Clinical trial NCT02852603: Study on Genetically Affected Sporadic Thoracic Aortic Aneurysm and Dissection
Official title: Study on Genetically Affected Sporadic Thoracic Aortic Aneurysm and Dissection
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dissection of Aorta, Thoracic
Aneurysm of Aorta, Thoracic
Keywords: dissection
aneurysm
thoracic aorta
Lead sponsor: Wuhan Asia Heart Hospital
Sponsor class: OTHER
Collaborators: name: Fu Wai Hospital, Beijing, China
First posted: 2016-08-02
Enrollment: 450
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with thoracic aortic aneurysm and dissection.

Brief summary: Mortality of thoracic aortic aneurysm and dissection (TAAD) remains high because of the huge blood lost from the aorta. Questions about the potentially genetic effects on sporadic TAAD are raised by researchers to explore the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

Detailed description: Thoracic aortic dissection (TAD) is a critical clinical condition partly due to the rupture of aortic aneurysm. Mostly, surgical treatment can reduce the symptoms and extend life span of patients with thoracic aortic aneurysm and dissection (TAAD). However, mortality of TAAD remains high because of the huge blood lost from the aorta. Sporadic TAAD was considered to be a server consequence of hypertension, though most patients with hypertension won't have TAAD as their final outcomes. Previous studies have revealed the associations between genetic abnormalities and familial TAAD, and genetic tests have applied to assist the diagnosis of certain TAAD. Therefore, the potentially genetic effects on sporadic TAAD are explored by researchers to understand the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

Eligibility criteria: Inclusion Criteria:

* Patients with thoracic aortic aneurysm and dissection not due to trauma

Exclusion Criteria:

* Inability of the patient, parent or guardian to give consent
* Unwillingness to provide a blood specimen or participate in the study

Primary outcomes:
measure: Numbers of patients having thoracic aortic aneurysm and/or dissection are recorded. Diagnosis are confirmed by imaging analysis (CTA and/or Ultrasound) or by doctors during the operations.
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Wuhan Asia Heart Hospital
state: Hubei
Study officials:
affiliation: Wuhan Asia Heart Hospital
name: Xuan Zheng, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: