Clinical trial NCT04376268: Comparison of the Efficacy of Boric Acid Mouthwashes in Different Concentrations
Official title: Comparison of the Efficacy of Boric Acid Mouthwashes in Different Concentrations in the Lower Third Molar Surgery in the Postoperative Period
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE4
Conditions: Impacted Third Molar Tooth
Keywords: postoperative complications
impacted tooth
mouthwash
boric acid
chlorhexidine
Lead sponsor: Yuzuncu Yıl University
Sponsor class: OTHER
First posted: 2020-05-06
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: Surgical removal of impacted third molars is one of the most frequent procedures carried out in the oral and maxillofacial surgery clinics. There are a varying range of postoperative complications including pain, edema and swelling. Antibiotics, analgesics and mouthwashes are usually prescribed for the treatment of these complications. Patients undergoing impacted third molar surgery are frequently prescribed chlorhexidine mouthwashes with/without benzydamine hydrochloride. However, there has been a search for alternatives with anti-inflammatory, antibacterial and analgesic properties as part of the oral care routine following surgical removal of impacted third molars. Thus, this multicenter study was aimed to evaluate the effects of chlorhexidine mouthwashes with different boric acid concentrations (%0.1, %0.5, %1, %1.5, %2 and %2.5), and boric acid mouthwash on the postoperative complications and compared with chlorhexidine mouthwash after the removal of impacted wisdom teeth.


Eligibility criteria: Inclusion Criteria:

* absence of any systemic disease
* having impacted mandibular third molar teeth in a similar position
* absence of allergy to any of the drugs used in the study,
* absence of pregnancy/lactating state,
* no history of any medication use during at least 2 week before the operation.

Exclusion Criteria:

* not regularly coming to the controls,
* not using their medicines regularly
* using any additional medication that may affect the outcome of the study

Primary outcomes:
measure: Postoperative Pain
timeFrame: Postoperative 1st day
measure: Postoperative Swelling
timeFrame: Postoperatif 1st day
measure: Postoperative Trismus
timeFrame: Postoperative 1st day
measure: Postoperative Pain
timeFrame: Postoperative 2nd day
measure: Postoperative Pain
timeFrame: Postoperative 3rd day
measure: Postoperative Swelling
timeFrame: Postoperatif 3rd day
measure: Postoperative Trismus
timeFrame: Postoperative 3rd day
measure: Postoperative Pain
timeFrame: Postoperative 4th day
measure: Postoperative Pain
timeFrame: Postoperative 5th day
measure: Postoperative Pain
timeFrame: Postoperative 6th day
measure: Postoperative Pain
timeFrame: Postoperative 7th day
measure: Postoperative Swelling
timeFrame: Postoperatif 7th day
measure: Postoperative Trismus
timeFrame: Postoperative 7th day
Secondary outcomes:
Other outcomes:
Locations:
city: Van
country: Turkey
facility: Van Yuzuncu Yil University, Faculty of Dentistry
Study officials:
References: