Clinical trial NCT05577403: Effect of Mulligans Mobilization With Movement in Osteoarthritis Knee.
Official title: Effect of Mulligan's Mobilization With Movement Added With Isometric Exercises on Muscle Strength Pain and Disability Associated With Knee Osteoarthritis: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteo Arthritis Knee
Keywords: Isometric exercise
Osteoarthritis
Rehabilitation
Lead sponsor: Majmaah University
Sponsor class: OTHER
Collaborators: name: King Saud University
First posted: 2022-10-13
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Allocation: Randomized
Primary purpose: BASIC_SCIENCE

Brief summary: To evaluate the effect of Mulligan's mobilization with movement in osteoarthritis of the knee.

Detailed description: Patients with knee OA diagnosed at the orthopaedic clinic of Tumair general hospital and referred to the physiotherapy department who attended the rehabilitation centre of Majmaah university will be recruited.

Patients will be excluded if they had knee or hip injury, sensory deficits in the lower extremity, a history of lower-extremity surgery, or a history of a quadriceps or hamstring muscle injury, had low back-related leg pain, or had any contraindication to manual therapy.

The protocol was submitted to and approved by the Majmaah University Research Ethics committee (MUREC Dec.2/ COM-2021/19-3)

Participants will be requested to sign a written informed consent form approved by the institutional ethics committee. A total of 60 participants were randomly assigned to group A (experimental group): Mulligan's mobilization with movement MWM added isometric strength training, and group B (control group): Sham MWM added isometric strength training. Pre and post-test readings were taken at baseline, week 2, and week 4, respectively. The outcome measures for this study will be maximal voluntary isometric contraction of quadriceps strength (measured by ISOMOVE dynamometer), ROM, and Western Ontario and McMaster universities osteoarthritis (WOMAC) index.

Eligibility criteria: Inclusion Criteria:

* Patient with knee OA with radiological evidence of grade 2 or 3 of the Kellgren and Lawrence scale.
* Age between 40-65 years, unilateral or bilateral involvement (in the case of bilateral involvement, the more symptomatic knee was included), and pain in and around the knee.

Exclusion Criteria:

* Patient will be excluded, if they had any deformity of the knee, hip, or back, had any central or peripheral nervous system involvement.
* They had received steroids or intra-articular injection within the previous three months, uncooperative patients.

Primary outcomes:
measure: pain intensity
timeFrame: 6 weeks
measure: Range of Motion
timeFrame: 6 weeks
measure: Western Ontario and McMaster universities osteoarthritis (WOMAC) index
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Al Majma'ah
country: Saudi Arabia
facility: Rehabilitation center, Majmaah University
state: Riyadh
Study officials:
affiliation: Majmah University
name: Shahnaz Hasan, PhD
role: PRINCIPAL_INVESTIGATOR
References: