Clinical trial NCT04950179: PDRI Rates Among CAPD Patients at a Tertiary University Hospital: A 5-Year Retrospective Study
Official title: Peritoneal Dialysis-Related Infection Rates and Outcomes of Antibiotic Treatments Among Continuous Ambulatory Peritoneal Dialysis Patients at a Tertiary University Hospital: A 5-Year Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Peritoneal Dialysis-related Infection
Keywords: Peritoneal dialysis-related infection
Infectious peritonitis
Exit-site infection
Tunnel infection
Infection rate
Lead sponsor: Phramongkutklao College of Medicine and Hospital
Sponsor class: OTHER
Collaborators: name: Silpakorn University
First posted: 2021-07-06
Enrollment: 135
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who were undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD) at CAPD clinic, Phramongkutklao Hospital.

Brief summary: Peritoneal dialysis-related infection is a complication that leads to peritoneal dialysis catheter removal or patient death. The present study aimed to investigate peritoneal dialysis-related infection rates, causative pathogens, appropriation of antibiotic use, treatment outcomes and trend in antimicrobial resistance of causative pathogens.


Eligibility criteria: Inclusion Criteria:

1. Patients who were at least 18 years old.
2. Patients who were diagnosed with stage 5 chronic kidney disease (eGFR \< 15 ml/min/1.73m\^2).
3. Patients who were undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD) at CAPD clinic, Phramongkutklao Hospital during January 1, 2016 to December 31, 2020.

Exclusion Criteria:

1. Patients with incomplete data records that invalid to include in the process of data analysis
2. Patients who were not treated and started their first CAPD at CAPD clinic, Phramongkutklao Hospital.

Primary outcomes:
measure: Rate of peritoneal dialysis-related infection
timeFrame: January 1, 2016 to December 31, 2020
measure: Treatment outcomes of peritoneal dialysis-related infection
timeFrame: January 1, 2016 to December 31, 2020
Secondary outcomes:
measure: Causative pathogens of peritoneal dialysis-related infection
timeFrame: January 1, 2016 to December 31, 2020
measure: Appropriation of antibiotic use in the treatments of peritoneal dialysis-related infection
timeFrame: January 1, 2016 to December 31, 2020
Other outcomes:
Locations:
city: Ratchathewi
country: Thailand
facility: Phramongkutklao Hospital
state: Bangkok
Study officials:
affiliation: Phramongkutklao Hospital and College of Medicine
name: Pamila Tasanavipas, MD
role: STUDY_CHAIR
affiliation: Faculty of Pharmacy, Silpakorn University
name: Daraporn Rungprai, BCP
role: STUDY_DIRECTOR
affiliation: Faculty of Pharmacy, Silpakorn University
name: Vorada Pengsong
role: PRINCIPAL_INVESTIGATOR
affiliation: Faculty of Pharmacy, Silpakorn University
name: Vattanai Dhamnimitchok
role: PRINCIPAL_INVESTIGATOR
affiliation: Faculty of Pharmacy, Silpakorn University
name: Vilai Wisuthip
role: PRINCIPAL_INVESTIGATOR
affiliation: Faculty of Pharmacy, Silpakorn University
name: Supichaya Hluangbumroong
role: PRINCIPAL_INVESTIGATOR
References:
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