Clinical trial NCT05868850: Application of Auricular Point Sticking in Patients With Taste Alteration
Official title: Study On The Application of Auricular Point Sticking Based On Holographic Theory In Chemotherapy-related Taste Alterations In Cancer Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dysgeusia
Acupressure
Chemotherapy Effect
Lead sponsor: Affiliated Hospital of Jiangnan University
Sponsor class: OTHER
First posted: 2023-05-22
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To explore the intervention effect of auricular point sticking on chemotherapy-induced taste alterations in cancer patients, and analyze its relationship with quality of life, nutritional status and psychology of patients.

Detailed description: Taste alteration is a common adverse reaction in patients with chemotherapy. The incidence of taste alteration varies with chemotherapy drugs, ranging from 36% to 84%, among which platinum chemotherapeutic drugs are most likely to cause severe taste alteration. The taste alteration does not pose a serious threat to the life of patients, so it is often ignored by patients and medical staff. Dysgeusia is positively correlated with the loss of appetite, which can directly lead to the loss of appetite and insufficient intake of nutrients in patients, and even stimulate patients' anxiety, psychological pain and other negative emotions. In severe cases, it can cause malnutrition, reduce the chemotherapy compliance of cancer patients, and ultimately reduce the quality of life of patients. Therefore, for patients with platinum chemotherapy, it is necessary to pay close attention to the change of taste during chemotherapy, and apply effective nursing interventions to pay attention as soon as possible, so as to improve the quality of life of patients.

Eligibility criteria: Inclusion Criteria:

1. Patients with malignant tumors diagnosed by histopathology or pathology;
2. Age ≥18 years old;
3. Patients who received platinum-based chemotherapy and completed at least one cycle of chemotherapy;
4. According to the chemotherapy-induced taste Changes Scale (CiTAS), the score of patients was ≥6;
5. Patients voluntarily participated in the treatment with good compliance and adherence.

Exclusion Criteria:

1. Patients with treatment plan adjustment or concurrent radiotherapy;
2. Patients with abnormal taste and malnutrition caused by various reasons before chemotherapy;
3. Patients with inflammation of the external ear or eczema, ulcers, chilblain in the pressing area;
4. Allergic or intolerant to adhesive stickers;
5. Those who were lost to follow-up or withdrew voluntarily;
6. Patients enrolled in other studies at the same time.

Primary outcomes:
measure: Taste alterations
timeFrame: T1: Baseline. T2:2 weeks. T3: 4 weeks. T4:5 weeks.
Secondary outcomes:
measure: Quality of life for cancer patients
timeFrame: T1: Baseline. T2:2 weeks. T3: 4 weeks. T4:5 weeks. T5:8 weeks.
measure: Anxiety and depression
timeFrame: T1: Baseline. T2:2 weeks. T3:4 weeks. T4:5 weeks. T5:8 weeks.
measure: Nutritional status 1
timeFrame: T1: baseline(Data were collected before the intervention). T2: 4 weeks. T3:8 weeks.
measure: Nutritional status 2
timeFrame: T1: baseline(Data were collected before the intervention). T2: 4 weeks. T3:8 weeks.
measure: Nutritional status 3
timeFrame: T1: baseline(Data were collected before the intervention). T2: 4 weeks. T3:8 weeks.
measure: Nutritional status 4
timeFrame: T1: baseline(Data were collected before the intervention). T2: 4 weeks.
Other outcomes:
Locations:
city: Wuxi
country: China
facility: Affiliated Hospital of Jiangnan University
state: Jiangsu
Study officials:
affiliation: Affiliated Hospital of Jiangnan University
name: Quan Liu, Doctor
role: STUDY_CHAIR
References: