Clinical trial NCT06005779: A Study on the Outcome and Its Influencing Factors in Patients With Borderline Personality Disorder
Official title: An Ambispective Cohort Study on the Prognosis and Its Influencing Factors of Borderline Personality Disorder
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Borderline Personality Disorder
Lead sponsor: Wuhan Mental Health Centre
Sponsor class: OTHER
First posted: 2023-08-22
Enrollment: 270
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Inpatients at the Wuhan Mental Health Center

Brief summary: Borderline personality disorder (BPD) is a difficult chronic mental illness. This diagnosis is common in Western countries. Our researchers want to study the outcome and its influencing factors of BPD for the first time in China. Patients with BPD who had been hospitalized in Wuhan Mental Health Center were selected as the subjects. The researchers retrospectively collected the most recent hospitalization data of these patients, and then prospectively follow up them for 2 years to see how their condition will change. By analyzing all data, researchers hope to know deeply about the development law of this illness, and to provide evidence for releasing these patients' suffering.

Detailed description: This study is an ambispective cohort study. The information collected in the retrospective part mainly included demographic data, comorbid psychiatric diagnosis, psychotherapeutive and pharmacotherapeutive data, times of hospitalization and patients' contact information. The above data were derived from electronic medical records. After informed consent, prospective follow-up was initiated primarily by telephone interviews and web-based questionnaires, or by in-person assessments at hospital return visits. Enrolled patients will be followed up at 6-month intervals after the first follow-up to assess psychiatric diagnosis, social function, and quality of life. The researchers are senior psychiatrists, all of whom received training on the use of questionnaires and inter-investigator consistency before the follow-up.

Cox Proportional Hazard Model is used to analyze the influencing factors of remission of BPD, and Generalized Estimating Equation Model is used to analyze the influencing factors of the patients' social function and quality of life.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of BPD based on ICD-10 (F60.3)

Exclusion Criteria:

* Comorbidity with severe physical disease
* Comorbidity with neurological diseases such as epilepsy
* Comorbidity with mental retardation

Primary outcomes:
measure: remission rate
timeFrame: After the first follow-up, patients will be followed up every 6 months, and the total follow-up time was 2 years.
Secondary outcomes:
measure: social disability
timeFrame: After the first follow-up, patients will be followed up every 6 months, and the total follow-up time was 2 years.
measure: quality of life
timeFrame: After the first follow-up, patients will be followed up every 6 months, and the total follow-up time was 2 years.
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Wuhan Mental Health Centre
state: Hubei
Study officials:
affiliation: Wuhan Mental Health Centre
name: Fan Yang, Master
role: STUDY_DIRECTOR
References: