louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03171402: Astringency and Bitterness Perception
Official title: Astringency and Bitterness Perception Among High and Low Fruit and Vegetable Consumers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Taste Bitter-Salty
Lead sponsor: Purdue University
Sponsor class: OTHER
First posted: 2017-05-31
Enrollment: 92
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: * Not underweight (BMI \> 18 kg/m\^2)
* Not be trying to gain or lose weight
* Males and females 18-45
* No known issues with taste, smell, swallowing, choking, or salivation

Brief summary: The investigators are conducting a study to better understand how the average consumer differentiates between bitter and astringent sensations, both of which are typically unpleasant sensations characteristic of some healthy foods. Astringency is the dry/rough sensation elicited by foods such as green bananas and some wines. Although trained scientists can differentiate between these stimuli, untrained participants rate them similarly, despite their differences. This confusion has created additional barriers in understanding the mechanism of astringent perception, which is currently debated. Understanding how to design experiments where untrained participants can clearly evaluate both sensations will lay the foundation to better understand astringency.

One mechanism that is believed to contribute to astringency is the interaction of astringent stimuli with salivary proteins. Interestingly, the salivary protein profile may be influenced by consumption of fruits and vegetables. Therefore, the investigators will evaluate how bitter and astringent perceptions differ among high and low consumers of fruits and vegetables by collecting saliva following exposure to the stimuli. This knowledge will inform approaches to increase the appeal of healthy food.


Eligibility criteria: Inclusion Criteria:

* BMI \> 18

Exclusion Criteria:

* issues with taste, smell, swallowing, choking, or salivation
* trying to gain or lose weight

Primary outcomes:
measure: Participant-generated sensory ratings of consumed samples
timeFrame: Through study completion, an average of three 30-minute visits
measure: Participant-generated groupings of consumed samples
timeFrame: Through study completion, an average of three 60-minute visits
measure: Participant-generated ratings of consumed samples relative to reference samples
timeFrame: Through study completion, an average of three 60-minute visits
measure: Participant-generated "check-all-that-apply" ratings of consumed samples
timeFrame: Through study completion, an average of three 30-minute visits
Secondary outcomes:
Other outcomes:
Locations:
city: West Lafayette
country: United States
facility: Purdue University
state: Indiana
Study officials:
References:
Clinical trial NCT06330402: Exploration of Gait Biomechanics and Pain
Official title: Undersøgelse af sammenhængen Mellem Biomekanik og Smerter Ved Gang
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Pain
Healthy
Lead sponsor: Aalborg University
Sponsor class: OTHER
First posted: 2024-03-26
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This interventional study aims to test gait biomechanics in healthy individuals with and without experimental knee pain. The main questions it aims to answer are:

* How do gait patterns change during painful walking?
* Can pain sensitivity testing and gait biomechanics predict experimental knee pain intensity?

Participants will receive two knee injections: a) Hypertonic saline (painful condition) and b) Isotonic saline (control condition).

Detailed description: This study will be a randomized, crossover design where experimental knee pain will be provoked in healthy subjects using hypertonic saline injections to the infrapatellar fat pad (IFP). This will be controlled with a second injection of isotonic saline, which is non-painful. The participants will not be informed of the type of injection.

Hypertonic saline injections to the IFP usually provoke pain lasting about 15 minutes. Within this timeframe, motion capture will be conducted to estimate the biomechanics of gait. During the motion capture the participants will perform five 10-meter walking trials and three jumps. This process will be replicated for the control condition.

Additionally, the participants will have their pain sensitivity tested using cuff-pressure algometry before both IFP injections.

Eligibility criteria: Inclusion Criteria:

* Healthy men and women aged 18-45 years

Exclusion Criteria:

* Pregnancy
* Drug addiction, defined as the use of cannabis, opioids, or other drugs
* Previous or current neurologic or musculoskeletal illnesses
* Current pain
* Lack of ability to cooperate

Primary outcomes:
measure: Infrared marker XYZ coordinates
timeFrame: Baseline
measure: Pain sensitivity.
timeFrame: Baseline
Secondary outcomes:
measure: The Pittsburgh Sleep Quality Index score
timeFrame: Baseline
measure: The Pain catastrophizing Scale score
timeFrame: Baseline
measure: The Hospital Anxiety and Depression Scale
timeFrame: Baseline
measure: Knee symptoms
timeFrame: Baseline
measure: Ground reaction forces
timeFrame: Baseline
measure: Ground reaction moments
timeFrame: Baseline
measure: Ground contact XZ location
timeFrame: Baseline
measure: Muscle activation
timeFrame: Baseline
Other outcomes:
measure: Pain intensity (NRS 0-10)
timeFrame: Baseline
measure: Pain distribution
timeFrame: Baseline
Locations:
city: Aalborg
country: Denmark
facility: Aalborg University
state: Nordjylland
Study officials:
References:
Clinical trial NCT01831102: Adiponectin and Ethnic Differences in Insulin Resistance
Official title: Adiponectin as an Independent Determinant of Ethnic Differences in Insulin Resistance
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Insulin Resistance
Type 2 Diabetes
Keywords: insulin resistance
ethnic disparities
adiponectin
Lead sponsor: University of Colorado, Denver
Sponsor class: OTHER
First posted: 2013-04-15
Enrollment: 43
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community sample

Brief summary: The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects. The investigators also aimed to examine associations between nutritional factors and adiponectin levels.


Eligibility criteria: Inclusion Criteria:

* 18-60 years of age
* BMI 20.0-34.9 m/kg2
* Mexican American with at least 3 grandparents born in Mexico or white with no grandparents of Latino descent.

Exclusion Criteria:

* pregnancy
* breastfeeding
* diabetes mellitus
* blood pressure \> 160/100 mmHg
* creatinine \> 1.5 mg/dl or glomerular filtration rate (GFR) \< 60
* liver function tests \> 3x upper limit of normal (ULN)
* h/o heart failure
* h/o eating disorder

Primary outcomes:
measure: total adiponectin concentration
timeFrame: measured once during second study visit, in fasting condition
Secondary outcomes:
measure: Insulin sensitivity
timeFrame: Measured once, during second study visit.
Other outcomes:
Locations:
city: Aurora
country: United States
facility: University of Colorado Anschutz Medical Center
state: Colorado
Study officials:
affiliation: University of Colorado, Denver
name: Rocio Pereira, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01360502: Safety of Capsule Endoscopy in Patients With Implantable Cardiac Devices
Official title: Safety of Capsule Endoscopy Using Human Body Communication in Patients With Cardiac Pacemakers and Implantable Cardiac Defibrillators
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Gastrointestinal Disease
Anemia
Keywords: capsule endoscopy
cardiac pacemaker
implantable cardiac defibrillator
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2011-05-25
Enrollment: 6
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with implantable cardiac devices

Brief summary: This is a prospective study designed to assess safety and potential influence of the MiroCam on cardiac pacemaker and implantable cardiac defibrillator.

Detailed description: MiroCam (IntroMedic, Ltd, Seoul, Korea) is a small bowel capsule endoscope using human body communication for data transmission. There is a concern of potential interactions between cardiac devices and capsule endoscope. This clinical study was designed to evaluate the potential influence of the MiroCam on cardiac pacemaker and implantable cardiac defibrillator.

Eligibility criteria: Inclusion Criteria:

1. age 20 years or older
2. cardiac pacemaker or implantable cardiac defibrillator
3. gastrointestinal disease

Exclusion Criteria:

1. previous GI perforation or obstruction history
2. known or suspected GI stricture
3. marked GI dysmotility
4. uncompensated heart failure (EF ≤30% or Killip's classification class ≥ III)
5. pregnancy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
Study officials:
affiliation: Yonsei University
name: Si Young Song, M.D., Ph.D.
role: STUDY_CHAIR
References:
Clinical trial NCT04046302: Vaginal Dinoprostone Administration Prior to an Intrauterine Device Insertion in Multiparous Women.
Official title: Effect of Self-Administered Vaginal Dinoprostone on Pain Perception During Copper Intrauterine Device Insertion in Parous Women: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: IUD Insertion
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2019-08-06
Enrollment: 160
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To investigate whether vaginal dinoprostone administered before intrauterine device (IUD) insertion reduces failed insertions, insertion-related complications, and pain in multiparous women.

Detailed description: Women may experience pain and technical difﬁculties may be encountered when insertion of an intrauterine device (IUD) is attempted through a narrow cervical canal.IUD insertion- related complications and side effects are more common among women who had never delivered vaginally. Pain can be perceived during all steps of IUD insertion including the application of the tenaculum to the cervical lip, sounding the uterus and advancing the IUD introducer through the cervical canal inside the uterine cavity

Eligibility criteria: Inclusion Criteria:

* multiparous women aged over 18 years of age requesting an IUD for contraception, had a negative pregnancy test.

Exclusion Criteria:

* currently pregnant or were pregnant within 6 weeks of study entry
* had a prior attempted or successful IUD insertion
* had a history of a cervical procedure such as cone biopsy, Loop electrosurgical excision procedure, or cryotherapy
* any World Health Organization Medical Eligibility Criteria category 3 or 4 precaution to an IUD
* active vaginitis or cervicitis
* undiagnosed abnormal uterine bleeding
* pelvic inﬂammatory disease within the last 3 months
* ﬁbroids or other uterine abnormalities distorting the uterine cavity
* contraindication or allergy to dinoprostone.

Primary outcomes:
measure: the difference in the pain intensity scores between the study groups
timeFrame: 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: faculty of medicine Cairo university
Study officials:
affiliation: Cairo University
name: AHMED SAMY
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ashour AS, Nabil H, Yosif MF, Hussein M, Mageed A Allah AA, Mahmoud M, Abdou H, Kholaif K, Mohamed Kotb MM, El Sharkawy M, Abdelhakim AM, Ali AS, Nassar SA, Abbassy AH, Ghamry NK, Abdel-Latif AA, Taher A, El Mahy M. Effect of self-administered vaginal dinoprostone on pain perception during copper intrauterine device insertion in parous women: a randomized controlled trial. Fertil Steril. 2020 Oct;114(4):861-868. doi: 10.1016/j.fertnstert.2020.05.004. Epub 2020 Jul 28.
Clinical trial NCT04854902: Cyanoacrylate Use in Free Gingival Graft
Official title: The Effects of Cyanoacrylate on Self-reported Outcomes and Healing Following Free Gingival Graft Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Gingival Recession, Localized
Lead sponsor: Biruni University
Sponsor class: OTHER
First posted: 2021-04-22
Enrollment: 23
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Present study aims to reveal the effects of cyanoacrylate application at the recipient bed and the donor site in free gingival graft surgery on the healing parameters and patient-based outcomes.


Eligibility criteria: Inclusion Criteria:

* Single-tooth gingival recession in the anterior mandibular region
* Pain with chewing or oral hygiene practice
* Ongoing recession

Exclusion Criteria:

* Systemic disease
* Smoking
* Pregnancy / lactation

Primary outcomes:
measure: Re-epithelization
timeFrame: one week after the surgery
measure: Re-epithelization
timeFrame: two weeks after the surgery
measure: Re-epithelization
timeFrame: three weeks after the surgery
measure: Post-operative pain
timeFrame: 1st week
measure: Post-operative pain
timeFrame: 2nd week
measure: Post-operative pain
timeFrame: 3rd week
measure: Post-operative pain
timeFrame: 4th week
measure: Oral health impact profile (OHIP-14)
timeFrame: Baseline
measure: Oral health impact profile (OHIP-14)
timeFrame: 3rd day
measure: Oral health impact profile (OHIP-14)
timeFrame: 1st week
measure: Oral health impact profile (OHIP-14)
timeFrame: 1st month
measure: Graft dimensions
timeFrame: 1st month
measure: Graft dimensions
timeFrame: 3rd month
measure: Graft dimensions
timeFrame: 6th month
Secondary outcomes:
measure: Mucosal thickness
timeFrame: In the beginning of the surgery (baseline)
measure: Paresthesia / hyperesthesia in the donor site
timeFrame: 1st month
measure: Color harmony
timeFrame: 1st week
measure: Color harmony
timeFrame: 2nd week
measure: Color harmony
timeFrame: 1st month
measure: Color harmony
timeFrame: 3rd month
measure: Color harmony
timeFrame: 6th month
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Biruni University
Study officials:
affiliation: Biruni University, assistant professor
name: Mustafa YILMAZ, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06755502: Garlic Oil As Root Filling Material in Primary Molars
Official title: Evaluation of Allium Sativum As Root Filling Material for Primary Molars Indicated for Non Vital Pulp Therapy: Randomized Clinical Trials
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Irreversible Pulpitis (toothache)
Keywords: RCT
garlic oil
natural remedies
primary molars
root canal filling material
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-01-01
Enrollment: 40
Sex: ALL
Minimum age (years): 4
Maximum age (years): 8
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this study is to test garlic oil mixed with zinc oxide as a potential root canal filling material of primary molars in children aged from four to eight years.

the study hypothesized that garlic oil mixed with zinc oxide would be the same as the gold standard filling material (metapex).

The group receiving the garlic oil with zinc oxide as root canal filling material will be compared with other similar group receiving metapex as root canal filling material in terms of clinical and radio-graphic success, and working time.

Detailed description: This study is a randomized clinical trial (RCT), that aims compare the clinical and radio-graphic success of garlic oil mixed with zinc oxide, used as root canal filling material in primary molars in children aged from four to eight years, with the conventional root filling material, which is metapex.

Eligibility criteria: Inclusion Criteria:

1. Primary second molars which are diagnosed with irreversible pulpitis, or pulp necrosis.
2. Presence of sinus tract.
3. Periapical bone swelling.
4. Continuous bleeding after amputation of the coronal pulp tissue.
5. No pulp tissue remains when the pulp chamber is accessed.
6. Pus discharges from the canal.
7. Radiographically, only primary molars with at least two-thirds of the root length.
8. Presence of inter-radicular or periapical radiolucency.

Exclusion Criteria:

1. A tooth with internal root resorption will not be included. 2. Excessive tooth mobility beyond healing. 3. Carious perforation in the pulpal flour. 4. A tooth with a pathological lesion extending to the successor's tooth germ. 5. Non-restorable primary molars.

-

Primary outcomes:
measure: The clinical success rate
timeFrame: 3, 6,9,and 12 months
measure: Radio-graphic success
timeFrame: 6, and 12 month.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02812602: Topical Anesthesia for Removal of Stitches After Total Knee Arthroplasty
Official title: Topical Anesthesia With Lidocaine Patch for Removal of Metal Staples After Total Knee Arthroplasty: A Prospective Randomized Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Metal Staple Removal After Total Knee Replacement
Keywords: Total Knee Replacement
Stitch
Removal
Pain
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2016-06-24
Enrollment: 60
Sex: ALL
Minimum age (years): 50
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Lidocaine patch is a safe and effective topical anesthetic agent for removal of metal staples after total knee replacement

Detailed description: This is a double-blind randomised control trial. After informed consent, the patients who undergoes primary total knee replacement will be assigned to either control group or experimental group randomly. The effectiveness and complication will be analysed.

If the patients are not medically fit for the study (including contraindications for lidocaine), they will be excluded.

Eligibility criteria: Inclusion criteria:

1. Males and females, aged 50-100 years
2. The patients who undergo primary total knee replacement (performed by the same surgeon, Dr.Jiang)
3. Clear consciousness
4. No contraindication for staple removal on the post-operative day 7

Exclusion criteria:

1. Allergy to lidocaine
2. Patient with second or third degree atrio-ventricular block
3. Patients with severe Sinoatrial node block
4. Patients taking class I antiarrhythmia drugs
5. Pregnant patients
6. Patients undergoing revision total knee replacement
7. Contraindication for removal of staples on post-operative day 7

Primary outcomes:
measure: Visual analog scale for pain
timeFrame: 30min
Secondary outcomes:
measure: Complication rate of lidocaine patch
timeFrame: Two weeks
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
state: Test2
Study officials:
affiliation: Department of Orthopedic Surgery, National Taiwan University Hospital
name: Ching-Chuan Jiang
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01836302: Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)
Official title: Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Septic Shock
Delirium
Renal Failure
Lead sponsor: University of Manitoba
Sponsor class: OTHER
First posted: 2013-04-19
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients admitted to the Intensive Care Unit with Septic Shock

Brief summary: Delirium in the ICU is a prevalent problem occurring in up to 80% of ICU patients. A potential cause of delirium in ICU patients could be cerebral hypoxia. Septic shock is associated with high rates of delirium.

The aim of this pilot study is two fold. First, to determine the feasibility and potential challenges of measuring cerebral oxygenation in ICU patients with severe sepsis and septic shock. And second, to see if the incidence and magnitude of cerebral desaturations correlated with ICU acquired delirium as measured by the Confusion Assessment Method (CAM) scores.


Eligibility criteria: Inclusion Criteria:

* Over 18
* Diagnosis of septic shock
* Require mechanical ventilation and vasopressor therapy

Exclusion Criteria:

* Previous stroke
* Dementia
* Recent Craniotomy

Primary outcomes:
measure: Incidence of Delirium
timeFrame: 28 Days
Secondary outcomes:
measure: Death
timeFrame: 28 Days
Other outcomes:
measure: Renal Failure
timeFrame: 28 Days
Locations:
city: Winnipeg
country: Canada
facility: Health Sciences Center
state: Manitoba
Study officials:
References: