louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05528003: Homemade Versus Commercialized Single-access Port Devices in Single-incision Laparoscopic Appendectomy
Official title: Comparison of Homemade Versus Commercialized Single-access Port Devices for Single-incision Laparoscopic Appendectomy: A Retrospective Comparative Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Minimally Invasive Surgical Procedures
Keywords: Single-incision laparoscopic appendectomy
Single-access port device
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2022-09-06
Enrollment: 161
Sex: ALL
Minimum age (years): 9
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Acute appendicitis patients

Brief summary: Homemade and commercialized single-assess port devices are two kinds of port devices commonly used for single-incision laparoscopic appendectomy. This study aimed to compare these two port devices in terms of short-term surgical outcomes and medical costs.

Detailed description: The advantages of homemade port devices include accessibility of the composites and lower equipment costs to the patients; however, the potential disadvantage is the easy leakage of CO2, ballooning of the surgical glove, and device instability, leading to difficult maneuverability. On the other hand, commercialized port devices have relatively easy maneuverability, flexibility for instrument changes, and port stability for long-duration surgery ; however, their higher equipment cost is a disadvantage.

Eligibility criteria: Inclusion Criteria:

* The patients were diagnosed as acute appendicitis and undergoing single-incision laparoscopic appendectomy

Exclusion Criteria:

* The patient was not diagnosed as acute appendicitis based on surgical finding or pathological findings
* The patients underwent surgery other than single-incision laparoscopic surgery

Primary outcomes:
measure: Total surgical complications
timeFrame: Complications happened within 30 days
measure: Superficial incisional surgical site infection (SSI)
timeFrame: Complications happened within 30 days
measure: Deep/organ SSI
timeFrame: Complications happened within 30 days
measure: Postoperative ileus
timeFrame: Complications happened within 30 days
Secondary outcomes:
measure: Surgical time
timeFrame: Time from skin incision to application of gauzes
measure: Time to resume soft diet
timeFrame: The time to resume a soft diet was measured as the duration between the time leaving the recovery room and the time to resume a soft diet recorded in the nursing note.
measure: Postoperative length of hospitalization
timeFrame: Postoperative LOH was defined as the duration between leaving the recovery room and discharge.
measure: Total medical costs
timeFrame: From the time patient being brought to emergency room to the time patient being discharged
Other outcomes:
Locations:
Study officials:
affiliation: NTUH, Hsin-Chu Hospital
name: Yu-Tso LIAO, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02862743: Molecular Characterization of Advanced Stage Melanoma by Blood Sampling
Official title: Molecular Characterization of Advanced Stage Melanoma by Blood Sampling
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Metastatic Melanoma
Lead sponsor: CHU de Reims
Sponsor class: OTHER
First posted: 2016-08-11
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Analysis of somatic mutations in tumors is currently indicated for daily practice in all metastatic melanoma. Actually, this research is limited to the mutation of three biomarkers validated by the l'Institut National du CAncer (INCA): BRAF, NRAS and CKIT. Moreover, in some cases it requires invasive biopsies.

In this context, molecular characterization of a tumor material flowing (circulating tumor DNA and / or circulating tumor cells) could afford to benefit patients in the best conditions of current targeted therapies and future.

Detailed description: The main objective of this study will be to define the diagnostic sensitivity of a panel of biomarker on the circulating tumor DNA from peripheral blood.

The secondary objectives of this study will be:

* Study the concordance between mutations in circulating tumor DNA and mutations in tumor tissue - Study the associations between mutational profiles and clinical and histological features of melanoma.
* Study the prognostic impact on survival of the identified genetic profile from the circulating tumor DNA

Eligibility criteria: Inclusion Criteria:

* patient with melanoma confirmed histologically
* patient with metastatic melanoma (stage III unresectable or stage IV)
* patient consenting to participate to the study
* patient enrolled in the national healthcare insurance program
* patient older than 18 years

Exclusion Criteria:

- Metastatic tumor whose origin is doubtful (uncertain melanoma)

Primary outcomes:
measure: Diagnostic sensitivity of a panel of biomarker on the circulating tumor DNA from peripheral blood
timeFrame: Day 0
Secondary outcomes:
Other outcomes:
Locations:
city: Reims
country: France
facility: Chu de Reims
Study officials:
References:
Clinical trial NCT03923543: Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Congenital Heart Disease
Official title: Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Congenital Heart Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sepsis Newborn
Lead sponsor: Tepecik Training and Research Hospital
Sponsor class: OTHER
First posted: 2019-04-22
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study was conducted in the NICU of Tepecik Training and Research Hospital, İzmir,

Brief summary: The use of neutrophil lymphocyte ratio is useful for the detection of infection status in newborns after surgery

Detailed description: The use of neutrophil lymphocyte ratio is useful for the detection of infection status in newborns after surgery and we compare this with other acute phase reactants

Eligibility criteria: Inclusion Criteria:

* newborn to be operated with the diagnosis of congenital heart disease

Exclusion Criteria:

* age older than 1 month not to be operated

Primary outcomes:
measure: Neutrophil to Lymphocyte Ratio
timeFrame: 1 day
measure: Neutrophil to Lymphocyte Ratio
timeFrame: 2 week
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02966743: Effect of Sedatives on Regional Cerebral Oxygen Saturation
Official title: Effect of Medazolam or Dexmedetomidine on Regional Cerebral Oxygen Saturation During Spinal Anesthesia in the Elderly Patients
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Cerebral Ischemia-Hypoxia
Lead sponsor: Gachon University Gil Medical Center
Sponsor class: OTHER
First posted: 2016-11-17
Enrollment: 0
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Compare the changes of regional cerebral oxygen saturation during midazolam or dexmedetomidine sedation for spinal anesthesia in the elderly patients who undergoing femur surgery.

Detailed description: Compare the changes of regional cerebral oxygen saturation during midazolam or dexmedetomidine administration (target bispectrl index 75-80) for spinal anesthesia in the elderly patients over 65 years who undergoing femur surgery.

Eligibility criteria: Inclusion Criteria:

* patinets who undergoing femur surgery under spinal anesthesia

Exclusion Criteria:

* previous cerebrovascular disease, uncontrolled cardiovascular disorder, uncontrolled pulmonary disease

Primary outcomes:
measure: regional cerebral oxygen saturation
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Hospital
Study officials:
affiliation: Gachon University Gil Medical Center
name: Youn Yi Jo, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06357390: Physiologic and Clinical Effect of High-flow Oxygen Therapy in Tracheostomized Patients With Prolonged Mechanical Ventilation Undergoing Weaning Trials
Official title: Physiologic and Clinical Effect of High-flow Oxygen Therapy in Tracheostomized Patients With Prolonged Mechanical Ventilation Undergoing Weaning Trials
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: High Flow Oxygen Therapy
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2024-04-10
Enrollment: 10
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who were transferred to RCC and tried to get out of the ventilator after tracheotomy

Brief summary: This study is aimed at patients who have been admitted to the respiratory care center of this hospital who meet the PMV conditions (defined as continuous use of the ventilator for at least ten days) who are about to receive the ventilator out of training. After obtaining the explanatory consent, they will undergo continuous complete Before and after spontaneous breathing training, collect various relevant physiological data of lung volume and ventilation perfusion distribution, and analyze and predict the correlation of ventilator detachment.


Eligibility criteria: Inclusion Criteria:

* Be at least 20 years old, have undergone tracheotomy, have been using a ventilator for at least 10 days, and have stable vital signs.

Exclusion Criteria:

* Age \<20 years
* The oxygen concentration (FiO2) provided by the respirator exceeds 60%
* pregnant
* Blood pressure-systolic blood pressure below 70 mmHg
* Heartbeat is lower than 50/min or higher than 160/min
* Respiration rate is higher than 50/min
* Lack of voluntary breathing

Primary outcomes:
measure: ventilation perfusion distribution measurement
timeFrame: 16 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: Jih-Shuin Jerng, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06367790: Plyometry and Tapping in the Functional Improvement of Non-professional Basketball Players
Official title: Plyometry and Tapping in the Functional Improvement of Non-professional Basketball Players. Randomised Clinical Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Basketball Players
Keywords: Basketball
Plyometric exercises
Dry needling
Range of motion
Vertical jump.
Lead sponsor: Universidad Católica San Antonio de Murcia
Sponsor class: OTHER
First posted: 2024-04-16
Enrollment: 19
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Introduction. In basketball, the lower extremities have the highest prevalence of injury, regardless of gender and professional category.

Objective. To analyse the efficacy of a physiotherapy intervention using a protocol of plyometric exercises and dry needling in non-professional basketball athletes.

Methods. Randomised clinical study. 20 players will be randomised to an experimental group (plyometric exercises and dry needling of the gastrocnemius muscles) and a control group (plyometric exercises). The intervention will include 8 sessions over 4 weeks. The study variables will be: range of motion in dorsal flexion in loading (Leg Motion®) and unloading (goniometer) and vertical jump (MyJump2®).

Expected results. An intervention of plyometric exercises and dry needling produces significant differences in range of motion and vertical jump in basketball players, compared to the isolated administration of plyometric exercises.


Eligibility criteria: Inclusion Criteria:

* Non-professional basketball players who are in competition.
* Subjects over 18 years of age
* Athletes competing in the first men's division of the basketball federation of the Region of Murcia.
* Sign the informed consent document.

Exclusion Criteria:

* Subjects who are injured at the time of data collection.
* Subjects who are unable to attend all training sessions during the duration of the research.
* Athletes with apprehension to dry needling.

Primary outcomes:
measure: Change from baseline range of motion in loaded dorsal flexion after treatment and at 4 weeks
timeFrame: Screening visit, within the first seven days after treatment and after four weeks follow-up visit
Secondary outcomes:
measure: Change from baseline range of motion in unloaded dorsal flexion after treatment and at 4 weeks
timeFrame: Screening visit, within the first seven days after treatment and after four weeks follow-up visit
measure: Change from baseline vertical jump after treatment and at 4 weeks
timeFrame: Screening visit, within the first seven days after treatment and after four weeks follow-up visit
Other outcomes:
Locations:
city: Oviedo
country: Spain
facility: Rubén Cuesta-Barriuso
state: Asturias
Study officials:
References:
Clinical trial NCT01496690: Pregablin for Anxiety-comorbidity in Patients With Schizophrenia
Official title: Pregablin for Anxiety-comorbidity in Patients With Schizophrenia - a Double-blinded Randomized Placebo Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Schizophrenia
Anxiety-comorbidity to Schizophrenia
Keywords: Anxiety-comorbidity to schizophrenia
Double-blinded randomized placebo controlled trial
Pregabalin
Lead sponsor: University of Aarhus
Sponsor class: OTHER
Collaborators: name: Albert Einstein College of Medicine
name: GCP-unit at Aarhus University Hospital, Aarhus, Denmark
name: The Hospital Pharmcacy North Denmark Region, Denmark
name: Pfizer
First posted: 2011-12-21
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The PACS study aims to investigate the efficacy and tolerability of pregabalin for schizophrenic patients that suffer from comorbid anxiety.

The study design is an 8 week flexible dosage, randomized placebo controlled.

The study population is patients diagnosed with ICD-10 schizophrenia and age 18-65. Patients are recruited from outpatient clinics from entire Denmark.


Eligibility criteria: Inclusion Criteria:

* Ages 18-65 years
* An ICD-10 schizophrenia diagnosis F20.0-20.3 or F20.9
* Stable dosage of psychotropic 4 weeks before inclusion
* Hamilton Anxiety Scale total score \> 15
* Positive and Negative Syndrome Scale for Schizophrenia total score \< 70
* The Calgary Depression Scale for Schizophrenia total score \< 10
* Fertile women: Contraception during the trial
* S-creatinin within normal reference range
* Signed informed consent and power of attorney

Exclusion Criteria:

* Significant substance abuse
* QTc \> 480 milliseconds
* Severe dysregulated diabetes
* For women: Pregnancy or breast-feeding
* Confinement in accordance with the Danish Law of Psychiatry
* Concrete suicidally
* Known hypersensitivity or allergic reaction to the active ingredient of the drug

Primary outcomes:
measure: Hamilton Anxiety Scale
timeFrame: Baseline - 4 weeks treatment - 8 weeks treatment
Secondary outcomes:
measure: UKU-Overall adverse effect scale
timeFrame: Baseline - 4 weeks treatment - 8 weeks treatment
Other outcomes:
Locations:
city: Aalborg
country: Denmark
facility: Aalborg University Hospital, Psychiatry
Study officials:
affiliation: Aalborg University Hospital
name: Ole Schjerning, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06879990: Retrograde Saline Irrigation During Supine Mini Percutaneous Nephrolithotomy
Official title: The Role of Retrograde Saline Irrigation Through Double Lumen Ureteric Catheter During Supine Mini-percutanous Nephrolithotomy for Renal Stones Extraction:a Prospective Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Renal Stone
Supine Mini Percutaneous Nephrolithotomy
Keywords: Supine
Lead sponsor: Kafrelsheikh University
Sponsor class: OTHER
First posted: 2025-03-17
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This minimally invasive surgery allows us to remove kidney stones through tiny incisions and provides patients with quicker and smoother recoveries


Eligibility criteria: Inclusion Criteria:

* age above 18 years
* renal stones

Exclusion Criteria:

* age less than 18 years

Primary outcomes:
measure: Stone free rate
timeFrame: two weeks from primary procedure
Secondary outcomes:
measure: Assess operative time
timeFrame: During procedure
measure: Post operative complication
timeFrame: Up to 48 hours
Other outcomes:
Locations:
city: Kafr Ash Shaykh
country: Egypt
facility: Elsayed Abdelhalim
state: State
Study officials:
References:
Clinical trial NCT06206590: Analysis of Differential Proteins and Maternal Influencing Factors of Septic Shock in Neonates
Official title: Analysis of Differential Proteins and Maternal Influencing Factors of Septic Shock in Neonates Born to ≤32-week Preterm Infants or Infected Mothers During Pregnancy
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Neonatal Disease
Lead sponsor: Guangdong Women and Children Hospital
Sponsor class: OTHER
First posted: 2024-01-16
Enrollment: 116
Sex: ALL
Minimum age (years): 1
Maximum age (years): 1
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Newborns who born in Guangdong Women and Children Hospital

Brief summary: 1. Explore 32 weeks of premature infants or maternal pregnancy infection of newborn septic shock maternal influence factors. 2. Through maternal blood samples before delivery and labor cord blood sample screening and septic shock related proteomics analysis, explore the relationship between the difference protein and septic shock and prognosis, and explore the pathway mechanism, in order to prevent and reduce the occurrence of septic shock in premature infants

Detailed description: The birth cohort was established with 32 weeks of premature infants or maternal infection during pregnancy.Whole proteomic analysis was performed on maternal blood before delivery and umbilical cord blood samples at delivery,and screscreen differential proteins associated with septic shock and classify these proteins as leak factor into exposed and non-exposed groups for cohort study.The incidence and mortality of shock,severe brain injury and BPD in the two groups were compared, and the mechanism of the differential protein was studied to provide early warning in children with septic shock.

Eligibility criteria: Inclusion Criteria:

* All ≤32-week premature infants admitted to our NICU; All newborns delivered by the mother infected during pregnancy

Exclusion Criteria:

* Not delivered in our hospital; congenital cardiovascular development malformation, fetal malformation, genetic metabolic diseases, etc

Primary outcomes:
measure: The incidence and mortality of shock
timeFrame: 1/10/2025
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Guangdong Women and Children Hospital
state: Guangdong
Study officials:
affiliation: Guangdong Women and Children Hospital
name: xiuzhen ye
role: STUDY_CHAIR
References:
Clinical trial NCT04381390: Egg Consumption and Muscular Adaptations
Official title: Comparison of Whole Eggs vs. Egg Whites Consumption on Regulatory Myokines, Muscular Strength, Hypertrophy, Power and Body Composition.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertrophy
Lead sponsor: Marymount University
Sponsor class: OTHER
Collaborators: name: Tehran University
First posted: 2020-05-08
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Eggs may be a viable alternative to various types of supplemental proteins given its similar ratings on various measures of dietary protein quality.

The investigators hypothesis is that whole eggs would create a greater improvement in skeletal regulatory markers, hormonal responses and body composition than egg white ingestion in resistance-trained men.

Detailed description: The aim of this investigation was to compare the effects of whole egg versus egg white ingestion (daily and after training sessions) during 12 weeks of resistance training on skeletal muscle regulatory markers, hormonal responses and body composition in resistance-trained men. Specific aims of the study are to:

To investigate the extent to which both whole egg and egg white ingestion will improve anabolic factors, fat free mass, fat mass and decrease catabolic markers after 12 weeks of resistance training in resistance-trained men.

Eligibility criteria: Inclusion Criteria:

* performing resistance training at least three times a week for 1 year prior to the start of the study
* not taking any dietary supplements or medications for at least 1 year prior to the start of the study
* no known medical issues
* no alcohol consumption or smoking for at least 1 year prior to the start of the study
* no egg allergy/sensitivity.

Exclusion Criteria:

* non-willingness to continue nutritional or exercise protocols
* participation in exercise other than the prescribed resistance training program
* consumption of dietary supplement (other than egg) during the study period
* Missing more than one resistance training session or post-exercise egg consumption throughout the study period

Primary outcomes:
measure: Circulatory Myokines levels
timeFrame: 12 weeks
measure: Circulatory hormone levels
timeFrame: 12 weeks
measure: Muscle mass
timeFrame: 12 weeks
measure: Body fatness
timeFrame: 12 weeks
Secondary outcomes:
measure: Muscular Strength
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Arlington
country: United States
facility: Marymount University
state: Virginia
Study officials:
affiliation: Marymount University
name: Alexei Wong
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bagheri R, Hooshmand Moghadam B, Ashtary-Larky D, Forbes SC, Candow DG, Galpin AJ, Eskandari M, Kreider RB, Wong A. Whole Egg Vs. Egg White Ingestion During 12 weeks of Resistance Training in Trained Young Males: A Randomized Controlled Trial. J Strength Cond Res. 2021 Feb 1;35(2):411-419. doi: 10.1519/JSC.0000000000003922.