Clinical trial NCT04611984: OC and ICTP in Gingival Crevicular Fluid During Piezocision Accelerated Orthodontic Treatment
Official title: Osteocalcin and Cross-Linked C-Terminal Telopeptides of Type I Collagen in Gingival Crevicular Fluid During Piezocision Accelerated Orthodontic Tooth Movement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tooth Movement
Keywords: Tooth movement
Piezocision
Gingival crevicular fluid
Osteocalcin
Lead sponsor: Marmara University
Sponsor class: OTHER
First posted: 2020-11-02
Enrollment: 15
Sex: ALL
Minimum age (years): 13
Maximum age (years): 20
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The aim of this study was to evaluate the tooth movement with and without piezocision with regard to the levels of osteocalcin and cross-linked C-terminal telopeptides of type I collagen in the gingival crevicular fluid.

Detailed description: 15 systemically healthy subjects requiring extraction of the maxillary 1. premolars with distalization of the maxillary canines were enrolled to the study. Piezocisions were performed on the distal and mesial sides of the right maxillary canines while the left maxillary canines served as controls. Canine distalization was performed via closed-coil springs applying 150 g of force per side by using miniscrews as anchorage. Gingival crevicular fluid samples were collected from both mesial and distal sides of right and left maxillary canines at 0, 1, 7, 14 and 28 days. The gingival crevicular fluid levels of osteocalcin and cross-linked C-terminal telopeptides of type I collagen were determined by using ELISA. The rate of tooth movement was measured on 14 and 28 days.

Eligibility criteria: Inclusion Criteria:

* Class I, Class II or Class III malocclusion,
* Proclined incisors requiring extraction of the maxillary first premolars with subsequent retraction of the maxillary canines
* No previous orthodontic treatment
* Good oral hygiene and periodontal health (plaque and gingival indices less or equal 1, probing depth less or equal 3 mm, no radiographic bone loss).

Exclusion Criteria:

* having systemic diseases that could affect bone and tooth movement
* smoking

Primary outcomes:
measure: Gingival crevicular fluid osteocalcin level (ng/ml)
timeFrame: 28 days after canine distalization
measure: Gingival crevicular fluid cross-linked C-terminal telopeptides of type I level (ng/ml)
timeFrame: 28 days after canine distalization
Secondary outcomes:
measure: The amount of canine movement (mm)
timeFrame: Baseline (day 0) before canine distalization and, 14 and 28 days after canine distalization
measure: Retraction rate (mm/day) of canine movement
timeFrame: 14 and 28 days after canine distalization
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Marmara University Faculty of Dentistry
Study officials:
affiliation: Marmara University, Faculty of Dentistry, Department of Peridontology
name: Hatice Selin Yıldırım, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dibart S, Surmenian J, Sebaoun JD, Montesani L. Rapid treatment of Class II malocclusion with piezocision: two case reports. Int J Periodontics Restorative Dent. 2010 Oct;30(5):487-93.
citation: Alfaqeeh SA, Anil S. Osteocalcin and N-telopeptides of type I collagen marker levels in gingival crevicular fluid during different stages of orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2011 Jun;139(6):e553-9. doi: 10.1016/j.ajodo.2011.03.005.
citation: Raj SC, Praharaj K, Barik AK, Patnaik K, Mahapatra A, Mohanty D, Katti N, Mishra D, Panda SM. Retraction With and Without Piezocision-Facilitated Orthodontics: A Randomized Controlled Trial. Int J Periodontics Restorative Dent. 2020 Jan/Feb;40(1):e19-e26. doi: 10.11607/prd.3968.