Clinical trial NCT05839743: Investigation of the Effects of Aerobic Exercise, Balance Exercise and Combined Exercise Practices on Frailty, Balance, Fall Risk, Reaction Time, Cognitive Functions and Quality of Life in Dementia Patients
Official title: Investigation of the Effects of Aerobic Exercise, Balance Exercise and Combined Exercise Practices on Frailty, Balance, Fall Risk, Reaction Time, Cognitive Functions and Quality of Life in Dementia Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dementia
Aerobic Exercise
Balance Exercise
Cognitive Function
Frailty
Reaction Time
Lead sponsor: Yuksek Ihtisas University
Sponsor class: OTHER
First posted: 2023-05-03
Enrollment: 33
Sex: ALL
Minimum age (years): 65
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Dementia is a clinical disorder characterized by progressive and permanent loss of multiple cognitive functions, especially memory, at a level that affects activities of daily living. There is no pharmacologic treatment method that can change the prognosis in dementia. The methods used today are symptomatic and cause various side effects. For this reason, non-pharmacologic approaches are on the agenda in the treatment of dementia. Among these approaches, physical activity approaches such as symptomatic treatment or exercise come to the forefront due to their prognosis-slowing effects. There are also many studies showing that dementia is directly related to physical performance and frailty. Deterioration of physical performance, increased frailty, and decreased muscle strength create a vicious circle with the prognosis of dementia. In addition, patients with dementia have balance problems due to prolonged reaction time, cognitive impairment and physical problems, and the risk of falls increases. In order to prevent the risk of falls, exercise practices are of great importance. Although the effects of aerobic exercise on dementia have been examined many times in the literature, there are very few studies examining the effects of balance exercises and combined exercises. In addition, physical characteristics such as frailty and muscle weakness, which are very common in patients with dementia, have not been evaluated as a whole in studies on patients with dementia. Therefore, this study will be conducted to comparatively examine the effects of combined aerobic exercise and balance exercises on balance and falls, frailty, muscle strength, cognitive functions, and reaction time in patients with dementia.


Eligibility criteria: Inclusion Criteria:

* Age over 65 years,
* To be able to speak and understand Turkish,
* To have at least primary education,
* Perceive and adapt to simple commands,
* Scoring between 18-23 on the standardized mini mental state assessment scale (200),
* To be able to provide independent mobilization,
* Volunteering to participate.

Exclusion Criteria:

* Rapid progression of dementia (infectious, vascular, hematologic diseases),
* Cardiac or cerebrovascular event, endocrine disorder, fluid-electrolyte imbalance or infection during the follow-up period,
* Presence of malignancy,
* Detection of a delirium picture,
* Presence of severe depression,
* Participate in a regular exercise program for at least 6 months before the study,
* Having a fracture or fracture surgery in the lower extremity within the last year,
* Any orthopedic problem that prevents him/her from exercising.

Primary outcomes:
measure: Edmonton Frailty Scale
timeFrame: Change from Baseline Edmonton Frailty Scale at 6 weeks
measure: Muscle Strength Assessment for Sarcopenia
timeFrame: Change from Baseline Muscle Strength Assessment for Sarcopenia at 6 weeks
measure: 30 Seconds Sit To Stand Test
timeFrame: Change from Baseline 30 Seconds Sit To Stand Test at 6 weeks
measure: Single Leg Stance Test
timeFrame: Change from Baseline Single Leg Stance Test at 6 weeks
measure: Tinetti Balance and Gait Assessment
timeFrame: Change from Baseline Tinetti Balance and Gait Assessment at 6 weeks
measure: Dynamic Gait Index
timeFrame: Change from Baseline Dynamic Gait Index at 6 weeks
measure: Functional Reach Test
timeFrame: Change from Baseline Functional Reach Test at 6 weeks
measure: Johns Hopkins Fall Risk Assessment Tool
timeFrame: Change from Baseline Johns Hopkins Fall Risk Assessment Tool at 6 weeks
measure: Reaction Time Test
timeFrame: Change from Baseline at 6 weeks
measure: Mini Mental State Examination
timeFrame: Change from Baseline Reaction Time Test at 6 weeks
measure: The World Health Organization Quality of Life - Old Module
timeFrame: Change from Baseline The World Health Organization Quality of Life - Old Module at 6 weeks
measure: Geriatric Depression Scale
timeFrame: Change from Baseline Geriatric Depression Scale at 6 weeks
measure: Wechsler Memory Scale
timeFrame: Change from Baseline Wechsler Memory Scale at 6 weeks
measure: Mental Rotation Test
timeFrame: Change from Baseline Mental Rotation Test at 6 weeks
measure: Spatial Orientation Test
timeFrame: Change from Baseline Spatial Orientation Test at 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ihlamur Konağı Nursing Home and Elderly Care Center
state: Çankaya
Study officials:
References: