Clinical trial NCT03818503: E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe
Official title: E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cancer
Lead sponsor: European Organisation for Research and Treatment of Cancer - EORTC
Sponsor class: NETWORK
First posted: 2019-01-28
Enrollment: 2000
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient with various tumor types planned to be treated with radiation therapy

Brief summary: The primary objective is the collection of real-world data of cancer patients treated with radiotherapy, to support radiotherapy research and to provide evidence of the role of radiation oncology in a multidisciplinary approach. This is an open ended prospective non-interventional non-therapeutic multi-cohort study.


Eligibility criteria: Inclusion Criteria:

* Pathologically confirmed cancer.
* Written informed consent for E²-RADIatE according to applicable legal and ethical requirements
* Planned use of radiotherapy
* Eligibility of the patient confirmed for at least one cohort confirmed
* Patients of 12 years and older

Primary outcomes:
measure: Number of patients treated with radiotherapy enrolled in the program
timeFrame: 5 years
Secondary outcomes:
measure: Disease free survival
timeFrame: 5 years
measure: Loco-regional control
timeFrame: 5 years
measure: Distant metastasis free survival
timeFrame: 5 years
measure: Overall survival
timeFrame: 5 years
measure: Incidence of adverse events related to radiotherapy
timeFrame: 5 years
Other outcomes:
Locations:
city: Graz
country: Austria
facility: Medical University of Graz - Radio-oncology
city: Linz
country: Austria
facility: Ordensklinikum Linz-Barmherzige Schwestern
city: Vienna
country: Austria
facility: Universitaetskliniken der Uni Wien - Universitaetsklinikum Wien - AKH unikliniken
city: Aalst
country: Belgium
facility: Onze Lieve Vrouw Ziekenhuis
city: Brussels
country: Belgium
facility: Cliniques Universitaires Saint-Luc
city: Brussels
country: Belgium
facility: Institut Jules Bordet
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent
city: Gent
country: Belgium
facility: AZ Sint-Lucas & Volkskliniek
city: Kortrijk
country: Belgium
facility: AZ Groeninge Kortrijk - Campus Kennedylaan
city: Leuven
country: Belgium
facility: U.Z. Leuven - Campus Gasthuisberg
city: Liege
country: Belgium
facility: C.H.U. Sart-Tilman
city: Namur
country: Belgium
facility: CHU Site Sainte-Elisabeth-UCL Namur
city: Turnhout
country: Belgium
facility: AZ Turnhout - Campus Sint Elisabeth
city: Wilrijk
country: Belgium
facility: GasthuisZusters Antwerpen - Sint-Augustinus
city: Hradec Kralove
country: Czechia
facility: University Hospital Hradec Kralove
city: Brest
country: France
facility: Clinique Pasteur-Lanroze (1174)
city: Aachen
country: Germany
facility: Universitaetsklinikum Aachen AOR - Medizinische Fakultaet der RWTH
city: Bayreuth
country: Germany
facility: Klinikum Bayreuth Gmbh
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus
city: Moenchengladbach
country: Germany
facility: Kliniken Maria Hilf GmbH
city: Muenchen
country: Germany
facility: Ludwig-Maximilians-Universitaet Muenchen - Campus Grosshadern
city: Dublin
country: Ireland
facility: St Luke Hospital & SLRON - SLRON - St. Luke'S Hospital Rathgar
city: Dublin
country: Ireland
facility: Beacon Hospital
city: Galway
country: Ireland
facility: University Hospital Galway
city: Ramat Gan
country: Israel
facility: Sheba Medical Center Tel Hashomer
city: Acquaviva delle Fonti
country: Italy
facility: Ente Ecclesiastico Ospedale Generale Regionale "F. Miulli"
city: Arezzo
country: Italy
facility: USL Toscana South East, Ospedale S. Donato
city: Brescia
country: Italy
facility: Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
city: Firenze
country: Italy
facility: Univ. of Florence -Azienda Ospedaliero-Universitaria Careggi
city: Milano
country: Italy
facility: IRCCS Ospedale San Raffaele
city: Milano
country: Italy
facility: Istituto Europeo di Oncologia
city: Milan
country: Italy
facility: Istituto Clinico Humanitas
city: Negrar
country: Italy
facility: Sacro Cuore Hospital
city: Negrar
country: Italy
facility: IRCCS Ospedale Sacro Cuore Don Calabria
city: Pavia
country: Italy
facility: Istituti Clinici Scientifici Maugeri
city: Pavia
country: Italy
facility: Centro Nazionale di Adroterapia Oncoloica par il trattamento dei tumori
city: Perugia
country: Italy
facility: San Maria della Misericordia Hospital
city: Roma
country: Italy
facility: Policlinico Universitario Campus Bio-Medico- Oncology Center
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario A. Gemelli - Fondazione Policlinico Universitario Agostino Gemelli IRCCS
city: Terni
country: Italy
facility: Azienda Ospedaliera Santa Maria di Terni
city: Torino
country: Italy
facility: Azienda Ospedaliera Citta della Salute e della Scienza di Torino - Universita Di Torino - San Giovanni Battista
city: Eindhoven
country: Netherlands
facility: Stichting Catharina Ziekenhuis
city: Groningen
country: Netherlands
facility: University Medical Center Groningen
city: Nijmegen
country: Netherlands
facility: Radboudumc - Radboud University Medical Center Nijmegen
city: Nijmegen
country: Netherlands
facility: Radiotherapiegroep Arnhem
city: Lodz
country: Poland
facility: Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi
city: Radom
country: Poland
facility: Kliniki Neuroradiochirurgii Sp. z o.o.-Radomskie Centrum Onkologii
city: Warsaw
country: Poland
facility: Maria Sklodowska-Curie Memorial Cancer Centre - Maria Sklodowska-Curie National Research Institute of Oncology
city: Ljubljana
country: Slovenia
facility: The Institute Of Oncology
city: Badalona
country: Spain
facility: ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia)
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron -Vall d'Hebron Institut Oncologia
city: Barcelona
country: Spain
facility: Hospital De La Santa Creu I Sant Pau
city: Cartagena
country: Spain
facility: Hospital General Universitario Santa Lucia
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia
city: Madrid
country: Spain
facility: Hospital Universitario Ramon y Cajal
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Madrid
country: Spain
facility: Hospitales HM Sanchinarro-CIOCC
city: Madrid
country: Spain
facility: Hospital Universitario de La Princesa
city: Madrid
country: Spain
facility: Hospital Universitario San Carlos
city: Pamplona
country: Spain
facility: Hospital Universitario de Navarra
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca (430)
city: Terrassa
country: Spain
facility: Hospital Consorci Sanitari De Terrassa
city: Valencia
country: Spain
facility: Hospital Clinico Universitario De Valencia
city: Valencia
country: Spain
facility: Hospital Universitario La Fe
city: Bern
country: Switzerland
facility: Inselspital
city: Chur
country: Switzerland
facility: Kantonsspital Graubuenden
city: Geneve
country: Switzerland
facility: Hôpitaux universitaires de Genève - HUG - site de Cluse-Roseraie
city: La Chaux-de-Fonds
country: Switzerland
facility: Reseau Hospitalier Neuchatelois - RHNe - La Chaux de Fonds
city: Sion
country: Switzerland
facility: Hopital du Valais - Hopital de Sion
city: Zürich
country: Switzerland
facility: UniversitaetsSpital Zurich
city: Aberdeen
country: United Kingdom
facility: NHS Grampian - Aberdeen Royal Infirmary
city: Cardiff
country: United Kingdom
facility: Velindre NHS Trust - Velindre Cancer Centre
city: Glasgow
country: United Kingdom
facility: NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital
city: Manchester
country: United Kingdom
facility: The Christie NHS Foundation trust - The Christie NHS Foundation Trust
city: Sheffield
country: United Kingdom
facility: Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital
city: Taunton
country: United Kingdom
facility: Somerset NHS Foundation Trust-Musgrove Park Hospital
city: Wirral
country: United Kingdom
facility: The Clatterbridge cancer Center NHS foundation Trust - Clatterbridge Cancer Center - Wirral
Study officials:
References: