Clinical trial NCT06754579: Impact of High-Volume Upper Limb Training on Physical and Cognitive Outcomes
Official title: Effect of High-Volume Upper Extremity Exercises on Physical and Cognitive Performance in Sedentary Adults
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Sedentary Behavior
Keywords: upper limb
reaction time
pyhsical performance
cognitive performance
Lead sponsor: Tarsus University
Sponsor class: OTHER
First posted: 2025-01-01
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The study was planned as a randomized controlled study
Primary purpose: TREATMENT

Brief summary: Engaging in regular and appropriately structured physical activities is a critical component of an individual's lifestyle and represents a lifelong habit essential for promoting overall well-being. Research increasingly emphasizes the significance of such activities, particularly in the prevention and management of various health conditions (Martin, Richardson, Weiller, \& Jackson, 2004).A sedentary lifestyle is considered one of the most serious health issues faced by individuals in the modern world.Previous research has established high-intensity interval training (HIIT) as an effective method for enhancing cardiovascular health, sparking interest in the relationship between exercise intensity and cognitive function. Most studies to date have focused on treadmill and lower extremity ergometer exercises; however, evidence regarding the efficacy of high-volume upper extremity exercises in improving physical and cognitive performance among sedentary adults remains limited and inconsistent. Upper extremity motor function has been proposed as a potential biomarker for cognitive impairment and may contribute to distinguishing healthy aging trajectories. This study aims to compare the effects of high-volume and low-volume upper extremity exercise in sedentary adults, testing the hypothesis that one exercise regimen may be superior in enhancing both physical and cognitive performance, as well as cognitive function.

Detailed description: Engaging in regular, well-structured physical activities is a cornerstone of a healthy lifestyle and constitutes a lifelong habit essential for sustaining overall health and well-being. Such activities have been increasingly recognized for their vital role in preventing and managing a wide range of health conditions, emphasizing their importance for both physical and mental health (Martin, Richardson, Weiller, \& Jackson, 2004). Conversely, a sedentary lifestyle has emerged as one of the most pressing public health challenges of the modern era, contributing significantly to the global burden of disease and highlighting the need for effective intervention strategies.

Among these strategies, high-intensity interval training (HIIT) has gained widespread attention for its efficacy in improving cardiovascular health. This has, in turn, sparked growing interest in understanding the broader impact of exercise intensity, particularly its effects on cognitive function. However, much of the existing research has concentrated on lower extremity exercises, such as those performed on treadmills or ergometers, leaving a significant gap in the understanding of the benefits of upper extremity exercises. The role of high-volume upper extremity exercise in enhancing both physical and cognitive performance remains underexplored, with current evidence presenting inconsistent and conflicting findings.

Notably, upper extremity motor function has been identified as a promising biomarker for cognitive impairment. Its assessment may provide critical insights into distinguishing healthy aging trajectories from pathological cognitive decline. This connection underscores the potential importance of upper extremity exercises as a tool for both physical and cognitive health maintenance in sedentary populations.

The present study aims to address these gaps by comparing the effects of high-volume and low-volume upper extremity exercise regimens on sedentary adults. Specifically, the research seeks to test the hypothesis that one of these exercise modalities may offer superior benefits in enhancing physical performance, cognitive performance, and overall cognitive function. By investigating these relationships, the study aims to contribute to the growing body of evidence on exercise-based interventions, offering novel insights into strategies for optimizing health outcomes in sedentary individuals.

Eligibility criteria: Inclusion Criteria:

* Individuals aged between 18-50 years.
* Defined as engaging in less than 150 minutes of moderate-intensity physical activity per week

Exclusion Criteria:

* diagnosis of neurological, cardiovascular, musculoskeletal, or other systemic diseases that may affect physical activity or exercise capacity.
* diagnosed cognitive impairments or psychiatric disorders that could interfere with test participation.
* acute injuries or surgeries within the past six months that could restrict movement or participation.

Primary outcomes:
measure: International Physical Activity Questionnaire-Short Form (IFQQ-SF)
timeFrame: eight weeks
Secondary outcomes:
measure: Maximal Arm Exercise Capacity
timeFrame: Eight weeks
measure: Stroop Test
timeFrame: Eight weeks
measure: Reaction Time
timeFrame: Eight weeks
measure: Hole Type Steadiness Tester
timeFrame: Eight weeks
measure: Postural Sway Assessment
timeFrame: Eight weeks
measure: Upper Extremity Muscle Strength Assessment
timeFrame: Eight weeks
Other outcomes:
Locations:
city: Tarsus
country: Turkey
facility: Fatma Kübra Çekok
state: Mersi̇n
Study officials:
References: