Clinical trial NCT03105102: A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
Official title: A Multicenter, Randomized, Double-Blind, Placebo Controlled 52-Week Maintenance and an Open-Label Extension Study of the Efficacy and Safety of Risankizumab in Subjects With Crohn's Disease
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Crohn's Disease
Keywords: Risankizumab
ABBV-066
BI 655066
SKYRIZI
Crohn's Disease (CD)
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2017-04-07
Enrollment: 1336
Sex: ALL
Minimum age (years): 16
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study consists of 4 sub-studies, as follows:

* Sub-study 1 (Randomized, double-blind, placebo controlled study) to evaluate the efficacy and safety of risankizumab versus placebo as maintenance therapy in participants with moderately to severely active Crohn's disease (CD) who responded to intravenous risankizumab induction treatment in Study M16-006 or Study M15-991;
* Sub-study 2 (Randomized, exploratory maintenance study) to evaluate the efficacy and safety of two different dosing regimens for risankizumab as maintenance therapy in participants who responded to induction treatment in Study M16-006 or Study M15-991;
* Sub-study 3 (Open-label, long-term extension study) to evaluate long-term safety of risankizumab in participants who completed Sub-study 1, Sub-study 2, another AbbVie risankizumab Crohn's disease study, or participants who responded to induction treatment in Study M16-006 or Study M15-991 with no final endoscopy due to the Covid-19 pandemic. Additional objectives are to further investigate long-term efficacy and tolerability of risankizumab;
* Sub-study 4 (Open-label On Body Injector (OBI) administration and long-term extension study) to evaluate patient-reported outcomes, efficacy, safety, tolerability, and pharmacokinetics of risankizumab administered via OBI in participants who are receiving maintenance treatment with risankizumab.
* OL CTE to ensure uninterrupted care in accordance with local regulations until risankizumab is commercially available for participants who completed Sub-study 3, Sub-study 4.


Eligibility criteria: Inclusion Criteria:

* Participants who have entered and completed Study M16-006 or Study M15-991 or other AbbVie risankizumab Crohn's disease study.
* Participants have completed the study M16-006 or M15-991 and have achieved clinical response.
* Sub-Study 4:

  * Participants receiving maintenance treatment in Sub-study 3 and willing to comply with the requirements of Sub-study 4, including self-administration of sub-cutaneous injections using the on-body injector (OBI).
  * Participant has received at least 16 weeks of stable dosing with risankizumab in Sub-study 3 (i.e., no rescue within 16 weeks and participant has surpassed the 72-week mark).

Exclusion Criteria:

* Participants should not be enrolled in Study M16-000 with high grade colonic dysplasia or colon cancer identified during Study M15-991, Study M16-006 or another AbbVie risankizumab Crohn's disease study if the final endoscopy was performed prior to enter Study M16-000 OR is considered by the Investigator, for any reason, to be an unsuitable candidate for the study.
* Participant who has a known hypersensitivity to risankizumab or the excipients of any of the study drugs or the ingredients of Chinese hamster ovary (CHO), OR had an adverse event (AE) during Studies M16-006, M15-991 or another AbbVie risankizumab Crohn's disease study that in the Investigator's judgment makes the participant unsuitable for this study.
* Participant is not in compliance with prior and concomitant medication requirements throughout Studies M16-006, M15-991 or another AbbVie risankizumab Crohn's disease study.
* Confirmed positive urine pregnancy test at the Final Visit of Study M16-006, Study M15-991 or another AbbVie risankizumab Crohn's disease study.
* Have a known history of lymphoproliferative disease, including lymphoma, or signs and symptoms suggestive of possible lymphoproliferative disease, such as lymphadenopathy and/or splenomegaly.
* Any active or chronic recurring infections based on the Investigator's assessment makes the participant an unsuitable candidate for the study.

Primary outcomes:
measure: Sub-Study 1: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants With Endoscopic Response
timeFrame: Week 52
measure: Sub-Study 3: Number of Participants With Adverse Events
timeFrame: Up to Week 220
measure: Sub-Study 4: Percentage of Participants With an Observer Rating of Successful Participant Self Administration
timeFrame: Up to Week 16
measure: Sub-Study 4: Percentage of Participants who had no Potential Hazards
timeFrame: Up to Week 16
measure: Sub-Study 4: Percentage of Participants Rating of Acceptability Using Self-Injection Assessment Questionnaire (SIAQ) at Weeks 0, 8, 16
timeFrame: Up to Week 16
measure: Sub-Study 4: Percentage of Participants in CDAI Clinical Remission at Week 0, 16
timeFrame: Up to Week 16
Secondary outcomes:
measure: Sub-Study 1: Percentage of Participants With Clinical Remission
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants With CDAI Clinical Remission Among Participants With CDAI Clinical Remission in Week 0
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants With Ulcer-Free Endoscopy
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants With Endoscopic Remission
timeFrame: Week 52
measure: Sub-Study 1: Change From Baseline of Induction in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue)
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants Who Discontinued Corticosteroid Use for 90 Days and Achieved Clinical Remission in Participants Taking Steroids at Baseline
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants With Stool Frequency (SF) Remission
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants With Abdominal Pain (AP) Remission
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants With CDAI Clinical Remission and Endoscopic Response
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants With Deep Remission
timeFrame: Week 52
measure: Sub-Study 1: Percentage of Participants With Exposure Adjusted Occurrence of CD-related Hospitalizations From Week 0 Through Week 52
timeFrame: Up to Week 52
Other outcomes:
measure: Sub-Study 2: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
timeFrame: Week 52
measure: Sub-Study 2: Percentage of Participants With Endoscopic Response
timeFrame: Week 52
measure: Sub-Study 2: Percentage of Participants With Exposure Adjusted Occurrence of CD-related Hospitalizations From Week 0 Through Week 52
timeFrame: Up to Week 52
Locations:
city: Mesa
country: United States
facility: Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211884
state: Arizona
city: Phoenix
country: United States
facility: Phoenix VA Health Care System /ID# 162264
state: Arizona
city: Tucson
country: United States
facility: University of Arizona /ID# 158502
state: Arizona
city: Little Rock
country: United States
facility: Atria Clinical Research /ID# 164505
state: Arkansas
city: Coronado
country: United States
facility: Southern California Res. Ctr. /ID# 211991
state: California
city: Huntington Beach
country: United States
facility: Duplicate_Newport Huntington Medical Group /ID# 213035
state: California
city: La Jolla
country: United States
facility: UC San Diego Health Systems /ID# 155555
state: California
city: Los Alamitos
country: United States
facility: United Medical Doctors /ID# 207888
state: California
city: Los Angeles
country: United States
facility: TLC Clinical Research Inc /ID# 212719
state: California
city: Los Angeles
country: United States
facility: Gastrointestinal Biosciences Clinical Trials, LLC /ID# 162657
state: California
city: Murrieta
country: United States
facility: United Medical Doctors - Murrieta /ID# 158300
state: California
city: San Francisco
country: United States
facility: University of California San Francisco - Mission Bay /ID# 157127
state: California
city: West Hollywood
country: United States
facility: Duplicate_Cedars-Sinai Medical Center-West Hollywood /ID# 163839
state: California
city: Colorado Springs
country: United States
facility: Peak Gastroenterology Associates, PC /ID# 165843
state: Colorado
city: Lone Tree
country: United States
facility: Rocky Mountain Pediatric Gastroenterology /ID# 207170
state: Colorado
city: Danbury
country: United States
facility: Duplicate_Western Connecticut Medical Group /ID# 165879
state: Connecticut
city: Brandon
country: United States
facility: Brandon Premier Health Care, PA/Gulf Coast Research Group, LLC /ID# 162262
state: Florida
city: Clermont
country: United States
facility: South Lake Pain Institute, Inc /ID# 162808
state: Florida
city: DeBary
country: United States
facility: Omega Research Maitland, LLC /ID# 171082
state: Florida
city: Doral
country: United States
facility: Universal Axon Clinical Research /ID# 165428
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research - Inverness /ID# 159408
state: Florida
city: Kissimmee
country: United States
facility: SIH Research Mumtaz, Inc /ID# 163083
state: Florida
city: Lighthouse Point
country: United States
facility: Alliance Medical Research /ID# 163837
state: Florida
city: Maitland
country: United States
facility: Cfagi Llc /Id# 202479
state: Florida
city: Miami
country: United States
facility: Sylvester Comprehensive Cancer Center /ID# 155007
state: Florida
city: Miami
country: United States
facility: Coral Research Clinic /ID# 158456
state: Florida
city: Miami
country: United States
facility: South Florida Research Ph I-IV, Inc. /ID# 161832
state: Florida
city: Naples
country: United States
facility: Gastroenterology Group Naples /ID# 165204
state: Florida
city: New Port Richey
country: United States
facility: Advanced Research Institute, Inc /ID# 161966
state: Florida
city: Orlando
country: United States
facility: Endoscopic Research, Inc. /ID# 205906
state: Florida
city: Palmetto Bay
country: United States
facility: IMIC Inc. Medical Research /ID# 154942
state: Florida
city: Tampa
country: United States
facility: Clinical Research of West Florida, Inc /ID# 205865
state: Florida
city: Tampa
country: United States
facility: Clinical Research of West Florida, Inc /ID# 208125
state: Florida
city: Atlanta
country: United States
facility: Atlanta Gastro Assoc /ID# 154724
state: Georgia
city: Macon
country: United States
facility: Gastroenterology Associates of Central Georgia, LLC /ID# 154850
state: Georgia
city: Chicago
country: United States
facility: Duplicate_Northwestern University /ID# 158261
state: Illinois
city: Chicago
country: United States
facility: The University of Chicago Medical Center /ID# 157124
state: Illinois
city: Evanston
country: United States
facility: NorthShore University HealthSystem /ID# 158265
state: Illinois
city: Oak Lawn
country: United States
facility: Southwest Gastroenterology /ID# 164781
state: Illinois
city: Topeka
country: United States
facility: Cotton O'Neil Clinical Research Center, Digestive Health /ID# 154722
state: Kansas
city: Lexington
country: United States
facility: Duplicate_University of Kentucky Chandler Medical Center /ID# 157120
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville Hospital /ID# 210525
state: Kentucky
city: Baton Rouge
country: United States
facility: GI Alliance /ID# 161963
state: Louisiana
city: Houma
country: United States
facility: Houma Digestive Health Special /ID# 158264
state: Louisiana
city: New Orleans
country: United States
facility: Delricht Research /ID# 206644
state: Louisiana
city: New Orleans
country: United States
facility: Nola Research Works, LLC /ID# 161317
state: Louisiana
city: Shreveport
country: United States
facility: Louisiana Research Center, LLC /ID# 162237
state: Louisiana
city: Chevy Chase
country: United States
facility: Metropolitan Gastroenterology Group - Chevy Chase /ID# 154832
state: Maryland
city: Columbia
country: United States
facility: Gastro Center of Maryland /ID# 165001
state: Maryland
city: Ann Arbor
country: United States
facility: University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 157126
state: Michigan
city: Chesterfield
country: United States
facility: Clin Res Inst of Michigan, LLC /ID# 169179
state: Michigan
city: Troy
country: United States
facility: Center for Digestive Health /ID# 154683
state: Michigan
city: Wyoming
country: United States
facility: Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 161313
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic - Rochester /ID# 163086
state: Minnesota
city: Saint Louis
country: United States
facility: St. Louis University /ID# 161883
state: Missouri
city: Omaha
country: United States
facility: University of Nebraska Medical Center /ID# 210058
state: Nebraska
city: Las Vegas
country: United States
facility: Vector Clinical Trials /ID# 160170
state: Nevada
city: Las Vegas
country: United States
facility: Revival Research Institute, Inc /ID# 210985
state: Nevada
city: Brooklyn
country: United States
facility: NY Scientific /ID# 158294
state: New York
city: Burnt Hills
country: United States
facility: Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 213447
state: New York
city: Fresh Meadows
country: United States
facility: Intercity Advanced Gastroentertology Center /ID# 215205
state: New York
city: Great Neck
country: United States
facility: Duplicate_Northwell Health Division of Gastroenterology at Great Neck /ID# 168738
state: New York
city: Lake Success
country: United States
facility: NYU Langone Long Island Clinical Research Associates /ID# 154829
state: New York
city: New Hyde Park
country: United States
facility: Digestive Disease Care /ID# 211777
state: New York
city: New York
country: United States
facility: NYU Langone Medical Center /ID# 160169
state: New York
city: New York
country: United States
facility: Weill Cornell Medicine /ID# 165878
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai /ID# 165612
state: New York
city: New York
country: United States
facility: Columbia Univ Medical Center /ID# 161899
state: New York
city: New York
country: United States
facility: Lenox Hill Hospital /ID# 168467
state: New York
city: North Massapequa
country: United States
facility: Duplicate_DiGiovanna Institute for Medical Education & Research /ID# 171126
state: New York
city: Chapel Hill
country: United States
facility: Univ NC Chapel Hill /ID# 154833
state: North Carolina
city: Charlotte
country: United States
facility: Atrium Health Carolinas Medical Center /ID# 158428
state: North Carolina
city: Raleigh
country: United States
facility: Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154873
state: North Carolina
city: Fargo
country: United States
facility: Plains Clinical Research Center, LLC /ID# 169718
state: North Dakota
city: Cincinnati
country: United States
facility: Tri-State Endoscopy Center /ID# 154927
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Main Campus /ID# 209226
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University /ID# 164708
state: Ohio
city: Columbus
country: United States
facility: Optimed Research, Ltd. /ID# 167887
state: Ohio
city: Dayton
country: United States
facility: Hometown Urgent Care and Resea /ID# 170464
state: Ohio
city: Mentor
country: United States
facility: Great Lakes Gastroenterology Research, LLC /ID# 201770
state: Ohio
city: Oklahoma City
country: United States
facility: Hightower Clinical /ID# 211993
state: Oklahoma
city: Oklahoma City
country: United States
facility: Digestive Disease Specialists /ID# 170775
state: Oklahoma
city: Tulsa
country: United States
facility: Adult Gastroenterology Associates - Gen 1 Research /ID# 208864
state: Oklahoma
city: Pittsburgh
country: United States
facility: Children's Hospital of Pittsburgh of UPMC /ID# 212544
state: Pennsylvania
city: Wyomissing
country: United States
facility: Digestive Disease Associates, LTD /ID# 208297
state: Pennsylvania
city: Charleston
country: United States
facility: Medical University of South Carolina /ID# 212858
state: South Carolina
city: Greenville
country: United States
facility: Gastroenterology Associates, P.A. of Greenville /ID# 154904
state: South Carolina
city: Rapid City
country: United States
facility: Rapid City Medical Center - GI Research /ID# 163838
state: South Dakota
city: Cordova
country: United States
facility: Gastro One /ID# 154726
state: Tennessee
city: Johnson City
country: United States
facility: East Tennessee Research Institute /ID# 168739
state: Tennessee
city: Memphis
country: United States
facility: Clinical Neuroscience Solutions - Memphis /ID# 164180
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center /ID# 157121
state: Tennessee
city: Arlington
country: United States
facility: TX Clinical Research Institute /ID# 159404
state: Texas
city: Baytown
country: United States
facility: Inquest Clinical Research /ID# 165694
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209946
state: Texas
city: Cedar Park
country: United States
facility: GI Alliance /ID# 209797
state: Texas
city: Dallas
country: United States
facility: Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 159406
state: Texas
city: Garland
country: United States
facility: Duplicate_DHAT Research Institute /ID# 158208
state: Texas
city: Houston
country: United States
facility: Vilo Research Group Inc /ID# 207655
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine /ID# 158203
state: Texas
city: Houston
country: United States
facility: Centex Studies, Inc. - Houston /ID# 201219
state: Texas
city: San Antonio
country: United States
facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 161323
state: Texas
city: San Antonio
country: United States
facility: Southern Star Research Institute, LLC /ID# 168773
state: Texas
city: Temple
country: United States
facility: Baylor Scott & White Center for Diagnostic Medicine /ID# 204131
state: Texas
city: Tyler
country: United States
facility: Tyler Research Institute, LLC /ID# 166797
state: Texas
city: Victoria
country: United States
facility: Gastro Health & Nutrition - Victoria /ID# 164290
state: Texas
city: Ogden
country: United States
facility: Advanced Research Institute /ID# 154907
state: Utah
city: West Jordan
country: United States
facility: Velocity Clinical Research - Salt Lake City /ID# 161778
state: Utah
city: Richmond
country: United States
facility: Richmond VA Medical Center /ID# 159988
state: Virginia
city: Seattle
country: United States
facility: Duplicate_Virginia Mason Medical Center /ID# 155556
state: Washington
city: Morgantown
country: United States
facility: West Virginia University Hospitals /ID# 167941
state: West Virginia
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Hospital Britanico de Buenos Aires /ID# 168077
state: Ciudad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Cemic /Id# 168078
state: Ciudad Autonoma De Buenos Aires
city: Rosario
country: Argentina
facility: Hospital Provincial del Centenario /ID# 170886
state: Santa Fe
city: Cordoba
country: Argentina
facility: Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 168076
city: South Brisbane
country: Australia
facility: Mater Misericordiae Limited /ID# 167220
state: Queensland
city: Southport
country: Australia
facility: Griffith University /ID# 212635
state: Queensland
city: Elizabeth Vale
country: Australia
facility: Lyell McEwin Hospital /ID# 212215
state: South Australia
city: Camberwell
country: Australia
facility: Emeritus Research /ID# 213512
state: Victoria
city: Sankt Poelten
country: Austria
facility: Universitaetsklinikum St. Poelten /ID# 166424
state: Niederoesterreich
city: Graz
country: Austria
facility: Medizinische Universitaet Graz /ID# 158140
state: Steiermark
city: Vienna
country: Austria
facility: Krankenhaus der Barmherzigen Brueder Wien /ID# 212060
state: Wien
city: Vienna
country: Austria
facility: Medizinische Universitaet Wien /ID# 158141
state: Wien
city: Grodno
country: Belarus
facility: Grodno city clinical hospital #2 /ID# 205113
state: Grodnenskaya Oblast
city: Gomel
country: Belarus
facility: Gomel Regional Clinical Hospital /ID# 205112
city: Витебск
country: Belarus
facility: Vitebsk Regional Advanced Clin /ID# 206778
city: Bonheiden
country: Belgium
facility: Imelda Ziekenhuis /ID# 157403
state: Antwerpen
city: Mechelen
country: Belgium
facility: AZ Sint-Maarten /ID# 212876
state: Antwerpen
city: Merksem
country: Belgium
facility: ZAS Palfijn /ID# 212877
state: Antwerpen
city: Anderlecht
country: Belgium
facility: Universite Libre de Bruxelles - Hopital Erasme /ID# 157408
state: Bruxelles-Capitale
city: Woluwe-Saint-Lambert
country: Belgium
facility: Cliniques Universitaires UCL Saint-Luc /ID# 157406
state: Bruxelles-Capitale
city: Yvoir
country: Belgium
facility: Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 157412
state: Namur
city: Gent
country: Belgium
facility: UZ Gent /ID# 157405
state: Oost-Vlaanderen
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven /ID# 157407
state: Vlaams-Brabant
city: Roeselare
country: Belgium
facility: AZ-Delta /ID# 157402
state: West-Vlaanderen
city: Gent
country: Belgium
facility: AZ Maria Middelares /ID# 213532
city: Kortrijk
country: Belgium
facility: AZ Groeninge /ID# 211513
city: Liege
country: Belgium
facility: CHU de Liege /ID# 157409
city: Liege
country: Belgium
facility: Groupe Sante CHC - Clinique du MontLegia /ID# 157404
city: Banja Luka
country: Bosnia and Herzegovina
facility: Klinicki centar Banja Luka /ID# 164513
state: Republika Srpska
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center University of Sarajevo /ID# 165139
city: Pleven
country: Bulgaria
facility: UMHAT Dr Georgi Stranski EAD /ID# 203976
city: Plovdiv
country: Bulgaria
facility: Umbal Kaspela /ID# 165700
city: Sofia
country: Bulgaria
facility: 2nd Mhat /ID# 165702
city: Sofia
country: Bulgaria
facility: Tokuda Hospital Sofia /ID# 165701
city: Sofia
country: Bulgaria
facility: UMHAT Sveti Ivan Rilski /ID# 204815
city: Sofia
country: Bulgaria
facility: Duplicate_UMHAT Tsaritsa Joanna - ISUL /ID# 211242
city: Stara Zagora
country: Bulgaria
facility: MHAT Trakia /ID# 201668
city: Calgary
country: Canada
facility: University of Calgary /ID# 157155
state: Alberta
city: Edmonton
country: Canada
facility: Allen Whey Khye Lim Professional Corporation /ID# 169763
state: Alberta
city: Edmonton
country: Canada
facility: University of Alberta Hospital /ID# 157099
state: Alberta
city: Edmonton
country: Canada
facility: Covenant Health /ID# 161632
state: Alberta
city: New Westminster
country: Canada
facility: Fraser Clinical Trials Inc /ID# 159055
state: British Columbia
city: Vancouver
country: Canada
facility: (G.I.R.I.) GI Research Institute Foundation /ID# 157096
state: British Columbia
city: Victoria
country: Canada
facility: Percuro Clinical Research, Ltd /ID# 161631
state: British Columbia
city: Halifax
country: Canada
facility: QEII - Health Sciences Centre /ID# 157088
state: Nova Scotia
city: Halifax
country: Canada
facility: IWK Health Center /ID# 165905
state: Nova Scotia
city: Hamilton
country: Canada
facility: Hamilton Health Sciences - McMaster University Medical Centre /ID# 157184
state: Ontario
city: London
country: Canada
facility: London Health Sciences Center- University Hospital /ID# 157161
state: Ontario
city: North Bay
country: Canada
facility: Scott Shulman Medicine Professional Corporation /ID# 165906
state: Ontario
city: Sudbury
country: Canada
facility: Medicor Research Inc /ID# 157150
state: Ontario
city: Toronto
country: Canada
facility: Mount Sinai Hospital /ID# 169764
state: Ontario
city: Vaughan
country: Canada
facility: Toronto Digestive Disease Associates /ID# 157158
state: Ontario
city: Lévis
country: Canada
facility: Hotel Dieu de Levis /ID# 214377
state: Quebec
city: Montreal
country: Canada
facility: CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 159056
state: Quebec
city: Montreal
country: Canada
facility: Montreal General Hospital- McGill University Health Center /ID# 157085
state: Quebec
city: Greenfield Park
country: Canada
facility: CISSS de la Monteregie Centre - Hopital Charles Le Moyne /ID# 161630
city: Concepción
country: Chile
facility: Hospital Guillermo Grant Benavente de Concepción /ID# 210760
state: Bio-Bio
city: Talcahuano
country: Chile
facility: Hospital Las Higueras /ID# 167092
state: Bio-Bio
city: Santiago
country: Chile
facility: Complejo Asistencial Dr. Sotero del Rio /ID# 169384
state: Region Metropolitana De Santiago
city: Santiago
country: Chile
facility: Servicio de Salud Occidente Hospital San Juan de Dios /ID# 171122
state: Region Metropolitana Santiago
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital /ID# 212949
state: Guangdong
city: Guangzhou
country: China
facility: The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 210784
state: Guangdong
city: Shijiazhuang
country: China
facility: The Second Hospital of Hebei Medical University /ID# 212738
state: Hebei
city: Wuhan
country: China
facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 211039
state: Hubei
city: Wuhan
country: China
facility: Tongji Hospital Tongji Medical College of HUST /ID# 210858
state: Hubei
city: Wuhan
country: China
facility: Renmin Hospital of Wuhan University /ID# 214874
state: Hubei
city: Changsha
country: China
facility: The Second Xiangya Hospital of Central South University /ID# 211700
state: Hunan
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University /ID# 211036
state: Jiangxi
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210840
state: Shanghai
city: Shanghai
country: China
facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210705
state: Shanghai
city: Shanghai
country: China
facility: Shanghai East Hospital /ID# 212684
state: Shanghai
city: Chengdu
country: China
facility: West China Hospital, Sichuan University /ID# 210890
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital /ID# 210926
state: Tianjin
city: Hangzhou
country: China
facility: The second affiliated hospital of Zhejiang University school of medicine /ID# 210724
state: Zhejiang
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 210625
state: Zhejiang
city: Jinhua
country: China
facility: Jinhua Municipal Central Hospital /ID# 215628
state: Zhejiang
city: Medellin
country: Colombia
facility: Instituto de Coloproctologia /ID# 158743
state: Antioquia
city: Medellin
country: Colombia
facility: Hospital Universitario San Vic /ID# 171486
state: Antioquia
city: Medellín
country: Colombia
facility: Hospital Pablo Tobón Uribe /ID# 158730
state: Antioquia
city: Bogota
country: Colombia
facility: Hospital Univ San Ignacio /ID# 158734
state: Cundinamarca
city: Zagreb
country: Croatia
facility: Klinicka bolnica Dubrava Zagreb /ID# 157560
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Sestre milosrdnice /ID# 157728
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Zagreb /ID# 157561
state: Grad Zagreb
city: Osijek
country: Croatia
facility: Poliklinika Borzan d.o.o. /ID# 157559
state: Osjecko-baranjska Zupanija
city: Split
country: Croatia
facility: Klinicki Bolnicki Centar (KBC) Split /ID# 157562
state: Splitsko-dalmatinska Zupanija
city: Zadar
country: Croatia
facility: Zadar General Hospital /ID# 157563
city: Prague 4
country: Czechia
facility: Duplicate_Institut klinicke a experimentalni mediciny (IKEM) /ID# 165465
state: Praha 4
city: Prague
country: Czechia
facility: Iscare Klinické Centrum /ID# 225794
state: Praha 9
city: Hradec Kralove
country: Czechia
facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 163225
city: Pardubice
country: Czechia
facility: Nemocnice Pardubickeho kraje, a.s. /ID# 163226
city: Praha
country: Czechia
facility: Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211306
city: Praha
country: Czechia
facility: Axon Clinical, s.r.o. /ID# 163223
city: Praha
country: Czechia
facility: Fakultni Thomayerova nemocnice /ID# 162941
city: Praha
country: Czechia
facility: ResTrial s.r.o. /ID# 211078
city: Praha
country: Czechia
facility: Nemocnice Horovice - NH Hospital a.s /ID# 211077
city: Hvidovre
country: Denmark
facility: Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 155530
state: Hovedstaden
city: Aarhus
country: Denmark
facility: Aarhus Universitetshospital - Skejby /ID# 155664
state: Midtjylland
city: Roskilde
country: Denmark
facility: Roskilde Sygehus /ID# 155532
state: Sjælland
city: Nyborg
country: Denmark
facility: Sygehusenheden Nyborg - OUH /ID# 161525
state: Syddanmark
city: Odense
country: Denmark
facility: Odense University Hospital /ID# 155531
state: Syddanmark
city: Alexandria
country: Egypt
facility: Alexandria University /ID# 157187
state: Al Iskandariyah
city: Alexandria
country: Egypt
facility: Alexandria University /ID# 164540
state: Al Iskandariyah
city: Al Sharqia
country: Egypt
facility: Zagazig University Hospitals /ID# 164539
city: Cairo
country: Egypt
facility: Clinical Research Center, Faculty of Medicine, Cairo university /ID# 157175
city: Cairo
country: Egypt
facility: National Hepatology and Tropical Medicine Research Institute /ID# 157874
city: Cairo
country: Egypt
facility: Duplicate_Internal Medicine Department, Faculty of Medicine, AinShams University /ID# 157506
city: Mustamäe Linnaosa
country: Estonia
facility: North Estonia Medical Centre /ID# 164326
state: Harjumaa
city: Tallinn
country: Estonia
facility: East Tallinn Central Hospital /ID# 157074
state: Harjumaa
city: Tallinn
country: Estonia
facility: West Tallinn Central Hospital /ID# 157075
state: Harjumaa
city: Nice
country: France
facility: Chu de Nice-Hopital Larchet Ii /Id# 162557
state: Alpes-Maritimes
city: Pessac CEDEX
country: France
facility: Centre Hospitalier Universitaire de Bordeaux /ID# 162558
state: Gironde
city: Montpellier Cedex 5
country: France
facility: CHU Montpellier - Hopital Saint Eloi /ID# 215147
state: Herault
city: Clichy
country: France
facility: Hopital Beaujon /ID# 166284
state: Ile-de-France
city: Neuilly Sur Seine
country: France
facility: Centre Medico Chirurgical Ambroise Pare Hartmann /ID# 249858
state: Ile-de-France
city: La Tronche
country: France
facility: Duplicate_CHU Grenoble - Hopital Michallon /ID# 212834
state: Isere
city: St-Priest-en-Jarez
country: France
facility: Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 162562
state: Loire
city: Vandoeuvre-les-Nancy
country: France
facility: CHRU Nancy - Hopitaux de Brabois /ID# 162561
state: Meurthe-et-Moselle
city: Lille
country: France
facility: CHRU Lille - Hopital Claude Huriez /ID# 162559
state: Nord
city: Pierre Benite CEDEX
country: France
facility: HCL - Hopital Lyon Sud /ID# 162560
state: Rhone
city: Amiens CEDEX 1
country: France
facility: CHU Amiens-Picardie Site Sud /ID# 165058
state: Somme
city: Rennes
country: France
facility: CHRU Pontchaillou /ID# 213209
city: Freiburg
country: Germany
facility: Universitaetsklinikum Freiburg /ID# 162030
state: Baden-Wuerttemberg
city: Heidelberg
country: Germany
facility: Praxis fuer Gastroenterologie /ID# 166150
state: Baden-Wuerttemberg
city: Mannheim
country: Germany
facility: Universitatsklinikum Mannheim /ID# 162031
state: Baden-Wuerttemberg
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm /ID# 164990
state: Baden-Wuerttemberg
city: Dachau
country: Germany
facility: Medizinisches Versorgunszentrum Dachau /ID# 211555
state: Bayern
city: Erlangen
country: Germany
facility: Universitaetsklinikum Erlangen /ID# 159343
state: Bayern
city: Frankfurt am Main
country: Germany
facility: Duplicate_Agaplesion Markus Krankenhaus /ID# 159345
state: Hessen
city: Frankfurt am Main
country: Germany
facility: Universitaetsklinikum Frankfurt /ID# 212979
state: Hessen
city: Lueneburg
country: Germany
facility: Klinikum Lueneburg /ID# 163678
state: Niedersachsen
city: Cologne
country: Germany
facility: Evangelisches Krankenhaus Kalk /ID# 212726
state: Nordrhein-Westfalen
city: Grevenbroich
country: Germany
facility: Praxiszentrum fuer Gastroenterologie /ID# 211966
state: Nordrhein-Westfalen
city: Köln
country: Germany
facility: Universitaetsklinikum Koeln /ID# 164989
state: Nordrhein-Westfalen
city: Minden
country: Germany
facility: Gastroenterologische Gemeinschaftspraxis Minden /ID# 162029
state: Nordrhein-Westfalen
city: Muenster
country: Germany
facility: Universitaetsklinikum Muenster /ID# 159344
state: Nordrhein-Westfalen
city: Saarbrücken
country: Germany
facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210528
state: Saarland
city: Leipzig
country: Germany
facility: Eugastro /ID# 212078
state: Sachsen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159349
state: Schleswig-Holstein
city: Jena
country: Germany
facility: Universitaetsklinikum Jena /ID# 159351
state: Thueringen
city: Berlin-Zehlendorf
country: Germany
facility: Krankenhaus Waldfriede /ID# 212727
city: Berlin
country: Germany
facility: Duplicate_Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212220
city: Berlin
country: Germany
facility: Duplicate_Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212894
city: Berlin
country: Germany
facility: Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211974
city: Berlin
country: Germany
facility: MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159350
city: Berlin
country: Germany
facility: DRK Kliniken Berlin Westend /ID# 166151
city: Braunschweig
country: Germany
facility: Stadtisches Klinikum Braunschweig /ID# 163680
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover /ID# 162032
city: Magdeburg
country: Germany
facility: Universitaetsklinikum Magdeburg /ID# 211843
city: Regensburg
country: Germany
facility: Universitaetsklinikum Regensburg /ID# 163813
city: Athens
country: Greece
facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 170914
state: Attiki
city: Nikaia
country: Greece
facility: General Hospital of Nikaia-Piraeus "Agios Panteleimon" /ID# 157424
state: Attiki
city: Piraeus
country: Greece
facility: Tzaneio general hospital of Piraeus /ID# 206443
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 157422
state: Kriti
city: Athens
country: Greece
facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157423
city: Ioannina
country: Greece
facility: University General Hospital of Ioannina /ID# 157420
city: Thessaloniki
country: Greece
facility: Theageneio Anticancer Hospital /ID# 163897
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital /ID# 163923
city: Hong Kong
country: Hong Kong
facility: Tuen Mun Hospital /ID# 163905
city: Beaumont
country: Ireland
facility: Duplicate_Beaumont Hospital /ID# 157543
state: Dublin
city: Elm Park
country: Ireland
facility: St Vincent's University Hospital /ID# 157540
state: Dublin
city: Galway
country: Ireland
facility: University Hospital Galway /ID# 157541
city: Ashkelon
country: Israel
facility: The Edith Wolfson Medical Center /ID# 217331
state: HaDarom
city: Be'er Sheva
country: Israel
facility: Soroka University Medical Center /ID# 157794
state: HaDarom
city: Ramat Gan
country: Israel
facility: The Chaim Sheba Medical Center /ID# 157793
state: Tel-Aviv
city: Ramat Gan
country: Israel
facility: The Chaim Sheba Medical Center /ID# 171069
state: Tel-Aviv
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 157792
state: Tel-Aviv
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center /ID# 163541
state: Yerushalayim
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center /ID# 171068
state: Yerushalayim
city: Jerusalem
country: Israel
facility: Hadassah Medical Center-Hebrew University /ID# 165914
state: Yerushalayim
city: Haifa
country: Israel
facility: Duplicate_Rambam Medical Center /ID# 171067
city: Torrette
country: Italy
facility: Duplicate_AOU Ospendali Riuniti di Ancona /ID# 162436
state: Ancona
city: Bologna
country: Italy
facility: IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 155643
state: Emilia-Romagna
city: Genoa
country: Italy
facility: Duplicate_Ospedale Policlinico San Martino /ID# 162439
state: Genova
city: Rozzano
country: Italy
facility: IRCCS Istituto Clinico Humanitas /ID# 155642
state: Lombardia
city: Milan
country: Italy
facility: ASST Fatebenefratelli Sacco /ID# 155639
state: Milano
city: Rho
country: Italy
facility: ASST Rhodense/Presidio Ospedaliero di Rho /ID# 212227
state: Milano
city: Rome
country: Italy
facility: Duplicate_Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 162438
state: Roma
city: Rome
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 158022
state: Roma
city: Rome
country: Italy
facility: Azienda Ospedaliera San Camillo Forlanini /ID# 155644
state: Roma
city: Rome
country: Italy
facility: Duplicate_Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 166912
state: Roma
city: Rome
country: Italy
facility: Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 155640
state: Roma
city: Florence
country: Italy
facility: Duplicate_Azienda Ospedaliera Univ. Meyer /ID# 167992
state: Toscana
city: Negrar
country: Italy
facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 161299
state: Verona
city: Catania
country: Italy
facility: Ospedale Cannizzaro /ID# 161300
city: Catanzaro
country: Italy
facility: Azienda Ospedaliero-Universitaria Renato Dulbecco /ID# 212016
city: Milano
country: Italy
facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 155641
city: Modena
country: Italy
facility: Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212028
city: Palermo
country: Italy
facility: Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 155645
city: Pavia
country: Italy
facility: Duplicate_Fondazione IRCCS Policlinico S. Matteo /ID# 212031
city: Nagakute
country: Japan
facility: Aichi Medical University Hospital /ID# 160097
state: Aichi
city: Nagoya shi
country: Japan
facility: Nagoya City University Hospital /ID# 160100
state: Aichi
city: Nagoya-shi
country: Japan
facility: Daido Clinic - Nagoya /ID# 211476
state: Aichi
city: Nagoya-shi
country: Japan
facility: Nagoya University Hospital /ID# 160116
state: Aichi
city: Toyoake-shi
country: Japan
facility: Duplicate_Fujita Health University Hospital /ID# 163234
state: Aichi
city: Abiko-shi
country: Japan
facility: Tokatsu Tsujinaka Hospital /ID# 163352
state: Chiba
city: Chiba-shi
country: Japan
facility: Duplicate_Chiba University Hospital /ID# 217533
state: Chiba
city: Kashiwa-shi
country: Japan
facility: Tsujinaka Hospital Kashiwanoha /ID# 213848
state: Chiba
city: Kashiwa-shi
country: Japan
facility: The Jikei University Kashiwa Hospital /ID# 200030
state: Chiba
city: Sakura-shi
country: Japan
facility: Toho University Sakura Medical Center /ID# 160099
state: Chiba
city: Fukuoka-shi
country: Japan
facility: Fukuoka University Hospital /ID# 217793
state: Fukuoka
city: Kurume-shi
country: Japan
facility: Kurume University Hospital /ID# 160106
state: Fukuoka
city: Fukuyama-shi
country: Japan
facility: NHO Fukuyama Medical Center /ID# 163577
state: Hiroshima
city: Hiroshima-shi
country: Japan
facility: Hiroshima University Hospital /ID# 160109
state: Hiroshima
city: Asahikawa-shi
country: Japan
facility: Asahikawa Medical University Hospital /ID# 162848
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Tokushukai Hospital /ID# 213492
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 160096
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Medical University Hospital /ID# 163056
state: Hokkaido
city: Nishinomiya-shi
country: Japan
facility: Nishinomiya Municipal Central Hospital /ID# 210103
state: Hyogo
city: Nishinomiya-shi
country: Japan
facility: Hyogo Medical University Hospital /ID# 160107
state: Hyogo
city: Higashiibaraki-gun
country: Japan
facility: NHO Mito Medical Center /ID# 160092
state: Ibaraki
city: Kanazawa-shi
country: Japan
facility: Kanazawa University Hospital /ID# 202258
state: Ishikawa
city: Kamakura-shi
country: Japan
facility: Gokeikai Ofuna Chuo Hospital /ID# 171066
state: Kanagawa
city: Sagamihara-shi
country: Japan
facility: Kitasato University Hospital /ID# 171065
state: Kanagawa
city: Yokohama shi
country: Japan
facility: Yokohama City University Medical Center /ID# 163907
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Duplicate_Yokohama Municipal Citizen's Hospital /ID# 207161
state: Kanagawa
city: Tsu-shi
country: Japan
facility: Mie University Hospital /ID# 203640
state: Mie
city: Yokkaichi-shi
country: Japan
facility: Yokkaichi Hazu Medical Center /ID# 163764
state: Mie
city: Sendai-shi
country: Japan
facility: Tohoku University Hospital /ID# 162847
state: Miyagi
city: Sendai-shi
country: Japan
facility: Tohoku Rosai Hospital /ID# 163229
state: Miyagi
city: Osaka-shi
country: Japan
facility: Osaka Metropolitan University Hospital /ID# 160117
state: Osaka
city: Kawagoe-shi
country: Japan
facility: Saitama Medical Center /ID# 160093
state: Saitama
city: Saitama-shi
country: Japan
facility: Tokitokai Tokito clinic /ID# 160110
state: Saitama
city: Otsu
country: Japan
facility: Shiga University of Medical Science Hospital /ID# 164025
state: Shiga
city: Hamamatsu-shi
country: Japan
facility: Hamamatsu University Hospital /ID# 205690
state: Shizuoka
city: Sunto-gun
country: Japan
facility: NHO Shizuoka Medical Center /ID# 163057
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Institute of Science Tokyo Hospital /ID# 160095
state: Tokyo
city: Hachioji-shi
country: Japan
facility: Tokai University Hachioji Hospital /ID# 160098
state: Tokyo
city: Minato-ku
country: Japan
facility: The Jikei University Hospital /ID# 163209
state: Tokyo
city: Minato-ku
country: Japan
facility: Kitasato University Kitasato Institute Hospital /ID# 160105
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Women's Medical University Hospital /ID# 205974
state: Tokyo
city: Wakayama-shi
country: Japan
facility: Wakayama Medical University Hospital /ID# 202561
state: Wakayama
city: Yamagata-shi
country: Japan
facility: Yamagata University Hospital /ID# 200159
state: Yamagata
city: Kofu-shi
country: Japan
facility: Yamanashi Prefectural Central Hospital /ID# 160094
state: Yamanashi
city: Mitaka
country: Japan
facility: Kyorin University - Mitaka Campus /ID# 160114
city: Busan
country: Korea, Republic of
facility: Inje University Haeundae Hospital /ID# 202518
state: Busan Gwang Yeogsi
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital /ID# 158695
state: Busan Gwang Yeogsi
city: Daejeon
country: Korea, Republic of
facility: The Catholic University of Korea, Daejeon St. Mary's Hospital /ID# 213554
state: Daejeon Gwang Yeogsi
city: Guri-si
country: Korea, Republic of
facility: Hanyang University Guri Hospital /ID# 158690
state: Gyeonggido
city: Seongnam si
country: Korea, Republic of
facility: Duplicate_CHA University Bundang Medical Center /ID# 158698
state: Gyeonggido
city: Suwon
country: Korea, Republic of
facility: The Catholic University Of Korea St. Vincent's Hospital /ID# 158693
state: Gyeonggido
city: Busan
country: Korea, Republic of
facility: Dong-A University Medical Center /ID# 158699
state: Gyeongsangnamdo
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital /ID# 158694
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center /ID# 158696
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center /ID# 158692
state: Seoul Teugbyeolsi
city: Daegu
country: Korea, Republic of
facility: Yeungnam University Medical Center /ID# 158691
city: Seoul
country: Korea, Republic of
facility: Yonsei University Health System Severance Hospital /ID# 158689
city: Riga
country: Latvia
facility: VCA Polyclinic Aura /ID# 159611
city: Riga
country: Latvia
facility: Pauls Stradins Clinical University Hospital /ID# 159612
city: Riga
country: Latvia
facility: Duplicate_Digestive Disease Center Gastro /ID# 163107
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 162583
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital Santaros Klinikos /ID# 162514
city: Division Pantai Barat Utara
country: Malaysia
facility: Queen Elizabeth Hospital /ID# 160664
state: Sabah
city: Kuala Lumpur
country: Malaysia
facility: Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 201363
state: Selangor
city: Kelantan
country: Malaysia
facility: Universiti Sains Malaysia /ID# 160666
city: Zapopan
country: Mexico
facility: Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 170734
state: Jalisco
city: Cuernavaca
country: Mexico
facility: JM Research SC /ID# 170729
state: Morelos
city: Merida
country: Mexico
facility: Unidad de Atencion Medica e Investigacion en Salud /ID# 170732
state: Yucatan
city: Del. Benito Juárez
country: Mexico
facility: Health Pharma Professional Research S.A de C.V /ID# 170730
city: Tilburg
country: Netherlands
facility: Elisabeth Tweesteden Ziekenhuis /ID# 163632
state: Noord-Brabant
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, locatie AMC /ID# 157956
state: Noord-Holland
city: Papatoetoe
country: New Zealand
facility: Aotearoa Clinical Trials /ID# 167226
state: Auckland
city: Christchurch
country: New Zealand
facility: Christchurch Hospital /ID# 167224
state: Canterbury
city: Otago
country: New Zealand
facility: Dunedin Hospital /ID# 167227
city: Wellington
country: New Zealand
facility: Duplicate_Wellington Hospital (Capital and Coast District Health Board) /ID# 167225
city: Gjettum
country: Norway
facility: Duplicate_Vestre viken - Baerum Sykehus /ID# 212996
state: Akershus
city: Nordbyhagen
country: Norway
facility: Akershus Universitetssykehus /ID# 169379
state: Akershus
city: Ålesund
country: Norway
facility: Helse More og Romsdal HF, Alesund sjukehus /ID# 212810
state: More Og Romsdal
city: Levanger
country: Norway
facility: Sykehuset Levanger Helse NT /ID# 201669
state: Nord-Trondelag
city: Wroclaw
country: Poland
facility: Planetmed Sp. z o.o. /ID# 202799
state: Dolnoslaskie
city: Torun
country: Poland
facility: Gastromed Sp. z o.o /ID# 212476
state: Kujawsko-pomorskie
city: Lodz
country: Poland
facility: Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212477
state: Lodzkie
city: Lublin
country: Poland
facility: 1 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 210940
state: Lubelskie
city: Lublin
country: Poland
facility: Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie /Id# 210941
state: Lubelskie
city: Warszawa
country: Poland
facility: Centrum Zdrowia MDM /ID# 163570
state: Mazowieckie
city: Warszawa
country: Poland
facility: Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 163582
state: Mazowieckie
city: Warszawa
country: Poland
facility: NZOZ Vivamed Jadwiga Miecz /ID# 202800
state: Mazowieckie
city: Warszawa
country: Poland
facility: Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213580
state: Mazowieckie
city: Rzeszow
country: Poland
facility: Centrum Medyczne Medyk /ID# 212891
state: Podkarpackie
city: Chojnice
country: Poland
facility: Centrum Medyczne LukaMed Joanna Luka /ID# 212478
state: Pomorskie
city: Tychy
country: Poland
facility: H-T Centrum Medyczne Endoterapia /ID# 212475
state: Slaskie
city: Olsztyn
country: Poland
facility: Wojewodzki Szpital Specjalistyczny /ID# 212474
state: Warminsko-mazurskie
city: Poznan
country: Poland
facility: Solumed Centrum Medyczne /ID# 163569
state: Wielkopolskie
city: Wroclaw
country: Poland
facility: Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclaw /ID# 212601
city: Guimaraes
country: Portugal
facility: Duplicate_Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 160737
state: Braga
city: Portimão
country: Portugal
facility: Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167752
state: Faro
city: Santa Maria Da Feira
country: Portugal
facility: Centro Hospitalar de Entre Douro e Vouga /ID# 160672
state: Porto
city: Almada
country: Portugal
facility: Duplicate_Hospital Garcia de Orta, EPE /ID# 160745
state: Setubal
city: Faro
country: Portugal
facility: Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 160713
city: Lisboa
country: Portugal
facility: Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167751
city: Lisboa
country: Portugal
facility: Unidade Local de Saude de Santa Maria, EPE /ID# 160692
city: Lisbon
country: Portugal
facility: Centro Hospitalar de Lisboa Central /ID# 160673
city: Loures
country: Portugal
facility: Hospital de Loures, E.P.E /ID# 207759
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 160693
city: Viseu
country: Portugal
facility: Centro Hosp de Tondela-Viseu /ID# 160699
city: Bucharest
country: Romania
facility: Fundeni Clinical Institute /ID# 170899
city: Cluj
country: Romania
facility: Tvm Med Serv Srl /Id# 170902
city: Timisoara
country: Romania
facility: Duplicate_Centrul Medical Tuculanu SRL /ID# 170903
city: Timișoara
country: Romania
facility: Cabinet Particular Policlinic Algomed /ID# 170900
city: Kemerovo
country: Russian Federation
facility: Kuzbass Regional Clinical Hospital /ID# 200962
state: Kemerovskaya Oblast
city: Novosibirsk
country: Russian Federation
facility: Novosibirski Gastrocenter /ID# 217552
state: Novosibirskaya Oblast
city: Perm
country: Russian Federation
facility: Duplicate_Perm state medical university n.a. E.A. Vagner /ID# 207439
state: Permskiy Kray
city: Saint Petersburg
country: Russian Federation
facility: Duplicate_St. Petersburg State Pediatric Medical University /ID# 211978
state: Sankt-Peterburg
city: Stavropol
country: Russian Federation
facility: Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 200970
state: Stavropol Skiy Kray
city: Tver
country: Russian Federation
facility: Tver Regional Clinical Hospital /ID# 206858
state: Tverskaya Oblast
city: Tyumen
country: Russian Federation
facility: Regional Clinical Hospital #1 /ID# 200973
state: Tyumenskaya Oblast
city: Izhevsk
country: Russian Federation
facility: Alliance Biomedical Ural Group /ID# 200972
state: Udmurtskaya Respublika
city: Moscow
country: Russian Federation
facility: National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 204808
city: St. Petersburg
country: Russian Federation
facility: City Clinical Hospital No. 31 /ID# 208872
city: Ulyanovsk
country: Russian Federation
facility: Ulyanovsk Regional Clinical Hospital /ID# 200964
city: Belgrade
country: Serbia
facility: Clinical Hosp Center Zvezdara /ID# 157052
state: Beograd
city: Belgrade
country: Serbia
facility: Military Medical Academy /ID# 157053
state: Beograd
city: Belgrade
country: Serbia
facility: University Children's Hospital 'Tirsova' /ID# 211482
state: Beograd
city: Belgrade
country: Serbia
facility: University Clinical Center Serbia /ID# 157047
state: Beograd
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212799
state: Beograd
city: Belgrade
country: Serbia
facility: Clin Hosp Ctr Bezanijska Kosa /ID# 157050
state: Beograd
city: Leskovac
country: Serbia
facility: General Hospital Leskovac /ID# 209575
state: Jablanicki Okrug
city: Kragujevac
country: Serbia
facility: Duplicate_University Clinical Center Kragujevac /ID# 157049
state: Sumadijski Okrug
city: Novi Sad
country: Serbia
facility: University Clinical Center Vojvodina /ID# 157046
city: Singapore
country: Singapore
facility: Gastroenterology and Liver Specialist Clinic /ID# 205741
state: Central Singapore
city: Singapore
country: Singapore
facility: National University Hospital /ID# 160667
city: Singapore
country: Singapore
facility: Singapore General Hospital /ID# 160668
city: Banska Bystrica
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156468
state: Banskobystricky Kraj
city: Nitra
country: Slovakia
facility: KM Management, spol. s.r.o. /ID# 206764
state: Nitriansky Kraj
city: Prešov
country: Slovakia
facility: Gastro I., s.r.o. /ID# 156469
state: Presovsky Kraj
city: Johannesburg
country: South Africa
facility: Clinresco Centers /ID# 163865
state: Gauteng
city: Johannesburg
country: South Africa
facility: Wits Clinical Research /ID# 158114
state: Gauteng
city: CAPE TOWN Milnerton
country: South Africa
facility: Spoke Research Inc /ID# 158116
state: Western Cape
city: Cape Town
country: South Africa
facility: Private Practice Dr MN Rajabally /ID# 163112
state: Western Cape
city: Ferrol
country: Spain
facility: Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157553
state: A Coruna
city: L'Hospitalet de Llobregat
country: Spain
facility: Hospital Universitari de Bellvitge /ID# 208207
state: Barcelona
city: Sabadell
country: Spain
facility: Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159237
state: Barcelona
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro - Majadahonda /ID# 157573
state: Madrid
city: Bilbao
country: Spain
facility: Hospital Universitario Basurto /ID# 205190
state: Vizcaya
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona /ID# 157552
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Maranon /ID# 161145
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 159235
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca /ID# 157558
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena /ID# 159967
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia /ID# 209700
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe /ID# 157556
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa /ID# 212525
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet /ID# 157557
city: Malmo
country: Sweden
facility: Skane University hospital /ID# 211745
state: Skane Lan
city: Solna
country: Sweden
facility: Karolinska University Hospital Solna /ID# 212025
state: Stockholms Lan
city: Stockholm
country: Sweden
facility: GHP Stockholm Gastro Center /ID# 211748
state: Stockholms Lan
city: Stockholm
country: Sweden
facility: Medicinkliniken, Gastroenheten /ID# 163744
state: Stockholms Lan
city: Stockholm
country: Sweden
facility: Danderyd Hospital /ID# 202138
state: Stockholms Lan
city: Gothenburg
country: Sweden
facility: Duplicate_Sahlgrenska University Hospital /ID# 163792
state: Vastra Gotalands Lan
city: Gothenburg
country: Sweden
facility: Duplicate_Sahlgrenska University Hospital /ID# 163797
state: Vastra Gotalands Lan
city: Basel Town
country: Switzerland
facility: Universitätsspital Basel /ID# 164554
state: Basel-Stadt
city: Zurich
country: Switzerland
facility: University Hospital Zurich /ID# 163536
state: Zuerich
city: Bern
country: Switzerland
facility: Inselspital, Universitaetsspital Bern /ID# 163535
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 162190
state: Taipei
city: Taichung
country: Taiwan
facility: China Medical University Hospital /ID# 160141
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital /ID# 160140
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital /ID# 160142
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hosp /ID# 212712
city: Lviv
country: Ukraine
facility: Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 165658
state: Lvivska Oblast
city: Vinnytsia
country: Ukraine
facility: CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 216474
state: Vinnytska Oblast
city: Vinnytsia
country: Ukraine
facility: ?linic Scientific Research Inst of Invalid Rehab ESM? M I Pyrogov VNMU /ID# 212000
state: Vinnytska Oblast
city: Lutsk
country: Ukraine
facility: ME Volyn Regional Clinical Hospital of Volyn Regional Council /ID# 206789
state: Volynska Oblast
city: Uzhgorod
country: Ukraine
facility: Transcarpathian Regional Clinical Hospital n.a. Andriy Novak /ID# 167960
state: Zakarpatska Oblast
city: Kharkiv
country: Ukraine
facility: Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 165657
city: Kherson
country: Ukraine
facility: Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 212399
city: Kyiv
country: Ukraine
facility: Kyiv City Clinical Hospital No.18 /ID# 162531
city: Kyiv
country: Ukraine
facility: Medical Center OK Clinic LLC, International Institute of Clinical Research /ID# 211998
city: Kyiv
country: Ukraine
facility: Communal Noncommercial Institution Consultative and Diagnostic Center of Desnian /ID# 165659
city: Kyiv
country: Ukraine
facility: Medical Center of LLC Medbud-Clinic /ID# 216998
city: Kyiv
country: Ukraine
facility: Kyiv Railway Clinical Hosp No.2 /ID# 217366
city: Cambridge
country: United Kingdom
facility: Addenbrooke's Hospital /ID# 158034
state: Cambridgeshire
city: Exeter
country: United Kingdom
facility: Duplicate_Royal Devon University Healthcare NHS Foundation Trust /ID# 157544
state: Devon
city: Hull
country: United Kingdom
facility: Hull University Teaching Hospitals NHS Trust /ID# 158761
state: East Riding Of Yorkshire
city: London
country: United Kingdom
facility: Barts Health NHS Trust /ID# 163713
state: Greater London
city: London
country: United Kingdom
facility: Guys and St Thomas NHS Foundation Trust /ID# 157546
state: Greater London
city: Oxford
country: United Kingdom
facility: Oxford University Hospitals NHS Foundation Trust /ID# 158036
state: Oxfordshire
city: Glasgow
country: United Kingdom
facility: NHS Greater Glasgow and Clyde /ID# 202568
state: Scotland
city: Chertsey
country: United Kingdom
facility: Ashford and St Peter's Hospitals NHS Foundation Trust /ID# 207936
state: Surrey
city: Leeds
country: United Kingdom
facility: Leeds Teaching Hospitals NHS Trust /ID# 157550
state: West Yorkshire
city: Barnsley
country: United Kingdom
facility: Barnsley Hospital NHS Foundation Trust /ID# 202773
city: Birmingham
country: United Kingdom
facility: University Hospitals Birmingham NHS Foundation Trust /ID# 157545
city: Edinburgh
country: United Kingdom
facility: NHS Lothian /ID# 207448
city: Huddersfield
country: United Kingdom
facility: Calderdale and Huddersfield NHS Foundation Trust /ID# 209570
city: London
country: United Kingdom
facility: King's College Hospital NHS Foundation Trust /ID# 158760
city: Newcastle upon Tyne
country: United Kingdom
facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163708
city: Salford
country: United Kingdom
facility: Northern Care Alliance NHS Group /ID# 207766
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References:
citation: Ferrante M, Panaccione R, Baert F, Bossuyt P, Colombel JF, Danese S, Dubinsky M, Feagan BG, Hisamatsu T, Lim A, Lindsay JO, Loftus EV Jr, Panes J, Peyrin-Biroulet L, Ran Z, Rubin DT, Sandborn WJ, Schreiber S, Neimark E, Song A, Kligys K, Pang Y, Pivorunas V, Berg S, Duan WR, Huang B, Kalabic J, Liao X, Robinson A, Wallace K, D'Haens G. Risankizumab as maintenance therapy for moderately to severely active Crohn's disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial. Lancet. 2022 May 28;399(10340):2031-2046. doi: 10.1016/S0140-6736(22)00466-4.