Clinical trial NCT03830268: Acute Medium Chain Triglycerides (MCT) Intake in Young and Older Participants
Official title: Optimisation of Acute Medium Chain Triglycerides Intake Characteristics on Different Plasma Metabolites in Young and Older Participants
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ketonemia
Keywords: Ketones
Medium Chain Triglycerides
Glucose
Insulin
Free fatty acids
Lead sponsor: Université de Sherbrooke
Sponsor class: OTHER
First posted: 2019-02-05
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 10 young and 10 older participants undergoing six separate but identical metabolic visits (interventions)
Primary purpose: BASIC_SCIENCE

Brief summary: Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.


Eligibility criteria: Inclusion Criteria:

* 10 health young (20-40 y old) and 10 health older (\> 60 y old) participants
* Men and women

Exclusion Criteria:

* smoking
* diabetes (fasting glucose \>7.0 mmol/l and glycated hemoglobin \>6.9%)
* strenuous aerobic exercise more than three times a week
* untreated hypertension, dyslipidemia, and abnormal renal, liver, heart or thyroid function
* under medication known to affect triglycerides and carbohydrates metabolism (i.e. diuretics, beta-blockers, steroids, insulin sensitizing)

Primary outcomes:
measure: Concentration of plasma ketones (acetoacetate and B-hydroxybutyrate)
timeFrame: 8 hours
Secondary outcomes:
measure: Concentration of plasma glucose
timeFrame: 8 hours
measure: Concentration of plasma insulin
timeFrame: 8 hours
measure: Concentration of plasma free fatty acids
timeFrame: 8 hours
Other outcomes:
Locations:
city: Sherbrooke
country: Canada
facility: Rearsh Centre on Aging
state: Quebec
Study officials:
References:
citation: Cunnane SC, Courchesne-Loyer A, St-Pierre V, Vandenberghe C, Pierotti T, Fortier M, Croteau E, Castellano CA. Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease. Ann N Y Acad Sci. 2016 Mar;1367(1):12-20. doi: 10.1111/nyas.12999. Epub 2016 Jan 14.
citation: Croteau E, Castellano CA, Fortier M, Bocti C, Fulop T, Paquet N, Cunnane SC. A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease. Exp Gerontol. 2018 Jul 1;107:18-26. doi: 10.1016/j.exger.2017.07.004. Epub 2017 Jul 12.
citation: Courchesne-Loyer A, Croteau E, Castellano CA, St-Pierre V, Hennebelle M, Cunnane SC. Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study. J Cereb Blood Flow Metab. 2017 Jul;37(7):2485-2493. doi: 10.1177/0271678X16669366. Epub 2016 Jan 1.
citation: Courchesne-Loyer A, Fortier M, Tremblay-Mercier J, Chouinard-Watkins R, Roy M, Nugent S, Castellano CA, Cunnane SC. Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism. Nutrition. 2013 Apr;29(4):635-40. doi: 10.1016/j.nut.2012.09.009. Epub 2012 Dec 28.
citation: Castellano CA, Nugent S, Paquet N, Tremblay S, Bocti C, Lacombe G, Imbeault H, Turcotte E, Fulop T, Cunnane SC. Lower brain 18F-fluorodeoxyglucose uptake but normal 11C-acetoacetate metabolism in mild Alzheimer's disease dementia. J Alzheimers Dis. 2015;43(4):1343-53. doi: 10.3233/JAD-141074.