Clinical trial NCT02537990: MDS-CAN: A Prospective National MDS Clinical Database and Local Tissue Bank
Official title: MDS-CAN: A Prospective National MDS Clinical Database and Local Tissue Bank
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Myelodysplastic Syndrome (MDS)
Lead sponsor: Sunnybrook Health Sciences Centre
Sponsor class: OTHER
Collaborators: name: Tom Baker Cancer Centre
name: CancerCare Manitoba
name: The Ottawa Hospital
name: Princess Margaret Hospital, Canada
name: Jewish General Hospital
name: Health Sciences Centre, Winnipeg, Manitoba
name: British Columbia Cancer Agency
name: Providence Health & Services
name: Vancouver Coastal Health
name: Juravinski Cancer Center
name: Réseau de Santé Vitalité Health Network
name: Royal Victoria Hospital, Canada
name: Capital Health, Canada
name: Saskatoon City Hospital
First posted: 2015-09-02
Enrollment: 1200
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Primary care clinic, referrals from community physicians.

Brief summary: The purposes of this study are: 1. To identify and quantify the health utilities and quality of life experienced by patients who have been diagnosed with MDS and what are their predictors. 2. Measure the effects of patient related factors like frailty and comorbidity on quality of life and overall survival or toxicity to therapy. 3. Assess how quality of life changes over time and what are its predictors. This will be valuable information that may guide therapy, transfusion practices, etc., as MDS is a chronic, incurable disease that is often progressive.

Detailed description: o Participants will be seen and assessed for the study every 6 (+/-1) months. Follow-up for routine clinical care will be dictated by the physician. Clinical information relevant to the MDS diagnosis is entered such as IPSS, IPSS-R, treatments received and responses. Transfusion dependence is recorded. Relevant laboratories such as ferritin, LDH, CBC etc are entered q 6 months. Hospitalizations, bleeding and infections are recorded.

Dates and causes of death are documented Dates of leukaemia transformation are documented. Patients undergoing allogeneic stem cell transplant are documented with date of transplant.

QOL is assessed every 6 months:

QOL instruments are QLQ-C30, QUALMS, EQ-5D and global fatigue scale

Disability, frailty, comorbidity and physical performance is recorded on a yearly basis Disability scale is the Lawton Brody SIADL scale Frailty is measured using the Rockwood clinical frailty scale The comorbidity elements necessary to calculate the Charlson comorbidity scale and the MDS-CI of Della Porta et al. are recorded Physical performance tests are grip strength, 10x stand sit test and the 4 meter walk test

Investigators will continue to enroll new patients throughout this study period of 6 years, but the plan (funding permitting) is to continue this registry indefinitely, with later questions to be addressed.

* Monitoring and auditing data are completed every quarter by a dedicated national registry project manager.
* Monthly data checks are completed to compare data entered into the registry against predefined rules for range or consistency with other data fields in the registry.
* Standard Operating Procedures to address registry operations and analysis activities, such as patient recruitment and data collection has been created and posted electronically in the database for all sites.
* Plan of 25% drop off from death has been assumed due to conversion to AML or non leukemia death and 5% from lost of follow up loss to follow up. This is with the purpose to address situations where variables are reported as missing, unavailable, "non-reported," uninterpreted, or considered missing because of data inconsistency or out-of-range.
* Participant's results will be summarized descriptively as a whole and by province. KM survival curves will be generated and compared using the log-rank test. Univariate and multivariate cox proportional hazard nodel of overall survival will be performed to detect significant association with baseline covariates and time-dependent covariates such as frailty, comorbidity and QOL scores using Statistical Analysis Software (SAS) PHREG procedure.

Eligibility criteria: Inclusion Criteria:

* New diagnosis of a Myelodysplastic syndrome
* New diagnosis of CMML-1/CMML-2 and MDS/MPN
* New diagnosis of low blast AML (blasts 20-30%) as defined by the WHO classification (Vardiman, 2002)
* Greater than 18 years of age at the time of diagnosis
* Able to read, write and speak English or French (non-English or French speaking patients may participate if appropriate translation is used)
* Able to consent.

Exclusion Criteria:

* Patients whose diagnostic bone marrow exceed 2 years prior signing consent
* Subjects with AML and bone marrow blast of 31% or more at the time of signing consent
* Prior allogenic cell transplant

Primary outcomes:
measure: quality of life
timeFrame: every 6 months up to 6 years
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Odette Cancer Center
state: Ontario
Study officials:
affiliation: Sunnybrook Health Science Centre
name: Rena Buckstein, MD FRCPC
role: STUDY_DIRECTOR
References:
citation: Buckstein R, Chodirker L, Mozessohn L, Yee KWL, Geddes M, Zhu N, Shamy A, Leitch HA, Christou G, Banerji V, Brian L, Khalaf D, St-Hilaire E, Finn N, Nevill T, Keating MM, Storring J, Delage R, Parmentier A, Thambipillai A, Siddiqui M, Westcott C, Cameron C, Mamedov A, Spin P, Tang D. A natural history of lower-risk myelodysplastic syndromes with ring sideroblasts: an analysis of the MDS-CAN registry. Leuk Lymphoma. 2022 Dec;63(13):3165-3174. doi: 10.1080/10428194.2022.2109154. Epub 2022 Sep 12.
citation: Buckstein R, Wells RA, Zhu N, Leitch HA, Nevill TJ, Yee KW, Leber B, Sabloff M, St Hilaire E, Kumar R, Geddes M, Shamy A, Storring J, Kew A, Elemary M, Levitt M, Lenis M, Mamedov A, Zhang L, Rockwood K, Alibhai SM. Patient-related factors independently impact overall survival in patients with myelodysplastic syndromes: an MDS-CAN prospective study. Br J Haematol. 2016 Jul;174(1):88-101. doi: 10.1111/bjh.14033. Epub 2016 Mar 15.