Clinical trial NCT01477164: Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
Official title: Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sarcopenia
Keywords: Exercise
Aging
Sarcopenia
Muscle function
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2011-11-22
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect changes with aging or type of exercise. The investigators will determine the ability for endurance, resistance, or a combination of exercise training to remove older-damaged proteins and make newer-functional muscle proteins in groups of younger and older people. The investigators will particularly study protein that are involved with energy production (mitochondrial proteins) and force production (contractile proteins).

Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger people.

Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile and mitochondrial proteins in younger and older people.

Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of contractile proteins in younger and older people.

Detailed description: The loss of muscle mass and function with age leads to high social and economic costs. Lifestyle interventions that can help maintain muscle mass and function can be beneficial to improve health and decrease the costs associated with loss of independence in the elderly. Muscle proteins accumulate damage during aging, which is suggested to lead to loss of function. The biological processes that remove damaged proteins and synthesis new proteins appear to be decreased with aging. Exercise is known to increase the processes that remove older and synthesis newer muscle proteins and may be an effect lifestyle intervention to improve muscle quality and function. Additionally, specific types of proteins appear to decay with age including contractile and mitochondrial proteins. Different types of exercise training can increase the making of specific proteins. The investigators will examine the ability for aerobic and resistance training to increase the quality of mitochondrial and contractile proteins between younger and older people.

Eligibility criteria: Inclusion Criteria:

* Healthy
* 18 to 30 years or 65 to 80 years old
* Male and female

Exclusion Criteria:

* Regular exercise program
* Smoking
* Metabolic disease (diabetes, cardiovascular disease, cancer, thyroid disorders)
* Pregnancy
* Inability to exercise
* Overweight or obesity
* Drugs known to impair metabolic function (statin, beta-blocker, anti-inflammatory)
* Allergies to lidocaine

Primary outcomes:
measure: Skeletal muscle protein synthesis rate
timeFrame: Approximately 14 weeks for the endurance or resistance training groups and approximately 28 weeks for the combined group
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: K. Sreekumaran Nair, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: