Clinical trial NCT03347643: The Effectiveness of tDCS on Internet Game Addiction
Official title: Randomized Double-blind Clinical Trial to Evaluate the Effectiveness of Transcranial Direct Current Stimulation (tDCS) on Internet Game Addiction
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Addiction
Internet Gaming Disorder
Keywords: Internet game addiction
Internet gaming disorder
transcranial direct current stimulation
response inhibition
craving
cue reactivity
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: National Research Foundation of Korea
name: SMG-SNU Boramae Medical Center
First posted: 2017-11-20
Enrollment: 31
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Patients with internet gaming disorder will be randomly allocated into 1) actual real stimulation with tDCS group, and 2) sham stimulation with tDCS group.
Primary purpose: TREATMENT

Brief summary: In this study, the investigators aimed to investigate the effect of transcranial direct current stimulation (tDCS) on clinical status of Internet game addiction. The clinical status of Internet game addiction includes severity of addiction symptom, subjective craving for gaming, response inhibition and cue reactivity. The investigators hypothesized that real stimulation with tDCS on the dorsolateral prefrontal cortex will have higher effectiveness on severity of addiction symptom, subjective craving for gaming, response inhibition and cue reactivity rather than sham stimulation with tDCS.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of Internet gaming disorder based on diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM)-5.

Exclusion Criteria:

* History of seizure
* History of significant head injury
* Mental retardation
* Schizophrenia
* History of stroke

Primary outcomes:
measure: Young Internet Addiction Test (Y-IAT)
timeFrame: baseline
measure: Young Internet Addiction Test (Y-IAT)
timeFrame: 1 week
measure: Young Internet Addiction Test (Y-IAT)
timeFrame: 5 week
measure: Young Internet Addiction Test (Y-IAT)
timeFrame: 25 week
Secondary outcomes:
measure: Direction error and successful stop ratio in the Stop signal task
timeFrame: baseline, 5 weeks, 25 weeks
measure: Barratt impulsiveness scale-11
timeFrame: baseline, 5 weeks, 25 weeks
measure: Anti-saccade error rate in the attentional bias task
timeFrame: baseline, 5 weeks, 25 weeks
measure: Late positive potential in the cue reactivity event-related potential
timeFrame: baseline, 5 weeks, 25 weeks
measure: Visual analogue scale
timeFrame: baseline, 1 week, 5 weeks, 25 weeks
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: SMG-SNU Boramae Medical Center
Study officials:
affiliation: SMG-SNU Boramae Medical Center
name: Jung-Seok Choi, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lee JY, Jang JH, Choi AR, Chung SJ, Kim B, Park M, Oh S, Jung MH, Choi JS. Neuromodulatory Effect of Transcranial Direct Current Stimulation on Resting-State EEG Activity in Internet Gaming Disorder: A Randomized, Double-Blind, Sham-Controlled Parallel Group Trial. Cereb Cortex Commun. 2021 Jan 4;2(1):tgaa095. doi: 10.1093/texcom/tgaa095. eCollection 2021.