Clinical trial NCT01502384: A Longitudinal Study in 1st Degree Relatives of Parkinson's Disease (PD) Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Parkinson's Disease
Keywords: healthy 1st degree relatives of pd patients
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
Collaborators: name: Beth Israel Medical Center
name: Columbia University
First posted: 2011-12-30
Enrollment: 100
Sex: ALL
Minimum age (years): 35
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy 1ST degree realtives of PD patients

Brief summary: This is a longitudinal study in healthy 1st degree relatives of patients with Parkinson's Disease (PD) carriers of a genetic mutation in genes that are known to increase the risk for PD. The purpose of this study is to explore the association between genetic mutations in the known genes and early preclinical symptoms such as motor, sensory, autonomic, behavioral and cognitive functions.


Eligibility criteria: Inclusion Criteria:

* healthy 1ST degree relatives of PD patients with known genotype that participated in an earlier genetic study at the sourasky medical center.

Exclusion Criteria:

* subjects with cognitive decline by the parameters defined in DSM- IV
* subjects with psychiatric disorder
* subjects unable to sign a consent form

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center
Study officials:
References:
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