Clinical trial NCT06419569: Efficacy of High Power Laser Versus Low Level Laser in Ultrasonographic and Functional Outcomes in Patients With Knee Osteoarthritis
Official title: Efficacy of High Power Laser Versus Low Level Laser in Ultrasonographic and Functional Outcomes in Patients With Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Knee Osteoarthritis
Keywords: High Power Laser
Low Level Laser
Ultrasonographic changes
Knee Osteoarthritis
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-05-17
Enrollment: 90
Sex: ALL
Minimum age (years): 45
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: high power laser and low level laser
Primary purpose: TREATMENT

Brief summary: this study will be conducted to compare between high power laser and low-intensity laser on ultrasonographic and functional outcomes in patients with knee osteoarthritis

Detailed description: Osteoarthritis (OA) is a major source of pain, disability, and socioeconomic cost worldwide. The epidemiology of the disorder is complex and multifactorial, with genetic, biological, and biomechanical components. It is estimated that 63 to 85 percent of Americans over age 65 have radiographic signs of OA and that 35 to 50 percent have symptoms of pain, stiffness or limitation of motion. Between 9 and 12 percent of elderly Americans (approximately 3 million people) have enough impairment from OA that they cannot perform their major activities, and half of these individuals are totally disabled (confined to bed or a wheelchair). High power laser therapy (HPL) that involves higher-intensity laser radiation is a new, painless, and powerful modality that showed significant results in pain reduction. One of the modalities commonly used by clinicians was Low Level Laser Therapy introduced as an alternative, safe and non-invasive treatment for OA about 30 years ago.A more recent systemic review investigated the effects of low-level and high-intensity laser therapy as adjunctive to rehabilitation exercise on pain, stiffness and function in knee osteoarthritis and concluded that Both LLLT and HPL are beneficial as adjuncts to rehabilitation exercise in the management of knee OA. Based on an indirect comparison, the HPL and exercise seems to have higher efficacy in reducing knee pain and stiffness, and in increasing function. To confirm this finding, a direct comparative investigation of the two types of laser therapy may be necessary. ninety patients with knee osteoarthritis will be assigned randomly to three groups; the first experimental will receive high power laser plus conventional physical therapy, second one will receive low-intensity laser and traditional physical therapy, finally, the third group will receive traditionally therapy only

Eligibility criteria: Inclusion Criteria:

* X-ray stages II and III osteoarthritis
* Age between 45 and 75 years.
* BMI equal to or less than 35.

Exclusion Criteria:

* Unwillingness to participate in the study.
* Uncompleted evaluation/treatment programs.
* Any damage to the knee joint during the study.
* Using any treatment other than prescribed therapeutic protocols.

Primary outcomes:
measure: osteophyte diameter
timeFrame: up to eight weeks
measure: hyaline cartilage thickness assessment
timeFrame: up to eight weeks
Secondary outcomes:
measure: knee function
timeFrame: up to eight weeks
measure: pain intensity
timeFrame: up to eight weeks
measure: knee range of motion
timeFrame: up to eight weeks
measure: pressure pain threshold
timeFrame: up to eight weeks
Other outcomes:
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