Clinical trial NCT06462404: A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1
Official title: A Randomized, Double-Blind, Single-Dose, 5-Period Crossover Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Subjects With Narcolepsy Type 1
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Narcolepsy Type 1 (NT1)
Keywords: Narcolepsy
E2086
Lead sponsor: Eisai Inc.
Sponsor class: INDUSTRY
First posted: 2024-06-17
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The primary purpose of this study is to evaluate the efficacy of single oral doses of E2086 compared to placebo in the treatment of excessive daytime sleepiness (EDS) as assessed by the Maintenance of Wakefulness Test (MWT) in adult participants with narcolepsy type 1 (NT1).


Eligibility criteria: Inclusion Criteria:

1. Male or female, age greater than or equal to (\>=) 18 years at the time of informed consent
2. Diagnosis of NT1 defined by the following criteria:

   * History of daily periods of the irrepressible need to sleep, or daytime lapses into sleep, occurring for at least 3 months
   * History of cataplexy (which must be confirmed during the Screening Period by Sleep/Cataplexy Diary)
   * At least one of the following:

     * On Screening multiple sleep latency test (MSLT): MSL of less than or equal to (\<=) 8 minutes and 2 or more sleep onset rapid eye movement periods (SOREMPs) on an MSLT performed according to standard techniques
     * On Screening nocturnal polysomnography (PSG): One or more SOREMPs within 15 minutes of sleep onset
3. Epworth Sleepiness Scale score \>=10
4. Reports regular bedtime, defined as the time that the participant attempts to sleep, between 22:00 and midnight (based on data from the Screening Sleep/Cataplexy Diary)
5. Reports regular waketime, defined at the time the participant gets out of bed for the day, between 05:00 and 10:00 (based on data from the Screening Sleep/Cataplexy Diary)
6. Reports being in bed between 7 and 9 hours per night (based on data from the Screening Sleep/Cataplexy Diary)
7. Body mass index (BMI) \>=18 to less than (\<) 40 kilograms per meter square (kg/m\^2), at Screening

Exclusion Criteria

1. Females who are breastfeeding or pregnant at Screening or Baseline (as documented by a positive beta-human chorionic gonadotropin \[ß-hCG\] or human chorionic gonadotropin \[hCG\] test with a minimum sensitivity of 25 international units per liter (IU/L) or equivalent units of ß-hCG \[or hCG\]), and females who are breastfeeding or pregnant during the Treatment Period. A separate baseline assessment is required if a negative screening pregnancy test was obtained more than 72 hours before the 1st dose of study drug
2. Females of childbearing potential who:

   * Within 28 days before study entry, did not use a highly effective method of contraception, which includes any of the following:

     * total abstinence (if it is their preferred and usual lifestyle)
     * a nonhormonal intrauterine device (example, "coil") or a progesterone-only intrauterine hormone-releasing system
     * a nonsteroidal oral contraceptive (participant must have been on a stable dose of the same nonsteroidal oral contraceptive product for at least 28 days before dosing and must agree to stay on the same dose of the oral contraceptive throughout the study and for 28 days after study drug discontinuation.)
     * depot medroxyprogesterone acetate or depot norethisterone enantate.
     * have a vasectomized partner with confirmed azoospermia.
   * Do not agree to use a highly effective method of contraception (as described above) throughout the entire study period and for 30 days after study drug administration.

     * Participants on an oral contraceptive must use an additional barrier method throughout the study and for 30 days after study drug administration.

   NOTE: All females will be considered to be of childbearing potential unless they are postmenopausal (amenorrheic for at least 12 consecutive months, in the appropriate age group, and without other known or suspected cause) or have been sterilized surgically (that are, bilateral tubal ligation, total hysterectomy, or bilateral oophorectomy, all with surgery at least 1 month before dosing).
3. Males who have not had a successful vasectomy (confirmed azoospermia) if their female partners meet the exclusion criteria above that is, the female partners are of childbearing potential and are not willing to use a highly effective contraceptive method throughout the study period and for 92 days after study drug administration. No sperm donation is allowed during the study period and for 92 days after study drug administration
4. History of myocardial infarction, ischemic heart disease, or cardiac failure at Screening
5. History of clinically significant arrhythmia or uncontrolled arrhythmia
6. Known to have or probable positivity for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within 14 days of any study visit.
7. Exposure within the last 10 days to an individual with confirmed or probable coronavirus disease-2019 (COVID-19) or symptoms within the last 10 days that are on the most recent Centers for Disease Control and Prevention (CDC) list of COVID symptoms
8. Hypersensitivity to excipients of the study drug (E2086), or to active comparator or any of its excipients
9. Any suicidal ideation with intent with or without a plan at Screening or within 6 months of Screening (that is, answering "Yes" to questions 4 or 5 on the Suicidal Ideation section of the CSSRS)
10. Any lifetime suicidal behavior (per the Suicidal Behavior section of the C-SSRS)
11. Any history of psychiatric disease (including but not limited to depression or other mood disorders, bipolar disorder, psychotic disorders, including schizophrenia, panic attacks, anxiety disorders), within 10 years of Screening
12. Any current psychiatric symptoms as indicated by a standard screening tool (Diagnostic and Statistical Manual of Mental Disorders \[DSM-5\] Self-Rated Level 1 Cross-Cutting Symptom Measure - Adult)
13. Participants with one or more 1st degree (blood) relatives who have lifetime diagnosis of bipolar type I disorder or a psychotic disorder
14. Psychotic disorder(s) or unstable recurrent affective disorder(s) evident by use of antipsychotics within 2 years before Screening
15. Evidence of clinically significant disease (examples, allergies; cardiac, respiratory, gastrointestinal, renal disease) that in the opinion of the investigator(s) could affect the participant's safety or interfere with the study assessments.
16. Any clinically abnormal symptom or organ impairment found by medical history, physical examinations, vital signs, ECG finding, or laboratory test results that require medical treatment at Screening or Baseline
17. Any history of or concomitant medical condition that in the opinion of the investigator(s) would compromise the participant's ability to safely complete the study.
18. History of drug or alcohol dependency or abuse within 2 years before Screening
19. Use of illegal recreational drugs at Screening and throughout the study
20. Intake of herbal preparations containing St. John's Wort within 4 weeks before dosing
21. Currently enrolled in another clinical study or used any investigational drug or device within 28 days or 5\* the half-life, (whichever is longer) preceding informed consent.
22. Evidence of disease that may influence the outcome of the study within 4 weeks before dosing (examples, psychiatric disorders and disorders of the gastrointestinal tract, liver, kidney, respiratory system, endocrine system, hematological system, neurological system, or cardiovascular system)
23. History of formally diagnosed moderate to severe obstructive sleep apnea, current use of continuous positive airway pressure, or symptomatic restless legs syndrome
24. Apnea-hypopnea index \>=15 on Screening PSG
25. Periodic limb movement arousal index (PLMAI)\>=15 on Screening PSG
26. Use of anti-cataplectic medications within 5\* the half-life before Screening
27. Use of psychostimulant medications, prescription and over-the-counter (OTC), within 5\*the half-life before Screening

    - Examples of prohibited medications include OTC stimulants (example, pseudoephedrine), methylphenidate, amphetamines, modafinil, armodafinil, sodium oxybate, and pemoline
28. Use of sleep promoting medications, prescription and OTC, within 28 days or 5\*the half-life before Screening - Examples of prohibited medication include OTC sleep aids, trazodone, hypnotics, benzodiazepines, barbiturates, cannabinoids, and opioids.

Primary outcomes:
measure: Mean Sleep Latency (MSL) as Assessed by the 4 Maintenance of Wakefulness Tests (MWTs) for E2086 Versus Placebo at Day 1
timeFrame: At Day 1
measure: MSL as Assessed by the 4 MWTs for E2086 Versus Placebo at Day 5
timeFrame: At Day 5
measure: MSL as Assessed by the 4 MWTs for E2086 Versus Placebo at Day 9
timeFrame: At Day 9
measure: MSL as Assessed by the 4 MWTs for E2086 Versus Placebo at Day 13
timeFrame: At Day 13
measure: MSL as Assessed by the 4 MWTs for E2086 Versus Placebo at Day 17
timeFrame: At Day 17
Secondary outcomes:
measure: MSL as Assessed by the 4 MWTs for E2086 Versus Active Comparator
timeFrame: Days 1, 5, 9, 13 and 17
measure: Karolinska Sleepiness Scale (KSS) Score for E2086 Versus Active Comparator
timeFrame: Day 1 up to Day 18
measure: KSS Score for E2086 Versus Placebo
timeFrame: Day 1 up to Day 18
measure: Number of Participants With Treatment-emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs)
timeFrame: From first dose of study drug up to Day 20
measure: Number of Participants With Markedly Abnormal Clinical Laboratory Values
timeFrame: Baseline up to Day 20
measure: Number of Participants With Markedly Abnormal Vital Sign Values
timeFrame: Baseline up to Day 20
measure: Number of Participants With Markedly Abnormal Electrocardiogram (ECGs) Findings
timeFrame: Baseline up to Day 20
measure: Number of Participants With Markedly Abnormal Electroencephalogram (EEGs) Findings
timeFrame: Baseline up to Day 20
measure: Number of Participants With Suicidality as Assessed by Columbia - Suicide Severity Rating Scale (C-SSRS)
timeFrame: Baseline up to Day 20
measure: Cmax: Maximum Observed Plasma Concentration of E2086 and its Metabolite M1
timeFrame: Days 1, 5, 9, 13 and 17: 0-24 hours post-dose
measure: Tmax: Time to Reach Cmax of E2086 and its Metabolite M1
timeFrame: Days 1, 5, 9, 13 and 17: 0-24 hours post-dose
measure: AUC(0-t): Area Under the Plasma Concentration-time Curve From Zero Time to Time of Last Quantifiable Concentration of E2086 and its Metabolite M1
timeFrame: Days 1, 5, 9, 13 and 17: 0-24 hours post-dose
measure: AUC(0-inf): Area Under the Plasma Concentration-time Curve From Zero Time Extrapolated to Infinite of E2086 and its Metabolite M1
timeFrame: Days 1, 5, 9, 13 and 17: 0-24 hours post-dose
measure: t½: Terminal Phase Half-life of E2086 and its Metabolite M1
timeFrame: Days 1, 5, 9, 13 and 17: 0-24 hours post-dose
measure: MRp: Metabolite Ratio of AUC(0-inf)
timeFrame: Days 1, 5, 9, 13 and 17: 0-24 hours post-dose
Other outcomes:
Locations:
city: Santa Ana
country: United States
facility: SDS Clinical Trials
state: California
city: Miami
country: United States
facility: PharmaDev Clinical Research
state: Florida
city: Macon
country: United States
facility: Sleep Practioners, LLC
state: Georgia
city: Stockbridge
country: United States
facility: Clinical Research Institute
state: Georgia
city: Lansing
country: United States
facility: Sound Asleep Research, Inc.
state: Michigan
city: Denver
country: United States
facility: Research Carolina Elite
state: North Carolina
city: Goldsboro
country: United States
facility: Medical Care Inc.
state: North Carolina
city: Greensboro
country: United States
facility: Advances Repiratory and Sleep Medicine
state: North Carolina
city: Cincinnati
country: United States
facility: Intrepid Research, LLC
state: Ohio
city: Columbia
country: United States
facility: Bogan Sleep Consultants, LLC
state: South Carolina
city: San Antonio
country: United States
facility: Sleep Therapy and Research Center
state: Texas
city: Sugar Land
country: United States
facility: Comprehensive Sleep Medicine Associates
state: Texas
city: Markham
country: Canada
facility: AMDX Inc.
state: Ontario
city: Toronto
country: Canada
facility: Jodha Tishon Inc
state: Ontario
Study officials:
References: