Clinical trial NCT04501003: Investigation of U1-A Uterine Anomalies Implantation Markers From the Lateral Walls of the Endometrium
Official title: Investigation of Implantation Markers of Anomalies Classified as U1-A Uterine According to ESHRE/ESGE Classification of Female Genital Tractus Anomalies in Biopsy Specimens Obtained From the Lateral Walls of the Endometrium
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: T-Shaped Uterus
Infertility, Female
Genital Tract Anomalies
Keywords: T-Shaped Uterus
Infertility, Female
Intregrin Beta 3
Genital Tract Anomalies
Lead sponsor: Ufuk University
Sponsor class: OTHER
First posted: 2020-08-06
Enrollment: 35
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Various types and classes of uterine malformations have been identified and the ESHRE / ESGE classification system has recently been published on female genital system anomalies. Postoperative positive pregnancy results were obtained in studies conducted in patients with infertility, recurrent implantation failure, and recurrent pregnancy loss, which were not previously described in T-shaped uterine anomalies. Considering the increase in endometrial gland and vascularity after the surgical procedure performed in these patients, our primary goal in our study is to compare the number of implantation markers (αVβ3 integrin) and subepithelial glands in the specimen biopsies taken from the lateral walls of the endometrium before and after hysteroscopic surgery in patients with class U1a anomalies.


Eligibility criteria: Inclusion Criteria:

1. 18-45 age,
2. Have no systemic disease,
3. ESGE U1-A having uterine anomaly,
4. Primary infertile, recurrent implantation loss, recurrent pregnancy loss history,
5. Not having previous uterine surgery.

Exclusion Criteria:

1. Patients over the age of 45 under the age of 18,
2. Those with systemic disease (Hypertension, Heart Disease, Asthma, Renal Disease, Liver Disease, Epilepsy),
3. Having previous uterine surgery,
4. Those who gave birth.

Primary outcomes:
measure: Comparison of endometrial lateral wall biopsies before and after hysteroscopic metroplasty in patients with T-shaped uterus.
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ufuk University
state: Çankaya
Study officials:
References:
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