Clinical trial NCT05696990: 3/7 Resistance Training Method in Cardiac Rehabilitation
Official title: 3/7 Resistance Training Method in Cardiac Rehabilitation of Coronary Artery Disease and Heart Failure With Reduced Ejection Fraction
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Failure
Coronary Artery Disease
Keywords: cardiac rehabilitation
resistance training
strength training
exercise for older adults
Lead sponsor: Université Libre de Bruxelles
Sponsor class: OTHER
First posted: 2023-01-25
Enrollment: 112
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aim of the clinical monocentric study is to assess the resistance training exercise intervention in patients with Heart Failure with reduced Ejection Fraction (HFrEF) and coronary artery disease that will best improve peak oxygen uptake (Peak Vo2) and leg strength (assessed Isokinetic). The investigators hypothesize that resistance training exercise with induced a high stress metabolic is more important exercise with induced than a lower stress metabolic.


Eligibility criteria: Inclusion Criteria:

* Clinical Coronary artery diseases
* Heart failure with reduced ejection fraction

Exclusion Criteria:

* angina
* acutely decompensated heart failure
* electrocardiographic evidence of ischemia
* significant valvular disease
* orthopedic/neurologic disorders that limited exercise

Primary outcomes:
measure: Change in Peak VO2 after 3 months
timeFrame: Baseline and 3 months
measure: Change in strength knee extensor after 3 months
timeFrame: Baseline and 3 months
Secondary outcomes:
measure: Change in VE/VCO2 slope after 3 months
timeFrame: Baseline and 3 months
measure: Change in submaximal exercise capacity after 3 months
timeFrame: Baseline and 3 months
measure: Change in workload maximal after 3 months
timeFrame: Baseline and 3 months
measure: Change in Body fat after 3 months
timeFrame: Baseline and 3 months
measure: Change in lean mass after 3 months
timeFrame: Baseline and 3 months
measure: Change in leg lean mass after 3 months
timeFrame: Baseline and 3 months
measure: Change in bone mass after 3 months
timeFrame: Baseline and 3 months
measure: Change in Visceral adipose tissue after 3 months
timeFrame: Baseline and 3 months
measure: Change in hand grip force after 3 months
timeFrame: Baseline and 3 months
measure: Change in ventilation metaboreflex function after 3 months
timeFrame: Baseline and 3 months
measure: Change in diastolic blood pressure metaboreflex function after 3 months
timeFrame: Baseline and 3 months
measure: Change in heart rate at rest after 3 months
timeFrame: Baseline and 3 months
measure: Change in resting heart rate variability at rest after 3 months
timeFrame: Baseline and 3 months
measure: Change 30 s sit-to-stand after 3 months
timeFrame: Baseline and 3 months
measure: Change in isometric strength knee extensor after 3 months
timeFrame: Baseline and 3 months
measure: Change in 120°/sec strength knee extensor after 3 months
timeFrame: Baseline and 3 months
measure: Change in 180°/sec strength knee extensor after 3 months
timeFrame: Baseline and 3 months
measure: Change strength knee extensor in leg extension after 3 months
timeFrame: Baseline and 3 months
measure: Change in sub maximal strength knee extensor in leg extension after 3 months
timeFrame: Baseline and 3 months
measure: Change in heart rate recovery after 3 months
timeFrame: Baseline and 3 months
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Erasme Hospital
Study officials:
affiliation: Université Libre de Bruxelles
name: Alexis Gillet
role: PRINCIPAL_INVESTIGATOR
References:
citation: Stragier S, Baudry S, Carpentier A, Duchateau J. Efficacy of a new strength training design: the 3/7 method. Eur J Appl Physiol. 2019 May;119(5):1093-1104. doi: 10.1007/s00421-019-04099-5. Epub 2019 Feb 12.
citation: Duchateau J, Stragier S, Baudry S, Carpentier A. Strength Training: In Search of Optimal Strategies to Maximize Neuromuscular Performance. Exerc Sport Sci Rev. 2021 Jan;49(1):2-14. doi: 10.1249/JES.0000000000000234.