Clinical trial NCT06704464: Investigation of Validity and Reliability of the Minnesota Manual Dexterity Test in Patients With Multiple Sclerosis
Official title: Investigation of Validity and Reliability of the Minnesota Manual Dexterity Test in Patients With Multiple Sclerosis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Multiple Sclerosis
Keywords: Minnesota manual dexterity
reliability
validity
multiple sclerosis
hand function
Lead sponsor: Gazi University
Sponsor class: OTHER
Collaborators: name: Cumhuriyet University
First posted: 2024-11-26
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with Multiple Sclerosis who apply to Sivas Cumhuriyet University, Department of Physiotherapy and Rehabilitation will be invited to this study.

Brief summary: Many assessment tools have been developed and used to evaluate upper extremity functions in multiple sclerosis (MS) patients. While each test has its strengths and weaknesses, the most significant limitation of these tests is that only a limited number assess both hands simultaneously. On the other hand, most daily life activities require the coordinated use of both hands. In MS patients, bilateral impairments in hand functions can also be observed. Therefore, there is a need for bilateral assessment tools.

Unlike many other assessment tools, the Minnesota Manual Dexterity Test (MMDT) allows for simultaneous evaluation of both hands. In addition to manual dexterity, it also assesses hand-eye coordination and gross motor skills. The MMDT consists of five subtests: placing, turning, displacing, single-hand turning and placing, and two-hand turning and placing. The validity of the MMDT has also been examined in MS patients.

Our study aims to evaluate the reliability and validity of the MMDT in MS patients. The cutoff times that best distinguish individuals with MS from healthy individuals will also be examined. The study aims to systematically and thoroughly evaluate the MMDT, establish it as a valid and reliable method for MS patients, and provide a new perspective on assessing hand functions.

Detailed description: At baseline, the MMDT, EDSS, 9-hole peg test (9-HPT), ABILHAND survey, and Jebsen-Taylor Hand Function Test (JTHFT) will be applied to the MS group. The MMDT will be repeated seven days after the first application in MS. Healthy controls are going to perform only the MMDT.

Eligibility criteria: Inclusion Criteria:

* Age at least 18 years,
* Neurologist-diagnosed Multiple Sclerosis,
* Expanded Disability Status Scale (EDSS) score between 0-6.5
* No MS exacerbation within the last 3 months,
* Use of stable medication in the last 3 months.

Exclusion Criteria:

* Having any vision, hearing or perception problems that may affect the research results,
* Having an orthopedic problem that may affect manual skills in the upper extremity,
* Having a cardiovascular, pulmonary disorder

Primary outcomes:
measure: Minnesota Manual Dexterity Test
timeFrame: baseline (on the predetermined assessment day)
measure: Minnesota Manual Dexterity Test-second
timeFrame: the second assessment will be conducted after the seven days
Secondary outcomes:
measure: 9-Hole Peg Test
timeFrame: baseline (on the predetermined assessment day)
measure: ABILHAND
timeFrame: baseline (on the predetermined assessment day)
measure: The Jebsen Hand Function Test
timeFrame: baseline (on the predetermined assessment day)
measure: The Expanded Disability Status Scale
timeFrame: baseline (on the predetermined assessment day)
Other outcomes:
Locations:
city: Sivas
country: Turkey
facility: Sivas Cumhuriyet Üniversity
Study officials:
References:
citation: Celik RGG. Upper Extremity Capability Tests in Multiple Sclerosis. Noro Psikiyatr Ars. 2018;55(Suppl 1):S54-S57. doi: 10.29399/npa.23338.
citation: Hervault M, Balto JM, Hubbard EA, Motl RW. Reliability, precision, and clinically important change of the Nine-Hole Peg Test in individuals with multiple sclerosis. Int J Rehabil Res. 2017 Mar;40(1):91-93. doi: 10.1097/MRR.0000000000000209.