Clinical trial NCT02453204: STAND UP - Sedentary Behaviour in Older Adults: Investigating a New Therapeutic Paradigm
Official title: STAND UP - Sedentary Behaviour in Older Adults: Investigating a New Therapeutic Paradigm Work Package 3: Investigating the Effect of Sedentary Time, Reduced Sedentary Time and Increased Light-intensity Physical Activity on Metabolic and Psychological Health in Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Older Adults
Lead sponsor: University of Leicester
Sponsor class: OTHER
Collaborators: name: University of Glasgow
name: National Institute for Health Research, United Kingdom
name: National Health Service, United Kingdom
First posted: 2015-05-25
Enrollment: 76
Sex: ALL
Minimum age (years): 65
Maximum age (years): 79
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: Research has shown that reducing the time spent sitting can reduce the risk of many diseases, such as diabetes and heart disease, and improve health. It is estimated that many older adults typically spend 70% of their waking day sitting, but little is known about whether reducing sitting promotes health and well-being in this age group. The aim of this research is to investigate the health effects of reducing sitting time by replacing it with short periods of standing or walking in adults over the age of 65.


Eligibility criteria: Inclusion Criteria:

* Adults aged between 65 to 79 years inclusive
* Able to walk (without any assistive devices and not requiring assistance from another person)
* Ability to communicate in and understand English to participate in the informed consent process.

Exclusion Criteria:

* Regular purposeful exercise (≥75 minutes of self-reported vigorous exercise per week)
* Inability to stand or undertake light ambulation
* Psychological condition which limits participation in the study (e.g. dementia)
* Inability to communicate or understand English
* Steroid use
* Use of glucose lowering medication
* Inability to give informed consent

Primary outcomes:
measure: Insulin area under the curve
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
Secondary outcomes:
measure: Glucose area under the curve
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: Triglyceride area under the curve
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: 1H NMR Metabolomics spectroscopy
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: Blood pressure
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: Felt Arousal Scale (0-5)
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: Feeling Scale (-5 to +5)
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: Semantic Verbal Fluency Test (number of items)
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: Hopkins Verbal Learning Test (number of words recalled)
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: Trail Making Tests A (time to complete)
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: Trail Making Tests B (time to complete)
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: Rapid Visual Information Processing Test (number of sequences detected and errors)
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
measure: Karolinska Sleepiness Scale (1-9)
timeFrame: 3 experimental intervention study visits over an estimated period of 1 month
Other outcomes:
Locations:
city: Glasgow
country: United Kingdom
facility: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Avenue
city: Leicester
country: United Kingdom
facility: Leicester Diabetes Centre, Diabetes Research Unit, University of Leicester, Leicester General Hospital
Study officials:
affiliation: University of Leicester
name: Thomas Yates
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yates T, Edwardson CL, Celis-Morales C, Biddle SJH, Bodicoat D, Davies MJ, Esliger D, Henson J, Kazi A, Khunti K, Sattar N, Sinclair AJ, Rowlands A, Velayudhan L, Zaccardi F, Gill JMR. Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):139-146. doi: 10.1093/gerona/gly252.