Clinical trial NCT04042779: Development of a Model-based Working Memory Training and Investigation of Its Comparative Efficacy
Official title: Development of a Model-based Working Memory Training and Investigation of Its Comparative Efficacy: A Randomized, Double-blind Study on Healthy Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Working Memory
Keywords: Multiple task training
Single task training
Model-based working memory training
Cognitive training
Long-term WM capacity
near transfer effects of the training
far transfer effects of the training
Lead sponsor: University Hospital, Basel, Switzerland
Sponsor class: OTHER
First posted: 2019-08-02
Enrollment: 131
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This study is to investigate the efficacy of model-based Working Memory (WM) training using an appropriate control condition. The interventions are a model-based, a single-task and a multiple-task training on WM in order to compare the efficacies of these different training approaches for WM. A sham intervention acts as active control group. Each intervention will be presented on a tablet device.


Eligibility criteria: Inclusion Criteria:

* Informed consent as documented by signature

Exclusion Criteria:

* Medical history of neurological or psychiatric disorders
* Any history of substance abuse
* Color vision deficiency
* Inability to used table devices
* Montreal Cognitive Assessment \< 26

Primary outcomes:
measure: Change in Rotation Span Task Score
timeFrame: assessment at baseline (=T2) and 3 weeks after baseline (=T3)
measure: Change in Symmetry Span Task Score
timeFrame: assessment at baseline (=T2) and 3 weeks after baseline (=T3)
measure: Change in Operation Span Task Score
timeFrame: assessment at baseline (=T2) and 3 weeks after baseline (=T3)
Secondary outcomes:
measure: Change in Rotation Span Task Score
timeFrame: assessment at baseline (=T2) and 12 weeks after baseline (=T4)
measure: Change in Symmetry Span Task Score
timeFrame: assessment at baseline (=T2) and 12 weeks after baseline (=T4)
measure: Change in Operation Span Task Score
timeFrame: assessment at baseline (=T2) and 12 weeks after baseline (=T4)
measure: Change in Trail making Test A/B
timeFrame: assessment at baseline (=T2) and 3 weeks after baseline (=T3) and 12 weeks after baseline (=T4)
measure: Change in Rey Auditory Verbal Learning test
timeFrame: assessment at baseline (=T2) and 3 weeks after baseline (=T3) and 12 weeks after baseline (=T4)
measure: Change in Rey Osterrieth Complex Figure Test
timeFrame: assessment at baseline (=T2) and 3 weeks after baseline (=T3) and 12 weeks after baseline (=T
measure: Change in Raven's Progressive Matrices
timeFrame: assessment at baseline (=T2) and 3 weeks after baseline (=T3) and 12 weeks after baseline (=T
measure: Change in Depression Anxiety Stress Scales
timeFrame: assessment at baseline (=T2) and 3 weeks after baseline (=T3) and 12 weeks after baseline (=T
Other outcomes:
Locations:
city: Basel
country: Switzerland
facility: Department of Neurology, University Hospital Basel
Study officials:
affiliation: Department of Neurology, University Hospital Basel
name: Stefano Magon, Dr. phil.
role: PRINCIPAL_INVESTIGATOR
References: