Clinical trial NCT03362450: Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features
Official title: Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fetal Volvulus
Midgut Volvulus
Keywords: Midgut volvulus
Fetal volvulus
Whirlpool sign
Pregnant women
Position of mesenteric vessels
Post natal surgery
Foetopathology if performed
Hydro-meconium level in the dilated loops
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2017-12-05
Enrollment: 13
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All pregnant women

Brief summary: Objective:

The small bowel volvulus is a rare cause of intestinal obstruction which may occur in utero and whose prenatal diagnosis is difficult.Sonographic signs are mainly indirect and non specific.The aim of this study is to present a retrospective analysis of prenatal sonographicfindings in fetal segmental midgut volvulus.Thanks to this series the investigators could highlight the more specifics signs of the volvulus included a new pattern.

Detailed description: Objective:

The small bowel volvulus is a rare cause of intestinal obstruction which may occur in utero and whose prenatal diagnosis is difficult. Sonographic signs are mainly indirect and nonspecific. The aim of this study is to present a retrospective analysis of prenatal sonographic findings in fetal segmental midgut volvulus. Thanks to this series the investigators could highlight the more specifics signs of the volvulus included a new pattern.

Methods:

Unicentric retrospective analysis of cases of prenatal midgut volvulus between 2006 and 2017. The primary inclusion criteria was postnatal diagnosis of prenatal volvulus based on post-natal findings and prenatal imaging findings. The exclusion criteria was the absence of prenatal imaging assessment. The investigators collected the clinical history and the echographic mode B and color Doppler. They have searched for some specific sign like " whirlpool sign " representing the winding of the mesenteric vein around the superior mesenteric arterywith color Doppler with arciform pattern of the midgut, hydro-meconium level in the dilated loops and position of mesenteric vessels for evaluation of the intestinal (mal) rotation. Gold standard was surgery or foetopathology if performed.

Eligibility criteria: Inclusion Criteria:

* postnatal diagnosis of prenatal volvulus based on post-natal findings and prenatal imaging findings

Exclusion Criteria:

* the absence of prenatal imaging assessment

Primary outcomes:
measure: echography
timeFrame: during the second (22-24 weeks) after ultrasound screening
measure: echography
timeFrame: the third (31-34 weeks) trimester after ultrasound screening
Secondary outcomes:
measure: ultrasound signs of complication
timeFrame: the third (31-34 weeks) after ultrasound screening
measure: ultrasound signs of complication
timeFrame: during the second (22-24 weeks) after ultrasound screening
measure: ultrasound signs of complication
timeFrame: 1 day
measure: ultrasound signs of complication
timeFrame: just after delivery
measure: presence or not of the volvulus
timeFrame: 1 day
measure: presence or not of the volvulus
timeFrame: during the second (22-24 weeks) after ultrasound screening
measure: presence or not of the volvulus
timeFrame: just after delivery
measure: presence or not of the volvulus
timeFrame: the third (31-34 weeks) after ultrasound screening
measure: presence or not ileal atresia.
timeFrame: during the second (22-24 weeks) after ultrasound screening
measure: presence or not ileal atresia.
timeFrame: the third (31-34 weeks) after ultrasound screening
measure: presence or not ileal atresia.
timeFrame: just after delivery
measure: presence or not ileal atresia.
timeFrame: 1 day
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
References: