Clinical trial NCT03055546: Effects of Intranasal Oxytocin on Emotion Regulation
Official title: Effects of Intranasal Oxytocin on Emotion Regulation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: Healthy
Keywords: oxytocin
emotion regulation
Lead sponsor: University of Electronic Science and Technology of China
Sponsor class: OTHER
First posted: 2017-02-16
Enrollment: 80
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The aim is to examine whether intranasal oxytocin will influence the individuals' emotion regulation ability and related neural mechanisms.

Detailed description: In the present study, the investigators plan to conduct a between-subject, double-blind, placebo-controlled experiment to investigate the effects of oxytocin on neural, physiological and behavior activity related to emotion regulation. The emotion regulation ability will be assessed by emotional go-nogo task and cognitive reappraisal task. The neural activity will be explored by functional magnetic resonance imaging (fMRI). And the investigators will record participants' heart rate during fMRI to investigate the effects of oxytocin on heart rate variability in emotion regulation process.

All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration, including Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS), Autism Spectrum Quotient (ASQ), Empathy Quotient (EQ), Interpersonal Reactivity Index (IRI), Action Control Scale (ACS), Emotion Regulation Questionnaire (ERQ), Berkley Expressivity Questionnaire (BEQ), and so on.

Eligibility criteria: Inclusion Criteria:

* healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria:

* history of head injury;
* claustrophobia;
* medical or psychiatric illness.

Primary outcomes:
measure: Oxytocin effects on neural activity during emotion regulation task
timeFrame: Between 45-110 minutes after the intranasal administration of oxytocin
Secondary outcomes:
measure: Oxytocin effects on heart rate variability during emotion regulation task
timeFrame: Between 45-110 minutes after the intranasal administration of oxytocin
measure: Oxytocin effects on behavior response during emotion regulation task
timeFrame: Between 45-110 minutes after the intranasal administration of oxytocin
measure: Oxytocin effects on heart rate variability during resting-state
timeFrame: Between 35-45 minutes after the intranasal administration of oxytocin
measure: Oxytocin effects on neural activity during resting-state
timeFrame: Between 35-45 minutes after the intranasal administration of oxytocin
Other outcomes:
Locations:
city: Chengdu
country: China
facility: School of Life Science and Technology, University of Electronic Science and Technology
state: Sichuan
Study officials:
affiliation: University of Electronic Science and Technology of China
name: Keith Kendrick, Dr.
role: STUDY_DIRECTOR
affiliation: University of Electronic Science and Technology of China
name: Benjamin Becker
role: PRINCIPAL_INVESTIGATOR
References: