Clinical trial NCT03321110: Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes
Official title: Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes From Different Sports: Cross-sectional, Interventional, and Follow-up Studies
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Athlete
Lead sponsor: Chung Shan Medical University
Sponsor class: OTHER
First posted: 2017-10-25
Enrollment: 43
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: placebo-control
Primary purpose: BASIC_SCIENCE

Brief summary: The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day).

Detailed description: The long-term high-amount and -intensity exercise training could cause oxidative damage, muscle impairment, inflammation and exercise fatigue to athletes easily. Such above conditions will affect the exercise performances and health of athletes. The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day). Eventually, these results of this study can provide the information for the known to improve the oxidative stress, anti-oxidation and inflammation internal to the bodies of athletes for various competitions. As a consequence, the athletic performances can be further enhanced.

Eligibility criteria: Inclusion Criteria:

* Athletes (soccer and taekwondo players)

Exclusion Criteria:

* Antioxidant vitamins users
* Statins or Aspirin therapy.

Primary outcomes:
measure: malondialdehyde (MDA)
timeFrame: 12 weeks
Secondary outcomes:
measure: Antioxidant capacity
timeFrame: 12 weeks
measure: high sensitivity C-reactive protein (hs-CRP)
timeFrame: 12 weeks
measure: creatine kinase (CK)
timeFrame: 12 weeks
measure: Lactate dehydrogenase (LDH)
timeFrame: 12 weeks
measure: one-repetition maximum (1-RM)
timeFrame: 12 weeks
measure: Glucose
timeFrame: 12 weeks
measure: HbA1C
timeFrame: 12 weeks
measure: Insulin
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: Chung Shan Medical University
Study officials:
References: