louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05479643: A Personalized Voice Restoration Device for Patients With Laryngectomy
Official title: A Pilot Study for a Novel and Personalized Voice Restoration Device for Patients With Laryngectomy
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Dysphonia
Aphonia
Lead sponsor: Weill Medical College of Cornell University
Sponsor class: OTHER
First posted: 2022-07-29
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 110
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The investigators will conduct a pilot experiment for a novel and personalized method for voice restoration using machine learning applied to surface EMG (sEMG) signal from articulatory muscles of the face and the neck allowing recognition of silent speech. The investigators predict that the use novel personalized method for voice restoration will be feasible and successful for patients.

Detailed description: This is a prospective pilot study evaluating the feasibility of a personalized voice restoration device and patients' experience with it. Study participation will include a one-time visit where subjects will read passages and phrases. Acoustic and signal data will be captured. Machine learning will be applied to the data to classify words. Subjects will also participate in a qualitative interview about their experience with voice restoration devices.

Eligibility criteria: Inclusion Criteria:

Group A: Healthy Volunteers

1. Adult subjects, 18 or older
2. Without any voice impairments

Group B: Subjects with Aphonia or Dysphonia

1. Adult subjects, 18 or older
2. Documentation of severe dysphonia and/or aphonia, or a GRBAS score \> 0 (GRBAS is a scale that can be used to assess voice quality of subjects who do not have a recorded history of dysphonia or aphonia. The GRBAS scale evaluates for grade, roughness, breathiness, asthenia, and strain).

Exclusion Criteria:

- Group A: Healthy Volunteers

1. Voice impairment

Group B: Subjects with Aphonia or Dysphonia

1. Subjects whose face muscles are entirely paralyzed

Primary outcomes:
measure: Percentage of Words and Numbers Correctly Identified
timeFrame: "During Procedure/use of Surface ElectroMyoGraphy"
measure: Subject experience with voice restoration devices: Qualitative
timeFrame: 10 minutes after the time of intervention
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Weill Cornell Medicine
state: New York
Study officials:
affiliation: Weill Medical College of Cornell University
name: Anais Rameau, M.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04460443: Sofosbuvir in Treatment of COVID 19
Official title: Sofosbuvir Based Regimens in Treatment of COVID 19 Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
PHASE3
Conditions: COVID
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2020-07-07
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Sofosbuvir containing treatment in treatment of COVID 19 Egyptian patients

Detailed description: Sofosbuvir containing treatment of COVID 19 Egyptian patients: a randomized-controlled trial

Eligibility criteria: Inclusion Criteria:

* Covid positive patients.

Exclusion Criteria:

* Contraindication to sofosbuvir or ribavirin.

Primary outcomes:
measure: Number of patients with response to treatment
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Sherief Abd-Elsalam
Study officials:
affiliation: Tanta University - Faculty of Medicine
name: Marwa Salama, Consultant
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04395443: The Impact Of Clinical Pharmacists Medication Reconciliation Upon Patients Admission To Reduce Medication Discrepancies.
Official title: A Comparative Prospective Interventional Study Shows The Impact Of The Clinical Pharmacists' Role In The Emergency Department In Medication Reconciliation Upon Patients' Admission To Reduce The Medication Discrepancies.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Medication Reconcilitation Upon Hospital Admission
Keywords: Medication reconcilitation
Medication discrepancies
Admission pharmacist
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2020-05-20
Enrollment: 161
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: It is a quazai one arm study shows the impact of the role of the clinical pharmacists through medication reconciliation to patients admitted to the emergency department .The main aim is to show if the pharmacists intervention is associated with establishing a complete drug history list than the list already presented in the patient file and taken by the physician .Then a description of the medication errors detected will be done .

Detailed description: It is a quazai one arm study in which the pre phase is the detection of the complete and accurate drug history list already presented in the patient file and taken by the physician and the post phase is the detection of the complete and accurate drug history list taken by the clinical pharmacists after medication reconciliation for the same patients.

medication reconciliation will be done as a full diseases and preadmission medications history will be taken from the patients or the family through interviews, revising previous prescriptions and hospital records.

* Preadmission medication history will include medications trade names, doses, frequency and route of administration and treatment duration and also will include the consumption of vitamins or herbs.
* The medication errors will be detected ,calculated and classified according to medication at transitions and clinical handoffs (MATCH) toolkit for medication reconciliation and NCC MERP index.

Eligibility criteria: Inclusion Criteria:

* Patients with one or more chronic disease / drug.

Exclusion Criteria:

- Patients who cannot communicate or have no family members.

Primary outcomes:
measure: the total number of complete and accurate drug history list detected in each phase.
timeFrame: 2 months
measure: Detect the number of medication discrepancies and the proportion of the prescriptions with one or more medication discrepancies
timeFrame: 2 months
measure: classification of medication discrepancies
timeFrame: 2 months
measure: the total number of complete medication history lists will be written in the patients profiles
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Alexandria Main University Hospital
Study officials:
References:
Clinical trial NCT04366843: Impact of Exercises and Chair Massage on Musculoskeletal Pain of Young Musicians
Official title: Impact of Exercises and Chair Massage on Musculoskeletal Pain of Young Musicians
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Musculoskeletal Pain
Keywords: musculoskeletal pain
playing related musculoskeletal disorders
physiotherapy
Lead sponsor: Józef Piłsudski University of Physical Education
Sponsor class: OTHER
First posted: 2020-04-29
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The study is tested the idea of two forms of musculoskeletal pain prophylaxis (chair massage and an original set of exercises) among musicians.

The hypothesis of the study was that massage and exercises could be helpful for musicians to avoid pain conected with playing musical instrument.


Eligibility criteria: Inclusion Criteria:

* playing a musical instrument for a minimum of 5 years
* age over 18 years

Exclusion Criteria:

* neurological and oncological diseases
* medical contraindication to undertake physical exercise
* contraindications to perform massage
* lack of consent for participation in the study

Primary outcomes:
measure: Changes in algometric measurements at 4 weeks
timeFrame: Change between Baseline and post-treatment after 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Warsaw
country: Poland
facility: Józef Piłsudski University of Physical Education in Warsaw
Study officials:
References:
Clinical trial NCT05882643: Deep Neuromuscular Blockade in Strabismus Surgery
Official title: The Effect of the Deep Neuromuscular Block on the Refraction and the Oculocardiac Reflex During Strabismus Surgery in Pediatric Patients - a Prospective Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Strabismus
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2023-05-31
Enrollment: 204
Sex: ALL
Minimum age (years): 3
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine if inducing a moderate or greater neuromuscular block (TOF count 0-3) when performing a neuromuscular block in pediatric patients aged 3 to 18 years undergoing strabismus surgery under general anesthesia can reduce the incidence of the oculocardiac reflex.


Eligibility criteria: Inclusion Criteria:

* Pediatric patients between the ages of 3 and 18 who are American Society of Anesthesiologists physical classification (ASA) I, II, or III scheduled for strabismus surgery under general anesthesia.

Exclusion Criteria:

* Patients with underlying cardiovascular disease
* Patients with preoperative electrocardiograms showing conduction disturbances
* Patients with neuromuscular disease
* Any other patient who, in the opinion of the investigator, is not a good candidate for the study.

Primary outcomes:
measure: The incidence of grade 2 or greater oculocardiac reflex (induced, during strabismus surgery)
timeFrame: During induced oculocardiac reflex test by ophthalmologists
Secondary outcomes:
measure: The incidence of grade 1 oculocardiac reflex (induced, during strabismus surgery)
timeFrame: During induced oculocardiac reflex test by ophthalmologists
measure: The incidence of grade 2 or greater oculocardiac reflex (during strabismus surgery)
timeFrame: During general anesthesia for strabismus surgery (within 2 hour)
measure: The incidence of grade 1 greater oculocardiac reflex (during strabismus surgery)
timeFrame: During general anesthesia for strabismus surgery (usually within 2 hour)
measure: Number of times Rescue IV Atropine has been used for oculocardiac reflex
timeFrame: During general anesthesia for strabismus surgery (within 2 hour)
measure: The incidence of hypotension
timeFrame: During general anesthesia for strabismus surgery (within 2 hour)
measure: Postoperative nausea/vomiting
timeFrame: From extubation to post-anesthesia care unit stay (within 1 hour)
measure: Results from a refraction test before strabismus surgery
timeFrame: Before strabismus surgery (within 12 month)
measure: Results from a refraction test at strabismus surgery
timeFrame: During general anesthesia for strabismus surgery (within 2 hour)
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References:
Clinical trial NCT03139643: Assessment of the Predictors and Moderators of Behavior Change
Official title: Assessment of the Predictors and Moderators of Behavior Change
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Lead sponsor: Boston University Charles River Campus
Sponsor class: OTHER
First posted: 2017-05-04
Enrollment: 230
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The current study aims to investigate two potential interventions (i.e., cognitive dissonance and action planning) for inducing behavior change for behaviors important to college students-studying and exercise. In addition, this study will investigate factors that may impact behavior change, such as psychological and neuropsychological variables, to better understand how to bridge the intention-behavior gap.


Eligibility criteria: Inclusion Criteria:

* Boston University Psychology 101 students at least 18 years of age
* Able to provide informed consent for the study
* Sufficient command of the English language
* Have experience using a computer and mouse

Exclusion Criteria:

* None

Primary outcomes:
measure: International Physical Activity Questionnaire
timeFrame: Change from baseline to 4 weeks
measure: Studying Questionnaire
timeFrame: Change from baseline to 4 weeks
Secondary outcomes:
measure: Distress Intolerance Index
timeFrame: Change from baseline to 4 weeks
measure: UPPS Impulsive Behavior Scale (UPPS)
timeFrame: Change from baseline to 4 weeks
measure: Penn State Worry Questionnaire (PSWQ)
timeFrame: Change from baseline to 4 weeks
measure: Self-Control Scale (SCS)
timeFrame: Change from baseline to 4 weeks
measure: Delay Discounting Questionnaire
timeFrame: Change from baseline to 4 weeks
measure: Pittsburgh Sleep Quality Index (PSQI)
timeFrame: Change from baseline to 4 weeks
measure: Center for Epidemiological Studies Depression Scale (CES-D)
timeFrame: Change from baseline to 4 weeks
measure: Beck Anxiety Inventory (BAI)
timeFrame: Change from baseline to 4 weeks
measure: Generalized Self-Efficacy Scale
timeFrame: Change from baseline to 4 weeks
Other outcomes:
Locations:
Study officials:
References:
citation: Patten EA, Kredlow MA, Szuhany KL, Keshishian AC, Otto MW. Catching As and Zs: poor sleep quality predicts failures to increase studying time. Sleep Health. 2020 Feb;6(1):15-18. doi: 10.1016/j.sleh.2019.09.001. Epub 2019 Oct 31.
Clinical trial NCT01180543: Acne Treatment With Active Oplon's Patches
Official title: Phase II- Acne Treatment With Active Patches Which Contains Azelaic Acid, Citric Acid,Salicylic Acid and 2% Ascorbic Acid
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Acne Vulgaris
Lead sponsor: Oplon-Pure Science Ltd.
Sponsor class: INDUSTRY
First posted: 2010-08-12
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to demonstrate the effect of short treatment with active OPLON patches on Acne.

Detailed description: Patients with Acne Vulgaris were treated overnight with active patches. Effect is observed at the end of the treatment and 24 hours later.

Eligibility criteria: Inclusion Criteria:

* Acne Vulgaris
* Over 18 years
* Signing informed consent

Exclusion Criteria:

* Active treatment of acne
* Change in hormonal therapy
* Antibiotic treatment in a week prior to the experiment
* Sensitive skin
* Pregnancy

Primary outcomes:
measure: Severity Score of lesion
timeFrame: Severity Score of lesion [Time Frame: 24 hours following patch removal]
Secondary outcomes:
measure: Severity Score of lesion
timeFrame: Severity Score of lesion [Time Frame: 12 hours with the patch]
Other outcomes:
Locations:
city: Natanya
country: Israel
facility: Dermatology Clinic
Study officials:
affiliation: Laniado Medical Center
name: Avner Shemer, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02939443: Prone-position CT for Diagnosing Inguinal Hernia
Official title: Diagnosis of Inguinal Hernia by Prone- vs. Supine-position Computed Tomography
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hernia, Inguinal
Lead sponsor: Nagareyama Central Hospital
Sponsor class: OTHER
First posted: 2016-10-20
Enrollment: 68
Sex: ALL
Minimum age (years): 20
Maximum age (years): 89
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Background: The aim of this study was to investigate the efficacy of prone-position computed tomography (CT) for detecting and classifying inguinal hernia relative to supine-position CT before laparoscopic inguinal hernia repair.

Materials and Methods: Sixty-eight patients who underwent laparoscopic transabdominal preperitoneal repair of inguinal hernia were enrolled in this prospective study. Patients diagnosed with inguinal hernia by physical examination underwent abdominal CT in the supine and prone positions for preoperative assessment. The anatomy of the right and left inguinal regions was confirmed during the surgery and compared with the preoperative CT findings.


Eligibility criteria: Inclusion Criteria:

* inguinal hernia

Exclusion Criteria:

* emergency surgery for incarcerated hernia
* femoral hernia
* recurrent inguinal hernia after laparoscopic inguinal hernia repair

Primary outcomes:
measure: The detection rate of inguinal hernia
timeFrame: two years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01135043: Simple Verbal Intervention for Adequately Collecting Sputum
Official title: The Impact of the Simple Verbal Intervention for Adequately Collecting Sputum and the Acceptable Specimen Based on Gram Stain, on the Results of Sputum Acid-fast Bacilli Smear Testing
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Suspicious for Pulmonary Tuberculosis
Keywords: acceptable sputum
AFB culture
pulmonary tuberculosis
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2010-06-02
Enrollment: 188
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: simple verbal intervention with figure of lung and upper respiratory tract will be helpful to adequately collecting sputum.

and in the acceptable specimen based on Gram stain, positivity for AFB stain and culture rate will be higher.

Detailed description: suspicious patients for pulmonary tuberculosis are randomized to control or education group. patients in education group will be educated with the brochure that contains figure of lung/upper respiratory tract and methods of collecting sputum.

Eligibility criteria: Inclusion Criteria:

* age \> 18 years
* 2009.7\~2010.7 patients with suspicious pulmonary tuberculosis who visited Boramae Hospital

Exclusion Criteria:

* on medication for tuberculosis
* patients who medicated with fluoroquinolone within 1month
* patients without consciousness or patients who cannot expectorate sputum
* hemoptysis over 50cc per day
* patients who don't consent on the study

Primary outcomes:
measure: culture result of Mycobacteria in sputum
timeFrame: 8wk after AFB culture
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center
Study officials:
affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center
name: Chang-Hoon Lee, MD
role: STUDY_CHAIR
References:
citation: Lee YJ, Shin S, Roh EY, Yoon JH, Kim DK, Chung HS, Lee CH. The effectiveness of a brochure describing an acceptable method of sputum collection for tuberculosis testing. Int J Tuberc Lung Dis. 2013 Dec;17(12):1587-9. doi: 10.5588/ijtld.13.0336.
Clinical trial NCT03177343: Pristinamycin in the Treatment of MSSA Bone and Joint Infection
Official title: Pristinamycin in the Treatment of MSSA Bone and Joint Infection
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Methicillin Susceptible Staphylococcus Aureus (MSSA) Infection
Bone and Joint Infection
Keywords: Pristinamycin
Staphylococcus aureus
Bone and joint infection
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2017-06-06
Enrollment: 102
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients receiving pristinamycin as a part of treatment for an MSSA BJI and followed up between 2001 and 2011 in the infectious diseases department of HCL

Brief summary: Staphylococcus aureus represents the leading pathogen implicated in bone and joint infection (BJI), usually requiring prolonged combination antimicrobial therapy, which may be particularly challenging in the case of MDR bacteria and/or for patients with multiple drug intolerance. In the absence of new well-tolerated oral antistaphylococcal drugs, older antibiotics must be considered, such as the pristinamycin.

However, pristinamycin is not currently licensed for treatment of staphylococcal BJI and lack of clinical data prevents it from being considered as a reliable alternative therapeutic option in current guidelines.

The aim of this study is to evaluate pristinamycin (efficacy and tolerance) in the treatment of MSSA bone and joint infection (BJI).


Eligibility criteria: * Inclusion Criteria:
* All patients receiving pristinamycin as a part of treatment for an MSSA BJI and followed up between 2001 and 2011 in the infectious diseases department of Hospices Civils de Lyon (HCL)
* Exclusion Criteria:
* Patients with BJI related to diabetic foot or decubitus ulcer

Primary outcomes:
measure: Efficacy of pristinamycin in MSSA bone and joint infection
timeFrame: 80 weeks
Secondary outcomes:
measure: Tolerance of pristinamycin in MSSA bone and joint infection
timeFrame: 45 weeks
Other outcomes:
Locations:
city: Lyon
country: France
facility: Hospices Civils de Lyon - Hopital de la Croix Rousse - Centre de reference des infection ostéo-articulaires de Lyon
Study officials:
References:
Clinical trial NCT00225043: A Randomized, Double-Blind, Trial Comparing Epinephrine Versus Phenylephrine as a Vasoconstrictor in Regional Anesthesia for Upper Extremity Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: New York Presbyterian Brooklyn Methodist Hospital
Sponsor class: OTHER
First posted: 2005-09-23
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: The study involves research, the purpose of which is to compare three different drug mixtures (Epinephrine, Phenylephrine 25 µg, or Phenylephrine 50 µg). Specifically, how long each medicine lasts will be studied.


Eligibility criteria: Inclusion Criteria:

* Shoulder surgery with regional anesthesia

Exclusion Criteria:

* Shoulder surgery with general anesthesia unhealthy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Brooklyn
country: United States
facility: New York Methodist Hospital
state: New York
Study officials:
affiliation: New York Presbyterian Brooklyn Methodist Hospital
name: Joel Yarmush, MD, MPA
role: PRINCIPAL_INVESTIGATOR
References: