louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02220764: Zirconia Based Fixed Dental Prostheses
Official title: Prospective Evaluation of Zirconia Based Tooth- and Implant- Supported Fixed Dental Prostheses
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Zirconia Based Fixed Dental Prostheses
Keywords: prospective study
chipping
survival rate
fracture resistance
zirconia
Lead sponsor: Technische Universität Dresden
Sponsor class: OTHER
First posted: 2014-08-20
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this prospective clinical study is to investigate the differences in the complication rates between tooth- and implant- supported zirconia based fixed dental prostheses (FDPs) with at least 4 units. The null-hypothesis is that there is no difference in the complication rates between implant- supported and tooth- supported zirconia FDPs.

Detailed description: The study aims to provide evidence regarding the clinical behaviour of long-span tooth- and implant-supported FDPs.

Eligibility criteria: Inclusion Criteria:

* Patients older than 18 years
* Missing of at least two adjacent teeth in the maxilla or mandibular
* Sufficient oral hygiene

Exclusion Criteria:

* Addiction to alcohol or drugs
* Severe craniomandibular disorders
* Severe systematic diseases
* Patients unable or unwilling to sign the informed consent form
* Untreated periodontitis

Primary outcomes:
measure: Number of Fixed Dental Prostheses (FDPs) With Failure
timeFrame: 3 years
Secondary outcomes:
measure: Number of Fixed Dental Prostheses (FDPs) With Chip/s
timeFrame: 3 years
Other outcomes:
measure: Number of of Fixed Dental Prostheses (FDPs) With Rough Surface
timeFrame: 3 years
Locations:
Study officials:
References:
citation: Konstantinidis IK, Jacoby S, Radel M, Boning K. Prospective evaluation of zirconia based tooth- and implant-supported fixed dental prostheses: 3-year results. J Dent. 2015 Jan;43(1):87-93. doi: 10.1016/j.jdent.2014.10.011. Epub 2014 Nov 5.
Clinical trial NCT02790164: Continuous NMB in PCAS
Official title: Continuous Neuromuscular Blocking Agent for out-of Hospital Cardiac Arrest; Multicenter Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Out-of-hospital Cardiac Arrest
Lead sponsor: Seoul St. Mary's Hospital
Sponsor class: OTHER
Collaborators: name: The Catholic University of Korea
name: Uijeongbu St. Mary's Hospital
name: Chonnam National University Hospital
name: Asan Medical Center
name: Hanil General Hospital
name: Ulsan Universty Hospital
name: Hanyang University Guri Hospitall
First posted: 2016-06-03
Enrollment: 81
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The main purpose of this study is to test the hypothesis that continuous NMB could improve outcome in cardiac arrest patients treated with therapeutic hypothermia.


Eligibility criteria: Inclusion Criteria:

1. Adult (older than 19)
2. OHCA with sustained ROSC
3. Comatose (i.e., not following commands) following ROSC
4. Undergoing targeted temperature management (TTM)
5. Time of enrollment ≤ 6hrs from ROSC

Exclusion Criteria:

1. Pre-existing dementia, brain injury, or dependence on others for ADLs (CPC \> 3)
2. Traumatic etiology for cardiac arrest
3. Protected population (pregnant, prisoner)

Primary outcomes:
measure: Lactate levels 24 hours after initiation of study drug
timeFrame: 24 hours
Secondary outcomes:
measure: Lactate change over time
timeFrame: 0, 12, 24, 36 hrs
measure: Survival
timeFrame: Duration of hospitalization, limit 180 days
measure: Good neurological outcome
timeFrame: Duration of hospitalization, limit 180 days
measure: Length of intensive care unit stay
timeFrame: Duration of ICU stay, limit 180 days
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul St. Mary's Hospital
Study officials:
affiliation: Seoul St. Mary's Hospital
name: Chun Song Youn, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04442464: Intraocular Pressure in Ocular Hypertensives With Scleral Lens Wear
Official title: Intraocular Pressure in Ocular Hypertensives With Scleral Lens Wear
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Ocular Hypertension
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2020-06-22
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of this study is to determine if short-term wear of a spherical rigid contact lens, called a scleral lens, will raise intraocular pressure in ocular hypertensive patients.

Detailed description: This is a randomized, self-controlled study designed to compare effectiveness of a scleral lens on intraocular pressure. In this study, all participants have one eye randomly selected to wear the scleral lenses during study measurements and the other eye serves as the control, non-lens wearing eye.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of ocular hypertension (IOP \>22 in each eye during at least two visits over the previous 3 years)
* May have had cataract extraction and intraocular lens (IOL)
* Not on topical medication for glaucoma
* No History of ALT/SLT
* Any Age, 18 years or older
* History of contact lens wear (except scleral lenses), as long as they are willing to not wear their lenses the day of the study

Exclusion Criteria:

* On topical medication for glaucoma
* Eye disease
* Inability to wear scleral lenses
* Any intraocular surgery other than uncomplicated cataract extraction.
* Known allergy to proparacaine eye drops

Primary outcomes:
measure: Intraocular Pressure (IOP)
timeFrame: 4 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Cherie Nau, OD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06339164: Breech Delivery Skills. Resident Learning Program
Official title: Breech Delivery Skills. Formal Lecture vs Digital Learning in Resident Learning Program.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Breech Presentation; Before Labor
Keywords: breech, learning, mannequin
Lead sponsor: G. d'Annunzio University
Sponsor class: OTHER
First posted: 2024-04-01
Enrollment: 20
Sex: ALL
Minimum age (years): 24
Maximum age (years): 38
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: all residents undergoing lecture for obstetric emergencies

Brief summary: Breech delivery is one of the mail topic in emergency obstetrics for Italian Board of Obstetrics and Gynecology. Formal frontal lecture and digital learning represent nowadays the two typical learning methods. A bedside evaluation it's not feasible due to rarity of such emergency, due to the common senior physicians involvement when it occurs, and due to medico-legal risks. Mannequin scenario represents the best way of skill evaluation

Detailed description: Residents will be recruited for "breech delivery" in two different ways. One group (20) will attend a formal frontal lecture on breech delivery of at least one hour. A second group matched for sex distribution, age, residency year (20) will receive a digital lecture. After one month the two groups will test their abilities on a low fidelity mannequin. The simulation session will be recorded and evaluated by 5 specialists in a blind way. During the simulation the main topics of breech extraction are recorded. All residents will receive a questionnaire identifying the subject, previous experience bedside or in a course, and the agreement for video recording and data analysis. After the simulation test they will receive a second questionnaire indicating improvement levels (using a Kirkpatrick model and a 5-point Likert scale).

Eligibility criteria: Inclusion Criteria: residents in University of Chieti Medical school -

Exclusion Criteria: none

-

Primary outcomes:
measure: Skills capacities
timeFrame: 1 months
measure: Skills capacities
timeFrame: 1 month
Secondary outcomes:
measure: learning qualities
timeFrame: 1 month
Other outcomes:
Locations:
city: Pescara
country: Italy
facility: Claudio Celentano
state: PE
Study officials:
References:
Clinical trial NCT04992364: Clinical Impacts of Burnout Syndrome Among Anesthesiology Residents
Official title: Relationship Between Burnout Score and Clinical Performance on Anesthesiology and Intensive Therapy Residents
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Burnout, Caregiver
Keywords: anesthesiology
burnout
clinical performances
residency
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2021-08-05
Enrollment: 55
Sex: ALL
Minimum age (years): 25
Maximum age (years): 35
Standard ages: ADULT
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Anesthesiology residents who were on second until fourth year of residency

Brief summary: This study aimed to determine the relationship between burnout levels and clinical performances of anesthesiology residents.

Detailed description: Fifty-five second until fourth year anesthesiology residents, who were not on any mental medication treatment, were recruited consecutively and asked to fill out questionnaires which are; the Maslach Burnout Inventory (MBI) questionnaire to assess burnout levels, Best Practice Anesthesiologist questionnaire to assess positive clinical performance, Anesthesiology Residents' Self-Reported Errors and Quality of Care questionnaire to assess negative clinical performance.

Eligibility criteria: Inclusion Criteria:

* second until fourth year anesthesiology residents
* not on any mental medication treatment
* willing to participate

Exclusion Criteria:

* on paid leave
* rejected to become the sample
* had their shift in 24 hours prior to this study

Primary outcomes:
measure: Positive clinical performance
timeFrame: 1 month through study completion
Secondary outcomes:
measure: Negative clinical performance
timeFrame: 1 month through study completion
Other outcomes:
Locations:
city: Jakarta
country: Indonesia
facility: Cipto Mangunkusumo Cental National Hospital
state: DKI Jakarta
Study officials:
References:
Clinical trial NCT04383964: Transport Distraction Osteogenesis for Ramus-Condyle Unit
Official title: Transport Distraction Osteogenesis for Reconstruction of Ramus-Condyle Unit Following Release of Temporomandibular Joint Ankylosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bilateral or Unilateral Deficient Ramus-condyle Unit
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2020-05-12
Enrollment: 10
Sex: ALL
Minimum age (years): 1
Maximum age (years): 50
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: this study was done to evaluate the use of transport distraction osteogenesis in restoring the deficient condyle/ramus unit of patients with unilateral or bilateral TMJ ankylosis to correct the resultant deformity

Detailed description: 10 patients with post ankylosis deficient ramus /condyle unit who underwent release procedure in the Maxillofacial and Plastic Surgery Department, Faculty of Dentistry, Alexandria University, Egypt.

all patients were assessed clinically and by imaging using OPG, lateral and PA cephalometry, and cone beam CT to assess the deficient ramus/condyle unit (RCU) then patients were operated using transport distraction osteogenesis to lengthen the RCU. Then follow up of all patients both clinically and radiographically was adopted.

Eligibility criteria: Inclusion Criteria:

* Post ankylosis deformity: Bilateral or unilateral deficient ramus-condyle unit (RCU) after TMJ release

Exclusion Criteria:

* Mentally affected patients.
* Medically compromised patients.
* Post menopausal osteoporosis.

Primary outcomes:
measure: Jaw movements (changes in jaw movements through 18 months follow up)
timeFrame: at 3rd, 6th and 18th months
measure: Ramus height (changes of ramus heights through 18 months follow up)
timeFrame: at 3rd and 6th months
Secondary outcomes:
measure: Occlusal discrepancy or anterior open bite
timeFrame: 18th months
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Faculty of Dentistry
state: Azarita
Study officials:
References:
Clinical trial NCT02358564: Gut Permeability, Sensitivity and Symptomatology
Official title: Gut Permeability, Sensitivity and Symptomatology: Is There a Link and Explanation for Exacerbation of Symptoms Post Meals
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Irritable Bowel Syndrome
Visceral Hypersensitivity
Keywords: IBS
Irritable Bowel Syndrome
Visceral Hypersensitivity
Permeability
Small Bowel
Lactulose
Mannitol
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
Collaborators: name: University of Erlangen-Nürnberg
name: Heidelberg University
name: University of Leeds
First posted: 2015-02-09
Enrollment: 39
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: To better understand the relationship between gut barrier function and the symptomatology and pathophysiology of irritable bowel syndrome (IBS).


Eligibility criteria: Inclusion criteria

* Age 18 to 70 years
* No abdominal surgery (except appendectomy, cholecystectomy, hernia repair, hysterectomy, and C-section).
* Written informed consent

Exclusion criteria

* Females who are pregnant or breastfeeding
* Use of tobacco products within the past 6 months (since nicotine may affect intestinal permeability)
* Use of NSAIDs or aspirin within the past week (since NSAIDs affect intestinal permeability)
* Use of oral corticosteroids within the previous 6 weeks
* Ingestion of artificial sweeteners such as Splenda (sucralose), Nutrasweet (aspartame), lactulose or mannitol 2 days before the study tests begins, e.g. foods to be avoided are sugarless gyms or mints and diet soda.
* Ingestion of any prescription, over the counter, or herbal medications which can affect gastrointestinal transit 7 days before the study begins.
* Proton pump inhibitors.
* Antibiotics for the preceding 60 days before the start of the study.
* (vii) Alcohol intake beyond the recommended safe limit (\<21 unites per week)
* Bleeding disorders or medications that increase risk of bleeding from mucosal biopsies.
* Known allergy to fluorescein
* Inflammatory bowel diseases, celiac disease.

Primary outcomes:
measure: Mean Percent of complete epithelial cell loss
timeFrame: 72 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Jacksonville
country: United States
facility: Mayo Clinic in Florida
state: Florida
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Madhusudan Grover, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT07000864: A Study of Live Tumor Fragments of Surgical Resections
Official title: Predicting Response to Therapy From Analysis of Live Tumor Fragments of Surgical Resections
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Cancer
Tumor
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2025-06-03
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male and female patients planning to undergo surgery for removal of cancer at Mayo Clinic in Florida.

Brief summary: The purpose of this study is to obtain unused resected tumor tissue sample and associated clinical data from patients enrolled in this study to research ex vivo treatment response and integrity of tumor microenvironment using omics analysis and imaging while maintaining cell stability in a live environment.


Eligibility criteria: Inclusion Criteria:

* Ability to understand and sign informed consent
* Planning to undergo a surgical procedure to remove cancer

Exclusion Criteria:

* Does not meet Inclusion criteria
* No tissue for research available at time of surgery

Primary outcomes:
measure: Tissue response to treatment
timeFrame: Up to 72 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Jacksonville
country: United States
facility: Mayo Clinic in Florida
state: Florida
Study officials:
affiliation: Mayo Clinic
name: Debabrata Mukhopadhyay, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00846690: Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel
Official title: Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel for Control of Pain of Dental Needle Insertion in the Palate
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Dental Pain
Postoperative Pain
Keywords: topical anesthetics
topical anesthesia
20% benzocaine
TAC alternate gel
combination topical anesthetics
dental anesthesia
Lead sponsor: The University of Texas Health Science Center, Houston
Sponsor class: OTHER
First posted: 2009-02-19
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The project is a study comparing the effectiveness of two topical anesthetics for control of pain associated with dental needle insertion in the palatal mucosa. A standard dental topical anesthetic (20% benzocaine) will serve as an "active" control and will be compared to a combination topical anesthetic, consisting of 20% lidocaine, 4% tetracaine and 2% phenylephrine (TAC Alternate Gel, Compounding Arts Pharmacy, Lafayette, LA).


Eligibility criteria: Inclusion Criteria:

1. Volunteers 18 years or older
2. Ability to consent to participate in the research
3. Ability to communicate a VAS score
4. Generally healthy, ASA I and ASA II
5. No known drug allergies
6. Ability to tolerate pulse oximeter and blood pressure cuff without psychological, or physiological consequence

Exclusion Criteria:

1. Allergy or other contraindications to the topical anesthetics
2. Inability to consent to participation in the study
3. Use of analgesics prior to the procedure
4. Vulnerable populations

Primary outcomes:
measure: visual analogue scale score
timeFrame: pre-op, insertion, every minute post-op for 10 minutes
Secondary outcomes:
measure: blood pressure
timeFrame: three times pre-op, insertion, ten times post-op
measure: oxygen saturation
timeFrame: three times pre-op, insertion, ten times post-op
measure: heart rate
timeFrame: three times pre-op, insertion, ten times post-op
Other outcomes:
Locations:
city: 6655 Travis Suite 460
country: United States
facility: UT Pediatric Dentistry Clinic Houston Medical Center
state: Texas
Study officials:
affiliation: UT Health Science Center Houston
name: Femme L Ambrosio, DDS
role: PRINCIPAL_INVESTIGATOR
affiliation: UT Health Science Center Houston
name: Arthur H Jeske, DDS, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT05860790: Prospective Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery
Official title: Prospective Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Venous Thromboembolism
Neurosurgery
Risk Assessment
Lead sponsor: Capital Medical University
Sponsor class: OTHER
First posted: 2023-05-16
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Surgical patients who have undergone neurosurgery

Brief summary: Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery: A Multicenter, Prospective, and Cohort Study

Detailed description: A clinical prediction model for VTE after neurosurgical procedures during hospitalization has been developed and internally retrospectively validated. A multicenter, prospective cohort study is planned to validate this clinical prediction model again.

Eligibility criteria: Inclusion Criteria:

1. age \>18 years
2. underwent neurosurgical procedures during hospitalization
3. underwent preoperative ultrasound examination

Exclusion Criteria:

1. a patient with obvious bacterial or viral infection within the past two weeks before admission
2. a patient with venous thromboembolism within the past three months before surgery
3. a patient with anticoagulant therapy (direct oral anticoagulants, low molecular weight heparin) was administered continuously or intermittently before admission
4. a patient with a prior coagulation dysfunction

Primary outcomes:
measure: Symptomatic or asymptomatic VTE
timeFrame: 2023.3-2023.7
Secondary outcomes:
measure: DVT
timeFrame: 2023.3-2023.7
measure: PE
timeFrame: 2023.3-2023.7
measure: Proximal DVT
timeFrame: 2023.3-2023.7
Other outcomes:
Locations:
city: Beijing
country: China
facility: Sanbo Brain Hospital, Capital Medical University
Study officials:
affiliation: Capital Medical University
name: Hongwei Zhang, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01660490: Development and Validation of Intraoperative Image-quality Criteria
Official title: Development and Validation of Intraoperative Image-quality Criteria A Retrospective Multicenter Case Series to Validate a Set of Intraoperative Image-quality Criteria
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Proximal Femur Fractures
Keywords: Radiographic Image Enhancement,
Intraoperative Care
Femoral Fractures
Femoral Neck Fractures
Hip Fractures, Internal Fixators
Fracture Fixation Internal
Fracture Fixation Intramedullary
Fractures Bone
Lead sponsor: AO Innovation Translation Center
Sponsor class: OTHER
First posted: 2012-08-08
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients with a proximal femur fractures treated with ORIF between May 2010 and December 2010

Brief summary: An expert panel of surgeons agreed that there is not any established, standardized approach to the teaching of intraoperative imaging and that there may be practice gaps in decision making and the use of imaging among trauma surgeons.

The panel is set to initiate a consensus-based evaluation process to develop a list of criteria for assessing images and would like to validate these criteria for differentiating good quality versus poor quality images in term of reliability and accuracy.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of proximal femur fracture
* Operated between May 2010 and December 2010
* Open Reduction Internal Fixation (ORIF)
* Lateral and anteroposterior intraoperative images available

Exclusion Criteria:

None

Primary outcomes:
measure: Evaluate if C-Arm pictures can be a predictive factor for the outcome of repositioning of humerus fractures.
timeFrame: Intraoperatively
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Hospital of the University of Pennsylvania
state: Pennsylvania
city: Innsbruck
country: Austria
facility: Prof. Michael Blauth
state: Tyrol
city: Basel
country: Switzerland
facility: Universitätsspital Basel
Study officials:
affiliation: Medical University Innsbruck
name: Michael Blauth, Professor
role: PRINCIPAL_INVESTIGATOR
References: