Clinical trial NCT00257608: A Study Comparing Bevacizumab Therapy With or Without Erlotinib for First-Line Treatment of Non-Small Cell Lung Cancer (ATLAS)
Official title: A Randomized, Double-Blind, Placebo-Controlled, Phase IIIb Trial Comparing Bevacizumab Therapy With or Without Erlotinib After Completion of Chemotherapy With Bevacizumab for the First-Line Treatment of Locally Advanced, Recurrent, or Metastatic Non-Small Cell Lung Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Non-Small Cell Lung Cancer
Keywords: NSCLC
Lung Cancer
ATLAS
Avastin
Tarceva
Lead sponsor: Genentech, Inc.
Sponsor class: INDUSTRY
First posted: 2005-11-23
Enrollment: 1145
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a Phase IIIb, multicenter, randomized, placebo-controlled trial to evaluate the safety and efficacy of chemotherapy+bevacizumab followed by bevacizumab+erlotinib versus bevacizumab+erlotinib placebo in subjects with locally advanced or metastatic NSCLC.


Eligibility criteria: Inclusion Criteria:

* Signed Informed Consent Form
* Histologically or cytologically confirmed NSCLC
* Advanced NSCLC or recurrent disease
* INR no greater than 1.3 and aPTT no greater than upper limits of normal (ULN) within 28 days prior to enrollment for subjects not on low molecular weight heparin or fondaparinux. Subjects on low molecular weight heparin or fondaparinux are not required to meet INR or aPTT limits. Chronic full-dose anticoagulation with warfarin is not permitted.
* 18 years of age or older
* For women of childbearing potential and sexually active men, use of an accepted and effective method of contraception (hormonal or barrier methods, abstinence) prior to enrollment and for the duration of the study

Exclusion Criteria:

* Prior systemic chemotherapy in the metastatic setting
* Treatment with an investigational or marketed agent that acts by either EGFR inhibition or anti-angiogenesis mechanisms
* Pregnancy or lactation
* Any other medical condition, including mental illness or substance abuse, deemed by the clinician to be likely to interfere with a subject's ability to provide informed consent, cooperate, and participate in the study, or to interfere with the interpretation of the results
* Active infection or a fever within 3 days of enrollment
* Active malignancy other than lung cancer
* Radiation therapy to sites other than whole brain within 14 days prior to enrollment
* History of gross hemoptysis within 3 months prior to enrollment
* Known hypersensitivity to any of the components of cytotoxic chemotherapy combinations, bevacizumab, or tyrosine kinase inhibitors
* Inadequately controlled hypertension
* Unstable angina or New York Heart Association Grade II or greater CHF
* Abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to enrollment
* History of myocardial infarction within 6 months prior to enrollment
* History of stroke within 6 months prior to enrollment
* Symptomatic peripheral vascular disease within 6 months prior to enrollment
* Evidence of bleeding diathesis or coagulopathy
* Serious, non-healing wound, ulcer, or bone fracture
* Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to enrollment; anticipation of need for major surgical procedure during the course of the study
* Current, recent, or planned participation in an experimental drug study other than this Genentech-sponsored bevacizumab/erlotinib study
* Progressive neurologic symptoms in subjects with a history of brain metastases
* History of significant vascular disease (e.g., aortic aneurysm)

Primary outcomes:
measure: Progression-free Survival (PFS)
timeFrame: Approximately 3 years
Secondary outcomes:
measure: Number of Participants With Prospectively Identified Treatment Emergent Adverse Events (TEAE) During Chemotherapy Phase
timeFrame: Approximately 3 years
measure: Number of Participants With Prospectively Identified Treatment Emergent Adverse Events (TEAE) During Post-Chemotherapy Phase
timeFrame: Approximately 3 years
measure: Number of Participants With Any Adverse Events During Post-Chemotherapy Phase
timeFrame: Approximately 3.5 years
measure: Incidence of Study Treatment Discontinuation for Reasons Other Than Disease Progression in Chemotherapy Phase
timeFrame: Approximately 3 years
measure: Incidence of Study Treatment Discontinuation
timeFrame: Approximately 3 years
measure: Overall Survival
timeFrame: Approximately 3.5 years
Other outcomes:
Locations:
city: Mobile
country: United States
facility: Sacred Heart Medical Onc Group
state: Alabama
city: Ft Smith
country: United States
facility: St. Edward Mercy Medical Ctr
state: Arizona
city: Scottsdale
country: United States
facility: Mayo Clinic
state: Arizona
city: Tucson
country: United States
facility: Arizona Cancer Center
state: Arizona
city: Alhambra
country: United States
facility: Central Hem/Onc Medical Group
state: California
city: Bakersfield
country: United States
facility: Comp Blood & Cancer Center
state: California
city: Campbell
country: United States
facility: South Bay Oncology
state: California
city: Concord
country: United States
facility: Bay Area Cancer Research Grp
state: California
city: Encinitas
country: United States
facility: Pacific Onc & Hem Assoc
state: California
city: Fountain Valley
country: United States
facility: Pacific Coast Hem/Onc
state: California
city: Fresno
country: United States
facility: Cancer Care Associates
state: California
city: Fullerton
country: United States
facility: St. Jude Heritage Med Group
state: California
city: Gilroy
country: United States
facility: Ronald H. Yanagihara
state: California
city: Glendale
country: United States
facility: Glendale Adventist Medical Ctr
state: California
city: La Jolla
country: United States
facility: Scipps Clinic
state: California
city: Loma Linda
country: United States
facility: Loma Linda Univ Medical Center
state: California
city: Long Beach
country: United States
facility: Pacific Shores Medical Group
state: California
city: Los Angeles
country: United States
facility: Kenmar Research Institute LLC
state: California
city: Los Angeles
country: United States
facility: UCLA Medical Ctr
state: California
city: Modesto
country: United States
facility: Sutter Gould Med Foundation
state: California
city: Northridge
country: United States
facility: North Valley Hem Onc Med Grp
state: California
city: Orange
country: United States
facility: Hem Onc Med Grp Orange Cty
state: California
city: Orange
country: United States
facility: Medical Oncology Care Assoc
state: California
city: Oxnard
country: United States
facility: Ventura Co Hem-Onc Specialists
state: California
city: Pomona
country: United States
facility: Wilshire Oncology Medical Grp
state: California
city: Sacramento
country: United States
facility: Sutter Cancer Center
state: California
city: Sacramento
country: United States
facility: Mercy General Hospital
state: California
city: Salinas
country: United States
facility: Los Palos Oncology & Hem
state: California
city: San Diego
country: United States
facility: Kaiser Permanente
state: California
city: San Diego
country: United States
facility: Naval Medical Center
state: California
city: San Francisco
country: United States
facility: Pacific Hematology Oncology
state: California
city: San Jose
country: United States
facility: Kaiser Permanente Santa Teresa
state: California
city: Santa Barbara
country: United States
facility: Sansum Medical Clinic, Inc.
state: California
city: Santa Barbara
country: United States
facility: Santa Barbara Hem Onc Med Grp
state: California
city: Santa Maria
country: United States
facility: Central Coast Medical Oncology
state: California
city: Santa Monica
country: United States
facility: The Angeles Clinic
state: California
city: Santa Rosa
country: United States
facility: Redwood Regional Med Grp
state: California
city: Torrance
country: United States
facility: Cancer Care Associates
state: California
city: Denver
country: United States
facility: Mile High Oncology
state: Colorado
city: Fort Collins
country: United States
facility: Front Range Cancer Specialists
state: Colorado
city: Washington
country: United States
facility: Washington Onc Hem Center PC
state: District of Columbia
city: Boca Raton
country: United States
facility: Center for Hematology-Oncology
state: Florida
city: Daytona Beach
country: United States
facility: Halifax Medical Center
state: Florida
city: Inverness
country: United States
facility: Florida Wellcare Alliance
state: Florida
city: Jacksonville
country: United States
facility: Baptist Cancer Institute
state: Florida
city: Miami
country: United States
facility: Jackson Memorial Hospital
state: Florida
city: Orange City
country: United States
facility: Mid-Florida Hem Oncology Ctr
state: Florida
city: Orange Park
country: United States
facility: Integrated Comm Onc Network
state: Florida
city: Port Saint Lucie
country: United States
facility: Hematology Onc Treasure Coast
state: Florida
city: Albany
country: United States
facility: Phoebe Putney Cancer Center
state: Georgia
city: Athens
country: United States
facility: Northeast Georgia Cancer Care
state: Georgia
city: Lawrenceville
country: United States
facility: Suburban Hem-Onc Associates
state: Georgia
city: Marietta
country: United States
facility: Northwest Georgia Onc Centers
state: Georgia
city: Arlington Heights
country: United States
facility: Chicagoland Hematology Onc
state: Illinois
city: Chicago
country: United States
facility: Weiss-Strauss Oncology Center
state: Illinois
city: Geneva
country: United States
facility: LaGrange Oncology Associates
state: Illinois
city: Lagrange
country: United States
facility: La Grange Oncology Associates
state: Illinois
city: Oak Lawn
country: United States
facility: Associates in Medical Oncology
state: Illinois
city: Peoria
country: United States
facility: Onc Hem Assoc of Central IL
state: Illinois
city: River Forest
country: United States
facility: West Suburban Cancer Center
state: Illinois
city: Rockford
country: United States
facility: OSF St. Anthony Med Ctr
state: Illinois
city: Munster
country: United States
facility: Community Hospital
state: Indiana
city: Terre Haute
country: United States
facility: Providence Medical Group
state: Indiana
city: Bettendorf
country: United States
facility: Hematology Oncology Associates
state: Iowa
city: Sioux City
country: United States
facility: Siouxland Hem-Onc Assoc LLP
state: Iowa
city: Waterloo
country: United States
facility: Covenant Clinic
state: Iowa
city: Hopkinsville
country: United States
facility: Gajera & Patel, PLLC
state: Kentucky
city: Louisville
country: United States
facility: Kentuckiana Cancer Center
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville
state: Kentucky
city: Louisville
country: United States
facility: Consultants in Blood Disorders
state: Kentucky
city: Owensboro
country: United States
facility: Owensboro Medical Health Sys
state: Kentucky
city: Shreveport
country: United States
facility: Willis-Knighton Cancer Center
state: Louisiana
city: Baltimore
country: United States
facility: H&J Weinberg Cancer Institute
state: Maryland
city: Clinton
country: United States
facility: Oncology Hematology Associates
state: Maryland
city: Columbia
country: United States
facility: Maryland Oncology/Hema PA
state: Maryland
city: Frederick
country: United States
facility: Frederick Memorial Hospital
state: Maryland
city: Boston
country: United States
facility: Dana Farber Cancer Institute
state: Massachusetts
city: Boston
country: United States
facility: Caritas St. Elizabeth Med Ctr
state: Massachusetts
city: Burlington
country: United States
facility: Lahey Clinic Med Ctr
state: Massachusetts
city: Framingham
country: United States
facility: Metrowest Cancer Center
state: Massachusetts
city: Springfield
country: United States
facility: Baystate Medical Center
state: Massachusetts
city: Grand Rapids
country: United States
facility: Spectrum Health
state: Michigan
city: Kalamazoo
country: United States
facility: Kalamazoo Hem & Onc
state: Michigan
city: Marquette
country: United States
facility: Marquette General Health Sys
state: Michigan
city: Pontiac
country: United States
facility: St. Joseph Mercy Oakland
state: Michigan
city: Royal Oak
country: United States
facility: William Beaumont Hospital
state: Michigan
city: Minneapolis
country: United States
facility: Virginia Piper Cancer Inst
state: Minnesota
city: Columbia
country: United States
facility: Ellis Fischel Cancer Center
state: Missouri
city: Joplin
country: United States
facility: Freeman Cancer Institute
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis Univ Care Center
state: Missouri
city: St Charles
country: United States
facility: Missouri Cancer Center, PC
state: Missouri
city: Washington
country: United States
facility: Arch Medical Services
state: Missouri
city: Billings
country: United States
facility: Billings Clinic
state: Montana
city: Great Falls
country: United States
facility: Big Sky Oncology
state: Montana
city: Missoula
country: United States
facility: Montana Cancer Specialists
state: Montana
city: Lincoln
country: United States
facility: NE Hematology Oncology, PC
state: Nebraska
city: Omaha
country: United States
facility: Nebraska Methodist Hospital
state: Nebraska
city: Las Vegas
country: United States
facility: Comp Cancer Centers of Nevada
state: Nevada
city: Cherry Hill
country: United States
facility: Ctr for Cancer & Hem Disease
state: New Jersey
city: Englewood
country: United States
facility: Forte, Attas & Schleider
state: New Jersey
city: Flemington
country: United States
facility: Hunterdon Medical Center
state: New Jersey
city: Freehold
country: United States
facility: Central State Medical Center
state: New Jersey
city: Livingston
country: United States
facility: St. Barnabas Health Care Sys
state: New Jersey
city: Montclair
country: United States
facility: Mountainside Hospital
state: New Jersey
city: Morristown
country: United States
facility: Morristown Memorial Hospital
state: New Jersey
city: Mount Holly
country: United States
facility: Hematology Oncology Assoc SJ
state: New Jersey
city: Neptune
country: United States
facility: Jersey Shore Medical Center
state: New Jersey
city: New Brunswick
country: United States
facility: Cancer Institute of New Jersey
state: New Jersey
city: Paramus
country: United States
facility: The Valley Hospital
state: New Jersey
city: Summit
country: United States
facility: Overlook Hospital
state: New Jersey
city: Teaneck
country: United States
facility: Holy Name Hospital
state: New Jersey
city: Farmington
country: United States
facility: San Juan Onco Assoc
state: New Mexico
city: Buffalo
country: United States
facility: Zale P Bernstein MD - PP
state: New York
city: Cooperstown
country: United States
facility: Bassett Cancer Center
state: New York
city: Glen Falls
country: United States
facility: Adriondack Cancer Care
state: New York
city: Great Neck
country: United States
facility: BRANY
state: New York
city: Jamaica
country: United States
facility: Queens Cancer Center
state: New York
city: Middletown
country: United States
facility: Crystal Run Health Care
state: New York
city: New York
country: United States
facility: NYU Medical Center
state: New York
city: New York
country: United States
facility: Mem Sloan Kettering Cancer Ctr
state: New York
city: Syracuse
country: United States
facility: SUNY Upstate
state: New York
city: Charlotte
country: United States
facility: Presbyterian Hospital
state: North Carolina
city: Concord
country: United States
facility: NorthEast Medical Center
state: North Carolina
city: Greensboro
country: United States
facility: Moses Cone Reg Cncr Ctr
state: North Carolina
city: High Point
country: United States
facility: Emerywood Hematology Oncology
state: North Carolina
city: Huntersville
country: United States
facility: Carolina BioOncology Institute
state: North Carolina
city: Kinston
country: United States
facility: Kinston Medical Specialists
state: North Carolina
city: Washington
country: United States
facility: Beaufort County Hospital
state: North Carolina
city: Akron
country: United States
facility: Summa Health System
state: Ohio
city: Akron
country: United States
facility: Akron General Medical Center
state: Ohio
city: Canton
country: United States
facility: Aultman Hospital
state: Ohio
city: Canton
country: United States
facility: Gabrail Cancer Center
state: Ohio
city: Cincinnati
country: United States
facility: Onc/Hem Care Clin Trials LLC
state: Ohio
city: Cleveland
country: United States
facility: MetroHealth Medical Center
state: Ohio
city: Columbus
country: United States
facility: Mid Ohio Onc Hematology Inc
state: Ohio
city: Columbus
country: United States
facility: Riverside Methodist Hospital
state: Ohio
city: Dayton
country: United States
facility: Dayton Clinical Oncology Prog
state: Ohio
city: Mansfield
country: United States
facility: Ohio Cancer Specialists
state: Ohio
city: Middletown
country: United States
facility: Signal Point Hem/Oncology Inc
state: Ohio
city: Toledo
country: United States
facility: Toledo Community Hospital
state: Ohio
city: Youngstown
country: United States
facility: Forum Health Cancer Care Ctr
state: Ohio
city: Portland
country: United States
facility: Providence Portland Med Center
state: Oregon
city: Ephrata
country: United States
facility: Ephrata Cancer Center
state: Pennsylvania
city: Kittanning
country: United States
facility: Armstrong County Memorial Hosp
state: Pennsylvania
city: Lancaster
country: United States
facility: Hem Onc Assoc Phys Lancaster
state: Pennsylvania
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
city: Scranton
country: United States
facility: Scranton Hematology Oncology
state: Pennsylvania
city: Upland
country: United States
facility: Assoc in Hematology Oncology
state: Pennsylvania
city: Wynnewood
country: United States
facility: Lankenau Medical Office Bldg
state: Pennsylvania
city: Charleston
country: United States
facility: Charleston Cancer Center
state: South Carolina
city: Spartanburg
country: United States
facility: Palmetto Hematology Oncology
state: South Carolina
city: Chattanooga
country: United States
facility: Erlanger Health Systems
state: Tennessee
city: Germantown
country: United States
facility: The Jones Clinic
state: Tennessee
city: Jackson
country: United States
facility: Jackson-Madsion County Hosp
state: Tennessee
city: Memphis
country: United States
facility: Clopton Clinic
state: Tennessee
city: Nashville
country: United States
facility: Sarah Cannon Cancer Center
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical
state: Tennessee
city: Austin
country: United States
facility: Lone Star Oncology Consultants
state: Texas
city: Corpus Christi
country: United States
facility: Coastal Bend Cancer Center
state: Texas
city: Dallas
country: United States
facility: Texas Cancer Associates
state: Texas
city: Dallas
country: United States
facility: Texas Hematology Oncology
state: Texas
city: Fort Worth
country: United States
facility: JPS Center for Cancer Care
state: Texas
city: Galveston
country: United States
facility: Univ of Texas Medical Branch
state: Texas
city: Lackland AFB
country: United States
facility: Wilford Hall Medical Center
state: Texas
city: Bennington
country: United States
facility: SW Vermont Healthcare Onc Asoc
state: Vermont
city: Colchester
country: United States
facility: Vermont Ctr Cancer Medicine
state: Vermont
city: Rutland
country: United States
facility: Community Cancer Center
state: Vermont
city: Newport News
country: United States
facility: Peninsula Cancer Institute
state: Virginia
city: Roanoke
country: United States
facility: SW Virginia Hem Onc
state: Virginia
city: Kirkland
country: United States
facility: Cascade Cancer Center
state: Washington
city: Tacoma
country: United States
facility: Northwest Medical Specialists
state: Washington
city: Huntington
country: United States
facility: Univ Physicians Internal Med
state: West Virginia
city: Morgantown
country: United States
facility: West Virginia University
state: West Virginia
city: Glendale
country: United States
facility: Oncology Alliance
state: Wisconsin
city: Madison
country: United States
facility: Dean Clinic
state: Wisconsin
city: Milwaukee
country: United States
facility: Medical Consultants LTD
state: Wisconsin
city: Racine
country: United States
facility: All Saints Cancer Center
state: Wisconsin
city: Buenos Aires
country: Argentina
facility: Hospital Pirovano
city: Buenos Aires
country: Argentina
facility: Hospital Britanico
city: Buenos Aires
country: Argentina
facility: Hospital Toru
city: Buenos Aires
country: Argentina
facility: CEMIC
city: Cordoba
country: Argentina
facility: Centro Oncologico de Cordoba
city: Mendoza
country: Argentina
facility: COIR
city: Resistencia
country: Argentina
facility: Instituto Medico Privado
city: Rosario
country: Argentina
facility: Clinica Oncologica de Rosario
city: Sante Fe
country: Argentina
facility: ISIS Clinica Especializada
city: Chermside, QLD
country: Australia
facility: Holy Spirit Hospital Northside
city: Nambour, QLD
country: Australia
facility: Sunshine Coast Cancer Centre
city: Nedlands, WA
country: Australia
facility: Sir Charles Gairdner Hospital
city: Toorak Gardens, SA
country: Australia
facility: Burnside War Memorial Hospital
city: Brussels
country: Belgium
facility: Cliniques Univ St Luc
city: Liege
country: Belgium
facility: CHR Citadelle Liege
city: Rio de Janeiro
country: Brazil
facility: Instituto Nacional do Cancer
city: Sao Paulo
country: Brazil
facility: Instituto de cancer Arnaldo
city: Sao Paulo
country: Brazil
facility: Hospital Das Clinicas
city: Plovdiv
country: Bulgaria
facility: Regional Oncodispensary
city: Rousse
country: Bulgaria
facility: Regional Oncodispensary
city: Shoumen
country: Bulgaria
facility: Regional Oncodispensary
city: Sofia
country: Bulgaria
facility: Regional Oncodispensary
city: Sofia
country: Bulgaria
facility: UMHAT "Queen Joanna"
city: Sofia
country: Bulgaria
facility: National Specialized Hospital
city: Stara Zagora
country: Bulgaria
facility: Regional Oncodispensary
city: Varna
country: Bulgaria
facility: MHAT "St Marina"
city: Veliko Tarnovo
country: Bulgaria
facility: Regional Oncodispensary
city: Hong Kong
country: Hong Kong
facility: Princess Margaret Hospital
city: Hong Kong
country: Hong Kong
facility: Queen Elizabeth Hospital
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
city: Hong Kong
country: Hong Kong
facility: Tuen Mun Hospital
city: Jerusalem
country: Israel
facility: Hadassah Medical Center
city: Tel-Aviv
country: Israel
facility: Sourasky Medical Center
city: Tel-Hashomer
country: Israel
facility: Sheba Medical Center
city: Genova
country: Italy
facility: Azienda Ospedaliera Univ
city: Genova
country: Italy
facility: Ist Nazion per Ricerca Cancro
city: Napoli
country: Italy
facility: Univ degli Studi di Napoli
city: Parma
country: Italy
facility: Azienda Ospedaliera
city: Perugia
country: Italy
facility: Azienda Osper di Perugia
city: Udine
country: Italy
facility: Divisione Onc Med dell'Azienda
city: Acapulco
country: Mexico
facility: Torre Medica Cristobal Colon
city: Distrito Federal
country: Mexico
facility: Inst Nacional de Cancerologia
city: Merida
country: Mexico
facility: ISSSTE Merida
city: Torreon, Coahuila
country: Mexico
facility: Hospital de Especialidades
city: Manila
country: Philippines
facility: Philippine General Hospital
state: Luzon
city: Pasig City
country: Philippines
facility: The Medical City
state: Luzon
city: Quezon City
country: Philippines
facility: Veterans Memorial Medical Ctr
state: Luzon
city: Cebu City
country: Philippines
facility: Perpetual Succour Hospital
state: Visayas
city: Manila
country: Philippines
facility: Univ of Santo Tomas Hospital
city: Quezon City
country: Philippines
facility: St Luke's Medical Center
city: Iasi
country: Romania
facility: Centrul de Onc Medical Lasi
city: Sibiu
country: Romania
facility: Spitalul Clinic Judetean Sibiu
city: Suceava
country: Romania
facility: Spitalul Judetean de Urgente
city: Singapore
country: Singapore
facility: National Cancer Center
city: Sabadell
country: Spain
facility: Corporacio Sanitaria Parc
state: Barcelona
city: Barakaldo
country: Spain
facility: Hospital de Cruces
city: Barcelona
country: Spain
facility: Hospital del Mar
city: Barcelona
country: Spain
facility: Hospital Clinic i Provincial
city: La Laguna
country: Spain
facility: Hospital Universitario
city: Valencia
country: Spain
facility: Instituto Valenciano Oncologia
city: Valencia
country: Spain
facility: Hospital Clinico Universitario
city: Taichung
country: Taiwan
facility: China Medical Univ Hosp
city: Taipei
country: Taiwan
facility: National Taiwan University
city: Taiwan
country: Taiwan
facility: Taichung Veterans Gen Hosp
city: Bangkok
country: Thailand
facility: Bumrungrad International Hosp
city: Bangkok
country: Thailand
facility: National Cancer Institute
city: Bangkok
country: Thailand
facility: Pramongkutklao Hospital
city: Bangkok
country: Thailand
facility: Siriraj Hospital
city: Chiangmai
country: Thailand
facility: Maharaj Nakorn Chiang Mai Hosp
city: Bristol
country: United Kingdom
facility: Bristol Heamatology & Onc Ctr
Study officials:
affiliation: Genentech, Inc.
name: Donald Strickland, M.D.
role: STUDY_DIRECTOR
References:
citation: Johnson BE, Kabbinavar F, Fehrenbacher L, Hainsworth J, Kasubhai S, Kressel B, Lin CY, Marsland T, Patel T, Polikoff J, Rubin M, White L, Yang JC, Bowden C, Miller V. ATLAS: randomized, double-blind, placebo-controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib, after completion of chemotherapy, with bevacizumab for first-line treatment of advanced non-small-cell lung cancer. J Clin Oncol. 2013 Nov 1;31(31):3926-34. doi: 10.1200/JCO.2012.47.3983. Epub 2013 Oct 7.