Clinical trial NCT01143714: A Study to Look at the Effects of Four Weeks of Treatment on the Healing of Diabetic Foot Ulcers
Official title: A Vehicle-Controlled Study to Determine the Effect of Four Weeks of Debridement With Collagenase Santyl Ointment (Santyl) on the Healing of Diabetic Foot Ulcers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Diabetic Foot Ulcers
Lead sponsor: Healthpoint
Sponsor class: INDUSTRY
First posted: 2010-06-14
Enrollment: 57
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the effect of four weeks of treatment with Santyl Ointment, compared to White Petrolatum, on the change from baseline in wound area of diabetic foot ulcers over four weeks, and on the proportion of subjects achieving complete wound closure within 12 weeks from initiation of treatment.


Eligibility criteria: Inclusion Criteria:

* The informed consent document Photography Release must be read, signed, and dated by the subject or the subject's legally authorized representative before conducting any study procedures or exams. In addition, the informed consent document must be signed and dated by the individual who consents the subject before conducting the screening visit. A photocopy of the signed informed consent document must be provided to the subject, and the original signed document placed in the subject's chart.
* Age 18 years and older. Subjects may be of either sex and of any race or skin type.
* Women of child-bearing potential (those who are not premenarchal, not surgically sterilized \[hysterectomy or bilateral oophorectomy\], or not post-menopausal) may participate in the study if they meet all of the following conditions:

  * they are not breast feeding
  * undertake an HCG serum pregnancy test, which must be negative
  * they do not intend to become pregnant during the study
  * they are using adequate birth control methods and they agree to continue using those methods for the duration of the study
* Post-menopausal is defined as no period in the previous 12 months Adequate birth control methods are defined as: hormonal-topical, oral, implantable or injectable contraceptives; mechanical-spermicide in conjunction with a barrier such as a condom or diaphragm; IUD; or, surgical sterilization of partner. For non-sexually active females, abstinence may be regarded as an adequate method of birth control; however, if the subject becomes sexually active during the study, she must agree to use an adequate birth control method as described above for the remainder of the study.

NOTE: Women who have had a bilateral tubal ligation are not considered to have been surgically sterilized and must agree to the conditions as specified above.

* Willing to make all required study visits and to use the Darco shoe off-loading device and insole.
* Able to follow instructions, particularly regarding the application of test articles and dressings at home. Able to apply the test article, or has a caregiver available to apply the test article according to the protocol.
* Have a diabetic foot ulcer, Wagner Grades† 1 or 2, on the plantar surface of the foot.
* Target ulcer present for at least 28 days, but no longer than 18 months, and has failed to close by ≥ 40% during the first 4 weeks of therapy administered during the past 4 to 8 weeks.
* Target ulcer area between 2 and 15 cm², post debridement, if required. 9- Adequate arterial blood flow as evidenced by an ankle brachial index (ABI) of \> 0.7 and ≤ 1.1; if the ABI is greater than 1.1, then a toe pressure of \> 30 mmHg OR a TcPO2 ≥ 40 mmHg; either secondary measure is acceptable, but if both are obtained, each must meet its respective cutoff.
* 10. Reasonable control of blood glucose, as evidenced by a serum HbA1C ≤ 12% at screening.
* 11.Acceptable state of health and nutrition as evidenced by a serum pre-albumin level ≥ 15 mg/dL (0.15 g/L) and serum albumin ≥ 2.0 g/dL (20 g/L) at screening.
* 12. Hematology values in the following ranges: WBC ≥ 3.0x109/L Hgb ≥ 10.0 g/dL Neutrophils ≥ 1.5x109/L Platelets ≥ 75 x109/L Normal blood smear
* Blood chemistry values and urinalysis in the following ranges (Healthpoint Ranges):

Total bilirubin ≤ 1.5 times the upper limit of normal (ULN) Alkaline phosphatase ≤ 2.5 times the ULN Alanine transaminase (ALT) ≤ 2.5 times the ULN Aspartate transaminase (AST) ≤ 2.5 times the ULN Serum creatinine ≤ 1.5 times the ULN Urinalysis: WBC \< 4/HPF; RBC \< 4/HPF

Exclusion Criteria:

* Contraindications or known hypersensitivity to the test articles or their components.
* Therapy with another investigational agent within 30 days, lower extremity angioplasty within 4 weeks, untreated osteomyelitis, or chemotherapy or radiation therapy within 5 years prior to screening.
* Prior therapy of the target wound with Santyl.
* Current therapy with systemic antibiotics to treat a foot ulcer, or prescription topical antibiotics on the target ulcer.
* Target ulcer located over the heel (talus, distal calcaneous, navicular, or cuboid).
* Fracture of bones in the target ulcer foot occurring within the past 3 months.
* Cellulitis or abscess of the target ulcer foot.
* A positive result from the screening Quantitative Bacteriology (Qbac) biopsy. A wound will be considered infected if the laboratory findings reveal ≥ 106 colony forming units (cfu) per gram of tissue or \> 1 beta-hemolytic Streptococcus per gram of tissue.
* Target ulcer tunneling, per probing.
* More than three DFU on the target foot. The target ulcer must be at least 2 cm from another ulcer.
* Concomitant severe burn, immunodeficiency disorder, hematologic disorder, or malignancy (other than non-melanoma skin cancer) beyond the in situ stage.
* Abnormal laboratory values that, in the opinion of the Principal Investigator, place the subject at risk for the study.
* Positive serum HCG pregnancy test.
* The Medical Monitor may declare any subject ineligible for a valid procedural or medical reason.

Primary outcomes:
measure: Change in Wound Area
timeFrame: 4 Weeks
Secondary outcomes:
measure: Number of Sharp Debridements Performed During the 4-week Treatment Phase and the 8-week Follow-up Period (12 Weeks Total)
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Sylmar
country: United States
facility: Olive View - UCLA Medical Center
state: California
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine
state: Illinois
city: Boston
country: United States
facility: Boston Medical Center
state: Massachusetts
city: Pittsburgh
country: United States
facility: The Foot and Ankle Institute of Western Pennsylvania
state: Pennsylvania
city: Wyomissing
country: United States
facility: Center for Advanced Wound Care
state: Pennsylvania
city: McAllen
country: United States
facility: Complete Family Foot Care
state: Texas
Study officials:
affiliation: Healthpoint
name: Herbert B Slade, MD
role: STUDY_CHAIR
References: