Clinical trial NCT06002750: Evaluation of Tp-e Interval and Tp-e/QT Ratio in Dermatomyositis and Analysis of Their Relationship With Inflammation
Official title: The Third People's Hospital of Hangzhou
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dermatomyositis
Myocardial Repolarization
Inflammation
Lead sponsor: The Third People's Hospital of Hangzhou
Sponsor class: OTHER
First posted: 2023-08-21
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Dermatomyositis patients from November 2011 to November 2022 who visited our hospital, and a healthy control group consisting of the same number of gender and age matched healthy adults in a physical examination center.

Brief summary: The goal of this observational study is to investigate ventricular repolarization utilizing Tp-e intervals and Tp-e/QT ratios in patients with DM. The main questions it aims to answer are:

* 1.Exploring the changes in ventricular repolarization parameters (QT interval, QTc interval, QTd, Tp-e interval, Tp-e/QT ratio) in patients with dermatomyositis, providing quantifiable indicators for early detection of arrhythmia in dermatomyositis patients;
* 2.Exploring the role of inflammation in ventricular repolarization in DM patients, providing a basis for in-depth research on the diagnosis and prevention of arrhythmia in DM patients.


Eligibility criteria: Inclusion Criteria:

Regardless of gender, registered residence and education level, voluntarily participate in this study and sign the informed consent form.

Clinical diagnosis of Dermatomyositis.

Exclusion Criteria:

Previous history of heart disease (such as myocardial infarction, cardiac pacing, congenital heart disease, ischemic heart disease, etc.), chronic kidney disease, etc; Patients with other connective tissue diseases; Pregnant and lactating women.

Taking drugs that affect electrocardiogram indicators, such as macrolides, quinolones, quinidine, amiodarone, antipsychotic drugs, etc.

Patients with severe lack of case data.

Primary outcomes:
measure: QTc, Tp-e interval, and Tp-e/QT ratio were increased in DM patients.
timeFrame: November 2011 to November 2022
measure: the Tp-e interval and Tp-e/QT ratio were positively correlated with Inflammation.
timeFrame: November 2011 to November 2022
Secondary outcomes:
Other outcomes:
Locations:
city: Zhejiang
country: China
facility: The Third People's Hospital of Hangzhou
state: Hangzhou
Study officials:
References:
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