Clinical trial NCT07024264: Measured Versus Estimated Energy Requirement in the ICU Patients
Official title: Caloric Estimation Using Predictive Equations and Indirect Calorimetry in ICU Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Critical Illness
Energy Requirement
Equation
Indirect Calorimetry
Malnutrition
Lead sponsor: Taipei Medical University Shuang Ho Hospital
Sponsor class: OTHER
First posted: 2025-06-17
Enrollment: 133
Sex: ALL
Minimum age (years): 20
Maximum age (years): 105
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients admitted to ICU and ventilator dependent in Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare.

Brief summary: The goal of this observational study is to compare energy requirements estimated by predictive equation and indirect calorimetry across different BMI categories, and to examine how these estimates, along with early nutritional strategies and progressive caloric delivery relate to ICU outcomes. The main questions it aims to answer are:

1. To evaluate whether predictive equation and/or indirect calorimetry provides accurate caloric targets in critically ill patients.
2. To identify high-risk malnutrition patients (underweight, normal and overweight, obese) who may benefit most from IC-based measurement.
3. To investigate the impact of caloric strategies and nutritional achievement during the acute phase on the length of ICU stay.


Eligibility criteria: Inclusion Criteria:

* Length of ICU stay \> 4 days
* Mechanically ventilated adults (\>20 y/o)
* Tube feeding
* At high risk of malnutrition by Global Leadership Initiative on Malnutrition (GLIM) criteria: underweight and obesity
* Doctor's preference: cachexia, hypermetabolic status, TPN etc.,...

Exclusion Criteria:

* Length of ICU stay \<4 days
* Mechanically ventilated adults (\<=20 y/o)

Primary outcomes:
measure: The primary outcome was ICU length of stay.
timeFrame: From admitted to ICU which defined as day 1, until transferred to the general wards or expired, up to 12 weeks.
Secondary outcomes:
Other outcomes:
Locations:
city: New Taipei City
country: Taiwan
facility: Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare
Study officials:
References:
citation: McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, McCarthy MS, Davanos E, Rice TW, Cresci GA, Gervasio JM, Sacks GS, Roberts PR, Compher C; Society of Critical Care Medicine; American Society for Parenteral and Enteral Nutrition. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr. 2016 Feb;40(2):159-211. doi: 10.1177/0148607115621863. No abstract available.
citation: Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, Hiesmayr M, Mayer K, Montejo JC, Pichard C, Preiser JC, van Zanten ARH, Oczkowski S, Szczeklik W, Bischoff SC. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019 Feb;38(1):48-79. doi: 10.1016/j.clnu.2018.08.037. Epub 2018 Sep 29.
citation: De Waele E, Jonckheer J, Wischmeyer PE. Indirect calorimetry in critical illness: a new standard of care? Curr Opin Crit Care. 2021 Aug 1;27(4):334-343. doi: 10.1097/MCC.0000000000000844.
citation: Zusman O, Theilla M, Cohen J, Kagan I, Bendavid I, Singer P. Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study. Crit Care. 2016 Nov 10;20(1):367. doi: 10.1186/s13054-016-1538-4.