Clinical trial NCT03246269: Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)
Official title: Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cognitive Impairment
Cognitive Decline
Cognition Disorders
Cognitive Symptom
Cognitive Change
Cognitive Deterioration
Cognitive Abnormality
Cognitive Impairment, Mild
Cognition Disorders in Old Age
Dementia
Dementia Alzheimers
Dementia, Alzheimer Type
Dementia, Mild
Dementia of Alzheimer Type
Lead sponsor: University Hospital, Basel, Switzerland
Sponsor class: OTHER
First posted: 2017-08-11
Enrollment: 334
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy volunteers

Brief summary: This observational cohort study in healthy volunteers establishes normative data for the German version of the Montreal Cognitive Assessment (MoCA) and investigates the possible impacts of demographics on the MoCA total score.

Detailed description: The Montreal Cognitive Assessment (MoCA) is a short tool to evaluate a multitude of cognitive domains (visuospatial / executive functioning, object naming, memory, attention, language, abstraction, orientation). The original English MoCA consistently showed very high sensitivity and specificity in distinguishing patients with mild cognitive impairment from healthy controls. Therefore it is an excellent tool for early recognition of cognitive disorders. Based on a Canadian sample, the MoCA proposes a cut-off-value of 26/30 points. However, there is increasing evidence of intercultural differences in terms of the best cut-off-score. In addition the original version only slightly corrects for possible influences of education - an adjustment for age- or gender-related effects is missing. Therefore, the aim of our study was to investigate the possible impacts of demographics on the MoCA total score and to provide normative values for a German-speaking population.

Eligibility criteria: Inclusion Criteria:

* Age ≥65 years
* Education ≥7 years
* Fluency in the German language
* Written informed consent

Exclusion Criteria:

* History of cognitive impairment
* Depression
* Severe sensory or motor impairment interfering with cognitive testing
* Serious somatic disease
* Disease or event affecting the central nervous system
* Cerebrovascular disease
* Regular medication with psychoactive drugs except for benzodiazepines
* Participation in a cognitive study within the last 3 months

Primary outcomes:
measure: Montreal Cognitive Assessment (MoCA) - German version
timeFrame: Baseline
Secondary outcomes:
measure: Mini-Mental State Examination (MMSE)
timeFrame: Baseline
measure: Geriatric Depression Scale (GDS)
timeFrame: Baseline
measure: Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB)
timeFrame: Baseline
Other outcomes:
Locations:
Study officials:
affiliation: Felix Platter Hospital Basel
name: Alessandra Thomann, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: University Hospital, Basel, Switzerland
name: Nicolai Goettel, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: University Hospital, Basel, Switzerland
name: Raphael Monsch, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Applied Sciences Koblenz
name: Manfred Berres, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Felix Platter Hospital Basel
name: Andreas Monsch, PhD
role: STUDY_CHAIR
References: