Clinical trial NCT01059968: Low Energy Availability, Menstrual Irregularity, and Low Bone Mass
Official title: The Role of Low Energy Availability and the H-P-A Axis, Menstrual Irregularity, and Low Bone Mass
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bone Density
Energy Availability
Keywords: bone density
energy availability
menstrual status
female
adolescent
Lead sponsor: USDA, Western Human Nutrition Research Center
Sponsor class: FED
Collaborators: name: San Diego State University
First posted: 2010-02-01
Enrollment: 45
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: adolescent female cross country runners

Brief summary: This study examines the role of energy availability on menstrual function and bone mass in female adolescent endurance athletes. Specific evaluations include dietary intake, exercise energy expenditure, training schedules, menstrual function and bone density.

Detailed description: The purpose of this project is to examine the relationships among low energy availability, H-P-A axis, menstrual function and bone density and bone turnover in high school female cross country runners. Our objectives are to: 1)determine energy intake, exercise energy expenditure, and fat-free mass to examine energy availability; 2)in a subset of runners, using double labelled water, estimate total energy expenditure and indirect calorimetry to estimate resting metabolic rate; 3)assess the relationship between energy availability, hormones that regulate bone turnover, markers of bone formation and resorption and bone mineral content and density; 4)identify the relationship between energy availability, hormones that regulate menstrual function and current menstrual status; and 5)determine the energy intake and energy expenditure variables exhibiting the strongest associations with energy availability.

Eligibility criteria: Inclusion Criteria:

* high school female cross country runners
* ages 15-17 years
* 1-5 years experience as cross country runner
* 25 miles or more/week training

Exclusion Criteria:

* medications known to affect bone metabolism
* pregnancy

Primary outcomes:
measure: Bone density
timeFrame: 3 months
Secondary outcomes:
measure: Energy availability
timeFrame: 3 months
Other outcomes:
Locations:
city: Davis
country: United States
facility: Marta Van Loan
state: California
Study officials:
affiliation: USDA, ARS, Western Human Nutrition Research Center
name: Marta D Van Loan, Ph.D.
role: STUDY_CHAIR
References:
citation: Wood KL, Barrack MT, Gray VB, Cotter JA, Van Loan MD, Rauh MJ, McGowan R, Nichols JF. Cognitive dietary restraint score is associated with lower energy, carbohydrate, fat, and grain intake among female adolescent endurance runners. Eat Behav. 2021 Jan;40:101460. doi: 10.1016/j.eatbeh.2020.101460. Epub 2020 Nov 25.
citation: Barrack MT, Van Loan MD, Rauh MJ, Nichols JF. Physiologic and behavioral indicators of energy deficiency in female adolescent runners with elevated bone turnover. Am J Clin Nutr. 2010 Sep;92(3):652-9. doi: 10.3945/ajcn.2009.28926. Epub 2010 Jul 7.