Clinical trial NCT05797402: Clinical and Biological Sample Database of Chinese Elderly Patients With Multiple Diseases
Official title: Construction of Integrated Management and Sharing Platform for Clinical and Biological Sample Database of Chinese Elderly Patients With Multiple Diseases
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Comorbidities and Coexisting Conditions
Old Age; Debility
Keywords: Cognition Disorders
Frailty
Coronary heart disease
Atrial fibrillation
Stroke
Heart failure
Hypertension
Valvular heart disease
Lead sponsor: Beijing Anzhen Hospital
Sponsor class: OTHER
Collaborators: name: Chinese PLA General Hospital
name: Beijing Chao Yang Hospital
name: Beijing Tiantan Hospital
name: Beijing Geriatric Hospital
name: China-Japan Friendship Hospital
name: Xuanwu Hospital, Beijing
name: Wuhan TongJi Hospital
name: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
name: Beijing Friendship Hospital
First posted: 2023-04-04
Enrollment: 10000000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: hospital based group

Brief summary: The investigators aim to establish a clinical database and biobank for elderly patients with multiple diseases. The collected data will include demographic information, comorbidity characteristic, FRAIL scale, age-adjusted Charlson comorbidity index, relevant blood tests, the results of imaging examination, prescription of drugs, length of hospital stay, number of overall rehospitalizations and death. With this database, the investigators intend to formulate an individualized treatment strategy for these patients.

Detailed description: According to the China Health and Aging Tracking Survey, a significant proportion of elderly individuals aged over 65 suffer from two or more chronic diseases, with prevalence rates ranging from 22.5% to 47.5%. However, due to the decentralized storage of health data, lack of standardization, and collaboration barriers, it is challenging to make use of this information in a meaningful way.Therefore, there is an urgent need to overcome the technical challenges and build an intelligent diagnosis and treatment system for this vulnerable population.

To achieve this goal, it is necessary to establish a clinical database and biobank that includes data on all elderly patients with multimorbidity. This will enable researchers to conduct clinical research on various factors, including clinical and biological predictors of adverse events such as emergency visits, strokes, heart failure, myocardial infarction, tumors, and acute chronic obstructive pulmonary disease. Additionally, the database will facilitate the development of systematic and individualized evaluation tools for elderly patients with multimorbidity, identify prognostic factors that improve short- and long-term outcomes, and enable the participation in multi-center trials at the national or international level. Ultimately, this effort will help establish clinical database and biobank data collection standards for future studies.

Eligibility criteria: Inclusion Criteria:

* (1) written and informed consent, (2) participants aged 18 years or older.

Exclusion Criteria:

* (1) Unwilling to participate in the study, (2) Unable or unwilling to cooperate with the baseline or follow-up data collection.

Primary outcomes:
measure: The incidence of geriatric syndromes including falls, cognitive impairment, dizziness and frailty
timeFrame: 1 year
Secondary outcomes:
measure: The incidence of survival rate
timeFrame: 1 year
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Anzhen Hospital, Capital Medical University
Study officials:
References: