louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06964321: Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion
Official title: Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Malignant Pleural Effusion
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-05-09
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Pleural effusion is common in different diseases and especially malignant effusions can have fast onset symptoms such as chest pain, dyspnoea, and coughing. Malignant pleural effusion (MPE) is an exudative effusion with malignant cells.

It is a common symptom and accompanying presentation of metastatic disease. It Impacts up to 15% of all patients with cancer and is the most common in breast, lung, cancer, lymphoma, and gynaecological malignancies . There are 150,000 new cases of MPE in the United States yearly and 100,000 in Europe . Patients have an overall survival (OS) rate of 3-12 months after the initial diagnosis . Malignant pleural effusion (MPE) poses significant challenges in management, impacting patient quality of life and overall prognosis. Almost all radiological procedures can help diagnose pleural effusions . Thoracentesis is used as a diagnostic and therapeutic tool. The procedure has been modified with the addition of ultrasound, that is very functional for targeting certain anatomical areas of the pleura and finding an appropriate entry point . Three primary strategies are commonly employed: intercostal tube drainage, big tail catheter drainage, and ultrasound-guided aspiration. This study aims to evaluate these methods' efficacy, safety, and outcomes. To compare intercostal tube drainage, big tail catheter drainage, and ultrasound-guided aspiration in managing massive malignant pleural effusion (MPE).


Eligibility criteria: Inclusion Criteria:

* Adult patient aged 18 years old and above.
* Patients diagnosed with massive malignant pleural effusion (MPE) requiring intervention.

Exclusion Criteria:

* Pediatric patients aged below 18 years
* Patients with non-malignant causes of pleural effusion.

Primary outcomes:
measure: Resolution of Pleural Effusion
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02835521: Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection
Official title: Influence of Perception of Patients Suffering of Osteoarthritis of Knee Over the Effectiveness and Tolerance in Intra-articular Injection of Corticoids: a Prospective, Controlled and Randomized Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Knee Osteoarthritis
Lead sponsor: Federal University of São Paulo
Sponsor class: OTHER
First posted: 2016-07-18
Enrollment: 100
Sex: ALL
Minimum age (years): 50
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Introduction; reception must be understood as the offered attention within the relationship between a healthcare worker and the patient, including attitudes of inclusion, hearing, valorization of complains and identification of needs, being these individual collective. As a part of this process, communication is a primary and indispensable toll through which the healthcare team and the patient interchange information.

Objective: to evaluate the influence of perception of patients suffering of knee osteoarthritis over fear, catastrophizing of pain and effectiveness, related to intra-articular injection od corticosteroids.

Material and method: it will be performed a prospective, controlled and randomized study eith a blind evaluator on patients with symptomatic knee osteoarthritis submitted to joint injection. A hundred patients suffering of symptomatic knee osteoarthritis coming from the outpatient area of Rheumatology Division of Federal University of Sao Paulo (UNIFESP) will be evaluated, 50 belonging to the intervention group (reception) and 50 to a control group.


Eligibility criteria: Inclusion Criteria:

* knee osteoarthritis according to american college of rheumatology criteria
* no previous experience of joint injection
* stable use of drugs for osteoarthritis treatment for at least 3 months
* stable dose of corticosteroids, non hormonal anti-inflammatory and analgesics in the previous month
* pain on knee between 3 and 7 in the visual analogue scale
* signe the informed consent term
* radiologic classification between 1-3 (kellgren and Lawrence classification)

Exclusion Criteria:

* joint disease of different etiology
* coagulation alteration
* non treated fibromyalgia
* litigation
* diabetes mellitus and systemic arterial hypertension out of control
* allergy of lidocaine or triamcinolone hexacetonide

Primary outcomes:
measure: Change on pain
timeFrame: baseline, after 1, 4 and 12 weeks
Secondary outcomes:
measure: Change on functional capacity
timeFrame: baseline, after 1, 4 and 12 weeks
measure: Change on Catastrophizing
timeFrame: baseline, after 1, 4 and 12 weeks
measure: Change on functional capacity
timeFrame: baseline, after 1, 4 and 12 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01261221: Pilot Study of Metabolic Syndromes and HIV Infections in Indian Tibetans
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Metabolic Syndromes
HIV Infection
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
First posted: 2010-12-16
Enrollment: 137
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Tibetan colony of India

Brief summary: Kaohsiung Medical University Chung-Ho Memorial Hospital will provide a long-term free medical service in Indian Tibetans since July 2010. The investigators plan to investigate metabolic syndromes and HIV infection in Indian Tibetan community. The investigators will survey the prevalence and risk factors by means of HIV quick test and questionnaires. Since there is lacking of prevalence survey for metabolic syndrome and HIV infection in Tibetan colony of India, the investigiators will carry out this survey under the support and assistance of Department of Health of Central Tibetan Government.


Eligibility criteria: Inclusion Criteria:

Tibetan colony of India

Exclusion Criteria:

non-Tibetan colony of India

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
Study officials:
References:
Clinical trial NCT02706821: Anti-diabetic Effects of Persimmon Leaf Extract
Official title: An Eight-week, Randomized, Double-blind, Placebo-controlled Crossover Clinical Trial of Persimmon Leaf Extract on Anti-diabetes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prediabetes
Keywords: prediabetes
blood glucose
clinical trial
Lead sponsor: Chonbuk National University Hospital
Sponsor class: OTHER
First posted: 2016-03-11
Enrollment: 34
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The investigators performed a 8-week, randomized, double-blind, placebo-controlled crossover human trial to evaluate the efficacy and safety of persimmon leaf extract on blood glucose. The investigators measures changes in diabetes associated parameters, including fasting blood glucose, postprandial blood glucose, insulin, C-peptide and HbA1c.


Eligibility criteria: Inclusion Criteria:

* Age 20-75 years
* Fasting blood glucose (FPG) 100\~140 mg/dL or postprandial blood glucose (PPG) 140\~250 mg/dL

Exclusion Criteria:

* FPG more than 140 mg/dL
* 2h PPG more than 200 mg/dL
* Type 1 diabetes or HbA1c more than 9.0%
* treatment with corticosteroids within the past 4 weeks
* cardiovascular disease

Primary outcomes:
measure: Fasting and postprandial plasma glucose
timeFrame: baseline day 57, 85 and 141
Secondary outcomes:
measure: Fasting plasma insulin
timeFrame: baseline and day 57, 85 and 141
measure: C-peptide
timeFrame: baseline and day 57, 85 and 141
measure: Glycated hemoglobin (HbA1c)
timeFrame: baseline and day 57, 85 and 141
measure: adiponectin
timeFrame: baseline and day 57, 85 and 141
measure: leptin
timeFrame: baseline and day 57, 85 and 141
measure: resistin
timeFrame: baseline and day 57, 85 and 141
measure: Markers of Inflammation
timeFrame: baseline and day 57, 85 and 141
measure: Tumor necrosis factor alpha (TNF-α)
timeFrame: baseline and day 57, 85 and 141
measure: Interleukin-6 (IL-6)
timeFrame: baseline and day 57, 85 and 141
measure: Monocyte chemoattractant protein-1 (MCP-1)
timeFrame: baseline and day 57, 85 and 141
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03183921: Study on ICU Patients With Nosocomial Lower Respiratory Tract Infections
Official title: Epidemiological, Microbiological and Clinical Profile of Ice Patients With Nosocomial Lower Respiratory Tract Infections
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pneumonia
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2017-06-12
Enrollment: 600
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All ICU patients with a documented Nosocomial Lower Respiratory Tract Infection will be eligible for this epidemiological, clinical and microbiological investigation

Brief summary: This is a multicentre, multinational, prospective observational investigation on ICU critically ill patients affected by nosocomial pneumonia, defined as: Out of ICU Hospital-acquired Pneumonia (HAP), Non-ventilator ICU-acquired Pneumonia (NV ICUAP), Ventilator associated pneumonia (VAP) Ventilator associated tracheobronchitis (VAT).


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years
* Diagnosis of nosocomial pneumonia
* ICU and HDU admission (patient may be admitted to the ICU with NP or may develop pneumonia during ICU stay)
* Informed consent (if required)

Exclusion Criteria:

* Community Acquired Infection
* Absence of Microbiological Findings

Primary outcomes:
measure: Number of patients dying among the different pneumonia categories
timeFrame: 28 days
Secondary outcomes:
measure: Number of patients with different epidemiological patterns
timeFrame: 28 days
measure: Number of patients with specific microbiological profiles
timeFrame: 28 days
measure: Number of patients with specific clinical characteristics
timeFrame: 28 days
measure: Number of patients with different therapeutically interventions
timeFrame: 28 days
Other outcomes:
Locations:
city: Dublin
country: Ireland
facility: St James's University Hospital
Study officials:
References:
Clinical trial NCT05109221: Ultrasonography in Predicting Difficult Intubation in Obese Emergency Surgical Patients
Official title: Validity of Ultrasonography in Predicting Difficult Laryngoscopy and Confirming Endotracheal Intubation in Obese Emergency Surgical Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Preoperative Ultrasound Assessment of the Upper Airway Can Predict Difficult Laryngscopy in Obese at Emergency Operations
Keywords: ultrasound _difficult intubation _obese _emergency operations
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2021-11-05
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: obese emergency surgical patients

Brief summary: Validity of ultrasonography in predicting difficult laryngoscopy and confirming endotracheal intubation in obese emergency surgical patients

Detailed description: The aim of the study is to determine whether preoperative ultrasound assessment of of the upper airway can predict difficult laryngscopy in emergency surgical obese patients , by analysis correlations between ultrasound measurements of anterior cervical soft in the upper airway, and the Cormack-Lehane grade. And evaluate its role in confirming the endotracheal placement The secondary objective was to determine whether clinical screening tests are independent predictors of difficult airway.

Eligibility criteria: Inclusion Criteria:

* Adult obese patients (BMI\>35) of both sex aged from 18 to 60 years undergoing urgent surgeries under general anasthesia with tracheal intubation.

Exclusion Criteria:

* . Patients with removable upper dentures, upper airway pathology, cervical spine fractures, full stomach, maxillofacial trauma or unstable patients and pregnant women will be excluded from the study

Primary outcomes:
measure: prediction of difficult intubation in obese emergency surgical patients by ultrasound
timeFrame: 30minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Minya
country: Egypt
facility: Hemmat amer mohamed
Study officials:
References:
Clinical trial NCT00431821: Reshaping Exercise Habits and Beliefs (REHAB)
Official title: Reshaping Exercise Habits and Beliefs (REHAB): Pilot Testing of a Behavioral Intervention to Improve Mobility After Stroke
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebrovascular Accident
Stroke
Keywords: Exercise
Rehabilitation
Stroke
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2007-02-06
Enrollment: 90
Sex: ALL
Minimum age (years): 40
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Regular exercise has been demonstrated to improve muscle strength, balance, coordination as well as improve cardiovascular fitness levels and overall quality of life in stroke survivors. This study is designed to test the feasibility and effectiveness of a 12-week intervention to education and encourage stroke survivors to exercise following discharge from rehabilitation settings using a walking program and targeted functional activity homework.


Eligibility criteria: Inclusion Criteria:

1. 40-85 years old ischemic Stroke patients,
2. Stroke onset \<90 days at enrollment,
3. Hemiparetic gait disorder,
4. Patients able to walk 30ft with or w/out assistive device,
5. Sufficient English comprehension to understand instructions, provide consent, and answer questions,
6. Lives within 30 miles of the Greater Baltimore area.

Exclusion Criteria:

1. Dementia (extended MMSE \<85 or \<80 if education level below 9th grade),
2. Untreated major clinical depression (CES-D\>16) and confirmed with clinical interview,
3. Heavy alcohol use (\<3 oz liquor, 3, 4-oz glasses of wine, or 3, 12- oz beers daily),
4. Active cancer, or any illness with a life expectancy of less than 6 months,
5. Any condition in which exercise activity would be contraindicated including, but not limited to: unstable angina, cardiac ischemic event within the past 6 months, congestive heart failure (Stage III or IV), major orthopedic chronic pain or non-stroke neuromuscular disorders restricting exercise, oxygen-dependent COPD or peripheral neuropathy.

Primary outcomes:
measure: Ambulatory Activity Profile
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
state: Maryland
Study officials:
affiliation: Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
name: Marianne Shaughnessy, RN PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Crocker TF, Brown L, Lam N, Wray F, Knapp P, Forster A. Information provision for stroke survivors and their carers. Cochrane Database Syst Rev. 2021 Nov 23;11(11):CD001919. doi: 10.1002/14651858.CD001919.pub4.
citation: Saunders DH, Mead GE, Fitzsimons C, Kelly P, van Wijck F, Verschuren O, Backx K, English C. Interventions for reducing sedentary behaviour in people with stroke. Cochrane Database Syst Rev. 2021 Jun 29;6(6):CD012996. doi: 10.1002/14651858.CD012996.pub2.
Clinical trial NCT03410121: Comparison of Humeral or Thoracic Implantation of an Central Veinous Access by an Implantable Venous Access Device in Patients With Solid Tumors Requiring Chemotherapy
Official title: Phase IV Study Comparing Humeral or Thoracic Implantation of an Central Veinous Access by an Implantable Venous Access Device in Patients With Solid Tumors Requiring Intravenous Chemotherapy
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Solid Tumor, Adult
Chemotherapy Treatment
Advanced or Metastasis Stage
Lead sponsor: Center Eugene Marquis
Sponsor class: OTHER
First posted: 2018-01-25
Enrollment: 361
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The aim of this study is to compare the humeral and thoracic implantation of a central venous access by an implantable device in patients with solids tumors who require intravenous chemotherapy. This is a monocentric randomized study. 572 patients will be recruited for 2 years. They will be randomized either in the thoracic implantation, either in the humeral implantation Due to the 1:3 randomization, 143 patients will be randomized in the humeral arm and 429 into the thoracic one. Number of complications related to the implantable device, medico-economic analysis as well as patient satisfaction will be assessed.

Every patients with solid tumor requiring medical device implantation for intravenous chemotherapy treatment will be eligible.

Both humeral and thoracic implantation of medical device are standard procedures. The randomization in a specific arm is the study procedure and is considered as an interventional study in France.


Eligibility criteria: Inclusion Criteria:

* Patients with solid tumors at an Advanced or metastasis stage requiring placement of implantable catheter for intravenous chemotherapy treatment
* Older than 18 years
* Express signed consent

Exclusion Criteria:

* Life expectancy less than 12 months assessed by investigator
* Infection or uncontrolled suspected infection
* Medical contraindication to port implantation by catheter in thoracic or humeral location
* Pregnant or lactating women
* Abnormal coagulation
* Immunosuppressed patients (for example known hepatitis B or C, or known positive Human Immunodeficiency Virus due to the spreading risk)
* Patient not affiliated to the French social security
* Access time to the humeral or thoracic port placement higher than 15 days (from the randomization theoretical date)
* Protected Adult or adult deprived of liberty

Primary outcomes:
measure: Number of complications related to Implantable Venous Access Device
timeFrame: 3 months after medical device placement
Secondary outcomes:
Other outcomes:
Locations:
city: Rennes
country: France
facility: Center Eugene Marquis
state: Brittany
Study officials:
affiliation: Centre Eugène Marquis, Rennes, France
name: Laurence CROUZET, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05811221: Application of Different Modes of Esketamine Administration in Pediatric Day Circumcision
Official title: Application of Different Modes of Esketamine Administration in Pediatric Day Circumcision
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pain
Keywords: Pediatric circumcision
Mode of administration
Day surgery
Esketamine
Lead sponsor: Yangzhou University
Sponsor class: OTHER
First posted: 2023-04-13
Enrollment: 70
Sex: MALE
Minimum age (years): 6
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: To explore the application of different administration modes of esketamine in pediatric day circumcision, in order to find an anesthesia scheme more suitable for day pediatric circumcision.

Detailed description: The current clinical study believes that esketamine is suitable for pediatric anesthesia because of its advantages of light respiratory depression, low secretions, low incidence of psychomotor reactions and fast recovery of anesthesia, but there are few related studies on its administration mode and timing in clinical application, this study aims to explore the application of different administration methods of esketamine in pediatric day circumcision, and find an anesthesia scheme more suitable for day circumcision, in order to provide new ideas for anesthesia for pediatric day circumcision.

Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists (ASA) class I and II children
* Age 5-12 years
* Foreskin cerclage is proposed
* No history of upper respiratory tract infection in the past two weeks
* Obtain the consent of the child's family

Exclusion Criteria:

* Hepatic and renal insufficiency, coagulation dysfunction
* Those who are allergic to esketamine
* History of cognitive impairment
* epilepsy
* other psychiatric and neurological disorders

Primary outcomes:
measure: One-time success rate of anesthesia
timeFrame: During surgery
Secondary outcomes:
measure: Systolic blood pressure
timeFrame: During surgery
measure: Diastolic blood pressure
timeFrame: During surgery
measure: Heart rate
timeFrame: During surgery
measure: intraoperative propofol dosage, esketamine dosage
timeFrame: During surgery
measure: Duration of surgery
timeFrame: During surgery
measure: Time to open eyes
timeFrame: During surgery
measure: Time to talk
timeFrame: During surgery
measure: VAS(visual analogue scale) score
timeFrame: 12 hours after the end of surgery
measure: Incidence of adverse effects (hypotension, hypertension, respiratory depression, postoperative pain, diplopia, mania)
timeFrame: 12 hours after the end of surgery
Other outcomes:
Locations:
Study officials:
References: