louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06724055: Diagnostic Prediction of Pancreatic Masses
Official title: Diagnostic Prediction of Pancreatic Masses: How to Avoid an Unnecessary Resection
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pancreatic Masses
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2024-12-09
Enrollment: 110
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Inpatients in Peking Union Medical College Hospital.

Brief summary: The goal of this observational study is to learn if a strategy can be developed for differentiating autoimmune pancreatitis (AIP) and primary pancreatic lymphoma (PPL) from pancreatic ductal adenocarcinoma (PDAC) in patients presenting with pancreatic masses. The main question it aims to answer is:

What features, in the perspectives of clinical manifestation, laboratory tests, and imaging, can differentiate different kinds of pancreatic masses (AIP, PPL and PDAC)?

Participants will not be given any interventions since this is a retrospective observational study.


Eligibility criteria: Inclusion Criteria:

* Inpatients presenting with pancreatic masses and eventually diagnosed with PPL, AIP, or PDAC (confirmed by pathologic results).

Primary outcomes:
measure: Diagnostic nomogram
timeFrame: From date of admission into the hospital to the establishment of diagnosis, assessed up to 100 months
Secondary outcomes:
measure: serum level of LDH
timeFrame: From date of admission into the hospital to the establishment of diagnosis, assessed up to 100 months
measure: serum level of IgG4
timeFrame: From date of admission into the hospital to the establishment of diagnosis, assessed up to 100 months
measure: largest diameter of pancreatic masses
timeFrame: From date of admission into the hospital to the establishment of diagnosis, assessed up to 100 months
measure: dilation of pancreatic duct
timeFrame: From date of admission into the hospital to the establishment of diagnosis, assessed up to 100 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04866355: Lumbar Spine Manipulation Versus Pharmacological Therapy in Young Women With Primary Dysmenorrhea
Official title: Short-term Effects of Lumbar Spine Manipulation Versus Pharmacological Therapy in Young Women With Primary Dysmenorrhea: a Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Women With Primary Dysmenorrhea
Lead sponsor: University of Alcala
Sponsor class: OTHER
First posted: 2021-04-29
Enrollment: 42
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Many treatments like acupuncture, manipulative therapy and pharmacological therapy have been proposed to alleviate symptoms associated with dysmenorrhea. However, no study has previously compared lumbar spine manipulation to pharmacological therapy in the treatment of primary dysmenorrhea.


Eligibility criteria: Inclusion Criteria:

* Presented with persistent primary dysmenorrhea lasting for three or more consecutive menstrual periods
* Presented menstrual cycles no longer than 35 days

Exclusion Criteria:

* Presented any other gynecological pathologies
* Systemic diseases
* Previous surgical interventions for gynecological complaints
* Depression
* Were receiving any other treatment for primary dysmenorrhea.

Primary outcomes:
measure: Pain intensity
timeFrame: Change from baseline at 3 days
Secondary outcomes:
measure: Pressure pain threshold measured in tibialis malleolus
timeFrame: Change from baseline at 3 days
measure: Pressure pain threshold measured in peroneal malleolus
timeFrame: Change from baseline at 3 days
measure: Low-back related disability
timeFrame: Change from baseline at 1 month
measure: Anxiety and depression
timeFrame: Change from baseline at 1 month
Other outcomes:
Locations:
city: Puebla
country: Mexico
facility: Adelina Jazmin Castillo-Sanchez
city: Alcalá De Henares
country: Spain
facility: Ruben Fernandez-Matias
Study officials:
References:
Clinical trial NCT04716855: Evaluation of Functional Status, Physical Activity and Quality of Life in Patients With Rotator Cuff Syndrome
Official title: Evaluation of Daily Life Activities in Patients With Rotator Cuff Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rotator Cuff Syndrome
Keywords: Pain
Physical activity
Rotator cuff syndrome
Quality of life
Lead sponsor: Istanbul Medipol University Hospital
Sponsor class: OTHER
First posted: 2021-01-20
Enrollment: 40
Sex: ALL
Minimum age (years): 19
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study was applied patients which were diagnosed with RC syndrome the Physical Therapy and Rehabilitation Department at Istanbul Medipol Mega University Hospital.

Brief summary: Pain is one of the most important factors affecting the quality of life. The quality of life of patients with pain and restricted shoulder movements can be affected in patients with Rotator Cuff Syndrome (RCS).

Detailed description: The aim of our study is to examine the effect of the pain on functional status, quality of life and physical activity levels in daily life activities of RCS patients.

Eligibility criteria: Inclusion Criteria:

* Patients presenting with shoulder pain problems and diagnosed with RCS.
* Individuals between the ages of 19-64 were included in the study.

Exclusion Criteria:

* Those who have mental disability at the level of understanding the test and preventing interviews.
* Those with any chronic problems (such as cancer, kidney failure)
* Those who receive special medical treatment (steroid therapy, chemotherapy, insulin use.)
* Those who had a pregnancy status were excluded from the study.

Primary outcomes:
measure: Visual Analog Scale
timeFrame: 2 min
measure: The Shortened Disabilities of the Arm, Shoulder and Hand Score
timeFrame: 10 min
measure: Short Form-36 (SF-36)
timeFrame: 10 min
measure: International Physical Activity Questionnaire (IPAQ)
timeFrame: 10 min
Secondary outcomes:
measure: Manual Muscle Test
timeFrame: 10 min
measure: Range of Motion
timeFrame: 10 min
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Medipol University Hospital
Study officials:
affiliation: Istanbul Medipol University Hospital
name: Mehmet Salih Tan
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06015555: TAMO Therapy Versus Postural Control Exercise in Children With Congenital Muscular Torticollis
Official title: Effect Of Postural Control Exercise Versus¬¬ Tscharnuter Akademie For Motor Organization (TAMO) Therapy On Range Of Motion And Motor Function In Children With Congenital Muscular Torticollis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Torticollis Congenital
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-08-29
Enrollment: 18
Sex: ALL
Minimum age (years): 3
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A randomized control trial was conducted through convenient sampling. 18 subjects were randomly allocated into two groups, group A received postural control exercises in addition to conventional therapy, while Group B received TAMO therapy along with conventional therapy. analysis.

Detailed description: Torticollis is common in children and can be congenital or acquired. Acquired cases can result from neck muscles or bone injuries. Though distressing for parents, it usually improves over time. Treatment includes postural control exercise and TAMO therapy, along with conventional treatment. To compare the effects of TAMO therapy versus postural control exercises on children with congenital muscular torticollis on cervical range of motion. A randomized control trial was conducted through convenient sampling. Eighteen subjects were randomly allocated into two groups; Group A received postural control exercises in addition to conventional therapy, while group B received TAMO therapy along with conventional therapy. The duration of the treatment was eight weeks. Goniometer, still photography, muscle function. Eighteen participants (n=18) were included in the study.

Eligibility criteria: Inclusion Criteria:

* Greater than 3 months
* Both genders
* Abnormal neck posture
* Torticollis of both sides

Exclusion Criteria:

* SCM mass present
* Deficit in cervical PROM greater than 15 degree
* Craniosynostosis (it is a birth defect in which the bones in a baby skull join together too early)
* Infectious
* Metabolic
* Scoliosis of spine
* Developmental plagiocephaly
* SCM tumor
* Visual disorder

Primary outcomes:
measure: Goniometer
timeFrame: Readings were taken at baseline and four months of intervention
measure: Muscle function Scale:
timeFrame: Readings were taken at baseline and four months of intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Riphah Rehabilitation Center, Riphah International University
state: Punjab
Study officials:
References:
Clinical trial NCT00103155: Radiofrequency Ablation in Treating Patients Who Are Undergoing Surgery for Thyroid Cancer
Official title: Radiofrequency Ablation for Low Risk Papillary Thyroid Cancer: A Pilot Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Head and Neck Cancer
Keywords: stage I papillary thyroid cancer
Lead sponsor: National Cancer Institute (NCI)
Sponsor class: NIH
Collaborators: name: National Cancer Institute (NCI)
First posted: 2005-02-08
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: RATIONALE: Radiofrequency ablation uses a high-frequency, electric current to kill tumor cells. Ultrasound-guided radiofrequency ablation may be effective treatment for thyroid cancer.

PURPOSE: This phase I trial is studying the side effects of radiofrequency ablation in treating patients who are undergoing surgery for thyroid cancer.

Detailed description: OBJECTIVES:

* Determine the frequency of complications associated with radiofrequency ablation (RFA) in patients with low-risk papillary thyroid cancer undergoing thyroidectomy.
* Determine the utility of RFA as a treatment option for these patients.

OUTLINE: This is a pilot study.

An electrosurgical probe is placed by ultrasound guidance into the center of the thyroid tumor. Patients undergo radiofrequency ablation directly to the tumor until the target temperature is reached\* for 5 minutes. Patients then undergo standard thyroidectomy.

NOTE: \*Takes approximately 15-30 minutes to reach target temperature.

After completion of study treatment, patients are followed at day 1, between days 14-21, and then periodically as deemed necessary.

PROJECTED ACCRUAL: A total of 15-40 patients will be accrued for this study.

Eligibility criteria: DISEASE CHARACTERISTICS:

* Cytologically confirmed papillary thyroid cancer by fine needle aspiration

  * Low-risk disease
  * No poorly differentiated cytology
* Intrathyroidal tumor

  * Located within the anterior two-thirds of the thyroid lobe
  * Tumor not adjacent to the trachea by neck ultrasound
* Tumor ≤ 1.5 cm by neck ultrasound
* Requires thyroidectomy
* No cervical lymphadenopathy
* No multicentric tumors by neck ultrasound
* No evidence of lymph node metastasis

PATIENT CHARACTERISTICS:

Age

* Over 21

Performance status

* Not specified

Life expectancy

* Not specified

Hematopoietic

* Not specified

Hepatic

* Not specified

Renal

* Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy

* Not specified

Chemotherapy

* Not specified

Endocrine therapy

* Not specified

Radiotherapy

* Not specified

Surgery

* Not specified

Primary outcomes:
measure: Frequency of radiofrequency ablation-associated complications at 2 weeks
Secondary outcomes:
measure: Amount of tumor destruction at 2 weeks
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: UCSF Comprehensive Cancer Center
state: California
Study officials:
affiliation: University of California, San Francisco
name: Electron Kebebew, MD
role: STUDY_CHAIR
References:
Clinical trial NCT01355055: Sympathetic Activity and Renal Denervation
Official title: Influences of Catheter-based Renal Denervation on Central Sympathetic Nervous System Regulation in Refractory Hypertension
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hypertension
Lead sponsor: Hannover Medical School
Sponsor class: OTHER
First posted: 2011-05-17
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with refractory hypertension, in whom catheter-based renal denervation is indicated and who are scheduled for this procedure, will be recruited from the outpatient clinic.

Brief summary: Primary hypothesis:

Catheter-based renal denervation reduces central sympathetic activation in patients with refractory hypertension.

Secondary hypotheses:

1. The magnitude of the individual depressor response after catheter-based renal denervation depends on the extent of sympathoinhibition.
2. Both, the reduction in arterial pressure and in central sympathetic activation are sustained over time up to 24±3 months after catheter-based renal denervation.
3. Catheter-based renal denervation resets the sympathetic baroreflex to lower blood pressure values.


Eligibility criteria: Inclusion Criteria:

* Refractory hypertension (as defined by the WHO: poorly controlled hypertension (\>140/90 mmHg) despite adequate doses of at least three antihypertensive drugs including a diuretic)
* Men or women aged \>18 years
* Intact peroneal nerve
* Written informed consent

Exclusion Criteria:

* Diseases, dysfunctions, or medications (such as NET inhibitors) that exclude a participation in the study according to the investigator.
* Legal incompetence or circumstances that interfere with the patient´s ability to fully understand scope, relevance, and/or consequences of participation in this study.
* People in custody
* hypersensitivity to clonidine, phenylephrine, or nitroprusside-sodium
* sick sinus syndrome, second or third degree AV block, bradycardia \< 50 bpm (contraindication for clonidine)
* endogenous depression (contraindication for clonidine)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Hannover
country: Germany
facility: Hannover Medical School
Study officials:
References:
citation: Brinkmann J, Heusser K, Schmidt BM, Menne J, Klein G, Bauersachs J, Haller H, Sweep FC, Diedrich A, Jordan J, Tank J. Catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to-control hypertensive patients: prospective case series. Hypertension. 2012 Dec;60(6):1485-90. doi: 10.1161/HYPERTENSIONAHA.112.201186. Epub 2012 Oct 8.
Clinical trial NCT05638555: Lactated Ringers vs Normal Saline in Patients With Acute Pancreatitis: A Bias-Adjusted Meta-analysis
Official title: Lactated Ringers vs Normal Saline in Patients With Acute Pancreatitis: A Bias-Adjusted Meta-analysis
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Acute Pancreatitis
Lead sponsor: Qatar University
Sponsor class: OTHER
First posted: 2022-12-06
Enrollment: 500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Adult Patients diagnosed with Acute Pancreatitis (AP)

Brief summary: This study aims to compare NS and LR in terms of outcomes in patients with acute pancreatitis while addressing the current methodological issues with available meta-analyses on the topic. Such comparison combined with bias adjustment will assist with identifying the optimal fluid rehydration therapy in acute pancreatitis, since most of the available data is conflicted around the topic. A database search will be conducted to identify studies comparing normal saline and ringer's lactate. Existing meta-analyses will be assessed. The results will be discussed in the light of their strengths and limitations and then any deficiencies will be addressed through a new synthesis as a final step of this umbrella review. The primary outcome will be SIRS at 24 hours. OR and 95% confidence intervals will be generated using the quality effects model. Heterogeneity will be evaluated using the I2 statistic. Publication bias will be assessed using the Doi Plot.


Eligibility criteria: Inclusion Criteria:

* RCTs and observational studies that compared NS vs LR in AP patients.
* Studies reviewed must report data as effect estimates or provide raw data sufficient to calculate effect estimates.

Exclusion Criteria:

* Studies involving animal studies, pediatric patient populations, and cell lines will be excluded.

All studies will be reviewed in full form by each author to determine eligibility. In case of disagreement, determination of inclusion will be reached via consensus.

Primary outcomes:
measure: Systemic inflammatory response syndrome (SIRS)
timeFrame: at 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Doha
country: Qatar
facility: Suhail Doi
Study officials:
affiliation: Qatar University
name: Suhail Doi
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00294255: Risperidone Plus Mood Stabilizer in Treatment of Mixed Mania
Official title: Risperidone Plus Mood Stabilizer in the Treatment of Mixed Mania
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Bipolar Disorder
Keywords: mixed mania
depression
irritability
Lead sponsor: The University of Texas Health Science Center at San Antonio
Sponsor class: OTHER
Collaborators: name: Janssen, LP
First posted: 2006-02-20
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The study aims to assess the efficacy and tolerability of risperidone added to lithium, valproate or lamotrigine in patients experiencing a manic episode with depressive or irritable features.

Detailed description: * The study aims to assess the efficacy and tolerability of risperidone added to lithium, valproate or lamotrigine, or any combination of the three, in patients experiencing a manic episode with depressive or irritable symptoms.
* To assess the back ground and baseline features associated with response/non-response to risperidone plus mood stabilizer in patients with mania with depressive or irritable features.
* To assess the symptomatic dimensions of response of risperidone added to mood stabilizers in patients with mania with depressive or irritable features.

Eligibility criteria: Inclusion Criteria:

* DSM IV diagnosis of bipolar disorder, currently manic, or mixed manic
* YMRS score\>/= 16
* One or more of following:

  1. 3 MADRS depression items scoring \>/=3
  2. 3 BISS depression items scoring \>/=3
  3. YMRS irritability and aggressive items sum score\>/=4
* Taking lithium, valproate or lamotrigine at stable dose for 4 wks or longer, with adequate serum level
* age 18 and over
* Male or female
* Inpatient or outpatient

Exclusion Criteria:

-

Primary outcomes:
measure: Forty percent reduction in YMRS
timeFrame: 20 weeks
Secondary outcomes:
measure: twenty percent reduction in MADRS
timeFrame: 20 weeks
measure: Remission rate, defined as final score of plus or minus eight on YMRS and MADRS
timeFrame: 20 weeks
Other outcomes:
Locations:
city: San Antonio
country: United States
facility: University of Texas Health Science Center
state: Texas
Study officials:
affiliation: UT-SanAntonio
name: Vivek Singh, MD
role: STUDY_DIRECTOR
affiliation: UT San Antonio
name: Charles Bowden, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01897155: Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.
Official title: Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Hypertensive Disease
Pain, Postoperative
Keywords: analgesia, postoperative;
analgesics opioid;
hyperalgesia;
remifentanil;
hypertension.
Lead sponsor: Pontificia Universidad Catolica de Chile
Sponsor class: OTHER
First posted: 2013-07-11
Enrollment: 50
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this randomized clinical trial is to evaluate the effect of acute arterial hypertension maintained during surgery on morphine's requirements in patients undergoing laparoscopic cholecystectomy

Detailed description: The high arterial blood pressure has been correlated with an increase in pain threshold in animal and humans. One of the explanations to this phenomenon is a baroreceptor activity and vasopressin release at the level of spinal cord dorsal horn and hypothalamus.

As far as we know, there is only one study about the effect of chronic hypertension on postoperative pain and none with acute hypertension. We therefore decided to conduct a randomized controlled trial to evaluate the effect of acute hypertension on postoperative morphine's requirements.

Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiology patient classification status(ASA) I-II
* Between 20 and 60 years of age
* Programed for elective laparoscopic cholecystectomy

Exclusion Criteria:

* History of arterial hypertension
* Baseline blood pressure over 139/89
* Use of opioids and any analgesic drug during the last 24 hours before surgery
* Chronic use of nonsteroidal antiinflammatory
* BMI \> 34.9
* History of drug or alcohol abuse
* Use of medications that interfere in the central nervous system
* Adverse reactions to the drugs used in the study
* Pregnancy

Primary outcomes:
measure: Morphine requirement post laparoscopic cholecystectomy
timeFrame: First 24 hours postoperative
Secondary outcomes:
measure: Effects of acute hypertension in pain scores
timeFrame: First 24 hours postoperative
Other outcomes:
Locations:
city: Santiago
country: Chile
facility: Hospital Clinico Pontificia Universidad Catolica
state: Region Metropolitana
Study officials:
affiliation: Departamento de Anestesiología, Hospital Clínico Pontificia Universidad Católica de Chile
name: Alejandro E Delfino, MD
role: PRINCIPAL_INVESTIGATOR
References: