louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04087603: Teen Sleep Health Study
Official title: Teen School-Night Sleep Extension: An Intervention Targeting the Circadian System
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sleep Disorders, Circadian Rhythm
Adolescent Behavior
Keywords: Circadian rhythms
Sleep
Adolescence
Lead sponsor: Rush University Medical Center
Sponsor class: OTHER
First posted: 2019-09-12
Enrollment: 52
Sex: ALL
Minimum age (years): 14
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this project is to develop an effective, yet feasible strategy to extend school-night sleep duration of older adolescents.

Detailed description: The investigators are developing and testing a feasible behavioral intervention to increase school-night sleep duration by shifting the circadian system earlier and providing a time management plan for after-school activities in youngsters between 14 and 17 years and enrolled in high school. This study tests morning bright light and a school-night time management plan to facilitate earlier bedtimes to increase sleep duration. Circadian phase, sleep, neurobehavioral functioning and mood are measured before and immediately after the 2-week intervention and compared to a control group. Long-term effectiveness, adherence, and acceptability are also examined in a 3-week extension study. These data will provide evidence-based treatment strategies for delayed and sleep-restricted adolescents, and acceptability of and adherence to the treatment in this age group.

Eligibility criteria: Inclusion Criteria:

* 14- 17 years; enrolled in high school; lives in or near Chicago, IL

Exclusion Criteria:

-

Primary outcomes:
measure: Change in circadian phase
timeFrame: Saturday evening before and Saturday evening after the 2-week intervention
measure: Change in sleep duration
timeFrame: 2-week baseline period and 2-week intervention period
measure: Change in daytime sleepiness
timeFrame: Saturday before and Saturday after the 2-week intervention
measure: Change in daytime vigilance/attention
timeFrame: Saturday before and Saturday after the 2-week intervention
measure: Change in inhibitory control
timeFrame: Saturday before and Saturday after the 2-week intervention
measure: Change in cognitive processing
timeFrame: Saturday before and Saturday after the 2-week intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
Study officials:
References:
Clinical trial NCT01670903: The Effect of Angiotensin II Type 1 Receptor Antagonists on the Size and Expansion Rate of Abdominal Aortas in Hypertensive Patients
Official title: the Effect of Angiotensin II Type 1 Receptor Antagonists on the Size and Expansion Rate of Abdominal Aortas in Hypertensive Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Aneurysm
Hypertension
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2012-08-22
Enrollment: 150
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: medically treated hypertensive patients, ages 50-80

Brief summary: Abdominal aortic aneurysm (AAA) is a common disease that develops from degeneration of the aortic wall. The natural history of AAA is gradual expansion and if left untreated may result in rupture and death. The mechanism of the development of this disease is unknown however it appears to be multifactorial and possibly related to degradation processes within the arterial wall. There is growing evidence that Angiotensin receptor blockers ( ARBS) may have an inhibitory effect on remodelling processes within the arterial wall, thus inhibiting degeneration of the vessel wall.

Study hypothesis: ARBS are associated with smaller diameters of aortas among hypertensive patients, and are associated with a lower rate of aortic expansion compared to other antihypertensive drugs.


Eligibility criteria: Inclusion Criteria:

* medically treated hypertensive patients, ages 50-80

Exclusion Criteria:

* pregnant women
* patients previously treated for aortic disease
* unable to sign informed consent, minors

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Tel Hashomer
country: Israel
facility: Sheba Medical Center
city: Tel Hashomer
country: Israel
facility: Sheba Medical Center
Study officials:
affiliation: Sheba Medical Center
name: Daniel Silverberg, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05509803: PE Audit and Feedback Pilot Study
Official title: Increasing Compliance With Physical Education Laws to Reduce Health Inequities
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physical Inactivity
Cardiovascular Diseases
Lead sponsor: University of California, Berkeley
Sponsor class: OTHER
First posted: 2022-08-22
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This will be a 2-group cluster-randomized clinical trial, with the school being the unit of assignment and randomization. 5 schools will receive an intervention and 5 schools will serve as controls.
Primary purpose: PREVENTION

Brief summary: School physical education (PE) is one of the most valuable tools for increasing physical activity and fitness among youth of all backgrounds; however, compliance with existing PE laws is low (and differential by school race/ethnic and family-income composition, contributing to health disparities), and best practices for increasing compliance remain unknown. This study proposes to examine a novel approach for increasing PE law compliance by testing a PE audit and feedback tool (adapted from a tool used by the New York City Department of Education) in Oakland, California schools to determine the effectiveness, adaptability, and scalability of this potential cost-effective approach for increasing PE law compliance and student physical activity.


Eligibility criteria: Inclusion Criteria:

* Elementary school in the Oakland Unified School District
* \>50% of students in the school qualify for free or reduced-price meals
* \>80% of students non-white

Exclusion Criteria:

* Having a PE program known by the PE Director to be well-established and/or meet/exceed district expectations for PE

Primary outcomes:
measure: Effectiveness
timeFrame: Baseline (12 weeks); Follow-up (12 weeks)
measure: Adoption
timeFrame: 20-30 minutes
measure: Implementation
timeFrame: 20-30 minutes
measure: Maintenance
timeFrame: 20-30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Berkeley
country: United States
facility: UC Berkeley
state: California
Study officials:
References:
Clinical trial NCT04244903: Prevalence of MLFA Types and MD in Egyptian Children With Erupted Canines
Official title: Prevalence of Maxillary Labial Frenal Attachments Types and Midline Diastema in Egyptian Children With Fully Erupted Maxillary Permanent Canines
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Destructive Attachment of Labial Frenum
Keywords: Midline diastema, Prevalence, Maxillary frenal types
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-01-28
Enrollment: 275
Sex: ALL
Minimum age (years): 9
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: This study will be conducted among Egyptian children with fully erupted canines, who regularly attend the outpatient clinic of pediatric dentistry department, Cairo University.

Brief summary: Descriptive observational cross sectional study Outpatient at faculty of dentistry Cairo university pediatric dentistry department clinic with midline diastema and fully erupted canines will be examined and assess type of frenal attachment to see if correlation present or not


Eligibility criteria: Inclusion Criteria:

* Systemically healthy children
* Egyptian children with fully erupted canines
* Patient presented for routine evaluation or treatment

Exclusion Criteria:

* Children who exhibited congenital anomalies or orofacial defects
* Children with previous trauma in frenal area which affect its morphology
* Children have previous surgical intervention in labial frenum or in the maxillary anterior region.
* Children have any syndromes or habits that affect the anterior maxillary region.

Primary outcomes:
measure: Incidence of Midline diastema
timeFrame: 1 year
Secondary outcomes:
measure: Frenal attachment types
timeFrame: 1 year
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentistry Cairo University
state: Giza
city: Giza
country: Egypt
facility: Asmaa Ahmed saad
Study officials:
References:
Clinical trial NCT06591403: INVESTIGATION OF PERIPHERAL OXYGEN SATURATION VALUES MEASURED IN DIFFERENT BODY POSITIONS AND FINGERS IN HEALTHY YOUNG ADULT INDIVIDUALS
Official title: INVESTIGATION OF PERIPHERAL OXYGEN SATURATION VALUES MEASURED IN DIFFERENT BODY POSITIONS AND FINGERS
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Peripheral Oxygen Saturation
Healthy Individuals
Keywords: Body Positions
Oxygenation
Pulse Oximetry
Lead sponsor: Uludag University
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 200
Sex: ALL
Minimum age (years): 19
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This study aims to examine peripheral oxygen saturation values measured in different body positions and fingers in healthy young adult individuals.

The research was planned in a quasi-experimental design. The research population consisted of students/healthy young adults studying at Bursa Uludağ University Faculty of Health Sciences between January 2024 and May 2024. The research sample consisted of a total of 200 volunteer individuals who met the research limitations.

The research data were collected using the Individual Introduction Form and Peripheral Oxygen Saturation Monitoring Form. A pulse oximeter was placed simultaneously on the index and middle fingers of each participant\&#39;s active hand while they were in an upright sitting position. After the pulse oximeter was placed on both fingers for one minute, stable values seen on its screen for at least three seconds were recorded. Then, the participants were placed in a supine position, and after a 10-minute rest, similar measurements were repeated with a pulse oximeter placed on the index and middle fingers of the active hand.


Eligibility criteria: Inclusion Criteria:

* participating voluntarily in the study
* being aged over 18 years
* not having any acute or chronic disease

Exclusion Criteria:

* being less than 18 years of age,
* having anemia,
* not wanting to participate in the study, or during the course of the research, wishing to withdraw from the study,
* having an oxygen saturation value of less than 90%,
* being unable to tolerate a 0° prone position (bradycardic).

Primary outcomes:
measure: heart rate
timeFrame: 5 months
measure: peripheral oxygen saturation
timeFrame: 5 months
Secondary outcomes:
measure: weight
timeFrame: 5 months
measure: height
timeFrame: 5 months
Other outcomes:
Locations:
city: Bursa
country: Turkey
facility: Bursa Uludag University Faculty of Health Sciences
state: Nilüfer
Study officials:
References:
Clinical trial NCT02020603: Efficacy of Hemostasis by Soft Coagulation Using Endoscopic Hemostatic Forceps for Acute Peptic Ulcer Bleeding
Official title: Efficacy of Hemostasis by Soft Coagulation Using Endoscopic Hemostatic Forceps in Comparison With Argon Plasma Coagulation for Acute Peptic Ulcer Bleeding
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Active Peptic Ulcer Disease/GI Bleeding
Keywords: peptic ulcer bleeding
hemostatic forceps
soft coagulation
argon plasma coagulation
Lead sponsor: Kyunghee University Medical Center
Sponsor class: OTHER
First posted: 2013-12-25
Enrollment: 151
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Endoscopic high-frequency soft coagulation is available for the management of bleeding or nonbleeding visible vessels during endoscopic submucosal dissection. However, its efficacy on peptic ulcer bleeding has not been elucidated so far. The aim of this study was to evaluate the efficacy of hemostasis with soft coagulation using hemostatic forceps by comparing it with argon plasma coagulation (APC) in a prospective, randomized trial.


Eligibility criteria: Inclusion Criteria:

* age greater than 18 years
* peptic ulcer with stigmata of recent hemorrhage

Exclusion Criteria:

* malignant ulcer
* previous gastric surgery

Primary outcomes:
measure: Recurrence of bleeding within four weeks after initial hemostasis
timeFrame: up to 24 months
Secondary outcomes:
measure: initial hemostasis rate
timeFrame: up to 24 months
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital
Study officials:
affiliation: Kyung Hee University Hospital
name: Jae Young Jang, M.D.
role: STUDY_CHAIR
References:
citation: Kim JW, Jang JY, Lee CK, Shim JJ, Chang YW. Comparison of hemostatic forceps with soft coagulation versus argon plasma coagulation for bleeding peptic ulcer--a randomized trial. Endoscopy. 2015 Aug;47(8):680-7. doi: 10.1055/s-0034-1391565. Epub 2015 Mar 2.
Clinical trial NCT01284803: Feasibility and Acceptability of an Educational Intervention to Improve the Management of Depression in Primary Care.
Official title: Feasibility and Acceptability of an Educational Intervention to Improve the Management of Depression in Primary Care
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Patients With Moderate Depression,
First or Second Episode
Keywords: patients
moderate depression
Lead sponsor: Assistance Publique Hopitaux De Marseille
Sponsor class: OTHER
First posted: 2011-01-27
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP

Brief summary: Qualitative study based on interviews and questionnaires with patients participating to an educational intervention to improve the management of depression in primary care.

Objective is to assess feasibility and acceptability of an educational intervention to improve the management of depression in primary care To elaborate an educational program for the management of depression in primary care.

Detailed description: To assess feasibility and acceptability of an educational intervention to improve the management of depression in primary care To elaborate an educational program for the management of depression in primary care.

And perspectives are to elaborate an educational intervention to care depression in primary care

Eligibility criteria: Inclusion Criteria:

* age between 18-65y
* moderate depression (CIM 10)
* first or second episode
* able to read and understand French language

Exclusion Criteria:

* psychotic symptoms
* severe depression
* bipolar disorder
* suicide risk
* substance abuse

Primary outcomes:
measure: Qualitative study
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Marseille
country: France
facility: Assistance Publique - Hopitaux de Marseille
Study officials:
affiliation: APHM
name: Christophe Lancon, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01187303: Ofatumumab in Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)
Official title: Ofatumumab in Relapsed Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Relapsed NLPHL
Lead sponsor: University of Cologne
Sponsor class: OTHER
First posted: 2010-08-24
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this trial is to determine the efficacy of ofatumumab in patients with relapsed nodular lymphocyte predominant Hodgkin lymphoma (NLPHL).


Eligibility criteria: Inclusion Criteria:

* relapsed nodular lymphocyte predominant hodgkin lymphoma
* age 18 - 75
* review of diagnosis by experienced pathologist
* no major organ dysfunction

Exclusion Criteria:

* classical hodgkin lymphoma
* CD20 antibody treatment within the last 6 months prior enrollment
* chronic or current infectious disease requirering systemic antibiotics
* other past or current malignancy

Primary outcomes:
measure: Overall response rate
timeFrame: 12 months after end of treatment
Secondary outcomes:
measure: duration of response
timeFrame: 12 months after end of treatment
measure: Progression free survival
timeFrame: 12 months after end of treatment
measure: adverse events
timeFrame: 12 months after end of treatment
Other outcomes:
Locations:
city: Cologne
country: Germany
facility: 1st Department of Medicine, Cologne University Hospital
Study officials:
affiliation: University of Cologne
name: Andreas Engert, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04074603: Comparing the Effects of Insulin Glargine on Blood Glucose Between Needle-free Jet Injection and Insulin Pen
Official title: Comparing the Effects of Insulin Glargine on Peripheral Blood Glucose Between Needle-free Jet Injection and Conventional Insulin Pen
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Type 2 Diabetes
Keywords: Needle-free jet injection
Insulin glargine
Lead sponsor: Nanjing First Hospital, Nanjing Medical University
Sponsor class: OTHER
First posted: 2019-08-30
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: To comparing the blood sugar improvement and patient sensibility of insulin glargine injected with needle-free jet injector and conventional insulin pen

Detailed description: Compared with conventional pen, needle-free jet injection of insulin has faster flow rate and larger area of local subcutaneous absorption. The aim of this study was to investigate the effects of subcutaneous insulin glargine injection with needle-free jet injection and conventional pen on blood glucose profile and safety in type 2 diabetic patients.

Eligibility criteria: Inclusion Criteria:

* volunteer to participate and be able to sign informed consent prior to the trial.
* patients with type 2 diabetes, aged 18-80 years old, meeting WHO1999 diagnostic criteria, have not used any hypoglycemic drugs. The dosage of insulin glargine (4-35 units) combined with oral medicationis, stable for more than 2 months.
* No acute complications such as diabetic ketoacidosis, diabetic hyperosmolar syndrome, etc.
* Subjects are able and willing to monitor peripheral blood sugar and regularity of diet and exercise.

Exclusion Criteria:

* Patients with insulin allergy.
* Impaired liver and kidney function with ALT 2.5 times higher than the upper limit of normal value;Serum creatinine was 1.3 times higher than the upper limit of normal.
* Drug abuse and alcohol dependence in the past 5 years.
* Systemic hormone therapy was used in the last three months.
* Patients with poor compliance and irregular diet and exercise.
* Patients with pregnancy, lactation or pregnancy intention.
* Any other obvious conditions or associated diseases determined by the researcher: such as severe cardiopulmonary diseases, endocrine diseases, neurological diseases, tumors and other diseases, other pancreatic diseases, history of mental diseases.

Primary outcomes:
measure: Blood glucose changes
timeFrame: 2 weeks
measure: The glucose fluctuation
timeFrame: 2 weeks
Secondary outcomes:
measure: Assessment of safety and tolerance
timeFrame: 2 weeks
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Nanjing First Hospital
state: Jiangsu
Study officials:
References:
Clinical trial NCT01238003: Clinical Relevance of Anti-Neutrophil Cytoplasm Antibody (ANCA)in Hospitalized Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: ANCA-related Vasculitis
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2010-11-10
Enrollment: 380
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients hospitalized in internal medicine ward

Brief summary: Laboratory testing of Anti-Neutrophil Cytoplasm Antibody (ANCA) is used to confirm diagnosis of patients who have a high level of suspicion for ANCA-related vasculitis. In these patients the specificity and sensitivity to the ANCA test is very high. This study hopes to prove that when this lab test is performed on blood of patients who do not have a high level of suspicion for ANCA-related vasculitis, the sensitivity and specificity is reduced and there are many false positive results. Because of this, it should not be used as a screening test for a more general patient population.


Eligibility criteria: Inclusion Criteria:

* Blood samples sent for ANCA lab test

Exclusion Criteria:

* Patients with ANCA vasculitis
* Patients with known malignancy

Primary outcomes:
measure: Mostly negative lab results
timeFrame: One year
Secondary outcomes:
Other outcomes:
Locations:
city: Hadera
country: Israel
facility: Hillel Yaffe MC,
Study officials:
References: