louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05162079: Protocol for the ESREFLUJO Study: Epidemiological Study of Heartburn and Gastroesophageal Reflux in Community Pharmacy
Official title: Protocol for the ESREFLUJO Study: Epidemiological Study of Heartburn and Gastroesophageal Reflux in Community Pharmacy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Reflux
Keywords: HEARTBURN, DYSPEPSIA, REFLUX, PHARMACY
Lead sponsor: Universidad Miguel Hernandez de Elche
Sponsor class: OTHER
First posted: 2021-12-17
Enrollment: 1200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Spanish patients who visit the pharmacies asking for advice of acid-reflux symptoms or requesting non-prescription medication for it

Brief summary: Introduction: Symptoms as heartburn and/or reflux is frequent consultations in community pharmacies, the characterization of them is crucial to provide appropriate patient counseling. To facilitate the assistance work of the community pharmacist and its coordination between different levels of care, a group of experts in Community Pharmacy, Primary Care, and Gastroenterology has recently worked on an algorithm to manage these symptoms.

Objective: Analyse the epidemiological characteristics of patients who consult for symptoms of heartburn and/or reflux in Spanish community pharmacies, and evaluate the clinical and humanistic results of the protocolization of a Professional Pharmaceutical Service in said patients.

Methods and analysis: The study design consists of a cross-sectional descriptive part, in which the clinical and sociodemographic characteristics of the patients who come to the community pharmacy will be evaluated for consultation derived from heartburn and/or reflux symptoms and a before-after descriptive study in which will evaluate the clinical and humanistic results in patients who come to the pharmacy after receiving pharmaceutical care.


Eligibility criteria: Inclusion Criteria:

* Population´s age ≥ 18 years
* Patients who consult for mild symptoms of heartburn and/or gastroesophageal reflux or request treatment for it.

Exclusion Criteria:

* Subjects who request treatment for symptoms of heartburn and/or gastroesophageal reflux for another person
* Women with high-risk pregnancies

Primary outcomes:
measure: Collection of sociodemographic data of participants
timeFrame: 8 minutes each questionnaire
measure: Collection of clinical data of participants
timeFrame: 8 minutes each questionnaire
measure: Detail the evolution of the patient's symptoms 14 days after intervention
timeFrame: 5 minutes
measure: Evaluate patient satisfaction
timeFrame: 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Lopez-Pintor E, Puig-Molto M, Lumbreras B. EsReflux Protocol: Epidemiological Study of Heartburn and Reflux-like Symptoms in Spanish Community Pharmacies. Int J Environ Res Public Health. 2022 Aug 9;19(16):9807. doi: 10.3390/ijerph19169807.
Clinical trial NCT04487379: Ultrasound Crestal Bone Topography of Edentulous Ridges
Official title: Evaluation of Crestal Bone Topography of Edentulous Ridges: A Retrospective Study Comparing Ultrasonography to Cone-Beam Computed Tomography (CBCT)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ultrasonography
Lead sponsor: University of Michigan
Sponsor class: OTHER
First posted: 2020-07-27
Enrollment: 28
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Records of patients who had at least 1 edentulous ridge with a plan for implant placement, had cone-beam computed tomography as standard procedure and ultrasound imaging for off-label use of evaluating the ridge were included.

Brief summary: A successful implant surgery primarily relies on a prudent evaluation of oral anatomy and meticulous treatment planning. Additionally, of paramount importance that dictates the types of procedures, material selection and ultimately success of implant surgery is the quality and quantity of the edentulous ridge. Ultrasound imaging (US), another cross-sectional imaging modality, has been extensively used in the medical diagnostics field. The ability of ultrasound to image soft tissue-bone interface makes it particularly promising for studying bone ridge width and crestal bone topography. Therefore, this retrospective human study aimed to compare bone width measurements between US and CBCT. This study also investigated the possible correlation between the crestal bone surface quality imaged by US and CBCT.


Eligibility criteria: Inclusion Criteria:

* Patient records at the Graduate Periodontal Clinic
* With both US and CBCT scans taking within 3 months between each other from Jan 2016 to Mar 2020
* These images had to include at least one edentulous ridge at the anterior, premolar or molar site.
* Multiple sites in a given patient may be included.

Primary outcomes:
measure: Accuracy of ultrasound for estimating ridge width
timeFrame: up to 3 months after image was taken
Secondary outcomes:
measure: Accuracy of ultrasound for assessing ridge surface quality
timeFrame: up to 3 months after image was taken
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan School of Dentistry
state: Michigan
Study officials:
References:
Clinical trial NCT03946579: Quality of Life and Sexuality of Patients Over 65 Years Undergoing Adjuvant Treatment for Breast Cancer
Official title: Evaluation of the Quality of Life and Sexuality of Patients Over 65 Years of Age Undergoing Adjuvant Treatment for Breast Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Breast Cancer
Keywords: sexual health
quality of life
adjuvant chemotherapy
Lead sponsor: Centre Henri Becquerel
Sponsor class: OTHER
First posted: 2019-05-10
Enrollment: 14
Sex: FEMALE
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The purpose of this study is to assess the quality of life and sexuality during adjuvant chemotherapy in over 65 years old patients with breast cancer

Detailed description: Evaluation of quality of life and sexual health will be assessed by the mean of validated self questionnaires after surgery for breast cancer, before and after adjuvant chemotherapy and one year after initial surgery

Eligibility criteria: Inclusion Criteria:

* Women over 65 years of age
* treatment by adjuvant therapy for breast cancer
* pTxNxM0
* sexually active at least three months before inclusion
* in couple or not

Exclusion Criteria:

* Inflammatory breast cancer
* Not sexually active before breast cancer diagnosis
* Opposition to fill sel questionnaire and collection of the data

Primary outcomes:
measure: Assessment of Sexual Health
timeFrame: one year
Secondary outcomes:
measure: Assessment of Quality of life
timeFrame: one year
measure: Assessment of Body Image
timeFrame: one year
measure: Assessment ofTiredness
timeFrame: one year
measure: Assessment of Anxiety
timeFrame: one year
measure: Assessment of Depression
timeFrame: one year
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens
city: Caen
country: France
facility: Centre François Baclesse
city: Rouen
country: France
facility: Centre Henri Becquerel
Study officials:
affiliation: Centre Henri Becquerel
name: Olivier Rigal, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01356979: Outcome of Patients Undiagnosed Under Medical Thoracoscopy
Official title: Outcome of Patients Who Could Not Have Been Diagnosed by Medical Thoracoscopy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pleural Diseases
Keywords: Medical thoracoscopy
Pleural effusion
Malignant pleural diseases
Tuberculous pleuritis
Fibrinous pleuritis
Lead sponsor: Eskisehir Osmangazi University
Sponsor class: OTHER
First posted: 2011-05-20
Enrollment: 355
Sex: ALL
Minimum age (years): 20
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The patients with undiagnosed exudative pelural effusion by clinical, radiological or laboratory investigations.

Brief summary: Medical thoracoscopy (MT) under local anaesthetic and mild sedation, an established method in the diagnosis of pleural diseases. MT has an overall diagnostic yield above 90% for malignant pleural diseases and pleural tuberculosis. However, others who are diagnosed as fibrinous pleuritis make confusion in clinicians. Whether these patients are firmly followed or not ? The investigators do not know the answer of this question.

In this study the investigators aimed to investigate the outcome of the patients who are diagnosed as fibrinous pleuritis on MT biopsies.

Detailed description: Medical thoracoscopy (MT) under local anaesthetic and mild sedation, an established method in the diagnosis of pleural diseases with a sensitivity above 90% and specificity of 1000% for malignant pleural diseases and pleural tuberculosis. Except these two groups of patients, in others pleural histopathological diagnosis is defined as "non-specific pleuritis" or "fibrinous pleuritis". Authors say that the natural evolution of these patients is poorly understood. Some of these patients was later established false negative cases for malignant pleural diseases. Clinical guidelines recommend close observation of patients with undiagnosed exudative effusions, although the length and follow-up regime is not defined, yet. In this study the investigators examine the outcome of patients who are diagnosed as fibrinous pleuritis by MT.

Eligibility criteria: Inclusion Criteria:

* Undiagnosed exudative pleural effusion
* Under 20 years-old, over 85 years-old
* Followed 2 years at least

Exclusion Criteria:

* Transudative pleural effusion
* Patients who do not accepted medical thoracoscopy.

Primary outcomes:
measure: Accuracy of medical thoracoscopy for patients diagnosed as fibrinous pleuritis.
timeFrame: 2 years
Secondary outcomes:
measure: To determine the factors which point the false positive diagnosis of fibrinous pleuritis.
timeFrame: 2 years
Other outcomes:
Locations:
city: Eskisehir
country: Turkey
facility: ESOGU Medical Faculty Department of Chest Diseases
state: Meselik - Eskisehir
Study officials:
affiliation: ESOGU Medical Faculty Department of Chest Diseases
name: Muzaffer Metintas, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02552979: Atopy Patch Test in Children With Atopic Dermatitis
Official title: Atopy Patch Test in Children With Atopic Dermatitis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Atopic Dermatitis
Food Allergy
Keywords: atopic dermatitis
atopic patch test
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2015-09-17
Enrollment: 56
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: children with atopic dermatitis

Brief summary: Positive reactions in atopy patch test in children with atopic dermatitis.

Detailed description: The prevalence of food allergy seems to be increasing, which might explain the increased demand for reliable evaluation of patients with suspected food-related gastrointestinal symptoms. Little is known about the diagnostic accuracy of atopy patch tests(APT) in the clinical practice. APT seems to have a better specificity than the IgE methods and seems to reflect late-phase clinical reactions.The aims of this study were to evaluate:

(i) The prevalence of positive reaction of APTs for atopic dermatitis (ii)Positive reaction of APT compare with skin prick test. (iii)Positive reaction of APT using lyophilized food vs commercially available food extracts. (iv)Side effect or adverse

Eligibility criteria: Inclusion Criteria:

* Patients who had history of atopic dermatitis

Exclusion Criteria:

* Who have dermographism
* Who have chronic disease eg. autoimmune disease, immune deficiency, cancer or allergic disease
* Pregnant women
* Who receive antihistamine, topical steroid and systemic steroid \> 20 mg/day within 7 days prior study

Primary outcomes:
measure: atopic patch test in atopic dermatitis children
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01232179: Comparison of Two Laser Therapy Methods for PDR
Official title: Comparison Between Result and Side Effects of Treatment of Prolifrative Diabetic Retinopaty by Conventional and Extended Targeted Pan Retinal Photocoagolation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Proiriftrative Diabetic Retinopathy
Lead sponsor: Shahid Beheshti University of Medical Sciences
Sponsor class: OTHER
First posted: 2010-11-02
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Primary purpose: TREATMENT

Brief summary: Proliferative diabetic retinopathy (PDR) is treated with conventional pan retinal photocoagulation (PRP) which can improve the visual prognosis in this complication significantly. However , the treatment may also resulting adverse effects such as blurring of central vision, visual field constriction and disturbance in dark adaptation and contrast vision. Extended targeted retinal coagulation (TRP) to the ischemic areas may cause regression of the neovascularization while minimizing some of the risks and complication associated of treatment of PDR with these two methods.


Eligibility criteria: Inclusion Criteria:

* patients with PDR condidate for photocoagulation teraphy
* Pupil with dilatasion≥6mm
* without privious treatment with anti VEGF drugs 3months before study
* without privious vitroretinal sugery
* without privoius lasertraphy

Exclusion Criteria:

* To have NVI cricteria with increase of inraocular pressure
* to have cataract or vitrus leakage which prevent lasertraphy
* pupil smaller that 6mm
* traditional retinal detachment
* privious treatment with anti VEGF drugs 3months before study
* privious PRP
* patient unable to get wide field FAG

Primary outcomes:
measure: no leakage in widefield fluorescin angiography
timeFrame: 3 months after lasertraphy
Secondary outcomes:
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Labbafinejad medical center
Study officials:
References:
citation: Nikkhah H, Ghazi H, Razzaghi MR, Karimi S, Ramezani A, Soheilian M. Extended targeted retinal photocoagulation versus conventional pan-retinal photocoagulation for proliferative diabetic retinopathy in a randomized clinical trial. Int Ophthalmol. 2018 Feb;38(1):313-321. doi: 10.1007/s10792-017-0469-7. Epub 2017 Feb 6.
Clinical trial NCT02014779: Internet-Based Relapse Prevention vs Face to Face Therapy at an Employee Assistance Program
Official title: Internet-Based Relapse Prevention With Therapist Support vs Face to Face Therapy at an Employee Assistance Program: A Randomized Controlled Non-inferiority Trial
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Alcohol Abuse
Alcohol Addiction
Keywords: Randomized Controlled Trial
Alcohol
Internet
Internet based therapy
Cognitive behavioral therapy
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
First posted: 2013-12-18
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objectives: This study will evaluate the efficacy of internet-based relapse prevention with therapist support, as compared to face-to-face therapy at an employee assistance program. The design is a two-armed randomized controlled design, and outcomes are measured in terms of changes in problematic alcohol use, as well as depression and quality of life.

Method: Participants with problematic alcohol use who, after an initial evaluation consisting of five face-to-face sessions with a licensed psychologist where alcohol and collateral problems are extensively assessed, are recommended treatment for problematic alcohol use. Consenting participants will be randomized into one of two groups: 1. Internet delivered relapse prevention with therapist support or 2. Face-to-face therapy. Outcomes on alcohol use, depression and quality of life as well as information on user satisfaction will be gathered post treatment. Follow up will be at 3, 6 and 12 months after completion.

Our hypothesis is that the internet-based program with therapist support and the face-to-face therapy will be equally effective in reducing alcohol use (non-inferiority).


Eligibility criteria: Inclusion Criteria:

Problematic alcohol use and having been recommended psychotherapy by the assessing psychologist.

Exclusion Criteria:

Inadequate Swedish language skills No Internet access Reading and/or writing difficulties Major depression Current suicidal thoughts and/or plans Primary problematic drug use PTSD-related problems Psychosis Cognitive disability

Primary outcomes:
measure: Alcohol Use Identification Test (AUDIT)
timeFrame: Post, 3, 6 and 12 months
Secondary outcomes:
measure: Time Line Follow Back (TLFB)
timeFrame: Post, 3, 6 and 12 months
measure: Montgomery Asberg Depression Rating Scale - Self report (MADRS-S)
timeFrame: Post, 3, 6 and 12 months
measure: World Health Quality of Life Scale (WHOQOL-BREF)
timeFrame: Post, 3, 6 and 12 months
Other outcomes:
measure: Drug Use Identification Test (DUDIT)
timeFrame: Post, 3, 6 and 12 months
measure: Biological tests for alcohol markers
timeFrame: Post
Locations:
city: Stockholm
country: Sweden
facility: Karolinska institutet, Department of Clinical Neuroscience
Study officials:
affiliation: Karolinska Institutet
name: Anne H Berman, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02172079: Mobilization With Movement for Shoulder Impingement
Official title: Effects of Mobilization-with-Movement on Pain and Range of Motion in Unilateral Shoulder Impingement Syndrome: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Shoulder Impingement Syndrome
Keywords: shoulder impingement, manual therapy, pain, motion.
Lead sponsor: Universidad Rey Juan Carlos
Sponsor class: OTHER
Collaborators: name: University of Salamanca
First posted: 2014-06-24
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Controversy exists regarding the effectiveness of manual therapy techniques for the management of impingement syndrome. However, no adequately powered clinical trials have examined the effects of mobilization-with-movement. The purpose of the current study was to perform a randomized controlled trial comparing the effects of real MWM to a group receiving a sham intervention on shoulder pain at different moments and active shoulder range of motion in an adequately powered sample of patients with shoulder impingement syndrome.


Eligibility criteria: Inclusion Criteria:

* history of shoulder pain of \> 3months duration
* pain localized at the proximal anterolateral shoulder region
* medical diagnosis of shoulder impingement syndrome
* at least 2 positive impingement tests including Neer, Hawking, or Jobe test

Exclusion Criteria:

* diagnosis of fibromyalgia
* pregnancy
* a history of traumatic onset of shoulder pain
* other histories of shoulder injury
* ligamentous laxity based on a positive Sulcus test and apprehension test
* numbness or tingling in the upper extremity
* previous shoulder or cervical spine surgery
* corticosteroid injection on the shoulder within 1 year of the study
* physical therapy 6 months prior to the study

Primary outcomes:
measure: Changes in the intensity of shoulder pain before and after the treatment
timeFrame: Baseline and one week after intervention
Secondary outcomes:
measure: Changes in shoulder range of motion before and after the treatment
timeFrame: Baseline and one week after the intervention
Other outcomes:
Locations:
city: Salamanca
country: Spain
facility: Francisco Alburquerque Sendín
Study officials:
affiliation: University of Salamanca
name: Francisco Alburquerque Sendín, PT, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Universidad Rey Juan Carlos
name: César Fernández de las Peñas, PT, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT06554379: The Effect of Periodontal Health on Smile
Official title: Investigation of the Effect of Periodontal Health on Smile Parameters: a Cross-Sectional
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Smiling
Gingival Diseases
Keywords: gingivitis
periodontal health
smile
Lead sponsor: Abant Izzet Baysal University
Sponsor class: OTHER
First posted: 2024-08-15
Enrollment: 108
Sex: ALL
Minimum age (years): 18
Maximum age (years): 33
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: 108 systemically healthy individuals between 13 and 33 years of age

Brief summary: Anamnesis was taken from 108 patients aged 18-33 who applied to the clinic and met the inclusion criteria. Photographs of the patients' smiles were taken without any measurement. Plaque , gingival index , bleeding on probing, pocket depth measurements, clinical attachment, and gingival recession levels were measured, respectively. Patients were divided into two groups: peri-implant health and gingivitis. Gingival thickness and keratinized gingival width were also measured. In addition, the smile aesthetic index, style, type, and stage were also determined using the smile classification system. Gingival visibility was measured in mm from the photographs taken.


Eligibility criteria: Inclusion Criteria:

* No systemic disease

Exclusion Criteria:

* Active smoking,
* Ongoing or past orthodontic treatment,
* Pregnancy,
* Nursing,
* Individuals who have drug-induced gingival hyperplasia, hereditary gingival fibromatosis, permanent or removable prostheses in the upper front area, or missing teeth in the front region

Primary outcomes:
measure: Keratinized gingival thickness
timeFrame: Baseline
measure: Keratinized gingival width
timeFrame: Baseline
measure: Gingival display
timeFrame: Baseline
measure: Smile esthetic index
timeFrame: Baseline
measure: Smile clasificatain system
timeFrame: Baseline
measure: Gingival phenotype
timeFrame: Baseline
Secondary outcomes:
measure: Plaque index
timeFrame: Baseline
measure: Gingival index
timeFrame: Baseline
measure: Bleeding on probing
timeFrame: Baseline
measure: Periodontal pocket depth
timeFrame: Baseline
measure: Clinical attachment level
timeFrame: Baseline
measure: Gingival recession depth
timeFrame: Baseline
Other outcomes:
Locations:
city: Bolu
country: Turkey
facility: Bolu Abant İzzet Baysal University
Study officials:
References: