Clinical trial NCT03194243: Pathway and Urgent caRe of Dyspneic Patient at the Emergency Department in LorrainE District (PURPLE)
Official title: Pathway and Urgent caRe of Dyspneic Patient at the Emergency Department in LorrainE District
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Dyspnea
Keywords: acute dyspnea
acute heart failure
emergency
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2017-06-21
Enrollment: 75000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with acute dyspnea and treated in an emergency department of the participating centers in the Lorraine district.

Brief summary: This is an observational prospective multicenter study of patients admitted for acute dyspnea in an emergency department of the participating centers in the Lorraine district.

The primary objective is to assess the outcome of this population according to the cause of acute dyspnea as well as identify the predictors of this outcome, both overall and according to each acute dyspnea cause.

Detailed description: This observational prospective multicenter study will be conducted using data from electronic medical records, acquired as part of usual care, in patients admitted for acute dyspnea in the emergency department. Clinical, treatment, laboratory and imaging data acquired during the hospitalization (in the emergency department and in the department that admitted the patients following the emergency department stay) will be collected.

Vital status will be recorded at 30 days and 1 year post-admission.

Eligibility criteria: Inclusion Criteria:

* Men or women \> or = 18 years.
* Patients with acute dyspnea admitted for acute dyspnea in the emergency department.
* Patient informed.

Exclusion Criteria:

* Cardiorespiratory arrest.
* Patient having expressed his or her opposition.

Primary outcomes:
measure: All cause mortality
timeFrame: From emergency admission for acute dyspnea up until 1 year
Secondary outcomes:
measure: Demographic data
timeFrame: through hospital stay, an average of 10 days
measure: Clinical data
timeFrame: through hospital stay, an average of 10 days
measure: Treatment data
timeFrame: through hospital stay, an average of 10 days
measure: Laboratory data
timeFrame: through hospital stay, an average of 10 days
measure: Imaging data
timeFrame: through hospital stay, an average of 10 days
measure: Duration of hospitalization
timeFrame: At final discharge, an average of 10 days after admission
measure: Initial diagnosis in the emergency department
timeFrame: At admission
measure: Final diagnosis of the initial hospitalization stay
timeFrame: At final discharge, an average of 10 days after admission
measure: Brain Natriuretic Peptide
timeFrame: Through hospital stay, an average of 10 days
measure: Estimated glomerular function rate
timeFrame: Through hospital stay, an average of 10 days
measure: Estimated plasma volume
timeFrame: Through hospital stay, an average of 10 days
measure: Liver biological biomarkers
timeFrame: Through hospital stay, an average of 10 days
measure: Urea
timeFrame: Through hospital stay, an average of 10 days
measure: Use of non-invasive ventilation
timeFrame: Through hospital stay, an average of 10 days
measure: Time of use of non-invasive ventilation
timeFrame: Through hospital stay, an average of 10 days
measure: Use of diuretics
timeFrame: Through hospital stay, an average of 10 days
measure: Time of use of diuretics
timeFrame: Through hospital stay, an average of 10 days
measure: Use of nitrates
timeFrame: Through hospital stay, an average of 10 days
measure: Time of use of nitrates
timeFrame: Through hospital stay, an average of 10 days
measure: Department type admitting the patient following emergency management
timeFrame: Through hospital stay, an average of 10 days
measure: All cause in-hospital mortality
timeFrame: At final discharge, an average of 10 days after admission
Other outcomes:
Locations:
city: Forbach
country: France
facility: CH Marie-Madeleine FORBACH - Service des Urgences
state: Lorraine
city: Lunéville
country: France
facility: CH LUNEVILLE - Service des Urgences
state: Lorraine
city: Metz
country: France
facility: CHR METZ-THIONVILLE- Hôpital de Mercy- Service des Urgences
state: Lorraine
city: Nancy
country: France
facility: CHRU Nancy - Service des Urgences
state: Lorraine
city: Pont-à-Mousson
country: France
facility: CH PONT A MOUSSON- Service des Urgences
state: Lorraine
city: Remiremont
country: France
facility: CH REMIREMONT - Service des Urgences
state: Lorraine
city: Saint-Dié-des-Vosges
country: France
facility: CH SAINT-DIE-DES-VOSGES - Service des Urgences
state: Lorraine
city: Thionville
country: France
facility: CHR METZ-THIONVILLE- Hôpital Bel-Air- Service des Urgences
state: Lorraine
city: Épinal
country: France
facility: CH EPINAL - Service des Urgences
state: Lorraine
Study officials:
affiliation: Central Hospital, Nancy, France
name: Tahar CHOUIHED, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Central Hospital, Nancy, France
name: Nicolas GIRERD, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Buessler A, Chouihed T, Duarte K, Bassand A, Huot-Marchand M, Gottwalles Y, Penine A, Andre E, Nace L, Jaeger D, Kobayashi M, Coiro S, Rossignol P, Girerd N. Accuracy of Several Lung Ultrasound Methods for the Diagnosis of Acute Heart Failure in the ED: A Multicenter Prospective Study. Chest. 2020 Jan;157(1):99-110. doi: 10.1016/j.chest.2019.07.017. Epub 2019 Aug 2.