Clinical trial NCT06464302: Investigation of the Effect of Age and Injury Severity on Short-term Intra-hospital Outcomes After Surgical Stabilized Rib Fractures
Official title: Investigation of the Effect of Age and Injury Severity on Short-term Intra-hospital Outcomes After Surgical Stabilized Rib Fractures
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Rib Fractures
Rib Trauma
Rib Fracture Multiple
Thorax; Fracture
Keywords: Surgical stabilisation of rib fractures (SSRF)
Lead sponsor: University Hospital Muenster
Sponsor class: OTHER
First posted: 2024-06-18
Enrollment: 700
Sex: ALL
Minimum age (years): 0
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The Patients will be sampled from all patients treated in the department for trauma, hand and reconstructive surgery of the university hospital Muenster

Brief summary: The study aims to investigate the effect of surgical stabilisation of rib fractures (SSRF) on clinical outcomes measured during the hospital stay (mortality, days on a mechanical ventilator, intensive care unit and hospital length of stay, rate of complications). Furthermore, the effect of the patients age and overall injury severity on the outcomes after SSRF will be investigated. We hypothesise that the combination of high age and high injury severity will lead to worse outcomes after SSRF.


Eligibility criteria: Inclusion Criteria:

* Patients of the University Hospital Muenster
* Coded serial rib fractures (ICD S22.4 and S22.5)
* Treatment for the rib fractures between 2019 and 2023

Exclusion Criteria:

* pathological rib fractures (due to suspected malignancy)

Primary outcomes:
measure: In hospital-mortality
timeFrame: From injury up to initial hospital discharge or death, whichever came first, assessed up to 2 month.
measure: Intensive care unit length of stay
timeFrame: From injury up to initial hospital discharge or death, whichever came first, assessed up to 2 month.
Secondary outcomes:
measure: Intubation rate
timeFrame: From injury up to initial hospital discharge or death, whichever came first, assessed up to 2 month.
measure: Multi-organ failure
timeFrame: From injury up to initial hospital discharge or death, whichever came first, assessed up to 2 month.
measure: Single organ failure
timeFrame: From injury up to initial hospital discharge or death, whichever came first, assessed up to 2 month.
measure: Sepsis
timeFrame: From injury up to initial hospital discharge or death, whichever came first, assessed up to 2 month.
measure: Lung-failure
timeFrame: From injury up to initial hospital discharge or death, whichever came first, assessed up to 2 month.
measure: Clinical outcome
timeFrame: At the time point of initial hospital discharge or at death, whichever came first, assessed up to 2 month.
measure: Duration of hospital stay
timeFrame: From injury up to initial hospital discharge or death, whichever came first, assessed up to 2 month.
Other outcomes:
Locations:
city: Münster
country: Germany
facility: Department for trauma, hand and reconstructive surgery, University hospital Muenster
state: NRW
Study officials:
affiliation: Department for trauma, hand and reconstructive surgery, University hospital Muenster
name: Steffen Rosslenbroich, PD Dr. med.
role: STUDY_DIRECTOR
References: