Clinical trial NCT01107223: Long Term Effect of General Practitioner Education on Antibiotic Prescribing
Official title: Long Term Effect of General Practitioner Education on Antibiotic Prescribing: a Large Scale Randomized Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Respiratory Tract Infections
Keywords: Antibiotic
Prescribing behaviour
Guidelines
Respiratory tract infections
Non-antibiotic prescription
Lead sponsor: Henri Mondor University Hospital
Sponsor class: OTHER
First posted: 2010-04-20
Enrollment: 170
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Respiratory tract infections are the most common indication for antibiotic prescribing in primary care. Several studies have shown a strong relationship between antibiotic use and bacterial resistance. The aim of this trial was to assess the long-term effect of a continuous education program on general practitioners antibiotic prescribing behaviour. 170 physicians were included in this study. Physicians randomized in the education group attended a two days seminar focused on evidence-based guidelines on antibiotic use in respiratory tract infections. The intervention was limited at physicians level and did not target the patients.


Eligibility criteria: Inclusion Criteria:

* General practitioners practicing in three departments of the Parisian area in France
* General practitioners attending a two days didactic educational meeting on evidence-based guidelines for diagnosis and treatment of acute respiratory tract infection.

Exclusion Criteria:

* None

Primary outcomes:
measure: Change in the percentage of prescriptions containing an antibiotic between control and intervention groups (seminar on the treatment of respiratory tract infections).
timeFrame: Effect of the intervention 4 to 6 months after the educational training.
measure: Change in the cost of antibiotic prescription between control and intervention groups (seminar on the treatment of respiratory tract infections).
timeFrame: Effect of the intervention 4 to 6 months after the educational training.
Secondary outcomes:
measure: Long term antibiotic prescription rates
timeFrame: Effect of the intervention 28 to 30 months after the educational training.
measure: Long term antibiotic cost.
timeFrame: Effect of the intervention 28 to 30 months after the educational training.
measure: Symptomatic drug prescription rates
timeFrame: Effect of the intervention 28 to 30 months after the educational training.
measure: Symptomatic drug cost.
timeFrame: Effect of the intervention 28 to 30 months after the educational training.
measure: Effect of patient age.
timeFrame: Effect of the intervention 28 to 30 months after the educational training.
measure: Effect of a seminar on problem-solving strategy on prescriptions.
timeFrame: Effect of the intervention 28 to 30 months after the educational training.
Other outcomes:
Locations:
city: Créteil
country: France
facility: Henri Mondor Hospital, department of general practice
Study officials:
affiliation: Henri Mondor University Hospital
name: Clause Attali, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ferrat E, Le Breton J, Guery E, Adeline F, Audureau E, Montagne O, Roudot-Thoraval F, Attali C, Le Corvoisier P, Renard V. Effects 4.5 years after an interactive GP educational seminar on antibiotic therapy for respiratory tract infections: a randomized controlled trial. Fam Pract. 2016 Apr;33(2):192-9. doi: 10.1093/fampra/cmv107. Epub 2016 Jan 21.