Clinical trial NCT03893721: Effect of Chronic Arsenic Exposure on Malnutrition of Under Five Children
Official title: Effect of Chronic Arsenic Exposure on Malnutrition Among Under-five Children Attending Assiut University Children Hospital
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Malnutrition, Child
Arsenic Poisoning Chronic
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2019-03-28
Enrollment: 80
Sex: FEMALE
Minimum age (years): 2
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: under five children attending Assiut university Children Hospital

Brief summary: Early life malnutrition is associated with later life health problems, Particularly Stunting, which is a height-for-age Z score less than -2 standard deviation of World Health Organization median.Underweight is weight-for-age Z score less than -2 standard deviation of World Health Organization median. Wasting is weight -for- height Z score less than -2 standard deviation of World Health Organization median.

Detailed description: prevalence of under-five stunting, wasting and underweight are 21% and , 8% and 6% respectively in Egyptian Demographic Health Survey 2014.

The main risk factors for growth restriction in children are maternal under nutrition during pregnancy, lack of exclusive breastfeeding, inappropriate complementary feeding and micronutrient intake and high prevalence of enteric infections. However, other environmental exposures may also play a role in growth restriction .

High concentrations of Arsenic, lead and cadmium in placenta are associated with poor fetal out come and low birth weight. Arsenic crosses the placenta causing suppression of insulin-Like Growth Factor 1.

When breastfeeding is exclusive, infants are unlikely to be exposed to Arsenic by other routes of exposure such as external foods, drinking water and foods made at home using Arsenic contaminated water.

Rational of the study. Improvement of under-five nutritional status is a global target. Although the exposure to arsenic has increased globally, it's impact on nutritional status has seldom been investigated.

Eligibility criteria: Inclusion Criteria:

female children from 2 to 5 years

Exclusion Criteria:

Severely ill children other than severely malnourished.

* Children with congenital anomaly.
* Relatives.

Primary outcomes:
measure: Chronic Arsenic Exposure of Under Five Children
timeFrame: one year
measure: weight measurement
timeFrame: one year
measure: height measurement
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University
Study officials:
affiliation: Assiut University
name: Alyaa Abdelaal, demonstrator
role: PRINCIPAL_INVESTIGATOR
References:
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