Clinical trial NCT05583721: Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
Official title: An Evaluation of the Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET (Stress-Rest) Myocardial Perfusion Imaging (MYPERS)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Sickle Cell Disease
Keywords: Sickle Cell Disease patients
Healthy controls
Abnormal diastolic heart function
Coronary Flow Reserve (CFR)
Coronary microvasculature dysfunction
Myocardial perfusion reserve
Positron emission tomography (PET) imaging
PET (stress-rest) myocardial perfusion imaging
Lead sponsor: St. Jude Children's Research Hospital
Sponsor class: OTHER
First posted: 2022-10-18
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 21
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart damage seen in SCD patients. They also want to test people who don't have SCD to see if their hearts react the same way under stress.

Primary Objective

* To estimate the coronary flow reserve (CFR) (also referred to as myocardial perfusion reserve), as measured by PET stress-rest myocardial perfusion imaging, in SCD patients with and without diastolic dysfunction, and healthy controls.

Secondary Objectives

* To investigate the relationship between decreased CFR (quantified with PET stress- rest myocardial perfusion imaging) and presence of abnormal diastolic parameters

Detailed description: This study requires two visits. The first visit includes blood tests, an electrocardiogram (EKG), and an echocardiogram. The second visit includes a positron emission tomography (PET) stress test and a blood test.

Subjects will be considered off-study one week after all post PET imaging study tests have been completed along with the next day and one-week follow-up phone calls are completed.

Eligibility criteria: Inclusion Criteria - Stratum A: Sickle cell patients with diastolic dysfunction

* 18 to 21 years of age
* Black
* Diagnosis of SCD of HbSS and HbSβ0thalassemia genotypes
* Three or more abnormal diastolic parameters (based on guidelines by American Society of echocardiography)

Inclusion Criteria - Stratum B: Sickle cell patients without diastolic dysfunction

* 18 to 21 years of age
* Black
* Diagnosis of SCD of HbSS and HbSβ0thalassemia genotypes
* Two or less abnormal diastolic parameters

Inclusion Criteria - Stratum C: Healthy controls

* 18 to 21 years of age
* Black
* Two or less abnormal diastolic parameters

Exclusion Criteria - Stratum A:

* Recent hospitalization for vaso-occlusive pain crisis or acute chest syndrome in last 4 weeks
* Blood transfusion in the last 3 months
* Individuals with signs, symptoms or EKG findings of acute myocardial ischemia, infarction or unstable angina
* Individuals with history of VT/VF or SVT
* Previous cardiac surgery
* Known congenital heart disease (other than patent ductus arteriosus or Atrial septal defect)
* Stenotic valvular disease or left main coronary artery stenosis
* History of myo/pericarditis
* Left ventricle systolic dysfunction
* Cardiovascular instability/uncontrolled hypertension (h/o hypertensive urgency or emergency)
* History of sinus node dysfunction or high grade AV nodal block
* History of aborted sudden cardiac death or cardiac arrest
* Current seizure disorder on AED
* Pregnant/Breast-feeding
* Any medical or social reason, which, in the opinion of the principal investigators would make the participation of the subject ill-advised.

Exclusion Criteria - Stratum B:

* Diagnosed with three or more abnormal diastolic parameters (based on guidelines by American Society of echocardiography)
* Recent hospitalization for vaso-occlusive pain crisis or acute chest syndrome in last 4 weeks
* Blood transfusion in the last 3 months
* Individuals with signs, symptoms or EKG findings of acute myocardial ischemia, infarction or unstable angina
* Individuals with history of VT/VF or SVT
* Previous cardiac surgery
* Known congenital heart disease (other than patent ductus arteriosus or Atrial septal defect)
* Stenotic valvular disease or left main coronary artery stenosis
* History of myo/pericarditis
* Left ventricle systolic dysfunction
* Cardiovascular instability/uncontrolled hypertension (h/o hypertensive urgency or emergency)
* History of sinus node dysfunction or high-grade AV nodal block
* History of aborted sudden cardiac death or cardiac arrest
* Current seizure disorder on AED
* Pregnant/Breast-feeding
* Any medical or social reason, which, in the opinion of the principal investigators would make the participation of the subject ill-advised.

Exclusion Criteria - Stratum C:

* All genotypes of SCD
* Diagnosed with three or more abnormal diastolic parameters (based on guidelines by American Society of echocardiography)
* Anemia of grade 2 or worse (per CTCAE v5.0) at study visit 1
* Individuals with signs, symptoms or EKG findings of acute myocardial ischemia, infarction or unstable angina
* Individuals with history of VT/VF or SVT
* Previous cardiac surgery
* Known congenital heart disease (other than patent ductus arteriosus or Atrial septal defect)
* Stenotic valvular disease or left main coronary artery stenosis
* History of myo/pericarditis
* Left ventricle systolic dysfunction
* Cardiovascular instability/uncontrolled hypertension (h/o hypertensive urgency or emergency)
* History of sinus node dysfunction or high-grade AV nodal block
* History of aborted sudden cardiac death or cardiac arrest
* Current seizure disorder on AED
* Pregnant/Breast- feeding
* Any medical or social reason, which, in the opinion of the principal investigators would make the participation of the subject ill-advised.

Primary outcomes:
measure: Mean and standard deviation of coronary flow reserve (CFR)
timeFrame: Visit 2, approximately 4 weeks after study entry (procedure takes approximately one hour)
measure: CFR difference among Stratum A, Stratum B, and Stratum C
timeFrame: Visit 2, approximately 4 weeks after study entry (procedure takes approximately one hour)
Secondary outcomes:
measure: Relationship between decreased CFR (quantified with PET stress-rest myocardial perfusion imaging) and presence of abnormal diastolic parameters
timeFrame: Visit 2, approximately 4 weeks after study entry (procedure takes approximately one hour)
Other outcomes:
Locations:
city: Memphis
country: United States
facility: St. Jude Children's Research Hospital
state: Tennessee
Study officials:
affiliation: St. Jude Children's Research Hospital
name: Parul Rai, MD
role: PRINCIPAL_INVESTIGATOR
References: