Clinical trial NCT03346408: Dependence on Analgesics in Chronic Non-cancer Pain
Official title: Dependence on Analgesics in Chronic Non-cancer Pain: Comparison of the Perceptions of the Algologist Physician and the Perception of the Patient.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pain, Chronic
Keywords: Analgesics
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2017-11-17
Enrollment: 220
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Physician and patients recruited in pain consultations and treatment structures

Brief summary: The identification of an addiction to opioid analgesics has become strong recommendation for the purpose of improving the clinical management of the patients. However, the success of the patient's clinical management, in terms of analgesia and treatment of drug dependence, rests on the acceptance of this management by the patient himself. The main objective of this study is to evaluate the factors associated to the discrepancy between the assessment of dependence on analgesic drugs by the algologist and the perception that the patient with non-cancer chronic pain has of this dependence.

Detailed description: The long-term use of opioid analgesics for the treatment of chronic non-cancer pain exposes patients to the risk of developing drug dependence on these psychoactive drugs with loss of control of their use. In general medicine as well as in algology consultation, the identification of an addiction to opioid analgesics (and even misuse as a gateway to addiction) have thus become strong recommendations for the purpose of improving the management of the patients. However, the success of the patient's clinical management, in terms of analgesia and treatment of drug dependence, rests on the acceptance of this management by the patient himself.

The discrepancy between the assessment of drug dependence on analgesic drugs by the algologist and the perception that the patient has of this dependence will be investigated through a multicentre cross-sectional descriptive survey performed in pain treatment centres in France.

In addition to opioid analgesics, other pharmacological classes used for analgesic use will be investigated as they are concerned with the development of drug dependence. This is particularly the case for gabapentins.

Eligibility criteria: Inclusion Criteria:

* suffering from chronic non-cancer pain,
* taking at least one analgesic medication

Exclusion Criteria:

* Patient minor or major protected by the law (under tutelage),
* Patient with chronic pain of cancerous origin,
* Opposition of the patient to be included in the study,
* Patient not having the overall skills to complete a self-questionnaire: major difficulties in understanding the French language and / or reading / writing difficulties.

Primary outcomes:
measure: discrepancy between the assessment of dependence on analgesic drugs by the algologist and the perception of the patient
timeFrame: Baseline
Secondary outcomes:
measure: Consumption drugs
timeFrame: Baseline
measure: Anxiety
timeFrame: Baseline
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: University Hospital Bordeaux
city: Clermont-Ferrand
country: France
facility: University Hospital Clermont-Ferrand
city: Limoges
country: France
facility: University Hospital Limoges
city: Marseille
country: France
facility: University Hospital Marseille
city: Montpellier
country: France
facility: University Hospital Montpellier
city: Nice
country: France
facility: University Hospital Nice
city: Toulouse
country: France
facility: University HospitalToulouse
Study officials:
affiliation: University Hospital, Toulouse
name: Anne ROUSSIN, PharmD PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Roussin A, Cisse Z, Rousseau V, Roche G, Lestrade C, Cauchie A, Delage N, Donnet A, Van Obberghen E, Wood C, Lapeyre-Mestre M, Cantagrel N. Discordance between pain specialists and patients on the perception of dependence on pain medication: A multi-centre cross-sectional study. Therapie. 2024 Sep-Oct;79(5):543-551. doi: 10.1016/j.therap.2024.01.008. Epub 2024 Apr 12.