Clinical trial NCT04731584: Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion
Official title: Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stroke
Systemic Infection
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2021-02-01
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients hospitalized for TM after a proximal ischemic stroke of the middle cerebral artery and whose reperfusion is satisfactory (TICI 2b, 2c and 3).

Population of control patients, consisting of patients admitted on an outpatient basis for diagnostic cerebral arteriography.

Brief summary: Strokes management, secondary to proximal arterial occlusion, by endovascular thrombectomy (TM) is now well established. The immuno-inflammatory events of reperfusion after TM are discussed. Systemic inflammation is a major factor suggested to explain the limited recovery of the ischemic parenchyma. Understanding these phenomena is necessary before developing an immunomodulatory strategy.


Eligibility criteria: GROUP "AVC" :

Inclusion Criteria:

* Adults patient (s)
* Ischemic stroke by occlusion of a middle cerebral artery (proximal portion M1)
* Initial diagnostic MRI infusion
* TM with complete reperfusion (TICI 2b, 2c or 3)
* TM performed under local anesthesia +/- anxiolysis, or sedation including propofol
* mRS prior to stroke \<2
* Barthel index \<90
* Included in the HIBISCUS cohort
* Patient who was informed and did not object to participating in the study OR included through the emergency procedure then collection of his non-objection or that of his trusted person as soon as possible

Exclusion Criteria:

* NIHSS awareness score\> or = 2
* Haemorrhagic complication before thrombectomy
* Pregnant woman
* Multiple vascular occlusions
* Occlusions of posterior or anterior cerebral territories other than M1
* Protected major
* TM performed under general anesthesia
* Other vital failure than neurological failure

GROUP "CONTROL" :

Inclusion Criteria:

* Adults patient (s)
* mRS \<2
* Barthel index \<90
* Requiring diagnostic arteriography for routine check-up of a cerebrovascular malformation
* Patient who was informed and did not object to participating in the study

Exclusion Criteria:

* NIHSS awareness score\> or = 2
* Pregnant woman
* Protected major
* Exam performed under general anesthesia

Primary outcomes:
measure: Inflammation parameters description
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Bron
country: France
facility: Service d'Anesthésie Réanimation Hôpital - Neurologique/Groupement Est
city: Bron
country: France
facility: Service de Neurologie vasculaire - Hôpital Neurologique/Groupement Est
city: Bron
country: France
facility: Service de Neuroradiologie interventionnelle - Hôpital Neurologique/Groupement Est
city: Lyon
country: France
facility: Service d'Anesthésie Réanimation - Hôpital Edouard Herriot/Groupement Centre
Study officials:
References: