Clinical trial NCT01511679: Brain-imaging and Adolescent Neuroscience Consortium
Official title: Brain-imaging and Adolescent Neuroscience Consortium
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Alcohol Abuse
Keywords: Alcohol abuse
Lead sponsor: Boston Children's Hospital
Sponsor class: OTHER
Collaborators: name: Massachusetts General Hospital
name: Mclean Hospital
name: Massachusetts Institute of Technology
First posted: 2012-01-19
Enrollment: 0
Sex: ALL
Minimum age (years): 12
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male and female adolescents 12-21 years-of-age presenting for care at one of the participating medical clinics

Brief summary: This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.

Detailed description: The overall specific aims of this study are to: 1) assess the short and long-term consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development during preadolescence and adolescence; 2) determine the effects of timing, dose, and duration of alcohol on brain and cognitive development; 3) assess recovery of neural and behavioral function to determine if the plasticity of the adolescent brain makes it more or less vulnerable to alcohol's acute and chronic effects; 4) understand how other key covariates (e.g., existing or emerging psychopathology, family history of alcoholism, demographics, pubertal development) factor into alcohol's effects on the brain; and 5) identify early neural, cognitive, and affective markers that may predict alcohol abuse and dependence during adolescence and/or adulthood.

Eligibility criteria: Inclusion Criteria:

* able to read and understand English
* available for follow-up
* parental consent/adolescent assent for those 12-17 years
* consent for those 18-21 years

Exclusion Criteria:

* Weight \> 300 lbs
* braces or unremovable embedded metal
* claustrophobia or inability to lie still in MRI machine
* current or past 12-mos pregnancy (females)
* requires urgent medical/mental health care

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Belmont
country: United States
facility: McLean Hospital
state: Massachusetts
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Boston
country: United States
facility: Boston University School of Medicine
state: Massachusetts
city: Cambridge
country: United States
facility: Massachusetts Institute of Technology
state: Massachusetts
Study officials:
affiliation: Boston Children's Hospital
name: John R Knight, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Massachusetts General Hospital
name: Gordon J Harris, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Boston Children's Hospital
name: Simon Warfield, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Harvard University
name: Avram Holmes, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Mclean Hospital
name: Scott Lukas, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Mclean Hospital
name: Marisa Silveri, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Boston University
name: Marlene Oscar Berman, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Massachusetts Institute of Technology
name: John Gabrieli, PhD
role: PRINCIPAL_INVESTIGATOR
References: