louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01022502: Comparison of Refined and Crude Indigo Naturalis Ointment in Treating Psoriasis
Official title: Efficacy and Safety Comparison Between Refined and Crude Indigo Naturalis Ointment in the Treatment of Psoriatic Vulgaris
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Psoriasis Vulgaris
Keywords: psoriasis, indigo naturalis
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2009-12-01
Enrollment: 38
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To compare the efficacy and safety of refined indigo naturalis ointment with that of crude ointment in treating psoriasis.

Detailed description: Our previous studies have shown that topical application of indigo naturalis significantly improves psoriatic symptoms. However, patient compliance is hindered because the preparation is unsightly and stains clothing.

To improve patient compliance, we have developed a refined formulation in which closer to natural skin tones and less prone to stain clothing. In this study, we evaluated the efficacy and safety of this refined form of oil extract ointment and compared the results with those of the original crude form of indigo naturalis ointment in treating psoriasis.

Eligibility criteria: Inclusion Criteria:

* Patients were had received a diagnosis of plaque psoriasis based on clinical assessment by two dermatologists at least a one year prior to entry into the study;
* Patients had mild to moderate plaque psoriasis with bilateral symmetric lesions; were adults aged 20 to 65 years;
* Patients were in good general health.
* Female patients of childbearing age agreed to continue using birth control measures for the duration of the study.

Exclusion Criteria:

* Patients had non-plaque (i.e., pustular, guttate, or erythrodermic) or drug-induced forms of psoriasis; total body surface involvement of more than 60%;
* Patients had a history of allergy to indigo naturalis.
* Patients were excluded if they have received systemic therapy within 4 weeks before enrollment, phototherapy within 3 weeks, or used topical psoriasis agents within 2 weeks before enrollment.
* Patients had included usage of medications that affect psoriasis during the study and unwillingness to comply with study protocol.

Primary outcomes:
measure: Change From Baseline in Psoriasis Severity Idex(PSI) at Week 8.
timeFrame: Baseline and Week 8
measure: Clearing Percentage of Target Plaque Area
timeFrame: Baseline and Week 8
measure: Percentage Improvement Compared to Baseline in the Target Plaque.
timeFrame: Baseline and Week 8
Secondary outcomes:
measure: Patients' Rating of the Overall Improvement at Week 8
timeFrame: Baseline and Week 8
measure: Patients Preferred Ointment Type.
timeFrame: Week 8
Other outcomes:
Locations:
city: Keelung
country: Taiwan
facility: Chang Gung Memorial Hospital
Study officials:
affiliation: Chang Gung Memorial Hospital
name: Yin-Ku Lin, MD. PhD.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02700802: Mitigating Hunger and Food Insecurity Among Socioeconomically Disadvantaged Caregivers of Hospitalized Children
Official title: Mitigating Hunger and Food Insecurity Among Socioeconomically Disadvantaged Caregivers of Hospitalized Children
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Health Behavior
Keywords: food insecurity
informal caregiver health
clinic-to-community linkages
community resources
Lead sponsor: University of Chicago
Sponsor class: OTHER
First posted: 2016-03-07
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The Feed1st proposed program of research will promote health of informal caregivers with a hospitalized child by testing a self-management intervention that addresses the widely overlooked problem of caregiver hunger. As many as 54% of parents and other informal caregivers of hospitalized children struggle with insufficient food to nourish themselves and their family during and after a hospital stay. Hunger impairs caregiver physical and mental health by depleting energy for self-care, emotional self-regulation, and supportive interactions with the child, the family, and the formal caregiver team. The long-term objective of the Feed1st program is to alleviate hunger and food insecurity among families with hospitalized children. Established in partnership with nursing and chaplaincy leadership at our children's hospital and the Greater Chicago Food Depository, the Feed1st program currently operates self-serve food pantries on four inpatient units and the emergency department in our children's hospital on Chicago's South Side. Since 2010, Feed1st has provided nearly 8500 pounds of food to at least 4,000 individuals and 1500 households via the self-serve food pantries in the children's hospital. Over this same period, our team has also created a system for efficiently connecting families to community-based resources for hunger and other basic needs.


Eligibility criteria: Inclusion Criteria:

- 18 years of age or older and English speaking, the primary caregiver to a dependent child younger than age 18, have been screened for household food insecurity, reside in the 16 zip code primary service area geography,

Exclusion Criteria:

* Caregivers of children in the neonatal intensive care unit (NICU) will be excluded to minimize infectious risk to critically ill newborns and their caregivers.

Primary outcomes:
measure: Change from baseline in mental health-related quality of life at 6 months
timeFrame: Baseline, 4-7 days, 3 months, and 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of Chicago
name: Stacy T Lindau, MD, MAPP
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05039502: Releasing of Inflammatory Mediators During Retreatment of Root Canals
Official title: The Effect of Different File Systems Used in Retreatment on the Release of Inflammatory Mediators
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Inflammatory Response
Root Canal Infection
Lead sponsor: Bulent Ecevit University
Sponsor class: OTHER
First posted: 2021-09-09
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Maximum age (years): 68
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region

Detailed description: Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.

Eligibility criteria: Inclusion Criteria:

* Patients who had single root canal treated teeth with chronic periapical lesion

Exclusion Criteria:

* Patients who are immunocompromised
* Patients under antibiotic or analgesic medication

Primary outcomes:
measure: change of inflammatory mediator level
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Zonguldak
country: Turkey
facility: Faculty of Dentistry of Bulent Ecevit University
Study officials:
affiliation: Bulent Ecevit University
name: Sevinç Aktemur Türker
role: STUDY_DIRECTOR
References:
Clinical trial NCT02891902: Impact of Dedicated Hygienist Staff on the Occurrence of Intensive Care Unit -Aquired Bloodstream Infections
Official title: Impact of Dedicated Hygienist Staff on the Occurrence of Intensive Care Unit -Aquired Bloodstream Infections
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intensive Care Unit -Aquired Bloodstream Infections.
Lead sponsor: Assistance Publique Hopitaux De Marseille
Sponsor class: OTHER
First posted: 2016-09-08
Enrollment: 4000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients admitted to reanimation department

Brief summary: The purpose of this study is to evaluate in a multicentric cluster randomized study the effect of the presence of dedicated nurses for training of ICU staff in preventing nosocomial infections. The rate of bloodstream infections per 100 admitted patients is used as the main endpoint. A sample of 4000 included patients in the 6 participating ICU is included with the objective to show a reduction of one third of the rate of ICU-acquired bloodstream infections. The study is currently at the end of the recrutimeent phase.

Detailed description: 15% of patients admitted to intensive care have an infection acquired in the service, including bacteremia is a serious form. Compliance with hygiene measures and recommendations in the use of invasive devices can reduce the incidence. The advantage of simple recommendations type "bundle" could, however, be insufficient because not associated with training and monitoring compliance with the recommendations. The aim of this study is to show that the daily intervention of a public health nurse on the basis of a half full-time equivalent, allows these actions and therefore a reduction in the bloodstream of the attack rate acquired in the ICU compared dissemination of simple recommendations.

Eligibility criteria: Inclusion Criteria:

* patients admitted to reanimation department

Exclusion Criteria:

* no exclusion criteria

Primary outcomes:
measure: rate of first ICU acquired bloodstream infection for 100 admitted patients
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Marseille
country: France
facility: Hopital Nord Assistance Publique Hôpitaux de Marseille
Study officials:
affiliation: Assistance Publique Hôpitaux de Marseille
name: Urielle DESALBRES
role: STUDY_DIRECTOR
References:
Clinical trial NCT05090202: Prediabetes and Newly Diagnosed Diabetes in Chronic Heart Failure
Official title: Prevalence of Prediabetes and Newly Diagnosed Diabetes in Patients With HFpEF( Heart Failure With Preserved Ejection Fraction) and HFrEF(Heart Failure With Reduced Ejection Fraction) in Sohag University Hospital
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Chronic Heart Failure
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2021-10-22
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients presented by heart failure NYHA class 2 or more and admitted to Sohag University hospital according to inclusion and exclusion criterea

Brief summary: The aim the study is to determine the prevalence of prediabetic dysglycemia and newly diagnosed diabetes among individuals with CHF(chronic heart failure) in sohag university hospital patients .

Detailed description: - Prospective study to:

1. study the differences in the prevalence of Prediabetes and newly diagnosed diabetes among the patients with HFrEF and HFpEF
2. The effect of dysglycemia on prognosis of patients with chronic heart failure.
3. The effect of early discover of diabetes mellitus on prognosis of patients with chronic heart failure

Eligibility criteria: Inclusion criteria:

* All patients presented by heart failure
* 18 years or older
* Classified according to NYHA " New York Heart Association" classification from NYHA class 2 and more

Exclusion Criteria:

* Overt diabetes
* Rheumatic Heart Disease
* Congenital heart disease

Primary outcomes:
measure: Heart failure hospitalization.
timeFrame: From date of randomization up to 1 month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Nielsen R, Jorsal A, Iversen P, Tolbod L, Bouchelouche K, Sorensen J, Harms HJ, Flyvbjerg A, Botker HE, Wiggers H. Heart failure patients with prediabetes and newly diagnosed diabetes display abnormalities in myocardial metabolism. J Nucl Cardiol. 2018 Feb;25(1):169-176. doi: 10.1007/s12350-016-0622-0. Epub 2016 Jul 29.
Clinical trial NCT04731402: The Effect of Acupressure, Laughter Yoga and Mindfulness on Menopausal Symptoms and Quality of Life
Official title: The Effect of Acupressure, Laughter Yoga and Conscious Awareness on Menopausal Symptoms and Quality of Life in Menopausal Women.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Menopausal Symptoms
Quality of Life
Lead sponsor: Inonu University
Sponsor class: OTHER
First posted: 2021-02-01
Enrollment: 180
Sex: FEMALE
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Intervention model description: randomized controlled trial
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aim of the study is to determine the effect of acupressure, laughter yoga and Mindfulness stress reduction program on menopausal symptoms and quality of life.Menopausal period, which is one of the life stages, causes physiological changes and can decrease the quality of life.

The research is a randomized controlled trial. 180 women who meet the conditions for research will be included in the study. Three instruments were used to obtain the research data: Personal Information Form,Menopausal Symptoms Rating Scale and Menopause-Specific Quality of Life Scale.

Detailed description: On average, one third of a woman's life passes during menopause. The menopausal period is an important period that brings many physical and psychological changes with it and significantly affects the disease process and the family and society. Cultural and ethnic characteristics of the society are among the important factors that affect women's attitudes towards menopause and the meaning of middle age for women.women seek ways to deal with menopausal symptoms.

women prefer drug-free coping methods. Mindfulness stress reduction program, yoga and laughter yoga are an alternative way to reduce menopausal symptoms.. These methods can reduce the complaints and increase the quality of life. For this reason, the effect should be determined in the menopausal period.

Eligibility criteria: Inclusion Criteria:

* in the menopausal period

Exclusion Criteria:

* presence of psychiatric illness using psychiatric medication

Primary outcomes:
measure: Acupressure, Laughter Yoga and mindfulness stress reduction program Effects on menopause symptoms
timeFrame: Up to 12 weeks
measure: Acupressure, Laughter Yoga and mindfulness stress reduction program Effects on menopausal quality of life
timeFrame: Up to 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Malatya
country: Turkey
facility: Hacer
state: Battalgazi
Study officials:
References:
Clinical trial NCT03350802: Procalcitonin Test for Differentiation of the Cause of Pneumonia
Official title: Usefulness of Procalcitonin Test to Differentiate the Cause of Pneumonia in Patients With Cancers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Procalcitonin
Pneumonia
Cancer
Lead sponsor: National Cancer Center, Korea
Sponsor class: OTHER_GOV
First posted: 2017-11-22
Enrollment: 649
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1. Patients who are suspected of acute pneumonia due to symptoms and imaging findings compatible with pneumonia can be enrolled in this cohort.

   * suspected symptom: cough, sputum, dyspnea or fever/chill
   * suspected image findings: consolidation or ground-glass opacity on chest radiograph or CT
2. All patients enrolled in this cohort undergo procalcitonin test in addition to basic microbiological test.

   * basic microbiological test: blood culture, sputum gram stain/culture, pneumococcal urinary antigen, legionella urinary antigen, mycoplasma antibody etc.

Brief summary: The purpose of this study is to evaluate the usefulness of procalcitonin test for differentiation of the cause of pneumonia in patients with cancer.

Detailed description: Serum procalcitonin test is currently used as the biomarker for bacterial infection. Especially, procalcitonin test has been reported to be helpful in differentiating bacterial pneumonia from viral pneumonia, acute exacerbations of interstitial pneumonitis or chronic obstructive lung disease. However, it is not known whether procalcitonin test can help distinguish bacterial pneumonia from non-bacterial pneumonia such as radiation pneumonitis or chemotherapy-induced pneumonitis in patients with cancer.

The aim of this prospective cohort study is to observe the clinical benefits of procalcitonin test for differentiation of the cause of pneumonia in patients with cancer.

Eligibility criteria: Inclusion Criteria:

* Age greater than 18 years
* Patients who have symptoms and suspected imaging findings compatible with pneumonia

Exclusion Criteria:

* Patients who have been treated with antibiotics or steroid therapy.

Primary outcomes:
measure: Procalcitonin level according to the cause of pneumonia in patients with cancer
timeFrame: procalcitonin level is checked within 24hours after visiting hospital
Secondary outcomes:
measure: Influence of neutropenia on procalcitonin level in patients with baterial pneumonia
timeFrame: procalcitonin level is checked within 24hours after visiting hospital
measure: procalcitonin level in patients with atypical pneumonia
timeFrame: procalcitonin level is checked within 24hours after visiting hospital
Other outcomes:
Locations:
city: Goyang-si
country: Korea, Republic of
facility: Respiratory Clinic, National Cancer Center
state: Gyeonggi-do
Study officials:
affiliation: National Cancer Center
name: HEE SEOK LEE, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00405002: A Validation Study of a New System for Measuring the End Expiratory Lung Volume During Mechanical Ventilation
Official title: A Validation Study of a New System for Measuring the End Expiratory Lung Volume During Mechanical Ventilation Acute in Intubated Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Respiratory Failure
Keywords: Acute respiratory failure
Lead sponsor: Policlinico Hospital
Sponsor class: OTHER
First posted: 2006-11-29
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: ALI/ARDS patients

Brief summary: In this study the investigators aim to evaluate a new system dedicated to estimate the end expiratory lung volume, by measuring the VO2-VCO2, during mechanical ventilation compared to the helium dilution technique and the computed tomography (CT) scan.

Detailed description: In this study we aimed to evaluate a new system dedicated to estimate the end expiratory lung volume, by measuring the VO2-VCO2, during mechanical ventilation compared to the Helium dilution technique and the CT scan. We will compare the data considering the CT scan data as the gold standard.

Eligibility criteria: Inclusion Criteria:

* Adult intubated subjects

Exclusion Criteria:

* Barotrauma

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Milano
country: Italy
facility: Policlinico Hospital
Study officials:
affiliation: Policlinico Hospital
name: Davide Chiumello, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chiumello D, Cressoni M, Chierichetti M, Tallarini F, Botticelli M, Berto V, Mietto C, Gattinoni L. Nitrogen washout/washin, helium dilution and computed tomography in the assessment of end expiratory lung volume. Crit Care. 2008;12(6):R150. doi: 10.1186/cc7139. Epub 2008 Dec 1.
Clinical trial NCT06819202: Effect of Hyperbaric Oxygen Therapy(HBOT) on Patients With Sudden Sensorineural Hearing Loss(SSNHL) and Coagulation Function
Official title: Effect of Hyperbaric Oxygen Therapy on Patients With Sudden Sensorineural Hearing Loss and Coagulation Function
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Sudden Sensorineural Hearing Loss (SSNHL)
Hyperbaric Oxygen Therapy
Lead sponsor: Shanghai University of Traditional Chinese Medicine
Sponsor class: OTHER
First posted: 2025-02-11
Enrollment: 1309
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: From January 2022 to September 2024, in Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Otolaryngology Hospital Affiliated to Fudan University, Xinhua Hospital affiliated to Shanghai Jiao Tong University or Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, treating patients with sudden sensorineural deafness.

Brief summary: The objective of this observational study was to understand the effect of HBO on patients with SSNHL and its association with coagulation function and prognosis.

The main question it aims to answer is whether HBO therapy can improve outcomes and coagulation function in patients with SSNHL.

The prognosis of SSNHL patients receiving HBO and SSNHL patients not receiving HBO were compared


Eligibility criteria: Inclusion Criteria:

* Meet the diagnostic criteria for sudden deafness in the American Academy of Otolaryngology Head and Neck Surgery 2019 Clinical Practice Guidelines for Sudden Deafness;
* Aged 18-75 years old;
* Patients with unilateral sudden deafness for the first time, and the onset time is less than 2 weeks.

Exclusion Criteria:

* Patients with other ear diseases, such as auditory trauma, barotrauma, retrocochlear disease, bilateral hearing loss, history of chronic otitis media in the same ear, and history of surgery in the same ear;
* Patients with serious primary diseases such as heart, liver, kidney dysfunction and hematopoietic system diseases;
* Pregnant and nursing patients;
* Accompanied by serious mental illness;
* Patients with incomplete clinical data.

Primary outcomes:
measure: Hearing recovery rate
timeFrame: From onset to 3 months after treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai University of Traditional Chinese Medicine
state: Putuo
Study officials:
References: