Clinical trial NCT05609864: Drug Wastage : Observational Study in the Operating Rooms of France
Official title: Drug Wastage : Observational Study in the Operating Rooms of France
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Drug Use
Keywords: Drug wastage
Green Anesthesia
Environmental sustainability
Injectable drugs
Eco-design of care
Operating Room
Lead sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Sponsor class: OTHER
Collaborators: name: Sainte-Anne Military Teaching Hospital
First posted: 2022-11-08
Enrollment: 3763
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients who will need an anesthesia act in operating room during a 24 hours period

Brief summary: Environmental awareness is leading medical field to question its responsibility and possibilities for action.

Drug residues can have a major environmental impact as per their bioaccumulation, toxicity and persistence characteristics, depending on where they are discarded. In France, drug residues should be disposed of by incineration, but in practice this is not systematic. Moreover, data on drug wastage in the operating rooms by anesthesia department are rare.

The GAME-OvBLOC observational study aim to evaluate drug wastage in the operating rooms by anesthesia department in France and to propose ways of improving health care practices.

Detailed description: Observational study with data collection over a 24-hour business day. Data collected refer to healthcare team's practices and patients.

Eligibility criteria: Inclusion Criteria:

* All patients who will need an anesthesia act in operating room during a 24 hours period

Exclusion Criteria:

* Patient opposition to participate in the study or parents opposition if the patient is a child or patient family opposition if the patient is not capable of being informed

Primary outcomes:
measure: Ratio of overall wastage in milliliter (mL) of prepared and discarded injectable drugs, to overall volume in milliliter (mL) of prepared injectable drugs
timeFrame: 24 hours
Secondary outcomes:
measure: Reason for discarding drug residues
timeFrame: 24 hours
measure: Describe drug wastage for each kind of surgery/anesthesia
timeFrame: 24 hours
measure: Drug residues discarding process
timeFrame: 24 hours
measure: Cost of overall injectable drugs wastage
timeFrame: 24 hours
measure: Describe drug wastage for each age group
timeFrame: 24 hours
measure: Describe waste and environmental impact of used plastic syringes
timeFrame: 24 hours
measure: Use of alternative to injectable drugs
timeFrame: 24 hours
Other outcomes:
Locations:
city: Cannes
country: France
facility: Centre Hospitalier de Cannes
state: Alpes-Maritimes
city: Charleville-Mézières
country: France
facility: Centre Hospitalier de Charleville-Mézières
state: Ardennes
city: Rodez
country: France
facility: Centre Hospitalier Jacques Puel
state: Aveyron
city: Strasbourg
country: France
facility: CHU de Strasbourg - IHU
state: Bas-Rhin
city: Marseille
country: France
facility: Hôpital La Timone (AP-HM)
state: Bouches-du-Rhône
city: Marseille
country: France
facility: Hôpital Nord (AP-HM)
state: Bouches-du-Rhône
city: Caen
country: France
facility: CHU de Caen
state: Calvados
city: Aurillac
country: France
facility: Centre Hospitalier Henri Mondor
state: Cantal
city: La Rochelle
country: France
facility: Groupe Hospitalier Littoral Atlantique
state: Charente-Maritime
city: Brive-la-Gaillarde
country: France
facility: Centre Hospitalier de Brive-la-Gaillarde
state: Corrèze
city: Dijon
country: France
facility: CHU de Dijon
state: Côte d'Or
city: Besançon
country: France
facility: CHU Jean Minjoz
state: Doubs
city: Valence
country: France
facility: Centre Hospitalier de Valence
state: Drôme
city: Corbeil-Essonnes
country: France
facility: Centre hospitalier Sud Francilien
state: Essonne
city: Brest
country: France
facility: HIA Clermont Tonnerre
state: Finistère
city: Brest
country: France
facility: CHRU de Brest
state: Finistère
city: Quimper
country: France
facility: Centre Hospitalier de Cornouailles
state: Finistère
city: Nîmes
country: France
facility: CHU de Nîmes
state: Gard
city: Bordeaux
country: France
facility: CHU de Bordeaux - Groupe hospitalier Pellegrin
state: Gironde
city: La Teste-de-Buch
country: France
facility: Centre Hospitalier d'Arcachon
state: Gironde
city: Pessac
country: France
facility: CHU de Bordeaux, Groupe Sud
state: Gironde
city: Pessac
country: France
facility: Clinique mutualiste de Pessac
state: Gironde
city: Limoges
country: France
facility: CHU de Limoges
state: Haute Vienne
city: Cornebarrieu
country: France
facility: Clinique des Cèdres
state: Haute-Garonne
city: Quint-Fonsegrives
country: France
facility: Clinique la Croix du Sud
state: Haute-Garonne
city: Saint-Jean
country: France
facility: Clinique de l'Union
state: Haute-Garonne
city: Toulouse
country: France
facility: CHU de Toulouse - Hôpital Rangueil
state: Haute-Garonne
city: Le Puy-en-Velay
country: France
facility: Centre Hospitalier Emile Roux
state: Haute-Loire
city: Clamart
country: France
facility: HIA Percy Clamart
state: Hauts-de-Seine
city: Le Plessis-Robinson
country: France
facility: Hôpital Marie Lannelongue
state: Hauts-de-Seine
city: Rennes
country: France
facility: CHU de Rennes - Pontchaillou
state: Ille-et-Vilaine
city: Rennes
country: France
facility: CHU de Rennes - Hôpital Sud
state: Ille-et-Vilaine
city: Rennes
country: France
facility: Clinique mutualiste La Sagesse
state: Ille-et-Vilaine
city: Grenoble
country: France
facility: CHU de Grenoble
state: Isère
city: Saint Denis
country: France
facility: CHU de la Réunion
state: La Réunion
city: Dax
country: France
facility: Centre Hospitalier de Dax
state: Landes
city: Amilly
country: France
facility: Centre Hospitalier de l'Agglomération Montargoise
state: Loiret
city: Olivet
country: France
facility: Clinique de l'Archette
state: Loiret
city: Angers
country: France
facility: CHU d'Angers
state: Maine-et-Loire
city: Reims
country: France
facility: Institut Godinot
state: Marne
city: Vandoeuvre les nancy
country: France
facility: Institut de Cancérologie de Lorraine
state: Meurthe-et-Moselle
city: Lorient
country: France
facility: Groupe Hospitalier Bretagne Sud
state: Morbihan
city: Lille
country: France
facility: Centre Oscar Lambret
state: Nord
city: Lille
country: France
facility: CHU de Lille - Institut coeur poumon
state: Nord
city: Lille
country: France
facility: CHU de Lille - Hôpital Huriez
state: Nord
city: Lille
country: France
facility: CHU de Lille - Hôpital Jeanne de Flandre
state: Nord
city: Lille
country: France
facility: CHU de Lille - Hôpital Roger Salengro
state: Nord
city: Arras
country: France
facility: Hôpital privé Arras les Bonnettes
state: Pas-de-Calais
city: Lens
country: France
facility: Centre Hospitalier de Lens
state: Pas-de-Calais
city: Clermont-Ferrand
country: France
facility: CHU de Clermont-Ferrand
state: Puy-de-Dôme
city: Clermont-Ferrand
country: France
facility: Clinique de la Plaine Santé
state: Puy-de-Dôme
city: Biarritz
country: France
facility: Clinique Aguilera
state: Pyrénées-Atlantiques
city: Pau
country: France
facility: Centre Hospitalier de Pau
state: Pyrénées-Atlantiques
city: Bron
country: France
facility: Hôpital mère-enfant (HCL)
state: Rhône
city: Lyon
country: France
facility: Hôpital Edouard Herriot
state: Rhône
city: Lyon
country: France
facility: Centre Léon Bérard
state: Rhône
city: Lyon
country: France
facility: Clinique de la Sauvegarde
state: Rhône
city: Rouen
country: France
facility: CHU de Rouen
state: Seine-Maritime
city: Amiens
country: France
facility: CHU d'Amiens
state: Somme
city: Amiens
country: France
facility: Clinique Victor Pauchet
state: Somme
city: Castres
country: France
facility: Centre Hospitalier Intercommunal Castres-Mazamet
state: Tarn
city: Trévenans
country: France
facility: Hôpital Nord Franche-Comté
state: Territoire De Belfort
city: Beaumont-sur-Oise
country: France
facility: Hôpital NOVO - Site de Beaumont-sur-Oise
state: Val d'Oise
city: Beaumont
country: France
facility: Hôpital Privé de la Chataigneraie
state: Val d'Oise
city: Cergy-Pontoise
country: France
facility: Hôpital NOVO - Site de Pontoise
state: Val d'Oise
city: Villejuif
country: France
facility: Institut Gustave Roussy
state: Val-de-Marne
city: Villeneuve-Saint-Georges
country: France
facility: Centre Hospitalier Intercommunal de Villeneuve Saint Georges
state: Val-de-Marne
city: Toulon
country: France
facility: Sainte-Anne Military Teaching Hospital
state: Var
city: Toulon
country: France
facility: Centre Hospitalier Intercommunal Toulon - La Seyne sur Mer
state: Var
city: Vantoux
country: France
facility: Hôpital Robert Schuman-Groupe UNEOS
state: Vaucluse
city: La Roche-sur-Yon
country: France
facility: Centre Hospitalier Départemental de Vendée
state: Vendée
city: Paris
country: France
facility: Hôpital Lariboisière (AP-HP)
city: Paris
country: France
facility: Hôpital Saint Louis (AP-HP)
city: Paris
country: France
facility: Hôpital Trousseau (AP-HP)
city: Paris
country: France
facility: Hôpital La Pitié-Salpêtrière
city: Paris
country: France
facility: Hôpital Européen Georges Pompidou
city: Paris
country: France
facility: Groupe Hospitalier Diaconesses Croix Saint Simon
city: Paris
country: France
facility: Hôpital Tenon (AP-HP)
city: Paris
country: France
facility: Institut mutualiste Montsouris
city: Villejuif
country: France
facility: Hôpital Paul Brousse (AP-HP)
city: Pointe-à-Pitre
country: Guadeloupe
facility: CHU de Guadeloupe
city: Mamoudzou
country: Mayotte
facility: Centre Hospitalier de Mayotte
city: Monaco
country: Monaco
facility: Centre Hospitalier Princesse Grace
Study officials:
affiliation: Sainte-Anne Military Teaching Hospital (Hôpital d'instruction des armées Sainte Anne)
name: Erwan D'Aranda, MD
role: STUDY_DIRECTOR
References:
citation: McGain F, Muret J, Lawson C, Sherman JD. Environmental sustainability in anaesthesia and critical care. Br J Anaesth. 2020 Nov;125(5):680-692. doi: 10.1016/j.bja.2020.06.055. Epub 2020 Aug 12.
citation: Barbariol F, Deana C, Lucchese F, Cataldi G, Bassi F, Bove T, Vetrugno L, De Monte A. Evaluation of Drug Wastage in the Operating Rooms and Intensive Care Units of a Regional Health Service. Anesth Analg. 2021 May 1;132(5):1450-1456. doi: 10.1213/ANE.0000000000005457.
citation: Mankes RF. Propofol wastage in anesthesia. Anesth Analg. 2012 May;114(5):1091-2. doi: 10.1213/ANE.0b013e31824ea491. Epub 2012 Mar 13.
citation: Ramstrom H, Martini S, Borgendahl J, Agerstrand M, Larfars G, Ovesjo ML. Pharmaceuticals and Environment: a web-based decision support for considering environmental aspects of medicines in use. Eur J Clin Pharmacol. 2020 Aug;76(8):1151-1160. doi: 10.1007/s00228-020-02885-1. Epub 2020 May 9.