Clinical trial NCT03259321: Fish, Polyunsaturated Fatty Acids Intake and Type 2 Diabetes
Official title: Fish, Polyunsaturated Fatty Acids Intake and Type 2 Diabetes in CHNS
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Type2 Diabetes
Keywords: Fish
Polyunsaturated fatty acids
CHNS
Lead sponsor: Zhejiang University
Sponsor class: OTHER
Collaborators: name: National Institute of Health and Nutrition
First posted: 2017-08-23
Enrollment: 15100
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: CHNS is an ongoing, large-scale, household-based cohort starting in 1989. The survey used a multi-stage, random cluster process to draw a sample of 9 provinces and municipal cities, which take up about half of Chinese population.

Brief summary: The role of fishery diet and polyunsaturated fatty acids (PUFA) in the development of type 2 diabetes (T2D) is heavily debated but evidence from large populations in China is scant. The investigators aim to use data from the China Health and Nutrition Survey (CHNS) to assess the long-term association between fish, PUFA intake and T2D risk.

Detailed description: The role of fishery diet and polyunsaturated fatty acids (PUFA) in the development of T2D is heavily debated but evidence from large populations in China is still lacking. The investigators aim to utilize data from China Health and Nutrition Survey (CHNS, 1997-2011). The investigators will calculate cumulative means of fish and PUFA intake based on 3-day food records in each wave. Sex-specific Cox regression models will be used to estimate relative risk of T2D. Results from this work will provide epidemiological evidence for improving recommendations on fish and PUFA intake for Chinese in dietary guidelines.

Eligibility criteria: Inclusion Criteria:

* Adults aged ≥20 with complete data on diet and follow-up time

Exclusion Criteria:

* Missing information for Type 2 diabetes
* Type 2 diabetes
* Cardiovascular disease

Primary outcomes:
measure: Type 2 diabetes
timeFrame: From entry into the study (baseline: 1997-2009) until 2011
Secondary outcomes:
measure: Fish and polyunsaturated fatty acids intake
timeFrame: From entry into the study (baseline: 1997-2009) until 2011
Other outcomes:
Locations:
Study officials:
References:
citation: Zhuang P, Mao L, Wu F, Wang J, Jiao J, Zhang Y. Cooking Oil Consumption Is Positively Associated with Risk of Type 2 Diabetes in a Chinese Nationwide Cohort Study. J Nutr. 2020 Jul 1;150(7):1799-1807. doi: 10.1093/jn/nxaa103.
citation: Wu F, Mao L, Zhuang P, Chen X, Jiao J, Zhang Y. Plant-sourced cooking oil consumption is associated with lower total mortality in a longitudinal nationwide cohort study. Clin Nutr. 2020 Dec;39(12):3703-3710. doi: 10.1016/j.clnu.2020.03.031. Epub 2020 Apr 2.
citation: Zhuang P, Shou Q, Wang W, He L, Wang J, Chen J, Zhang Y, Jiao J. Essential Fatty Acids Linoleic Acid and alpha-Linolenic Acid Sex-Dependently Regulate Glucose Homeostasis in Obesity. Mol Nutr Food Res. 2018 Sep;62(17):e1800448. doi: 10.1002/mnfr.201800448. Epub 2018 Aug 12.