Clinical trial NCT02747212: Measuring the Electrical Properties of Malignant Tissues Ex Vivo
Official title: Measuring the Electrical Properties of the Excised Malignant Tissues Obtained From Cancer Surgeries
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Neoplasms
Keywords: electrical properties
malignant tissues
ex vivo
Lead sponsor: Southern Medical University, China
Sponsor class: OTHER
Collaborators: name: Zhujiang Hospital
First posted: 2016-04-21
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The patients who are diagnosed with cancer disease and about to have an operation to excise the cancer tissues

Brief summary: Previously published studies have indicated that there exist difference in electrical properties (EPs), i.e., the conductivity and relative permittivity, between malignant and adjacent normal tissue, which will be useful in the early detection of cancers. While the EP informations of cancer tissues are not sufficient enough. The purpose of this study is to measure the electrical properties of the excised malignant tissues obtained from cancer surgeries.

Detailed description: The measurements were conducted in the operating rooms of the hospital where the tissues were excised. Once the tissue was excised from the patient, the pathologist assisted the one of the engineers (already at the hospital) responsible to conduct the measurement. The specimen were designed to permit at least one measurement of malignant tissue and at least one measurement of normal tissue. Occasionally, the measurement of normal tissue was not possible if, for example, the normal tissue occupied a volume of small proportion for every excised specimen. The specimens for dielectric properties measurement were classified as normal or malignant by the pathologist based on his own expertise and decision criteria (visual inspection, anatomy) and the per-operative histological examination. The measurements were directly performed on the bulk specimen. The patient age, tissue temperature at the time of measurement and time between excision and measurement for each sample were recorded.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of cancer Disease

Exclusion Criteria:

* None

Primary outcomes:
measure: Conductivity of Malignant Tissues Measured Ex Vivo
timeFrame: one year
measure: Relative Permittivity of Malignant Tissues Measured Ex Vivo
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Zhujiang Hospital
state: Guangdong
Study officials:
affiliation: School of Biomedical Engineering,Southern Medical University
name: Sherman X Xin, professor
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Bobowski Jake S, Johnson Thomas. Permittivity measurements of biological samples by an open-ended coaxial line. Progress In Electromagnetics Research B 40: 159-183, 2012.
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citation: Smith SR, Foster KR, Wolf GL. Dielectric properties of VX-2 carcinoma versus normal liver tissue. IEEE Trans Biomed Eng. 1986 May;33(5):522-4. doi: 10.1109/TBME.1986.325740. No abstract available.
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