Clinical trial NCT00847743: Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation
Official title: Effects of Tart Cherry Juice on Oxidative Stress and Inflammation in Older Men and Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Oxidative Stress
Antioxidant Capacity
Inflammation
Keywords: oxidative stress
aging
ischemia-reperfusion
Lead sponsor: Kronos Longevity Research Institute
Sponsor class: OTHER
Collaborators: name: Vanderbilt University
First posted: 2009-02-19
Enrollment: 12
Sex: ALL
Minimum age (years): 55
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: Oxidative stress has been linked to many diseases associated with aging, including coronary heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work together to help prevent damage by free radicals. Some studies have indicated that as people age, they are less able to fight off oxidative stress and have increased levels of inflammation.

Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate and containing no additives and no preservatives.

We hope to learn whether antioxidant supplementation, such as tart cherry juice, can measurably decrease oxidative damage and inflammation associated with aging.

Detailed description: Objectives

The primary objective of this pilot study is to investigate whether tart cherry juice consumption can reduce oxidative stress in older adults as measured by attenuation of F2-isoprostane responses to a forearm ischemia-reperfusion, and a decrease in urinary excretion products of oxidative damage. The secondary objective is to examine whether age-sensitive markers of inflammation are reduced in response to the cherry juice consumption.

Eligibility criteria: Inclusion Criteria:

* men and women, ages 55-80y, in good health, with \>8 years of education
* non-smoker
* able to give informed consent

Exclusion Criteria:

* use of anti-oxidant supplements, in excess of a standard multi-vitamins
* current hormone replacement therapy
* any history of significant chronic disease
* uncontrolled hypertension
* body mass index (BMI) \> 30 kg/m2
* high physical activity level, as determined by questions on the screening questionnaire
* use of anti-inflammatory medication

Primary outcomes:
measure: plasma F2-isoprostane response to a forearm ischemia-reperfusion challenge.
Secondary outcomes:
measure: Urinary markers of oxidative damage.
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Kronos Longevity Research Institute
state: Arizona
Study officials:
affiliation: Kronos Longevity Research Institute
name: Tinna Traustadottir, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Traustadottir T, Davies SS, Stock AA, Su Y, Heward CB, Roberts LJ 2nd, Harman SM. Tart cherry juice decreases oxidative stress in healthy older men and women. J Nutr. 2009 Oct;139(10):1896-900. doi: 10.3945/jn.109.111716. Epub 2009 Aug 19.