louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06163664: Role of ChatGPT in Vestibular Schwannoma Management
Official title: Role of ChatGPT in Vestibular Schwannoma Management
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Vestibular Schwannoma
Lead sponsor: University of Southern California
Sponsor class: OTHER
First posted: 2023-12-11
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Previous studies have demonstrated that patients frequently undergo significant decision conflict regarding major medical decisions in otolaryngology. There lack validated tools available for decision support for patients. While limited evidence has demonstrated that clinical decision support tools can alleviate decision conflict for patients with diagnosis in otolaryngology, conversational language models were not employed in these studies and may provide additional benefit in this context. This study seeks to evaluate the efficacy of using ChatGPT, a conversational language model with basic clinical knowledge, in alleviating decision conflict for patients with new diagnosis in otolaryngology. For this pilot study, vestibular schwannoma, a benign tumor that develops on the vestibular nerve with known clinical equipoise, has been chosen for the initial study diagnosis. Efficacy will be evaluated by comparison of responses to the Decisional Conflict Scale (DCS) and Satisfaction with Decision (SWD) scores between a group given training in ChatGPT and a control group (no ChatGPT training).


Eligibility criteria: Inclusion Criteria:

* 18 years or older
* Diagnosed with vestibular schwannoma
* Have access to internet-enabled device that is compatible with ChatGPT

Exclusion Criteria:

* \< 18 years old
* patient without diagnosis of vestibular schwannoma
* patient does not have access to internet-enabled device
* patient who declines study participation

Primary outcomes:
measure: Changes in scores of Decisional Conflict Scale after ChatGPT use
timeFrame: baseline, 1 week follow up, 2 week follow up
measure: Changes in scores of Satisfaction with Decision after ChatGPT use
timeFrame: baseline, 1 week follow up, 2 week follow up
measure: Changes in scores for Knowledge on vestibular schwannoma management after ChatGPT use
timeFrame: baseline, 1 week follow up, 2 week follow up
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06096064: Medication Use Evaluation (MUE) for Continuous Heparin Infusions in Hospitalized Patients
Official title: Medication Use Evaluation (MUE) for Continuous Heparin Infusions in Hospitalized Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Unfractionated Heparin
Lead sponsor: Methodist Health System
Sponsor class: OTHER
First posted: 2023-10-23
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: • Patient's aged 18 years or older with a confirmed diagnosis of DVT/PE based on imaging or a confirmed diagnosis of ACS requiring heparin therapy

Brief summary: Unfractionated heparin (UFH) is an anticoagulant to prevent thrombus formation or worsening of an existing thrombus. It is indicated for patients with deep vein thrombosis/pulmonary embolism (DVT/PE) or acute coronary syndrome (ACS). Unfractionated heparin treatment consists of an initial bolus followed by a continuous infusion that is adjusted based on the patient's subsequent partial thromboplastin time (PTT) levels

Detailed description: Unfractionated heparin is classified as a high-alert medication in the acute care setting.3 Therapeutic anticoagulation is a high priority for healthcare teams because the impacts of inadequate anticoagulation can lead to life threatening events such as a major bleed or thrombus formation and/or death.

Eligibility criteria: Inclusion Criteria:

* Patient's aged 18 years or older with a confirmed diagnosis of DVT/PE based on imaging or a confirmed diagnosis of ACS requiring heparin therapy

Exclusion Criteria:

* History of bleeding in the last 30 days
* History of HIT
* Use of systemic anticoagulants for another indication
* Presence of coagulation disorder prior to admission (i.e. hemophilia, sickle cell anemia, etc.)

Primary outcomes:
measure: Incidents of deviations from protocol
timeFrame: 30 Days
Secondary outcomes:
Other outcomes:
Locations:
city: Dallas
country: United States
facility: Methodist Richardson Medical Center
state: Texas
Study officials:
References:
Clinical trial NCT02290964: Effect of Acute Normovolemic Haemodilution on Allogenic Transfusion Needs In Laparotomy
Official title: Effect of Acute Normovolemic Haemodilution on Allogenic Transfusion Needs in Patients Undergoing Laparotomy Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Surgery
Keywords: Acute normovolemic hemodilution
allogeneic transfusion
Lead sponsor: Universitas Padjadjaran
Sponsor class: OTHER
First posted: 2014-11-14
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is aimed to determine if acute normovolemic hemodilution (ANH), an established blood conservation technique, reduces the requirement for allogeneic blood transfusion in operations with prediction of surgical bleeding over 20% of estimated blood volume (EBV)

Detailed description: Allogeneic blood transfusion is often done during surgery to save life- threatening conditions. Blood conservation is a method that can reduce peri-operative allogeneic blood transfusion. This study has been conducted on 34 patients underwent laparotomy surgery with bleeding more than 20% of EBV. After being informed concent, research subjects were randomized into two groups: ANH (conducted ANH) and control group (without ANH). After starting general anesthesia, the ANH group was withdrawing blood based on Gross formula. Restoration of circulated volume was instituted by infusion of colloids. In control group, the operation was started right after the induction of anesthesia. The monitoring of blood pressure, heart rate, the amount of bleeding, total fluid, urine production, hemoglobin concentration and number of allogenic transfusion were recorded.

Eligibility criteria: Inclusion Criteria:

* Adult patients scheduled for laparotomy under general anesthesia with potentially surgical bleeding \> 20% of EBV
* ASA physical status I - II
* hemoglobin level before surgery \> 11 g / dl for men and \> 10 g / dl for women

Exclusion Criteria:

* impaired coagulation (INR\> 1.5 and / or platelet count \<100,000)
* active infection
* disruption of metabolic liver
* received anti fibrinolytic drugs

Primary outcomes:
measure: Reduction of allogenic transfusion requirements
timeFrame: During surgery and 24 hours post surgery with target Hb > 8gr/dl
Secondary outcomes:
Other outcomes:
Locations:
city: Bandung
country: Indonesia
facility: Department of Anesthesiology and Therapy Intensive Faculty of Medicine/Dr. Hasan Sadikin General Hospital
state: West Java
Study officials:
affiliation: Department of Anesthesiology and Therapy Intensive Faculty of Medicine Universitas Padjadjaran Dr. Hasan Sadikin General Hospital Bandung
name: Heni H Listianto, MD
role: STUDY_CHAIR
References:
Clinical trial NCT04476264: Novel Use of an Adjustable Single 8-0 Polypropylene Suture of Scleral Fixation Without Conjunctival Dissection
Official title: Novel Use of an Adjustable Single 8-0 Polypropylene Suture of Scleral Fixation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Suture, Complication
Lead sponsor: Beijing Tongren Hospital
Sponsor class: OTHER
First posted: 2020-07-20
Enrollment: 27
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Any participants who used an adjustable single 8-0 polypropylene suture of scleral fixation without conjunctival dissection could be included.

Brief summary: 1. observe the effectivity of an adjustable single 8-0 polypropylene suture to scleral fix without conjunctival dissection for the treatment with aphakia or inadequate posterior capsule support.
2. observe the complication of this surgery method.


Eligibility criteria: Inclusion Criteria:

* Any patients who used an adjustable single 8-0 polypropylene suture of scleral fixation without conjunctival dissection could be included.

Exclusion Criteria:

* Data from patients with a \< 6-month postoperative follow-up or with incomplete operative or postoperative medical records were excluded from this study. Enrolled patients had complete records pertaining to their visual acuity (VA), slit-lamp photographs, and ultrasound biomicroscope (UBM) findings.

Primary outcomes:
measure: uncorrected VA
timeFrame: at 3 months postoperatively
Secondary outcomes:
measure: Postoperative complications
timeFrame: follow up time is larger 6 month
Other outcomes:
measure: IOL and tunnel location
timeFrame: at 2 months postoperatively
Locations:
city: Beijing
country: China
facility: Beijing Tongren Hospital
state: Beijing
Study officials:
References:
citation: Mo B, Li SF. Novel use of an adjustable single 8-0 polypropylene suture of scleral fixation without conjunctival dissection. BMC Ophthalmol. 2020 Jul 25;20(1):304. doi: 10.1186/s12886-020-01558-y.
Clinical trial NCT03640364: Bilateral Sacrospinous Colposuspension (BSC) in the Female Genital Prolapse With Urinary Urge Symptomatology
Official title: Multicenter Prospective Non-randomised Trial of Bilateral Sacrospinous Colposuspension (BSC) in the Treatment of Female Genital Prolapse Accompanied by Urinary Urge Symptomatology
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Urinary Urge Incontinence
Keywords: pelvic organ prolapse
incontinence
minimally invasive
vaginal surgery
macroporous
lightweight
mesh
polypropylene
POP
urge
Lead sponsor: Helios Medical Center Schleswig
Sponsor class: OTHER
First posted: 2018-08-21
Enrollment: 250
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: female patients with pelvic organ prolapse suffering from symptoms of urinary urge incontinence

Brief summary: Prospective non-randomised trial investigating the effect of vaginal vault Suspension on urge symptomatology in female patients with pelvic organ prolapse

Detailed description: A multicenter multinational Trial is performed in 250 female patients with pelvic organ prolapse (POP) and symptoms of urinary urge incontinence.

Dependent on the presence or abscence of the uterus patients are treated with bilateral sacrospinous uterine or vaginal vault suspension (BSC) by means of a tape specifically designed for this purpose.

Eligibility criteria: Inclusion Criteria:

* urge urinary incontinence or symptoms thereof
* 18 years old or older
* Compliance regarding data collection, therapy and follow-up
* written informed consent
* simultaneous performance of surgical colporrhaphy permitted

Exclusion Criteria:

* pelvic organ prolapse without symptoms of urinary urge
* age less than 18 years
* no informed consent
* lack of compliance
* adverse reaction to polypropylene
* life expectancy less than anticipated duration of protocol
* ASA 4

Primary outcomes:
measure: Influence of BSC placement on symptoms of urinary urge expressed by change in clinical examination
timeFrame: Checked after 6 weeks, six months and twelve months
measure: Change in score of standardized ICIQ documentation
timeFrame: Checked after 6 weeks, six months and twelve months
Secondary outcomes:
measure: Anatomical correction of female pelvic organ prolapse
timeFrame: Checked after 6 weeks, six months and twelve months
Other outcomes:
Locations:
city: Schleswig
country: Germany
facility: Helios Medical Center
Study officials:
affiliation: Helios Medical Center Schleswig
name: Dirk G Kieback, MD,Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01886664: Comparison of PRS According to Inhalation Agent During LDLT
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Liver Transplantation
Postreperfusion Syndrome
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2013-06-26
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The investigators tried to evaluate the effect of desflurane on the incidence of postreperfusion syndrome during living donor liver transplantation surgery. The investigators used sevoflurane as a comparison.


Eligibility criteria: Inclusion Criteria:

* elective LDLT

Exclusion Criteria:

* age \< 18, age \> 65
* patient refusal
* re-transplantation

Primary outcomes:
measure: frequency of PRS
timeFrame: immediately after reperfusion
Secondary outcomes:
measure: ICU length of stay
timeFrame: after LT until the patient is transferred to the ward
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References:
citation: Lee J, Yoo YJ, Lee JM, Park YJ, Ryu HG. Sevoflurane Versus Desflurane on the Incidence of Postreperfusion Syndrome During Living Donor Liver Transplantation: A Randomized Controlled Trial. Transplantation. 2016 Mar;100(3):600-6. doi: 10.1097/TP.0000000000000874.
Clinical trial NCT02656264: The Chronic Pain Incidence After Elective and Urgent Cesarean Sections
Official title: The Chronic Pain Incidence After Elective and Urgent Cesarean Sections
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Pain
Lead sponsor: Tokat Gaziosmanpasa University
Sponsor class: OTHER
First posted: 2016-01-14
Enrollment: 200
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: * Female
* 18 - 45 years of age
* underwent elective or urgent cesarean section

Brief summary: The purpose of this study is to determine the effects of whether urgent or elective cesarean section on the occurrance of chronic pain.

Detailed description: The purpose of this study is to determine the effects of whether urgent or elective cesarean section on the occurrance of chronic pain. Patients aged between 18 - 45 years whose underwent urgent or elective cesarean section will be invited to participate in the study. Preoperatively in operating theatre, patients will be asked to complete the pain catastrophizing scale (PCS) questionnaire. In postoperative 6 months after discharge, patients will be called by an investigator who is blind to the study to evaluate the presence of chronic pain. Patients will be asked to grade the pain that they suffer using a numeric rating scale for the intensity of pain.

Eligibility criteria: Inclusion Criteria:

* Female
* 18 - 45 years of age
* underwent elective or urgent cesarean section

Exclusion Criteria:

* not willing to participate in the study
* can not reach by phone
* use of anti-psychotic or anti-depressant drugs

Primary outcomes:
measure: numeric rating scale
timeFrame: One time when calling the patient, an avarage of three months
Secondary outcomes:
measure: pain catastrophizing scale
timeFrame: one time in operating theatre, an avarage of three months
measure: presence of chronic pain using numeric rating scale
timeFrame: One time when calling the patient, an avarage of three months
Other outcomes:
Locations:
city: Tokat
country: Turkey
facility: Gaziosmanpasa University
Study officials:
affiliation: Gaziosmanpasa University
name: Hakan Tapar, Assist.Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00976664: Orthotic Use for Chronic Low Back Pain
Official title: Orthotic Use for Chronic Low Back Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Low Back Pain
Lead sponsor: National University of Health Sciences
Sponsor class: OTHER
Collaborators: name: Foot Levelers, Inc.
First posted: 2009-09-14
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this research study is to determine the change in perceived levels of pain and dysfunction in 50 patients with chronic low back pain, following the use of custom-made shoe orthotics for a three month period. The hypothesis of this study is that custom orthotic intervention will improve the patients' low back pain and dysfunction symptoms.


Eligibility criteria: Inclusion Criteria:

1. Males and females must be at least 18 years old.
2. Subjects must be symptomatic with current pain between T12 and the Sacroiliac joints with or without radiating pain.
3. Symptoms must have been present for at least three months.

Exclusion Criteria:

1. Use of custom-made shoe orthotics in the past year
2. Brain disorders (i.e.: dementia or Alzheimer's Disease) that would lead to difficulty in questionnaire completion.
3. Active conservative care (such as physical therapy or chiropractic care) for the low back received in the last six months (excluding the use of oral medications or daily at-home exercises for general well-being). We do not want to over-treat the patient or have any cross-over effects within this study from previous treatment.
4. Not fluent or literate in the English language. We will not be able to provide multiple translators within this pilot study.
5. Current or future litigation for low back pain.
6. Chronic pain other then low back pain such as fibromyalgia
7. Low back surgery in last six months.
8. Other conditions that may affect the outcomes of this study or exclude patients from participation in the study, including contraindications to orthotic use.
9. Peripheral neuropathy due to disorders such as diabetes.
10. Low back or leg pain that is not reproducible.

Primary outcomes:
measure: Visual Analog Scale (VAS)
timeFrame: Randomization, Week 6, and Week 12
measure: Oswestry Disability Index (ODI)
timeFrame: Randomization, Week 6, and Week 12
Secondary outcomes:
Other outcomes:
Locations:
city: Lombard
country: United States
facility: National University of Health Sciences
state: Illinois
Study officials:
affiliation: National University of Health Sciences
name: Jerrilyn Cambron, DC, MPH, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05928364: Buccal Mucosal Graft for Onlay Ureteroplasty in the Management of Proximal Ureteral Stricture
Official title: Buccal Mucosal Graft for Onlay Ureteroplasty in the Management of Proximal Ureteral Stricture
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Stricture Ureter
Keywords: Buccal mucosa
Stricture
ureteroplasty
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2023-07-03
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Patients with inclusion criteria of uretral stricture will be treated with open uretroplasty with buccal graft and omental wrapping
Primary purpose: TREATMENT

Brief summary: Onlay uretroplasty with either grafts or flaps has been attempted by many reconstructive urologists, ln particular buccal mucosa graft (BMG) ureteroplasty has been reported by many centers and has shown its feasibility and safety

Detailed description: In cases of long segment upper ureteral stricture, more advanced surgical techniques, such as renal mobilization and downward nephropexy, ileal ureter replacement, transureteroureterostomy, and autotransplantation of the kidney, are necessary to provide a tension-free anastomosis.

Autotransplantation of the kidney needs more efforts, more experts and may lead to significant renovascular complications.

Also, there is severe metabolic and intestinal complications are associated with using of long intestinal segment in the management of ureteral stricture \[9\].

These previous side effects and difficulties make the management of long upper and middle ureteral strictures more complicated and indicate other lines of management urgently.

Even the ureteral stricture still not patent enough to drain urine but still, we can use it as a ureteral plate with little affection of its vascularity. Based on this theory an onlay repair technique was emerged.

Onlay uretroplasty with either grafts or flaps has been attempted by many reconstructive urologists, ln particular buccal mucosa graft (BMG) ureteroplasty has been reported by many centers and has shown its feasibility and safety.

Eligibility criteria: Inclusion Criteria:

* Proximal ureteral stricture or uretropelvic junction obstruction (UPJO) which are not amenable for primery anastmosis.

Exclusion Criteria:

* Buccal graft contraindications as i. Active oral infections ii.Oral cancers like cancers of lips, tongue or cheeks.

Primary outcomes:
measure: Restoration of ureteric patency.
timeFrame: 6 months post-operative
Secondary outcomes:
measure: Pain relief after surgery
timeFrame: 6 months post-operative
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Urology department - AlAzhar university
Study officials:
References: