Clinical trial NCT03341221: Diagnosis of Ascites in Infants and Children
Official title: Diagnosis of Ascites in Infants and Children
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Ascites
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-11-14
Enrollment: 50
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Infants and children with ascites aged from 1month to 18 year

Brief summary: Ascites is the pathologic accumulation of fluid within the peritoneal cavity. Causes of ascites in infants and children :hepatobiliary disorders,serositis, neoplasm, cardiac, genitourinary disorder, metabolic disease and others.

Diagnosis of ascites :history of abdominal distention, increasing weight, respiratory embarrassement, symptoms and signs of (hepatic ,cardiac,renal disease, tuberculosis and malignancy).

lnvestigation:complete blood count, complete urine examination, liver function tests, plasma proteins, renal function tests, clotting screen, tuberculin test, chest and abdominal plain films,abdominal ultrasound, upper gastrointestinal endoscopy, abdominal paracentesis for ascitic fluid analysis .

Detailed description: Definition : Ascites is the pathologic fluid accumulation within the peritoneal cavity .

causes of ascites in infants and children :

* Hepatobiliary disorders (cirrhosis, congenital hepatic fibrosis, acute hepatitis B,C ,Budd -chiari syndrome, Bile duct perforation)
* Serositis (crohn's disease, eosinophilic enteropathy , Henoch- Shonlein purpura )
* Neoplasm (lymphoma, wilm's tumor ,Glioma, Germ cell tumor, Ovarian tumor,mesothelioma, Neroblastoma )
* Cardiac (Heart failure )
* Metabolic disease
* Gastrointestinal disorder (Nephrotic syndrome, peritoneal dialysis ). Diagnosis of ascites :History of abdominal distention, increasing weight, respiratory embarrassement, jaundice, bleeding (haematemsis, melena, and epistaxis ),Pruritus ,Growth failure ,abdominal pain, fever,Cyanosis, ,dyspnea during suckling, Orthopnea, Buffy eyes, lower limb swelling, Haematrruria .

By examination : Tachycardia ,Tachypnea ,Hypertension ,cyanosis, jaundice, clubbing of fingers ,limb edema ,Hepatomegaly, splenomegaly, dilated abdominal wall veins.

Investigations :

Laboratory tests :complete blood count , complete urine examination, liver function tests, plasma proteins, renal function tests, clotting screen, tuberculin test.

Imaging studies :chest and abdominal plain films, abdominal ultrasound, upper gastrointestinal endoscopy CT, MR I, Abdominal paracentesis for ascitic fluid analysis :cell count / cytology ,Gram 'stain and culture, Total proteins (albumin /globulin ratio ), Glucose, Amylase, lactase dehydrogenase, Triglycerides,Bilirubin.

Serum ascites albumin gradient (SAAG )is the best single test for classification of ascites into portal hypertensive (SAAG \>1.1g/dl) and non-portal hypertensive (SAAG \<1.1g/dl) causes.

Eligibility criteria: Inclusion Criteria:

* age from 1month to 18 year
* infants and children with ascites (hepatic, cardiac, renal, malignant or tuberculous )
* infants and children with peritonitis

Exclusion Criteria:

* age \<1month
* surgical conditions as ruptured viscous or located abscess

Primary outcomes:
measure: Diagnosis of ascites in infants and children with hepatic, cardiac, renal disease, tuberculosis and malignancy
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
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