Clinical trial NCT06622343: Predictive Modeling of Necrotizing Skin Infections in Snakebite Patients
Official title: Risk Factor Analysis and Predictive Modeling for Necrotizing Skin Infections in Venomous Snakebite Patients: A Multicenter Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Necrotizing Skin Infections
Snakebite Envenomation
Keywords: Snakebite
Necrotizing Infection
Risk Factors
Predictive Modeling
Venomous Snakes
D-dimer
Snakebite Severity Score
Blood Glucose Levels
Lead sponsor: Guangzhou Institute of Respiratory Disease
Sponsor class: OTHER
Collaborators: name: Central People's Hospital of Zhanjiang
name: Affiliated Hospital of Guangdong Medical University
First posted: 2024-10-02
Enrollment: 99
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study includes adult patients (aged 18 years and older) who were treated for venomous snakebites at three hospitals in Guangdong Province. The population consists of both male and female patients with confirmed envenomation and sufficient medical records for analysis.

Brief summary: This multicenter retrospective study aims to identify the risk factors associated with necrotizing skin infections following venomous snakebites and to develop a predictive model. Clinical data from 99 patients treated between January 2020 and April 2024 at three hospitals in Guangdong Province, China, were analyzed.

Detailed description: Venomous snakebites are a significant public health issue, particularly in tropical and subtropical regions like southern China. Necrotizing skin infections are a severe but relatively rare complication of venomous snakebites, often resulting from delayed treatment and bacterial invasion. This study retrospectively analyzed clinical data from 99 patients with venomous snakebites treated at three hospitals in Guangdong Province between January 2020 and April 2024. The primary objective was to identify the major risk factors associated with the development of necrotizing skin infections and to build a predictive model to assist in clinical decision-making.

The study included male and female patients aged 14 years and older. Patients with incomplete medical records, long-term use of immunosuppressants, or underlying immunodeficiency diseases were excluded. Multivariate logistic regression identified the Snakebite Severity Score (SSS), blood glucose levels, and D-dimer levels as significant independent predictors of necrotizing infections.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of venomous snake bites confirmed according to major international clinical guidelines and expert consensus.
* Availability of complete case data.
* Provision of written informed consent by the patients or their legal guardians.

Exclusion Criteria:

* Age less than 14 years.
* Long-term use of immunosuppressants or corticosteroids.
* Presence of concurrent immunodeficiency diseases (e.g., HIV positive).
* Severe malnutrition.
* Incomplete medical records.

Primary outcomes:
measure: Incidence of Necrotizing Skin Infections
timeFrame: 30 days from admission or until discharge.
Secondary outcomes:
measure: Hospital Length of Stay
timeFrame: From hospital admission until discharge, typically ranging between 1 and 30 days.
Other outcomes:
Locations:
city: Zhanjiang
country: China
facility: Affiliated Hospital of Guangdong Medical University
state: Guangdong
Study officials:
References: