Clinical trial NCT05589779: Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling.
Official title: Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Asthma
Cardiovascular Diseases
Keywords: Asthma
Cardiovascular Diseases
Chronic inflammation
Bronchial remodeling
Eosinophilia
Lead sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Sponsor class: OTHER
First posted: 2022-10-21
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Asthmatic patients with and without cardiovascular disease

Brief summary: To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease.

Detailed description: Recent studies have shown that asthma could be a risk factor for cardiovascular disease, especially in the female and late-onset subgroups. The two entities share several risk factors, such as chronic inflammation and bronchial remodeling. Eosinophilia, characteristic of asthma, has also been described as a predictor of cardiovascular mortality.

The aim of this study is to determine the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.

Eligibility criteria: Inclusion Criteria:

* Previous diagnosis of asthma
* Signed informed consent

Exclusion Criteria:

* Age under 18 years old
* Age over 99 years old
* Pneumological diseases other than asthma
* Active oncological diseases or with end of treatment \<5 years
* Autoimmune or systemic inflammatory diseases

Primary outcomes:
measure: Clinical characteristics of patients with asthma
timeFrame: 1 year
measure: Associated cardiovascular disease type
timeFrame: 1 year
Secondary outcomes:
measure: Eosinophil subtypes
timeFrame: 1 year
measure: Biomarkers of chronic inflammation
timeFrame: 1 year
measure: Bronchial remodeling
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
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