louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05537012: Incidence of Unresectable Cases of Cervical Cancer
Official title: Incidence of Unresectable Cases of Cervical Cancer in Gyne-oncology Unit of Alexandria University Hospital and Its Relation to Pathological Types, Grading and Lymph Vascular Space Invasion
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cervical Cancer
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2022-09-13
Enrollment: 70
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: random cases of cervical cancer

Brief summary: Objective : to calculate the incidence of unresectable cases of cervical cancer in gyne-oncology unit of Alexandria university hospital and to indentify its relation to pathological types, grading and lymph vascular space invasion.

Patients and methods: 70 cases of cervical cancer diagnosed by biopsy taking and histopathological examination will be included in the study, clinicoradiological staging was done to all cases to calculate the incidence of unresectable cases and to indentify its relation to pathological types, grading and lymph vascular space invasion


Eligibility criteria: Inclusion Criteria:

* cervical cancer

Exclusion Criteria: none

-

Primary outcomes:
measure: clinical and radiological staging
timeFrame: 10 days
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Hossam Hassan El Sokkary
Study officials:
References:
Clinical trial NCT01638312: Development of Method of Fructose Identification in Urine to Detect the Viral Infection
Official title: The Development of Fast and Simple Method of Fructose Identification in Urine to Detect the Viral Infection in Early Stage
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Human Immunodeficiency Virus
Keywords: HIV, fructose
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
First posted: 2012-07-11
Enrollment: 50
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: the person who has HIV infection

Brief summary: The goal of this research is the attempt to implement a new research method based on modern electrochemistry successes, in particular the development of the polarographic method of fructose and fructose diphosphate identification and its implementation to detect the viral infection in early stage. There will be 20 samples from the HIV-infected patients and 30 samples from the heath controls. The study will collect 10ml urine and examined fructose and fructose-diphosphate using the polarographic method.

Detailed description: The goal of this research is the attempt to implement a new research method based on modern electrochemistry successes, in particular the development of the polarographic method of fructose and fructose diphosphate identification and its implementation to detect the viral infection in early stage.

Eligibility criteria: Inclusion Criteria:

* HIV infection

Exclusion Criteria:

* who are in highly active antiretroviral therapy(HARRT) therapy

Primary outcomes:
measure: Fructose Identification in Urine to Detect the Viral Infection : Number of Participants With Positive and Negative Waveform
timeFrame: Participants provided urine samples once
Secondary outcomes:
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: Tropical Medicine Center, Kaohsiung Medical University Chung-Ho Memorial Hospital
Study officials:
affiliation: The Medicines Company
name: JihJin Tsai, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04555512: A Study to Compare the Effectiveness of Different High-intensity Interval Training Programs in Cardiac Rehabilitation
Official title: Efficacy of Prescription Methods for High-intensity Interval Training in Patients Enrolled in Outpatient Cardiac Rehabilitation
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cardiac Rehabilitation
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2020-09-18
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen.


Eligibility criteria: Inclusion Criteria:

* Adult 18 years and older.
* English speaking.
* Able to provide consent.
* Has a qualifying indication for center-based cardiac rehabilitation that is non-surgical (i.e., Acute coronary syndrome, myocardial infarction, percutaneous coronary intervention, and stable angina).

Exclusion Criteria:

* Participants referred to cardiac rehabilitation following coronary artery bypass surgery, heart valve repair/replacement, heart transplant, or those with ventricular assist devices.
* Patients who are unable to engage in a regularly structured exercise training program as part of a clinically indicated center-based outpatient cardiac rehabilitation program are not eligible.
* Patients unable/unwilling to provide informed consent will not be enrolled.
* Patients identified as having a contraindication to high intensity exercise.

Primary outcomes:
measure: Change in cardiorepiratory fitness
timeFrame: Pre and post study completion, approximately 12 weeks
Secondary outcomes:
measure: Change in oxygen uptake response time
timeFrame: Weekly, over 12 weeks
measure: Change in locomotor muscle oxygenation
timeFrame: Pre and post study completion, 12 weeks
measure: Change in metaboreflex stimulation
timeFrame: Pre and post study completion, 12 weeks
measure: Changes in mechanoreflex stimulation and sensitization
timeFrame: Pre and post study completion, 12 weeks
measure: Change in cardiac function
timeFrame: Pre and post study completion, 12 weeks
measure: Change in body composition
timeFrame: Pre and post study completion, 12 weeks
measure: Change in blood pressure
timeFrame: Pre and post study completion, 12 weeks
measure: Change in blood lipids
timeFrame: Pre and post study completion, 12 weeks
measure: Change in physical activity
timeFrame: Pre and post study completion, 12 weeks
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Amanda R Bonikowske, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02674412: Buspirone for Functional Dysphagia
Official title: Placebo-controlled, Randomized, Double-blind, Cross-over Style Trial of Buspirone in Functional Dysphagia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Functional Dysphagia
Ineffective Esophageal Motility
Lead sponsor: The Cleveland Clinic
Sponsor class: OTHER
First posted: 2016-02-04
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This study evaluates the utility of buspirone in patients who have a diagnosis of functional dysphagia. All participants will be randomized to receive either a placebo pill or buspirone. Subsequently, we will evaluate whether their swallowing is improved. Participants who were randomized to receive placebo will then receive buspirone and those who were receiving buspirone will receive placebo. We will again evaluate whether their swallowing improved.

Detailed description: Buspirone helps to modulate molecules which can affect the activity of the muscles in the esophagus. Studies in the past have shown that in healthy people, buspirone can improve the vigor with which the esophagus squeezes to propel food into the stomach. In patients with functional dysphagia, the esophagus muscles may be weak (as defined by manometry).

Our two phase study will evaluate both symptoms of difficulty swallowing and the vigor with which the esophagus propels a bolus in patients after they 1) receive placebo pills and 2) receive buspirone pills.

We hypothesize that the placebo pills will not affect the vigor of the muscles or the symptoms of difficulty swallowing, but that buspirone will improve both outcomes.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of IEM per Chicago Classification, v3.0 criteria - as noted above
* Esophagogastroduodenoscopy (EGD) negative for mechanical obstruction
* Esophageal biopsies negative for eosinophilic esophagitis

Exclusion Criteria:

* Pregnant women
* Prisoners
* Currently on other serotonin modulating medications

Primary outcomes:
measure: Change in Distal Contractile Index (DCI) on High Resolution Esophageal Manometry
timeFrame: Change in the score from Baseline to 14 days
Secondary outcomes:
measure: Change in Gastroesophageal Reflux Disease - Health Related Quality Questionnaire Score
timeFrame: Change in the score from Baseline to 14 days
measure: Change in Percentage of Normal Swallows Recorded in a Series of 10 Measured Swallows.
timeFrame: 14 days
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03928912: Risk Factors for Post-Operative Nonunion of Tibial Shaft Fractures Based on a Path Analysis Model
Official title: Risk Factors for Post-Operative Nonunion of Tibial Shaft Fractures Based on a Path Analysis Model: A Case-Control Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nonunion of Fracture of Tibia (Diagnosis)
Keywords: nonunion
tibial shaft fracture
path analysis model
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2019-04-26
Enrollment: 234
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The population came from The Second Affiliated Hospital of Zhejiang University.

Brief summary: Tibial shaft fractures is common long tubular fracture that account for about 13.7% of all fractures. And the incidence of nonunion of tibial shaft fracture varied from 1% to 80%. This study aimed to confirm the risk factors of nonunion of tibial shaft fracture. Moreover, the investigators hope to establish the clinical pathway of various risk factors for fracture nonunion and affirm the importance of different risk factors.

Detailed description: Tibial shaft fractures is common long tubular fracture that account for about 13.7% of all fractures. And the incidence of nonunion of tibial shaft fracture varied from 1% to 80%. The investigators retrospectively analyzed the demographics of these participants in our hospital that occur long tubular fracture. One group is participants that existed fracture nonunion. And the other group is the participants that did not exist fracture nonunion. The investigators recorded twelve variables and confirm the risk factors by uni-variate Logistic regression analysis. Moreover, the investigators hope to establish the clinical pathway of various risk factors for fracture nonunion and affirm the importance of different risk factors.

Eligibility criteria: Inclusion Criteria:

* The tibial shaft fracture was caused by trauma.

Exclusion Criteria:

* The tibial shaft fracture was caused by tumor, infection and other reasons.

Primary outcomes:
measure: the Gustilo type of the open fracture
timeFrame: the outcome of the Gustilo type can acquire within 1 week.
Secondary outcomes:
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Institutional Review Board of The Second Affiliated Hospital of Zhejiang University School of Medicine
state: Zhejiang
Study officials:
affiliation: Zhejiang University
name: Jian'an Wang, Ph.D
role: STUDY_CHAIR
References:
Clinical trial NCT04780412: Efficacy of Misoprostol in Prevention of Neonatal Respiratory Morbidity in Parturient at Early Term Elective Caesarian Section
Official title: Efficacy of Misoprostol in Prevention of Neonatal Respiratory Morbidity in Parturient at Early Term Elective Caesarian Section
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Transient Tachypnea of the Newborn
Neonatal Respiratory Distress
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2021-03-03
Enrollment: 210
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Neonatal respiratory morbidities represent a common group of post natal complications including respiratory distress syndrome, transient tachypnea of newborn, and persistent pulmonary hypertension of newborn.

It is thought that preoperative vaginal misoprostol administration may decrease the incidence of neonatal respiratory morbidity especially transient tachypnea of newborn. And therefore, it may decrease the incidence of admission to neonatal intensive care units for respiratory causes.


Eligibility criteria: Inclusion Criteria:

* Age: 18 years or more.
* Early term singleton pregnancy.
* Elective caesarian section at (37 - 38+6) weeks of gestation.
* Any indication for lower uterine segment caesarian section other than labor (as malpresentations, severe preeclampsia, placenta previa with no previous bleeding attacks, Diabetes Mellitus, macrosomic fetus, non reassuring cardiotocogram (CTG), and fetal growth restriction).
* Informed written consent signed by the participating pregnant woman.

Exclusion Criteria:

* Women having any contraindication to Prostaglandin E1 as hypersensitivity, respiratory disease (especially bronchial asthma), or glaucoma.
* Any mental problems that block understanding of the nature and all the possible consequences of the procedure and the study.
* Pregnancies of known fetal diseases or chromosomal abnormalities.
* Non-singleton pregnancies.
* Emergency caesarian section as in ruptured membrane and women in labor pain.

Primary outcomes:
measure: incidence of neonatal respiratory morbidity (NRM)
timeFrame: up to 24 hours after birth
Secondary outcomes:
measure: Neonatal intensive care unit (NICU) admission
timeFrame: up to 24 hours after birth
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University - Faculty of Medicine
Study officials:
affiliation: Ain Shams University - Faculty of Medicine
name: Samar A. Kandeel
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02960412: Effect of Furosemide on Confirmation of Ureteral Patency During Routine Cystoscopy
Official title: Randomized Controlled Trial Evaluating Effect of Furosemide on Confirmation of Ureteral Patency During Routine Cystoscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Cystoscopy
Lead sponsor: University of South Florida
Sponsor class: OTHER
First posted: 2016-11-09
Enrollment: 150
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This study evaluates if administration of IV furosemide leads to expedited confirmation of ureteral patency when compared to placebo (IV saline) in routine cystoscopy performed after urogynecologic surgery.

Detailed description: Cystoscopy is performed routinely after urogynecologic surgery to ensure there was no injury to the urinary tract (urethra, bladder, or ureters). In order to confirm that no damage occurred to the ureters, a jet of urine must be visualized from each ureteral opening.

The time it takes to confirm this ureteral patency is variable and some sources suggest using furosemide to decrease the time it takes to see these jets. This study will evaluate what effect, if any, this medicine has on time to confirming ureteral patency.

Eligibility criteria: Inclusion Criteria:

* Undergoing any urogynecologic surgery
* No allergy or contraindication to receiving furosemide
* Normal Creatinine/glomerular filtration rate

Exclusion Criteria:

* Unable to consent, including if non English speaking
* Allergy or contraindication to receiving furosemide
* Intraoperative injury to the lower urinary tract

Primary outcomes:
measure: time to ureteral patency
timeFrame: intra-operative
Secondary outcomes:
measure: adverse effects from furosemide administration
timeFrame: immediately post operative (1-3 days post operatively)
Other outcomes:
Locations:
city: Tampa
country: United States
facility: Tampa General Hospital
state: Florida
Study officials:
References:
citation: Patton S, Tanner JP, Prieto I, Jackson E, Greene K, Bassaly R, Wyman AM. Furosemide Use and Time to Confirmation of Ureteral Patency During Intraoperative Cystoscopy: A Randomized Controlled Trial. Obstet Gynecol. 2019 Apr;133(4):669-674. doi: 10.1097/AOG.0000000000003155.
Clinical trial NCT04212312: Single Versus Repeat Betamethasone in Twin Pregnancies
Official title: Repeat Versus Single Course of Betamethasone in Twin Pregnancies
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Twin; Complicating Pregnancy
Keywords: Betamethasone
Twin pregnancy
Repeat course
Single course
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2019-12-26
Enrollment: 2000
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pregnant women carrying twins, and who received antenatal Betamethasone between 24-34 weeks' gestation for threatened preterm labor.

Brief summary: Thus far no robust data exist as to the effect of repeted course of antenatal corticosteroids in twin pregnancies. The investigators hypothesized that repeat course of betamethasone would further reduce neonatal morbidity in twins born before 34 weeks' gestation when compared with single dose.

Detailed description: Observational data suggest benefits in multiple gestations exposed to antenatal corticosteroids, although these studies have not consistently reported a statistical benefit or the benefits achieved in singletons. Nevertheless, based on the improved outcomes reported in singleton gestations, one course of antenatal corticosteroids is administered to all patients who are between 24 weeks and 34 weeks of gestation and at risk of delivery within 7 days, irrespective of the fetal number. Moreover, "a repeat course" of antenatal corticosteroids should also be considered in women who are less than 34 weeks of gestation who have an imminent risk of preterm delivery within the next 7 days, and whose prior course of antenatal corticosteroids was administered more than 14 days previously, again, irrespective of the fetal number.

The objective of the current study is to evaluate fetal outcomes in twin pregnancies following repeat betamethasone administration during pregnancy.

Eligibility criteria: Inclusion Criteria:

* Study group - women who received 2 courses of betamethasone between 24 - 34 weeks' gestation.
* Control comparison group - women who received 1 course of betamethasone between 24 - 34 weeks' gestation.

Exclusion Criteria:

* singletone pregnancies
* higher order multiple pregnancies (triplets and above)
* known major congenital anomaly

Primary outcomes:
measure: The incidence of respiratory morbidity after single versus repeat course of betamethasone for threatened preterm labor between 24-34 weeks' gestation
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Rambam health care campus
Study officials:
affiliation: Rambam Health Care Campus
name: Yaniv Zipori, M.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04182412: Abdominal Rectus Diastasis (ARD) Reconstruction
Official title: Minimally Invasive Abdominal Wall Reconstruction in Symptomatic Rectus Diastasis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Rectus Diastasis
Keywords: Laparoscopy
mesh reinforcement
abdominal stability
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
First posted: 2019-12-02
Enrollment: 110
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: two different laparoscopic to one of techniques for abdominal wall reconstruction: narrowing of linea alba with continuous suture, with and without mesh
Primary purpose: TREATMENT

Brief summary: The aim of this study is to investigate whether abdominal wall reconstruction through laparoscopic surgery can be recommended as a safe treatment alternative for patients with symptomatic rectus diastasis, and if this type of treatment leads to improved quality of life, trunk stability and reduced pain.

Detailed description: Investigate whether surgical reconstruction with laparoscopic technique can lead to improved quality of Life, trunk stability and reduced pain in patients with symptomatic rectus diastasis. The study will also compare two different laparoscopic surgery methods for abdominal wall reconstruction: narrowing of linea alba with continuous suture with or without mesh.

Eligibility criteria: Inclusion Criteria:

* Rectus diastasis ≥3 cm
* BMI =\<28 kg/m2
* non smoker
* abdominal instability,
* abdominal wall and/or lower back pain despite physical therapy / structured physical exercise for at least 6 months

Exclusion Criteria:

* BMI \>28 kg/m2
* Smoking
* Ongoing immunosuppressive therapy
* Current pregnancy ≥16 weeks gestational age for the last 12 months
* Pregnant or women who wish to become pregnant
* Previously extensive abdominal wall surgery incl hernia surgery (NOT including sectio, appendectomy, small umbilical herniae)

Primary outcomes:
measure: Rate of recurrence
timeFrame: 1 year
Secondary outcomes:
measure: Visual Analog Pain Scale (VAS)
timeFrame: 1 year, 3 years
measure: Abdominal stability
timeFrame: 1 year, 3 years
measure: SF-36 Quality of Life instrument
timeFrame: 1 year, 3 years
measure: VHPQ is a questionnaire for the assessment of pre- and postoperative pain
timeFrame: 1 year, 3 years
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Karolinska Institutet, Ersta Hospital
state: Region Stockholm
Study officials:
affiliation: Karolinska Institutet
name: Anders Thorell, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05150912: Mnaual Therapy in Treatment of Carpal Tunnel Syndrome
Official title: Manual Therapy Based on Neurodynamic Techniques Versus Manual Therapy Including Desensitization Maneuvers With One Year Follow-up :Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Carpal Tunnel Syndrome
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2021-12-09
Enrollment: 412
Sex: FEMALE
Minimum age (years): 45
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: 2 groups of patients randomized for the treatment.

Detailed description: One group treated with neurodynamic techniques and the the other with the desensitization maneuvers.

Eligibility criteria: Inclusion Criteria:

* Pain and paresthesia at median nerve distribution ,positive tinel sign and positive phalen sign.

Exclusion Criteria:

* Any sensory and/or motor deficit in either ulnar or radial nerve
* age greater than 55 years .
* male sex.

Primary outcomes:
measure: PAIN and function
timeFrame: after one year
measure: muscle strength
timeFrame: 3 month
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Sahar
Study officials:
References: