Clinical trial NCT04942821: The Evaluation Clinical Results of Coronally Advanced Flap With Platelet Rich Fibrin
Official title: Treatment of Multiple Adjacent Gingival Recessions With Coronally Advanced Flap in Combination With Platelet-Rich Fibrin: A Split-Mouth Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Root Coverage
Keywords: Gingival recession
Plastic surgery
Platelet rich fibrin
Connective tissue graft
Coronally advanced flap
Lead sponsor: Marmara University
Sponsor class: OTHER
First posted: 2021-06-29
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study was to evaluate the clinical outcomes of platelet- rich fibrin and coronally advanced flap technique in the treatment of multiple gingival recessions in comparison with connective tissue graft technique.

Detailed description: Aim of this study was to evaluate the clinical outcomes of platelet rich fibrin (PRF)+coronally advanced flap (CAF) technique in the treatment of multiple gingival recessions in comparison with connective tissue graft (CTG)+CAF technique.12 patients with bilateral Miller Class I multiple gingival recessions were treated with PRF+CAF (test group) and CTG+CAF (control group) technique in a split-mouth study design. Probing depth, recession depth (RD), clinical attachment level (CAL), recession width, position of gingival margin, papilla width, keratinized tissue height (KTH), keratinized tissue thickness (KTT) were measured at baseline and 3, 6 and 12 months after surgery. Root coverage (RC) and complete root coverage (CRC) ratios were evaluated post-operatively.

Eligibility criteria: Inclusion Criteria:

* Patients had at two quadrants, adjacent Miller Class I and at least 2 mm or deeper recessions
* Full mouth plaque score 20% and Full mouth bleeding on probing 10%
* no active periodontal disease,
* involving incisors, canines and premolars,
* age ≥ 18 years

Exclusion Criteria:

* Patients with general diseases which could affect healing process,
* smokers
* Patients had undergone periodontal surgery during the pervious 24 months on the involved sites,
* pregnant or breastfeeding women
* endodontic lesions or non-detectable cemento-enamel junctions at experimental teeth

Primary outcomes:
measure: Percentage of Root Coverage
timeFrame: 12 months
Secondary outcomes:
measure: Complete Root Coverage
timeFrame: 12 months
measure: Change from Baseline Keratinized Tissue Width at 3 months
timeFrame: 3 months
measure: Change from Baseline Keratinized Tissue Width at 6 months
timeFrame: 6 months
measure: Change from Baseline Keratinized Tissue Width at 12 months
timeFrame: 12 months
measure: Change from Baseline Gingival Thickness at 3 months
timeFrame: 3 months
measure: Change from Baseline Gingival Thickness at 6 months
timeFrame: 6 months
measure: Change from Baseline Gingival Thickness at 12 months
timeFrame: 12 months
Other outcomes:
Locations:
Study officials:
affiliation: Marmara University, Faculty of Denistry, Department of Periodontology
name: Hatice Selin Yıldırım, Dr.
role: STUDY_CHAIR
affiliation: Marmara University, Faculty of Denistry, Department of Periodontology
name: Başak Doğan, Prof. Dr.
role: STUDY_DIRECTOR
affiliation: Marmara University, Faculty of Denistry, Department of Periodontology
name: Atacan Yavuz, Dr.
role: PRINCIPAL_INVESTIGATOR
References: