Clinical trial NCT06073821: Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)
Official title: A Phase 3, Open-Label, Randomized Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Patients With Previously Untreated Chronic Lymphocytic Leukemia
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: CLL
Keywords: CLL
Chronic Lymphocytic Leukemia
Lead sponsor: BeiGene
Sponsor class: INDUSTRY
First posted: 2023-10-10
Enrollment: 652
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The main objective of this study is to compare the efficacy of sonrotoclax plus zanubrutinib versus venetoclax plus obinutuzumab in participants with chronic lymphocytic leukemia (CLL)

Detailed description: Chronic lymphocytic leukemia is a type of blood cancer that affects people around the world. People with CLL suffer from enlarged lymph nodes, spleen, or liver, or have symptoms like night sweats, weight loss and fever. They have shorter life expectancy compared to healthy people. There is an urgent need for new treatment to prolong life and control disease-related symptoms.

In this study, participants with CLL without prior treatment will receive either venetoclax plus obinutuzumab combination treatment that is considered a standard first line treatment or receive sonrotoclax plus zanubrutinib. It is hypothesized that sonrotoclax plus zanubrutinib may be better than venetoclax plus obinutuzumab in treating CLL.

The main purpose of this study is to compare the duration the participants live without the CLL getting worse between participants who received sonrotoclax plus zanubrutinib versus venetoclax plus obinutuzumab. Approximately 652 participants will be included in this study around the world. Participants will have equal chance to be allocated to receive either of the treatment combinations.

Eligibility criteria: Inclusion Criteria:

* Treatment-naïve (TN) adults with confirmed diagnosis of CLL which requires treatment
* Eastern Cooperative Oncology Group (ECOG) score 0, 1, or 2
* Measurable disease by Computer Tomography/Magnetic Resonance Imaging
* Adequate liver function as indicated by aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x the institutional upper limits of normal (ULNs) value; serum total bilirubin \< 3.0 x ULN
* Adequate renal function as defined as creatinine clearance ≥ 50 milliliters per minute

Exclusion Criteria:

* Previous systemic treatment for CLL
* Known prolymphocytic leukemia or history of, or currently suspected, Richter's transformation
* Known central nervous system involvement
* History of confirmed progressive multifocal leukoencephalopathy (PML)
* Uncontrolled hypertension

Note: Other protocol defined criteria may apply

Primary outcomes:
measure: Cohort 1: Progression Free Survival (PFS）
timeFrame: Up to approximately 9 years
measure: Cohort 1: Rate of Undetectable Measurable Residual Disease
timeFrame: Up to one and a half years
Secondary outcomes:
measure: Cohort 1: Complete Response Rate (CRR ) by IRC
timeFrame: Up to approximately 9 years
measure: Cohort 1: Overall Survival (OS)
timeFrame: Up to approximately 9 years
measure: Cohort 1: PFS by Investigator Assessment
timeFrame: Up to approximately 9 years
measure: Cohort 1: CRR by Investigator Assessment
timeFrame: Up to approximately 9 years
measure: Cohort 1: Rate of Undetectable Measurable Residual Disease
timeFrame: Up to approximately 9 years
measure: Cohort 1: Overall Response Rate (ORR) by IRC and Investigator Assessment
timeFrame: Up to approximately 9 years
measure: Cohort 1: Duration of Response (DOR) by IRC and Investigator Assessment
timeFrame: Up to approximately 9 years
measure: Pooled Cohorts: PFS by IRC and Investigator Assessment
timeFrame: Up to approximately 9 years
measure: Pooled Cohorts: ORR by IRC and Investigator Assessment
timeFrame: Up to approximately 9 years
measure: Pooled Cohorts: DOR by IRC and Investigator Assessment
timeFrame: Up to approximately 9 years
measure: Pooled Cohorts: Rate of Undetectable Measurable Residual Disease
timeFrame: Up to approximately 9 years
measure: Pooled Cohorts: CRR by IRC and Investigator Assessment
timeFrame: Up to approximately 9 years
measure: Cohort 1 and Pooled Cohorts: Number of Participants with Adverse Events (AEs) and Serious Adverse Events (SAEs)
timeFrame: Up to one and a half years for Sonrotoclax Plus Zanubrutinib group and 13 months for Venetoclax Plus Obinutuzumab group]
measure: Cohort 1 and Pooled Cohorts: Change from baseline in European Organization for Research and Treatment of Cancer Quality of Life Cancer Questionnaire -Core 30 (EORTC QLQ-C30) Global Health Status/QoL (GHS) and Physical Functioning Scales
timeFrame: Every three cycles during the treatment period
measure: Cohort 1 and Pooled Cohorts: Change from baseline in EORTC Quality of Life Questionnaire - Chronic Lymphocytic Leukemia Module 17 Items (QLQ-CLL17) Symptom Burden and Physical Condition Scales
timeFrame: Every three cycles during the treatment period
measure: Cohort 1 and Pooled Cohorts: Change from baseline in European Quality of Life 5-Dimensions 5-Levels Health Questionnaire （EQ-5D-5L) Visual Analogue Scale (VAS).
timeFrame: Every three cycles during the treatment period
Other outcomes:
Locations:
city: Anchorage
country: United States
facility: Alaska Oncology and Hematology, Llc
state: Alaska
city: Duarte
country: United States
facility: City of Hope National Medical Center
state: California
city: La Jolla
country: United States
facility: University of California San Diego (Ucsd) Moores Cancer Center
state: California
city: Los Angeles
country: United States
facility: Valkyrie Clinical Trials
state: California
city: Los Angeles
country: United States
facility: UCLA Department of Medicine Hematologyoncology
state: California
city: Orange
country: United States
facility: Chao Family Comprehensive Cancer Center
state: California
city: Palo Alto
country: United States
facility: Stanford Medicine
state: California
city: Aurora
country: United States
facility: University of Colorado Cancer Center
state: Colorado
city: New Haven
country: United States
facility: Yale University, Yale Cancer Center
state: Connecticut
city: Washington
country: United States
facility: Medstar Georgetown University Hospital
state: District of Columbia
city: Miami Beach
country: United States
facility: Mount Sinai Comprehensive Cancer Center
state: Florida
city: Tampa
country: United States
facility: Moffitt Cancer Center
state: Florida
city: Newnan
country: United States
facility: Southeastern Regional Medical Center
state: Georgia
city: Chicago
country: United States
facility: Northwestern University
state: Illinois
city: Peoria
country: United States
facility: Illinois Cancercare, Pc
state: Illinois
city: Fort Wayne
country: United States
facility: Fort Wayne Medical Oncology and Hematology
state: Indiana
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics
state: Iowa
city: Waukee
country: United States
facility: Mission Cancer and Blood
state: Iowa
city: Westwood
country: United States
facility: The University of Kansas Cancer Center
state: Kansas
city: Louisville
country: United States
facility: Norton Cancer Institute Pavilion
state: Kentucky
city: New Orleans
country: United States
facility: Ochsner Clinic Foundation
state: Louisiana
city: Minneapolis
country: United States
facility: University of Minnesota
state: Minnesota
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
city: Hackensack
country: United States
facility: John Theurer Cancer Center Hackensack University Medical Center
state: New Jersey
city: New Brunswick
country: United States
facility: Rutgers Cancer Institute of New Jersey
state: New Jersey
city: New York
country: United States
facility: Laura and Isaac Perlmutter Cancer Center At Nyu Langone Health
state: New York
city: New York
country: United States
facility: Columbia University Medical Center
state: New York
city: Westbury
country: United States
facility: Clinical Research Alliance, Inc
state: New York
city: Chapel Hill
country: United States
facility: University of North Carolina At Chapel Hill
state: North Carolina
city: Charlotte
country: United States
facility: Atrium Health Levine Cancer Institute (Lci)
state: North Carolina
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
city: Columbus
country: United States
facility: The James Cancer Hospital and Solove Research Institute At Ohio State University
state: Ohio
city: Eugene
country: United States
facility: Oncology Associates of Oregon Willamette Valley Cancer Center
state: Oregon
city: Philadelphia
country: United States
facility: Fox Chase Cancer Center
state: Pennsylvania
city: Chattanooga
country: United States
facility: Scri Tennessee Oncology Chattanooga
state: Tennessee
city: Salt Lake City
country: United States
facility: Huntsman Cancer Institute
state: Utah
city: Richmond
country: United States
facility: Virginia Cancer Institute
state: Virginia
city: Richmond
country: United States
facility: Vcu Health Systemmassey Comprehensive Cancer Center
state: Virginia
city: Seattle
country: United States
facility: Fred Hutchinson Cancer Research Center
state: Washington
city: La Crosse
country: United States
facility: Gunderson Health System
state: Wisconsin
city: Milwaukee
country: United States
facility: Medical College of Wisconsin
state: Wisconsin
city: Concord
country: Australia
facility: Concord Repatriation General Hospital
state: New South Wales
city: St Leonards
country: Australia
facility: Genesiscare North Shore
state: New South Wales
city: Benowa
country: Australia
facility: Pindara Private Hospital
state: Queensland
city: Birtinya
country: Australia
facility: Sunshine Coast Hospital and Health Service
state: Queensland
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital
state: Queensland
city: Bedford PK
country: Australia
facility: Flinders Medical Centre
state: South Australia
city: Clayton
country: Australia
facility: Monash Health
state: Victoria
city: Fitzroy
country: Australia
facility: St Vincents Hospital Melbourne
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Health
state: Victoria
city: Malvern East
country: Australia
facility: Cabrini Hospital Malvern
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Nedlands
country: Australia
facility: Hollywood Private Hospital
state: Western Australia
city: Innsbruck
country: Austria
facility: Medizinische Universitatsklinik Innsbruck
city: Salzburg
country: Austria
facility: Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg
city: Wien
country: Austria
facility: Hanusch Krankenhaus
city: Botucatu
country: Brazil
facility: Unesp Faculdade de Medicina Da Universidade Estadual Paulista Campus Botucatu
city: Curitiba
country: Brazil
facility: Hospital Erasto Gaertner
city: Porto Alegre
country: Brazil
facility: Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
city: Ribeirao Preto
country: Brazil
facility: Hospital Das Clinicas Da Faculdade de Medicina de Ribeirao Preto Usp
city: Sao Paulo
country: Brazil
facility: Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular
city: Sao Paulo
country: Brazil
facility: Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
city: Edmonton
country: Canada
facility: Cross Cancer Institute
state: Alberta
city: Vancouver
country: Canada
facility: British Columbia Cancer Agency the Vancouver Centre
state: British Columbia
city: Winnipeg
country: Canada
facility: Cancercare Manitoba
state: Manitoba
city: Oshawa
country: Canada
facility: Lakeridge Health
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Cancer Centre
state: Ontario
city: Greenfield Park
country: Canada
facility: Centre Integre de Sante Et de Services Sociaux de La Monteregie Centre
state: Quebec
city: Montreal
country: Canada
facility: Centre Hospitalier de Luniversite de Montreal (Chum)
state: Quebec
city: SaintJerome
country: Canada
facility: Unite de Recherche Clinique Du Cisss Des Laurentides
state: Quebec
city: Sherbrooke
country: Canada
facility: Ciusss de Lestrie Chus
state: Quebec
city: Regine
country: Canada
facility: Allan Blair Cancer Centre, Saskatchewan Cancer Agency
state: Saskatchewan
city: Saskatoon
country: Canada
facility: Saskatoon Cancer Centre
state: Saskatchewan
city: Calgary
country: Canada
facility: Arthur Je Child Comprehensive Cancer Centre
city: Quebec
country: Canada
facility: Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)
city: Hefei
country: China
facility: The First Affiliated Hospital of Anhui Medical University
state: Anhui
city: Beijing
country: China
facility: Peking University Third Hospital
state: Beijing
city: Chongqing
country: China
facility: Chongqing University Cancer Hospital
state: Chongqing
city: Fuzhou
country: China
facility: Fujian Medical University Union Hospital
state: Fujian
city: Guangzhou
country: China
facility: Nanfang Hospital of Southern Medical University
state: Guangdong
city: Jieyang
country: China
facility: Jieyang Peoples Hospital (Jieyang Affiliated Hospital, Sun Yat Sen University )
state: Guangdong
city: Nanning
country: China
facility: The First Affiliated Hospital of Guangxi Medical University
state: Guangxi
city: Nanyang
country: China
facility: Nanyang Central Hospital
state: Henan
city: Zhengzhou
country: China
facility: Henan Cancer Hospital
state: Henan
city: Wuhan
country: China
facility: Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
state: Hubei
city: Yichang
country: China
facility: Yichang Central Peoples Hospitaljiangnan Branch
state: Hubei
city: Changzhou
country: China
facility: The First Peoples Hospital of Changzhou
state: Jiangsu
city: Nanjing
country: China
facility: Jiangsu Province Hospital
state: Jiangsu
city: Nantong
country: China
facility: Affiliated Hospital of Nantong University
state: Jiangsu
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical University
state: Jiangsu
city: Nanchang
country: China
facility: The Second Affiliated Hospital of Nanchang University
state: Jiangxi
city: Shenyang
country: China
facility: The First Hospital of China Medical University
state: Liaoning
city: Xian
country: China
facility: The Second Affiliated Hospital of Xian Jiaotong University
state: Shaanxi
city: Jinan
country: China
facility: Shandong Provincial Hospital
state: Shandong
city: Jining
country: China
facility: Jining No Peoples Hospital West Branch
state: Shandong
city: Yantai
country: China
facility: Yantai Yuhuangding Hospital
state: Shandong
city: Chengdu
country: China
facility: West China Hospital, Sichuan University
state: Sichuan
city: Chengdu
country: China
facility: Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital
state: Sichuan
city: Tianjin
country: China
facility: Institute of Hematology and Hospital of Blood Disease
state: Tianjin
city: Hangzhou
country: China
facility: The First Affiliated Hospital, Zhejiang University School of Medicine
state: Zhejiang
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University
state: Zhejiang
city: Brno
country: Czechia
facility: Fakultni Nemocnice Brno
city: Hradec Kralove
country: Czechia
facility: Fakultni Nemocnice Hradec Kralove
city: Olomouc
country: Czechia
facility: Fakultni Nemocnice Olomouc
city: Ostrava
country: Czechia
facility: Fakultni Nemocnice Ostrava
city: Plze
country: Czechia
facility: Fakultni Nemocnice Plzen
city: Praha
country: Czechia
facility: Vseobecna Fakultni Nemocnice V Praze
city: Bordeaux
country: France
facility: Centre de Lutte Contre Le Cancer Institut Bergonie
city: Clermontferrand
country: France
facility: Chu Clermont Ferrand Therapie Cellulaire and Hematolo
city: Esseylesnancy
country: France
facility: Clinique Louis Pasteur
city: Le Mans
country: France
facility: Centre Hospitalier Le Mans
city: Lille
country: France
facility: Chu Lille
city: Lyon Cedex
country: France
facility: Centre Leon Berard
city: Nantes
country: France
facility: Centre Hospitalier Universitaire Nantes Hotel Dieu
city: Nantes
country: France
facility: Hopital Prive Du Confluent
city: Paris
country: France
facility: Hopital de La Pitie Salpetriere
city: Rennes Cedes
country: France
facility: Chu Rennes
city: Rouen Cedex
country: France
facility: Centre Henri Becquerel
city: Tours
country: France
facility: Chu Tours Hopital Bretonneau
city: VandoeuvrelesNancy
country: France
facility: Chu Nancy Hopital Brabois
city: Berlin
country: Germany
facility: Praxis Am Volkspark
city: Frankfurt am Main
country: Germany
facility: Centrum Fur Haematologie Und Onkologie Bethanien
city: Luebeck
country: Germany
facility: Universitaetsklinikum Schleswig Holstein Campus Luebeck
city: Ashdod
country: Israel
facility: Assuta Ashdod Medical Center
city: Haifa
country: Israel
facility: Carmel Medical Center
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
city: Jerusalem
country: Israel
facility: Hadassah University Hospital Ein Kerem
city: Tel Aviv Jaffa
country: Israel
facility: Assuta Medical Center
city: Bologna
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Santorsola Malpighi
city: Ferrara
country: Italy
facility: Azienda Ospedaliero Universitaria Di Ferrara
city: Milano
country: Italy
facility: Istituto Europeo Di Oncologia
city: Milano
country: Italy
facility: Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
city: Novara
country: Italy
facility: Aou Maggiore Della Carita
city: Padova
country: Italy
facility: Azienda Ospedaliera Di Padova
city: Perugia
country: Italy
facility: Ospedale Santa Maria Della Misericordia
city: Nagoya
country: Japan
facility: Aichi Cancer Center Hospital Clinical Oncology
state: Aichi
city: Chibashi
country: Japan
facility: Chiba Cancer Center
state: Chiba
city: Kashiwa
country: Japan
facility: National Cancer Center Hospital East
state: Chiba
city: MatsuyamaShi
country: Japan
facility: Nho Shikoku Cancer Center
state: Ehime
city: SapporoShi
country: Japan
facility: National Hospital Organization Hokkaido Cancer Center
state: Hokkaido
city: SapporoShi
country: Japan
facility: Aiiku Hospital
state: Hokkaido
city: AmagasakiCity
country: Japan
facility: Hyogo Prefectural Amagasaki General Medical Center
state: Hyogo
city: Kagoshimashi
country: Japan
facility: Kagoshima University Hospital
state: Kagoshima
city: Iseharashi
country: Japan
facility: Tokai University Hospital
state: Kanagawa
city: Sendaishi
country: Japan
facility: Tohoku University Hospital
state: Miyagi
city: Niigatashi
country: Japan
facility: Niigata University Medical and Dental Hospital
state: Niigata
city: Kurashikishi
country: Japan
facility: Kurashiki Central Hospital
state: Okayama
city: Hirakata
country: Japan
facility: Kansai Medical University Hospital
state: Osaka
city: Osakasayama
country: Japan
facility: Kindai University Hospital
state: Osaka
city: ChuoKu
country: Japan
facility: National Cancer Center Hospital
state: Tokyo
city: Yamagatashi
country: Japan
facility: Yamagata University Hospital
state: Yamagata
city: Aomori
country: Japan
facility: Aomori Prefectural Central Hospital
city: Kumamoto
country: Japan
facility: Kumamoto University Hospital
city: Okayama
country: Japan
facility: National Hospital Organization Okayama Medical Center
city: Osaka
country: Japan
facility: Osaka Metropolitan University Hospital
city: YokohamaShi
country: Japan
facility: Yokohama Municipal Citizens Hospital
city: BundangGu SeongnamSi
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
city: IlsandongGu GoyangSi
country: Korea, Republic of
facility: National Cancer Center (Korea)
state: Gyeonggi-do
city: SeochoGu
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St Marys Hospital
state: Seoul Teugbyeolsi
city: SeodaemunGu
country: Korea, Republic of
facility: Severance Hospital Yonsei University Health System
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Seoul Teugbyeolsi
city: SongpaGu
country: Korea, Republic of
facility: Asan Medical Center
state: Seoul Teugbyeolsi
city: Alkmaar
country: Netherlands
facility: Noordwest Ziekenhuisgroep
city: Almere
country: Netherlands
facility: Flevoziekenhuis
city: Amersfoort
country: Netherlands
facility: Meander Medisch Centrum
city: Amsterdam
country: Netherlands
facility: Amsterdam Umc Vu Mc
city: Delft
country: Netherlands
facility: Reinier de Graaf Gasthuis
city: Dordrecht
country: Netherlands
facility: Albert Schweitzer Ziekenhuis
city: Groningen
country: Netherlands
facility: Martini Ziekenhuis
city: Rotterdam
country: Netherlands
facility: Maasstad Hospital
city: Rotterdam
country: Netherlands
facility: Ikazia Ziekenhuis
city: Schiedam
country: Netherlands
facility: Franciscus Gasthuis and Vlietland
city: Sgravenhage
country: Netherlands
facility: Hagaziekenhuis
city: Tilburg
country: Netherlands
facility: Elisabeth Tweesteden Ziekenhuis
city: Auckland
country: New Zealand
facility: North Shore Hospital
city: Auckland
country: New Zealand
facility: Auckland City Hospital
city: Christchurch
country: New Zealand
facility: Health New Zealand Canterbury
city: Dunedin
country: New Zealand
facility: Dunedin Hospital
city: Tauranga
country: New Zealand
facility: Tauranga Hospital
city: Wellington
country: New Zealand
facility: Wellington Regional Hospital (Ccdhb)
city: Lublin
country: Poland
facility: Uniwersytecki Szpital Kliniczny Nr W Lublinie
city: OD
country: Poland
facility: Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi
city: Poznan
country: Poland
facility: Uniwersytecki Szpital Kliniczny
city: Warszawa
country: Poland
facility: Centralny Szpital Kliniczny Uck Wum
city: Warszawa
country: Poland
facility: Instytut Hematologii I Transfuzjologii
city: Wrocaw
country: Poland
facility: Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu
city: San Juan
country: Puerto Rico
facility: Auxilio Mutuo Cancer Center
city: Burgos
country: Spain
facility: Hospital Universitario de Burgos
city: Hospitalet de LLobregat
country: Spain
facility: Institut Catala Doncologia Hospital Duran I Reynals
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Universitario de Gran Canaria Dr Negrin
city: Madrid
country: Spain
facility: Md Anderson Cancer Center Madrid Spain
city: Madrid
country: Spain
facility: Hospital Universitario de Octubre
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Madrid
country: Spain
facility: Hospital Universitario Ramon Y Cajal
city: Tenerife
country: Spain
facility: Hospital La Candelaria
city: Stockholm
country: Sweden
facility: Karolinska Universitetssjukhuset Solna
city: Ankara
country: Turkey
facility: Ankara University Medical Faculty
city: Ankara
country: Turkey
facility: Gazi University
city: Kayseri
country: Turkey
facility: Erciyes University School of Medicine
city: Kocaeli
country: Turkey
facility: Kocaeli Universitesi Tip Fakultesi
city: Bournemouth
country: United Kingdom
facility: University Hospitals Dorset Royal Bournemouth Hospital
city: Canterbury
country: United Kingdom
facility: Kent and Canterbury Hospital
city: Headington
country: United Kingdom
facility: Churchill Hospital Oxford University Hospital Nhs Trust
city: Leeds
country: United Kingdom
facility: St Jamess University Hospital
city: Liverpool
country: United Kingdom
facility: The Clatterbridge Cancer Centre Liverpool
city: London
country: United Kingdom
facility: University College Hospital
city: London
country: United Kingdom
facility: Kings College
city: Norwich
country: United Kingdom
facility: Norfolk and Norwich University Hospitals Nhs Foundation Trust
city: Southampton
country: United Kingdom
facility: Southampton General Hospital
city: Sutton
country: United Kingdom
facility: Royal Marsden Nhs Foundation Royal Marsden Hospital
Study officials:
References: