Clinical trial NCT03424668: The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study
Official title: The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms
Cardiovascular Diseases
Death
Keywords: nutrition
physical activity
lifestyle
smoking
Lead sponsor: University of Cambridge
Sponsor class: OTHER
Collaborators: name: Medical Research Council
name: Cancer Research UK
First posted: 2018-02-07
Enrollment: 25639
Sex: ALL
Minimum age (years): 39
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Resident in Norfolk, United Kingdom on general practice age sex registers 1993-1997

Brief summary: The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease.

Detailed description: The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease. Detailed data on sociodemographic, lifestyle, medical and family history were collected and a biological sample bank including urine and blood samples established. Participants have been followed up through repeat examinations, mailed questionnaires as well as through record linkage with routine health records including death certification by cause, cancer registration and hospital admissions by cause till present.

Eligibility criteria: Inclusion Criteria:

* Willing to participate
* On general practice age sex registers in Norfolk, United Kingdom in 1993-1997

Exclusion Criteria:

* Not willing to participate in study
* terminal illness

Primary outcomes:
measure: neoplasms
timeFrame: Through 25 years
Secondary outcomes:
measure: cardiovascular diseases
timeFrame: through 25 years
measure: death
timeFrame: through 25 years
Other outcomes:
measure: fractures
timeFrame: through 25 years
measure: diabetes mellitus
timeFrame: through 25 years
Locations:
Study officials:
affiliation: University of Cambridge
name: Nicholas Wareham, MBBS
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Cambridge
name: Kay-Tee Khaw, MBBChir
role: PRINCIPAL_INVESTIGATOR
References:
citation: Day N, Oakes S, Luben R, Khaw KT, Bingham S, Welch A, Wareham N. EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. Br J Cancer. 1999 Jul;80 Suppl 1:95-103. No abstract available.
citation: Bingham SA, Welch AA, McTaggart A, Mulligan AA, Runswick SA, Luben R, Oakes S, Khaw KT, Wareham N, Day NE. Nutritional methods in the European Prospective Investigation of Cancer in Norfolk. Public Health Nutr. 2001 Jun;4(3):847-58. doi: 10.1079/phn2000102.