Clinical trial NCT02160379: Effects of Roux-en-Y Gastric Bypass on Gastro-intestinal Hormone Secretion and Brain Responses Food Pictures
Official title: Dynamic Effect of Gastrointestinal Hormones on Cerebral Mechanisms Involved in Brain Perception of Food Pictures After Bariatric Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Keywords: roux-en-Y-gastric bypass
brain responses to food
gastrointestinal hormones
bile acids
Lead sponsor: University of Lausanne
Sponsor class: OTHER
First posted: 2014-06-10
Enrollment: 31
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Formerly obese patients attending the obesity clinics of Lausanne University Hospital and healthy subjects resident in the Lausanne area

Brief summary: This is a cross-sectional study enrolling

* 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB)
* 11 age- and weight-matched female subjects
* 10 normal weight (Body Mass Index 19-25 kg/m2) subjects The following measurements will be performed in each participants in basal conditions (after an overnight fast) and after ingestion of a standard meal
* electroencephalographic recordings of visually evoked potential after presentation of food- or non-food pictures
* plasma concentration of metabolites (glucose, fatty acids), glucoregulatory hormones (insulin, glucagon), gastro-intestinal hormones (Gastric Inhibitory Polypeptide (GIP), Glucagon-like Peptide-1 (GLP1), ghrelin,Cholecystokinin (CCK), and bile acids Aims of this observational study are
* to evaluate the effects of RYGB on brain perception of food related visual stimulation
* to search for relationships between RYGB effects on brain responses and gastro-intestinal hormone secretion


Eligibility criteria: Inclusion Criteria:

* good apparent health
* gender: female
* age 18-50
* non-smoker

Exclusion Criteria:

* diabetes or antidiabetic medication
* consumption of more than 50g alcohol per week
* vegetarian or any special diet

Primary outcomes:
measure: Changes of visually-evoked EEG potentials after ingestion of a meal
timeFrame: basal, 120 min postprandial and 240 postprandial
Secondary outcomes:
measure: changes in plasma triglyceride concentration after ingestion of a meal
timeFrame: basal, 90 min postprandial and 180 postprandial
measure: Changes in plasma glucoincretins (GLP1 and GIP) concentrations after ingestion of a meal
timeFrame: basal, 90 min postprandial and 180 postprandial
measure: Changes in plasma cholecystokinin concentrations after ingestion of a meal
timeFrame: basal, 90 min postprandial and 180 postprandial
measure: Changes in plasma bile acids concentrations after ingestion of a meal
timeFrame: basal, 90 min postprandial and 180 postprandial
measure: changes in plasma glucoregulatory status after ingestion of a meal
timeFrame: basal, 90 min postprandial and 180 postprandial
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: CHUV-clinical research center
state: VD
Study officials:
affiliation: University of Lausanne
name: Luc Tappy, MD
role: PRINCIPAL_INVESTIGATOR
References: