Clinical trial NCT04328350: Social Experiences of Adolescents and Young Adults With Cancer
Official title: Social Experiences of Adolescents and Young Adults With Cancer
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Childhood Cancer
Social Behavior
Social Competence
Lead sponsor: St. Jude Children's Research Hospital
Sponsor class: OTHER
First posted: 2020-03-31
Enrollment: 121
Sex: ALL
Minimum age (years): 15
Maximum age (years): 22
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All participants who meet eligibility criteria and consent to enrollment on the study.

Brief summary: Participants are being asked to take part in this clinical trial, a type of research study, because investigators want to learn more about the social experiences adolescents and young adults who are being treated or have been treated for cancer.

Primary Objectives

* Describe differences in social experience variables (peer connectedness, perceived social competence, parent versus peer attachment) based on treatment status: on versus off therapy.
* In on-therapy patients, describe differences in social experience variables (peer connectedness, perceived social competence, parent versus peer attachment) based on developmental stage: high school versus post-high school.

Secondary Objectives

* Assess the social support and peer interaction needs of AYA with cancer as a means of determining stakeholder interest and need for psychosocial interventions targeting social experiences.
* Using qualitative interviews, explore patient perceptions of the impact of cancer on social experiences among AYA, particularly with regards to changes in friendships as a result of the cancer diagnosis and the role of the hospital in helping or hindering friendship maintenance/development.

Exploratory Objectives

* Explore differences in social experience by demographic, disease and treatment factors, including: gender, diagnostic category (brain tumor, leukemia/lymphoma, solid tumor), late effects/symptom burden, and treatment (e.g., treatment intensity, serious medical events).
* Explore associations between perceived impact of cancer and social experience in AYA.
* Explore associations between use of social media and social experience.
* Explore associations between social experiences and overall functioning (quality of life, distress, coping).
* Explore the possibility of subclasses of AYA by using person-centered analyses to empirically derive profiles of social experience.

Detailed description: A mixed-methods design involving questionnaires and interviews will be used to evaluate the study objectives. AYA ages 15 to 22 will be recruited to participate. Two cohorts will be enrolled: AYA who are on-treatment, 2-12 months post-diagnosis; and AYA who are off-therapy 1 to 4 years. AYA will complete questionnaires assessing peer versus family connectedness, peer/romantic competence, coping, distress, social support, and quality of life. A study-specific needs assessment regarding interest in social functioning interventions will also be completed. If a caregiver is available, they will be asked to complete questionnaires regarding family functioning and quality of life. A subset of 50 AYA (30 on-therapy/20 off-therapy) will be interviewed to further explore aspects of peer/family connectedness and intervention interest. Analyses will focus on describing how aspects of social experiences (peer connectedness, social competence, peer versus parent attachment) differ based on treatment status (on versus off therapy) and developmental stage (high school versus post-high school), as well as potential moderators.

Two cohorts of AYA with cancer, ages 15-22, will be identified and recruited for the study: 1) patients on-therapy, 2-12 months from diagnosis; and 2) patients off- therapy 1-4 years, and ≥13 years of age at diagnosis. AYA from all diagnostic groups - brain tumor, solid tumor, leukemia/lymphoma - and developmental periods - high school, post-high school - will be targeted, and care will be taken to ensure a representative sample.

Eligibility criteria: Inclusion Criteria:

* All Participants
* Age 15 - 22
* Primary oncology diagnosis.
* Reads and speaks English.
* On-Therapy Strata

  * 2 - 12 months from diagnosis and receiving cancer-directed therapy.
* Off-Therapy Strata

  * 1 - 4 years post-treatment, diagnosed at ≥13 years of age.
* Caregivers Reads and speaks English
* Consent received from adult participant to contact, as it applies

Exclusion Criteria:

* Surgery only treatment plan.
* IQ less than 70 as documented in the medical record.
* Diagnosis of a genetic disorder/pre-existing neurodevelopmental condition associated with neurocognitive or social impairment (e.g., autism, Neurofibromatosis Type 1 (NF1), Down syndrome).
* Inability or unwillingness of research participant or legal - guardian/representative to give written informed consent.

Primary outcomes:
measure: Inventory of Parent and Peer Attachment (IPPA).
timeFrame: Baseline
measure: UCLA Loneliness Scale.
timeFrame: Baseline
measure: Family Management Measure (FMM).
timeFrame: Baseline
measure: Self-Perception Profile for Adolescents/Emerging Adults (SPPA/EA).
timeFrame: Baseline
measure: NIH Toolbox - Friendship
timeFrame: Baseline
Secondary outcomes:
measure: Young Adult Cancer Impact Scale
timeFrame: Baseline
measure: Centrality of Events (COE).
timeFrame: Baseline
measure: Online Social Support Scale (OSSS).
timeFrame: Baseline
measure: Multidimensional Scale of Perceived Social Support (MSPSS).
timeFrame: Baseline
measure: Responses to Stress Questionnaire (RSQ)
timeFrame: Baseline
measure: PROMIS Profile / Pediatric Profile
timeFrame: Baseline
measure: PedsQL - Cancer Specific Module
timeFrame: Baseline
measure: PedsQL - Core Module
timeFrame: Baseline
measure: Intensity of Treatment (ITR-3).
timeFrame: Baseline
measure: Needs Assessment
timeFrame: Baseline
measure: Qualitative Interview
timeFrame: Baseline
Other outcomes:
Locations:
city: Memphis
country: United States
facility: St. Jude Children's Research Hospital
state: Tennessee
Study officials:
affiliation: St. Jude Children's Research Hospital
name: Sarah W. Daniels, PhD
role: PRINCIPAL_INVESTIGATOR
References: