarction
myocardial ischemia
percutaneous coronary intervention
percutaneous transluminal coronary angioplasty
peripheral vascular diseases
duodenal obstruction
duodenal ulcer
dyspepsia
esophagitis, peptic
gastric outlet obstruction
gastroduodenal ulcer
gastroesophageal reflux disease
gastrointestinal hemorrhage
peptic ulcer
peptic ulcer perforation
Lead sponsor: Cogentus Pharmaceuticals
Sponsor class: INDUSTRY
First posted: 2007-11-14
Enrollment: 5000
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer disease, in the setting of concomitant aspirin therapy.

Antiplatelet therapy is an essential element of care for patients with atherothrombotic disease. Bleeding is a fundamental adverse effect of all antiplatelet drugs including aspirin, clopidogrel and dual antiplatelet regimens.

The gastrointestinal tract is the most common site of bleeding related to antiplatelet therapy, typically in connection with peptic ulcer disease. Recently published studies suggest the use of clopidogrel carries a gastrointestinal bleeding risk similar to that of aspirin or non-aspirin non-steroidal anti-inflammatory drugs. Patients taking any two of these drugs (clopidogrel, aspirin and/or non-aspirin NSAIDs) are exposed to an even higher risk of bleeding and ulcer disease.

Cogentus Pharmaceuticals is launching phase 3 trials of a novel combination product, CGT-2168, which has the potential to significantly reduce this problem and increase patient safety. CGT-2168 combines a standard dosage of clopidogrel and a gastroprotectant (omeprazole) in a once-daily pill that may reduce the likelihood of adverse gastrointestinal events.


Eligibility criteria: Inclusion Criteria:

* Patients in whom a requirement for clopidogrel therapy with concomitant aspirin is anticipated for at least the next 12 months. Specific conditions that may confer a need for long-term clopidogrel + aspirin therapy may include non-ST segment elevation acute coronary syndrome (unstable angina/non-Q-wave MI), ST segment elevation acute MI), or new placement of a coronary artery stent.
* For women of childbearing potential, negative pregnancy test prior to randomization and agreement to use effective method of birth control during the study.
* Able to provide written informed consent based on competent mental status.

Exclusion Criteria:

* Patients currently hospitalized for whom discharge is not anticipated within 48 hours of randomization.
* Requirement for current or chronic use of a proton pump inhibitor, H2 receptor blocker, sucralfate or misoprostol.
* Erosive esophagitis, esophageal or gastric variceal disease, or non-endoscopic gastric surgery. Patients with a history of GERD/erosive esophagitis or dyspepsia who do not currently require proton pump blockers will be eligible.
* Receipt of \> 21 days of clopidogrel or another thienopyridine prior to randomization.
* Oral anticoagulation that cannot be safely discontinued for duration of study.
* Recent fibrinolytic therapy.
* Scheduled percutaneous coronary intervention (PCI). Patients may be enrolled upon completion of PCI.
* Recent (\< 30 days prior to randomization) or scheduled coronary artery bypass graft (CABG) surgery.
* Cardiogenic shock at time of randomization, refractory ventricular arrhythmias, or congestive heart failure (NY Heart Association class IV).
* Active pathological bleeding or a history of hereditary or acquired hemostatic disorder.
* History of hemorrhagic stroke, intracranial neoplasm, arteriovenous malformation or aneurysm.
* Systemic corticosteroids except low-dose oral corticosteroids equivalent to prednisone \< or equal to 5 mg/day.
* Allergy or contraindication to clopidogrel or other thienopyridine drugs, omeprazole or other proton pump inhibitor drugs, aspirin or salicylate derivatives, or other study drug ingredients.
* Treatment within 30 days prior to randomization with any investigational drug or device including investigational coronary artery stents or currently enrolled in another interventional drug or device study.
* Women who are pregnant or breastfeeding.
* Life expectancy less than 12 months.
* Laboratory abnormality at screening that is clinically significant or outside protocol-allowed limits, or any other condition that precludes participation in the study in the opinion of the Investigator.

Primary outcomes:
measure: Composite of upper gastrointestinal clinical events, including gastroduodenal bleeding, symptomatic gastroduodenal ulcer, persistent pain with multiple gastric erosions, obstruction or perforation
timeFrame: Anticipated minimum of 48 weeks, up to end of study
Secondary outcomes:
measure: Composite of gastroduodenal bleeding, symptomatic gastroduodenal ulcer, obstruction or perforation
timeFrame: Anticipated minimum of 48 weeks, up to end of study
measure: Composite of gastroduodenal bleeding, obstruction or perforation
timeFrame: Anticipated minimum of 48 weeks, up to end of study
measure: Discontinuation of study medication attributed to gastrointestinal signs or symptoms
timeFrame: Anticipated minimum of 48 weeks, up to end of study
measure: Gastroesophageal reflux disease, as evidenced by symptomatic endoscopically-confirmed erosive esophagitis
timeFrame: Anticipated minimum of 48 weeks, up to end of study
measure: Dyspepsia, defined as an increase of at least ten points on the "pain intensity" component of the SODA instrument from baseline
timeFrame: Anticipated minimum of 48 weeks, up to end of study
measure: Occurrence of a cardiovascular event (cardiovascular death, nonfatal myocardial infarction, CABG or PCI, or confirmed ischemic stroke
timeFrame: Anticipated minimum of 48 weeks, up to end of study
Other outcomes:
Locations:
city: Alexander City
country: United States
facility: Alabama Clinical Research Institute, Inc. (ACRI)
state: Alabama
city: Birmingham
country: United States
facility: Alabama Clinical Therapeutics, LLC
state: Alabama
city: Birmingham
country: United States
facility: Cardio-Thoracic Surgeons P.C.
state: Alabama
city: Birmingham
country: United States
facility: Birmingham Heart Clinic, PC
state: Alabama
city: Geneva
country: United States
facility: John F Simmons , MD PC
state: Alabama
city: Hoover
country: United States
facility: Clinical Research Consultants, Inc.
state: Alabama
city: Huntsville
country: United States
facility: The Heart Center, PC
state: Alabama
city: Mobile
country: United States
facility: Mobile Heart Specialists, PC
state: Alabama
city: Mesa
country: United States
facility: Advanced Cardiac Specialists
state: Arizona
city: Phoenix
country: United States
facility: Redpoint Research
state: Arizona
city: Phoenix
country: United States
facility: Cardiovascular Consultants, Ltd.
state: Arizona
city: Sierra Vista
country: United States
facility: Cochise Clinical Research
state: Arizona
city: Tucson
country: United States
facility: Paradigm Clinical Research, Inc.
state: Arizona
city: Hot Springs
country: United States
facility: Tri-Lakes Research
state: Arkansas
city: Hot Springs
country: United States
facility: Michael A. Frais, Cardiologist, P.A.
state: Arkansas
city: Jonesboro
country: United States
facility: NEA-Clinic Cardiology
state: Arkansas
city: Searcy
country: United States
facility: Searcy Medical Center
state: Arkansas
city: Anaheim
country: United States
facility: Cardiology Consultants of Orange County
state: California
city: Anaheim
country: United States
facility: Chest and Critical Care Consultants, A Medical Group
state: California
city: Buena park
country: United States
facility: Clinical Solutions Advantage
state: California
city: Castro Valley
country: United States
facility: Turns Institute for Clinical Research
state: California
city: Escondido
country: United States
facility: Escondido Cardiology Associates
state: California
city: Laguna Hills
country: United States
facility: Accurate Clinical Trials, Inc.
state: California
city: Laguna Hills
country: United States
facility: Therapeutic Research Institute of Orange County
state: California
city: Lakewood
country: United States
facility: Kirtik Thaker MD
state: California
city: Los Angeles
country: United States
facility: Los Angeles Cardiology Associates
state: California
city: Merced
country: United States
facility: Merced Heart Associates
state: California
city: Mission Viejo
country: United States
facility: Mission Internal Medical Group
state: California
city: Mountain View
country: United States
facility: Altos Cardiovascular Associates
state: California
city: Oceanside
country: United States
facility: Kenneth W. Carr, MD, Cardiology
state: California
city: Rancho Cucamonga
country: United States
facility: Rancho CucamongaClinical Trials
state: California
city: San Bernardino
country: United States
facility: Inland Heart and Vascular Medical Associates
state: California
city: San Diego
country: United States
facility: Ritchken and First
state: California
city: San Francisco
country: United States
facility: Rider Research Group
state: California
city: San Francisco
country: United States
facility: Richard Levy, MD.
state: California
city: San Jose
country: United States
facility: Kaiser Permanente
state: California
city: Santa Ana
country: United States
facility: Medical Helping Hands Research
state: California
city: Santa Monica
country: United States
facility: Pacific Heart Institute
state: California
city: Santa Rosa
country: United States
facility: Radiant Research
state: California
city: Torrance
country: United States
facility: Harbor- UCLA Medical Center
state: California
city: Ventura
country: United States
facility: Ventura Cardiology Consultants Medical Group, Inc.
state: California
city: Colorado Springs
country: United States
facility: Colorado Springs Health Partners
state: Colorado
city: Bridgeport
country: United States
facility: Connecticut Clinical Research
state: Connecticut
city: Hartford
country: United States
facility: Hartford Hospital
state: Connecticut
city: Newark
country: United States
facility: Alfieri Cardiology, PA
state: Delaware
city: Washington
country: United States
facility: Washington V.A. Medical Center
state: District of Columbia
city: Coral Gables
country: United States
facility: Oscar R. Guerra, MD PA
state: Florida
city: Deerfield Beach
country: United States
facility: Deerfield Beach Cardiology Associates
state: Florida
city: Hallandale
country: United States
facility: Dr Jules Cohen
state: Florida
city: Hialeah
country: United States
facility: Empire International Research
state: Florida
city: Hollywood
country: United States
facility: Cardiovascular Consultants of South Florida
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Heart Center
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Center for Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Heart Center
state: Florida
city: Jupiter
country: United States
facility: CVMS Resesarch Institute, LLC
state: Florida
city: Lakeland
country: United States
facility: Watson Clinic Center for Research
state: Florida
city: Melbourne
country: United States
facility: Alpha Medical Research, LLC
state: Florida
city: Miami
country: United States
facility: Empire International Research
state: Florida
city: Miami
country: United States
facility: Suncoast Research Group, LLC
state: Florida
city: Miami
country: United States
facility: Cardiovascular Research Center of South Florida
state: Florida
city: Miami
country: United States
facility: Research Center Phase I-IV of Florida Corp.
state: Florida
city: Miami
country: United States
facility: Empire International Research
state: Florida
city: New Smyrna Beach
country: United States
facility: Bert Fish Medical Center
state: Florida
city: Orlando
country: United States
facility: Central Florida Cardiology Group
state: Florida
city: Orlando
country: United States
facility: Cardiology Assocaites of Orlando d/b/a Orlando Heart Center
state: Florida
city: Palm Harbor
country: United States
facility: Sunset Point Medical Associates
state: Florida
city: Plantation
country: United States
facility: Berma Research Group
state: Florida
city: Port Charlotte
country: United States
facility: Charlotte Heart Group Research Center
state: Florida
city: St. Petersburg
country: United States
facility: Suncoast Cardiovascular Research
state: Florida
city: St. Petersburg
country: United States
facility: The Heart and Vascular Institute of Florida
state: Florida
city: Vero Beach
country: United States
facility: G&G Research Baker-Tombul Cardiology
state: Florida
city: Weston
country: United States
facility: Carlos Levy, D.O.
state: Florida
city: Atlanta
country: United States
facility: Piedmont Hospital
state: Georgia
city: Atlanta
country: United States
facility: Primary Care Specialists, LLC/ ECAST CT
state: Georgia
city: Atlanta
country: United States
facility: Executive Health and Research Associates, Inc.
state: Georgia
city: Columbus
country: United States
facility: Southeast Regional Research Group
state: Georgia
city: Covington
country: United States
facility: Georgia Heart Specialists, LLC
state: Georgia
city: Decatur
country: United States
facility: Ialum Clinical Research Center, LLC
state: Georgia
city: Decatur
country: United States
facility: Ialum Clinical Research Center
state: Georgia
city: Decatur
country: United States
facility: Ialum Clinical Research Center
state: Georgia
city: Savannah
country: United States
facility: Southeast Regional Research Group
state: Georgia
city: Stockbridge
country: United States
facility: Medsouth Primary CareStockbridge
state: Georgia
city: Flossmoor
country: United States
facility: South Suburban Health Professional Group, PC
state: Illinois
city: Melrose Park
country: United States
facility: Consultants in Cardiovascular Medicine
state: Illinois
city: Peoria
country: United States
facility: Methodist Medical Center of Illinois
state: Illinois
city: Anderson
country: United States
facility: Community Clinical Research Center
state: Indiana
city: Avon
country: United States
facility: American Health Network
state: Indiana
city: Elkhart
country: United States
facility: Indiana Medical Research
state: Indiana
city: Evansville
country: United States
facility: Welborn Clinic
state: Indiana
city: Indianapolis
country: United States
facility: Indiana Heart Physicians
state: Indiana
city: Davenport
country: United States
facility: Midwest Cardiovascular Research Foundation
state: Iowa
city: Waterloo
country: United States
facility: Northeast Iowa Medical Education Foundation
state: Iowa
city: Hutchinson
country: United States
facility: Hutchinson Clinic, P.A.
state: Kansas
city: Mission
country: United States
facility: Venture Resource Group, Inc.
state: Kansas
city: Overland Park
country: United States
facility: Midwest Cardiology Assocaites
state: Kansas
city: Ashland
country: United States
facility: Cumberland Cardiology
state: Kentucky
city: Madisonville
country: United States
facility: Trover Health System
state: Kentucky
city: Owensboro
country: United States
facility: Owensboro Heart and Vascular
state: Kentucky
city: Baton Rouge
country: United States
facility: Dolby Research, LLC
state: Louisiana
city: Houma
country: United States
facility: Cardiovascular Institute of the South
state: Louisiana
city: Marrero
country: United States
facility: Heart Clinic of Louisiana Clinical Research, LLC.
state: Louisiana
city: Auburn
country: United States
facility: Maine Research Associates
state: Maine
city: Scarborough
country: United States
facility: Cardiovascular Consultants of Maine, PA
state: Maine
city: South Portland
country: United States
facility: Maine Cardiology Associates
state: Maine
city: Baltimore
country: United States
facility: Good Samaritan Hospital (Medstar Health)
state: Maryland
city: Greenbelt
country: United States
facility: eCast Corporation
state: Maryland
city: Salisbury
country: United States
facility: Atlantic Cardiology Associates, P.A
state: Maryland
city: Salisbury
country: United States
facility: Peninsula Cardiology Associates
state: Maryland
city: Haverhill
country: United States
facility: Pentucket Medical Associates
state: Massachusetts
city: Natick
country: United States
facility: Charles River Medical Associates
state: Massachusetts
city: Bay City
country: United States
facility: Michigan Cardiovascular Institute
state: Michigan
city: Flint
country: United States
facility: Apex Medical Research, AMR, Inc.
state: Michigan
city: Kalamazoo
country: United States
facility: Borgess Research Institute
state: Michigan
city: Midland
country: United States
facility: Michigan Cardiovascular Institute
state: Michigan
city: Saginaw
country: United States
facility: Michigan Cardiovascular Institute
state: Michigan
city: Saginaw
country: United States
facility: Covenant Medical Center, Inc.
state: Michigan
city: St. Clair Shores
country: United States
facility: Academic Heart and Vascular PLLC
state: Michigan
city: Troy
country: United States
facility: Oakland Medical Center
state: Michigan
city: Waterford
country: United States
facility: Waterford Medical Assoc. P.C.
state: Michigan
city: Ypsilanti
country: United States
facility: Michigan Heart, PC
state: Michigan
city: Duluth
country: United States
facility: Duluth Clinic / Saint Marys Medical Center
state: Minnesota
city: Minneapolis
country: United States
facility: University of Minnesota
state: Minnesota
city: St. Paul
country: United States
facility: Regions Hospital
state: Minnesota
city: Gulfport
country: United States
facility: New Coast Cardiology Center, PLLC
state: Mississippi
city: Chesterfield
country: United States
facility: PPS Clinical Research, STL, LLC
state: Missouri
city: Kansas City
country: United States
facility: Kansas City VA Medical Center
state: Missouri
city: St. Louis
country: United States
facility: Cardiology Diagnostics, Ltd.
state: Missouri
city: Kalispell
country: United States
facility: Glacier View Cardiology
state: Montana
city: Missoula
country: United States
facility: Saint Patrick Hospital- International Heart Institute of Montana
state: Montana
city: Omaha
country: United States
facility: The Creighton Cardiac Center
state: Nebraska
city: Papillion
country: United States
facility: Alegent Health Clinic Heart and Vascular Specialist
state: Nebraska
city: Las Vegas
country: United States
facility: Nevada Cardiology Associates
state: Nevada
city: Nashua
country: United States
facility: Lahey Cardiology @ the Medical Center
state: New Hampshire
city: Cherry Hill
country: United States
facility: Associated Cardiovascular Consultants
state: New Jersey
city: Elmer
country: United States
facility: Cardiovascular Associates of the Delaware Valley, P.A.
state: New Jersey
city: Haddon Heights
country: United States
facility: Cardiovascular Associates of the Delaware Valley, P.A.
state: New Jersey
city: Sewell
country: United States
facility: Cardiovascular Associates of the Delaware Valley, P.A.
state: New Jersey
city: Toms River
country: United States
facility: Physicans Research Center, LLC
state: New Jersey
city: Albany
country: United States
facility: Capital Cardiology Associates
state: New York
city: Bronx
country: United States
facility: Cardiac Care and Vascular Medicine, Albert Einstein College of Medicine
state: New York
city: Cortlandt Manor
country: United States
facility: Hudson Valley Cardiology Group, P.C.
state: New York
city: Johnson City
country: United States
facility: Cardiology Associates, P.C.
state: New York
city: Mineola
country: United States
facility: Long Island Heart Associates
state: New York
city: New Hartford
country: United States
facility: Slocum-Dickson Medical Group, PLLC
state: New York
city: New Rochelle
country: United States
facility: Sound Shore Cardiology, P.C.
state: New York
city: New York
country: United States
facility: New York Cardiovascular Associate
state: New York
city: New York
country: United States
facility: St. Luke's- Roosevelt Hospital
state: New York
city: Rochester
country: United States
facility: Rochester General Hospital
state: New York
city: Saratoga Springs
country: United States
facility: Saratoga Cardiology Assoc, PC
state: New York
city: Scarsdale
country: United States
facility: Westchester Cardiology Associates
state: New York
city: Suffern
country: United States
facility: Good Samaritan Hospital
state: New York
city: Syracuse
country: United States
facility: Cardiology, PC
state: New York
city: Syracuse
country: United States
facility: SUNY Upstate Medical University
state: New York
city: Troy
country: United States
facility: Capital Cardiology Associates
state: New York
city: Williamsville
country: United States
facility: Buffalo Cardiology and Pulmonary Associates
state: New York
city: Williamsville
country: United States
facility: Mark J. Kozinn, MD
state: New York
city: Asheville
country: United States
facility: Clinical Study Center of Asheville, LLC
state: North Carolina
city: Burlington
country: United States
facility: Kernodle Clinic, Inc.
state: North Carolina
city: Charlotte
country: United States
facility: Metrolina Medical Research
state: North Carolina
city: Durham
country: United States
facility: Diversified Research
state: North Carolina
city: Fayetteville
country: United States
facility: Cumberland Research Associates, LLC
state: North Carolina
city: Oxford
country: United States
facility: Cardiovascular Care of Northern Carolina
state: North Carolina
city: Bismarck
country: United States
facility: St. Alexius Medical Center
state: North Dakota
city: Grand Forks
country: United States
facility: Altru Health Systems
state: North Dakota
city: Minot
country: United States
facility: Trinity Health
state: North Dakota
city: Boardman
country: United States
facility: George G. Ellis, Jr. M.D., Inc.
state: Ohio
city: Canton
country: United States
facility: Cardiovascular Research Institute, LLC
state: Ohio
city: Cincinnati
country: United States
facility: Comprehensive Cardiology Consultants, Inc.
state: Ohio
city: Columbus
country: United States
facility: Midwest Cardiology Research Foundation
state: Ohio
city: Franklin
country: United States
facility: Prestige Clinical Research
state: Ohio
city: Toledo
country: United States
facility: St. Vincent Mercy Medical Center
state: Ohio
city: Zanesville
country: United States
facility: Cardiology Associates of SE Ohio, Inc
state: Ohio
city: Zanesville
country: United States
facility: Physicans Research, Inc.
state: Ohio
city: Bartlesville
country: United States
facility: Bluestem Cardiology Research Dept.
state: Oklahoma
city: Oklahoma City
country: United States
facility: Oklahoma Cardiovascular Research Group
state: Oklahoma
city: Yukon
country: United States
facility: Aquilo Research
state: Oklahoma
city: Bend
country: United States
facility: Bend Memorial Clinic
state: Oregon
city: Hillsboro
country: United States
facility: Hillsboro Cardiology, PC
state: Oregon
city: Portland
country: United States
facility: Legacy Clinical Research
state: Oregon
city: Abington
country: United States
facility: Abington Medical Specialists
state: Pennsylvania
city: Beaver
country: United States
facility: Tri-State Medical Group
state: Pennsylvania
city: Camp Hill
country: United States
facility: Heritage Cardiology Association
state: Pennsylvania
city: Easton
country: United States
facility: Premier Heart Specialists
state: Pennsylvania
city: Ephrata
country: United States
facility: Heart Specialists of Lancaster
state: Pennsylvania
city: Hershey
country: United States
facility: Penn State Hershey Medical Center
state: Pennsylvania
city: Jenkintown
country: United States
facility: Pennsylvania Heart and Vascular Group, P.C.
state: Pennsylvania
city: Langhorne
country: United States
facility: Comprehensive Cardiology Consultants
state: Pennsylvania
city: Leetsdale
country: United States
facility: Sewickley Valley Medical Group Cardiology
state: Pennsylvania
city: Norristown
country: United States
facility: Cardiology Consultants of Philadelphia
state: Pennsylvania
city: Philadelphia
country: United States
facility: Hospital of the University of Pennsylvania Cardiology Department
state: Pennsylvania
city: Philadelphia
country: United States
facility: Cardiology Consultants of Philadelphia
state: Pennsylvania
city: Philadelphia
country: United States
facility: Albert Einstein Medical Center
state: Pennsylvania
city: Philadelphia
country: United States
facility: Cardiology Consultants of Philadelphia
state: Pennsylvania
city: Pittsburgh
country: United States
facility: VA Pittsburgh Healthcare System
state: Pennsylvania
city: Scranton
country: United States
facility: Advanced Cardiology Specialists
state: Pennsylvania
city: Sellersville
country: United States
facility: Elite Medical Research, Inc.
state: Pennsylvania
city: Upland
country: United States
facility: Cardiology Consultants of Philadelphia
state: Pennsylvania
city: West Chester
country: United States
facility: West Chester Cardiology, PC
state: Pennsylvania
city: Wyomissing
country: United States
facility: Berks Cardiology, Ltd.
state: Pennsylvania
city: Yardley
country: United States
facility: Cardiology Consultants of Philadelphia
state: Pennsylvania
city: Cranston
country: United States
facility: New England Center for Clinical Research&comma; Inc
state: Rhode Island
city: Providence
country: United States
facility: Rhode Island Hospital Cardiology
state: Rhode Island
city: Westerly
country: United States
facility: Cardiology Specialists
state: Rhode Island
city: Summerville
country: United States
facility: Palmetto Clinical Research
state: South Carolina
city: Athens
country: United States
facility: McMinn Medical Group (DBA: Athens Medical Group)
state: Tennessee
city: Bartlett
country: United States
facility: Verzosa & Ungab Internal Medicine Associates
state: Tennessee
city: Fayetteville
country: United States
facility: Middle Tennessee Clinical Research
state: Tennessee
city: Jackson
country: United States
facility: Research Associates of Jackson and Apex Cardiology
state: Tennessee
city: Johnson City
country: United States
facility: Tri-State Cardiology
state: Tennessee
city: Memphis
country: United States
facility: Memphis Internal Medicine
state: Tennessee
city: Memphis
country: United States
facility: Goodlife Medical Center
state: Tennessee
city: Nashville
country: United States
facility: Heart and Vascular Clinic
state: Tennessee
city: Arlington
country: United States
facility: Family Health Care Assoc.
state: Texas
city: Beaumont
country: United States
facility: Southeast Texas Clinical Research Center
state: Texas
city: Carrollton
country: United States
facility: Trinity Hypertension and Diagnostic Res.
state: Texas
city: Dallas
country: United States
facility: VA Medical Center
state: Texas
city: Dallas
country: United States
facility: U.T. Southwestern
state: Texas
city: Fort Worth
country: United States
facility: Amir Malik Research
state: Texas
city: Galveston
country: United States
facility: The University of Texas Medical Branch at Galveston
state: Texas
city: Houston
country: United States
facility: East Texas Cardiology PA
state: Texas
city: Houston
country: United States
facility: Office of Amer Zaheer, MD
state: Texas
city: Houston
country: United States
facility: Office of Salim Gopalani, MD
state: Texas
city: Houston
country: United States
facility: Comprehensive Heart Care, PA
state: Texas
city: Houston
country: United States
facility: Century Clinical Research
state: Texas
city: Houston
country: United States
facility: Office of Mizra Basith Baig, MD
state: Texas
city: Lubbock
country: United States
facility: Covenant Cardiology Associates
state: Texas
city: Mcallen
country: United States
facility: South Texas Institutes of Health
state: Texas
city: Plano
country: United States
facility: Texas Regional Heart Center d/b/a Legacy Heart Center
state: Texas
city: San Antonio
country: United States
facility: Heart & Vascular Institute of Texas
state: Texas
city: San Antonio
country: United States
facility: Cardiology Clinic of San Antonio
state: Texas
city: San Antonio
country: United States
facility: South Texas Cardiovascular Consultants
state: Texas
city: San Antonio
country: United States
facility: IMED Research, PA
state: Texas
city: Sugar Land
country: United States
facility: Southwest Health Associate, PA
state: Texas
city: Sugarland
country: United States
facility: Office of Dwayne O. Williams, MD
state: Texas
city: Temple
country: United States
facility: Kings Daughters Clinic
state: Texas
city: Victoria
country: United States
facility: Victoria Heart and Vascular Center
state: Texas
city: Danville
country: United States
facility: Cardiology Consultants of Danville
state: Virginia
city: Galax
country: United States
facility: Triad Research Institute
state: Virginia
city: Richmond
country: United States
facility: Virginia Cardiovascular Specialists
state: Virginia
city: Winchester
country: United States
facility: Winchester Medical Center/ Clinical Research Department
state: Virginia
city: Burien
country: United States
facility: Daniel W. Gottlieb, MD, PS
state: Washington
city: Spokane
country: United States
facility: Heart Clinic Northwest
state: Washington
city: Spokane
country: United States
facility: Inland Cardiology Assocaites
state: Washington
city: Tacoma
country: United States
facility: Franciscan Health System dba FHS Research Center
state: Washington
city: Parkersburg
country: United States
facility: Parkersburg Cardiology Associates
state: West Virginia
city: Madison
country: United States
facility: Wisconsin Heart, S.C.
state: Wisconsin
city: Milwaukee
country: United States
facility: Heart Care Associates, LLC
state: Wisconsin
city: Garran
country: Australia
facility: The Canberra Hospital
state: Australian Capital Territory
city: Coffs Harbour
country: Australia
facility: Coffs Harbour Cardiology
state: New South Wales
city: Eastwood
country: Australia
facility: Cardiac Research Institute
state: New South Wales
city: Auchenflower
country: Australia
facility: Wesley research institute
state: Queensland
city: Cairns
country: Australia
facility: Cairns Base Hospital
state: Queensland
city: Herston
country: Australia
facility: Royal Brisbane and Women's Hospital
state: Queensland
city: Hobart
country: Australia
facility: Royal Hobart Hospital
state: Tasmania
city: Launceston
country: Australia
facility: Launceston General Hospital
state: Tasmania
city: Epping
country: Australia
facility: Northern Hospital
state: Victoria
city: Fitzroy
country: Australia
facility: St.Vincent's Hospital (Melb)
state: Victoria
city: Geelong
country: Australia
facility: Geelong Hospital- Barwon Health
state: Victoria
city: Fremantle
country: Australia
facility: Fremantle Hospital
state: Western Australia
city: Dimitrovgrad
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment "Sveta Ekaterina", 1st Department of Internal Diseases
city: Pleven
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment "Dr. Georgi Stranski, Clinic of Cardiology
city: Plovdiv
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment ''Sveti Georgi'', Cardiology Clinic
city: Plovdiv
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment ''Sveti Panteleymon'', 2nd Department. of Internal Diseases - Intensive Cardiology Unit
city: Rousse
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment - Ruse, 4th Department of Internal Diseases
city: Sofia
country: Bulgaria
facility: 4th Multiprofile Hospital for Active Treatment
city: Sofia
country: Bulgaria
facility: Military Medical Academy, Clinic of Cardiology and Intensive Care
city: Sofia
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment and Emergency Medicine "Pirogov". Cardiology Clinic
city: Sofia
country: Bulgaria
facility: National Heart Hospital Department of Cardiology
city: Sofia
country: Bulgaria
facility: National Multiprofile Transport Hospital "Tsar Boris III, Cardiology Clinic
city: Sofia
country: Bulgaria
facility: Tokuda Hospital Department of Cardiology
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatment ''Tsaritsa Ioanna'' - ISUL, Cardiology Clinic
city: Varna
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment "Sveta Marina", Clinic of Internal Diseases - 2nd Internal Department
city: Maple Ridge
country: Canada
facility: Dr. Tsui
state: British Columbia
city: New Westminster
country: Canada
facility: Fraser Clinical Trials Inc and Royal Columbian Hospital
state: British Columbia
city: Vancouver
country: Canada
facility: Vancouver General Hospital
state: British Columbia
city: Victoria
country: Canada
facility: Victoria Heart Institute Foundation
state: British Columbia
city: Winnipeg
country: Canada
facility: Health Sciences Centre
state: Manitoba
city: Moncton
country: Canada
facility: South East Regional Health Authority
state: New Brunswick
city: Mount Pearl
country: Canada
facility: Commonwealth Medical Clinic
state: Newfoundland and Labrador
city: Cambridge
country: Canada
facility: Cambridge Cardiac Care Centre
state: Ontario
city: Mississauga
country: Canada
facility: Mississauga Clinical Research Center
state: Ontario
city: Niagara Falls
country: Canada
facility: Dr. George Zimakas
state: Ontario
city: Oshawa
country: Canada
facility: Dr. James Y. Cha
state: Ontario
city: Thunder Bay
country: Canada
facility: Curans Health Center
state: Ontario
city: Toronto
country: Canada
facility: Toronto East Cardiology Associates Inc.
state: Ontario
city: Granby
country: Canada
facility: Recherches Cliniques Theradev
state: Quebec
city: Greenfield Park
country: Canada
facility: ViaCar Recherche Clinique Inc.
state: Quebec
city: Longueuil
country: Canada
facility: ViaCar Recherche Clinique Inc
state: Quebec
city: Montreal
country: Canada
facility: Hospitalier de l'Universite de Montreal Hotel Dieu
state: Quebec
city: Montreal
country: Canada
facility: Sacre-Coeur Hospital
state: Quebec
city: St. Charles-Borromee
country: Canada
facility: Centre de Sante et de services sociaux du nord de lanaudiere/CHRDL
state: Quebec
city: St. George
country: Canada
facility: Centre Hospitalier Beauce-Etchemin
state: Quebec
city: Trois Rivieres
country: Canada
facility: Clinique de Cardiologie de Trois-Rivieres
state: Quebec
city: Westmount
country: Canada
facility: Cardiology and Research
state: Quebec
city: Quebec
country: Canada
facility: Centre Hospitalier Universitaire de Quebec (CHOQ) Hotel Dieu de Quebec
city: Quebec
country: Canada
facility: Laval Hospital
city: Antofagasta
country: Chile
facility: Clinica Antofagasta
city: Osorno
country: Chile
facility: Corporación de Beneficencia Osorno
city: Punta Arenas
country: Chile
facility: Hospital Regional de Punta Arenas Dr. Lautaro Navarro
city: Santiago
country: Chile
facility: Complejo Asistencial Dr.Sótero del Río
city: Santiago
country: Chile
facility: Hospital del Salvador
city: Santiago
country: Chile
facility: Instituto Nacional del Tórax
city: Temuco
country: Chile
facility: Centro de Estudios Cardiovascular
city: Viña del Mar
country: Chile
facility: Clínica Reñaca
city: Viña del Mar
country: Chile
facility: Hospital Dr. Gustavo Fricke
city: Viña del Mar
country: Chile
facility: Hospital Naval Almirante Neff
city: Frydek-Mistek
country: Czech Republic
facility: Nemocnice ve Frydku-Mistku
city: Hradec Kralove
country: Czech Republic
facility: Fakultni nemocnice Hradec Kralove
city: Liberec
country: Czech Republic
facility: Krajska nemocnice Liberec, a. s.
city: Litomysl
country: Czech Republic
facility: Litomyslska nemocnice a. s.
city: Ostrava Vítkovice
country: Czech Republic
facility: Kardiologicka a angiologicka ambulance
city: Ostrava
country: Czech Republic
facility: Kardiologická ambulance
city: Pardubice
country: Czech Republic
facility: Pardubicka krajska nemocnice, a.s.
city: Praha 2
country: Czech Republic
facility: II.interni klinika kardiologie a angiologie 1. LF UK a VFN v Praze
city: Praha 4
country: Czech Republic
facility: Klinika kardiologie Institut klinické a experimentální medicíny
city: Zlín
country: Czech Republic
facility: Krajská nemocnice T. Bati a.s.
city: Znojmo
country: Czech Republic
facility: Nemocnice Znojmo, p.o.
city: Albi
country: France
facility: Centre Hospitalier d'Albi
city: Dijon Cedex
country: France
facility: Centre de Cardiologie CHRU Dijon
city: Essey les Nancy Cedex
country: France
facility: Clinique Pasteur
city: Lille Cedex
country: France
facility: CHRU de Lille Hôpital Cardiologique
city: Marseille
country: France
facility: Hôpital La Timone-Adultes
city: Paris Cedex 13
country: France
facility: La Pitié Salpétrière Institut de Cardiologie
city: Paris
country: France
facility: Hôpital Lariboisière
city: St Jean de Verges
country: France
facility: Centre Hospitalier Intercommunal du Val d'Ariège
city: Toulouse Cedex 4
country: France
facility: Centre Hospitalier Rangueil Larrey
city: Berlin
country: Germany
facility: Universitatsklinikum Berlin Campus Charite Mitte Med Klinik Kardiologie und Angiologie
city: Berlin
country: Germany
facility: Vivantes Clinic Neuköln Berlin
city: Berlin
country: Germany
facility: Vivantes Humbolt Klinikum
city: Biberach
country: Germany
facility: Praxis Dr. med. Boscher
city: Bochum
country: Germany
facility: St. Josef-Hospital Medizinische Klinik II, Kardiologie
city: Bonn-Lengsdorf
country: Germany
facility: Dr. THomas Klingenheben
city: Bonn
country: Germany
facility: St.-Marien-Hospital Bonn
city: Brandenburg
country: Germany
facility: Städtisches Klinikum Brandenburg GmbH
city: Chemnitz
country: Germany
facility: MVZ am Küchwald GmbH
city: Dinslaken
country: Germany
facility: Gemeinschaftspraxis Innere Medizin und Kardiologie
city: Dortmund
country: Germany
facility: St.-Johannes-Hospital Dortmund
city: Dresden
country: Germany
facility: Zentrum für klinische Prüfungen in der Facharztzentrum Dresden Neustadt GbR
city: Erfurt
country: Germany
facility: Practice of Cardiology
city: Essen
country: Germany
facility: Elisabeth.Krankenhaus
city: Hamburg
country: Germany
facility: Asklepios Klinik St.Georg
city: Hamburg
country: Germany
facility: Asklepios Klinik Barmbek
city: Hamburg
country: Germany
facility: Universitäres Herz-und Gefäßzentrum Hamburg"
city: Hamburg
country: Germany
facility: Kardiologische Praxis Hamburg Altona
city: Hannover
country: Germany
facility: Klinikum Region Hannover Krankenhaus Nordstadt
city: Hartmannsdorf
country: Germany
facility: Kardiologische Gemeinschaftspraxis
city: Karlsbad
country: Germany
facility: SRH Klinikum Karlsbad-Langensteinbach
city: Koln
country: Germany
facility: Kliniken der Stadt Köln, Köln Merheim
city: Lahr
country: Germany
facility: Herzzentrum Lahr
city: Leipzig
country: Germany
facility: Kardiologische Gemeinschaftpraxis
city: Leipzig
country: Germany
facility: Universität Leipzig - Herzzentrum
city: Ludwigshafen
country: Germany
facility: Praxis für Innere Medizin, Gastroenterologie
city: Lübeck
country: Germany
facility: Universitätsklinikum Lübeck
city: Lüneburg
country: Germany
facility: Gemeinschaftspraxis
city: Mainz
country: Germany
facility: Klinikum der Johannes-Gutenberg-Universität
city: Mannheim
country: Germany
facility: Gemeinschaftspraxis
city: Mannheim
country: Germany
facility: Klinikum Mannheim GmbH, Universaitatskinikum
city: Markkleeberg
country: Germany
facility: Kardiologische Praxis
city: Melsungen
country: Germany
facility: Asklepios Klinik Melsungen
city: Mönchengladbach
country: Germany
facility: Kilniken Maria Hilf GmbH Krankenhaus St. Franziskus
city: Mühldorf a.d. Inn
country: Germany
facility: Internist/Kardiologe/Angiologe
city: Nienburg
country: Germany
facility: Kardiologische Gemeinschaftspraxis
city: Pirna
country: Germany
facility: Klinikum Pirna GmbH
city: Regensburg
country: Germany
facility: Universitätsklinik Regensburg
city: Reinbek
country: Germany
facility: Krankenhaus Reinbek St. Adolf-Stift
city: Riesa
country: Germany
facility: Kardiologische Gemeinschaftspraxis
city: Rottweil
country: Germany
facility: Internistische Praxis
city: Siegen
country: Germany
facility: Zentrum für Prävention und Rehabilation
city: Soest
country: Germany
facility: Marienkrankenhaus Soest
city: Stuhr
country: Germany
facility: Praxisgemeinschaft Stuhr-Brinkum
city: Tubingen
country: Germany
facility: Medizinische Universitätsklinik
city: Warendorf
country: Germany
facility: Josephs-Hospital Warendorf
city: Wermsdorf
country: Germany
facility: Kardiologische Praxis
city: Weyhe-Leeste
country: Germany
facility: Dr. Andreas Schreckenberg
city: Witten
country: Germany
facility: ForschungsZentrum Ruhr
city: Wuppertal
country: Germany
facility: Helios Klinikum Wuppertal
city: Baja
country: Hungary
facility: Bajai Kórház
city: Budapest
country: Hungary
facility: Budai Irgalmasrendi Kórház
city: Budapest
country: Hungary
facility: Fővárosi Önkormányzat Károlyi Sándor Kórház és Rendelőintézet
city: Budapest
country: Hungary
facility: Fovarosi Onkormanyzat Egyesitett Szent Istvan es Szent Laszlo Korhaz - Rendelointezet
city: Kalocsa
country: Hungary
facility: Városi Önkormányzat Kórház-Rendelőintézet
city: Nyíregyháza
country: Hungary
facility: Szabolcs-Szatmár-Bereg Megyei Önkormányzat Jósa András Oktató Kórház
city: Toszegi
country: Hungary
facility: Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház
city: Vác
country: Hungary
facility: Jávorszky Ödön Kórház
city: Zalaegerszeg
country: Hungary
facility: Zala Megyei Kórház
city: Bergamo
country: Italy
facility: Ospedali Riuniti di bergamo
city: Codogno (Lodi)
country: Italy
facility: Azienda Ospedaliera della Provincia di Lodi Presidio Ospedaliero di Codogno
city: Genova
country: Italy
facility: Azienda Ospedaliera Universitaria San Martino-Dipartimento di Medicina Interna e Specialità Mediche
city: Mantova
country: Italy
facility: Azienda Ospeedaliera Carlo Poma
city: Novara
country: Italy
facility: Azienda Ospedaliera Maggiore Della Carita' Di Novara
city: Rozzano (Milano)
country: Italy
facility: Istituto Clinico Humanitas
city: Guadalajara
country: Mexico
facility: Hospital "Valentín Gómez Farías"
state: Jalisco
city: San Luis Potosi
country: Mexico
facility: Cardioarritmias e Investigación, S.C.
state: San Lusi Potosi
city: Aguascalientes
country: Mexico
facility: Hospital Cardiológica Aguascalientes
city: D. F.
country: Mexico
facility: Hospital de Jesus
city: Durango
country: Mexico
facility: Cardioprevent
city: Puebla
country: Mexico
facility: Hospital Angeles de Puebla
city: Puebla
country: Mexico
facility: Hospital General de Puebla
city: Queretaro
country: Mexico
facility: Instituto de Corazón de Querétaro, S.A. de C.V.
city: San Luis Potosi
country: Mexico
facility: Hospital Central "Dr. Ignacio Morones Prieto"
city: Bydgoszcz
country: Poland
facility: Oddział Kardiologii z Zakładem Diagnostyki Kardiologicznej, Samodzielny Publiczny Zakład Opieki Zdrowotnej, Wojewódzki Szpital im. dr J. Biziela,
city: Bydgoszcz
country: Poland
facility: NZOZ "Medicus" Jacek Kubica
city: Bydgoszcz
country: Poland
facility: Wojewódzki Szpital Meijski im. Biziela, Oddział Kardiologii - SPZOZ
city: Dębica
country: Poland
facility: Oddział Chorób Wewnętrzych i Kardiologii , ZOZ w Debicy
city: Gdańsk
country: Poland
facility: Zakład Opieki Zdrowotnej Trójmiejskie Centrum Medyczne Sp. z o.o
city: Gdynia
country: Poland
facility: Gabinet Kardiologiczny Medipuls
city: Gdynia
country: Poland
facility: Gabinet Kardiologiczno-Internistyczny
city: Gdynia
country: Poland
facility: Centrum Leczenia Chorób Cywilizacyjnych Oddz. Gdynia filla Fikakowo
city: Gliwice
country: Poland
facility: NZOZ Medicus, Poradnia Kardiologiczna
city: Gliwice
country: Poland
facility: Oddział Kardiologii i INK, SPZOZ nr 1
city: Grodzisk Mazowiecki
country: Poland
facility: Mazowieckie Centrum Badań Klinicznych Iwona Czajkowska, Monika Śmietańska s.c.
city: Inowroclaw
country: Poland
facility: Publiczny Specjalistyczny Zaklad Opieki Zdrowotnej Oddzial Kardiologiczny
city: Katowice
country: Poland
facility: Oddział Chorób Wewnętrznych i Farmakologii Klinicznej Samodzielny Publiczny Centralny Szpital Kliniczny im. Prof. Kornela Gibińskiego Śląskiego Uniwersytetu Medycznego w Katowicach
city: Kościerzyna
country: Poland
facility: Szpital Specjalistyczny w Kościerzynie, Oddział Kardiologii
city: Krakow
country: Poland
facility: Oddział Kardiologii, Szpital Specjalistyczny im. J. Dietla
city: Krakow
country: Poland
facility: "Klinika Choroby Wieńcowej Instytut Kardiologii, Collegium Medicum Uniwerytet Jagielloński
city: Kraków
country: Poland
facility: Oddzial Chorób Wewnętrznych III Szpital Specjalistyczny im.Stefana Zeromskiego, SPZOZ w Krakowie
city: Kutno
country: Poland
facility: Niepubliczny Zakład Opieki Zdrowotnej Specjalista Sp. z o.o.
city: Limanowa
country: Poland
facility: Poradnia Kardiologiczna, Oddział Chorob Wewnetrznych Szpital Powiatowy w Limanowej
city: Lubartów
country: Poland
facility: Oddział Internistyczno-Kardiologiczny Samodzielny Publiczny Zakład Opieki Zdrowotnej
city: Mielec
country: Poland
facility: "Oddzial Chorob Wewnetrznych i Kardiologii, Szpital Powiatowy im.Edmunda Biernackiego
city: Nowa Sól
country: Poland
facility: Oddział Kardiologii, Nowa Sól
city: Olawa
country: Poland
facility: ZOZ w Oławie, Oddział Chorób Wewnętrznych
city: Olsztyn
country: Poland
facility: "Oddział Kardiologiczno-Internistyczny
city: Opole
country: Poland
facility: "Oddział Kardiologiczny Publiczny Samodzielny ZOZ Wojewódzkie Centrum Medyczne
city: Ostrów Wielkopolski
country: Poland
facility: Specjalistyczny Zakład Opieki Zdrowotnej Poradnia lekarzy specjalistów "Jantar"
city: Pabianice
country: Poland
facility: II Oddział Wewnętrzny Samodzielny Publiczny Zakład Opieki Zdrowotnej
city: Piotrków Trybunalski
country: Poland
facility: "Samodzielny Szpital Wojewódzki im. Mikołaja Kopernika, Oddział Kardiologiczny
city: Poznań
country: Poland
facility: Medyczne Centrum Hetmańska, Indywiualna Specjalistyczna Praktyka Lekarska, Dr n. med. Piotr Leszczyński
city: Poznań
country: Poland
facility: Specjalistyczne Centrum Diagnostyczno-Lecznicze Bamberski Dwór
city: Pruszków
country: Poland
facility: Oddział Wewnetrzny I, Szpital Kolejowy im. dr med. Włodzimierza Roeslera
city: Puławy
country: Poland
facility: Samodzileny Publiczny Zakład Opieki Zdrowotnej w Puławach, Szpital Specjalistyczny
city: Płock
country: Poland
facility: Wojewódzki Szpital Zespolony, Oddział Kardiologiczny
city: Płock
country: Poland
facility: Specjalistyczna Przychodnia Lekarska "Medikard"
city: Radom
country: Poland
facility: Zakład Hemodynamiki, Wojewódzki Szpital Specjalistyczny
city: Rzeszów
country: Poland
facility: "Oddział Kardiologii z Pododdziałem Ostrych Zespołów Wieńcowych i z Ośrodkiem Implantacji Rozruszników Serca,
city: Sandomierz
country: Poland
facility: Oddział Kardiologii, SP ZZOZ Sandomierz
city: Siedlce
country: Poland
facility: Oddział Kardiologiczny Wojewódzki Szpital Specjalistyczy w Siedlcach
city: Sieradz
country: Poland
facility: Oddział Kardiologii Samodzielny Publiczny Zakład Opieki Zdrowotnej w Sieradzu im. Kardynała Stefana Wyszyńskiego
city: Skierniewice
country: Poland
facility: "Oddział Kardiologii, Wojewódzki Szpital Zespolony w Skierniewicach, "
city: Skierniewice
country: Poland
facility: NZOZ Przychodnia Zadebie, Przychodnia Kardiologiczna
city: Stalowa Wola
country: Poland
facility: "Oddział Kardiologii Inwazyjnej i Angiologii z Pr. Hemodynamiki
city: Starogard Gdański
country: Poland
facility: Szpital Specjalistyczny Św.Jana, Oddział Kardiologii,
city: Szczecin
country: Poland
facility: Indywidualna Specjalistyczna Praktyka Lekarska
city: Tarnów
country: Poland
facility: Poradnia Kardiologiczna
city: Tarnów
country: Poland
facility: Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny-Cardiology
city: Torun
country: Poland
facility: Niepubliczny Zakład Opieki Zdrowotnej "Nasz Lekarz", Praktyka Grupowa Lekarzy Rodzinnych z Przychodnią Specjalistyczną
city: Toruń
country: Poland
facility: Oddział Kardiologii Wojewódzki Szpital Zespolony
city: Warszawa
country: Poland
facility: Oddział Kardiologiczny Szpital Wolski im. dr Anny Gostyńskiej Samodzielny Publiczny Zakład Opieki Zdrowotnej
city: Warszawa
country: Poland
facility: Samodzielny Publiczny Centralny Szpital Kliniczny Akademii Medycznej w Warszawie
city: Warszawa
country: Poland
facility: II Klinika Choroby Wieńcowej Instytutu Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego
city: Warszawa
country: Poland
facility: Centrum Leczenia Chorób Cywilizacyjnych
city: Warszawa
country: Poland
facility: Międzyleski Szpital Specjalistyczny w Warszawie
city: Warszawa
country: Poland
facility: NZOZ Starówka
city: Wałbrzych
country: Poland
facility: "Oddział Kardiologiczny Wałbrzyski Ośrodek Kardiologii Interwencyjnej Specjalityczny Szpital im. Dr Alfreda Sokołowskiego
city: Wroclaw
country: Poland
facility: Osrodek Chorob Serca, Klinika Kardiologii 4 Wojskowy Szpital Kliniczny z Poliklinika - Samodzielny Publiczny Zaklad Opieki Zdrowotnej
city: Wrocław
country: Poland
facility: Synexus SCM Sp.z o o.
city: Wrocław
country: Poland
facility: Niepubliczny Zakład Opieki Zdrowotnej, Centrum Badań Klinicznych
city: Zabrze
country: Poland
facility: "Śląskie Centrum Chorób Serca, III Katedra i Oddział Kliniczny Kardiologii Śląskiego Uniwersytetu Medycznego
city: Łomża
country: Poland
facility: Oddział Kardiologiczny Szpital Wojewódzki im. Kardynała Stefana Wyszyńskiego
city: Łódź
country: Poland
facility: Niepubliczny Zakład Opieki Zdrowotnej POLIMEDICA
city: Łódź
country: Poland
facility: All-Med Centrum Medyczne
city: Ponce
country: Puerto Rico
facility: Research and Cardiovascular Corp.
city: Bacau
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Bacau
city: Bucharest
country: Romania
facility: S.C. Duo Medical S.R.L.
city: Bucharest
country: Romania
facility: Cardiomed SRL
city: Bucuresti
country: Romania
facility: Centrul Medical SANA
city: Cluj-Napoca
country: Romania
facility: Institutul Inimii "Niculae Stanicioiu"
city: Craiova
country: Romania
facility: Cardiomed SRL
city: Iasi
country: Romania
facility: Dr. C.I. Parhon Hospital
city: Sibiu
country: Romania
facility: Clinical county Hospital
city: Targu Mures
country: Romania
facility: Institutul de Boli Cardiovasculare si Transplan Tg. Mures
city: Timisoara
country: Romania
facility: County Hospital
city: Banská Bystrica
country: Slovakia
facility: Novamed s.r.o.
city: Bardejov
country: Slovakia
facility: Alian s.r.o.
city: Bratislava
country: Slovakia
facility: 5. Interna klinika LF UK, FNsP Bratislava, Nemocnica Ruzinov
city: Kosice
country: Slovakia
facility: Cardio D&R spol. s r.o.
city: Lučenec
country: Slovakia
facility: Kardiomed s.r.o.
city: Nitra
country: Slovakia
facility: NZZ Kardiocentrum Nitra s.r.o.
city: Nove Zamky
country: Slovakia
facility: MUDr. Tibor DURIS, CSc., s.r.o.
city: Považská Bystrica
country: Slovakia
facility: Nemocnica s poliklinikou Považská Bystrica
city: Trencin
country: Slovakia
facility: Fakultna Nemocnica Trencin
city: Žilina
country: Slovakia
facility: Žilpo s.r.o.
city: Žilina
country: Slovakia
facility: Medivasa s.r.o.
city: Dnipropetrovsk
country: Ukraine
facility: "Klinichne obyednannia shvydkoi medychnoi dopomogy, m. Dnipropetrovs'k,Dnipropetrovs'ka derzhavna medychna akademiya, kafedra gospital'noi terapii #2
city: Ivano-Frankivsk
country: Ukraine
facility: Oblasnyi klinichnyi kardiologichnyi dyspanser, m. Ivano-Frankivsk, Ivano-Frankivskyi derzhavnyi medychnyi universytet, kafedra terapii # 3
city: Kyiv
country: Ukraine
facility: TOV "Kardiologichna klinika "Sertse i sudyny" m. Kyiv
city: Kyiv
country: Ukraine
facility: Natsionalnyi naukovyi tsentr "Instytut kardiologii im. akad. M.D. Strazheska" AMN Ukrainy, m. Kyiv, viddilenia symptomatychnykh arterial'nykh gipertenziy
city: Kyiv
country: Ukraine
facility: Natsionalnyi naukovyi tsentr "Instytut kardiologii im. akad. M.D. Strazheska", viddil reanimatsii ta intensyvnoi terapii, m. Kyiv
city: Zaporizhzhya
country: Ukraine
facility: Komunal'na ustanova "Oblasnyi kardiologichnyi dyspanser", viddilenia intensyvnoi terapii, m. Zaporizhzhia
city: Zhytomyr
country: Ukraine
facility: Kardioarytmologichnyi tsentr Zhytomyrs'koi oblasnoi klinichnoi likarni im. O.F. Gorbachevs'kogo, m. Zhytomyr
Study officials:
affiliation: Cogentus Pharmaceuticals
name: Pablo Lapuerta, MD
role: STUDY_DIRECTOR
References:
citation: Vaduganathan M, Bhatt DL, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Cannon CP; COGENT Investigators. Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. J Am Coll Cardiol. 2016 Apr 12;67(14):1661-71. doi: 10.1016/j.jacc.2015.12.068. Epub 2016 Mar 21.
citation: Bhatt DL, Cryer BL, Contant CF, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Scirica BM, Murphy SA, Cannon CP; COGENT Investigators. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med. 2010 Nov 11;363(20):1909-17. doi: 10.1056/NEJMoa1007964. Epub 2010 Oct 6.