Clinical trial NCT05323604: Impact of Sarcopenia Using an Easy Psoas Area Measurement
Official title: Impact of Sarcopenia on Post-operative Course for Cancer Patients Operated of Colorectal Surgery Using a Simple Measurement Method of the Psoas Muscle Surface Area
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sarcopenia
Keywords: Sarcopenia
colorectal neoplasm
colorectal surgery
psoas muscles
Lead sponsor: Hôpital NOVO
Sponsor class: OTHER
First posted: 2022-04-12
Enrollment: 58
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients suffering from sarcopenia who had colorectal surgery for cancer.

Brief summary: The purpose of this study is to compare the post-operative course in patients suffering from sarcopenia who had colorectal surgery for cancer. Our primary outcome is the comparaison of the length of hospital stay in sarcopenic and non sarcopenic patients.

Detailed description: Sarcopenia is the loss of muscle mass that occurs usually with aging, but it may have multiple contributing factors, especially related to chronic diseases such as colorectal cancer.

When present, sarcopenia is predictive of poor post-operative course. The identification of sarcopenia needs either the identification of low muscle strength, low muscle quantity/quality, or finally a low physical performance.

Multiple clinical, biological or radiological tools were proposed. Our purpose is to compare the post-operative outcome of sarcopenic and non sarcopenic patients using a simple, available, reproducible and rapid radiological method, which will help the healthcare professionals to rapidly identify high risk patients for possible complicated and long post-operative course allowing them to take appropriate perioperative measures to reduce the risks.

Eligibility criteria: Inclusion Criteria:

* Patient operated on for colectomy or proctectomy with restoration of continuity for colorectal cancer between 1 January 2020 and 31 December 2021
* Patient who had a CT scan in the 2 months prior surgery
* Patient aged 18 years or older

Exclusion Criteria:

* Patients with inflammatory bowel disease (Crohn disease, haemorrhagic rectocolitis)
* Patients with neuromuscular pathology affecting their mobility
* Patients who were diagnosed positif to SARS COV 2 before or during hospitalisation
* Patients who refuse the collection of their data

Primary outcomes:
measure: Comparison of the average postoperative length of stay in sacopenic and non-sarcopenic patients
timeFrame: Until discharge from hospital, an average of 30 days
Secondary outcomes:
measure: Comparison between complication rate in sarcopenic and non sarcopenic patients
timeFrame: At the end of the 30 post-operative days
measure: Assessment of re-hospitalization rate between sarcopenic and non sarcopenic patients
timeFrame: At the end of the 30 post-operative days
measure: Comparison of the transfer rate to rehabilitation or nursing home center between sarcopenic and non sarcopenic patients
timeFrame: At the end of the 30 post-operative days
measure: Comparison of the length of stay in the rehabilitation center for sarcopenic and non sarcopenic transferred patients
timeFrame: At the end of the 30 post-operative days
Other outcomes:
Locations:
city: Pontoise
country: France
facility: Centre Hospitalier René Dubos
Study officials:
affiliation: Hospital René Dubos
name: Hicham El Masri
role: PRINCIPAL_INVESTIGATOR
References: