louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT07023068: ⁶⁸Ga-DPA in the Lung Cancer Diagnosis
Official title: Clinical Application of PD-L1 Targeted Imaging Agent ⁶⁸Ga-DPA in the Diagnosis of Lung Cancer
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: EARLY_PHASE1
Conditions: Lung Cancers
Keywords: PD-L1
lung cancer
PET/CT
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2025-06-15
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: In previous studies, we synthesized a PD-L1-targeted molecular probe, ⁶⁸Ga-DPA, and developed a ⁶⁸Ga-DPA injection for clinical research. Preliminary studies demonstrated its favorable safety profile and excellent imaging performance. Leveraging the established strengths of the Department of Nuclear Medicine at Peking Union Medical College Hospital, we now plan to conduct an exploratory PET/CT imaging study in lung cancer patients. This study aims to provide an in vivo, non-invasive, and visualizable technique for detecting PD-L1 expression levels and spatial distribution in tumors. It will further validate the clinical utility of this technology, offering critical diagnostic insights for initial assessment and treatment efficacy evaluation in PD-L1-positive tumor patients undergoing PD-L1-targeted therapies.


Eligibility criteria: Inclusion Criteria:

* Age ≥18 years, regardless of gender.
* Patients clinically confirmed or suspected of lung cancer, with pathological specimens obtainable via biopsy or surgery within the recent 2 months.
* At least one measurable target lesion according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.
* Expected survival \>3 months.

Exclusion Criteria:

* Severe hepatic or renal dysfunction (serum creatinine \>3.0 mg/dL or any liver enzyme level ≥5× upper limit of normal).
* Women who are planning pregnancy, pregnant, or breastfeeding.
* Inability to lie supine for 30 minutes.
* Claustrophobia or other psychiatric disorders.
* Intolerance to any clinical procedures in the study.
* Other conditions deemed ineligible by the investigator.

Primary outcomes:
measure: SUV
timeFrame: 0-180 minutes post-injection
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: 100730
Study officials:
affiliation: Peking Union Medical College Hospital
name: Zhaohui Zhu
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03800368: Exercise and Overnight Motor Sequence Task
Official title: 12-week Aerobic-Anaerobic Transition Exercise Intervention and Overnight Sleep-dependent Procedural Memory Consolidation in Patients With Schizophrenia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Schizophrenia and Related Disorders
Psychotic Disorders
Keywords: Exercise
Sleep-dependent memory consolidation
Aerobic
Anaerobic
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2019-01-11
Enrollment: 51
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.


Eligibility criteria: Inclusion Criteria:

* Aged from 18 to 55
* Based on the SCID diagnosed to have schizophrenia and related psychotic disorders
* Ability to understand the nature of the study and to give written informed consent

Exclusion Criteria:

* Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise may be contraindicated), and seizure disorders
* Comorbid substance dependence
* Unstable psychotic symptoms
* A history of brain trauma or organic brain disease
* Known history of intellectual disability or special school attendance
* Answered one or more "yes" in the PAR-Q and without doctors approval for exercise

Primary outcomes:
measure: The sleep-dependent procedural memory consolidation after 12 weeks of intervention
timeFrame: 12-week Follow-up
Secondary outcomes:
measure: The verbal memory consolidation after 12 weeks of intervention
timeFrame: 12-week Follow-up
measure: The attention performance after 12 weeks of intervention
timeFrame: 12-week Follow-up
measure: The sleep quality after 12 weeks of intervention
timeFrame: 12-week Follow-up
measure: The insomnia severity after 12 weeks of intervention
timeFrame: 12-week Follow-up
Other outcomes:
Locations:
Study officials:
affiliation: The University of Hong Kong
name: Lik Hang Lincoln Lo
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00668668: Dermatological Evaluation of Topic Compatibility-Dermacyd Tina Gel Sweet Flower
Official title: Study for Dermatological Evaluation of Topic Compatibility (Primary and Accumulated Dermical Irritability, Dermical Sensitivity) of Dermacyd Tina Gel Sweet Flower.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Hygiene
Lead sponsor: Sanofi
Sponsor class: INDUSTRY
First posted: 2008-04-29
Enrollment: 52
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to demonstrate the absence of irritation potential (primary dermic irritability and cumulated dermic irritability) and allergy (sensibilization) of the product Dermacyd Tina Gel Sweet Flower.


Eligibility criteria: Inclusion Criteria:

* Phototype Skin I,II, III e IV
* Integral skin test in the region

Exclusion Criteria:

* Lactation or gestation
* Use of Antiinflammatory and/or immunosuppression drugs
* Personnel history of atopy
* History of sensitivity or irritation for topic products
* Active cutaneous disease
* Use of new drugs or cosmetics during the study

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Primary outcomes:
measure: The absence of primary and accumulated dermal irritability and dermal sensitivity will be evaluated using International Contact Dermatitis Research Group (ICDRG) scale.
timeFrame: six weeks
Secondary outcomes:
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Sanofi-aventis
Study officials:
affiliation: Sanofi-aventis administrative office Brazil
name: Jaderson Lima
role: STUDY_DIRECTOR
References:
Clinical trial NCT02235168: Effect of Rollator on Walking Distance in Elderly Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Elderly
Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2014-09-09
Enrollment: 50
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: To evaluate the effect of a rollator on 6 Minute Walking Test (6MWT) in elderly people.


Eligibility criteria: Inclusion Criteria:

* elderly people (older than 60 years)

Exclusion Criteria:

* respiratory diseases

Primary outcomes:
measure: six minute walking test
timeFrame: 6 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Cliniques universitaires Saint-Luc
Study officials:
References:
Clinical trial NCT06438068: Influence of Modern Colon Hydrotherapy on Intestinal Transit
Official title: Influence of Modern Colon Hydrotherapy on Intestinal Transit
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Constipation - Functional
Hydrotherapy
Functional Colonic Diseases
Keywords: constipation
internal hydrotherapy
Radiopaque Media
Functional Colonic Diseases
Lead sponsor: Universidad Complutense de Madrid
Sponsor class: OTHER
First posted: 2024-05-31
Enrollment: 30
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A randomised and controlled trial, in which the effect of Modern Colon Hydrotherapy is evaluated in the gastrointestinal transit of subjects with functional constipation

Detailed description: The aim of the present randomized randomised and controlled trial is to evaluate the effect of Modern Colon Hydrotherapy in the gastrointestinal transit of subjects with functional constipation.

Two intervention groups were used, to which this type of treatment was applied and to which the intake of a product with prebiotic and prebiotic properties or a placebo was added, depending on the assigned group.

Eligibility criteria: Inclusion Criteria:

* Patients between 20 and 60 years of age with functional constipation of more than 5 years of evolution.

Exclusion Criteria:

* Taking any type of antibiotic in the last month
* Taking prebiotics or probiotics products in the last month.
* Taking laxatives in the last month.
* Undergoing any medicinal treatment
* Pregnancy
* Subject with a history of current gastrointestinal pathology or disorder such as: acute colon pathology, acute haemorrhagic colitis, suspected digestive perforation, recent abdominal surgery, severe arterial hypertension, abdominal hernia, colon neoplasia, history of cardiac syncope, renal failure, liver cirrhosis, epilepsy, severe psychiatric illness (psychosis), necrosis due to abdominal irradiation, severe anaemia, severe neurovegetative lability.

Primary outcomes:
measure: intestinal transit
timeFrame: 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: Universidad Complutense de Madrid
Study officials:
affiliation: Universidad Complutense de Madrid
name: Isidro Fernández-López, PhD.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05777668: A Predictive Nomogram for Trismus After Radiotherapy for Head and Neck Cancer
Official title: A Predictive Nomogram for Trismus After Radiotherapy for Head and Neck Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Trismus
Keywords: radiation induced trismus, head and neck radiotherapy
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2023-03-21
Enrollment: 104
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with HNC treated consecutively with definitive or postoperative external beam radiotherapy, either alone or in combination with chemotherapy or cetuximab, between January 2017 and April 2021 at Gemelli Advanced Radiation Therapy (ART) center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Brief summary: Background: The aim of this study is to develop a prediction model for radiation-induced trismus (maximal interincisal distance equal to or less than 35 mm) based on a multivariable analysis of dosimetric and clinical factors.

Detailed description: The maximum inter-incisal opening (MIO) of hean and neck cancer (HNC) patients who undergo radiotherapy (RT) ± concurrent chemotherapy with radical intent, will be prospectively measured prior to RT (baseline) and 6 months post-RT.

The potential risk factors (clinical and dosimetric) will be first screened by univariate analysis and then by multivariate analysis. At the end of this process, the features identified as relevant, will be used to fit a logistic regression model and calculate the probability of observed trismus during the 6-month follow-up after RT

Eligibility criteria: Inclusion Criteria:

* HNC
* treatment definitive or postoperative external beam radiotherapy, either alone or in -combination with chemotherapy or cetuximab at least 6 months follow-up

Exclusion Criteria:

* primary tumor out-side the head and neck region, intracranially, or if it originated from the nasal vestibule
* patient death during RT or within the first 6 months after the start of RT, no outcome data available

Primary outcomes:
measure: Trismus
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Fondazione Policlinico Universitario Agostino Gemelli
name: Mariangela Massaccesi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05411068: Reliability And Validity Of Urdu Version Of Disabilities Of The Arm, Shoulder And Hand Questionnaire
Official title: Reliability And Validity Of Urdu Version Of Disabilities Of The Arm, Shoulder And Hand Questionnaire Among Carpal Tunnel Syndrome Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Keywords: Disabilities Of The Arm, Shoulder And Hand Questionnaire
Urdu Version
Reliability
Validity
Carpal Tunnel Syndrome
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2022-06-08
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Carpal tunnel syndrome population of Pakistan will be included in study.

Brief summary: The goal of study is to convert Disabilities Of The Arm, Shoulder And Hand Questionnaire into Urdu and test its reliability and validity among the Pakistani citizens. Also check its correlation with Boston carpal tunnel syndrome questionnaire and visual analogue scale as well.

Detailed description: A cross-sectional study will be conducted after approval from ethical review committee of Riphah international university of Faisalabad. Total of 90 participants will be included in this study from different community areas, hospitals and rehabilitation centers with carpal tunnel syndrome. 71 of them will be male and 19 will be female. Disabilities of the Arm, Shoulder, and Hand questionnaire will be correlated with Boston carpal tunnel syndrome questionnaire and visual analogue scales. These questionnaires will be filled by participants firstly for baseline, secondly after treatment and third one week later as a follow up. Written informed consents will be taken before filling questionnaires.

Eligibility criteria: Inclusion Criteria:

* Age above 18 years.
* Subjects with phalen's and Tinnel's test positive.

Exclusion Criteria:

Participants who had following conditions:

* Diabetes mellitus, thyroid disease, rheumatoid arthritis, radiculopathy of cervical spine, cognitive impairment.
* Hand surgery within previous 3 months.
* Difficulty in understanding of language.
* Musculoskeletal disorder.

Primary outcomes:
measure: Disabilities Of The Arm, Shoulder And Hand Questionnaire
timeFrame: 1st day
measure: Boston carpal tunnel syndrome questionnaire
timeFrame: 1st day
measure: Visual analogue scale
timeFrame: 1st day
Secondary outcomes:
Other outcomes:
Locations:
city: Faisalabad
country: Pakistan
facility: Ripah International University
state: Punjab
Study officials:
affiliation: Riphah International University
name: Muhammad Kashif
role: STUDY_CHAIR
References:
Clinical trial NCT02062268: The Study of KAP on Drink Driving in Jiangsu Province in China
Official title: Study of KAP and Influential Factors on Drink Driving in Public in Jiangsu Province in China
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Drink Driving
Keywords: KAP
drink driving
public
Jiangsu province
China
Lead sponsor: Jiangsu Province Centers for Disease Control and Prevention
Sponsor class: NETWORK
First posted: 2014-02-13
Enrollment: 3565
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: urban and rural residents in Jiangsu province aged 18-70.

Brief summary: Conduct a KAP survey before and after intervention and describe the current knowledge, attitudes and behaviors on drink driving in public and analyse the influential factors to provide rational strategies to enhance the awareness on drink driving in public.


Eligibility criteria: Inclusion Criteria:

* aged 18-70, resident for more than 6 months.

Exclusion Criteria:

* less than 18 or older than 70, or provisional resident.

Primary outcomes:
measure: self-report drink driving rate in public decreases by 2.5%
timeFrame: one and a half year
Secondary outcomes:
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Jiangsu Provincial Center for Disease Control and Prevention
state: Jiangsu
Study officials:
affiliation: Jiangsu CDPC
name: Xiaoning LI, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT04592068: AI Classifies Multi-Retinal Diseases
Official title: Deep Learning-Based Automated Classification of Multi-Retinal Disease From Fundus Photography
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Deep Learning
Retinal Diseases
Lead sponsor: Beijing Tongren Hospital
Sponsor class: OTHER
Collaborators: name: Beijing Tulip Partner Technology Co., Ltd, China
First posted: 2020-10-19
Enrollment: 10000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: community derived dataset

Brief summary: The objective of this study is to establish deep learning (DL) algorithm to automatically classify multi-diseases from fundus photography and differentiate major vision-threatening conditions and other retinal abnormalities. The effectiveness and accuracy of the established algorithm will be evaluated in community derived dataset.

Detailed description: Retinal diseases seriously threaten vision and quality of life, but they often develop insidiously. To date, deep learning (DL) algorithms have shown high prospects in biomedical science, particularly in the diagnosis of ocular diseases, such as diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, glaucoma, and papilledema. However, there is still a lack of a single algorithm that can classify multi-diseases from fundus photography.

This cross-sectional study will establish a DL algorithm to automatically classify multi-diseases from fundus photography and differentiate major vision-threatening conditions and other retinal abnormalities. We will use the receiver operating characteristic (ROC) curve to examine the ability of recognition and classification of diseases. Taken the results of the expert panel as the gold standard, we will use the evaluation indexes, such as sensitivity, specificity, accuracy, positive predictive value, negative predictive value, etc, to compare the diagnostic capacity between the AI recognition system and human ophthalmologist.

Eligibility criteria: Inclusion Criteria:

* fundus photography around 45° field which covers optic disc and macula
* complete patient identification information;

Exclusion Criteria:

* incomplete patient identification information

Primary outcomes:
measure: Area under curve
timeFrame: 1 week
measure: Sensitivity and specificity
timeFrame: 1 week
measure: Positive and negative predictive value
timeFrame: 1 week
measure: Accuracy
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Wen-Bin Wei
state: Beijing
Study officials:
References:
Clinical trial NCT00634868: Treatment of Wounds Utilizing Light
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Diabetic Ulcer
Keywords: ulcer wound diabetes
Lead sponsor: QRay Ltd.
Sponsor class: INDUSTRY
First posted: 2008-03-13
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The Qray device is emitting broad light energy that is intended for diabetic ulcer healing. The study is double blinded.


Eligibility criteria: Inclusion Criteria:

* Patient has 8 weeks venus leg ulcer.
* The ulcer was not better on prior treatment of various medical clinics.
* The patient has diabetic ulcer grade 1 or 2

Exclusion Criteria:

* Patient has severe infection.
* Patient is taking antibiotic
* Patient has ankle brachial index less than 0.7
* Patient is schedule to undergone revascularization surgery 10 weeks before the study
* Patient has photosensitive disease
* Patient has cancer
* Creatinine level is more than 2 mg%
* Patient is taking immunosuppressive medication.
* Pregnant women
* Dialysis patient
* Anaemic patients(less than 9 gr)
* Patient has Albumin level less than 3 mg%

Primary outcomes:
measure: The wound healing process
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Beer Seva
country: Israel
facility: Soroka Medical Center
Study officials:
References: