Clinical trial NCT06958523: Apple Health Study
Official title: Apple Health Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Mental Health
Sleep
Exercise
Hormones
Metabolic Health
Hearing
Aging
Lifestyle Factors
Functional Capacity
Neurological Conditions
General Health
Wellbeing
Women&#39;s Health
Keywords: Apple Health Study
Large Scale Digital Study
Digital Biomarkers
Research App
Apple Research App
iPhone
Lead sponsor: Apple Inc.
Sponsor class: INDUSTRY
Collaborators: name: Brigham and Women's Hospital
name: MCRA
First posted: 2025-05-06
Enrollment: 500000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The Study aims to enroll a large and representative group of at least 500,000 participants across the United States of America willing to contribute information about health and wellness over time.

Brief summary: This Study aims to build a diverse and inclusive group of participants to help researchers advance our understanding of how signals and information collected from apps and devices relate to health and may be used to predict, detect, monitor, and manage changes in health.

Participants will be asked to complete tasks and surveys, using their iPhone and Apple Research app which include:

* Selecting the types of data they would like to share with the study such as health and sensor data
* Complete tasks and surveys including areas such as personal demographic information, personal medical history, family history, and social determinants of health


Eligibility criteria: Inclusion Criteria:

* Be at least 18 years old (at least 19 years old in Alabama and Nebraska, at least 21 years old in Puerto Rico);
* Live in the United States of America;
* Have an iPhone;
* Have installed Apple Research app on your iPhone;
* Be comfortable communicating in written and spoken English;
* Be willing and able to provide informed consent to participate in the Study.

Exclusion Criteria:

* Share your iCloud account, iPhone, or devices that collect health data such as Apple Watch with anyone else, because it could result in sharing another person's health information with the Study, making it challenging for researchers to use your information.

Primary outcomes:
measure: Health Status
timeFrame: Baseline and every 6 months until study end (up to 5 years)
Secondary outcomes:
measure: Participant Population: Demographic Characteristics of Study Participants
timeFrame: Baseline and annually until study end (up to 5 years)
measure: Social Determinants of Health: Lifestyle & Environment Survey
timeFrame: Baseline and every 6 months until study end (up to 5 years)
measure: Family Health History in Health Conditions and Health Events
timeFrame: Baseline and have option to update if needed (up to 5 years)
Other outcomes:
Locations:
city: Washington
country: United States
facility: MCRA
state: District of Columbia
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
Study officials:
affiliation: Brigham and Women's Hospital
name: Calum MacRae, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: MCRA
name: Tiffany Avery, MD
role: PRINCIPAL_INVESTIGATOR
References: