louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00951769: Algorithms in a Simulated Difficult Intubation Scenario
Official title: A Comparison of the Difficult Airway Society (UK) and Australian Patient Safety Foundation Crisis Algorithms for Difficult Intubation in a Simulated Difficult Intubation Scenario
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Airway Management
Lead sponsor: Liverpool University Hospitals NHS Foundation Trust
Sponsor class: OTHER_GOV
First posted: 2009-08-04
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Trainee anaesthetists in for 2 years of training

Brief summary: This is a non-human study, conducted in a simulation environment, with simulator manikins, and volunteers from anaesthesia. Trainees in their first 2 years of anaesthetics training will be randomised to a control group, a group following the Difficult Airway Society UK's Guidelines and the Australian Difficult Airway management algorithm. A simulated difficult airway will be created during the induction of anaesthesia. The investigators will examine adherence to guidelines, which would have been provided to participants before the experiment, as well as compare their performance with the guidelines.


Eligibility criteria: Inclusion Criteria:

* Anaesthetists in first 2 years of training

Exclusion Criteria:

* Those who decline invitation to participate

Primary outcomes:
measure: Time to safe oxygenation for manikin
timeFrame: Variable
Secondary outcomes:
Other outcomes:
Locations:
city: Liverpool
country: United Kingdom
facility: Cheshire & Merseyside Simulation Centre
state: Merseyside
Study officials:
affiliation: AINTREE HOSPITALS NHS TRUST
name: ARPAN GUHA, MD, FRCA
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05841069: Short and Prolonged Conservative Treatment in Patients With Adhesive Intestinal Obstruction
Official title: Multicenter Controlled Randomized Prospective Study of the Comparative Efficacy of Early and Delayed Surgical Interventions in Patients With Acute Adhesive Intestinal Obstruction
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Small Bowel Obstruction
Small Bowel Adhesion
Keywords: Acute adhesive intestinal obstruction, conservative treatment
Lead sponsor: North-Western State Medical University named after I.I.Mechnikov
Sponsor class: OTHER
First posted: 2023-05-03
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Multicenter controlled randomized prospective study
Primary purpose: TREATMENT

Brief summary: This study will compare the results of 24 h conservative treatment and N h conservative treatment of adhesive small bowel obstruction (where N = 72 h minus duration of intestinal obstruction).

Detailed description: Patients with acute adhesive intestinal obstruction, who dont need an emergency operation, will be given water insoluble contrast per os and randomized into two groups - early and delayed surgery. The first group will receive conservative treatment within no more than 24 h. Duration of non-operative treatment in second group will be 72 h minus duration of intestinal obstruction, based on the onset of symptoms. In both groups surgery will be performed if contrast will not reach colon in mentioned terms or clinical deterioration signs will appear. The results of 24 h conservative treatment and N h conservative treatment (where N = 72 h minus duration of intestinal obstruction) will be compared.

Eligibility criteria: Inclusion Criteria:

* patients with acute intestinal obstruction

Exclusion Criteria:

* pregnancy;
* peritonitis or strangulation, revealed during primary examination;
* early acute small bowel obstruction (presence of anamnestic surgical intervention within 6 month)

Primary outcomes:
measure: Non-operative treatment success
timeFrame: 72 hours
Secondary outcomes:
measure: Overall mortality
timeFrame: up to 30 days
measure: Postoperative complications
timeFrame: up to 30 days
measure: Resectional interventions
timeFrame: up to 30 days
Other outcomes:
Locations:
city: Saint Petersburg
country: Russian Federation
facility: 26 City Hospital
city: Saint Petersburg
country: Russian Federation
facility: North-Western State Medical University named after I. I. Mechnikov
city: Saint Petersburg
country: Russian Federation
facility: Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
city: Saint Petersburg
country: Russian Federation
facility: The City Hospital of the Holy Martyr Elizabeth
Study officials:
References:
Clinical trial NCT06946069: Immunomodulatory Effects of NB-UVB and Steroids in Vitiligo: A Study on CXCL11 and TEMRA Biomarkers
Official title: Expression of CXCL11 & TEMRA in Serum of Vitiligo Patients Treated With Narrow-band UVB
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Vitiligo
NB-UVB
Keywords: vitiligo
NB-UVB
CXCL11
TEMRA
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-04-27
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This is a two-arm, parallel-group randomized controlled trial (RCT).

Participants are randomly assigned (1:1 ratio) to one of two treatment arms:

NB-UVB monotherapy (control group).

NB-UVB + oral mini-pulse (OMP) steroids (intervention group).

Both groups receive simultaneous but distinct interventions for direct comparison.
Primary purpose: TREATMENT

Brief summary: this is a prospective, randomized controlled trial (RCT) investigating the immunological effects of narrowband UVB (NB-UVB) phototherapy-both as monotherapy and in combination with oral mini-pulse (OMP) steroids-in non-segmental vitiligo patients. The study evaluates changes in CXCL11 (a chemokine involved in T-cell recruitment) and TEMRA (terminally differentiated effector memory T cells re-expressing CD45RA) levels in serum before and after treatment.

Detailed description: Design:

Randomized controlled trial (RCT) with two parallel arms.

Duration: Six months (including baseline and follow-up assessments).

Setting: Outpatient dermatology clinic at Assiut University Hospital, Egypt.

Objectives:

Compare the immunomodulatory effects of NB-UVB alone vs. NB-UVB + OMP steroids in vitiligo patients.

Assess CXCL11 and TEMRA levels as potential biomarkers for disease activity and treatment response.

Evaluate clinical repigmentation using Vitiligo Extent Score (VES/VESplus).

Methodology:

40 patients with stable non-segmental vitiligo will be enrolled.

20 patients will undergo serum analysis for CXCL11 and TEMRA via ELISA.

Treatment arms:

NB-UVB monotherapy (twice weekly).

NB-UVB + OMP steroids (dexamethasone 2.5-3 mg/week).

Follow-up: Clinical and immunological assessments at baseline and 6 months.

Eligibility criteria: Inclusion Criteria:

Clinically diagnosed non-segmental vitiligo (stable for ≥3 months).

Fitzpatrick skin types III-V (common in the Egyptian population).

No recent systemic therapy for vitiligo (within the last 3 months).

Exclusion Criteria:

Photosensitivity disorders (e.g., lupus, porphyria).

Pregnancy or breastfeeding.

Active infections, malignancies, or immunosuppressive conditions.

History of hypertrophic scarring or melanoma.

Primary outcomes:
measure: Change in serum CXCL11 & TEMRA levels
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05917769: Comparison of Rocabado Approach Versus Postural Correction Exercises on Kinesiophobia and Interincisal Distance in Patients With Temporo-Mandibular Dysfunction
Official title: Comparison of Rocabado Approach Versus Postural Correction Exercises on Kinesiophobia and Interincisal Distance in Patients With Temporo-Mandibular Dysfunction
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Temporo-mandibular Dysfunction
Lead sponsor: Foundation University Islamabad
Sponsor class: OTHER
First posted: 2023-06-26
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Group A will receive conventional therapy for pain management and Rocabado exercises.

Group B will receive similar basic conventional therapy for pain management and perform posture correction exercises.
Primary purpose: TREATMENT

Brief summary: Temporo-mandibular dysfunction can cause pain and tenderness of jaw so posture correction exercises and Rocabado exercises will be performed targeting jaw opening and kinesiophobia.

Detailed description: Temporo-mandibular dysfunction refers to pain in area of Temporo-mandibular joint and masticatory muscles.Temporo-mandibular dysfunction can cause pain or tenderness of jaw and aching pain in and around the ear along with difficulty in chewing.In addition to these symptoms the Temporo-mandibular dysfunction results in impairment of mouth opening. So the posture correction exercises and Rocabado exercises will be used to treat patients which will target jaw opening and kinesiophobia.

Eligibility criteria: Inclusion Criteria:

* Male and female of 18 to 45 years with TMD pain for less than six months and pain rating at least moderate in severity
* Must not be receiving any treatment for TMD at the onset of the study (for example, an occlusal splint, prescription medication)
* Pain must have been of masticatory muscle origin
* Pain on jaw movement, headache and referred pain are suggestive of a muscular problems.

Exclusion Criteria:

* Patients of Systemic rheumatic disease \& Fibromyalgia
* Dental pathology
* Orofacial pain disorders
* Cervical structural pathology
* Current use of analgesics more than 3 days per week
* Current use of narcotics, hypnotic drugs, sedatives, or muscle relaxants

Primary outcomes:
measure: Mouth opening
timeFrame: 6 days
measure: Kinesiophobia
timeFrame: 6 days
Secondary outcomes:
Other outcomes:
Locations:
city: Islamabad
country: Pakistan
facility: Foundation University Islamabad
state: Federal
Study officials:
References:
Clinical trial NCT03975868: Risk Factors for Cut-out After Internal Fixation of Trochanteric Fractures in Elderly Subjects.
Official title: Risk Factors for Cut-out After Internal Fixation of Trochanteric Fractures in Elderly Subjects.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Proximal Femoral Fracture
Keywords: Cut-out
Gamma nail
Lag-screw
Tip-apex distance
Trochanteric fracture
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
First posted: 2019-06-05
Enrollment: 228
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients over 75 years old operated on for extracapsular proximal femoral fracture.

Brief summary: Proximal femoral fracture is associated with severe morbidity and mortality and high socioeconomic costs. The main mechanical complication of internal fixation in trochanteric fracture is lag-screw cut-out through the femoral head. Several factors are involved, but remain controversial. The aim of the present study was to determine risk factors for cut-out in internal fixation of extracapsular proximal femoral fracture.


Eligibility criteria: Inclusion Criteria:

* Patients over 75 years of age
* Operated on for extracapsular proximal femoral fracture
* After bodyheight fall

Exclusion Criteria:

* Intra-capsular fractures
* trochantero-diaphyseal fractures
* subtrochanteric fractures
* fractures involving pathological bone

Primary outcomes:
measure: Mechanical failure defined by varus fracture collapse and lag-screw cut-out with extrusion through the femoral head
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06358768: Post-Partum Haemorrhage (PPH) Improvement of Skills With Actor Simulations
Official title: Post-Partum Hemorrhage and Improvement in Technical Skills on Different Rules Using Actors Scenario
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: PPH - Postpartum Hemorrhage
Keywords: PPH
actor scenario
improve skills
improve teamwork reactions
Lead sponsor: G. d'Annunzio University
Sponsor class: OTHER
Collaborators: name: A.O. Ospedale Papa Giovanni XXIII
First posted: 2024-04-11
Enrollment: 50
Sex: ALL
Minimum age (years): 19
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: persons working in our hospitals

Brief summary: Pre test and post test questionnaire for evaluation of skills and teamwork capacities in PPH management

Detailed description: Obstetricians, midwives, anesthesiologists, surgical theatre nurses, and sanitary collaborators are enrolled voluntary in a teamwork (2 gynecologists, 2 midwives, 1 anesthesiologist, 1 surgical theatre nurse, and 1 sanitary collaborator) for managing a PPH scenario. 2 different teamworks will attend a frontal lecture of 30' and afterwards they attend a scenario with actors/facilitators (enrolled within ObGyn residents) or attend a scenario with a high-fidelity mannequin after a questionnaire indicating previous experiences and skills (at the end they accept video recording of the scenario and the use of data for scientific reasons). The teamwork is recorded and an extensive debriefing is conducted using the video records and a dataset indicating positive and negative approach. After they will answer a questionnaire indicating the use of this scenario and indicating how it is compared to reality. Personal approach to teamwork job is also described.

Eligibility criteria: Inclusion Criteria:

* personnel working in labour ward and surgical theatre
* Volunteers

Exclusion Criteria:

* none

Primary outcomes:
measure: teamwork
timeFrame: 1 month
measure: skills
timeFrame: 1 month
Secondary outcomes:
measure: scenario quality
timeFrame: 1 month
Other outcomes:
Locations:
city: Pescara
country: Italy
facility: Claudio Celentano
state: PE
city: Bergamo
country: Italy
facility: Ospedale Giovanni XXIII
Study officials:
affiliation: University d'annunzio
name: Claudio Celentano, MD
role: STUDY_CHAIR
affiliation: Ospedale Giovanni XXIII Bergamo
name: Luisa Patanè, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06163768: Effects of Insulin Resistance in Non-diabetic Acute Coronary Syndrome Patients
Official title: Effects of Insulin Resistance in Non-diabetic Acute Coronary Syndrome Patients by the Homeostasis Model Assessment Index (HOMA2-IR)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Insulin Resistance
Lead sponsor: University of Medicine and Pharmacy at Ho Chi Minh City
Sponsor class: OTHER
First posted: 2023-12-11
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Effects of insulin resistance in non-diabetic acute coronary syndrome patients by the homeostasis model assessment index (HOMA2-IR)

Detailed description: Help patients know about insulin resistance. If this condition persists for a long time, it will reduce the ability to produce insulin, thereby leading to increased blood sugar levels, causing type 2 diabetes. Helping doctors have a more general view, in order to come up with a strategy more effective monitoring and treatment, preventing diabetes and cardiovascular events.

Eligibility criteria: Inclusion Criteria:

* Control group The researcher collected samples from healthy people over 18 years old who came for a health check and were concluded to have good health at the Health Examination Department of University of Medicine and Pharmacy Hospital, Ho Chi Minh City. Not falling within the exclusion criteria and agreeing to participate in the study were included in the study.
* Researchers -All patients diagnosed with Acute coronary syndrome who were over 18 years old, met the inclusion criteria and did not have exclusion criteria, and agreed to participate in the study were included in the study.

Exclusion Criteria:

* Control group

  * Patients \< 18 years old.
  * History of heart disease or stroke
  * Exclude diabetic subjects
  * Exclude subjects at high risk of insulin resistance
* Researchers

  * Have diabetes or have previously been diagnosed with diabetes.
  * Patients \< 18 years old.
  * The patient does not participate in follow-up examinations and does not follow up treatment at the medical facility.
  * The patient died before reaching the hospital.
  * Patients with severe medical diseases: cirrhosis, cancer, obstructive pulmonary disease chronic obstructive pulmonary disease, chronic heart failure, severe kidney failure.

Primary outcomes:
measure: Model HOMA-IR
timeFrame: January 2026
Secondary outcomes:
Other outcomes:
Locations:
city: Ho Chi Minh City
country: Vietnam
facility: Medical and Pharmaceutical University Hospital
state: Five
Study officials:
References:
Clinical trial NCT04276168: Impact of Iron Stores on Wound Healing in Plastic Surgery
Official title: Impact of Iron Stores on Wound Healing in Plastic Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Healing Wound
Iron-deficiency
Surgical Wound
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2020-02-19
Enrollment: 400
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cohort of woman who had a scheduled bilateral breast reduction surgery without anemia

Brief summary: In breast reduction surgery, delayed wound healing may increase surgical site infections, cutaneous necrosis and may be related to psychological harm.Some risk factors have been identified : smoking, diabetes, overweight. A normal healing involve cellular and biochemical reactions in which iron plays an important role such as cellular respiration, redox reactions and regulation of genes involved in the cell cycle. This trial will study the relationship between iron stores and postoperative wound healing after bilateral breast reduction surgery in patients without preoperative anaemia.The primary outcome of this trial is the comparison of wound healing at post operative day 15, between patients with and without iron deficiency.


Eligibility criteria: Inclusion Criteria:

* age \>18 years
* female
* scheduled bilateral breast reduction surgery
* biological exams with ferritin and transferrin saturation coefficient taken the day before surgery
* No anemia : haemoglobin \>=12g/dL (preoperative biological assessment )
* if genetic disease of haemoglobin, haemoglobin between 10 and 12g/dL and no Anaemia by iron deficiency
* absence of clinical inflammatory syndrome (no clinical signs of infection or no fever)
* non-opposition of the patient to participate

Exclusion Criteria:

* Anaemia by iron deficiency

Primary outcomes:
measure: Proportion of good breast tissue healing on each breast
timeFrame: 15 days after surgery
Secondary outcomes:
measure: Evaluation of healing on the 16 points specific scale
timeFrame: 15 days after surgery
measure: Proportion of early complications
timeFrame: up to 15 days after surgery
measure: Proportion of closed drainage orifices
timeFrame: 15 days after surgery
measure: Correlation between serum ferritin levels before surgery and score on the healing scale
timeFrame: 15 days after surgery
measure: Intra-class correlation coefficient for the healing scale
timeFrame: 15 days after surgery
Other outcomes:
Locations:
city: Paris
country: France
facility: Saint Louis hospital
Study officials:
References:
Clinical trial NCT05360069: Linear Stapler Versus Circular Stapler in Esophagojejunostomy
Official title: Linear Stapler Versus Circular Stapler in Esophagojejunostomy for Patients With Gastric Cancer Underwent Laparoscopic Total Gastrectomy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Postoperative Complications
Operative Time
Hospital Costs
Keywords: laparoscopy
total gastrectomy
esophagojejunostomy
linear stapler
circular stapler
Lead sponsor: Nanchong Central Hospital
Sponsor class: OTHER_GOV
First posted: 2022-05-04
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: With the development of stapler devices, various methods of esophagojejunostomy after laparoscopic total gastrectomy were evoluated. Which stapler is more advantageous has not been determined. At present, the most commonly used is linear stapler or Circular stapler in esophagojejunostomy. However, there is still a lack of reliable evidence for the selection of the two staplers. The purpose of this study is to explore the advantages of linear staper versus circular stapler in esophagojejunostomy for patients with gastric cancer who underwent total gastrectomy.

Detailed description: With the development of stapler devices, various methods of esophagojejunostomy after laparoscopic total gastrectomy were evoluated. Which stapler is more advantageous has not been determined. At present, the most commonly used is linear stapler or Circular stapler in esophagojejunostomy. However, there is still a lack of reliable evidence for the selection of the two staplers. The purpose of this study is to explore the advantages of linear staper versus circular stapler in esophagojejunostomy for patients with Siewert classification type II and III gastric cancer who underwent total gastrectomy.

Eligibility criteria: Inclusion Criteria:

1. Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages.
2. Eastern Cooperative Oncology Group performance status of 0 or 1.
3. Adequate organ function.

Exclusion Criteria:

1. Patients had distant metastasis.
2. oesophageal invasion of more than 3 cm.
3. Borrmann type 4 or large (more than 8 cm) type 3 carcinoma.
4. Previous chemotherapy or radiation therapy for any other malignancies.

Primary outcomes:
measure: Surgical complication
timeFrame: 6 months
Secondary outcomes:
measure: Operation duration
timeFrame: 1 day
Other outcomes:
measure: hospitalization cost
timeFrame: 2 months
Locations:
city: Nanchong
country: China
facility: Yunhong Tian
state: Sichuan
Study officials:
References: