Clinical trial NCT03037255: Association of Long-term Conditions With Survival Following Heart Attack in England and Wales
Official title: Association of Long-term Conditions With Survival Following Acute Myocardial Infarction in England and Wales
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Myocardial Infarction
Diabetes Mellitus
Peripheral Vascular Disease
Chronic Heart Failure
Cerebrovascular Disease
Chronic Renal Failure
Chronic Obstructive Pulmonary Disease
Lead sponsor: University of Leeds
Sponsor class: OTHER
First posted: 2017-01-31
Enrollment: 693633
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with ST-segment elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI) admitted to one of 247 hospitals in England and Wales between 1st January 2003 and 30th June 2013

Brief summary: This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack register.

Detailed description: Using observational data from the Myocardial Ischaemia National Audit Project (MINAP) of all hospitalisations for acute myocardial infarction in all acute hospitals in England and Wales, this study aims to determine the extent to which pre-existing long-term conditions are associated with survival following acute myocardial infarction. The study will include an investigation of individual long term conditions for patients with acute myocardial infarction, including chronic heart failure, cerebrovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, chronic renal failure or peripheral vascular disease as well as the combination of such conditions and their resulting impact on long term all-cause mortality (up to 8.4 years). In addition, an investigation of the association of receipt of guideline recommended care for acute myocardial infarction patients with pre-existing long term conditions will be made.

Eligibility criteria: Inclusion Criteria:

* Patients must be 18 years or older

Exclusion Criteria:

* Patients for which mortality data are missing

Primary outcomes:
measure: Number of patients who died from any cause by the end of the study censoring period
timeFrame: 8.4 years
Secondary outcomes:
measure: Number of patients who received guideline recommended therapy during the study period
timeFrame: Any guideline therapy administered during the patients hospital admission for acute myocardial infarction, an average of 4 days
Other outcomes:
Locations:
Study officials:
affiliation: University of Leeds
name: Chris Gale, PhD, FRCP
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hall M, Dondo TB, Yan AT, Mamas MA, Timmis AD, Deanfield JE, Jernberg T, Hemingway H, Fox KAA, Gale CP. Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort. PLoS Med. 2018 Mar 6;15(3):e1002501. doi: 10.1371/journal.pmed.1002501. eCollection 2018 Mar.