Clinical trial NCT05206669: Testing Messages to Promote HPV Vaccination
Official title: TESTING MESSAGES TO PROMOTE USE OF AN HPV ONLINE INTERVENTION
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Behavior, Information Seeking
Intention
Vaccine Hesitancy
Keywords: HPV vaccine
Vaccine intention
Lead sponsor: University of Colorado, Denver
Sponsor class: OTHER
First posted: 2022-01-25
Enrollment: 784
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Intervention model description: The current study employed a 2 x 3 mixed factorial design. Participants consisted of two groups: 1) Hispanic or Latino parents of adolescents (age 11-17), and 2) Hispanic or Latino young adults (age 18-26). Participants were randomly assigned to one of three message conditions: cancer, genital warts, or control messages.
Primary purpose: PREVENTION

Brief summary: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Hispanic women have the highest rates of HPV-related cervical cancer compared to all other groups in the U.S. Previous research has delineated several unique barriers to HPV vaccination among Hispanic women, suggesting that interventions that focus on addressing these barriers may improve HPV vaccination compliance in this population. To address some of these unique barriers, an online tailored messaging intervention was developed and tested. Initial analyses demonstrate that participants exposed to an online intervention demonstrated higher intentions to vaccinate for HPV after viewing the informational materials. The next phase of the project will be comprised of promoting use of the online intervention to the general public through the use of theory-based, pretested messages delivered via advertisements on Facebook and Twitter. Specifically, messages will be targeted based on differences between Hispanic parents of adolescents and Hispanic young adults. Previous research has explored the use of the Extended Parallel Processing Model as a theory to guide messages designed to promote health behaviors. The current study extends this work in the area of HPV prevention. Specifically, it seeks to examine the use of this theory as a means to stimulate information seeking behavior in the form of use of the previously developed online intervention that provides information about HPV. We also hope to make a significant contribution to research demonstrating the importance of targeting messages based on differences in population characteristics. Additionally, this study seeks to build on research examining the use of social media sites as a means for implementing health interventions and promoting positive health outcomes. Ultimately, the current study seeks to improve both the HPV vaccination decision-making process and HPV vaccination rates. If this was achieved among the Hispanic population it could substantially decrease disparities in cervical cancer and other HPV-related diseases.


Eligibility criteria: Inclusion Criteria:

* For parents eligibility criteria were being: 1) of Hispanic or Latino origin, 2) 18 years or older, 3) a parent or guardian of a child ages 11-17 who had not been vaccinated for HPV.
* For young adults eligibility were being: 1) of Hispanic or Latino origin, 2) 18-26 years of age (vaccine eligibility at the time of data collection, and 3) having not been vaccinated for HPV.

Exclusion Criteria:

* Being under 18 years of age
* Not identifying as Hispanic or Latino
* For parents, having no children ages 11-17 or having only children already vaccinated for HPV
* For young adults, having already been vaccinated for HPV or no longer being eligible due to age (\>26)

Primary outcomes:
measure: Intention to Seek Information - 1
timeFrame: 1 day (one time while participants viewed the brief intervention.)
measure: Intention to Seek Information - 2
timeFrame: Outcome was measured one time immediately post-intervention via the post-survey items described to assess their degree of intention.
Secondary outcomes:
measure: Intention to Vaccinate for HPV
timeFrame: Outcome was measured one time immediately post-intervention via the post-survey items described to assess their degree of intention
Other outcomes:
Locations:
Study officials:
References:
citation: Reno JE, Dempsey AF. Promoting HPV vaccination among Latinx: an application of the extended parallel processing model. J Behav Med. 2023 Apr;46(1-2):324-334. doi: 10.1007/s10865-022-00293-7. Epub 2022 Feb 18.