Clinical trial NCT03351504: Solar Lighting to Reduce Indoor Air Pollution in Rural Uganda
Official title: Solar Lighting Intervention Trial to Reduce Indoor Air Pollution and Improve Adult Respiratory Health in Rural Uganda
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pollution; Exposure
Hypertension
Pollution Related Respiratory Disorder
Keywords: household air pollution
fine particulate matter
kerosene
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
Collaborators: name: Mbarara University of Science and Technology
name: Harvard School of Public Health (HSPH)
First posted: 2017-11-22
Enrollment: 80
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluates the impact of a solar lighting system on kerosene lamp use, levels of indoor air pollution, and health in women living in rural Uganda. Half of the participants will receive the lighting systems immediately, while the other half will receive them after an 18 month delay.

Detailed description: One fifth of the global population relies on kerosene lamps for lighting, yet few studies have focused on kerosene lighting as a source of indoor air pollution. In our preliminary studies performed in Uganda, we show that homes using solar lighting have much lower levels of indoor air pollution compared to homes using kerosene lighting. The primary goal of this study is to determine the extent to which solar lighting will reduce kerosene use and indoor air pollution in rural Uganda, whether this intervention improves lung health, and to identify the role bacteria in our gut have on determining whether or not people will get sick from indoor air pollution.

Eligibility criteria: Inclusion Criteria:

* Women living in Nyakabare Parish, Uganda with no prior history of chronic lung disease

Exclusion Criteria:

* Current active tuberculosis in any family member

Primary outcomes:
measure: Fine particulate matter (PM2.5) and Black Carbon
timeFrame: 48 hour
Secondary outcomes:
measure: Daily use of solar lighting system (hours per day)
timeFrame: baseline, 3 months, 6 months, 12 months after the intervention
measure: Blood pressure
timeFrame: baseline, 3 months, 6 months, 12 months after the intervention
measure: Forced Expiratory Volume in one Second (FEV1)
timeFrame: baseline, 3 months, 6 months, 12 months after the intervention
measure: Heart rate variability
timeFrame: baseline, 3 months, 6 months, 12 months after the intervention
measure: Stool microbiome
timeFrame: baseline, 3 months, 6 months, 12 months after the intervention
measure: Qualitative interviews
timeFrame: Post-intervention
measure: Respiratory symptoms
timeFrame: baseline, 3 months, 6 months, 12 months after intervention
Other outcomes:
Locations:
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Mbarara
country: Uganda
facility: Mbarara University of Science and Technology
Study officials:
affiliation: Massachusetts General Hospital
name: Peggy S Lai, MD MPH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wallach ES, Lam NL, Nuwagira E, Muyanja D, Tayebwa M, Valeri L, Tsai AC, Vallarino J, Allen JG, Lai PS. Effect of a solar lighting intervention on fuel-based lighting use and exposure to household air pollution in rural Uganda: A randomized controlled trial. Indoor Air. 2022 Feb;32(2):e12986. doi: 10.1111/ina.12986.