Clinical trial NCT04241068: A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
Official title: Phase 3b Open-Label, Multicenter, Safety Study of BIIB037 (Aducanumab) in Subjects With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Alzheimer's Disease
Lead sponsor: Biogen
Sponsor class: INDUSTRY
First posted: 2020-01-27
Enrollment: 1696
Sex: ALL
Minimum age (years): 50
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The primary objective is to evaluate the safety and tolerability of aducanumab over 100 weeks of treatment after a wash-out period imposed by discontinuation of feeder studies in participants who had previously received aducanumab (i.e. previously treated participants) or who had previously received placebo (i.e. treatment-naïve participants).


Eligibility criteria: Key Inclusion Criteria:

Core Treatment Period:

* Participant was participating in an aducanumab clinical study at the time of the announcement of early termination (feeder studies).
* Has one care partner who, in the Investigator's opinion, has adequate contact with the participant as to be able to provide accurate information about the participant's cognitive and functional abilities.

LTE Treatment Period:

* Participant must have completed the Core study period (Week 102) and adequately tolerated 10 mg/kg of aducanumab during the Core study period in the opinion of the Investigator.
* Has one informant/care partner who, in the Investigator's opinion, has frequent and sufficient contact with the participant as to be able to provide accurate information about the participant's cognitive and functional abilities.

Key Exclusion Criteria:

Core Treatment Period:

* Any medical or neurological condition (other than Alzheimer's Disease) that might be a contributing cause of the participant's cognitive impairment.
* Stroke or any unexplained loss of consciousness within 1 year prior to Screening.
* Clinically significant unstable psychiatric illness in past 6 months.
* History of unstable angina, myocardial infarction, advanced chronic heart failure, or clinically significant conduction abnormalities within 1 year prior to Screening.
* A seizure event that occurred after the last visit of the feeder study and before Screening for this study.
* Evidence of impaired liver function as shown by an abnormal liver function profile at Screening.
* History of or known seropositivity for HIV.
* Clinically significant systemic illness or serious infection within 30 days prior to or during Screening.
* Contraindications to having a brain magnetic resonance imaging (MRI).

LTE Treatment Period:

* Any medical or psychiatric contraindication or clinically significant abnormality that, in the opinion of the Investigator, will substantially increase the risk associated with the participant's enrollment in and completion of the study.

Note- Other protocol defined Inclusion/Exclusion criteria may apply.

Primary outcomes:
measure: Core Treatment Period: Number of Participants With Treatment-Emergent Adverse Events (TEAEs) and Serious TEAEs
timeFrame: From the first dose of study drug to end of follow-up (up to Week 118)
measure: Core Treatment Period: Number of Participants With AEs Leading to Treatment Discontinuation (TD) and Study Withdrawal (SW)
timeFrame: From the first dose of study drug to end of follow-up (up to Week 118)
measure: Core Treatment Period: Number of Participants With Amyloid-Related Imaging Abnormality-Edema (ARIA-E)
timeFrame: Up to Week 118
measure: Core Treatment Period: Number of Participants With Amyloid-Related Imaging Abnormality- Hemorrhage or Superficial Siderosis (ARIA-H)
timeFrame: Up to Week 118
measure: Core Treatment Period: Number of Participants With Positive Antidrug Antibodies (ADAs) in Serum
timeFrame: Up to Week 102
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Phoenix
country: United States
facility: Banner Alzheimer's Institute
state: Arizona
city: Phoenix
country: United States
facility: Dignity Health
state: Arizona
city: Sun City
country: United States
facility: Banner Sun Health Research Institute
state: Arizona
city: Tucson
country: United States
facility: Center for Neurosciences
state: Arizona
city: Fullerton
country: United States
facility: Neurology Center of North Orange County
state: California
city: Irvine
country: United States
facility: UCI MIND
state: California
city: La Jolla
country: United States
facility: University of California San Diego Medical Center
state: California
city: Laguna Hills
country: United States
facility: Senior Clinical Trials, Inc.
state: California
city: Los Angeles
country: United States
facility: USC Keck School of Medicine
state: California
city: Los Angeles
country: United States
facility: Mary S. Easton Center for Alzheimer's Disease Research, UCLA
state: California
city: Oxnard
country: United States
facility: Pacific Neuroscience Medical Group
state: California
city: Palo Alto
country: United States
facility: Stanford Hospital and Clinics
state: California
city: Redlands
country: United States
facility: Anderson Clinical Research
state: California
city: San Diego
country: United States
facility: Pacific Research Network, Inc
state: California
city: San Francisco
country: United States
facility: UCSF - Memory and Aging Center
state: California
city: Santa Ana
country: United States
facility: Syrentis Clinical Research
state: California
city: Sherman Oaks
country: United States
facility: California Neuroscience Research Medical Group Inc.
state: California
city: Aurora
country: United States
facility: University of Colorado Denver
state: Colorado
city: Centennial
country: United States
facility: IMMUNOe International Research Centers
state: Colorado
city: Fairfield
country: United States
facility: Yale University
state: Connecticut
city: New Haven
country: United States
facility: Invicro
state: Connecticut
city: New Haven
country: United States
facility: Yale University School Of Medicine
state: Connecticut
city: Norwalk
country: United States
facility: Research Center for Clinical Studies, Inc.
state: Connecticut
city: Washington
country: United States
facility: Georgetown University Clinical Research Unit (CRU)
state: District of Columbia
city: Atlantis
country: United States
facility: JEM Research
state: Florida
city: Bradenton
country: United States
facility: Bradenton Research Center, Inc
state: Florida
city: Delray Beach
country: United States
facility: Brain Matters Research
state: Florida
city: Fort Myers
country: United States
facility: Neuropsychiatric Research Center of Southwest Florida
state: Florida
city: Hollywood
country: United States
facility: Infinity Clinical Research, LLC
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Center for Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: Mayo Clinic in Florida
state: Florida
city: Miami
country: United States
facility: University of Miami
state: Florida
city: Miami
country: United States
facility: Miami Jewish Health System, Inc
state: Florida
city: Ocala
country: United States
facility: Renstar Medical Research
state: Florida
city: Orlando
country: United States
facility: Accelerated Enrollment Solutions (AES)
state: Florida
city: Orlando
country: United States
facility: Clinical Neuroscience Solutions, Inc.
state: Florida
city: Orlando
country: United States
facility: Accelerated Enrollment Solutions (AES)
state: Florida
city: Palm Beach Gardens
country: United States
facility: Palm Beach Neurological Center
state: Florida
city: Pompano Beach
country: United States
facility: Quantum Laboratories Inc.
state: Florida
city: Tampa
country: United States
facility: Axiom Clinical Research of Florida
state: Florida
city: Tampa
country: United States
facility: Stedman Clinical Trials, LLC
state: Florida
city: Tampa
country: United States
facility: USF Health Byrd Institute
state: Florida
city: Tampa
country: United States
facility: Meridien Research
state: Florida
city: West Palm Beach
country: United States
facility: Premiere Research Institute
state: Florida
city: Weston
country: United States
facility: Cleveland Clinic Florida - Weston
state: Florida
city: Atlanta
country: United States
facility: Emory University Cognitive Neurology Clinic & ADRC
state: Georgia
city: Columbus
country: United States
facility: Medical Research Health and Education Foundation, Inc
state: Georgia
city: Decatur
country: United States
facility: NeuroStudies.net, LLC
state: Georgia
city: Elk Grove Village
country: United States
facility: Alexian Brothers Medical Center - Neuroscience Research Institute
state: Illinois
city: Park Ridge
country: United States
facility: Advocate Lutheran General Hospital
state: Illinois
city: Fort Wayne
country: United States
facility: Fort Wayne Neurological Center
state: Indiana
city: Indianapolis
country: United States
facility: Indiana University School of Medicine
state: Indiana
city: Indianapolis
country: United States
facility: Josephson, Wallack, Munshower Neurology, P.C.
state: Indiana
city: Fairway
country: United States
facility: University of Kansas Medical Center Research Institute, Inc.
state: Kansas
city: Wichita
country: United States
facility: Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc.
state: Kansas
city: Lexington
country: United States
facility: Baptist Health Lexington
state: Kentucky
city: Belmont
country: United States
facility: McLean Hospital
state: Massachusetts
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center
state: Massachusetts
city: Boston
country: United States
facility: Brigham and Women's Hospital Department of Neurology
state: Massachusetts
city: Methuen
country: United States
facility: ActivMed Practices & Research, Inc.
state: Massachusetts
city: Newton
country: United States
facility: Boston Center for Memory
state: Massachusetts
city: Plymouth
country: United States
facility: Donald S. Marks, M.D., P.C.
state: Massachusetts
city: Rochester
country: United States
facility: Mayo Clinic
state: Michigan
city: Hattiesburg
country: United States
facility: Hattiesburg Clinic, PA
state: Mississippi
city: Saint Louis
country: United States
facility: Washington University
state: Missouri
city: Las Vegas
country: United States
facility: Cleveland Clinic Lou Ruvo Center for Brain Health
state: Nevada
city: Las Vegas
country: United States
facility: Las Vegas Medical Research
state: Nevada
city: Portsmouth
country: United States
facility: ActivMed Practices & Research, Inc.
state: New Hampshire
city: Toms River
country: United States
facility: Advanced Memory Research Inst. of NJ, PC
state: New Jersey
city: Albany
country: United States
facility: Albany Medical College
state: New York
city: Latham
country: United States
facility: Empire Neurology, PC
state: New York
city: New York
country: United States
facility: New York University Medical Center PRIME
state: New York
city: New York
country: United States
facility: Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC)
state: New York
city: New York
country: United States
facility: Mount Sinai School of Medicine
state: New York
city: Rochester
country: United States
facility: University of Rochester
state: New York
city: Charlotte
country: United States
facility: AMC Research, LLC
state: North Carolina
city: Raleigh
country: United States
facility: Raleigh Neurology Associates
state: North Carolina
city: Winston-Salem
country: United States
facility: Gastroenterology Associates of the Piedmont
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Health
state: North Carolina
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
city: Columbus
country: United States
facility: Ohio State University Wexner Medical Center
state: Ohio
city: Oklahoma City
country: United States
facility: Lynn Health Science Institute
state: Oklahoma
city: Allentown
country: United States
facility: Lehigh Center for Clinical Research, LLC
state: Pennsylvania
city: Jenkintown
country: United States
facility: The Clinical Trial Center, LLC
state: Pennsylvania
city: Philadelphia
country: United States
facility: Penn Memory Center
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh
state: Pennsylvania
city: Wilkes-Barre
country: United States
facility: Northeastern Pennsylvania Memory and Alzheimer's Center
state: Pennsylvania
city: East Providence
country: United States
facility: Rhode Island Mood & Memory Research Institute
state: Rhode Island
city: Providence
country: United States
facility: Rhode Island Hospital
state: Rhode Island
city: Providence
country: United States
facility: Butler Hospital
state: Rhode Island
city: Charleston
country: United States
facility: Roper St. Francis Healthcare
state: South Carolina
city: Charleston
country: United States
facility: Medical University of South Carolina (MUSC)
state: South Carolina
city: Cordova
country: United States
facility: Neurology Clinic, PC
state: Tennessee
city: Austin
country: United States
facility: Senior Adult Specialty Research
state: Texas
city: Dallas
country: United States
facility: UT Southwestern Medical Center
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine
state: Texas
city: Houston
country: United States
facility: Clinical Trial Network
state: Texas
city: Salt Lake City
country: United States
facility: University of Utah Health Sciences Center
state: Utah
city: Bennington
country: United States
facility: The Memory Clinic
state: Vermont
city: Richmond
country: United States
facility: National Clinical Research Inc.-Richmond
state: Virginia
city: Seattle
country: United States
facility: University of Washington Medical Centre
state: Washington
city: Spokane
country: United States
facility: Kingfisher Cooperative, LLC
state: Washington
city: Milwaukee
country: United States
facility: Medical College of Wisconsin, Inc.
state: Wisconsin
city: Chermside
country: Australia
facility: The Prince Charles Hospital
state: New South Wales
city: Darlinghurst
country: Australia
facility: St Vincent's Hospital Sydney
state: New South Wales
city: Erina
country: Australia
facility: Central Coast Neurosciences Research (Erina)
state: New South Wales
city: Macquarie Park
country: Australia
facility: KaRa Institute of Neurological Diseases
state: New South Wales
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: Heidelberg West
country: Australia
facility: Austin Health
state: Victoria
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Nedlands
country: Australia
facility: Australian Alzheimer's Research Foundation
state: Western Australia
city: Graz
country: Austria
facility: LKH - Universitaetsklinikum Graz
city: Salzburg
country: Austria
facility: Christian-Doppler-Klinik - Universitätsklinikum Salzburg
city: Vienna
country: Austria
facility: AKH - Medizinische Universität Wien
city: Brasschaat
country: Belgium
facility: AZ Klina
city: Brugge
country: Belgium
facility: AZ Sint-Jan
city: Brussel
country: Belgium
facility: Universitair Ziekenhuis Brussel
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent
city: Kortrijk
country: Belgium
facility: AZ Groeninge
city: Leuven
country: Belgium
facility: UZ Leuven
city: Roeselare
country: Belgium
facility: AZ Delta
city: Calgary
country: Canada
facility: University of Calgary - Heritage Medical Research Clinic
state: Alberta
city: Kamloops
country: Canada
facility: The Medical Arts Health Research Group
state: British Columbia
city: Penticton
country: Canada
facility: The Medical Arts Health Research Group
state: British Columbia
city: Vancouver
country: Canada
facility: UBC Hospital
state: British Columbia
city: West Vancouver
country: Canada
facility: Medical Arts Health Research Group
state: British Columbia
city: Halifax
country: Canada
facility: True North Clinical Research - Halifax Inc.
state: Nova Scotia
city: Kentville
country: Canada
facility: True North Clinical Research
state: Nova Scotia
city: London
country: Canada
facility: St. Joseph's HC- Parkwood Institute
state: Ontario
city: Ottawa
country: Canada
facility: Bruyere Continuing Care
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Centre - Redefining Healthy Aging
state: Ontario
city: Toronto
country: Canada
facility: Toronto Memory Program (Neurology Research Inc.)
state: Ontario
city: Toronto
country: Canada
facility: Toronto Sunnybrook Hospital
state: Ontario
city: Toronto
country: Canada
facility: Toronto Western Hospital
state: Ontario
city: Gatineau
country: Canada
facility: Clinique de la Memoire de l'Outaouais
state: Quebec
city: Greenfield Park
country: Canada
facility: Institut et Clinique MoCA
state: Quebec
city: Montréal
country: Canada
facility: Montreal Neurological Institute Clinical Research Unit
state: Quebec
city: Quebec
country: Canada
facility: CHU de Quebec - Hôpital de l' Enfant Jésus
city: Aalborg
country: Denmark
facility: CCBR - Ålborg - DK
city: København
country: Denmark
facility: Danish Dementia Research Centre
city: Vejle
country: Denmark
facility: CCBR - Vejle - DK
city: Helsinki
country: Finland
facility: Terveystalo Ruoholahti
city: Kuopio
country: Finland
facility: Itä-Suomen yliopisto, Aivotutkimusyksikkö
city: Turku
country: Finland
facility: CRST, Clinical Research Services Turku
city: Strasbourg Cedex
country: France
facility: CHU Strasbourg - Hôpital Hautepierre
state: Bas Rhin
city: Marseille cedex 05
country: France
facility: Hôpital de la Timone
state: Bouches-du-Rhône
city: Bordeaux Cedex
country: France
facility: Groupe Hospitalier Pellegrin - Hôpital Pellegrin
state: Gironde
city: Toulouse cedex 9
country: France
facility: Hopital Purpan
state: Haute Garonne
city: Toulouse Cedex 9
country: France
facility: Hôpital La Grave
state: Haute Garonne
city: Montpellier
country: France
facility: Hopital Gui de Chauliac
state: Herault
city: Rennes cedex 9
country: France
facility: CHU Rennes - Pontchaillou
state: Ille Et Vilaine
city: Nantes cedex 1
country: France
facility: CHU Nantes - Hopital Nord Laënnec
state: Loire Atlantique
city: Reims
country: France
facility: CHU Reims - Hôpital Maison Blanche
state: Marne
city: Lille Cedex
country: France
facility: CHU Lille - Hopital Roger Salengro
state: Nord
city: Paris cedex 10
country: France
facility: Hôpital Lariboisière
state: Paris
city: Bron Cedex
country: France
facility: CHU de Lyon - Hopital Neurologique Pierre Wertheimer
state: Rhone
city: Villeurbanne
country: France
facility: Hôpital des Chapennes
state: Rhone
city: Paris
country: France
facility: Groupe Hospitalier Pitie-Salpetriere
city: Paris
country: France
facility: Hôpital Broca
city: Böblingen
country: Germany
facility: Studienzentrum fur Neurologie und Psychiatrie
state: Baden Wuerttemberg
city: Mannheim
country: Germany
facility: ISPG - Institut fuer Studien zur Psychischen Gesundheit
state: Baden Wuerttemberg
city: Stuttgart
country: Germany
facility: mind mvz GmbH
state: Baden Wuerttemberg
city: Ulm
country: Germany
facility: Neuropoint Studienzentrum
state: Baden Wuerttemberg
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm
state: Baden Wuerttemberg
city: Bayreuth
country: Germany
facility: Klinikum Bayreuth GmbH- Hohe Warte
state: Bayern
city: Günzburg
country: Germany
facility: Bezirkskrankenhaus Guenzburg
state: Bayern
city: Munich
country: Germany
facility: Klinikum rechts der Isar der TU Muenchen
state: Bayern
city: München
country: Germany
facility: Institut fuer Schlaganfall- und Demenzforschung (ISD)
state: Bayern
city: Unterhaching
country: Germany
facility: Neuropraxis Muenchen Sued
state: Bayern
city: Erbach
country: Germany
facility: Neuro Centrum Science GmbH, Geschaftführende Gesellschafterin Barbara Unsorg und Prüfarzt Dr. med. G
state: Hessen
city: Kassel
country: Germany
facility: Neurologische Gemeinschaftspraxis Kassel
state: Hessen
city: Hannover
country: Germany
facility: Klinische Forschung Hannover-Mitte GmbH
state: Niedersachsen
city: Aachen
country: Germany
facility: Universitaetsklinikum Aachen AOeR
state: Nordrhein Westfalen
city: Bielefeld
country: Germany
facility: Neurozentrum Bielefeld
state: Nordrhein Westfalen
city: Duesseldorf
country: Germany
facility: Universitaetsklinikum Duesseldorf AoeR
state: Nordrhein Westfalen
city: Koeln
country: Germany
facility: Universitaetsklinikum Koeln
state: Nordrhein Westfalen
city: Siegen
country: Germany
facility: Zentrum f. Neurologisch- Psychiatrische Studien und Begutachtung
state: Nordrhein Westfalen
city: Altenburg
country: Germany
facility: Klinikum Altenburger Land GmbH
state: Thueringen
city: Berlin
country: Germany
facility: Emovis GmbH
city: Berlin
country: Germany
facility: Neurologie im Tempelhofer Hafen
city: Berlin
country: Germany
facility: Charite Universitaetsmedizin Berlin - Campus Berlin Buch
city: Ponderano
country: Italy
facility: Ospedale degli Infermi
state: Biella
city: Tricase
country: Italy
facility: Azienda Ospedaliera Card. G. Panico
state: Lecce
city: Monza
country: Italy
facility: ASST di Monza
state: Milano
city: Cefalù
country: Italy
facility: Fondazione Istituto G.Giglio di Cefalù
state: Palermo
city: Brescia
country: Italy
facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
city: Genova
country: Italy
facility: Azienda Ospedaliero Universitaria San Martino
city: Milano
country: Italy
facility: Ospedale San Raffaele
city: Milano
country: Italy
facility: Fondazione IRCCS Istituto Neurologico Carlo Besta
city: Napoli
country: Italy
facility: AOU dell'Università degli studi della Campania Luigi Vanvitelli
city: Perugia
country: Italy
facility: Azienda Ospedaliera e Universitaria di Perugia
city: Pisa
country: Italy
facility: Azienda Ospedaliero Universitaria Pisana
city: Roma
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
city: Roma
country: Italy
facility: Fondazione Santa Lucia IRCCS
city: Salerno
country: Italy
facility: Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona
city: Siena
country: Italy
facility: A.O.U. Senese Policlinico Santa Maria alle Scotte
city: Obu-shi
country: Japan
facility: Research Site
state: Aichi-Ken
city: Chiba-shi
country: Japan
facility: Research Site
state: Chiba-Ken
city: Chiba-shi
country: Japan
facility: Research Site
state: Chiba-Ken
city: Inzai-shi
country: Japan
facility: Research Site
state: Chiba-Ken
city: Toon-shi
country: Japan
facility: Research Site
state: Ehime-Ken
city: Fukuoka-shi
country: Japan
facility: Research Site
state: Fukuoka-Ken
city: Kurume-shi
country: Japan
facility: Research Site
state: Fukuoka-Ken
city: Aizu-Wakamatsu
country: Japan
facility: Research Site
state: Fukushima-Ken
city: Otake-shi
country: Japan
facility: Research Site
state: Hiroshima-Ken
city: Asahikawa-shi
country: Japan
facility: Research Site
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Research Site
state: Hokkaido
city: Amagasaki-shi
country: Japan
facility: Research Site
state: Hyogo-Ken
city: Himeji-shi
country: Japan
facility: Research Site
state: Hyogo-Ken
city: Himeji-shi
country: Japan
facility: Research Site
state: Hyogo-Ken
city: Kobe-shi
country: Japan
facility: Research Site
state: Hyogo-Ken
city: Kita-gun
country: Japan
facility: Research Site
state: Kagawa-Ken
city: Kamakura-shi
country: Japan
facility: Research Site
state: Kanagawa-Ken
city: Kyoto-shi
country: Japan
facility: Research Site
state: Kyoto-Fu
city: Kyoto-shi
country: Japan
facility: Research Site
state: Kyoto-Fu
city: Tsu-shi
country: Japan
facility: Research Site
state: Mie-Ken
city: Togitsu
country: Japan
facility: Research Site
state: Nagasaki-Ken
city: Nagaoka-shi
country: Japan
facility: Research Site
state: Niigata-Ken
city: Yufu-shi
country: Japan
facility: Research Site
state: Oita-Ken
city: Kurashiki-shi
country: Japan
facility: Research Site
state: Okayama-Ken
city: Okayama-shi
country: Japan
facility: Research Site
state: Okayama-Ken
city: Tsukuba
country: Japan
facility: Research Site
state: Okayama-Ken
city: Osaka-shi
country: Japan
facility: Research Site
state: Osaka-Fu
city: Suita-shi
country: Japan
facility: Research Site
state: Osaka-Fu
city: Iruma-gun
country: Japan
facility: Research Site
state: Saitama-Ken
city: Kasukabe-shi
country: Japan
facility: Research Site
state: Saitama-Ken
city: Shizuka-shi
country: Japan
facility: Research Site
state: Shizuoka-Ken
city: Shizuoka-shi
country: Japan
facility: Research Site
state: Shizuoka-Ken
city: Bunkyo-ku
country: Japan
facility: Research Site
state: Tokyo-To
city: Kiyose-shi
country: Japan
facility: Research Site
state: Tokyo-To
city: Kodaira-shi
country: Japan
facility: Research Site
state: Tokyo-To
city: Yamagata-shi
country: Japan
facility: Research Site
state: Yamagata-Ken
city: Incheon
country: Korea, Republic of
facility: Inha University Hospital
state: Gyeonggi-do
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Amsterdam
country: Netherlands
facility: Brain Research Center
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis, Molengracht
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum
city: Bialystok
country: Poland
facility: Podlaskie Centrum Psychogeriatrii
city: Bydgoszcz
country: Poland
facility: PALLMED Sp. z o.o.
city: Gdansk
country: Poland
facility: Klinika Psychiatrii Doroslych UCK
city: Katowice
country: Poland
facility: Novo-Med Zielinski i wspolnicy Sp. j.
city: Lodz
country: Poland
facility: SPZOZ Centralny Szpital Kliniczny UM w Lodzi
city: Lublin
country: Poland
facility: Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
city: Poznan
country: Poland
facility: NZOZ "NEURO-KARD", "Ilkowski i Partnerzy" Sp. Partn. Lek.
city: Siemianowice Slaskie
country: Poland
facility: Neuro-Care Gabriela Klodowska
city: Sopot
country: Poland
facility: Centrum Medyczne Senior
city: Szczecin
country: Poland
facility: Osrodek Badan Klinicznych EUROMEDIS
city: Warszawa
country: Poland
facility: Centrum Medyczne NeuroProtect
city: Wroclaw
country: Poland
facility: NZOZ Wroclawskie Centrum Alzheimerowskie
city: Braga
country: Portugal
facility: Hospital de Braga
city: Coimbra
country: Portugal
facility: Centro Hospitalar e Universitário de Coimbra E.P.E - Hospitais da Universidade de Coimbra
city: Loures
country: Portugal
facility: Hospital Beatriz Ângelo
city: Torres Vedras
country: Portugal
facility: CNS-Campus Neurologico Senior
city: Elche
country: Spain
facility: Hospital General Universitario de Elche
state: Alicante
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia
state: Córdoba
city: San Sebastian
country: Spain
facility: Policlinica Gipuzkoa
state: Guipuzcoa
city: Pamplona
country: Spain
facility: Clinica Universidad de Navarra
state: Navarra
city: Getxo
country: Spain
facility: CAE Oroitu
state: Vizcaya
city: Barcelona
country: Spain
facility: Hospital del Mar
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
city: Barcelona
country: Spain
facility: Fundacio ACE
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona
city: Lleida
country: Spain
facility: Hospital Universitari de Santa Maria
city: Madrid
country: Spain
facility: Complejo Hospitalario Ruber Juan Bravo
city: Sevilla
country: Spain
facility: Hospital Victoria Eugenia
city: Valencia
country: Spain
facility: Hospital Universitario Dr. Peset
city: Valencia
country: Spain
facility: Hospital Universitari i Politecnic La Fe
city: Malmö
country: Sweden
facility: Skånes Universitetssjukhus
city: Mölndal
country: Sweden
facility: Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus
city: Stockholm
country: Sweden
facility: Karolinska Universitetssjukhuset, Huddinge
city: Uppsala
country: Sweden
facility: Akademiska Sjukhuset
city: Biel/Bienne
country: Switzerland
facility: Spitalzentrum Biel
city: Genève
country: Switzerland
facility: Hôpitaux Universitaires de Geneve- HUG
city: Lausanne
country: Switzerland
facility: Centre Hospitalier Universitaire Vaudois
city: Lugano
country: Switzerland
facility: Ospedale Regionale di Lugano
city: Schlieren
country: Switzerland
facility: Institut fur Regenerative Medizin-IREM Universitat Zurich, Campus Schlieren
city: Changhua
country: Taiwan
facility: Changhua Christian Medical Foundation Changhua Christian Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taoyuan City
country: Taiwan
facility: Chang Gung Memorial Hospital, Linkou
city: London
country: United Kingdom
facility: Re:Cognition Health Ltd (London)
state: Greater London
city: London
country: United Kingdom
facility: Charing Cross Hospital
state: Greater London
city: London
country: United Kingdom
facility: The National Hospital for Neurology and Neurosurgery Centre
state: Greater London
city: Manchester
country: United Kingdom
facility: Manchester Royal Infirmary
state: Greater Manchester
city: Edinburgh
country: United Kingdom
facility: The University of Edinburgh
state: Lothian Region
city: Bath
country: United Kingdom
facility: The RICE Centre
state: Somerset
city: Glasgow
country: United Kingdom
facility: Queen Elizabeth University Hospital Campus
state: Strathclyde
city: Motherwell
country: United Kingdom
facility: Glasgow Memory Clinic Ltd
state: Strathclyde
city: Dundee
country: United Kingdom
facility: Ninewells Hospital
state: Tayside Region
city: Newcastle upon Tyne
country: United Kingdom
facility: Newcastle University
state: Tyne & Wear
Study officials:
affiliation: Biogen
name: Medical Director
role: STUDY_DIRECTOR
References: