Clinical trial NCT05581303: Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
Official title: A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Participants With Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Atherosclerotic Cardiovascular Disease
Keywords: Atherosclerotic Cardiovascular Disease
ASCVD
AMG 890
Olpasiran
Lead sponsor: Amgen
Sponsor class: INDUSTRY
First posted: 2022-10-14
Enrollment: 7297
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary objective of this study is to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants with atherosclerotic cardiovascular disease (ASCVD) and elevated Lipoprotein(a).


Eligibility criteria: Inclusion Criteria:

* Age 18 to ≤ 85 years
* Lp(a)≥ 200 nmol/L during screening
* History of ASCVD as evidenced by history of either:

  * Myocardial infarction (presumed type 1 event due to plaque rupture/erosion) and/or
  * Coronary revascularization with percutaneous coronary intervention AND at least 1 additional risk factor.

Exclusion Criteria:

* Severe renal dysfunction
* Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \> 3 x upper limit of normal (ULN), or total bilirubin (TBL) \> 2 x ULN during screening
* History of hemorrhagic stroke
* History of major bleeding disorder
* Planned cardiac surgery or arterial revascularization
* Severe heart failure
* Current, recent, or planned lipoprotein apheresis
* Previously received ribonucleic acid therapy specifically targeting Lp(a)

Primary outcomes:
measure: Time to CHD death, myocardial infarction, or urgent coronary revascularization, whichever occurs first
timeFrame: Approximately 4 years
Secondary outcomes:
measure: Time to cardiovascular death, myocardial infarction, or ischemic stroke, whichever occurs first
timeFrame: Approximately 4 years
measure: Time to cardiovascular death, myocardial infarction, urgent coronary revascularization, or ischemic stroke, whichever occurs first
timeFrame: Approximately 4 years
measure: Percent change from baseline to Week 48 in Lipoprotein(a)
timeFrame: Baseline and Week 48
measure: Time to myocardial infarction
timeFrame: Approximately 4 years
measure: Time to CHD death or myocardial infarction, whichever occurs first
timeFrame: Approximately 4 years
measure: Time to urgent coronary revascularization
timeFrame: Approximately 4 years
measure: Time to coronary revascularization
timeFrame: Approximately 4 years
measure: Time to CHD death
timeFrame: Approximately 4 years
measure: Time to cardiovascular death
timeFrame: Approximately 4 years
measure: Time to death by any cause
timeFrame: Approximately 4 years
measure: Time to ischemic stroke
timeFrame: Approximately 4 years
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Ascension Saint Vincents Birmingham
state: Alabama
city: Birmingham
country: United States
facility: Grandview Medical Center Affinity Cardiovascular Specialists, LLC
state: Alabama
city: Huntsville
country: United States
facility: Heart Center Research LLC
state: Alabama
city: Mobile
country: United States
facility: Mobile Heart Specialists PC
state: Alabama
city: Anchorage
country: United States
facility: Alaska Cardiovascular Research Foundation
state: Alaska
city: Phoenix
country: United States
facility: Elite Clinical Studies LLC
state: Arizona
city: Scottsdale
country: United States
facility: HonorHealth Research and Innovation Institute
state: Arizona
city: Beverly Hills
country: United States
facility: National Heart Institute
state: California
city: Beverly Hills
country: United States
facility: Vitality Clinical Research
state: California
city: La Jolla
country: United States
facility: University of California San Diego
state: California
city: Los Angeles
country: United States
facility: VA Greater Los Angeles Healthcare System
state: California
city: Orange
country: United States
facility: University of California Irvine
state: California
city: Santa Monica
country: United States
facility: University of California Los Angeles
state: California
city: Stockton
country: United States
facility: Manshadi Heart Institute
state: California
city: Toluca Lake
country: United States
facility: Med Partners, Inc dba Premiere Medical Center, Inc
state: California
city: Colorado Springs
country: United States
facility: UCHealth Memorial Central
state: Colorado
city: Stamford
country: United States
facility: Cardiology Associates of Fairfield County PC
state: Connecticut
city: Washington
country: United States
facility: MedStar Clinical Research
state: District of Columbia
city: Boca Raton
country: United States
facility: Excel Medical Clinical Trials
state: Florida
city: Brandon
country: United States
facility: Bay Area Cardiology
state: Florida
city: Clearwater
country: United States
facility: Clearwater Cardiovascular Consultants
state: Florida
city: Daytona Beach
country: United States
facility: Cardiology Associates Research LLC
state: Florida
city: Fort Lauderdale
country: United States
facility: Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care
state: Florida
city: Hialeah
country: United States
facility: Elite Cardiac Research Center LLC
state: Florida
city: Jacksonville
country: United States
facility: East Coast Institute for Research, LLC
state: Florida
city: Jacksonville
country: United States
facility: Westside Center for Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: University of Florida
state: Florida
city: Jacksonville
country: United States
facility: East Coast Institute for Research LLC
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Center for Clinical Research
state: Florida
city: Naples
country: United States
facility: Advanced Research for Health Improvement, LLC
state: Florida
city: Ocala
country: United States
facility: Ocala Cardiovascular Research
state: Florida
city: Orlando
country: United States
facility: AdventHealth Medical Group Cardiology at Orlando
state: Florida
city: Saint Augustine
country: United States
facility: East Coast Institute for Research, LLC
state: Florida
city: Saint Augustine
country: United States
facility: Saint Johns Center for Clinical Research
state: Florida
city: Sarasota
country: United States
facility: Cardiovascular Center of Sarasota
state: Florida
city: Tampa
country: United States
facility: Care Access - Tampa
state: Florida
city: Atlanta
country: United States
facility: Piedmont Healthcare
state: Georgia
city: Atlanta
country: United States
facility: Morehouse School of Medicine
state: Georgia
city: Cumming
country: United States
facility: Northeast Georgia Medical Center Wisteria Building
state: Georgia
city: Johns Creek
country: United States
facility: NSC Research
state: Georgia
city: Meridian
country: United States
facility: St Lukes Idaho Cardiology Associates
state: Idaho
city: Arlington Heights
country: United States
facility: Northwest Heart Clinical Research LLC
state: Illinois
city: Evanston
country: United States
facility: Northshore University Health System
state: Illinois
city: Park Ridge
country: United States
facility: Advocate Lutheran General Hospital
state: Illinois
city: Munster
country: United States
facility: Cardiovascular Research of Northwest Indiana LLC
state: Indiana
city: Richmond
country: United States
facility: Reid Physician Associates
state: Indiana
city: West Des Moines
country: United States
facility: MercyOne Iowa Heart Center
state: Iowa
city: Kansas City
country: United States
facility: University of Kansas Medical Center
state: Kansas
city: Overland Park
country: United States
facility: Midwest Heart and Vascular Specialists
state: Kansas
city: Covington
country: United States
facility: Saint Elizabeth Covington
state: Kentucky
city: Lexington
country: United States
facility: The Research Group of Lexington LLC
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville Health - Jewish Hospital
state: Kentucky
city: Hammond
country: United States
facility: Louisiana Heart Center
state: Louisiana
city: Lake Charles
country: United States
facility: Care Access - Lake Charles
state: Louisiana
city: Monroe
country: United States
facility: Clinical Trials of America Inc
state: Louisiana
city: West Monroe
country: United States
facility: Monroe Research LLC
state: Louisiana
city: Bangor
country: United States
facility: Northern Light Eastern Maine Medical Center
state: Maine
city: Baltimore
country: United States
facility: University of Maryland Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Maryland Cardiovascular Specialists
state: Maryland
city: Baltimore
country: United States
facility: Johns Hopkins University School of Medicine
state: Maryland
city: Beltsville
country: United States
facility: Metropolitan Cardiovascular Consultants LLC
state: Maryland
city: Salisbury
country: United States
facility: TidalHealth Peninsula Regional, Inc
state: Maryland
city: Boston
country: United States
facility: Brigham and Womens Hospital
state: Massachusetts
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Detroit
country: United States
facility: Ascension Saint John Hospital
state: Michigan
city: Grand Rapids
country: United States
facility: Advanced Cardiology Associates
state: Michigan
city: Grand Rapids
country: United States
facility: Healthy Heart Cardiology
state: Michigan
city: Lansing
country: United States
facility: Sparrow Clinical Research Institute
state: Michigan
city: Troy
country: United States
facility: Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division
state: Michigan
city: Maplewood
country: United States
facility: Fairview Health Services
state: Minnesota
city: Minneapolis
country: United States
facility: Minneapolis Heart Institute Foundation
state: Minnesota
city: Minneapolis
country: United States
facility: University of Minnesota
state: Minnesota
city: Rochester
country: United States
facility: Mayo Clinic Rochester
state: Minnesota
city: Tupelo
country: United States
facility: Cardiology Associates Research LLC
state: Mississippi
city: Saint Louis
country: United States
facility: Saint Louis Heart and Vascular PC
state: Missouri
city: Lincoln
country: United States
facility: Bryan Heart
state: Nebraska
city: Las Vegas
country: United States
facility: Palm Research Center Inc
state: Nevada
city: Reno
country: United States
facility: Renown Institute for Heart and Vascular Health
state: Nevada
city: Newark
country: United States
facility: Saint Michaels Medical Center
state: New Jersey
city: Summit
country: United States
facility: Overlook Medical Center
state: New Jersey
city: Cortlandt Manor
country: United States
facility: New York Presbyterian Medical Group Hudson Valley Cardiology
state: New York
city: Kew Gardens
country: United States
facility: Elligo Health Research
state: New York
city: Kingston
country: United States
facility: WMCHealth Heart and Vascular Institute Kingston Division of Cardiology
state: New York
city: Manhasset
country: United States
facility: Northwell Health Physician Partners Cardiology at Manhasset
state: New York
city: New York
country: United States
facility: New York University Langone Health
state: New York
city: New York
country: United States
facility: Northwell Health Lenox Hill Heart and Vascular
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai Queens
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai
state: New York
city: Riverhead
country: United States
facility: Northwell Health Physician Partners at Peconic
state: New York
city: Stony Brook
country: United States
facility: Stony Brook University Hospital
state: New York
city: Valhalla
country: United States
facility: Westchester Medical Center
state: New York
city: Woodhaven
country: United States
facility: NY Family Docs
state: New York
city: Asheville
country: United States
facility: Asheville Cardiology Associates
state: North Carolina
city: Charlotte
country: United States
facility: Novant Health Heart and Vascular Institute
state: North Carolina
city: Durham
country: United States
facility: Duke University
state: North Carolina
city: Greensboro
country: United States
facility: Moses H Cone Memorial Hospital
state: North Carolina
city: Mooresville
country: United States
facility: Lapis Clinical Research
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest University Health Sciences
state: North Carolina
city: Fargo
country: United States
facility: Lillestol Research LLC
state: North Dakota
city: Cincinnati
country: United States
facility: TriHealth Good Samaritan Hospital
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals Cleveland Medical Center
state: Ohio
city: Columbus
country: United States
facility: The OhioHealth Research Institute
state: Ohio
city: Kettering
country: United States
facility: Kettering Medical Center
state: Ohio
city: Marion
country: United States
facility: Rama Research LLC
state: Ohio
city: Portland
country: United States
facility: Oregon Health and Science University
state: Oregon
city: Newport
country: United States
facility: Capital Area Research LLC
state: Pennsylvania
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
city: Philadelphia
country: United States
facility: Montefiore Medical Center - Bronx
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Allegheny General Hospital
state: Pennsylvania
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: Columbia
country: United States
facility: Prisma Health Midlands Cardiology
state: South Carolina
city: Fort Mill
country: United States
facility: Piedmont Research Partners
state: South Carolina
city: Rapid City
country: United States
facility: Monument Health Clinical Research
state: South Dakota
city: Germantown
country: United States
facility: Stern Cardiovascular Foundation Inc
state: Tennessee
city: Tullahoma
country: United States
facility: Tennessee Center for Clinical Trials
state: Tennessee
city: Austin
country: United States
facility: Texas Diabetes and Endocrinology
state: Texas
city: Dallas
country: United States
facility: Baylor Scott and White Heart and Vascular Hospital-Dallas
state: Texas
city: Dallas
country: United States
facility: Southwest Family Medicine Associates
state: Texas
city: El Paso
country: United States
facility: David Turbay, MD
state: Texas
city: Georgetown
country: United States
facility: Care Access - Georgetown
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine
state: Texas
city: Kingwood
country: United States
facility: Texas Cardiology Associates of Houston
state: Texas
city: McKinney
country: United States
facility: Texas Institute of Cardiology
state: Texas
city: Odessa
country: United States
facility: Permian Research Foundation
state: Texas
city: Tomball
country: United States
facility: Northwest Houston Heart Center
state: Texas
city: Fairfax
country: United States
facility: Inova Heart and Vascular Institute
state: Virginia
city: Falls Church
country: United States
facility: Virginia Heart
state: Virginia
city: Leesburg
country: United States
facility: Virginia Heart - Loudoun
state: Virginia
city: Manassas
country: United States
facility: Carient Heart and Vascular
state: Virginia
city: Midlothian
country: United States
facility: Bon Secours Cardiology
state: Virginia
city: Newport News
country: United States
facility: Tidewater Physicians Multispecialty Group Clinical Research
state: Virginia
city: Winchester
country: United States
facility: Winchester Cardiology and Vascular Medicine
state: Virginia
city: Puyallup
country: United States
facility: Pulse Heart Institute
state: Washington
city: Bahia Blanca
country: Argentina
facility: Instituto de Investigaciones Clinicas Bahia Blanca
state: Buenos Aires
city: Caba
country: Argentina
facility: Cedic Centro de Investigacion Clinica
state: Buenos Aires
city: Caba
country: Argentina
facility: Ciprec Centro de Investigacion y Prevencion Cardiovascular
state: Buenos Aires
city: Caba
country: Argentina
facility: Cinme - Centro de Investigaciones Metabolicas
state: Buenos Aires
city: Caba
country: Argentina
facility: Consultorio Medico Dr Litvak Bruno
state: Buenos Aires
city: Caba
country: Argentina
facility: Cemedic Centro de Especialidades Medicas
state: Buenos Aires
city: Caba
country: Argentina
facility: Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada
state: Buenos Aires
city: Caba
country: Argentina
facility: Consultorios Medicos Dr Besada
state: Buenos Aires
city: Caba
country: Argentina
facility: Fundacion Respirar - Consultorios Medicos Dr Doreski
state: Buenos Aires
city: Ciudad Autonoma de Buenos Aires
country: Argentina
facility: Glenny Corp SA
state: Buenos Aires
city: Ciudad Autonoma de Buenos Aires
country: Argentina
facility: Fundacion Favaloro
state: Buenos Aires
city: Ciudad Autonoma de Buenos Aires
country: Argentina
facility: Icba Instituto Cardiovascular de Buenos Aires
state: Buenos Aires
city: Cuidad Autonoma de Buenos Aires
country: Argentina
facility: Hospital Italiano de Buenos Aires
state: Buenos Aires
city: Moron
country: Argentina
facility: Ciad - Consultorio Integral de Atencion al Diabetico
state: Buenos Aires
city: Quilmes
country: Argentina
facility: Instituto de Investigaciones Clinicas Quilmes
state: Buenos Aires
city: San Nicolas
country: Argentina
facility: Instituto de Investigaciones Clinicas de San Nicolas
state: Buenos Aires
city: Zarate
country: Argentina
facility: Instituto de Investigaciones Clinicas Zarate
state: Buenos Aires
city: Cordoba
country: Argentina
facility: Clinica Privada del Prado
state: Córdoba
city: Cordoba
country: Argentina
facility: Instituto Latinoamericano de Investigaciones Medicas Cidim-Ilaim
state: Córdoba
city: Cordoba
country: Argentina
facility: Instituto de Investigaciones Clinicas de Cordoba
state: Córdoba
city: Villa Maria
country: Argentina
facility: Clinica Fusavim Privada SRL
state: Córdoba
city: Rosario
country: Argentina
facility: Instituto de Investigaciones Clinicas Rosario
state: Santa Fe
city: Buenos Aires
country: Argentina
facility: Clinica Adventista Belgrano
city: Córdoba
country: Argentina
facility: Instituto Medico Damic
city: Santa Fe
country: Argentina
facility: Centro de Investigaciones Clinicas del Litoral
city: Garran
country: Australia
facility: Canberra Hospital
state: Australian Capital Territory
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital
state: New South Wales
city: Concord
country: Australia
facility: Concord Repatriation General Hospital
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital
state: New South Wales
city: Sydney
country: Australia
facility: Holdsworth House Medical Practice
state: New South Wales
city: Wollongong
country: Australia
facility: Wollongong Hospital
state: New South Wales
city: Auchenflower
country: Australia
facility: Advara HeartCare Wesley
state: Queensland
city: Bundaberg
country: Australia
facility: Advara HeartCare Bundaberg
state: Queensland
city: Herston
country: Australia
facility: Royal Brisbane and Womens Hospital
state: Queensland
city: Milton
country: Australia
facility: Core Research Group Pty Ltd
state: Queensland
city: Woolloongabba
country: Australia
facility: Dr Heart Pty Ltd
state: Queensland
city: Adelaide
country: Australia
facility: Nightingale Research
state: South Australia
city: Bedford Park
country: Australia
facility: Flinders Medical Centre
state: South Australia
city: Leabrook
country: Australia
facility: Advara HeartCare Leabrook
state: South Australia
city: Hobart
country: Australia
facility: Royal Hobart Hospital
state: Tasmania
city: Berwick
country: Australia
facility: Advara HeartCare Berwick
state: Victoria
city: Clayton
country: Australia
facility: Victorian Heart Hospital
state: Victoria
city: Epping
country: Australia
facility: The Cardiologists Proprietary Limited
state: Victoria
city: Geelong
country: Australia
facility: Barwon Health Geelong Hospital
state: Victoria
city: Ringwood
country: Australia
facility: Advara HeartCare Ringwood
state: Victoria
city: Joondalup
country: Australia
facility: Advara HeartCare Joondalup
state: Western Australia
city: Murdoch
country: Australia
facility: Mount Hospital
state: Western Australia
city: Nedlands
country: Australia
facility: Linear Clinical Research Limited
state: Western Australia
city: Feldkirch
country: Austria
facility: Landeskrankenhaus Feldkirch
city: Graz
country: Austria
facility: Medizinische Universitaet Graz
city: Klagenfurt
country: Austria
facility: Klinikum Klagenfurt am Woerthersee
city: Linz
country: Austria
facility: Krankenhaus der Barmherzigen Brueder Linz
city: Salzburg
country: Austria
facility: Landeskrankenhaus Salzburg
city: Sankt Poelten
country: Austria
facility: Universitaetsklinikum Sankt Poelten
city: Wien
country: Austria
facility: Klinik Landstrasse
city: Wien
country: Austria
facility: Universitaetsklinikum Allgemeines Krankenhaus Wien
city: Wien
country: Austria
facility: Klinik Hietzing
city: Wien
country: Austria
facility: Klinik Ottakring
city: Wien
country: Austria
facility: Krankenhaus Nord - Klinik Floridsdorf
city: Aalst
country: Belgium
facility: Algemeen Stedelijk Ziekenhuis Aalst
city: Aalst
country: Belgium
facility: Onze Lieve Vrouw Ziekenhuis - campus Aalst
city: Antwerpen
country: Belgium
facility: Ziekenhuisnetwerk Antwerpen site Cadix
city: Brussels
country: Belgium
facility: Cliniques universitaires de Bruxelles Hopital Erasme
city: Dendermonde
country: Belgium
facility: Algemeen Ziekenhuis Sint Blasius
city: Edegem
country: Belgium
facility: Universitair Ziekenhuis Antwerpen
city: Genk
country: Belgium
facility: Ziekenhuis Oost-Limburg - Campus Sint-Jan
city: Gent
country: Belgium
facility: Algemeen Ziekenhuis Sint Lucas
city: Hasselt
country: Belgium
facility: Jessa Ziekenhuis - Campus Virga Jesse
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven - Campus Gasthuisberg
city: Liège
country: Belgium
facility: Centre Hospitalier Regional de la Citadelle
city: Mechelen
country: Belgium
facility: Algemeen Ziekenhuis Sint-Maarten
city: Turnhout
country: Belgium
facility: Algemeen Ziekenhuis Turnhout
city: Salvador
country: Brazil
facility: Hospital Santa Izabel
state: Bahia
city: Salvador
country: Brazil
facility: Hospital Ana Nery
state: Bahia
city: Salvador
country: Brazil
facility: Instituto de Ensino e Pesquisa do Hospital da Bahia
state: Bahia
city: Fortaleza
country: Brazil
facility: Hospital Universitario Walter Cantidio
state: Ceará
city: Fortaleza
country: Brazil
facility: Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas
state: Ceará
city: Brasília
country: Brazil
facility: Associacao de Amparo a Saude Ensino e Pesquisa
state: Distrito Federal
city: Vitória
country: Brazil
facility: Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo
state: Espírito Santo
city: Goiania
country: Brazil
facility: Hospital das Clinicas da Universidade Federal de Goias
state: Goiás
city: Campo Grande
country: Brazil
facility: Hospital Universitario Maria Aparecida Pedrossian
state: Mato Grosso Do Sul
city: Uberlandia
country: Brazil
facility: Eurolatino Pesquisas Medicas
state: Minas Gerais
city: Curitiba
country: Brazil
facility: Quanta Diagnostico por Imagem
state: Paraná
city: Curitiba
country: Brazil
facility: Nucleo de Pesquisa Clinica
state: Paraná
city: Recife
country: Brazil
facility: Procape
state: Pernambuco
city: Recife
country: Brazil
facility: Hospital Agamenon Magalhaes
state: Pernambuco
city: Natal
country: Brazil
facility: Instituto Atena de Pesquisa Clínica
state: Rio Grande Do Norte
city: Porto Alegre
country: Brazil
facility: Hospital Sao Francisco da Santa Casa de Misericordia de Porto Alegre
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Centro de Pesquisa Clínica Associação Hospitalar Moinhos de Vento
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital das Clinicas de Porto Alegre
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Nucleo de Pesquisa Clinica do Rio Grande do Sul
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Instituto de Cardiologia do Rio Grande do Sul
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Imv Pesquisa Cardiologica
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: FZ Pesquisa e Servicos em Cardiologia LTDA
state: Rio Grande Do Sul
city: Blumenau
country: Brazil
facility: AngioCor Blumenau
state: Santa Catarina
city: Aracaju
country: Brazil
facility: jmf Clinica do Coracao ltda
state: Sergipe
city: Campinas
country: Brazil
facility: Instituto de Pesquisa Clínica de Campinas
state: São Paulo
city: Campinas
country: Brazil
facility: Loema Instituto de Pesquisa Clinica e Consultores Ltda
state: São Paulo
city: Marilia
country: Brazil
facility: icm Instituto do Coração de Marilia
state: São Paulo
city: Ribeirao Preto
country: Brazil
facility: Hospital Das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo
state: São Paulo
city: Ribeirão Preto
country: Brazil
facility: Clinicor Clinica Cardiologica Ltda
state: São Paulo
city: Sao Jose do Rio Preto
country: Brazil
facility: Hospital de Base de Sao Jose do Rio Preto
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Instituto de Pesquisa em Endocrinologia Clinica IPEC
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Sociedade Beneficente de Senhoras Hospital Sirio Libanes
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Instituto Dante Pazzanese de Cardiologia
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
state: São Paulo
city: Votuporanga
country: Brazil
facility: Integral Pesquisa e Ensino
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: IBPClin Instituto Brasil de Pesquisa Clinica
city: Rio de Janeiro
country: Brazil
facility: Fundacao Pro-Coracao
city: São Paulo
country: Brazil
facility: Centro Paulista de Investigacoes Clinicas Cepic
city: Blagoevgrad
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Puls AD
city: Haskovo
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment - Haskovo AD
city: Pleven
country: Bulgaria
facility: Medical Center Medconsult Pleven OOD
city: Pleven
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Heart and Brain EAD
city: Sliven
country: Bulgaria
facility: Medical Center Cardiomed 2020 EOOD
city: Sofia
country: Bulgaria
facility: Diagnostic-Consultative Center Ascendent OOD
city: Sofia
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment National Hospital of Cardiology EAD
city: Sofia
country: Bulgaria
facility: Acibadem City Clinic University Multiprofile Hospital for Active Treatment EOOD
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
city: Sofia
country: Bulgaria
facility: Medical Center Kalimat EOOD
city: Sofia
country: Bulgaria
facility: Medical Centre Synexus Sofia EOOD
city: Stara Zagora
country: Bulgaria
facility: Medical Center Orpheus OOD
city: Varna
country: Bulgaria
facility: Ambulatory for Individual Practice for Specialized Medical Care - Kardio EOOD
city: Vancouver
country: Canada
facility: ARC Biosystems Incorporated
state: British Columbia
city: Victoria
country: Canada
facility: Victoria Heart Institute Foundation
state: British Columbia
city: Victoria
country: Canada
facility: Discovery Clinical Services Ltd
state: British Columbia
city: Brampton
country: Canada
facility: LMC Clinical Research Incorporated
state: Ontario
city: Brampton
country: Canada
facility: Brampton Clinical Trials
state: Ontario
city: Cambridge
country: Canada
facility: Cambridge Cardiac Care Centre
state: Ontario
city: Concord
country: Canada
facility: LMC Clinical Research Incorporated Thornhill
state: Ontario
city: Hamilton
country: Canada
facility: Hamilton Health Sciences Hamilton General Hospital
state: Ontario
city: Mississauga
country: Canada
facility: One Heart Care
state: Ontario
city: North York
country: Canada
facility: North York Diagnostic and Cardiac Centre
state: Ontario
city: Oakville
country: Canada
facility: Oakville Cardiovascular Research
state: Ontario
city: Toronto
country: Canada
facility: Womens College Hospital
state: Ontario
city: Waterloo
country: Canada
facility: CPS Research
state: Ontario
city: Chicoutimi
country: Canada
facility: Ecogene-21 Research
state: Quebec
city: Montreal
country: Canada
facility: Institut de recherches cliniques de Montreal
state: Quebec
city: Montreal
country: Canada
facility: Research Institute of McGill University Health Center - Glen Site
state: Quebec
city: Québec
country: Canada
facility: Centre Hospitalier Universitaire de Quebec, Centre Hotel-Dieu de Quebec
state: Quebec
city: St-Charles-Borromee
country: Canada
facility: Centre de sante et de services sociaux du Nord de Lanaudiere
state: Quebec
city: Quebec
country: Canada
facility: Institut Universitaire de cardiologie et de pneumologie de Quebec
city: Quebec
country: Canada
facility: Clinique des Maladies Lipidiques de Quebec Incorporated
city: Beijing
country: China
facility: Peking University Third Hospital
state: Beijing
city: Beijing
country: China
facility: Beijing Hospital
state: Beijing
city: Guangzhou
country: China
facility: The First Affiliated Hospital ,Sun-Yat Sen University
state: Guangdong
city: Guangzhou
country: China
facility: Sun Yat-sen Memorial Hospital Sun Yat-sen University
state: Guangdong
city: Guangzhou
country: China
facility: Nanfang Hospital, Southern Medical University
state: Guangdong
city: Guangzhou
country: China
facility: Guangdong Provincial Peoples Hospital
state: Guangdong
city: HuiZhou
country: China
facility: Huizhou Central Peoples Hospital
state: Guangdong
city: Nanning
country: China
facility: The Peoples Hospital of Guangxi Zhuang Autonomous Region
state: Guangxi
city: Nanning
country: China
facility: The Second Nanning Peoples Hospital
state: Guangxi
city: Daqing
country: China
facility: Daqing Oilfield general Hospital
state: Heilongjiang
city: Harbin
country: China
facility: The First Affiliated Hospital of Harbin Medical University
state: Heilongjiang
city: Nanyang
country: China
facility: Nanyang Second General Hospital
state: Henan
city: Changsha
country: China
facility: The Second Xiangya Hospital of Central South University
state: Hunan
city: Changsha
country: China
facility: The Third Xiangya Hospital of Central South University
state: Hunan
city: Xiangtan
country: China
facility: Xiangtan Central Hospital
state: Hunan
city: Nanjing
country: China
facility: Nanjing First Hospital
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital
state: Jiangsu
city: Nanjing
country: China
facility: Zhongda Hospital Southeast University
state: Jiangsu
city: Nanjing
country: China
facility: The Second Affiliated Hospital of Nanjing Medical University
state: Jiangsu
city: Suzhou
country: China
facility: The First Affiliated Hospital of Soochow University
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi Peoples Hospital
state: Jiangsu
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical University
state: Jiangsu
city: Nanchang
country: China
facility: The Second Affiliated Hospital to Nanchang University
state: Jiangxi
city: Changchun
country: China
facility: Jilin Province Peoples Hospital
state: Jilin
city: Changchun
country: China
facility: The First Hospital of Jilin University
state: Jilin
city: Changchun
country: China
facility: China-Japan Union Hospital of Jilin University
state: Jilin
city: Shenyang
country: China
facility: The Peoples Hospital of Liaoning Province
state: Liaoning
city: Yinchuan
country: China
facility: General Hospital of Ningxia Medical University
state: Ningxia
city: Xi'an
country: China
facility: Shaanxi Provincial Peoples Hospital
state: Shaanxi
city: Jinan
country: China
facility: Jinan Central Hospital
state: Shandong
city: Chengdu
country: China
facility: West China Hospital of Sichuan University
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
state: Tianjin
city: Tianjin
country: China
facility: Tianjin Peoples Hospital
state: Tianjin
city: Tianjin
country: China
facility: Tianjin Chest Hospital
state: Tianjin
city: Urumqi
country: China
facility: The First Affiliated Hospital of Xinjiang Medical University
state: Xinjiang
city: Hangzhou
country: China
facility: Zhejiang Provincial Peoples Hospital
state: Zhejiang
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University
state: Zhejiang
city: Beijing
country: China
facility: Beijing Friendship Hospital, Capital Medical University
city: Qingdao
country: China
facility: Qingdao Fuwai Cardiovascular Hospital
city: Shanghai
country: China
facility: Shanghai General Hospital
city: Shanghai
country: China
facility: Shanghai Yangpu District Central Hospital（ Yangpu Hospital Affiliated to Tongji University）
city: Wuhan
country: China
facility: Renmin Hospital of Wuhan University
city: Zhejiang
country: China
facility: Zhejiang Hospital
city: Beroun
country: Czechia
facility: Jessenia as, Nemocnice Beroun
city: Bilina
country: Czechia
facility: Hornicka nemocnice s poliklinikou spol sro
city: Brandys nad Labem
country: Czechia
facility: Medicus Services sro
city: Brno
country: Czechia
facility: MTE Medical Center
city: Brno
country: Czechia
facility: Centrum pro zdravi sro
city: Brno
country: Czechia
facility: MUDr Karel Kameník sro
city: Brno
country: Czechia
facility: Kardiologicka ambulance Brno sro
city: Brno
country: Czechia
facility: Kardio Elbl sro
city: Ceske Budejovice
country: Czechia
facility: Nemocnice Ceske Budejovice as
city: Chomutov
country: Czechia
facility: Ordinace pro choroby srdce sro
city: Havirov - Mesto
country: Czechia
facility: Dika centrum sro
city: Holesov
country: Czechia
facility: Kardio Holesov sro
city: Hradec Kralove
country: Czechia
facility: MUDr Ladislava Harrerova, kardiologicka ordinace
city: Hradec Kralove
country: Czechia
facility: Fakultni nemocnice Hradec Kralove
city: Jihlava
country: Czechia
facility: Nemocnice Jihlava po
city: Klatovy IV
country: Czechia
facility: Kardio Michal Cepelak sro
city: Mlada Boleslav
country: Czechia
facility: MUDr Zbynek Kosek, kardiologicka ambulance sro
city: Nachod
country: Czechia
facility: Edumed sro
city: Olomouc
country: Czechia
facility: PreventaMed sro
city: Ostrava - Moravska Ostrava
country: Czechia
facility: Mestska nemocnice Ostrava, po
city: Ostrava-Dubina
country: Czechia
facility: Pedicor Trial sro
city: Ostrava
country: Czechia
facility: Fakultni nemocnice Ostrava
city: Pardubice
country: Czechia
facility: Nemocnice Pardubickeho kraje as
city: Plzen
country: Czechia
facility: Fakultni nemocnice Plzen
city: Policka
country: Czechia
facility: Policska nemocnice sro
city: Praha 10
country: Czechia
facility: Ordinace pro choroby srdce a cev
city: Praha 2
country: Czechia
facility: Vseobecna fakultni nemocnice v Praze
city: Praha 4
country: Czechia
facility: Institut klinicke a experimentalni mediciny
city: Praha 4
country: Czechia
facility: Milan Kvapil sro
city: Praha 5 - Smichov
country: Czechia
facility: Kardiologicke centrum MUDr Janky Skrobakove sro
city: Praha 5
country: Czechia
facility: Interni a kardiologicka ordinace
city: Praha 9
country: Czechia
facility: Endokrinologie Cerny Most sro
city: Prerov
country: Czechia
facility: Kardio Vaclavik sro, Interni a kardiologicka ambulance
city: Pribram VIII
country: Czechia
facility: Poliklinika Ravak Pribram
city: Trutnov
country: Czechia
facility: Kardiologicka ambulance MUDr Ferkl, sro
city: Uherske Hradiste
country: Czechia
facility: Clinical Trials Service sro
city: Zlin
country: Czechia
facility: Cardio Research sro
city: Zlin
country: Czechia
facility: Krajska nemocnice T Bati as
city: Aalborg
country: Denmark
facility: Aalborg Universitetshospital
city: Aarhus N
country: Denmark
facility: Aarhus Universitetshospital
city: Copenhagen O
country: Denmark
facility: Rigshospitalet
city: Esbjerg
country: Denmark
facility: Sydvestjysk Sygehus
city: Gandrup
country: Denmark
facility: Sanos Gandrup
city: Herlev
country: Denmark
facility: Herlev Gentofte Hospital
city: Herlev
country: Denmark
facility: Sanos Clinic
city: Herning
country: Denmark
facility: Regionshospitalet Gødstrup
city: Holbaek
country: Denmark
facility: Holbaek Sygehus
city: Kobenhavn NV
country: Denmark
facility: University of Fredriksberg Hospital
city: Kobenhavn S
country: Denmark
facility: Amager Hospital
city: Roskilde
country: Denmark
facility: Sjaellands Universitetshospital, Roskilde
city: Slagelse
country: Denmark
facility: Slagelse Sygehus
city: Svendborg
country: Denmark
facility: Svendborg Sygehus
city: Vejle
country: Denmark
facility: Sanos Vejle
city: Viborg
country: Denmark
facility: Regionshospitalet Viborg
city: Tallinn
country: Estonia
facility: Innomedica
city: Tallinn
country: Estonia
facility: Center for Clinical and Basic Research Tallinn
city: Tallinn
country: Estonia
facility: North Estonia Medical Centre Foundation
city: Tartu
country: Estonia
facility: Tartu University Hospital
city: Helsinki
country: Finland
facility: Helsinki University Central Hospital
city: Kuopio
country: Finland
facility: Satucon Oy/Kuopion tyoterveys
city: Oulu
country: Finland
facility: Oulu University Hospital
city: Tampere
country: Finland
facility: Tampere University Hospital
city: Turku
country: Finland
facility: Suomen Terveystalo Oy
city: Besancon cedex
country: France
facility: Centre Hospitalier Regional Universitaire de Besancon, Hopital Jean Minjoz
city: Bron cedex
country: France
facility: Hospices Civils de Lyon Groupement Hospitalier Est, Hopital Louis Pradel
city: Chambray les Tours
country: France
facility: Centre Hospitalier Régional Universitaire de Tours - Hôpital Trousseau
city: Compiegne
country: France
facility: Centre Hospitalier Compiegne-Noyon
city: Dijon
country: France
facility: Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand
city: Lille Cedex
country: France
facility: Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez
city: Marseille Cedex 08
country: France
facility: Hopital Saint-Joseph
city: Marseille
country: France
facility: Hopital de la Conception
city: Montpellier cedex 05
country: France
facility: Centre Hospitalier Universitaire de Montpellier - Hopital Lapeyronie
city: Nantes Cedex 1
country: France
facility: Centre Hospitalier Universitaire de Nantes - Hopital Guillaume et Rene Laennec
city: Nice Cedex 1
country: France
facility: Centre Hospitalier Universitaire de Nice - Hopital Pasteur
city: Paris Cedex 13
country: France
facility: Hopital Pitie-Salpetriere
city: Paris Cedex 18
country: France
facility: Hopital Bichat Claude Bernard
city: Paris
country: France
facility: Hopital Saint Antoine
city: Reims
country: France
facility: Centre Hospitalier Universitaire de Reims - Hopital Robert Debre
city: Rennes
country: France
facility: Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
city: Strasbourg
country: France
facility: Centre Hospitalier Universitaire de Strasbourg - Hopital de Hautepierre
city: Toulouse Cedex 9
country: France
facility: Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
city: Valenciennes
country: France
facility: Polyclinique Vauban
city: Aachen
country: Germany
facility: Universitaetsklinikum Aachen
city: Bad Krozingen
country: Germany
facility: Universitaets-Herzzentrum Freiburg - Bad Krozingen
city: Bad Oeynhausen
country: Germany
facility: Universitaetsklinikum der Ruhr-Universitaet Bochum
city: Berlin
country: Germany
facility: Velocity Clinical Research GmbH
city: Berlin
country: Germany
facility: Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin
city: Berlin
country: Germany
facility: Charite - Universitaetsmedizin Berlin, Campus Virchow
city: Bremen
country: Germany
facility: Klinikum Links der Weser
city: Dresden
country: Germany
facility: Universitaetsklinikum Dresden
city: Essen
country: Germany
facility: Universitaetsklinikum Essen
city: Frankfurt am Main
country: Germany
facility: Universitaetsklinikum Frankfurt
city: Frankfurt am Main
country: Germany
facility: ClinPhenomics CVC GmbH
city: Goettingen
country: Germany
facility: Evangelisches Krankenhaus Goettingen-Weende
city: Goettingen
country: Germany
facility: Universitaetsmedizin Goettingen - Georg-August-Universitaet
city: Hamburg
country: Germany
facility: Universitaetsklinikum Hamburg-Eppendorf
city: Hamburg
country: Germany
facility: Cardiologicum Hamburg GbR
city: Heidelberg
country: Germany
facility: Universitaetsklinikum Heidelberg
city: Kassel
country: Germany
facility: B Braun Ambulantes Herzzentrum Kassel mvz GmbH
city: Koeln
country: Germany
facility: Universitaetsklinikum Koeln
city: Leipzig
country: Germany
facility: Universitaetsklinikum Leipzig
city: Magdeburg
country: Germany
facility: Otto von Guericke Universitaet Magdeburg
city: Mannheim
country: Germany
facility: Universitaetsklinikum Mannheim
city: Markkleeberg
country: Germany
facility: Kardiologische Praxis Doktor Jens Taggeselle
city: Muenchen
country: Germany
facility: Klinikum rechts der Isar der TUM
city: Muenster
country: Germany
facility: Universitaetsklinikum Muenster
city: Papenburg
country: Germany
facility: Kardiologische Gemeinschaftspraxis Papenburg
city: Remscheid
country: Germany
facility: Sana-Klinikum Remscheid GmbH
city: Rostock
country: Germany
facility: Lipidambulanz der Universitaet Rostock
city: Ruedersdorf
country: Germany
facility: Klinik am See - Ruedersdorf
city: Singen
country: Germany
facility: Hegau-Bodensee-Klinikum Singen
city: Witten
country: Germany
facility: Forschungszentrum Ruhr
city: Athens
country: Greece
facility: General Hospital of Athens Evaggelismos
city: Athens
country: Greece
facility: Athens Naval Hospital
city: Athens
country: Greece
facility: General Hospital of Athens Ippokrateio
city: Athens
country: Greece
facility: Laiko General Hospital
city: Athens
country: Greece
facility: Alexandra Hospital
city: Athens
country: Greece
facility: Attikon Hospital
city: Athens
country: Greece
facility: Konstantopoulio - Agia Olga Hospital of Nea Ionia
city: Athens
country: Greece
facility: Hygeia Hospital
city: Athens
country: Greece
facility: Metropolitan Hospital
city: Heraklion
country: Greece
facility: University Hospital of Heraklion
city: Ioannina
country: Greece
facility: University Hospital of Ioannina
city: Mitilini
country: Greece
facility: General Hospital of Mitilini Vostanio
city: Thessaloniki
country: Greece
facility: General Hospital of Thessaloniki Ahepa
city: Hong Kong
country: Hong Kong
facility: University of Hong Kong, Queen Mary Hospital
city: Shatin, New Territories
country: Hong Kong
facility: Prince of Wales Hospital
city: Baja
country: Hungary
facility: Lausmed Kft
city: Bekescsaba
country: Hungary
facility: Dr Lakatos Ferenc Private Cardiology Practice
city: Budapest
country: Hungary
facility: Budapesti Szent Ferenc Korhaz
city: Budapest
country: Hungary
facility: High Tech Medical Kft
city: Budapest
country: Hungary
facility: Clinexpert Kft
city: Budapest
country: Hungary
facility: Gottsegen Gyorgy Orszagos Kardiovaszkularis Intezet
city: Budapest
country: Hungary
facility: Semmelweis Egyetem Varosmajori Sziv es Ergyogyaszati Klinika
city: Budapest
country: Hungary
facility: Eszak-Pesti Centrum Korhaz - Honvedkorhaz
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont
city: Gyongyos
country: Hungary
facility: Pharma4 Trial Kft
city: Hatvan
country: Hungary
facility: BKS Research Kft
city: Komarom
country: Hungary
facility: Selye Janos Korhaz
city: Miskolc
country: Hungary
facility: Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz
city: Oroshaza
country: Hungary
facility: Dr Nagy Laszlo Kardiologiai maganrendeles es SMO
city: Szekesfehervar
country: Hungary
facility: Vita Verum Medical Bt
city: Zalaegerszeg
country: Hungary
facility: Belvarosi Egeszseghaz Kft
city: Zalaegerszeg
country: Hungary
facility: Obudai Egeszsegugyi Centrum Kft
city: Kopavogur
country: Iceland
facility: Hjartamidstodin
city: Kopavogur
country: Iceland
facility: Thjonustumidstod Rannsoknaverkefna
city: Arzignano
country: Italy
facility: Ospedali dell Ovest Vicentino
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola
city: Brescia
country: Italy
facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
city: Caserta
country: Italy
facility: Azienda Ospedaliera Sant Anna e San Sebastiano
city: Catania
country: Italy
facility: Azienda Ospedaliera Cannizzaro
city: Catanzaro
country: Italy
facility: Azienda Ospedaliera Universitaria Renato Dulbecco
city: Cona FE
country: Italy
facility: Azienda Ospedaliera Universitaria di Ferrara Arcispedale Sant Anna
city: Firenze
country: Italy
facility: Azienda Ospedaliero Universitaria Careggi
city: Genova
country: Italy
facility: Ospedale Policlinico San Martino IRCCS
city: Milano
country: Italy
facility: IRCCS Centro Cardiologico Monzino
city: Milano
country: Italy
facility: Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
city: Napoli
country: Italy
facility: Azienda Ospedaliera Universitaria Federico II
city: Palermo
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
city: Rivoli
country: Italy
facility: Ospedale degli Infermi di Rivoli
city: Roma
country: Italy
facility: Fondazione Policlinico Tor Vergata
city: Roma
country: Italy
facility: Azienda Ospedaliera Policlinico Umberto I
city: Rozzano MI
country: Italy
facility: IRCCS Istituto Clinico Humanitas
city: Salerno
country: Italy
facility: Azienda Ospedaliera Universitaria Ospedale San Giovanni di Dio e Ruggi D Aragona
city: Sesto San Giovanni (MI)
country: Italy
facility: Multimedica
city: Torino
country: Italy
facility: Azienda Ospedaliera Ordine Mauriziano di Torino
city: Kasugai-shi
country: Japan
facility: Kasugai Municipal Hospital
state: Aichi
city: Nagoya-shi
country: Japan
facility: Nagoya University Hospital
state: Aichi
city: Seto-shi
country: Japan
facility: Tosei General Hospital
state: Aichi
city: Toyoake-shi
country: Japan
facility: Fujita Health University Hospital
state: Aichi
city: Hirosaki-shi
country: Japan
facility: Hirosaki University Hospital
state: Aomori
city: Asahi-shi
country: Japan
facility: Asahi General Hospital
state: Chiba
city: Matsudo-shi
country: Japan
facility: New Tokyo Heart Clinic
state: Chiba
city: Yoshida-gun
country: Japan
facility: University of Fukui Hospital
state: Fukui
city: Fukuoka-shi
country: Japan
facility: Fukuoka University Hospital
state: Fukuoka
city: Kitakyushu-shi
country: Japan
facility: Kokura Memorial Hospital
state: Fukuoka
city: Kitakyushu-shi
country: Japan
facility: Japan Community Health care Organization Kyushu Hospital
state: Fukuoka
city: Gifu-shi
country: Japan
facility: Gifu Heart Center
state: Gifu
city: Ogaki-shi
country: Japan
facility: Ogaki Municipal Hospital
state: Gifu
city: Hiroshima-shi
country: Japan
facility: Hiroshima City Hiroshima Citizens Hospital
state: Hiroshima
city: Asahikawa-shi
country: Japan
facility: Asahikawa City Hospital
state: Hokkaido
city: Hakodate-shi
country: Japan
facility: Hakodate Municipal Hospital
state: Hokkaido
city: Tomakomai-shi
country: Japan
facility: Tomakomai City Hospital
state: Hokkaido
city: Himeji-shi
country: Japan
facility: Hyogo Prefectural Harima-Himeji General Medical Center
state: Hyogo
city: Kobe-shi
country: Japan
facility: Kobe City Medical Center General Hospital
state: Hyogo
city: Kahoku-gun
country: Japan
facility: Kanazawa Medical University Hospital
state: Ishikawa
city: Kanazawa-shi
country: Japan
facility: Kanazawa University Hospital
state: Ishikawa
city: Morioka-shi
country: Japan
facility: Iwate Prefectural Central Hospital
state: Iwate
city: Takamatsu-shi
country: Japan
facility: Takamatsu Red Cross Hospital
state: Kagawa
city: Takamatsu-shi
country: Japan
facility: Kagawa Prefectural Central Hospital
state: Kagawa
city: Kagoshima-shi
country: Japan
facility: Kagoshima City Hospital
state: Kagoshima
city: Kagoshima-shi
country: Japan
facility: Tenyoukai Chuo Clinic
state: Kagoshima
city: Fujisawa-shi
country: Japan
facility: Fujisawa City Hospital
state: Kanagawa
city: Isehara-shi
country: Japan
facility: Tokai University Hospital
state: Kanagawa
city: Sagamihara-shi
country: Japan
facility: Kitasato University Hospital
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Showa University Fujigaoka Hospital
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Yokohama City University Medical Center
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Yokohama Minami Kyousai Hospital
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Yokohama Sakae Kyosai Hospital Federation of National Public Service Personnel Mutual Association
state: Kanagawa
city: Kochi-shi
country: Japan
facility: Chikamori Hospital
state: Kochi
city: Kumamoto-shi
country: Japan
facility: Kumamoto University Hospital
state: Kumamoto
city: Kumamoto-shi
country: Japan
facility: Saiseikai Kumamoto Hospital
state: Kumamoto
city: Sendai-shi
country: Japan
facility: Tohoku University Hospital
state: Miyagi
city: Sendai-shi
country: Japan
facility: Sendai Cardiovascular Center
state: Miyagi
city: Miyazaki-shi
country: Japan
facility: Miyazaki Medical Association Hospital
state: Miyazaki
city: Matsumoto-shi
country: Japan
facility: Shinshu University Hospital
state: Nagano
city: Niigata-shi
country: Japan
facility: Niigata University Medical and Dental Hospital
state: Niigata
city: Kurashiki-shi
country: Japan
facility: Kawasaki Medical School Hospital
state: Okayama
city: Izumisano-shi
country: Japan
facility: Rinku General Medical Center
state: Osaka
city: Osaka-shi
country: Japan
facility: Sakurabashi Watanabe Advanced Healthcare Hospital
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka City General Hospital
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka Police Hospital
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka Metropolitan University Hospital
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka General Medical Center
state: Osaka
city: Suita-shi
country: Japan
facility: Osaka University Hospital
state: Osaka
city: Saga-shi
country: Japan
facility: Saga-ken Medical Centre Koseikan
state: Saga
city: Ageo-shi
country: Japan
facility: Ageo Central General Hospital
state: Saitama
city: Saitama-shi
country: Japan
facility: Sanai Hospital
state: Saitama
city: Sunto-gun
country: Japan
facility: National Hospital Organization Shizuoka Medical Center
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Juntendo University Hospital
state: Tokyo
city: Chuo-ku
country: Japan
facility: Tokyo-Eki Center-building Clinic
state: Tokyo
city: Hachioji-shi
country: Japan
facility: Minamino Cardiovascular Hospital
state: Tokyo
city: Meguro-ku
country: Japan
facility: National Hospital Organization Tokyo Medical Center
state: Tokyo
city: Musashino-shi
country: Japan
facility: Japanese Red Cross Musashino Hospital
state: Tokyo
city: Ome-shi
country: Japan
facility: Ome Medical Center
state: Tokyo
city: Shinagawa-ku
country: Japan
facility: Showa University Hospital
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Womens Medical University Hospital
state: Tokyo
city: Toyama-shi
country: Japan
facility: Toyama Prefectural Central Hospital
state: Toyama
city: Wakayama-shi
country: Japan
facility: Seiyu Memorial Hospital
state: Wakayama
city: Shunan-shi
country: Japan
facility: Tokuyama Central Hospital
state: Yamaguchi
city: Chuo-shi
country: Japan
facility: University of Yamanashi Hospital
state: Yamanashi
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Seongnam-si, Gyeonggi-do
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea Seoul St Marys Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Ulsan
country: Korea, Republic of
facility: Ulsan University Hospital
city: Wonju-si, Gangwon-do
country: Korea, Republic of
facility: Yonsei University Wonju Severance Christian Hospital
city: Alytus
country: Lithuania
facility: Klinikiniai sprendimai
city: Kaunas
country: Lithuania
facility: Klinikiniai sprendimai
city: Kaunas
country: Lithuania
facility: Saules Seimos Medicinos Centras
city: Klaipeda
country: Lithuania
facility: Kardiologijos ir reabilitacijos klinika
city: Siauliai
country: Lithuania
facility: Pirmoji viltis JSC
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital Santaros Clinic Public Institution
city: Guadalajara
country: Mexico
facility: Virgen Cardiovascular Research SC
state: Jalisco
city: Monterrey
country: Mexico
facility: Eukarya PharmaSite
state: Nuevo León
city: Culiacan
country: Mexico
facility: Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC
state: Sinaloa
city: Xalapa
country: Mexico
facility: Consultorio de Medicina Especializada del Sector Privado
state: Veracruz
city: Aguascalientes
country: Mexico
facility: Centro de investigacion Cardiometabolica
city: Aguascalientes
country: Mexico
facility: Fundacion Cardiovascular de Aguascalientes AC
city: Aguascalientes
country: Mexico
facility: Hospital Cardiologica Aguascalientes
city: Chihuahua
country: Mexico
facility: Scientia Investigacion Clinica SC
city: Ciudad de México
country: Mexico
facility: Procliniq Investigacion Clinica
city: Amersfoort
country: Netherlands
facility: Meander Medisch Centrum
city: Amsterdam
country: Netherlands
facility: Onze Lieve Vrouwe Gasthuis
city: Amsterdam
country: Netherlands
facility: Academisch Medisch Centrum
city: Apeldoorn
country: Netherlands
facility: Gelre Ziekenhuizen
city: Arnhem
country: Netherlands
facility: Rijnstate Ziekenhuis
city: Bergen op Zoom
country: Netherlands
facility: Bravis ziekenhuis, locatie Roosendaal
city: Breda
country: Netherlands
facility: Amphia ziekenhuis
city: Delft
country: Netherlands
facility: Reinier de Graaf Gasthuis
city: Den Haag
country: Netherlands
facility: Haaglanden MC
city: Deventer
country: Netherlands
facility: Deventer Ziekenhuis
city: Eindhoven
country: Netherlands
facility: Catharina Ziekenhuis
city: Eindhoven
country: Netherlands
facility: Maxima Medisch Centrum
city: Enschede
country: Netherlands
facility: Medisch Spectrum Twente
city: Goes
country: Netherlands
facility: Admiraal de Ruyter Ziekenhuis
city: Gouda
country: Netherlands
facility: Groene Hart Ziekenhuis
city: Groningen
country: Netherlands
facility: Martini Ziekenhuis
city: Heerlen
country: Netherlands
facility: Zuyderland Medisch Centrum
city: Hoofddorp
country: Netherlands
facility: Spaarne Gasthuis, locatie Haarlem Zuid
city: Hoorn
country: Netherlands
facility: Dijklander Ziekenhuis Hoorn
city: Leiden
country: Netherlands
facility: Leids Universitair Medisch Centrum
city: Leiderdorp
country: Netherlands
facility: Alrijne Ziekenhuis
city: Nijmegen
country: Netherlands
facility: Radboud Universitair Medisch Centrum
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum
city: Sneek
country: Netherlands
facility: D and A Research and Genetics
city: The Hague
country: Netherlands
facility: Haga Ziekenhuis
city: Tiel
country: Netherlands
facility: Ziekenhuis Rivierenland
city: Tilburg
country: Netherlands
facility: Elisabeth-TweeSteden Ziekenhuis
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum Utrecht
city: Venlo
country: Netherlands
facility: VieCuri Medisch Centrum
city: Oslo
country: Norway
facility: Oslo Universitetssykehus HF Aker sykehus
city: Oslo
country: Norway
facility: Oslo Universitetssykehus HF, Aker sykehus
city: Skedsmokorset
country: Norway
facility: Skedsmo Medisinske senter
city: Belchatow
country: Poland
facility: American Heart of Poland Spolka Akcyjna
city: Bielsko-Biala
country: Poland
facility: American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
city: Chrzanow
country: Poland
facility: American Heart of Poland Spolka Akcyjna
city: Dabrowa Gornicza
country: Poland
facility: American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
city: Gdansk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne
city: Gizycko
country: Poland
facility: NZOZ Medica Jerzy Cygler
city: Kedzierzyn Kozle
country: Poland
facility: American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
city: Krakow
country: Poland
facility: Jaroslaw Ciosek Rajtar-Medica Centrum Medyczne
city: Lodz
country: Poland
facility: Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi
city: Lubin
country: Poland
facility: Miedziowe Centrum Zdrowia SA
city: Lublin
country: Poland
facility: CenterMed Spzoo Centermed Lublin
city: Lublin
country: Poland
facility: Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski
city: Lublin
country: Poland
facility: NZOZ Twoja Przychodnia Spzoo Twoja Przychodnia Spzoo
city: Poznan
country: Poland
facility: Uniwersyteckie Centrum Stomatologii I Medycyny Specjalistycznej Spolka z ograniczona odpowiedzialnos
city: Pulawy
country: Poland
facility: KO-MED Centra Kliniczne Sp zoo KO-MED Centra Kliniczne Pulawy
city: Sztum
country: Poland
facility: American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
city: Tychy
country: Poland
facility: American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
city: Warszawa
country: Poland
facility: FutureMeds Warszawa Centrum
city: Warszawa
country: Poland
facility: Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo
city: Warszawa
country: Poland
facility: Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego - Panstwowy Instytut Badawczy
city: Wroclaw
country: Poland
facility: Futuremeds spolka z ograniczona odpowiedzialnoscia
city: Zabrze
country: Poland
facility: Slaskie Centrum Chorob Serca w Zabrzu
city: Zamosc
country: Poland
facility: KO-MED Centra Kliniczne Zamosc
city: Zgierz
country: Poland
facility: American Heart of Poland Spolka Akcyjna
city: Almada
country: Portugal
facility: Unidade de Saude Local de Almada-Seixal, EPE - Hospital Garcia de Orta
city: Amadora
country: Portugal
facility: Unidade Local de Saude de Amadora-Sintra, EPE
city: Aveiro
country: Portugal
facility: Unidade Local de Saude da Regiao de Aveiro, EPE - Hospital Infante Dom Pedro
city: Braga
country: Portugal
facility: Unidade Local de Saude de Braga, EPE
city: Carnaxide
country: Portugal
facility: Unidade Local de Saude de Lisboa Ocidental, EPE - Hospital de Santa Cruz
city: Cascais
country: Portugal
facility: Hospital de Cascais
city: Coimbra
country: Portugal
facility: Unidade Local de Saude de Coimbra, EPE
city: Guimaraes
country: Portugal
facility: Unidade Local de Saude do Alto Ave, EPE
city: Matosinhos
country: Portugal
facility: Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
city: Porto
country: Portugal
facility: Unidade Local de Saude de Santo Antonio, EPE - Hospital de Santo Antonio
city: Santa Maria da Feira
country: Portugal
facility: Unidade Local de Saude de Entre Douro e Vouga, EPE - Hospital de Sao Sebastiao
city: Setubal
country: Portugal
facility: Unidade Local de Saude da Arrabida, EPE - Hospital de Sao Bernardo
city: Vila Nova de Gaia
country: Portugal
facility: Unidade Local de Saude de Gaia-Espinho, EPE
city: Baia Mare
country: Romania
facility: cmi Cardiologie - Dr Mercea Corina Delia
city: Bucharest
country: Romania
facility: Spitalul Universitar de Urgenta Bucuresti
city: Bucuresti
country: Romania
facility: Spitalul Clinic Universitar de Urgenta Elias
city: Buzau
country: Romania
facility: Matcord Biomedica Buzau
city: Pitesti
country: Romania
facility: SC Sal Med SRL
city: Targu Mures
country: Romania
facility: Cardio Med Medical Center Targu Mures
city: Targu-Mures
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Targu Mures
city: Timisoara
country: Romania
facility: Spitalul Clinic Municipal de Urgenta Timisoara
city: Bardejov
country: Slovakia
facility: Alian, sro
city: Bratislava
country: Slovakia
facility: Narodny ustav srdcovych a cievnych chorob, as
city: Bratislava
country: Slovakia
facility: Kardiovita sro
city: Brezno
country: Slovakia
facility: Nemocnica s poliklinikou Brezno, no
city: Klastor pod Znievom
country: Slovakia
facility: Intergal, sro
city: Kosice
country: Slovakia
facility: Medical group Kosice sro
city: Kosice
country: Slovakia
facility: Zarmed, sro
city: Kosice
country: Slovakia
facility: Cardio D and R, sro Kosice
city: Lucenec
country: Slovakia
facility: Kardio 1 sro
city: Moldava nad Bodvou
country: Slovakia
facility: Medi M and M sro
city: Namestovo
country: Slovakia
facility: Oralek, sro
city: Nitra
country: Slovakia
facility: Kardiocentrum Nitra sro
city: Nove Zamky
country: Slovakia
facility: Kardiomed NZ, sro
city: Presov
country: Slovakia
facility: Medikard, sro
city: Presov
country: Slovakia
facility: Medispol, sro
city: Rimavska Sobota
country: Slovakia
facility: Medilex sro
city: Roznava
country: Slovakia
facility: Tatratrial sro
city: Svidnik
country: Slovakia
facility: Interna SK, sro
city: Trebisov
country: Slovakia
facility: Areteus sro
city: Trencin
country: Slovakia
facility: CardiOr, sro
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia
state: Andalucía
city: Malaga
country: Spain
facility: Hospital Clinico Universitario Virgen de la Victoria
state: Andalucía
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
state: Andalucía
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio
state: Andalucía
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet
state: Aragón
city: Gijon
country: Spain
facility: Hospital de Cabueñes
state: Asturias
city: Leon
country: Spain
facility: Hospital Universitario de Leon
state: Castilla León
city: Badalona
country: Spain
facility: Hospital Universitari Germans Trias i Pujol
state: Cataluña
city: Barcelona
country: Spain
facility: Hospital del Mar
state: Cataluña
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
state: Cataluña
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d Hebron
state: Cataluña
city: Barcelona
country: Spain
facility: Hospital Clinic i Provincial de Barcelona
state: Cataluña
city: Hospitalet de Llobregat
country: Spain
facility: Hospital Universitari de Bellvitge
state: Cataluña
city: Sant Joan Despi
country: Spain
facility: Hospital de Sant Joan Despi Moises Broggi
state: Cataluña
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia
state: Comunidad Valenciana
city: Valencia
country: Spain
facility: Hospital Arnau de Vilanova de Valencia
state: Comunidad Valenciana
city: A Coruña
country: Spain
facility: Complexo Hospitalario Universitario A Coruña
state: Galicia
city: Vigo
country: Spain
facility: Hospital Alvaro Cunqueiro
state: Galicia
city: El Palmar
country: Spain
facility: Hospital Universitario Virgen de la Arrixaca
state: Murcia
city: Madrid
country: Spain
facility: Hospital Universitario Ramon y Cajal
city: Madrid
country: Spain
facility: Hospital Clinico San Carlos
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Falun
country: Sweden
facility: Falu Lasarett
city: Göteborg
country: Sweden
facility: Sahlgrenska Universitetssjukhuset
city: Helsingborg
country: Sweden
facility: Helsingborgs Lasarett
city: Lund
country: Sweden
facility: Clemenstorgets Hjartmottagning
city: Malmo
country: Sweden
facility: PharmaSite Malmo
city: Stockholm
country: Sweden
facility: Karolinska Universitetssjukhuset Huddinge
city: Stockholm
country: Sweden
facility: Karolinska Universitetssjukhuset Solna
city: Hualien
country: Taiwan
facility: Hualien Tzu Chi Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: New Taipei
country: Taiwan
facility: Mackay Memorial Hospital Tamsui Branch
city: Taichung
country: Taiwan
facility: Chung Shan Medical University Hospital
city: Taichung
country: Taiwan
facility: Veterans General Hospital - Taichung
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Shin Kong Wu Ho-Su Memorial Hospital
city: Taoyuan
country: Taiwan
facility: Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
city: Belfast
country: United Kingdom
facility: Ormeau Clinical Trials Ltd
city: Birmingham
country: United Kingdom
facility: Russell Hall Hospital
city: Blackpool
country: United Kingdom
facility: NIHR Patient Recruitment Centre Blackpool
city: Bradford
country: United Kingdom
facility: NIHR Patient Recruitment Centre Bradford
city: Bristol
country: United Kingdom
facility: West Walk Surgery
city: Chichester
country: United Kingdom
facility: St Richards Hospital
city: Chippenham
country: United Kingdom
facility: Rowden Surgery
city: Craigavon
country: United Kingdom
facility: Craigavon Area Hospital
city: Enfield
country: United Kingdom
facility: Panthera Biopartners - London
city: Exeter
country: United Kingdom
facility: NIHR Patient Recruitment Centre Exeter
city: Glasgow
country: United Kingdom
facility: Panthera Biopartners - Glasgow
city: Harefield
country: United Kingdom
facility: Harefield Hospital
city: High Wycombe
country: United Kingdom
facility: Wycombe General Hospital
city: Inverness
country: United Kingdom
facility: Highlands Clinical Research Facility, Raigmore Hospital
city: Leicester
country: United Kingdom
facility: NIHR Patient Recruitment Centre Leicester
city: Lincoln
country: United Kingdom
facility: Lincoln County Hospital
city: London
country: United Kingdom
facility: Queen Mary University of London
city: London
country: United Kingdom
facility: Hammersmith Hospital
city: Penarth
country: United Kingdom
facility: University Hospital Llandough
city: Poole
country: United Kingdom
facility: The Adam Practice
city: Preston
country: United Kingdom
facility: Panthera Biopartners - Preston
city: Stevenage
country: United Kingdom
facility: Lister Hospital
Study officials:
affiliation: Amgen
name: MD
role: STUDY_DIRECTOR
References: