Clinical trial NCT06106464: Cardiometabolic Effects of Aerobic Exercise Plus Breaking Sitting
Official title: Acute Cardiometabolic Effects of Moderate-Intensity Aerobic Exercise Plus Interrupting Sitting With Different Frequencies of Low-Intensity Physical Activity-A Randomized Crossover Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sedentary Behaviour
Sedentary Time
Keywords: sedentary break
prolonged sitting
blood lipids
blood pressure
aerobic exercise
walking
Lead sponsor: Kastamonu University
Sponsor class: OTHER
First posted: 2023-10-30
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: The goal of this randomized crossover clinical trial is to investigate the effects of interrupting prolonged sitting with intermittent walks of equal volume but at different frequencies, in addition to moderate-intensity aerobic exercise, on postprandial serum lipid profile in young adults between the ages of 18-30. The main questions it aims to answer are:

* Do interrupting prolonged sitting with intermittent walks of equal volume but at different frequencies sustain positive cardiometabolic effects after moderate-intensity aerobic exercise?
* If "yes", which frequency of breaks is more effective to provide cardiometabolic benefits?

Participants will complete four conditions on separate days: 1) 6.5 hours of prolonged sitting after 30 minutes of moderate intensity aerobic exercise 2) breaking prolonged sitting with 2 minutes of walking every 30 minutes after 30 minutes of moderate intensity exercise 3) breaking prolonged sitting with 4 minutes of walking every 1-h after 30 minutes of moderate intensity exercise 4) breaking prolonged sitting with 8 minutes of walking every 2-h after 30 minutes of moderate intensity aerobic exercise.


Eligibility criteria: Inclusion Criteria:

* Being between the ages of 18-30
* Being able to participate in physical activity
* More than 7 hours of daily sitting time measured subjectively
* Not exercising regularly in the last 3 months

Exclusion Criteria:

* Hypertension
* Coronary heart disease
* Heart failure
* Diabetes mellitus
* Metabolic syndrome
* Obesity
* Hypothyroidism
* Non-alcoholic fatty liver disease
* Chronic inflammatory joint disease
* Chronic renal failure
* Cushing's syndrome
* HIV infection
* Being on antihypertensive medication
* Being on lipid-lowering medication
* Being on antidiabetic medication
* Being on systemic glucocorticoid medication
* LDL-cholesterol≥130 mg.dL-1
* HDL-cholesterol \<40 mg.dL-1 for men; \<50 mg.dL-1 for women
* Prediabetes
* Alcohol addiction
* Smoking
* Pregnancy

Primary outcomes:
measure: Capillary glucose area under the curve
timeFrame: During the four 7.5-hour intervention sessions samples will be collected at the 30th, 60th, 90th, 120th and 210th minutes after breakfast, and at the 30th, 60th, 90th, 120th and 210th minutes after lunch.
measure: Serum Low-Density Lipoprotein cholesterol area under the curve
timeFrame: During the four 7.5-hour intervention sessions, 5 mL blood samples will be drawn at the 60th, 120th and 210th minutes after breakfast and at the 60th, 120th and 210th minutes after lunch
measure: Serum High-Density Lipoprotein cholesterol area under the curve
timeFrame: During the four 7.5-hour intervention sessions, 5 mL blood samples will be drawn at the 60th, 120th and 210th minutes after breakfast and at the 60th, 120th and 210th minutes after lunch
measure: Serum total cholesterol area under the curve
timeFrame: During the four 7.5-hour intervention sessions, 5 mL blood samples will be drawn at the 60th, 120th and 210th minutes after breakfast and at the 60th, 120th and 210th minutes after lunch
measure: Serum triglycerides area under the curve
timeFrame: During the four 7.5-hour intervention sessions, 5 mL blood samples will be drawn at the 60th, 120th and 210th minutes after breakfast and at the 60th, 120th and 210th minutes after lunch
Secondary outcomes:
measure: Systolic blood pressure
timeFrame: During the four 7.5-hour intervention sessions, measurements will be carried out approximately at the 20th minute of each hour (10:20, 11:20, 12:20, 13:20, 14:20, 15:20, 16:20)
measure: Diastolic blood pressure
timeFrame: During the four 7.5-hour intervention sessions, measurements will be carried out approximately at the 20th minute of each hour (10:20, 11:20, 12:20, 13:20, 14:20, 15:20, 16:20)
Other outcomes:
Locations:
city: Kastamonu
country: Turkey
facility: Kastamonu University, Çatalzeytin Vocational School
Study officials:
References: