Clinical trial NCT03015350: Blood Levels of Sevoflurane and Desflurane
Official title: Blood Levels of Sevoflurane and Desflurane During One Lung Ventilation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthetics, Inhalation
Keywords: blood sevoflurane concentration
blood desflurane concentration
one lung ventilation
Lead sponsor: Cukurova University
Sponsor class: OTHER
First posted: 2017-01-10
Enrollment: 16
Sex: ALL
Minimum age (years): 25
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 16 patients with ASA I-III who undergo thoracotomy or abdominal surgery

Brief summary: 16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D. Each groups will divide 2 subgroups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. At the time point 40.minutes first blood sample will given from patients. Blood sample will be taken at intervals of 10 minutes from groups of two lung ventilation. In groups of one lung ventilation, blood samples will be taken at the time interval of 10 minutes after one lung ventilation started. All blood samples will be assess in Gas Chromatography.

Detailed description: Investigator aimed to assess blood level of sevoflurane and desflurane during two lung ventilation and one lung ventilation. The investigators will use Gas Chromatography for define drugs levels. 16 patients with ASA I-III patients who undergo thoracotomy and abdominal surgery will be recruited to this study. Patients will divided in to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D during anesthesia maintenance. Each groups will divide 2 subgroups which are one lung ventilation groups and two lung ventilation groups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. Sequential blood samples will be taken from both arterial and central venous canula at the same time point. First blood samples will be taken at 40. minutes of anesthesia. Sequential samples will be taken at interval of 10 minutes during two lung ventilation. In one lung ventilation second blood samples will be taken at the 10. minutes of one lung ventilation. After than at the interval of 10 minutes, collection of blood samples both arterial and central venous will be continue.

All collection will assess with gas chromatography.

Eligibility criteria: Inclusion Criteria: ASA I-II patients

* Who undergo thoracotomy or abdominal surgery

Exclusion Criteria:

* ASA IV and up patients
* Patients who taken inotropic agent

Primary outcomes:
measure: Measurement of blood levels of Sevoflurane and Desflurane
timeFrame: from 40th minute to the end of the operation
Secondary outcomes:
measure: determine of ventilation-perfusion mismatch with p(A-a)O2
timeFrame: from 40th minute to the end of the one lung ventilation
Other outcomes:
Locations:
city: Adana
country: Turkey
facility: Ebru Biricik
state: In The USA Or Canada, Please Select...
Study officials:
affiliation: Cukurova University
name: Ebru Biricik, MD
role: PRINCIPAL_INVESTIGATOR
References: