louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06809868: Role of Transposable Elements in Septic Immune Aging
Official title: Role of Transposable Elements in Septic Immune Aging
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Sepsis
Sepsis and Septic Shock
Sepsis With Multiple Organ Dysfunction (MOD)
Sepsis With Acute Organ Dysfunction
Sepsis, Severe
Sepsis at Intensive Care Unit
Sepsis, Severe Sepsis and Septic Shock
Sepsis, Septic Shock
Keywords: Sepsis
Transposable Elements
Immune Aging
Mortality
Secondary Infections
Critical Care Medicine (ICU)
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2025-02-05
Enrollment: 116
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population includes adult patients admitted to the intensive care unit with sepsis with a SOFA score of at least 2. Sepsis is defined by the Sepsis 3 Criteria.

Brief summary: The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is:

1. Do transposable elements prematurely age the immune systems of patients with sepsis?
2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU?
3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU?

Participants will have blood drawn from them but will not be subjected to additional interventions.


Eligibility criteria: Inclusion Criteria:

* Age 18 or older
* Admitted to ICU with sepsis (Sepsis 3 Criteria)
* SOFA score of at least 2 at time of enrollment

Exclusion Criteria:

* Patients on organ transplantation immunosuppression
* Patients with preexisting leukopenia
* Cancer patients receiving CAR-T therapy
* Patients who are under 18 years of age or otherwise deemed pediatric
* Patients with an ongoing bleeding diathesis (ie: DIC, hemorrhagic shock)
* Patients with a chronic hemoglobin below 7.0
* Patients who, prior to their ICU admission, are blood transfusion dependent

Primary outcomes:
measure: Immune Aging
timeFrame: 6 weeks
Secondary outcomes:
measure: Mortality (30-day)
timeFrame: 30 days
measure: Secondary Infection
timeFrame: 30 days
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: University of California, San Francisco
state: California
Study officials:
affiliation: University of California, San Francisco
name: Alexendar R Perez, M.D., Ph.D
role: PRINCIPAL_INVESTIGATOR
affiliation: University of California, San Francisco
name: Judith Hellman, M.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: University of California, San Francisco
name: Matthieu Legrand, M.D., Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01102868: IMS-treatment and Canalis Carpi Syndrome
Official title: An Randomized Controlled Trial of IMS-treatment Versus Scam for Canalis Carpi Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Carpal Tunnel Syndrome
Lead sponsor: NORCE Norwegian Research Centre AS
Sponsor class: OTHER
First posted: 2010-04-13
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Maximum age (years): 67
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Carpal tunnel syndrome is a condition in which the median nerve is compressed at the wrist, leading to paresthesias, numbness and muscle weakness in the hand. Treatment of the condition often involves surgery.

In this study we wish to se if there is an effect of using intramuscular stimulation (IMS) to release the tension of nervus medianus in the lower arm. The study will be performed by randomization to IMS of musculus pronator teres or a control ("Scam IMS treatment" to the acupuncture point Li11). The two insertion points are approximately 1cm apart in the lower arm.

Detailed description: The most important outcome measure is ultra sound measured diameters for nervus medianus in the carpal tunnel

Eligibility criteria: Inclusion Criteria:

* Canalis Carpi Syndrome verified by ultrasound and clinically
* Both genders
* Age from 18 to 67

Exclusion Criteria:

* Negative neurophysiology result.
* Epilepsy,
* Heart disease,
* Rheumatism
* Unstable angina pectoris,
* Metal -allergy,
* Needle- phobia,
* Infection
* Hemophilia
* Cognitive problems

Primary outcomes:
measure: Diameter of the Nervae medianus in the Carpal Tunnel
timeFrame: End 2011
Secondary outcomes:
measure: Health complaints
timeFrame: End 2011
measure: Power of the hand grip
timeFrame: End 2011
Other outcomes:
Locations:
city: Bergen
country: Norway
facility: Uni Health, Uni Research
Study officials:
affiliation: Uni Health, University Research
name: Stein Atle Lie, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kvist KB, Hilland R, Enehaug R, Schjelderup J, Lie SA, Halse AK. The treatment effect of intramuscular stimulation on carpal tunnel syndrome: A blinded randomized trial on 75 patients. J Bodyw Mov Ther. 2021 Jul;27:522-528. doi: 10.1016/j.jbmt.2021.03.020. Epub 2021 Apr 20.
Clinical trial NCT01885468: X-Ray Verified Accuracy of the proGAV Verification Instrument
Official title: X-Ray Verified Accuracy of the Aesculap - Miethke proGAV Adjustable Shunt Pressure Setting Verification Instrument
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hydrocephalus Shunt (proGAV) Requiring Adjustment
Keywords: Hydrocephalus shunt
proGAV
Lead sponsor: Aesculap, Inc.
Sponsor class: INDUSTRY
First posted: 2013-06-25
Enrollment: 12
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Hydrocephalus patients implanted with proGAV shunt requiring adjustment

Brief summary: This study is to verify the use of a hand held tool to verify the new setting of a hydrocephalus shunt (proGAV). This tool would be used in place of an Xray of the patient's head, which is how settings are verified currently.


Eligibility criteria: Inclusion Criteria:

* Implanted with proGAV Requiring adjustment Implant must be palpable under the skin

Exclusion Criteria:

* Unwilling to consent Implanted within 7 days of inclusion visit

Primary outcomes:
measure: Level of agreement between the proGAV® verification instrument measurement and X-ray control measurements.
timeFrame: 1day
Secondary outcomes:
Other outcomes:
Locations:
city: Madeira
country: United States
facility: Valley Children's Hospital
state: California
city: Danville
country: United States
facility: Geisinger Medical Center
state: Pennsylvania
Study officials:
References:
Clinical trial NCT00913068: Postoperative Pain Control for Prostatectomy
Official title: Post Operative Analgesia Using the Transverse Abdominal Plan (TAP) Block in Patients Undergoing a Radical Retropubic Prostatectomy (RRP)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prostate Cancer
Keywords: radical prostatectomy
Lead sponsor: Nova Scotia Health Authority
Sponsor class: OTHER
First posted: 2009-06-03
Enrollment: 110
Sex: MALE
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The researchers propose to investigate a relatively new anesthetic procedure, in order to maximize patient comfort and minimize the use of narcotics after a radical prostatectomy.

Detailed description: Our current post operative analgesic strategy involves a multi-modal approach, using local injectable anesthetic around the incision and systemic medications (i.e. non-steroidal anti-inflammatories, acetaminophen and break-through doses of opiates). As the amount of opiates used can be significant, we have to be aware of their inherent risks. Opiates have an excellent pain control profile, working peripherally by decreasing the amount of neurotransmitters released from neurons involving noxious stimuli, and also in their central processing. Some of the more common adverse reactions are reparatory depression, sedation, confusion, delirium, nausea, pruritis, constipation, hypotension and bradycardia. Often it is these resulting side effects that extend the length of in hospital rehabilitation, and decrease a patient's overall satisfaction.

Thus we propose the use of a relatively new regional anesthetic technique be employed to further decrease the need for opiates in our prostatectomy patients' post-op course, while adequately controlling their pain.

Eligibility criteria: Inclusion Criteria:

* prostate cancer for radical prostatectomy

Exclusion Criteria:

* chronic pain or opiate use

Primary outcomes:
measure: Total Milligrams of Opiates
timeFrame: 2, 6,12, 24, 48 and 72 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Halifax
country: Canada
facility: Queen Elizabeth Health Sciences Centre
state: Nova Scotia
Study officials:
affiliation: Queen Elizabeth Health Sciences Centre
name: Ricardo A Rendon, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04831268: Effects of Traditional Greek Meals on Glycemic Responses
Official title: Effects of Traditional Greek Meals: Lentils With Lupino, Trahanas With Tomato Sauce and Halva With Currants on Glycemic Responses: Randomized Clinical Trial in Healthy Humans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Potential Abnormality of Glucose Tolerance
Appetitive Behavior
Keywords: blood glucose
lentils
trahanas
halva
glycemic index
Lead sponsor: Agricultural University of Athens
Sponsor class: OTHER
First posted: 2021-04-05
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Crossover Assignment
Primary purpose: OTHER

Brief summary: This study investigated the effects of Greek traditional meals in dehydrated form consumed after reconstitution with water on glycemic responses

Detailed description: This study aimed at 1. to determined the glycemic index and glycemic load of three mixed meals and 2. to investigate the effects of these mixed meals on postprandial glycemic response in healthy subjects

Eligibility criteria: Inclusion Criteria:

* healthy
* non-smoking
* non-diabetic men and women
* normal body mass index (BMI; between 18.5 and 25 kg/m2)

Exclusion Criteria:

* severe chronic disease (e.g. coronary heart disease, diabetes mellitus, kidney or liver conditions, endocrine conditions)
* gastrointestinal disorders
* pregnancy
* lactation
* competitive sports
* alcohol
* drug dependency

Primary outcomes:
measure: Capillary blood glucose responses
timeFrame: 2 hours
Secondary outcomes:
measure: Subjective appetite ratings
timeFrame: 2 hours
measure: Blood pressure
timeFrame: 2 hours
Other outcomes:
Locations:
city: Athens
country: Greece
facility: Agricultural University of Athens
state: Attica
Study officials:
affiliation: Agricultural University of Athens
name: Aimilia Papakonstantinou, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01462968: Interruptions in the Coagulationsystem in Relation With Cardiac Surgery - A Study Comparing Two Heparinization Strategies During On-pump Cardiac Surgery
Official title: Interruptions in the Coagulationsystem in Relation With Cardiac Surgery -A Randomized Study Comparing Two Heparinization Strategies During On-pump Cardiac Surgery
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Cardiac Surgery
Keywords: Heparin treatment during cardiac surgery
Heparin reversal after cardiac surgery
Thrombin generation
Endogenous Thrombin potential
Lead sponsor: Aalborg University Hospital
Sponsor class: OTHER
Collaborators: name: Medtronic
First posted: 2011-11-01
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to find the heparinization method, which

1. affect the heparin-protaminsulfate ratio in the best way to achieve haemostasis
2. gives the smallest change in endogenous thrombin potential (ETP)postoperative compared to preoperative (deltaETP) as an indicator for haemostatic activation during cardiac surgery.

The hypothesis is that the deltaETP is larger in the Haemochron Signature Elite group than in the Hepcon-group because of the heparinization-method. Therefore there is a potential higher risk for use of bloodproducts postoperatively.


Eligibility criteria: Inclusion Criteria:

* Elective on-pump coronary artery bypass grafting (CABG) single procedure
* Elective aortavalve replacement (AVR) (single procedure)

Exclusion Criteria:

* Emergency procedures
* Children and youngsters less than 18 years
* Pregnancy
* Less than 2 days break with platelet inhibiting drugs (acetylsalicylic acid, NSAID, clopidogrel, serotonin reuptake inhibitors)
* Less than 2 days break with AC-treatment (warfarin, heparin, coumarin etc)
* Known coagulopathy
* Endocarditis
* Preoperative anaemia
* Dialysis patients

Primary outcomes:
measure: Delta Thrombingeneration
timeFrame: Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours.
Secondary outcomes:
measure: peroperative heparine/protaminesulphate ratio
timeFrame: The timeframe is from the first heparin is given to the neutralization with protamine sulfate, average time 4 hours
measure: Platelet function
timeFrame: Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours.
measure: Thromboelastometry
timeFrame: Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours.
measure: Standard coagulationtests
timeFrame: Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours.
Other outcomes:
Locations:
city: Aalborg
country: Denmark
facility: Aalborg Hospital
Study officials:
affiliation: Heart-Lung surgery unit, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, DK-9000 Aalborg
name: Susanne de Neergaard, Perfusionist
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04406168: Assessment of Urinary Diversions Outcomes Post Radical Cystectomy in Asyut University Urology Hospital
Official title: Assessment of Urinary Diversions Outcomes Post Radical Cystectomy in Asyut University Urology Hospital
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Bladder Cancer
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-05-28
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All cases that fulfil the selection criteria that have been admitted in Asyut university urology hospital (non probability sample size) with expected size of 40 patients starting from 01/01/2013 to1/05/2020.

Additionally, the competence of follow-up will be approved by imaging and medical records.

Brief summary: Radical cystectomy (RC) for bladder cancer requires reconstruction of the lower urinary tract. Both continent and incontinent diversions are available for urinary reconstruction after RC. Types of urinary diversions include ( ileal conduit, uretero-cutaneous, ureterosigmoidostomy and orthotopic bladder) The decision process is complex and involves consideration of issues related to cancer stage, patient comorbidities, treatment needs, and patient desires related to Quality of life and intraoperative findings. Outcomes of urinary diversions include 1- survival rate (cancer specific or overall survival). 2- Oncological failure (local, distant or LNs). 3- Complications (perioperative, intraoperative or post-operative).

In this study, all these outcomes will be analyzed.


Eligibility criteria: Inclusion Criteria:

* \* All patients underwent radical cystectomy more than 1 year

Exclusion Criteria:

* incomplete data
* patients underwent RC outside urology department and presented for treatment of complications.

Primary outcomes:
measure: Rate of patients presented by complications
timeFrame: 1 year post operative
measure: Rate of patients developed recurrence
timeFrame: 1 year post operative
measure: Survival rate (overall survival & cancer specific)
timeFrame: 1 year post operative
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University
state: Elgam3a
Study officials:
affiliation: prof
name: salah s abdelhafez
role: STUDY_DIRECTOR
References:
Clinical trial NCT02177968: Public Health Concerns of Elderly Fallers and Non-fallers in a Community
Official title: Public Health Concerns of Elderly Fallers and Non-fallers in a Southeastern Community of Brazil
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Accidental Falls
Aging
Keywords: fall
elderly
characteristics
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2014-06-30
Enrollment: 100
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community sample

Brief summary: The purpose of this study is to identify the prevalence and the characterization of health of elderly fallers and non-fallers in the southeastern community of Brazil in the state of São Paulo.

Detailed description: The population consisted of 638 elderly individuals enrolled and attended by the teams of the Family Health Strategy in the city of Araraquara, São Paulo state. The sample was selected in a systematic way, considering the order of micro-areas, 1-7, which 10% sampling error, 15% rate answer. To this, instruments were used based SABE Study, Health Wellbeing and Aging modified, and the International Physical Activity Questionnaire (IPAQ), short version.

Eligibility criteria: Inclusion Criteria:

* People aged 60 years and over

Exclusion Criteria:

* Vestibular alteration
* Postoperative requiring continuous home
* Low vision or complete blind
* Bedridden
* Empty house
* Subjects without registration at the health family unity

Primary outcomes:
measure: Healthy, Well-being and Aging questionnaire
timeFrame: 5 months
Secondary outcomes:
Other outcomes:
Locations:
city: Araraquara
country: Brazil
facility: Educação Permanente, Prefeitura Municipal de Araraquara
state: Sao Paulo
Study officials:
name: Luciana PZ Traldi, research
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01078168: Alzheimer's Disease Acitretin Medication
Official title: Changes of Cerebral Spinal Fluid APPSα Levels Under Oral Therapy With Acitretin 30 mg Daily in Patients With Mild to Moderate Alzheimer's Disease: a Multicenter Prospective Randomised Placebo-controlled Parallel-group Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Alzheimer Disease
Keywords: Alzheimer's Disease
Lead sponsor: Johannes Gutenberg University Mainz
Sponsor class: OTHER
Collaborators: name: Alzheimer Forschungsinitiative e.V. (AFI)
First posted: 2010-03-02
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The trials investigates the changes of cerebral spinal fluid (CSF) soluble alpha-secretase cleaved APP (APPsα) levels under oral therapy with acitretin 30mg daily in patients with mild to moderate Alzheimer's disease (AD).The present study aims to demonstrate an enhancement of the α-secretase activity by acitretin as measured by increased CSF APPSα levels in human AD. Second, the safety and tolerability of acitretin in AD patients should be proven.


Eligibility criteria: Inclusion Criteria:

* mild to moderate AD (NINCDS-ADRDA criteria)
* Mini-Mental State Examination (MMSE): 27-14 points
* Geriatric Depression Scale ≤ 14

Exclusion Criteria:

* hereditary cognitive impairment
* known history of brain injuries
* Insufficient German language skills
* actual treatment with other potential disease modifying drugs of AD
* multimorbidity or significant organ (esp. liver or renal) dysfunction
* evidence of Non-AD neurodegenerative disorder (e.g. Parkinson)
* contraindication to acitretin such as osteoporosis, hypoalbuminaemia

Primary outcomes:
measure: Difference in Cerebrospinal Fluid (CSF) Soluble Alpha-clevaed Amyloid Precursor Protein (APPsα) Concentration at Visit 3 Compared to Baseline
timeFrame: baseline and 4 weeks (visit 3)
Secondary outcomes:
Other outcomes:
Locations:
city: Mainz
country: Germany
facility: Department of psychiatry and psychotherapy, University medical center of the Johannes Gutenberg-University Mainz
state: Rheinland-Pfalz
city: Rostock
country: Germany
facility: Universität Rostock
Study officials:
affiliation: Department of psychiatry and psychotherapy, University medical center of the Johannes Gutenberg-University Mainz, Germany
name: Andreas Fellgiebel, PD Dr.
role: PRINCIPAL_INVESTIGATOR
References: