Clinical trial NCT03529838: Hemodynamic and Salivary Responses of 12 Weeks of Training With Different Anti-hypertensive
Official title: Hemodynamic Responses and Salivary Markers of the Interaction of 12 Weeks of Training With Different Anti-hypertensive in Menopausal Women
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Hypertension
Menopause
Keywords: Combined Exercise
Ambulatorial Blood Pressure Monitoring
Blood analysis
Salivary analysis
Heart rate variability
Lead sponsor: Federal University of Uberlandia
Sponsor class: OTHER
First posted: 2018-05-18
Enrollment: 30
Sex: FEMALE
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 45 women taking different antihypertensives (15 no medications, 15 angiotensin receptor blockers and 15 beta blockers) for at least 6 months will be assessed at baseline and after 12 weeks of combined exercise training.
Primary purpose: PREVENTION

Brief summary: Different classes of antihypertensives may have different responses when associated with exercise. Thus, this study aims to compare the responses of the association of 12 weeks of aerobic exercise and weightlifting with different classes of medications in 45 postmenopausal hypertensive women.

Detailed description: Cardiovascular diseases are the leading causes of death and postmenopausal women. Physical exercise, in turn, is a strategy to reduce cardiovascular stress, by decreasing the blood pressure (BP) at rest and several risk factors associated with sedentary lifestyle, thus improving the quality and life expectancy of these women. However, different classes of antihypertensives may have different responses when associated with exercise. Thus, this study aims to compare the responses of the association of 12 weeks of aerobic exercise and weightlifting with different classes of medications in 45 postmenopausal hypertensive women. The volunteers will do cardiovascular and biochemistry evaluations before and after the intervention.

Eligibility criteria: Inclusion Criteria:

* Women aged between 50 and 70 years;
* Be in the postmenopausal phase;
* Be able to practice physical exercise on treadmill and bodybuilding,
* Receive a release certificate for exercise practice;
* Do not present physical problems or cardiovascular complications that prevent the performance of physical exercises;
* In the case of hypertensives: present stage 1 hypertension, according to the guidelines of the Brazilian Society of Hypertension (2010);
* In the case of hypertensive patients, undergo drug treatment with β-blockers or Angiotensin receptor blockers.

Exclusion Criteria:

* Present history of stroke or acute myocardial infarction;
* Smokers;
* Present diagnosis of Diabetes Mellitus or renal pathologies;
* Use of antihypertensive drugs from classes that were not selected for this project;
* Make use of hormonal therapies;
* Being uncompensated hypertensive.

Primary outcomes:
measure: Changes in Ambulatorial Blood Pressure
timeFrame: Before and within 72 hours after 12 weeks of exercise training
Secondary outcomes:
measure: Changes in Ambulatorial Blood Pressure Variability
timeFrame: Before and within 72 hours after 12 weeks of exercise training
measure: Changes in Heart Rate Variability
timeFrame: Before and within 72 hours after 12 weeks of exercise training
measure: Changes in salivary oxidative stress
timeFrame: Before and within 72 hours after 12 weeks of exercise training
measure: Changes of blood pressure reactivity
timeFrame: Before and within 72 hours after 12 weeks of exercise training
measure: Changes of Biochemical markers on blood
timeFrame: Before and within 72 hours after 12 weeks of exercise training
Other outcomes:
Locations:
city: Uberlandia
country: Brazil
facility: Guilherme Morais Puga
state: Minas Gerais
Study officials:
References:
citation: Mariano IM, Amaral AL, V Carrijo VH, Costa JG, Rodrigues ML, Cunha TM, Puga GM. Different cardiovascular responses to exercise training in hypertensive women receiving beta-blockers or angiotensin receptor blockers: A pilot study. Clin Exp Hypertens. 2022 Jul 4;44(5):442-450. doi: 10.1080/10641963.2022.2065290. Epub 2022 Apr 23.