louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04346784: The Effect of Emotional Working Memory Training on Preventing Depression Occurrence
Official title: A Randomized, Double-blind, Placebo-Controlled Evaluation of the Efficacy of Emotional Working Memory Training in the Prevention Treatment of Depressive Symptoms
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Depressive Symptoms
Keywords: Depression
Cognitive control
Emotion
Working memory
Cognitive bias
Emotional regulation
Lead sponsor: Hunan Normal University
Sponsor class: OTHER
First posted: 2020-04-15
Enrollment: 110
Sex: ALL
Minimum age (years): 16
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to test whether emotional working memory training and attention bias modification training are an effective neurobehavioral therapy to prevent the occurrence of depression .That is whether emotional working memory training and attention bias modification training are superior to placebo in preventing the occurrence of depression over 1 year after training.

Detailed description: Attentional bias has been theorized to play a critical role in the onset and maintenance of depression. Attentional bias modification training (ABMT), an experimental paradigm that uses training to induce adaptive attentional bias, was developed to test the causal model and this has therapeutic implications in depression.To test the effect of ABMT on treatment of depressive symptoms, a randomized, double-blind, placebo and blank controlled trial is conducted in college students who are experiencing mild-to-severe symptoms of depression.

Eligibility criteria: Inclusion Criteria:

* A score of 14 or higher on the Beck Depression Inventory-II.

Exclusion Criteria:

* A current episode of MDD, bipolar disorder, schizophrenia or organic mental disorder;
* Any concurrent psychotherapy;
* Any concurrent psychotropic medication.

Primary outcomes:
measure: Changes of depressive symptoms
timeFrame: pre-training, post-training(2 weeks after pre-training), follow-ups(1-week,2-week,4-week,7-week,3-month( booster pre-training), 4-month (booster post-training), 5-month,6-month,12-month after post-training)
Secondary outcomes:
measure: Changes of self-reported depressive symptoms
timeFrame: pre-training, post-training(2 weeks after pre-training), follow-ups(1-week,2-week,4-week,7-week,3-month( booster pre-training), 4-month (booster post-training), 5-month,6-month,12-month after post-training)
Other outcomes:
Locations:
city: Changsha
country: China
facility: Department of Psychology, Hunan Normal University
state: Hunan
Study officials:
affiliation: Department of Psychology, Hunan Normal University
name: Wenhui Yang, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03811184: Validation of a Smartphone Application for the Assessment of Patients With Mild Cognitive Impairment: MemScreen
Official title: Validation of a Smartphone Application for the Assessment of Patients With Mild Cognitive Impairment: MemScreen
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cognitive Impairment
Alzheimer Disease
Lead sponsor: MemScreen
Sponsor class: INDUSTRY
First posted: 2019-01-22
Enrollment: 400
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Population seen on memory clinic for memory complaints.

Brief summary: The clinical evaluation of a patient with a cognitive complaint requires neuropsychological tests, evaluating the integrity of memory and other cognitive functions.

The initial evaluation is made most often by a doctor (general practitioner). In case of need for further examination, a neuropsychological report is made in consultation memory by a neuropsychologist, with further cognitive tests.

The Cognitive Neurology Center at Lariboisière Hospital - Fernand Widal has developed a tool on a digital tablet or smartphone to evaluate cognitive functions: MemScreen.

The purpose of this study is to validate this new neuropsychological test on tablet compared to the neuropsychological reference tests.

Detailed description: Characteristics of MemScreen :

* Smartphone / tablet application developed by the Cognitive Neurology Center at Lariboisière - Fernand Widal Hospital to explore a patient with a cognitive disorder.
* The application is a self-test by the patient under the supervision of a doctor.
* The doctor has an account to be able to pass the test to patients.
* The tablet test is anonymous without the possibility to identify the patient.

Eligibility criteria: Inclusion Criteria:

* Major patients followed in memory clinic.
* Performing a neuropsychological assessment less than 6 months old.
* No visual or motor deficiency impeding the use of a digital tablet.

Exclusion Criteria:

* None.

Primary outcomes:
measure: Ability to detect patients with mild cognitive impairment.
timeFrame: through study completion, an average of 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Centre Neurologie Cognitive Hôpital Fernand Widal
Study officials:
affiliation: Cognitive Neurology Center of Lariboisiere Hospital
name: Julien Dumurgier, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06638684: T Cell Responses to Various Levels of Exercise Stress
Official title: Effects of High- and Moderate-intensity Exercise on T Cell Function in Healthy Young Men
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Immune
Cytokine
Flow Cytometry
Immunoendocrine
Lead sponsor: University of Kansas
Sponsor class: OTHER
First posted: 2024-10-15
Enrollment: 16
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The objective of this project is to quantify the immunoendocrine response to acute stress events combining both physical and psychological challenges. This work will serve as a pilot project examining differential stress induction in response to exercise. Participants will have an instructor with prior military training lead a two-hour training session for 10 recreationally fit male volunteers. You will be randomly assigned to a high-intensity training group to participate in the "military style" training and a low-intensity training group who will participate in a low-intensity cardiovascular training protocol. Blood samples will be collected from you prior to and following the exercise session and these samples will be analyzed for endocrine measures as well as markers of immune function to include chemokines and cytokines.


Eligibility criteria: All subjects will be screened using a health-history questionnaire for contradictions to exercise by American College of Sports Medicine (ACSM) guidelines

Inclusion Criteria:

* Recreationally active
* Between the ages of 18-40,
* Healthy
* Non-obese (BMI \<28 kg/m2)
* Non-smoking
* Free of metabolic or cardiovascular diseases.

Exclusion Criteria:

* Unhealed Fractures
* Thrombophlebitis (blood clots)
* Recent Surgery (within the last three months)
* Recent Uncontrolled Bruising
* Osteomyelitis (acute or chronic bone infection)
* Myositis Ossificans (hardened scarring in muscle tissue of the thigh).

Primary outcomes:
measure: T cell proliferation
timeFrame: 6.5 hours
Secondary outcomes:
measure: Catecholamines (hormones)
timeFrame: 6.5 hours
measure: Complete Blood Count
timeFrame: 6.5 hours
measure: Cortisol
timeFrame: 6.5 hours
Other outcomes:
Locations:
city: Lawrence
country: United States
facility: University of Kansas
state: Kansas
Study officials:
References:
Clinical trial NCT05024084: Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery and Anesthetic Depth
Official title: Comparison of Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery Parameters and Anesthetic Depth: a Randomized Prospective Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Anesthesia
Keywords: general anesthesia
low flow anesthesia
sevoflurane
desflurane
Lead sponsor: Ufuk University
Sponsor class: OTHER
First posted: 2021-08-27
Enrollment: 130
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Minimal flow anesthesia has economic and environmental advantages in addition to providing earlier recovery following general anesthesia. There is a paucity of data concerning the effect of minimal flow anesthesia (fresh gas flow \<0,5 l/min) on recovery parameters. The primary objective of this study is to compare the recovery parameters of desflurane and sevoflurane in minimal flow anesthesia while the secondary objective is to compare the effect of these agents on anesthetic depth using bispectral index.


Eligibility criteria: Inclusion Criteria:

* Ages between 18 and 65
* Patients undergoing elective surgery under general anesthesia
* Patients with an American Society of Anesthesiologists Classification I or II

Exclusion Criteria:

* Patient refusal
* Emergency surgery
* Patients with a contraindication for minimal flow anesthesia
* Uncontrolled diabetes mellitus
* History of serious systemic disease (cardiac, pulmonary, hepatic)
* Utilization of another analgesic technique such as central or peripheral nerve blocks

Primary outcomes:
measure: Time until extubation
timeFrame: Up to 10 minutes after discontinuation of the volatile anesthetic
measure: Time until eye opening
timeFrame: Up to 20 minutes after discontinuation of the volatile anesthetic
measure: Time until transfer readiness
timeFrame: Up to 45 minutes after discontinuation of the volatile anesthetic
Secondary outcomes:
measure: Anesthetic depth provided by the volatile anesthetic
timeFrame: Change in Bispectral Index values at 5, 10, 15, 30, 60 and 120 minutes
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ufuk University Dr. Rıdvan Ege Hospital
Study officials:
affiliation: Ufuk University Faculty of Medicine Department of Anesthesiology and Reanimation
name: Baturay K Kazbek, Ass. Prof.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Taskin D, Gedik E, Kayhan Z. Effects of Minimal Flow Sevoflurane or Desflurane Anaesthesia on Hemodynamic Parameters, Body Temperature and Anaesthetic Consumption. Turk J Anaesthesiol Reanim. 2020 Oct;48(5):356-363. doi: 10.5152/TJAR.2020.39699. Epub 2020 May 5.
citation: Werner JG, Castellon-Larios K, Thongrong C, Knudsen BE, Lowery DS, Antor MA, Bergese SD. Desflurane Allows for a Faster Emergence When Compared to Sevoflurane without Affecting the Baseline Cognitive Recovery Time. Front Med (Lausanne). 2015 Oct 28;2:75. doi: 10.3389/fmed.2015.00075. eCollection 2015.
Clinical trial NCT00684684: Safety and Feasibility Study of the Chartis System
Official title: A Safety and Feasibility Study of the Chartis System During Diagnostic Bronchoscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Bronchoscopy
Keywords: Bronchoscopy
Clinically indicated for routine diagnostic bronchoscopy
Lead sponsor: Pulmonx Corporation
Sponsor class: INDUSTRY
First posted: 2008-05-28
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to evaluate the safety and feasibility of the Chartis System in measuring air flow and pressures in isolated lung compartments during bronchoscopy.


Eligibility criteria: Inclusion Criteria:

* Scheduled to undergo clinically indicated routine diagnostic bronchoscopy

Exclusion Criteria:

* Hyperexcretive chronic bronchitis or excessive sputum secretion
* Active pulmonary infection
* FEV1 \<20% predicted
* FVC \<50% predicted

Primary outcomes:
measure: Adverse events
timeFrame: Until discharge or 24 hours post procedure
Secondary outcomes:
measure: Technical success
timeFrame: During procedure
Other outcomes:
Locations:
city: Heidelberg
country: Germany
facility: Thoraxklinik am Universitatsklinikum Heidelberg
Study officials:
affiliation: Thoraxklinik am Universitatsklinikum Heidelberg
name: Felix Herth, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06403384: Vibration Therapy in Wheelchair Basketball Players
Official title: Effects of Vibration Therapy on Muscle Soreness and Athletic Performance in Wheelchair Basketball Players
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Wheelchair Users
Athletic Performance
Disability
Disabled Persons
Keywords: Athlete
Disabled persons
Exercise
Pain
Proprioception
Upper extremity
Lead sponsor: Karabuk University
Sponsor class: OTHER
First posted: 2024-05-07
Enrollment: 13
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: No study was found that investigated the effect of vibration therapy (VT) on recovery from exercise in WCB players. Therefore, the aim of the study was to investigate the effects of wearable local vibration device on muscle soreness and athletic performance during recovery from exercise in the elbow area in WCB players.

Detailed description: Vibration therapy (VT) has been widely used to increase performance and rehabilitate injuries in athletes. Delayed onset muscle soreness (DOMS), caused by excessive overload after training and competitions, leads to loss of performance. The aim of this study was to investigate the effects of wearable local VT on muscle soreness and athletic performance in wheelchair basketball (WCB) players.

Eligibility criteria: Inclusion Criteria:

* Being a wheelchair basketball players

Exclusion Criteria:

* Having had an upper extremity operation within the last 6 months

Primary outcomes:
measure: Muscle Soreness
timeFrame: pre-exercise (baseline), and 30 minutes and 24 hours post-exercise
measure: Shooting percentage
timeFrame: pre-exercise (baseline), and 30 minutes and 24 hours post-exercise
measure: 20-meter sprint test
timeFrame: pre-exercise (baseline), and 30 minutes and 24 hours post-exercise
measure: Joint position sense
timeFrame: pre-exercise (baseline), and 30 minutes and 24 hours post-exercise
measure: Range of motion
timeFrame: pre-exercise (baseline), and 30 minutes and 24 hours post-exercise
Secondary outcomes:
Other outcomes:
Locations:
city: Karabük
country: Turkey
facility: Karabuk U
Study officials:
affiliation: Karabuk University
name: Mert Uysal
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04621084: Influence of the COVId-19 Pandemic on STRESS and Eating Habits
Official title: Influence of the COVId-19 Pandemic on STRESS and Eating Habits
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Nutrition
Keywords: nutrition
Covid-19
Eating habits
Stress
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2020-11-09
Enrollment: 1000
Sex: ALL
Minimum age (years): 10
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All volunteers

Brief summary: The Coronavirus has caused containment of more than a third of the world's population. Containment can drastically change lifestyle habits, including eating habits such as the number of meals, meal times or their composition. However, there is currently no data on the influence of confinement on eating habits.

Detailed description: This is an observational study by REDCap questionnaire® via a flyer deposited in the waiting room of the COVID screening centres. No incentive to complete the questionnaire will be made.

The self-administered questionnaire will assess stress, changes in eating habits, and relationships with socio-demographic or lifestyle factors.

This questionnaire includes 9 specific questions on nutrition and 40 general questions.

Eligibility criteria: Inclusion Criteria:

* All volunteers who are screened

Exclusion Criteria:

* none

Primary outcomes:
measure: Stress measures
timeFrame: Day 1
Secondary outcomes:
measure: Nutrition
timeFrame: Day 1
Other outcomes:
measure: Sociodemographic characteristics
timeFrame: Day 1
Locations:
city: clermont-Ferrand
country: France
facility: Clermont-Ferrand University Hospital
state: Aura
Study officials:
References:
Clinical trial NCT05915884: The Triglyceride/Glucose Index and SGLT-2 Inhibitors
Official title: Investigation of the Triglyceride/Glucose Index in Diabetic Patients Using SGLT-2 Inhibitor
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Metabolic Disease
Diabetes
Keywords: SGLT-2 inhibitor
triglyceride index
Lead sponsor: Samsun Education and Research Hospital
Sponsor class: OTHER
First posted: 2023-06-23
Enrollment: 55
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients with a diagnosis of type 2 Diabetes Mellitus who applied to Samsun Training and Research Hospital Internal Medicine outpatient clinic for 12 months in 2022 and were started on SGLT-2 inhibitor will be examined. According to the inclusion and exclusion criteria stated above, the patients will be evaluated and the data of the patients admitted to the study will be analyzed.

Brief summary: This study was designed to evaluate the change in triglyceride glucose index, one of the atherosclerotic markers, in patients with type 2 DM followed in the Internal Medicine Clinic of Samsun University, Samsun Training, and Research Hospital.

Methods: The data of the patients who were followed up for at least 3 months by making a retrospective file review will be recorded and analyzed. It is planned to start the study following the ethics committee's approval.

Detailed description: The data of all patients who applied to Samsun Training and Research Hospital Internal Medicine outpatient clinic for 12 months in 2022 and were started on SGLT-2 inhibitor will be examined. According to the inclusion and exclusion criteria stated below, the patients will be evaluated and the data of the patients admitted to the study will be analyzed. The triglyceride glucose index of the patients before starting the SGLT-2 injection and the trig/glucose index at the end of 3 months of treatment will be calculated by the researchers using the data in the system. No additional blood tests or laboratory analyses will be performed on the patients. Triglyceride, glucose, and glycosylated hemoglobin values were checked at the beginning of the treatment and at the 3rd-month follow-up.

Eligibility criteria: Inclusion Criteria:

* Type 2 DM
* Age \>18 years old
* Dapagliflozin 10 mg or empagliflozin 10 mg or 25 mg
* 3 months follow-up period

Exclusion Criteria:

* Type 1 diabetes
* Gestational diabetes
* Age \< 18 years old
* Insufficient or missed laboratory test results
* Medical treatment for dyslipidemia
* Hypothyroidism

Primary outcomes:
measure: Change in triglyceride index
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Samsun
country: Turkey
facility: Samsun Education and Research Hospital
state: İlkadım
Study officials:
affiliation: Samsun Education and Research Hospital
name: DÜRİYE SILA KARAGÖZ ÖZEN
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04172584: Awareness & Use of Emergency Contraception
Official title: Awareness & Use of Emergency Contraception Among Women Attending Kidwany MCH Center , Assiut City
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Emergency Contraception
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2019-11-21
Enrollment: 400
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 45
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Married women in reproductive age (15 - 49 years) clients who are attending Kidwany MCH centre, Assiut city.

Brief summary: General objective:

To decrease the percentage of unwanted and/or unplanned pregnancies and their consequences on women's reproductive health.

Specific objectives:

1. To assess awareness of the study participants about emergency contraception.
2. Determine the percentage of ever use among the participants.
3. To identify factors that affect the awareness and use of emergency contraception among the study participants


Eligibility criteria: Inclusion Criteria:

* Married women in reproductive age (15 - 49 years)

Exclusion Criteria:

* Infertile and postmenopausal women.

Primary outcomes:
measure: Percent of awareness and use of emergency contraception
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Mohammed S, Abdulai AM, Iddrisu OA. Pre-service knowledge, perception, and use of emergency contraception among future healthcare providers in northern Ghana. Contracept Reprod Med. 2019 Jan 24;4:1. doi: 10.1186/s40834-018-0082-9. eCollection 2019.
citation: Mittal S. Emergency contraception: which is the best? Minerva Ginecol. 2016 Dec;68(6):687-99. Epub 2016 Apr 15.
citation: Association of Women's Health, Obstetric and Neonatal Nurses. Emergency Contraception. J Obstet Gynecol Neonatal Nurs. 2017 Nov-Dec;46(6):886-888. doi: 10.1016/j.jogn.2017.09.004. No abstract available.