louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00343603: Tracking Optical Coherence Tomography
Official title: Tracking Optical Coherence Tomography
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Macular Degeneration
Glaucoma
Diabetic Retinopathy
Choroidal Disease
Keywords: maculopathy
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
Collaborators: name: National Eye Institute (NEI)
First posted: 2006-06-23
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subject can range between 18 to 85 years old. They can be healthy or diseased. Recruiting males and females.

Brief summary: The purpose of this research study is to evaluate an investigational system that may allow doctors to show images of the different parts inside the eye that show greater detail than current equipment can produce.

Detailed description: The purpose of this research study is to evaluate an investigational system that may allow doctors to make images of the parts inside the eye that show greater detail than current equipment can produce.

Eligibility criteria: Inclusion Criteria:

* Healthy individuals (this includes women of child-bearing potential) who are familiar with vision experiments and ophthalmic equipment, all over 18 years.
* Subjects will have a retinal screening if they are over 50 years old or have a known risk factor for eye disease, such as family history of age related macular degeneration or cardiovascular disease.
* Patients with retinal and choroidal disease: age related maculopathy or age related macular degeneration, diabetic retinopathy, glaucoma.

Exclusion Criteria:

* Over 85 years old

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: University of Pittsburgh
state: Pennsylvania
Study officials:
affiliation: University of Pittsburgh
name: Gadi Wollstein, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01521403: Is it Effective to Treat Patients With Blastocystis Hominis Infection?
Official title: Is it Effective to Treat Patients With Blastocystis Hominis Infection? A Double-blind Placebo Controlled Randomized Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Blastocystis Hominis Infections
Keywords: Blastocystis hominis
Metronidazole
Lead sponsor: University of Lausanne Hospitals
Sponsor class: OTHER
First posted: 2012-01-30
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The objective of this study is to determine whether in the setting of primary health care it is effective to treat with metronidazole returning travellers with gastrointestinal symptoms and B. hominis in the stool or not.

Detailed description: Prevalence of B. hominis is between 30-50% in developing countries. Many travellers visit developing countries and are therefore at risk to be infected by this parasite. It's frequent that travellers return from developing countries with gastro-intestinal symptoms and approximately 10% of them have B. hominis as the sole parasite identified in the stools. Some anti-infective drugs, including metronidazole, trimethoprim-sulfamethoxazole and nitazoxanide, have shown to have activity against B. hominis, but there is still controversy about the pathogenic potential of B. hominis and there is no consensus about the indications for treatment.

It is hypothesised that metronidazole is more effective than placebo in returning travellers with gastrointestinal symptoms and B. hominis as the sole intestinal parasite identified in the stool.

Eligibility criteria: Inclusion Criteria:

* ≥ 18 years
* Gastrointestinal symptoms for more than 10 days
* B. hominis in any quantity in at least one stool specimen out of 3 examined
* No other pathogenic micro-organism identified

Exclusion Criteria:

* Fever \> 37.5°
* bloody diarrhoea
* weight loss \> 10% of usual body weight
* significant decrease of general condition
* oncological diseases
* immune deficiencies
* known chronic intestinal diseases
* use of anti-protozoan drugs in the last 2 weeks
* use of anti-coagulant treatment or antabuse
* pregnant and lactating women

Primary outcomes:
measure: Improvement of gastro-intestinal symptoms
timeFrame: 10-14 days after treatment with Metronidazol
Secondary outcomes:
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: Travel Clinic, Department of Ambulatory Care and Community Medicine, University Hospital of Lausanne, Switzerland
state: Vaud
Study officials:
affiliation: Travel Clinic, Department of Ambulatory Care and Community Medicine, University Hospital of Lausanne, Switzerland
name: Serge de Valliere, MD, MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04705103: Development of AI Model for Uveitis Progression and Prognosis
Official title: Development of Artificial Intelligence Prediction Model for Uveitis Progression and Prognosis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Uveitis
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2021-01-12
Enrollment: 450
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 1. Initial stage of uveitis: The first episode of uveitis without treatment;
2. Remission of uveitis: Uveitis caused by various reasons in the stable disease period of more than 3 months without treatment;
3. Relapse of uveitis: After discontinuation of uveitis treatment, the disease stabilized for more than 3 months.

Brief summary: Uveitis is a recurrent inflammation of the eye that can lead to vision loss with various and complicated etiologies. There are many difficulties in uveitis management due to the requirement of long-term monitoring and treatment. This study intends to establish a longitudinal cohort of uveitis patients to colloect multimodal clinical data including visual acuity, intraocular pressure, anterior segment photography, fundus photography, fluoroscopy and other ophthalmic examinations, and final diagnosis in order to use artificial intelligence and deep learning technology to extract ocular features, explore the association with the progression and prognosis of uveitis and finally establish a disease management model for uveitis.


Eligibility criteria: Inclusion Criteria:

* Participants who were diagnosed as uveitis, including the initial stage or relapse, or remission of uveitis.

Exclusion Criteria:

* Participants who cannnot cooperate with ocualr examination.

Primary outcomes:
measure: uveitis progression
timeFrame: up to 1 month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03051503: Efficacy of Transdermal Fentanyl Patches in Relief of Acute Postoperative Pain After Mastectomy
Official title: Efficacy of Transdermal Fentanyl Patches in Relief of Acute Postoperative Pain After Mastectomy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Breast Cancer Female
Lead sponsor: South Egypt Cancer Institute
Sponsor class: OTHER
First posted: 2017-02-13
Enrollment: 60
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: to determine the safety, efficacy and tolerability of transdermal fentanyl in patients undergoing mastectomy, as well as the postoperative consumption of analgesic.


Eligibility criteria: Inclusion Criteria:

* ASA I - II patients
* aged 30-60 years
* body weight ranged between 65-10kg

Exclusion Criteria:

* Patients with history of allergy to morphine
* chronic intake of analgesics or non-steroidal anti-inflammatory drug 24 h prior to surgery,
* there was a history of a psychiatric disorder patients weight was less then 50kg.
* impaired kidney function.

Primary outcomes:
measure: Total dose of morphine consumption in the first 48 hours postoperative
timeFrame: 48 hours
measure: Visual Analogue Scale
timeFrame: 48 hours
Secondary outcomes:
measure: Level of stress hormones
timeFrame: 48 hours
measure: Side effects related to the opioids
timeFrame: 48 hours
Other outcomes:
Locations:
city: Assuit
country: Egypt
facility: South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Study officials:
affiliation: Cancer Institute, Anesthesia, Intensive Care, and Pain Management, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
name: Ahmed H Othman, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01707303: Effect Of Acute Inflammatory Mediators On Functional Limitations In Patients With Acute Respiratory Failure
Official title: Effect Of Acute Inflammatory Mediators On Duration Of Functional Limitations In Patients With Acute Respiratory Failure, A Randomized, Controlled Pilot Study of Early ICU Rehabilitation Strategies
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acute Respiratory Failure
Keywords: ICU
Critical Care
Intensive Care
Critical Illness
Acute Respiratory Failure
Mechanical Ventilation
Physical Therapy
Strength
Functional Status
Short Physical Performance Battery
Lead sponsor: Wake Forest University Health Sciences
Sponsor class: OTHER
First posted: 2012-10-16
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a randomized, controlled, pilot study of two separate Cohorts of patients from the intensive care unit. Cohort I will enroll 50 patients and randomize to receive one physical therapy session per day or receive usual ICU care. Cohort II, will enroll an additional 50 patients and randomize to receive either two physical therapy sessions per day or usual care. Outcome will be length of hospital stay measured in days. Secondary outcomes will be mortality, ventilator days, ICU days, and for Cohort II, grip strength, dynamometer strength assessments and the short physical performance battery (SPPB). Study subjects will have blood for cytokine analysis through their first week of study.


Eligibility criteria: Inclusion Criteria:

• Mechanically ventilated via an endotracheal tube or mask

Exclusion Criteria:

* Inability to walk without assistance prior to acute ICU illness (use of a cane or walkers not exclusions)
* Cognitive impairment prior to acute ICU illness (non-verbal)
* Preadmit immunocompromised (\>prednisone 20 mg/d for 2 wks)
* Acute stroke
* Body mass index (BMI) \>45
* Neuromuscular disease that could impair weaning (myasthenia gravis, ALS, Guillain-Barre)
* Hip fracture, unstable cervical spine or pathological fracture
* Mech vent \>48 hours prior to transfer from an outside facility
* Current hospitalization or transferring hospital stay \>72 hours
* CPR on admission, DNR on admission
* Hospitalization within 30 days prior to admission
* Cancer therapy within last 6 months
* Re-admission to ICU within current hospitalization

Primary outcomes:
measure: Hospital length of stay, days
timeFrame: The participants will be followed for the duration of the hospitalization, an expected average of 3 weeks.
Secondary outcomes:
Other outcomes:
Locations:
city: Winston-Salem
country: United States
facility: Wake Forest School of Medicine
state: North Carolina
Study officials:
affiliation: Wake Forest University Health Sciences
name: Peter E. Morris, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06079203: ED-LEAD: Emergency Departments Leading the Transformation of Alzheimer's and Dementia Care
Official title: ED-LEAD: Emergency Departments Leading the Transformation of Alzheimer's and Dementia Care
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Alzheimer's Disease Related Dementia
Alzheimer Disease
Keywords: Dementia
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2023-10-12
Enrollment: 19200
Sex: ALL
Minimum age (years): 66
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study is to improve the care of persons living with dementia (PLWD) and their informal care partners by addressing emergency and post-emergency care through different combinations of three PLWD-care partner dyad focused interventions. The primary aims are to use coaching to help connect PLWD and their care partners with community support and services to improve transitional care, quality of care, care satisfaction and reduce future ED visits and hospitalizations.


Eligibility criteria: Inclusion Criteria:

* patients age 66 and older
* have two or more ICD-10 visit diagnoses (one of which must be ambulatory) for Alzheimer's Disease or Alzheimer's Disease Related Dementias (AD/ADRD)
* care partners age 18 and older

Exclusion Criteria:

* patients who are under 66 years old

Primary outcomes:
measure: Number of Emergency Department (ED) revisits
timeFrame: Up to 30 days
Secondary outcomes:
measure: Number of ED revisits
timeFrame: Up to 14 days
measure: Number of ED revisits
timeFrame: Up to 6 months
measure: Number of hospitalizations
timeFrame: Up to 14 days
measure: Number of hospitalizations
timeFrame: Up to 30 days
measure: Number of hospitalizations
timeFrame: Up to 6 months
measure: Number of healthy days at home
timeFrame: Up to 6 months
Other outcomes:
Locations:
city: New York
country: United States
facility: NYU Langone Health
state: New York
Study officials:
affiliation: NYU Langone Health
name: Joshua Chodosh, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04230603: Tissue Characterization With Hyperspectral Imaging (HSI)
Official title: Tissue Characterisation With Hyperspectral Imaging Methods
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Tissue Perfusion
Tumor
Inflammation
Inflammatory Bowel Diseases
Keywords: hyperspectral imaging
tissue detection
tumor detection
infammatory bowel disease
colorectal cancer
Lead sponsor: University of Leipzig
Sponsor class: OTHER
First posted: 2020-01-18
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Hyperspectral Imaging (HSI) is a contact free method to analyse the from the tissue reflected light in the range of 500-1000nm. Aim of the study is to identify special reflex patterns to identify special tissue

Detailed description: This HSI-camera provides hyperspectral images with a high spectral resolution (5 nm) in the visible and near infrared range (500-1000 nm). A RGB image and 4 false color images that represent physiologic parameters are intraoperatively provided by an analysis software. But after the procedure all spectral datasets could be investigated. To analyse and differentiate the different tissues, a catalog database is needed of all tissues including Tumors.

Eligibility criteria: Inclusion Criteria:

* All patients with surgical procedure

Exclusion Criteria:

* inability to consent

Primary outcomes:
measure: Tumor detection with HSI
timeFrame: direct during the Operation (ca. 15-20 Minutes)
measure: Tissue recognition with HSI
timeFrame: after the operation within 24 hours
measure: Inflammatory classification with HSI
timeFrame: after the operation within 24 hours
Secondary outcomes:
measure: Tissue perfusion
timeFrame: direct during the Operation (ca. 10-15 Minutes)
Other outcomes:
Locations:
city: Leipzig
country: Germany
facility: Universitätsklinikum Leipzig - AöR
state: Sachsen
Study officials:
affiliation: University of Leipzig
name: Ines Gockel, MD, Prof.
role: STUDY_DIRECTOR
References:
Clinical trial NCT02254603: The Effects of the Combined Therapy of Acupuncture and Yoga Exercise on Weight Loss
Official title: To Evaluate the Effects of Weight-loss by the Combined Therapy of Acupuncture and Yoga Exercise
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Obesity
Keywords: Obesity, ayuveda yoga exercise, acupuncture.
Lead sponsor: Chang Bing Show Chwan Memorial Hospital
Sponsor class: OTHER
First posted: 2014-10-02
Enrollment: 74
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of this study is to examine the effects of combination of acupuncture and ayuveda yoga exercise on weight loss for the overweight.

Detailed description: Obesity is a common health problem in developed countries. At present,the medical staff have already been alerted that the obesity is a kind of disease actually and one of the epidemic diseases which erode the human health in the world. It is not only about the person's health but also a main public health problem. It has been caught to our attention that some diseases, such as cardiovascular diseases,diabetes, and high blood pressure are coming along with overweight and obesity. Recent studies had demonstrated a positive correlation between chronic diseases and obesity. There are many treatments for the obesity, in general, acupuncture may be an effective one. Acupuncture may suppress the people's appetite, slow down the stomach's creeping motion, and increase the stomach's evacuation time. Simultaneously, acupuncture controls the body through the absorption and storage of the calorie via the adjustment of the endocrine system. But we still need a more efficiency way to accelerate the body fat metabolism and decrease the storage of the fat in vivo. Therefore, the purpose of this study is to examine the effects of combination of acupuncture and ayuveda yoga exercise on weight loss among the overweight.

Eligibility criteria: Inclusion Criteria:

* BMI \> 24

Exclusion Criteria:

* Diagnosis of cancer.

Primary outcomes:
measure: Reduce body mass index.
timeFrame: Change from baseline in body mass index at 3 months
Secondary outcomes:
measure: Reduce waistline
timeFrame: Change from baseline in waistline at 3 months
measure: Change biochemical profile of blood
timeFrame: Change from baseline in biochemical profile of blood at 3 months
measure: Immune modulation
timeFrame: Change from baseline in lymphocyte profile and polarization at 3 months
Other outcomes:
Locations:
city: Changhua County
country: Taiwan
facility: Division of Core Laboratory; Chang Bing Show Chwan Memorial Hospital
Study officials:
affiliation: Chang Bing Show Chwan Memorial Hospital
name: Kuender D. Yang, PhD.
role: STUDY_CHAIR
affiliation: Chang Bing Show Chwan Memorial Hospital & Central Taiwan University of Science and Technology
name: Shu-Hui Yeh, PhD.
role: STUDY_DIRECTOR
affiliation: Show Chwan Memorial Hospital
name: Yu-Kwan Lu, MD.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03966703: Masticatory Efficiency in Implant-fixed Complete Dentures Compared to the Conventional Dentures
Official title: Masticatory Efficiency in Implant-fixed Complete Dentures Compared to the Conventional Dentures: a Randomized Clinical Trial by Color Mixing Analysis Test.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mastication
Keywords: complete denture
implant-fixed denture
masticatory efficiency
mixing ability test
Lead sponsor: St Joseph University, Beirut, Lebanon
Sponsor class: OTHER
First posted: 2019-05-29
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: 10 patients from each group
Primary purpose: DIAGNOSTIC

Brief summary: Purpose of this study is to compare the masticatory efficiency 'All on four' to 'Complete dentures on a class I ridge' with a color mixing analyzing test. Ten Patients with fixed complete dentures on implants and other ten patients with complete denture on a class I ridge (Atwood) had chewed a bicolor chewing gum (Hubba Bubba ®) for different number of cycles(5-10-15-20). The chewed gum is retrieved scanned and weighted to quantify masticatory efficiency


Eligibility criteria: Inclusion Criteria:

* good general health, good intraoral conditions, and dentures in satisfactory conditions over edentulous high ridge Atwood's Class I. The minimum time of complete denture use ranged from 3 to 6 months. no temporomandibular dysfunction

Exclusion Criteria:

-

Primary outcomes:
measure: color analysis mixing test
timeFrame: from 5 up to 20 second
Secondary outcomes:
measure: weight reduction
timeFrame: from 5 up to 20 second
Other outcomes:
Locations:
city: Beirut
country: Lebanon
facility: Saint Joseph University
Study officials:
affiliation: Master student in aesthetic and prosthetic dentistry
name: Elie Jasser, DSD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04993703: Effect of Kinesiotaping and Night Splinting in Patients With Carpal Tunnel Syndome
Official title: Comparison of Short-term Effect of the Kinesiotaping and Night Splinting in Patients With Carpal Tunnel Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Carpal Tunnel Syndrome
Keywords: carpal tunnel syndrome
night splinting
kinesiotaping
physiotherapy and rehabilitation
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2021-08-06
Enrollment: 45
Sex: ALL
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Carpal tunnel syndrome (CTS) which is defined as a symptomatic compression neuropathy of the median nerve at the level of the wrist.

Different types of splints are used for improving the function and decreasing the pain intensity and symptoms in the rehabilitation of patients with CTS.

However effectiveness of treatment by taping has never been investigated in physiotherapy and rehabilitation.

The aim of this study was to compare the short-term effect of conventional physiotherapy only, and also kinesio taping and night splinting in patients with CTS.

Detailed description: Carpal tunnel syndrome (CTS) which is defined as a symptomatic compression neuropathy of the median nerve at the level of the wrist.It is considered as the most common disabling neuromuscular condition of the upper extremities.

Night splints are used in conjunction with the conservative intervention to improve the function and decrease the pain intensity and paresthesia in the rehabilitation of patients with carpal tunnel syndrome. However effectiveness of treatment by kinesiotaping has never been investigated.

The aim of this study was to compare the short-term effect of conventional physiotherapy only, and also kinesio taping and night splinting in addition to conventional physiotherapy in the rehabilitation of patients with CTS.

Eligibility criteria: Inclusion Criteria:

* This study included patients with moderate CTS, confirmed by electroneurographic examination.
* did not recruit any treatment (including physiotherapy or surgical release)

Exclusion Criteria:

* Patients suffer from the thenar muscle atrophy.
* Patients with mild CTS.

Primary outcomes:
measure: functional impairment
timeFrame: functional impairment will be recorded at baseline and 4-week follow-up
Secondary outcomes:
measure: pain intensity
timeFrame: change from baseline to 4-week follow-up will be recorded
measure: paresthesia
timeFrame: change from baseline to 4-week follow-up will be recorded
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University, Faculty of Physical Therapy and Rehabilitation
Study officials:
References: