Clinical trial NCT00349869: Yoga for Rheumatoid Arthritis
Official title: Yoga for Persons With Rheumatoid Arthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Rheumatoid Arthritis
Osteoarthritis
Keywords: inflammatory arthritis
rheumatoid arthritis
knee osteoarthritis
arthritis
yoga
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
Collaborators: name: National Center for Complementary and Integrative Health (NCCIH)
First posted: 2006-07-10
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled trial
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the impact of yoga on inflammatory arthritis and knee osteoarthritis.

Detailed description: Yoga is a set of ancient Indian theories and practices, focusing on unifying mind, body, and spirit, and promoting strength, balance, and flexibility. The physical aspect of yoga includes poses, breathing techniques, and relaxation. Inflammatory arthritis, a chronic disease characterized by inflammation of the lining of the joints, can cause long-term joint damage, resulting in chronic pain, loss of function, and disability.

The primary objective of this study is to learn how people with inflammatory arthritis and knee osteoarthritis respond to an exercise program of yoga. To accomplish this, 30 persons with inflammatory arthritis or knee osteoarthritis will be randomly assigned to one of two groups. Group one will begin an immediate 8-week program of yoga classes consisting of 60-minute sessions, twice a week. Group two, or the "waitlist" control group, will receive 8 weeks of arthritis education followed by the same 8-week yoga program as group one. Participants also will have blood drawn, and complete various tests. The yoga classes will be taught by an experienced, certified yoga instructor, and are designed especially for the needs of people with inflammatory arthritis and knee osteoarthritis.

This study will provide important data on integrating mind-body activities into the treatment of inflammatory arthritis and knee osteoarthritis.

Eligibility criteria: Inclusion Criteria:

* Age 18+ (RA only upper age limit 70)
* Confirmed or probable OA (using pre-specified criteria) OR Rheumatoid arthritis (participation approved by rheumatologist)
* Currently sedentary (physically active for 20 min \< 3times/week)

Exclusion Criteria:

* Inability to ambulate without use of assistive device
* Uncontrolled high blood pressure or existing heart condition
* Co-morbid inflammatory condition with overlapping symptoms (i.e., fibromyalgia)
* Surgery within 6 months

Primary outcomes:
measure: Physical Health
timeFrame: baseline, post intervention, follow-up
Secondary outcomes:
measure: Mobility/Fitness
timeFrame: baseline, posttest, follow-up
measure: RA Disease Activity
timeFrame: baseline, post intervention, follow-up
measure: Psychological Function
timeFrame: baseline, , posttest, follow-up
measure: HRQL
timeFrame: baseline, post intervention, follow-up
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Johns Hopkins Arthritis Center, 5501 Hopkins-Bayview Circle, Ste 1B.14
state: Maryland
Study officials:
affiliation: Associate Professor of Medicine, Johns Hopkins Rheumatology
name: Susan J. Bartlett, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bartlett SJ, Moonaz SH, Mill C, Bernatsky S, Bingham CO 3rd. Yoga in rheumatic diseases. Curr Rheumatol Rep. 2013 Dec;15(12):387. doi: 10.1007/s11926-013-0387-2.
citation: Haaz S, Bartlett SJ. Yoga for arthritis: a scoping review. Rheum Dis Clin North Am. 2011 Feb;37(1):33-46. doi: 10.1016/j.rdc.2010.11.001. Epub 2010 Dec 3.
citation: Haaz S, Bingham CO, Bathon JM, Bartlett SJ. The effect of yoga on clinical parameters in patients with rheumatoid arthritis. Arthritis & Rheumatism 2008;58:S893-S4.
citation: Haaz S, Bingham III CO, Bartlett SJ. Adherence to an 8-week yoga program for RA and OA: Who drops out and why? Arthritis & Rheumatism 2009;60:1978.
citation: Moonaz SH, Bingham CO 3rd, Wissow L, Bartlett SJ. Yoga in Sedentary Adults with Arthritis: Effects of a Randomized Controlled Pragmatic Trial. J Rheumatol. 2015 Jul;42(7):1194-202. doi: 10.3899/jrheum.141129. Epub 2015 Apr 1.