Clinical trial NCT00285350: Mycophenolate Mofetil in Myasthenia Gravis
Official title: A Trial of Mycophenolate Mofetil in Myasthenia Gravis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Myasthenia Gravis
Keywords: myasthenia gravis
Lead sponsor: FDA Office of Orphan Products Development
Sponsor class: FED
Collaborators: name: Duke University
First posted: 2006-02-02
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a prospective, multi-center, double-blind, placebo-controlled trial to determine the efficacy and safety of mycophenolate mofetil (MM) in combination with prednisone as the initial form of immunosuppression in patients with acquired myasthenia gravis (MG).

Detailed description: 80 patients with seropositive MG at 18 academic centers will be randomized to 3 months of treatment with 2.5 gm MM/day (1,250 mg q 12 hours, +/- 2 hours) plus 20 mg prednisone/day versus placebo plus 20 mg/day prednisone. The primary measure of efficacy will be the change from baseline in Quantitative MG (QMG) score at the end of 3 months. Secondary outcome measures include survival analysis for treatment failure, MG-related impairment of daily activities, functional assessment, manual muscle testing, SF-36 Health Status, and serum concentration of antibodies to the acetylcholine receptor. Study completers will have the option of taking open-label MM for an additional 6 months, during which prednisone will be reduced to the lowest dose necessary to maintain the optimum clinical response.

Eligibility criteria: Inclusion criteria

1. Acquired generalized MG diagnosed by one of the Principal Investigators based on:

   * Examination by site PI showing myasthenic weakness that is not limited to the ocular or peri-ocular muscles.
   * Elevated acetylcholine receptor antibodies.
   * Positive edrophonium chloride test or abnormal neuromuscular transmission demonstrated by single fiber EMG or repetitive nerve stimulation.
2. Aged at least 18.
3. Able to give informed consent.
4. Taking a constant dose of Mestinon for at least 2 weeks.
5. Symptom severity that would, in the judgment of the site investigator, justify initiation of immunosuppressive treatment.
6. Able and willing to comply with study requirements.

Exclusion criteria

1. Thymoma now or in the past.
2. Plasma exchange or IVIG treatment within 90 days of randomization.
3. Treatment with azathioprine, cyclosporine, mycophenolate mofetil, or other immunosuppressive medication since onset of MG. Treatment with prednisone or other corticosteroids within the previous 90 days.

   • Exception: patients may have taken doses of these immunosuppressant medications that are judged by the Principal Investigator to have been clinically insignificant, i.e. unlikely to produce improvement in MG.
4. Women of childbearing potential who are pregnant, breast-feeding or not practicing effective contraception.
5. Renal failure, active thyroid or hepatocellular disease, chronic infection, poorly controlled cardiac disease, or any other illness, including psychiatric disease, that would, in the opinion of the treating physician, make it unsafe for the patient to participate or would interfere with the interpretation of study results.
6. Weakness affecting only ocular or peri-ocular muscles (Myasthenia Gravis Foundation of America Class I).
7. Severe weakness predominantly affecting oropharyngeal, respiratory muscles or both (MGFA Class IVB).
8. Crisis or impending crisis (defined as FVC \<10ml/Kg or bulbar weakness severe enough to compromise airway protection.)
9. Hemoglobin \<10mg/dl; WBC \<3,500.
10. History of non-compliance with treatment and office visits.
11. Thymectomy within 12 months before randomization.
12. Concurrent medical condition that would pose an unacceptable risk from immunosuppression, including a positive skin test for tuberculosis (PPD), unless the patient has previously received appropriate treatment.

Primary outcomes:
measure: QMGS
Secondary outcomes:
measure: Multiple
Other outcomes:
Locations:
Study officials:
affiliation: Duke University
name: Donald B Sanders, MD
role: PRINCIPAL_INVESTIGATOR
References: