Clinical trial NCT01408602: A Study of Two Doses of MRC375 in Moderate to Severe Rheumatoid Arthritis Patients
Official title: A 24-week, Phase 2, Double-blind, Placebo-controlled, Randomized Study to Assess the Safety and Efficacy of 2 Doses of MRC375 in Patients With Moderate to Severe Rheumatoid Arthritis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Rheumatoid Arthritis
Keywords: Rheumatoid Arthritis
Lead sponsor: Molecular Research Center, Inc.
Sponsor class: INDUSTRY
Collaborators: name: Camargo Pharmaceutical Services
name: Clin Data Services
name: Harrison Clinical Research
name: BARC Global Central Laboratory
name: Bilcare Global Clinical Supplies
First posted: 2011-08-03
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will treat moderate to severe rheumatoid arthritis with MRC375 (either 75 mg 3 times a day, 150 mg 3 times a day or placebo 3 times a day)in patients 18 years of age or older that can be currently on low doses of methotrexate or can stop treatment of current RA medications to enter the study. Safety of MRC375 will also be evaluated. There are up to 8 clinic visits over 24 weeks.

Detailed description: This is a double-blind, randomized, placebo-controlled study to assess the safety and efficacy of MRC375 at 75 mg or 150 mg with matching placebo (taken tid with meal or light snack) in patients with moderate to severe RA. Patients will be randomized to one of the following study arms for 24 weeks:

* Treatment 1, Placebo: 2 tablets taken tid
* Treatment 2, MRC375: 1 tablet of 75 mg tetracycline HCL plus 1 matching placebo tablet taken tid. Total daily dose = 225 mg.
* Treatment 3, MRC375: 2 tablets of 75 mg tetracycline HCL taken tid. Total daily dose = 450 mg.

Study medication should be taken within 30 minutes of a meal or light snack (either before or after).

Eligibility criteria: Inclusion Criteria:

1. Is 18 years of age
2. Is diagnosed with moderate to severe adult onset RA \> = 6 months duration, as defined by the 1987 ACR classification criteria
3. Has moderate to severe RA as defined by:

   * ≥4 tender joints/painful (28 joint count) at screening
   * ≥4 swollen joints (28 joint count) at screening
4. Has a Health Assessment Questionnaire (HAQ) of \>0
5. Has a physician global assessment (Likert scale) of \>0
6. Has a patient global assessment of pain (Likert scale) of \>0
7. Has a patient assessment of pain (Likert scale) of \>0
8. Has stable doses of the following allowable medications during the study, if applicable:

   * Stable dose of NSAIDs or other analgesics for at least 2 weeks prior to administration of study drug at regulatory approved doses
   * Stable dose of methotrexate 7.5 mg to 25 mg/day once weekly for at least 6 weeks prior to administration of study drug (no changes in dosing regimen for 4 weeks prior to screening)
   * Stable dose of hydroxychloroquine either monotherapy or in combination with methotrexate 8 weeks prior to administration of study drug
9. Is a non-pregnant, non-lactating female who is postmenopausal, naturally or surgically sterile, or who agree to use effective contraceptive methods throughout the course of the study. Postmenopausal is defined as at least 12 months natural spontaneous amenorrhea
10. If female of childbearing potential, must agree to use one of the following acceptable birth control methods:

    * Surgically sterile (bilateral tubal ligation with surgery at least 6 weeks prior to screening, hysterectomy, or bilateral oophorectomy);
    * Intrauterine device (IUD) in place for at least 3 months prior to first dose of study drug;
    * Abstinence (not having sexual intercourse);
    * Barrier method (condom or diaphragm) with spermicide for at least 14 days prior to screening and through study completion;
    * Stable hormonal contraceptive for at least 3 months prior to study and through study completion
11. If female of childbearing potential, has a negative serum hCG pregnancy test at screening
12. Is able to swallow whole tablets of orally administered medication
13. Is able to understand and provide signed informed consent.

Exclusion Criteria:

1. Has been diagnosed with any other inflammatory arthritis (eg, psoriatic arthritis)
2. Has a secondary type of arthritis (eg, osteoarthritis) that would interfere with study evaluations
3. Has taken the following drugs within the timeframe specified below:

   * Infliximab, etanercept, adalimumab, abatacept, or other biological therapies (except rituximab) - Within 12 weeks prior to the administration of study drug;
   * Rituximab - Within 12 months prior to the administration of study drug;
   * Disease-modifying antirheumatic drugs (DMARDs) or other anti-rheumatic therapies not specified above including but not limited to: sulfasalazine, gold, leflunomide, penicillamine, dapsone, azathioprine, 6-mercaptopurine, chlorambucil, cyclophosphamide, cyclosporin, mycophenolate mofetil - Within 12 weeks prior to the administration of study drug;
   * Any steroids (glucocorticoids); glucocorticoids must be discontinued for at least 4 weeks prior to administration of study drug. Intraarticular, intramuscular, or intravenous glucocorticoids must not have been given at least 6 weeks prior to administration of study drug.
   * Note: Use of probiotics is allowed and is NOT an exclusion criterion.
4. Has a uncontrolled symptoms of fibromyalgia with sufficient symptoms requiring treatment (NOTE: patients on a stable dose of treatment for symptoms of fibromyalgia ≥ 4 weeks will be allowed in the study.)
5. Has a history of allergic reaction to tetracycline or other related drugs
6. Had major surgery or trauma within 28 days prior to screening
7. Is concurrently using minocycline or doxycycline (washout of 4 weeks required before the administration of study drug)
8. Patients who are on chronic antibiotics or who are on antibiotics for GI infections (such as Clostridium difficile)
9. Has clinically significant ECG abnormalities
10. Has any clinically significant abnormal laboratory test results found during medical screening including: AST or ALT \> 2 x upper limit of normal or serum creatinine \> 2.0 mg/dL
11. Has clinically significant history or presence of any gastrointestinal pathology (eg, chronic diarrhea, inflammatory bowel disease, acute diverticulitis), irritable bowel syndrome, unresolved gastrointestinal symptoms (eg. diarrhea, vomiting, symptoms of acute diverticulitis), liver or kidney disease, gastric bypass, gastric stapling, use of Lap-Band®, or other conditions known to or which might interfere with the absorption, distribution, metabolism, or excretion of the drug
12. Has any historical or active neurological, endocrine, cardiovascular, pulmonary, hematological, psychiatric, or metabolic disease that is considered clinically significant by the Investigator
13. Has known history of HIV, hepatitis B or C (patients that have positive hepatitis B serology due to prior vaccination will be allowed in the study)
14. Has an active malignancy of any type or history of malignancy. Patients who have a history of a successfully treated non-metastatic cutaneous squamous cell or basal cell carcinoma (ie. non melanoma skin cancer)and/or localized carcinoma in situ of the cervix are eligible. Patients with a history of other malignancies that have been treated and who have no evidence of recurrence for at least 5 years before study enrollment are also eligible.
15. Has difficulty swallowing tablets
16. Is ACR Functional Class IV (limited ability to perform usual self-care, vocational, and avocational activities)
17. Has known or suspected pregnancy, planned pregnancy, or lactation (for female patients)
18. Has clinically significant mental illness (to be determined by the Investigator)
19. Has a history in the last 2 years or current evidence of abuse of illicit drugs, prescription medications, or alcohol that, in the opinion of the Investigator, would interfere with adherence to study requirements. Has exposure to any investigational agent within 30 days prior to study entry.
20. Was previously enrolled in this study
21. Has recent history of bacterial intestinal tract infection (gastroenteritis, colitis, diverticulitis, appendicitis)
22. Has a condition the Investigator believes would interfere with the ability to provide informed consent or comply with study instructions, or that might confound the interpretation of the study results or put the patient at undue risk

Primary outcomes:
measure: Efficacy evaluated of both doses of MRC375 compared to placebo after 24 weeks of treatment as measured by the rate of achievement of 20% improvement in ACR criteria
timeFrame: 24 weeks
Secondary outcomes:
measure: Safety and tolerability of both doses of MRC375
timeFrame: 24 weeks
measure: Compare the Efficacy of two doses of MRC375 when compared to a placebo for the change from baseline screening in each of the individual ACR components measuring RA after 24 weeks of treatment
timeFrame: 24 weeks
Other outcomes:
Locations:
city: Mobile
country: United States
facility: Mobile Diagnostic Center Rheumatology
state: Alabama
city: Long Beach
country: United States
facility: Valerius Medical Group
state: California
city: Los Alamitos
country: United States
facility: Trial Concierge/Pacific Clinical Studies
state: California
city: Los Angeles
country: United States
facility: Axis Clinical Trials
state: California
city: Edgewater
country: United States
facility: Riverside Clinical Research
state: Florida
city: Miami
country: United States
facility: Global Clinical Professionals
state: Florida
city: Palm Harbor
country: United States
facility: The Arthritis Center
state: Florida
city: Summerfield
country: United States
facility: Lakeview Medical Research
state: Florida
city: Lenexa
country: United States
facility: Analan Clinical Research
state: Kansas
city: Owensboro
country: United States
facility: Trial Concierge
state: Kentucky
city: Omaha
country: United States
facility: Quality Clinical Research, Inc.
state: Nebraska
city: Las Vegas
country: United States
facility: Advanced BioMedical Research of America
state: Nevada
city: Reno
country: United States
facility: Arthritis Center of Reno
state: Nevada
city: Salisbury
country: United States
facility: PMG Research of Salisbury
state: North Carolina
city: Dayton
country: United States
facility: Providence Health Partners
state: Ohio
city: Middleburg Heights
country: United States
facility: Paramount Medical Research & Consulting, LLC
state: Ohio
city: Williamsburg
country: United States
facility: The Center for Excellence in Aging and Geriatric Health
state: Virginia
city: Kennewick
country: United States
facility: Apex Clinical Research
state: Washington
city: Olympia
country: United States
facility: South Puget Sound Clinical Research Center
state: Washington
Study officials:
References: