louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06942702: Efficacy of Genicular Block on Total Knee Arthroplasty Surgery
Official title: Assesment of Postoperative Analgesic Efficacy of Preoperatively Applied Genicular Block on Total Knee Arthroplasty: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Total Knee Anthroplasty
Genicular Nerves Block
Keywords: total knee arthroplasty
genicular block
postoperative pain
Lead sponsor: Mersin University
Sponsor class: OTHER
First posted: 2025-04-24
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aim of this study is to investigate the postoperative pain relieving effect of preoperative genicular block in total knee arthroplasty surgery. The main questions it aims to answer are:

1. Do visual analog scale (VAS) scores decrease in patients who underwent geniculate block?
2. Does opioid consumption decrease in patients who underwent geniculate block?

Researchers will compare postoperative pain in patients who received genicular block with those who did not.One group of patients will be administered 0.25% bupivacaine with the geniculate block method. The other group will not undergo any intervention. Both groups will be administered intravenous morphine for postoperative analgesia.

Detailed description: Patients scheduled for knee arthroplasty will be randomly assigned into two groups. One group will receive a genicular nerve block prior to surgery without the administration of general anesthesia, while the other group will not undergo any interventional procedure. The genicular nerve block will be administered in three quadrants around the knee, with each injection consisting of 5 mL of 0.25% Marcaine. All injections will be performed by investigator MA. Patient assessments will be conducted by investigator MO. Postoperative intravenous analgesia will be provided to both groups.

Eligibility criteria: Inclusion Criteria:

* Scheduled for unilateral and primary total knee arthroplasty
* Older than 18 years of age

Exclusion Criteria:

* Younger than 18 years
* Bilateral knee arthroplasty
* Revision case of knee arthroplasty

Primary outcomes:
measure: Visual Analog Scale Measure
timeFrame: 0-48 hours
measure: opioid consumption
timeFrame: 0-48 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Mersin university Faculty of Medicine, Department of Anesthesiology and Reanimation
name: Mustafa Azizoglu, Associated Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wang T, Leng YF, Zhang Y, Kang YQ, Xue X, Zhang Y. [Preventive effects of ischemic postconditioning and penehyclidine hydrochloride on gastric against ischemia-reperfusion injury in rats]. Zhonghua Yi Xue Za Zhi. 2011 Apr 26;91(16):1130-5. Chinese.
Clinical trial NCT00263302: Diuretic Efficacy of Dexamethasone in Heart Failure
Official title: Diuretic Efficacy of Dexamethasone in Congestive Heart Failure Patients
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: PHASE1
Conditions: Heart Failure, Congestive
Keywords: dexamethasone, diuretic, congestive heart failure
Lead sponsor: Hebei Medical University
Sponsor class: OTHER
First posted: 2005-12-08
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether glucocorticoids have potent diuretic effects in patients with congestive heart failure.

Detailed description: Glucocorticoids are known to have pronounced physiological effects in the kidney. Conventional teaching dictates that it should be used with caution in patients with congestive heart failure due to its fluid and sodium retention effects. Surprisingly, despite the widespread prevalence of this belief within the medical community, there are few data to support it. In fact, several small animal studies have documented its striking diuretic effects due to increased renal plasma flow and glomerular filtration rate without changes in the glomerular filtration fraction. We design this study to determine whether glucocorticoids have a potent diuretic effect in patients with heart failure.

Eligibility criteria: Inclusion Criteria:

* Congestive heart failure patients due to any cause
* Patients with normal cortical function
* Congestive heart failure patients who are on diuretic therapy
* Clinically stable and body weight maintained the same for at least 3 days without signs of fluid retention

Exclusion Criteria:

* Patient refusal
* Signs of infection

Primary outcomes:
measure: urine volume
measure: urine electrolyte excretion (urine sodium, urine potassium, urine chloride), and urine creatinine.
measure: serum electrolyte (serum sodium, serum potassium, serum chloride), serum creatinine, serum urea, serum uric Acid.
measure: fractional sodium excretion
measure: glomerular filtration rate (calculated by Cockroft and Gault formula).
Secondary outcomes:
Other outcomes:
Locations:
city: Shijiazhuang
country: China
facility: Kunshen Liu
state: Hebei
city: Shijiazhuang
country: China
facility: The First Hospital of Hebei Medical University
state: Hebei
Study officials:
affiliation: Hebei Medical University
name: Kunshen Liu, M.D.
role: STUDY_CHAIR
References:
Clinical trial NCT00065702: Biomarkers of Homeopathy in Fibromyalgia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Fibromyalgia
Keywords: fibromyalgia
homeopathy
EEG
EKG
chronic pain
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH)
Sponsor class: NIH
First posted: 2003-08-01
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy of individualized classical homeopathy in treatment of persons with fibromyalgia and to determine the usefulness of electroencephalographic and electrocardiographic measures to serve as markers of differences between active and placebo treatment.


Eligibility criteria: Inclusion criteria:

* ACR diagnosis of fibromyalgia;
* Willing to take daily active or placebo liquid remedy under double blind conditions for 6 months, involving daily succussion and dilution of source liquid from a stock bottle;
* Willingness/ability to comply with dietary and lifestyle restrictions, i.e., no coffee in any form, no comphor or menthol-containing products; no electric blankets, no strong aromatics, no routine vaccinations, no concomitant use of acupuncture, chiropractic, polarity therapy, psychic healing, or magnet therapy;
* No dental drilling, MRI scans unless emergent;
* Withhold food or drink 30 mins before/after therapy;
* Stable conventional care for 2 months prior to entry;
* Willing to undergo 3 diagnostic physical exams, and to permit videotaping of interview sessions;
* Willing to fill out questionnaires

Exclusion criteria:

* Steroid-dependent medical conditions;
* Chronic benzodiazepine or anticonvulsant use;
* Use of tricyclic antidepressants, antihypertensives, and other drugs that alter orthostasis;
* Pregnancy;
* History of seizure disorder or syncope;
* Life-threatening medical conditions;
* Current active asthma;
* History of anaphylactic shock;
* Insulin-dependent diabetes;
* Active suicidal ideation or psychosis.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Tucson
country: United States
facility: U of Arizona College of Medicine, Program in Integrative Medicine
state: Arizona
Study officials:
affiliation: University of Arizona College of Medicine
name: Iris R. Bell, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02430402: Rehabilitation of Young Patients With Rheumatic Diseases in a Warm Climate
Official title: Effect of Rehabilitation of Young Patients With Rheumatic Diseases in a Warm Climate. A Pilot Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Rheumatic Diseases
Keywords: Climatotherapy
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
Collaborators: name: St. Olavs Hospital
First posted: 2015-04-30
Enrollment: 64
Sex: ALL
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Young patients with rheumatic diseases have challenges different from older patients due to their life situation. It has been reported that they do not have the same benefit from age non-specific rehabilitation in warm climate. This trial will test the effect of a specially adapted version of a rehabilitation program delivered in Spain (warm climate) for Norwegian young adults aged 20-35 years.


Eligibility criteria: Inclusion Criteria:

* Inflammatory rheumatic disease
* Self reliant in daily life

Exclusion Criteria:

- conditions that might influence ability to fly to Spain and participate in rehabilitation in warm climate (Unstable heart disease, Serious lung disease, Chronic open ulcers, Serious mental health conditions, alcohol or drug addiction, Intolerant of sun and heat)

Primary outcomes:
measure: Coping (Effective Consumer Scale (EC17)
timeFrame: 12 months
measure: 30 second sit to stand test
timeFrame: 12 months
Secondary outcomes:
measure: EQ5D
timeFrame: 12 months
measure: Numerical Rating Scales (NRS) fatigue question
timeFrame: 12 months
measure: Hannover functional Scale
timeFrame: 12 months
measure: Coop Wonca
timeFrame: 12 months
measure: Hopkins Symptom Checklist
timeFrame: 12 months
measure: Patient Specific Functional scale
timeFrame: 12 months
measure: Numerical Rating Scales (NRS) pain question
timeFrame: 12 months
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Institute for Social Medicine
Study officials:
affiliation: Norwegian University of Science and Technology
name: Aslak Steinsbekk, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Nilssen IR, Koksvik HS, Gronning K, Steinsbekk A. Rehabilitation in warm climate for young adults with inflammatory arthritis: A 12-month randomized controlled trial. J Rehabil Med. 2020 Apr 14;52(4):jrm00040. doi: 10.2340/16501977-2666.
Clinical trial NCT00524602: The Use of Remote Magnetic Navigation in Catheter Ablation of Heart Arrythmia
Official title: A Nonrandomized Observertionel Study That Will Show the Utility and the Safety by Using the Remote Magnetic Navigation of Ablationcatheters and the Stereotaxis Equipment
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Arrythmia
Keywords: Stereotaxis
Arrythmia
Catheter ablation
Heart
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
First posted: 2007-09-03
Enrollment: 2000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Patients with several heart arrythmia can potentially be cured by catheterablation. For some arrythmias 95% of the patients are cured. Also patients with atrial fibrillation are cured by catherablation even though the effect is not as impressive as for other cardiac arrythmias. About 70% of patients with paroxystic and persistant atrial fibrillation are cured. Most of the remaining obtain a reduction of their symptoms.

At conventional ablation of atrial fibrillation the catheters are manually navigated to the ideal anatomic position where to isolate the pulmonary veins from the left atrium.

Lately it has been possible to navigate the ablationcatheters using 'remote magnetic navigation' using a magnetic based navigation equipment, Stereotaxis.

The Heartcentre of Rigshospitalet had this Stereotaxis equipment installed in the autumn of 2006.

We will investigate the utility and safety of using this remote magnetic navigation/Stereotaxis.

Detailed description: The purpose on this study is to show the utility and the safety by using the remote magnetic navigation of ablation catheters with the Stereotaxis equipment at ablations of

* atrial fibrillation, atrial flutter and other arrythmias
* childrens arrythmias
* arrythmias of patients with pacemaker or ICD (Implantable Cardiac Defibrillator)

Eligibility criteria: Inclusion Criteria:following patients that need catheter ablation:

* Patients with atrial fibrillation
* Patients with artial flutter
* Patients with other tachy arrythmia
* Patients with paceaker/ICD

Exclusion Criteria:

* Patients with anamnestic psycosis or other conditions where information is impossible or insure to give
* Contraindication to magnetic ablation therapy

Primary outcomes:
measure: Clinical effect and safety of ablation
timeFrame: 3 month after procedure
Secondary outcomes:
measure: Feasibility of remote navigation
timeFrame: within 3 months
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Rigshospitalet
Study officials:
affiliation: Rigshospitalet, Denmark
name: Xu Chen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04371302: Nursing Perspective on Burnout and Medical Errors in the Intensive Care Unit During Covid-19 Pandemic
Official title: Nursing Perspective on Burnout and Medical Errors in the Intensive Care Unit of an Exclusively Covid-19 Hospital: the Malaysian Experience
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Burnout, Professional
Medical Errors
Depression
Keywords: Burnout
Depression
Medical errors
Intensive Care Unit nurses
Covid-19
Lead sponsor: University of Malaya
Sponsor class: OTHER
First posted: 2020-05-01
Enrollment: 145
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All ICU nurses serving in Sungai Buloh Hospital, a nationally designated exclusive Covid-19 hospital in Malaysia during the Covid-19 pandemic.

Brief summary: The investigators plan to perform an observational study to evaluate the prevalence of burnout, depression and medical errors in a designated exclusive Covid-19 patients hospital in Malaysia, during the Covid-19 pandemic. In addition, the relationship between burnout and depression with medical errors will be assessed. The population studied will be the nurses working in the Intensive Care Unit, who are at higher risk due to the nature of their work at the frontlines of the pandemic.

Detailed description: During this unprecedented Covid-19 pandemic crisis in the whole world, Malaysia is also affected, with more than 5000 patients infected in the whole country as of 20th April, 2020. Many Intensive Care Unit nurses, who are at the frontlines of managing Covid-19 patients, face increased workload, in addition to psychological stress from managing these patients, with stress also coming from being exposed to the risk of cross infection. Hence, they are possibly at high risk of burnout and depression. In such a time of increased stress, the investigators also seek to find out the prevalence of medical errors made by Intensive Care Unit nurses during this pandemic, and whether the medical errors are associated with burnout. Factors associated with burnout, depression and medical errors will also be evaluated.

Eligibility criteria: Inclusion criteria

1. All nurses currently serving in the ICU, Sungai Buloh Hospital

Exclusion criteria

1. Subjects who refuse to participate
2. Subjects working in ICU, Sungai Buloh Hospital, for less than 1 month

Primary outcomes:
measure: Prevalence of burnout among ICU nurses during Covid-19
timeFrame: 2 months
measure: Prevalence of depression among ICU nurses during Covid-19
timeFrame: 2 months
measure: Prevalence of self-perceived medical errors among ICU nurses during Covid-19
timeFrame: 2 months
measure: Association of burnout, depression and medical errors among anaesthesiology clinicians during Covid-19
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Kuala Lumpur
country: Malaysia
facility: Sungai Buloh Hospital
Study officials:
References:
Clinical trial NCT01803802: Effects of Early Abuse on Adult Intimate Relationships
Official title: Effects of Early Abuse on Adult Intimate Relationships
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypoactive Sexual Desire Disorder
Female Sexual Arousal Disorder
Female Orgasmic Disorder
Major Depressive Disorder
Post-traumatic Stress Disorder
Keywords: childhood sexual abuse
depression
PTSD
sexual function
women
Lead sponsor: University of Texas at Austin
Sponsor class: OTHER
Collaborators: name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
First posted: 2013-03-04
Enrollment: 148
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study is designed to help us better understand the factors that affect the sexual lives of women who have been sexually mistreated during childhood. With this study we hope to learn about factors that may be promising targets for future treatments of sexual problems related to past sexual experiences. The investigators hypothesize that women who have experienced early sexual abuse are more likely to have sexual problems in adulthood than women who were not abuse in childhood.


Eligibility criteria: Inclusion Criteria:

* at least one involuntary sexual experience, defined as "unwanted oral, anal, or vaginal intercourse, penetration of the vagina or anus using objects or digits, or genital touching or fondling," before age 16 and no less than 2 years prior to enrollment.
* currently sexually active or cohabiting in a potentially sexual relationship.
* current sexual dysfunction, distress, or low sexual satisfaction

Exclusion Criteria:

* traumatic event in the previous three months
* sexual abuse in the past two years
* diagnosis of a psychotic disorder in the previous six months
* significant suicidal or homicidal intent
* currently receiving psychotherapy for sexual or abuse-related concerns
* use of illicit drugs
* in a currently abusive relationship

Primary outcomes:
measure: Sexual Dysfunction Interview
timeFrame: 6 months
Secondary outcomes:
measure: Depression
timeFrame: 6 months
measure: Post-Traumatic Stress
timeFrame: 6 months
Other outcomes:
Locations:
city: Austin
country: United States
facility: University of Texas at Austin
state: Texas
Study officials:
References:
citation: Meston CM, Lorenz TA, Stephenson KR. Effects of expressive writing on sexual dysfunction, depression, and PTSD in women with a history of childhood sexual abuse: results from a randomized clinical trial. J Sex Med. 2013 Sep;10(9):2177-89. doi: 10.1111/jsm.12247. Epub 2013 Jul 22.
Clinical trial NCT00171002: Efficacy and Safety of Valsartan/Amlodipine Combination in Hypertensive Patients Not Controlled With Amlodipine Alone
Official title: A Multicenter Trial to Evaluate the Safety and Efficacy of the Combination of Valsartan/Amlodipine 160/10 mg Versus Amlodipine 10 mg Alone for 8 Weeks in Hypertensive Patients Who Are Not Adequately Controlled on Amlodipine 10 mg Monotherapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Hypertension
Keywords: Hypertension, high blood pressure, valsartan, amlodipine
Lead sponsor: Novartis
Sponsor class: INDUSTRY
First posted: 2005-09-15
Enrollment: 936
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will test the effectiveness and safety of a combination treatment in patients whose blood pressure is not controlled with a single medication


Eligibility criteria: Inclusion Criteria:

* Patients with uncomplicated, essential hypertension

Exclusion Criteria:

* Severe hypertension
* History of stroke, myocardial infarction, heart failure, chest pain, abnormal heart rhythm
* Liver, kidney, or pancreas disease
* Insulin dependent diabetes
* Allergy to certain medications used to treat high blood pressure

Other protocol-defined exclusion criteria may apply.

Primary outcomes:
measure: Change from baseline in diastolic blood pressure after 8 weeks
Secondary outcomes:
measure: Change from baseline in systolic blood pressure after 8 weeks
measure: Decrease in diastolic blood pressure of at least 10 mmHg or diastolic blood pressure less than 90 mmHg after 8 weeks
measure: Diastolic blood pressure less than 90 mmHg after 8 weeks
Other outcomes:
Locations:
city: Multiple Locations
country: Germany
city: Basel
country: Switzerland
facility: Novartis Pharmaceuticals
Study officials:
affiliation: Novartis Pharmaceuticals
name: Novartis Pharmaceuticals
role: STUDY_DIRECTOR
References:
citation: Schunkert H, Glazer RD, Wernsing M, Yen J, Macarie CE, Vintila MM, Romanova J. Efficacy and tolerability of amlodipine/valsartan combination therapy in hypertensive patients not adequately controlled on amlodipine monotherapy. Curr Med Res Opin. 2009 Nov;25(11):2655-62. doi: 10.1185/03007990903251193.
Clinical trial NCT06851702: Observational Study for the Evaluation of Immune-mediated Endocrinological Adverse Events in Patients With Hematological Malignancies and Subjected to Treatment With Immune-checkpoint Inhibitors
Official title: Observational Study for the Evaluation of Immune-mediated Endocrinological Adverse Events in Patients With Hematological Malignancies and Subjected to Treatment With Immune-checkpoint Inhibitors
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Hematological Malignancies
Keywords: immune-checkpoint inhibitors
endocrinological adverse events
Lead sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sponsor class: OTHER
First posted: 2025-02-28
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with hematological malignancies and subjected to treatment with immune-checkpoint inhibitors

Brief summary: Retrospective / prospective observational study of endocrinological adverse events in hematologic patients treated with immunological checkpoint inhibitors


Eligibility criteria: Inclusion Criteria:

Retrospective cohort

* patients aged\> 18 years
* cyto-histological diagnosis of mature lymphoproliferative syndrome of B or T lymphocyte origin
* advanced stage of illness (relapsed or refractory)
* patients undergoing treatment with immune anticheckpoint antibodies.
* written informed consent

Prospective cohort

* patients aged\> 18 years
* cyto-histological diagnosis of mature lymphoproliferative syndrome of B or T lymphocyte origin
* advanced stage of illness (relapsed or refractory)
* patients who are candidates for therapy with anticheckpoint immune antibodies (it is specified that this therapy is completely independent of the subject's participation in the study).
* written informed consent

Exclusion Criteria:

* Severe, acute and chronic medical or psychiatric disorders that may affect the interpretation of the study results or interfere with it.

Primary outcomes:
measure: Evaluate the incidence, type and severity of immune-related endocrine side effects
timeFrame: through study completion, an average of 2 years
Secondary outcomes:
measure: search for predictive criteria for the appearance of immune-mediated endocrine toxicities
timeFrame: through study completion, an average of 2 year
measure: impact of toxicity on the continuation of therapy
timeFrame: through study completion, an average of 2 year
measure: monitoring system for early diagnosis and management of toxicities
timeFrame: through study completion, an average of 2 year
Other outcomes:
Locations:
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero - Universitaria di Bologna
Study officials:
References: