louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06014164: Qualitative Study About Psychedelics Using in Psychiatric Disorders
Official title: Qualitative Study of the Self-administered Therapeutic Use of Psychedelics in People With Psychiatric Disorders
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Psychiatric Disorder
Keywords: Psychiatric disorder
Psychedelics
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2023-08-28
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults patients self-administering psychodelic substances for therapeutic purposes

Brief summary: This study is set up to better understand the current use of psychedelics in France in the general population. The present focus on individuals who have used any type of psychedelic drug in order to suppress or alleviate a psychiatric symptom in the context of a diagnosed pathology. The data are collected during a semi-structured interview and then studied in a thematic analysis.


Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with a psychiatric disorder by a psychiatrist or general practitioner
* Patients used psychedelic or related substances in order to treat psychiatric symptoms
* Patients have given their oral non-opposition
* Patients affiliated to a social security scheme

Exclusion Criteria:

* Patients who don't speak or understand French
* Patients under protection, guardianship or curators

Primary outcomes:
measure: Experiences of people using psychedelic substances
timeFrame: Baseline
Secondary outcomes:
measure: Profile of people using psychedelic substances
timeFrame: Baseline
Other outcomes:
Locations:
Study officials:
affiliation: University Hospital, Toulouse
name: Antoine YRONDI, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02765464: Acute Kidney Injury in Critically Ill Patients
Official title: Predicting Acute Kidney Injury in Critically Ill Trauma Patients Using Metalloproteinase 2 (TIMP2) and Insulin-like Growth Factor Binding Protein7 (IGFBP 7)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Renal Injury
Lead sponsor: Loma Linda University
Sponsor class: OTHER
First posted: 2016-05-06
Enrollment: 50
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects must be trauma patients with multiple injuries.

Brief summary: Acute kidney injury (AKI) in critically ill trauma patients has been shown to significantly increase mortality, length of stay, and costs, however detection has proven difficult as markers like elevated creatinine and decreased urine output may take days to manifest and are late indicators of AKI. The combination of two urinary biomarkers, Tissue Inhibitor of Metalloproteinase 2 (TIMP-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7), has been shown to increase within 12 hours following renal insult, allowing assessment of risk for developing acute kidney injury. Therefore, the investigators plan to assess if acute kidney injury in critically ill trauma patients can be determined earlier using urinary TIMP-2 and IGFBP-7 via the NephroCheck testing system. These markers have not been specifically evaluated in trauma patients at risk of AKI.


Eligibility criteria: Inclusion Criteria:

* trauma patients with multiple injuries;
* abdominal injuries;
* crush injuries;
* those who present in shock (systolic blood pressure \<90 or mean arterial pressure \<65);
* require blood transfusions, vasopressors or mechanical ventilation

Exclusion Criteria:

* known pregnancy;
* patients under 21 years of age;
* known moderate to severe AKI prior to enrollment and end stage renal disease. known moderate to severe AKI prior to enrollment and end stage renal disease

Primary outcomes:
measure: Measurement of u rinary metalloproteinase 2 (TIMP-2) and Insulin-like growth factor binding protein 7 (IGFBP-7) biomarker elevation that corresponds to acute kidney injury by creatinine and urine output
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Loma Linda
country: United States
facility: Loma Linda University Medical Center
state: California
Study officials:
affiliation: Loma Linda University Medical Center
name: Ronak Raval, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05933564: Cognitive Reserve on Pain Catastrophizing and Cognitive Function in Geriatric Patients With Chronic Pain
Official title: The Association Between Cognitive Reserve, Pain Catastrophizing, and Cognitive Function in Geriatric Patients With Chronic Pain: A Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Chronic Pain
Lead sponsor: Ahram Canadian University
Sponsor class: OTHER
First posted: 2023-07-06
Enrollment: 110
Sex: ALL
Minimum age (years): 65
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: FAMILY_BASED
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population consists of community-dwelling adults aged 65-85 years with chronic pain (≥3 months) attributable to osteoarthritis or neuropathic conditions.

Brief summary: To investigate the association between cognitive reserve, pain catastrophizing, and cognitive function in geriatric patients with chronic pain, and to explore whether cognitive reserve moderates the relationship between pain catastrophizing and cognitive function.


Eligibility criteria: Inclusion Criteria:

* Aged 65 to 85 years
* Experiencing chronic pain (≥3 months) attributable to osteoarthritis or neuropathic conditions
* Able to read, write, and speak the language in which assessments are administered
* Willing and able to provide informed consent

Exclusion Criteria:

* Diagnosed with a neurodegenerative disorder (e.g., Alzheimer's disease, Parkinson's disease)
* History of significant head injury, stroke, or brain tumor
* Current substance abuse or dependence
* Severe psychiatric illness (e.g., schizophrenia, bipolar disorder)
* Significant sensory or motor impairments that may interfere with the ability to complete assessments

Primary outcomes:
measure: Association between pain catastrophizing and cognitive function
timeFrame: Baseline assessment
Secondary outcomes:
measure: Moderating effect of cognitive reserve on the association between pain catastrophizing and cognitive function
timeFrame: Baseline assessment
Other outcomes:
Locations:
city: Al Ḩayy Ath Thāmin
country: Egypt
facility: Outpatient clinic of faculty of physical therapy, Ahram Canadian University
state: Giza
Study officials:
affiliation: Faculty of Physical Therapy, Ahram Canadian University
name: Amal Fawzy, Ph.d
role: STUDY_DIRECTOR
References:
Clinical trial NCT00580164: The Role of Splinting in Fingertip Injuries
Official title: The Role of Splinting in Fingertip Injuries
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Injury Distal to Flexor and Extensor Tendon Insertions
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
First posted: 2007-12-24
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Orthopaedic Hand Clinic

Brief summary: This study is attempting to understand whether or not splinting after a fingertip injury improves recovery.


Eligibility criteria: Inclusion Criteria:

* injury distal to flexor and extensor tendon insertions
* crush, avulsion, amputation, or penetrating injury to the fingertip
* isolated injury, within two weeks

Exclusion Criteria:

* operative fixation required
* unable to participate in rehab

Primary outcomes:
measure: DASH questionnaire, Grip strength, and Range of Motion
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Mass General Hospital
state: Massachusetts
Study officials:
affiliation: Massachusetts General Hospital
name: David C Ring, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03995264: Ultrasound vs Palpation for Radial Artery Cannulation
Official title: Ultrasound vs Palpation for Radial Artery Cannulation in Patients Undergoing Bariatic Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obese
Lead sponsor: Ajou University School of Medicine
Sponsor class: OTHER
First posted: 2019-06-24
Enrollment: 30
Sex: ALL
Minimum age (years): 19
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary purpose of this study is to compare the palpation technique with ultrasound guidance for radial artery cannulation for bariatic surgery.


Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists 1, 2, 3 BMI ≥ 30 bariatic surgery

Exclusion Criteria:

* refusal infection or surgery history in wrist

Primary outcomes:
measure: Success rate
timeFrame: at first attempt, as average 5 min
Secondary outcomes:
Other outcomes:
Locations:
city: Suwon
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine
state: Seoul
Study officials:
References:
citation: Flumignan RL, Trevisani VF, Lopes RD, Baptista-Silva JC, Flumignan CD, Nakano LC. Ultrasound guidance for arterial (other than femoral) catheterisation in adults. Cochrane Database Syst Rev. 2021 Oct 12;10(10):CD013585. doi: 10.1002/14651858.CD013585.pub2.
Clinical trial NCT06649864: Adipose-Derived Mesenchymal Stem Cell for Preventing Biliary Complications
Official title: A Phase I Study of Autologous Adipose-derived Mesenchymal Stromal Cells in Preventing Biliary Complications After Living Donor Liver Transplant
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE1
Conditions: Liver Transplant; Complications
Liver Diseases
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2024-10-21
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the safety of autologous Adipose-Derived Mesenchymal Stem Cell for use in End-Stage Liver Disease patients undergoing the creation of a duct-to-duct anastomosis during Living Donor Liver Transplantation.


Eligibility criteria: Inclusion Criteria

* Listed for liver transplantation
* Non-pediatric patients with a planned LDLT
* Ability to communicate with investigative staff
* Competence to give written informed consent
* Ability to comply with the entire study procedure
* All sexes and genders will be eligible for the study

Exclusion Criteria

* Planned deceased donor liver transplantation
* Uncontrolled / unresolved local or systemic infection
* Body mass index \> 40
* Planned pancreaticoduodenectomy or sleeve gastrectomy
* Anticipation of 3 biliary anastomoses (we will include those anticipated to have 1 or 2 biliary anastomoses as detailed below)
* Pregnancy or breastfeeding
* Non-liver cancers (we will include certain patients with primary liver cancer as detailed below)
* Treatment with any investigational drug / device within 60 days prior to study entry
* Any other condition which in the judgment of the investigator would preclude adequate evaluation of the safety and efficacy of AMSCs
* Patients who are employees or relatives of the investigator

Primary outcomes:
measure: Side effects
timeFrame: 24 months
Secondary outcomes:
measure: Biliary complications
timeFrame: 24 months
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Julie Heimbach
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02574364: Abdomen CT and Open Appendicectomy：New Diagnostic and Surgical Procedures
Official title: Abdomen CT and Open Appendicectomy：New Diagnostic and Surgical Procedures
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Wound Infection
Complication
Scar
Keywords: abdomen CT
open appendicectomy
Lead sponsor: Ningbo Municipal No.4 Hospital
Sponsor class: OTHER_GOV
First posted: 2015-10-12
Enrollment: 730
Sex: ALL
Minimum age (years): 15
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The traditional open appendectomy in the clinical effect is not prefect, and for a long time there is no measurable improvement. The application of abdomen CT before surgery provides a new approach to the incision and new perception.

In a randomized controlled trial of modified incision versus traditional incision. Length of hospital day was the primary terminus, while operating time, postoperative complication, scar and time to resume normal activity and work as secondary terminus.

Detailed description: Traditional open appendicectomy have many drawbacks, such as false-positive, cut infection, scar, extended cut, slower rehabilitation and return to work. In the past few years, in order to improve diagnostic accuracy, the abdomen CT is been general applied before appendicectomy, in addition to, a modified incision (MI) was designed based on it. Using a MI compare traditional incision (TI) to the patient including cut extended, operating time, cut infection, false-positive rate, rehabilitation and return to work. It seems that MI would prove superior to TI in terms of hospital day (primary terminus), with operating time, postoperative complication, scar and time to resume normal activity and work as secondary terminus.

Eligibility criteria: Inclusion Criteria:

* patients with a clinical diagnosis of acute appendicitis

Exclusion Criteria:

* children under 14 are not included

Primary outcomes:
measure: hospital day
timeFrame: 2 weeks
Secondary outcomes:
measure: time to return to normal activity and work in days
timeFrame: up to 4 weeks
measure: operating time in minutes
timeFrame: 180 Minutes
measure: numbers of extended cut, numbers of infection,numbers of intraperitoneal abscess
timeFrame: 1 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03658564: Preoperative Oral Carbohydrate Treatment Minimizes Insulin Resistance
Official title: Preoperative Oral Carbohydrate Treatment in Diabetes Patients: A Randomized, Double-blind Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Insulin Resistance
Keywords: Insulin resistance
Diabetes mellitus
Carbohydrate
Lead sponsor: The Second Affiliated Hospital of Dalian Medical University
Sponsor class: OTHER
First posted: 2018-09-05
Enrollment: 80
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Insulin resistance is a positive protective reaction against surgery .this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.

Detailed description: Insulin resistance is a positive protective reaction against surgery . As a response to surgery, activation of neuroendocrine and inflammation systems occurs as a protective reaction. However, this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.

Eligibility criteria: Inclusion Criteria:

* patients underwent elective open colorectal resection for colorectal carcinoma and electric orthopedic surgery

Exclusion Criteria:

* Weight loss greater than 10 per cent during the previous 6 months
* Renal insufficiency (creatinine, \> 3 mg/dl; hemodialysis)
* Hepatic insufficiency (Child-Pugh class, ≥ B)
* Gastro-oesophageal reflux disease
* Gastrointestinal obstruction or conditions (including pharmacological treatment) known to affect gastric emptying rate

Primary outcomes:
measure: VAS
timeFrame: 1 day (preoperative period)
Secondary outcomes:
measure: HOMA
timeFrame: perioperative period)
Other outcomes:
Locations:
city: Dalian
country: China
facility: The Second Hospital of Dalian Medical University
state: Liaoning
Study officials:
affiliation: 0866-17709873399
name: yang z Xiao, MD,PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05702164: Physiotherapy and Rehabilitation Students' Incontinence Knowledge Level
Official title: Investigation of Physiotherapy and Rehabilitation Students' Incontinence Knowledge Level and Attitudes Towards Treatment
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Health Knowledge, Attitudes, Practice
Keywords: Physiotherapy
rehabilitation
knowledge
incontinence
attitude
therapy
Lead sponsor: Nigde Omer Halisdemir University
Sponsor class: OTHER
Collaborators: name: Ankara Yildirim Beyazıt University
name: Gazi University
First posted: 2023-01-27
Enrollment: 260
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Physiotherapy and rehabilitation students in Turkey.

Brief summary: The aim of the study is to examine the urinary incontinence knowledge level and attitudes towards treatment in Physiotherapy and Rehabilitation students. With this study, students' knowledge levels about urinary incontinence and treatment parameters will be determined, and it will be possible to show whether there is a difference between genders in terms of knowledge levels.

Detailed description: The aim of the study is to examine the urinary incontinence knowledge level and attitudes towards treatment in Physiotherapy and Rehabilitation students. With this study, students' knowledge levels about urinary incontinence and treatment parameters will be determined, and it will be possible to show whether there is a difference between genders in terms of knowledge levels.

At least 260 students studying in the Physiotherapy and Rehabilitation Department in Turkey will be included in the study.

Eligibility criteria: Inclusion Criteria:

* Being a student of Physiotherapy and Rehabilitation department in Turkey
* Being volunteer

Exclusion Criteria:

- Failing to complete surveys

Primary outcomes:
measure: General information form
timeFrame: Baseline
measure: Incontinence Quiz
timeFrame: Baseline
measure: Pelvic Floor Health Knowledge Quiz
timeFrame: Baseline
measure: Prolapse and Incontinence Knowledge Questionnaire
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazi University
Study officials:
References:
Clinical trial NCT03046264: Invasive Validation of Non-invasive Central Blood Pressure Measurements Using Oscillometric Pulse Wave Analysis
Official title: Non-invasive Automated Central Blood Pressure Measurements Using Oscillometric Pulse Wave Analysis - Comparison With Invasive Reference Values
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Arterial Hypertension
Coronary Heart Disease
Keywords: central blood pressure
measurement
oscillometric radial pulse wave analysis
Lead sponsor: Universitätsmedizin Mannheim
Sponsor class: OTHER
First posted: 2017-02-08
Enrollment: 106
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients undergoing routine coronary angiography with diagnostic or therapeutic indication

Brief summary: There is growing evidence that central blood pressure is a better predictor of hypertensive end-organ damage and cardiovascular outcome than routine brachial readings.

The investigators aimed to evaluate the accuracy of a novel device for the non-invasive determination of central blood pressure based on automated oscillometric radial pulse wave analysis.


Eligibility criteria: Inclusion Criteria:

* patients undergoing routine coronary angiography

Exclusion Criteria:

* inability to give informed consent
* hemodynamic instability

Primary outcomes:
measure: agreement of systolic central blood pressure measurements
timeFrame: 15 minutes
measure: agreement of diastolic central blood pressure measurements
timeFrame: 15 minutes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Universitätsmedizin Mannheim
name: Jens J Kaden, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Universitätsmedizin Mannheim
name: Joachim Saur, MD
role: PRINCIPAL_INVESTIGATOR
References: