louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03767179: Research of Serum Procalcitonin, ESR, CRP And Leukocyte Levels in Fertile Missed Abortion Cases
Official title: Research of Serum Procalcitonin, Erythrocyte Sedimentation Rate, C-Reactive Protein And Leukocyte Levels in Fertile Missed Abortion Cases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Abortion, Missed
Keywords: Missed abortion
Procalcitonin
Erythrocyte sedimentation rate (ESR)
C-reactive protein (CRP)
Leukocyte (WBC)
Lead sponsor: Karadeniz Technical University
Sponsor class: OTHER
First posted: 2018-12-06
Enrollment: 60
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 60 pregnant women

Brief summary: Aim: The serum procalcitonin, erythrocyte sedimentation rate, c-reactive protein and leukocyte values will be compared between fertile missed abortion diagnosed pregnants and fertile normal pregnants to determine the presence of subclinical infection in the etiology of missed abortion

Detailed description: The study group will consist of 30 fertile, under 35 years old women having for the first time missed abortus diagnosis in the Obstetrics Department of Obstetrics and Gynecology of Medicine Faculty of Karadeniz Technical University, Medical Faculty of Medicine. As control group, 30 cases with the same trimester, fertile, and under 35 years old who had referred to Obstetrics clinic, who had no systemic disease, will be included in the study. Blood samples will be collected at the time of diagnosis of the patients with missed abortion and in normal pregnancy in the week of 20th gestational week and will send to Biochemistry laboratory to examine procalcitonin, erythrocyte sedimentation rate, c-reactive protein and leukocyte values in their sera. The age, weight, gestational week, gravida (number), parity (number), abortus (number), body mass index, systemic diseases, blood group, smoking information, binary test results, and results of genetic analysis will be collected in both groups. The pathology results of the missed abortion group will also be collected. The results will statistically be compared in the SPSS 13.0 program in both groups.

Eligibility criteria: Inclusion Criteria:

* fertile, less than 20 weeks of geese who have missed abortus for the first time without systemic disease

Exclusion Criteria:

* Failure to meet the missed abortus diagnostic criteria (for the group of fertile missed abortus)
* Smoking
* Rejection to participate in the study.

Primary outcomes:
measure: Serum LC
timeFrame: 01.01.2018- 15.02.2019
measure: CRP
timeFrame: 01.01.2018- 15.02.2019
measure: ESR
timeFrame: 01.01.2018- 15.02.2019
measure: Prokalsitonin
timeFrame: 01.01.2018- 15.02.2019
Secondary outcomes:
Other outcomes:
Locations:
city: Trabzon
country: Turkey
facility: Karadeniz Technical University, Medical Faculty of Medicine.
state: Ortahisar
Study officials:
affiliation: KaradenizTU Medicine Faculty
name: Suleyman Guven, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02472379: Writing About Experiences and Health in Older Adults
Official title: Writing About Experiences and Health in Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Social Psychology
Keywords: Immune System
Behavioral Sciences
Women's Health
Health Psychology
Writing
Lead sponsor: University of California, Los Angeles
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2015-06-15
Enrollment: 78
Sex: FEMALE
Minimum age (years): 60
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: UCLA researchers looking for healthy females (age 60+) to participate in a study investigating how writing about your experiences may be related to your health.

Once a week for 6 weeks, participants will write about their experiences and fill out online questionnaires. Participants will also come to the UCLA campus for blood draws and to fill out questionnaires 3 times: once prior to the 6-week writing period, once immediately after the 6-week period, and once 2-months after the writing period.


Eligibility criteria: Inclusion Criteria:

* Healthy adults 60 years and older

Exclusion Criteria:

* Following a structured telephone interview, participants with the following conditions will not be able to participate:

  1. current smokers
  2. active, uncontrolled medical disorders
  3. chronic infection (e.g., Hepatitis C, HIV)
  4. use of certain medications (e.g., hypnotic and psychotropic medication, steroid use, opioid use)
  5. psychiatric disorders (e.g., current major depression, bipolar disorder)
  6. body mass index (BMI) greater than 35

Other exclusion criteria may apply.

Primary outcomes:
measure: Inflammatory activity
timeFrame: baseline, post 6-week writing period, 2-months post-writing period
measure: Health and well-being (self-report)
timeFrame: baseline, post 6-week writing period, 2-months post-writing period
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: UCLA Clinical & Translational Research Center (CTRC)
state: California
Study officials:
affiliation: University of California, Los Angeles
name: Naomi I. Eisenberger, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: University of California, Los Angeles
name: Mona Moieni, M.A.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06307379: Patient Reported Outcome and Experience Measures for Bronchoscopic Procedures
Official title: Patient Reported Outcome and Experience Measures for Bronchoscopic Procedures
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Bronchial Diseases
Keywords: bronchoscopy
endoscopy
patient reported outcome measures
Lead sponsor: Vitaz
Sponsor class: OTHER
First posted: 2024-03-12
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Out-of-hospital care

Brief summary: 'Patient-reported outcomes' (PROMS) and 'patient-reported experiences' (PREMS) are increasingly important parameters in evaluating and adjusting clinical procedures and strategies in healthcare.

Validated disease-specific PROMS related to bronchoscopic procedures are not available and examples in the medical literature are very scarce.

Detailed description: The potential usefulness of PROM/PREMS is multiple:

1. Quality improvement within the current clinical care structure
2. Monitoring the health status of the population
3. Contribution to decision-making regarding financing of care
4. Increase employee and patient involvement in clinical care pathways
5. Rationalize the deployment of medical personnel and resources
6. Integration of data in electronic patient files and registers

Eligibility criteria: Inclusion Criteria:

* Age above 18 years
* Patient referred for diagnostic flexible bronchoscopy
* Procedure performed in outpatient setting

Exclusion Criteria:

* Patient unable to adequately respond to the contents of the patient questionnaire.
* Procedure performed in hospitalised setting
* Patient with active pregnancy

Primary outcomes:
measure: Procedure-related dyspnea scale (VAS)
timeFrame: 24 hours
measure: Procedure-related pain scale (VAS)
timeFrame: 24 hours
measure: Procedure related cough scale (VAS)
timeFrame: 24 hours
measure: General patient satisfaction
timeFrame: 24 hours
Secondary outcomes:
measure: Procedure-related complications:
timeFrame: 24 hours
measure: Sedation-related complications
timeFrame: 24 hours
measure: Diagnostic yield
timeFrame: 30 days
Other outcomes:
Locations:
city: Sint-Niklaas
country: Belgium
facility: VITAZ
Study officials:
affiliation: MD
name: Jonas Yserbyt, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05571579: Biological Collection of Brain Tumors
Official title: Biological Collection of Brain Tumors - GLIOLI Collection
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Brain Tumor
Keywords: Brain tumor
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2022-10-07
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient with brain tumor

Brief summary: The objective of this study is to build a collection of biological samples from patients with brain tumors.


Eligibility criteria: Inclusion Criteria:

* Patient whose diagnosis of brain tumor has been confirmed.
* Adult patients, from 18 years old and without upper age limit
* Patient affiliated to a social security scheme or equivalent.
* Patient able to consent, having dated and signed an informed consent

Exclusion Criteria:

* Pregnant or breastfeeding women
* Patient under guardianship or curators.
* Persons deprived of their liberty by a judicial or administrative decision

Primary outcomes:
measure: number of biological samples
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Bron
country: France
facility: Hospices Civils de Lyon
state: Rhône
Study officials:
References:
Clinical trial NCT00428779: Neuromuscular and Cognitive Fatigue During a 24 Hour Treadmill Running Exercise
Official title: Neuromuscular and Cognitive Fatigue During a 24h Treadmill Running Exercise.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Running during 24 hours
Voluntary evoked force on the muscles
Electrically evoked force on the muscles
EMG activity
Muscle biopsy
subjects will be recruited among experienced ultra-runners
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2007-01-30
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The main purpose of the present study is to determine the relative contributions of central and peripheral fatigue during an ultra-endurance exercise.

Detailed description: For that purpose, 14 subjects running 24 hours on a treadmill will be compared with a control group being awake during the same period. Subjects who running will have electrically evoked forces on the muscles associated EMG activity, blood samples and muscle biopsy.

Eligibility criteria: Inclusion Criteria:

* The subjects of the experimental group will be recruited among experienced ultra-runners . They all have run at least a 12 hour race or longer.
* The control group will be recruited among experienced ultra-runners . Age of control group will be age experimental group more or less 2 years.

Exclusion Criteria:

* The subjects will not be selected if:

  * they were injured in the 3 months before the experiment
  * they had a tendon or joint pathology that could impair strength measurements.
  * they participate to an other experiment at the same time

Primary outcomes:
measure: -Voluntary and electrically evoked forces on the contracted muscles
timeFrame: 24 hours
Secondary outcomes:
measure: Electrically evoked forces on the relaxed muscles and associated EMG activity
timeFrame: 24 hours
measure: Blood samples before the exercise
timeFrame: every 4 hours
measure: Muscle biopsy (vastus lateralis)
timeFrame: before and after the exercise
Other outcomes:
Locations:
city: Saint-etienne
country: France
facility: Pr André GEYSSANT
Study officials:
affiliation: Service de médecine du sport, CHU SAINT-ETIENNE
name: DENIS Christian, Professor
role: STUDY_CHAIR
References:
citation: Morin JB, Samozino P, Feasson L, Geyssant A, Millet G. Effects of muscular biopsy on the mechanics of running. Eur J Appl Physiol. 2009 Jan;105(2):185-90. doi: 10.1007/s00421-008-0888-2. Epub 2008 Oct 8.
citation: Jamart C, Francaux M, Millet GY, Deldicque L, Frere D, Feasson L. Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running. J Appl Physiol (1985). 2012 May;112(9):1529-37. doi: 10.1152/japplphysiol.00952.2011. Epub 2012 Feb 16.
Clinical trial NCT02100579: Ultrasound-guided Adductor Canal Block for Total Knee Replacement
Official title: Ultrasound-guided Adductor Canal Block for Total Knee Replacement: a Randomized, Double-blind Placebo Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Complications; Arthroplasty
Knee Injuries
Lead sponsor: Northwestern University
Sponsor class: OTHER
First posted: 2014-04-01
Enrollment: 40
Sex: ALL
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Total knee arthroplasty is associated with intense early postoperative pain. Fast track recovery programs including early therapy protocols and early hospital discharge are being implemented at various hospitals. The postoperative analgesic pain regimen should enhance functional recovery in addition to providing efficient analgesia with minimal side effects. Adductor canal blockade is commonly used to provide postoperative analgesia for total knee arthroplasty (TKA) surgery. The investigators hypothesize that an ultrasound guided adductor canal block will lower narcotic consumption and improved overall satisfaction compared to ultrasound guided sham block with normal saline (placebo) for patients undergoing minimally invasive TKA surgery.

Detailed description: The investigators hypothesize that an ultrasound guided adductor canal block will lower narcotic consumption and improved overall satisfaction compared to ultrasound guided sham block with normal saline (placebo) for patients undergoing minimally invasive TKA surgery.

Eligibility criteria: Inclusion Criteria:

* Participants 40 to 75 years old who are presenting for minimally invasive total knee arthroplasty under spinal anesthesia

Exclusion Criteria:

* Patient refusal
* American Society of Anesthesiologists physical status classification of 4 or higher
* Pre-existing neuropathy in the femoral or sciatic distribution
* Coagulopathy
* Infection at the site
* Chronic opioid use (greater than 3 months)
* Pregnancy
* Medical conditions limiting physical therapy participation
* Any other contra-indication to regional anesthesia

Primary outcomes:
measure: Opioid Consumption (mg morEq)
timeFrame: 36 hours
Secondary outcomes:
measure: Visual Analog Scale Pain Score
timeFrame: Pain burden at 36hr
measure: Length of Hospitalization
timeFrame: 0 to 192 hours
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine
state: Illinois
Study officials:
affiliation: Northwestern University Feinberg School of Medicine
name: Antoun Nader, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04057079: Comparing Anugel With Gelatine Sponges for Pain Management After Hemoroidectomy
Official title: Anugel vs Gelatine Sponge Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Pain, Postoperative
Keywords: Hemoroidectomy
Lead sponsor: Deep Life Medical Ltd
Sponsor class: INDUSTRY
First posted: 2019-08-15
Enrollment: 110
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Research staff used a computer-based tool to allocate the ligasure haemorrhoidectomy patients randomly to either Group 1 (n=56) who received standard anal gelatine sponge (SpongostanTM) or Group 2 (n-54) to a layered hydrogel sponge (AnugelTM) following surgery. Encryption concealed the allocation until the patient's details had been logged.
Primary purpose: SUPPORTIVE_CARE

Brief summary: Post-operational pain is the most common problem relating to haemorrhoidectomy. This study aims to evaluate the postoperative effects of Anugel a hydrogel impregnated multi component sponge vs gelatine sponge comparatively.

Detailed description: The patients were placed in the lithotomy position. Haemorrhoids (piles) were later located through exploration. The piles were dissected using ligasure. After completing the dissection, bleeding was controlled and either Anugel or the gelatine sponge (SpongostanTM) is inserted in to the rectum as determined by patient allocation.

The patients were monitored post operation and 5 days following the surgery. Pain was measured using the VAS scale and use of pain medication was monitored.

Eligibility criteria: Inclusion Criteria:

* Haemorrhoid (grade 3-4)

Exclusion Criteria:

* Repeating cases, additional (non haemorrhoid related) complications

Primary outcomes:
measure: Pain Reduction
timeFrame: 5 days
Secondary outcomes:
measure: Use of analgesics
timeFrame: 5 days
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Memorial Sisli Hospital
state: Sisli
Study officials:
References:
Clinical trial NCT03717779: Contribution LUS in the Diagnosis of Acute Heart Failure (AHF) in Patients Admitted to the ED
Official title: Contribution of Pulmonary Ultrasonography in the Diagnosis of Acute Heart Failure (AHF) in Patients Admitted to Emergency Department (ED) for Dyspnea
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dyspnea; Cardiac
Keywords: Lung ultrasound,
heart failure
diagnosis
accuracy
Lead sponsor: University of Monastir
Sponsor class: OTHER
First posted: 2018-10-24
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: all patients admitted to the ED with acute dyspnea, with the final diagnosis of heart failure by the ICU team

Brief summary: This study assesses the potential of lung ultrasonography to diagnose heart failure.

Detailed description: Dyspnea is one of the most distressing situations for the patient . Emergency cases do not always present in conditions that are ideal for immediate diagnosis, which sometimes compromises outcome. Physical examination, laboratory findings and radiography are imperfect, resulting in a need for sophisticated test results that delay management.

Lung ultrasonography is becoming a standard tool in critical cases in the ED.

the investigators aim to perform ultrasonography on consecutive patients admitted to the ICU with dyspnea, comparing lung ultrasonography results on initial presentation with the final diagnosis by the ICU team.

Three items were assessed: artifacts (horizontal A lines or vertical B lines indicating interstitial syndrome), lung sliding, and alveolar consolidation and/or pleural effusion, these items were grouped to assess ultrasound profiles.

This study assesses the potential of lung ultrasonography to diagnose heart failure.

Eligibility criteria: Inclusion Criteria:

* non traumatic dyspnea with the final diagnosis of heart failure

Exclusion Criteria:

* coma,
* shock,Mechanical Ventilation,
* vasopressor drugs
* arrhythmia serious and sustained,
* non consent

Primary outcomes:
measure: the accuracy of LUS in the diagnosis of heart failure
timeFrame: 0 days
Secondary outcomes:
Other outcomes:
Locations:
city: Monastir
country: Tunisia
facility: Emergency department of university hospital Fattouma Bourguiba of Monastir
Study officials:
affiliation: University hospital of Monastir
name: Nouira Semir, PHD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Msolli MA, Sekma A, Marzouk MB, Chaabane W, Bel Haj Ali K, Boukadida L, Bzeouich N, Gannoun I, Trabelssi I, Laaouiti K, Grissa MH, Beltaief K, Dridi Z, Belguith A, Methamem M, Bouida W, Boukef R, Boubaker H, Nouira S; GREAT Network. Bedside lung ultrasonography by emergency department residents as an aid for identifying heart failure in patients with acute dyspnea after a 2-h training course. Ultrasound J. 2021 Feb 9;13(1):5. doi: 10.1186/s13089-021-00207-9.
Clinical trial NCT04192279: Early Lactate Clearance Rate in Sepsis
Official title: Monitoring and Guidance of Early Lactate Clearance Rate in Patients With Sepsis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Early Lactate Clearance
Keywords: sepsis
lactate
early
Lead sponsor: The Second Hospital of Hebei Medical University
Sponsor class: OTHER
First posted: 2019-12-10
Enrollment: 220
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with severe sepsis or septic shock were recruited from Emergency ICU of the second hospital of Hebei Medical University.

Brief summary: To assess the Influence of early lactate clearance rate monitoring in patients with sepsis.


Eligibility criteria: Inclusion Criteria:

* All patients whose blood lactate level reached or exceeded 2.0 mEq / L

Exclusion Criteria:

* Incomplete clinical data

Primary outcomes:
measure: In-hospital 60days mortality
timeFrame: In-hospital 60 days
measure: ICU mortality
timeFrame: up to 30 days
Secondary outcomes:
Other outcomes:
Locations:
city: Shijiazhuang
country: China
facility: The Second Hospital of Hebei Medical University
state: Hebei
Study officials:
References:
Clinical trial NCT03154879: Frontal Amplitude-integrated Electroencephalogram in Early Prognostication After Cardiac Arrest
Official title: Prospective Multi-center Study to Verify Neurological Prognostic Value of Amplitude-integrated Electroencephalogram in Cardiac Arrest Patients Treated With Therapeutic Hypothermia
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Heart Arrest
Keywords: Heart arrest
Hypothermia
EEG
Prognosis
Lead sponsor: Seoul St. Mary's Hospital
Sponsor class: OTHER
First posted: 2017-05-16
Enrollment: 500
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Comatose cardiac arrest survivors treated with TH

Brief summary: The investigators examine the prognostic value of continuous electroencephalography on frontal area of brain according to time by performing amplitude-integrated electroencephalography (aEEG) on cardiac arrest patients receiving therapeutic hypothermia.


Eligibility criteria: Inclusion Criteria:

* age: 19 years and older
* underwent TH

Exclusion Criteria:

* Died within 72 h after cardiac arrest
* Spontaneous or traumatic brain injury
* Known history of neurological diseases (such as epilepsy)

Primary outcomes:
measure: Comparison of time to normal trace to good neurological outcome evaluated by cerebral performance category (CPC) score 1 to 2
timeFrame: at day 180
Secondary outcomes:
measure: Comparison of time to normal trace to poor neurological outcome evaluated by CPC score 3 to 5
timeFrame: at day 180
measure: Comparison of unfavorable aEEG patterns to poor neurological outcome evaluated by CPC score 3 to 5
timeFrame: at day 180
measure: Comparison of diffusion weighted image (DWI) to poor neurological outcome evaluated by CPC score 3 to 5
timeFrame: at day 180
measure: Comparison of the levels of serum neuron specific enolase (NSE) to poor neurological outcome evaluated by CPC score 3 to 5
timeFrame: at day 180
measure: Comparison of convulsive movement and electrical status epilepticus (SE) to poor neurological outcome evaluated by CPC score 3 to 5
timeFrame: at day 180
Other outcomes:
Locations:
city: Changwon
country: Korea, Republic of
facility: Samsung Changwon Hospital
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University
city: Seoul
country: Korea, Republic of
facility: Seoul St. Mary's hospital
city: Seoul
country: Korea, Republic of
facility: KEPCO Medical Center
Study officials:
affiliation: Seoul St. Mary's Hospital
name: Kyu Nam Park, MD
role: STUDY_CHAIR
References: