Clinical trial NCT04824001: Exercise Echocardiography on LV Mechanics in Patients With CAD: a Speckle-tracking Echocardiography
Official title: Using Exercise Echocardiography to Investigate the Effects of Different Exercise Trainings on Left Ventricular Mechanics in Patients With Coronary Artery Disease: a Speckle-tracking Echocardiography
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cardiovascular Diseases
STEMI
NSTEMI
Keywords: stress echocardiography
speckle tracking
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2021-04-01
Enrollment: 90
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: acute myocardial infarction diagnosed by a physician and undergoing percutaneous coronary intervention

Brief summary: Recovering blood flow to a coronary stenosis may improve left ventricular (LV) function in patients with coronary artery disease (CAD). However, the reported data about evaluation of LV function post-percutaneous coronary intervention (PCI) in CAD was limited. The aim of this study was to compare the LV function measured by 3 min low dose exercise stress echocardiography (ESE) combined 2D speckle tracking echocardiography (STE) in patients with CAD underwent PCI, and to identify factors affecting the change of LV function. Patients with CAD who underwent acute PCI were enrolled.

Detailed description: The assessment of temporal changes in systolic and diastolic regional left ventricle function by 2D-STE after successful reperfusion therapy of acute myocardial infarction (AMI).The estimated total number of participants is 90 patients with AMI and treated with successful percutaneous coronary intervention were included in this study. The echocardiographic measurements were performed in all patients within in-hotpital after PCI procedure, and then followed up at 7, 14, 30, 60 and 180 days after discharge. Recovery of regional systolic and diastolic myocardial function after acute myocardial infarction evaluated by ESE-STE.

Eligibility criteria: Inclusion Criteria:

* acute myocardial infarction diagnosed by a physician
* undergoing percutaneous coronary intervention
* Exercise testing and stress echocardiography are performed with the approval of the physician.

Exclusion Criteria:

* Severe cardiac valve disease
* Left bundle branch block
* Uncontrolled diabetes or hypertension
* Orthopedics or other conditions that hinder from exercise
* Uncontrolled sinus tachycardia (greater than 120 beats per minute)

Primary outcomes:
measure: The alterations of LV mechanics responses to a 3-min low dose exercise stress echocardiography following time.
timeFrame: detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.
Secondary outcomes:
measure: Cardiopulmonary fitness
timeFrame: detected at the day 30, 60, and 180 after discharge.
measure: The brain-type natriuretic peptide (BNP) levels
timeFrame: detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.
measure: The high-sensitivity CRP (hsCRP) levels
timeFrame: detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.
measure: The creatine kinase (CK) levels
timeFrame: detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.
measure: The creatine kinase-MB (CK-MB) levels
timeFrame: detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.
measure: The troponin I levels
timeFrame: detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.
measure: The left ventricle wall and cavity dimensions
timeFrame: detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.
measure: The left ventricle mass
timeFrame: detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.
measure: The left ventricle ejection fraction
timeFrame: detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.
measure: The left ventricle diastolic functions
timeFrame: detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge.
Other outcomes:
Locations:
city: Wufeng
country: Taiwan
facility: Asia University Hospital
state: Taichung
Study officials:
affiliation: China Medical University Hospital/Asia University Hospital
name: LI-Wei Chou, PhD
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Huang YC, Tsai HH, Fu TC, Hsu CC, Wang JS. High-Intensity Interval Training Improves Left Ventricular Contractile Function. Med Sci Sports Exerc. 2019 Jul;51(7):1420-1428. doi: 10.1249/MSS.0000000000001931.