Clinical trial NCT04578964: Determining the Age of First Acute Coronary Syndrome
Official title: Determining the Cardiovascular Risk Factors Affecting the Age of First Acute Coronary Syndromes
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Coronary Syndrome
Age Problem
Risk Factor, Cardiovascular
Keywords: acute coronary syndrome
age
obesity
risk factor, Cardiovascular
smoking
gender
hyperlipidemia
diabetes mellitus
psychosocial stress
Lead sponsor: Antalya Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2020-10-08
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: First acute coronary syndrome patients admitted to the coronary intensive care unit

Brief summary: The study aimed to evaluate the association between the obesity grade and the age of the first acute coronary syndrome (ACS). The effect of cardiovascular (CV) risk factors and the age of first ACS in patients with severe obesity was also examined. Consecutive patients with diagnosis of first episode of ACS were prospectively enrolled in 2014 to 2024.Cardiovascular risks of patients will be determined according to clinical and laboratory evaluation and patients were categorized by their body mass indices (BMI). Independent variables that effected the age of first ACS were examined by linear regression analysis

Detailed description: In the first stage, the first ACS diagnosis of the patients will be tried to be clarified. It will be tried to clarify whether the patients have had ACS before, according to their history, ecg echo and coronary angiography findings. Patients with previous ACS or uncertain ACS diagnosis will not be included in the study.

In the second stage, cardiovascular risk burdens of patients for whom the initial ACS diagnosis is clear will be revealed. Smoking, diabetes mellitus (DM), hypertension (HT), psychological stress, socio-economic status, migration history, cholesterol parameters will be determined. The duration and severity of these risk factors will be determined. In the final model, each risk factor will be examined in detail with its sub-tabs and the effect of each risk factor will be examined separately.

Eventually, a model will be developed that allows predicting the first ACS age. The shortcomings of this model and the narrow scope of the definition of the population will be determined and the direction will be determined for the studies that improve these points.

Eligibility criteria: Inclusion Criteria:

* Adult patients with the diagnosis of the first acute coronary syndrome

Exclusion Criteria:

* Previous cardiovascular disease
* Chronic renal disease,
* Chronic obstructive pulmonary disease,
* Malignancy,
* Regularly use of statins, antiplatelets or anticoagulants,
* Situations where oral communication cannot be established with the patient
* Situations when coronary angiography (CAG) could not be performed .
* Patients with findings that might be related to previous MI on electrocardiography (ECG) or echocardiography and total occlusion other than 'culprit' lesion and no critical stenosis on CAG

Primary outcomes:
measure: Determining the effect of cardiovascular risk factors on the mean age of the first acute coronary syndrome
timeFrame: 10 years
Secondary outcomes:
measure: Determining the effect of obesity on the mean age of the first acute coronary syndrome
timeFrame: 6 years
measure: Determining the effect of migration on the mean age of the first acute coronary syndrome.
timeFrame: 6 years
measure: Model for calculating the acute coronary syndrome age
timeFrame: 8 years
Other outcomes:
Locations:
city: Antalya
country: Turkey
facility: Deniz Demirci
Study officials:
References:
citation: Demirci D, Demirci DE, Chi G. Association between obesity grade and the age of the first acute coronary syndrome: Prospective observational study. Int J Cardiol. 2022 Mar 15;351:93-99. doi: 10.1016/j.ijcard.2021.11.080. Epub 2021 Dec 2.