Clinical trial NCT06769464: Electrophysiological Representations of Odor in the Human Brain Study 1
Official title: Electrophysiological Representations of Odor in the Human Brain Study 1
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Odor Intensity Ratings
Lead sponsor: Northwestern University
Sponsor class: OTHER
First posted: 2025-01-10
Enrollment: 28
Sex: ALL
Minimum age (years): 12
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Investigating representations of odor intensity in human piriform cortex. To identify a neural representation of perceived odor intensity, it is necessary to dissociate stimulus concentration from perceived intensity. Experiments for this aim will measure human perceptual responses while manipulating intensity independently from concentration using two complementary approaches. In Experiment 1A, we will match perceived intensities across odors of different concentrations, allowing us to identify a neural representation of intensity that is independent of stimulus identity and concentration. In Experiment 1B, we will create conditions of different perceived intensity over constant odor stimuli using adaptation. Approaching the same question from different angles will strengthen the robustness of our findings. Preliminary data suggest that temporal features of the piriform neural response may represent odor intensity.

Detailed description: Olfactory perception relies on the brain's ability to extract and represent different features of an odor stimulus. For example, intensity and identity are fundamental features of the olfactory percept that must be encoded separately for accurate perception; the same odor can be encountered at different strengths. Understanding neural representations of olfactory perceptual features is fundamental to understanding the olfactory system, however the neural correlates of odor intensity and identity are poorly understood in the human brain.

The field of olfaction typically uses chemistry as a proxy for perception and focuses on manipulating physical properties of a stimulus to look for neural correlates. For example, chemical concentration and molecular identity are typically used as proxies for odor intensity and identity. However, the world that animals perceive is not a complete representation of physical reality; it is a product of the particular sensory systems that each species has acquired in the course of evolution. To understand how the brain forms representations of perceptual features of odors, we must identify relationships between features of neural responses and perceptual ratings. While novel behavioral paradigms in rodents can provide good estimates of perceptual ratings of different features of odors (intensity, identity), humans can directly provide perceptual ratings of different features of an odor. Therefore, human work is necessary to fully understand olfactory perception.

The missing link between neural signatures and perceptual properties of odor is a critical gap in our understanding of odor coding. Here, we will combine human intracranial recordings-including direct neural recordings from human olfactory cortex-with simultaneous delivery of precisely controlled odors of varying intensity/identity and trial-by-trial collection of psychophysical ratings to understand how odors are represented in the human brain.

Accurate olfactory psychophysical ratings are a critical part of our proposal. Therefore, we will work with leading experts in human psychophysics at Monel Chemical Senses Center, Dr. Pamela Dalton and Dr. Joel Mainland. As Co-Investigators on this grant, their expertise in human psychophysics will combine with my lab's expertise in human olfactory electrophysiology to provide the field with an understanding of the mappings between olfactory perception and neural codes in the human brain.

Aim 1: Investigating representations of odor intensity in human piriform cortex. To identify a neural representation of perceived odor intensity, it is necessary to dissociate stimulus concentration from perceived intensity. Experiments for this aim will measure human perceptual responses while manipulating intensity independently from concentration using two complementary approaches. In Experiment 1A, we will match perceived intensities across odors of different concentrations, allowing us to identify a neural representation of intensity that is independent of stimulus identity and concentration. In Experiment 1B, we will create conditions of different perceived intensity over constant odor stimuli using adaptation. Approaching the same question from different angles will strengthen the robustness of our findings. Preliminary data suggest that temporal features of the piriform neural response may represent odor intensity.

Eligibility criteria: Inclusion Criteria:

* Ages 12 to 65, english speaker, patients undergoing brain surgery for treatment of medically intractable epilepsy

Exclusion Criteria:

* screening for history of smell or taste problems

Primary outcomes:
measure: Perceived odor intensity
timeFrame: 15 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Northwestern University
state: Illinois
Study officials:
affiliation: Northwestern University
name: christina zelano
role: PRINCIPAL_INVESTIGATOR
References: