Clinical trial NCT03425708: Effect of Hyperuricaemia on Chronic Renal Disease
Official title: Study on the Effect of Hyperuricaemia on Chronic Renal Disease and Intervention
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Hyperuricemia
Chronic Renal Disease
Keywords: Uric Acid
Febuxostat
Chronic Renal Disease
Lead sponsor: The Affiliated Hospital of Xuzhou Medical University
Sponsor class: OTHER
Collaborators: name: The First People's Hospital of Xuzhou
First posted: 2018-02-07
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To investigate the Effect of Hyperuricaemia on Chronic Renal Disease and Intervention

Detailed description: This study aims to explore the best effective dose and adverse reaction of febuxostat in lowering serum uric acid to low level in patients with Chronic Renal Disease at different stages. To elucidate that low levels of serum uric acid can delay the progression of renal damage. Promote the application of anti uric acid drugs in the treatment of chronic renal failure and delay the progress of CKD in patients

Eligibility criteria: Inclusion Criteria:

* Non-dialysis CKD patients with serum uric acid greater than 7mg/dl.
* eGFR≥15ml/min/1.73m².
* Low salt, low protein, low purine diet.

Exclusion Criteria:

* Take drugs that raise blood uric acid at the same time.
* Patients with gout attacks.
* Patients with pregnant, lactating.
* Autosomal dominant polycystic kidney disease.
* Patients with poor general condition and multiple organ failure.

Primary outcomes:
measure: serum uric acid
timeFrame: up to 6 months
Secondary outcomes:
measure: serum creatinine
timeFrame: up to 6 months
Other outcomes:
Locations:
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical University
state: Jiangsu
Study officials:
affiliation: The Affiliated Hospital of Xuzhou Medical University
name: Dong Sun, MD
role: STUDY_DIRECTOR
References:
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