Clinical trial NCT04885790: Investigation of Dynamic Hyperinflation and Its Relationship With Functional Exercise Capacity in Children With Bronchiectasis
Official title: Investigation of Dynamic Hyperinflation and Its Relationship With Functional Exercise Capacity in Children With Bronchiectasis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bronchiectasis
Keywords: bronchiectasis
children
dynamic hyperinflation
exercise capacity
pulmonary function
Lead sponsor: Izmir Bakircay University
Sponsor class: OTHER
Collaborators: name: Ege University
First posted: 2021-05-13
Enrollment: 40
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Children with bronchiectasis

Brief summary: Prevalence of dynamic hyperinflation and its relationship with functional exercise capacity will be evaluated in children with bronchiectasis.

Detailed description: Exercise or hyperpnea-induced air trapping is referred to as dynamic hyperinflation. In the presence of high resistance to expiratory flows and short expiratory times, the respiratory system is unable to return to its resting volume at the end of exhalation. The positive pressure within regions of hyperinflated lung raises the mean intrathoracic pressure and causes the inspiratory muscles to operate at a higher than resting lung volume. Thus, dynamic hyperinflation places the respiratory muscles at a considerable mechanical disadvantage and further impairs respiratory function. Dynamic hyperinflation is considered to be a key determinant of exercise capacity in patients with obstructive lung diseases. Although bronchiectasis is one of the obstructive lung diseases, the presence of dynamic hyperinflation in these patients has not been adequately investigated. Management guidelines of bronchiectasis state that imaging methods or pulmonary function tests alone is not sufficient to determine the disease burden and prognosis in these patients, so they recommend including detailed evaluation of exercise tolerance in the management of bronchiectasis. Aim of this study is to investigate the prevalence of dynamic hyperinflation and its relationship with functional exercise capacity in children with bronchiectasis.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of bronchiectasis

Exclusion Criteria:

* Hospitalization history during past month
* Diagnosis of any other chronic childhood diseases such as cerebral palsy or neuromuscular diseases which may impede exercise tolerance

Primary outcomes:
measure: Dynamic hyperinflation
timeFrame: At baseline
Secondary outcomes:
measure: Six-minute walk distance
timeFrame: At baseline
measure: Minute ventilation
timeFrame: At baseline
measure: Breathing reserve
timeFrame: At baseline
measure: Forced Vital Capacity (FVC)
timeFrame: At baseline
measure: Forced Expiratory Volume in 1 second (FEV1)
timeFrame: At baseline
measure: Peak Expiratory Flow (PEF)
timeFrame: At baseline
measure: Handgrip strength
timeFrame: At baseline
measure: M. Quadriceps strength
timeFrame: At baseline
measure: Leicester Cough Questionnaire
timeFrame: At baseline
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: Ege University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Pulmonology
Study officials:
References: