Clinical trial NCT06133764: Different Modalities of Management of Odontogenic Keratocysts
Official title: Analysis of Odontogenic Keratocyst Treated With Various Modalities Over a 10-year
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Odontogenic Cysts
Keywords: Odontogenic cysts
Odontogenic Keratocysts
Lead sponsor: Qassim University
Sponsor class: OTHER
Collaborators: name: Al-Azhar University
First posted: 2023-11-15
Enrollment: 50
Sex: ALL
Minimum age (years): 10
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The patents will be divided into five groups according to the treatment modalities used to treat their odontogenic cysts
Primary purpose: TREATMENT

Brief summary: Background The odontogenic keratocysts (OKCs) have been one of the maxillofacial region's most contentious pathological phenomena. Decompression/marsupialization (D/M), enucleation (E), enucleation + chemical cauterization with Carnoy's solution (E+CS), enucleation + peripheral ostectomy (E + PO), as opposed to enucleation + chemical cauterization with Carnoy's solution + peripheral ostectomy (E + CS + PO), were used during surgery to ensure that no epithelial remnants were left behind.

Rationale Through the management of OKC a recurrence could occur, the effectiveness of Decompression/marsupialization (D/M), Enucleation (E), Enucleation+Carnoy's solution chemical cauterization (E+CS), Enucleation+peripheral ostectomy (E+PO), Enucleation+Carnoy's solution chemical cauterization + peripheral ostectomy (E+CS + PO), will be analyzed

Detailed description: Since the middle of the 20th century, the odontogenic keratocyst (OKC) has been one of the maxillofacial region's most contentious pathological phenomena. It was initially misdiagnosed as a primordial cyst. After that, because of its severe clinical behavior and tendency to recur, it was no longer considered to be a part of its classification, also known as a odontogenic tumor. Then, In 2017, the OKC are re-classified as a cystic lesion. But still there is debate about their management. So, this study will be enrolled with the following objectives: to describe how odontogenic keratocysts are managed, to Discover the most favorable approach to manage OKC with the need to stop it from happening again To categorize the odontogenic keratocyst management outcomes into to the subsequent groups: (1) total resolution, (2) partial resolution; (3) Recurrence.

Eligibility criteria: Inclusion Criteria:

* All odontogenic keratocysts that are treated by the following surgical treatment modalities:

  1. Enucleation followed by peripheral ostectomy and Carnoy's solution
  2. Decompression/ marsupialization
  3. Enucleation
  4. Enucleation and Carnoy's solution
  5. Enucleation and Peripheral Ostectomy
* Follow-up period 10 years

Exclusion Criteria:

* Cases treated with resection
* Cases showed neoplastic transformation in their pathology
* Cyst Like lesions

Primary outcomes:
measure: Healing period
timeFrame: Starting from the postoperative third month up to the postoperative ninth month
measure: Measurement of the bony cavity
timeFrame: At the end of the postoperative ninth month
measure: Recurrence rate
timeFrame: At the end of the postoperative fifth year
measure: Recurrence rate
timeFrame: At the end of the postoperative tenth year
Secondary outcomes:
Other outcomes:
Locations:
city: Buraydah
country: Saudi Arabia
facility: College of Dentistry, Qassim University
state: Qassim Region
Study officials:
affiliation: College of Dentistry, Qassim University, Saudi Arabia
name: Ghada A Khalifa, Professor
role: PRINCIPAL_INVESTIGATOR
References: