Clinical trial NCT05257668: Intradialytic High-Intensity Interval Training in Hemodialysis Patients
Official title: The Effect of Intradialytic High-Intensity Interval Training and Moderate Intensity Training on Dialysis Adequacy and Functional Capacity in Hemodialysis Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: End Stage Renal Disease
Exercise, Compulsive
Keywords: intradialytic exercise
high-intensity interval training
chronic kidney disease
dialysis adequacy
functional capacity
Lead sponsor: Istanbul University - Cerrahpasa
Sponsor class: OTHER
Collaborators: name: Istanbul University - Cerrahpasa
First posted: 2022-02-25
Enrollment: 69
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Chronic Kidney Disease (CKD) is defined as a chronic, progressive degeneration state in the regulation of the fluid-electrolyte balance of the kidney and metabolic-endocrine functions as a result of the glomerular filtration rate (GFR) falling below 60 ml/min/1.73 m², regardless of the etiology of the kidney disease. End Stage Renal Failure (ESRD) is the last stage of CRF and is a life-threatening condition. Although the majority of ESRD patients survive on dialysis, their quality of life and functional capacity decrease due to uremic cardiomyopathy, cardiovascular diseases, anemia, diabetes mellitus, bone diseases, deconditioning, fatigue, weakness, inactivity and accompanying psychological problems.

Rehabilitation program including exercise in CKD patients; The program, which is performed under observation on non-dialysis days, can be applied in three ways: the (intradialytic) rehabilitation program performed during hemodialysis in the dialysis unit, and the home exercise program. Intradialytic exercise (IDE) is defined as exercise training performed during the hemodialysis session to increase the patient's strength and endurance and thus target various physiological and psychosocial parameters. Three types of exercises are generally recommended in the exercise program for dialysis patients. These are aerobic exercise, strengthening exercise, and combined aerobic and resistance exercise program. Aerobic exercise (both on dialysis and on non-dialysis days) is the most common type of exercise used in hemodialysis patients. It is stated that physical exercise improves the exercise capacity, muscle strength, functional capacity and quality of life of patients receiving dialysis treatment, provides blood pressure control, reduces the risk of diabetes development and cardiovascular disease, alleviates depression and anxiety symptoms, increases survival and dialysis efficiency.

When the literature is examined, no study has been found that examines how the application of high-intensity intermittent exercise training, which has very important advantages, in the intradialytic process has an effect. Therefore, the aim of our study is to compare the effects of intradialytic high-intensity intermittent exercise training and moderate-intensity exercise training on dialysis effectiveness, functional capacity and quality of life in hemodialysis patients.


Eligibility criteria: Inclusion Criteria:

* Between the ages of 20-65
* Having Stage 5 (ESRD) CRF according to GFR
* Literate
* Cooperative
* Dialysis treatment for at least three months

Exclusion Criteria:

* History of myocardial ischemia in the last 6 months
* Uncontrollable diabetes mellitus,
* Uncontrollable hypertension
* Heart failure
* Malignant disease
* Mental retardation
* Illiteracy
* Uncooperative
* Neurological or orthopedic disability

Primary outcomes:
measure: Dialysis Adequacy
timeFrame: 8 weeks
measure: 6 Minute Walking Test
timeFrame: 8 weeks
measure: 5X Sit-to-Stand Test
timeFrame: 8 weeks
measure: Kidney Disease Quality of Life-36
timeFrame: 8 weeks
Secondary outcomes:
measure: Beck Depression Scale
timeFrame: 8 weeks
measure: Visual Analogue Scale
timeFrame: 8 weeks
measure: Quadriceps muscle strength
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul University- Cerrahpasa
Study officials:
References: